STLK3

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Y Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Log-Odds: Y Sites / Y Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	S939	Sugiyama	POTEF A26C1B	VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
O95747	S339	Sugiyama	OXSR1 KIAA1101 OSR1	RRVPGssGRLHKtEDGGWEWsDDEFDEEsEEGKAAIsQLRs
O95863	T203	PSP	SNAI1 SNAH	GTCGKAFSRPWLLQGHVRTHtGEKPFSCPHCSRAFADRSNL
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00338	Y239	Sugiyama	LDHA PIG19	GtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVADL
P02786	S151	Sugiyama	TFRC	LsEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVEN
P02786	T336	Sugiyama	TFRC	FNHTQFPPSRSSGLPNIPVQtISRAAAEKLFGNMEGDCPSD
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04406	Y314	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	tFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsK
P04406	Y320	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE_____
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P06733	S353	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMVsHRs
P06733	Y270	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P06733	Y280	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	DFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDD
P06733	Y44	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P06744	T218	Sugiyama	GPI	QLNPESSLFIIASKTFTTQEtITNAEtAKEWFLQAAKDPSA
P07195	T18	Sugiyama	LDHB	___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07237	Y94	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07814	Y827	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	EIGQNIssNssAsILESKsLyDEVAAQGEVVRKLKAEKSPK
P07900	Y309	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900	Y313	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238	Y301	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238	Y305	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238	Y472	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	sELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEsKE
P09104	Y44	Sugiyama	ENO2	LyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKGVLK
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P10809	Y243	Sugiyama	HSPD1 HSP60	yIsPyFINtsKGQKCEFQDAyVLLsEKKIssIQsIVPALEI
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P13929	Y44	Sugiyama	ENO3	LHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKGVLK
P14618	T50	Sugiyama	PKM OIP3 PK2 PK3 PKM2	MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066	T228	Sugiyama	HSPA6 HSP70B'	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P22059	S190	Sugiyama	OSBP OSBP1	QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059	S193	Sugiyama	OSBP OSBP1	VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P23528	Y140	Sugiyama	CFL1 CFL	SKDAIKKKLtGIKHELQANCyEEVKDRCTLAEKLGGsAVIs
P24752	T220	Sugiyama	ACAT1 ACAT MAT	TAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPVtV
P25786	T11	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	__________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P29401	Y481	Sugiyama	TKT	AANTKGICFIRTsRPENAIIyNNNEDFQVGQAKVVLKSKDD
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931	T228	Sugiyama	HSPA1L	DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P36578	Y52	Sugiyama	RPL4 RPL1	IRPDIVNFVHTNLRKNNRQPyAVsELAGHQtsAEsWGtGRA
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646	T120	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646	T398	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P38646	Y118	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39019	Y48	Sugiyama	RPS19	LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741	T228	Sugiyama	HSPA7 HSP70B	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P49327	S286	Sugiyama	FASN FAS	GDIQEQLIRSLyQsAGVAPEsFEyIEAHGtGTKVGDPQELN
P49327	Y277	Sugiyama	FASN FAS	KEQGVtFPsGDIQEQLIRSLyQsAGVAPEsFEyIEAHGtGT
P49773	T17	Sugiyama	HINT1 HINT PKCI1 PRKCNH1	____MADEIAKAQVARPGGDtIFGKIIRKEIPAKIIFEDDR
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P55011	T203	PSP	SLC12A2 NKCC1	SSLHSGGGGGSGHHQHYYYDtHTNtYYLRtFGHNtMDAVPR
P55011	T207	PSP	SLC12A2 NKCC1	SGGGGGSGHHQHYYYDtHTNtYYLRtFGHNtMDAVPRIDHy
P55011	T212	PSP	SLC12A2 NKCC1	GSGHHQHYYYDtHTNtYYLRtFGHNtMDAVPRIDHyRHtAA
P55017	T46	PSP	SLC12A3 NCC TSC	LSSDEPSPPAAYDSSHPSHLtHSStFCMRtFGYNtIDVVPT
P55017	T55	SIGNOR\|PSP	SLC12A3 NCC TSC	AAYDSSHPSHLtHSStFCMRtFGYNtIDVVPTYEHYANsTQ
P55017	T60	PSP	SLC12A3 NCC TSC	SHPSHLtHSStFCMRtFGYNtIDVVPTYEHYANsTQPGEPR
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174	T90	Sugiyama	TPI1 TPI	VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S239	Sugiyama	ACTB	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62736	S241	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62917	T135	Sugiyama	RPL8	CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62937	Y79	Sugiyama	PPIA CYPA	GFMCQGGDFtRHNGTGGKsIyGEKFEDENFILKHtGPGILs
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63220	Y53	Sugiyama	RPS21	QMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRLA
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S239	Sugiyama	ACTG1 ACTG	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267	S240	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032	S241	Sugiyama	ACTC1 ACTC	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	S241	Sugiyama	ACTA1 ACTA	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
Q01105	Y146	Sugiyama	SET	tEFEDIKsGyRIDFyFDENPyFENKVLSKEFHLNEsGDPss
Q12792	Y309	Sugiyama	TWF1 PTK9	MDVIRKIEIDNGDELtADFLyEEVHPKQHAHKQSFAKPKGP
Q13561	T315	Sugiyama	DCTN2 DCTN50	KHKASVEDADTQSKVHQLyEtIQRWsPIASTLPELVQRLVT
Q13621	S130	SIGNOR	SLC12A1 NKCC2	PKIEYYRNtGsIsGPKVNRPsLLEIHEQLAKNVAVTPSSAD
Q13621	S91	SIGNOR	SLC12A1 NKCC2	DNFLQSGETAKTDASFHAYDsHTNtYYLQtFGHNtMDAVPK
Q13621	T100	SIGNOR\|PSP	SLC12A1 NKCC2	AKTDASFHAYDsHTNtYYLQtFGHNtMDAVPKIEYYRNtGs
Q13621	T105	SIGNOR\|PSP	SLC12A1 NKCC2	SFHAYDsHTNtYYLQtFGHNtMDAVPKIEYYRNtGsIsGPK
Q13621	T95	SIGNOR\|PSP	SLC12A1 NKCC2	QSGETAKTDASFHAYDsHTNtYYLQtFGHNtMDAVPKIEYY
Q562R1	S240	Sugiyama	ACTBL2	VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q6S8J3	S939	Sugiyama	POTEE A26C1A POTE2	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q86W56	Y832	Sugiyama	PARG	DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q96AY3	Y201	Sugiyama	FKBP10 FKBP65 PSEC0056	YNGTLLDGTSFDTSYSKGGtyDtyVGsGWLIKGMDQGLLGM
Q96AY3	Y204	Sugiyama	FKBP10 FKBP65 PSEC0056	TLLDGTSFDTSYSKGGtyDtyVGsGWLIKGMDQGLLGMCPG
Q9BYX7	S239	Sugiyama	POTEKP ACTBL3 FKSG30	VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9H4A3	T48	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GSssDssVGEKLGAAAADAVtGRtEEyRRRRHtMDKDSRGA
Q9H4A3	T51	Sugiyama	WNK1 HSN2 KDP KIAA0344 PRKWNK1	sDssVGEKLGAAAADAVtGRtEEyRRRRHtMDKDSRGAAAt
Q9UBR2	S78	Sugiyama	CTSZ	SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST
Q9UHW9	S96	SIGNOR\|PSP	SLC12A6 KCC3	DPPSDRTSHPQDVIEDLsQNsItGEHSQLLDDGHKKARNAY
Q9UHW9	T1048	PSP	SLC12A6 KCC3	tsIGsDEDEEtETYQEKVHMtWTKDKYMASRGQKAKsMEGF
Q9Y3F4	Y280	Sugiyama	STRAP MAWD UNRIP	syKGHFGPIHCVRFSPDGELyAsGSEDGTLRLWQTVVGKty
Q9Y6R1	S65	PSP	SLC4A4 NBC NBC1 NBCE1	HKRKtGHKEKKEKERIsENysDKsDIENADEssssILKPLI

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Cation-coupled Chloride cotransporters	R-HSA-426117	1.354191e-07	6.868
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.848173e-07	6.545
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.722698e-07	6.012
Apoptotic execution phase	R-HSA-75153	1.298028e-06	5.887
RAF activation	R-HSA-5673000	4.415545e-06	5.355
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	4.900516e-06	5.310
Interleukin-12 family signaling	R-HSA-447115	4.773244e-06	5.321
Interleukin-12 signaling	R-HSA-9020591	4.797300e-06	5.319
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.557883e-05	4.807
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.793930e-05	4.746
Mitotic Prometaphase	R-HSA-68877	2.245818e-05	4.649
Signaling by RAS mutants	R-HSA-6802949	4.528349e-05	4.344
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	4.528349e-05	4.344
Signaling downstream of RAS mutants	R-HSA-9649948	4.528349e-05	4.344
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	4.528349e-05	4.344
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.054443e-05	4.218
Separation of Sister Chromatids	R-HSA-2467813	7.387378e-05	4.132
Post NMDA receptor activation events	R-HSA-438064	8.484711e-05	4.071
Signaling by RAF1 mutants	R-HSA-9656223	1.144461e-04	3.941
Negative regulation of MAPK pathway	R-HSA-5675221	1.144461e-04	3.941
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.144461e-04	3.941
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.023310e-04	3.694
Cell Cycle, Mitotic	R-HSA-69278	2.242547e-04	3.649
Transport of connexons to the plasma membrane	R-HSA-190872	2.560991e-04	3.592
Recycling pathway of L1	R-HSA-437239	2.665467e-04	3.574
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.318445e-04	3.479
MAPK family signaling cascades	R-HSA-5683057	3.562307e-04	3.448
Mitotic G2-G2/M phases	R-HSA-453274	3.666300e-04	3.436
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.969532e-04	3.401
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.020342e-04	3.396
Cell Cycle	R-HSA-1640170	4.149992e-04	3.382
Aggrephagy	R-HSA-9646399	4.471922e-04	3.350
Cytokine Signaling in Immune system	R-HSA-1280215	4.398442e-04	3.357
Interleukin-37 signaling	R-HSA-9008059	4.648406e-04	3.333
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	4.965829e-04	3.304
SOS-mediated signalling	R-HSA-112412	5.850758e-04	3.233
Cell-extracellular matrix interactions	R-HSA-446353	8.037541e-04	3.095
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	8.320150e-04	3.080
Oncogenic MAPK signaling	R-HSA-6802957	8.781669e-04	3.056
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.015415e-03	2.993
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.144590e-03	2.941
Selective autophagy	R-HSA-9663891	1.224670e-03	2.912
Signaling by Interleukins	R-HSA-449147	1.371673e-03	2.863
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.472641e-03	2.832
M Phase	R-HSA-68886	1.437303e-03	2.842
RAF/MAP kinase cascade	R-HSA-5673001	1.585546e-03	2.800
Mitotic Anaphase	R-HSA-68882	1.669412e-03	2.777
Nuclear Receptor transcription pathway	R-HSA-383280	1.677050e-03	2.775
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.749357e-03	2.757
MAPK1/MAPK3 signaling	R-HSA-5684996	2.095185e-03	2.679
G2/M Transition	R-HSA-69275	2.120161e-03	2.674
Nephrin family interactions	R-HSA-373753	2.646382e-03	2.577
MAP2K and MAPK activation	R-HSA-5674135	2.674764e-03	2.573
Signal Transduction	R-HSA-162582	2.734599e-03	2.563
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.880671e-03	2.541
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.151695e-03	2.501
Amplification of signal from the kinetochores	R-HSA-141424	3.151695e-03	2.501
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	3.662182e-03	2.436
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.489334e-03	2.457
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	3.662182e-03	2.436
Signaling by PDGFR in disease	R-HSA-9671555	3.662182e-03	2.436
Apoptosis	R-HSA-109581	3.600192e-03	2.444
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	3.715456e-03	2.430
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	3.917087e-03	2.407
Notch-HLH transcription pathway	R-HSA-350054	4.263000e-03	2.370
Kinesins	R-HSA-983189	4.405550e-03	2.356
Gap junction assembly	R-HSA-190861	4.717495e-03	2.326
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	5.215344e-03	2.283
Neurodegenerative Diseases	R-HSA-8863678	5.669950e-03	2.246
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	5.669950e-03	2.246
Signaling by PTK6	R-HSA-8848021	5.660592e-03	2.247
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.660592e-03	2.247
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	5.871431e-03	2.231
Gap junction trafficking and regulation	R-HSA-157858	6.007127e-03	2.221
PKR-mediated signaling	R-HSA-9833482	6.350748e-03	2.197
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	7.007444e-03	2.154
Macroautophagy	R-HSA-1632852	7.136838e-03	2.146
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	7.007444e-03	2.154
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	8.350549e-03	2.078
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	8.359513e-03	2.078
Cell-Cell communication	R-HSA-1500931	8.541115e-03	2.068
Signaling by RAS GAP mutants	R-HSA-9753510	9.985048e-03	2.001
Mitotic Spindle Checkpoint	R-HSA-69618	9.617795e-03	2.017
Signaling by Hippo	R-HSA-2028269	9.686778e-03	2.014
Calcineurin activates NFAT	R-HSA-2025928	1.056257e-02	1.976
Signaling by EGFR	R-HSA-177929	1.087569e-02	1.964
Programmed Cell Death	R-HSA-5357801	1.141633e-02	1.942
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.180194e-02	1.928
Germ layer formation at gastrulation	R-HSA-9754189	1.295545e-02	1.888
EGFR Transactivation by Gastrin	R-HSA-2179392	1.307080e-02	1.884
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.307080e-02	1.884
Signaling by Leptin	R-HSA-2586552	1.307080e-02	1.884
Downstream signal transduction	R-HSA-186763	1.313940e-02	1.881
Signaling by ERBB2	R-HSA-1227986	1.469114e-02	1.833
Autophagy	R-HSA-9612973	1.483781e-02	1.829
Gap junction trafficking	R-HSA-190828	1.404186e-02	1.853
MET activates STAT3	R-HSA-8875791	1.522658e-02	1.817
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.611330e-02	1.793
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.611330e-02	1.793
Signaling by PDGF	R-HSA-186797	1.691943e-02	1.772
Striated Muscle Contraction	R-HSA-390522	1.775538e-02	1.751
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.795184e-02	1.746
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.848922e-02	1.733
Signaling by GSK3beta mutants	R-HSA-5339716	1.902433e-02	1.721
Axon guidance	R-HSA-422475	2.230647e-02	1.652
MET activates RAS signaling	R-HSA-8851805	2.247568e-02	1.648
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.247568e-02	1.648
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.247568e-02	1.648
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.247568e-02	1.648
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.247568e-02	1.648
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.247568e-02	1.648
GRB2 events in EGFR signaling	R-HSA-179812	2.247568e-02	1.648
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.247568e-02	1.648
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	2.395016e-02	1.621
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.501802e-02	1.602
L1CAM interactions	R-HSA-373760	2.547116e-02	1.594
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.666106e-02	1.574
PI Metabolism	R-HSA-1483255	2.732220e-02	1.563
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.822198e-02	1.549
IRS activation	R-HSA-74713	2.843303e-02	1.546
G2 Phase	R-HSA-68911	2.843303e-02	1.546
Chaperonin-mediated protein folding	R-HSA-390466	2.890788e-02	1.539
Myogenesis	R-HSA-525793	3.261368e-02	1.487
Intracellular signaling by second messengers	R-HSA-9006925	3.218053e-02	1.492
VEGFR2 mediated cell proliferation	R-HSA-5218921	2.954838e-02	1.529
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.185969e-02	1.497
Nervous system development	R-HSA-9675108	2.985167e-02	1.525
Erythropoietin activates RAS	R-HSA-9027284	3.473038e-02	1.459
Beta-catenin phosphorylation cascade	R-HSA-196299	3.473038e-02	1.459
SHC1 events in EGFR signaling	R-HSA-180336	3.473038e-02	1.459
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	3.473038e-02	1.459
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	3.473038e-02	1.459
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.605402e-02	1.443
Signaling by ALK in cancer	R-HSA-9700206	3.605402e-02	1.443
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.625266e-02	1.441
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.625266e-02	1.441
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	3.625266e-02	1.441
Signaling by FGFR1 in disease	R-HSA-5655302	3.759939e-02	1.425
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.288674e-02	1.368
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.337024e-02	1.363
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.337024e-02	1.363
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.337024e-02	1.363
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.337024e-02	1.363
Signaling by NOTCH1	R-HSA-1980143	3.946693e-02	1.404
RAB geranylgeranylation	R-HSA-8873719	4.337024e-02	1.363
Protein folding	R-HSA-391251	3.898214e-02	1.409
Platelet degranulation	R-HSA-114608	4.212237e-02	1.375
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.337024e-02	1.363
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	4.445890e-02	1.352
GRB2 events in ERBB2 signaling	R-HSA-1963640	4.445890e-02	1.352
Regulation of NFE2L2 gene expression	R-HSA-9818749	4.479315e-02	1.349
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	4.479315e-02	1.349
Signaling by ERBB2 in Cancer	R-HSA-1227990	4.667120e-02	1.331
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	5.399174e-02	1.268
Cohesin Loading onto Chromatin	R-HSA-2470946	5.399174e-02	1.268
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	5.399174e-02	1.268
Signaling by EGFRvIII in Cancer	R-HSA-5637812	4.977735e-02	1.303
Constitutive Signaling by EGFRvIII	R-HSA-5637810	4.977735e-02	1.303
Transcriptional regulation by RUNX3	R-HSA-8878159	5.116907e-02	1.291
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	5.466837e-02	1.262
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.453742e-02	1.263
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	5.399174e-02	1.268
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.898597e-02	1.310
Signaling by WNT in cancer	R-HSA-4791275	5.477808e-02	1.261
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	5.478569e-02	1.261
Signaling by ERBB2 ECD mutants	R-HSA-9665348	5.539046e-02	1.257
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	5.539046e-02	1.257
Tie2 Signaling	R-HSA-210993	5.539046e-02	1.257
Interleukin-1 family signaling	R-HSA-446652	5.595454e-02	1.252
Cell junction organization	R-HSA-446728	5.666652e-02	1.247
Glycolysis	R-HSA-70171	5.809078e-02	1.236
Intraflagellar transport	R-HSA-5620924	5.979586e-02	1.223
Drug-mediated inhibition of MET activation	R-HSA-9734091	7.158504e-02	1.145
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	7.158504e-02	1.145
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	7.158504e-02	1.145
Diseases of Telomere Maintenance	R-HSA-9673013	7.158504e-02	1.145
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	7.158504e-02	1.145
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	7.158504e-02	1.145
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	7.158504e-02	1.145
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	7.158504e-02	1.145
Hereditary fructose intolerance	R-HSA-5657560	7.158504e-02	1.145
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	7.158504e-02	1.145
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	7.158504e-02	1.145
Type I hemidesmosome assembly	R-HSA-446107	6.378927e-02	1.195
Signaling by MRAS-complex mutants	R-HSA-9660537	6.378927e-02	1.195
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	6.378927e-02	1.195
ARMS-mediated activation	R-HSA-170984	7.412999e-02	1.130
Regulated proteolysis of p75NTR	R-HSA-193692	7.412999e-02	1.130
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	7.412999e-02	1.130
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	8.063879e-02	1.093
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	7.392385e-02	1.131
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	7.392385e-02	1.131
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	8.330095e-02	1.079
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	6.346423e-02	1.197
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	8.421838e-02	1.075
PIP3 activates AKT signaling	R-HSA-1257604	8.363715e-02	1.078
Regulation of RAS by GAPs	R-HSA-5658442	6.725651e-02	1.172
Activation of RAS in B cells	R-HSA-1169092	6.378927e-02	1.195
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	7.412999e-02	1.130
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	8.063879e-02	1.093
Signalling to ERKs	R-HSA-187687	7.310865e-02	1.136
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	6.661780e-02	1.176
Membrane Trafficking	R-HSA-199991	6.297085e-02	1.201
Calmodulin induced events	R-HSA-111933	7.812128e-02	1.107
GP1b-IX-V activation signalling	R-HSA-430116	7.412999e-02	1.130
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.129115e-02	1.213
CaM pathway	R-HSA-111997	7.812128e-02	1.107
Oxidative Stress Induced Senescence	R-HSA-2559580	6.301885e-02	1.201
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	7.609870e-02	1.119
Cellular responses to stimuli	R-HSA-8953897	7.639953e-02	1.117
Interferon Signaling	R-HSA-913531	8.044274e-02	1.095
AKT phosphorylates targets in the nucleus	R-HSA-198693	7.412999e-02	1.130
Signaling by VEGF	R-HSA-194138	8.097014e-02	1.092
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.109767e-02	1.214
Signaling by NTRK3 (TRKC)	R-HSA-9034015	8.063879e-02	1.093
XBP1(S) activates chaperone genes	R-HSA-381038	6.688661e-02	1.175
Transcriptional Regulation by MECP2	R-HSA-8986944	8.237892e-02	1.084
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.689594e-02	1.114
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	8.421838e-02	1.075
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	8.496144e-02	1.071
Regulation of CDH11 function	R-HSA-9762292	8.496144e-02	1.071
PI3K/AKT activation	R-HSA-198203	8.496144e-02	1.071
Signal attenuation	R-HSA-74749	8.496144e-02	1.071
NFG and proNGF binds to p75NTR	R-HSA-205017	1.054354e-01	0.977
Defective GFPT1 causes CMSTA1	R-HSA-4085023	1.054354e-01	0.977
PTEN Loss of Function in Cancer	R-HSA-5674404	1.054354e-01	0.977
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	1.054354e-01	0.977
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	1.054354e-01	0.977
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	1.054354e-01	0.977
Defective SLC12A3 causes Gitelman syndrome (GS)	R-HSA-5619087	1.054354e-01	0.977
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	1.054354e-01	0.977
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	1.054354e-01	0.977
XAV939 stabilizes AXIN	R-HSA-5545619	1.054354e-01	0.977
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.380536e-01	0.860
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	R-HSA-5619104	1.380536e-01	0.860
Axonal growth stimulation	R-HSA-209563	1.694844e-01	0.771
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	1.694844e-01	0.771
MET interacts with TNS proteins	R-HSA-8875513	1.694844e-01	0.771
Defective GCLC causes HAGGSD	R-HSA-5578999	1.694844e-01	0.771
MET activates PTPN11	R-HSA-8865999	1.694844e-01	0.771
Signalling to STAT3	R-HSA-198745	1.694844e-01	0.771
Defective ABCC2 causes DJS	R-HSA-5679001	1.694844e-01	0.771
NADE modulates death signalling	R-HSA-205025	1.997708e-01	0.699
HCN channels	R-HSA-1296061	1.997708e-01	0.699
Nucleotide catabolism defects	R-HSA-9735786	1.997708e-01	0.699
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.997708e-01	0.699
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.997708e-01	0.699
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.997708e-01	0.699
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.997708e-01	0.699
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	1.997708e-01	0.699
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.997708e-01	0.699
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	9.623423e-02	1.017
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	9.623423e-02	1.017
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	9.623423e-02	1.017
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	2.289546e-01	0.640
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.289546e-01	0.640
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.289546e-01	0.640
p75NTR recruits signalling complexes	R-HSA-209543	1.199208e-01	0.921
Plus-strand DNA synthesis	R-HSA-164525	2.570758e-01	0.590
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.570758e-01	0.590
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	2.570758e-01	0.590
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	2.570758e-01	0.590
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	2.570758e-01	0.590
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.322499e-01	0.879
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.841731e-01	0.546
Erythropoietin activates STAT5	R-HSA-9027283	2.841731e-01	0.546
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	R-HSA-3656244	2.841731e-01	0.546
Uncoating of the HIV Virion	R-HSA-162585	2.841731e-01	0.546
Defective ST3GAL3 causes MCT12 and EIEE15	R-HSA-3656243	2.841731e-01	0.546
Defective CHST6 causes MCDC1	R-HSA-3656225	2.841731e-01	0.546
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	2.841731e-01	0.546
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	1.576873e-01	0.802
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.576873e-01	0.802
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	3.102836e-01	0.508
RUNX3 regulates WNT signaling	R-HSA-8951430	3.102836e-01	0.508
MET activates PI3K/AKT signaling	R-HSA-8851907	3.102836e-01	0.508
Regulation of PTEN localization	R-HSA-8948747	3.102836e-01	0.508
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.102836e-01	0.508
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.102836e-01	0.508
IFNG signaling activates MAPKs	R-HSA-9732724	3.102836e-01	0.508
Recycling of eIF2:GDP	R-HSA-72731	3.102836e-01	0.508
Reverse Transcription of HIV RNA	R-HSA-162589	3.354432e-01	0.474
Minus-strand DNA synthesis	R-HSA-164516	3.354432e-01	0.474
EGFR interacts with phospholipase C-gamma	R-HSA-212718	3.354432e-01	0.474
MET receptor recycling	R-HSA-8875656	3.354432e-01	0.474
Signaling by Erythropoietin	R-HSA-9006335	1.426561e-01	0.846
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.512920e-01	0.820
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.596865e-01	0.444
ALK mutants bind TKIs	R-HSA-9700645	3.596865e-01	0.444
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.600894e-01	0.796
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.600894e-01	0.796
Negative regulation of MET activity	R-HSA-6807004	2.379032e-01	0.624
IPs transport between nucleus and cytosol	R-HSA-1855170	1.781270e-01	0.749
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.781270e-01	0.749
Binding and entry of HIV virion	R-HSA-173107	3.830468e-01	0.417
MET activates RAP1 and RAC1	R-HSA-8875555	3.830468e-01	0.417
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.830468e-01	0.417
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.873465e-01	0.727
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.652242e-01	0.576
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.061365e-01	0.686
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	4.055563e-01	0.392
RHOBTB3 ATPase cycle	R-HSA-9706019	4.055563e-01	0.392
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.273757e-01	0.895
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.273757e-01	0.895
AURKA Activation by TPX2	R-HSA-8854518	1.438865e-01	0.842
Deadenylation of mRNA	R-HSA-429947	3.061609e-01	0.514
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.272458e-01	0.369
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.272458e-01	0.369
Meiotic synapsis	R-HSA-1221632	1.933536e-01	0.714
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.448464e-01	0.611
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.547045e-01	0.594
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.856623e-01	0.731
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.317576e-01	0.635
Processive synthesis on the C-strand of the telomere	R-HSA-174414	3.466471e-01	0.460
Centrosome maturation	R-HSA-380287	1.983374e-01	0.703
Regulation of PTEN gene transcription	R-HSA-8943724	2.476170e-01	0.606
Late endosomal microautophagy	R-HSA-9615710	3.732066e-01	0.428
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	3.147038e-01	0.502
Nucleosome assembly	R-HSA-774815	3.147038e-01	0.502
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	3.993181e-01	0.399
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.545669e-01	0.450
Translation initiation complex formation	R-HSA-72649	4.047595e-01	0.393
Ribosomal scanning and start codon recognition	R-HSA-72702	4.243887e-01	0.372
Post-translational protein phosphorylation	R-HSA-8957275	3.805351e-01	0.420
Signaling by EGFR in Cancer	R-HSA-1643713	1.178225e-01	0.929
Signaling by MET	R-HSA-6806834	2.312269e-01	0.636
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.405875e-01	0.852
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.107441e-01	0.676
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.873465e-01	0.727
Regulation of PTEN stability and activity	R-HSA-8948751	3.948709e-01	0.404
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.652242e-01	0.576
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	9.623423e-02	1.017
Neutrophil degranulation	R-HSA-6798695	8.736153e-02	1.059
Termination of translesion DNA synthesis	R-HSA-5656169	3.732066e-01	0.428
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.080467e-01	0.511
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	8.864476e-02	1.052
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	2.745753e-01	0.561
p75NTR regulates axonogenesis	R-HSA-193697	3.596865e-01	0.444
Chromosome Maintenance	R-HSA-73886	2.391604e-01	0.621
EGFR downregulation	R-HSA-182971	1.600894e-01	0.796
p75NTR signals via NF-kB	R-HSA-193639	1.576873e-01	0.802
Axonal growth inhibition (RHOA activation)	R-HSA-193634	3.354432e-01	0.474
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	2.745753e-01	0.561
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	4.249099e-01	0.372
GAB1 signalosome	R-HSA-180292	2.107441e-01	0.676
Regulation of localization of FOXO transcription factors	R-HSA-9614399	9.623423e-02	1.017
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.289546e-01	0.640
Co-inhibition by CTLA4	R-HSA-389513	2.379032e-01	0.624
PTEN Regulation	R-HSA-6807070	3.603587e-01	0.443
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.022667e-01	0.990
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.426561e-01	0.846
p75 NTR receptor-mediated signalling	R-HSA-193704	1.189988e-01	0.924
Regulation of gap junction activity	R-HSA-191650	1.997708e-01	0.699
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	1.341922e-01	0.872
MASTL Facilitates Mitotic Progression	R-HSA-2465910	3.596865e-01	0.444
HSF1-dependent transactivation	R-HSA-3371571	1.785932e-01	0.748
HCMV Early Events	R-HSA-9609690	1.093328e-01	0.961
Budding and maturation of HIV virion	R-HSA-162588	3.993181e-01	0.399
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	3.993181e-01	0.399
Long-term potentiation	R-HSA-9620244	1.099376e-01	0.959
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.501564e-01	0.602
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.448464e-01	0.611
Sema4D in semaphorin signaling	R-HSA-400685	1.099376e-01	0.959
Rab regulation of trafficking	R-HSA-9007101	1.187765e-01	0.925
Clathrin-mediated endocytosis	R-HSA-8856828	3.902874e-01	0.409
PTK6 Activates STAT3	R-HSA-8849474	2.289546e-01	0.640
PTK6 Expression	R-HSA-8849473	3.102836e-01	0.508
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.272458e-01	0.369
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.309729e-01	0.883
Polymerase switching on the C-strand of the telomere	R-HSA-174411	3.197260e-01	0.495
Signaling by NOTCH3	R-HSA-9012852	4.146003e-01	0.382
Prolonged ERK activation events	R-HSA-169893	1.707256e-01	0.768
MAPK6/MAPK4 signaling	R-HSA-5687128	1.357399e-01	0.867
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.277157e-01	0.485
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.178225e-01	0.929
MET Receptor Activation	R-HSA-6806942	2.841731e-01	0.546
Diseases of mitotic cell cycle	R-HSA-9675126	1.690379e-01	0.772
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.332258e-01	0.477
Deadenylation-dependent mRNA decay	R-HSA-429914	2.396566e-01	0.620
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.756361e-01	0.755
Processing of DNA double-strand break ends	R-HSA-5693607	4.209743e-01	0.376
IRS-related events triggered by IGF1R	R-HSA-2428928	2.556339e-01	0.592
NRIF signals cell death from the nucleus	R-HSA-205043	1.448508e-01	0.839
NRAGE signals death through JNK	R-HSA-193648	9.256998e-02	1.034
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.646170e-01	0.577
Mitophagy	R-HSA-5205647	1.966864e-01	0.706
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.572198e-01	0.803
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.199208e-01	0.921
Regulation of PTEN mRNA translation	R-HSA-8943723	2.925450e-01	0.534
Homology Directed Repair	R-HSA-5693538	3.667673e-01	0.436
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.061365e-01	0.686
Degradation of beta-catenin by the destruction complex	R-HSA-195253	3.295602e-01	0.482
TCF dependent signaling in response to WNT	R-HSA-201681	3.377978e-01	0.471
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	1.054354e-01	0.977
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.380536e-01	0.860
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.997708e-01	0.699
Signaling by APC mutants	R-HSA-4839744	9.623423e-02	1.017
Suppression of autophagy	R-HSA-9636569	2.289546e-01	0.640
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.079019e-01	0.967
Signaling by AMER1 mutants	R-HSA-4839748	1.079019e-01	0.967
Signaling by AXIN mutants	R-HSA-4839735	1.079019e-01	0.967
Pentose phosphate pathway disease	R-HSA-6791465	2.570758e-01	0.590
Noncanonical activation of NOTCH3	R-HSA-9017802	2.570758e-01	0.590
Ceramide signalling	R-HSA-193681	2.570758e-01	0.590
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.322499e-01	0.879
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	1.707256e-01	0.768
Interleukin-23 signaling	R-HSA-9020933	3.354432e-01	0.474
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.107441e-01	0.676
Downregulation of ERBB2 signaling	R-HSA-8863795	1.512920e-01	0.820
Unwinding of DNA	R-HSA-176974	3.596865e-01	0.444
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	2.515542e-01	0.599
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.830468e-01	0.417
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.253286e-01	0.647
NF-kB is activated and signals survival	R-HSA-209560	4.272458e-01	0.369
ERKs are inactivated	R-HSA-202670	4.272458e-01	0.369
Phase 0 - rapid depolarisation	R-HSA-5576892	3.599778e-01	0.444
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.147038e-01	0.502
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	3.348384e-01	0.475
Meiosis	R-HSA-1500620	2.655344e-01	0.576
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.441631e-01	0.463
HCMV Infection	R-HSA-9609646	3.053199e-01	0.515
Chaperone Mediated Autophagy	R-HSA-9613829	2.107441e-01	0.676
Somitogenesis	R-HSA-9824272	3.147038e-01	0.502
IGF1R signaling cascade	R-HSA-2428924	2.799762e-01	0.553
Interleukin-20 family signaling	R-HSA-8854691	2.925450e-01	0.534
Extra-nuclear estrogen signaling	R-HSA-9009391	2.397473e-01	0.620
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	8.760732e-02	1.057
IRS-mediated signalling	R-HSA-112399	2.239247e-01	0.650
Heme signaling	R-HSA-9707616	2.637026e-01	0.579
Insulin receptor signalling cascade	R-HSA-74751	2.799762e-01	0.553
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	2.289546e-01	0.640
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	2.379032e-01	0.624
Transcriptional Regulation by E2F6	R-HSA-8953750	2.448464e-01	0.611
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.881720e-01	0.540
Signaling by NOTCH	R-HSA-157118	2.635747e-01	0.579
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.379032e-01	0.624
EPH-Ephrin signaling	R-HSA-2682334	1.820868e-01	0.740
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.667847e-01	0.778
Activation of NOXA and translocation to mitochondria	R-HSA-111448	1.997708e-01	0.699
Muscarinic acetylcholine receptors	R-HSA-390648	2.289546e-01	0.640
p38MAPK events	R-HSA-171007	1.576873e-01	0.802
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.102836e-01	0.508
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.102836e-01	0.508
Downregulation of ERBB4 signaling	R-HSA-1253288	3.354432e-01	0.474
Interleukin-21 signaling	R-HSA-9020958	3.596865e-01	0.444
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	3.596865e-01	0.444
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.873465e-01	0.727
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	2.788939e-01	0.555
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.580339e-01	0.588
DNA Double-Strand Break Repair	R-HSA-5693532	1.899384e-01	0.721
Response of endothelial cells to shear stress	R-HSA-9860931	1.400010e-01	0.854
Semaphorin interactions	R-HSA-373755	1.273757e-01	0.895
Interleukin-9 signaling	R-HSA-8985947	3.354432e-01	0.474
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.572198e-01	0.803
Mitotic Prophase	R-HSA-68875	3.798475e-01	0.420
RAS processing	R-HSA-9648002	9.414953e-02	1.026
Signaling by ALK	R-HSA-201556	2.448464e-01	0.611
Cellular response to heat stress	R-HSA-3371556	1.338903e-01	0.873
Signaling by WNT	R-HSA-195721	4.020055e-01	0.396
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.707256e-01	0.768
mTORC1-mediated signalling	R-HSA-166208	2.788939e-01	0.555
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	3.332258e-01	0.477
Smooth Muscle Contraction	R-HSA-445355	3.948709e-01	0.404
DNA Repair	R-HSA-73894	3.406595e-01	0.468
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	1.178225e-01	0.929
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.983374e-01	0.703
Vesicle-mediated transport	R-HSA-5653656	3.005240e-01	0.522
ER to Golgi Anterograde Transport	R-HSA-199977	2.731089e-01	0.564
Signaling by Insulin receptor	R-HSA-74752	3.296669e-01	0.482
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.462265e-01	0.461
Cellular responses to mechanical stimuli	R-HSA-9855142	1.012447e-01	0.995
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	1.694844e-01	0.771
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	1.997708e-01	0.699
Inositol transporters	R-HSA-429593	2.289546e-01	0.640
Reduction of cytosolic Ca++ levels	R-HSA-418359	1.079019e-01	0.967
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	2.570758e-01	0.590
Signalling to p38 via RIT and RIN	R-HSA-187706	2.570758e-01	0.590
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	1.448508e-01	0.839
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	3.354432e-01	0.474
TGFBR3 PTM regulation	R-HSA-9839383	3.354432e-01	0.474
NS1 Mediated Effects on Host Pathways	R-HSA-168276	9.414953e-02	1.026
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	3.830468e-01	0.417
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	3.061609e-01	0.514
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	4.272458e-01	0.369
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.272458e-01	0.369
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.646170e-01	0.577
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	3.332258e-01	0.477
Metabolism of non-coding RNA	R-HSA-194441	2.396566e-01	0.620
snRNP Assembly	R-HSA-191859	2.396566e-01	0.620
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.863231e-01	0.413
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.202570e-01	0.920
DNA strand elongation	R-HSA-69190	4.121830e-01	0.385
Death Receptor Signaling	R-HSA-73887	3.103713e-01	0.508
Diseases of programmed cell death	R-HSA-9645723	1.555996e-01	0.808
DAG and IP3 signaling	R-HSA-1489509	1.368829e-01	0.864
Muscle contraction	R-HSA-397014	9.650925e-02	1.015
Cilium Assembly	R-HSA-5617833	2.532735e-01	0.596
S Phase	R-HSA-69242	4.202463e-01	0.376
Cellular responses to stress	R-HSA-2262752	1.261524e-01	0.899
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	1.099376e-01	0.959
Sensory processing of sound	R-HSA-9659379	1.083958e-01	0.965
Signalling to RAS	R-HSA-167044	2.515542e-01	0.599
Sphingolipid catabolism	R-HSA-9845614	3.332258e-01	0.477
Ca-dependent events	R-HSA-111996	1.177078e-01	0.929
Ion homeostasis	R-HSA-5578775	2.161630e-01	0.665
Regulation of CDH1 Expression and Function	R-HSA-9764265	4.207784e-01	0.376
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	4.207784e-01	0.376
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.052340e-01	0.392
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.259108e-01	0.900
Rap1 signalling	R-HSA-392517	2.242924e-01	0.649
ERK/MAPK targets	R-HSA-198753	2.515542e-01	0.599
Nuclear import of Rev protein	R-HSA-180746	1.966864e-01	0.706
TBC/RABGAPs	R-HSA-8854214	2.945963e-01	0.531
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.732066e-01	0.428
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.095993e-01	0.388
FGFR1 mutant receptor activation	R-HSA-1839124	1.781270e-01	0.749
Ub-specific processing proteases	R-HSA-5689880	1.817559e-01	0.741
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.249099e-01	0.372
Transmission across Chemical Synapses	R-HSA-112315	1.438503e-01	0.842
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	2.788939e-01	0.555
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	2.476170e-01	0.606
G0 and Early G1	R-HSA-1538133	4.121830e-01	0.385
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	4.127367e-01	0.384
Neuronal System	R-HSA-112316	1.048370e-01	0.979
Dopamine receptors	R-HSA-390651	1.997708e-01	0.699
Regulation of HMOX1 expression and activity	R-HSA-9707587	1.997708e-01	0.699
Activated NTRK3 signals through RAS	R-HSA-9034864	9.623423e-02	1.017
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	2.289546e-01	0.640
Activation of RAC1	R-HSA-428540	1.079019e-01	0.967
Activated NTRK2 signals through RAS	R-HSA-9026519	1.079019e-01	0.967
Sodium-coupled phosphate cotransporters	R-HSA-427652	2.570758e-01	0.590
Phase 3 - rapid repolarisation	R-HSA-5576890	3.102836e-01	0.508
SHC1 events in ERBB4 signaling	R-HSA-1250347	1.839339e-01	0.735
Sodium/Proton exchangers	R-HSA-425986	3.354432e-01	0.474
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	9.256998e-02	1.034
SHC-mediated cascade:FGFR3	R-HSA-5654704	2.515542e-01	0.599
Interleukin-27 signaling	R-HSA-9020956	3.830468e-01	0.417
SHC-mediated cascade:FGFR4	R-HSA-5654719	2.652242e-01	0.576
Bicarbonate transporters	R-HSA-425381	4.055563e-01	0.392
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.925450e-01	0.534
SHC-mediated cascade:FGFR1	R-HSA-5654688	3.061609e-01	0.514
Interactions of Rev with host cellular proteins	R-HSA-177243	2.547045e-01	0.594
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.547045e-01	0.594
Hedgehog 'off' state	R-HSA-5610787	1.230609e-01	0.910
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.646170e-01	0.577
Glucose metabolism	R-HSA-70326	1.187765e-01	0.925
SHC-mediated cascade:FGFR2	R-HSA-5654699	3.466471e-01	0.460
PLC beta mediated events	R-HSA-112043	2.556339e-01	0.592
Trafficking of AMPA receptors	R-HSA-399719	3.993181e-01	0.399
DNA Double Strand Break Response	R-HSA-5693606	3.046586e-01	0.516
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.462265e-01	0.461
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.659769e-01	0.437
Protein-protein interactions at synapses	R-HSA-6794362	1.357399e-01	0.867
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.961906e-01	0.402
Platelet activation, signaling and aggregation	R-HSA-76002	4.108471e-01	0.386
FLT3 signaling in disease	R-HSA-9682385	2.156871e-01	0.666
Late Phase of HIV Life Cycle	R-HSA-162599	3.842936e-01	0.415
Reproduction	R-HSA-1474165	3.013182e-01	0.521
Signaling by NTRK1 (TRKA)	R-HSA-187037	8.932307e-02	1.049
Regulation of NPAS4 gene transcription	R-HSA-9768777	3.596865e-01	0.444
FRS-mediated FGFR3 signaling	R-HSA-5654706	2.652242e-01	0.576
FRS-mediated FGFR4 signaling	R-HSA-5654712	2.788939e-01	0.555
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.272458e-01	0.369
FRS-mediated FGFR1 signaling	R-HSA-5654693	3.197260e-01	0.495
FRS-mediated FGFR2 signaling	R-HSA-5654700	3.599778e-01	0.444
Golgi-to-ER retrograde transport	R-HSA-8856688	1.891772e-01	0.723
Cell Cycle Checkpoints	R-HSA-69620	9.953229e-02	1.002
C-type lectin receptors (CLRs)	R-HSA-5621481	2.774760e-01	0.557
ESR-mediated signaling	R-HSA-8939211	2.514480e-01	0.600
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.672378e-01	0.777
Signaling by ERBB4	R-HSA-1236394	8.801941e-02	1.055
Co-stimulation by CD28	R-HSA-389356	1.572198e-01	0.803
Generic Transcription Pathway	R-HSA-212436	3.299691e-01	0.482
Organelle biogenesis and maintenance	R-HSA-1852241	3.854939e-01	0.414
SHC-related events triggered by IGF1R	R-HSA-2428933	1.199208e-01	0.921
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.570758e-01	0.590
Nef and signal transduction	R-HSA-164944	2.841731e-01	0.546
Syndecan interactions	R-HSA-3000170	9.481991e-02	1.023
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	3.354432e-01	0.474
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.596865e-01	0.444
Synthesis of PIPs at the ER membrane	R-HSA-1483248	4.055563e-01	0.392
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.350514e-01	0.629
Pentose phosphate pathway	R-HSA-71336	2.448464e-01	0.611
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.247713e-01	0.488
G-protein mediated events	R-HSA-112040	3.046586e-01	0.516
Signaling by KIT in disease	R-HSA-9669938	8.760732e-02	1.057
EPHB-mediated forward signaling	R-HSA-3928662	3.046430e-01	0.516
Cellular Senescence	R-HSA-2559583	2.100274e-01	0.678
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.121830e-01	0.385
Host Interactions of HIV factors	R-HSA-162909	4.060125e-01	0.391
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	3.348384e-01	0.475
Gluconeogenesis	R-HSA-70263	3.448984e-01	0.462
Signaling by FGFR2	R-HSA-5654738	4.127367e-01	0.384
Signaling by NTRKs	R-HSA-166520	1.691754e-01	0.772
Opioid Signalling	R-HSA-111885	2.580339e-01	0.588
Inositol phosphate metabolism	R-HSA-1483249	3.148135e-01	0.502
Immune System	R-HSA-168256	3.380073e-01	0.471
Cellular response to mitochondrial stress	R-HSA-9840373	3.596865e-01	0.444
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	3.596865e-01	0.444
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	9.720538e-02	1.012
DARPP-32 events	R-HSA-180024	3.732066e-01	0.428
COPI-mediated anterograde transport	R-HSA-6807878	2.102161e-01	0.677
Signaling by Hedgehog	R-HSA-5358351	3.543922e-01	0.451
Zinc transporters	R-HSA-435354	1.448508e-01	0.839
Interleukin-7 signaling	R-HSA-1266695	1.099376e-01	0.959
Signaling by SCF-KIT	R-HSA-1433557	1.239630e-01	0.907
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	3.993181e-01	0.399
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	2.637026e-01	0.579
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	2.289546e-01	0.640
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	1.199208e-01	0.921
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.596865e-01	0.444
Regulation of MECP2 expression and activity	R-HSA-9022692	1.781270e-01	0.749
Receptor Mediated Mitophagy	R-HSA-8934903	3.830468e-01	0.417
Integration of provirus	R-HSA-162592	4.272458e-01	0.369
Signaling by FGFR in disease	R-HSA-1226099	1.919626e-01	0.717
FLT3 Signaling	R-HSA-9607240	1.056283e-01	0.976
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.123517e-01	0.949
Hemostasis	R-HSA-109582	2.444837e-01	0.612
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	2.925450e-01	0.534
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	3.849398e-01	0.415
Downstream signaling of activated FGFR3	R-HSA-5654708	3.732066e-01	0.428
Downstream signaling of activated FGFR4	R-HSA-5654716	3.863231e-01	0.413
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.805351e-01	0.420
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.805351e-01	0.420
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.805351e-01	0.420
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.102836e-01	0.508
Synaptic adhesion-like molecules	R-HSA-8849932	2.107441e-01	0.676
RET signaling	R-HSA-8853659	2.156871e-01	0.666
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.732066e-01	0.428
Platelet calcium homeostasis	R-HSA-418360	3.732066e-01	0.428
Signaling by FGFR4	R-HSA-5654743	2.945963e-01	0.531
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	3.466471e-01	0.460
G1 Phase	R-HSA-69236	3.046430e-01	0.516
Cyclin D associated events in G1	R-HSA-69231	3.046430e-01	0.516
Ion transport by P-type ATPases	R-HSA-936837	2.799762e-01	0.553
Signaling by FGFR3	R-HSA-5654741	3.147038e-01	0.502
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	9.481991e-02	1.023
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.839339e-01	0.735
Platelet sensitization by LDL	R-HSA-432142	2.107441e-01	0.676
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	4.249099e-01	0.372
SLC transporter disorders	R-HSA-5619102	2.533048e-01	0.596
Transcriptional Regulation by TP53	R-HSA-3700989	9.986451e-02	1.001
Growth hormone receptor signaling	R-HSA-982772	9.481991e-02	1.023
Metal ion SLC transporters	R-HSA-425410	3.448984e-01	0.462
Specification of primordial germ cells	R-HSA-9827857	1.972827e-01	0.705
Signaling by FGFR1	R-HSA-5654736	4.243887e-01	0.372
Disorders of transmembrane transporters	R-HSA-5619115	4.062722e-01	0.391
Mitochondrial calcium ion transport	R-HSA-8949215	2.652242e-01	0.576
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.107441e-01	0.676
Regulation of TP53 Activity	R-HSA-5633007	3.430982e-01	0.465
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.332258e-01	0.477
IRE1alpha activates chaperones	R-HSA-381070	8.570562e-02	1.067
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.830468e-01	0.417
Unfolded Protein Response (UPR)	R-HSA-381119	1.311294e-01	0.882
Signaling by FGFR4 in disease	R-HSA-5655291	1.448508e-01	0.839
ISG15 antiviral mechanism	R-HSA-1169408	3.712432e-01	0.430
DAP12 signaling	R-HSA-2424491	3.863231e-01	0.413
Signaling by NTRK2 (TRKB)	R-HSA-9006115	3.466471e-01	0.460
Dissolution of Fibrin Clot	R-HSA-75205	4.055563e-01	0.392
Signaling by FGFR3 in disease	R-HSA-5655332	3.466471e-01	0.460
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	3.061609e-01	0.514
MHC class II antigen presentation	R-HSA-2132295	1.417980e-01	0.848
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	4.291840e-01	0.367
MITF-M-dependent gene expression	R-HSA-9856651	4.321999e-01	0.364
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	4.332172e-01	0.363
Nuclear Envelope Breakdown	R-HSA-2980766	4.341200e-01	0.362
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.374918e-01	0.359
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	4.374918e-01	0.359
KEAP1-NFE2L2 pathway	R-HSA-9755511	4.381650e-01	0.358
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	4.384689e-01	0.358
Deubiquitination	R-HSA-5688426	4.437380e-01	0.353
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	4.437899e-01	0.353
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	4.455081e-01	0.351
Platelet homeostasis	R-HSA-418346	4.456394e-01	0.351
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	4.481452e-01	0.349
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.481452e-01	0.349
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	4.481452e-01	0.349
Scavenging by Class F Receptors	R-HSA-3000484	4.481452e-01	0.349
Polymerase switching	R-HSA-69091	4.481452e-01	0.349
Leading Strand Synthesis	R-HSA-69109	4.481452e-01	0.349
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.481452e-01	0.349
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.481452e-01	0.349
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.481452e-01	0.349
Signaling by LTK	R-HSA-9842663	4.481452e-01	0.349
Interleukin-15 signaling	R-HSA-8983432	4.481452e-01	0.349
RUNX3 regulates p14-ARF	R-HSA-8951936	4.481452e-01	0.349
Pervasive developmental disorders	R-HSA-9005895	4.481452e-01	0.349
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	4.481452e-01	0.349
Disorders of Nervous System Development	R-HSA-9697154	4.481452e-01	0.349
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	4.481452e-01	0.349
Interleukin-35 Signalling	R-HSA-8984722	4.481452e-01	0.349
OAS antiviral response	R-HSA-8983711	4.481452e-01	0.349
Dual Incision in GG-NER	R-HSA-5696400	4.499224e-01	0.347
Signaling by NOTCH2	R-HSA-1980145	4.499224e-01	0.347
NOD1/2 Signaling Pathway	R-HSA-168638	4.499224e-01	0.347
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	4.499224e-01	0.347
RNA Polymerase II Transcription	R-HSA-73857	4.503413e-01	0.346
mRNA Splicing	R-HSA-72172	4.521204e-01	0.345
Extension of Telomeres	R-HSA-180786	4.533943e-01	0.344
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.533943e-01	0.344
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.599098e-01	0.337
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	4.599098e-01	0.337
Regulation of Apoptosis	R-HSA-169911	4.621960e-01	0.335
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	4.621960e-01	0.335
PERK regulates gene expression	R-HSA-381042	4.621960e-01	0.335
Downstream signaling of activated FGFR2	R-HSA-5654696	4.621960e-01	0.335
Downstream signaling of activated FGFR1	R-HSA-5654687	4.621960e-01	0.335
Oncogene Induced Senescence	R-HSA-2559585	4.621960e-01	0.335
MyD88 dependent cascade initiated on endosome	R-HSA-975155	4.670057e-01	0.331
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.682833e-01	0.329
Frs2-mediated activation	R-HSA-170968	4.682833e-01	0.329
Diseases of nucleotide metabolism	R-HSA-9735804	4.682833e-01	0.329
Interleukin-6 signaling	R-HSA-1059683	4.682833e-01	0.329
Formation of axial mesoderm	R-HSA-9796292	4.682833e-01	0.329
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	4.682833e-01	0.329
CD28 dependent Vav1 pathway	R-HSA-389359	4.682833e-01	0.329
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	4.682833e-01	0.329
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	4.682833e-01	0.329
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.697141e-01	0.328
Formation of paraxial mesoderm	R-HSA-9793380	4.723913e-01	0.326
Viral Messenger RNA Synthesis	R-HSA-168325	4.723913e-01	0.326
MAP kinase activation	R-HSA-450294	4.723913e-01	0.326
HIV Life Cycle	R-HSA-162587	4.737145e-01	0.324
TCR signaling	R-HSA-202403	4.740730e-01	0.324
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	4.740730e-01	0.324
MyD88-independent TLR4 cascade	R-HSA-166166	4.740730e-01	0.324
Regulation of TP53 Degradation	R-HSA-6804757	4.743074e-01	0.324
RUNX2 regulates bone development	R-HSA-8941326	4.743074e-01	0.324
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.795881e-01	0.319
tRNA processing in the nucleus	R-HSA-6784531	4.817767e-01	0.317
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	4.862523e-01	0.313
Degradation of AXIN	R-HSA-4641257	4.862523e-01	0.313
Metabolism of folate and pterines	R-HSA-196757	4.862523e-01	0.313
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	4.876876e-01	0.312
cGMP effects	R-HSA-418457	4.876876e-01	0.312
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	4.876876e-01	0.312
Signal regulatory protein family interactions	R-HSA-391160	4.876876e-01	0.312
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	4.876876e-01	0.312
HDL assembly	R-HSA-8963896	4.876876e-01	0.312
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.950852e-01	0.305
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.003050e-01	0.301
Beta-catenin independent WNT signaling	R-HSA-3858494	5.025053e-01	0.299
Estrogen-dependent gene expression	R-HSA-9018519	5.025053e-01	0.299
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.063850e-01	0.296
ERBB2 Regulates Cell Motility	R-HSA-6785631	5.063850e-01	0.296
Translesion synthesis by REV1	R-HSA-110312	5.063850e-01	0.296
Telomere C-strand synthesis initiation	R-HSA-174430	5.063850e-01	0.296
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	5.063850e-01	0.296
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.063850e-01	0.296
Dopamine clearance from the synaptic cleft	R-HSA-379401	5.063850e-01	0.296
Lysosphingolipid and LPA receptors	R-HSA-419408	5.063850e-01	0.296
Spry regulation of FGF signaling	R-HSA-1295596	5.063850e-01	0.296
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	5.063850e-01	0.296
DCC mediated attractive signaling	R-HSA-418885	5.063850e-01	0.296
Formation of the anterior neural plate	R-HSA-9823739	5.063850e-01	0.296
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	5.089183e-01	0.293
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.091431e-01	0.293
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	5.096268e-01	0.293
Regulation of TP53 Expression and Degradation	R-HSA-6806003	5.096268e-01	0.293
TP53 Regulates Metabolic Genes	R-HSA-5628897	5.157777e-01	0.288
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.157777e-01	0.288
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	5.184908e-01	0.285
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	5.210500e-01	0.283
Inhibition of DNA recombination at telomere	R-HSA-9670095	5.210500e-01	0.283
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	5.210500e-01	0.283
Nuclear signaling by ERBB4	R-HSA-1251985	5.210500e-01	0.283
Adherens junctions interactions	R-HSA-418990	5.237032e-01	0.281
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	5.244011e-01	0.280
Translesion synthesis by POLI	R-HSA-5656121	5.244011e-01	0.280
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	5.244011e-01	0.280
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	5.244011e-01	0.280
Fructose catabolism	R-HSA-70350	5.244011e-01	0.280
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.244011e-01	0.280
Atorvastatin ADME	R-HSA-9754706	5.244011e-01	0.280
Negative regulation of FLT3	R-HSA-9706369	5.244011e-01	0.280
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.322937e-01	0.274
PKMTs methylate histone lysines	R-HSA-3214841	5.322937e-01	0.274
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.322937e-01	0.274
Maturation of spike protein	R-HSA-9694548	5.322937e-01	0.274
mRNA Splicing - Major Pathway	R-HSA-72163	5.352564e-01	0.271
Translesion synthesis by POLK	R-HSA-5655862	5.417607e-01	0.266
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.417607e-01	0.266
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	5.417607e-01	0.266
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.417607e-01	0.266
Biosynthesis of maresin-like SPMs	R-HSA-9027307	5.417607e-01	0.266
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.417607e-01	0.266
Disorders of Developmental Biology	R-HSA-9675151	5.417607e-01	0.266
HIV Transcription Initiation	R-HSA-167161	5.433558e-01	0.265
RNA Polymerase II Transcription Initiation	R-HSA-75953	5.433558e-01	0.265
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	5.433558e-01	0.265
Degradation of GLI1 by the proteasome	R-HSA-5610780	5.433558e-01	0.265
Intra-Golgi traffic	R-HSA-6811438	5.433558e-01	0.265
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	5.450826e-01	0.264
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	5.456821e-01	0.263
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	5.494446e-01	0.260
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	5.494446e-01	0.260
Cell-cell junction organization	R-HSA-421270	5.511548e-01	0.259
Interleukin-17 signaling	R-HSA-448424	5.537547e-01	0.257
MTOR signalling	R-HSA-165159	5.542345e-01	0.256
Cleavage of the damaged pyrimidine	R-HSA-110329	5.542345e-01	0.256
Depyrimidination	R-HSA-73928	5.542345e-01	0.256
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.584876e-01	0.253
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	5.584876e-01	0.253
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	5.584876e-01	0.253
PI3K events in ERBB2 signaling	R-HSA-1963642	5.584876e-01	0.253
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	5.584876e-01	0.253
Regulation of NPAS4 gene expression	R-HSA-9768759	5.584876e-01	0.253
Regulation of FZD by ubiquitination	R-HSA-4641263	5.584876e-01	0.253
ECM proteoglycans	R-HSA-3000178	5.623277e-01	0.250
Nuclear events mediated by NFE2L2	R-HSA-9759194	5.625931e-01	0.250
Transcriptional regulation by RUNX1	R-HSA-8878171	5.631882e-01	0.249
RNA Polymerase II Promoter Escape	R-HSA-73776	5.649284e-01	0.248
HIV Infection	R-HSA-162906	5.680289e-01	0.246
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	5.690945e-01	0.245
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	5.690945e-01	0.245
Telomere Maintenance	R-HSA-157579	5.692766e-01	0.245
Mitotic G1 phase and G1/S transition	R-HSA-453279	5.695954e-01	0.244
Transcriptional regulation by small RNAs	R-HSA-5578749	5.708001e-01	0.244
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.708001e-01	0.244
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.746050e-01	0.241
Mismatch Repair	R-HSA-5358508	5.746050e-01	0.241
Ephrin signaling	R-HSA-3928664	5.746050e-01	0.241
Regulation of TP53 Activity through Methylation	R-HSA-6804760	5.746050e-01	0.241
Proteasome assembly	R-HSA-9907900	5.754367e-01	0.240
Netrin-1 signaling	R-HSA-373752	5.754367e-01	0.240
Amine ligand-binding receptors	R-HSA-375280	5.754367e-01	0.240
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.754367e-01	0.240
DAP12 interactions	R-HSA-2172127	5.754367e-01	0.240
Signaling by FGFR	R-HSA-190236	5.765025e-01	0.239
Transport to the Golgi and subsequent modification	R-HSA-948021	5.766799e-01	0.239
Ca2+ pathway	R-HSA-4086398	5.791703e-01	0.237
Signaling by ROBO receptors	R-HSA-376176	5.817394e-01	0.235
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	5.857585e-01	0.232
Asymmetric localization of PCP proteins	R-HSA-4608870	5.857585e-01	0.232
Gastrulation	R-HSA-9758941	5.871214e-01	0.231
Signaling by NOTCH4	R-HSA-9013694	5.874370e-01	0.231
G2/M DNA damage checkpoint	R-HSA-69473	5.874370e-01	0.231
SLC-mediated transmembrane transport	R-HSA-425407	5.888046e-01	0.230
Impaired BRCA2 binding to PALB2	R-HSA-9709603	5.901350e-01	0.229
Translesion Synthesis by POLH	R-HSA-110320	5.901350e-01	0.229
Specification of the neural plate border	R-HSA-9834899	5.901350e-01	0.229
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	5.901350e-01	0.229
E2F mediated regulation of DNA replication	R-HSA-113510	5.901350e-01	0.229
The NLRP3 inflammasome	R-HSA-844456	5.901350e-01	0.229
O2/CO2 exchange in erythrocytes	R-HSA-1480926	5.901350e-01	0.229
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	5.901350e-01	0.229
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	5.901350e-01	0.229
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	5.955989e-01	0.225
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	5.958936e-01	0.225
Condensation of Prophase Chromosomes	R-HSA-2299718	5.958936e-01	0.225
Diseases of DNA repair	R-HSA-9675135	5.958936e-01	0.225
Interleukin-1 signaling	R-HSA-9020702	5.977607e-01	0.223
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.050989e-01	0.218
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.050989e-01	0.218
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.050989e-01	0.218
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.050989e-01	0.218
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.050989e-01	0.218
Keratan sulfate degradation	R-HSA-2022857	6.050989e-01	0.218
Formation of definitive endoderm	R-HSA-9823730	6.050989e-01	0.218
Signal transduction by L1	R-HSA-445144	6.050989e-01	0.218
Signaling by NODAL	R-HSA-1181150	6.050989e-01	0.218
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	6.058417e-01	0.218
G2/M Checkpoints	R-HSA-69481	6.070182e-01	0.217
Gene expression (Transcription)	R-HSA-74160	6.117764e-01	0.213
PCP/CE pathway	R-HSA-4086400	6.194466e-01	0.208
G alpha (12/13) signalling events	R-HSA-416482	6.194466e-01	0.208
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	6.195173e-01	0.208
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	6.195173e-01	0.208
Early Phase of HIV Life Cycle	R-HSA-162594	6.195173e-01	0.208
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.195173e-01	0.208
Lagging Strand Synthesis	R-HSA-69186	6.195173e-01	0.208
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	6.195173e-01	0.208
Basigin interactions	R-HSA-210991	6.195173e-01	0.208
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	6.195173e-01	0.208
Phospholipid metabolism	R-HSA-1483257	6.221612e-01	0.206
DNA Damage Bypass	R-HSA-73893	6.251779e-01	0.204
Degradation of CDH1	R-HSA-9766229	6.251779e-01	0.204
Cellular response to chemical stress	R-HSA-9711123	6.272627e-01	0.203
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.334102e-01	0.198
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	6.334102e-01	0.198
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	6.334102e-01	0.198
Glutathione synthesis and recycling	R-HSA-174403	6.334102e-01	0.198
Ribavirin ADME	R-HSA-9755088	6.334102e-01	0.198
Assembly Of The HIV Virion	R-HSA-175474	6.334102e-01	0.198
PI3K Cascade	R-HSA-109704	6.345669e-01	0.198
Signaling by FGFR2 in disease	R-HSA-5655253	6.345669e-01	0.198
MITF-M-regulated melanocyte development	R-HSA-9730414	6.354080e-01	0.197
Cardiac conduction	R-HSA-5576891	6.371096e-01	0.196
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	6.423213e-01	0.192
Interferon gamma signaling	R-HSA-877300	6.427329e-01	0.192
Activation of NF-kappaB in B cells	R-HSA-1169091	6.437710e-01	0.191
Regulation of IFNA/IFNB signaling	R-HSA-912694	6.467966e-01	0.189
FGFR2 alternative splicing	R-HSA-6803529	6.467966e-01	0.189
Fructose metabolism	R-HSA-5652084	6.467966e-01	0.189
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.467966e-01	0.189
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	6.467966e-01	0.189
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	6.527910e-01	0.185
Orc1 removal from chromatin	R-HSA-68949	6.527910e-01	0.185
Neurexins and neuroligins	R-HSA-6794361	6.527910e-01	0.185
Ion channel transport	R-HSA-983712	6.532667e-01	0.185
Cytoprotection by HMOX1	R-HSA-9707564	6.570242e-01	0.182
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	6.596950e-01	0.181
Biosynthesis of maresins	R-HSA-9018682	6.596950e-01	0.181
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	6.596950e-01	0.181
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	6.596950e-01	0.181
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	6.616282e-01	0.179
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.642108e-01	0.178
Signaling by Nuclear Receptors	R-HSA-9006931	6.656905e-01	0.177
Base-Excision Repair, AP Site Formation	R-HSA-73929	6.702838e-01	0.174
CYP2E1 reactions	R-HSA-211999	6.721231e-01	0.173
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.721231e-01	0.173
TRAF6 mediated NF-kB activation	R-HSA-933542	6.721231e-01	0.173
Interleukin-6 family signaling	R-HSA-6783589	6.721231e-01	0.173
Plasma lipoprotein assembly	R-HSA-8963898	6.721231e-01	0.173
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	6.760948e-01	0.170
Nonsense-Mediated Decay (NMD)	R-HSA-927802	6.760948e-01	0.170
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.787593e-01	0.168
Paracetamol ADME	R-HSA-9753281	6.787593e-01	0.168
Pre-NOTCH Expression and Processing	R-HSA-1912422	6.821193e-01	0.166
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	6.840981e-01	0.165
G protein gated Potassium channels	R-HSA-1296059	6.840981e-01	0.165
Activation of G protein gated Potassium channels	R-HSA-1296041	6.840981e-01	0.165
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	6.840981e-01	0.165
Tight junction interactions	R-HSA-420029	6.840981e-01	0.165
Acyl chain remodelling of PS	R-HSA-1482801	6.840981e-01	0.165
Hyaluronan degradation	R-HSA-2160916	6.840981e-01	0.165
Glycogen breakdown (glycogenolysis)	R-HSA-70221	6.840981e-01	0.165
Formation of the nephric duct	R-HSA-9830364	6.840981e-01	0.165
Laminin interactions	R-HSA-3000157	6.840981e-01	0.165
SWI/SNF chromatin remodelers	R-HSA-9932451	6.840981e-01	0.165
ATP-dependent chromatin remodelers	R-HSA-9932444	6.840981e-01	0.165
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	6.870563e-01	0.163
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	6.870563e-01	0.163
Intrinsic Pathway for Apoptosis	R-HSA-109606	6.870563e-01	0.163
Regulation of CDH1 Function	R-HSA-9764561	6.951766e-01	0.158
MET activates PTK2 signaling	R-HSA-8874081	6.956364e-01	0.158
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	6.956364e-01	0.158
Metalloprotease DUBs	R-HSA-5689901	6.956364e-01	0.158
TRP channels	R-HSA-3295583	6.956364e-01	0.158
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	6.956364e-01	0.158
Suppression of phagosomal maturation	R-HSA-9637687	6.956364e-01	0.158
Regulation of T cell activation by CD28 family	R-HSA-388841	6.966438e-01	0.157
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	6.981004e-01	0.156
Dual incision in TC-NER	R-HSA-6782135	7.031220e-01	0.153
RNA Polymerase I Transcription Termination	R-HSA-73863	7.067540e-01	0.151
Packaging Of Telomere Ends	R-HSA-171306	7.067540e-01	0.151
EPHA-mediated growth cone collapse	R-HSA-3928663	7.067540e-01	0.151
Cristae formation	R-HSA-8949613	7.067540e-01	0.151
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	7.067540e-01	0.151
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	7.067540e-01	0.151
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.067540e-01	0.151
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.067540e-01	0.151
Regulation of beta-cell development	R-HSA-186712	7.108944e-01	0.148
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	7.108944e-01	0.148
Downstream TCR signaling	R-HSA-202424	7.114453e-01	0.148
Base Excision Repair	R-HSA-73884	7.114453e-01	0.148
Developmental Biology	R-HSA-1266738	7.127982e-01	0.147
Mitochondrial biogenesis	R-HSA-1592230	7.166086e-01	0.145
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	7.173165e-01	0.144
Telomere Extension By Telomerase	R-HSA-171319	7.174661e-01	0.144
Insulin receptor recycling	R-HSA-77387	7.174661e-01	0.144
Inflammasomes	R-HSA-622312	7.174661e-01	0.144
Negative regulation of FGFR3 signaling	R-HSA-5654732	7.174661e-01	0.144
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	7.174661e-01	0.144
Pyrimidine salvage	R-HSA-73614	7.174661e-01	0.144
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	7.174661e-01	0.144
G alpha (i) signalling events	R-HSA-418594	7.200316e-01	0.143
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	7.217274e-01	0.142
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.259284e-01	0.139
Nucleotide salvage	R-HSA-8956321	7.259284e-01	0.139
Transcriptional regulation by RUNX2	R-HSA-8878166	7.274742e-01	0.138
Impaired BRCA2 binding to RAD51	R-HSA-9709570	7.277875e-01	0.138
Signaling by CSF3 (G-CSF)	R-HSA-9674555	7.277875e-01	0.138
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	7.277875e-01	0.138
DNA methylation	R-HSA-5334118	7.277875e-01	0.138
Regulation of gene expression in beta cells	R-HSA-210745	7.277875e-01	0.138
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	7.277875e-01	0.138
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.277875e-01	0.138
Transcriptional regulation of granulopoiesis	R-HSA-9616222	7.331943e-01	0.135
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.331943e-01	0.135
NCAM signaling for neurite out-growth	R-HSA-375165	7.331943e-01	0.135
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	7.377325e-01	0.132
Activation of the pre-replicative complex	R-HSA-68962	7.377325e-01	0.132
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	7.377325e-01	0.132
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	7.377325e-01	0.132
Activation of BH3-only proteins	R-HSA-114452	7.377325e-01	0.132
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.377325e-01	0.132
Neurotransmitter clearance	R-HSA-112311	7.377325e-01	0.132
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	7.377325e-01	0.132
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	7.377859e-01	0.132
Xenobiotics	R-HSA-211981	7.472353e-01	0.127
Cargo concentration in the ER	R-HSA-5694530	7.473148e-01	0.126
Evasion by RSV of host interferon responses	R-HSA-9833109	7.473148e-01	0.126
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	7.473148e-01	0.126
Molecules associated with elastic fibres	R-HSA-2129379	7.473148e-01	0.126
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.477193e-01	0.126
Maternal to zygotic transition (MZT)	R-HSA-9816359	7.482670e-01	0.126
Innate Immune System	R-HSA-168249	7.494416e-01	0.125
Formation of the cornified envelope	R-HSA-6809371	7.532714e-01	0.123
Extracellular matrix organization	R-HSA-1474244	7.541361e-01	0.123
Inwardly rectifying K+ channels	R-HSA-1296065	7.565475e-01	0.121
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	7.565475e-01	0.121
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	7.565475e-01	0.121
Potassium Channels	R-HSA-1296071	7.589709e-01	0.120
Signaling by TGF-beta Receptor Complex	R-HSA-170834	7.644430e-01	0.117
Defective B3GALTL causes PpS	R-HSA-5083635	7.654434e-01	0.116
Keratan sulfate biosynthesis	R-HSA-2022854	7.654434e-01	0.116
Integrin signaling	R-HSA-354192	7.654434e-01	0.116
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	7.654434e-01	0.116
Activation of ATR in response to replication stress	R-HSA-176187	7.654434e-01	0.116
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	7.654434e-01	0.116
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.654434e-01	0.116
Regulation of necroptotic cell death	R-HSA-5675482	7.654434e-01	0.116
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	7.654434e-01	0.116
Cardiogenesis	R-HSA-9733709	7.654434e-01	0.116
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	7.654434e-01	0.116
HDR through Homologous Recombination (HRR)	R-HSA-5685942	7.671048e-01	0.115
Transcription of the HIV genome	R-HSA-167172	7.734199e-01	0.112
Resolution of D-Loop Structures	R-HSA-5693537	7.740147e-01	0.111
Acyl chain remodelling of PC	R-HSA-1482788	7.740147e-01	0.111
DNA Damage Recognition in GG-NER	R-HSA-5696394	7.740147e-01	0.111
Vpu mediated degradation of CD4	R-HSA-180534	7.740147e-01	0.111
Effects of PIP2 hydrolysis	R-HSA-114508	7.740147e-01	0.111
Heme degradation	R-HSA-189483	7.740147e-01	0.111
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.740147e-01	0.111
FOXO-mediated transcription	R-HSA-9614085	7.750844e-01	0.111
ABC-family proteins mediated transport	R-HSA-382556	7.802556e-01	0.108
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	7.822734e-01	0.107
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.822734e-01	0.107
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.822734e-01	0.107
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	7.822734e-01	0.107
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.822734e-01	0.107
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.822734e-01	0.107
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.822734e-01	0.107
Hyaluronan metabolism	R-HSA-2142845	7.822734e-01	0.107
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	7.822734e-01	0.107
COPII-mediated vesicle transport	R-HSA-204005	7.856027e-01	0.105
Cyclin E associated events during G1/S transition	R-HSA-69202	7.856027e-01	0.105
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	7.902307e-01	0.102
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	7.902307e-01	0.102
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	7.902307e-01	0.102
Acyl chain remodelling of PE	R-HSA-1482839	7.902307e-01	0.102
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	7.914755e-01	0.102
NoRC negatively regulates rRNA expression	R-HSA-427413	7.914755e-01	0.102
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	7.914755e-01	0.102
Regulation of mitotic cell cycle	R-HSA-453276	7.914755e-01	0.102
Hedgehog 'on' state	R-HSA-5632684	7.914755e-01	0.102
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	7.914755e-01	0.102
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.972059e-01	0.098
Purine catabolism	R-HSA-74259	7.972059e-01	0.098
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.972059e-01	0.098
G1/S-Specific Transcription	R-HSA-69205	7.978977e-01	0.098
PRC2 methylates histones and DNA	R-HSA-212300	7.978977e-01	0.098
Lysosome Vesicle Biogenesis	R-HSA-432720	7.978977e-01	0.098
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	7.978977e-01	0.098
Vif-mediated degradation of APOBEC3G	R-HSA-180585	7.978977e-01	0.098
HSF1 activation	R-HSA-3371511	7.978977e-01	0.098
Adaptive Immune System	R-HSA-1280218	7.983622e-01	0.098
Circadian clock	R-HSA-9909396	7.991675e-01	0.097
Switching of origins to a post-replicative state	R-HSA-69052	8.027966e-01	0.095
Aspirin ADME	R-HSA-9749641	8.027966e-01	0.095
Diseases of carbohydrate metabolism	R-HSA-5663084	8.027966e-01	0.095
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	8.052849e-01	0.094
Voltage gated Potassium channels	R-HSA-1296072	8.052849e-01	0.094
Degradation of DVL	R-HSA-4641258	8.052849e-01	0.094
Cleavage of the damaged purine	R-HSA-110331	8.052849e-01	0.094
SLC-mediated transport of organic cations	R-HSA-549127	8.052849e-01	0.094
Ovarian tumor domain proteases	R-HSA-5689896	8.052849e-01	0.094
RNA Polymerase II Pre-transcription Events	R-HSA-674695	8.082501e-01	0.092
Nucleotide Excision Repair	R-HSA-5696398	8.092567e-01	0.092
MET promotes cell motility	R-HSA-8875878	8.124025e-01	0.090
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.124025e-01	0.090
Depurination	R-HSA-73927	8.124025e-01	0.090
Purine salvage	R-HSA-74217	8.124025e-01	0.090
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.124025e-01	0.090
Elastic fibre formation	R-HSA-1566948	8.124025e-01	0.090
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.135688e-01	0.090
SARS-CoV-1-host interactions	R-HSA-9692914	8.137630e-01	0.090
SARS-CoV-2-host interactions	R-HSA-9705683	8.137691e-01	0.089
Synthesis of DNA	R-HSA-69239	8.181788e-01	0.087
Gene Silencing by RNA	R-HSA-211000	8.181788e-01	0.087
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.187555e-01	0.087
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.192604e-01	0.087
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.192604e-01	0.087
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	8.192604e-01	0.087
Stabilization of p53	R-HSA-69541	8.192604e-01	0.087
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	8.225053e-01	0.085
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	8.225053e-01	0.085
Stimuli-sensing channels	R-HSA-2672351	8.225053e-01	0.085
Translation of Structural Proteins	R-HSA-9694635	8.238125e-01	0.084
Developmental Cell Lineages	R-HSA-9734767	8.245963e-01	0.084
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	8.258679e-01	0.083
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	8.258679e-01	0.083
Attenuation phase	R-HSA-3371568	8.258679e-01	0.083
Interleukin-2 family signaling	R-HSA-451927	8.258679e-01	0.083
Formation of Incision Complex in GG-NER	R-HSA-5696395	8.258679e-01	0.083
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.258679e-01	0.083
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.258679e-01	0.083
Generation of second messenger molecules	R-HSA-202433	8.258679e-01	0.083
Glycogen metabolism	R-HSA-8982491	8.258679e-01	0.083
RNA Polymerase I Transcription	R-HSA-73864	8.287426e-01	0.082
Integrin cell surface interactions	R-HSA-216083	8.287426e-01	0.082
ABC transporter disorders	R-HSA-5619084	8.287426e-01	0.082
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.322343e-01	0.080
Hh mutants are degraded by ERAD	R-HSA-5362768	8.322343e-01	0.080
Transcriptional Regulation by VENTX	R-HSA-8853884	8.322343e-01	0.080
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.322343e-01	0.080
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.322343e-01	0.080
Regulation of PD-L1(CD274) expression	R-HSA-9909648	8.369355e-01	0.077
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.382316e-01	0.077
Degradation of CRY and PER proteins	R-HSA-9932298	8.383683e-01	0.077
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.383683e-01	0.077
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.383683e-01	0.077
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.383683e-01	0.077
FCERI mediated MAPK activation	R-HSA-2871796	8.389432e-01	0.076
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	8.440757e-01	0.074
GABA B receptor activation	R-HSA-977444	8.442784e-01	0.074
Activation of GABAB receptors	R-HSA-991365	8.442784e-01	0.074
RNA Polymerase I Transcription Initiation	R-HSA-73762	8.442784e-01	0.074
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.442784e-01	0.074
Incretin synthesis, secretion, and inactivation	R-HSA-400508	8.442784e-01	0.074
Defective pyroptosis	R-HSA-9710421	8.499727e-01	0.071
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.499727e-01	0.071
Response of Mtb to phagocytosis	R-HSA-9637690	8.499727e-01	0.071
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	8.499727e-01	0.071
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	8.515748e-01	0.070
Surfactant metabolism	R-HSA-5683826	8.554592e-01	0.068
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.554592e-01	0.068
RMTs methylate histone arginines	R-HSA-3214858	8.554592e-01	0.068
Interferon alpha/beta signaling	R-HSA-909733	8.576289e-01	0.067
Platelet Aggregation (Plug Formation)	R-HSA-76009	8.607453e-01	0.065
Fanconi Anemia Pathway	R-HSA-6783310	8.607453e-01	0.065
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	8.607453e-01	0.065
Defective CFTR causes cystic fibrosis	R-HSA-5678895	8.607453e-01	0.065
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.607453e-01	0.065
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.607453e-01	0.065
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.607453e-01	0.065
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	8.607453e-01	0.065
Cap-dependent Translation Initiation	R-HSA-72737	8.611302e-01	0.065
Eukaryotic Translation Initiation	R-HSA-72613	8.611302e-01	0.065
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.639083e-01	0.064
mRNA Splicing - Minor Pathway	R-HSA-72165	8.658384e-01	0.063
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	8.658384e-01	0.063
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.658384e-01	0.063
Regulation of pyruvate metabolism	R-HSA-9861718	8.658384e-01	0.063
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.658384e-01	0.063
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.658384e-01	0.063
Signaling by TGFBR3	R-HSA-9839373	8.658384e-01	0.063
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.678063e-01	0.062
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.707456e-01	0.060
Synthesis of PC	R-HSA-1483191	8.707456e-01	0.060
Keratan sulfate/keratin metabolism	R-HSA-1638074	8.800288e-01	0.056
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	8.800288e-01	0.056
p53-Dependent G1 DNA Damage Response	R-HSA-69563	8.800288e-01	0.056
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	8.814875e-01	0.055
Neurotransmitter release cycle	R-HSA-112310	8.823938e-01	0.054
Meiotic recombination	R-HSA-912446	8.886463e-01	0.051
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.886463e-01	0.051
Hedgehog ligand biogenesis	R-HSA-5358346	8.886463e-01	0.051
Branched-chain amino acid catabolism	R-HSA-70895	8.886463e-01	0.051
HCMV Late Events	R-HSA-9610379	8.893792e-01	0.051
Toll-like Receptor Cascades	R-HSA-168898	8.898093e-01	0.051
Disease	R-HSA-1643685	8.918589e-01	0.050
G1/S Transition	R-HSA-69206	8.921806e-01	0.050
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.923422e-01	0.049
mRNA 3'-end processing	R-HSA-72187	8.927205e-01	0.049
RNA Polymerase I Promoter Escape	R-HSA-73772	8.927205e-01	0.049
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	8.927205e-01	0.049
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.927205e-01	0.049
Assembly of the pre-replicative complex	R-HSA-68867	8.954809e-01	0.048
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	8.966458e-01	0.047
Amino acids regulate mTORC1	R-HSA-9639288	8.966458e-01	0.047
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.966458e-01	0.047
Signaling by TGFB family members	R-HSA-9006936	8.968079e-01	0.047
Collagen formation	R-HSA-1474290	8.985343e-01	0.046
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.004278e-01	0.046
G alpha (q) signalling events	R-HSA-416476	9.027537e-01	0.044
G alpha (z) signalling events	R-HSA-418597	9.040715e-01	0.044
HDACs deacetylate histones	R-HSA-3214815	9.040715e-01	0.044
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.043935e-01	0.044
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.072032e-01	0.042
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.075822e-01	0.042
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.075822e-01	0.042
TNF signaling	R-HSA-75893	9.075822e-01	0.042
Co-inhibition by PD-1	R-HSA-389948	9.092290e-01	0.041
Chromatin modifying enzymes	R-HSA-3247509	9.099090e-01	0.041
Adipogenesis	R-HSA-9843745	9.100577e-01	0.041
Degradation of the extracellular matrix	R-HSA-1474228	9.123800e-01	0.040
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.142233e-01	0.039
HATs acetylate histones	R-HSA-3214847	9.151757e-01	0.038
Cell surface interactions at the vascular wall	R-HSA-202733	9.152883e-01	0.038
GABA receptor activation	R-HSA-977443	9.203880e-01	0.036
Glutathione conjugation	R-HSA-156590	9.203880e-01	0.036
Metabolism of polyamines	R-HSA-351202	9.203880e-01	0.036
RNA Polymerase II Transcription Termination	R-HSA-73856	9.233024e-01	0.035
Endogenous sterols	R-HSA-211976	9.233024e-01	0.035
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.252052e-01	0.034
Mitochondrial protein import	R-HSA-1268020	9.261103e-01	0.033
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	9.261103e-01	0.033
Ribosome-associated quality control	R-HSA-9948299	9.271676e-01	0.033
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.288156e-01	0.032
G1/S DNA Damage Checkpoints	R-HSA-69615	9.288156e-01	0.032
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	9.292297e-01	0.032
Activation of HOX genes during differentiation	R-HSA-5619507	9.292297e-01	0.032
RSV-host interactions	R-HSA-9833110	9.292297e-01	0.032
SARS-CoV-2 Infection	R-HSA-9694516	9.305763e-01	0.031
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.309516e-01	0.031
Leishmania phagocytosis	R-HSA-9664417	9.309516e-01	0.031
Parasite infection	R-HSA-9664407	9.309516e-01	0.031
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.316252e-01	0.031
Cellular response to hypoxia	R-HSA-1234174	9.339331e-01	0.030
Chromatin organization	R-HSA-4839726	9.341050e-01	0.030
Transport of small molecules	R-HSA-382551	9.342639e-01	0.030
Influenza Infection	R-HSA-168255	9.360124e-01	0.029
Antigen processing-Cross presentation	R-HSA-1236975	9.373451e-01	0.028
Kidney development	R-HSA-9830369	9.386832e-01	0.027
DNA Replication Pre-Initiation	R-HSA-69002	9.392316e-01	0.027
Metabolism of RNA	R-HSA-8953854	9.396626e-01	0.027
Epigenetic regulation of gene expression	R-HSA-212165	9.400666e-01	0.027
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	9.409288e-01	0.026
Regulated Necrosis	R-HSA-5218859	9.409288e-01	0.026
Antimicrobial peptides	R-HSA-6803157	9.428442e-01	0.026
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	9.451768e-01	0.024
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.471849e-01	0.024
Metabolism of cofactors	R-HSA-8978934	9.471849e-01	0.024
Metabolism of porphyrins	R-HSA-189445	9.471849e-01	0.024
Potential therapeutics for SARS	R-HSA-9679191	9.487172e-01	0.023
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.514509e-01	0.022
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.514509e-01	0.022
Role of phospholipids in phagocytosis	R-HSA-2029485	9.524961e-01	0.021
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.524961e-01	0.021
DNA Replication	R-HSA-69306	9.527662e-01	0.021
ROS and RNS production in phagocytes	R-HSA-1222556	9.527795e-01	0.021
Citric acid cycle (TCA cycle)	R-HSA-71403	9.545096e-01	0.020
Iron uptake and transport	R-HSA-917937	9.545096e-01	0.020
Influenza Viral RNA Transcription and Replication	R-HSA-168273	9.552976e-01	0.020
UCH proteinases	R-HSA-5689603	9.561764e-01	0.019
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.577823e-01	0.019
Interleukin-10 signaling	R-HSA-6783783	9.593294e-01	0.018
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.608199e-01	0.017
GPCR downstream signalling	R-HSA-388396	9.614629e-01	0.017
Amyloid fiber formation	R-HSA-977225	9.636393e-01	0.016
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.636393e-01	0.016
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	9.649721e-01	0.015
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	9.662927e-01	0.015
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	9.662927e-01	0.015
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	9.662927e-01	0.015
Keratinization	R-HSA-6805567	9.684200e-01	0.014
Nucleotide catabolism	R-HSA-8956319	9.702814e-01	0.013
tRNA processing	R-HSA-72306	9.714263e-01	0.013
Post-translational protein modification	R-HSA-597592	9.717349e-01	0.012
Pyruvate metabolism	R-HSA-70268	9.720047e-01	0.012
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.730313e-01	0.012
ER-Phagosome pathway	R-HSA-1236974	9.740203e-01	0.011
SARS-CoV-1 Infection	R-HSA-9678108	9.752138e-01	0.011
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.758911e-01	0.011
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.776273e-01	0.010
Integration of energy metabolism	R-HSA-163685	9.776617e-01	0.010
FCGR activation	R-HSA-2029481	9.784480e-01	0.009
Mitochondrial protein degradation	R-HSA-9837999	9.792387e-01	0.009
Formation of a pool of free 40S subunits	R-HSA-72689	9.807342e-01	0.008
Diseases of glycosylation	R-HSA-3781865	9.808609e-01	0.008
SARS-CoV Infections	R-HSA-9679506	9.812643e-01	0.008
Mitochondrial translation elongation	R-HSA-5389840	9.814411e-01	0.008
Peptide ligand-binding receptors	R-HSA-375276	9.819373e-01	0.008
Mitochondrial translation initiation	R-HSA-5368286	9.827782e-01	0.008
Regulation of insulin secretion	R-HSA-422356	9.827782e-01	0.008
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.830576e-01	0.007
FCERI mediated NF-kB activation	R-HSA-2871837	9.832543e-01	0.007
Asparagine N-linked glycosylation	R-HSA-446203	9.839468e-01	0.007
Regulation of endogenous retroelements	R-HSA-9842860	9.851708e-01	0.006
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.857151e-01	0.006
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.862395e-01	0.006
Leishmania infection	R-HSA-9658195	9.872137e-01	0.006
Parasitic Infection Pathways	R-HSA-9824443	9.872137e-01	0.006
Protein localization	R-HSA-9609507	9.874776e-01	0.005
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.881519e-01	0.005
PPARA activates gene expression	R-HSA-1989781	9.882645e-01	0.005
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.890031e-01	0.005
Mitochondrial translation termination	R-HSA-5419276	9.890061e-01	0.005
Cellular response to starvation	R-HSA-9711097	9.893552e-01	0.005
Signaling by GPCR	R-HSA-372790	9.893782e-01	0.005
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.920672e-01	0.003
Peptide hormone metabolism	R-HSA-2980736	9.924386e-01	0.003
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.930436e-01	0.003
Drug ADME	R-HSA-9748784	9.931906e-01	0.003
G alpha (s) signalling events	R-HSA-418555	9.932687e-01	0.003
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.934904e-01	0.003
Diseases of metabolism	R-HSA-5668914	9.937509e-01	0.003
Neddylation	R-HSA-8951664	9.937793e-01	0.003
Translation	R-HSA-72766	9.940368e-01	0.003
Regulation of Complement cascade	R-HSA-977606	9.943962e-01	0.002
Viral Infection Pathways	R-HSA-9824446	9.944011e-01	0.002
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.948007e-01	0.002
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.958475e-01	0.002
Metabolism of nucleotides	R-HSA-15869	9.960572e-01	0.002
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.961653e-01	0.002
Glycosaminoglycan metabolism	R-HSA-1630316	9.967540e-01	0.001
O-linked glycosylation	R-HSA-5173105	9.968059e-01	0.001
Mitochondrial translation	R-HSA-5368287	9.969235e-01	0.001
Sphingolipid metabolism	R-HSA-428157	9.975164e-01	0.001
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.975434e-01	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	9.976776e-01	0.001
Complement cascade	R-HSA-166658	9.977210e-01	0.001
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.980953e-01	0.001
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.981108e-01	0.001
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.985473e-01	0.001
Phase I - Functionalization of compounds	R-HSA-211945	9.989331e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.990991e-01	0.000
rRNA processing	R-HSA-72312	9.991584e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.992329e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.992329e-01	0.000
Metabolism of proteins	R-HSA-392499	9.998177e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999103e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999341e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999385e-01	0.000
Infectious disease	R-HSA-5663205	9.999695e-01	0.000
GPCR ligand binding	R-HSA-500792	9.999715e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999732e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999810e-01	0.000
Biological oxidations	R-HSA-211859	9.999979e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955
Cell Cycle, Mitotic	R-HSA-69278	1.110223e-16	15.955
M Phase	R-HSA-68886	1.110223e-16	15.955
Axon guidance	R-HSA-422475	1.110223e-16	15.955
Nervous system development	R-HSA-9675108	1.110223e-16	15.955
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955
Cell-Cell communication	R-HSA-1500931	3.800738e-12	11.420
Mitotic Prometaphase	R-HSA-68877	4.611866e-12	11.336
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.317302e-12	11.274
Cellular response to heat stress	R-HSA-3371556	4.077827e-11	10.390
Signaling by ROBO receptors	R-HSA-376176	4.673661e-11	10.330
Cell Cycle Checkpoints	R-HSA-69620	5.399636e-11	10.268
Separation of Sister Chromatids	R-HSA-2467813	2.052094e-10	9.688
VEGFA-VEGFR2 Pathway	R-HSA-4420097	8.501826e-10	9.070
Mitotic Anaphase	R-HSA-68882	8.860738e-10	9.053
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.079801e-09	8.967
HSF1-dependent transactivation	R-HSA-3371571	1.505303e-09	8.822
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.739325e-09	8.760
Signal Transduction	R-HSA-162582	1.765996e-09	8.753
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.006930e-09	8.697
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.006930e-09	8.697
Post NMDA receptor activation events	R-HSA-438064	2.045322e-09	8.689
Cell junction organization	R-HSA-446728	2.082323e-09	8.681
Signaling by VEGF	R-HSA-194138	2.629471e-09	8.580
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	3.824796e-09	8.417
Metabolism of RNA	R-HSA-8953854	4.613625e-09	8.336
Translation initiation complex formation	R-HSA-72649	5.280984e-09	8.277
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	6.509764e-09	8.186
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	6.763814e-09	8.170
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	7.391944e-09	8.131
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.008011e-09	8.096
Cytokine Signaling in Immune system	R-HSA-1280215	8.944277e-09	8.048
Cap-dependent Translation Initiation	R-HSA-72737	1.677136e-08	7.775
Eukaryotic Translation Initiation	R-HSA-72613	1.677136e-08	7.775
Cell-cell junction organization	R-HSA-421270	1.610800e-08	7.793
L1CAM interactions	R-HSA-373760	1.677136e-08	7.775
Apoptotic execution phase	R-HSA-75153	2.291273e-08	7.640
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.999474e-08	7.523
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.218245e-08	7.492
Ribosomal scanning and start codon recognition	R-HSA-72702	3.604525e-08	7.443
Aggrephagy	R-HSA-9646399	4.417934e-08	7.355
Attenuation phase	R-HSA-3371568	4.417934e-08	7.355
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	4.438443e-08	7.353
Adherens junctions interactions	R-HSA-418990	4.460740e-08	7.351
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.438443e-08	7.353
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.519908e-08	7.345
Transcriptional regulation by RUNX1	R-HSA-8878171	4.641429e-08	7.333
G2/M Checkpoints	R-HSA-69481	5.564168e-08	7.255
Deubiquitination	R-HSA-5688426	5.920900e-08	7.228
Apoptosis	R-HSA-109581	1.596282e-07	6.797
Mitotic Prophase	R-HSA-68875	2.354558e-07	6.628
G2/M Transition	R-HSA-69275	2.381072e-07	6.623
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.506272e-07	6.601
MAPK family signaling cascades	R-HSA-5683057	2.643489e-07	6.578
HSF1 activation	R-HSA-3371511	3.110983e-07	6.507
Recycling pathway of L1	R-HSA-437239	3.442857e-07	6.463
Selective autophagy	R-HSA-9663891	3.449642e-07	6.462
Mitotic G2-G2/M phases	R-HSA-453274	3.386815e-07	6.470
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.247583e-07	6.372
Regulation of CDH1 Gene Transcription	R-HSA-9764560	4.651047e-07	6.332
Programmed Cell Death	R-HSA-5357801	5.057215e-07	6.296
EPH-Ephrin signaling	R-HSA-2682334	5.187054e-07	6.285
Developmental Biology	R-HSA-1266738	5.485082e-07	6.261
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	5.587717e-07	6.253
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	5.593326e-07	6.252
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.251675e-07	6.140
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	8.450234e-07	6.073
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.340900e-07	6.079
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.705295e-07	6.060
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.179045e-07	6.037
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.884114e-07	6.005
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	9.957831e-07	6.002
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.070511e-06	5.970
Membrane Trafficking	R-HSA-199991	1.171036e-06	5.931
Formation of a pool of free 40S subunits	R-HSA-72689	1.388814e-06	5.857
G2/M DNA damage checkpoint	R-HSA-69473	1.461835e-06	5.835
Signaling by Interleukins	R-HSA-449147	1.680424e-06	5.775
mRNA Splicing - Major Pathway	R-HSA-72163	1.777594e-06	5.750
HDACs deacetylate histones	R-HSA-3214815	1.830724e-06	5.737
Ribosome-associated quality control	R-HSA-9948299	1.838135e-06	5.736
Intracellular signaling by second messengers	R-HSA-9006925	1.953183e-06	5.709
Transcriptional regulation by small RNAs	R-HSA-5578749	2.132003e-06	5.671
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.133642e-06	5.671
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	2.275134e-06	5.643
Ub-specific processing proteases	R-HSA-5689880	2.750930e-06	5.561
Eukaryotic Translation Elongation	R-HSA-156842	2.884144e-06	5.540
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.124269e-06	5.505
Regulation of T cell activation by CD28 family	R-HSA-388841	4.367497e-06	5.360
Cellular Senescence	R-HSA-2559583	4.513143e-06	5.346
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.626061e-06	5.335
ISG15 antiviral mechanism	R-HSA-1169408	4.732312e-06	5.325
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	5.057952e-06	5.296
Signaling by ALK in cancer	R-HSA-9700206	5.057952e-06	5.296
mRNA Splicing	R-HSA-72172	5.214404e-06	5.283
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.562039e-06	5.255
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	6.014786e-06	5.221
Interleukin-12 signaling	R-HSA-9020591	6.108397e-06	5.214
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	6.121318e-06	5.213
Macroautophagy	R-HSA-1632852	6.431367e-06	5.192
Meiotic synapsis	R-HSA-1221632	7.302149e-06	5.137
Autophagy	R-HSA-9612973	6.929725e-06	5.159
Interferon Signaling	R-HSA-913531	7.457290e-06	5.127
Assembly of the pre-replicative complex	R-HSA-68867	8.220658e-06	5.085
SARS-CoV-2-host interactions	R-HSA-9705683	8.664653e-06	5.062
Regulation of CDH1 Function	R-HSA-9764561	8.960909e-06	5.048
MITF-M-dependent gene expression	R-HSA-9856651	9.429808e-06	5.025
MAPK6/MAPK4 signaling	R-HSA-5687128	9.819179e-06	5.008
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.003432e-05	4.999
Transport of connexons to the plasma membrane	R-HSA-190872	1.032645e-05	4.986
MITF-M-regulated melanocyte development	R-HSA-9730414	1.058638e-05	4.975
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.122951e-05	4.950
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.247900e-05	4.904
Nucleosome assembly	R-HSA-774815	1.247900e-05	4.904
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.189331e-05	4.925
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.259099e-05	4.900
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.404239e-05	4.853
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.506266e-05	4.822
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.506266e-05	4.822
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.776519e-05	4.750
SARS-CoV-1-host interactions	R-HSA-9692914	1.867982e-05	4.729
Interleukin-12 family signaling	R-HSA-447115	1.935563e-05	4.713
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.949767e-05	4.710
FLT3 Signaling	R-HSA-9607240	1.956639e-05	4.708
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.053061e-05	4.688
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.381429e-05	4.623
Peptide chain elongation	R-HSA-156902	2.406905e-05	4.619
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.550980e-05	4.593
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.751550e-05	4.560
Chromatin organization	R-HSA-4839726	2.601118e-05	4.585
Amplification of signal from the kinetochores	R-HSA-141424	2.770250e-05	4.557
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.770250e-05	4.557
Post-chaperonin tubulin folding pathway	R-HSA-389977	2.787657e-05	4.555
Nonsense-Mediated Decay (NMD)	R-HSA-927802	2.855260e-05	4.544
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	2.855260e-05	4.544
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.857684e-05	4.544
Striated Muscle Contraction	R-HSA-390522	3.166387e-05	4.499
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.058389e-05	4.515
Oxidative Stress Induced Senescence	R-HSA-2559580	3.058266e-05	4.515
Long-term potentiation	R-HSA-9620244	3.204805e-05	4.494
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.346407e-05	4.475
UCH proteinases	R-HSA-5689603	3.348039e-05	4.475
PIP3 activates AKT signaling	R-HSA-1257604	3.819312e-05	4.418
AURKA Activation by TPX2	R-HSA-8854518	3.915214e-05	4.407
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	4.439399e-05	4.353
Loss of Nlp from mitotic centrosomes	R-HSA-380259	4.439399e-05	4.353
Co-inhibition by PD-1	R-HSA-389948	4.586667e-05	4.339
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.890072e-05	4.311
Signaling by ERBB2	R-HSA-1227986	5.022145e-05	4.299
DNA Double Strand Break Response	R-HSA-5693606	4.984112e-05	4.302
Meiosis	R-HSA-1500620	4.905821e-05	4.309
Diseases of programmed cell death	R-HSA-9645723	5.230676e-05	4.281
NoRC negatively regulates rRNA expression	R-HSA-427413	5.517609e-05	4.258
Regulation of signaling by CBL	R-HSA-912631	6.344189e-05	4.198
EPHB-mediated forward signaling	R-HSA-3928662	6.678954e-05	4.175
DNA Replication Pre-Initiation	R-HSA-69002	6.703296e-05	4.174
Protein folding	R-HSA-391251	6.751772e-05	4.171
MAPK1/MAPK3 signaling	R-HSA-5684996	6.820149e-05	4.166
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	6.919536e-05	4.160
Packaging Of Telomere Ends	R-HSA-171306	7.012327e-05	4.154
RNA Polymerase I Promoter Opening	R-HSA-73728	7.012327e-05	4.154
Influenza Viral RNA Transcription and Replication	R-HSA-168273	7.242959e-05	4.140
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	7.983419e-05	4.098
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	7.981454e-05	4.098
PKR-mediated signaling	R-HSA-9833482	8.080994e-05	4.093
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	8.080994e-05	4.093
PECAM1 interactions	R-HSA-210990	8.392374e-05	4.076
rRNA processing in the nucleus and cytosol	R-HSA-8868773	8.457676e-05	4.073
COPI-mediated anterograde transport	R-HSA-6807878	8.543319e-05	4.068
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.622667e-05	4.064
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	8.657800e-05	4.063
Mitotic Spindle Checkpoint	R-HSA-69618	8.844446e-05	4.053
Chaperonin-mediated protein folding	R-HSA-390466	9.091795e-05	4.041
Signaling by Hippo	R-HSA-2028269	9.111817e-05	4.040
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.341987e-05	4.030
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.537239e-05	4.021
Oncogenic MAPK signaling	R-HSA-6802957	1.054552e-04	3.977
Processing of DNA double-strand break ends	R-HSA-5693607	9.961362e-05	4.002
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.041407e-04	3.982
Signaling by PTK6	R-HSA-8848021	1.041407e-04	3.982
Transcriptional regulation by RUNX3	R-HSA-8878159	1.030208e-04	3.987
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.078398e-04	3.967
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.078398e-04	3.967
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.272130e-04	3.895
Influenza Infection	R-HSA-168255	1.338265e-04	3.873
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.360906e-04	3.866
Ephrin signaling	R-HSA-3928664	1.434411e-04	3.843
Eukaryotic Translation Termination	R-HSA-72764	1.443495e-04	3.841
Neutrophil degranulation	R-HSA-6798695	1.723726e-04	3.764
DNA Double-Strand Break Repair	R-HSA-5693532	1.749326e-04	3.757
Meiotic recombination	R-HSA-912446	1.749963e-04	3.757
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.878632e-04	3.726
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.878632e-04	3.726
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.901278e-04	3.721
Signaling by RAF1 mutants	R-HSA-9656223	1.911191e-04	3.719
RAF/MAP kinase cascade	R-HSA-5673001	2.024420e-04	3.694
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.123771e-04	3.673
PTEN Regulation	R-HSA-6807070	2.128073e-04	3.672
TCF dependent signaling in response to WNT	R-HSA-201681	2.232801e-04	3.651
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.344343e-04	3.630
Semaphorin interactions	R-HSA-373755	2.365394e-04	3.626
Chromatin modifying enzymes	R-HSA-3247509	2.433577e-04	3.614
RNA Polymerase I Transcription	R-HSA-73864	2.459554e-04	3.609
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.561466e-04	3.592
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.697711e-04	3.569
Centrosome maturation	R-HSA-380287	2.858386e-04	3.544
Viral Infection Pathways	R-HSA-9824446	2.913353e-04	3.536
Host Interactions of HIV factors	R-HSA-162909	2.986654e-04	3.525
TCR signaling	R-HSA-202403	3.004136e-04	3.522
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.011424e-04	3.521
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.122794e-04	3.505
SIRT1 negatively regulates rRNA expression	R-HSA-427359	3.122794e-04	3.505
Nuclear Envelope Breakdown	R-HSA-2980766	3.133457e-04	3.504
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	3.140928e-04	3.503
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.293571e-04	3.482
ESR-mediated signaling	R-HSA-8939211	3.367791e-04	3.473
RNA Polymerase I Promoter Clearance	R-HSA-73854	3.481385e-04	3.458
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	3.494871e-04	3.457
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	3.957690e-04	3.403
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.653721e-04	3.437
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.622212e-04	3.441
SARS-CoV-2 Infection	R-HSA-9694516	3.718614e-04	3.430
PI3K/AKT Signaling in Cancer	R-HSA-2219528	4.085204e-04	3.389
Homology Directed Repair	R-HSA-5693538	4.085204e-04	3.389
DNA methylation	R-HSA-5334118	4.110804e-04	3.386
Immune System	R-HSA-168256	4.212660e-04	3.375
Interleukin-6 signaling	R-HSA-1059683	4.321632e-04	3.364
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	4.409994e-04	3.356
Estrogen-dependent gene expression	R-HSA-9018519	4.432660e-04	3.353
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.248559e-04	3.280
Regulation of TP53 Expression and Degradation	R-HSA-6806003	5.395421e-04	3.268
Downregulation of ERBB2 signaling	R-HSA-8863795	5.600415e-04	3.252
Degradation of CDH1	R-HSA-9766229	5.979255e-04	3.223
Gap junction trafficking and regulation	R-HSA-157858	5.979255e-04	3.223
Regulation of TP53 Degradation	R-HSA-6804757	6.064915e-04	3.217
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	6.182786e-04	3.209
Neurodegenerative Diseases	R-HSA-8863678	6.544204e-04	3.184
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	6.544204e-04	3.184
Gene Silencing by RNA	R-HSA-211000	6.582751e-04	3.182
SARS-CoV-1 Infection	R-HSA-9678108	6.623596e-04	3.179
RUNX3 regulates WNT signaling	R-HSA-8951430	6.714070e-04	3.173
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	6.912791e-04	3.160
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	6.912791e-04	3.160
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	6.912791e-04	3.160
Condensation of Prophase Chromosomes	R-HSA-2299718	6.862007e-04	3.164
Signaling by RAS mutants	R-HSA-6802949	6.862007e-04	3.164
Signaling downstream of RAS mutants	R-HSA-9649948	6.862007e-04	3.164
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	6.862007e-04	3.164
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	6.862007e-04	3.164
Golgi-to-ER retrograde transport	R-HSA-8856688	6.929542e-04	3.159
Regulation of TP53 Activity	R-HSA-5633007	7.498422e-04	3.125
HIV Infection	R-HSA-162906	7.365395e-04	3.133
Selenocysteine synthesis	R-HSA-2408557	7.734075e-04	3.112
Signaling by SCF-KIT	R-HSA-1433557	7.859502e-04	3.105
Cleavage of the damaged purine	R-HSA-110331	7.916105e-04	3.101
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.096793e-04	3.092
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	8.602649e-04	3.065
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.980780e-04	3.047
Regulation of endogenous retroelements	R-HSA-9842860	9.024298e-04	3.045
Gap junction trafficking	R-HSA-190828	9.958544e-04	3.002
Depurination	R-HSA-73927	1.023296e-03	2.990
Nephrin family interactions	R-HSA-373753	1.027799e-03	2.988
Viral mRNA Translation	R-HSA-192823	1.050000e-03	2.979
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.056265e-03	2.976
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.056265e-03	2.976
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	1.061105e-03	2.974
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.161966e-03	2.935
mRNA 3'-end processing	R-HSA-72187	1.162002e-03	2.935
RNA Polymerase I Promoter Escape	R-HSA-73772	1.162002e-03	2.935
Downregulation of ERBB4 signaling	R-HSA-1253288	1.226139e-03	2.911
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.226139e-03	2.911
Myogenesis	R-HSA-525793	1.230958e-03	2.910
Metalloprotease DUBs	R-HSA-5689901	1.230958e-03	2.910
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.313862e-03	2.881
S Phase	R-HSA-69242	1.372775e-03	2.862
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.406449e-03	2.852
Regulation of PTEN stability and activity	R-HSA-8948751	1.431602e-03	2.844
Cleavage of the damaged pyrimidine	R-HSA-110329	1.444646e-03	2.840
Depyrimidination	R-HSA-73928	1.444646e-03	2.840
Transcriptional Regulation by MECP2	R-HSA-8986944	1.457399e-03	2.836
PRC2 methylates histones and DNA	R-HSA-212300	1.497940e-03	2.825
Chaperone Mediated Autophagy	R-HSA-9613829	1.531233e-03	2.815
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.558925e-03	2.807
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.558925e-03	2.807
EPHA-mediated growth cone collapse	R-HSA-3928663	1.651263e-03	2.782
Regulation of RAS by GAPs	R-HSA-5658442	1.665796e-03	2.778
SARS-CoV Infections	R-HSA-9679506	1.721864e-03	2.764
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	2.004260e-03	2.698
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	2.094676e-03	2.679
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	1.937394e-03	2.713
Chromosome Maintenance	R-HSA-73886	1.959150e-03	2.708
Transcriptional Regulation by VENTX	R-HSA-8853884	2.094676e-03	2.679
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.829403e-03	2.738
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.796783e-03	2.746
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.094676e-03	2.679
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.829403e-03	2.738
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.884431e-03	2.725
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.193232e-03	2.659
FLT3 signaling by CBL mutants	R-HSA-9706377	2.196313e-03	2.658
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	2.286611e-03	2.641
Muscle contraction	R-HSA-397014	2.302798e-03	2.638
Signaling by WNT	R-HSA-195721	2.316573e-03	2.635
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.379585e-03	2.623
ATP-dependent chromatin remodelers	R-HSA-9932444	2.450343e-03	2.611
SWI/SNF chromatin remodelers	R-HSA-9932451	2.450343e-03	2.611
HCMV Early Events	R-HSA-9609690	2.483067e-03	2.605
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.524832e-03	2.598
Signaling by EGFR	R-HSA-177929	2.583654e-03	2.588
Degradation of GLI2 by the proteasome	R-HSA-5610783	2.615716e-03	2.582
Kinesins	R-HSA-983189	2.652368e-03	2.576
mTORC1-mediated signalling	R-HSA-166208	2.724047e-03	2.565
Signalling to ERKs	R-HSA-187687	2.791086e-03	2.554
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.855200e-03	2.544
Regulation of PTEN localization	R-HSA-8948747	2.993421e-03	2.524
Cohesin Loading onto Chromatin	R-HSA-2470946	2.993421e-03	2.524
Transcriptional Regulation by TP53	R-HSA-3700989	3.179038e-03	2.498
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.211949e-03	2.493
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.391190e-03	2.470
Folding of actin by CCT/TriC	R-HSA-390450	3.391190e-03	2.470
Clathrin-mediated endocytosis	R-HSA-8856828	3.410571e-03	2.467
HATs acetylate histones	R-HSA-3214847	3.446786e-03	2.463
Regulation of IFNG signaling	R-HSA-877312	3.500304e-03	2.456
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	3.500304e-03	2.456
RET signaling	R-HSA-8853659	3.518515e-03	2.454
GPVI-mediated activation cascade	R-HSA-114604	3.518515e-03	2.454
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	3.642370e-03	2.439
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.685980e-03	2.433
Gene expression (Transcription)	R-HSA-74160	3.720422e-03	2.429
HIV Life Cycle	R-HSA-162587	3.762625e-03	2.425
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.775794e-03	2.423
Cyclin E associated events during G1/S transition	R-HSA-69202	3.814621e-03	2.419
DNA Replication	R-HSA-69306	3.917238e-03	2.407
Hedgehog 'off' state	R-HSA-5610787	3.942310e-03	2.404
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.036033e-03	2.394
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.065257e-03	2.391
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.065257e-03	2.391
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	4.796822e-03	2.319
Downstream signal transduction	R-HSA-186763	4.704793e-03	2.327
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	4.704793e-03	2.327
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	4.704793e-03	2.327
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	4.704793e-03	2.327
Vpr-mediated nuclear import of PICs	R-HSA-180910	4.395793e-03	2.357
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.659435e-03	2.332
snRNP Assembly	R-HSA-191859	4.438128e-03	2.353
Metabolism of non-coding RNA	R-HSA-194441	4.438128e-03	2.353
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.659435e-03	2.332
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.987103e-03	2.302
Cilium Assembly	R-HSA-5617833	5.018004e-03	2.299
RAF activation	R-HSA-5673000	5.113259e-03	2.291
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	5.113259e-03	2.291
Nuclear import of Rev protein	R-HSA-180746	5.113259e-03	2.291
Gap junction assembly	R-HSA-190861	5.113259e-03	2.291
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	5.142657e-03	2.289
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.234021e-03	2.281
Regulation of PTEN gene transcription	R-HSA-8943724	5.261398e-03	2.279
FLT3 signaling through SRC family kinases	R-HSA-9706374	5.660490e-03	2.247
Degradation of GLI1 by the proteasome	R-HSA-5610780	5.706201e-03	2.244
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	5.706201e-03	2.244
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	5.904479e-03	2.229
G1/S Transition	R-HSA-69206	5.972566e-03	2.224
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.021197e-03	2.220
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.047014e-03	2.218
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.047014e-03	2.218
Translesion Synthesis by POLH	R-HSA-110320	6.082598e-03	2.216
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	6.140785e-03	2.212
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	6.140785e-03	2.212
Smooth Muscle Contraction	R-HSA-445355	6.140785e-03	2.212
RNA Polymerase II Transcription Termination	R-HSA-73856	6.207334e-03	2.207
VEGFR2 mediated cell proliferation	R-HSA-5218921	6.228259e-03	2.206
Platelet activation, signaling and aggregation	R-HSA-76002	6.317612e-03	2.199
Oncogene Induced Senescence	R-HSA-2559585	6.360589e-03	2.197
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	6.360589e-03	2.197
Cellular response to starvation	R-HSA-9711097	6.515221e-03	2.186
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.572210e-03	2.182
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	6.595899e-03	2.181
Stabilization of p53	R-HSA-69541	6.689321e-03	2.175
NS1 Mediated Effects on Host Pathways	R-HSA-168276	6.689321e-03	2.175
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	6.892681e-03	2.162
MTOR signalling	R-HSA-165159	6.937271e-03	2.159
Signaling by KIT in disease	R-HSA-9669938	7.123313e-03	2.147
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.123313e-03	2.147
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.123313e-03	2.147
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.155705e-03	2.145
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	7.289118e-03	2.137
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	7.292560e-03	2.137
Base-Excision Repair, AP Site Formation	R-HSA-73929	7.292560e-03	2.137
Nef and signal transduction	R-HSA-164944	7.293992e-03	2.137
Regulation of KIT signaling	R-HSA-1433559	7.330273e-03	2.135
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	7.330273e-03	2.135
CRMPs in Sema3A signaling	R-HSA-399956	7.330273e-03	2.135
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	7.426598e-03	2.129
IPs transport between nucleus and cytosol	R-HSA-1855170	7.426598e-03	2.129
Epigenetic regulation of gene expression	R-HSA-212165	7.436232e-03	2.129
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	7.608600e-03	2.119
Vesicle-mediated transport	R-HSA-5653656	7.727988e-03	2.112
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	7.758111e-03	2.110
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	7.758111e-03	2.110
Mitotic Telophase/Cytokinesis	R-HSA-68884	7.758111e-03	2.110
FLT3 signaling in disease	R-HSA-9682385	7.842491e-03	2.106
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	7.844071e-03	2.105
Telomere Maintenance	R-HSA-157579	7.928358e-03	2.101
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	8.098265e-03	2.092
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	9.194589e-03	2.036
Ovarian tumor domain proteases	R-HSA-5689896	9.588511e-03	2.018
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	9.588511e-03	2.018
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.614616e-03	2.065
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.015988e-02	1.993
Orc1 removal from chromatin	R-HSA-68949	1.015988e-02	1.993
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.012436e-02	1.995
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	8.294501e-03	2.081
Regulation of mitotic cell cycle	R-HSA-453276	8.294501e-03	2.081
Protein ubiquitination	R-HSA-8852135	8.145980e-03	2.089
Degradation of DVL	R-HSA-4641258	9.588511e-03	2.018
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	1.004317e-02	1.998
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.154123e-03	2.089
ER to Golgi Anterograde Transport	R-HSA-199977	8.199347e-03	2.086
DNA Repair	R-HSA-73894	9.574123e-03	2.019
G1/S DNA Damage Checkpoints	R-HSA-69615	8.520628e-03	2.070
Interactions of Rev with host cellular proteins	R-HSA-177243	8.154123e-03	2.089
rRNA processing	R-HSA-72312	8.762774e-03	2.057
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.294501e-03	2.081
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.004317e-02	1.998
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	9.194589e-03	2.036
Nuclear events mediated by NFE2L2	R-HSA-9759194	8.985691e-03	2.046
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	1.016366e-02	1.993
p75NTR signals via NF-kB	R-HSA-193639	1.016366e-02	1.993
Activation of BAD and translocation to mitochondria	R-HSA-111447	1.016366e-02	1.993
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.016366e-02	1.993
Amyloid fiber formation	R-HSA-977225	1.046676e-02	1.980
Switching of origins to a post-replicative state	R-HSA-69052	1.101722e-02	1.958
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.110236e-02	1.955
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.115314e-02	1.953
Mitophagy	R-HSA-5205647	1.128004e-02	1.948
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	1.128004e-02	1.948
Cellular response to chemical stress	R-HSA-9711123	1.130398e-02	1.947
Glycolysis	R-HSA-70171	1.136299e-02	1.945
Transcriptional regulation by RUNX2	R-HSA-8878166	1.159339e-02	1.936
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.162947e-02	1.934
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.175704e-02	1.930
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.175704e-02	1.930
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.178003e-02	1.929
Cation-coupled Chloride cotransporters	R-HSA-426117	1.178003e-02	1.929
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.178003e-02	1.929
Signaling by FGFR1 in disease	R-HSA-5655302	1.185111e-02	1.926
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.196605e-02	1.922
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.196605e-02	1.922
Late Phase of HIV Life Cycle	R-HSA-162599	1.198918e-02	1.921
Interferon alpha/beta signaling	R-HSA-909733	1.209316e-02	1.917
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.295514e-02	1.888
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.324896e-02	1.878
Signaling by PDGFR in disease	R-HSA-9671555	1.364851e-02	1.865
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.364851e-02	1.865
Regulation of Apoptosis	R-HSA-169911	1.371905e-02	1.863
Negative regulation of FLT3	R-HSA-9706369	1.375089e-02	1.862
Prolonged ERK activation events	R-HSA-169893	1.375089e-02	1.862
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	1.399718e-02	1.854
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.416899e-02	1.849
Late endosomal microautophagy	R-HSA-9615710	1.562995e-02	1.806
Vif-mediated degradation of APOBEC3G	R-HSA-180585	1.654845e-02	1.781
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.667782e-02	1.778
Generation of second messenger molecules	R-HSA-202433	1.672409e-02	1.777
Regulation of RUNX3 expression and activity	R-HSA-8941858	1.672409e-02	1.777
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.675793e-02	1.776
Defective pyroptosis	R-HSA-9710421	1.675793e-02	1.776
ChREBP activates metabolic gene expression	R-HSA-163765	1.691484e-02	1.772
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	1.771101e-02	1.752
Response of endothelial cells to shear stress	R-HSA-9860931	1.773656e-02	1.751
RNA Polymerase II Transcription	R-HSA-73857	1.789871e-02	1.747
Formation of annular gap junctions	R-HSA-196025	1.792417e-02	1.747
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.819808e-02	1.740
Signaling by EGFR in Cancer	R-HSA-1643713	1.840781e-02	1.735
Ion homeostasis	R-HSA-5578775	1.883714e-02	1.725
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.913980e-02	1.718
DAP12 signaling	R-HSA-2424491	1.913980e-02	1.718
Activation of BH3-only proteins	R-HSA-114452	1.913980e-02	1.718
Translation	R-HSA-72766	1.918737e-02	1.717
Co-stimulation by CD28	R-HSA-389356	1.951868e-02	1.710
Vpu mediated degradation of CD4	R-HSA-180534	1.958653e-02	1.708
Interleukin-1 family signaling	R-HSA-446652	1.962673e-02	1.707
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.970899e-02	1.705
Activation of HOX genes during differentiation	R-HSA-5619507	1.970899e-02	1.705
RMTs methylate histone arginines	R-HSA-3214858	1.973724e-02	1.705
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.980535e-02	1.703
Formation of definitive endoderm	R-HSA-9823730	2.024490e-02	1.694
Signal transduction by L1	R-HSA-445144	2.024490e-02	1.694
Organelle biogenesis and maintenance	R-HSA-1852241	2.058941e-02	1.686
Circadian clock	R-HSA-9909396	2.097773e-02	1.678
Adaptive Immune System	R-HSA-1280218	2.181125e-02	1.661
Signaling by NOTCH4	R-HSA-9013694	2.182818e-02	1.661
Cellular responses to mechanical stimuli	R-HSA-9855142	2.202643e-02	1.657
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.247818e-02	1.648
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.657068e-02	1.576
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	2.657068e-02	1.576
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.657068e-02	1.576
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.753633e-02	1.560
Gap junction degradation	R-HSA-190873	2.596668e-02	1.586
MAPK1 (ERK2) activation	R-HSA-112411	2.596668e-02	1.586
ALK mutants bind TKIs	R-HSA-9700645	2.596668e-02	1.586
Activation of RAC1	R-HSA-428540	2.349365e-02	1.629
NF-kB is activated and signals survival	R-HSA-209560	2.349365e-02	1.629
Erythropoietin activates RAS	R-HSA-9027284	2.742334e-02	1.562
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.007457e-02	1.522
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.007457e-02	1.522
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.007457e-02	1.522
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.007457e-02	1.522
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.554183e-02	1.593
Deadenylation of mRNA	R-HSA-429947	2.680225e-02	1.572
Interaction between L1 and Ankyrins	R-HSA-445095	2.263809e-02	1.645
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.793551e-02	1.554
MAP2K and MAPK activation	R-HSA-5674135	2.338653e-02	1.631
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.888986e-02	1.539
G0 and Early G1	R-HSA-1538133	2.789160e-02	1.555
DNA Damage Bypass	R-HSA-73893	2.271779e-02	1.644
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.261585e-02	1.646
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.789160e-02	1.555
GP1b-IX-V activation signalling	R-HSA-430116	2.596668e-02	1.586
Synaptic adhesion-like molecules	R-HSA-8849932	3.007457e-02	1.522
DAG and IP3 signaling	R-HSA-1489509	2.310605e-02	1.636
Asymmetric localization of PCP proteins	R-HSA-4608870	2.310605e-02	1.636
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.560593e-02	1.592
Translesion synthesis by REV1	R-HSA-110312	2.742334e-02	1.562
Deadenylation-dependent mRNA decay	R-HSA-429914	2.847594e-02	1.546
Interleukin-6 family signaling	R-HSA-6783589	2.680225e-02	1.572
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.263809e-02	1.645
NOD1/2 Signaling Pathway	R-HSA-168638	2.348555e-02	1.629
Death Receptor Signaling	R-HSA-73887	2.321360e-02	1.634
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	2.793551e-02	1.554
Spry regulation of FGF signaling	R-HSA-1295596	2.742334e-02	1.562
Signaling by NOTCH	R-HSA-157118	3.000338e-02	1.523
Cell-extracellular matrix interactions	R-HSA-446353	2.742334e-02	1.562
Reproduction	R-HSA-1474165	2.633487e-02	1.579
Activation of NF-kappaB in B cells	R-HSA-1169091	3.029431e-02	1.519
CLEC7A (Dectin-1) signaling	R-HSA-5607764	3.074503e-02	1.512
HCMV Infection	R-HSA-9609646	3.086235e-02	1.511
AKT phosphorylates targets in the cytosol	R-HSA-198323	3.164911e-02	1.500
Repression of WNT target genes	R-HSA-4641265	3.164911e-02	1.500
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	3.164911e-02	1.500
p75NTR recruits signalling complexes	R-HSA-209543	3.164911e-02	1.500
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.176491e-02	1.498
Beta-catenin independent WNT signaling	R-HSA-3858494	3.235849e-02	1.490
Sema4D in semaphorin signaling	R-HSA-400685	3.273947e-02	1.485
Signaling by Erythropoietin	R-HSA-9006335	3.318129e-02	1.479
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.318129e-02	1.479
FGFR1 mutant receptor activation	R-HSA-1839124	3.322636e-02	1.479
Regulation of necroptotic cell death	R-HSA-5675482	3.322636e-02	1.479
Regulation of MECP2 expression and activity	R-HSA-9022692	3.322636e-02	1.479
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.357063e-02	1.474
Intrinsic Pathway for Apoptosis	R-HSA-109606	3.357063e-02	1.474
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.359217e-02	1.474
Base Excision Repair	R-HSA-73884	3.377381e-02	1.471
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.392981e-02	1.469
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	3.472203e-02	1.459
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.482733e-02	1.458
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	3.537367e-02	1.451
Translesion synthesis by POLI	R-HSA-5656121	3.537367e-02	1.451
Negative regulation of the PI3K/AKT network	R-HSA-199418	3.579936e-02	1.446
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	3.610384e-02	1.442
Josephin domain DUBs	R-HSA-5689877	3.610384e-02	1.442
Pexophagy	R-HSA-9664873	3.610384e-02	1.442
MAPK3 (ERK1) activation	R-HSA-110056	3.610384e-02	1.442
Regulation of RUNX2 expression and activity	R-HSA-8939902	3.671115e-02	1.435
Cyclin D associated events in G1	R-HSA-69231	3.688221e-02	1.433
G1 Phase	R-HSA-69236	3.688221e-02	1.433
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.768486e-02	1.424
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	3.783345e-02	1.422
Hh mutants are degraded by ERAD	R-HSA-5362768	3.783345e-02	1.422
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.783345e-02	1.422
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.803291e-02	1.420
Degradation of AXIN	R-HSA-4641257	3.864460e-02	1.413
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.912725e-02	1.408
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.925792e-02	1.406
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	3.929565e-02	1.406
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	3.929565e-02	1.406
Neurophilin interactions with VEGF and VEGFR	R-HSA-194306	3.929565e-02	1.406
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	3.929565e-02	1.406
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	3.929565e-02	1.406
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	3.929565e-02	1.406
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	3.929565e-02	1.406
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	3.929565e-02	1.406
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	3.929565e-02	1.406
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	3.929565e-02	1.406
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	3.929565e-02	1.406
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	3.929565e-02	1.406
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.929565e-02	1.406
Golgi Associated Vesicle Biogenesis	R-HSA-432722	3.960804e-02	1.402
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	4.026952e-02	1.395
CD28 dependent Vav1 pathway	R-HSA-389359	4.150990e-02	1.382
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.150990e-02	1.382
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	4.243534e-02	1.372
Nectin/Necl trans heterodimerization	R-HSA-420597	4.273154e-02	1.369
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.273154e-02	1.369
Signaling by NTRKs	R-HSA-166520	4.330635e-02	1.363
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.460547e-02	1.351
Processing of Intronless Pre-mRNAs	R-HSA-77595	4.474955e-02	1.349
Translesion synthesis by POLK	R-HSA-5655862	4.474955e-02	1.349
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	4.474955e-02	1.349
Negative regulation of MET activity	R-HSA-6807004	4.651170e-02	1.332
EGFR downregulation	R-HSA-182971	4.683234e-02	1.329
Trafficking of AMPA receptors	R-HSA-399719	4.683234e-02	1.329
Budding and maturation of HIV virion	R-HSA-162588	4.683234e-02	1.329
Interleukin receptor SHC signaling	R-HSA-912526	4.725607e-02	1.326
Signaling by NTRK2 (TRKB)	R-HSA-9006115	4.729218e-02	1.325
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.729218e-02	1.325
CD28 dependent PI3K/Akt signaling	R-HSA-389357	4.729218e-02	1.325
trans-Golgi Network Vesicle Budding	R-HSA-199992	4.748492e-02	1.323
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	4.847896e-02	1.314
Interleukin-2 signaling	R-HSA-9020558	4.847896e-02	1.314
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	4.856105e-02	1.314
Interleukin-1 signaling	R-HSA-9020702	4.942880e-02	1.306
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	5.030596e-02	1.298
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	5.380924e-02	1.269
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	5.380924e-02	1.269
Diseases of Telomere Maintenance	R-HSA-9673013	5.380924e-02	1.269
UNC93B1 deficiency - HSE	R-HSA-5602415	5.380924e-02	1.269
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	5.380924e-02	1.269
TICAM1 deficiency - HSE	R-HSA-5602566	5.380924e-02	1.269
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	5.380924e-02	1.269
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	6.721554e-02	1.173
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	6.721554e-02	1.173
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	6.721554e-02	1.173
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	6.721554e-02	1.173
MET activates PTPN11	R-HSA-8865999	6.721554e-02	1.173
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	6.721554e-02	1.173
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	6.335220e-02	1.198
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	5.605530e-02	1.251
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	5.605530e-02	1.251
Signaling by MRAS-complex mutants	R-HSA-9660537	5.605530e-02	1.251
Myoclonic epilepsy of Lafora	R-HSA-3785653	5.605530e-02	1.251
MET receptor recycling	R-HSA-8875656	5.605530e-02	1.251
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	5.605530e-02	1.251
ARMS-mediated activation	R-HSA-170984	7.492754e-02	1.125
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.492754e-02	1.125
WNT mediated activation of DVL	R-HSA-201688	7.492754e-02	1.125
AKT phosphorylates targets in the nucleus	R-HSA-198693	7.492754e-02	1.125
Inactivation of CDC42 and RAC1	R-HSA-428543	7.492754e-02	1.125
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	6.317729e-02	1.199
Condensation of Prometaphase Chromosomes	R-HSA-2514853	6.317729e-02	1.199
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	6.669962e-02	1.176
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.669962e-02	1.176
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	6.669962e-02	1.176
p38MAPK events	R-HSA-171007	6.669962e-02	1.176
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.669962e-02	1.176
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.669962e-02	1.176
Signaling by EGFRvIII in Cancer	R-HSA-5637812	5.562397e-02	1.255
Constitutive Signaling by EGFRvIII	R-HSA-5637810	5.562397e-02	1.255
Signalling to RAS	R-HSA-167044	5.661402e-02	1.247
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	5.663387e-02	1.247
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	5.600158e-02	1.252
Tight junction interactions	R-HSA-420029	6.715448e-02	1.173
Diseases of mitotic cell cycle	R-HSA-9675126	5.492926e-02	1.260
Termination of translesion DNA synthesis	R-HSA-5656169	6.571522e-02	1.182
SHC1 events in ERBB2 signaling	R-HSA-1250196	7.645820e-02	1.117
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.231461e-02	1.141
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.231461e-02	1.141
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.231461e-02	1.141
Downstream TCR signaling	R-HSA-202424	5.262184e-02	1.279
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	6.391813e-02	1.194
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	6.823478e-02	1.166
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	5.479126e-02	1.261
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	7.105623e-02	1.148
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.356184e-02	1.271
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.804689e-02	1.167
ER-Phagosome pathway	R-HSA-1236974	7.283406e-02	1.138
TNF signaling	R-HSA-75893	5.723157e-02	1.242
Protein methylation	R-HSA-8876725	6.669962e-02	1.176
Activation of ATR in response to replication stress	R-HSA-176187	6.391813e-02	1.194
Rab regulation of trafficking	R-HSA-9007101	7.472815e-02	1.127
Integrin signaling	R-HSA-354192	6.391813e-02	1.194
PCP/CE pathway	R-HSA-4086400	5.564269e-02	1.255
Extra-nuclear estrogen signaling	R-HSA-9009391	7.333747e-02	1.135
Interleukin-2 family signaling	R-HSA-451927	5.974583e-02	1.224
PKMTs methylate histone lysines	R-HSA-3214841	6.823478e-02	1.166
DCC mediated attractive signaling	R-HSA-418885	6.669962e-02	1.176
CaM pathway	R-HSA-111997	6.189773e-02	1.208
Calmodulin induced events	R-HSA-111933	6.189773e-02	1.208
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.492754e-02	1.125
MyD88-independent TLR4 cascade	R-HSA-166166	5.299065e-02	1.276
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	5.299065e-02	1.276
Protein-protein interactions at synapses	R-HSA-6794362	7.029760e-02	1.153
TBC/RABGAPs	R-HSA-8854214	5.752607e-02	1.240
Synthesis of DNA	R-HSA-69239	6.071043e-02	1.217
Signaling by TGFB family members	R-HSA-9006936	7.173319e-02	1.144
Generic Transcription Pathway	R-HSA-212436	5.505632e-02	1.259
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	6.262197e-02	1.203
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.774117e-02	1.239
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	6.391813e-02	1.194
Degradation of CRY and PER proteins	R-HSA-9932298	7.748504e-02	1.111
Signaling by NTRK1 (TRKA)	R-HSA-187037	6.372515e-02	1.196
Signaling by FGFR in disease	R-HSA-1226099	5.852483e-02	1.233
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	6.391813e-02	1.194
Netrin-1 signaling	R-HSA-373752	6.541153e-02	1.184
Signaling by Hedgehog	R-HSA-5358351	5.446510e-02	1.264
ROBO receptors bind AKAP5	R-HSA-9010642	5.605530e-02	1.251
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.492754e-02	1.125
Hh mutants abrogate ligand secretion	R-HSA-5387390	5.752607e-02	1.240
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	5.770062e-02	1.239
Cellular response to hypoxia	R-HSA-1234174	5.822447e-02	1.235
Transcriptional Regulation by E2F6	R-HSA-8953750	5.200035e-02	1.284
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.217228e-02	1.283
Signal regulatory protein family interactions	R-HSA-391160	5.317282e-02	1.274
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.399056e-02	1.131
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.399056e-02	1.131
Glucose metabolism	R-HSA-70326	5.185736e-02	1.285
p75 NTR receptor-mediated signalling	R-HSA-193704	6.204735e-02	1.207
MHC class II antigen presentation	R-HSA-2132295	5.770062e-02	1.239
Selenoamino acid metabolism	R-HSA-2408522	6.814745e-02	1.167
Regulation of CDH19 Expression and Function	R-HSA-9764302	6.335220e-02	1.198
Maturation of protein E	R-HSA-9694493	6.335220e-02	1.198
Maturation of protein E	R-HSA-9683683	6.335220e-02	1.198
Interleukin-37 signaling	R-HSA-9008059	7.645820e-02	1.117
Regulated Necrosis	R-HSA-5218859	7.927317e-02	1.101
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	8.022463e-02	1.096
Regulation of IFNA/IFNB signaling	R-HSA-912694	8.079953e-02	1.093
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.079953e-02	1.093
RAF-independent MAPK1/3 activation	R-HSA-112409	8.079953e-02	1.093
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.105483e-02	1.091
STING mediated induction of host immune responses	R-HSA-1834941	8.204388e-02	1.086
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	8.211549e-02	1.086
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	8.211549e-02	1.086
Regulation of NF-kappa B signaling	R-HSA-9758274	8.211549e-02	1.086
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	8.264640e-02	1.083
mRNA Splicing - Minor Pathway	R-HSA-72165	8.327679e-02	1.079
Regulation of TNFR1 signaling	R-HSA-5357905	8.327679e-02	1.079
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	8.466162e-02	1.072
TP53 Regulates Metabolic Genes	R-HSA-5628897	8.490964e-02	1.071
Signaling by Nuclear Receptors	R-HSA-9006931	8.501302e-02	1.071
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	8.750923e-02	1.058
Ca-dependent events	R-HSA-111996	8.750923e-02	1.058
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.824560e-02	1.054
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.824560e-02	1.054
Evasion by RSV of host interferon responses	R-HSA-9833109	8.824560e-02	1.054
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	8.829128e-02	1.054
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.850008e-02	1.053
Hedgehog ligand biogenesis	R-HSA-5358346	8.850008e-02	1.053
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.171321e-02	1.038
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	9.190454e-02	1.037
Signaling by ALK	R-HSA-201556	9.190454e-02	1.037
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.327937e-02	1.030
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	9.491646e-02	1.023
MET activates RAP1 and RAC1	R-HSA-8875555	9.681677e-02	1.014
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	9.681677e-02	1.014
Receptor Mediated Mitophagy	R-HSA-8934903	9.681677e-02	1.014
Regulation of CDH11 function	R-HSA-9762292	9.681677e-02	1.014
Signaling by Leptin	R-HSA-2586552	9.681677e-02	1.014
Interleukin-27 signaling	R-HSA-9020956	9.681677e-02	1.014
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	9.761568e-02	1.010
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	9.761568e-02	1.010
Co-inhibition by CTLA4	R-HSA-389513	9.761568e-02	1.010
Signaling by FGFR4	R-HSA-5654743	9.831452e-02	1.007
GRB2 events in ERBB2 signaling	R-HSA-1963640	9.940913e-02	1.003
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.940913e-02	1.003
Disorders of Developmental Biology	R-HSA-9675151	9.940913e-02	1.003
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	9.958897e-02	1.002
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	9.958897e-02	1.002
Formation of axial mesoderm	R-HSA-9796292	9.958897e-02	1.002
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	9.958897e-02	1.002
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	9.958897e-02	1.002
Frs2-mediated activation	R-HSA-170968	9.958897e-02	1.002
Membrane binding and targetting of GAG proteins	R-HSA-174490	9.958897e-02	1.002
Regulation of gap junction activity	R-HSA-191650	1.018707e-01	0.992
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.018707e-01	0.992
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	1.018707e-01	0.992
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	1.018707e-01	0.992
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	1.018707e-01	0.992
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.020821e-01	0.991
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.030874e-01	0.987
Manipulation of host energy metabolism	R-HSA-9636667	1.075387e-01	0.968
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	1.075387e-01	0.968
TRAF3 deficiency - HSE	R-HSA-5602571	1.075387e-01	0.968
Breakdown of the nuclear lamina	R-HSA-352238	1.075387e-01	0.968
DAP12 interactions	R-HSA-2172127	1.099024e-01	0.959
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.110204e-01	0.955
Basigin interactions	R-HSA-210991	1.147385e-01	0.940
G-protein beta:gamma signalling	R-HSA-397795	1.149620e-01	0.939
Nuclear RNA decay	R-HSA-9930044	1.149620e-01	0.939
Activated NTRK3 signals through PI3K	R-HSA-9603381	1.172217e-01	0.931
IFNG signaling activates MAPKs	R-HSA-9732724	1.172217e-01	0.931
SOS-mediated signalling	R-HSA-112412	1.172217e-01	0.931
MECP2 regulates transcription factors	R-HSA-9022707	1.172217e-01	0.931
Uptake and function of diphtheria toxin	R-HSA-5336415	1.172217e-01	0.931
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.185341e-01	0.926
Regulation of gene expression in beta cells	R-HSA-210745	1.209774e-01	0.917
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.209774e-01	0.917
Signaling by FGFR4 in disease	R-HSA-5655291	1.211847e-01	0.917
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	1.211847e-01	0.917
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.211847e-01	0.917
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.211847e-01	0.917
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.211847e-01	0.917
NRIF signals cell death from the nucleus	R-HSA-205043	1.211847e-01	0.917
Non-canonical inflammasome activation	R-HSA-9686114	1.211847e-01	0.917
Somitogenesis	R-HSA-9824272	1.222688e-01	0.913
XBP1(S) activates chaperone genes	R-HSA-381038	1.227768e-01	0.911
Potential therapeutics for SARS	R-HSA-9679191	1.266972e-01	0.897
Negative regulation of MAPK pathway	R-HSA-5675221	1.295690e-01	0.887
Drug resistance of FLT3 mutants	R-HSA-9702506	1.691041e-01	0.772
Drug resistance of KIT mutants	R-HSA-9669937	1.691041e-01	0.772
Drug resistance of PDGFR mutants	R-HSA-9674415	1.691041e-01	0.772
KIT mutants bind TKIs	R-HSA-9669921	1.691041e-01	0.772
FLT3 mutants bind TKIs	R-HSA-9702509	1.691041e-01	0.772
PDGFR mutants bind TKIs	R-HSA-9674428	1.691041e-01	0.772
gilteritinib-resistant FLT3 mutants	R-HSA-9702590	1.691041e-01	0.772
Evasion of Oncogene Induced Senescence Due to p14ARF Defects	R-HSA-9646303	1.691041e-01	0.772
quizartinib-resistant FLT3 mutants	R-HSA-9702620	1.691041e-01	0.772
sorafenib-resistant FLT3 mutants	R-HSA-9702624	1.691041e-01	0.772
Imatinib-resistant KIT mutants	R-HSA-9669917	1.691041e-01	0.772
semaxanib-resistant FLT3 mutants	R-HSA-9702577	1.691041e-01	0.772
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.691041e-01	0.772
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.691041e-01	0.772
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.691041e-01	0.772
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.691041e-01	0.772
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.691041e-01	0.772
linifanib-resistant FLT3 mutants	R-HSA-9702998	1.691041e-01	0.772
pexidartinib-resistant FLT3 mutants	R-HSA-9702605	1.691041e-01	0.772
TLR3 deficiency - HSE	R-HSA-5602410	1.691041e-01	0.772
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.691041e-01	0.772
ponatinib-resistant FLT3 mutants	R-HSA-9702614	1.691041e-01	0.772
sunitinib-resistant FLT3 mutants	R-HSA-9702632	1.691041e-01	0.772
tandutinib-resistant FLT3 mutants	R-HSA-9702636	1.691041e-01	0.772
KW2449-resistant FLT3 mutants	R-HSA-9702569	1.691041e-01	0.772
crenolanib-resistant FLT3 mutants	R-HSA-9702581	1.691041e-01	0.772
midostaurin-resistant FLT3 mutants	R-HSA-9702600	1.691041e-01	0.772
tamatinib-resistant FLT3 mutants	R-HSA-9703009	1.691041e-01	0.772
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.691041e-01	0.772
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.691041e-01	0.772
Masitinib-resistant KIT mutants	R-HSA-9669924	1.691041e-01	0.772
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.691041e-01	0.772
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.691041e-01	0.772
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.691041e-01	0.772
lestaurtinib-resistant FLT3 mutants	R-HSA-9702596	1.691041e-01	0.772
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.691041e-01	0.772
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	R-HSA-9646304	1.691041e-01	0.772
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.691041e-01	0.772
Regulation of TP53 Expression	R-HSA-6804754	1.701565e-01	0.769
Diseases of Cellular Senescence	R-HSA-9630747	1.701565e-01	0.769
Diseases of cellular response to stress	R-HSA-9675132	1.701565e-01	0.769
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.701565e-01	0.769
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	1.701565e-01	0.769
Regulation of cortical dendrite branching	R-HSA-8985801	1.701565e-01	0.769
Signaling by RAS GAP mutants	R-HSA-9753510	1.701565e-01	0.769
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	1.701565e-01	0.769
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.420965e-01	0.847
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	1.420965e-01	0.847
Co-inhibition by BTLA	R-HSA-9927353	1.420965e-01	0.847
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.420965e-01	0.847
IRS activation	R-HSA-74713	1.420965e-01	0.847
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.420965e-01	0.847
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	1.420965e-01	0.847
STAT6-mediated induction of chemokines	R-HSA-3249367	2.371221e-01	0.625
Signaling by FGFR1 amplification mutants	R-HSA-1839120	2.371221e-01	0.625
TRKA activation by NGF	R-HSA-187042	2.371221e-01	0.625
PLC-gamma1 signalling	R-HSA-167021	2.371221e-01	0.625
Activated NTRK3 signals through PLCG1	R-HSA-9034793	2.371221e-01	0.625
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	2.371221e-01	0.625
MET interacts with TNS proteins	R-HSA-8875513	2.371221e-01	0.625
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.866064e-01	0.729
Phosphorylation of Emi1	R-HSA-176417	1.866064e-01	0.729
PTK6 Regulates Cell Cycle	R-HSA-8849470	1.866064e-01	0.729
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	1.866064e-01	0.729
Type I hemidesmosome assembly	R-HSA-446107	1.496813e-01	0.825
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	1.496813e-01	0.825
MASTL Facilitates Mitotic Progression	R-HSA-2465910	1.851196e-01	0.733
STAT5 Activation	R-HSA-9645135	2.341213e-01	0.631
Erythropoietin activates STAT5	R-HSA-9027283	2.341213e-01	0.631
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	2.341213e-01	0.631
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	1.448786e-01	0.839
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.448786e-01	0.839
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.786255e-01	0.748
2-LTR circle formation	R-HSA-164843	2.229395e-01	0.652
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	2.229395e-01	0.652
GAB1 signalosome	R-HSA-180292	1.394114e-01	0.856
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.333651e-01	0.875
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.103139e-01	0.677
IKK complex recruitment mediated by RIP1	R-HSA-937041	1.619328e-01	0.791
FGFR2 alternative splicing	R-HSA-6803529	1.534263e-01	0.814
G beta:gamma signalling through CDC42	R-HSA-8964616	1.978343e-01	0.704
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	1.978343e-01	0.704
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.978343e-01	0.704
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.978343e-01	0.704
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	1.978343e-01	0.704
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.373297e-01	0.862
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	2.436350e-01	0.613
PI3K events in ERBB2 signaling	R-HSA-1963642	2.266601e-01	0.645
Elevation of cytosolic Ca2+ levels	R-HSA-139853	2.266601e-01	0.645
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	2.113542e-01	0.675
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	2.113542e-01	0.675
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.113542e-01	0.675
Dual Incision in GG-NER	R-HSA-5696400	1.457766e-01	0.836
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.974805e-01	0.704
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.437975e-01	0.842
Signaling by NTRK3 (TRKC)	R-HSA-9034015	2.379301e-01	0.624
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	2.062837e-01	0.686
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.062837e-01	0.686
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.448898e-01	0.839
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	2.460015e-01	0.609
Signaling by ERBB4	R-HSA-1236394	1.350760e-01	0.869
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	2.343618e-01	0.630
Dual incision in TC-NER	R-HSA-6782135	1.719782e-01	0.765
Nuclear signaling by ERBB4	R-HSA-1251985	2.596165e-01	0.586
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	2.074860e-01	0.683
Nucleotide Excision Repair	R-HSA-5696398	2.012945e-01	0.696
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	1.920598e-01	0.717
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.402858e-01	0.853
Early Phase of HIV Life Cycle	R-HSA-162594	2.113542e-01	0.675
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.534263e-01	0.814
Signaling by MET	R-HSA-6806834	1.487167e-01	0.828
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.394114e-01	0.856
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.927532e-01	0.715
Interleukin-20 family signaling	R-HSA-8854691	1.748334e-01	0.757
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.379301e-01	0.624
C-type lectin receptors (CLRs)	R-HSA-5621481	1.431362e-01	0.844
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.619328e-01	0.791
Interleukin-35 Signalling	R-HSA-8984722	1.786255e-01	0.748
TGFBR3 expression	R-HSA-9839394	2.212472e-01	0.655
Platelet calcium homeostasis	R-HSA-418360	2.062837e-01	0.686
Signaling by FGFR1	R-HSA-5654736	1.448898e-01	0.839
PLC beta mediated events	R-HSA-112043	1.487567e-01	0.828
Integration of provirus	R-HSA-162592	1.489302e-01	0.827
EGFR Transactivation by Gastrin	R-HSA-2179392	2.229395e-01	0.652
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.927532e-01	0.715
IRS-related events triggered by IGF1R	R-HSA-2428928	2.170234e-01	0.663
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.911851e-01	0.719
G-protein mediated events	R-HSA-112040	1.647808e-01	0.783
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.496813e-01	0.825
PI3K/AKT activation	R-HSA-198203	2.229395e-01	0.652
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	1.492914e-01	0.826
PTK6 Activates STAT3	R-HSA-8849474	1.420965e-01	0.847
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	1.457766e-01	0.836
Proteasome assembly	R-HSA-9907900	2.620720e-01	0.582
Signaling by PDGF	R-HSA-186797	1.616827e-01	0.791
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	2.113542e-01	0.675
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.489093e-01	0.827
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.461698e-01	0.835
Signaling by FGFR	R-HSA-190236	1.669117e-01	0.778
CREB phosphorylation	R-HSA-199920	2.341213e-01	0.631
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.341213e-01	0.631
RUNX3 regulates p14-ARF	R-HSA-8951936	1.786255e-01	0.748
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.786255e-01	0.748
IRAK1 recruits IKK complex	R-HSA-937039	1.786255e-01	0.748
VLDLR internalisation and degradation	R-HSA-8866427	1.786255e-01	0.748
Apoptosis induced DNA fragmentation	R-HSA-140342	2.229395e-01	0.652
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.927532e-01	0.715
CASP4 inflammasome assembly	R-HSA-9948001	2.229395e-01	0.652
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.062837e-01	0.686
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.263305e-01	0.645
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.460015e-01	0.609
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.669117e-01	0.778
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.500768e-01	0.602
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.669117e-01	0.778
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.669117e-01	0.778
Neurexins and neuroligins	R-HSA-6794361	2.291055e-01	0.640
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	2.374297e-01	0.624
Antigen processing-Cross presentation	R-HSA-1236975	1.797193e-01	0.745
Transmission across Chemical Synapses	R-HSA-112315	1.563021e-01	0.806
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	2.371221e-01	0.625
CASP5-mediated substrate cleavage	R-HSA-9960525	2.371221e-01	0.625
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	2.113542e-01	0.675
G alpha (12/13) signalling events	R-HSA-416482	1.823971e-01	0.739
Neuronal System	R-HSA-112316	2.279698e-01	0.642
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.133393e-01	0.671
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.371272e-01	0.625
MAP kinase activation	R-HSA-450294	2.170234e-01	0.663
Heme signaling	R-HSA-9707616	2.331037e-01	0.632
Glycogen synthesis	R-HSA-3322077	1.859651e-01	0.731
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	2.331037e-01	0.632
Glycogen metabolism	R-HSA-8982491	2.596165e-01	0.586
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.451940e-01	0.838
Signaling by FGFR2	R-HSA-5654738	1.487167e-01	0.828
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	1.866064e-01	0.729
Hedgehog 'on' state	R-HSA-5632684	2.204844e-01	0.657
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.927532e-01	0.715
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.371272e-01	0.625
Rap1 signalling	R-HSA-392517	1.619328e-01	0.791
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	2.460015e-01	0.609
Signaling by FGFR3	R-HSA-5654741	1.911851e-01	0.719
Signaling by NOTCH3	R-HSA-9012852	1.986193e-01	0.702
Gastrulation	R-HSA-9758941	2.541458e-01	0.595
Hemostasis	R-HSA-109582	2.387725e-01	0.622
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	1.701565e-01	0.769
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	1.420965e-01	0.847
CASP4-mediated substrate cleavage	R-HSA-9960519	2.371221e-01	0.625
TRAIL signaling	R-HSA-75158	1.866064e-01	0.729
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.851196e-01	0.733
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	1.786255e-01	0.748
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	1.786255e-01	0.748
Glycogen storage diseases	R-HSA-3229121	2.266601e-01	0.645
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	1.457766e-01	0.836
Intraflagellar transport	R-HSA-5620924	1.639109e-01	0.785
Viral Messenger RNA Synthesis	R-HSA-168325	1.487567e-01	0.828
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	2.185581e-01	0.660
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.731855e-01	0.761
Formation of paraxial mesoderm	R-HSA-9793380	2.170234e-01	0.663
HCMV Late Events	R-HSA-9610379	1.420289e-01	0.848
Other interleukin signaling	R-HSA-449836	1.619328e-01	0.791
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.748334e-01	0.757
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.379301e-01	0.624
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.779493e-01	0.750
FasL/ CD95L signaling	R-HSA-75157	2.371221e-01	0.625
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	2.291055e-01	0.640
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.436350e-01	0.613
Infectious disease	R-HSA-5663205	2.485510e-01	0.605
Inositol phosphate metabolism	R-HSA-1483249	2.250318e-01	0.648
Platelet degranulation	R-HSA-114608	2.593470e-01	0.586
G1/S-Specific Transcription	R-HSA-69205	1.804401e-01	0.744
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	1.732749e-01	0.761
SLC-mediated transport of inorganic anions	R-HSA-9958790	2.185581e-01	0.660
Diseases of DNA repair	R-HSA-9675135	2.084313e-01	0.681
tRNA processing in the nucleus	R-HSA-6784531	1.616827e-01	0.791
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	2.387557e-01	0.622
Unfolded Protein Response (UPR)	R-HSA-381119	1.478235e-01	0.830
NrCAM interactions	R-HSA-447038	1.420965e-01	0.847
Assembly Of The HIV Virion	R-HSA-175474	2.379301e-01	0.624
IRE1alpha activates chaperones	R-HSA-381070	1.870190e-01	0.728
Modulation by Mtb of host immune system	R-HSA-9637628	1.496813e-01	0.825
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.448786e-01	0.839
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	2.625311e-01	0.581
Ionotropic activity of kainate receptors	R-HSA-451306	2.625311e-01	0.581
Innate Immune System	R-HSA-168249	2.650366e-01	0.577
IGF1R signaling cascade	R-HSA-2428924	2.666578e-01	0.574
Toll-like Receptor Cascades	R-HSA-168898	2.748809e-01	0.561
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	2.782175e-01	0.556
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	2.782175e-01	0.556
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.782175e-01	0.556
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	2.789376e-01	0.554
RNA Polymerase III Transcription	R-HSA-74158	2.789376e-01	0.554
Transport to the Golgi and subsequent modification	R-HSA-948021	2.816789e-01	0.550
Activation of TRKA receptors	R-HSA-187015	2.834489e-01	0.548
Activated NTRK2 signals through CDK5	R-HSA-9032845	2.834489e-01	0.548
MET activates PI3K/AKT signaling	R-HSA-8851907	2.834489e-01	0.548
TRIF-mediated programmed cell death	R-HSA-2562578	2.834489e-01	0.548
Recycling of eIF2:GDP	R-HSA-72731	2.834489e-01	0.548
Disinhibition of SNARE formation	R-HSA-114516	2.834489e-01	0.548
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	2.834489e-01	0.548
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.834489e-01	0.548
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.840545e-01	0.547
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.877830e-01	0.541
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.877830e-01	0.541
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	2.877830e-01	0.541
Germ layer formation at gastrulation	R-HSA-9754189	2.877830e-01	0.541
The NLRP3 inflammasome	R-HSA-844456	2.877830e-01	0.541
Maturation of nucleoprotein	R-HSA-9694631	2.877830e-01	0.541
Syndecan interactions	R-HSA-3000170	2.939089e-01	0.532
Growth hormone receptor signaling	R-HSA-982772	2.939089e-01	0.532
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.979054e-01	0.526
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	2.979054e-01	0.526
Activation of kainate receptors upon glutamate binding	R-HSA-451326	2.979054e-01	0.526
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	2.988300e-01	0.525
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	3.030866e-01	0.518
NRAGE signals death through JNK	R-HSA-193648	3.030866e-01	0.518
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.032989e-01	0.518
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	3.034005e-01	0.518
Activated NTRK2 signals through PLCG1	R-HSA-9026527	3.051759e-01	0.515
HCN channels	R-HSA-1296061	3.051759e-01	0.515
Inhibition of TSC complex formation by PKB	R-HSA-165181	3.051759e-01	0.515
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	3.051759e-01	0.515
TNFR1-mediated ceramide production	R-HSA-5626978	3.051759e-01	0.515
MTF1 activates gene expression	R-HSA-5660489	3.051759e-01	0.515
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	3.096199e-01	0.509
Drug-mediated inhibition of MET activation	R-HSA-9734091	3.096199e-01	0.509
MGMT-mediated DNA damage reversal	R-HSA-5657655	3.096199e-01	0.509
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	3.096199e-01	0.509
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9632697	3.096199e-01	0.509
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	R-HSA-5619110	3.096199e-01	0.509
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	3.096199e-01	0.509
SARS-CoV-1 targets PDZ proteins in cell-cell junction	R-HSA-9692912	3.096199e-01	0.509
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	3.096199e-01	0.509
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	3.096199e-01	0.509
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	3.096199e-01	0.509
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9630791	3.096199e-01	0.509
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	3.096199e-01	0.509
TGFBR2 MSI Frameshift Mutants in Cancer	R-HSA-3642279	3.096199e-01	0.509
Formation of editosomes by ADAR proteins	R-HSA-77042	3.096199e-01	0.509
Inhibition of PKR	R-HSA-169131	3.096199e-01	0.509
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.136913e-01	0.503
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	3.136913e-01	0.503
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.195677e-01	0.495
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.195677e-01	0.495
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.195677e-01	0.495
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.195677e-01	0.495
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.195677e-01	0.495
Protein hydroxylation	R-HSA-9629569	3.195677e-01	0.495
IRS-mediated signalling	R-HSA-112399	3.225862e-01	0.491
Formation of RNA Pol II elongation complex	R-HSA-112382	3.237349e-01	0.490
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.247596e-01	0.488
Activated NTRK2 signals through FYN	R-HSA-9032500	3.335287e-01	0.477
Interleukin-18 signaling	R-HSA-9012546	3.335287e-01	0.477
Activated NTRK2 signals through PI3K	R-HSA-9028335	3.335287e-01	0.477
Interleukin-9 signaling	R-HSA-8985947	3.335287e-01	0.477
Interleukin-23 signaling	R-HSA-9020933	3.335287e-01	0.477
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	3.335287e-01	0.477
SLC-mediated bile acid transport	R-HSA-9958517	3.335287e-01	0.477
Ca2+ pathway	R-HSA-4086398	3.361005e-01	0.474
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.427013e-01	0.465
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.427013e-01	0.465
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.443797e-01	0.463
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	3.446812e-01	0.463
Leading Strand Synthesis	R-HSA-69109	3.446812e-01	0.463
Polymerase switching	R-HSA-69091	3.446812e-01	0.463
Interleukin-15 signaling	R-HSA-8983432	3.446812e-01	0.463
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	3.446812e-01	0.463
Disorders of Nervous System Development	R-HSA-9697154	3.446812e-01	0.463
Pervasive developmental disorders	R-HSA-9005895	3.446812e-01	0.463
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	3.446812e-01	0.463
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	3.464802e-01	0.460
SHC1 events in ERBB4 signaling	R-HSA-1250347	3.496979e-01	0.456
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	3.496979e-01	0.456
Synthesis of PG	R-HSA-1483148	3.496979e-01	0.456
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	3.497011e-01	0.456
RAS processing	R-HSA-9648002	3.497011e-01	0.456
Plasma lipoprotein clearance	R-HSA-8964043	3.497011e-01	0.456
Signaling by NOTCH2	R-HSA-1980145	3.510524e-01	0.455
Sensory processing of sound	R-HSA-9659379	3.513302e-01	0.454
ERK/MAPK targets	R-HSA-198753	3.518291e-01	0.454
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.520162e-01	0.453
Interleukin-7 signaling	R-HSA-1266695	3.523899e-01	0.453
Insulin receptor signalling cascade	R-HSA-74751	3.595789e-01	0.444
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.681484e-01	0.434
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	3.720354e-01	0.429
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	3.720354e-01	0.429
SMAC (DIABLO) binds to IAPs	R-HSA-111463	3.720354e-01	0.429
Post-transcriptional silencing by small RNAs	R-HSA-426496	3.720354e-01	0.429
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	3.720354e-01	0.429
NTRK2 activates RAC1	R-HSA-9032759	3.720354e-01	0.429
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	3.720354e-01	0.429
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	3.720354e-01	0.429
Pyrophosphate hydrolysis	R-HSA-71737	3.720354e-01	0.429
Reelin signalling pathway	R-HSA-8866376	3.720354e-01	0.429
HIV Transcription Elongation	R-HSA-167169	3.739296e-01	0.427
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	3.739296e-01	0.427
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	3.739296e-01	0.427
Formation of Incision Complex in GG-NER	R-HSA-5696395	3.739296e-01	0.427
Interleukin-17 signaling	R-HSA-448424	3.755367e-01	0.425
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.767752e-01	0.424
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	3.828340e-01	0.417
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	3.834530e-01	0.416
Lipophagy	R-HSA-9613354	3.834530e-01	0.416
Interleukin-21 signaling	R-HSA-9020958	3.834530e-01	0.416
Calcineurin activates NFAT	R-HSA-2025928	3.834530e-01	0.416
Activation of the AP-1 family of transcription factors	R-HSA-450341	3.834530e-01	0.416
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.834530e-01	0.416
Cellular response to mitochondrial stress	R-HSA-9840373	3.834530e-01	0.416
Unwinding of DNA	R-HSA-176974	3.834530e-01	0.416
Regulation of CDH11 gene transcription	R-HSA-9762293	3.834530e-01	0.416
Interleukin-1 processing	R-HSA-448706	3.834530e-01	0.416
Opioid Signalling	R-HSA-111885	3.845904e-01	0.415
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	3.851852e-01	0.414
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	3.851852e-01	0.414
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.858983e-01	0.414
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.858983e-01	0.414
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	3.858983e-01	0.414
Regulation of FZD by ubiquitination	R-HSA-4641263	3.858983e-01	0.414
Uptake and function of anthrax toxins	R-HSA-5210891	3.858983e-01	0.414
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	3.861646e-01	0.413
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	3.861646e-01	0.413
Maturation of nucleoprotein	R-HSA-9683610	3.861646e-01	0.413
FOXO-mediated transcription	R-HSA-9614085	3.882727e-01	0.411
PI3K Cascade	R-HSA-109704	3.901729e-01	0.409
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	3.920774e-01	0.407
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	3.984300e-01	0.400
RUNX2 regulates bone development	R-HSA-8941326	4.026353e-01	0.395
DNA strand elongation	R-HSA-69190	4.071500e-01	0.390
RNA Polymerase I Transcription Termination	R-HSA-73863	4.118734e-01	0.385
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	4.118734e-01	0.385
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	4.118734e-01	0.385
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	4.158199e-01	0.381
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	4.168181e-01	0.380
Signaling by TGFBR3	R-HSA-9839373	4.173648e-01	0.379
FOXO-mediated transcription of cell death genes	R-HSA-9614657	4.219792e-01	0.375
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.219792e-01	0.375
PKA activation	R-HSA-163615	4.219792e-01	0.375
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	4.219792e-01	0.375
Mismatch Repair	R-HSA-5358508	4.219792e-01	0.375
Platelet sensitization by LDL	R-HSA-432142	4.219792e-01	0.375
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	4.219792e-01	0.375
FGFR4 mutant receptor activation	R-HSA-1839128	4.263792e-01	0.370
NTRK3 as a dependence receptor	R-HSA-9603505	4.263792e-01	0.370
Interactions of Tat with host cellular proteins	R-HSA-176034	4.263792e-01	0.370
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	4.263792e-01	0.370
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	4.263792e-01	0.370
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	4.263792e-01	0.370
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	4.263792e-01	0.370
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	R-HSA-5678420	4.263792e-01	0.370
Defective HK1 causes hexokinase deficiency (HK deficiency)	R-HSA-5619056	4.263792e-01	0.370
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	4.263792e-01	0.370
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	4.263792e-01	0.370
PTEN Loss of Function in Cancer	R-HSA-5674404	4.263792e-01	0.370
Signaling by TCF7L2 mutants	R-HSA-5339700	4.263792e-01	0.370
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	4.263792e-01	0.370
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5660724	4.263792e-01	0.370
Beta-ketothiolase deficiency	R-HSA-9915355	4.263792e-01	0.370
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	4.263792e-01	0.370
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	4.263792e-01	0.370
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	4.263792e-01	0.370
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	4.263792e-01	0.370
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	R-HSA-5619081	4.263792e-01	0.370
Defective GFPT1 causes CMSTA1	R-HSA-4085023	4.263792e-01	0.370
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	4.263792e-01	0.370
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	4.263792e-01	0.370
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	4.263792e-01	0.370
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	4.263792e-01	0.370
Signaling by kinase domain mutants of KIT	R-HSA-9669933	4.263792e-01	0.370
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	4.263792e-01	0.370
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	4.263792e-01	0.370
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	4.263792e-01	0.370
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	4.263792e-01	0.370
Defective SLC12A3 causes Gitelman syndrome (GS)	R-HSA-5619087	4.263792e-01	0.370
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	4.263792e-01	0.370
Transport of connexins along the secretory pathway	R-HSA-190827	4.263792e-01	0.370
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	4.263792e-01	0.370
Oligomerization of connexins into connexons	R-HSA-190704	4.263792e-01	0.370
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	4.272922e-01	0.369
Binding and entry of HIV virion	R-HSA-173107	4.324712e-01	0.364
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.324712e-01	0.364
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	4.324712e-01	0.364
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.324712e-01	0.364
Signal attenuation	R-HSA-74749	4.324712e-01	0.364
Uptake and actions of bacterial toxins	R-HSA-5339562	4.344485e-01	0.362
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	4.361589e-01	0.360
CLEC7A/inflammasome pathway	R-HSA-5660668	4.361589e-01	0.360
NGF-independant TRKA activation	R-HSA-187024	4.361589e-01	0.360
Signalling to p38 via RIT and RIN	R-HSA-187706	4.361589e-01	0.360
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	4.361589e-01	0.360
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	4.361589e-01	0.360
IkBA variant leads to EDA-ID	R-HSA-5603029	4.361589e-01	0.360
Noncanonical activation of NOTCH3	R-HSA-9017802	4.361589e-01	0.360
CDC6 association with the ORC:origin complex	R-HSA-68689	4.361589e-01	0.360
VEGF binds to VEGFR leading to receptor dimerization	R-HSA-195399	4.361589e-01	0.360
VEGF ligand-receptor interactions	R-HSA-194313	4.361589e-01	0.360
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	4.361589e-01	0.360
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	4.361589e-01	0.360
Sodium-coupled phosphate cotransporters	R-HSA-427652	4.361589e-01	0.360
Interferon gamma signaling	R-HSA-877300	4.391417e-01	0.357
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.415507e-01	0.355
HIV elongation arrest and recovery	R-HSA-167287	4.415507e-01	0.355
Formation of the Early Elongation Complex	R-HSA-113418	4.415507e-01	0.355
Pausing and recovery of HIV elongation	R-HSA-167290	4.415507e-01	0.355
Pyroptosis	R-HSA-5620971	4.415507e-01	0.355
Phase 0 - rapid depolarisation	R-HSA-5576892	4.415507e-01	0.355
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.437415e-01	0.353
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.471547e-01	0.350
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	4.491002e-01	0.348
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.514241e-01	0.345
FCGR3A-mediated phagocytosis	R-HSA-9664422	4.570239e-01	0.340
Parasite infection	R-HSA-9664407	4.570239e-01	0.340
Leishmania phagocytosis	R-HSA-9664417	4.570239e-01	0.340
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	4.621860e-01	0.335
Gluconeogenesis	R-HSA-70263	4.636905e-01	0.334
Ion transport by P-type ATPases	R-HSA-936837	4.641046e-01	0.333
G beta:gamma signalling through BTK	R-HSA-8964315	4.676685e-01	0.330
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	4.676685e-01	0.330
mRNA Capping	R-HSA-72086	4.709710e-01	0.327
Regulation of beta-cell development	R-HSA-186712	4.710761e-01	0.327
Activated NTRK3 signals through RAS	R-HSA-9034864	4.799846e-01	0.319
Bicarbonate transporters	R-HSA-425381	4.799846e-01	0.319
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	4.799846e-01	0.319
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	4.809732e-01	0.318
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	4.809732e-01	0.318
Signaling by NOTCH1	R-HSA-1980143	4.892862e-01	0.310
Negative regulation of FGFR2 signaling	R-HSA-5654727	4.893477e-01	0.310
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.920879e-01	0.308
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.920879e-01	0.308
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.920879e-01	0.308
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.920879e-01	0.308
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.920879e-01	0.308
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	4.926823e-01	0.307
PTK6 promotes HIF1A stabilization	R-HSA-8857538	4.965598e-01	0.304
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	4.965598e-01	0.304
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	4.965598e-01	0.304
Signaling by LTK in cancer	R-HSA-9842640	4.965598e-01	0.304
Chylomicron clearance	R-HSA-8964026	4.965598e-01	0.304
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	4.965598e-01	0.304
G2/M DNA replication checkpoint	R-HSA-69478	4.965598e-01	0.304
Autointegration results in viral DNA circles	R-HSA-177539	4.965598e-01	0.304
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	4.965598e-01	0.304
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	4.965598e-01	0.304
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	4.965598e-01	0.304
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	4.965598e-01	0.304
Regulation of NFE2L2 gene expression	R-HSA-9818749	4.965598e-01	0.304
Integration of viral DNA into host genomic DNA	R-HSA-175567	4.965598e-01	0.304
Neurofascin interactions	R-HSA-447043	4.965598e-01	0.304
Downstream signaling of activated FGFR4	R-HSA-5654716	4.999893e-01	0.301
RNA Polymerase III Transcription Initiation	R-HSA-76046	4.999893e-01	0.301
Activation of the pre-replicative complex	R-HSA-68962	4.999893e-01	0.301
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	5.052386e-01	0.297
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	5.052386e-01	0.297
Phosphorylation of the APC/C	R-HSA-176412	5.069603e-01	0.295
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.069603e-01	0.295
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	5.069603e-01	0.295
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	5.069603e-01	0.295
Regulation of BACH1 activity	R-HSA-9708530	5.069603e-01	0.295
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.122616e-01	0.291
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	5.122616e-01	0.291
Downstream signaling of activated FGFR1	R-HSA-5654687	5.161192e-01	0.287
PERK regulates gene expression	R-HSA-381042	5.161192e-01	0.287
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	5.192729e-01	0.285
Signaling by Insulin receptor	R-HSA-74752	5.211817e-01	0.283
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	5.233973e-01	0.281
NTF3 activates NTRK2 (TRKB) signaling	R-HSA-9025046	5.233973e-01	0.281
NTF4 activates NTRK2 (TRKB) signaling	R-HSA-9026357	5.233973e-01	0.281
BDNF activates NTRK2 (TRKB) signaling	R-HSA-9024909	5.233973e-01	0.281
NTF3 activates NTRK3 signaling	R-HSA-9034013	5.233973e-01	0.281
Defective ALG9 causes CDG-1l	R-HSA-4720454	5.233973e-01	0.281
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	5.233973e-01	0.281
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	R-HSA-5619104	5.233973e-01	0.281
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	5.233973e-01	0.281
Glycogen storage disease type IV (GBE1)	R-HSA-3878781	5.233973e-01	0.281
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	5.233973e-01	0.281
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	5.233973e-01	0.281
mRNA Editing: A to I Conversion	R-HSA-75064	5.233973e-01	0.281
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	5.233973e-01	0.281
Defective ABCC8 can cause hypo- and hyper-glycemias	R-HSA-5683177	5.233973e-01	0.281
C6 deamination of adenosine	R-HSA-75102	5.233973e-01	0.281
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	R-HSA-180897	5.233973e-01	0.281
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.255345e-01	0.279
Activated NTRK2 signals through RAS	R-HSA-9026519	5.255345e-01	0.279
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.255345e-01	0.279
PI3K events in ERBB4 signaling	R-HSA-1250342	5.255345e-01	0.279
Signaling by GSK3beta mutants	R-HSA-5339716	5.255345e-01	0.279
Endosomal/Vacuolar pathway	R-HSA-1236977	5.255345e-01	0.279
Reduction of cytosolic Ca++ levels	R-HSA-418359	5.255345e-01	0.279
ABC transporter disorders	R-HSA-5619084	5.266499e-01	0.278
Lagging Strand Synthesis	R-HSA-69186	5.268366e-01	0.278
PKA-mediated phosphorylation of CREB	R-HSA-111931	5.268366e-01	0.278
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	5.268366e-01	0.278
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.301802e-01	0.276
Lysosome Vesicle Biogenesis	R-HSA-432720	5.423990e-01	0.266
Developmental Cell Lineages	R-HSA-9734767	5.424645e-01	0.266
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	5.426850e-01	0.265
Transcription of the HIV genome	R-HSA-167172	5.441302e-01	0.264
Mitochondrial biogenesis	R-HSA-1592230	5.491101e-01	0.260
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	5.526632e-01	0.258
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	5.526632e-01	0.258
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	5.526632e-01	0.258
DAG1 core M1 glycosylations	R-HSA-8932506	5.526632e-01	0.258
NOSTRIN mediated eNOS trafficking	R-HSA-203641	5.526632e-01	0.258
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	5.526632e-01	0.258
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	5.526632e-01	0.258
Netrin mediated repulsion signals	R-HSA-418886	5.526632e-01	0.258
Activation of PUMA and translocation to mitochondria	R-HSA-139915	5.526632e-01	0.258
CHL1 interactions	R-HSA-447041	5.526632e-01	0.258
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	5.526632e-01	0.258
Parasitic Infection Pathways	R-HSA-9824443	5.592149e-01	0.252
Leishmania infection	R-HSA-9658195	5.592149e-01	0.252
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	5.599374e-01	0.252
Ribavirin ADME	R-HSA-9755088	5.599374e-01	0.252
Early SARS-CoV-2 Infection Events	R-HSA-9772572	5.642926e-01	0.248
MET activates RAS signaling	R-HSA-8851805	5.687867e-01	0.245
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	5.687867e-01	0.245
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.687867e-01	0.245
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	5.687867e-01	0.245
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	5.687867e-01	0.245
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	5.687867e-01	0.245
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	5.687867e-01	0.245
SHC-related events triggered by IGF1R	R-HSA-2428933	5.687867e-01	0.245
Role of second messengers in netrin-1 signaling	R-HSA-418890	5.687867e-01	0.245
Trafficking and processing of endosomal TLR	R-HSA-1679131	5.687867e-01	0.245
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.687867e-01	0.245
GRB2 events in EGFR signaling	R-HSA-179812	5.687867e-01	0.245
Signaling by LTK	R-HSA-9842663	5.687867e-01	0.245
ABC-family proteins mediated transport	R-HSA-382556	5.793332e-01	0.237
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.812589e-01	0.236
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	5.812589e-01	0.236
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.833978e-01	0.234
Cardiogenesis	R-HSA-9733709	5.833978e-01	0.234
PI-3K cascade:FGFR1	R-HSA-5654689	5.918344e-01	0.228
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	5.918344e-01	0.228
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	5.918344e-01	0.228
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	5.918344e-01	0.228
MET promotes cell motility	R-HSA-8875878	5.931295e-01	0.227
Inflammasomes	R-HSA-622312	6.011830e-01	0.221
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	6.011830e-01	0.221
Axonal growth stimulation	R-HSA-209563	6.040110e-01	0.219
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	6.040110e-01	0.219
IRAK4 deficiency (TLR5)	R-HSA-5603037	6.040110e-01	0.219
Signalling to STAT3	R-HSA-198745	6.040110e-01	0.219
MET activates STAT3	R-HSA-8875791	6.040110e-01	0.219
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	6.040110e-01	0.219
Activation of BMF and translocation to mitochondria	R-HSA-139910	6.040110e-01	0.219
Activation of BIM and translocation to mitochondria	R-HSA-111446	6.040110e-01	0.219
Intracellular oxygen transport	R-HSA-8981607	6.040110e-01	0.219
Histamine receptors	R-HSA-390650	6.040110e-01	0.219
RSK activation	R-HSA-444257	6.041951e-01	0.219
Regulation by c-FLIP	R-HSA-3371378	6.041951e-01	0.219
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.041951e-01	0.219
Dimerization of procaspase-8	R-HSA-69416	6.041951e-01	0.219
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.041951e-01	0.219
DAG1 core M2 glycosylations	R-HSA-8932504	6.041951e-01	0.219
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.041951e-01	0.219
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	6.041951e-01	0.219
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.041951e-01	0.219
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	6.041951e-01	0.219
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	6.041951e-01	0.219
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.041951e-01	0.219
Activation of RAS in B cells	R-HSA-1169092	6.041951e-01	0.219
Co-stimulation by ICOS	R-HSA-9927354	6.041951e-01	0.219
Sodium/Proton exchangers	R-HSA-425986	6.041951e-01	0.219
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	6.095150e-01	0.215
Microbial factors inhibit CASP4 activity	R-HSA-9956593	6.095150e-01	0.215
Platelet Adhesion to exposed collagen	R-HSA-75892	6.095150e-01	0.215
Reversible hydration of carbon dioxide	R-HSA-1475029	6.095150e-01	0.215
Replication of the SARS-CoV-1 genome	R-HSA-9682706	6.095150e-01	0.215
Resolution of D-Loop Structures	R-HSA-5693537	6.096471e-01	0.215
Effects of PIP2 hydrolysis	R-HSA-114508	6.096471e-01	0.215
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.096471e-01	0.215
Glucagon signaling in metabolic regulation	R-HSA-163359	6.096471e-01	0.215
G beta:gamma signalling through PLC beta	R-HSA-418217	6.158901e-01	0.210
RNA Polymerase III Transcription Termination	R-HSA-73980	6.158901e-01	0.210
Apoptotic factor-mediated response	R-HSA-111471	6.158901e-01	0.210
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.158901e-01	0.210
Presynaptic function of Kainate receptors	R-HSA-500657	6.158901e-01	0.210
PKA activation in glucagon signalling	R-HSA-164378	6.158901e-01	0.210
Tie2 Signaling	R-HSA-210993	6.158901e-01	0.210
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.174310e-01	0.209
G alpha (z) signalling events	R-HSA-418597	6.176605e-01	0.209
Cardiac conduction	R-HSA-5576891	6.197551e-01	0.208
Regulation of PTEN mRNA translation	R-HSA-8943723	6.224086e-01	0.206
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	6.224086e-01	0.206
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	6.224086e-01	0.206
Nuclear Receptor transcription pathway	R-HSA-383280	6.265188e-01	0.203
DARPP-32 events	R-HSA-180024	6.288026e-01	0.201
Downstream signaling of activated FGFR3	R-HSA-5654708	6.288026e-01	0.201
Stimuli-sensing channels	R-HSA-2672351	6.321070e-01	0.199
Signal amplification	R-HSA-392518	6.349875e-01	0.197
Diseases associated with the TLR signaling cascade	R-HSA-5602358	6.409416e-01	0.193
Diseases of Immune System	R-HSA-5260271	6.409416e-01	0.193
NCAM signaling for neurite out-growth	R-HSA-375165	6.439301e-01	0.191
Fanconi Anemia Pathway	R-HSA-6783310	6.466669e-01	0.189
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	6.475850e-01	0.189
Removal of the Flap Intermediate	R-HSA-69166	6.475850e-01	0.189
Retrograde neurotrophin signalling	R-HSA-177504	6.475850e-01	0.189
Malate-aspartate shuttle	R-HSA-9856872	6.475850e-01	0.189
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	6.475850e-01	0.189
HDL assembly	R-HSA-8963896	6.475850e-01	0.189
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.486760e-01	0.188
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	6.510967e-01	0.186
CASP8 activity is inhibited	R-HSA-5218900	6.510967e-01	0.186
p75NTR regulates axonogenesis	R-HSA-193697	6.510967e-01	0.186
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	6.510967e-01	0.186
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.510967e-01	0.186
Regulated proteolysis of p75NTR	R-HSA-193692	6.510967e-01	0.186
Defects in biotin (Btn) metabolism	R-HSA-3323169	6.510967e-01	0.186
Respiratory syncytial virus genome replication	R-HSA-9834752	6.510967e-01	0.186
Plasma lipoprotein assembly	R-HSA-8963898	6.515707e-01	0.186
The phototransduction cascade	R-HSA-2514856	6.521738e-01	0.186
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	6.552760e-01	0.184
RSV-host interactions	R-HSA-9833110	6.557885e-01	0.183
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.625880e-01	0.179
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	6.675229e-01	0.176
Regulation of pyruvate metabolism	R-HSA-9861718	6.679225e-01	0.175
betaKlotho-mediated ligand binding	R-HSA-1307965	6.709933e-01	0.173
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	6.709933e-01	0.173
Nucleotide catabolism defects	R-HSA-9735786	6.709933e-01	0.173
ATP sensitive Potassium channels	R-HSA-1296025	6.709933e-01	0.173
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	6.709933e-01	0.173
GRB7 events in ERBB2 signaling	R-HSA-1306955	6.709933e-01	0.173
Signaling by MAP2K mutants	R-HSA-9652169	6.709933e-01	0.173
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	6.709933e-01	0.173
Transcriptional activation of p53 responsive genes	R-HSA-69560	6.709933e-01	0.173
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	6.709933e-01	0.173
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	6.709933e-01	0.173
Dopamine receptors	R-HSA-390651	6.709933e-01	0.173
Activation of NOXA and translocation to mitochondria	R-HSA-111448	6.709933e-01	0.173
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	6.709933e-01	0.173
NADE modulates death signalling	R-HSA-205025	6.709933e-01	0.173
Electric Transmission Across Gap Junctions	R-HSA-112303	6.709933e-01	0.173
Transmission across Electrical Synapses	R-HSA-112307	6.709933e-01	0.173
Toxicity of tetanus toxin (tetX)	R-HSA-5250982	6.709933e-01	0.173
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.728137e-01	0.172
FRS-mediated FGFR1 signaling	R-HSA-5654693	6.792578e-01	0.168
HDMs demethylate histones	R-HSA-3214842	6.792578e-01	0.168
Glycogen breakdown (glycogenolysis)	R-HSA-70221	6.792578e-01	0.168
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	6.792578e-01	0.168
Regulation of PD-L1(CD274) translation	R-HSA-9909620	6.795460e-01	0.168
PI-3K cascade:FGFR4	R-HSA-5654720	6.795460e-01	0.168
VxPx cargo-targeting to cilium	R-HSA-5620916	6.795460e-01	0.168
Ion channel transport	R-HSA-983712	6.812740e-01	0.167
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.813860e-01	0.167
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	6.829373e-01	0.166
Beta-catenin phosphorylation cascade	R-HSA-196299	6.829373e-01	0.166
SHC1 events in EGFR signaling	R-HSA-180336	6.829373e-01	0.166
Processive synthesis on the lagging strand	R-HSA-69183	6.829373e-01	0.166
Biotin transport and metabolism	R-HSA-196780	6.829373e-01	0.166
DNA Damage Reversal	R-HSA-73942	6.829373e-01	0.166
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.854083e-01	0.164
Translation of Structural Proteins	R-HSA-9683701	6.854083e-01	0.164
Synthesis of PC	R-HSA-1483191	6.884031e-01	0.162
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	6.934599e-01	0.159
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	6.934599e-01	0.159
PI Metabolism	R-HSA-1483255	6.940453e-01	0.159
Extension of Telomeres	R-HSA-180786	6.948672e-01	0.158
Disease	R-HSA-1643685	7.029134e-01	0.153
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	7.045882e-01	0.152
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.054313e-01	0.152
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.054313e-01	0.152
TRP channels	R-HSA-3295583	7.054313e-01	0.152
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.054313e-01	0.152
GPER1 signaling	R-HSA-9634597	7.080837e-01	0.150
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	7.082773e-01	0.150
G-protein activation	R-HSA-202040	7.084668e-01	0.150
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	7.084668e-01	0.150
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	7.084668e-01	0.150
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	7.155740e-01	0.145
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	7.155740e-01	0.145
Class I peroxisomal membrane protein import	R-HSA-9603798	7.155740e-01	0.145
Killing mechanisms	R-HSA-9664420	7.155740e-01	0.145
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	7.155740e-01	0.145
Atorvastatin ADME	R-HSA-9754706	7.155740e-01	0.145
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	7.155740e-01	0.145
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	7.155740e-01	0.145
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.177754e-01	0.144
Post-translational protein phosphorylation	R-HSA-8957275	7.181209e-01	0.144
Response of Mtb to phagocytosis	R-HSA-9637690	7.262618e-01	0.139
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	7.262892e-01	0.139
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	7.266485e-01	0.139
G2 Phase	R-HSA-68911	7.266485e-01	0.139
NOSIP mediated eNOS trafficking	R-HSA-203754	7.266485e-01	0.139
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	7.266485e-01	0.139
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	7.266485e-01	0.139
Defective F9 activation	R-HSA-9673221	7.266485e-01	0.139
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	7.266485e-01	0.139
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	7.266485e-01	0.139
Activation of AKT2	R-HSA-165158	7.266485e-01	0.139
PTK6 Down-Regulation	R-HSA-8849472	7.266485e-01	0.139
Muscarinic acetylcholine receptors	R-HSA-390648	7.266485e-01	0.139
Activation of AMPA receptors	R-HSA-399710	7.266485e-01	0.139
Inositol transporters	R-HSA-429593	7.266485e-01	0.139
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	7.266485e-01	0.139
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	7.266485e-01	0.139
Assembly of Viral Components at the Budding Site	R-HSA-168316	7.266485e-01	0.139
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	7.269462e-01	0.138
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	7.300741e-01	0.137
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	7.300741e-01	0.137
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.300741e-01	0.137
Signaling by FGFR3 in disease	R-HSA-5655332	7.300741e-01	0.137
ER Quality Control Compartment (ERQC)	R-HSA-901032	7.300741e-01	0.137
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.314781e-01	0.136
Signaling by APC mutants	R-HSA-4839744	7.314781e-01	0.136
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	7.314781e-01	0.136
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	7.314781e-01	0.136
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	7.314781e-01	0.136
Formation of the posterior neural plate	R-HSA-9832991	7.314781e-01	0.136
Synthesis of PI	R-HSA-1483226	7.314781e-01	0.136
Chylomicron assembly	R-HSA-8963888	7.314781e-01	0.136
vRNP Assembly	R-HSA-192905	7.314781e-01	0.136
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.314781e-01	0.136
Transport of RCbl within the body	R-HSA-9758890	7.314781e-01	0.136
RHOBTB3 ATPase cycle	R-HSA-9706019	7.314781e-01	0.136
Suppression of apoptosis	R-HSA-9635465	7.314781e-01	0.136
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.314781e-01	0.136
Attachment and Entry	R-HSA-9694614	7.354362e-01	0.133
Signaling by FGFR2 in disease	R-HSA-5655253	7.449791e-01	0.128
TRAF3-dependent IRF activation pathway	R-HSA-918233	7.455449e-01	0.128
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	7.455449e-01	0.128
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	7.455449e-01	0.128
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	7.464639e-01	0.127
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.488869e-01	0.126
Insulin receptor recycling	R-HSA-77387	7.531878e-01	0.123
Platelet homeostasis	R-HSA-418346	7.593518e-01	0.120
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.604783e-01	0.119
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.604783e-01	0.119
LDL clearance	R-HSA-8964038	7.604783e-01	0.119
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.604783e-01	0.119
Integration of energy metabolism	R-HSA-163685	7.613548e-01	0.118
Iron uptake and transport	R-HSA-917937	7.629818e-01	0.117
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.633756e-01	0.117
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.654088e-01	0.116
Signaling by activated point mutants of FGFR1	R-HSA-1839122	7.654088e-01	0.116
Proton-coupled monocarboxylate transport	R-HSA-433692	7.654088e-01	0.116
Signaling by AXIN mutants	R-HSA-4839735	7.654088e-01	0.116
Signaling by AMER1 mutants	R-HSA-4839748	7.654088e-01	0.116
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.654088e-01	0.116
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.691450e-01	0.114
Calnexin/calreticulin cycle	R-HSA-901042	7.691450e-01	0.114
NPAS4 regulates expression of target genes	R-HSA-9768919	7.691450e-01	0.114
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	7.691450e-01	0.114
Plus-strand DNA synthesis	R-HSA-164525	7.728917e-01	0.112
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	7.728917e-01	0.112
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	7.728917e-01	0.112
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)	R-HSA-5619063	7.728917e-01	0.112
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	7.728917e-01	0.112
Signaling by MAPK mutants	R-HSA-9652817	7.728917e-01	0.112
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	7.728917e-01	0.112
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	7.728917e-01	0.112
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	7.728917e-01	0.112
Signaling by MST1	R-HSA-8852405	7.728917e-01	0.112
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	7.728917e-01	0.112
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	7.728917e-01	0.112
Aryl hydrocarbon receptor signalling	R-HSA-8937144	7.728917e-01	0.112
Pentose phosphate pathway disease	R-HSA-6791465	7.728917e-01	0.112
PKB-mediated events	R-HSA-109703	7.728917e-01	0.112
Cam-PDE 1 activation	R-HSA-111957	7.728917e-01	0.112
PDE3B signalling	R-HSA-165160	7.728917e-01	0.112
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	7.728917e-01	0.112
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	7.728917e-01	0.112
Release of apoptotic factors from the mitochondria	R-HSA-111457	7.728917e-01	0.112
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	7.728917e-01	0.112
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	7.728917e-01	0.112
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	7.728917e-01	0.112
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	7.729364e-01	0.112
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	7.729364e-01	0.112
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	7.729364e-01	0.112
Replication of the SARS-CoV-2 genome	R-HSA-9694686	7.729364e-01	0.112
Neddylation	R-HSA-8951664	7.782113e-01	0.109
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	7.835883e-01	0.106
Downstream signaling of activated FGFR2	R-HSA-5654696	7.881593e-01	0.103
Translation of Structural Proteins	R-HSA-9694635	7.902308e-01	0.102
Cytoprotection by HMOX1	R-HSA-9707564	7.903154e-01	0.102
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	7.912179e-01	0.102
Amino acids regulate mTORC1	R-HSA-9639288	7.940740e-01	0.100
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	7.949106e-01	0.100
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.949106e-01	0.100
Maple Syrup Urine Disease	R-HSA-9865114	7.955469e-01	0.099
Defective EXT2 causes exostoses 2	R-HSA-3656237	7.955469e-01	0.099
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	7.955469e-01	0.099
Scavenging by Class F Receptors	R-HSA-3000484	7.955469e-01	0.099
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.955469e-01	0.099
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	7.955469e-01	0.099
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.955469e-01	0.099
OAS antiviral response	R-HSA-8983711	7.955469e-01	0.099
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.955469e-01	0.099
Polo-like kinase mediated events	R-HSA-156711	7.978620e-01	0.098
Disorders of transmembrane transporters	R-HSA-5619115	8.019869e-01	0.096
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.036039e-01	0.095
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	8.036618e-01	0.095
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.049786e-01	0.094
SHC-mediated cascade:FGFR1	R-HSA-5654688	8.049786e-01	0.094
TRAF6 mediated NF-kB activation	R-HSA-933542	8.049786e-01	0.094
Triglyceride catabolism	R-HSA-163560	8.059541e-01	0.094
RAB geranylgeranylation	R-HSA-8873719	8.064313e-01	0.093
Metabolism of polyamines	R-HSA-351202	8.064313e-01	0.093
Metabolism of ingested MeSeO2H into MeSeH	R-HSA-5263617	8.113140e-01	0.091
Uncoating of the HIV Virion	R-HSA-162585	8.113140e-01	0.091
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	8.113140e-01	0.091
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	8.113140e-01	0.091
MET Receptor Activation	R-HSA-6806942	8.113140e-01	0.091
HDL clearance	R-HSA-8964011	8.113140e-01	0.091
VLDL assembly	R-HSA-8866423	8.113140e-01	0.091
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.135926e-01	0.090
Cytosolic tRNA aminoacylation	R-HSA-379716	8.164967e-01	0.088
Aquaporin-mediated transport	R-HSA-445717	8.198667e-01	0.086
PI-3K cascade:FGFR3	R-HSA-5654710	8.204538e-01	0.086
E2F mediated regulation of DNA replication	R-HSA-113510	8.204538e-01	0.086
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.204538e-01	0.086
Specification of the neural plate border	R-HSA-9834899	8.204538e-01	0.086
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	8.204538e-01	0.086
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	8.204538e-01	0.086
Protein localization	R-HSA-9609507	8.215719e-01	0.085
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	8.222042e-01	0.085
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	8.222042e-01	0.085
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.222042e-01	0.085
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.245740e-01	0.084
Mitochondrial protein import	R-HSA-1268020	8.325835e-01	0.080
Creatine metabolism	R-HSA-71288	8.408559e-01	0.075
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.425090e-01	0.074
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.425090e-01	0.074
Suppression of phagosomal maturation	R-HSA-9637687	8.425090e-01	0.074
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	8.432378e-01	0.074
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	8.432378e-01	0.074
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	8.432378e-01	0.074
PTK6 Expression	R-HSA-8849473	8.432378e-01	0.074
Opsins	R-HSA-419771	8.432378e-01	0.074
Reuptake of GABA	R-HSA-888593	8.432378e-01	0.074
VLDL clearance	R-HSA-8964046	8.432378e-01	0.074
Ca2+ activated K+ channels	R-HSA-1296052	8.432378e-01	0.074
LDL remodeling	R-HSA-8964041	8.432378e-01	0.074
Phase 3 - rapid repolarisation	R-HSA-5576890	8.432378e-01	0.074
Nef Mediated CD4 Down-regulation	R-HSA-167590	8.432378e-01	0.074
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.456035e-01	0.073
Prolactin receptor signaling	R-HSA-1170546	8.456957e-01	0.073
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.456957e-01	0.073
Physiological factors	R-HSA-5578768	8.456957e-01	0.073
Zinc transporters	R-HSA-435354	8.456957e-01	0.073
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	8.520518e-01	0.070
Insulin processing	R-HSA-264876	8.588745e-01	0.066
Maturation of hRSV A proteins	R-HSA-9828806	8.588745e-01	0.066
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.592189e-01	0.066
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.645373e-01	0.063
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.656637e-01	0.063
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.663295e-01	0.062
Protein lipoylation	R-HSA-9857492	8.663295e-01	0.062
Lysosphingolipid and LPA receptors	R-HSA-419408	8.663295e-01	0.062
Other semaphorin interactions	R-HSA-416700	8.663295e-01	0.062
Formation of the anterior neural plate	R-HSA-9823739	8.663295e-01	0.062
Reverse Transcription of HIV RNA	R-HSA-162589	8.697619e-01	0.061
Minus-strand DNA synthesis	R-HSA-164516	8.697619e-01	0.061
phospho-PLA2 pathway	R-HSA-111995	8.697619e-01	0.061
FGFR1b ligand binding and activation	R-HSA-190370	8.697619e-01	0.061
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	8.697619e-01	0.061
Fructose biosynthesis	R-HSA-5652227	8.697619e-01	0.061
Adrenoceptors	R-HSA-390696	8.697619e-01	0.061
TGFBR3 PTM regulation	R-HSA-9839383	8.697619e-01	0.061
Alpha-defensins	R-HSA-1462054	8.697619e-01	0.061
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.704852e-01	0.060
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.704852e-01	0.060
Peroxisomal protein import	R-HSA-9033241	8.706477e-01	0.060
Amino acid transport across the plasma membrane	R-HSA-352230	8.706477e-01	0.060
Telomere Extension By Telomerase	R-HSA-171319	8.737654e-01	0.059
SHC-mediated cascade:FGFR4	R-HSA-5654719	8.756957e-01	0.058
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	8.756957e-01	0.058
Mitochondrial calcium ion transport	R-HSA-8949215	8.756957e-01	0.058
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.756957e-01	0.058
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.793338e-01	0.056
SLC transporter disorders	R-HSA-5619102	8.800913e-01	0.055
tRNA Aminoacylation	R-HSA-379724	8.808337e-01	0.055
Activation of SMO	R-HSA-5635838	8.844000e-01	0.053
Differentiation of T cells	R-HSA-9945266	8.844000e-01	0.053
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.844000e-01	0.053
Induction of Cell-Cell Fusion	R-HSA-9733458	8.844000e-01	0.053
SLC-mediated transport of amino acids	R-HSA-9958863	8.860166e-01	0.053
Glucagon-type ligand receptors	R-HSA-420092	8.872780e-01	0.052
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.892705e-01	0.051
HIV Transcription Initiation	R-HSA-167161	8.892705e-01	0.051
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.892705e-01	0.051
Intra-Golgi traffic	R-HSA-6811438	8.892705e-01	0.051
Notch-HLH transcription pathway	R-HSA-350054	8.904377e-01	0.050
Neurotoxicity of clostridium toxins	R-HSA-168799	8.904377e-01	0.050
Ethanol oxidation	R-HSA-71384	8.904377e-01	0.050
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	8.917994e-01	0.050
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	8.917994e-01	0.050
mRNA Editing	R-HSA-75072	8.917994e-01	0.050
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	8.917994e-01	0.050
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	8.917994e-01	0.050
Butyrophilin (BTN) family interactions	R-HSA-8851680	8.917994e-01	0.050
Expression of NOTCH2NL genes	R-HSA-9911233	8.917994e-01	0.050
NGF-stimulated transcription	R-HSA-9031628	8.921296e-01	0.050
Post-translational protein modification	R-HSA-597592	8.934421e-01	0.049
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.982927e-01	0.047
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.995090e-01	0.046
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.995090e-01	0.046
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.001837e-01	0.046
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.001837e-01	0.046
Acetylcholine regulates insulin secretion	R-HSA-399997	9.001837e-01	0.046
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.001837e-01	0.046
Galactose catabolism	R-HSA-70370	9.001837e-01	0.046
Passive transport by Aquaporins	R-HSA-432047	9.001837e-01	0.046
Response to metal ions	R-HSA-5660526	9.001837e-01	0.046
Regulation of insulin secretion	R-HSA-422356	9.031177e-01	0.044
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.044467e-01	0.044
Adipogenesis	R-HSA-9843745	9.068927e-01	0.042
RNA Polymerase II Promoter Escape	R-HSA-73776	9.092543e-01	0.041
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	9.101090e-01	0.041
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	9.101090e-01	0.041
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	9.101090e-01	0.041
Metabolism of serotonin	R-HSA-380612	9.101090e-01	0.041
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	9.101090e-01	0.041
Defective factor IX causes hemophilia B	R-HSA-9668250	9.101090e-01	0.041
Metal sequestration by antimicrobial proteins	R-HSA-6799990	9.101090e-01	0.041
Regulation of the apoptosome activity	R-HSA-9627069	9.101090e-01	0.041
Tandem pore domain potassium channels	R-HSA-1296346	9.101090e-01	0.041
Formation of apoptosome	R-HSA-111458	9.101090e-01	0.041
Molecules associated with elastic fibres	R-HSA-2129379	9.105535e-01	0.041
Aspartate and asparagine metabolism	R-HSA-8963693	9.105535e-01	0.041
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.139369e-01	0.039
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	9.139369e-01	0.039
Regulation of NPAS4 gene expression	R-HSA-9768759	9.139369e-01	0.039
Specification of primordial germ cells	R-HSA-9827857	9.139369e-01	0.039
Thromboxane signalling through TP receptor	R-HSA-428930	9.153020e-01	0.038
Complex III assembly	R-HSA-9865881	9.153020e-01	0.038
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.153020e-01	0.038
Inwardly rectifying K+ channels	R-HSA-1296065	9.205039e-01	0.036
Signaling by WNT in cancer	R-HSA-4791275	9.205039e-01	0.036
DAG1 core M3 glycosylations	R-HSA-8932505	9.253211e-01	0.034
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	9.253211e-01	0.034
Utilization of Ketone Bodies	R-HSA-77108	9.253211e-01	0.034
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	9.253211e-01	0.034
LGI-ADAM interactions	R-HSA-5682910	9.253211e-01	0.034
Dissolution of Fibrin Clot	R-HSA-75205	9.253211e-01	0.034
PI-3K cascade:FGFR2	R-HSA-5654695	9.257008e-01	0.034
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.257008e-01	0.034
Activation of G protein gated Potassium channels	R-HSA-1296041	9.257008e-01	0.034
G protein gated Potassium channels	R-HSA-1296059	9.257008e-01	0.034
Acyl chain remodelling of PS	R-HSA-1482801	9.257008e-01	0.034
Formation of the nephric duct	R-HSA-9830364	9.257008e-01	0.034
Hyaluronan degradation	R-HSA-2160916	9.257008e-01	0.034
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.257008e-01	0.034
FGFR1 ligand binding and activation	R-HSA-190242	9.258949e-01	0.033
Nephron development	R-HSA-9831926	9.258949e-01	0.033
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.260351e-01	0.033
Pentose phosphate pathway	R-HSA-71336	9.268547e-01	0.033
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.295248e-01	0.032
Nucleotide biosynthesis	R-HSA-8956320	9.332595e-01	0.030
MET activates PTK2 signaling	R-HSA-8874081	9.349157e-01	0.029
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.349157e-01	0.029
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.349157e-01	0.029
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.362712e-01	0.029
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.362712e-01	0.029
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.374752e-01	0.028
Synthesis of diphthamide-EEF2	R-HSA-5358493	9.379596e-01	0.028
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	9.379596e-01	0.028
Sensing of DNA Double Strand Breaks	R-HSA-5693548	9.379596e-01	0.028
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	9.379596e-01	0.028
Plasmalogen biosynthesis	R-HSA-75896	9.379596e-01	0.028
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	9.379596e-01	0.028
Sodium/Calcium exchangers	R-HSA-425561	9.379596e-01	0.028
Pyruvate metabolism	R-HSA-70268	9.401150e-01	0.027
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.418878e-01	0.026
Cristae formation	R-HSA-8949613	9.430650e-01	0.025
Signaling by BMP	R-HSA-201451	9.430650e-01	0.025
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.446618e-01	0.025
eNOS activation	R-HSA-203615	9.446618e-01	0.025
Hyaluronan metabolism	R-HSA-2142845	9.446618e-01	0.025
Signaling by NODAL	R-HSA-1181150	9.452587e-01	0.024
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.452587e-01	0.024
Mitochondrial protein degradation	R-HSA-9837999	9.465339e-01	0.024
FCERI mediated NF-kB activation	R-HSA-2871837	9.466080e-01	0.024
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.478290e-01	0.023
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.478290e-01	0.023
Synthesis of GDP-mannose	R-HSA-446205	9.484598e-01	0.023
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.502581e-01	0.022
tRNA processing	R-HSA-72306	9.525145e-01	0.021
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.530301e-01	0.021
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.530301e-01	0.021
Phenylalanine metabolism	R-HSA-8964208	9.530301e-01	0.021
SHC-mediated cascade:FGFR3	R-HSA-5654704	9.530301e-01	0.021
Zygotic genome activation (ZGA)	R-HSA-9819196	9.530301e-01	0.021
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.530301e-01	0.021
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.530301e-01	0.021
Azathioprine ADME	R-HSA-9748787	9.565964e-01	0.019
FGFR2 mutant receptor activation	R-HSA-1839126	9.568164e-01	0.019
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	9.571833e-01	0.019
FGFR4 ligand binding and activation	R-HSA-190322	9.571833e-01	0.019
Chylomicron remodeling	R-HSA-8963901	9.571833e-01	0.019
FGFR1c ligand binding and activation	R-HSA-190373	9.571833e-01	0.019
Processing of SMDT1	R-HSA-8949664	9.571833e-01	0.019
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	9.571833e-01	0.019
Diseases of nucleotide metabolism	R-HSA-9735804	9.571833e-01	0.019
Acetylcholine binding and downstream events	R-HSA-181431	9.571833e-01	0.019
Metabolism of proteins	R-HSA-392499	9.584643e-01	0.018
Serine metabolism	R-HSA-977347	9.597395e-01	0.018
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.599149e-01	0.018
Voltage gated Potassium channels	R-HSA-1296072	9.619214e-01	0.017
TRAF6 mediated IRF7 activation	R-HSA-933541	9.619214e-01	0.017
Neurotransmitter clearance	R-HSA-112311	9.621706e-01	0.017
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.632275e-01	0.016
Triglyceride metabolism	R-HSA-8979227	9.639183e-01	0.016
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.644308e-01	0.016
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	9.644308e-01	0.016
Hydrolysis of LPC	R-HSA-1483115	9.644308e-01	0.016
cGMP effects	R-HSA-418457	9.644308e-01	0.016
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	9.644308e-01	0.016
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.644308e-01	0.016
Acyl chain remodeling of CL	R-HSA-1482798	9.644308e-01	0.016
P2Y receptors	R-HSA-417957	9.644308e-01	0.016
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.655238e-01	0.015
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.655238e-01	0.015
Elastic fibre formation	R-HSA-1566948	9.664614e-01	0.015
FCERI mediated MAPK activation	R-HSA-2871796	9.689953e-01	0.014
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.690847e-01	0.014
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.704518e-01	0.013
RNA Polymerase III Chain Elongation	R-HSA-73780	9.704518e-01	0.013
Telomere C-strand synthesis initiation	R-HSA-174430	9.704518e-01	0.013
Signaling by Activin	R-HSA-1502540	9.704518e-01	0.013
Dopamine clearance from the synaptic cleft	R-HSA-379401	9.704518e-01	0.013
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.705039e-01	0.013
Biosynthesis of maresins	R-HSA-9018682	9.705039e-01	0.013
Carnitine shuttle	R-HSA-200425	9.705039e-01	0.013
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.750425e-01	0.011
Recycling of bile acids and salts	R-HSA-159418	9.751177e-01	0.011
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	9.754539e-01	0.011
Phase 4 - resting membrane potential	R-HSA-5576886	9.754539e-01	0.011
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.754539e-01	0.011
Activation of the phototransduction cascade	R-HSA-2485179	9.754539e-01	0.011
Carnitine synthesis	R-HSA-71262	9.754539e-01	0.011
Mitochondrial Uncoupling	R-HSA-166187	9.754539e-01	0.011
Attachment and Entry	R-HSA-9678110	9.754539e-01	0.011
Virus Assembly and Release	R-HSA-168268	9.754539e-01	0.011
COPII-mediated vesicle transport	R-HSA-204005	9.756179e-01	0.011
Cell surface interactions at the vascular wall	R-HSA-202733	9.766166e-01	0.010
Potassium Channels	R-HSA-1296071	9.769798e-01	0.010
Metal ion SLC transporters	R-HSA-425410	9.772417e-01	0.010
Heme degradation	R-HSA-189483	9.784044e-01	0.009
Laminin interactions	R-HSA-3000157	9.784643e-01	0.009
Glycine degradation	R-HSA-6783984	9.796094e-01	0.009
Heme assimilation	R-HSA-9927020	9.796094e-01	0.009
Transcriptional regulation of testis differentiation	R-HSA-9690406	9.796094e-01	0.009
Fibronectin matrix formation	R-HSA-1566977	9.796094e-01	0.009
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.796094e-01	0.009
tRNA modification in the mitochondrion	R-HSA-6787450	9.796094e-01	0.009
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.796094e-01	0.009
Scavenging by Class A Receptors	R-HSA-3000480	9.800305e-01	0.009
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.816199e-01	0.008
Activation of GABAB receptors	R-HSA-991365	9.825019e-01	0.008
GABA B receptor activation	R-HSA-977444	9.825019e-01	0.008
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.830617e-01	0.007
GDP-fucose biosynthesis	R-HSA-6787639	9.830617e-01	0.007
Choline catabolism	R-HSA-6798163	9.830617e-01	0.007
Transferrin endocytosis and recycling	R-HSA-917977	9.837780e-01	0.007
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.843245e-01	0.007
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	9.843245e-01	0.007
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.843245e-01	0.007
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.843245e-01	0.007
Synthesis of PE	R-HSA-1483213	9.843245e-01	0.007
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.859296e-01	0.006
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.859296e-01	0.006
Vitamin D (calciferol) metabolism	R-HSA-196791	9.859296e-01	0.006
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.859589e-01	0.006
Glycosphingolipid transport	R-HSA-9845576	9.859589e-01	0.006
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.862102e-01	0.006
Amine ligand-binding receptors	R-HSA-375280	9.866019e-01	0.006
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.868962e-01	0.006
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	9.883120e-01	0.005
Diseases of hemostasis	R-HSA-9671793	9.883120e-01	0.005
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.883120e-01	0.005
HDL remodeling	R-HSA-8964058	9.883120e-01	0.005
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.886216e-01	0.005
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.886216e-01	0.005
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.889634e-01	0.005
Role of phospholipids in phagocytosis	R-HSA-2029485	9.889634e-01	0.005
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.895065e-01	0.005
Interleukin-10 signaling	R-HSA-6783783	9.897271e-01	0.004
Integrin cell surface interactions	R-HSA-216083	9.897271e-01	0.004
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.902912e-01	0.004
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.902912e-01	0.004
Melanin biosynthesis	R-HSA-5662702	9.902912e-01	0.004
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.902912e-01	0.004
Acyl chain remodelling of PI	R-HSA-1482922	9.902912e-01	0.004
Synthesis of Ketone Bodies	R-HSA-77111	9.902912e-01	0.004
Pregnenolone biosynthesis	R-HSA-196108	9.902912e-01	0.004
Retinoid metabolism and transport	R-HSA-975634	9.905178e-01	0.004
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.912183e-01	0.004
Cargo concentration in the ER	R-HSA-5694530	9.917613e-01	0.004
Abacavir metabolism	R-HSA-2161541	9.919353e-01	0.004
Acyl chain remodelling of PG	R-HSA-1482925	9.919353e-01	0.004
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.921819e-01	0.003
Diseases of carbohydrate metabolism	R-HSA-5663084	9.925004e-01	0.003
Synthesis of PA	R-HSA-1483166	9.926975e-01	0.003
DAG1 glycosylations	R-HSA-8931838	9.929956e-01	0.003
HS-GAG degradation	R-HSA-2024096	9.929956e-01	0.003
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.932273e-01	0.003
Chemokine receptors bind chemokines	R-HSA-380108	9.932273e-01	0.003
Maturation of spike protein	R-HSA-9694548	9.932591e-01	0.003
Molybdenum cofactor biosynthesis	R-HSA-947581	9.933011e-01	0.003
Androgen biosynthesis	R-HSA-193048	9.933011e-01	0.003
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.933011e-01	0.003
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.940482e-01	0.003
Leishmania parasite growth and survival	R-HSA-9664433	9.943074e-01	0.002
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.943074e-01	0.002
Neurotransmitter release cycle	R-HSA-112310	9.943394e-01	0.002
Fructose metabolism	R-HSA-5652084	9.944356e-01	0.002
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.944356e-01	0.002
Cellular hexose transport	R-HSA-189200	9.944356e-01	0.002
Acyl chain remodelling of PC	R-HSA-1482788	9.949453e-01	0.002
Miscellaneous transport and binding events	R-HSA-5223345	9.949453e-01	0.002
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.949990e-01	0.002
Signaling by Retinoic Acid	R-HSA-5362517	9.950733e-01	0.002
Organic anion transport by SLCO transporters	R-HSA-879518	9.953781e-01	0.002
Free fatty acids regulate insulin secretion	R-HSA-400451	9.953781e-01	0.002
Ketone body metabolism	R-HSA-74182	9.953781e-01	0.002
Formation of the ureteric bud	R-HSA-9830674	9.953781e-01	0.002
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.953781e-01	0.002
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.953781e-01	0.002
ABC transporters in lipid homeostasis	R-HSA-1369062	9.953781e-01	0.002
Phospholipid metabolism	R-HSA-1483257	9.956438e-01	0.002
RA biosynthesis pathway	R-HSA-5365859	9.957092e-01	0.002
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.957092e-01	0.002
SLC-mediated transport of organic anions	R-HSA-9955298	9.958815e-01	0.002
CYP2E1 reactions	R-HSA-211999	9.961610e-01	0.002
Mitochondrial RNA degradation	R-HSA-9836573	9.961610e-01	0.002
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.963544e-01	0.002
Acyl chain remodelling of PE	R-HSA-1482839	9.963595e-01	0.002
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.963595e-01	0.002
Complex I biogenesis	R-HSA-6799198	9.966974e-01	0.001
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.968113e-01	0.001
HS-GAG biosynthesis	R-HSA-2022928	9.969126e-01	0.001
Asparagine N-linked glycosylation	R-HSA-446203	9.971038e-01	0.001
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.971492e-01	0.001
Visual phototransduction	R-HSA-2187338	9.971921e-01	0.001
Urea cycle	R-HSA-70635	9.973514e-01	0.001
Sphingolipid catabolism	R-HSA-9845614	9.973514e-01	0.001
Abacavir ADME	R-HSA-2161522	9.973514e-01	0.001
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.973828e-01	0.001
Formation of the cornified envelope	R-HSA-6809371	9.977736e-01	0.001
Purine salvage	R-HSA-74217	9.977824e-01	0.001
Triglyceride biosynthesis	R-HSA-75109	9.978001e-01	0.001
Dectin-2 family	R-HSA-5621480	9.978107e-01	0.001
Kidney development	R-HSA-9830369	9.980802e-01	0.001
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.981217e-01	0.001
Iron assimilation using enterobactin	R-HSA-9638334	9.981728e-01	0.001
Prednisone ADME	R-HSA-9757110	9.981728e-01	0.001
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.983596e-01	0.001
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.984097e-01	0.001
Tryptophan catabolism	R-HSA-71240	9.984097e-01	0.001
Thyroxine biosynthesis	R-HSA-209968	9.984824e-01	0.001
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.984824e-01	0.001
G alpha (q) signalling events	R-HSA-416476	9.985771e-01	0.001
GABA receptor activation	R-HSA-977443	9.985812e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.987300e-01	0.001
Branched-chain amino acid catabolism	R-HSA-70895	9.987332e-01	0.001
ECM proteoglycans	R-HSA-3000178	9.988947e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.988947e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.991402e-01	0.000
Defective B3GALTL causes PpS	R-HSA-5083635	9.992779e-01	0.000
Methylation	R-HSA-156581	9.993118e-01	0.000
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.993118e-01	0.000
Paracetamol ADME	R-HSA-9753281	9.993210e-01	0.000
Glutamate and glutamine metabolism	R-HSA-8964539	9.994003e-01	0.000
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.994185e-01	0.000
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.995043e-01	0.000
FCGR activation	R-HSA-2029481	9.995233e-01	0.000
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.995863e-01	0.000
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.995863e-01	0.000
Plasma lipoprotein remodeling	R-HSA-8963899	9.996499e-01	0.000
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.997147e-01	0.000
Ubiquinol biosynthesis	R-HSA-2142789	9.997147e-01	0.000
SLC-mediated transport of organic cations	R-HSA-549127	9.997147e-01	0.000
Collagen chain trimerization	R-HSA-8948216	9.997147e-01	0.000
Metabolism of folate and pterines	R-HSA-196757	9.997147e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.997194e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.997221e-01	0.000
Collagen degradation	R-HSA-1442490	9.997369e-01	0.000
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.997631e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.997830e-01	0.000
Complex IV assembly	R-HSA-9864848	9.997897e-01	0.000
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.998032e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.998118e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.998370e-01	0.000
Xenobiotics	R-HSA-211981	9.998370e-01	0.000
Aflatoxin activation and detoxification	R-HSA-5423646	9.998643e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.998760e-01	0.000
PPARA activates gene expression	R-HSA-1989781	9.998882e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998994e-01	0.000
G alpha (s) signalling events	R-HSA-418555	9.999018e-01	0.000
Defensins	R-HSA-1461973	9.999223e-01	0.000
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.999223e-01	0.000
Surfactant metabolism	R-HSA-5683826	9.999355e-01	0.000
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.999355e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999379e-01	0.000
The canonical retinoid cycle in rods (twilight vision)	R-HSA-2453902	9.999464e-01	0.000
Degradation of cysteine and homocysteine	R-HSA-1614558	9.999464e-01	0.000
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.999466e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.999473e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999483e-01	0.000
Purine catabolism	R-HSA-74259	9.999552e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.999590e-01	0.000
Aspirin ADME	R-HSA-9749641	9.999620e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.999622e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999628e-01	0.000
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.999630e-01	0.000
Collagen formation	R-HSA-1474290	9.999705e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999726e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999728e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999784e-01	0.000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.999788e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999822e-01	0.000
Cytosolic sulfonation of small molecules	R-HSA-156584	9.999824e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.999866e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.999866e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.999887e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999908e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.999931e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.999933e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999936e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999952e-01	0.000
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.999960e-01	0.000
Endogenous sterols	R-HSA-211976	9.999973e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.999980e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999984e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999984e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999988e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.999993e-01	0.000
Transport of small molecules	R-HSA-382551	9.999993e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999993e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999993e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999993e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.999995e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.999998e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999998e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999999e-01	0.000
Drug ADME	R-HSA-9748784	9.999999e-01	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Sulfur amino acid metabolism	R-HSA-1614635	1.000000e+00	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	1.000000e+00	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Scavenging of heme from plasma	R-HSA-2168880	1.000000e+00	0.000
Mitochondrial translation elongation	R-HSA-5389840	1.000000e+00	0.000
Mitochondrial translation initiation	R-HSA-5368286	1.000000e+00	0.000
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Mitochondrial translation termination	R-HSA-5419276	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	-0.000