DDR1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A6NHL2 Y319 Sugiyama TUBAL3 TTACFESSNQLVKCDPRLGKyMACCLLyRGDVVPKEVNAAI
O00469 Y444 Sugiyama PLOD2 LWSNFWGALSPDGYYARsEDyVDIVQGNRVGVWNVPYMANV
O43390 Y376 Sugiyama HNRNPR HNRPR ILEKSFSEFGKLERVKKLKDyAFVHFEDRGAAVKAMDEMNG
O60506 Y373 Sugiyama SYNCRIP HNRPQ NSAP1 ILEKAFsQFGKLERVKKLKDyAFIHFDERDGAVKAMEEMNG
O60814 Y38 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
O75369 Y1576 Sugiyama FLNB FLN1L FLN3 TABP TAP ITDQEGKPKRAIVHDNKDGtyAVtyIPDKtGRYMIGVTYGG
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06493 T161 EPSD CDK1 CDC2 CDC28A CDKN1 P34CDC2 tIKLADFGLARAFGIPIRVytHEVVTLWYRSPEVLLGsARY
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900 Y313 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P07900 Y492 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLR
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238 Y484 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P08865 Y156 Sugiyama RPSA LAMBR LAMR1 EAsyVNLPtIALCNTDSPLRyVDIAIPCNNKGAHSVGLMWW
P09234 Y8 Sugiyama SNRPC _____________MPKFyCDyCDtyLtHDsPsVRKTHCSGR
P10809 Y243 Sugiyama HSPD1 HSP60 yIsPyFINtsKGQKCEFQDAyVLLsEKKIssIQsIVPALEI
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P13639 Y730 Sugiyama EEF2 EF2 HADAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQ
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P18669 Y142 Sugiyama PGAM1 PGAMA CDABP0006 PPPPMEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIAR
P24941 T160 EPSD CDK2 CDKN2 AIKLADFGLARAFGVPVRtytHEVVtLWyRAPEILLGCKYY
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P30101 Y100 Sugiyama PDIA3 ERP57 ERP60 GRP58 LAKVDCTANTNTCNKyGVsGyPtLKIFRDGEEAGAyDGPRt
P31939 Y362 Sugiyama ATIC PURH OK/SW-cl.86 IAPGyEEEALTILSKKKNGNyCVLQMDQsYKPDENEVRTLF
P32119 Y115 Sugiyama PRDX2 NKEFB TDPX1 GLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFIIDGK
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P43121 Y222 Sugiyama MCAM MUC18 YTLQSILKAQLVKEDKDAQFyCELNYRLPSGNHMKEsREVT
P47756 Y59 Sugiyama CAPZB LLSSVDQPLKIARDKVVGKDyLLCDyNRDGDSyRsPWSNKy
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P52788 Y336 Sugiyama SMS GNCVNLTEALSLYEEQLGRLyCPVEFSKEIVCVPSYLELWV
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P57053 Y38 Sugiyama H2BC12L H2BFS H2BS1 AVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssK
P58876 Y38 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
P60660 Y89 Sugiyama MYL6 HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62750 Y144 Sugiyama RPL23A VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P62750 Y74 Sugiyama RPL23A LRRQPKYPRKSAPRRNKLDHyAIIKFPLTTEsAMKKIEDNN
P62807 Y38 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI AVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssK
P62826 Y146 Sugiyama RAN ARA24 OK/SW-cl.81 IKDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLAR
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P68363 Y312 Sugiyama TUBA1B tNACFEPANQMVKCDPRHGKyMACCLLyRGDVVPKDVNAAI
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P68366 Y312 Sugiyama TUBA4A TUBA1 tNACFEPANQMVKCDPRHGKyMACCLLyRGDVVPKDVNAAI
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q08345 Y513 SIGNOR|EPSD DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE PPHSAPCVPNGSALLLSNPAyRLLLATyARPPRGPGPPTPA
Q08345 Y569 PSP DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE EPEKPGAPLLPPPPQNSVPHyAEADIVTLQGVTGGNTyAVP
Q08345 Y586 PSP DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE VPHyAEADIVTLQGVTGGNTyAVPALPPGAVGDGPPRVDFP
Q08345 Y797 Sugiyama DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE NFTIKIADFGMsRNLyAGDyyRVQGRAVLPIRWMAWECILM
Q12931 Y498 Sugiyama TRAP1 HSP75 HSPC5 GQLtsLsEyASRMRAGtRNIyyLCAPNRHLAEHsPyyEAMK
Q14257 Y311 Sugiyama RCN2 ERC55 NPDLFLtsEAtDyGRQLHDDyFyHDEL______________
Q15375 Y608 Sugiyama EPHA7 EHK3 HEK11 ADQEGDEELyFHFKFPGTKTyIDPEtyEDPNRAVHQFAKEL
Q15375 Y614 Sugiyama EPHA7 EHK3 HEK11 EELyFHFKFPGTKTyIDPEtyEDPNRAVHQFAKELDASCIK
Q58FF8 Y260 Sugiyama HSP90AB2P HSP90BB VRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVW
Q58FG0 Y177 Sugiyama HSP90AA5P HSP90AE GQLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQ
Q5QNW6 Y38 Sugiyama H2BC18 HIST2H2BF AVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q71U36 Y312 Sugiyama TUBA1A TUBA3 tNACFEPANQMVKCDPRHGKyMACCLLyRGDVVPKDVNAAI
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q86W56 Y832 Sugiyama PARG DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q93079 Y38 Sugiyama H2BC9 H2BFJ HIST1H2BH AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q99877 Y38 Sugiyama H2BC15 H2BFD HIST1H2BN AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99879 Y38 Sugiyama H2BC14 H2BFE HIST1H2BM AINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99880 Y38 Sugiyama H2BC13 H2BFC HIST1H2BL AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q9BQE3 Y312 Sugiyama TUBA1C TUBA6 TNACFEPANQMVKCDPRHGKyMACCLLyRGDVVPKDVNAAI
Q9BQE3 Y432 Sugiyama TUBA1C TUBA6 GMEEGEFSEAREDMAALEKDyEEVGADsADGEDEGEEy___
Q9BZX2 Y203 Sugiyama UCK2 UMPK SQYITFVKPAFEEFCLPTKKyADVIIPRGADNLVAINLIVQ
Q9HA47 Y205 Sugiyama UCK1 URK1 TQYTTFVKPAFEEFCLPTKKyADVIIPRGVDNMVAINLIVQ
Q9UBR2 Y76 Sugiyama CTSZ YLSPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHA
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Recycling pathway of L1 R-HSA-437239 7.721612e-11 10.112 0 0
Gap junction trafficking and regulation R-HSA-157858 1.971744e-09 8.705 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.014800e-08 7.994 0 0
Gap junction trafficking R-HSA-190828 1.443387e-08 7.841 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.371762e-08 7.863 0 0
Axon guidance R-HSA-422475 1.308206e-08 7.883 0 0
Nervous system development R-HSA-9675108 1.056222e-08 7.976 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.718262e-08 7.765 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.411514e-08 7.618 0 0
L1CAM interactions R-HSA-373760 5.540308e-08 7.256 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.229637e-08 7.085 0 0
Aggrephagy R-HSA-9646399 1.055546e-07 6.977 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.444478e-07 6.840 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.900861e-07 6.721 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.230541e-07 6.652 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.461884e-07 6.461 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.730352e-07 6.325 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.845739e-07 6.233 0 0
Gap junction assembly R-HSA-190861 6.583682e-07 6.182 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.427739e-07 6.074 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.398089e-07 6.027 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.079360e-06 5.967 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.342471e-06 5.872 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.413855e-06 5.850 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.568167e-06 5.805 0 0
MAPK family signaling cascades R-HSA-5683057 1.700678e-06 5.769 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.038036e-06 5.691 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.560041e-06 5.449 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 4.491168e-06 5.348 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 4.414534e-06 5.355 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.143780e-06 5.383 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.238867e-06 5.281 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.590827e-06 5.253 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.718347e-06 5.243 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.229269e-06 5.206 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.065412e-05 4.972 0 0
Viral Infection Pathways R-HSA-9824446 9.996690e-06 5.000 0 0
PKR-mediated signaling R-HSA-9833482 1.065412e-05 4.972 0 0
FLT3 signaling in disease R-HSA-9682385 1.313936e-05 4.881 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.457654e-05 4.836 0 0
Kinesins R-HSA-983189 1.747974e-05 4.757 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.917347e-05 4.717 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.975810e-05 4.704 0 0
Post NMDA receptor activation events R-HSA-438064 1.975810e-05 4.704 0 0
Selective autophagy R-HSA-9663891 2.125645e-05 4.673 0 0
IGF1R signaling cascade R-HSA-2428924 2.508656e-05 4.601 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.736278e-05 4.563 0 0
MET activates PTPN11 R-HSA-8865999 3.075954e-05 4.512 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 3.057608e-05 4.515 0 0
Protein folding R-HSA-391251 3.025745e-05 4.519 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.400453e-05 4.468 0 0
MHC class II antigen presentation R-HSA-2132295 3.805780e-05 4.420 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.224986e-05 4.374 0 0
COPI-mediated anterograde transport R-HSA-6807878 4.224986e-05 4.374 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.487666e-05 4.348 0 0
Hedgehog 'off' state R-HSA-5610787 5.449108e-05 4.264 0 0
Intraflagellar transport R-HSA-5620924 5.661350e-05 4.247 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.164031e-05 4.210 0 0
Separation of Sister Chromatids R-HSA-2467813 6.261664e-05 4.203 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.306865e-05 4.200 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.841922e-05 4.165 0 0
PI3K Cascade R-HSA-109704 6.855941e-05 4.164 0 0
Signal Transduction R-HSA-162582 1.002077e-04 3.999 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.179660e-04 3.928 0 0
Macroautophagy R-HSA-1632852 1.116655e-04 3.952 0 0
Adaptive Immune System R-HSA-1280218 1.187794e-04 3.925 0 0
IRS-mediated signalling R-HSA-112399 1.270508e-04 3.896 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.284101e-04 3.891 0 0
Developmental Biology R-HSA-1266738 1.399791e-04 3.854 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.539601e-04 3.813 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.586141e-04 3.800 0 0
STAT5 Activation R-HSA-9645135 1.733664e-04 3.761 0 0
Insulin receptor signalling cascade R-HSA-74751 2.195464e-04 3.658 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.088683e-04 3.680 0 0
Autophagy R-HSA-9612973 2.272530e-04 3.643 0 0
Interleukin-2 family signaling R-HSA-451927 2.462275e-04 3.609 0 0
Immune System R-HSA-168256 2.556228e-04 3.592 0 0
Interferon Signaling R-HSA-913531 3.024267e-04 3.519 0 0
Infectious disease R-HSA-5663205 3.266806e-04 3.486 0 0
Membrane Trafficking R-HSA-199991 3.272247e-04 3.485 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.322958e-04 3.364 0 0
Mitotic Anaphase R-HSA-68882 4.929975e-04 3.307 0 0
Signaling by Leptin R-HSA-2586552 5.049712e-04 3.297 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.092308e-04 3.293 0 0
Signaling by Hedgehog R-HSA-5358351 5.125048e-04 3.290 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.760191e-04 3.240 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.210158e-04 3.142 0 0
G2/M Transition R-HSA-69275 7.328349e-04 3.135 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.842027e-04 3.106 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.024158e-04 3.096 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.024158e-04 3.096 0 0
Potential therapeutics for SARS R-HSA-9679191 8.600543e-04 3.065 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 9.177342e-04 3.037 0 0
Mitotic Prometaphase R-HSA-68877 9.255696e-04 3.034 0 0
Downstream signal transduction R-HSA-186763 9.843164e-04 3.007 0 0
HCMV Early Events R-HSA-9609690 1.019886e-03 2.991 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 1.040759e-03 2.983 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.193418e-03 2.923 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.157623e-03 2.936 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.231928e-03 2.909 0 0
Signaling by Insulin receptor R-HSA-74752 1.334795e-03 2.875 0 0
HCMV Infection R-HSA-9609646 1.353801e-03 2.868 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.431797e-03 2.844 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.498154e-03 2.824 0 0
Vesicle-mediated transport R-HSA-5653656 1.688372e-03 2.773 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.109041e-03 2.676 0 0
PI Metabolism R-HSA-1483255 2.223822e-03 2.653 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.306272e-03 2.637 0 0
FLT3 Signaling R-HSA-9607240 2.526376e-03 2.598 0 0
Tie2 Signaling R-HSA-210993 2.568969e-03 2.590 0 0
GAB1 signalosome R-HSA-180292 2.568969e-03 2.590 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.589998e-03 2.587 0 0
Parasite infection R-HSA-9664407 2.589998e-03 2.587 0 0
Leishmania phagocytosis R-HSA-9664417 2.589998e-03 2.587 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.681874e-03 2.572 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 2.894237e-03 2.538 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 3.243751e-03 2.489 0 0
Signaling by SCF-KIT R-HSA-1433557 3.134532e-03 2.504 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.921803e-03 2.534 0 0
Signaling by FGFR4 R-HSA-5654743 3.134532e-03 2.504 0 0
Co-inhibition by BTLA R-HSA-9927353 3.115284e-03 2.507 0 0
DAP12 interactions R-HSA-2172127 3.357592e-03 2.474 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.357592e-03 2.474 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.500059e-03 2.456 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.500059e-03 2.456 0 0
Signaling by FGFR3 R-HSA-5654741 3.591221e-03 2.445 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 4.017716e-03 2.396 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.017716e-03 2.396 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.038110e-03 2.394 0 0
Disease R-HSA-1643685 4.173027e-03 2.380 0 0
Signaling by KIT in disease R-HSA-9669938 4.443194e-03 2.352 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.443194e-03 2.352 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.443194e-03 2.352 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 4.443194e-03 2.352 0 0
Interleukin-20 family signaling R-HSA-8854691 4.894976e-03 2.310 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.214420e-03 2.207 0 0
SOS-mediated signalling R-HSA-112412 6.214420e-03 2.207 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.879205e-03 2.231 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 5.879205e-03 2.231 0 0
Interleukin-6 family signaling R-HSA-6783589 5.373506e-03 2.270 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.879205e-03 2.231 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.412465e-03 2.193 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.412465e-03 2.193 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.574526e-03 2.182 0 0
Signaling by EGFR R-HSA-177929 6.923429e-03 2.160 0 0
Signaling by FGFR1 R-HSA-5654736 6.923429e-03 2.160 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 6.923429e-03 2.160 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 6.923429e-03 2.160 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.973657e-03 2.157 0 0
Transmission across Chemical Synapses R-HSA-112315 7.229578e-03 2.141 0 0
MET receptor recycling R-HSA-8875656 7.462629e-03 2.127 0 0
Formation of annular gap junctions R-HSA-196025 7.462629e-03 2.127 0 0
Interleukin-23 signaling R-HSA-9020933 7.462629e-03 2.127 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.563126e-03 2.121 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.154593e-02 1.938 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.154593e-02 1.938 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.154593e-02 1.938 0 0
KIT mutants bind TKIs R-HSA-9669921 1.154593e-02 1.938 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.154593e-02 1.938 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.154593e-02 1.938 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.154593e-02 1.938 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.154593e-02 1.938 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.154593e-02 1.938 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.154593e-02 1.938 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.154593e-02 1.938 0 0
TLR3 deficiency - HSE R-HSA-5602410 1.154593e-02 1.938 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.154593e-02 1.938 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.154593e-02 1.938 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.154593e-02 1.938 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.154593e-02 1.938 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.154593e-02 1.938 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.154593e-02 1.938 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.154593e-02 1.938 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.154593e-02 1.938 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.154593e-02 1.938 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.154593e-02 1.938 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.154593e-02 1.938 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.154593e-02 1.938 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.154593e-02 1.938 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.154593e-02 1.938 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.154593e-02 1.938 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.154593e-02 1.938 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.154593e-02 1.938 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.154593e-02 1.938 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.154593e-02 1.938 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.154593e-02 1.938 0 0
Gap junction degradation R-HSA-190873 8.814099e-03 2.055 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.026630e-02 1.989 0 0
DAP12 signaling R-HSA-2424491 8.828154e-03 2.054 0 0
PTEN Regulation R-HSA-6807070 1.027393e-02 1.988 0 0
Signaling by PDGF R-HSA-186797 9.394380e-03 2.027 0 0
Nuclear RNA decay R-HSA-9930044 1.094508e-02 1.961 0 0
Signal attenuation R-HSA-74749 1.026630e-02 1.989 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.181192e-03 2.087 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.828154e-03 2.054 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.026630e-02 1.989 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.026630e-02 1.989 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.788577e-03 2.109 0 0
MAPK1 (ERK2) activation R-HSA-112411 8.814099e-03 2.055 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.026630e-02 1.989 0 0
M Phase R-HSA-68886 7.916192e-03 2.101 0 0
Cellular responses to stimuli R-HSA-8953897 9.113177e-03 2.040 0 0
Cellular responses to stress R-HSA-2262752 9.743401e-03 2.011 0 0
Regulation of beta-cell development R-HSA-186712 8.097128e-03 2.092 0 0
Cilium Assembly R-HSA-5617833 1.168039e-02 1.933 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.181677e-02 1.928 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.237828e-02 1.907 0 0
Neuronal System R-HSA-112316 1.241794e-02 1.906 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.284072e-02 1.891 0 0
Hemostasis R-HSA-109582 1.314719e-02 1.881 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 1.333075e-02 1.875 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 1.333075e-02 1.875 0 0
Signaling by NTRKs R-HSA-166520 1.358406e-02 1.867 0 0
RET signaling R-HSA-8853659 1.418655e-02 1.848 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.466954e-02 1.834 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.509585e-02 1.821 0 0
MET activates RAS signaling R-HSA-8851805 1.520275e-02 1.818 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.520275e-02 1.818 0 0
Interleukin-35 Signalling R-HSA-8984722 1.520275e-02 1.818 0 0
Signaling by LTK R-HSA-9842663 1.520275e-02 1.818 0 0
Regulation of IFNG signaling R-HSA-877312 1.520275e-02 1.818 0 0
mRNA Splicing R-HSA-72172 1.645711e-02 1.784 0 0
Signaling by ALK R-HSA-201556 1.693762e-02 1.771 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 1.703352e-02 1.769 0 0
Interleukin-6 signaling R-HSA-1059683 1.703352e-02 1.769 0 0
Cell-Cell communication R-HSA-1500931 1.743635e-02 1.759 0 0
SARS-CoV Infections R-HSA-9679506 1.771244e-02 1.752 0 0
Prolactin receptor signaling R-HSA-1170546 1.895305e-02 1.722 0 0
Regulation of KIT signaling R-HSA-1433559 1.895305e-02 1.722 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.895305e-02 1.722 0 0
Signal regulatory protein family interactions R-HSA-391160 1.895305e-02 1.722 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.295926e-02 1.639 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.295926e-02 1.639 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.295926e-02 1.639 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.295926e-02 1.639 0 0
UNC93B1 deficiency - HSE R-HSA-5602415 2.295926e-02 1.639 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.095907e-02 1.679 0 0
Erythropoietin activates RAS R-HSA-9027284 2.095907e-02 1.679 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 2.095907e-02 1.679 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 2.095907e-02 1.679 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.095907e-02 1.679 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.522170e-02 1.598 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.996613e-02 1.700 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.996613e-02 1.700 0 0
Signaling by FGFR2 R-HSA-5654738 2.001542e-02 1.699 0 0
Metabolism of RNA R-HSA-8953854 2.242088e-02 1.649 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.327351e-02 1.633 0 0
Sensory processing of sound R-HSA-9659379 1.929005e-02 1.715 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 1.996613e-02 1.700 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.095907e-02 1.679 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.553029e-02 1.593 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.553029e-02 1.593 0 0
Signaling by VEGF R-HSA-194138 2.453935e-02 1.610 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.563351e-02 1.591 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.563351e-02 1.591 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.563351e-02 1.591 0 0
Signaling by RAS mutants R-HSA-6802949 2.563351e-02 1.591 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.655117e-02 1.576 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.685998e-02 1.571 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.747396e-02 1.561 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.747396e-02 1.561 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.747396e-02 1.561 0 0
Signaling by Hippo R-HSA-2028269 2.747396e-02 1.561 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 2.747396e-02 1.561 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.980402e-02 1.526 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.980402e-02 1.526 0 0
Platelet sensitization by LDL R-HSA-432142 2.980402e-02 1.526 0 0
Nephron development R-HSA-9831926 2.980402e-02 1.526 0 0
EPH-Ephrin signaling R-HSA-2682334 3.195158e-02 1.496 0 0
Regulation of signaling by CBL R-HSA-912631 3.220980e-02 1.492 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.220980e-02 1.492 0 0
Signaling by NOTCH R-HSA-157118 3.325095e-02 1.478 0 0
mRNA 3'-end processing R-HSA-72187 3.345479e-02 1.476 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.424150e-02 1.465 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.424150e-02 1.465 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.424150e-02 1.465 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.424150e-02 1.465 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.424150e-02 1.465 0 0
Negative regulation of MET activity R-HSA-6807004 3.468927e-02 1.460 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.468927e-02 1.460 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.486568e-02 1.458 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.486568e-02 1.458 0 0
Asparagine N-linked glycosylation R-HSA-446203 3.521376e-02 1.453 0 0
Ribosome-associated quality control R-HSA-9948299 3.563679e-02 1.448 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.598598e-02 1.444 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.598598e-02 1.444 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.724042e-02 1.429 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.724042e-02 1.429 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.724042e-02 1.429 0 0
Signaling by FGFR R-HSA-190236 3.919648e-02 1.407 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.986129e-02 1.399 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.986129e-02 1.399 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.986129e-02 1.399 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.986129e-02 1.399 0 0
Cell-cell junction organization R-HSA-421270 4.007597e-02 1.397 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.068590e-02 1.391 0 0
Regulation of CDH1 Function R-HSA-9764561 4.081193e-02 1.389 0 0
Glycolysis R-HSA-70171 4.142496e-02 1.383 0 0
Innate Immune System R-HSA-168249 4.149066e-02 1.382 0 0
Cell Cycle, Mitotic R-HSA-69278 4.238344e-02 1.373 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.254995e-02 1.371 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 4.254995e-02 1.371 0 0
MET interacts with TNS proteins R-HSA-8875513 5.641868e-02 1.249 0 0
Classical Kir channels R-HSA-1296053 5.641868e-02 1.249 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.530449e-02 1.344 0 0
Signaling by Erythropoietin R-HSA-9006335 6.311347e-02 1.200 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.311347e-02 1.200 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.412529e-02 1.267 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.232509e-02 1.281 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.394500e-02 1.268 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.558543e-02 1.341 0 0
Interferon gamma signaling R-HSA-877300 5.677144e-02 1.246 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.812306e-02 1.318 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.311347e-02 1.200 0 0
Growth hormone receptor signaling R-HSA-982772 4.530449e-02 1.344 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.232509e-02 1.281 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.137802e-02 1.212 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.530449e-02 1.344 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 4.539415e-02 1.343 0 0
MET activates STAT3 R-HSA-8875791 5.641868e-02 1.249 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.694481e-02 1.245 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.694481e-02 1.245 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.232509e-02 1.281 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.609354e-02 1.336 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.723550e-02 1.326 0 0
Signaling by PTK6 R-HSA-8848021 5.062290e-02 1.296 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.062290e-02 1.296 0 0
Parasitic Infection Pathways R-HSA-9824443 6.312190e-02 1.200 0 0
Leishmania infection R-HSA-9658195 6.312190e-02 1.200 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.320224e-02 1.199 0 0
Cell Cycle R-HSA-1640170 4.604394e-02 1.337 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.891472e-02 1.311 0 0
Cell junction organization R-HSA-446728 6.051733e-02 1.218 0 0
Adherens junctions interactions R-HSA-418990 6.059024e-02 1.218 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 5.694481e-02 1.245 0 0
RNA Polymerase II Transcription R-HSA-73857 6.380589e-02 1.195 0 0
Cellular response to chemical stress R-HSA-9711123 5.232124e-02 1.281 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 6.463946e-02 1.190 0 0
Signaling by ROBO receptors R-HSA-376176 4.622841e-02 1.335 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.694481e-02 1.245 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.609374e-02 1.180 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.609374e-02 1.180 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.627896e-02 1.179 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.627896e-02 1.179 0 0
Interleukin-37 signaling R-HSA-9008059 6.627896e-02 1.179 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.726400e-02 1.172 0 0
HCN channels R-HSA-1296061 6.731657e-02 1.172 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 6.731657e-02 1.172 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 6.731657e-02 1.172 0 0
Regulation of gap junction activity R-HSA-191650 6.731657e-02 1.172 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 6.731657e-02 1.172 0 0
Sensory perception of sour taste R-HSA-9729555 6.731657e-02 1.172 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.731657e-02 1.172 0 0
Glucose metabolism R-HSA-70326 6.756501e-02 1.170 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.866470e-02 1.163 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.924957e-02 1.160 0 0
EGFR downregulation R-HSA-182971 6.949635e-02 1.158 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.949635e-02 1.158 0 0
HIV Infection R-HSA-162906 6.971600e-02 1.157 0 0
Signaling by FGFR in disease R-HSA-1226099 7.126155e-02 1.147 0 0
Signaling by NOTCH4 R-HSA-9013694 7.126155e-02 1.147 0 0
Signaling by ERBB4 R-HSA-1236394 7.126155e-02 1.147 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.276406e-02 1.138 0 0
Signaling by Interleukins R-HSA-449147 7.516376e-02 1.124 0 0
UCH proteinases R-HSA-5689603 7.536364e-02 1.123 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.608049e-02 1.119 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.608049e-02 1.119 0 0
Integrin signaling R-HSA-354192 7.608049e-02 1.119 0 0
IRS activation R-HSA-74713 7.808926e-02 1.107 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 7.808926e-02 1.107 0 0
Reelin signalling pathway R-HSA-8866376 7.808926e-02 1.107 0 0
Host Interactions of HIV factors R-HSA-162909 7.833409e-02 1.106 0 0
PCP/CE pathway R-HSA-4086400 7.956809e-02 1.099 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.285338e-02 1.082 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.285338e-02 1.082 0 0
RAF activation R-HSA-5673000 8.285338e-02 1.082 0 0
Signaling by MET R-HSA-6806834 8.387268e-02 1.076 0 0
Signalling to ERKs R-HSA-187687 8.630683e-02 1.064 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 8.827513e-02 1.054 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 8.873818e-02 1.052 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 8.873818e-02 1.052 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 8.873818e-02 1.052 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 8.873818e-02 1.052 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 8.873818e-02 1.052 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 8.873818e-02 1.052 0 0
VEGF ligand-receptor interactions R-HSA-194313 8.873818e-02 1.052 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 9.926475e-02 1.003 0 0
Erythropoietin activates STAT5 R-HSA-9027283 9.926475e-02 1.003 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 1.096704e-01 0.960 0 0
Regulation of PTEN localization R-HSA-8948747 1.096704e-01 0.960 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.096704e-01 0.960 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 1.199564e-01 0.921 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.199564e-01 0.921 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.199564e-01 0.921 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.401752e-01 0.853 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.401752e-01 0.853 0 0
2-LTR circle formation R-HSA-164843 1.401752e-01 0.853 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.401752e-01 0.853 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.501107e-01 0.824 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.501107e-01 0.824 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.501107e-01 0.824 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.599319e-01 0.796 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.599319e-01 0.796 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.696403e-01 0.770 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.696403e-01 0.770 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.696403e-01 0.770 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.696403e-01 0.770 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.696403e-01 0.770 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.696403e-01 0.770 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.696403e-01 0.770 0 0
MET promotes cell motility R-HSA-8875878 9.691777e-02 1.014 0 0
Translation initiation complex formation R-HSA-72649 1.625926e-01 0.789 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.707762e-01 0.768 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.116720e-01 0.952 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.141314e-01 0.943 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.241706e-01 0.906 0 0
Viral mRNA Translation R-HSA-192823 1.478529e-01 0.830 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.615971e-01 0.792 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.599319e-01 0.796 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.792370e-01 0.747 0 0
PI3K/AKT activation R-HSA-198203 1.401752e-01 0.853 0 0
Attenuation phase R-HSA-3371568 1.041865e-01 0.982 0 0
Peptide chain elongation R-HSA-156902 1.044202e-01 0.981 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.334045e-02 1.030 0 0
MAP2K and MAPK activation R-HSA-5674135 1.115986e-01 0.952 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.115986e-01 0.952 0 0
Oncogenic MAPK signaling R-HSA-6802957 9.505716e-02 1.022 0 0
HSF1-dependent transactivation R-HSA-3371571 1.504601e-01 0.823 0 0
MET Receptor Activation R-HSA-6806942 9.926475e-02 1.003 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 1.096704e-01 0.960 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.464581e-01 0.834 0 0
Eukaryotic Translation Termination R-HSA-72764 1.267293e-01 0.897 0 0
Neutrophil degranulation R-HSA-6798695 1.067977e-01 0.971 0 0
ER-Phagosome pathway R-HSA-1236974 1.068161e-01 0.971 0 0
Josephin domain DUBs R-HSA-5689877 1.401752e-01 0.853 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 1.401752e-01 0.853 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.501107e-01 0.824 0 0
Signaling by APC mutants R-HSA-4839744 1.501107e-01 0.824 0 0
Conjugation of benzoate with glycine R-HSA-177135 1.501107e-01 0.824 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.599319e-01 0.796 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.599319e-01 0.796 0 0
ERKs are inactivated R-HSA-202670 1.599319e-01 0.796 0 0
Signaling by AXIN mutants R-HSA-4839735 1.599319e-01 0.796 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.696403e-01 0.770 0 0
Conjugation of salicylate with glycine R-HSA-177128 1.696403e-01 0.770 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.792370e-01 0.747 0 0
Diseases of Immune System R-HSA-5260271 1.041865e-01 0.982 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 1.041865e-01 0.982 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.166112e-01 0.933 0 0
GPVI-mediated activation cascade R-HSA-114604 8.980300e-02 1.047 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 1.696403e-01 0.770 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.268116e-01 0.897 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.786894e-01 0.748 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 1.191112e-01 0.924 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.096704e-01 0.960 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.199564e-01 0.921 0 0
Interleukin-21 signaling R-HSA-9020958 1.301242e-01 0.886 0 0
Interleukin-27 signaling R-HSA-9020956 1.401752e-01 0.853 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.696403e-01 0.770 0 0
Meiotic recombination R-HSA-912446 1.504601e-01 0.823 0 0
Frs2-mediated activation R-HSA-170968 1.792370e-01 0.747 0 0
Co-stimulation by CD28 R-HSA-389356 1.385235e-01 0.858 0 0
Potassium Channels R-HSA-1296071 1.293069e-01 0.888 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.096704e-01 0.960 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 1.599319e-01 0.796 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.792370e-01 0.747 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.153551e-01 0.938 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.306887e-01 0.884 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.790271e-01 0.747 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.643915e-01 0.784 0 0
Selenocysteine synthesis R-HSA-2408557 1.424675e-01 0.846 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.277309e-02 1.033 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.499003e-01 0.824 0 0
G alpha (q) signalling events R-HSA-416476 1.150583e-01 0.939 0 0
Netrin mediated repulsion signals R-HSA-418886 1.096704e-01 0.960 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.301242e-01 0.886 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 1.501107e-01 0.824 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.696403e-01 0.770 0 0
Synthesis of GDP-mannose R-HSA-446205 1.696403e-01 0.770 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.041865e-01 0.982 0 0
Signaling by FGFR2 in disease R-HSA-5655253 1.464581e-01 0.834 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.505704e-01 0.822 0 0
Interleukin-15 signaling R-HSA-8983432 1.696403e-01 0.770 0 0
Toll-like Receptor Cascades R-HSA-168898 9.945915e-02 1.002 0 0
Integration of provirus R-HSA-162592 1.599319e-01 0.796 0 0
HDL clearance R-HSA-8964011 9.926475e-02 1.003 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 1.501107e-01 0.824 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.031316e-01 0.987 0 0
Cyclin D associated events in G1 R-HSA-69231 1.229628e-01 0.910 0 0
G1 Phase R-HSA-69236 1.229628e-01 0.910 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.005336e-01 0.998 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.268116e-01 0.897 0 0
PECAM1 interactions R-HSA-210990 1.501107e-01 0.824 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.691777e-02 1.014 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.792370e-01 0.747 0 0
Signaling by NOTCH3 R-HSA-9012852 1.666755e-01 0.778 0 0
Interleukin-2 signaling R-HSA-9020558 1.501107e-01 0.824 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.199564e-01 0.921 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.319031e-01 0.880 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.615971e-01 0.792 0 0
Signaling by ALK in cancer R-HSA-9700206 1.615971e-01 0.792 0 0
Gene expression (Transcription) R-HSA-74160 1.640417e-01 0.785 0 0
Phospholipid metabolism R-HSA-1483257 1.620803e-01 0.790 0 0
TCR signaling R-HSA-202403 1.700233e-01 0.769 0 0
Apoptotic execution phase R-HSA-75153 1.306887e-01 0.884 0 0
Generic Transcription Pathway R-HSA-212436 1.487735e-01 0.827 0 0
FOXO-mediated transcription R-HSA-9614085 1.371500e-01 0.863 0 0
Programmed Cell Death R-HSA-5357801 1.230071e-01 0.910 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.873379e-01 0.727 0 0
Signaling by ERBB2 R-HSA-1227986 1.873379e-01 0.727 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.873379e-01 0.727 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.887235e-01 0.724 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.887235e-01 0.724 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.887235e-01 0.724 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.887235e-01 0.724 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 1.901531e-01 0.721 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 1.919674e-01 0.717 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.957015e-01 0.708 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.957015e-01 0.708 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.981008e-01 0.703 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.981008e-01 0.703 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.981008e-01 0.703 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.981008e-01 0.703 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.981008e-01 0.703 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.981008e-01 0.703 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.981008e-01 0.703 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.981008e-01 0.703 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.981008e-01 0.703 0 0
Influenza Infection R-HSA-168255 1.996285e-01 0.700 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.999010e-01 0.699 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.999010e-01 0.699 0 0
Negative regulation of FLT3 R-HSA-9706369 2.073704e-01 0.683 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.073704e-01 0.683 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.073704e-01 0.683 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.073704e-01 0.683 0 0
Prolonged ERK activation events R-HSA-169893 2.073704e-01 0.683 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.073704e-01 0.683 0 0
Differentiation of T cells R-HSA-9945266 2.073704e-01 0.683 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 2.073704e-01 0.683 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.125607e-01 0.673 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 2.165333e-01 0.664 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.165333e-01 0.664 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.165333e-01 0.664 0 0
Kidney development R-HSA-9830369 2.167983e-01 0.664 0 0
Deubiquitination R-HSA-5688426 2.169864e-01 0.664 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.190639e-01 0.659 0 0
Regulated Necrosis R-HSA-5218859 2.210435e-01 0.656 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.212667e-01 0.655 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.255909e-01 0.647 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.295538e-01 0.639 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.295538e-01 0.639 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.295538e-01 0.639 0 0
Developmental Cell Lineages R-HSA-9734767 2.337756e-01 0.631 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.338174e-01 0.631 0 0
Hedgehog 'on' state R-HSA-5632684 2.338174e-01 0.631 0 0
Retinoid metabolism and transport R-HSA-975634 2.338174e-01 0.631 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.345444e-01 0.630 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.345444e-01 0.630 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 2.345444e-01 0.630 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.423583e-01 0.616 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.433948e-01 0.614 0 0
Conjugation of carboxylic acids R-HSA-159424 2.433948e-01 0.614 0 0
Amino Acid conjugation R-HSA-156587 2.433948e-01 0.614 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.433948e-01 0.614 0 0
Other interleukin signaling R-HSA-449836 2.433948e-01 0.614 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.433948e-01 0.614 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 2.466342e-01 0.608 0 0
Centrosome maturation R-HSA-380287 2.509128e-01 0.600 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.509128e-01 0.600 1 1
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.521435e-01 0.598 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.521435e-01 0.598 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.521435e-01 0.598 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.521435e-01 0.598 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.521435e-01 0.598 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.521435e-01 0.598 0 0
Protein hydroxylation R-HSA-9629569 2.521435e-01 0.598 0 0
Signal transduction by L1 R-HSA-445144 2.521435e-01 0.598 0 0
Interleukin-12 signaling R-HSA-9020591 2.551936e-01 0.593 0 0
Signaling by NOTCH1 R-HSA-1980143 2.551936e-01 0.593 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.585850e-01 0.587 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.607916e-01 0.584 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 2.607916e-01 0.584 0 0
Signalling to RAS R-HSA-167044 2.607916e-01 0.584 0 0
ERK/MAPK targets R-HSA-198753 2.607916e-01 0.584 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.607916e-01 0.584 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.607916e-01 0.584 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.628737e-01 0.580 0 0
Integration of energy metabolism R-HSA-163685 2.628737e-01 0.580 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.693401e-01 0.570 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.693401e-01 0.570 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.693401e-01 0.570 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 2.693401e-01 0.570 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.693401e-01 0.570 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.693401e-01 0.570 0 0
Translation R-HSA-72766 2.698212e-01 0.569 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 2.766087e-01 0.558 0 0
Notch-HLH transcription pathway R-HSA-350054 2.777904e-01 0.556 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.777904e-01 0.556 0 0
LDL clearance R-HSA-8964038 2.777904e-01 0.556 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 2.777904e-01 0.556 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.777904e-01 0.556 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 2.777904e-01 0.556 0 0
Cytoprotection by HMOX1 R-HSA-9707564 2.851691e-01 0.545 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.861434e-01 0.543 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.861434e-01 0.543 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.867010e-01 0.543 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.894460e-01 0.538 0 0
Meiosis R-HSA-1500620 2.937200e-01 0.532 0 0
Deadenylation of mRNA R-HSA-429947 2.944003e-01 0.531 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 2.944003e-01 0.531 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.973571e-01 0.527 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.979905e-01 0.526 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.979905e-01 0.526 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.979905e-01 0.526 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.025622e-01 0.519 0 0
G protein gated Potassium channels R-HSA-1296059 3.025622e-01 0.519 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 3.025622e-01 0.519 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 3.025622e-01 0.519 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.025622e-01 0.519 0 0
Long-term potentiation R-HSA-9620244 3.025622e-01 0.519 0 0
Tight junction interactions R-HSA-420029 3.025622e-01 0.519 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.025622e-01 0.519 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.025622e-01 0.519 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.025622e-01 0.519 0 0
Interleukin-7 signaling R-HSA-1266695 3.025622e-01 0.519 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.036629e-01 0.518 0 0
Interleukin-12 family signaling R-HSA-447115 3.065193e-01 0.514 0 0
Pyruvate metabolism R-HSA-70268 3.065193e-01 0.514 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.099751e-01 0.509 0 0
MET activates PTK2 signaling R-HSA-8874081 3.106302e-01 0.508 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.106302e-01 0.508 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 3.106302e-01 0.508 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.106302e-01 0.508 0 0
Interleukin-1 family signaling R-HSA-446652 3.162918e-01 0.500 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.186054e-01 0.497 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.186054e-01 0.497 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 3.186054e-01 0.497 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.186054e-01 0.497 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 3.186054e-01 0.497 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.192750e-01 0.496 0 0
Downstream TCR signaling R-HSA-202424 3.192750e-01 0.496 0 0
Protein localization R-HSA-9609507 3.194513e-01 0.496 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.256825e-01 0.487 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.257714e-01 0.487 0 0
HIV elongation arrest and recovery R-HSA-167287 3.264888e-01 0.486 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.264888e-01 0.486 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.264888e-01 0.486 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.264888e-01 0.486 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 3.282977e-01 0.484 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 3.319750e-01 0.479 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.342815e-01 0.476 0 0
DARPP-32 events R-HSA-180024 3.342815e-01 0.476 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.342815e-01 0.476 0 0
Cellular response to starvation R-HSA-9711097 3.352513e-01 0.475 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.358023e-01 0.474 0 0
rRNA processing R-HSA-72312 3.361510e-01 0.473 0 0
Mitochondrial protein degradation R-HSA-9837999 3.404053e-01 0.468 0 0
Chromatin modifying enzymes R-HSA-3247509 3.413914e-01 0.467 0 0
Signaling by TGFB family members R-HSA-9006936 3.415687e-01 0.467 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.419845e-01 0.466 0 0
Apoptosis R-HSA-109581 3.478820e-01 0.459 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.495988e-01 0.456 0 0
Trafficking of AMPA receptors R-HSA-399719 3.495988e-01 0.456 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 3.495988e-01 0.456 0 0
Cargo concentration in the ER R-HSA-5694530 3.495988e-01 0.456 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.495988e-01 0.456 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 3.529884e-01 0.452 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.529884e-01 0.452 0 0
Selenoamino acid metabolism R-HSA-2408522 3.541897e-01 0.451 0 0
Signaling by WNT in cancer R-HSA-4791275 3.571255e-01 0.447 0 0
Inwardly rectifying K+ channels R-HSA-1296065 3.571255e-01 0.447 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.571255e-01 0.447 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.571255e-01 0.447 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.645655e-01 0.438 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.645655e-01 0.438 0 0
G-protein beta:gamma signalling R-HSA-397795 3.645655e-01 0.438 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.645655e-01 0.438 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.645655e-01 0.438 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.645655e-01 0.438 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.645655e-01 0.438 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.645655e-01 0.438 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.696344e-01 0.432 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.719199e-01 0.430 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.719199e-01 0.430 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.719199e-01 0.430 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.719199e-01 0.430 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.719199e-01 0.430 0 0
Heme degradation R-HSA-189483 3.719199e-01 0.430 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.778951e-01 0.423 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.791896e-01 0.421 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.791896e-01 0.421 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.791896e-01 0.421 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.791896e-01 0.421 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.791896e-01 0.421 0 0
Mitophagy R-HSA-5205647 3.791896e-01 0.421 0 0
RA biosynthesis pathway R-HSA-5365859 3.791896e-01 0.421 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 3.791896e-01 0.421 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.791896e-01 0.421 0 0
Chromatin organization R-HSA-4839726 3.807166e-01 0.419 0 0
Ub-specific processing proteases R-HSA-5689880 3.855911e-01 0.414 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.861110e-01 0.413 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.863757e-01 0.413 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.863757e-01 0.413 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.863757e-01 0.413 0 0
Regulation of Apoptosis R-HSA-169911 3.863757e-01 0.413 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.863757e-01 0.413 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 3.863757e-01 0.413 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.918339e-01 0.407 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.934789e-01 0.405 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.934789e-01 0.405 0 0
HSF1 activation R-HSA-3371511 3.934789e-01 0.405 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.934789e-01 0.405 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.934789e-01 0.405 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.942798e-01 0.404 0 0
Nucleotide Excision Repair R-HSA-5696398 3.942798e-01 0.404 0 0
Platelet homeostasis R-HSA-418346 3.983458e-01 0.400 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.983458e-01 0.400 0 0
Degradation of DVL R-HSA-4641258 4.005004e-01 0.397 0 0
Degradation of AXIN R-HSA-4641257 4.005004e-01 0.397 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.005004e-01 0.397 0 0
NCAM1 interactions R-HSA-419037 4.005004e-01 0.397 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.005004e-01 0.397 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.005004e-01 0.397 0 0
Respiratory electron transport R-HSA-611105 4.011683e-01 0.397 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.074411e-01 0.390 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 4.090744e-01 0.388 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 4.143018e-01 0.383 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.143018e-01 0.383 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.143018e-01 0.383 0 0
Stabilization of p53 R-HSA-69541 4.143018e-01 0.383 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.143018e-01 0.383 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.144817e-01 0.382 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.144817e-01 0.382 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.210835e-01 0.376 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.210835e-01 0.376 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.210835e-01 0.376 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 4.210835e-01 0.376 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.210835e-01 0.376 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.210835e-01 0.376 0 0
HIV Transcription Elongation R-HSA-167169 4.210835e-01 0.376 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.210835e-01 0.376 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.210835e-01 0.376 0 0
Generation of second messenger molecules R-HSA-202433 4.210835e-01 0.376 0 0
FCERI mediated MAPK activation R-HSA-2871796 4.224694e-01 0.374 0 0
Inositol phosphate metabolism R-HSA-1483249 4.224694e-01 0.374 0 0
Peptide ligand-binding receptors R-HSA-375276 4.258557e-01 0.371 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.277871e-01 0.369 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.277871e-01 0.369 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 4.277871e-01 0.369 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.277871e-01 0.369 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.304011e-01 0.366 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.344134e-01 0.362 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.344134e-01 0.362 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.344134e-01 0.362 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.344134e-01 0.362 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.382752e-01 0.358 0 0
Activation of GABAB receptors R-HSA-991365 4.409635e-01 0.356 0 0
GABA B receptor activation R-HSA-977444 4.409635e-01 0.356 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.409635e-01 0.356 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.455638e-01 0.351 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.474381e-01 0.349 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.474381e-01 0.349 0 0
Proteasome assembly R-HSA-9907900 4.538381e-01 0.343 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.538381e-01 0.343 0 0
RMTs methylate histone arginines R-HSA-3214858 4.538381e-01 0.343 0 0
Netrin-1 signaling R-HSA-373752 4.538381e-01 0.343 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.576989e-01 0.339 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.576989e-01 0.339 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.601643e-01 0.337 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.601643e-01 0.337 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.601643e-01 0.337 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.601643e-01 0.337 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.601643e-01 0.337 0 0
Somitogenesis R-HSA-9824272 4.601643e-01 0.337 0 0
Mitotic Prophase R-HSA-68875 4.615374e-01 0.336 0 0
Cellular response to heat stress R-HSA-3371556 4.653601e-01 0.332 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.659210e-01 0.332 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.664177e-01 0.331 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.664177e-01 0.331 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.664177e-01 0.331 0 0
Diseases of DNA repair R-HSA-9675135 4.664177e-01 0.331 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.664177e-01 0.331 0 0
Co-inhibition by PD-1 R-HSA-389948 4.681622e-01 0.330 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.691668e-01 0.329 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.691668e-01 0.329 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.725990e-01 0.326 0 0
Formation of the cornified envelope R-HSA-6809371 4.767319e-01 0.322 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.787091e-01 0.320 0 0
Gluconeogenesis R-HSA-70263 4.787091e-01 0.320 0 0
G1/S Transition R-HSA-69206 4.842316e-01 0.315 0 0
Degradation of CDH1 R-HSA-9766229 4.847488e-01 0.314 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.847488e-01 0.314 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.847488e-01 0.314 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.847488e-01 0.314 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 4.907188e-01 0.309 0 0
Complex IV assembly R-HSA-9864848 4.966201e-01 0.304 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.966201e-01 0.304 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.966201e-01 0.304 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.966201e-01 0.304 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.024533e-01 0.299 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.024533e-01 0.299 0 0
Orc1 removal from chromatin R-HSA-68949 5.024533e-01 0.299 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.024533e-01 0.299 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.024533e-01 0.299 0 0
Signaling by WNT R-HSA-195721 5.057982e-01 0.296 0 0
Reproduction R-HSA-1474165 5.063288e-01 0.296 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.082193e-01 0.294 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.082193e-01 0.294 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.082193e-01 0.294 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.082193e-01 0.294 0 0
Cardiac conduction R-HSA-5576891 5.099520e-01 0.292 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.139188e-01 0.289 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.139188e-01 0.289 0 0
HDACs deacetylate histones R-HSA-3214815 5.195527e-01 0.284 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.195527e-01 0.284 0 0
Paracetamol ADME R-HSA-9753281 5.195527e-01 0.284 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.251215e-01 0.280 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.251215e-01 0.280 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.251215e-01 0.280 0 0
Dectin-2 family R-HSA-5621480 5.306262e-01 0.275 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.348245e-01 0.272 0 0
Dual incision in TC-NER R-HSA-6782135 5.360674e-01 0.271 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 5.360674e-01 0.271 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.414459e-01 0.266 0 0
Peroxisomal protein import R-HSA-9033241 5.414459e-01 0.266 0 0
RAB geranylgeranylation R-HSA-8873719 5.467623e-01 0.262 0 0
GABA receptor activation R-HSA-977443 5.467623e-01 0.262 0 0
Glutathione conjugation R-HSA-156590 5.467623e-01 0.262 0 0
Metabolism of polyamines R-HSA-351202 5.467623e-01 0.262 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.467623e-01 0.262 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.467623e-01 0.262 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.467623e-01 0.262 0 0
Signaling by Retinoic Acid R-HSA-5362517 5.467623e-01 0.262 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.467623e-01 0.262 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.467623e-01 0.262 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.520174e-01 0.258 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.520174e-01 0.258 0 0
MAP kinase activation R-HSA-450294 5.520174e-01 0.258 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.554499e-01 0.255 0 0
Mitochondrial protein import R-HSA-1268020 5.572119e-01 0.254 0 0
tRNA processing in the nucleus R-HSA-6784531 5.572119e-01 0.254 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.572119e-01 0.254 0 0
Complex I biogenesis R-HSA-6799198 5.623465e-01 0.250 0 0
Semaphorin interactions R-HSA-373755 5.623465e-01 0.250 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.623465e-01 0.250 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.674219e-01 0.246 0 0
Visual phototransduction R-HSA-2187338 5.721401e-01 0.242 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.724387e-01 0.242 0 0
Cellular response to hypoxia R-HSA-1234174 5.724387e-01 0.242 0 0
Cell surface interactions at the vascular wall R-HSA-202733 5.751069e-01 0.240 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.822994e-01 0.235 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 5.822994e-01 0.235 0 0
Post-translational protein modification R-HSA-597592 5.836446e-01 0.234 0 0
Transcription of the HIV genome R-HSA-167172 5.871445e-01 0.231 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.915657e-01 0.228 0 0
COPII-mediated vesicle transport R-HSA-204005 5.966678e-01 0.224 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.966678e-01 0.224 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 5.966678e-01 0.224 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.966678e-01 0.224 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.966678e-01 0.224 0 0
Interleukin-17 signaling R-HSA-448424 5.966678e-01 0.224 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.013472e-01 0.221 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.013472e-01 0.221 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.013472e-01 0.221 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.013472e-01 0.221 0 0
Metabolism of porphyrins R-HSA-189445 6.013472e-01 0.221 0 0
HCMV Late Events R-HSA-9610379 6.041494e-01 0.219 0 0
HIV Life Cycle R-HSA-162587 6.041494e-01 0.219 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.059726e-01 0.218 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 6.059726e-01 0.218 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.059726e-01 0.218 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.105446e-01 0.214 0 0
Aspirin ADME R-HSA-9749641 6.105446e-01 0.214 0 0
Regulation of TP53 Activity R-HSA-5633007 6.133946e-01 0.212 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 6.150638e-01 0.211 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.195309e-01 0.208 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 6.195309e-01 0.208 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.195309e-01 0.208 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.228540e-01 0.206 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.239464e-01 0.205 0 0
Cell Cycle Checkpoints R-HSA-69620 6.281890e-01 0.202 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.326250e-01 0.199 0 0
G alpha (12/13) signalling events R-HSA-416482 6.326250e-01 0.199 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.326250e-01 0.199 0 0
RNA Polymerase I Transcription R-HSA-73864 6.326250e-01 0.199 0 0
Cholesterol biosynthesis R-HSA-191273 6.326250e-01 0.199 0 0
ABC transporter disorders R-HSA-5619084 6.326250e-01 0.199 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.411045e-01 0.193 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.411045e-01 0.193 0 0
Amyloid fiber formation R-HSA-977225 6.452709e-01 0.190 0 0
DNA Repair R-HSA-73894 6.457167e-01 0.190 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.487311e-01 0.188 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.515579e-01 0.186 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.534599e-01 0.185 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.574837e-01 0.182 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.614609e-01 0.179 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.692782e-01 0.174 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 6.692782e-01 0.174 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.814723e-01 0.167 0 0
FCGR activation R-HSA-2029481 6.987920e-01 0.156 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.987920e-01 0.156 0 0
Metabolism of proteins R-HSA-392499 7.049345e-01 0.152 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.057515e-01 0.151 0 0
Scavenging of heme from plasma R-HSA-2168880 7.091711e-01 0.149 0 0
Mitochondrial translation elongation R-HSA-5389840 7.125511e-01 0.147 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 7.158920e-01 0.145 0 0
Mitochondrial translation initiation R-HSA-5368286 7.191943e-01 0.143 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.191943e-01 0.143 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.191943e-01 0.143 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.191943e-01 0.143 0 0
Synthesis of bile acids and bile salts R-HSA-192105 7.224585e-01 0.141 0 0
HATs acetylate histones R-HSA-3214847 7.224585e-01 0.141 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.224585e-01 0.141 0 0
ABC-family proteins mediated transport R-HSA-382556 7.256849e-01 0.139 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.288739e-01 0.137 0 0
Interleukin-1 signaling R-HSA-9020702 7.288739e-01 0.137 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.320261e-01 0.135 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 7.351419e-01 0.134 0 0
Opioid Signalling R-HSA-111885 7.382216e-01 0.132 0 0
Keratinization R-HSA-6805567 7.394878e-01 0.131 0 0
RSV-host interactions R-HSA-9833110 7.412657e-01 0.130 0 0
Synthesis of DNA R-HSA-69239 7.501883e-01 0.125 0 0
Muscle contraction R-HSA-397014 7.525127e-01 0.123 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.530940e-01 0.123 0 0
Mitochondrial translation termination R-HSA-5419276 7.559660e-01 0.121 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.559660e-01 0.121 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.559660e-01 0.121 0 0
Bile acid and bile salt metabolism R-HSA-194068 7.588048e-01 0.120 0 0
Drug ADME R-HSA-9748784 7.649759e-01 0.116 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.671256e-01 0.115 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.698353e-01 0.114 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.777776e-01 0.109 0 0
Interferon alpha/beta signaling R-HSA-909733 7.777776e-01 0.109 0 0
Homology Directed Repair R-HSA-5693538 7.854472e-01 0.105 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.879447e-01 0.104 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.928535e-01 0.101 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.976491e-01 0.098 0 0
ESR-mediated signaling R-HSA-8939211 8.009236e-01 0.096 0 0
Phase II - Conjugation of compounds R-HSA-156580 8.044110e-01 0.095 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 8.056453e-01 0.094 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 8.069117e-01 0.093 0 0
Platelet degranulation R-HSA-114608 8.091606e-01 0.092 0 0
G2/M Checkpoints R-HSA-69481 8.091606e-01 0.092 0 0
Adipogenesis R-HSA-9843745 8.200206e-01 0.086 0 0
Sensory perception of taste R-HSA-9717189 8.200206e-01 0.086 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 8.200206e-01 0.086 0 0
GPCR downstream signalling R-HSA-388396 8.204038e-01 0.086 0 0
Circadian clock R-HSA-9909396 8.221176e-01 0.085 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.238484e-01 0.084 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.241904e-01 0.084 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.322439e-01 0.080 0 0
Mitochondrial translation R-HSA-5368287 8.361320e-01 0.078 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.454645e-01 0.073 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.490477e-01 0.071 0 0
S Phase R-HSA-69242 8.559681e-01 0.068 0 0
Gastrulation R-HSA-9758941 8.576483e-01 0.067 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 8.593090e-01 0.066 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.609504e-01 0.065 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.625728e-01 0.064 0 0
Arachidonate metabolism R-HSA-2142753 8.625728e-01 0.064 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 8.627081e-01 0.064 0 0
DNA Replication R-HSA-69306 8.641763e-01 0.063 0 0
Death Receptor Signaling R-HSA-73887 8.657613e-01 0.063 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 8.704066e-01 0.060 0 0
G alpha (i) signalling events R-HSA-418594 8.762256e-01 0.057 0 0
Signaling by GPCR R-HSA-372790 8.884970e-01 0.051 0 0
tRNA processing R-HSA-72306 8.900567e-01 0.051 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.938652e-01 0.049 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.938652e-01 0.049 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.095440e-01 0.041 0 0
Metabolism of steroids R-HSA-8957322 9.103972e-01 0.041 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.151172e-01 0.039 0 0
Extracellular matrix organization R-HSA-1474244 9.161629e-01 0.038 1 0
Metabolism of vitamins and cofactors R-HSA-196854 9.389612e-01 0.027 0 0
Neddylation R-HSA-8951664 9.403836e-01 0.027 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.412697e-01 0.026 0 0
Bacterial Infection Pathways R-HSA-9824439 9.531224e-01 0.021 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.561331e-01 0.019 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.562488e-01 0.019 0 0
Fatty acid metabolism R-HSA-8978868 9.603726e-01 0.018 0 0
GPCR ligand binding R-HSA-500792 9.741881e-01 0.011 0 0
Biological oxidations R-HSA-211859 9.878025e-01 0.005 0 0
Transport of small molecules R-HSA-382551 9.917607e-01 0.004 0 0
Sensory Perception R-HSA-9709957 9.921944e-01 0.003 0 0
Metabolism of lipids R-HSA-556833 9.929493e-01 0.003 0 0
Metabolism R-HSA-1430728 9.997845e-01 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.874678e-14 13.412 0 0
Packaging Of Telomere Ends R-HSA-171306 1.075806e-13 12.968 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.075806e-13 12.968 0 0
DNA methylation R-HSA-5334118 2.018385e-13 12.695 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.855005e-13 12.314 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.402656e-13 12.194 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.090239e-12 11.962 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.090239e-12 11.962 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.808442e-12 11.743 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.308154e-12 11.637 0 0
Cleavage of the damaged purine R-HSA-110331 2.308154e-12 11.637 0 0
Depurination R-HSA-73927 2.929101e-12 11.533 0 0
Meiotic synapsis R-HSA-1221632 3.571698e-12 11.447 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.642065e-12 11.333 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 4.642065e-12 11.333 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.799805e-12 11.237 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.799805e-12 11.237 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.926193e-12 11.049 0 0
Depyrimidination R-HSA-73928 8.926193e-12 11.049 0 0
Defective pyroptosis R-HSA-9710421 1.099987e-11 10.959 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.649647e-11 10.783 0 0
Nucleosome assembly R-HSA-774815 1.649647e-11 10.783 0 0
HCMV Early Events R-HSA-9609690 1.870137e-11 10.728 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.008205e-11 10.697 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.942968e-11 10.531 0 0
Signal Transduction R-HSA-162582 2.992229e-11 10.524 0 0
Meiotic recombination R-HSA-912446 5.086864e-11 10.294 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.065437e-11 10.217 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 7.210188e-11 10.142 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.801926e-11 10.108 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.545697e-11 10.068 0 0
HDACs deacetylate histones R-HSA-3214815 1.009963e-10 9.996 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.141458e-10 9.943 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.640230e-10 9.785 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.918072e-10 9.717 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.237490e-10 9.650 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.237490e-10 9.650 0 0
Axon guidance R-HSA-422475 2.783591e-10 9.555 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.023313e-10 9.520 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.023313e-10 9.520 0 0
M Phase R-HSA-68886 3.279749e-10 9.484 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.749444e-10 9.426 0 0
Meiosis R-HSA-1500620 4.230817e-10 9.374 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.375729e-10 9.270 0 0
Cell-Cell communication R-HSA-1500931 5.152396e-10 9.288 0 0
Gene Silencing by RNA R-HSA-211000 5.728433e-10 9.242 0 0
DNA Double Strand Break Response R-HSA-5693606 6.175660e-10 9.209 0 0
Diseases of programmed cell death R-HSA-9645723 6.766336e-10 9.170 0 0
HCMV Infection R-HSA-9609646 6.920304e-10 9.160 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.080764e-10 9.150 0 0
Base Excision Repair R-HSA-73884 8.490773e-10 9.071 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.255792e-10 9.034 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.255792e-10 9.034 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.055339e-09 8.977 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.055339e-09 8.977 0 0
Nervous system development R-HSA-9675108 1.045842e-09 8.981 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.317758e-09 8.880 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.548141e-09 8.810 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.982318e-09 8.703 0 0
Telomere Maintenance R-HSA-157579 2.225639e-09 8.653 0 0
RNA Polymerase I Transcription R-HSA-73864 2.522477e-09 8.598 0 0
Cell Cycle, Mitotic R-HSA-69278 2.904212e-09 8.537 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.043319e-09 8.517 0 0
Cell junction organization R-HSA-446728 3.185765e-09 8.497 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.190782e-09 8.496 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.580960e-09 8.446 0 0
Amyloid fiber formation R-HSA-977225 3.580960e-09 8.446 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.013274e-09 8.397 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.750065e-09 8.111 0 0
Developmental Biology R-HSA-1266738 1.120785e-08 7.950 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.169640e-08 7.932 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.204785e-08 7.919 0 0
ESR-mediated signaling R-HSA-8939211 1.651155e-08 7.782 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.919711e-08 7.717 0 0
Homology Directed Repair R-HSA-5693538 1.995489e-08 7.700 0 0
Chromosome Maintenance R-HSA-73886 2.544000e-08 7.594 0 0
HATs acetylate histones R-HSA-3214847 3.052098e-08 7.515 0 0
Cell-cell junction organization R-HSA-421270 3.404247e-08 7.468 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.994946e-08 7.398 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.994946e-08 7.398 0 0
DNA Replication R-HSA-69306 4.006822e-08 7.397 0 0
Adherens junctions interactions R-HSA-418990 4.033439e-08 7.394 0 0
G2/M Checkpoints R-HSA-69481 4.383180e-08 7.358 0 0
Cell Cycle R-HSA-1640170 4.821456e-08 7.317 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.188665e-08 7.285 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.188665e-08 7.285 0 0
Reproduction R-HSA-1474165 5.902431e-08 7.229 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.034913e-08 7.153 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.848545e-08 7.105 0 0
Post NMDA receptor activation events R-HSA-438064 9.054727e-08 7.043 0 0
Viral Infection Pathways R-HSA-9824446 1.006776e-07 6.997 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.089282e-07 6.963 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.345673e-07 6.871 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.398324e-07 6.854 0 0
Ub-specific processing proteases R-HSA-5689880 1.496766e-07 6.825 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.496766e-07 6.825 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.496766e-07 6.825 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.535108e-07 6.814 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.987174e-07 6.702 0 0
Mitotic Prophase R-HSA-68875 2.159738e-07 6.666 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.648151e-07 6.577 0 0
Protein ubiquitination R-HSA-8852135 2.904402e-07 6.537 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.145450e-07 6.502 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.221382e-07 6.492 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.314403e-07 6.480 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.314403e-07 6.480 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.314403e-07 6.480 0 0
Cellular responses to stress R-HSA-2262752 3.881147e-07 6.411 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.974237e-07 6.401 0 0
Co-inhibition by PD-1 R-HSA-389948 6.502532e-07 6.187 0 0
Aggrephagy R-HSA-9646399 7.904389e-07 6.102 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.214504e-07 6.036 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.214504e-07 6.036 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.061531e-07 6.043 0 0
Signaling by PTK6 R-HSA-8848021 1.015120e-06 5.993 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.015120e-06 5.993 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.919549e-07 6.004 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.043428e-06 5.982 0 0
Deubiquitination R-HSA-5688426 1.438931e-06 5.842 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.575001e-06 5.803 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.886691e-06 5.724 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.046614e-06 5.689 0 0
Infectious disease R-HSA-5663205 2.194872e-06 5.659 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.225910e-06 5.652 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.397996e-06 5.620 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.613285e-06 5.583 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.053903e-06 5.515 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.165915e-06 5.500 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.319448e-06 5.479 0 0
Cellular responses to stimuli R-HSA-8953897 4.063349e-06 5.391 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.116993e-06 5.385 0 0
Signaling by NOTCH R-HSA-157118 4.194133e-06 5.377 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.346632e-06 5.272 0 0
PKR-mediated signaling R-HSA-9833482 4.868859e-06 5.313 0 0
Gap junction assembly R-HSA-190861 5.463177e-06 5.263 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.900279e-06 5.102 0 0
Signaling by ERBB2 R-HSA-1227986 8.737284e-06 5.059 0 0
Cellular Senescence R-HSA-2559583 9.373369e-06 5.028 0 0
L1CAM interactions R-HSA-373760 1.087059e-05 4.964 0 0
G2/M Transition R-HSA-69275 1.231931e-05 4.909 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.264465e-05 4.898 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.346571e-05 4.871 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.486409e-05 4.828 0 0
HCMV Late Events R-HSA-9610379 1.817920e-05 4.740 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.968849e-05 4.706 0 0
Gap junction trafficking R-HSA-190828 2.069299e-05 4.684 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.069299e-05 4.684 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.544091e-05 4.594 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.823743e-05 4.549 0 0
Recycling pathway of L1 R-HSA-437239 2.823743e-05 4.549 0 0
Signaling by WNT R-HSA-195721 3.421640e-05 4.466 0 0
Gap junction trafficking and regulation R-HSA-157858 3.439260e-05 4.464 0 0
Cell Cycle Checkpoints R-HSA-69620 4.122354e-05 4.385 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.333472e-05 4.363 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.464375e-05 4.350 0 0
Adaptive Immune System R-HSA-1280218 4.874777e-05 4.312 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.808680e-05 4.107 0 0
Kinesins R-HSA-983189 9.024547e-05 4.045 0 0
Disease R-HSA-1643685 9.289432e-05 4.032 0 0
Selective autophagy R-HSA-9663891 8.163797e-05 4.088 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.322363e-05 4.030 0 0
Chromatin modifying enzymes R-HSA-3247509 8.413936e-05 4.075 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.329861e-05 4.030 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.093379e-04 3.961 0 0
MHC class II antigen presentation R-HSA-2132295 1.093379e-04 3.961 0 0
EPH-Ephrin signaling R-HSA-2682334 1.111417e-04 3.954 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.139710e-04 3.943 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.139710e-04 3.943 0 0
Semaphorin interactions R-HSA-373755 1.139710e-04 3.943 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.251372e-04 3.903 0 0
Signaling by VEGF R-HSA-194138 1.266578e-04 3.897 0 0
Chromatin organization R-HSA-4839726 1.384082e-04 3.859 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.424007e-04 3.846 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.839143e-04 3.735 0 0
DNA Repair R-HSA-73894 1.991540e-04 3.701 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 2.020032e-04 3.695 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.274164e-04 3.643 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.307275e-04 3.637 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.307275e-04 3.637 0 0
Centrosome maturation R-HSA-380287 2.625752e-04 3.581 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.661918e-04 3.575 0 0
Intraflagellar transport R-HSA-5620924 3.339384e-04 3.476 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.789732e-04 3.421 0 0
Cilium Assembly R-HSA-5617833 3.886913e-04 3.410 0 0
Mitotic Prometaphase R-HSA-68877 4.303829e-04 3.366 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.321511e-04 3.364 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.457307e-04 3.351 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.510477e-04 3.346 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.553989e-04 3.342 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.769597e-04 3.322 0 0
Smooth Muscle Contraction R-HSA-445355 4.912187e-04 3.309 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.212350e-04 3.283 0 0
Autophagy R-HSA-9612973 5.358327e-04 3.271 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.359193e-04 3.271 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.380805e-04 3.269 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.627855e-04 3.250 0 0
DAP12 signaling R-HSA-2424491 5.974262e-04 3.224 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.421374e-04 3.075 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.421374e-04 3.075 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.421374e-04 3.075 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.421374e-04 3.075 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.421374e-04 3.075 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.421374e-04 3.075 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.421374e-04 3.075 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.421374e-04 3.075 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.421374e-04 3.075 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.421374e-04 3.075 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.421374e-04 3.075 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.598542e-04 3.181 0 0
Protein folding R-HSA-391251 7.694220e-04 3.114 0 0
Immune System R-HSA-168256 7.991678e-04 3.097 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.827045e-04 3.008 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.011413e-03 2.995 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.039338e-03 2.983 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.102536e-03 2.958 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.135535e-03 2.945 0 0
GPVI-mediated activation cascade R-HSA-114604 1.149407e-03 2.940 0 0
Hedgehog 'off' state R-HSA-5610787 1.183899e-03 2.927 0 0
TRKA activation by NGF R-HSA-187042 1.306861e-03 2.884 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.466149e-03 2.834 0 0
Macroautophagy R-HSA-1632852 1.466588e-03 2.834 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.588660e-03 2.799 0 0
MAPK family signaling cascades R-HSA-5683057 1.768047e-03 2.753 0 0
Signaling by ERBB4 R-HSA-1236394 1.810894e-03 2.742 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.825046e-03 2.739 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.869048e-03 2.728 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.881088e-03 2.726 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.897135e-03 2.722 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.280984e-03 2.642 0 0
DAP12 interactions R-HSA-2172127 2.286798e-03 2.641 0 0
Nephrin family interactions R-HSA-373753 2.399582e-03 2.620 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.410833e-03 2.618 0 0
Post-translational protein modification R-HSA-597592 2.449458e-03 2.611 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.793983e-03 2.554 0 0
Gluconeogenesis R-HSA-70263 2.978839e-03 2.526 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.127020e-03 2.505 0 0
Separation of Sister Chromatids R-HSA-2467813 3.211277e-03 2.493 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.239607e-03 2.490 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.277652e-03 2.484 0 0
Transmission across Chemical Synapses R-HSA-112315 3.444952e-03 2.463 0 0
Mitotic Anaphase R-HSA-68882 3.579503e-03 2.446 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.670709e-03 2.435 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.120064e-03 2.385 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.371626e-03 2.359 0 0
Long-term potentiation R-HSA-9620244 4.371626e-03 2.359 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.406998e-03 2.356 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.998003e-03 2.301 0 0
Activation of TRKA receptors R-HSA-187015 5.051932e-03 2.297 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.051932e-03 2.297 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.870255e-03 2.231 0 0
Signaling by Hedgehog R-HSA-5358351 6.051552e-03 2.218 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 6.071331e-03 2.217 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.619953e-03 2.179 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.037893e-02 1.984 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.037893e-02 1.984 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.037893e-02 1.984 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.037893e-02 1.984 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.037893e-02 1.984 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.037893e-02 1.984 0 0
Striated Muscle Contraction R-HSA-390522 8.774304e-03 2.057 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.882132e-03 2.051 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.882132e-03 2.051 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.024548e-02 1.989 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.365169e-03 2.078 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.176366e-03 2.144 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.637179e-03 2.117 0 0
Hemostasis R-HSA-109582 1.048146e-02 1.980 0 0
Metabolism of proteins R-HSA-392499 1.060815e-02 1.974 0 0
Membrane Trafficking R-HSA-199991 1.081340e-02 1.966 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.097719e-02 1.960 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 1.098677e-02 1.959 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.159159e-02 1.936 1 1
Eukaryotic Translation Initiation R-HSA-72613 1.220948e-02 1.913 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.220948e-02 1.913 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.241597e-02 1.906 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.241597e-02 1.906 0 0
Generation of second messenger molecules R-HSA-202433 1.350380e-02 1.870 0 0
Neuronal System R-HSA-112316 1.415788e-02 1.849 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.427663e-02 1.845 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.495413e-02 1.825 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.677465e-02 1.775 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.715628e-02 1.766 0 0
Platelet degranulation R-HSA-114608 1.721033e-02 1.764 0 0
Influenza Infection R-HSA-168255 1.833708e-02 1.737 0 0
Prolonged ERK activation events R-HSA-169893 1.888163e-02 1.724 0 0
Peptide chain elongation R-HSA-156902 1.935548e-02 1.713 0 0
Apoptotic execution phase R-HSA-75153 1.943377e-02 1.711 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.056030e-02 1.687 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.065076e-02 1.685 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.067631e-02 1.685 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.135202e-02 1.671 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.204454e-02 1.657 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.221117e-02 1.653 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.254027e-02 1.647 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.254027e-02 1.647 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.275066e-02 1.643 0 0
Ribosome-associated quality control R-HSA-9948299 2.398702e-02 1.620 0 0
GAB1 signalosome R-HSA-180292 2.447036e-02 1.611 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.447036e-02 1.611 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.447036e-02 1.611 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.495120e-02 1.603 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.495120e-02 1.603 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.571228e-02 1.590 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.571228e-02 1.590 0 0
Eukaryotic Translation Termination R-HSA-72764 2.571228e-02 1.590 0 0
Interferon Signaling R-HSA-913531 2.673614e-02 1.573 0 0
Vesicle-mediated transport R-HSA-5653656 2.753891e-02 1.560 0 0
Negative regulation of MET activity R-HSA-6807004 2.852424e-02 1.545 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.852424e-02 1.545 0 0
Signal transduction by L1 R-HSA-445144 2.852424e-02 1.545 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.852424e-02 1.545 0 0
Glycolysis R-HSA-70171 2.972645e-02 1.527 0 0
Signaling by ROBO receptors R-HSA-376176 2.983264e-02 1.525 0 0
Selenocysteine synthesis R-HSA-2408557 3.057130e-02 1.515 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.064497e-02 1.514 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.064497e-02 1.514 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.081661e-02 1.511 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.081661e-02 1.511 0 0
Potential therapeutics for SARS R-HSA-9679191 3.228505e-02 1.491 0 0
Viral mRNA Translation R-HSA-192823 3.230327e-02 1.491 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.282624e-02 1.484 0 0
Attachment and Entry R-HSA-9694614 3.282624e-02 1.484 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.282624e-02 1.484 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.319045e-02 1.479 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.370226e-02 1.472 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.506656e-02 1.455 0 0
mTORC1-mediated signalling R-HSA-166208 3.506656e-02 1.455 0 0
Muscle contraction R-HSA-397014 3.576721e-02 1.447 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.589976e-02 1.445 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.688087e-02 1.433 0 0
Syndecan interactions R-HSA-3000170 3.736450e-02 1.428 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.783899e-02 1.422 0 0
Generic Transcription Pathway R-HSA-212436 3.801308e-02 1.420 0 0
TCR signaling R-HSA-202403 3.979791e-02 1.400 0 0
NTF3 activates NTRK3 signaling R-HSA-9034013 4.087756e-02 1.389 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.087756e-02 1.389 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.087756e-02 1.389 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.181377e-02 1.379 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.181377e-02 1.379 0 0
FCERI mediated MAPK activation R-HSA-2871796 4.181377e-02 1.379 0 0
Formation of the nephric duct R-HSA-9830364 4.212756e-02 1.375 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.458991e-02 1.351 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.458991e-02 1.351 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 4.710253e-02 1.327 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.710433e-02 1.327 0 0
Glucose metabolism R-HSA-70326 4.931750e-02 1.307 0 0
rRNA processing R-HSA-72312 4.979381e-02 1.303 0 0
PLC-gamma1 signalling R-HSA-167021 5.083468e-02 1.294 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.083468e-02 1.294 0 0
Axonal growth stimulation R-HSA-209563 5.083468e-02 1.294 0 0
MET interacts with TNS proteins R-HSA-8875513 5.083468e-02 1.294 0 0
Invadopodia formation R-HSA-8941237 5.083468e-02 1.294 0 0
MET activates PTPN11 R-HSA-8865999 5.083468e-02 1.294 0 0
Signalling to STAT3 R-HSA-198745 5.083468e-02 1.294 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 6.068904e-02 1.217 0 0
IRS activation R-HSA-74713 7.044170e-02 1.152 0 0
NGF-independant TRKA activation R-HSA-187024 8.009369e-02 1.096 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.009369e-02 1.096 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 8.009369e-02 1.096 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 8.009369e-02 1.096 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 8.009369e-02 1.096 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 8.964605e-02 1.047 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 9.909980e-02 1.004 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 9.909980e-02 1.004 0 0
Downstream signal transduction R-HSA-186763 5.765633e-02 1.239 0 0
Neutrophil degranulation R-HSA-6798695 6.430788e-02 1.192 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.317887e-02 1.080 0 0
Parasite infection R-HSA-9664407 8.317887e-02 1.080 0 0
Leishmania phagocytosis R-HSA-9664417 8.317887e-02 1.080 0 0
PTK6 Expression R-HSA-8849473 9.909980e-02 1.004 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.660582e-02 1.015 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 8.009369e-02 1.096 0 0
MET Receptor Activation R-HSA-6806942 8.964605e-02 1.047 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 9.021277e-02 1.045 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.765633e-02 1.239 0 0
Signalling to ERKs R-HSA-187687 7.186431e-02 1.143 0 0
MET activates STAT3 R-HSA-8875791 5.083468e-02 1.294 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 9.909980e-02 1.004 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.228405e-02 1.282 0 0
HSF1 activation R-HSA-3371511 7.482963e-02 1.126 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.393166e-02 1.027 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.087484e-02 1.092 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.321112e-02 1.199 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 7.044170e-02 1.152 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.425695e-02 1.074 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 5.765633e-02 1.239 0 0
Parasitic Infection Pathways R-HSA-9824443 9.677868e-02 1.014 0 0
Leishmania infection R-HSA-9658195 9.677868e-02 1.014 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 6.068904e-02 1.217 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 8.009369e-02 1.096 0 0
Integrin signaling R-HSA-354192 6.321112e-02 1.199 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 8.009369e-02 1.096 0 0
Nef and signal transduction R-HSA-164944 8.964605e-02 1.047 0 0
CHL1 interactions R-HSA-447041 9.909980e-02 1.004 0 0
Attenuation phase R-HSA-3371568 8.706553e-02 1.060 0 0
MTOR signalling R-HSA-165159 9.660582e-02 1.015 0 0
G0 and Early G1 R-HSA-1538133 6.041153e-02 1.219 0 0
Interleukin-37 signaling R-HSA-9008059 5.494676e-02 1.260 0 0
G1/S-Specific Transcription R-HSA-69205 7.482963e-02 1.126 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.984963e-02 1.001 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.893869e-02 1.162 0 0
RNA Polymerase II Transcription R-HSA-73857 8.433407e-02 1.074 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.402875e-02 1.027 0 0
Programmed Cell Death R-HSA-5357801 8.797692e-02 1.056 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.395254e-02 1.076 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.002119e-01 0.999 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.022879e-01 0.990 0 0
Proteasome assembly R-HSA-9907900 1.031236e-01 0.987 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.064269e-01 0.973 0 0
Post-translational protein phosphorylation R-HSA-8957275 1.065737e-01 0.972 0 0
Death Receptor Signaling R-HSA-73887 1.067782e-01 0.972 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 1.084560e-01 0.965 0 0
MET receptor recycling R-HSA-8875656 1.084560e-01 0.965 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.084560e-01 0.965 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.087427e-01 0.964 0 0
Innate Immune System R-HSA-168249 1.123174e-01 0.950 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.135349e-01 0.945 0 0
Cellular response to starvation R-HSA-9711097 1.135349e-01 0.945 0 0
ARMS-mediated activation R-HSA-170984 1.177155e-01 0.929 0 0
p75NTR regulates axonogenesis R-HSA-193697 1.177155e-01 0.929 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.177155e-01 0.929 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.177155e-01 0.929 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.177155e-01 0.929 0 0
Degradation of CDH1 R-HSA-9766229 1.199134e-01 0.921 0 0
Apoptosis R-HSA-109581 1.204764e-01 0.919 0 0
RSV-host interactions R-HSA-9833110 1.221087e-01 0.913 0 0
Azathioprine ADME R-HSA-9748787 1.233489e-01 0.909 0 0
Selenoamino acid metabolism R-HSA-2408522 1.240148e-01 0.907 0 0
HSF1-dependent transactivation R-HSA-3371571 1.268082e-01 0.897 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.268795e-01 0.897 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.268795e-01 0.897 0 0
Regulation of CDH11 function R-HSA-9762292 1.268795e-01 0.897 0 0
PI3K/AKT activation R-HSA-198203 1.268795e-01 0.897 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.268795e-01 0.897 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.268795e-01 0.897 0 0
Signal attenuation R-HSA-74749 1.268795e-01 0.897 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.302904e-01 0.885 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.302904e-01 0.885 0 0
Gene expression (Transcription) R-HSA-74160 1.343634e-01 0.872 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.359488e-01 0.867 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.359488e-01 0.867 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.359488e-01 0.867 0 0
vRNP Assembly R-HSA-192905 1.359488e-01 0.867 0 0
Interleukin-2 signaling R-HSA-9020558 1.359488e-01 0.867 0 0
Translation initiation complex formation R-HSA-72649 1.373201e-01 0.862 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.444317e-01 0.840 0 0
Signaling by EGFR R-HSA-177929 1.444317e-01 0.840 0 0
NRAGE signals death through JNK R-HSA-193648 1.444317e-01 0.840 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 1.444317e-01 0.840 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.449245e-01 0.839 0 0
Regulation of CDH1 Function R-HSA-9764561 1.480161e-01 0.830 0 0
Dectin-2 family R-HSA-5621480 1.480161e-01 0.830 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 1.480497e-01 0.830 0 0
SARS-CoV Infections R-HSA-9679506 1.499402e-01 0.824 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.516187e-01 0.819 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 1.516187e-01 0.819 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 1.529469e-01 0.815 0 0
MET activates RAS signaling R-HSA-8851805 1.538075e-01 0.813 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.538075e-01 0.813 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 1.538075e-01 0.813 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 1.538075e-01 0.813 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.538075e-01 0.813 0 0
Leading Strand Synthesis R-HSA-69109 1.538075e-01 0.813 0 0
Polymerase switching R-HSA-69091 1.538075e-01 0.813 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.538075e-01 0.813 0 0
Extracellular matrix organization R-HSA-1474244 1.624159e-01 0.789 1 0
Frs2-mediated activation R-HSA-170968 1.625988e-01 0.789 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 1.625988e-01 0.789 0 0
Signaling by PDGF R-HSA-186797 1.661948e-01 0.779 0 0
Mitochondrial protein import R-HSA-1268020 1.661948e-01 0.779 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.661948e-01 0.779 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.712992e-01 0.766 0 0
Removal of the Flap Intermediate R-HSA-69166 1.712992e-01 0.766 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.712992e-01 0.766 0 0
Physiological factors R-HSA-5578768 1.712992e-01 0.766 0 0
Developmental Cell Lineages R-HSA-9734767 1.752723e-01 0.756 0 0
Host Interactions of HIV factors R-HSA-162909 1.755882e-01 0.756 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.772813e-01 0.751 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.799098e-01 0.745 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.799098e-01 0.745 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.799098e-01 0.745 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.799098e-01 0.745 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.799098e-01 0.745 0 0
Translesion synthesis by REV1 R-HSA-110312 1.799098e-01 0.745 0 0
DCC mediated attractive signaling R-HSA-418885 1.799098e-01 0.745 0 0
G1/S Transition R-HSA-69206 1.807429e-01 0.743 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 1.833356e-01 0.737 0 0
Kidney development R-HSA-9830369 1.847355e-01 0.733 0 0
Metabolism of RNA R-HSA-8953854 1.848315e-01 0.733 0 0
Translesion synthesis by POLI R-HSA-5656121 1.884315e-01 0.725 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.884315e-01 0.725 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.884315e-01 0.725 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.898273e-01 0.722 0 0
Translesion synthesis by POLK R-HSA-5655862 1.968651e-01 0.706 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 1.968651e-01 0.706 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 1.968651e-01 0.706 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 1.968651e-01 0.706 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 1.968651e-01 0.706 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.968651e-01 0.706 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.052116e-01 0.688 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.052116e-01 0.688 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 2.052116e-01 0.688 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.052116e-01 0.688 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.052116e-01 0.688 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.052116e-01 0.688 0 0
Signaling by Hippo R-HSA-2028269 2.052116e-01 0.688 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.073455e-01 0.683 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.134719e-01 0.671 0 0
Ephrin signaling R-HSA-3928664 2.134719e-01 0.671 0 0
Mismatch Repair R-HSA-5358508 2.134719e-01 0.671 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.149487e-01 0.668 0 0
Interleukin-12 signaling R-HSA-9020591 2.187602e-01 0.660 0 0
Translesion Synthesis by POLH R-HSA-110320 2.216468e-01 0.654 0 0
Regulation of signaling by CBL R-HSA-912631 2.216468e-01 0.654 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.216468e-01 0.654 0 0
The NLRP3 inflammasome R-HSA-844456 2.216468e-01 0.654 0 0
G alpha (12/13) signalling events R-HSA-416482 2.264003e-01 0.645 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.268688e-01 0.644 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 2.297373e-01 0.639 0 0
Protein hydroxylation R-HSA-9629569 2.297373e-01 0.639 0 0
Signaling by MET R-HSA-6806834 2.340598e-01 0.631 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.342463e-01 0.630 0 0
Signaling by Interleukins R-HSA-449147 2.343749e-01 0.630 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.369975e-01 0.625 0 0
Lagging Strand Synthesis R-HSA-69186 2.377442e-01 0.624 0 0
Signalling to RAS R-HSA-167044 2.377442e-01 0.624 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.452846e-01 0.610 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.456683e-01 0.610 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.456683e-01 0.610 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.456683e-01 0.610 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.456683e-01 0.610 0 0
Ribavirin ADME R-HSA-9755088 2.456683e-01 0.610 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.494208e-01 0.603 0 0
Signaling by NTRKs R-HSA-166520 2.508351e-01 0.601 0 0
FGFR2 alternative splicing R-HSA-6803529 2.535105e-01 0.596 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.535105e-01 0.596 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.571147e-01 0.590 0 0
Bacterial Infection Pathways R-HSA-9824439 2.597804e-01 0.585 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.605444e-01 0.584 0 0
Formation of the ureteric bud R-HSA-9830674 2.612717e-01 0.583 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.612717e-01 0.583 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.612717e-01 0.583 0 0
Interleukin-1 family signaling R-HSA-446652 2.619912e-01 0.582 0 0
Interleukin-12 family signaling R-HSA-447115 2.648129e-01 0.577 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 2.689527e-01 0.570 0 0
Deadenylation of mRNA R-HSA-429947 2.689527e-01 0.570 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.689527e-01 0.570 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.689527e-01 0.570 0 0
Interleukin-6 family signaling R-HSA-6783589 2.689527e-01 0.570 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.689527e-01 0.570 0 0
Neurodegenerative Diseases R-HSA-8863678 2.689527e-01 0.570 0 0
Downstream TCR signaling R-HSA-202424 2.763604e-01 0.559 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.765542e-01 0.558 0 0
Tight junction interactions R-HSA-420029 2.765542e-01 0.558 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 2.765542e-01 0.558 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.765542e-01 0.558 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 2.765542e-01 0.558 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.802080e-01 0.553 0 0
MET activates PTK2 signaling R-HSA-8874081 2.840772e-01 0.547 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.840772e-01 0.547 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.840772e-01 0.547 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 2.915225e-01 0.535 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 2.915225e-01 0.535 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.915225e-01 0.535 0 0
Cristae formation R-HSA-8949613 2.915225e-01 0.535 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.915225e-01 0.535 0 0
FCGR activation R-HSA-2029481 2.917407e-01 0.535 0 0
Mitochondrial protein degradation R-HSA-9837999 2.955803e-01 0.529 0 0
Insulin receptor recycling R-HSA-77387 2.988907e-01 0.524 0 0
Inflammasomes R-HSA-622312 2.988907e-01 0.524 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.061828e-01 0.514 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.061828e-01 0.514 0 0
Signaling by Erythropoietin R-HSA-9006335 3.061828e-01 0.514 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 3.133995e-01 0.504 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.184846e-01 0.497 0 0
EGFR downregulation R-HSA-182971 3.205415e-01 0.494 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.205415e-01 0.494 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.205415e-01 0.494 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 3.241658e-01 0.489 0 0
Leishmania parasite growth and survival R-HSA-9664433 3.241658e-01 0.489 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.261636e-01 0.487 0 0
DNA strand elongation R-HSA-69190 3.276097e-01 0.485 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.276097e-01 0.485 0 0
HS-GAG degradation R-HSA-2024096 3.276097e-01 0.485 0 0
Translation R-HSA-72766 3.298844e-01 0.482 0 0
PI Metabolism R-HSA-1483255 3.299649e-01 0.482 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.346049e-01 0.475 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.346049e-01 0.475 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.375498e-01 0.472 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.415276e-01 0.467 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.415276e-01 0.467 0 0
Heme degradation R-HSA-189483 3.415276e-01 0.467 0 0
Nucleotide Excision Repair R-HSA-5696398 3.451092e-01 0.462 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 3.483788e-01 0.458 0 0
Dual Incision in GG-NER R-HSA-5696400 3.483788e-01 0.458 0 0
Nuclear import of Rev protein R-HSA-180746 3.483788e-01 0.458 0 0
eNOS activation R-HSA-203615 3.483788e-01 0.458 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.483788e-01 0.458 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.483788e-01 0.458 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.483788e-01 0.458 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.483788e-01 0.458 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.488786e-01 0.457 0 0
Synthesis of DNA R-HSA-69239 3.526408e-01 0.453 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.526408e-01 0.453 0 0
Signaling by ALK in cancer R-HSA-9700206 3.526408e-01 0.453 0 0
Cellular response to chemical stress R-HSA-9711123 3.538150e-01 0.451 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.551591e-01 0.450 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.551591e-01 0.450 0 0
Regulation of Apoptosis R-HSA-169911 3.551591e-01 0.450 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.563956e-01 0.448 0 0
RET signaling R-HSA-8853659 3.618693e-01 0.441 0 0
HS-GAG biosynthesis R-HSA-2022928 3.618693e-01 0.441 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.618693e-01 0.441 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.618693e-01 0.441 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 3.685100e-01 0.434 0 0
Degradation of DVL R-HSA-4641258 3.685100e-01 0.434 0 0
Degradation of AXIN R-HSA-4641257 3.685100e-01 0.434 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.685100e-01 0.434 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.685100e-01 0.434 0 0
MET promotes cell motility R-HSA-8875878 3.750821e-01 0.426 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.750821e-01 0.426 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.750821e-01 0.426 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.750821e-01 0.426 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 3.779758e-01 0.423 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 3.815861e-01 0.418 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.815861e-01 0.418 0 0
Stabilization of p53 R-HSA-69541 3.815861e-01 0.418 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.836249e-01 0.416 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.880229e-01 0.411 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.880229e-01 0.411 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.880229e-01 0.411 0 0
Glycogen metabolism R-HSA-8982491 3.880229e-01 0.411 0 0
Interleukin-2 family signaling R-HSA-451927 3.880229e-01 0.411 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.943930e-01 0.404 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.943930e-01 0.404 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.943930e-01 0.404 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.943930e-01 0.404 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 3.943930e-01 0.404 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 3.943930e-01 0.404 0 0
FLT3 Signaling R-HSA-9607240 3.943930e-01 0.404 0 0
Rab regulation of trafficking R-HSA-9007101 3.971391e-01 0.401 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.006973e-01 0.397 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.006973e-01 0.397 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.006973e-01 0.397 0 0
Intra-Golgi traffic R-HSA-6811438 4.006973e-01 0.397 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.006973e-01 0.397 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.006973e-01 0.397 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.069363e-01 0.390 0 0
Cellular response to heat stress R-HSA-3371556 4.116669e-01 0.385 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 4.116669e-01 0.385 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.131107e-01 0.384 0 0
mRNA Splicing R-HSA-72172 4.143578e-01 0.383 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.192213e-01 0.378 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.192213e-01 0.378 0 0
Netrin-1 signaling R-HSA-373752 4.192213e-01 0.378 0 0
Formation of the cornified envelope R-HSA-6809371 4.224500e-01 0.374 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.252686e-01 0.371 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 4.252686e-01 0.371 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.252686e-01 0.371 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.252686e-01 0.371 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.252686e-01 0.371 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.252686e-01 0.371 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.252686e-01 0.371 0 0
Somitogenesis R-HSA-9824272 4.252686e-01 0.371 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.312532e-01 0.365 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.312532e-01 0.365 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.312532e-01 0.365 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.312532e-01 0.365 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.312532e-01 0.365 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.312532e-01 0.365 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.312532e-01 0.365 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.371760e-01 0.359 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.401945e-01 0.356 0 0
DNA Damage Bypass R-HSA-73893 4.488382e-01 0.348 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.488382e-01 0.348 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.488382e-01 0.348 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.545788e-01 0.342 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.602601e-01 0.337 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.602601e-01 0.337 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.602601e-01 0.337 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.658825e-01 0.332 0 0
Orc1 removal from chromatin R-HSA-68949 4.658825e-01 0.332 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.658825e-01 0.332 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.658825e-01 0.332 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.714467e-01 0.327 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.714467e-01 0.327 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.714467e-01 0.327 0 0
Nucleotide biosynthesis R-HSA-8956320 4.714467e-01 0.327 0 0
HIV Infection R-HSA-162906 4.768836e-01 0.322 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.769532e-01 0.322 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.769532e-01 0.322 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.824028e-01 0.317 0 0
Signaling by NOTCH3 R-HSA-9012852 4.824028e-01 0.317 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.877959e-01 0.312 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.877959e-01 0.312 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.877959e-01 0.312 0 0
TNF signaling R-HSA-75893 4.877959e-01 0.312 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.931331e-01 0.307 0 0
Dual incision in TC-NER R-HSA-6782135 4.984151e-01 0.302 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 5.036423e-01 0.298 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.036423e-01 0.298 0 0
Extension of Telomeres R-HSA-180786 5.036423e-01 0.298 0 0
Metabolism of polyamines R-HSA-351202 5.088154e-01 0.293 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.139348e-01 0.289 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.139348e-01 0.289 0 0
Collagen degradation R-HSA-1442490 5.139348e-01 0.289 0 0
S Phase R-HSA-69242 5.177432e-01 0.286 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.190013e-01 0.285 0 0
tRNA processing in the nucleus R-HSA-6784531 5.190013e-01 0.285 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.190013e-01 0.285 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.240152e-01 0.281 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.240152e-01 0.281 0 0
CD22 mediated BCR regulation R-HSA-5690714 5.289772e-01 0.277 0 0
Insulin receptor signalling cascade R-HSA-74751 5.289772e-01 0.277 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.289772e-01 0.277 0 0
Protein localization R-HSA-9609507 5.336444e-01 0.273 0 0
Cellular response to hypoxia R-HSA-1234174 5.338877e-01 0.273 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.435567e-01 0.265 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.483161e-01 0.261 0 0
Regulated Necrosis R-HSA-5218859 5.483161e-01 0.261 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.576875e-01 0.254 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.576875e-01 0.254 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.576875e-01 0.254 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.623005e-01 0.250 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.623005e-01 0.250 0 0
Retinoid metabolism and transport R-HSA-975634 5.623005e-01 0.250 0 0
Metabolism of cofactors R-HSA-8978934 5.623005e-01 0.250 0 0
Hedgehog 'on' state R-HSA-5632684 5.623005e-01 0.250 0 0
Metabolism of porphyrins R-HSA-189445 5.623005e-01 0.250 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 5.668656e-01 0.247 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.668656e-01 0.247 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.668656e-01 0.247 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.713834e-01 0.243 0 0
Signaling by NOTCH4 R-HSA-9013694 5.758543e-01 0.240 0 0
ROS and RNS production in phagocytes R-HSA-1222556 5.758543e-01 0.240 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.802789e-01 0.236 0 0
UCH proteinases R-HSA-5689603 5.846576e-01 0.233 0 0
ABC transporter disorders R-HSA-5619084 5.932793e-01 0.227 0 0
PCP/CE pathway R-HSA-4086400 5.932793e-01 0.227 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 5.975232e-01 0.224 0 0
Sensory processing of sound R-HSA-9659379 5.975232e-01 0.224 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.975232e-01 0.224 0 0
Signaling by FGFR2 R-HSA-5654738 6.017230e-01 0.221 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.021029e-01 0.220 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.052819e-01 0.218 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 6.058793e-01 0.218 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.140630e-01 0.212 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.140630e-01 0.212 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.220777e-01 0.206 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.220777e-01 0.206 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.260228e-01 0.203 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 6.299269e-01 0.201 0 0
ER-Phagosome pathway R-HSA-1236974 6.413979e-01 0.193 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.476830e-01 0.189 0 0
Signaling by Insulin receptor R-HSA-74752 6.561446e-01 0.183 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 6.737329e-01 0.172 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.771418e-01 0.169 0 0
Signaling by FGFR R-HSA-190236 6.805152e-01 0.167 0 0
Keratinization R-HSA-6805567 6.844019e-01 0.165 0 0
ABC-family proteins mediated transport R-HSA-382556 6.871573e-01 0.163 0 0
Interleukin-1 signaling R-HSA-9020702 6.904267e-01 0.161 0 0
Drug ADME R-HSA-9748784 7.114860e-01 0.148 0 0
Neddylation R-HSA-8951664 7.179477e-01 0.144 0 0
Inositol phosphate metabolism R-HSA-1483249 7.271079e-01 0.138 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 7.345897e-01 0.134 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.383478e-01 0.132 0 0
Mitochondrial biogenesis R-HSA-1592230 7.464746e-01 0.127 0 0
Metabolism of nucleotides R-HSA-15869 7.484636e-01 0.126 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.517526e-01 0.124 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.569214e-01 0.121 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.690130e-01 0.114 0 0
Cardiac conduction R-HSA-5576891 7.857625e-01 0.105 0 0
Circadian clock R-HSA-9909396 7.880065e-01 0.103 0 0
Degradation of the extracellular matrix R-HSA-1474228 7.880065e-01 0.103 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.988805e-01 0.098 0 0
Metabolism of amino acids and derivatives R-HSA-71291 7.999984e-01 0.097 0 0
PTEN Regulation R-HSA-6807070 8.051368e-01 0.094 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.131786e-01 0.090 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.170750e-01 0.088 0 0
Visual phototransduction R-HSA-2187338 8.227685e-01 0.085 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.246269e-01 0.084 0 0
Gastrulation R-HSA-9758941 8.264659e-01 0.083 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 8.282858e-01 0.082 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.300867e-01 0.081 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.318688e-01 0.080 0 0
HIV Life Cycle R-HSA-162587 8.405046e-01 0.075 0 0
Phospholipid metabolism R-HSA-1483257 8.424949e-01 0.074 0 0
SLC transporter disorders R-HSA-5619102 8.564752e-01 0.067 0 0
tRNA processing R-HSA-72306 8.624089e-01 0.064 0 0
Diseases of glycosylation R-HSA-3781865 8.813205e-01 0.055 0 0
Toll-like Receptor Cascades R-HSA-168898 8.897834e-01 0.051 0 0
Glycosaminoglycan metabolism R-HSA-1630316 8.920892e-01 0.050 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.114963e-01 0.040 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.254691e-01 0.034 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.329868e-01 0.030 0 0
G alpha (q) signalling events R-HSA-416476 9.496806e-01 0.022 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.566355e-01 0.019 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.584408e-01 0.018 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.638244e-01 0.016 0 0
Metabolism of steroids R-HSA-8957322 9.734250e-01 0.012 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.778322e-01 0.010 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.879480e-01 0.005 0 0
GPCR downstream signalling R-HSA-388396 9.903795e-01 0.004 0 0
Diseases of metabolism R-HSA-5668914 9.912627e-01 0.004 0 0
Signaling by GPCR R-HSA-372790 9.953469e-01 0.002 0 0
Biological oxidations R-HSA-211859 9.968913e-01 0.001 0 0
Metabolism R-HSA-1430728 9.997116e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.997505e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999823e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999889e-01 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways