HASPIN

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
O15371	T49	Sugiyama	EIF3D EIF3S7	PyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGGSQY
O43390	T137	Sugiyama	HNRNPR HNRPR	ESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O60506	T134	Sugiyama	SYNCRIP HNRPQ NSAP1	DSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O95218	S181	Sugiyama	ZRANB2 ZIS ZNF265	DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
P00558	T168	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P02545	S583	Sugiyama	LMNA LMN1	HHHHGsHCsssGDPAEYNLRsRtVLCGtCGQPADKAsAsGs
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P07205	T168	Sugiyama	PGK2 PGKB	EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P13639	S593	Sugiyama	EEF2 EF2	SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P15880	T202	Sugiyama	RPS2 RPS4	CKVTGRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDC
P15880	T232	Sugiyama	RPS2 RPS4	KLLMMAGIDDCytsARGCtAtLGNFAKATFDAISKTysyLt
P15880	T278	Sugiyama	RPS2 RPS4	EtVFtKsPyQEFtDHLVKtHtRVsVQRtQAPAVATt_____
P15880	T285	Sugiyama	RPS2 RPS4	PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P17812	S574	Sugiyama	CTPS1 CTPS	YLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD___
P18077	Y14	Sugiyama	RPL35A GIG33	_______MSGRLWSKAIFAGyKRGLRNQREHTALLKIEGVy
P18124	T17	Sugiyama	RPL7	____MEGVEEKKKEVPAVPEtLKKKRRNFAELKIKRLRKKF
P18583	S2011	Sugiyama	SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312	RSRTPSRRRRSRSVVRRRsFsIsPVRLRRSRTPLRRRFsRs
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P19338	S458	Sugiyama	NCL	TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P20618	S157	Sugiyama	PSMB1 PSC5	IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P22090	S204	Sugiyama	RPS4Y1 RPS4Y PRO2646	IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22626	S351	Sugiyama	HNRNPA2B1 HNRPA2B1	yGGGNyGPGGsGGsGGyGGRsRy__________________
P22626	Y347	Sugiyama	HNRNPA2B1 HNRPA2B1	MGGPyGGGNyGPGGsGGsGGyGGRsRy______________
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P35268	T62	Sugiyama	RPL22	FLQERIKVNGKAGNLGGGVVtIERsKSKITVTSEVPFSKRY
P36578	S87	Sugiyama	RPL4 RPL1	WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578	T69	Sugiyama	RPL4 RPL1	RQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHRsGQ
P36578	T84	Sugiyama	RPL4 RPL1	AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P37108	T45	Sugiyama	SRP14	sVyItLKKYDGRTKPIPKKGtVEGFEPADNKCLLRATDGKK
P38646	T120	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646	T86	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P42677	S78	Sugiyama	RPS27 MPS1	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P46778	T124	Sugiyama	RPL21	sFLKRVKENDQKKKEAKEKGtWVQLKRQPAPPREAHFVRTN
P46778	T29	Sugiyama	RPL21	RGTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQ
P46779	T81	Sugiyama	RPL28	VVVIKRRSGQRKPAtsyVRttINKNARAtLsSIRHMIRKNK
P46783	T148	Sugiyama	RPS10	RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___
P47914	T151	Sugiyama	RPL29	DQTKAQAAAPAsVPAQAPKRtQAPtKAsE____________
P47914	T155	Sugiyama	RPL29	AQAAAPAsVPAQAPKRtQAPtKAsE________________
P50914	T43	Sugiyama	RPL14	KLVAIVDVIDQNRALVDGPCtQVRRQAMPFKCMQLTDFILK
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P61313	S97	Sugiyama	RPL15 EC45 TCBAP0781	KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61313	Y6	Sugiyama	RPL15 EC45 TCBAP0781	_______________MGAYKyIQELWRKKQSDVMRFLLRVR
P61353	S39	Sugiyama	RPL27	SGRKAVIVKNIDDGtsDRPysHALVAGIDRyPRKVTAAMGK
P61513	T16	Sugiyama	RPL37A	_____MAKRTKKVGIVGKyGtRYGAsLRKMVKKIEISQHAK
P62081	T121	Sugiyama	RPS7	LPKPTRKSRTKNKQKRPRsRtLtAVHDAILEDLVFPsEIVG
P62081	T123	Sugiyama	RPS7	KPTRKSRTKNKQKRPRsRtLtAVHDAILEDLVFPsEIVGKR
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263	S139	Sugiyama	RPS14 PRO2640	LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62263	T140	Sugiyama	RPS14 PRO2640	ARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL_________
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62701	S204	Sugiyama	RPS4X CCG2 RPS4 SCAR	tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62750	T42	Sugiyama	RPL23A	LKAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPR
P62899	S15	Sugiyama	RPL31	______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899	T26	Sugiyama	RPL31	KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62910	S105	Sugiyama	RPL32 PP9932	LEVLLMCNKsyCAEIAHNVSsKNRKAIVERAAQLAIRVTNP
P62917	S14	Sugiyama	RPL8	_______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917	T135	Sugiyama	RPL8	CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917	T143	Sugiyama	RPL8	RGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANR
P62917	T146	Sugiyama	RPL8	LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809	S136	Sugiyama	YBX1 NSEP1 YB1	GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809	Y196	Sugiyama	YBX1 NSEP1 YB1	sAPEGQAQQRRPyRRRRFPPyyMRRPYGRRPQysNPPVQGE
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68431	T4	GPS6\|SIGNOR\|EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	_________________MARtKQtARKstGGKAPRKQLATK
P83731	T52	Sugiyama	RPL24	LNAKCEsAFLSKRNPRQINWtVLyRRKHKKGQsEEIQKKRT
P83731	Y55	Sugiyama	RPL24	KCEsAFLSKRNPRQINWtVLyRRKHKKGQsEEIQKKRTRRA
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84243	T4	GPS6\|EPSD	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	_________________MARtKQTARKstGGKAPRKQLATK
Q00059	S160	Sugiyama	TFAM TCF6 TCF6L2	RKAMTKKKELTLLGKPKRPRsAYNVyVAERFQEAKGDsPQE
Q01105	S168	Sugiyama	SET	ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q02543	S123	Sugiyama	RPL18A	AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q04695	T410	Sugiyama	KRT17	GEDAHLTQyKKEPVTTRQVRtIVEEVQDGKVISSREQVHQT
Q07020	T136	Sugiyama	RPL18	AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020	T85	Sugiyama	RPL18	RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q13263	S471	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	FGsGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLE
Q13442	S63	Sugiyama	PDAP1 HASPP28	GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q16181	T426	Sugiyama	SEPTIN7 CDC10 SEPT7	DEKANWEAQQRILEQQNssRtLEKNKKKGKIF_________
Q16695	T4	GPS6	H3-4 H3FT HIST3H3	_________________MARtKQTARKsTGGKAPRKQLATK
Q71DI3	T4	GPS6\|EPSD	H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D	_________________MARtKQTARKsTGGKAPRKQLATK
Q71UM5	S78	Sugiyama	RPS27L	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q86V81	S145	Sugiyama	ALYREF ALY BEF THOC4	LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q8TF76	S108	Sugiyama	HASPIN GSG2	PKDRPsLTVtPKRWKLRARPsLtVtPRRLGLRARPPQKCSt
Q8TF76	S147	Sugiyama	HASPIN GSG2	StPCGPLRLPPFPsRDsGRLsPDLsVCGQPRDGDELGIsAS
Q8TF76	S151	Sugiyama	HASPIN GSG2	GPLRLPPFPsRDsGRLsPDLsVCGQPRDGDELGIsASLFSS
Q8TF76	S288	Sugiyama	HASPIN GSG2	EsCCKRKLVVGNGPEGPGLsstGKRRAtGQDSCQERGLQEA
Q8TF76	S349	Sugiyama	HASPIN GSG2	DRLERTRSSRKSKHQEATEtsLLHsHRFKKGQKLGKDsFPT
Q8TF76	S353	Sugiyama	HASPIN GSG2	RTRSSRKSKHQEATEtsLLHsHRFKKGQKLGKDsFPTQDLt
Q8TF76	S389	Sugiyama	HASPIN GSG2	TQDLtPLQNVCFWTKTRAsFsFHKKKIVTDVSEVCSIYTTA
Q8TF76	S543	Sugiyama	HASPIN GSG2	GSHQKTFEEILPEIIISKELsLLSGEVCNRTEGFIGLNSVH
Q8TF76	T128	Sugiyama	HASPIN GSG2	sLtVtPRRLGLRARPPQKCStPCGPLRLPPFPsRDsGRLsP
Q8TF76	T15	Sugiyama	HASPIN GSG2	______MAAsLPGPGsRLFRtyGAADGRRQRRPGREAAQWF
Q8TF76	T289	Sugiyama	HASPIN GSG2	sCCKRKLVVGNGPEGPGLsstGKRRAtGQDSCQERGLQEAV
Q8TF76	Y16	Sugiyama	HASPIN GSG2	_____MAAsLPGPGsRLFRtyGAADGRRQRRPGREAAQWFP
Q92522	T55	Sugiyama	H1-10 H1FX	KRKNSKKKNQPGKySQLVVEtIRRLGERNGSSLAKIYTEAK
Q92882	T200	Sugiyama	OSTF1	ATNAACAsLLKKKQGTDAVRtLsNAEDyLDDEDsD______
Q99543	T268	Sugiyama	DNAJC2 MPHOSPH11 MPP11 ZRF1	EKQNRATRAQRKKEEMNRIRtLVDNAysCDPRIKKFKEEEK
Q99613	T880	Sugiyama	EIF3C EIF3S8	AEKLGsLVENNERVFDHKQGtyGGyFRDQKDGYRKNEGYMR
Q9BQ69	T196	Sugiyama	MACROD1 LRP16	SLLGGGGVDGCIHRAAGPLLtDECRtLQSCKTGKAKITGGY
Q9BQ69	T201	Sugiyama	MACROD1 LRP16	GGVDGCIHRAAGPLLtDECRtLQSCKTGKAKITGGYRLPAK
Q9H0H5	S206	Sugiyama	RACGAP1 KIAA1478 MGCRACGAP	tsRQFVDGPPGPVKKtRsIGsAVDQGNEsIVAKTTVTVPND
Q9H0H5	T251	Sugiyama	RACGAP1 KIAA1478 MGCRACGAP	EAVSTIETVPYWtRSRRKtGtLQPWNsDstLNSRQLEPRTE
Q9NQ39	T159	Sugiyama	RPS10P5 RPS10L	RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___
Q9NZB2	T991	Sugiyama	FAM120A C9orf10 KIAA0183 OSSA	PLQVVSVGGPARGRPRGVIstPVIRTFGRGGRYYGRGYKNQ
Q9P258	T521	Sugiyama	RCC2 KIAA1470 TD60	RDESETEKEKIKKLPEYNPRtL___________________
Q9UGV2	S327	Sugiyama	NDRG3	KYFLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsV
Q9UGV2	T329	Sugiyama	NDRG3	FLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVts
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35	S2102	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	GSSSDRSRsAtPPATRNHsGsRtPPVALNsSRMsCFsRPsM
Q9Y2V2	T50	Sugiyama	CARHSP1	sPsPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCF
Q9Y2X3	S440	Sugiyama	NOP58 NOL5 NOP5 HSPC120	EHKSEVKtyDPSGDstLPtCsKKRKIEQVDKEDEITEKKAK
Q9Y388	S227	Sugiyama	RBMX2 CGI-79	SKNSERAQKSEPREGQKLPKsRTAYsGGAEDLERELKKEKP
Q9Y3U8	Y53	Sugiyama	RPL36	LTKHTKFVRDMIREVCGFAPyERRAMELLKVSKDKRALKFI

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.190327e-09	8.924
Cell Cycle	R-HSA-1640170	1.142242e-09	8.942
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.104844e-09	8.677
Mitotic Prometaphase	R-HSA-68877	1.749517e-09	8.757
Cell Cycle, Mitotic	R-HSA-69278	2.388514e-09	8.622
M Phase	R-HSA-68886	2.855665e-08	7.544
Axon guidance	R-HSA-422475	2.603845e-08	7.584
Nervous system development	R-HSA-9675108	3.622829e-08	7.441
Amplification of signal from the kinetochores	R-HSA-141424	2.294046e-07	6.639
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.294046e-07	6.639
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.433944e-07	6.614
Mitotic Anaphase	R-HSA-68882	2.230503e-07	6.652
Separation of Sister Chromatids	R-HSA-2467813	5.763339e-07	6.239
Mitotic Spindle Checkpoint	R-HSA-69618	2.351650e-06	5.629
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.712458e-06	5.567
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.356275e-06	5.474
Metabolism of RNA	R-HSA-8953854	7.470189e-06	5.127
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.526471e-05	4.816
Post NMDA receptor activation events	R-HSA-438064	2.437127e-05	4.613
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.738986e-05	4.562
Signal Transduction	R-HSA-162582	3.580009e-05	4.446
Cell Cycle Checkpoints	R-HSA-69620	3.894182e-05	4.410
G2/M Transition	R-HSA-69275	3.879383e-05	4.411
Mitotic G2-G2/M phases	R-HSA-453274	4.483870e-05	4.348
PKMTs methylate histone lysines	R-HSA-3214841	5.478049e-05	4.261
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	6.391151e-05	4.194
Signaling by ERBB2 ECD mutants	R-HSA-9665348	7.309837e-05	4.136
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	7.574023e-05	4.121
Semaphorin interactions	R-HSA-373755	7.495848e-05	4.125
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.218149e-04	3.914
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.330433e-04	3.876
Cilium Assembly	R-HSA-5617833	1.391088e-04	3.857
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.435875e-04	3.843
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.458446e-04	3.836
mRNA Splicing - Major Pathway	R-HSA-72163	1.805185e-04	3.743
Kinesins	R-HSA-983189	2.140624e-04	3.669
Aggrephagy	R-HSA-9646399	2.368467e-04	3.626
RNA Polymerase II Transcription Termination	R-HSA-73856	2.420215e-04	3.616
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.514934e-04	3.599
Signaling by ALK in cancer	R-HSA-9700206	2.514934e-04	3.599
Mitotic Prophase	R-HSA-68875	2.874307e-04	3.541
ISG15 antiviral mechanism	R-HSA-1169408	3.091863e-04	3.510
mRNA 3'-end processing	R-HSA-72187	3.248328e-04	3.488
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.198911e-04	3.495
mRNA Splicing	R-HSA-72172	3.555262e-04	3.449
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.913290e-04	3.407
Constitutive Signaling by EGFRvIII	R-HSA-5637810	4.244091e-04	3.372
Signaling by EGFRvIII in Cancer	R-HSA-5637812	4.244091e-04	3.372
Sema4D in semaphorin signaling	R-HSA-400685	4.413905e-04	3.355
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	4.244091e-04	3.372
NRAGE signals death through JNK	R-HSA-193648	5.330859e-04	3.273
Transport of connexons to the plasma membrane	R-HSA-190872	5.347134e-04	3.272
Nuclear Envelope Breakdown	R-HSA-2980766	5.995981e-04	3.222
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.043285e-04	3.219
Signaling by NTRK2 (TRKB)	R-HSA-9006115	6.358635e-04	3.197
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	6.996085e-04	3.155
SHC-related events triggered by IGF1R	R-HSA-2428933	6.996085e-04	3.155
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.352629e-04	3.134
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	8.211918e-04	3.086
Signaling by ERBB2 KD Mutants	R-HSA-9664565	8.928145e-04	3.049
SOS-mediated signalling	R-HSA-112412	9.821458e-04	3.008
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.002743e-03	2.999
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.002743e-03	2.999
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.048765e-03	2.979
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.048765e-03	2.979
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.043411e-03	2.982
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.099351e-03	2.959
AURKA Activation by TPX2	R-HSA-8854518	1.566449e-03	2.805
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.641767e-03	2.785
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.647811e-03	2.783
L1CAM interactions	R-HSA-373760	1.752495e-03	2.756
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.898192e-03	2.722
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.866562e-03	2.729
Organelle biogenesis and maintenance	R-HSA-1852241	1.931803e-03	2.714
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.053021e-03	2.688
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	2.053021e-03	2.688
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.055270e-03	2.687
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.291186e-03	2.640
Cellular responses to stress	R-HSA-2262752	2.419017e-03	2.616
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.484258e-03	2.605
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	2.537478e-03	2.596
Apoptotic execution phase	R-HSA-75153	2.583779e-03	2.588
Signaling by EGFR in Cancer	R-HSA-1643713	2.817127e-03	2.550
RET signaling	R-HSA-8853659	2.825440e-03	2.549
Recycling pathway of L1	R-HSA-437239	2.885048e-03	2.540
Estrogen-dependent gene expression	R-HSA-9018519	2.960568e-03	2.529
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	2.979853e-03	2.526
Signaling by ERBB2	R-HSA-1227986	3.020432e-03	2.520
Activated NTRK3 signals through RAS	R-HSA-9034864	3.301183e-03	2.481
p75 NTR receptor-mediated signalling	R-HSA-193704	3.267763e-03	2.486
Polo-like kinase mediated events	R-HSA-156711	3.369815e-03	2.472
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	3.444927e-03	2.463
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	3.444927e-03	2.463
Diseases of Telomere Maintenance	R-HSA-9673013	3.444927e-03	2.463
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	3.444927e-03	2.463
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	3.444927e-03	2.463
Selective autophagy	R-HSA-9663891	3.576270e-03	2.447
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.988519e-03	2.399
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.988519e-03	2.399
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.066752e-03	2.391
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.066752e-03	2.391
Activated NTRK2 signals through RAS	R-HSA-9026519	4.207978e-03	2.376
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	4.153711e-03	2.382
Downstream signaling of activated FGFR3	R-HSA-5654708	4.337918e-03	2.363
IGF1R signaling cascade	R-HSA-2428924	4.360092e-03	2.361
ESR-mediated signaling	R-HSA-8939211	4.259069e-03	2.371
G alpha (12/13) signalling events	R-HSA-416482	4.504615e-03	2.346
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.758110e-03	2.323
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	4.948786e-03	2.306
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	4.958749e-03	2.305
Downstream signaling of activated FGFR4	R-HSA-5654716	4.958749e-03	2.305
PKR-mediated signaling	R-HSA-9833482	5.263630e-03	2.279
Signaling by LTK	R-HSA-9842663	5.269410e-03	2.278
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	5.642427e-03	2.249
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	5.642427e-03	2.249
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	5.642427e-03	2.249
Cellular responses to stimuli	R-HSA-8953897	6.260424e-03	2.203
Apoptotic cleavage of cellular proteins	R-HSA-111465	6.392493e-03	2.194
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	6.546406e-03	2.184
Signaling by NTRK3 (TRKC)	R-HSA-9034015	6.546406e-03	2.184
Signaling by EGFR	R-HSA-177929	6.989766e-03	2.156
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	7.079503e-03	2.150
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	7.099302e-03	2.149
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	7.212470e-03	2.142
IPs transport between nucleus and cytosol	R-HSA-1855170	7.212470e-03	2.142
Signaling by FGFR4 in disease	R-HSA-5655291	7.899281e-03	2.102
Chromatin modifying enzymes	R-HSA-3247509	7.634485e-03	2.117
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	7.244022e-03	2.140
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	7.212470e-03	2.142
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	8.105855e-03	2.091
Nonsense-Mediated Decay (NMD)	R-HSA-927802	8.131713e-03	2.090
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	8.131713e-03	2.090
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	8.310119e-03	2.080
Death Receptor Signaling	R-HSA-73887	8.310119e-03	2.080
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.727229e-03	2.059
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	9.045311e-03	2.044
Nuclear import of Rev protein	R-HSA-180746	9.076102e-03	2.042
Gap junction assembly	R-HSA-190861	9.076102e-03	2.042
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	9.438774e-03	2.025
Erythropoietin activates RAS	R-HSA-9027284	9.487554e-03	2.023
SHC1 events in EGFR signaling	R-HSA-180336	9.487554e-03	2.023
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.012662e-02	1.995
Downstream signaling of activated FGFR2	R-HSA-5654696	1.012662e-02	1.995
Downstream signaling of activated FGFR1	R-HSA-5654687	1.012662e-02	1.995
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.026888e-02	1.988
Centrosome maturation	R-HSA-380287	1.047095e-02	1.980
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.076776e-02	1.968
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.126766e-02	1.948
Intraflagellar transport	R-HSA-5620924	1.126766e-02	1.948
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.302667e-02	1.885
Regulation of TP53 Expression	R-HSA-6804754	1.302667e-02	1.885
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.302667e-02	1.885
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.302667e-02	1.885
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.302667e-02	1.885
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.302667e-02	1.885
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.302667e-02	1.885
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.302667e-02	1.885
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.302667e-02	1.885
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.302667e-02	1.885
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.302667e-02	1.885
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.302667e-02	1.885
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.302667e-02	1.885
HCMV Early Events	R-HSA-9609690	1.271961e-02	1.896
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	1.217733e-02	1.914
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.248173e-02	1.904
rRNA modification in the nucleus and cytosol	R-HSA-6790901	1.244675e-02	1.905
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.258211e-02	1.900
Influenza Infection	R-HSA-168255	1.276486e-02	1.894
GRB2 events in ERBB2 signaling	R-HSA-1963640	1.325475e-02	1.878
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.325475e-02	1.878
Chromatin organization	R-HSA-4839726	1.350033e-02	1.870
EPH-Ephrin signaling	R-HSA-2682334	1.373613e-02	1.862
Protein folding	R-HSA-391251	1.373613e-02	1.862
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.379277e-02	1.860
rRNA processing	R-HSA-72312	1.384538e-02	1.859
Cellular response to heat stress	R-HSA-3371556	1.494692e-02	1.825
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.532524e-02	1.815
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.577607e-02	1.802
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.577607e-02	1.802
Interactions of Rev with host cellular proteins	R-HSA-177243	1.669728e-02	1.777
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.669728e-02	1.777
Signaling by Erythropoietin	R-HSA-9006335	1.823189e-02	1.739
Signal attenuation	R-HSA-74749	1.888925e-02	1.724
EGFR Transactivation by Gastrin	R-HSA-2179392	1.888925e-02	1.724
Signaling by FGFR1 in disease	R-HSA-5655302	1.999769e-02	1.699
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.888925e-02	1.724
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	2.003824e-02	1.698
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.829661e-02	1.738
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.049031e-02	1.688
SARS-CoV-2-host interactions	R-HSA-9705683	2.268665e-02	1.644
Gene expression (Transcription)	R-HSA-74160	2.363622e-02	1.626
Signaling by FGFR4	R-HSA-5654743	2.371551e-02	1.625
TBC/RABGAPs	R-HSA-8854214	2.371551e-02	1.625
Chaperonin-mediated protein folding	R-HSA-390466	2.416225e-02	1.617
Muscle contraction	R-HSA-397014	2.428500e-02	1.615
Epigenetic regulation of gene expression	R-HSA-212165	2.491716e-02	1.604
Transmission across Chemical Synapses	R-HSA-112315	2.491716e-02	1.604
Gap junction trafficking	R-HSA-190828	2.573710e-02	1.589
Cap-dependent Translation Initiation	R-HSA-72737	2.629839e-02	1.580
Eukaryotic Translation Initiation	R-HSA-72613	2.629839e-02	1.580
SHC-mediated cascade:FGFR3	R-HSA-5654704	2.643564e-02	1.578
Signaling by Nuclear Receptors	R-HSA-9006931	2.648162e-02	1.577
Signaling by ERBB4	R-HSA-1236394	2.652755e-02	1.576
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	2.771954e-02	1.557
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.771954e-02	1.557
Signaling by AXIN mutants	R-HSA-4839735	2.727692e-02	1.564
SHC-mediated cascade:FGFR4	R-HSA-5654719	2.975669e-02	1.526
Condensation of Prophase Chromosomes	R-HSA-2299718	3.011668e-02	1.521
Metabolism of non-coding RNA	R-HSA-194441	2.676420e-02	1.572
snRNP Assembly	R-HSA-191859	2.676420e-02	1.572
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.184014e-02	1.497
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.727692e-02	1.564
RUNX3 regulates p14-ARF	R-HSA-8951936	3.209948e-02	1.494
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	3.209948e-02	1.494
GRB2 events in EGFR signaling	R-HSA-179812	3.209948e-02	1.494
MET activates RAS signaling	R-HSA-8851805	3.209948e-02	1.494
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.975669e-02	1.526
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.787014e-02	1.555
Signaling by FGFR3	R-HSA-5654741	2.787014e-02	1.555
MAPK family signaling cascades	R-HSA-5683057	2.870533e-02	1.542
RAB geranylgeranylation	R-HSA-8873719	2.865934e-02	1.543
Golgi-to-ER retrograde transport	R-HSA-8856688	2.778069e-02	1.556
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.011668e-02	1.521
Miscellaneous transport and binding events	R-HSA-5223345	3.000713e-02	1.523
Transcriptional Regulation by MECP2	R-HSA-8986944	3.018452e-02	1.520
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	3.247862e-02	1.488
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	3.271733e-02	1.485
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.331343e-02	1.477
mTORC1-mediated signalling	R-HSA-166208	3.331343e-02	1.477
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	3.331343e-02	1.477
Signaling by KIT in disease	R-HSA-9669938	3.331343e-02	1.477
Membrane Trafficking	R-HSA-199991	3.359086e-02	1.474
Signalling to ERKs	R-HSA-187687	3.579989e-02	1.446
MHC class II antigen presentation	R-HSA-2132295	3.619554e-02	1.441
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	3.669709e-02	1.435
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	3.669709e-02	1.435
IRS activation	R-HSA-74713	3.669709e-02	1.435
NrCAM interactions	R-HSA-447038	3.669709e-02	1.435
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	3.710750e-02	1.431
Insulin receptor signalling cascade	R-HSA-74751	3.714182e-02	1.430
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	3.733649e-02	1.428
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	3.733649e-02	1.428
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.733649e-02	1.428
Gap junction trafficking and regulation	R-HSA-157858	3.755557e-02	1.425
Autophagy	R-HSA-9612973	3.943609e-02	1.404
SHC-mediated cascade:FGFR1	R-HSA-5654688	4.113980e-02	1.386
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.113980e-02	1.386
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	4.182638e-02	1.379
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	4.182638e-02	1.379
Loss of Function of TP53 in Cancer	R-HSA-9723907	4.182638e-02	1.379
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	4.182638e-02	1.379
Macroautophagy	R-HSA-1632852	4.205929e-02	1.376
Inositol phosphate metabolism	R-HSA-1483249	4.331360e-02	1.363
Phosphorylation of Emi1	R-HSA-176417	4.662432e-02	1.331
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	4.902781e-02	1.310
Translation initiation complex formation	R-HSA-72649	5.236968e-02	1.281
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	4.712931e-02	1.327
Sema3A PAK dependent Axon repulsion	R-HSA-399954	4.902781e-02	1.310
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	4.569982e-02	1.340
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.932730e-02	1.307
RAF/MAP kinase cascade	R-HSA-5673001	4.675475e-02	1.330
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	5.311955e-02	1.275
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	5.311955e-02	1.275
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.521571e-02	1.345
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	4.902781e-02	1.310
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	4.902781e-02	1.310
Signaling by ALK	R-HSA-201556	4.932730e-02	1.307
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	5.295861e-02	1.276
XBP1(S) activates chaperone genes	R-HSA-381038	5.417579e-02	1.266
Adipogenesis	R-HSA-9843745	5.447762e-02	1.264
SHC-mediated cascade:FGFR2	R-HSA-5654699	5.466469e-02	1.262
EPHA-mediated growth cone collapse	R-HSA-3928663	5.466469e-02	1.262
Signaling by FGFR3 in disease	R-HSA-5655332	5.466469e-02	1.262
MAPK1/MAPK3 signaling	R-HSA-5684996	5.607743e-02	1.251
Signaling by NTRKs	R-HSA-166520	5.667012e-02	1.247
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	5.740632e-02	1.241
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.740632e-02	1.241
Signaling by ROBO receptors	R-HSA-376176	5.806432e-02	1.236
Ribosomal scanning and start codon recognition	R-HSA-72702	5.916324e-02	1.228
Signaling by FGFR1	R-HSA-5654736	5.916324e-02	1.228
Peptide chain elongation	R-HSA-156902	5.962542e-02	1.225
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	6.228250e-02	1.206
SHC1 events in ERBB4 signaling	R-HSA-1250347	6.228250e-02	1.206
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.228250e-02	1.206
IRS-mediated signalling	R-HSA-112399	6.274798e-02	1.202
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	6.485855e-02	1.188
MTOR signalling	R-HSA-165159	6.548488e-02	1.184
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	6.645817e-02	1.177
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	6.842555e-02	1.165
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.895445e-02	1.161
RUNX3 regulates WNT signaling	R-HSA-8951430	6.895445e-02	1.161
MECP2 regulates transcription factors	R-HSA-9022707	6.895445e-02	1.161
Uptake and function of diphtheria toxin	R-HSA-5336415	6.895445e-02	1.161
PI3K events in ERBB2 signaling	R-HSA-1963642	6.946872e-02	1.158
Signaling by Hippo	R-HSA-2028269	6.946872e-02	1.158
Interferon Signaling	R-HSA-913531	6.948739e-02	1.158
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	7.029373e-02	1.153
DAP12 signaling	R-HSA-2424491	7.030172e-02	1.153
IRE1alpha activates chaperones	R-HSA-381070	7.152694e-02	1.146
Eukaryotic Translation Elongation	R-HSA-156842	7.471260e-02	1.127
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	8.190575e-02	1.087
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	8.190575e-02	1.087
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	9.310706e-02	1.031
Signaling by RAS mutants	R-HSA-6802949	8.425419e-02	1.074
Signaling downstream of RAS mutants	R-HSA-9649948	8.425419e-02	1.074
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	8.425419e-02	1.074
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	8.425419e-02	1.074
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	8.477550e-02	1.072
Formation of a pool of free 40S subunits	R-HSA-72689	8.829816e-02	1.054
Specification of the neural plate border	R-HSA-9834899	8.489498e-02	1.071
VxPx cargo-targeting to cilium	R-HSA-5620916	9.310706e-02	1.031
Chaperone Mediated Autophagy	R-HSA-9613829	7.701076e-02	1.113
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.190469e-02	1.037
Regulation of TP53 Activity	R-HSA-5633007	8.438123e-02	1.074
Regulation of TP53 Activity through Methylation	R-HSA-6804760	7.701076e-02	1.113
Eukaryotic Translation Termination	R-HSA-72764	8.829816e-02	1.054
IRS-related events triggered by IGF1R	R-HSA-2428928	7.833975e-02	1.106
HCMV Infection	R-HSA-9609646	7.629830e-02	1.117
Inhibition of PKR	R-HSA-169131	8.190575e-02	1.087
Activation of RAS in B cells	R-HSA-1169092	8.118596e-02	1.091
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	9.402367e-02	1.027
Ephrin signaling	R-HSA-3928664	7.701076e-02	1.113
Rap1 signalling	R-HSA-392517	8.489498e-02	1.071
Viral Messenger RNA Synthesis	R-HSA-168325	7.833975e-02	1.106
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.006115e-01	0.997
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	8.688209e-02	1.061
Signaling by PTK6	R-HSA-8848021	8.688209e-02	1.061
Regulation of MECP2 expression and activity	R-HSA-9022692	8.797410e-02	1.056
Cellular Senescence	R-HSA-2559583	8.973905e-02	1.047
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.797410e-02	1.056
Transcriptional regulation by RUNX3	R-HSA-8878159	9.559480e-02	1.020
Respiratory syncytial virus genome replication	R-HSA-9834752	9.402367e-02	1.027
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	8.797410e-02	1.056
Tie2 Signaling	R-HSA-210993	7.701076e-02	1.113
tRNA processing in the nucleus	R-HSA-6784531	8.254922e-02	1.083
Unfolded Protein Response (UPR)	R-HSA-381119	7.547256e-02	1.122
SARS-CoV-2 Infection	R-HSA-9694516	7.721024e-02	1.112
RAF activation	R-HSA-5673000	1.008305e-01	0.996
MyD88 deficiency (TLR2/4)	R-HSA-5602498	1.016321e-01	0.993
Signalling to RAS	R-HSA-167044	1.016321e-01	0.993
DNA Double Strand Break Response	R-HSA-5693606	1.054277e-01	0.977
Hedgehog 'off' state	R-HSA-5610787	1.071627e-01	0.970
Glycolysis	R-HSA-70171	1.071627e-01	0.970
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.073956e-01	0.969
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	1.073956e-01	0.969
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	1.073956e-01	0.969
PI3K/AKT activation	R-HSA-198203	1.073956e-01	0.969
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	1.073956e-01	0.969
Apoptosis induced DNA fragmentation	R-HSA-140342	1.073956e-01	0.969
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	1.073956e-01	0.969
Signaling by Leptin	R-HSA-2586552	1.073956e-01	0.969
Oncogene Induced Senescence	R-HSA-2559585	1.075658e-01	0.968
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.104549e-01	0.957
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	1.104549e-01	0.957
FRS-mediated FGFR3 signaling	R-HSA-5654706	1.104549e-01	0.957
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.104549e-01	0.957
Signaling by PDGFR in disease	R-HSA-9671555	1.104549e-01	0.957
Selenocysteine synthesis	R-HSA-2408557	1.111828e-01	0.954
HSF1-dependent transactivation	R-HSA-3371571	1.112469e-01	0.954
Regulation of TP53 Degradation	R-HSA-6804757	1.144982e-01	0.941
HSF1 activation	R-HSA-3371511	1.144982e-01	0.941
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.152841e-01	0.938
Formation of RNA Pol II elongation complex	R-HSA-112382	1.170933e-01	0.931
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.171072e-01	0.931
Viral mRNA Translation	R-HSA-192823	1.194658e-01	0.923
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.195598e-01	0.922
FRS-mediated FGFR4 signaling	R-HSA-5654712	1.195598e-01	0.922
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	1.203110e-01	0.920
Breakdown of the nuclear lamina	R-HSA-352238	1.203110e-01	0.920
DNA Double-Strand Break Repair	R-HSA-5693532	1.204987e-01	0.919
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.212349e-01	0.916
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.212349e-01	0.916
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.212349e-01	0.916
Formation of the posterior neural plate	R-HSA-9832991	1.212349e-01	0.916
Interleukin-2 signaling	R-HSA-9020558	1.212349e-01	0.916
Ionotropic activity of kainate receptors	R-HSA-451306	1.212349e-01	0.916
Signaling by APC mutants	R-HSA-4839744	1.212349e-01	0.916
Suppression of apoptosis	R-HSA-9635465	1.212349e-01	0.916
ChREBP activates metabolic gene expression	R-HSA-163765	1.212349e-01	0.916
Cytokine Signaling in Immune system	R-HSA-1280215	1.226404e-01	0.911
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.230823e-01	0.910
Smooth Muscle Contraction	R-HSA-445355	1.230823e-01	0.910
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.237272e-01	0.908
Defective PAPSS2 causes SEMD-PA	R-HSA-3560796	1.571119e-01	0.804
Signaling by RAS GAP mutants	R-HSA-9753510	1.571119e-01	0.804
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	1.571119e-01	0.804
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	1.571119e-01	0.804
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	1.571119e-01	0.804
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	1.571119e-01	0.804
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	1.923754e-01	0.716
MET activates PTPN11	R-HSA-8865999	1.923754e-01	0.716
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	1.923754e-01	0.716
Defective GCLC causes HAGGSD	R-HSA-5578999	1.923754e-01	0.716
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	1.923754e-01	0.716
Classical Kir channels	R-HSA-1296053	1.923754e-01	0.716
TNFR1-mediated ceramide production	R-HSA-5626978	2.261657e-01	0.646
Nucleotide catabolism defects	R-HSA-9735786	2.261657e-01	0.646
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	2.261657e-01	0.646
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.261657e-01	0.646
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.261657e-01	0.646
Signaling by MAP2K mutants	R-HSA-9652169	2.261657e-01	0.646
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.261657e-01	0.646
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.585442e-01	0.587
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	2.585442e-01	0.587
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.585442e-01	0.587
Signaling by GSK3beta mutants	R-HSA-5339716	1.354790e-01	0.868
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.500701e-01	0.824
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.500701e-01	0.824
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.500701e-01	0.824
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.500701e-01	0.824
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.500701e-01	0.824
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.500701e-01	0.824
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.500701e-01	0.824
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.895698e-01	0.538
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	2.895698e-01	0.538
IkBA variant leads to EDA-ID	R-HSA-5603029	2.895698e-01	0.538
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	2.895698e-01	0.538
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	2.895698e-01	0.538
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	1.800819e-01	0.745
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.192990e-01	0.496
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.192990e-01	0.496
Erythropoietin activates STAT5	R-HSA-9027283	3.192990e-01	0.496
Beta-catenin phosphorylation cascade	R-HSA-196299	1.954062e-01	0.709
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.954062e-01	0.709
Deadenylation of mRNA	R-HSA-429947	1.385525e-01	0.858
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.108846e-01	0.676
Phase 4 - resting membrane potential	R-HSA-5576886	2.108846e-01	0.676
MET activates PI3K/AKT signaling	R-HSA-8851907	3.477858e-01	0.459
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.264775e-01	0.645
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.264775e-01	0.645
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	3.750822e-01	0.426
Type I hemidesmosome assembly	R-HSA-446107	3.750822e-01	0.426
RSK activation	R-HSA-444257	3.750822e-01	0.426
EGFR interacts with phospholipase C-gamma	R-HSA-212718	3.750822e-01	0.426
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	3.750822e-01	0.426
Activated NTRK2 signals through PI3K	R-HSA-9028335	3.750822e-01	0.426
MET receptor recycling	R-HSA-8875656	3.750822e-01	0.426
GAB1 signalosome	R-HSA-180292	2.578630e-01	0.589
PI-3K cascade:FGFR3	R-HSA-5654710	2.735908e-01	0.563
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.735908e-01	0.563
PI-3K cascade:FGFR4	R-HSA-5654720	2.893031e-01	0.539
Diseases of mitotic cell cycle	R-HSA-9675126	2.226288e-01	0.652
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.049738e-01	0.516
Striated Muscle Contraction	R-HSA-390522	2.450581e-01	0.611
mRNA Splicing - Minor Pathway	R-HSA-72165	2.018702e-01	0.695
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.205788e-01	0.494
PI-3K cascade:FGFR1	R-HSA-5654689	3.360963e-01	0.474
Nuclear Receptor transcription pathway	R-HSA-383280	1.657598e-01	0.781
Interleukin receptor SHC signaling	R-HSA-912526	3.515063e-01	0.454
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.415523e-01	0.849
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.651896e-01	0.576
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.499515e-01	0.824
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.499515e-01	0.824
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.255117e-01	0.487
MAP2K and MAPK activation	R-HSA-5674135	3.486578e-01	0.458
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.499515e-01	0.824
Transcriptional regulation by RUNX1	R-HSA-8878171	2.579126e-01	0.589
Chromosome Maintenance	R-HSA-73886	2.240413e-01	0.650
EGFR downregulation	R-HSA-182971	2.115737e-01	0.675
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.139317e-01	0.503
G0 and Early G1	R-HSA-1538133	2.226288e-01	0.652
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.076644e-01	0.512
Oncogenic MAPK signaling	R-HSA-6802957	2.102668e-01	0.677
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	3.477858e-01	0.459
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.509484e-01	0.600
Signaling by RAF1 mutants	R-HSA-9656223	3.486578e-01	0.458
Attenuation phase	R-HSA-3371568	1.440733e-01	0.841
Ribosome-associated quality control	R-HSA-9948299	3.449427e-01	0.462
Activation of SMO	R-HSA-5635838	2.108846e-01	0.676
FRS-mediated FGFR1 signaling	R-HSA-5654693	1.484082e-01	0.829
FRS-mediated FGFR2 signaling	R-HSA-5654700	1.792212e-01	0.747
RAS processing	R-HSA-9648002	3.139317e-01	0.503
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.500701e-01	0.824
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	3.750822e-01	0.426
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.578630e-01	0.589
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	2.509484e-01	0.600
Regulation of mitotic cell cycle	R-HSA-453276	2.509484e-01	0.600
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.430634e-01	0.614
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.370905e-01	0.472
G alpha (q) signalling events	R-HSA-416476	2.386805e-01	0.622
Frs2-mediated activation	R-HSA-170968	1.649544e-01	0.783
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.585442e-01	0.587
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	3.477858e-01	0.459
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	3.750822e-01	0.426
TNFR1-induced proapoptotic signaling	R-HSA-5357786	3.049738e-01	0.516
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.908113e-01	0.536
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.312387e-01	0.882
Free fatty acids regulate insulin secretion	R-HSA-400451	3.515063e-01	0.454
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.483967e-01	0.829
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.261657e-01	0.646
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.261657e-01	0.646
Aryl hydrocarbon receptor signalling	R-HSA-8937144	2.895698e-01	0.538
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.385525e-01	0.858
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.264775e-01	0.645
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.584822e-01	0.800
Elevation of cytosolic Ca2+ levels	R-HSA-139853	2.421482e-01	0.616
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.360963e-01	0.474
G2/M DNA damage checkpoint	R-HSA-69473	1.423359e-01	0.847
Repression of WNT target genes	R-HSA-4641265	1.500701e-01	0.824
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.192990e-01	0.496
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.518950e-01	0.818
Downregulation of ERBB2 signaling	R-HSA-8863795	2.006441e-01	0.698
Clathrin-mediated endocytosis	R-HSA-8856828	2.545150e-01	0.594
Signaling by FGFR	R-HSA-190236	3.238982e-01	0.490
Signaling by WNT in cancer	R-HSA-4791275	2.226288e-01	0.652
Interleukin-2 family signaling	R-HSA-451927	3.255117e-01	0.487
Nuclear RNA decay	R-HSA-9930044	2.337950e-01	0.631
HDMs demethylate histones	R-HSA-3214842	1.484082e-01	0.829
Signaling by Insulin receptor	R-HSA-74752	1.505547e-01	0.822
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.749658e-01	0.561
Signaling by CSF3 (G-CSF)	R-HSA-9674555	1.898549e-01	0.722
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	1.571119e-01	0.804
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.923754e-01	0.716
Dopamine receptors	R-HSA-390651	2.261657e-01	0.646
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	2.261657e-01	0.646
Signaling by AMER1 mutants	R-HSA-4839748	1.354790e-01	0.868
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	2.895698e-01	0.538
G2/M DNA replication checkpoint	R-HSA-69478	3.192990e-01	0.496
Intracellular metabolism of fatty acids regulates insulin secretion	R-HSA-434313	3.192990e-01	0.496
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	2.108846e-01	0.676
Activated NTRK2 signals through CDK5	R-HSA-9032845	3.477858e-01	0.459
Disinhibition of SNARE formation	R-HSA-114516	3.477858e-01	0.459
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.578630e-01	0.589
Platelet calcium homeostasis	R-HSA-418360	1.898549e-01	0.722
Notch-HLH transcription pathway	R-HSA-350054	3.360963e-01	0.474
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	3.667906e-01	0.436
TRAF6 mediated NF-kB activation	R-HSA-933542	3.667906e-01	0.436
Deadenylation-dependent mRNA decay	R-HSA-429914	3.219472e-01	0.492
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.871245e-01	0.542
RNA Polymerase II Transcription	R-HSA-73857	1.279494e-01	0.893
Prolonged ERK activation events	R-HSA-169893	2.108846e-01	0.676
Interleukin-9 signaling	R-HSA-8985947	3.750822e-01	0.426
Signaling by FGFR2	R-HSA-5654738	1.780468e-01	0.749
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	3.602830e-01	0.443
Signaling by MET	R-HSA-6806834	1.780468e-01	0.749
Long-term potentiation	R-HSA-9620244	1.484082e-01	0.829
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	3.700495e-01	0.432
G1/S DNA Damage Checkpoints	R-HSA-69615	3.602830e-01	0.443
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.464472e-01	0.608
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.261657e-01	0.646
p38MAPK events	R-HSA-171007	1.954062e-01	0.709
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.477858e-01	0.459
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.477858e-01	0.459
GPER1 signaling	R-HSA-9634597	2.195102e-01	0.659
Regulation of RAS by GAPs	R-HSA-5658442	2.375409e-01	0.624
Regulation of PTEN gene transcription	R-HSA-8943724	3.315162e-01	0.479
Signaling by FGFR in disease	R-HSA-1226099	1.423359e-01	0.847
TCF dependent signaling in response to WNT	R-HSA-201681	3.637181e-01	0.439
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	2.128661e-01	0.672
Germ layer formation at gastrulation	R-HSA-9754189	2.735908e-01	0.563
UCH proteinases	R-HSA-5689603	2.912336e-01	0.536
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.297082e-01	0.639
Diseases associated with the TLR signaling cascade	R-HSA-5602358	1.440733e-01	0.841
Diseases of Immune System	R-HSA-5260271	1.440733e-01	0.841
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	2.128661e-01	0.672
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.106376e-01	0.676
Negative regulation of MAPK pathway	R-HSA-5675221	3.486578e-01	0.458
Ion transport by P-type ATPases	R-HSA-936837	3.698719e-01	0.432
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.297082e-01	0.639
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	1.923754e-01	0.716
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.895698e-01	0.538
Abacavir transmembrane transport	R-HSA-2161517	3.192990e-01	0.496
VLDL clearance	R-HSA-8964046	3.477858e-01	0.459
Disorders of Developmental Biology	R-HSA-9675151	2.264775e-01	0.645
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	3.750822e-01	0.426
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	3.750822e-01	0.426
TGFBR3 PTM regulation	R-HSA-9839383	3.750822e-01	0.426
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.578630e-01	0.589
DAP12 interactions	R-HSA-2172127	1.846810e-01	0.734
Effects of PIP2 hydrolysis	R-HSA-114508	2.450581e-01	0.611
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	2.564045e-01	0.591
Transcriptional Regulation by E2F6	R-HSA-8953750	3.139317e-01	0.503
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	2.745375e-01	0.561
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.506902e-01	0.455
Neuronal System	R-HSA-112316	2.734377e-01	0.563
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.154644e-01	0.501
Transcriptional Regulation by VENTX	R-HSA-8853884	1.518950e-01	0.818
Interleukin-6 signaling	R-HSA-1059683	1.649544e-01	0.783
Ion homeostasis	R-HSA-5578775	1.418714e-01	0.848
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.908113e-01	0.536
Histamine receptors	R-HSA-390650	1.923754e-01	0.716
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.564045e-01	0.591
Ovarian tumor domain proteases	R-HSA-5689896	2.908113e-01	0.536
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.169452e-01	0.664
Rab regulation of trafficking	R-HSA-9007101	2.019133e-01	0.695
Signaling by TGFB family members	R-HSA-9006936	1.457502e-01	0.836
The NLRP3 inflammasome	R-HSA-844456	2.735908e-01	0.563
Formation of the anterior neural plate	R-HSA-9823739	1.954062e-01	0.709
Deubiquitination	R-HSA-5688426	1.361154e-01	0.866
Transcriptional regulation of granulopoiesis	R-HSA-9616222	3.506902e-01	0.455
Vesicle-mediated transport	R-HSA-5653656	1.473810e-01	0.832
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.923754e-01	0.716
Activation of RAC1	R-HSA-428540	1.354790e-01	0.868
CLEC7A/inflammasome pathway	R-HSA-5660668	2.895698e-01	0.538
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	1.649544e-01	0.783
CREB phosphorylation	R-HSA-199920	3.192990e-01	0.496
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.192990e-01	0.496
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	2.108846e-01	0.676
Differentiation of T cells	R-HSA-9945266	2.108846e-01	0.676
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.477858e-01	0.459
Signaling by FGFR2 in disease	R-HSA-5655253	2.375409e-01	0.624
Cyclin E associated events during G1/S transition	R-HSA-69202	2.430634e-01	0.614
Cellular response to starvation	R-HSA-9711097	3.403598e-01	0.468
Cardiac conduction	R-HSA-5576891	1.821544e-01	0.740
Developmental Biology	R-HSA-1266738	1.370435e-01	0.863
Antigen processing-Cross presentation	R-HSA-1236975	2.561215e-01	0.592
Nuclear signaling by ERBB4	R-HSA-1251985	3.255117e-01	0.487
Response of endothelial cells to shear stress	R-HSA-9860931	3.687872e-01	0.433
p75NTR signals via NF-kB	R-HSA-193639	1.954062e-01	0.709
Extra-nuclear estrogen signaling	R-HSA-9009391	2.065376e-01	0.685
RUNX2 regulates bone development	R-HSA-8941326	2.792938e-01	0.554
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.418714e-01	0.848
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.706937e-01	0.568
SLC-mediated transport of neurotransmitters	R-HSA-442660	3.486578e-01	0.458
Interleukin-1 signaling	R-HSA-9020702	3.462754e-01	0.461
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.585442e-01	0.587
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.354790e-01	0.868
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	2.895698e-01	0.538
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	2.895698e-01	0.538
Synthesis of PG	R-HSA-1483148	2.264775e-01	0.645
Protein hydroxylation	R-HSA-9629569	2.893031e-01	0.539
Transcriptional regulation by small RNAs	R-HSA-5578749	1.312387e-01	0.882
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.360963e-01	0.474
Regulation of IFNA/IFNB signaling	R-HSA-912694	3.360963e-01	0.474
S Phase	R-HSA-69242	2.824015e-01	0.549
Signaling by Interleukins	R-HSA-449147	2.797265e-01	0.553
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.687058e-01	0.773
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.687058e-01	0.773
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.687058e-01	0.773
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.687058e-01	0.773
Nuclear events mediated by NFE2L2	R-HSA-9759194	2.240413e-01	0.650
Signal transduction by L1	R-HSA-445144	2.893031e-01	0.539
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.687058e-01	0.773
Interleukin-6 family signaling	R-HSA-6783589	3.667906e-01	0.436
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	2.895698e-01	0.538
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.687584e-01	0.773
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.284804e-01	0.641
PI3K Cascade	R-HSA-109704	2.375409e-01	0.624
COPI-mediated anterograde transport	R-HSA-6807878	1.776013e-01	0.751
Vitamin D (calciferol) metabolism	R-HSA-196791	2.578630e-01	0.589
STING mediated induction of host immune responses	R-HSA-1834941	2.735908e-01	0.563
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.588969e-01	0.587
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.238982e-01	0.490
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.238982e-01	0.490
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.238982e-01	0.490
ER to Golgi Anterograde Transport	R-HSA-199977	2.767550e-01	0.558
Oxidative Stress Induced Senescence	R-HSA-2559580	3.537683e-01	0.451
Signaling by Hedgehog	R-HSA-5358351	3.449427e-01	0.462
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.995248e-01	0.524
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	2.585442e-01	0.587
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.354790e-01	0.868
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	2.895698e-01	0.538
Maturation of nucleoprotein	R-HSA-9694631	2.735908e-01	0.563
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.073611e-01	0.683
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.667906e-01	0.436
Neurodegenerative Diseases	R-HSA-8863678	3.667906e-01	0.436
Signaling by SCF-KIT	R-HSA-1433557	1.762743e-01	0.754
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	3.477858e-01	0.459
Synaptic adhesion-like molecules	R-HSA-8849932	2.578630e-01	0.589
Downstream signal transduction	R-HSA-186763	2.115737e-01	0.675
Zygotic genome activation (ZGA)	R-HSA-9819196	3.049738e-01	0.516
PI Metabolism	R-HSA-1483255	2.125297e-01	0.673
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	3.515063e-01	0.454
Programmed Cell Death	R-HSA-5357801	2.591168e-01	0.587
Growth hormone receptor signaling	R-HSA-982772	1.289310e-01	0.890
SARS-CoV-1-host interactions	R-HSA-9692914	2.433951e-01	0.614
Signaling by NOTCH1	R-HSA-1980143	2.912336e-01	0.536
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.649544e-01	0.783
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.750822e-01	0.426
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	3.205788e-01	0.494
Apoptosis	R-HSA-109581	2.449156e-01	0.611
Replication of the SARS-CoV-1 genome	R-HSA-9682706	1.649544e-01	0.783
Replication of the SARS-CoV-2 genome	R-HSA-9694686	2.421482e-01	0.616
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.578630e-01	0.589
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.205788e-01	0.494
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	1.800819e-01	0.745
Gene Silencing by RNA	R-HSA-211000	1.415523e-01	0.849
Glucose metabolism	R-HSA-70326	2.019133e-01	0.695
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	2.735908e-01	0.563
SARS-CoV Infections	R-HSA-9679506	2.087764e-01	0.680
SARS-CoV-1 Infection	R-HSA-9678108	3.192183e-01	0.496
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	3.667906e-01	0.436
Selenoamino acid metabolism	R-HSA-2408522	3.760311e-01	0.425
Late Phase of HIV Life Cycle	R-HSA-162599	3.767412e-01	0.424
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.794512e-01	0.421
PI-3K cascade:FGFR2	R-HSA-5654695	3.819328e-01	0.418
Polymerase switching on the C-strand of the telomere	R-HSA-174411	3.819328e-01	0.418
Tight junction interactions	R-HSA-420029	3.819328e-01	0.418
Acyl chain remodelling of PS	R-HSA-1482801	3.819328e-01	0.418
VEGFR2 mediated cell proliferation	R-HSA-5218921	3.819328e-01	0.418
Interleukin-7 signaling	R-HSA-1266695	3.819328e-01	0.418
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	3.826964e-01	0.417
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.838308e-01	0.416
Signaling by VEGF	R-HSA-194138	3.907107e-01	0.408
SLC transporter disorders	R-HSA-5619102	3.939922e-01	0.405
Nucleosome assembly	R-HSA-774815	3.946214e-01	0.404
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	3.946214e-01	0.404
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	3.969181e-01	0.401
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	3.969181e-01	0.401
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	3.969181e-01	0.401
TRP channels	R-HSA-3295583	3.969181e-01	0.401
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.969181e-01	0.401
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.969181e-01	0.401
ALK mutants bind TKIs	R-HSA-9700645	4.012377e-01	0.397
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	4.012377e-01	0.397
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.012377e-01	0.397
Inactivation of CDC42 and RAC1	R-HSA-428543	4.012377e-01	0.397
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	4.012377e-01	0.397
Interleukin-21 signaling	R-HSA-9020958	4.012377e-01	0.397
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.012377e-01	0.397
Regulation of signaling by NODAL	R-HSA-1433617	4.012377e-01	0.397
WNT mediated activation of DVL	R-HSA-201688	4.012377e-01	0.397
Regulation of CDH11 gene transcription	R-HSA-9762293	4.012377e-01	0.397
Interleukin-1 processing	R-HSA-448706	4.012377e-01	0.397
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.012377e-01	0.397
Lipophagy	R-HSA-9613354	4.012377e-01	0.397
Regulated proteolysis of p75NTR	R-HSA-193692	4.012377e-01	0.397
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.012377e-01	0.397
G2/M Checkpoints	R-HSA-69481	4.044953e-01	0.393
Regulation of TNFR1 signaling	R-HSA-5357905	4.059923e-01	0.391
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	4.059923e-01	0.391
Signaling by TGFBR3	R-HSA-9839373	4.059923e-01	0.391
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.063936e-01	0.391
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	4.063936e-01	0.391
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.080777e-01	0.389
Regulated Necrosis	R-HSA-5218859	4.080777e-01	0.389
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.117331e-01	0.385
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	4.117331e-01	0.385
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	4.117331e-01	0.385
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.117331e-01	0.385
Interaction between L1 and Ankyrins	R-HSA-445095	4.117331e-01	0.385
MyD88 dependent cascade initiated on endosome	R-HSA-975155	4.139030e-01	0.383
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.151129e-01	0.382
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.172992e-01	0.380
tRNA processing	R-HSA-72306	4.179832e-01	0.379
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	4.214022e-01	0.375
MyD88-independent TLR4 cascade	R-HSA-166166	4.214022e-01	0.375
Negative regulation of the PI3K/AKT network	R-HSA-199418	4.251458e-01	0.371
MET activates RAP1 and RAC1	R-HSA-8875555	4.263001e-01	0.370
MAPK3 (ERK1) activation	R-HSA-110056	4.263001e-01	0.370
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.263001e-01	0.370
Receptor Mediated Mitophagy	R-HSA-8934903	4.263001e-01	0.370
Interleukin-27 signaling	R-HSA-9020956	4.263001e-01	0.370
Telomere Extension By Telomerase	R-HSA-171319	4.263658e-01	0.370
HIV elongation arrest and recovery	R-HSA-167287	4.263658e-01	0.370
Pausing and recovery of HIV elongation	R-HSA-167290	4.263658e-01	0.370
Formation of the Early Elongation Complex	R-HSA-113418	4.263658e-01	0.370
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.263658e-01	0.370
Phase 0 - rapid depolarisation	R-HSA-5576892	4.263658e-01	0.370
Activation of kainate receptors upon glutamate binding	R-HSA-451326	4.263658e-01	0.370
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.263658e-01	0.370
Inflammasomes	R-HSA-622312	4.263658e-01	0.370
Pyroptosis	R-HSA-5620971	4.263658e-01	0.370
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	4.270184e-01	0.370
Regulation of CDH1 Gene Transcription	R-HSA-9764560	4.270184e-01	0.370
Generic Transcription Pathway	R-HSA-212436	4.274634e-01	0.369
Ub-specific processing proteases	R-HSA-5689880	4.359600e-01	0.361
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.438141e-01	0.353
Circadian clock	R-HSA-9909396	4.457164e-01	0.351
Presynaptic depolarization and calcium channel opening	R-HSA-112308	4.503148e-01	0.346
vRNP Assembly	R-HSA-192905	4.503148e-01	0.346
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.503148e-01	0.346
Cellular responses to mechanical stimuli	R-HSA-9855142	4.512479e-01	0.346
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.550429e-01	0.342
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.550429e-01	0.342
Ca2+ pathway	R-HSA-4086398	4.551203e-01	0.342
PPARA activates gene expression	R-HSA-1989781	4.597133e-01	0.338
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	4.655621e-01	0.332
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	4.660465e-01	0.332
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	4.690695e-01	0.329
HIV Life Cycle	R-HSA-162587	4.723522e-01	0.326
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	4.723522e-01	0.326
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.726348e-01	0.325
Uptake and actions of bacterial toxins	R-HSA-5339562	4.726348e-01	0.325
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.733258e-01	0.325
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.733258e-01	0.325
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.733258e-01	0.325
NF-kB is activated and signals survival	R-HSA-209560	4.733258e-01	0.325
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.733258e-01	0.325
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.733258e-01	0.325
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	4.733258e-01	0.325
Reduction of cytosolic Ca++ levels	R-HSA-418359	4.733258e-01	0.325
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	4.735992e-01	0.325
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	4.736929e-01	0.325
Integration of energy metabolism	R-HSA-163685	4.796842e-01	0.319
Hemostasis	R-HSA-109582	4.820828e-01	0.317
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.828781e-01	0.316
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.834198e-01	0.316
Telomere Maintenance	R-HSA-157579	4.898311e-01	0.310
Signaling by WNT	R-HSA-195721	4.917966e-01	0.308
Homology Directed Repair	R-HSA-5693538	4.953059e-01	0.305
Scavenging by Class F Receptors	R-HSA-3000484	4.953747e-01	0.305
Leading Strand Synthesis	R-HSA-69109	4.953747e-01	0.305
Polymerase switching	R-HSA-69091	4.953747e-01	0.305
Serotonin clearance from the synaptic cleft	R-HSA-380615	4.953747e-01	0.305
Regulation of IFNG signaling	R-HSA-877312	4.953747e-01	0.305
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.953747e-01	0.305
Interleukin-35 Signalling	R-HSA-8984722	4.953747e-01	0.305
Interleukin-15 signaling	R-HSA-8983432	4.953747e-01	0.305
Trafficking and processing of endosomal TLR	R-HSA-1679131	4.953747e-01	0.305
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.953747e-01	0.305
Role of second messengers in netrin-1 signaling	R-HSA-418890	4.953747e-01	0.305
Disorders of Nervous System Development	R-HSA-9697154	4.953747e-01	0.305
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	4.953747e-01	0.305
Pervasive developmental disorders	R-HSA-9005895	4.953747e-01	0.305
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	4.953747e-01	0.305
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	4.953747e-01	0.305
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.953747e-01	0.305
p75NTR recruits signalling complexes	R-HSA-209543	4.953747e-01	0.305
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	4.964622e-01	0.304
FGFR1 mutant receptor activation	R-HSA-1839124	4.964622e-01	0.304
Integrin signaling	R-HSA-354192	4.964622e-01	0.304
Regulation of necroptotic cell death	R-HSA-5675482	4.964622e-01	0.304
Transcriptional regulation by RUNX2	R-HSA-8878166	5.025383e-01	0.299
Signaling by NOTCH3	R-HSA-9012852	5.046662e-01	0.297
HATs acetylate histones	R-HSA-3214847	5.057877e-01	0.296
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	5.098082e-01	0.293
Sensory processing of sound	R-HSA-9659379	5.098082e-01	0.293
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.098166e-01	0.293
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	5.098166e-01	0.293
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	5.098166e-01	0.293
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.151187e-01	0.288
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	5.151187e-01	0.288
TNF signaling	R-HSA-75893	5.151187e-01	0.288
Adenylate cyclase activating pathway	R-HSA-170660	5.165019e-01	0.287
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	5.165019e-01	0.287
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.165019e-01	0.287
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.165019e-01	0.287
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	5.165019e-01	0.287
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.165019e-01	0.287
Diseases of nucleotide metabolism	R-HSA-9735804	5.165019e-01	0.287
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.165019e-01	0.287
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.165019e-01	0.287
Reversible hydration of carbon dioxide	R-HSA-1475029	5.165019e-01	0.287
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.165019e-01	0.287
CD28 dependent Vav1 pathway	R-HSA-389359	5.165019e-01	0.287
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	5.165019e-01	0.287
Maturation of nucleoprotein	R-HSA-9683610	5.165019e-01	0.287
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	5.186850e-01	0.285
Dual Incision in GG-NER	R-HSA-5696400	5.229367e-01	0.282
Regulation of TLR by endogenous ligand	R-HSA-5686938	5.229367e-01	0.282
Viral Infection Pathways	R-HSA-9824446	5.239611e-01	0.281
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.274856e-01	0.278
Processing of DNA double-strand break ends	R-HSA-5693607	5.274856e-01	0.278
Maternal to zygotic transition (MZT)	R-HSA-9816359	5.310811e-01	0.275
Dual incision in TC-NER	R-HSA-6782135	5.356630e-01	0.271
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.356630e-01	0.271
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.358186e-01	0.271
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.367458e-01	0.270
cGMP effects	R-HSA-418457	5.367458e-01	0.270
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.367458e-01	0.270
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	5.367458e-01	0.270
P2Y receptors	R-HSA-417957	5.367458e-01	0.270
Host Interactions of HIV factors	R-HSA-162909	5.381114e-01	0.269
Toll-like Receptor Cascades	R-HSA-168898	5.415284e-01	0.266
Extension of Telomeres	R-HSA-180786	5.457479e-01	0.263
G1/S-Specific Transcription	R-HSA-69205	5.484594e-01	0.261
FLT3 signaling in disease	R-HSA-9682385	5.484594e-01	0.261
G1/S Transition	R-HSA-69206	5.520341e-01	0.258
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.534042e-01	0.257
GABA receptor activation	R-HSA-977443	5.557039e-01	0.255
Adenylate cyclase inhibitory pathway	R-HSA-170670	5.561433e-01	0.255
G beta:gamma signalling through BTK	R-HSA-8964315	5.561433e-01	0.255
Translesion synthesis by REV1	R-HSA-110312	5.561433e-01	0.255
Telomere C-strand synthesis initiation	R-HSA-174430	5.561433e-01	0.255
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.561433e-01	0.255
Transport and metabolism of PAPS	R-HSA-174362	5.561433e-01	0.255
Signaling by Activin	R-HSA-1502540	5.561433e-01	0.255
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.561433e-01	0.255
Lysosphingolipid and LPA receptors	R-HSA-419408	5.561433e-01	0.255
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.561433e-01	0.255
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.561433e-01	0.255
DNA Repair	R-HSA-73894	5.578790e-01	0.253
Nucleotide Excision Repair	R-HSA-5696398	5.599391e-01	0.252
Degradation of DVL	R-HSA-4641258	5.608566e-01	0.251
Beta-oxidation of very long chain fatty acids	R-HSA-390247	5.608566e-01	0.251
SLC-mediated transport of organic cations	R-HSA-549127	5.608566e-01	0.251
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.608566e-01	0.251
MAPK6/MAPK4 signaling	R-HSA-5687128	5.618746e-01	0.250
MAP kinase activation	R-HSA-450294	5.655283e-01	0.248
MET promotes cell motility	R-HSA-8875878	5.730085e-01	0.242
RIPK1-mediated regulated necrosis	R-HSA-5213460	5.730085e-01	0.242
Cellular response to chemical stress	R-HSA-9711123	5.740921e-01	0.241
Translesion synthesis by POLI	R-HSA-5656121	5.747297e-01	0.241
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.747297e-01	0.241
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	5.747297e-01	0.241
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	5.747297e-01	0.241
Phosphorylation of the APC/C	R-HSA-176412	5.747297e-01	0.241
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	5.747297e-01	0.241
Fructose catabolism	R-HSA-70350	5.747297e-01	0.241
Regulation of NF-kappa B signaling	R-HSA-9758274	5.747297e-01	0.241
Atorvastatin ADME	R-HSA-9754706	5.747297e-01	0.241
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	5.752187e-01	0.240
Heme signaling	R-HSA-9707616	5.752187e-01	0.240
Signaling by PDGF	R-HSA-186797	5.752187e-01	0.240
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	5.849139e-01	0.233
Stabilization of p53	R-HSA-69541	5.849139e-01	0.233
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	5.849139e-01	0.233
Translesion synthesis by POLK	R-HSA-5655862	5.925388e-01	0.227
Acetylcholine regulates insulin secretion	R-HSA-399997	5.925388e-01	0.227
Scavenging by Class B Receptors	R-HSA-3000471	5.925388e-01	0.227
Transcriptional regulation of testis differentiation	R-HSA-9690406	5.925388e-01	0.227
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.925388e-01	0.227
Passive transport by Aquaporins	R-HSA-432047	5.925388e-01	0.227
tRNA modification in the mitochondrion	R-HSA-6787450	5.925388e-01	0.227
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.941891e-01	0.226
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	5.965720e-01	0.224
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	5.965720e-01	0.224
HIV Transcription Elongation	R-HSA-167169	5.965720e-01	0.224
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	5.965720e-01	0.224
Transcriptional Regulation by TP53	R-HSA-3700989	5.983517e-01	0.223
Transport to the Golgi and subsequent modification	R-HSA-948021	6.022674e-01	0.220
Platelet activation, signaling and aggregation	R-HSA-76002	6.024139e-01	0.220
ER-Phagosome pathway	R-HSA-1236974	6.028671e-01	0.220
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.079828e-01	0.216
FLT3 Signaling	R-HSA-9607240	6.079828e-01	0.216
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.096032e-01	0.215
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	6.096032e-01	0.215
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.096032e-01	0.215
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.096032e-01	0.215
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	6.096032e-01	0.215
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.096032e-01	0.215
Uptake and function of anthrax toxins	R-HSA-5210891	6.096032e-01	0.215
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.121370e-01	0.213
Adaptive Immune System	R-HSA-1280218	6.178544e-01	0.209
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.191466e-01	0.208
Intra-Golgi traffic	R-HSA-6811438	6.191466e-01	0.208
HCMV Late Events	R-HSA-9610379	6.197845e-01	0.208
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	6.248918e-01	0.204
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	6.259540e-01	0.203
Mismatch Repair	R-HSA-5358508	6.259540e-01	0.203
PKA activation in glucagon signalling	R-HSA-164378	6.259540e-01	0.203
PKA activation	R-HSA-163615	6.259540e-01	0.203
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.259540e-01	0.203
Nucleotide-like (purinergic) receptors	R-HSA-418038	6.259540e-01	0.203
Activation of GABAB receptors	R-HSA-991365	6.300639e-01	0.201
GABA B receptor activation	R-HSA-977444	6.300639e-01	0.201
RNA Polymerase I Transcription Initiation	R-HSA-73762	6.300639e-01	0.201
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.300639e-01	0.201
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	6.300639e-01	0.201
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	6.391487e-01	0.194
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	6.407358e-01	0.193
Response of Mtb to phagocytosis	R-HSA-9637690	6.407358e-01	0.193
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.416209e-01	0.193
Translesion Synthesis by POLH	R-HSA-110320	6.416209e-01	0.193
E2F mediated regulation of DNA replication	R-HSA-113510	6.416209e-01	0.193
Pre-NOTCH Processing in Golgi	R-HSA-1912420	6.416209e-01	0.193
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	6.416209e-01	0.193
Other interleukin signaling	R-HSA-449836	6.416209e-01	0.193
Interferon alpha/beta signaling	R-HSA-909733	6.452187e-01	0.190
Interleukin-17 signaling	R-HSA-448424	6.477093e-01	0.189
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.477093e-01	0.189
G1 Phase	R-HSA-69236	6.511637e-01	0.186
Cyclin D associated events in G1	R-HSA-69231	6.511637e-01	0.186
EPHB-mediated forward signaling	R-HSA-3928662	6.511637e-01	0.186
Amine ligand-binding receptors	R-HSA-375280	6.511637e-01	0.186
Signaling by NODAL	R-HSA-1181150	6.566325e-01	0.183
Negative regulation of MET activity	R-HSA-6807004	6.566325e-01	0.183
Nephrin family interactions	R-HSA-373753	6.566325e-01	0.183
Mitochondrial biogenesis	R-HSA-1592230	6.583801e-01	0.182
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	6.613494e-01	0.180
Platelet Aggregation (Plug Formation)	R-HSA-76009	6.613494e-01	0.180
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	6.613494e-01	0.180
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	6.613494e-01	0.180
Ion channel transport	R-HSA-983712	6.641522e-01	0.178
G-protein activation	R-HSA-202040	6.710162e-01	0.173
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	6.710162e-01	0.173
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.710162e-01	0.173
Lagging Strand Synthesis	R-HSA-69186	6.710162e-01	0.173
PKA-mediated phosphorylation of CREB	R-HSA-111931	6.710162e-01	0.173
ERK/MAPK targets	R-HSA-198753	6.710162e-01	0.173
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	6.710162e-01	0.173
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	6.712949e-01	0.173
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	6.712949e-01	0.173
Signaling by NOTCH	R-HSA-157118	6.729734e-01	0.172
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.847982e-01	0.164
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	6.847982e-01	0.164
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	6.847982e-01	0.164
Listeria monocytogenes entry into host cells	R-HSA-8876384	6.847982e-01	0.164
Serine metabolism	R-HSA-977347	6.847982e-01	0.164
Glutathione synthesis and recycling	R-HSA-174403	6.847982e-01	0.164
Ribavirin ADME	R-HSA-9755088	6.847982e-01	0.164
Protein ubiquitination	R-HSA-8852135	6.883325e-01	0.162
Non-integrin membrane-ECM interactions	R-HSA-3000171	6.883325e-01	0.162
Co-stimulation by CD28	R-HSA-389356	6.904741e-01	0.161
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	6.904741e-01	0.161
PIP3 activates AKT signaling	R-HSA-1257604	6.939344e-01	0.159
Phospholipid metabolism	R-HSA-1483257	6.939344e-01	0.159
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.960216e-01	0.157
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.980036e-01	0.156
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.980036e-01	0.156
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.980036e-01	0.156
RAF-independent MAPK1/3 activation	R-HSA-112409	6.980036e-01	0.156
Fructose metabolism	R-HSA-5652084	6.980036e-01	0.156
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	6.980036e-01	0.156
LDL clearance	R-HSA-8964038	6.980036e-01	0.156
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.997131e-01	0.155
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.997131e-01	0.155
Mitotic G1 phase and G1/S transition	R-HSA-453279	7.014808e-01	0.154
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	7.035663e-01	0.153
Regulation of PD-L1(CD274) expression	R-HSA-9909648	7.073405e-01	0.150
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.106565e-01	0.148
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.106565e-01	0.148
Interleukin-20 family signaling	R-HSA-8854691	7.106565e-01	0.148
Syndecan interactions	R-HSA-3000170	7.106565e-01	0.148
Carnitine shuttle	R-HSA-200425	7.106565e-01	0.148
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	7.106565e-01	0.148
RNA Polymerase I Transcription	R-HSA-73864	7.109673e-01	0.148
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	7.123397e-01	0.147
Regulation of CDH1 Expression and Function	R-HSA-9764265	7.123397e-01	0.147
Activation of NF-kappaB in B cells	R-HSA-1169091	7.175043e-01	0.144
Cell-cell junction organization	R-HSA-421270	7.209585e-01	0.142
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	7.227801e-01	0.141
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.227801e-01	0.141
Thromboxane signalling through TP receptor	R-HSA-428930	7.227801e-01	0.141
TNFs bind their physiological receptors	R-HSA-5669034	7.227801e-01	0.141
Potential therapeutics for SARS	R-HSA-9679191	7.228043e-01	0.141
MITF-M-dependent gene expression	R-HSA-9856651	7.228043e-01	0.141
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	7.235981e-01	0.141
Platelet degranulation	R-HSA-114608	7.250020e-01	0.140
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.260627e-01	0.139
RNA Polymerase I Promoter Escape	R-HSA-73772	7.260627e-01	0.139
Neurexins and neuroligins	R-HSA-6794361	7.260627e-01	0.139
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	7.260627e-01	0.139
Cell junction organization	R-HSA-446728	7.269263e-01	0.139
Interleukin-1 family signaling	R-HSA-446652	7.330601e-01	0.135
G protein gated Potassium channels	R-HSA-1296059	7.343964e-01	0.134
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.343964e-01	0.134
Activation of G protein gated Potassium channels	R-HSA-1296041	7.343964e-01	0.134
Laminin interactions	R-HSA-3000157	7.343964e-01	0.134
TGFBR3 expression	R-HSA-9839394	7.343964e-01	0.134
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.343964e-01	0.134
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.343964e-01	0.134
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.344006e-01	0.134
Meiotic synapsis	R-HSA-1221632	7.344006e-01	0.134
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	7.391504e-01	0.131
Post-translational protein modification	R-HSA-597592	7.417891e-01	0.130
Platelet homeostasis	R-HSA-418346	7.417936e-01	0.130
Class I MHC mediated antigen processing & presentation	R-HSA-983169	7.427047e-01	0.129
Metalloprotease DUBs	R-HSA-5689901	7.455266e-01	0.128
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.455266e-01	0.128
MET activates PTK2 signaling	R-HSA-8874081	7.455266e-01	0.128
Attachment of bacteria to epithelial cells	R-HSA-9638630	7.455266e-01	0.128
Abacavir ADME	R-HSA-2161522	7.455266e-01	0.128
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	7.455266e-01	0.128
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.455266e-01	0.128
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.455266e-01	0.128
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.504291e-01	0.125
HDACs deacetylate histones	R-HSA-3214815	7.504291e-01	0.125
Stimuli-sensing channels	R-HSA-2672351	7.534101e-01	0.123
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.561910e-01	0.121
Packaging Of Telomere Ends	R-HSA-171306	7.561910e-01	0.121
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	7.561910e-01	0.121
RNA Polymerase I Transcription Termination	R-HSA-73863	7.561910e-01	0.121
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	7.561910e-01	0.121
Triglyceride biosynthesis	R-HSA-75109	7.561910e-01	0.121
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.561910e-01	0.121
Insulin processing	R-HSA-264876	7.561910e-01	0.121
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.581268e-01	0.120
Detoxification of Reactive Oxygen Species	R-HSA-3299685	7.581268e-01	0.120
Protein-protein interactions at synapses	R-HSA-6794362	7.588245e-01	0.120
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	7.622033e-01	0.118
TCR signaling	R-HSA-202403	7.646205e-01	0.117
Synthesis of PA	R-HSA-1483166	7.656183e-01	0.116
Prednisone ADME	R-HSA-9757110	7.664092e-01	0.116
Negative regulation of FGFR3 signaling	R-HSA-5654732	7.664092e-01	0.116
Pyrimidine salvage	R-HSA-73614	7.664092e-01	0.116
Cell-Cell communication	R-HSA-1500931	7.715651e-01	0.113
Intracellular signaling by second messengers	R-HSA-9006925	7.721785e-01	0.112
Early SARS-CoV-2 Infection Events	R-HSA-9772572	7.729075e-01	0.112
Late endosomal microautophagy	R-HSA-9615710	7.761997e-01	0.110
Termination of translesion DNA synthesis	R-HSA-5656169	7.761997e-01	0.110
mRNA Capping	R-HSA-72086	7.761997e-01	0.110
Thyroxine biosynthesis	R-HSA-209968	7.761997e-01	0.110
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	7.761997e-01	0.110
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	7.761997e-01	0.110
Activation of Matrix Metalloproteinases	R-HSA-1592389	7.761997e-01	0.110
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.761997e-01	0.110
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	7.761997e-01	0.110
Regulation of CDH11 Expression and Function	R-HSA-9759475	7.761997e-01	0.110
Peroxisomal protein import	R-HSA-9033241	7.799981e-01	0.108
Diseases of programmed cell death	R-HSA-9645723	7.831712e-01	0.106
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	7.855804e-01	0.105
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.855804e-01	0.105
Activation of BH3-only proteins	R-HSA-114452	7.855804e-01	0.105
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.855804e-01	0.105
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	7.855804e-01	0.105
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	7.855804e-01	0.105
Neurotransmitter clearance	R-HSA-112311	7.855804e-01	0.105
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	7.855804e-01	0.105
Activation of the pre-replicative complex	R-HSA-68962	7.855804e-01	0.105
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	7.864410e-01	0.104
Aquaporin-mediated transport	R-HSA-445717	7.935988e-01	0.100
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.935988e-01	0.100
Nucleotide salvage	R-HSA-8956321	7.935988e-01	0.100
PLC beta mediated events	R-HSA-112043	7.935988e-01	0.100
Collagen degradation	R-HSA-1442490	7.935988e-01	0.100
Downstream TCR signaling	R-HSA-202424	7.945635e-01	0.100
Neurotransmitter release cycle	R-HSA-112310	7.945635e-01	0.100
Base Excision Repair	R-HSA-73884	7.945635e-01	0.100
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.945684e-01	0.100
Trafficking of AMPA receptors	R-HSA-399719	7.945684e-01	0.100
Molecules associated with elastic fibres	R-HSA-2129379	7.945684e-01	0.100
Evasion by RSV of host interferon responses	R-HSA-9833109	7.945684e-01	0.100
Adherens junctions interactions	R-HSA-418990	7.965955e-01	0.099
NCAM signaling for neurite out-growth	R-HSA-375165	8.001166e-01	0.097
Inwardly rectifying K+ channels	R-HSA-1296065	8.031803e-01	0.095
DNA strand elongation	R-HSA-69190	8.031803e-01	0.095
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.031803e-01	0.095
Disorders of transmembrane transporters	R-HSA-5619115	8.044542e-01	0.094
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	8.114316e-01	0.091
G-protein beta:gamma signalling	R-HSA-397795	8.114316e-01	0.091
Negative regulation of FGFR1 signaling	R-HSA-5654726	8.114316e-01	0.091
Activation of ATR in response to replication stress	R-HSA-176187	8.114316e-01	0.091
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.114316e-01	0.091
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	8.114316e-01	0.091
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	8.114578e-01	0.091
Cellular response to hypoxia	R-HSA-1234174	8.185870e-01	0.087
Glucagon signaling in metabolic regulation	R-HSA-163359	8.193375e-01	0.087
DNA Damage Recognition in GG-NER	R-HSA-5696394	8.193375e-01	0.087
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.193375e-01	0.087
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.193375e-01	0.087
tRNA modification in the nucleus and cytosol	R-HSA-6782315	8.243956e-01	0.084
Co-inhibition by PD-1	R-HSA-389948	8.256607e-01	0.083
NOD1/2 Signaling Pathway	R-HSA-168638	8.269123e-01	0.083
eNOS activation	R-HSA-203615	8.269123e-01	0.083
Signal amplification	R-HSA-392518	8.269123e-01	0.083
Negative regulation of FGFR2 signaling	R-HSA-5654727	8.269123e-01	0.083
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	8.269123e-01	0.083
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	8.269123e-01	0.083
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	8.269123e-01	0.083
Mitophagy	R-HSA-5205647	8.269123e-01	0.083
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	8.269123e-01	0.083
Signaling by NOTCH2	R-HSA-1980145	8.269123e-01	0.083
HIV Infection	R-HSA-162906	8.276034e-01	0.082
G-protein mediated events	R-HSA-112040	8.300366e-01	0.081
GPCR downstream signalling	R-HSA-388396	8.316911e-01	0.080
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.318953e-01	0.080
Regulation of T cell activation by CD28 family	R-HSA-388841	8.331665e-01	0.079
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	8.341701e-01	0.079
PERK regulates gene expression	R-HSA-381042	8.341701e-01	0.079
Transcription of the HIV genome	R-HSA-167172	8.355139e-01	0.078
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.357521e-01	0.078
PRC2 methylates histones and DNA	R-HSA-212300	8.411239e-01	0.075
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.411239e-01	0.075
RNA Polymerase III Transcription	R-HSA-74158	8.411239e-01	0.075
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.411239e-01	0.075
GPVI-mediated activation cascade	R-HSA-114604	8.411239e-01	0.075
Calmodulin induced events	R-HSA-111933	8.411239e-01	0.075
CaM pathway	R-HSA-111997	8.411239e-01	0.075
Post-translational protein phosphorylation	R-HSA-8957275	8.442561e-01	0.074
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.459921e-01	0.073
COPII-mediated vesicle transport	R-HSA-204005	8.459921e-01	0.073
Degradation of AXIN	R-HSA-4641257	8.477865e-01	0.072
Cleavage of the damaged purine	R-HSA-110331	8.477865e-01	0.072
Metabolism of folate and pterines	R-HSA-196757	8.477865e-01	0.072
FOXO-mediated transcription	R-HSA-9614085	8.486023e-01	0.071
Hedgehog 'on' state	R-HSA-5632684	8.510007e-01	0.070
ECM proteoglycans	R-HSA-3000178	8.510007e-01	0.070
Developmental Cell Lineages	R-HSA-9734767	8.531538e-01	0.069
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.541701e-01	0.068
Depurination	R-HSA-73927	8.541701e-01	0.068
Purine salvage	R-HSA-74217	8.541701e-01	0.068
Elastic fibre formation	R-HSA-1566948	8.541701e-01	0.068
Biofilm formation	R-HSA-9931953	8.541701e-01	0.068
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	8.541701e-01	0.068
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	8.558605e-01	0.068
Pentose phosphate pathway	R-HSA-71336	8.602864e-01	0.065
Plasma lipoprotein clearance	R-HSA-8964043	8.602864e-01	0.065
Regulation of endogenous retroelements	R-HSA-9842860	8.610135e-01	0.065
ROS and RNS production in phagocytes	R-HSA-1222556	8.651484e-01	0.063
Formation of Incision Complex in GG-NER	R-HSA-5696395	8.661465e-01	0.062
Generation of second messenger molecules	R-HSA-202433	8.661465e-01	0.062
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	8.717611e-01	0.060
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.717611e-01	0.060
Scavenging by Class A Receptors	R-HSA-3000480	8.771406e-01	0.057
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.771406e-01	0.057
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.771406e-01	0.057
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.771406e-01	0.057
Translation of Structural Proteins	R-HSA-9683701	8.771406e-01	0.057
Translation of Structural Proteins	R-HSA-9694635	8.780545e-01	0.056
Cholesterol biosynthesis	R-HSA-191273	8.820969e-01	0.054
Interleukin-10 signaling	R-HSA-6783783	8.820969e-01	0.054
Cleavage of the damaged pyrimidine	R-HSA-110329	8.822947e-01	0.054
Depyrimidination	R-HSA-73928	8.822947e-01	0.054
Ca-dependent events	R-HSA-111996	8.822947e-01	0.054
Signaling by GPCR	R-HSA-372790	8.828063e-01	0.054
Beta-catenin independent WNT signaling	R-HSA-3858494	8.918014e-01	0.050
Methylation	R-HSA-156581	8.919642e-01	0.050
Surfactant metabolism	R-HSA-5683826	8.919642e-01	0.050
Netrin-1 signaling	R-HSA-373752	8.919642e-01	0.050
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	8.964973e-01	0.047
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.964973e-01	0.047
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	8.964973e-01	0.047
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	8.964973e-01	0.047
DAG and IP3 signaling	R-HSA-1489509	8.964973e-01	0.047
FCERI mediated MAPK activation	R-HSA-2871796	8.991908e-01	0.046
PTEN Regulation	R-HSA-6807070	9.001360e-01	0.046
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.008404e-01	0.045
Regulation of pyruvate metabolism	R-HSA-9861718	9.008404e-01	0.045
Diseases of DNA repair	R-HSA-9675135	9.008404e-01	0.045
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.021453e-01	0.045
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	9.038569e-01	0.044
Peroxisomal lipid metabolism	R-HSA-390918	9.038569e-01	0.044
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.050016e-01	0.043
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.050016e-01	0.043
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.050016e-01	0.043
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.053732e-01	0.043
Meiosis	R-HSA-1500620	9.070972e-01	0.042
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.078210e-01	0.042
C-type lectin receptors (CLRs)	R-HSA-5621481	9.082264e-01	0.042
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.105456e-01	0.041
DNA Damage Bypass	R-HSA-73893	9.128080e-01	0.040
Degradation of CDH1	R-HSA-9766229	9.128080e-01	0.040
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	9.132737e-01	0.039
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.132737e-01	0.039
Azathioprine ADME	R-HSA-9748787	9.164676e-01	0.038
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.233331e-01	0.035
Gastrulation	R-HSA-9758941	9.260446e-01	0.033
Amino acids regulate mTORC1	R-HSA-9639288	9.265515e-01	0.033
Nucleotide biosynthesis	R-HSA-8956320	9.265515e-01	0.033
Pre-NOTCH Transcription and Translation	R-HSA-1912408	9.270705e-01	0.033
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.296351e-01	0.032
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.319869e-01	0.031
MITF-M-regulated melanocyte development	R-HSA-9730414	9.325775e-01	0.030
G alpha (z) signalling events	R-HSA-418597	9.325893e-01	0.030
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.343259e-01	0.030
Metabolism of amine-derived hormones	R-HSA-209776	9.354197e-01	0.029
Intrinsic Pathway for Apoptosis	R-HSA-109606	9.354197e-01	0.029
Regulation of CDH1 Function	R-HSA-9764561	9.381314e-01	0.028
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.407294e-01	0.027
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.429414e-01	0.026
Triglyceride metabolism	R-HSA-8979227	9.432185e-01	0.025
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.432185e-01	0.025
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.448077e-01	0.025
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	9.456031e-01	0.024
Glutathione conjugation	R-HSA-156590	9.456031e-01	0.024
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	9.456031e-01	0.024
Signaling by Retinoic Acid	R-HSA-5362517	9.456031e-01	0.024
Regulation of insulin secretion	R-HSA-422356	9.468353e-01	0.024
Neutrophil degranulation	R-HSA-6798695	9.470840e-01	0.024
Opioid Signalling	R-HSA-111885	9.570545e-01	0.019
Activation of HOX genes during differentiation	R-HSA-5619507	9.585637e-01	0.018
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	9.585637e-01	0.018
HDR through Homologous Recombination (HRR)	R-HSA-5685942	9.597183e-01	0.018
Nicotinate metabolism	R-HSA-196807	9.597183e-01	0.018
SLC-mediated transport of amino acids	R-HSA-9958863	9.597183e-01	0.018
Glycerophospholipid biosynthesis	R-HSA-1483206	9.603205e-01	0.018
G alpha (s) signalling events	R-HSA-418555	9.616706e-01	0.017
Synthesis of DNA	R-HSA-69239	9.627923e-01	0.016
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.645859e-01	0.016
NoRC negatively regulates rRNA expression	R-HSA-427413	9.660742e-01	0.015
Metabolism of cofactors	R-HSA-8978934	9.660742e-01	0.015
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	9.660742e-01	0.015
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.675000e-01	0.014
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	9.675000e-01	0.014
Purine catabolism	R-HSA-74259	9.675000e-01	0.014
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	9.675000e-01	0.014
Switching of origins to a post-replicative state	R-HSA-69052	9.688660e-01	0.014
FCERI mediated NF-kB activation	R-HSA-2871837	9.691425e-01	0.014
Signaling by NOTCH4	R-HSA-9013694	9.701747e-01	0.013
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.714284e-01	0.013
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.740953e-01	0.011
Role of phospholipids in phagocytosis	R-HSA-2029485	9.740953e-01	0.011
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.746230e-01	0.011
Integrin cell surface interactions	R-HSA-216083	9.748826e-01	0.011
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.759387e-01	0.011
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.762349e-01	0.010
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	9.769504e-01	0.010
DNA Replication	R-HSA-69306	9.770039e-01	0.010
Amyloid fiber formation	R-HSA-977225	9.779197e-01	0.010
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.792003e-01	0.009
Cytoprotection by HMOX1	R-HSA-9707564	9.797378e-01	0.009
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.797378e-01	0.009
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.821886e-01	0.008
Pyruvate metabolism	R-HSA-70268	9.836556e-01	0.007
Interleukin-12 family signaling	R-HSA-447115	9.836556e-01	0.007
Translation	R-HSA-72766	9.847914e-01	0.007
Metabolism of nucleotides	R-HSA-15869	9.848275e-01	0.007
Reproduction	R-HSA-1474165	9.861451e-01	0.006
Degradation of the extracellular matrix	R-HSA-1474228	9.871382e-01	0.006
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.873716e-01	0.006
Immune System	R-HSA-168256	9.876014e-01	0.005
Assembly of the pre-replicative complex	R-HSA-68867	9.879031e-01	0.005
Collagen formation	R-HSA-1474290	9.884122e-01	0.005
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.898149e-01	0.004
Potassium Channels	R-HSA-1296071	9.898149e-01	0.004
Metabolism of proteins	R-HSA-392499	9.900547e-01	0.004
Leishmania phagocytosis	R-HSA-9664417	9.908130e-01	0.004
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.908130e-01	0.004
Parasite infection	R-HSA-9664407	9.908130e-01	0.004
Metabolism of steroids	R-HSA-8957322	9.912945e-01	0.004
ABC-family proteins mediated transport	R-HSA-382556	9.914249e-01	0.004
Infectious disease	R-HSA-5663205	9.914915e-01	0.004
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.917277e-01	0.004
RSV-host interactions	R-HSA-9833110	9.930848e-01	0.003
DNA Replication Pre-Initiation	R-HSA-69002	9.944238e-01	0.002
Protein localization	R-HSA-9609507	9.945854e-01	0.002
Cell surface interactions at the vascular wall	R-HSA-202733	9.952471e-01	0.002
Disease	R-HSA-1643685	9.954066e-01	0.002
Parasitic Infection Pathways	R-HSA-9824443	9.961065e-01	0.002
Leishmania infection	R-HSA-9658195	9.961065e-01	0.002
Asparagine N-linked glycosylation	R-HSA-446203	9.963120e-01	0.002
Peptide hormone metabolism	R-HSA-2980736	9.963749e-01	0.002
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.972006e-01	0.001
Formation of the cornified envelope	R-HSA-6809371	9.973187e-01	0.001
Extracellular matrix organization	R-HSA-1474244	9.974076e-01	0.001
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.975758e-01	0.001
Leishmania parasite growth and survival	R-HSA-9664433	9.975758e-01	0.001
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.976439e-01	0.001
Drug ADME	R-HSA-9748784	9.977065e-01	0.001
Nucleotide catabolism	R-HSA-8956319	9.979297e-01	0.001
Neddylation	R-HSA-8951664	9.979394e-01	0.001
Sensory perception of taste	R-HSA-9717189	9.981809e-01	0.001
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.985081e-01	0.001
Peptide ligand-binding receptors	R-HSA-375276	9.985340e-01	0.001
Bacterial Infection Pathways	R-HSA-9824439	9.987266e-01	0.001
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.988704e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.992375e-01	0.000
Interferon gamma signaling	R-HSA-877300	9.995016e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.996829e-01	0.000
Transport of small molecules	R-HSA-382551	9.997514e-01	0.000
Innate Immune System	R-HSA-168249	9.998189e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.998250e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.998381e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.998903e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.998926e-01	0.000
Infection with Enterobacteria	R-HSA-9640148	9.999289e-01	0.000
Keratinization	R-HSA-6805567	9.999402e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999418e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999779e-01	0.000
Fatty acid metabolism	R-HSA-8978868	9.999884e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999974e-01	0.000
GPCR ligand binding	R-HSA-500792	9.999980e-01	0.000
Diseases of metabolism	R-HSA-5668914	9.999992e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999998e-01	0.000
Metabolism of lipids	R-HSA-556833	9.999999e-01	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Peptide chain elongation	R-HSA-156902	1.110223e-16	15.955
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.110223e-16	15.955
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	1.110223e-16	15.955
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.110223e-16	15.955
Formation of a pool of free 40S subunits	R-HSA-72689	1.110223e-16	15.955
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.110223e-16	15.955
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.110223e-16	15.955
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.110223e-16	15.955
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.110223e-16	15.955
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.110223e-16	15.955
Eukaryotic Translation Elongation	R-HSA-156842	1.110223e-16	15.955
Eukaryotic Translation Initiation	R-HSA-72613	1.110223e-16	15.955
Cap-dependent Translation Initiation	R-HSA-72737	1.110223e-16	15.955
Eukaryotic Translation Termination	R-HSA-72764	1.110223e-16	15.955
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	1.110223e-16	15.955
Signaling by ROBO receptors	R-HSA-376176	1.110223e-16	15.955
Selenocysteine synthesis	R-HSA-2408557	4.440892e-16	15.353
Viral mRNA Translation	R-HSA-192823	6.661338e-16	15.176
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.554312e-15	14.808
Ribosome-associated quality control	R-HSA-9948299	5.995204e-15	14.222
Axon guidance	R-HSA-422475	5.662137e-15	14.247
Influenza Infection	R-HSA-168255	5.995204e-15	14.222
Nervous system development	R-HSA-9675108	1.820766e-14	13.740
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	2.065015e-14	13.685
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.203482e-13	12.920
rRNA processing in the nucleus and cytosol	R-HSA-8868773	4.787282e-13	12.320
Metabolism of RNA	R-HSA-8953854	4.130252e-12	11.384
Cellular response to starvation	R-HSA-9711097	5.261014e-12	11.279
Cellular responses to stress	R-HSA-2262752	5.353828e-12	11.271
Cellular responses to stimuli	R-HSA-8953897	1.117284e-11	10.952
Selenoamino acid metabolism	R-HSA-2408522	5.371248e-11	10.270
rRNA processing	R-HSA-72312	1.806876e-10	9.743
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	7.597595e-10	9.119
HSF1-dependent transactivation	R-HSA-3371571	3.086350e-09	8.511
Apoptotic execution phase	R-HSA-75153	5.340151e-09	8.272
Translation initiation complex formation	R-HSA-72649	6.549074e-09	8.184
Ribosomal scanning and start codon recognition	R-HSA-72702	1.056156e-08	7.976
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	1.242959e-08	7.906
Cellular response to heat stress	R-HSA-3371556	1.538356e-08	7.813
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.673585e-08	7.776
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.399100e-08	7.469
Attenuation phase	R-HSA-3371568	3.511526e-08	7.455
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.612095e-07	6.793
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.274018e-07	6.485
Translation	R-HSA-72766	3.926989e-07	6.406
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	4.504242e-07	6.346
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.116645e-06	5.952
Viral Infection Pathways	R-HSA-9824446	2.578967e-06	5.589
Cell-Cell communication	R-HSA-1500931	2.752929e-06	5.560
mRNA Splicing - Major Pathway	R-HSA-72163	2.818630e-06	5.550
HSF1 activation	R-HSA-3371511	3.147185e-06	5.502
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.762252e-06	5.322
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.721525e-06	5.242
Cell junction organization	R-HSA-446728	6.909244e-06	5.161
mRNA Splicing	R-HSA-72172	7.225142e-06	5.141
M Phase	R-HSA-68886	1.504304e-05	4.823
Developmental Biology	R-HSA-1266738	1.860603e-05	4.730
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.971143e-05	4.705
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.224350e-05	4.653
Mitotic Prophase	R-HSA-68875	2.741254e-05	4.562
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.756759e-05	4.560
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.756759e-05	4.560
Chromatin organization	R-HSA-4839726	3.231065e-05	4.491
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.829062e-05	4.417
SARS-CoV-1-host interactions	R-HSA-9692914	5.166624e-05	4.287
Cell Cycle, Mitotic	R-HSA-69278	5.692661e-05	4.245
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	6.390220e-05	4.194
Chromatin modifying enzymes	R-HSA-3247509	6.728646e-05	4.172
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	8.212185e-05	4.086
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	9.652339e-05	4.015
SARS-CoV-2-host interactions	R-HSA-9705683	1.071664e-04	3.970
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.543189e-04	3.812
Adherens junctions interactions	R-HSA-418990	3.052239e-04	3.515
Cell Cycle	R-HSA-1640170	3.846303e-04	3.415
Signaling by VEGF	R-HSA-194138	4.046204e-04	3.393
Cell-cell junction organization	R-HSA-421270	4.359766e-04	3.361
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	4.610764e-04	3.336
UCH proteinases	R-HSA-5689603	4.766949e-04	3.322
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.079795e-04	3.294
DCC mediated attractive signaling	R-HSA-418885	4.882824e-04	3.311
Signaling by RAS mutants	R-HSA-6802949	5.491347e-04	3.260
Signaling downstream of RAS mutants	R-HSA-9649948	5.491347e-04	3.260
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.491347e-04	3.260
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.491347e-04	3.260
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	5.195682e-04	3.284
Signaling by ALK in cancer	R-HSA-9700206	5.195682e-04	3.284
Apoptosis induced DNA fragmentation	R-HSA-140342	6.008389e-04	3.221
Regulation of CDH1 Function	R-HSA-9764561	6.198403e-04	3.208
Nuclear Envelope Breakdown	R-HSA-2980766	6.198403e-04	3.208
Regulation of CDH1 Gene Transcription	R-HSA-9764560	8.145548e-04	3.089
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.013527e-03	2.994
Signaling by RAF1 mutants	R-HSA-9656223	1.081530e-03	2.966
Apoptosis	R-HSA-109581	1.182615e-03	2.927
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.188054e-03	2.925
SARS-CoV-1 Infection	R-HSA-9678108	1.239893e-03	2.907
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.241207e-03	2.906
ISG15 antiviral mechanism	R-HSA-1169408	1.370264e-03	2.863
RAF activation	R-HSA-5673000	1.385728e-03	2.858
Interleukin-12 signaling	R-HSA-9020591	1.512373e-03	2.820
Interleukin-12 family signaling	R-HSA-447115	1.569617e-03	2.804
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.575747e-03	2.803
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.608667e-03	2.794
EPHB-mediated forward signaling	R-HSA-3928662	1.617559e-03	2.791
RMTs methylate histone arginines	R-HSA-3214858	1.617559e-03	2.791
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.724120e-03	2.763
Infectious disease	R-HSA-5663205	1.840340e-03	2.735
HATs acetylate histones	R-HSA-3214847	1.864916e-03	2.729
HCMV Early Events	R-HSA-9609690	1.920315e-03	2.717
Membrane Trafficking	R-HSA-199991	1.959574e-03	2.708
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.114129e-03	2.675
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.139263e-03	2.670
PKR-mediated signaling	R-HSA-9833482	2.207719e-03	2.656
Transcriptional regulation by RUNX1	R-HSA-8878171	2.264088e-03	2.645
Type I hemidesmosome assembly	R-HSA-446107	2.595137e-03	2.586
EPH-Ephrin signaling	R-HSA-2682334	2.632032e-03	2.580
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.798546e-03	2.553
SARS-CoV-2 Infection	R-HSA-9694516	2.948913e-03	2.530
Signaling by ERBB2	R-HSA-1227986	2.954535e-03	2.530
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.108936e-03	2.507
Transcriptional regulation by small RNAs	R-HSA-5578749	3.108936e-03	2.507
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	3.128575e-03	2.505
Cell-extracellular matrix interactions	R-HSA-446353	3.128575e-03	2.505
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	3.182640e-03	2.497
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.182640e-03	2.497
GP1b-IX-V activation signalling	R-HSA-430116	3.532642e-03	2.452
Interferon Signaling	R-HSA-913531	3.520484e-03	2.453
Mitotic Prometaphase	R-HSA-68877	3.473164e-03	2.459
PKMTs methylate histone lysines	R-HSA-3214841	3.606481e-03	2.443
Cellular Senescence	R-HSA-2559583	3.657983e-03	2.437
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.768516e-03	2.424
mRNA 3'-end processing	R-HSA-72187	4.126088e-03	2.384
Post NMDA receptor activation events	R-HSA-438064	4.380290e-03	2.358
Clathrin-mediated endocytosis	R-HSA-8856828	4.390625e-03	2.357
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	4.814842e-03	2.317
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.743079e-03	2.324
MAPK family signaling cascades	R-HSA-5683057	4.914973e-03	2.308
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	4.676974e-03	2.330
Signal Transduction	R-HSA-162582	4.762053e-03	2.322
Signaling by SCF-KIT	R-HSA-1433557	5.143393e-03	2.289
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	5.543753e-03	2.256
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.551446e-03	2.256
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.909023e-03	2.228
Signaling by MET	R-HSA-6806834	6.212695e-03	2.207
Metalloprotease DUBs	R-HSA-5689901	6.440812e-03	2.191
Separation of Sister Chromatids	R-HSA-2467813	6.591005e-03	2.181
Programmed Cell Death	R-HSA-5357801	6.652326e-03	2.177
PRC2 methylates histones and DNA	R-HSA-212300	7.104978e-03	2.148
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	7.104978e-03	2.148
Depolymerization of the Nuclear Lamina	R-HSA-4419969	6.903518e-03	2.161
RNA Polymerase I Promoter Opening	R-HSA-73728	7.429339e-03	2.129
RUNX2 regulates bone development	R-HSA-8941326	7.104978e-03	2.148
Recycling pathway of L1	R-HSA-437239	7.916089e-03	2.101
Regulation of signaling by CBL	R-HSA-912631	8.199067e-03	2.086
Cytokine Signaling in Immune system	R-HSA-1280215	8.360526e-03	2.078
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	8.483110e-03	2.071
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.522891e-03	2.069
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	8.972541e-03	2.047
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	8.972541e-03	2.047
Kinesins	R-HSA-983189	8.972541e-03	2.047
Oncogenic MAPK signaling	R-HSA-6802957	9.140233e-03	2.039
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	9.574594e-03	2.019
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	9.654088e-03	2.015
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.104807e-02	1.957
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.104807e-02	1.957
Breakdown of the nuclear lamina	R-HSA-352238	1.048666e-02	1.979
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.059156e-02	1.975
RNA Polymerase II Transcription Termination	R-HSA-73856	9.796171e-03	2.009
Mitotic Anaphase	R-HSA-68882	1.092533e-02	1.962
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.031859e-02	1.986
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.002701e-02	1.999
G2/M Transition	R-HSA-69275	1.017750e-02	1.992
Epigenetic regulation of gene expression	R-HSA-212165	1.106157e-02	1.956
Mitotic G2-G2/M phases	R-HSA-453274	1.116894e-02	1.952
Nef and signal transduction	R-HSA-164944	1.132021e-02	1.946
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.140353e-02	1.943
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.161286e-02	1.935
Signaling by PTK6	R-HSA-8848021	1.161286e-02	1.935
Selective autophagy	R-HSA-9663891	1.216927e-02	1.915
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.249088e-02	1.903
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.249088e-02	1.903
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.249088e-02	1.903
Host Interactions of HIV factors	R-HSA-162909	1.258961e-02	1.900
Estrogen-dependent gene expression	R-HSA-9018519	1.330003e-02	1.876
PCP/CE pathway	R-HSA-4086400	1.399472e-02	1.854
Meiotic synapsis	R-HSA-1221632	1.399879e-02	1.854
Regulation of KIT signaling	R-HSA-1433559	1.412068e-02	1.850
SOS-mediated signalling	R-HSA-112412	1.496396e-02	1.825
IPs transport between nucleus and cytosol	R-HSA-1855170	1.576372e-02	1.802
HDACs deacetylate histones	R-HSA-3214815	1.663097e-02	1.779
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	1.506150e-02	1.822
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.496396e-02	1.825
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.451559e-02	1.838
Signaling by KIT in disease	R-HSA-9669938	1.506150e-02	1.822
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.685755e-02	1.773
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.702705e-02	1.769
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.724561e-02	1.763
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.760389e-02	1.754
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.760389e-02	1.754
Platelet activation, signaling and aggregation	R-HSA-76002	1.767189e-02	1.753
Assembly of the pre-replicative complex	R-HSA-68867	1.807225e-02	1.743
Signaling by EGFR	R-HSA-177929	1.807290e-02	1.743
Formation of annular gap junctions	R-HSA-196025	1.919503e-02	1.717
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.919503e-02	1.717
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.958627e-02	1.708
Nuclear import of Rev protein	R-HSA-180746	1.958627e-02	1.708
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.958627e-02	1.708
DAG and IP3 signaling	R-HSA-1489509	2.009712e-02	1.697
Gap junction degradation	R-HSA-190873	2.401947e-02	1.619
WNT mediated activation of DVL	R-HSA-201688	2.401947e-02	1.619
ATP-dependent chromatin remodelers	R-HSA-9932444	2.219194e-02	1.654
SWI/SNF chromatin remodelers	R-HSA-9932451	2.219194e-02	1.654
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.171534e-02	1.663
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.401299e-02	1.620
Amplification of signal from the kinetochores	R-HSA-141424	2.401299e-02	1.620
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	2.394147e-02	1.621
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.113108e-02	1.675
HCMV Infection	R-HSA-9609646	2.279178e-02	1.642
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.401947e-02	1.619
Developmental Cell Lineages	R-HSA-9734767	2.078809e-02	1.682
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.196109e-02	1.658
MAPK6/MAPK4 signaling	R-HSA-5687128	2.253868e-02	1.647
Calmodulin induced events	R-HSA-111933	2.399534e-02	1.620
CaM pathway	R-HSA-111997	2.399534e-02	1.620
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.122164e-02	1.673
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.326958e-02	1.633
ESR-mediated signaling	R-HSA-8939211	2.499270e-02	1.602
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	2.604126e-02	1.584
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.643020e-02	1.578
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.725767e-02	1.565
Packaging Of Telomere Ends	R-HSA-171306	2.798764e-02	1.553
Non-integrin membrane-ECM interactions	R-HSA-3000171	2.816462e-02	1.550
Gap junction trafficking and regulation	R-HSA-157858	2.826333e-02	1.549
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.864786e-02	1.543
Glycolysis	R-HSA-70171	2.895373e-02	1.538
MET promotes cell motility	R-HSA-8875878	2.902357e-02	1.537
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.902357e-02	1.537
RAF/MAP kinase cascade	R-HSA-5673001	2.925281e-02	1.534
EGFR Transactivation by Gastrin	R-HSA-2179392	2.943772e-02	1.531
PI3K/AKT activation	R-HSA-198203	2.943772e-02	1.531
MET activates RAP1 and RAC1	R-HSA-8875555	2.943772e-02	1.531
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.943772e-02	1.531
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	3.075300e-02	1.512
Loss of Nlp from mitotic centrosomes	R-HSA-380259	3.075300e-02	1.512
Ephrin signaling	R-HSA-3928664	3.098076e-02	1.509
Chaperone Mediated Autophagy	R-HSA-9613829	3.098076e-02	1.509
TCF dependent signaling in response to WNT	R-HSA-201681	3.225694e-02	1.491
Intracellular signaling by second messengers	R-HSA-9006925	3.351437e-02	1.475
PLCG1 events in ERBB2 signaling	R-HSA-1251932	3.797721e-02	1.420
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.544525e-02	1.450
DNA methylation	R-HSA-5334118	3.466240e-02	1.460
EGFR downregulation	R-HSA-182971	4.224378e-02	1.374
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.469890e-02	1.460
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	3.842573e-02	1.415
AURKA Activation by TPX2	R-HSA-8854518	3.769793e-02	1.424
Aggrephagy	R-HSA-9646399	3.469890e-02	1.460
MAP2K and MAPK activation	R-HSA-5674135	4.104429e-02	1.387
Trafficking of AMPA receptors	R-HSA-399719	4.224378e-02	1.374
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	3.469890e-02	1.460
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	3.778661e-02	1.423
Negative regulation of MET activity	R-HSA-6807004	4.002677e-02	1.398
Golgi-to-ER retrograde transport	R-HSA-8856688	4.256873e-02	1.371
MAPK1/MAPK3 signaling	R-HSA-5684996	3.631792e-02	1.440
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	3.778661e-02	1.423
MTF1 activates gene expression	R-HSA-5660489	3.797721e-02	1.420
Activation of RAC1	R-HSA-428540	4.203332e-02	1.376
Downstream signal transduction	R-HSA-186763	4.224378e-02	1.374
Protein hydroxylation	R-HSA-9629569	4.002677e-02	1.398
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.587500e-02	1.445
Transcriptional regulation by RUNX2	R-HSA-8878166	4.240426e-02	1.373
L1CAM interactions	R-HSA-373760	3.679456e-02	1.434
Interactions of Rev with host cellular proteins	R-HSA-177243	3.469890e-02	1.460
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.778661e-02	1.423
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	4.104429e-02	1.387
Gene Silencing by RNA	R-HSA-211000	4.388305e-02	1.358
Ca-dependent events	R-HSA-111996	4.447401e-02	1.352
Cleavage of the damaged pyrimidine	R-HSA-110329	4.447401e-02	1.352
Depyrimidination	R-HSA-73928	4.447401e-02	1.352
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.505491e-02	1.346
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.505491e-02	1.346
Deubiquitination	R-HSA-5688426	4.558284e-02	1.341
SARS-CoV Infections	R-HSA-9679506	4.558635e-02	1.341
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	4.638027e-02	1.334
Ion homeostasis	R-HSA-5578775	4.744580e-02	1.324
Defective pyroptosis	R-HSA-9710421	4.807746e-02	1.318
DNA Replication Pre-Initiation	R-HSA-69002	4.831462e-02	1.316
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	4.918946e-02	1.308
p75NTR recruits signalling complexes	R-HSA-209543	4.918946e-02	1.308
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	4.953084e-02	1.305
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.990449e-02	1.302
Cell Cycle Checkpoints	R-HSA-69620	4.995113e-02	1.301
IRS activation	R-HSA-74713	5.002098e-02	1.301
FLT3 signaling by CBL mutants	R-HSA-9706377	5.002098e-02	1.301
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.002098e-02	1.301
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	5.002098e-02	1.301
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	5.041943e-02	1.297
Listeria monocytogenes entry into host cells	R-HSA-8876384	5.041943e-02	1.297
Signaling by PDGFR in disease	R-HSA-9671555	5.041943e-02	1.297
Integrin signaling	R-HSA-354192	5.074915e-02	1.295
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	5.074915e-02	1.295
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.074915e-02	1.295
Assembly of the ORC complex at the origin of replication	R-HSA-68616	5.074915e-02	1.295
Maternal to zygotic transition (MZT)	R-HSA-9816359	5.077333e-02	1.294
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	5.147260e-02	1.288
Gap junction trafficking	R-HSA-190828	5.185603e-02	1.285
Netrin-1 signaling	R-HSA-373752	5.185603e-02	1.285
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.185603e-02	1.285
Vesicle-mediated transport	R-HSA-5653656	5.387322e-02	1.269
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	5.476820e-02	1.261
Striated Muscle Contraction	R-HSA-390522	5.535100e-02	1.257
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	6.514101e-02	1.186
Erythropoietin activates RAS	R-HSA-9027284	7.389774e-02	1.131
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	5.778380e-02	1.238
Centrosome maturation	R-HSA-380287	6.456426e-02	1.190
Condensation of Prophase Chromosomes	R-HSA-2299718	5.994231e-02	1.222
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.939500e-02	1.159
Regulation of endogenous retroelements	R-HSA-9842860	6.651010e-02	1.177
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.581075e-02	1.253
Nucleosome assembly	R-HSA-774815	5.581075e-02	1.253
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	5.581075e-02	1.253
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.850609e-02	1.164
mTORC1-mediated signalling	R-HSA-166208	5.611842e-02	1.251
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	6.018582e-02	1.221
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	7.389774e-02	1.131
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	7.389774e-02	1.131
Mitotic Spindle Checkpoint	R-HSA-69618	6.062794e-02	1.217
p75NTR signals via NF-kB	R-HSA-193639	7.389774e-02	1.131
Mitophagy	R-HSA-5205647	6.018582e-02	1.221
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	5.581075e-02	1.253
Viral Messenger RNA Synthesis	R-HSA-168325	6.526456e-02	1.185
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	7.243733e-02	1.140
GPVI-mediated activation cascade	R-HSA-114604	7.055145e-02	1.151
Regulation of PTEN gene transcription	R-HSA-8943724	6.141778e-02	1.212
Semaphorin interactions	R-HSA-373755	7.338576e-02	1.134
Co-stimulation by CD28	R-HSA-389356	6.873709e-02	1.163
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.338576e-02	1.134
Spry regulation of FGF signaling	R-HSA-1295596	7.389774e-02	1.131
Signaling by WNT	R-HSA-195721	6.123995e-02	1.213
Interleukin-6 signaling	R-HSA-1059683	5.689811e-02	1.245
Protein methylation	R-HSA-8876725	7.389774e-02	1.131
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.778380e-02	1.238
tRNA processing in the nucleus	R-HSA-6784531	6.925384e-02	1.160
Oxidative Stress Induced Senescence	R-HSA-2559580	6.651010e-02	1.177
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	6.914982e-02	1.160
Growth hormone receptor signaling	R-HSA-982772	6.214874e-02	1.207
Pre-NOTCH Transcription and Translation	R-HSA-1912408	7.280554e-02	1.138
Signaling by Interleukins	R-HSA-449147	6.494240e-02	1.187
Diseases of programmed cell death	R-HSA-9645723	6.287850e-02	1.201
Metabolism of amino acids and derivatives	R-HSA-71291	5.696558e-02	1.244
Glucose metabolism	R-HSA-70326	7.499307e-02	1.125
Long-term potentiation	R-HSA-9620244	7.518512e-02	1.124
Regulation of T cell activation by CD28 family	R-HSA-388841	7.556742e-02	1.122
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	7.562414e-02	1.121
Degradation of DVL	R-HSA-4641258	7.607937e-02	1.119
SIRT1 negatively regulates rRNA expression	R-HSA-427359	7.607937e-02	1.119
Cleavage of the damaged purine	R-HSA-110331	7.607937e-02	1.119
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	7.699405e-02	1.114
Autointegration results in viral DNA circles	R-HSA-177539	7.746495e-02	1.111
Integration of viral DNA into host genomic DNA	R-HSA-175567	7.746495e-02	1.111
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	7.746495e-02	1.111
Ion transport by P-type ATPases	R-HSA-936837	7.766024e-02	1.110
Regulation of RAS by GAPs	R-HSA-5658442	7.823930e-02	1.107
Depurination	R-HSA-73927	8.183452e-02	1.087
Signaling by EGFR in Cancer	R-HSA-1643713	8.217948e-02	1.085
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.314602e-02	1.080
Killing mechanisms	R-HSA-9664420	8.314602e-02	1.080
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.314602e-02	1.080
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	8.359268e-02	1.078
HIV Infection	R-HSA-162906	8.474676e-02	1.072
Signaling by NTRKs	R-HSA-166520	8.580788e-02	1.066
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.781413e-02	1.056
Orc1 removal from chromatin	R-HSA-68949	8.844269e-02	1.053
Muscle contraction	R-HSA-397014	8.850200e-02	1.053
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	8.948192e-02	1.048
Disinhibition of SNARE formation	R-HSA-114516	9.258687e-02	1.033
Activated NTRK3 signals through PI3K	R-HSA-9603381	9.258687e-02	1.033
Uptake and function of diphtheria toxin	R-HSA-5336415	9.258687e-02	1.033
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	9.258687e-02	1.033
GRB2 events in ERBB2 signaling	R-HSA-1963640	9.286211e-02	1.032
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	9.286211e-02	1.032
Diseases of Telomere Maintenance	R-HSA-9673013	9.661123e-02	1.015
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	9.661123e-02	1.015
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	9.661123e-02	1.015
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	9.661123e-02	1.015
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	9.661123e-02	1.015
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	9.661123e-02	1.015
Formation of editosomes by ADAR proteins	R-HSA-77042	9.661123e-02	1.015
Inhibition of PKR	R-HSA-169131	9.661123e-02	1.015
Activation of AMPK downstream of NMDARs	R-HSA-9619483	9.708435e-02	1.013
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	9.793138e-02	1.009
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.933613e-02	1.003
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.004333e-01	0.998
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	1.011541e-01	0.995
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.030211e-01	0.987
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.030211e-01	0.987
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.030211e-01	0.987
Signaling by Hippo	R-HSA-2028269	1.030211e-01	0.987
Death Receptor Signaling	R-HSA-73887	1.047897e-01	0.980
Signaling by Erythropoietin	R-HSA-9006335	1.049780e-01	0.979
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.050368e-01	0.979
Meiosis	R-HSA-1500620	1.055854e-01	0.976
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.057020e-01	0.976
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.057020e-01	0.976
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.057020e-01	0.976
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.062710e-01	0.974
Negative regulation of MAPK pathway	R-HSA-5675221	1.070649e-01	0.970
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	1.084749e-01	0.965
Adrenoceptors	R-HSA-390696	1.084749e-01	0.965
Downregulation of ERBB4 signaling	R-HSA-1253288	1.084749e-01	0.965
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.084749e-01	0.965
Activated NTRK2 signals through FYN	R-HSA-9032500	1.084749e-01	0.965
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	1.084749e-01	0.965
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	1.084749e-01	0.965
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.084749e-01	0.965
NRAGE signals death through JNK	R-HSA-193648	1.109038e-01	0.955
NoRC negatively regulates rRNA expression	R-HSA-427413	1.115244e-01	0.953
Autophagy	R-HSA-9612973	1.116344e-01	0.952
p75 NTR receptor-mediated signalling	R-HSA-193704	1.125112e-01	0.949
Macroautophagy	R-HSA-1632852	1.127464e-01	0.948
Downregulation of ERBB2 signaling	R-HSA-8863795	1.131532e-01	0.946
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.135139e-01	0.945
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.135974e-01	0.945
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.135974e-01	0.945
Transport of connexons to the plasma membrane	R-HSA-190872	1.135974e-01	0.945
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.139052e-01	0.943
Defective VWF binding to collagen type I	R-HSA-9845622	1.413623e-01	0.850
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	1.413623e-01	0.850
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	1.413623e-01	0.850
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	1.250163e-01	0.903
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.596537e-01	0.797
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.595426e-01	0.797
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.216000e-01	0.915
FGFR2 alternative splicing	R-HSA-6803529	1.718047e-01	0.765
Regulation of Apoptosis	R-HSA-169911	1.675197e-01	0.776
G alpha (12/13) signalling events	R-HSA-416482	1.519602e-01	0.818
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.250163e-01	0.903
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	1.294742e-01	0.888
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.646209e-01	0.784
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	1.245644e-01	0.905
HIV Life Cycle	R-HSA-162587	1.151532e-01	0.939
Manipulation of host energy metabolism	R-HSA-9636667	1.413623e-01	0.850
Inactivation of CDC42 and RAC1	R-HSA-428543	1.250163e-01	0.903
Unwinding of DNA	R-HSA-176974	1.250163e-01	0.903
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.595426e-01	0.797
Degradation of CDH1	R-HSA-9766229	1.671740e-01	0.777
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.675197e-01	0.776
Pexophagy	R-HSA-9664873	1.421075e-01	0.847
Signal attenuation	R-HSA-74749	1.421075e-01	0.847
Receptor Mediated Mitophagy	R-HSA-8934903	1.421075e-01	0.847
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.718047e-01	0.765
Regulation of IFNA/IFNB signaling	R-HSA-912694	1.718047e-01	0.765
DNA Replication	R-HSA-69306	1.665600e-01	0.778
Beta-catenin independent WNT signaling	R-HSA-3858494	1.611588e-01	0.793
Signaling by NOTCH	R-HSA-157118	1.194973e-01	0.923
2-LTR circle formation	R-HSA-164843	1.421075e-01	0.847
Metabolism of non-coding RNA	R-HSA-194441	1.294742e-01	0.888
snRNP Assembly	R-HSA-191859	1.294742e-01	0.888
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.590297e-01	0.799
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.397748e-01	0.855
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.250163e-01	0.903
Suppression of apoptosis	R-HSA-9635465	1.596537e-01	0.797
Signaling by FGFR2	R-HSA-5654738	1.646209e-01	0.784
Signaling by NTRK3 (TRKC)	R-HSA-9034015	1.595426e-01	0.797
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.173590e-01	0.930
PLC beta mediated events	R-HSA-112043	1.426304e-01	0.846
RNA Polymerase I Transcription	R-HSA-73864	1.519602e-01	0.818
MHC class II antigen presentation	R-HSA-2132295	1.645280e-01	0.784
ChREBP activates metabolic gene expression	R-HSA-163765	1.596537e-01	0.797
PECAM1 interactions	R-HSA-210990	1.596537e-01	0.797
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.595426e-01	0.797
Regulation of MECP2 expression and activity	R-HSA-9022692	1.392652e-01	0.856
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.475640e-01	0.831
Signaling by Leptin	R-HSA-2586552	1.421075e-01	0.847
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.494306e-01	0.826
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.838990e-01	0.735
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.838990e-01	0.735
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.838990e-01	0.735
Defective ALG9 causes CDG-1l	R-HSA-4720454	1.838990e-01	0.735
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.838990e-01	0.735
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	1.838990e-01	0.735
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.838990e-01	0.735
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.838990e-01	0.735
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.838990e-01	0.735
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.838990e-01	0.735
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.838990e-01	0.735
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.838990e-01	0.735
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	1.838990e-01	0.735
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.838990e-01	0.735
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	1.838990e-01	0.735
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.838990e-01	0.735
Signaling by RAS GAP mutants	R-HSA-9753510	1.838990e-01	0.735
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.243310e-01	0.649
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.243310e-01	0.649
HCN channels	R-HSA-1296061	2.627622e-01	0.580
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	2.627622e-01	0.580
Defective LFNG causes SCDO3	R-HSA-5083630	2.627622e-01	0.580
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.627622e-01	0.580
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.627622e-01	0.580
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.992914e-01	0.524
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	2.992914e-01	0.524
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	2.992914e-01	0.524
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.775679e-01	0.751
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.957710e-01	0.708
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.957710e-01	0.708
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.957710e-01	0.708
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	3.340128e-01	0.476
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.340128e-01	0.476
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	3.340128e-01	0.476
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	3.340128e-01	0.476
Noncanonical activation of NOTCH3	R-HSA-9017802	3.340128e-01	0.476
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.340128e-01	0.476
Platelet Adhesion to exposed collagen	R-HSA-75892	2.141903e-01	0.669
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	2.141903e-01	0.669
Formation of axial mesoderm	R-HSA-9796292	2.141903e-01	0.669
Membrane binding and targetting of GAG proteins	R-HSA-174490	2.141903e-01	0.669
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.141903e-01	0.669
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.141903e-01	0.669
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.141903e-01	0.669
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.327599e-01	0.633
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	2.327599e-01	0.633
SHC1 events in EGFR signaling	R-HSA-180336	2.514199e-01	0.600
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.514199e-01	0.600
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.843237e-01	0.734
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.970736e-01	0.705
Deadenylation of mRNA	R-HSA-429947	1.970736e-01	0.705
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.701157e-01	0.568
MET activates PTK2 signaling	R-HSA-8874081	2.231642e-01	0.651
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.364554e-01	0.626
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.364554e-01	0.626
Cristae formation	R-HSA-8949613	2.364554e-01	0.626
PI3K events in ERBB2 signaling	R-HSA-1963642	3.074228e-01	0.512
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.074228e-01	0.512
HIV elongation arrest and recovery	R-HSA-167287	2.498789e-01	0.602
Pausing and recovery of HIV elongation	R-HSA-167290	2.498789e-01	0.602
RNA Polymerase III Transcription Termination	R-HSA-73980	3.259495e-01	0.487
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.634117e-01	0.579
Late endosomal microautophagy	R-HSA-9615710	2.634117e-01	0.579
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.770317e-01	0.557
Activation of the pre-replicative complex	R-HSA-68962	2.770317e-01	0.557
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.443423e-01	0.463
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.907178e-01	0.537
Diseases of mitotic cell cycle	R-HSA-9675126	3.044496e-01	0.516
Neutrophil degranulation	R-HSA-6798695	3.147248e-01	0.502
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.912737e-01	0.718
Ub-specific processing proteases	R-HSA-5689880	1.844342e-01	0.734
Processing of DNA double-strand break ends	R-HSA-5693607	3.004366e-01	0.522
Degradation of GLI1 by the proteasome	R-HSA-5610780	2.399303e-01	0.620
COPI-mediated anterograde transport	R-HSA-6807878	3.035480e-01	0.518
GAB1 signalosome	R-HSA-180292	3.259495e-01	0.487
Germ layer formation at gastrulation	R-HSA-9754189	3.443423e-01	0.463
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	2.327599e-01	0.633
p38MAPK events	R-HSA-171007	2.514199e-01	0.600
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.562307e-01	0.591
DNA Damage Bypass	R-HSA-73893	3.293252e-01	0.482
G1 Phase	R-HSA-69236	2.729271e-01	0.564
Cyclin D associated events in G1	R-HSA-69231	2.729271e-01	0.564
Regulation of gap junction activity	R-HSA-191650	2.627622e-01	0.580
NF-kB is activated and signals survival	R-HSA-209560	1.775679e-01	0.751
Regulation of IFNG signaling	R-HSA-877312	1.957710e-01	0.708
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.957710e-01	0.708
EPHA-mediated growth cone collapse	R-HSA-3928663	2.364554e-01	0.626
IRS-related events triggered by IGF1R	R-HSA-2428928	2.753097e-01	0.560
Activation of HOX genes during differentiation	R-HSA-5619507	2.408240e-01	0.618
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.408240e-01	0.618
Integration of provirus	R-HSA-162592	1.775679e-01	0.751
DNA Double Strand Break Response	R-HSA-5693606	3.339844e-01	0.476
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	2.860170e-01	0.544
Late Phase of HIV Life Cycle	R-HSA-162599	1.960273e-01	0.708
Switching of origins to a post-replicative state	R-HSA-69052	2.326744e-01	0.633
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.992914e-01	0.524
Activation of AKT2	R-HSA-165158	2.992914e-01	0.524
PTK6 Down-Regulation	R-HSA-8849472	2.992914e-01	0.524
GRB2 events in EGFR signaling	R-HSA-179812	1.957710e-01	0.708
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	3.259495e-01	0.487
Regulation of RUNX3 expression and activity	R-HSA-8941858	2.184828e-01	0.661
IRS-mediated signalling	R-HSA-112399	2.374924e-01	0.624
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	2.514199e-01	0.600
Synaptic adhesion-like molecules	R-HSA-8849932	3.259495e-01	0.487
ER to Golgi Anterograde Transport	R-HSA-199977	3.313040e-01	0.480
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	2.992914e-01	0.524
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.340128e-01	0.476
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.364554e-01	0.626
Deadenylation-dependent mRNA decay	R-HSA-429914	2.562307e-01	0.591
IGF1R signaling cascade	R-HSA-2428924	3.044334e-01	0.517
MTOR signalling	R-HSA-165159	2.508315e-01	0.601
Ovarian tumor domain proteases	R-HSA-5689896	1.873866e-01	0.727
Asymmetric localization of PCP proteins	R-HSA-4608870	2.840975e-01	0.547
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	2.498789e-01	0.602
FGFR1 mutant receptor activation	R-HSA-1839124	3.182076e-01	0.497
Collagen formation	R-HSA-1474290	2.798982e-01	0.553
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	3.142460e-01	0.503
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	3.035480e-01	0.518
Interferon alpha/beta signaling	R-HSA-909733	2.140535e-01	0.669
Insulin receptor signalling cascade	R-HSA-74751	3.044334e-01	0.517
Parasite infection	R-HSA-9664407	2.796904e-01	0.553
Leishmania phagocytosis	R-HSA-9664417	2.796904e-01	0.553
FCGR3A-mediated phagocytosis	R-HSA-9664422	2.796904e-01	0.553
Signaling by FGFR1 in disease	R-HSA-5655302	2.399303e-01	0.620
mRNA Editing: A to I Conversion	R-HSA-75064	1.838990e-01	0.735
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.838990e-01	0.735
C6 deamination of adenosine	R-HSA-75102	1.838990e-01	0.735
NTRK2 activates RAC1	R-HSA-9032759	2.992914e-01	0.524
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	2.701157e-01	0.568
Interaction between L1 and Ankyrins	R-HSA-445095	2.364554e-01	0.626
Regulation of FZD by ubiquitination	R-HSA-4641263	3.074228e-01	0.512
Phase 0 - rapid depolarisation	R-HSA-5576892	2.498789e-01	0.602
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	3.259495e-01	0.487
RNA Polymerase I Promoter Escape	R-HSA-73772	1.925414e-01	0.715
PI3K Cascade	R-HSA-109704	3.407133e-01	0.468
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.798982e-01	0.553
Regulation of TNFR1 signaling	R-HSA-5357905	2.953338e-01	0.530
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.291433e-01	0.640
Circadian clock	R-HSA-9909396	3.402127e-01	0.468
Smooth Muscle Contraction	R-HSA-445355	2.012844e-01	0.696
NRIF signals cell death from the nucleus	R-HSA-205043	2.327599e-01	0.633
Coenzyme A biosynthesis	R-HSA-196783	2.887982e-01	0.539
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.498789e-01	0.602
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.634117e-01	0.579
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.307570e-01	0.637
Evasion by RSV of host interferon responses	R-HSA-9833109	2.907178e-01	0.537
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	1.775679e-01	0.751
Signaling by LTK	R-HSA-9842663	1.957710e-01	0.708
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.340128e-01	0.476
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.340128e-01	0.476
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	2.887982e-01	0.539
Meiotic recombination	R-HSA-912446	1.839371e-01	0.735
Negative regulation of FGFR1 signaling	R-HSA-5654726	3.182076e-01	0.497
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.182076e-01	0.497
Vpu mediated degradation of CD4	R-HSA-180534	3.319731e-01	0.479
Sema4D in semaphorin signaling	R-HSA-400685	2.100288e-01	0.678
Regulation of RUNX2 expression and activity	R-HSA-8939902	2.753097e-01	0.560
NGF-stimulated transcription	R-HSA-9031628	3.179587e-01	0.498
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.327599e-01	0.633
HCMV Late Events	R-HSA-9610379	2.802962e-01	0.552
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.970736e-01	0.705
Pre-NOTCH Expression and Processing	R-HSA-1912422	1.901553e-01	0.721
Cilium Assembly	R-HSA-5617833	1.831852e-01	0.737
TBC/RABGAPs	R-HSA-8854214	2.618345e-01	0.582
Sensory perception of sour taste	R-HSA-9729555	2.627622e-01	0.580
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	1.775679e-01	0.751
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	1.775679e-01	0.751
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.340128e-01	0.476
CD28 dependent Vav1 pathway	R-HSA-389359	2.141903e-01	0.669
The NLRP3 inflammasome	R-HSA-844456	3.443423e-01	0.463
Co-inhibition by PD-1	R-HSA-389948	2.291697e-01	0.640
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.247417e-01	0.488
Gene expression (Transcription)	R-HSA-74160	3.159402e-01	0.500
Histamine receptors	R-HSA-390650	2.243310e-01	0.649
Acetylcholine regulates insulin secretion	R-HSA-399997	2.887982e-01	0.539
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.873866e-01	0.727
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	2.950812e-01	0.530
Organelle biogenesis and maintenance	R-HSA-1852241	2.116063e-01	0.674
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.282703e-01	0.642
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	2.840975e-01	0.547
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	2.840975e-01	0.547
PIP3 activates AKT signaling	R-HSA-1257604	1.857683e-01	0.731
PTEN Regulation	R-HSA-6807070	2.734059e-01	0.563
RSV-host interactions	R-HSA-9833110	2.408240e-01	0.618
Hemostasis	R-HSA-109582	2.265259e-01	0.645
Negative regulation of FLT3	R-HSA-9706369	2.701157e-01	0.568
FLT3 signaling in disease	R-HSA-9682385	1.773584e-01	0.751
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.873866e-01	0.727
G2/M Checkpoints	R-HSA-69481	1.909255e-01	0.719
Cellular response to hypoxia	R-HSA-1234174	3.142460e-01	0.503
DAP12 signaling	R-HSA-2424491	2.770317e-01	0.557
Disease	R-HSA-1643685	2.164607e-01	0.665
Reproduction	R-HSA-1474165	3.262360e-01	0.486
Signaling by PDGF	R-HSA-186797	2.849578e-01	0.545
Maturation of nucleoprotein	R-HSA-9683610	2.141903e-01	0.669
Effects of PIP2 hydrolysis	R-HSA-114508	3.319731e-01	0.479
Signaling by FGFR4	R-HSA-5654743	2.618345e-01	0.582
Signaling by FGFR3	R-HSA-5654741	2.840975e-01	0.547
Interleukin-6 family signaling	R-HSA-6783589	1.970736e-01	0.705
FasL/ CD95L signaling	R-HSA-75157	2.243310e-01	0.649
Maturation of protein E	R-HSA-9694493	3.340128e-01	0.476
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.340128e-01	0.476
Maturation of protein E	R-HSA-9683683	3.340128e-01	0.476
Syndecan interactions	R-HSA-3000170	1.843237e-01	0.734
Signaling by FGFR	R-HSA-190236	3.195349e-01	0.495
G-protein mediated events	R-HSA-112040	1.854885e-01	0.732
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.327149e-01	0.633
Base Excision Repair	R-HSA-73884	2.416278e-01	0.617
Amyloid fiber formation	R-HSA-977225	3.004366e-01	0.522
Collagen chain trimerization	R-HSA-8948216	1.873866e-01	0.727
TRAIL signaling	R-HSA-75158	3.340128e-01	0.476
Response of Mtb to phagocytosis	R-HSA-9637690	2.618345e-01	0.582
Miscellaneous transport and binding events	R-HSA-5223345	3.319731e-01	0.479
Sensory processing of sound	R-HSA-9659379	2.831035e-01	0.548
Signaling by NOTCH4	R-HSA-9013694	2.408846e-01	0.618
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.775679e-01	0.751
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.340128e-01	0.476
Tie2 Signaling	R-HSA-210993	3.259495e-01	0.487
Maturation of nucleoprotein	R-HSA-9694631	3.443423e-01	0.463
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.930802e-01	0.714
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	3.182076e-01	0.497
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.970736e-01	0.705
Neurodegenerative Diseases	R-HSA-8863678	1.970736e-01	0.705
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.091774e-01	0.510
Signaling by NTRK2 (TRKB)	R-HSA-9006115	2.364554e-01	0.626
RET signaling	R-HSA-8853659	1.773584e-01	0.751
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.364554e-01	0.626
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.282703e-01	0.642
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	2.701157e-01	0.568
Insulin processing	R-HSA-264876	2.364554e-01	0.626
Gluconeogenesis	R-HSA-70263	3.179587e-01	0.498
Signal regulatory protein family interactions	R-HSA-391160	2.327599e-01	0.633
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.843237e-01	0.734
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.259495e-01	0.487
Response to metal ions	R-HSA-5660526	2.887982e-01	0.539
Dual Incision in GG-NER	R-HSA-5696400	3.457286e-01	0.461
Negative regulation of FGFR2 signaling	R-HSA-5654727	3.457286e-01	0.461
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	3.457286e-01	0.461
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	3.457286e-01	0.461
Gap junction assembly	R-HSA-190861	3.457286e-01	0.461
Rab regulation of trafficking	R-HSA-9007101	3.497510e-01	0.456
Activation of NF-kappaB in B cells	R-HSA-1169091	3.521127e-01	0.453
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	3.594573e-01	0.444
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	3.594573e-01	0.444
Signalling to ERKs	R-HSA-187687	3.594573e-01	0.444
Formation of ATP by chemiosmotic coupling	R-HSA-163210	3.625690e-01	0.441
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.625690e-01	0.441
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.625690e-01	0.441
Co-inhibition by CTLA4	R-HSA-389513	3.625690e-01	0.441
Signal transduction by L1	R-HSA-445144	3.625690e-01	0.441
VxPx cargo-targeting to cilium	R-HSA-5620916	3.625690e-01	0.441
Nephrin family interactions	R-HSA-373753	3.625690e-01	0.441
Glycogen synthesis	R-HSA-3322077	3.625690e-01	0.441
Formation of RNA Pol II elongation complex	R-HSA-112382	3.635135e-01	0.439
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	3.637687e-01	0.439
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.670157e-01	0.435
Erythropoietin activates STAT5	R-HSA-9027283	3.670157e-01	0.435
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	3.670157e-01	0.435
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	3.670157e-01	0.435
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.670157e-01	0.435
Signaling by LTK in cancer	R-HSA-9842640	3.670157e-01	0.435
NADPH regeneration	R-HSA-389542	3.670157e-01	0.435
Ion channel transport	R-HSA-983712	3.687347e-01	0.433
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.731431e-01	0.428
RNA Polymerase III Transcription	R-HSA-74158	3.731431e-01	0.428
Vif-mediated degradation of APOBEC3G	R-HSA-180585	3.731431e-01	0.428
Regulation of TP53 Degradation	R-HSA-6804757	3.731431e-01	0.428
C-type lectin receptors (CLRs)	R-HSA-5621481	3.732044e-01	0.428
Hedgehog 'on' state	R-HSA-5632684	3.737167e-01	0.427
Cargo trafficking to the periciliary membrane	R-HSA-5620920	3.737167e-01	0.427
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.749058e-01	0.426
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.749058e-01	0.426
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	3.806011e-01	0.420
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	3.806011e-01	0.420
TNFR1-induced proapoptotic signaling	R-HSA-5357786	3.806011e-01	0.420
Signalling to RAS	R-HSA-167044	3.806011e-01	0.420
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	3.806011e-01	0.420
Early Phase of HIV Life Cycle	R-HSA-162594	3.806011e-01	0.420
Nucleotide Excision Repair	R-HSA-5696398	3.845671e-01	0.415
Degradation of AXIN	R-HSA-4641257	3.867712e-01	0.413
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	3.867712e-01	0.413
Signaling by Nuclear Receptors	R-HSA-9006931	3.920834e-01	0.407
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	3.951988e-01	0.403
Signaling by NOTCH3	R-HSA-9012852	3.976283e-01	0.401
G alpha (z) signalling events	R-HSA-418597	3.976283e-01	0.401
Transcriptional Regulation by MECP2	R-HSA-8986944	3.980816e-01	0.400
IFNG signaling activates MAPKs	R-HSA-9732724	3.983851e-01	0.400
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	R-HSA-964827	3.983851e-01	0.400
Cohesin Loading onto Chromatin	R-HSA-2470946	3.983851e-01	0.400
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	3.983851e-01	0.400
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.983851e-01	0.400
Regulation of PTEN localization	R-HSA-8948747	3.983851e-01	0.400
VLDL clearance	R-HSA-8964046	3.983851e-01	0.400
Cation-coupled Chloride cotransporters	R-HSA-426117	3.983851e-01	0.400
Netrin mediated repulsion signals	R-HSA-418886	3.983851e-01	0.400
CHL1 interactions	R-HSA-447041	3.983851e-01	0.400
Activated NTRK2 signals through CDK5	R-HSA-9032845	3.983851e-01	0.400
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.983851e-01	0.400
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	3.984129e-01	0.400
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.984129e-01	0.400
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	3.984129e-01	0.400
Assembly Of The HIV Virion	R-HSA-175474	3.984129e-01	0.400
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	3.984129e-01	0.400
G2/M DNA damage checkpoint	R-HSA-69473	4.035294e-01	0.394
Signaling by FGFR in disease	R-HSA-1226099	4.035294e-01	0.394
Signaling by ERBB4	R-HSA-1236394	4.035294e-01	0.394
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	4.089407e-01	0.388
TNF signaling	R-HSA-75893	4.089407e-01	0.388
Signaling by FGFR1	R-HSA-5654736	4.089407e-01	0.388
Detoxification of Reactive Oxygen Species	R-HSA-3299685	4.089407e-01	0.388
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.137983e-01	0.383
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	4.137983e-01	0.383
Transcriptional Regulation by E2F6	R-HSA-8953750	4.137983e-01	0.383
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.137983e-01	0.383
Stabilization of p53	R-HSA-69541	4.137983e-01	0.383
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.137983e-01	0.383
Signaling by ALK	R-HSA-201556	4.137983e-01	0.383
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	4.137983e-01	0.383
Signaling by Insulin receptor	R-HSA-74752	4.159343e-01	0.381
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	4.159823e-01	0.381
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	4.159823e-01	0.381
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.159823e-01	0.381
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	4.159823e-01	0.381
G1/S Transition	R-HSA-69206	4.179994e-01	0.379
TCR signaling	R-HSA-202403	4.254828e-01	0.371
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	4.271717e-01	0.369
HIV Transcription Elongation	R-HSA-167169	4.271717e-01	0.369
Formation of Incision Complex in GG-NER	R-HSA-5696395	4.271717e-01	0.369
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	4.271717e-01	0.369
Negative regulation of NOTCH4 signaling	R-HSA-9604323	4.271717e-01	0.369
EGFR interacts with phospholipase C-gamma	R-HSA-212718	4.282016e-01	0.368
Signaling by MRAS-complex mutants	R-HSA-9660537	4.282016e-01	0.368
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.282016e-01	0.368
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.282016e-01	0.368
Co-stimulation by ICOS	R-HSA-9927354	4.282016e-01	0.368
Myoclonic epilepsy of Lafora	R-HSA-3785653	4.282016e-01	0.368
Activation of RAS in B cells	R-HSA-1169092	4.282016e-01	0.368
Interleukin-9 signaling	R-HSA-8985947	4.282016e-01	0.368
ROBO receptors bind AKAP5	R-HSA-9010642	4.282016e-01	0.368
SLC-mediated bile acid transport	R-HSA-9958517	4.282016e-01	0.368
RSK activation	R-HSA-444257	4.282016e-01	0.368
Modulation by Mtb of host immune system	R-HSA-9637628	4.282016e-01	0.368
Platelet degranulation	R-HSA-114608	4.331764e-01	0.363
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	4.332893e-01	0.363
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	4.332893e-01	0.363
Hh mutants are degraded by ERAD	R-HSA-5362768	4.404357e-01	0.356
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	4.404357e-01	0.356
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	4.404357e-01	0.356
FLT3 Signaling	R-HSA-9607240	4.404357e-01	0.356
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.503170e-01	0.346
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	4.503170e-01	0.346
Degradation of CRY and PER proteins	R-HSA-9932298	4.535797e-01	0.343
Intra-Golgi traffic	R-HSA-6811438	4.535797e-01	0.343
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.535797e-01	0.343
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.535797e-01	0.343
SLC-mediated transport of neurotransmitters	R-HSA-442660	4.535797e-01	0.343
Translation of Structural Proteins	R-HSA-9683701	4.535797e-01	0.343
Negative regulation of the PI3K/AKT network	R-HSA-199418	4.558528e-01	0.341
Lipophagy	R-HSA-9613354	4.565421e-01	0.341
ALK mutants bind TKIs	R-HSA-9700645	4.565421e-01	0.341
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	4.565421e-01	0.341
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.565421e-01	0.341
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.565421e-01	0.341
Interleukin-21 signaling	R-HSA-9020958	4.565421e-01	0.341
mRNA Editing	R-HSA-75072	4.565421e-01	0.341
Regulation of CDH11 gene transcription	R-HSA-9762293	4.565421e-01	0.341
Respiratory syncytial virus genome replication	R-HSA-9834752	4.565421e-01	0.341
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	4.565421e-01	0.341
CLEC7A (Dectin-1) signaling	R-HSA-5607764	4.602248e-01	0.337
Collagen degradation	R-HSA-1442490	4.646928e-01	0.333
Tight junction interactions	R-HSA-420029	4.670506e-01	0.331
HDMs demethylate histones	R-HSA-3214842	4.670506e-01	0.331
Interleukin-7 signaling	R-HSA-1266695	4.670506e-01	0.331
Transcriptional regulation by RUNX3	R-HSA-8878159	4.689921e-01	0.329
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.689921e-01	0.329
Telomere Maintenance	R-HSA-157579	4.689921e-01	0.329
Adipogenesis	R-HSA-9843745	4.708812e-01	0.327
Mitochondrial protein import	R-HSA-1268020	4.756305e-01	0.323
NCAM signaling for neurite out-growth	R-HSA-375165	4.756305e-01	0.323
RNA Polymerase II Transcription	R-HSA-73857	4.768415e-01	0.322
Transmission across Chemical Synapses	R-HSA-112315	4.771386e-01	0.321
Hh mutants abrogate ligand secretion	R-HSA-5387390	4.794682e-01	0.319
MITF-M-dependent gene expression	R-HSA-9856651	4.819580e-01	0.317
Signaling by FLT3 fusion proteins	R-HSA-9703465	4.834773e-01	0.316
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	4.834773e-01	0.316
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.834773e-01	0.316
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	4.834773e-01	0.316
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	4.834773e-01	0.316
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	4.834773e-01	0.316
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.834796e-01	0.316
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.834796e-01	0.316
Folding of actin by CCT/TriC	R-HSA-390450	4.834796e-01	0.316
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	4.834796e-01	0.316
Regulation of CDH11 function	R-HSA-9762292	4.834796e-01	0.316
Josephin domain DUBs	R-HSA-5689877	4.834796e-01	0.316
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	4.834796e-01	0.316
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.834796e-01	0.316
Interleukin-27 signaling	R-HSA-9020956	4.834796e-01	0.316
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.834796e-01	0.316
G1/S DNA Damage Checkpoints	R-HSA-69615	4.864820e-01	0.313
Amine ligand-binding receptors	R-HSA-375280	4.921949e-01	0.308
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	4.921949e-01	0.308
DAP12 interactions	R-HSA-2172127	4.921949e-01	0.308
Metabolism of proteins	R-HSA-392499	4.930889e-01	0.307
Hedgehog 'off' state	R-HSA-5610787	4.950454e-01	0.305
Mitochondrial biogenesis	R-HSA-1592230	4.980710e-01	0.303
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.995864e-01	0.301
CD28 dependent PI3K/Akt signaling	R-HSA-389357	4.995864e-01	0.301
Extra-nuclear estrogen signaling	R-HSA-9009391	5.036355e-01	0.298
Interleukin-1 signaling	R-HSA-9020702	5.036355e-01	0.298
Defective CFTR causes cystic fibrosis	R-HSA-5678895	5.047659e-01	0.297
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	5.047659e-01	0.297
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	5.047659e-01	0.297
Homology Directed Repair	R-HSA-5693538	5.059763e-01	0.296
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	5.090835e-01	0.293
Activated NTRK3 signals through RAS	R-HSA-9034864	5.090835e-01	0.293
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.153693e-01	0.288
Formation of the Early Elongation Complex	R-HSA-113418	5.153693e-01	0.288
Inflammasomes	R-HSA-622312	5.153693e-01	0.288
mRNA Splicing - Minor Pathway	R-HSA-72165	5.171740e-01	0.286
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	5.171740e-01	0.286
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	5.171740e-01	0.286
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	5.171740e-01	0.286
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	5.195978e-01	0.284
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	5.288719e-01	0.277
Response of endothelial cells to shear stress	R-HSA-9860931	5.290786e-01	0.276
Opioid Signalling	R-HSA-111885	5.290786e-01	0.276
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	5.294127e-01	0.276
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	5.294127e-01	0.276
Chromosome Maintenance	R-HSA-73886	5.294307e-01	0.276
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.308185e-01	0.275
Signaling by CSF3 (G-CSF)	R-HSA-9674555	5.308185e-01	0.275
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.308185e-01	0.275
Synthesis of diphthamide-EEF2	R-HSA-5358493	5.334196e-01	0.273
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	5.334196e-01	0.273
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.334196e-01	0.273
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.334196e-01	0.273
Plasmalogen biosynthesis	R-HSA-75896	5.334196e-01	0.273
Sensing of DNA Double Strand Breaks	R-HSA-5693548	5.334196e-01	0.273
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	5.334196e-01	0.273
Anchoring fibril formation	R-HSA-2214320	5.334196e-01	0.273
Activated NTRK2 signals through RAS	R-HSA-9026519	5.334196e-01	0.273
Chaperonin-mediated protein folding	R-HSA-390466	5.380658e-01	0.269
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	5.392535e-01	0.268
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	5.459284e-01	0.263
RNA Polymerase III Transcription Initiation	R-HSA-76046	5.459284e-01	0.263
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	5.459284e-01	0.263
GABA synthesis, release, reuptake and degradation	R-HSA-888590	5.459284e-01	0.263
p53-Dependent G1 DNA Damage Response	R-HSA-69563	5.533594e-01	0.257
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	5.533594e-01	0.257
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.565507e-01	0.254
RUNX3 regulates p14-ARF	R-HSA-8951936	5.565507e-01	0.254
Serotonin clearance from the synaptic cleft	R-HSA-380615	5.565507e-01	0.254
Interleukin-35 Signalling	R-HSA-8984722	5.565507e-01	0.254
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	5.565507e-01	0.254
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	5.565507e-01	0.254
MET activates RAS signaling	R-HSA-8851805	5.565507e-01	0.254
IRAK1 recruits IKK complex	R-HSA-937039	5.565507e-01	0.254
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	5.565507e-01	0.254
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.565507e-01	0.254
VLDLR internalisation and degradation	R-HSA-8866427	5.565507e-01	0.254
SHC-related events triggered by IGF1R	R-HSA-2428933	5.565507e-01	0.254
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.565507e-01	0.254
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.565507e-01	0.254
OAS antiviral response	R-HSA-8983711	5.565507e-01	0.254
DNA Repair	R-HSA-73894	5.593033e-01	0.252
COPII-mediated vesicle transport	R-HSA-204005	5.595796e-01	0.252
Cyclin E associated events during G1/S transition	R-HSA-69202	5.595796e-01	0.252
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	5.606946e-01	0.251
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	5.606946e-01	0.251
Synthesis of DNA	R-HSA-69239	5.621328e-01	0.250
Downstream TCR signaling	R-HSA-202424	5.651342e-01	0.248
Transport to the Golgi and subsequent modification	R-HSA-948021	5.678285e-01	0.246
Regulation of mitotic cell cycle	R-HSA-453276	5.695587e-01	0.244
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.695587e-01	0.244
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	5.751142e-01	0.240
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	5.751142e-01	0.240
DNA strand elongation	R-HSA-69190	5.751142e-01	0.240
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	5.765661e-01	0.239
Hedgehog ligand biogenesis	R-HSA-5358346	5.765661e-01	0.239
The phototransduction cascade	R-HSA-2514856	5.765661e-01	0.239
Reversible hydration of carbon dioxide	R-HSA-1475029	5.785364e-01	0.238
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.785364e-01	0.238
Frs2-mediated activation	R-HSA-170968	5.785364e-01	0.238
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.785364e-01	0.238
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	5.794106e-01	0.237
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.794106e-01	0.237
Immune System	R-HSA-168256	5.831844e-01	0.234
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	5.878820e-01	0.231
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	5.878820e-01	0.231
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	5.878820e-01	0.231
Uptake and actions of bacterial toxins	R-HSA-5339562	5.878820e-01	0.231
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.891852e-01	0.230
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.891852e-01	0.230
Regulation of necroptotic cell death	R-HSA-5675482	5.891852e-01	0.230
Nuclear RNA decay	R-HSA-9930044	5.891852e-01	0.230
Activation of ATR in response to replication stress	R-HSA-176187	5.891852e-01	0.230
Cardiogenesis	R-HSA-9733709	5.891852e-01	0.230
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	5.891852e-01	0.230
Protein folding	R-HSA-391251	5.913722e-01	0.228
RNA Polymerase II Pre-transcription Events	R-HSA-674695	5.987213e-01	0.223
Golgi Associated Vesicle Biogenesis	R-HSA-432722	5.990020e-01	0.223
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	5.990020e-01	0.223
Regulation of PTEN stability and activity	R-HSA-8948751	5.990020e-01	0.223
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	5.994334e-01	0.222
N-glycan trimming and elongation in the cis-Golgi	R-HSA-964739	5.994334e-01	0.222
CRMPs in Sema3A signaling	R-HSA-399956	5.994334e-01	0.222
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	5.994334e-01	0.222
Retrograde neurotrophin signalling	R-HSA-177504	5.994334e-01	0.222
Respiratory syncytial virus genome transcription	R-HSA-9828642	5.994334e-01	0.222
HDL assembly	R-HSA-8963896	5.994334e-01	0.222
Signaling by FGFR4 in disease	R-HSA-5655291	5.994334e-01	0.222
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.994334e-01	0.222
Inositol phosphate metabolism	R-HSA-1483249	6.018319e-01	0.221
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	6.029067e-01	0.220
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	6.029067e-01	0.220
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.029067e-01	0.220
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	6.029067e-01	0.220
Glutamate and glutamine metabolism	R-HSA-8964539	6.029067e-01	0.220
Generic Transcription Pathway	R-HSA-212436	6.058915e-01	0.218
S Phase	R-HSA-69242	6.065837e-01	0.217
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	6.081747e-01	0.216
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	6.081747e-01	0.216
Mitochondrial protein degradation	R-HSA-9837999	6.083698e-01	0.216
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	6.099235e-01	0.215
Signaling by NOTCH2	R-HSA-1980145	6.162787e-01	0.210
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.162787e-01	0.210
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.162787e-01	0.210
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	6.171557e-01	0.210
Cellular responses to mechanical stimuli	R-HSA-9855142	6.171557e-01	0.210
Cardiac conduction	R-HSA-5576891	6.182871e-01	0.209
RNA Polymerase III Chain Elongation	R-HSA-73780	6.192954e-01	0.208
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.192954e-01	0.208
Translesion synthesis by REV1	R-HSA-110312	6.192954e-01	0.208
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	6.192954e-01	0.208
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.192954e-01	0.208
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.192954e-01	0.208
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.192954e-01	0.208
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.192954e-01	0.208
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	6.192954e-01	0.208
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	6.192954e-01	0.208
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.206442e-01	0.207
Translation of Structural Proteins	R-HSA-9694635	6.266668e-01	0.203
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.293022e-01	0.201
Oncogene Induced Senescence	R-HSA-2559585	6.293022e-01	0.201
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	6.311626e-01	0.200
MITF-M-regulated melanocyte development	R-HSA-9730414	6.367803e-01	0.196
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	6.381738e-01	0.195
Translesion synthesis by POLI	R-HSA-5656121	6.381738e-01	0.195
Defective GALNT12 causes CRCS1	R-HSA-5083636	6.381738e-01	0.195
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	6.381738e-01	0.195
Defective GALNT3 causes HFTC	R-HSA-5083625	6.381738e-01	0.195
Differentiation of T cells	R-HSA-9945266	6.381738e-01	0.195
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.381738e-01	0.195
Regulation of NF-kappa B signaling	R-HSA-9758274	6.381738e-01	0.195
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.381738e-01	0.195
Regulation of BACH1 activity	R-HSA-9708530	6.381738e-01	0.195
Activation of SMO	R-HSA-5635838	6.381738e-01	0.195
Prolonged ERK activation events	R-HSA-169893	6.381738e-01	0.195
DNA Double-Strand Break Repair	R-HSA-5693532	6.392545e-01	0.194
Protein localization	R-HSA-9609507	6.392545e-01	0.194
Glycosphingolipid transport	R-HSA-9845576	6.419789e-01	0.192
G1/S-Specific Transcription	R-HSA-69205	6.419789e-01	0.192
Dual incision in TC-NER	R-HSA-6782135	6.515871e-01	0.186
Translesion synthesis by POLK	R-HSA-5655862	6.561170e-01	0.183
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	6.561170e-01	0.183
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.561170e-01	0.183
TRAF3-dependent IRF activation pathway	R-HSA-918233	6.561170e-01	0.183
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	6.561170e-01	0.183
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.561170e-01	0.183
Fibronectin matrix formation	R-HSA-1566977	6.561170e-01	0.183
SHC1 events in ERBB4 signaling	R-HSA-1250347	6.561170e-01	0.183
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	6.561170e-01	0.183
Disorders of Developmental Biology	R-HSA-9675151	6.561170e-01	0.183
Galactose catabolism	R-HSA-70370	6.561170e-01	0.183
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	6.561170e-01	0.183
Transcriptional regulation of testis differentiation	R-HSA-9690406	6.561170e-01	0.183
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	6.619444e-01	0.179
Transcriptional Regulation by TP53	R-HSA-3700989	6.631461e-01	0.178
Parasitic Infection Pathways	R-HSA-9824443	6.659611e-01	0.177
Leishmania infection	R-HSA-9658195	6.659611e-01	0.177
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.663018e-01	0.176
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.663018e-01	0.176
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	6.663018e-01	0.176
Signaling by Hedgehog	R-HSA-5358351	6.720980e-01	0.173
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	6.731715e-01	0.172
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.731715e-01	0.172
GDP-fucose biosynthesis	R-HSA-6787639	6.731715e-01	0.172
Choline catabolism	R-HSA-6798163	6.731715e-01	0.172
Glycogen storage diseases	R-HSA-3229121	6.731715e-01	0.172
Specification of primordial germ cells	R-HSA-9827857	6.731715e-01	0.172
Uptake and function of anthrax toxins	R-HSA-5210891	6.731715e-01	0.172
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.731715e-01	0.172
Interferon gamma signaling	R-HSA-877300	6.763686e-01	0.170
RAS processing	R-HSA-9648002	6.779546e-01	0.169
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	6.779546e-01	0.169
Plasma lipoprotein clearance	R-HSA-8964043	6.779546e-01	0.169
MAP kinase activation	R-HSA-450294	6.806843e-01	0.167
Interleukin-2 family signaling	R-HSA-451927	6.892733e-01	0.162
Generation of second messenger molecules	R-HSA-202433	6.892733e-01	0.162
Glycogen metabolism	R-HSA-8982491	6.892733e-01	0.162
Mitochondrial tRNA aminoacylation	R-HSA-379726	6.892733e-01	0.162
Nuclear signaling by ERBB4	R-HSA-1251985	6.892733e-01	0.162
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	6.893812e-01	0.162
Regulation of TP53 Activity through Methylation	R-HSA-6804760	6.893812e-01	0.162
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	6.899727e-01	0.161
Heme signaling	R-HSA-9707616	6.899727e-01	0.161
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	6.904229e-01	0.161
Resolution of Abasic Sites (AP sites)	R-HSA-73933	7.002626e-01	0.155
Cellular response to chemical stress	R-HSA-9711123	7.027041e-01	0.153
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.047879e-01	0.152
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.047879e-01	0.152
Translesion Synthesis by POLH	R-HSA-110320	7.047879e-01	0.152
Crosslinking of collagen fibrils	R-HSA-2243919	7.047879e-01	0.152
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	7.047879e-01	0.152
E2F mediated regulation of DNA replication	R-HSA-113510	7.047879e-01	0.152
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.047879e-01	0.152
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	7.047879e-01	0.152
IKK complex recruitment mediated by RIP1	R-HSA-937041	7.047879e-01	0.152
Diseases of hemostasis	R-HSA-9671793	7.047879e-01	0.152
Rap1 signalling	R-HSA-392517	7.047879e-01	0.152
STING mediated induction of host immune responses	R-HSA-1834941	7.047879e-01	0.152
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	7.047879e-01	0.152
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.047879e-01	0.152
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	7.079371e-01	0.150
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	7.104775e-01	0.148
XBP1(S) activates chaperone genes	R-HSA-381038	7.104775e-01	0.148
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.194313e-01	0.143
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.194313e-01	0.143
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.194313e-01	0.143
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.194313e-01	0.143
Formation of definitive endoderm	R-HSA-9823730	7.194313e-01	0.143
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	7.194313e-01	0.143
Wax and plasmalogen biosynthesis	R-HSA-8848584	7.194313e-01	0.143
SLC transporter disorders	R-HSA-5619102	7.220523e-01	0.141
Antigen processing-Cross presentation	R-HSA-1236975	7.285721e-01	0.138
Stimuli-sensing channels	R-HSA-2672351	7.285721e-01	0.138
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.313034e-01	0.136
ER-Phagosome pathway	R-HSA-1236974	7.327558e-01	0.135
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	7.333491e-01	0.135
SHC-mediated cascade:FGFR3	R-HSA-5654704	7.333491e-01	0.135
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	7.333491e-01	0.135
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	7.333491e-01	0.135
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	7.333491e-01	0.135
Zygotic genome activation (ZGA)	R-HSA-9819196	7.333491e-01	0.135
Basigin interactions	R-HSA-210991	7.333491e-01	0.135
HDR through Homologous Recombination (HRR)	R-HSA-5685942	7.333694e-01	0.135
Proteasome assembly	R-HSA-9907900	7.410261e-01	0.130
Surfactant metabolism	R-HSA-5683826	7.410261e-01	0.130
Transcription of the HIV genome	R-HSA-167172	7.414490e-01	0.130
tRNA processing	R-HSA-72306	7.432045e-01	0.129
SHC-mediated cascade:FGFR4	R-HSA-5654719	7.465774e-01	0.127
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.465774e-01	0.127
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.465774e-01	0.127
Molybdenum cofactor biosynthesis	R-HSA-947581	7.465774e-01	0.127
Serine metabolism	R-HSA-977347	7.465774e-01	0.127
Potential therapeutics for SARS	R-HSA-9679191	7.488362e-01	0.126
Somitogenesis	R-HSA-9824272	7.504463e-01	0.125
IRE1alpha activates chaperones	R-HSA-381070	7.537217e-01	0.123
FCERI mediated MAPK activation	R-HSA-2871796	7.540409e-01	0.123
KEAP1-NFE2L2 pathway	R-HSA-9755511	7.541706e-01	0.123
Interleukin-17 signaling	R-HSA-448424	7.570230e-01	0.121
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	7.570230e-01	0.121
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.570230e-01	0.121
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.591502e-01	0.120
Notch-HLH transcription pathway	R-HSA-350054	7.591502e-01	0.120
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.591502e-01	0.120
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.591502e-01	0.120
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	7.591502e-01	0.120
LDL clearance	R-HSA-8964038	7.591502e-01	0.120
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	7.594234e-01	0.120
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.595700e-01	0.119
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.595700e-01	0.119
Diseases of DNA repair	R-HSA-9675135	7.595700e-01	0.119
Late SARS-CoV-2 Infection Events	R-HSA-9772573	7.604225e-01	0.119
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.710999e-01	0.113
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.710999e-01	0.113
Termination of O-glycan biosynthesis	R-HSA-977068	7.710999e-01	0.113
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.710999e-01	0.113
Carnitine shuttle	R-HSA-200425	7.710999e-01	0.113
Interleukin-20 family signaling	R-HSA-8854691	7.710999e-01	0.113
Interleukin receptor SHC signaling	R-HSA-912526	7.710999e-01	0.113
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.718311e-01	0.112
Intraflagellar transport	R-HSA-5620924	7.769533e-01	0.110
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.796759e-01	0.108
TRAF6 mediated NF-kB activation	R-HSA-933542	7.824575e-01	0.107
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	7.824575e-01	0.107
SHC-mediated cascade:FGFR1	R-HSA-5654688	7.824575e-01	0.107
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.824575e-01	0.107
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.824575e-01	0.107
Complex III assembly	R-HSA-9865881	7.824575e-01	0.107
Plasma lipoprotein assembly	R-HSA-8963898	7.824575e-01	0.107
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	7.824575e-01	0.107
Extracellular matrix organization	R-HSA-1474244	7.834544e-01	0.106
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	7.892405e-01	0.103
Protein ubiquitination	R-HSA-8852135	7.926504e-01	0.101
Signaling by FGFR2 in disease	R-HSA-5655253	7.932268e-01	0.101
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	7.932521e-01	0.101
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.932521e-01	0.101
TGFBR3 expression	R-HSA-9839394	7.932521e-01	0.101
Acyl chain remodelling of PS	R-HSA-1482801	7.932521e-01	0.101
Laminin interactions	R-HSA-3000157	7.932521e-01	0.101
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.932521e-01	0.101
Disorders of transmembrane transporters	R-HSA-5619115	7.957490e-01	0.099
Signaling by TGFB family members	R-HSA-9006936	7.985393e-01	0.098
Regulation of TP53 Activity	R-HSA-5633007	7.985393e-01	0.098
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.035118e-01	0.095
TRP channels	R-HSA-3295583	8.035118e-01	0.095
Suppression of phagosomal maturation	R-HSA-9637687	8.035118e-01	0.095
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	8.035118e-01	0.095
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	8.084423e-01	0.092
Neuronal System	R-HSA-112316	8.100742e-01	0.091
ABC transporter disorders	R-HSA-5619084	8.118632e-01	0.091
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.132629e-01	0.090
SHC-mediated cascade:FGFR2	R-HSA-5654699	8.132629e-01	0.090
ER Quality Control Compartment (ERQC)	R-HSA-901032	8.132629e-01	0.090
Maturation of hRSV A proteins	R-HSA-9828806	8.132629e-01	0.090
Signaling by FGFR3 in disease	R-HSA-5655332	8.132629e-01	0.090
Nuclear events mediated by NFE2L2	R-HSA-9759194	8.147937e-01	0.089
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.225307e-01	0.085
Insulin receptor recycling	R-HSA-77387	8.225307e-01	0.085
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.225307e-01	0.085
Formation of the cornified envelope	R-HSA-6809371	8.291050e-01	0.081
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.313390e-01	0.080
mRNA Capping	R-HSA-72086	8.313390e-01	0.080
Termination of translesion DNA synthesis	R-HSA-5656169	8.313390e-01	0.080
Regulation of gene expression in beta cells	R-HSA-210745	8.313390e-01	0.080
Platelet calcium homeostasis	R-HSA-418360	8.313390e-01	0.080
Downstream signaling of activated FGFR3	R-HSA-5654708	8.313390e-01	0.080
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	8.313390e-01	0.080
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.397107e-01	0.076
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.397107e-01	0.076
Downstream signaling of activated FGFR4	R-HSA-5654716	8.397107e-01	0.076
Neurotransmitter clearance	R-HSA-112311	8.397107e-01	0.076
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.397107e-01	0.076
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	8.405306e-01	0.075
Dectin-2 family	R-HSA-5621480	8.421951e-01	0.075
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	8.446540e-01	0.073
Budding and maturation of HIV virion	R-HSA-162588	8.476673e-01	0.072
Cargo concentration in the ER	R-HSA-5694530	8.476673e-01	0.072
Gastrulation	R-HSA-9758941	8.505122e-01	0.070
Protein-protein interactions at synapses	R-HSA-6794362	8.508957e-01	0.070
G alpha (q) signalling events	R-HSA-416476	8.531962e-01	0.069
Peroxisomal protein import	R-HSA-9033241	8.541169e-01	0.068
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.558547e-01	0.068
tRNA Aminoacylation	R-HSA-379724	8.597645e-01	0.066
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.597645e-01	0.066
Metabolism of polyamines	R-HSA-351202	8.597645e-01	0.066
Adaptive Immune System	R-HSA-1280218	8.614757e-01	0.065
Interleukin-1 family signaling	R-HSA-446652	8.616957e-01	0.065
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	8.624165e-01	0.064
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	8.624165e-01	0.064
G-protein beta:gamma signalling	R-HSA-397795	8.624165e-01	0.064
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	8.624165e-01	0.064
Formation of paraxial mesoderm	R-HSA-9793380	8.652115e-01	0.063
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	8.665370e-01	0.062
MyD88-independent TLR4 cascade	R-HSA-166166	8.665370e-01	0.062
Resolution of D-Loop Structures	R-HSA-5693537	8.692473e-01	0.061
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.704637e-01	0.060
PPARA activates gene expression	R-HSA-1989781	8.721792e-01	0.059
NOD1/2 Signaling Pathway	R-HSA-168638	8.757393e-01	0.058
Calnexin/calreticulin cycle	R-HSA-901042	8.757393e-01	0.058
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.757393e-01	0.058
Signal amplification	R-HSA-392518	8.757393e-01	0.058
eNOS activation	R-HSA-203615	8.757393e-01	0.058
Neurotransmitter release cycle	R-HSA-112310	8.785411e-01	0.056
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.787933e-01	0.056
Downstream signaling of activated FGFR2	R-HSA-5654696	8.819093e-01	0.055
Downstream signaling of activated FGFR1	R-HSA-5654687	8.819093e-01	0.055
PERK regulates gene expression	R-HSA-381042	8.819093e-01	0.055
Lysosome Vesicle Biogenesis	R-HSA-432720	8.877734e-01	0.052
FGFR2 mutant receptor activation	R-HSA-1839126	8.877734e-01	0.052
TP53 Regulates Metabolic Genes	R-HSA-5628897	8.892561e-01	0.051
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.905788e-01	0.050
TRAF6 mediated IRF7 activation	R-HSA-933541	8.933466e-01	0.049
Metabolism of folate and pterines	R-HSA-196757	8.933466e-01	0.049
Unfolded Protein Response (UPR)	R-HSA-381119	8.970941e-01	0.047
Regulated Necrosis	R-HSA-5218859	8.982112e-01	0.047
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.986433e-01	0.046
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.986433e-01	0.046
Peptide hormone metabolism	R-HSA-2980736	8.992932e-01	0.046
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.036773e-01	0.044
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.036773e-01	0.044
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.061571e-01	0.043
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.082822e-01	0.042
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.084616e-01	0.042
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.084616e-01	0.042
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.084616e-01	0.042
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.099091e-01	0.041
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	9.099091e-01	0.041
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.114248e-01	0.040
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.130085e-01	0.040
Maturation of spike protein	R-HSA-9694548	9.130085e-01	0.040
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.135201e-01	0.039
FCERI mediated NF-kB activation	R-HSA-2871837	9.138490e-01	0.039
MyD88 cascade initiated on plasma membrane	R-HSA-975871	9.146060e-01	0.039
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	9.146060e-01	0.039
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	9.146060e-01	0.039
Ca2+ pathway	R-HSA-4086398	9.169951e-01	0.038
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.173298e-01	0.037
HIV Transcription Initiation	R-HSA-167161	9.173298e-01	0.037
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.173298e-01	0.037
Scavenging by Class A Receptors	R-HSA-3000480	9.173298e-01	0.037
ABC-family proteins mediated transport	R-HSA-382556	9.205306e-01	0.036
Cytosolic tRNA aminoacylation	R-HSA-379716	9.214367e-01	0.036
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.214367e-01	0.036
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.214367e-01	0.036
Innate Immune System	R-HSA-168249	9.216334e-01	0.035
Neddylation	R-HSA-8951664	9.221089e-01	0.035
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	9.236422e-01	0.034
RNA Polymerase II Promoter Escape	R-HSA-73776	9.253398e-01	0.034
Signaling by NOTCH1	R-HSA-1980143	9.266486e-01	0.033
SLC-mediated transport of organic anions	R-HSA-9955298	9.324848e-01	0.030
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.325746e-01	0.030
Fanconi Anemia Pathway	R-HSA-6783310	9.325746e-01	0.030
Regulation of pyruvate metabolism	R-HSA-9861718	9.359250e-01	0.029
Signaling by TGFBR3	R-HSA-9839373	9.359250e-01	0.029
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.378797e-01	0.028
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.391091e-01	0.027
Synthesis of PC	R-HSA-1483191	9.391091e-01	0.027
GPER1 signaling	R-HSA-9634597	9.421352e-01	0.026
Degradation of the extracellular matrix	R-HSA-1474228	9.423534e-01	0.026
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.428084e-01	0.026
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.448896e-01	0.025
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.450110e-01	0.025
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	9.450110e-01	0.025
Chemokine receptors bind chemokines	R-HSA-380108	9.450110e-01	0.025
Cytoprotection by HMOX1	R-HSA-9707564	9.452112e-01	0.024
Azathioprine ADME	R-HSA-9748787	9.477441e-01	0.023
Complex IV assembly	R-HSA-9864848	9.503415e-01	0.022
Branched-chain amino acid catabolism	R-HSA-70895	9.503415e-01	0.022
Integration of energy metabolism	R-HSA-163685	9.513583e-01	0.022
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.525303e-01	0.021
Amino acids regulate mTORC1	R-HSA-9639288	9.551558e-01	0.020
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	9.575991e-01	0.019
Role of phospholipids in phagocytosis	R-HSA-2029485	9.591728e-01	0.018
Synthesis of PA	R-HSA-1483166	9.634309e-01	0.016
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	9.634309e-01	0.016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	9.649358e-01	0.016
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	9.649358e-01	0.016
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.652493e-01	0.015
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.652493e-01	0.015
Regulation of beta-cell development	R-HSA-186712	9.669775e-01	0.015
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.670867e-01	0.015
FCGR activation	R-HSA-2029481	9.670867e-01	0.015
Post-translational protein modification	R-HSA-597592	9.678471e-01	0.014
RAB geranylgeranylation	R-HSA-8873719	9.686198e-01	0.014
Signaling by NOTCH1 in Cancer	R-HSA-2644603	9.686198e-01	0.014
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	9.686198e-01	0.014
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	9.686198e-01	0.014
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	9.686198e-01	0.014
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	9.686198e-01	0.014
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	9.687456e-01	0.014
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	9.687456e-01	0.014
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.698145e-01	0.013
Complex I biogenesis	R-HSA-6799198	9.730732e-01	0.012
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.730732e-01	0.012
Regulation of insulin secretion	R-HSA-422356	9.745890e-01	0.011
Cell surface interactions at the vascular wall	R-HSA-202733	9.757601e-01	0.011
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.768952e-01	0.010
Nicotinate metabolism	R-HSA-196807	9.780447e-01	0.010
PI Metabolism	R-HSA-1483255	9.786418e-01	0.009
O-linked glycosylation of mucins	R-HSA-913709	9.791372e-01	0.009
Asparagine N-linked glycosylation	R-HSA-446203	9.793057e-01	0.009
Toll-like Receptor Cascades	R-HSA-168898	9.816698e-01	0.008
ECM proteoglycans	R-HSA-3000178	9.820993e-01	0.008
Metabolism of cofactors	R-HSA-8978934	9.820993e-01	0.008
Diseases of carbohydrate metabolism	R-HSA-5663084	9.838368e-01	0.007
ROS and RNS production in phagocytes	R-HSA-1222556	9.846414e-01	0.007
Citric acid cycle (TCA cycle)	R-HSA-71403	9.854059e-01	0.006
Iron uptake and transport	R-HSA-917937	9.854059e-01	0.006
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.868228e-01	0.006
Nuclear Receptor transcription pathway	R-HSA-383280	9.874788e-01	0.005
Integrin cell surface interactions	R-HSA-216083	9.874788e-01	0.005
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.881023e-01	0.005
Keratinization	R-HSA-6805567	9.894970e-01	0.005
Visual phototransduction	R-HSA-2187338	9.900681e-01	0.004
Diseases of glycosylation	R-HSA-3781865	9.920615e-01	0.003
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	9.920937e-01	0.003
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.924390e-01	0.003
Pyruvate metabolism	R-HSA-70268	9.924876e-01	0.003
Class B/2 (Secretin family receptors)	R-HSA-373080	9.935555e-01	0.003
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.938221e-01	0.003
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.955543e-01	0.002
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.955822e-01	0.002
Mitochondrial translation elongation	R-HSA-5389840	9.957188e-01	0.002
Potassium Channels	R-HSA-1296071	9.957188e-01	0.002
Post-translational protein phosphorylation	R-HSA-8957275	9.961350e-01	0.002
Mitochondrial translation initiation	R-HSA-5368286	9.961350e-01	0.002
Glycerophospholipid biosynthesis	R-HSA-1483206	9.961845e-01	0.002
Synthesis of bile acids and bile salts	R-HSA-192105	9.963278e-01	0.002
G alpha (s) signalling events	R-HSA-418555	9.964529e-01	0.002
GPCR downstream signalling	R-HSA-388396	9.968399e-01	0.001
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.970073e-01	0.001
Bacterial Infection Pathways	R-HSA-9824439	9.972875e-01	0.001
Platelet homeostasis	R-HSA-418346	9.975612e-01	0.001
Mitochondrial translation termination	R-HSA-5419276	9.979083e-01	0.001
Bile acid and bile salt metabolism	R-HSA-194068	9.980126e-01	0.001
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.984615e-01	0.001
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.986112e-01	0.001
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.986890e-01	0.001
Phospholipid metabolism	R-HSA-1483257	9.987208e-01	0.001
Signaling by GPCR	R-HSA-372790	9.992156e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.993950e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.994043e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.994043e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.994478e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.994478e-01	0.000
Respiratory electron transport	R-HSA-611105	9.995283e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.996143e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.996336e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.996757e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.997199e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.997749e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.998120e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.998400e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999084e-01	0.000
Transport of small molecules	R-HSA-382551	9.999399e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999712e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999765e-01	0.000
Diseases of metabolism	R-HSA-5668914	9.999931e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999942e-01	0.000
Drug ADME	R-HSA-9748784	9.999949e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999996e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999998e-01	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000