PRKD3

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A4FU28 S140 Sugiyama CTAGE9 AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
A5A3E0 S1065 Sugiyama POTEF A26C1B ILASLSTFQQMWISKQEyDEsGPsIVHRKCL__________
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00116 S632 Sugiyama AGPS AAG5 SLSHHHGVGKLRKQWLKESIsDVGFGMLKSVKEyVDPNNIF
O00299 S211 Sugiyama CLIC1 G6 NCC27 CKKYRGFTIPEAFRGVHRYLsNAyAREEFAstCPDDEEIEL
O00488 S40 Sugiyama ZNF593 ZT86 KAKRRRPDLDEIHRELRPQGsARPQPDPNAEFDPDLPGGGL
O00488 S93 Sugiyama ZNF593 ZT86 STNLKTHFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVP
O14646 S1017 Sugiyama CHD1 KRAETHENEPGPLtVGDELLsQFKVANFsNMDEDDIELEPE
O14646 T1010 Sugiyama CHD1 MDIDEILKRAETHENEPGPLtVGDELLsQFKVANFsNMDED
O14745 S291 Sugiyama NHERF1 NHERF SLC9A3R1 EALAEAALEsPRPALVRsAssDtsEELNsQDsPPKQDSTAP
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974 S995 Sugiyama PPP1R12A MBS MYPT1 ADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLK
O15067 S215 Sugiyama PFAS KIAA0361 LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15143 S310 Sugiyama ARPC1B ARC41 QSSQRGLTARERFQNLDKKAssEGGtAAGAGLDsLHKNsVs
O15355 S527 Sugiyama PPM1G PPM1C PRNTAELQPEsGKRKLEEVLstEGAEENGNsDKKKKAKRD_
O15460 T532 Sugiyama P4HA2 UNQ290/PRO330 WVSNKWFHERGQEFLRPCGstEVD_________________
O43175 S14 Sugiyama PHGDH PGDH3 _______MAFANLRKVLIsDsLDPCCRKILQDGGLQVVEKQ
O43175 S251 Sugiyama PHGDH PGDH3 VVNCARGGIVDEGALLRALQsGQCAGAALDVFTEEPPRDRA
O43324 S100 Sugiyama EEF1E1 AIMP3 P18 TQVDGHSSKNDIHTLLKDLNsyLEDKVYLTGYNFTLADILL
O43390 S426 Sugiyama HNRNPR HNRPR IVLAKPPDKKRKERQAARQAsRstAyEDyyyHPPPRMPPPI
O43390 T429 Sugiyama HNRNPR HNRPR AKPPDKKRKERQAARQAsRstAyEDyyyHPPPRMPPPIRGR
O43615 S180 Sugiyama TIMM44 MIMT44 TIM44 AESVSKGGEKLGRTAAFRALsQGVEsVKKEIDDsVLGQtGP
O43815 S229 Sugiyama STRN TEAEVKETAMIAKSELtDsAsVLDNFKFLEsAAADFsDEDE
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852 S69 Sugiyama CALU HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O43852 Y263 Sugiyama CALU KNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNKDG
O60271 S183 Sugiyama SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 HTEMIHNYMEHLERTKLHQLsGsDQLEstAHsRIRKERPIs
O60343 S485 Sugiyama TBC1D4 AS160 KIAA0603 CERIEGLYPPRAKLVIQRHLssLtDNEQADIFERVQKMKPV
O60610 S542 Sugiyama DIAPH1 DIAP1 ALHSEKQQIATEKQDLEAEVsQLtGEVAKLTKELEDAKKEM
O60664 S148 Sugiyama PLIN3 M6PRBP1 TIP47 KVsGAQEMVssAKDTVAtQLsEAVDATRGAVQSGVDKTKsV
O60664 S175 Sugiyama PLIN3 M6PRBP1 TIP47 RGAVQSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGK
O60749 S226 Sugiyama SNX2 TRG9 PPAPEKSIVGMTKVKVGKEDssSTEFVEKRRAALERYLQRT
O60749 S227 Sugiyama SNX2 TRG9 PAPEKSIVGMTKVKVGKEDssSTEFVEKRRAALERYLQRTV
O60749 S365 Sugiyama SNX2 TRG9 AKSAAMLGNsEDHTALSRALsQLAEVEEKIDQLHQEQAFAD
O75340 S120 Sugiyama PDCD6 ALG2 RTYDRDNsGMIDKNELKQALsGFGYRLSDQFHDILIRKFDR
O75348 S65 Sugiyama ATP6V1G1 ATP6G ATP6G1 ATP6J EQyRLQREKEFKAKEAAALGsRGsCstEVEKETQEKMTILQ
O75348 S68 Sugiyama ATP6V1G1 ATP6G ATP6G1 ATP6J RLQREKEFKAKEAAALGsRGsCstEVEKETQEKMTILQtyF
O75369 S2532 Sugiyama FLNB FLN1L FLN3 TABP TAP ASKVTSKGAGLSKAFVGQKssFLVDCSKAGSNMLLIGVHGP
O75534 S584 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR YSLSKGKGNKVSAEKVNKtHsVNGItEEADPTIysGKVIRP
O75937 S81 Sugiyama DNAJC8 SPF31 HSPC315 HSPC331 VLQIDPEVTDEEIKKRFRQLsILVHPDKNQDDADRAQKAFE
O76003 S120 Sugiyama GLRX3 PICOT TXNL2 HUSSY-22 LDGAHAPELTKKVQRHAssGsFLPSANEHLKEDLNLRLKKL
O76021 S314 Sugiyama RSL1D1 CATX11 CSIG PBK1 L12 RNFEKQKERKKKRQQARKtAsVLsKDDVAPEsGDtTVKKPE
O94776 Y437 Sugiyama MTA2 MTA1L1 PID tTEPHSRGHLsRPEAQsLsPyttsANRAKLLAKNRQtFLLQ
O94804 S875 Sugiyama STK10 LOK RLQQQQKHENQMRDMLAQCEsNMSELQQLQNEKCHLLVEHE
O94806 S27 Sugiyama PRKD3 EPK2 PRKCN PPSAQKSVLPtAIPAVLPAAsPCssPKTGLsARLsNGsFSA
O94806 S364 Sugiyama PRKD3 EPK2 PRKCN IDNNDINSDSSRGLDDtEEPsPPEDKMFFLDPsDLDVERDE
O94806 S376 Sugiyama PRKD3 EPK2 PRKCN GLDDtEEPsPPEDKMFFLDPsDLDVERDEEAVKtIsPstsN
O94806 S391 Sugiyama PRKD3 EPK2 PRKCN FFLDPsDLDVERDEEAVKtIsPstsNNIPLMRVVQSIKHTK
O94806 S393 Sugiyama PRKD3 EPK2 PRKCN LDPsDLDVERDEEAVKtIsPstsNNIPLMRVVQSIKHTKRK
O94806 S395 Sugiyama PRKD3 EPK2 PRKCN PsDLDVERDEEAVKtIsPstsNNIPLMRVVQSIKHTKRKSS
O94806 S41 Sugiyama PRKD3 EPK2 PRKCN AVLPAAsPCssPKTGLsARLsNGsFSAPsLTNSRGSVHTVS
O94806 S44 Sugiyama PRKD3 EPK2 PRKCN PAAsPCssPKTGLsARLsNGsFSAPsLTNSRGSVHTVSFLL
O94806 S452 Sugiyama PRKD3 EPK2 PRKCN LRKRHYWRLDsKCLTLFQNEsGSKYYKEIPLSEILRISSPR
O94806 S49 Sugiyama PRKD3 EPK2 PRKCN CssPKTGLsARLsNGsFSAPsLTNSRGSVHTVSFLLQIGLT
O94806 S539 Sugiyama PRKD3 EPK2 PRKCN VAQSWEKAIRQALMPVtPQAsVCtsPGQGKDHKDLSTSISV
O94806 S543 Sugiyama PRKD3 EPK2 PRKCN WEKAIRQALMPVtPQAsVCtsPGQGKDHKDLSTSISVSNCQ
O94806 S735 EPSD|Sugiyama PRKD3 EPK2 PRKCN QVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRSKGYNR
O94806 T17 Sugiyama PRKD3 EPK2 PRKCN ____MSANNsPPSAQKSVLPtAIPAVLPAAsPCssPKTGLs
O94806 T360 Sugiyama PRKD3 EPK2 PRKCN IPMDIDNNDINSDSSRGLDDtEEPsPPEDKMFFLDPsDLDV
O94806 T535 Sugiyama PRKD3 EPK2 PRKCN VGLDVAQSWEKAIRQALMPVtPQAsVCtsPGQGKDHKDLST
O94806 T542 Sugiyama PRKD3 EPK2 PRKCN SWEKAIRQALMPVtPQAsVCtsPGQGKDHKDLSTSISVSNC
O94806 T739 Sugiyama PRKD3 EPK2 PRKCN CDFGFARIIGEKsFRRsVVGtPAyLAPEVLRSKGYNRSLDM
O94806 Y742 Sugiyama PRKD3 EPK2 PRKCN GFARIIGEKsFRRsVVGtPAyLAPEVLRSKGYNRSLDMWSV
O95071 S115 Sugiyama UBR5 EDD EDD1 HYD KIAA0896 NSGAGRTSRPGRTSDsPWFLsGSEtLGRLAGNTLGSRWSsG
O95602 S240 Sugiyama POLR1A NSKLTITFPAMVHRTAGQKDsEPLGIEEAQIGKRGYLTPTS
O96013 S474 SIGNOR PAK4 KIAA1142 VKLSDFGFCAQVSKEVPRRKsLVGtPYWMAPELISRLPYGP
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00558 S415 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GGGAsLELLEGKVLPGVDALsNI__________________
P04075 S176 Sugiyama ALDOA ALDA EHtPsALAIMENANVLARyAsICQQNGIVPIVEPEILPDGD
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04792 S15 Sugiyama HSPB1 HSP27 HSP28 ______MTERRVPFsLLRGPsWDPFRDWyPHsRLFDQAFGL
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05023 S519 Sugiyama ATP1A1 sEPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQ
P05023 S520 Sugiyama ATP1A1 EPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQN
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05997 S1277 Sugiyama COL5A2 APDDKNKTDPGVHATLKSLSsQIETMRSPDGSKKHPARTCD
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07237 S427 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07339 S37 Sugiyama CTSD CPSD PASALVRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQ
P07711 S329 Sugiyama CTSL CTSL1 GGyVKMAKDRRNHCGIAsAAsyPtV________________
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 S623 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tyGWTANMERIMKAQALRDNstMGyMAAKKHLEINPDHsII
P08238 S206 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEDQtEyLEERRVKEVVKKHsQFIGyPItLyLEKEREKEIs
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08758 T10 Sugiyama ANXA5 ANX5 ENX2 PP4 ___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P09001 Y265 Sugiyama MRPL3 MRL3 RPML3 TGDIGRVWPGTKMPGKMGNIyRTEYGLKVWRINTKHNIIYV
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09972 S176 Sugiyama ALDOC ALDC ERTPSALAILENANVLARyAsICQQNGIVPIVEPEILPDGD
P0CG38 S1065 Sugiyama POTEI ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG39 S1028 Sugiyama POTEJ ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG41 S140 Sugiyama CTAGE8 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P10412 S89 Sugiyama H1-4 H1F4 HIST1H1E AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P10412 T92 Sugiyama H1-4 H1F4 HIST1H1E DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P10809 S398 Sugiyama HSPD1 HSP60 LDVttsEyEKEKLNERLAKLsDGVAVLKVGGtsDVEVNEKK
P11142 S541 Sugiyama HSPA8 HSC70 HSP73 HSPA10 EAEKYKAEDEKQRDKVssKNsLEsyAFNMKATVEDEKLQGK
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11388 S1374 Sugiyama TOP2A TOP2 sPPKtKTsPKLsNKELKPQKsVVsDLEADDVKGsVPLsssP
P11532 S3623 Sugiyama DMD EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13674 S366 Sugiyama P4HA1 P4HA DAEIEIVKDLAKPRLRRAtIsNPITGDLETVHYRISKsAWL
P13674 T140 Sugiyama P4HA1 P4HA YFPNDEDQVGAAKALLRLQDtyNLDTDtIsKGNLPGVKHKS
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14618 S97 Sugiyama PKM OIP3 PK2 PK3 PKM2 sHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGP
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15374 S128 Sugiyama UCHL3 KDKMHFESGSTLKKFLEEsVsMsPEERARyLENyDAIRVtH
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15880 T278 Sugiyama RPS2 RPS4 EtVFtKsPyQEFtDHLVKtHtRVsVQRtQAPAVATt_____
P15880 T285 Sugiyama RPS2 RPS4 PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P15924 S1658 Sugiyama DSP DVLDGHLREKQRTQEELRRLssEVEALRRQLLQEQESVKQA
P16401 S92 Sugiyama H1-5 H1F5 HIST1H1B GGYDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16401 T95 Sugiyama H1-5 H1F5 HIST1H1B DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16402 S90 Sugiyama H1-3 H1F3 HIST1H1D AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16402 T93 Sugiyama H1-3 H1F3 HIST1H1D DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16403 S89 Sugiyama H1-2 H1F2 HIST1H1C AGyDVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNK
P16403 T92 Sugiyama H1-2 H1F2 HIST1H1C DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19174 S1233 Sugiyama PLCG1 PLC1 PAKENGDLsPFsGtsLRERGsDASGQLFHGRAREGsFEsRy
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 S580 Sugiyama NCL PRGsPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARI
P22059 S240 Sugiyama OSBP OSBP1 DLSTCNDLIAKHGTALQRsLsELEsLKLPAESNEKIKQVNE
P22090 S204 Sugiyama RPS4Y1 RPS4Y PRO2646 IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22626 S102 Sugiyama HNRNPA2B1 HNRPA2B1 RPHsIDGRVVEPKRAVAREEsGKPGAHVtVKKLFVGGIKED
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S225 Sugiyama HNRNPA2B1 HNRPA2B1 GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P23528 S41 Sugiyama CFL1 CFL RKsstPEEVKKRKKAVLFCLsEDKKNIILEEGKEILVGDVG
P23921 S780 Sugiyama RRM1 RR1 KEKVSKEEEEKERNtAAMVCsLENRDECLMCGS________
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25205 S447 Sugiyama MCM3 EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25705 S198 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM GIIPRIsVREPMQTGIKAVDsLVPIGRGQRELIIGDRQTGK
P26038 S527 Sugiyama MSN ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 S97 Sugiyama RPL13 BBC1 OK/SW-cl.46 sLEELRVAGIHKKVARTIGIsVDPRRRNKstEsLQANVQRL
P26641 S25 Sugiyama EEF1G EF1G PRO1608 TLyTyPENWRAFKALIAAQYsGAQVRVLsAPPHFHFGQtNR
P27348 S63 Sugiyama YWHAQ LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P29401 S305 Sugiyama TKT LAtPPQEDAPsVDIANIRMPsLPsyKVGDKIATRKAYGQAL
P29692 S64 Sugiyama EEF1D EF1D sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P29692 S70 Sugiyama EEF1D EF1D IARARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVE
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30533 S135 Sugiyama LRPAP1 A2MRAP LNVILAKYGLDGKKDARQVtsNsLsGtQEDGLDDPRLEKLW
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30622 S1204 Sugiyama CLIP1 CYLN1 RSN EELGRSRDEVTSHQKLEEERsVLNNQLLEMKKRESKFIKDA
P31943 S269 Sugiyama HNRNPH1 HNRPH HNRPH1 YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQsttGH
P31946 S65 Sugiyama YWHAB LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR
P32119 S112 Sugiyama PRDX2 NKEFB TDPX1 KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P33527 S915 Sugiyama ABCC1 MRP MRP1 QMENGMLVTDsAGKQLQRQLsssssysGDISRHHNstAELQ
P35241 S532 Sugiyama RDX EERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHA
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35613 S277 Sugiyama BSG UNQ6505/PRO21383 KITDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPG
P35613 S279 Sugiyama BSG UNQ6505/PRO21383 TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P36578 S63 Sugiyama RPL4 RPL1 NLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGG
P36915 S68 Sugiyama GNL1 HSR1 tDtsDGEsVTHHIRRLNQQPsQGLGPRGYDPNRYRLHFERD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P40337 S68 Sugiyama VHL LGAEEEMEAGRPRPVLRSVNsREPsQVIFCNRsPRVVLPVW
P40818 T723 Sugiyama USP8 KIAA0055 UBPY PAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPTVNRE
P41236 T22 Sugiyama PPP1R2 IPP2 AASTAsHRPIKGILKNKtsttssMVAsAEQPRGNVDEELSK
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490 S472 Sugiyama NAMPT PBEF PBEF1 EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46060 S24 Sugiyama RANGAP1 KIAA1835 SD EDIAKLAETLAKTQVAGGQLsFKGKSLKLNTAEDAKDVIKE
P46060 S454 Sugiyama RANGAP1 KIAA1835 SD VstFLAFPsPEKLLRLGPKssVLIAQQTDTSDPEKVVSAFL
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46778 T29 Sugiyama RPL21 RGTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQ
P46779 S115 Sugiyama RPL28 HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P46779 S91 Sugiyama RPL28 RKPAtsyVRttINKNARAtLsSIRHMIRKNKYRPDLRMAAI
P46782 S75 Sugiyama RPS5 RYAAKRFRKAQCPIVERLtNsMMMHGRNNGKKLMTVRIVKH
P46940 S343 Sugiyama IQGAP1 KIAA0051 ALFRALQsPALGLRGLQQQNsDWYLKQLLSDKQQKRQsGQT
P47712 S178 Sugiyama PLA2G4A CPLA2 PLA2G4 RQQRKEHIRESMKKLLGPKNsEGLHSARDVPVVAILGSGGG
P49588 S775 Sugiyama AARS1 AARS VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P49840 S21 iPTMNet GSK3A MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs
P51532 S1380 Sugiyama SMARCA4 BAF190A BRG1 SNF2B SNF2L4 EEEEEKMFGRGSRHRKEVDYsDsLTEKQWLKAIEEGtLEEI
P51532 S1382 Sugiyama SMARCA4 BAF190A BRG1 SNF2B SNF2L4 EEEKMFGRGSRHRKEVDYsDsLTEKQWLKAIEEGtLEEIEE
P51991 S116 Sugiyama HNRNPA3 HNRPA3 RPHKVDGRVVEPKRAVsREDsVKPGAHLtVKKIFVGGIKED
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52298 Y14 Sugiyama NCBP2 CBP20 PIG55 _______MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQEK
P52907 S106 Sugiyama CAPZA1 RFLDPRNKISFKFDHLRKEAsDPQPEEADGGLKsWREsCDs
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396 S478 Sugiyama ACLY EsRADEVAPAKKAKPAMPQDsVPsPRSLQGKSTTLFSRHTK
P53621 S266 Sugiyama COPA RGHyNNVSCAVFHPRQELILsNsEDKSIRVWDMSKRTGVQT
P53621 S268 Sugiyama COPA HyNNVSCAVFHPRQELILsNsEDKSIRVWDMSKRTGVQTFR
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999 S12 Sugiyama SUB1 PC4 RPO2TC1 _________MPKSKELVsssssGsDsDsEVDKKLKRKKQVA
P55036 S266 Sugiyama PSMD4 MCB1 AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55735 S184 Sugiyama SEC13 D3S1231E SEC13A SEC13L1 SEC13R PGsLIDHPSGQKPNYIKRFAsGGCDNLIKLWKEEEDGQWKE
P55795 S269 Sugiyama HNRNPH2 FTP3 HNRPH2 YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQstTGH
P57772 S28 Sugiyama EEFSEC SELB VNVGVLGHIDSGKTALARALsTTASTAAFDKQPQSRERGIT
P60468 S49 Sugiyama SEC61B STVRQRKNASCGTRSAGRtTsAGTGGMWRFYTEDSPGLKVG
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S365 Sugiyama ACTB ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P60900 S175 Sugiyama PSMA6 PROS27 DPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTV
P61221 Y594 Sugiyama ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61247 S203 Sugiyama RPS3A FTE1 MFTL EVVNKLIPDsIGKDIEKACQsIyPLHDVFVRKVKMLKKPKF
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 S238 Sugiyama RPS3A FTE1 MFTL LKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyEP
P61254 S9 Sugiyama RPL26 ____________MKFNPFVtsDRsKNRKRHFNAPsHIRRKI
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61313 S118 Sugiyama RPL15 EC45 TCBAP0781 LQsVAEERAGRHCGALRVLNsyWVGEDSTyKFFEVILIDPF
P61313 S97 Sugiyama RPL15 EC45 TCBAP0781 KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S64 Sugiyama YWHAG LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263 S70 Sugiyama RPS14 PRO2640 KETICRVTGGMKVKADRDEssPyAAMLAAQDVAQRCKELGI
P62266 S45 Sugiyama RPS23 KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 S67 Sugiyama RPS11 PKEAIEGtyIDKKCPFTGNVsIRGRILsGVVTKMKMQRTIV
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62701 S204 Sugiyama RPS4X CCG2 RPS4 SCAR tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62826 T32 Sugiyama RAN ARA24 OK/SW-cl.81 KLVLVGDGGtGKttFVKRHLtGEFEKKyVATLGVEVHPLVF
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62937 S51 Sugiyama PPIA CYPA KtAENFRALSTGEKGFGYKGsCFHRIIPGFMCQGGDFtRHN
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S365 Sugiyama ACTG1 ACTG ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P78345 S253 Sugiyama RPP38 DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P78371 S470 Sugiyama CCT2 99D8.1 CCTB IADNAGYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAI
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q02539 S92 Sugiyama H1-1 H1F1 HIST1H1A AGyDVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNK
Q02539 T95 Sugiyama H1-1 H1F1 HIST1H1A DVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNKKAS
Q02880 S1522 Sugiyama TOP2B DTVPKPKRAPKQKKVVEAVNsDsDsEFGIPKKTTtPKGKGR
Q04917 S64 Sugiyama YWHAH YWHA1 LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA
Q05397 S677 Sugiyama PTK2 FAK FAK1 KCWAYDPSRRPRFTELKAQLsTILEEEKAQQEERMRMEsRR
Q07157 S585 Sugiyama TJP1 ZO1 NHKEVERGIIPNKNRAEQLAsVQytLPKTAGGDRADFWRFR
Q07666 S35 Sugiyama KHDRBS1 SAM68 sGRsGsMDPsGAHPsVRQtPsRQPPLPHRSRGGGGGSRGGA
Q08211 S1026 Sugiyama DHX9 DDX9 LKP NDH2 HKEKRKILTTEGRNALIHKssVNCPFssQDMKYPSPFFVFG
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q12906 S19 Sugiyama ILF3 DRBF MPHOSPH4 NF90 __MRPMRIFVNDDRHVMAKHssVyPTQEELEAVQNMVsHtE
Q13085 S1766 Sugiyama ACACA ACAC ACC1 ACCA KGYRYLYLTPQDYKRVsALNsVHCEHVEDEGESRYKITDII
Q13263 S471 Sugiyama TRIM28 KAP1 RNF96 TIF1B FGsGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLE
Q13263 S473 Sugiyama TRIM28 KAP1 RNF96 TIF1B sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13573 S234 Sugiyama SNW1 SKIIP SKIP INKKIPRGPPsPPAPVMHsPsRKMTVKEQQEWKIPPCISNW
Q13596 S229 Sugiyama SNX1 PPPPEKSLIGMTKVKVGKEDsssAEFLEKRRAALERYLQRI
Q13596 S231 Sugiyama SNX1 PPEKSLIGMTKVKVGKEDsssAEFLEKRRAALERYLQRIVN
Q13596 S368 Sugiyama SNX1 AKSLAMLGSSEDNTALSRALsQLAEVEEKIEQLHQEQANND
Q13625 T739 Sugiyama TP53BP2 ASPP2 BBP EALRKKLSNAPRPLKKRssItEPEGPNGPNIQKLLYQRTTI
Q13769 S314 Sugiyama THOC5 C22orf19 KIAA0983 VDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQLD
Q14126 S551 Sugiyama DSG2 CDHF5 FSVIDKPPGMAEKWKIARQEstsVLLQQSEKKLGRSEIQFL
Q14152 S1028 Sugiyama EIF3A EIF3S10 KIAA0139 NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152 S1257 Sugiyama EIF3A EIF3S10 KIAA0139 DRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRER
Q14152 S1258 Sugiyama EIF3A EIF3S10 KIAA0139 RFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRERD
Q14152 S492 Sugiyama EIF3A EIF3S10 KIAA0139 VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14160 S493 Sugiyama SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL RAtPHPSELKVMKRSIEGRRsEACPCQPDsGsPLPAEEEKR
Q14204 S2384 Sugiyama DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 FSEDVLSTDMIFNNFLARLRsIPLDEGEDEAQRRRKGKEDE
Q14247 S298 PSP CTTN EMS1 ERQDsAAVGFDyKEKLAKHEsQQDySKGFGGKyGVQKDRMD
Q14257 S37 Sugiyama RCN2 ERC55 AAAAGAGKAEELHyPLGERRsDyDREALLGVQEDVDEyVKL
Q14320 S50 Sugiyama FAM50A DXS9928E HXC26 XAP5 QMKQRIAEENIMKSNIDKKFsAHyDAVEAELKsstVGLVtL
Q14432 T311 Sugiyama PDE3A RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14966 S1228 Sugiyama ZNF638 NP220 ZFML DLEKKGAEIINPKTALLPSDsVFAEERNLKGILEEsPsEAE
Q14978 S456 Sugiyama NOLC1 KIAA0035 NS5ATP13 EKTKKMVATTKPKATAKAALsLPAKQAPQGSRDSSSDSDSS
Q15021 S1333 Sugiyama NCAPD2 CAPD2 CNAP1 KIAA0159 APsAKKPSTGSRyQPLAstAsDNDFVtPEPRRTTRRHPNTQ
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15139 S397 Sugiyama PRKD1 PKD PKD1 PRKCM NDSGEMQDPDPDHEDANRtIsPstsNNIPLMRVVQsVKHTK
Q15139 S399 Sugiyama PRKD1 PKD PKD1 PRKCM SGEMQDPDPDHEDANRtIsPstsNNIPLMRVVQsVKHTKRK
Q15139 S401 Sugiyama PRKD1 PKD PKD1 PRKCM EMQDPDPDHEDANRtIsPstsNNIPLMRVVQsVKHTKRKSs
Q15139 S738 EPSD|PSP PRKD1 PKD PKD1 PRKCM DPFPQVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNK
Q15139 S742 EPSD|PSP|Sugiyama PRKD1 PKD PKD1 PRKCM QVKLCDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNKGYNR
Q15139 T746 Sugiyama PRKD1 PKD PKD1 PRKCM CDFGFARIIGEKsFRRsVVGtPAyLAPEVLRNKGYNRSLDM
Q15139 Y749 Sugiyama PRKD1 PKD PKD1 PRKCM GFARIIGEKsFRRsVVGtPAyLAPEVLRNKGYNRSLDMWSV
Q15172 S472 Sugiyama PPP2R5A EELWKKLEELKLKKALEKQNsAyNMHSILSNTSAE______
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q15545 S171 Sugiyama TAF7 TAF2F TAFII55 TAKKKYIEsPDVEKEVKRLLstDAEAVSTRWEIIAEDETKE
Q15785 S93 Sugiyama TOMM34 URCC3 DCTSALALVPFSIKPLLRRAsAyEALEKYPMAYVDYKTVLQ
Q16204 S323 Sugiyama CCDC6 D10S170 TST1 RLQRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQ
Q16204 S325 Sugiyama CCDC6 D10S170 TST1 QRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQGL
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16576 S163 Sugiyama RBBP7 RBAP46 tPssDVLVFDyTKHPAKPDPsGECNPDLRLRGHQKEGYGLS
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3MII6 S506 Sugiyama TBC1D25 OATL1 DHLATASQGPGGGGRLLRQAsLDGLQQLRDNMGSRRDPLVQ
Q53EL6 S82 Sugiyama PDCD4 H731 RLRKNssRDsGRGDsVsDsGsDALRSGLtVPtsPKGRLLDR
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF7 S185 Sugiyama HSP90AB3P HSP90BC KEDQtEyLEERRVKEVVKKHsQFIGyPItLyLEKEQDKEIs
Q5RKV6 S14 Sugiyama EXOSC6 MTR3 _______MPGDHRRIRGPEEsQPPQLyAADEEEAPGTRDPT
Q5T035 S66 Sugiyama FAM120A2P C9orf129 LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI
Q5VT52 S1070 Sugiyama RPRD2 KIAA0460 HSPC099 TATDQQQQEEHYRIETRVsssCLDLPDSTEEKGAPIETLGy
Q6DD87 S104 Sugiyama ZNF787 HQRTHtGERPNACADCGKTFsQSSHLVQHRRIHtGEKPYAC
Q6FI81 T250 Sugiyama CIAPIN1 CUA001 PRO0915 ASLRAASCGEGKKRKACKNCtCGLAEELEKEKSREQMSSQP
Q6S8J3 S1065 Sugiyama POTEE A26C1A POTE2 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6UX04 S203 Sugiyama CWC27 SDCCAG10 UNQ438/PRO871 KKEKPEEEVKKLKPKGTKNFsLLsFGEEAEEEEEEVNRVSQ
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q86UF2 S140 Sugiyama CTAGE6 CTAGE6P AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86UP2 S1180 Sugiyama KTN1 CG1 KIAA0004 EENKWKVKVDESHKTIKQMQssFTSsEQELERLRSENKDIE
Q86VQ1 S206 Sugiyama GLCCI1 PRDPHVHYPSCMKDKATQTPsCWAEEGAEKRSHQRsAsWGs
Q8IX94 S140 Sugiyama CTAGE4 AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8N129 S45 Sugiyama CNPY4 PSEC0237 UNQ1909/PRO4354 KEEDDDTERLPSKCEVCKLLstELQAELsRtGRsREVLELG
Q8N1G4 T371 Sugiyama LRRC47 KIAA1185 ALKRFLTSQTKLHEDLCEKRtAAtLAtHELRAVKGPLLYCA
Q8N1G4 T374 Sugiyama LRRC47 KIAA1185 RFLTSQTKLHEDLCEKRtAAtLAtHELRAVKGPLLYCARPP
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBP7 S225 Sugiyama PCSK9 NARC1 PSEC0052 FENVPEEDGTRFHRQASKCDsHGtHLAGVVSGRDAGVAKGA
Q8NEJ9 S214 Sugiyama NGDN C14orf120 ERAKRRALsSsVIRELKEQYsDAPEEIRDARHPHVTRQSQE
Q8NI08 S208 Sugiyama NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993 DKLPDADLARKALKPIERVLsstsEEDEPGVVKFLKMNCRY
Q8NI08 S441 Sugiyama NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993 ELSsQTGGGMHKKDTLKECLsLDPEERKKAESQINNSAVEM
Q8TE77 S37 Sugiyama SSH3 SSH3L tPVGPWDQAVQRRSRLQRRQsFAVLRGAVLGLQDGGDNDDA
Q8WUI4 S155 SIGNOR HDAC7 HDAC7A PPVPSLPSDPPEHFPLRKtVsEPNLKLRYKPKKSLERRKNP
Q8WUI4 S358 SIGNOR HDAC7 HDAC7A LMTTERLSGSGLHWPLSRtRsEPLPPSATAPPPPGPMQPRL
Q8WUI4 S405 Sugiyama HDAC7 HDAC7A VQVIKRSAKPSEKPRLRQIPsAEDLEtDGGGPGQVVDDGLE
Q8WUI4 S486 Sugiyama HDAC7 HDAC7A GDtVLLPLAQGGHRPLsRAQssPAAPAsLSAPEPASQARVL
Q8WYL5 S978 SIGNOR SSH1 KIAA1298 SSH1L IETRLRLAGLTVssPLKRSHsLAKLGsLtFstEDLsSEADP
Q92625 S663 Sugiyama ANKS1A ANKS1 KIAA0229 ODIN sRsEsLsNCsIGKKRLEKsPsFAsEWDEIEKIMssIGEGID
Q96E11 S239 Sugiyama MRRF LKKSKDTVsEDtIRLIEKQIsQMADDtVAELDRHLAVKTKE
Q96G46 T240 Sugiyama DUS3L KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96JJ7 S268 Sugiyama TMX3 KIAA1830 TXNDC10 LVALAVIDEKNTSVEHTRLKsIIQEVARDYRDLFHRDFQFG
Q96T37 S344 Sugiyama RBM15 OTT OTT1 PRDLERERDYPFYERVRPAYsLEPRVGAGAGAAPFREVDEI
Q99543 S275 Sugiyama DNAJC2 MPHOSPH11 MPP11 ZRF1 RAQRKKEEMNRIRtLVDNAysCDPRIKKFKEEEKAKKEAEK
Q99575 S816 Sugiyama POP1 KIAA0061 VAATGSHLCVLRSRKLLKQLsAWCGPSSEDSRGGRRAPGRG
Q9BQ52 S796 Sugiyama ELAC2 HPC2 EEMEERREKRELRQVRAALLsRELAGGLEDGEPQQKRAHTE
Q9BXP5 S422 Sugiyama SRRT ARS2 ASR2 EKPKDAAGLECKPRPLHKTCsLFMRNIAPNISRAEIIsLCK
Q9BY44 S528 Sugiyama EIF2A CDA02 MSTP004 MSTP089 DLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKAIE
Q9BYX7 S365 Sugiyama POTEKP ACTBL3 FKSG30 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9C0C9 S399 Sugiyama UBE2O KIAA1734 EGsMAKKVKRLLKKQVVRIMsCsPDtQCsRDHsMEDPDKKG
Q9GZY8 S155 SIGNOR MFF C2orf33 AD030 AD033 GL004 PPttPQNEEIRAVGRLKRERsMsENAVRQNGQLVRNDsLWH
Q9GZY8 S172 SIGNOR|PSP MFF C2orf33 AD030 AD033 GL004 RERsMsENAVRQNGQLVRNDsLWHRsDsAPRNKISRFQAPI
Q9GZY8 S275 SIGNOR MFF C2orf33 AD030 AD033 GL004 RGGsAAAtsNPHHDNVRYGIsNIDTTIEGTSDDLTVVDAAS
Q9H0H5 S206 Sugiyama RACGAP1 KIAA1478 MGCRACGAP tsRQFVDGPPGPVKKtRsIGsAVDQGNEsIVAKTTVTVPND
Q9H3N1 S270 Sugiyama TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268 EAEsKEGtNKDFPQNAIRQRsLGPsLAtDKs__________
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H788 S316 Sugiyama SH2D4A PPP1R38 SH2A NSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRAG
Q9H9Q2 S225 Sugiyama COPS7B CSN7B TQQQVEAEVTNIKKTLKAtAsSsAQEMEQQLAERECPPHAE
Q9H9Q2 T223 Sugiyama COPS7B CSN7B NRTQQQVEAEVTNIKKTLKAtAsSsAQEMEQQLAERECPPH
Q9HB07 S196 Sugiyama MYG1 C12orf10 DNGISQWAEGEPRyALttTLsARVARLNPTWNHPDQDTEAG
Q9NQ55 S47 Sugiyama PPAN BXDC3 SSF1 ANPHSFVFTRGCTGRNIRQLsLDVRRVMEPLTASRLQVRKK
Q9NR30 S706 Sugiyama DDX21 PTASVTEIQEKWHDSRRWQLsVATEQPELEGPREGYGGFRG
Q9NXH9 S524 Sugiyama TRMT1 KECPVKRERLsETsPAFRILsVEPRLQANFTIREDANPSSR
Q9NZB2 S417 Sugiyama FAM120A C9orf10 KIAA0183 OSSA LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UKV3 S987 Sugiyama ACIN1 ACINUS KIAA0670 EVKKVTLGDtLtRRsIsQQKsGVsITIDDPVRtAQVPsPPR
Q9UKV8 S387 Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9ULD2 S1203 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9UMZ2 S752 Sugiyama SYNRG AP1GBP1 SYNG VKGGQNSTAASTKyDVFRQLsLEGsGLGVEDLKDNtPSGKs
Q9UNF1 S264 Sugiyama MAGED2 BCG1 sLRsPKARRGKARRRAAKLQssQEPEAPPPRDVALLQGRAN
Q9UNH7 S55 Sugiyama SNX6 DISDALSERDKVKFTVHTKSsLPNFKQNEFSVVRQHEEFIW
Q9UNX3 S9 Sugiyama RPL26L1 RPL26P1 ____________MKFNPFVtsDRsKNRKRHFNAPSHVRRKI
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UPN9 S1015 Sugiyama TRIM33 KIAA1113 RFG7 TIF1G KIIKKPMDLSTVKKKLQKKHsQHYQIPDDFVADVRLIFKNC
Q9UPY8 S176 Sugiyama MAPRE3 AVPQRtsPtGPKNMQTSGRLsNVAPPCILRKNPPSARNGGH
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQL6 S259 SIGNOR HDAC5 KIAA0600 KLPLPGPYDSRDDFPLRKTAsEPNLKVRSRLKQKVAERRss
Q9UQL6 S498 SIGNOR|EPSD|PSP HDAC5 KIAA0600 ATSMRTVGKLPRHRPLSRtQssPLPQSPQALQQLVMQQQHQ
Q9Y2B0 T168 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 LIEFFsREADNVKDKLCSKRtDLCDHALHIsHDEL______
Q9Y2X7 S46 SIGNOR|EPSD|PSP GIT1 RGVLVCDECCSVHRSLGRHIsIVKHLRHsAWPPTLLQMVHT
Q9Y3B8 S203 Sugiyama REXO2 SFN SMFN CGI-114 EYEFAPKKAAsHRALDDIsEsIKELQFyRNNIFKKKIDEKK
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y580 S136 Sugiyama RBM7 RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Q9Y5A9 S394 Sugiyama YTHDF2 HGRG8 SQAGSGStPSEPHPVLEKLRsINNYNPKDFDWNLKHGRVFI
Q9Y5B9 S650 Sugiyama SUPT16H FACT140 FACTP140 KRYKTREAEEKEKEGIVKQDsLVINLNRsNPKLKDLYIRPN
Q9Y618 T35 Sugiyama NCOR2 CTG26 TEPRYPPHSLSYPVQIARTHtDVGLLEYQHHSRDYASHLSP
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Attenuation phase R-HSA-3371568 5.270686e-08 7.278 0 0
HSF1-dependent transactivation R-HSA-3371571 7.138640e-08 7.146 0 0
NRAGE signals death through JNK R-HSA-193648 1.020336e-07 6.991 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.262095e-07 6.899 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.184246e-07 6.497 0 0
Chromatin modifying enzymes R-HSA-3247509 1.103945e-06 5.957 0 0
G alpha (12/13) signalling events R-HSA-416482 1.302254e-06 5.885 0 0
Chromatin organization R-HSA-4839726 3.578078e-06 5.446 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.318383e-06 5.365 0 0
Death Receptor Signaling R-HSA-73887 6.397939e-06 5.194 0 0
Apoptotic execution phase R-HSA-75153 6.824158e-06 5.166 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.058066e-05 4.975 0 0
Cellular response to heat stress R-HSA-3371556 1.134910e-05 4.945 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.347046e-05 4.871 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.807741e-05 4.743 0 0
HSF1 activation R-HSA-3371511 3.183818e-05 4.497 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.735872e-05 4.428 0 0
Cell Cycle R-HSA-1640170 4.034054e-05 4.394 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.549336e-05 4.342 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.977784e-05 4.098 0 0
Signal Transduction R-HSA-162582 9.259113e-05 4.033 0 0
HDMs demethylate histones R-HSA-3214842 1.066861e-04 3.972 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.111899e-04 3.954 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.111899e-04 3.954 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.527187e-04 3.816 0 0
Cell Cycle, Mitotic R-HSA-69278 2.322557e-04 3.634 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.607739e-04 3.443 0 0
Axon guidance R-HSA-422475 4.413640e-04 3.355 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.881247e-04 3.311 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.087711e-04 3.293 0 0
Cell Cycle Checkpoints R-HSA-69620 8.252450e-04 3.083 0 0
Activation of RAC1 R-HSA-428540 1.101314e-03 2.958 0 0
Rab regulation of trafficking R-HSA-9007101 1.120939e-03 2.950 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.185181e-03 2.926 0 0
Nervous system development R-HSA-9675108 1.197214e-03 2.922 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.299181e-03 2.886 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.274675e-03 2.895 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.261780e-03 2.899 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.417989e-03 2.848 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.507335e-03 2.822 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.742916e-03 2.759 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.212338e-03 2.655 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.537381e-03 2.596 0 0
Signaling by Hippo R-HSA-2028269 3.306001e-03 2.481 0 0
Neurexins and neuroligins R-HSA-6794361 3.716804e-03 2.430 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.022683e-03 2.395 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.022683e-03 2.395 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.040092e-03 2.394 0 0
Semaphorin interactions R-HSA-373755 4.125105e-03 2.385 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.392812e-03 2.357 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.531466e-03 2.344 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.609313e-03 2.336 0 0
Signaling by ROBO receptors R-HSA-376176 4.875596e-03 2.312 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.158352e-03 2.287 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.481771e-03 2.261 0 0
Specification of the neural plate border R-HSA-9834899 5.739576e-03 2.241 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.886510e-03 2.230 0 0
Mitotic Prometaphase R-HSA-68877 5.755320e-03 2.240 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.045297e-03 2.219 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.069706e-03 2.217 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.394459e-03 2.194 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 7.384485e-03 2.132 0 0
PIP3 activates AKT signaling R-HSA-1257604 7.354534e-03 2.133 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.782698e-03 2.109 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.558518e-03 2.122 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 8.167617e-03 2.088 0 0
Neurodegenerative Diseases R-HSA-8863678 8.167617e-03 2.088 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.735724e-03 2.059 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.735724e-03 2.059 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.735724e-03 2.059 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.786383e-03 2.056 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 9.120398e-03 2.040 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.651796e-03 2.015 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.009364e-02 1.996 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.046076e-02 1.980 0 0
Long-term potentiation R-HSA-9620244 1.009364e-02 1.996 0 0
TBC/RABGAPs R-HSA-8854214 1.023942e-02 1.990 0 0
Specification of primordial germ cells R-HSA-9827857 1.057849e-02 1.976 0 0
PI Metabolism R-HSA-1483255 1.169624e-02 1.932 0 0
Regulation of TP53 Activity R-HSA-5633007 1.117057e-02 1.952 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.172707e-02 1.931 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.172707e-02 1.931 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.193107e-02 1.923 0 0
TRP channels R-HSA-3295583 1.234716e-02 1.908 0 0
Membrane Trafficking R-HSA-199991 1.316819e-02 1.880 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.523716e-02 1.817 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.523716e-02 1.817 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.523716e-02 1.817 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.496005e-02 1.825 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.664556e-02 1.779 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.778065e-02 1.750 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.778065e-02 1.750 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.713150e-02 1.766 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.778065e-02 1.750 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.965806e-02 1.706 0 0
Apoptosis R-HSA-109581 2.043830e-02 1.690 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.345379e-02 1.630 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.345379e-02 1.630 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.345379e-02 1.630 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.345379e-02 1.630 0 0
Signaling by MAPK mutants R-HSA-9652817 2.345379e-02 1.630 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.379477e-02 1.624 0 0
EPH-Ephrin signaling R-HSA-2682334 2.197367e-02 1.658 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.379477e-02 1.624 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.345379e-02 1.630 0 0
Post NMDA receptor activation events R-HSA-438064 2.169739e-02 1.664 0 0
Kinesins R-HSA-983189 2.344287e-02 1.630 0 0
Neuronal System R-HSA-112316 2.395305e-02 1.621 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.434193e-02 1.614 0 0
M Phase R-HSA-68886 2.470815e-02 1.607 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.504949e-02 1.601 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.560592e-02 1.592 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.778635e-02 1.556 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.598845e-02 1.585 0 0
Trafficking of AMPA receptors R-HSA-399719 2.962459e-02 1.528 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.281110e-02 1.484 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.281110e-02 1.484 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.281110e-02 1.484 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.273134e-02 1.485 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.273134e-02 1.485 0 0
RET signaling R-HSA-8853659 3.272747e-02 1.485 0 0
Signaling by RAS mutants R-HSA-6802949 3.281110e-02 1.484 0 0
Ion homeostasis R-HSA-5578775 2.835045e-02 1.547 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.032796e-02 1.518 0 0
Calmodulin induced events R-HSA-111933 3.272747e-02 1.485 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.054233e-02 1.515 0 0
Mitotic Anaphase R-HSA-68882 2.884025e-02 1.540 0 0
CaM pathway R-HSA-111997 3.272747e-02 1.485 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.193239e-02 1.496 0 0
DAG and IP3 signaling R-HSA-1489509 2.893210e-02 1.539 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.094869e-02 1.509 0 0
FLT3 Signaling R-HSA-9607240 3.084629e-02 1.511 0 0
Centrosome maturation R-HSA-380287 3.392415e-02 1.469 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.419086e-02 1.466 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.452464e-02 1.462 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.516569e-02 1.454 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.517818e-02 1.454 0 0
Separation of Sister Chromatids R-HSA-2467813 3.558998e-02 1.449 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.585004e-02 1.446 0 0
cGMP effects R-HSA-418457 3.585004e-02 1.446 0 0
Regulation of KIT signaling R-HSA-1433559 3.585004e-02 1.446 0 0
Ephrin signaling R-HSA-3928664 3.717194e-02 1.430 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.988300e-02 1.399 0 0
Polo-like kinase mediated events R-HSA-156711 3.717194e-02 1.430 0 0
Cardiogenesis R-HSA-9733709 3.988300e-02 1.399 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.760137e-02 1.322 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.760137e-02 1.322 0 0
Regulation of PTEN localization R-HSA-8948747 4.669506e-02 1.331 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.669506e-02 1.331 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.450527e-02 1.352 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.450527e-02 1.352 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.582978e-02 1.339 0 0
HATs acetylate histones R-HSA-3214847 4.393794e-02 1.357 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.484909e-02 1.348 0 0
Rap1 signalling R-HSA-392517 4.484909e-02 1.348 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.760137e-02 1.322 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.760137e-02 1.322 0 0
Dopamine receptors R-HSA-390651 4.760137e-02 1.322 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.381783e-02 1.358 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.546907e-02 1.342 0 0
Muscle contraction R-HSA-397014 4.730352e-02 1.325 0 0
Cellular Senescence R-HSA-2559583 4.589408e-02 1.338 0 0
RAB geranylgeranylation R-HSA-8873719 4.387382e-02 1.358 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.672627e-02 1.330 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.863324e-02 1.313 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.289996e-02 1.277 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.289996e-02 1.277 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.355544e-02 1.271 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.378788e-02 1.269 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.435980e-02 1.265 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.173354e-02 1.209 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 6.173354e-02 1.209 0 0
Type I hemidesmosome assembly R-HSA-446107 6.179151e-02 1.209 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.892233e-02 1.230 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.740671e-02 1.241 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.796149e-02 1.237 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.672289e-02 1.246 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 6.179151e-02 1.209 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.325042e-02 1.199 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.327369e-02 1.199 0 0
G2/M Transition R-HSA-69275 6.388407e-02 1.195 0 0
mRNA 3'-end processing R-HSA-72187 6.414468e-02 1.193 0 0
Programmed Cell Death R-HSA-5357801 6.481594e-02 1.188 0 0
Cardiac conduction R-HSA-5576891 6.518181e-02 1.186 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 6.578883e-02 1.182 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.578883e-02 1.182 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 6.578883e-02 1.182 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 6.578883e-02 1.182 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 6.578883e-02 1.182 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 6.578883e-02 1.182 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 6.578883e-02 1.182 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.677232e-02 1.175 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.870983e-02 1.163 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.546786e-02 1.122 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.546786e-02 1.122 0 0
FOXO-mediated transcription R-HSA-9614085 7.012404e-02 1.154 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.933452e-02 1.159 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 6.870983e-02 1.163 0 0
MAPK family signaling cascades R-HSA-5683057 6.843911e-02 1.165 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.185842e-02 1.144 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.601914e-02 1.119 0 0
Ca-dependent events R-HSA-111996 7.698323e-02 1.114 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.773141e-02 1.109 0 0
NGF-stimulated transcription R-HSA-9031628 7.774096e-02 1.109 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.848497e-02 1.105 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.250441e-01 0.903 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.250441e-01 0.903 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.007635e-01 0.997 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.007635e-01 0.997 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.007635e-01 0.997 0 0
Potassium transport channels R-HSA-1296067 1.007635e-01 0.997 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.007635e-01 0.997 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.007635e-01 0.997 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.007635e-01 0.997 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.007635e-01 0.997 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.007635e-01 0.997 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.007635e-01 0.997 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.007635e-01 0.997 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.007635e-01 0.997 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.344584e-01 0.630 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.344584e-01 0.630 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.344584e-01 0.630 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.344584e-01 0.630 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.344584e-01 0.630 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.344584e-01 0.630 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.344584e-01 0.630 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.344584e-01 0.630 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.344584e-01 0.630 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.344584e-01 0.630 0 0
Defective SLC2A10 causes arterial tortuosity syndrome (ATS) R-HSA-5619068 2.344584e-01 0.630 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.344584e-01 0.630 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.447053e-01 0.840 0 0
Axonal growth stimulation R-HSA-209563 1.447053e-01 0.840 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.447053e-01 0.840 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 1.447053e-01 0.840 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 9.330109e-02 1.030 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 9.330109e-02 1.030 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.914603e-02 1.102 0 0
Lipophagy R-HSA-9613354 7.914603e-02 1.102 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.209415e-01 0.917 0 0
Regulation of gap junction activity R-HSA-191650 1.917215e-01 0.717 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.917215e-01 0.717 0 0
NADE modulates death signalling R-HSA-205025 1.917215e-01 0.717 0 0
HCN channels R-HSA-1296061 1.917215e-01 0.717 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.917215e-01 0.717 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.917215e-01 0.717 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.917215e-01 0.717 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.917215e-01 0.717 0 0
FGFR4 mutant receptor activation R-HSA-1839128 3.301960e-01 0.481 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.301960e-01 0.481 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.301960e-01 0.481 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.301960e-01 0.481 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.301960e-01 0.481 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.301960e-01 0.481 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.301960e-01 0.481 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.301960e-01 0.481 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.301960e-01 0.481 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.301960e-01 0.481 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.301960e-01 0.481 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.301960e-01 0.481 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.301960e-01 0.481 0 0
Intestinal infectious diseases R-HSA-8942233 3.301960e-01 0.481 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.301960e-01 0.481 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.301960e-01 0.481 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.301960e-01 0.481 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.301960e-01 0.481 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.301960e-01 0.481 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.301960e-01 0.481 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.301960e-01 0.481 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.301960e-01 0.481 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.301960e-01 0.481 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.301960e-01 0.481 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.511557e-01 0.821 0 0
SOS-mediated signalling R-HSA-112412 1.511557e-01 0.821 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.201452e-01 0.920 0 0
Signaling by APC mutants R-HSA-4839744 1.201452e-01 0.920 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.201452e-01 0.920 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.201452e-01 0.920 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.201452e-01 0.920 0 0
IRS activation R-HSA-74713 2.403570e-01 0.619 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.403570e-01 0.619 0 0
G2 Phase R-HSA-68911 2.403570e-01 0.619 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.834554e-01 0.736 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.834554e-01 0.736 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.434543e-01 0.843 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.434543e-01 0.843 0 0
DCC mediated attractive signaling R-HSA-418885 1.138349e-01 0.944 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.138349e-01 0.944 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.059243e-01 0.975 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.059243e-01 0.975 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.327666e-01 0.877 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.327666e-01 0.877 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.683692e-01 0.774 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.173610e-01 0.663 0 0
WNT mediated activation of DVL R-HSA-201688 2.173610e-01 0.663 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.173610e-01 0.663 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.894724e-01 0.538 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.894724e-01 0.538 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.894724e-01 0.538 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.894724e-01 0.538 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.894724e-01 0.538 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.894724e-01 0.538 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.894724e-01 0.538 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.139656e-01 0.383 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.139656e-01 0.383 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.139656e-01 0.383 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.139656e-01 0.383 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.139656e-01 0.383 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.900003e-02 1.102 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.217569e-01 0.915 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.530019e-01 0.815 0 0
Formation of axial mesoderm R-HSA-9796292 1.946694e-01 0.711 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.946694e-01 0.711 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.238487e-02 1.084 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.386797e-01 0.858 0 0
Formation of apoptosome R-HSA-111458 2.524156e-01 0.598 0 0
Regulation of the apoptosome activity R-HSA-9627069 2.524156e-01 0.598 0 0
PI3K/AKT activation R-HSA-198203 2.524156e-01 0.598 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.524156e-01 0.598 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.524156e-01 0.598 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.014881e-01 0.994 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 1.744256e-01 0.758 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.256668e-01 0.901 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.256668e-01 0.901 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.566292e-01 0.805 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.221268e-01 0.653 0 0
Removal of the Flap Intermediate R-HSA-69166 2.221268e-01 0.653 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.381876e-01 0.471 0 0
CREB phosphorylation R-HSA-199920 3.381876e-01 0.471 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.381876e-01 0.471 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 3.381876e-01 0.471 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.381876e-01 0.471 0 0
RAF activation R-HSA-5673000 1.034046e-01 0.985 0 0
PKA activation R-HSA-163615 1.969116e-01 0.706 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 1.969116e-01 0.706 0 0
Notch-HLH transcription pathway R-HSA-350054 1.755324e-01 0.756 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.881956e-01 0.540 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.881956e-01 0.540 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 2.881956e-01 0.540 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.571509e-01 0.804 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.411790e-01 0.850 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.505126e-01 0.601 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.505126e-01 0.601 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.203266e-01 0.657 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.262105e-01 0.899 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 8.485531e-02 1.071 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.125803e-01 0.949 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.381572e-01 0.860 0 0
Striated Muscle Contraction R-HSA-390522 1.713294e-01 0.766 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.713294e-01 0.766 0 0
Phosphorylation of the APC/C R-HSA-176412 2.796013e-01 0.553 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.243157e-01 0.489 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.243157e-01 0.489 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.243157e-01 0.489 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.858349e-01 0.414 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.858349e-01 0.414 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.858349e-01 0.414 0 0
Netrin mediated repulsion signals R-HSA-418886 3.858349e-01 0.414 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.858349e-01 0.414 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.858349e-01 0.414 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.858349e-01 0.414 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.858349e-01 0.414 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.858349e-01 0.414 0 0
Defective CYP1B1 causes Glaucoma R-HSA-5579000 4.872627e-01 0.312 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.872627e-01 0.312 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.872627e-01 0.312 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.872627e-01 0.312 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.872627e-01 0.312 0 0
Phenylketonuria R-HSA-2160456 4.872627e-01 0.312 0 0
Invadopodia formation R-HSA-8941237 4.872627e-01 0.312 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.872627e-01 0.312 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.872627e-01 0.312 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.277812e-02 1.082 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.225086e-01 0.912 0 0
Meiotic synapsis R-HSA-1221632 1.225086e-01 0.912 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.874069e-01 0.727 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.824879e-01 0.739 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.091757e-01 0.510 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.091757e-01 0.510 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.604329e-01 0.443 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.604329e-01 0.443 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.604329e-01 0.443 0 0
IRAK1 recruits IKK complex R-HSA-937039 3.604329e-01 0.443 0 0
Polymerase switching R-HSA-69091 3.604329e-01 0.443 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 3.604329e-01 0.443 0 0
Leading Strand Synthesis R-HSA-69109 3.604329e-01 0.443 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.813466e-01 0.551 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.390294e-01 0.470 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.319197e-01 0.365 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.319197e-01 0.365 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.319197e-01 0.365 0 0
Activation of RAS in B cells R-HSA-1169092 4.319197e-01 0.365 0 0
Formation of annular gap junctions R-HSA-196025 4.319197e-01 0.365 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.689052e-01 0.570 0 0
snRNP Assembly R-HSA-191859 1.917284e-01 0.717 0 0
Metabolism of non-coding RNA R-HSA-194441 1.917284e-01 0.717 0 0
FGFR4 ligand binding and activation R-HSA-190322 3.962466e-01 0.402 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.607781e-01 0.794 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.138515e-01 0.944 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.759798e-01 0.559 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.759798e-01 0.559 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.689698e-01 0.433 0 0
PKA activation in glucagon signalling R-HSA-164378 3.689698e-01 0.433 0 0
Signaling by Erythropoietin R-HSA-9006335 3.271954e-01 0.485 0 0
Late endosomal microautophagy R-HSA-9615710 3.271954e-01 0.485 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.271954e-01 0.485 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.101995e-01 0.508 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.101995e-01 0.508 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.721613e-01 0.565 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.504930e-01 0.455 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.725960e-01 0.429 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.988192e-01 0.399 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.988192e-01 0.399 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.314986e-01 0.365 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.314986e-01 0.365 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.760879e-01 0.322 0 0
Gap junction degradation R-HSA-190873 4.760879e-01 0.322 0 0
ALK mutants bind TKIs R-HSA-9700645 4.760879e-01 0.322 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.513961e-01 0.259 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.513961e-01 0.259 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.513961e-01 0.259 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.513961e-01 0.259 0 0
betaKlotho-mediated ligand binding R-HSA-1307965 5.513961e-01 0.259 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.513961e-01 0.259 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.513961e-01 0.259 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.284165e-01 0.641 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.284165e-01 0.641 0 0
Tight junction interactions R-HSA-420029 3.986954e-01 0.399 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.284163e-01 0.368 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.284163e-01 0.368 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.284163e-01 0.368 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.284163e-01 0.368 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.284163e-01 0.368 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.693752e-01 0.771 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.809396e-01 0.551 0 0
Erythropoietin activates RAS R-HSA-9027284 4.659711e-01 0.332 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.659711e-01 0.332 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.659711e-01 0.332 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 4.659711e-01 0.332 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.659711e-01 0.332 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.721911e-01 0.429 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 4.576166e-01 0.339 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.576166e-01 0.339 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 5.180980e-01 0.286 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.180980e-01 0.286 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.180980e-01 0.286 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.180980e-01 0.286 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.169382e-01 0.380 0 0
mRNA Splicing R-HSA-72172 2.495742e-01 0.603 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.504413e-01 0.346 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.504413e-01 0.346 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.504413e-01 0.346 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.504413e-01 0.346 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.655029e-01 0.437 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.461976e-01 0.461 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.294640e-01 0.639 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.440892e-01 0.353 0 0
HIV Transcription Elongation R-HSA-167169 4.383452e-01 0.358 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.383452e-01 0.358 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.383452e-01 0.358 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.862924e-01 0.313 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.758891e-01 0.322 0 0
HIV elongation arrest and recovery R-HSA-167287 4.758891e-01 0.322 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.758891e-01 0.322 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.758891e-01 0.322 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.758891e-01 0.322 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 5.143327e-01 0.289 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.318932e-01 0.274 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.318932e-01 0.274 0 0
FGFR2b ligand binding and activation R-HSA-190377 5.577990e-01 0.254 0 0
Activation of AMPA receptors R-HSA-399710 6.075109e-01 0.216 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.075109e-01 0.216 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.075109e-01 0.216 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.075109e-01 0.216 0 0
Defective F9 activation R-HSA-9673221 6.075109e-01 0.216 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.075109e-01 0.216 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.075109e-01 0.216 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.075109e-01 0.216 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.075109e-01 0.216 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.369562e-01 0.360 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.663456e-01 0.331 0 0
G1/S-Specific Transcription R-HSA-69205 5.125154e-01 0.290 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.255052e-01 0.279 0 0
DAP12 signaling R-HSA-2424491 5.255052e-01 0.279 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.255052e-01 0.279 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.255052e-01 0.279 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.346313e-01 0.272 0 0
EGFR downregulation R-HSA-182971 5.495295e-01 0.260 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.495295e-01 0.260 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.495295e-01 0.260 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.232092e-01 0.281 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.386234e-01 0.269 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.681433e-01 0.246 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.681433e-01 0.246 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.681433e-01 0.246 0 0
Deadenylation of mRNA R-HSA-429947 5.681433e-01 0.246 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 5.951113e-01 0.225 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.951113e-01 0.225 0 0
ERKs are inactivated R-HSA-202670 5.951113e-01 0.225 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.623448e-01 0.250 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.623448e-01 0.250 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.623448e-01 0.250 0 0
Nucleosome assembly R-HSA-774815 5.623448e-01 0.250 0 0
Transcription of the HIV genome R-HSA-167172 5.612596e-01 0.251 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.678302e-01 0.246 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.929756e-01 0.227 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.937695e-01 0.226 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.957172e-01 0.225 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.957172e-01 0.225 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.981870e-01 0.223 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.009048e-01 0.221 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.183098e-01 0.209 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.177891e-01 0.209 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.215057e-01 0.207 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.300113e-01 0.201 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.300113e-01 0.201 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.016371e-01 0.993 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.811679e-01 0.742 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.815574e-01 0.550 0 0
PKR-mediated signaling R-HSA-9833482 6.270779e-01 0.203 0 0
Integrin signaling R-HSA-354192 1.559069e-01 0.807 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.059506e-01 0.392 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.630851e-01 0.249 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.630851e-01 0.249 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.439327e-02 1.074 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.258665e-01 0.279 0 0
Signaling by EGFR R-HSA-177929 4.837680e-01 0.315 0 0
G1/S Transition R-HSA-69206 4.120363e-01 0.385 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.689698e-01 0.433 0 0
Formation of definitive endoderm R-HSA-9823730 1.217569e-01 0.915 0 0
p75NTR signals via NF-kB R-HSA-193639 2.505126e-01 0.601 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.962466e-01 0.402 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.059191e-01 0.514 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.346313e-01 0.272 0 0
Signaling by ERBB2 R-HSA-1227986 4.235855e-01 0.373 0 0
Lagging Strand Synthesis R-HSA-69186 4.576166e-01 0.339 0 0
Developmental Cell Lineages R-HSA-9734767 5.092499e-01 0.293 0 0
Intra-Golgi traffic R-HSA-6811438 3.337763e-01 0.477 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.284163e-01 0.368 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.948785e-02 1.048 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.596401e-01 0.444 0 0
ESR-mediated signaling R-HSA-8939211 3.455982e-01 0.461 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.120363e-01 0.385 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.120363e-01 0.385 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.268925e-01 0.897 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.530019e-01 0.815 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.571562e-02 1.067 0 0
Activation of the pre-replicative complex R-HSA-68962 2.102391e-01 0.677 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.589853e-01 0.587 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.811456e-01 0.551 0 0
Signaling by FGFR4 R-HSA-5654743 3.733211e-01 0.428 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.120363e-01 0.385 0 0
TGFBR3 expression R-HSA-9839394 3.986954e-01 0.399 0 0
Hedgehog 'off' state R-HSA-5610787 6.206840e-01 0.207 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.530019e-01 0.815 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.243157e-01 0.489 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.277812e-02 1.082 0 0
DNA strand elongation R-HSA-69190 3.973790e-01 0.401 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.555669e-01 0.255 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.623448e-01 0.250 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.936942e-01 0.226 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.551222e-01 0.809 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.734963e-01 0.428 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.505126e-01 0.601 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.312870e-01 0.480 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.284163e-01 0.368 0 0
S Phase R-HSA-69242 2.334200e-01 0.632 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.693641e-01 0.328 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.352111e-01 0.475 0 0
TNF signaling R-HSA-75893 1.551222e-01 0.809 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.596401e-01 0.444 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.832367e-01 0.417 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.184702e-01 0.209 0 0
Signaling by FGFR3 R-HSA-5654741 5.623448e-01 0.250 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.914603e-02 1.102 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.524156e-01 0.598 0 0
MAP2K and MAPK activation R-HSA-5674135 1.262105e-01 0.899 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.968226e-02 1.047 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.712257e-01 0.327 0 0
G2/M Checkpoints R-HSA-69481 5.279906e-01 0.277 0 0
DNA Double Strand Break Response R-HSA-5693606 5.446571e-01 0.264 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.162083e-01 0.287 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.420257e-01 0.848 0 0
G1 Phase R-HSA-69236 2.636798e-01 0.579 0 0
Cyclin D associated events in G1 R-HSA-69231 2.636798e-01 0.579 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.091757e-01 0.510 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.411790e-01 0.850 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.712257e-01 0.327 0 0
MHC class II antigen presentation R-HSA-2132295 2.930135e-01 0.533 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.894724e-01 0.538 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 2.894724e-01 0.538 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.744256e-01 0.758 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.858349e-01 0.414 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.573438e-01 0.589 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.962466e-01 0.402 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.314986e-01 0.365 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 4.760879e-01 0.322 0 0
Regulation of CDH11 function R-HSA-9762292 5.180980e-01 0.286 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 4.596271e-01 0.338 0 0
Peptide chain elongation R-HSA-156902 4.222164e-01 0.374 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.577990e-01 0.254 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.192573e-01 0.378 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.559069e-01 0.807 0 0
Apoptotic factor-mediated response R-HSA-111471 3.689698e-01 0.433 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.101995e-01 0.508 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.383452e-01 0.358 0 0
Diseases of Immune System R-HSA-5260271 4.383452e-01 0.358 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.255052e-01 0.279 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.987804e-01 0.223 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.173610e-01 0.663 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.507240e-01 0.822 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.613227e-01 0.792 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.224663e-01 0.492 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.862924e-01 0.313 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.023736e-01 0.299 0 0
TCR signaling R-HSA-202403 5.628536e-01 0.250 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.177891e-01 0.209 0 0
Netrin-1 signaling R-HSA-373752 9.439201e-02 1.025 0 0
Generation of second messenger molecules R-HSA-202433 1.824879e-01 0.739 0 0
Triglyceride catabolism R-HSA-163560 5.125154e-01 0.290 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.046375e-02 1.044 0 0
G-protein mediated events R-HSA-112040 1.363644e-01 0.865 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.914603e-02 1.102 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.917215e-01 0.717 0 0
Adrenoceptors R-HSA-390696 1.834554e-01 0.736 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.834554e-01 0.736 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.327666e-01 0.877 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.173610e-01 0.663 0 0
Signaling by WNT in cancer R-HSA-4791275 1.411790e-01 0.850 0 0
NF-kB is activated and signals survival R-HSA-209560 3.243157e-01 0.489 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 3.604329e-01 0.443 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.319197e-01 0.365 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 3.962466e-01 0.402 0 0
Unwinding of DNA R-HSA-176974 4.760879e-01 0.322 0 0
Telomere C-strand synthesis initiation R-HSA-174430 4.659711e-01 0.332 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.666818e-01 0.247 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.728916e-01 0.242 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.957172e-01 0.225 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 6.300113e-01 0.201 0 0
Opioid Signalling R-HSA-111885 3.707282e-01 0.431 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.826625e-01 0.316 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.826625e-01 0.316 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.306588e-01 0.275 0 0
Cilium Assembly R-HSA-5617833 3.709127e-01 0.431 0 0
Mitotic Prophase R-HSA-68875 4.282998e-01 0.368 0 0
Homology Directed Repair R-HSA-5693538 5.924222e-01 0.227 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.589853e-01 0.587 0 0
Signaling by FGFR in disease R-HSA-1226099 5.348240e-01 0.272 0 0
Signal attenuation R-HSA-74749 2.524156e-01 0.598 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.918367e-01 0.717 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 1.918367e-01 0.717 0 0
Repression of WNT target genes R-HSA-4641265 3.604329e-01 0.443 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.041152e-01 0.517 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.017257e-01 0.520 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.671846e-01 0.331 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.807283e-01 0.318 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.037361e-01 0.219 0 0
Signaling by WNT R-HSA-195721 6.117074e-01 0.213 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 3.962466e-01 0.402 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.563111e-01 0.255 0 0
PLC beta mediated events R-HSA-112043 8.485531e-02 1.071 0 0
Meiosis R-HSA-1500620 2.670512e-01 0.573 0 0
Co-stimulation by CD28 R-HSA-389356 1.357062e-01 0.867 0 0
Integration of energy metabolism R-HSA-163685 3.131166e-01 0.504 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.815574e-01 0.550 0 0
Cellular response to chemical stress R-HSA-9711123 4.235223e-01 0.373 0 0
Gastrulation R-HSA-9758941 3.107525e-01 0.508 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.511557e-01 0.821 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 9.630853e-02 1.016 0 0
Calcineurin activates NFAT R-HSA-2025928 2.173610e-01 0.663 0 0
Abacavir transmembrane transport R-HSA-2161517 3.381876e-01 0.471 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.713294e-01 0.766 0 0
Signaling by SCF-KIT R-HSA-1433557 1.506742e-01 0.822 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.091757e-01 0.510 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.047439e-01 0.689 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.047439e-01 0.689 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.047439e-01 0.689 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.047439e-01 0.689 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.962466e-01 0.402 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.988192e-01 0.399 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.986954e-01 0.399 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.207960e-01 0.376 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.897495e-01 0.409 0 0
Formation of the posterior neural plate R-HSA-9832991 5.577990e-01 0.254 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.075109e-01 0.216 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.369562e-01 0.360 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.630851e-01 0.249 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.630851e-01 0.249 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.957172e-01 0.225 0 0
Aggrephagy R-HSA-9646399 5.981870e-01 0.223 0 0
Signaling by VEGF R-HSA-194138 9.309002e-02 1.031 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.427949e-01 0.354 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.845447e-01 0.233 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.854285e-01 0.314 0 0
Potassium Channels R-HSA-1296071 2.694211e-01 0.570 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.879382e-01 0.231 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.409832e-01 0.851 0 0
IGF1R signaling cascade R-HSA-2428924 6.229601e-01 0.206 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.739884e-01 0.427 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.440892e-01 0.353 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.505126e-01 0.601 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.459501e-01 0.609 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.184702e-01 0.209 0 0
Transmission across Chemical Synapses R-HSA-112315 2.855028e-01 0.544 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.929756e-01 0.227 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.796013e-01 0.553 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 3.962466e-01 0.402 0 0
Platelet calcium homeostasis R-HSA-418360 3.271954e-01 0.485 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.690120e-01 0.329 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.300113e-01 0.201 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.937695e-01 0.226 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.025101e-01 0.395 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.780123e-01 0.238 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.780123e-01 0.238 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.574402e-01 0.340 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.900146e-01 0.721 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 9.330109e-02 1.030 0 0
Formation of intermediate mesoderm R-HSA-9761174 2.524156e-01 0.598 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.755324e-01 0.756 0 0
Inhibition of nitric oxide production R-HSA-9636249 4.872627e-01 0.312 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.319197e-01 0.365 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.513961e-01 0.259 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.207960e-01 0.376 0 0
Nuclear RNA decay R-HSA-9930044 4.207960e-01 0.376 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.075109e-01 0.216 0 0
Eukaryotic Translation Termination R-HSA-72764 5.527293e-01 0.257 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.818414e-01 0.235 0 0
Diseases of programmed cell death R-HSA-9645723 3.201674e-01 0.495 0 0
RMTs methylate histone arginines R-HSA-3214858 2.636798e-01 0.579 0 0
Autophagy R-HSA-9612973 4.650497e-01 0.333 0 0
Selective autophagy R-HSA-9663891 3.201674e-01 0.495 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.262105e-01 0.899 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.119234e-01 0.385 0 0
Gene expression (Transcription) R-HSA-74160 2.407320e-01 0.618 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 5.937695e-01 0.226 0 0
Developmental Biology R-HSA-1266738 4.543068e-01 0.343 0 0
RNA Polymerase II Transcription R-HSA-73857 1.921376e-01 0.716 0 0
Macroautophagy R-HSA-1632852 4.514849e-01 0.345 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.434543e-01 0.843 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.110682e-02 1.040 0 0
Selenocysteine synthesis R-HSA-2408557 4.278693e-01 0.369 0 0
Vesicle-mediated transport R-HSA-5653656 4.261171e-01 0.370 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.981870e-01 0.223 0 0
Cell junction organization R-HSA-446728 3.841084e-01 0.416 0 0
Heme signaling R-HSA-9707616 1.507240e-01 0.822 0 0
The NLRP3 inflammasome R-HSA-844456 1.059243e-01 0.975 0 0
mRNA Editing R-HSA-75072 4.760879e-01 0.322 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 4.994842e-01 0.301 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.211083e-01 0.207 0 0
Generic Transcription Pathway R-HSA-212436 2.461599e-01 0.609 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.335242e-01 0.874 0 0
Reproduction R-HSA-1474165 1.795267e-01 0.746 0 0
Deubiquitination R-HSA-5688426 4.388631e-01 0.358 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.681433e-01 0.246 0 0
Sensory processing of sound R-HSA-9659379 8.146022e-02 1.089 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.567976e-01 0.590 0 0
Signaling by NOTCH1 R-HSA-1980143 2.390763e-01 0.621 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 3.390294e-01 0.470 0 0
G-protein beta:gamma signalling R-HSA-397795 5.957172e-01 0.225 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.249695e-01 0.204 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.813466e-01 0.551 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.270779e-01 0.203 0 0
Cell-Cell communication R-HSA-1500931 2.868397e-01 0.542 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.344584e-01 0.630 0 0
Inhibition of PKR R-HSA-169131 2.344584e-01 0.630 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.403570e-01 0.619 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.434543e-01 0.843 0 0
Signaling by AXIN mutants R-HSA-4839735 1.434543e-01 0.843 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 2.894724e-01 0.538 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.139656e-01 0.383 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.139656e-01 0.383 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.139656e-01 0.383 0 0
C6 deamination of adenosine R-HSA-75102 4.139656e-01 0.383 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.139656e-01 0.383 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.969116e-01 0.706 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.969116e-01 0.706 0 0
Bicarbonate transporters R-HSA-425381 2.881956e-01 0.540 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.445327e-01 0.612 0 0
Negative regulation of FLT3 R-HSA-9706369 2.796013e-01 0.553 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.796013e-01 0.553 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.858349e-01 0.414 0 0
MET interacts with TNS proteins R-HSA-8875513 4.872627e-01 0.312 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.551222e-01 0.809 0 0
Signaling by LTK R-HSA-9842663 3.604329e-01 0.443 0 0
Co-stimulation by ICOS R-HSA-9927354 4.319197e-01 0.365 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.689698e-01 0.433 0 0
Alanine metabolism R-HSA-8964540 5.513961e-01 0.259 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.246784e-01 0.372 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.196528e-01 0.495 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.576166e-01 0.339 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.169382e-01 0.380 0 0
Ionotropic activity of kainate receptors R-HSA-451306 5.577990e-01 0.254 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.075109e-01 0.216 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.075109e-01 0.216 0 0
Suppression of autophagy R-HSA-9636569 6.075109e-01 0.216 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.075109e-01 0.216 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.951113e-01 0.225 0 0
Sodium/Calcium exchangers R-HSA-425561 5.951113e-01 0.225 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.775095e-01 0.238 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.981870e-01 0.223 0 0
Recycling pathway of L1 R-HSA-437239 6.009048e-01 0.221 0 0
Metalloprotease DUBs R-HSA-5689901 6.184702e-01 0.209 0 0
Cellular responses to stress R-HSA-2262752 2.470460e-01 0.607 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.818304e-01 0.550 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.957172e-01 0.225 0 0
MTOR signalling R-HSA-165159 5.015967e-01 0.300 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.515773e-01 0.454 0 0
FLT3 signaling in disease R-HSA-9682385 3.525731e-01 0.453 0 0
Formation of the nephric duct R-HSA-9830364 2.371280e-01 0.625 0 0
Regulation of insulin secretion R-HSA-422356 5.940699e-01 0.226 0 0
Amine ligand-binding receptors R-HSA-375280 2.636798e-01 0.579 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 9.970560e-02 1.001 0 0
Cellular responses to stimuli R-HSA-8953897 2.844908e-01 0.546 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.977711e-01 0.704 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.158709e-01 0.666 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.416428e-01 0.266 0 0
Downstream signal transduction R-HSA-186763 3.739167e-01 0.427 0 0
Glycolysis R-HSA-70171 1.677852e-01 0.775 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 5.818414e-01 0.235 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 5.818414e-01 0.235 0 0
Signaling by TGFBR3 R-HSA-9839373 5.818414e-01 0.235 0 0
Signaling by PTK6 R-HSA-8848021 3.525565e-01 0.453 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.525565e-01 0.453 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.859263e-01 0.313 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.690120e-01 0.329 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 9.864791e-02 1.006 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.319197e-01 0.365 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.180980e-01 0.286 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.318932e-01 0.274 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.415995e-01 0.355 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.184702e-01 0.209 0 0
Signaling by NTRKs R-HSA-166520 3.005824e-01 0.522 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.207960e-01 0.376 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.015967e-01 0.300 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.612596e-01 0.251 0 0
G0 and Early G1 R-HSA-1538133 1.411790e-01 0.850 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.210455e-01 0.656 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.019251e-01 0.992 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.403570e-01 0.619 0 0
Interleukin-1 processing R-HSA-448706 2.173610e-01 0.663 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.894724e-01 0.538 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.319197e-01 0.365 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.674538e-01 0.776 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.760879e-01 0.322 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.513961e-01 0.259 0 0
Protein hydroxylation R-HSA-9629569 4.284163e-01 0.368 0 0
Basigin interactions R-HSA-210991 4.576166e-01 0.339 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.180980e-01 0.286 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 5.577990e-01 0.254 0 0
LGI-ADAM interactions R-HSA-5682910 5.577990e-01 0.254 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.075109e-01 0.216 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.201100e-01 0.284 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.177891e-01 0.209 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.899133e-01 0.229 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.047439e-01 0.689 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.096020e-01 0.293 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.196235e-01 0.377 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.205930e-01 0.494 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.238487e-02 1.084 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.504091e-01 0.455 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.123486e-02 1.040 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.318932e-01 0.274 0 0
Kidney development R-HSA-9830369 4.192573e-01 0.378 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.205048e-01 0.494 0 0
Inflammasomes R-HSA-622312 3.041152e-01 0.517 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.691284e-01 0.433 0 0
RUNX2 regulates bone development R-HSA-8941326 5.125154e-01 0.290 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.504413e-01 0.346 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.295877e-01 0.887 0 0
DSCAM interactions R-HSA-376172 4.139656e-01 0.383 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.524156e-01 0.598 0 0
Synthesis of PI R-HSA-1483226 2.881956e-01 0.540 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.881956e-01 0.540 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.872627e-01 0.312 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.813466e-01 0.551 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.573438e-01 0.589 0 0
Maturation of nucleoprotein R-HSA-9683610 3.962466e-01 0.402 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.271954e-01 0.485 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.797452e-01 0.745 0 0
Sensory perception of sour taste R-HSA-9729555 5.513961e-01 0.259 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.513961e-01 0.259 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.180980e-01 0.286 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.180980e-01 0.286 0 0
Disorders of Developmental Biology R-HSA-9675151 5.318932e-01 0.274 0 0
Transport of RCbl within the body R-HSA-9758890 5.577990e-01 0.254 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.075109e-01 0.216 0 0
PTK6 Down-Regulation R-HSA-8849472 6.075109e-01 0.216 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.681433e-01 0.246 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.951113e-01 0.225 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.859688e-01 0.232 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.184702e-01 0.209 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.651404e-01 0.782 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.183098e-01 0.209 0 0
Glucose metabolism R-HSA-70326 3.048252e-01 0.516 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.215057e-01 0.207 0 0
Stimuli-sensing channels R-HSA-2672351 1.890239e-01 0.723 0 0
Signaling by ALK in cancer R-HSA-9700206 1.797452e-01 0.745 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.553900e-01 0.255 0 0
Ion channel transport R-HSA-983712 5.853954e-01 0.233 0 0
Phospholipid metabolism R-HSA-1483257 5.877933e-01 0.231 0 0
Histamine receptors R-HSA-390650 4.872627e-01 0.312 0 0
Interleukin-37 signaling R-HSA-9008059 2.102391e-01 0.677 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.176624e-01 0.929 0 0
Syndecan interactions R-HSA-3000170 3.464924e-01 0.460 0 0
Formation of the anterior neural plate R-HSA-9823739 4.659711e-01 0.332 0 0
Diseases of DNA repair R-HSA-9675135 5.818414e-01 0.235 0 0
Signaling by Interleukins R-HSA-449147 5.279663e-01 0.277 0 0
Interleukin-2 family signaling R-HSA-451927 5.981870e-01 0.223 0 0
NrCAM interactions R-HSA-447038 2.403570e-01 0.619 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.139656e-01 0.383 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.858349e-01 0.414 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.872627e-01 0.312 0 0
Interleukin-18 signaling R-HSA-9012546 4.319197e-01 0.365 0 0
Sodium/Proton exchangers R-HSA-425986 4.319197e-01 0.365 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.513961e-01 0.259 0 0
Estrogen biosynthesis R-HSA-193144 6.300113e-01 0.201 0 0
Other interleukin signaling R-HSA-449836 2.203266e-01 0.657 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 2.796013e-01 0.553 0 0
Nephrin family interactions R-HSA-373753 1.217569e-01 0.915 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.246784e-01 0.372 0 0
Interleukin-7 signaling R-HSA-1266695 5.937695e-01 0.226 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.630851e-01 0.249 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.300113e-01 0.201 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.493470e-01 0.260 0 0
Maturation of nucleoprotein R-HSA-9694631 6.215057e-01 0.207 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 5.255052e-01 0.279 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.630851e-01 0.249 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.951113e-01 0.225 0 0
Disorders of Nervous System Development R-HSA-9697154 6.300113e-01 0.201 0 0
Pervasive developmental disorders R-HSA-9005895 6.300113e-01 0.201 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.300113e-01 0.201 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.850051e-01 0.733 0 0
Interleukin-15 signaling R-HSA-8983432 3.604329e-01 0.443 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 4.576166e-01 0.339 0 0
Nephron development R-HSA-9831926 5.929756e-01 0.227 0 0
Mismatch Repair R-HSA-5358508 5.929756e-01 0.227 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 4.671846e-01 0.331 0 0
Physiological factors R-HSA-5578768 4.314986e-01 0.365 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.143327e-01 0.289 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.125154e-01 0.290 0 0
PECAM1 interactions R-HSA-210990 5.577990e-01 0.254 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.775095e-01 0.238 0 0
OAS antiviral response R-HSA-8983711 6.300113e-01 0.201 0 0
Interleukin-12 signaling R-HSA-9020591 3.354310e-01 0.474 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.314986e-01 0.365 0 0
Signaling by Leptin R-HSA-2586552 5.180980e-01 0.286 0 0
Interleukin-12 family signaling R-HSA-447115 5.176343e-01 0.286 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 5.143327e-01 0.289 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.929756e-01 0.227 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.376233e-01 0.195 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.376233e-01 0.195 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.378490e-01 0.195 0 0
HIV Transcription Initiation R-HSA-167161 6.378490e-01 0.195 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.378490e-01 0.195 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.378490e-01 0.195 0 0
IRS-mediated signalling R-HSA-112399 6.380647e-01 0.195 0 0
Influenza Infection R-HSA-168255 6.381791e-01 0.195 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.389468e-01 0.195 0 0
Signal amplification R-HSA-392518 6.391322e-01 0.194 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.391322e-01 0.194 0 0
Nuclear import of Rev protein R-HSA-180746 6.391322e-01 0.194 0 0
Ca2+ pathway R-HSA-4086398 6.401298e-01 0.194 0 0
HIV Life Cycle R-HSA-162587 6.409200e-01 0.193 0 0
Cristae formation R-HSA-8949613 6.422065e-01 0.192 0 0
Insulin processing R-HSA-264876 6.422065e-01 0.192 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.468660e-01 0.189 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.486383e-01 0.188 0 0
Creatine metabolism R-HSA-71288 6.486383e-01 0.188 0 0
Signaling by ERBB4 R-HSA-1236394 6.549526e-01 0.184 0 0
PI3K Cascade R-HSA-109704 6.552334e-01 0.184 0 0
Ub-specific processing proteases R-HSA-5689880 6.552774e-01 0.184 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.556632e-01 0.183 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.566093e-01 0.183 0 0
PDE3B signalling R-HSA-165160 6.566093e-01 0.183 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.566093e-01 0.183 0 0
PKB-mediated events R-HSA-109703 6.566093e-01 0.183 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.566093e-01 0.183 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.566093e-01 0.183 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.566093e-01 0.183 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.566093e-01 0.183 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.566093e-01 0.183 0 0
Signaling by MST1 R-HSA-8852405 6.566093e-01 0.183 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.566093e-01 0.183 0 0
Phosphorylation of Emi1 R-HSA-176417 6.566093e-01 0.183 0 0
Ceramide signalling R-HSA-193681 6.566093e-01 0.183 0 0
Formation of the Editosome R-HSA-75094 6.566093e-01 0.183 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.566093e-01 0.183 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.566093e-01 0.183 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.566093e-01 0.183 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.566093e-01 0.183 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.566093e-01 0.183 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.566093e-01 0.183 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.566093e-01 0.183 0 0
Viral mRNA Translation R-HSA-192823 6.589610e-01 0.181 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 6.597199e-01 0.181 0 0
Signalling to ERKs R-HSA-187687 6.597199e-01 0.181 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.597199e-01 0.181 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.625185e-01 0.179 0 0
Acetylcholine binding and downstream events R-HSA-181431 6.625185e-01 0.179 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.625185e-01 0.179 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 6.625185e-01 0.179 0 0
FGFR2c ligand binding and activation R-HSA-190375 6.625185e-01 0.179 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.625185e-01 0.179 0 0
FGFR1c ligand binding and activation R-HSA-190373 6.625185e-01 0.179 0 0
Frs2-mediated activation R-HSA-170968 6.625185e-01 0.179 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.625185e-01 0.179 0 0
rRNA modification in the mitochondrion R-HSA-6793080 6.625185e-01 0.179 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.625185e-01 0.179 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.625185e-01 0.179 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.625185e-01 0.179 0 0
FGFR3 mutant receptor activation R-HSA-2033514 6.625185e-01 0.179 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.625185e-01 0.179 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.667374e-01 0.176 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.694256e-01 0.174 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.694888e-01 0.174 0 0
Regulation of beta-cell development R-HSA-186712 6.706606e-01 0.173 0 0
Signaling by TGFB family members R-HSA-9006936 6.710736e-01 0.173 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.712445e-01 0.173 0 0
Mitochondrial biogenesis R-HSA-1592230 6.732115e-01 0.172 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 6.743559e-01 0.171 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.743559e-01 0.171 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.743559e-01 0.171 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.743559e-01 0.171 0 0
Signalling to RAS R-HSA-167044 6.743559e-01 0.171 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.743559e-01 0.171 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.750879e-01 0.171 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.795329e-01 0.168 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.795329e-01 0.168 0 0
FGFR2 mutant receptor activation R-HSA-1839126 6.795329e-01 0.168 0 0
GPVI-mediated activation cascade R-HSA-114604 6.795329e-01 0.168 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.829899e-01 0.166 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.862721e-01 0.164 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.866877e-01 0.163 0 0
mRNA Capping R-HSA-72086 6.866877e-01 0.163 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.866877e-01 0.163 0 0
DARPP-32 events R-HSA-180024 6.866877e-01 0.163 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.866877e-01 0.163 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.866877e-01 0.163 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.926855e-01 0.159 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.926855e-01 0.159 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.926855e-01 0.159 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.926855e-01 0.159 0 0
HDL assembly R-HSA-8963896 6.926855e-01 0.159 0 0
FGFR3c ligand binding and activation R-HSA-190372 6.926855e-01 0.159 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.926855e-01 0.159 0 0
Malate-aspartate shuttle R-HSA-9856872 6.926855e-01 0.159 0 0
Signal regulatory protein family interactions R-HSA-391160 6.926855e-01 0.159 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.965959e-01 0.157 0 0
Voltage gated Potassium channels R-HSA-1296072 6.985578e-01 0.156 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.985578e-01 0.156 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.986571e-01 0.156 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.986571e-01 0.156 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.986571e-01 0.156 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.986571e-01 0.156 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.989270e-01 0.156 0 0
STAT5 Activation R-HSA-9645135 6.995682e-01 0.155 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.995682e-01 0.155 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.995682e-01 0.155 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.995682e-01 0.155 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.995682e-01 0.155 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.995682e-01 0.155 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.995682e-01 0.155 0 0
NADPH regeneration R-HSA-389542 6.995682e-01 0.155 0 0
Nef and signal transduction R-HSA-164944 6.995682e-01 0.155 0 0
Lipid particle organization R-HSA-8964572 6.995682e-01 0.155 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.014118e-01 0.154 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 7.048727e-01 0.152 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.048727e-01 0.152 0 0
Smooth Muscle Contraction R-HSA-445355 7.048727e-01 0.152 0 0
Platelet degranulation R-HSA-114608 7.065106e-01 0.151 0 0
Platelet homeostasis R-HSA-418346 7.065662e-01 0.151 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.074078e-01 0.150 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.074078e-01 0.150 0 0
Activation of BH3-only proteins R-HSA-114452 7.074078e-01 0.150 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.074078e-01 0.150 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.097716e-01 0.149 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.097716e-01 0.149 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.097716e-01 0.149 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.129447e-01 0.147 0 0
MET promotes cell motility R-HSA-8875878 7.167873e-01 0.145 0 0
Chromosome Maintenance R-HSA-73886 7.169292e-01 0.145 0 0
Translation initiation complex formation R-HSA-72649 7.203205e-01 0.142 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.205890e-01 0.142 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.205890e-01 0.142 0 0
Translesion synthesis by REV1 R-HSA-110312 7.205890e-01 0.142 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.205890e-01 0.142 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.205890e-01 0.142 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.205890e-01 0.142 0 0
p38MAPK events R-HSA-171007 7.205890e-01 0.142 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.205890e-01 0.142 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 7.205890e-01 0.142 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 7.205890e-01 0.142 0 0
Protein methylation R-HSA-8876725 7.205890e-01 0.142 0 0
Other semaphorin interactions R-HSA-416700 7.205890e-01 0.142 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.205890e-01 0.142 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.207999e-01 0.142 0 0
FGFR2 alternative splicing R-HSA-6803529 7.215543e-01 0.142 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.215543e-01 0.142 0 0
mTORC1-mediated signalling R-HSA-166208 7.215543e-01 0.142 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.215543e-01 0.142 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.215543e-01 0.142 0 0
Signaling by KIT in disease R-HSA-9669938 7.215543e-01 0.142 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.215543e-01 0.142 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.261329e-01 0.139 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.261329e-01 0.139 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.261329e-01 0.139 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.264896e-01 0.139 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.264896e-01 0.139 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.271119e-01 0.138 0 0
Budding and maturation of HIV virion R-HSA-162588 7.271119e-01 0.138 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.271119e-01 0.138 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.271119e-01 0.138 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.271119e-01 0.138 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.302465e-01 0.137 0 0
Signaling by ALK R-HSA-201556 7.342193e-01 0.134 0 0
HDACs deacetylate histones R-HSA-3214815 7.352091e-01 0.134 0 0
Signaling by NOTCH3 R-HSA-9012852 7.352091e-01 0.134 0 0
Signaling by FGFR2 R-HSA-5654738 7.362326e-01 0.133 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.371550e-01 0.132 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.371550e-01 0.132 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.371550e-01 0.132 0 0
Disinhibition of SNARE formation R-HSA-114516 7.371550e-01 0.132 0 0
Recycling of eIF2:GDP R-HSA-72731 7.371550e-01 0.132 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.371550e-01 0.132 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.371550e-01 0.132 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.371550e-01 0.132 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.371550e-01 0.132 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.371550e-01 0.132 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.371550e-01 0.132 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.371550e-01 0.132 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.371550e-01 0.132 0 0
Glycoprotein hormones R-HSA-209822 7.371550e-01 0.132 0 0
CHL1 interactions R-HSA-447041 7.371550e-01 0.132 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.371550e-01 0.132 0 0
Maturation of replicase proteins R-HSA-9694301 7.371550e-01 0.132 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.394844e-01 0.131 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.429481e-01 0.129 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.430714e-01 0.129 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.430714e-01 0.129 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.430714e-01 0.129 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.430714e-01 0.129 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.430714e-01 0.129 0 0
Insulin receptor signalling cascade R-HSA-74751 7.439328e-01 0.128 0 0
Ion transport by P-type ATPases R-HSA-936837 7.439328e-01 0.128 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.458076e-01 0.127 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.458076e-01 0.127 0 0
Translesion synthesis by POLI R-HSA-5656121 7.463230e-01 0.127 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.463230e-01 0.127 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.463230e-01 0.127 0 0
Killing mechanisms R-HSA-9664420 7.463230e-01 0.127 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.463230e-01 0.127 0 0
Prolonged ERK activation events R-HSA-169893 7.463230e-01 0.127 0 0
Differentiation of T cells R-HSA-9945266 7.463230e-01 0.127 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.463230e-01 0.127 0 0
Regulation of BACH1 activity R-HSA-9708530 7.463230e-01 0.127 0 0
Activation of SMO R-HSA-5635838 7.463230e-01 0.127 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.463230e-01 0.127 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.463230e-01 0.127 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.463230e-01 0.127 0 0
L1CAM interactions R-HSA-373760 7.484288e-01 0.126 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.484413e-01 0.126 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 7.495365e-01 0.125 0 0
Signaling by FGFR1 R-HSA-5654736 7.495365e-01 0.125 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.499060e-01 0.125 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.499060e-01 0.125 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.508563e-01 0.124 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.522816e-01 0.124 0 0
Adipogenesis R-HSA-9843745 7.557195e-01 0.122 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.632416e-01 0.117 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.632416e-01 0.117 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.632416e-01 0.117 0 0
Complex III assembly R-HSA-9865881 7.632416e-01 0.117 0 0
Regulation of CDH1 Function R-HSA-9764561 7.633033e-01 0.117 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.635084e-01 0.117 0 0
PTEN Regulation R-HSA-6807070 7.637426e-01 0.117 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.667050e-01 0.115 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 7.667050e-01 0.115 0 0
Phase 2 - plateau phase R-HSA-5576893 7.699936e-01 0.114 0 0
Translesion synthesis by POLK R-HSA-5655862 7.699936e-01 0.114 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.699936e-01 0.114 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.699936e-01 0.114 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.699936e-01 0.114 0 0
Passive transport by Aquaporins R-HSA-432047 7.699936e-01 0.114 0 0
tRNA modification in the mitochondrion R-HSA-6787450 7.699936e-01 0.114 0 0
Synthesis of PG R-HSA-1483148 7.699936e-01 0.114 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.700413e-01 0.113 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.700413e-01 0.113 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.700413e-01 0.113 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.700413e-01 0.113 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.700413e-01 0.113 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.700413e-01 0.113 0 0
Regulation by c-FLIP R-HSA-3371378 7.700413e-01 0.113 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.700413e-01 0.113 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.700413e-01 0.113 0 0
Dimerization of procaspase-8 R-HSA-69416 7.700413e-01 0.113 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.700413e-01 0.113 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.700413e-01 0.113 0 0
Alpha-defensins R-HSA-1462054 7.700413e-01 0.113 0 0
Metabolism of RNA R-HSA-8953854 7.726409e-01 0.112 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.765123e-01 0.110 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.802334e-01 0.108 0 0
Cell-cell junction organization R-HSA-421270 7.816385e-01 0.107 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 7.817760e-01 0.107 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.821057e-01 0.107 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.821057e-01 0.107 0 0
Nucleotide Excision Repair R-HSA-5696398 7.821258e-01 0.107 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.821258e-01 0.107 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.850223e-01 0.105 0 0
Extension of Telomeres R-HSA-180786 7.891681e-01 0.103 0 0
Triglyceride metabolism R-HSA-8979227 7.891681e-01 0.103 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.916498e-01 0.101 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.917141e-01 0.101 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.917141e-01 0.101 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.917141e-01 0.101 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.917141e-01 0.101 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.917141e-01 0.101 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.917141e-01 0.101 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.943606e-01 0.100 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.960057e-01 0.099 0 0
Dual Incision in GG-NER R-HSA-5696400 7.960057e-01 0.099 0 0
Mitophagy R-HSA-5205647 7.960057e-01 0.099 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.960057e-01 0.099 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.960829e-01 0.099 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.988147e-01 0.098 0 0
Interleukin-21 signaling R-HSA-9020958 7.988147e-01 0.098 0 0
CASP8 activity is inhibited R-HSA-5218900 7.988147e-01 0.098 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.988147e-01 0.098 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.988147e-01 0.098 0 0
ARMS-mediated activation R-HSA-170984 7.988147e-01 0.098 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.988147e-01 0.098 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.988147e-01 0.098 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 7.988147e-01 0.098 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.988147e-01 0.098 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.988147e-01 0.098 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.997101e-01 0.097 0 0
Myogenesis R-HSA-525793 7.997101e-01 0.097 0 0
Synthesis of DNA R-HSA-69239 8.008735e-01 0.096 0 0
GABA receptor activation R-HSA-977443 8.012775e-01 0.096 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.086092e-01 0.092 0 0
Orc1 removal from chromatin R-HSA-68949 8.106152e-01 0.091 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.106152e-01 0.091 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.106152e-01 0.091 0 0
Oncogene Induced Senescence R-HSA-2559585 8.108524e-01 0.091 0 0
GAB1 signalosome R-HSA-180292 8.116019e-01 0.091 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.116019e-01 0.091 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.116019e-01 0.091 0 0
Tie2 Signaling R-HSA-210993 8.116019e-01 0.091 0 0
Platelet sensitization by LDL R-HSA-432142 8.116019e-01 0.091 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 8.116019e-01 0.091 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.120446e-01 0.090 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.128487e-01 0.090 0 0
Aquaporin-mediated transport R-HSA-445717 8.128487e-01 0.090 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.161057e-01 0.088 0 0
Packaging Of Telomere Ends R-HSA-171306 8.161057e-01 0.088 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.161057e-01 0.088 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.161057e-01 0.088 0 0
Host Interactions of HIV factors R-HSA-162909 8.200901e-01 0.086 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.224728e-01 0.085 0 0
DAP12 interactions R-HSA-2172127 8.224728e-01 0.085 0 0
Signaling by Hedgehog R-HSA-5358351 8.224816e-01 0.085 0 0
Signaling by PDGF R-HSA-186797 8.238914e-01 0.084 0 0
Binding and entry of HIV virion R-HSA-173107 8.239892e-01 0.084 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.239892e-01 0.084 0 0
DNA replication initiation R-HSA-68952 8.239892e-01 0.084 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.239892e-01 0.084 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.239892e-01 0.084 0 0
Arachidonate production from DAG R-HSA-426048 8.239892e-01 0.084 0 0
Pexophagy R-HSA-9664873 8.239892e-01 0.084 0 0
Maturation of spike protein R-HSA-9683686 8.239892e-01 0.084 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.239892e-01 0.084 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.239892e-01 0.084 0 0
Sperm Motility And Taxes R-HSA-1300642 8.239892e-01 0.084 0 0
Peptide hormone biosynthesis R-HSA-209952 8.239892e-01 0.084 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.239892e-01 0.084 0 0
Serotonin receptors R-HSA-390666 8.239892e-01 0.084 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.261596e-01 0.083 0 0
Hedgehog 'on' state R-HSA-5632684 8.261596e-01 0.083 0 0
Adherens junctions interactions R-HSA-418990 8.272549e-01 0.082 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.289725e-01 0.081 0 0
Regulation of signaling by CBL R-HSA-912631 8.297755e-01 0.081 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.297755e-01 0.081 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 8.297755e-01 0.081 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.313465e-01 0.080 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.313465e-01 0.080 0 0
Telomere Extension By Telomerase R-HSA-171319 8.313465e-01 0.080 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.313465e-01 0.080 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.313465e-01 0.080 0 0
Pyroptosis R-HSA-5620971 8.313465e-01 0.080 0 0
HIV Infection R-HSA-162906 8.321862e-01 0.080 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.344165e-01 0.079 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.345952e-01 0.079 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.345952e-01 0.079 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.350101e-01 0.078 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.355025e-01 0.078 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.360266e-01 0.078 0 0
Cleavage of the damaged purine R-HSA-110331 8.378904e-01 0.077 0 0
NCAM1 interactions R-HSA-419037 8.378904e-01 0.077 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.411972e-01 0.075 0 0
Inositol phosphate metabolism R-HSA-1483249 8.425666e-01 0.074 0 0
DNA methylation R-HSA-5334118 8.454885e-01 0.073 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.454885e-01 0.073 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.454885e-01 0.073 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.460149e-01 0.073 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.460149e-01 0.073 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.460149e-01 0.073 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.460149e-01 0.073 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.460149e-01 0.073 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.460149e-01 0.073 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.460149e-01 0.073 0 0
Prostanoid ligand receptors R-HSA-391908 8.460149e-01 0.073 0 0
Interleukin-2 signaling R-HSA-9020558 8.460149e-01 0.073 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.463524e-01 0.072 0 0
Negative regulation of MET activity R-HSA-6807004 8.463524e-01 0.072 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.463524e-01 0.072 0 0
Interferon Signaling R-HSA-913531 8.488112e-01 0.071 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.501480e-01 0.071 0 0
Depurination R-HSA-73927 8.501480e-01 0.071 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.534398e-01 0.069 0 0
Signaling by NOTCH4 R-HSA-9013694 8.544334e-01 0.068 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.545702e-01 0.068 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 8.545702e-01 0.068 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.568069e-01 0.067 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.592249e-01 0.066 0 0
Signaling by FGFR R-HSA-190236 8.593981e-01 0.066 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.614475e-01 0.065 0 0
ERK/MAPK targets R-HSA-198753 8.614475e-01 0.065 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.614475e-01 0.065 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.630118e-01 0.064 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.652855e-01 0.063 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.652855e-01 0.063 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.652855e-01 0.063 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.652855e-01 0.063 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.652855e-01 0.063 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.652855e-01 0.063 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.652855e-01 0.063 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.652855e-01 0.063 0 0
Integration of provirus R-HSA-162592 8.652855e-01 0.063 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.662227e-01 0.062 0 0
Interleukin-1 family signaling R-HSA-446652 8.662227e-01 0.062 0 0
Intraflagellar transport R-HSA-5620924 8.669442e-01 0.062 0 0
GPER1 signaling R-HSA-9634597 8.669442e-01 0.062 0 0
Metal ion SLC transporters R-HSA-425410 8.669442e-01 0.062 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.707044e-01 0.060 0 0
UCH proteinases R-HSA-5689603 8.711429e-01 0.060 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.714912e-01 0.060 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.723151e-01 0.059 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.723151e-01 0.059 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.723151e-01 0.059 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.723151e-01 0.059 0 0
Dual incision in TC-NER R-HSA-6782135 8.731937e-01 0.059 0 0
Signaling by PDGFR in disease R-HSA-9671555 8.751721e-01 0.058 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.751721e-01 0.058 0 0
Assembly Of The HIV Virion R-HSA-175474 8.751721e-01 0.058 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.753774e-01 0.058 0 0
DNA Damage Bypass R-HSA-73893 8.764693e-01 0.057 0 0
Degradation of CDH1 R-HSA-9766229 8.764693e-01 0.057 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.777895e-01 0.057 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.794503e-01 0.056 0 0
Regulated Necrosis R-HSA-5218859 8.797310e-01 0.056 0 0
DNA Repair R-HSA-73894 8.816516e-01 0.055 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.817982e-01 0.055 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.821454e-01 0.054 0 0
MET activates RAS signaling R-HSA-8851805 8.821454e-01 0.054 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.821454e-01 0.054 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.821454e-01 0.054 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.821454e-01 0.054 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.821454e-01 0.054 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.821454e-01 0.054 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.821454e-01 0.054 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.821454e-01 0.054 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.821454e-01 0.054 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.822968e-01 0.054 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.822968e-01 0.054 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.834353e-01 0.054 0 0
Neutrophil degranulation R-HSA-6798695 8.844182e-01 0.053 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.859037e-01 0.053 0 0
Regulation of endogenous retroelements R-HSA-9842860 8.868899e-01 0.052 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.876326e-01 0.052 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.876326e-01 0.052 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 8.876326e-01 0.052 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 8.876326e-01 0.052 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.897787e-01 0.051 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.897787e-01 0.051 1 1
Degradation of GLI1 by the proteasome R-HSA-5610780 8.915924e-01 0.050 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.915924e-01 0.050 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.915924e-01 0.050 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.915924e-01 0.050 0 0
Translation of Structural Proteins R-HSA-9683701 8.915924e-01 0.050 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.924873e-01 0.049 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.932330e-01 0.049 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.937857e-01 0.049 0 0
Meiotic recombination R-HSA-912446 8.937857e-01 0.049 0 0
Chylomicron remodeling R-HSA-8963901 8.968962e-01 0.047 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.968962e-01 0.047 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.968962e-01 0.047 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.968962e-01 0.047 0 0
Processing of SMDT1 R-HSA-8949664 8.968962e-01 0.047 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.968962e-01 0.047 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 8.968962e-01 0.047 0 0
Interleukin-6 signaling R-HSA-1059683 8.968962e-01 0.047 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.968962e-01 0.047 0 0
MAP kinase activation R-HSA-450294 8.973557e-01 0.047 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.989304e-01 0.046 0 0
Formation of the ureteric bud R-HSA-9830674 8.989304e-01 0.046 0 0
Carnitine shuttle R-HSA-200425 8.989304e-01 0.046 0 0
Growth hormone receptor signaling R-HSA-982772 8.989304e-01 0.046 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.998538e-01 0.046 0 0
Signaling by MET R-HSA-6806834 8.998538e-01 0.046 0 0
Activation of GABAB receptors R-HSA-991365 9.002380e-01 0.046 0 0
GABA B receptor activation R-HSA-977444 9.002380e-01 0.046 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.015947e-01 0.045 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.015947e-01 0.045 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.016290e-01 0.045 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.017111e-01 0.045 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.017111e-01 0.045 0 0
Heme degradation R-HSA-189483 9.017111e-01 0.045 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.017111e-01 0.045 0 0
Interferon gamma signaling R-HSA-877300 9.025279e-01 0.045 0 0
Mitochondrial protein import R-HSA-1268020 9.044822e-01 0.044 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.044822e-01 0.044 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.048531e-01 0.043 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.070057e-01 0.042 0 0
Defective pyroptosis R-HSA-9710421 9.082690e-01 0.042 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.082690e-01 0.042 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.089633e-01 0.041 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.091613e-01 0.041 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.091613e-01 0.041 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.091613e-01 0.041 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.091613e-01 0.041 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.098014e-01 0.041 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.098014e-01 0.041 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.098014e-01 0.041 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.098014e-01 0.041 0 0
Ciprofloxacin ADME R-HSA-9793528 9.098014e-01 0.041 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.098014e-01 0.041 0 0
Zinc transporters R-HSA-435354 9.098014e-01 0.041 0 0
P2Y receptors R-HSA-417957 9.098014e-01 0.041 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.098014e-01 0.041 0 0
Telomere Maintenance R-HSA-157579 9.100385e-01 0.041 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.104492e-01 0.041 0 0
Signaling by NOTCH2 R-HSA-1980145 9.104492e-01 0.041 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.104492e-01 0.041 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.104492e-01 0.041 0 0
Downstream TCR signaling R-HSA-202424 9.107342e-01 0.041 0 0
Base Excision Repair R-HSA-73884 9.107342e-01 0.041 0 0
DNA Replication R-HSA-69306 9.141968e-01 0.039 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.153002e-01 0.038 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.153002e-01 0.038 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.153002e-01 0.038 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.184154e-01 0.037 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.184154e-01 0.037 0 0
G protein gated Potassium channels R-HSA-1296059 9.184154e-01 0.037 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.184154e-01 0.037 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.184154e-01 0.037 0 0
Laminin interactions R-HSA-3000157 9.184154e-01 0.037 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.184757e-01 0.037 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.184757e-01 0.037 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.195853e-01 0.036 0 0
Ribosome-associated quality control R-HSA-9948299 9.206742e-01 0.036 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.210920e-01 0.036 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 9.210920e-01 0.036 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.210920e-01 0.036 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 9.210920e-01 0.036 0 0
Signaling by Activin R-HSA-1502540 9.210920e-01 0.036 0 0
Events associated with phagocytolytic activity of PMN cells R-HSA-8941413 9.210920e-01 0.036 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.210920e-01 0.036 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.210920e-01 0.036 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.210920e-01 0.036 0 0
Parasitic Infection Pathways R-HSA-9824443 9.212575e-01 0.036 0 0
Leishmania infection R-HSA-9658195 9.212575e-01 0.036 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.222065e-01 0.035 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.229712e-01 0.035 0 0
Signaling by NOTCH R-HSA-157118 9.250564e-01 0.034 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.254066e-01 0.034 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.254066e-01 0.034 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.258401e-01 0.033 0 0
Signaling by Insulin receptor R-HSA-74752 9.262080e-01 0.033 0 0
MET activates PTK2 signaling R-HSA-8874081 9.267768e-01 0.033 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.267768e-01 0.033 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.267768e-01 0.033 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.267768e-01 0.033 0 0
Abacavir ADME R-HSA-2161522 9.267768e-01 0.033 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.267768e-01 0.033 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.281650e-01 0.032 0 0
Circadian clock R-HSA-9909396 9.282793e-01 0.032 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.290188e-01 0.032 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.290188e-01 0.032 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.290188e-01 0.032 0 0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 9.309699e-01 0.031 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.309699e-01 0.031 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.309699e-01 0.031 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.309699e-01 0.031 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.309699e-01 0.031 0 0
Fructose catabolism R-HSA-70350 9.309699e-01 0.031 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.309699e-01 0.031 0 0
Atorvastatin ADME R-HSA-9754706 9.309699e-01 0.031 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.322949e-01 0.030 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.325892e-01 0.030 0 0
Degradation of DVL R-HSA-4641258 9.325892e-01 0.030 0 0
Cellular response to starvation R-HSA-9711097 9.331598e-01 0.030 0 0
Hemostasis R-HSA-109582 9.340579e-01 0.030 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.343239e-01 0.030 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.343239e-01 0.030 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.349307e-01 0.029 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.349307e-01 0.029 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.371394e-01 0.028 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.388753e-01 0.027 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.396117e-01 0.027 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.396117e-01 0.027 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.396117e-01 0.027 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.396117e-01 0.027 0 0
Coenzyme A biosynthesis R-HSA-196783 9.396117e-01 0.027 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.396117e-01 0.027 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.398505e-01 0.027 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.398526e-01 0.027 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.398526e-01 0.027 0 0
Gluconeogenesis R-HSA-70263 9.403922e-01 0.027 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.411296e-01 0.026 0 0
Pyrimidine salvage R-HSA-73614 9.411296e-01 0.026 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.436727e-01 0.025 0 0
Stabilization of p53 R-HSA-69541 9.444190e-01 0.025 0 0
Gap junction trafficking and regulation R-HSA-157858 9.454328e-01 0.024 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.456778e-01 0.024 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.471721e-01 0.024 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.471721e-01 0.024 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.471721e-01 0.024 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.471721e-01 0.024 0 0
Interleukin-17 signaling R-HSA-448424 9.475989e-01 0.023 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.497618e-01 0.022 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.497618e-01 0.022 0 0
Selenoamino acid metabolism R-HSA-2408522 9.511203e-01 0.022 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.512416e-01 0.022 0 0
Neurotransmitter release cycle R-HSA-112310 9.524480e-01 0.021 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.527806e-01 0.021 0 0
Neurotransmitter clearance R-HSA-112311 9.527806e-01 0.021 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.537864e-01 0.021 0 0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 9.537864e-01 0.021 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.537864e-01 0.021 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.537864e-01 0.021 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.537864e-01 0.021 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.537864e-01 0.021 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.537864e-01 0.021 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.537864e-01 0.021 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.537864e-01 0.021 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.539114e-01 0.020 0 0
Maturation of spike protein R-HSA-9694548 9.542950e-01 0.020 0 0
The phototransduction cascade R-HSA-2514856 9.543619e-01 0.020 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.557141e-01 0.020 0 0
tRNA processing in the nucleus R-HSA-6784531 9.560910e-01 0.020 0 0
Leishmania phagocytosis R-HSA-9664417 9.568441e-01 0.019 0 0
Parasite infection R-HSA-9664407 9.568441e-01 0.019 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.568441e-01 0.019 0 0
Cargo concentration in the ER R-HSA-5694530 9.577451e-01 0.019 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.584004e-01 0.018 0 0
IRE1alpha activates chaperones R-HSA-381070 9.587780e-01 0.018 0 0
Translesion Synthesis by POLH R-HSA-110320 9.595728e-01 0.018 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.595728e-01 0.018 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.595728e-01 0.018 0 0
Diseases of hemostasis R-HSA-9671793 9.595728e-01 0.018 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.595728e-01 0.018 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.595728e-01 0.018 0 0
Adaptive Immune System R-HSA-1280218 9.610799e-01 0.017 0 0
Potential therapeutics for SARS R-HSA-9679191 9.611560e-01 0.017 0 0
Peptide hormone metabolism R-HSA-2980736 9.617985e-01 0.017 0 0
Interleukin-1 signaling R-HSA-9020702 9.622611e-01 0.017 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.625099e-01 0.017 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.625099e-01 0.017 0 0
Depyrimidination R-HSA-73928 9.625099e-01 0.017 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.638445e-01 0.016 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.646351e-01 0.016 0 0
Signaling by NODAL R-HSA-1181150 9.646351e-01 0.016 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.646351e-01 0.016 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.646351e-01 0.016 0 0
Pregnenolone biosynthesis R-HSA-196108 9.646351e-01 0.016 0 0
Signal transduction by L1 R-HSA-445144 9.646351e-01 0.016 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.646351e-01 0.016 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.652557e-01 0.015 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.652557e-01 0.015 0 0
Cellular response to hypoxia R-HSA-1234174 9.659586e-01 0.015 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.660759e-01 0.015 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.662146e-01 0.015 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.662146e-01 0.015 0 0
rRNA processing R-HSA-72312 9.668312e-01 0.015 0 0
G-protein activation R-HSA-202040 9.690637e-01 0.014 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.690637e-01 0.014 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.690637e-01 0.014 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.690637e-01 0.014 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.690637e-01 0.014 0 0
Phenylalanine metabolism R-HSA-8964208 9.690637e-01 0.014 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.690637e-01 0.014 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.690637e-01 0.014 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.690637e-01 0.014 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.698113e-01 0.013 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.698113e-01 0.013 0 0
Translation of Structural Proteins R-HSA-9694635 9.700008e-01 0.013 0 0
Co-inhibition by PD-1 R-HSA-389948 9.712783e-01 0.013 0 0
Toll-like Receptor Cascades R-HSA-168898 9.713928e-01 0.013 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.722690e-01 0.012 0 0
Cholesterol biosynthesis R-HSA-191273 9.723599e-01 0.012 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.729379e-01 0.012 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.729379e-01 0.012 0 0
Glutathione synthesis and recycling R-HSA-174403 9.729379e-01 0.012 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.730373e-01 0.012 0 0
Hyaluronan metabolism R-HSA-2142845 9.730373e-01 0.012 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.745468e-01 0.011 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.759290e-01 0.011 0 0
PERK regulates gene expression R-HSA-381042 9.759290e-01 0.011 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.759290e-01 0.011 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.763272e-01 0.010 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.763272e-01 0.010 0 0
Fructose metabolism R-HSA-5652084 9.763272e-01 0.010 0 0
Ethanol oxidation R-HSA-71384 9.763272e-01 0.010 0 0
Cellular hexose transport R-HSA-189200 9.763272e-01 0.010 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.781982e-01 0.010 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.785196e-01 0.009 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.785196e-01 0.009 0 0
RNA Polymerase III Transcription R-HSA-74158 9.785196e-01 0.009 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.792922e-01 0.009 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.792922e-01 0.009 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.792922e-01 0.009 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.792922e-01 0.009 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.792922e-01 0.009 0 0
Biosynthesis of maresins R-HSA-9018682 9.792922e-01 0.009 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.808390e-01 0.008 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.808390e-01 0.008 0 0
Degradation of AXIN R-HSA-4641257 9.808390e-01 0.008 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.808390e-01 0.008 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.818859e-01 0.008 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.818859e-01 0.008 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.818859e-01 0.008 0 0
Interleukin-6 family signaling R-HSA-6783589 9.818859e-01 0.008 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.819726e-01 0.008 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.829145e-01 0.007 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.841549e-01 0.007 0 0
Hyaluronan degradation R-HSA-2160916 9.841549e-01 0.007 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.841549e-01 0.007 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.841549e-01 0.007 0 0
Fertilization R-HSA-1187000 9.841549e-01 0.007 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.841549e-01 0.007 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.843016e-01 0.007 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.845985e-01 0.007 0 0
Pentose phosphate pathway R-HSA-71336 9.847709e-01 0.007 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.847709e-01 0.007 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.847709e-01 0.007 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.850371e-01 0.007 0 0
Collagen formation R-HSA-1474290 9.850391e-01 0.007 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.859033e-01 0.006 0 0
Iron uptake and transport R-HSA-917937 9.859328e-01 0.006 0 0
Urea cycle R-HSA-70635 9.861398e-01 0.006 0 0
Sphingolipid catabolism R-HSA-9845614 9.861398e-01 0.006 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.863164e-01 0.006 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.864305e-01 0.006 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.864305e-01 0.006 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.864305e-01 0.006 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.864305e-01 0.006 0 0
Glycogen metabolism R-HSA-8982491 9.864305e-01 0.006 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.865213e-01 0.006 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.865213e-01 0.006 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.878762e-01 0.005 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.878762e-01 0.005 0 0
Triglyceride biosynthesis R-HSA-75109 9.878762e-01 0.005 0 0
Synthesis of PE R-HSA-1483213 9.878762e-01 0.005 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.878762e-01 0.005 0 0
Signaling by BMP R-HSA-201451 9.878762e-01 0.005 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.878762e-01 0.005 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.879133e-01 0.005 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.879133e-01 0.005 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.881432e-01 0.005 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.891978e-01 0.005 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.892378e-01 0.005 0 0
PCP/CE pathway R-HSA-4086400 9.893104e-01 0.005 0 0
Prednisone ADME R-HSA-9757110 9.893951e-01 0.005 0 0
Insulin receptor recycling R-HSA-77387 9.893951e-01 0.005 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.893951e-01 0.005 0 0
Gene Silencing by RNA R-HSA-211000 9.895646e-01 0.005 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.899235e-01 0.004 0 0
G alpha (q) signalling events R-HSA-416476 9.899333e-01 0.004 0 0
G alpha (z) signalling events R-HSA-418597 9.901725e-01 0.004 0 0
Paracetamol ADME R-HSA-9753281 9.901725e-01 0.004 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.904201e-01 0.004 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.904201e-01 0.004 0 0
Thyroxine biosynthesis R-HSA-209968 9.907238e-01 0.004 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.907238e-01 0.004 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.907238e-01 0.004 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.907238e-01 0.004 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.907238e-01 0.004 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.914753e-01 0.004 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.915510e-01 0.004 0 0
ABC-family proteins mediated transport R-HSA-382556 9.916492e-01 0.004 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.918037e-01 0.004 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.918861e-01 0.004 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.918861e-01 0.004 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.924164e-01 0.003 0 0
Gap junction trafficking R-HSA-190828 9.924164e-01 0.003 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.924164e-01 0.003 0 0
Surfactant metabolism R-HSA-5683826 9.924164e-01 0.003 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.925107e-01 0.003 0 0
SLC transporter disorders R-HSA-5619102 9.927603e-01 0.003 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.929028e-01 0.003 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.929028e-01 0.003 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.929028e-01 0.003 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.929028e-01 0.003 0 0
Protein folding R-HSA-391251 9.930169e-01 0.003 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.930169e-01 0.003 0 0
HCMV Early Events R-HSA-9609690 9.930620e-01 0.003 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.932557e-01 0.003 0 0
Somitogenesis R-HSA-9824272 9.932557e-01 0.003 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.935863e-01 0.003 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.936008e-01 0.003 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.937922e-01 0.003 0 0
tRNA Aminoacylation R-HSA-379724 9.942407e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.942407e-01 0.003 0 0
GPCR downstream signalling R-HSA-388396 9.944982e-01 0.002 0 0
RSV-host interactions R-HSA-9833110 9.945605e-01 0.002 0 0
Recycling of bile acids and salts R-HSA-159418 9.945702e-01 0.002 0 0
Synthesis of PC R-HSA-1483191 9.946703e-01 0.002 0 0
G alpha (s) signalling events R-HSA-418555 9.948857e-01 0.002 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.950146e-01 0.002 0 0
Protein localization R-HSA-9609507 9.953347e-01 0.002 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.953607e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.954146e-01 0.002 0 0
Protein ubiquitination R-HSA-8852135 9.954684e-01 0.002 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.954684e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.958389e-01 0.002 0 0
eNOS activation R-HSA-203615 9.958459e-01 0.002 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.958459e-01 0.002 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.958459e-01 0.002 0 0
RA biosynthesis pathway R-HSA-5365859 9.958459e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.958459e-01 0.002 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.958459e-01 0.002 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.961657e-01 0.002 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.963666e-01 0.002 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.963666e-01 0.002 0 0
Regulation of Apoptosis R-HSA-169911 9.963666e-01 0.002 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.963666e-01 0.002 0 0
ER-Phagosome pathway R-HSA-1236974 9.965655e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.966624e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.966624e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.968221e-01 0.001 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.968221e-01 0.001 0 0
Immune System R-HSA-168256 9.970346e-01 0.001 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.972204e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.972204e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.972204e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.973135e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.973135e-01 0.001 0 0
tRNA processing R-HSA-72306 9.973718e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.975937e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.977864e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.978737e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.978737e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.980713e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.980713e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.980910e-01 0.001 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.981403e-01 0.001 0 0
Tryptophan catabolism R-HSA-71240 9.981403e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.982228e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.982740e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.982740e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.982891e-01 0.001 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.983735e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.983735e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.983813e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.983813e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.984557e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.984871e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.985774e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.985774e-01 0.001 0 0
Mitochondrial translation elongation R-HSA-5389840 9.985829e-01 0.001 0 0
HCMV Infection R-HSA-9609646 9.987199e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.988400e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.988400e-01 0.001 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.988683e-01 0.000 0 0
Defensins R-HSA-1461973 9.989118e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.990010e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.990010e-01 0.000 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.990131e-01 0.000 0 0
Proteasome assembly R-HSA-9907900 9.990483e-01 0.000 0 0
SARS-CoV Infections R-HSA-9679506 9.990896e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.991677e-01 0.000 0 0
RNA Polymerase I Transcription R-HSA-73864 9.992122e-01 0.000 0 0
Integrin cell surface interactions R-HSA-216083 9.992122e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.992721e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.993002e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.993312e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.993634e-01 0.000 0 0
HCMV Late Events R-HSA-9610379 9.993962e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.994392e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.994432e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.995131e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.995735e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.996093e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.996247e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.996276e-01 0.000 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.996276e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.996590e-01 0.000 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.996743e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.997046e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997046e-01 0.000 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.997152e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.997152e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.997591e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.997752e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.998095e-01 0.000 0 0
Digestion R-HSA-8935690 9.998095e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998522e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.998641e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.998651e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.998651e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.998726e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.998726e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.998741e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.998886e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.998886e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.998897e-01 0.000 0 0
Neddylation R-HSA-8951664 9.999004e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999026e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999139e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999255e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999255e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999349e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999349e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999430e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999565e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999632e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999639e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999709e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999777e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999805e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999805e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999838e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999862e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999881e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999883e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999894e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999901e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999906e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999909e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999911e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999934e-01 0.000 0 0
Translation R-HSA-72766 9.999949e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999956e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999963e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999967e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999970e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999971e-01 0.000 1 0
Extracellular matrix organization R-HSA-1474244 9.999973e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999977e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999982e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999986e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999990e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999990e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999991e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999993e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999994e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999996e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999996e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999998e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999998e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999999e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.289968e-12 11.889 0 0
Cell Cycle, Mitotic R-HSA-69278 1.012535e-11 10.995 0 0
Cell Cycle Checkpoints R-HSA-69620 3.163281e-11 10.500 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.960321e-11 10.002 0 0
M Phase R-HSA-68886 1.316043e-10 9.881 0 0
Interleukin-12 signaling R-HSA-9020591 6.283513e-10 9.202 0 0
Axon guidance R-HSA-422475 1.664506e-09 8.779 0 0
Nervous system development R-HSA-9675108 5.723656e-09 8.242 0 0
Signaling by ROBO receptors R-HSA-376176 1.242877e-08 7.906 0 0
Interleukin-12 family signaling R-HSA-447115 1.320192e-08 7.879 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.500090e-08 7.824 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.922870e-08 7.716 0 0
Cellular Senescence R-HSA-2559583 1.877351e-08 7.726 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.307984e-08 7.366 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.307984e-08 7.366 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.076010e-08 7.294 0 0
Metabolism of RNA R-HSA-8953854 5.334728e-08 7.273 0 0
Apoptotic execution phase R-HSA-75153 1.482196e-07 6.829 0 0
Cellular responses to stress R-HSA-2262752 1.451285e-07 6.838 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.801453e-07 6.744 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.033330e-07 6.518 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.601500e-07 6.337 0 0
Nucleosome assembly R-HSA-774815 4.601500e-07 6.337 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.168024e-07 6.380 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.343123e-07 6.362 0 0
Peptide chain elongation R-HSA-156902 5.907674e-07 6.229 0 0
Mitotic Prophase R-HSA-68875 7.095727e-07 6.149 0 0
Chromatin organization R-HSA-4839726 7.997232e-07 6.097 0 0
Cellular responses to stimuli R-HSA-8953897 8.394353e-07 6.076 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.020138e-06 5.991 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.020138e-06 5.991 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.047140e-06 5.980 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.047140e-06 5.980 0 0
Cell-Cell communication R-HSA-1500931 9.590331e-07 6.018 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.074690e-06 5.969 0 0
Mitotic Prometaphase R-HSA-68877 1.582000e-06 5.801 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.675695e-06 5.776 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.675695e-06 5.776 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.764759e-06 5.753 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.784188e-06 5.749 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.814500e-06 5.741 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.825320e-06 5.739 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.214221e-06 5.655 0 0
Ribosome-associated quality control R-HSA-9948299 2.474545e-06 5.607 0 0
mRNA Splicing R-HSA-72172 2.862209e-06 5.543 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.901913e-06 5.537 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.149153e-06 5.502 0 0
Chromatin modifying enzymes R-HSA-3247509 3.418811e-06 5.466 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.010452e-06 5.397 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.104853e-06 5.387 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.270643e-06 5.370 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.512025e-06 5.346 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.328748e-06 5.273 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.606712e-06 5.251 0 0
HDACs deacetylate histones R-HSA-3214815 5.951354e-06 5.225 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.266359e-06 5.203 0 0
G2/M Checkpoints R-HSA-69481 6.285905e-06 5.202 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 8.717022e-06 5.060 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.824449e-06 5.054 0 0
Mitotic Anaphase R-HSA-68882 1.053439e-05 4.977 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.167827e-05 4.933 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.280821e-05 4.893 0 0
Separation of Sister Chromatids R-HSA-2467813 1.412423e-05 4.850 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.509935e-05 4.821 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.551754e-05 4.809 0 0
Defective pyroptosis R-HSA-9710421 1.575055e-05 4.803 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.752343e-05 4.756 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.755630e-05 4.756 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.052235e-05 4.688 0 0
DNA Double Strand Break Response R-HSA-5693606 2.226581e-05 4.652 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.464107e-05 4.608 0 0
Eukaryotic Translation Termination R-HSA-72764 2.399238e-05 4.620 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.375519e-05 4.624 0 0
Signal Transduction R-HSA-162582 2.573933e-05 4.589 0 0
Cell junction organization R-HSA-446728 2.742937e-05 4.562 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.990525e-05 4.524 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.019240e-05 4.396 0 0
Meiotic synapsis R-HSA-1221632 4.323444e-05 4.364 0 0
Diseases of programmed cell death R-HSA-9645723 4.235624e-05 4.373 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.634547e-05 4.334 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.027532e-05 4.299 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.587627e-05 4.253 0 0
Selenocysteine synthesis R-HSA-2408557 5.846040e-05 4.233 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.658600e-05 4.177 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.731450e-05 4.172 0 0
Viral mRNA Translation R-HSA-192823 7.735352e-05 4.112 0 0
Cellular response to starvation R-HSA-9711097 7.766967e-05 4.110 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.638311e-05 4.064 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.506157e-05 4.022 0 0
Deubiquitination R-HSA-5688426 9.895057e-05 4.005 0 0
Adherens junctions interactions R-HSA-418990 1.075850e-04 3.968 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.123561e-04 3.949 0 0
Packaging Of Telomere Ends R-HSA-171306 1.215958e-04 3.915 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.225089e-04 3.912 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.316675e-04 3.881 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.548970e-04 3.810 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.611175e-04 3.793 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.658134e-04 3.780 0 0
Influenza Infection R-HSA-168255 1.665082e-04 3.779 0 0
Ub-specific processing proteases R-HSA-5689880 1.900830e-04 3.721 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.998866e-04 3.699 0 0
DNA methylation R-HSA-5334118 2.071439e-04 3.684 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.084798e-04 3.681 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.317944e-04 3.635 0 0
Apoptosis R-HSA-109581 2.474278e-04 3.607 0 0
Cell-cell junction organization R-HSA-421270 2.497690e-04 3.602 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.062622e-04 3.514 0 0
Homology Directed Repair R-HSA-5693538 3.159103e-04 3.500 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.392192e-04 3.470 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.392192e-04 3.470 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.392192e-04 3.470 0 0
Signaling by RAS mutants R-HSA-6802949 3.392192e-04 3.470 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.527621e-04 3.453 0 0
Signaling by ALK in cancer R-HSA-9700206 3.527621e-04 3.453 0 0
rRNA processing R-HSA-72312 3.511459e-04 3.455 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.341796e-04 3.476 0 0
Meiosis R-HSA-1500620 4.085554e-04 3.389 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.286739e-04 3.368 0 0
Chromosome Maintenance R-HSA-73886 4.425512e-04 3.354 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.472780e-04 3.349 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.955511e-04 3.305 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.653337e-04 3.332 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 4.720144e-04 3.326 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.370070e-04 3.270 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.985898e-04 3.223 0 0
G2/M Transition R-HSA-69275 6.187778e-04 3.208 0 0
Protein ubiquitination R-HSA-8852135 6.401628e-04 3.194 0 0
Striated Muscle Contraction R-HSA-390522 6.674749e-04 3.176 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.729303e-04 3.172 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.323218e-04 3.135 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.865764e-04 3.104 0 0
Meiotic recombination R-HSA-912446 8.264984e-04 3.083 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.234965e-04 3.084 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.504295e-04 3.070 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 8.725839e-04 3.059 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.238046e-04 3.034 0 0
Cellular response to heat stress R-HSA-3371556 9.516101e-04 3.022 0 0
RNA Polymerase I Transcription R-HSA-73864 9.637868e-04 3.016 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.144256e-03 2.941 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.155177e-03 2.937 0 0
EPH-Ephrin signaling R-HSA-2682334 1.277135e-03 2.894 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.310951e-03 2.882 0 0
Translation initiation complex formation R-HSA-72649 1.338268e-03 2.873 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.484201e-03 2.829 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.484201e-03 2.829 0 0
Cleavage of the damaged purine R-HSA-110331 1.484201e-03 2.829 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.497559e-03 2.825 0 0
Muscle contraction R-HSA-397014 1.526194e-03 2.816 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.605574e-03 2.794 0 0
Depurination R-HSA-73927 1.783509e-03 2.749 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.791215e-03 2.747 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.866249e-03 2.729 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.918027e-03 2.717 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.918027e-03 2.717 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.035151e-03 2.691 0 0
Regulation of CDH1 Function R-HSA-9764561 2.093090e-03 2.679 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.277764e-03 2.642 0 0
mRNA 3'-end processing R-HSA-72187 2.624421e-03 2.581 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.823027e-03 2.549 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.823027e-03 2.549 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.831253e-03 2.548 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.861568e-03 2.543 0 0
Programmed Cell Death R-HSA-5357801 2.897398e-03 2.538 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.905585e-03 2.537 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.905585e-03 2.537 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.990937e-03 2.524 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.990937e-03 2.524 0 0
HATs acetylate histones R-HSA-3214847 3.069430e-03 2.513 0 0
Signaling by NOTCH R-HSA-157118 3.428879e-03 2.465 0 0
MAP2K and MAPK activation R-HSA-5674135 3.516094e-03 2.454 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.620184e-03 2.441 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.712411e-03 2.430 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.712411e-03 2.430 0 0
Centrosome maturation R-HSA-380287 3.692344e-03 2.433 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.660335e-03 2.436 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.113167e-03 2.386 0 0
Depyrimidination R-HSA-73928 4.113167e-03 2.386 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.562245e-03 2.341 0 0
Semaphorin interactions R-HSA-373755 4.671723e-03 2.331 0 0
MAPK family signaling cascades R-HSA-5683057 4.886133e-03 2.311 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.084453e-03 2.294 0 0
Pervasive developmental disorders R-HSA-9005895 5.099428e-03 2.292 0 0
Disorders of Nervous System Development R-HSA-9697154 5.099428e-03 2.292 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.099428e-03 2.292 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.317130e-03 2.274 0 0
HSF1-dependent transactivation R-HSA-3371571 5.805981e-03 2.236 0 0
Gene expression (Transcription) R-HSA-74160 5.891886e-03 2.230 0 0
DNA Replication R-HSA-69306 5.896985e-03 2.229 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.008608e-03 2.221 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 7.199694e-03 2.143 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 7.199694e-03 2.143 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 7.199694e-03 2.143 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 7.199694e-03 2.143 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 7.199694e-03 2.143 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 7.199694e-03 2.143 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 7.199694e-03 2.143 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 7.199694e-03 2.143 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 7.199694e-03 2.143 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 7.199694e-03 2.143 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 7.199694e-03 2.143 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.525519e-03 2.123 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.993704e-03 2.155 0 0
Gene Silencing by RNA R-HSA-211000 7.232544e-03 2.141 0 0
Smooth Muscle Contraction R-HSA-445355 7.543805e-03 2.122 0 0
Chaperone Mediated Autophagy R-HSA-9613829 7.785946e-03 2.109 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.926182e-03 2.101 0 0
RNA Polymerase II Transcription R-HSA-73857 8.040272e-03 2.095 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.100598e-03 2.091 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.803167e-03 2.055 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 8.813461e-03 2.055 0 0
TCF dependent signaling in response to WNT R-HSA-201681 9.413212e-03 2.026 0 0
Rap1 signalling R-HSA-392517 9.671348e-03 2.015 0 0
HSF1 activation R-HSA-3371511 1.024469e-02 1.990 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.067817e-02 1.972 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.106857e-02 1.956 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.125916e-02 1.948 0 0
PTEN Regulation R-HSA-6807070 1.133715e-02 1.945 0 0
Long-term potentiation R-HSA-9620244 1.168304e-02 1.932 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.168304e-02 1.932 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.186991e-02 1.926 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.186991e-02 1.926 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.186991e-02 1.926 0 0
Nephrin family interactions R-HSA-373753 1.186991e-02 1.926 0 0
Selenoamino acid metabolism R-HSA-2408522 1.268376e-02 1.897 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.280569e-02 1.893 0 0
S Phase R-HSA-69242 1.296570e-02 1.887 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.310238e-02 1.883 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.506220e-02 1.822 0 0
Metabolism of non-coding RNA R-HSA-194441 1.529635e-02 1.815 0 0
snRNP Assembly R-HSA-191859 1.529635e-02 1.815 0 0
Prolonged ERK activation events R-HSA-169893 1.414875e-02 1.849 0 0
Post NMDA receptor activation events R-HSA-438064 1.411779e-02 1.850 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.420888e-02 1.847 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.420888e-02 1.847 0 0
Glycolysis R-HSA-70171 1.365757e-02 1.865 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.543890e-02 1.811 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.564627e-02 1.806 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.565292e-02 1.805 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.565292e-02 1.805 0 0
Signaling by Interleukins R-HSA-449147 1.601770e-02 1.795 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.640599e-02 1.785 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.731165e-02 1.762 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.731165e-02 1.762 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.731165e-02 1.762 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.741573e-02 1.759 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.741573e-02 1.759 0 0
Reproduction R-HSA-1474165 1.748438e-02 1.757 0 0
Disorders of Developmental Biology R-HSA-9675151 1.751818e-02 1.757 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.753755e-02 1.756 0 0
L1CAM interactions R-HSA-373760 1.761985e-02 1.754 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.784754e-02 1.748 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.811401e-02 1.742 0 0
Translation R-HSA-72766 1.857589e-02 1.731 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.958758e-02 1.708 0 0
Signaling by WNT R-HSA-195721 1.969776e-02 1.706 0 0
RAF activation R-HSA-5673000 2.002651e-02 1.698 0 0
Recycling pathway of L1 R-HSA-437239 2.007410e-02 1.697 0 0
Signaling by VEGF R-HSA-194138 2.024834e-02 1.694 0 0
Telomere Maintenance R-HSA-157579 2.025786e-02 1.693 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.094207e-02 1.679 0 0
Signaling by Hippo R-HSA-2028269 2.140066e-02 1.670 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.204560e-02 1.657 0 0
Ephrin signaling R-HSA-3928664 2.582619e-02 1.588 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.290855e-02 1.640 0 0
Frs2-mediated activation R-HSA-170968 2.597591e-02 1.585 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.313236e-02 1.636 0 0
Ca-dependent events R-HSA-111996 2.581624e-02 1.588 0 0
Calmodulin induced events R-HSA-111933 2.607528e-02 1.584 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.250525e-02 1.648 0 0
CaM pathway R-HSA-111997 2.607528e-02 1.584 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.430998e-02 1.614 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.639871e-02 1.578 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.299733e-02 1.638 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.681819e-02 1.572 0 0
NRAGE signals death through JNK R-HSA-193648 2.421588e-02 1.616 0 0
Viral Infection Pathways R-HSA-9824446 2.307954e-02 1.637 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.421588e-02 1.616 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.826844e-02 1.549 0 0
DNA Repair R-HSA-73894 2.831761e-02 1.548 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.884858e-02 1.540 0 0
Amyloid fiber formation R-HSA-977225 2.937799e-02 1.532 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.953942e-02 1.530 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.966744e-02 1.528 0 0
ESR-mediated signaling R-HSA-8939211 2.993518e-02 1.524 0 0
Host Interactions of HIV factors R-HSA-162909 3.069425e-02 1.513 0 0
IRS activation R-HSA-74713 3.124892e-02 1.505 0 0
NrCAM interactions R-HSA-447038 3.124892e-02 1.505 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.146116e-02 1.502 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.175441e-02 1.498 0 0
Regulation of KIT signaling R-HSA-1433559 3.202082e-02 1.495 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.237466e-02 1.490 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.321797e-02 1.479 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.331291e-02 1.477 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.366165e-02 1.473 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.424181e-02 1.465 0 0
Base Excision Repair R-HSA-73884 3.463329e-02 1.461 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.466005e-02 1.460 0 0
DAG and IP3 signaling R-HSA-1489509 3.605760e-02 1.443 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.669232e-02 1.435 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.669232e-02 1.435 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.733547e-02 1.428 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.796389e-02 1.421 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.809827e-02 1.419 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.821538e-02 1.418 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.821538e-02 1.418 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.870426e-02 1.412 0 0
Josephin domain DUBs R-HSA-5689877 3.870426e-02 1.412 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.870426e-02 1.412 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.887639e-02 1.410 0 0
Protein methylation R-HSA-8876725 3.887639e-02 1.410 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.002160e-02 1.398 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.351215e-02 1.361 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 4.351215e-02 1.361 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 4.656092e-02 1.332 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.364040e-02 1.360 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.364248e-02 1.360 0 0
HCMV Early Events R-HSA-9609690 4.920869e-02 1.308 0 0
Attenuation phase R-HSA-3371568 4.183107e-02 1.379 0 0
Nuclear import of Rev protein R-HSA-180746 4.851781e-02 1.314 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.070290e-02 1.295 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.177002e-02 1.379 0 0
Ion homeostasis R-HSA-5578775 5.016552e-02 1.300 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.183107e-02 1.379 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.498800e-02 1.347 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.849878e-02 1.314 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.686159e-02 1.329 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.364248e-02 1.360 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.177313e-02 1.379 0 0
Sensory processing of sound R-HSA-9659379 4.714454e-02 1.327 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.089326e-02 1.388 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.695422e-02 1.328 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.942557e-02 1.306 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.102894e-02 1.292 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.212888e-02 1.283 0 0
Membrane Trafficking R-HSA-199991 5.373888e-02 1.270 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.477897e-02 1.261 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.508445e-02 1.259 0 0
Glucose metabolism R-HSA-70326 5.611242e-02 1.251 0 0
Late endosomal microautophagy R-HSA-9615710 5.621740e-02 1.250 0 0
Notch-HLH transcription pathway R-HSA-350054 5.688000e-02 1.245 0 0
mTORC1-mediated signalling R-HSA-166208 5.688000e-02 1.245 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.688000e-02 1.245 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.781455e-02 1.238 0 0
Co-inhibition by PD-1 R-HSA-389948 5.905279e-02 1.229 0 0
Activation of RAC1 R-HSA-428540 5.925852e-02 1.227 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.047274e-02 1.218 0 0
HIV Infection R-HSA-162906 6.221123e-02 1.206 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.326766e-02 1.199 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.326766e-02 1.199 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.338006e-02 1.198 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.444897e-02 1.191 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 6.708553e-02 1.173 0 0
Proteasome assembly R-HSA-9907900 6.918275e-02 1.160 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.918275e-02 1.160 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 7.083150e-02 1.150 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 7.083150e-02 1.150 0 0
Regulation of IFNG signaling R-HSA-877312 7.132905e-02 1.147 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.313634e-02 1.136 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.370565e-02 1.132 0 0
Neurodegenerative Diseases R-HSA-8863678 7.370565e-02 1.132 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 7.370565e-02 1.132 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.403729e-02 1.131 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.403729e-02 1.131 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.403729e-02 1.131 0 0
Synthesis of DNA R-HSA-69239 7.525257e-02 1.123 0 0
PLC beta mediated events R-HSA-112043 7.589917e-02 1.120 0 0
G0 and Early G1 R-HSA-1538133 7.890982e-02 1.103 0 0
G alpha (12/13) signalling events R-HSA-416482 7.903906e-02 1.102 0 0
Generic Transcription Pathway R-HSA-212436 7.967082e-02 1.099 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.159717e-02 1.088 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.264026e-02 1.083 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 8.455112e-02 1.073 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.455112e-02 1.073 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.455112e-02 1.073 0 0
Autophagy R-HSA-9612973 8.582400e-02 1.066 0 0
Hedgehog 'on' state R-HSA-5632684 8.648534e-02 1.063 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.205262e-02 1.036 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.151388e-01 0.939 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.151388e-01 0.939 0 0
HCN channels R-HSA-1296061 1.151388e-01 0.939 0 0
Type I hemidesmosome assembly R-HSA-446107 9.203304e-02 1.036 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 9.203304e-02 1.036 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 9.203304e-02 1.036 0 0
Lipophagy R-HSA-9613354 1.116352e-01 0.952 0 0
ALK mutants bind TKIs R-HSA-9700645 1.116352e-01 0.952 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 8.750083e-02 1.058 0 0
Insulin receptor recycling R-HSA-77387 1.148994e-01 0.940 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.994926e-02 1.046 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.140109e-01 0.943 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.153292e-01 0.938 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.116352e-01 0.952 0 0
DCC mediated attractive signaling R-HSA-418885 1.142429e-01 0.942 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.065709e-01 0.972 0 0
Negative regulation of MET activity R-HSA-6807004 9.749502e-02 1.011 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.056283e-01 0.976 0 0
HCMV Infection R-HSA-9609646 1.050114e-01 0.979 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.116352e-01 0.952 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.065709e-01 0.972 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.065709e-01 0.972 0 0
HIV Life Cycle R-HSA-162587 8.979943e-02 1.047 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 9.203304e-02 1.036 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.116352e-01 0.952 0 0
Unwinding of DNA R-HSA-176974 1.116352e-01 0.952 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.069975e-01 0.971 0 0
Signaling by NOTCH3 R-HSA-9012852 8.939271e-02 1.049 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 9.646680e-02 1.016 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.116352e-01 0.952 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 9.660013e-02 1.015 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 9.782264e-02 1.010 0 0
Developmental Biology R-HSA-1266738 1.022906e-01 0.990 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.750083e-02 1.058 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.116352e-01 0.952 0 0
Signaling by NOTCH4 R-HSA-9013694 1.055730e-01 0.976 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.142429e-01 0.942 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.036844e-01 0.984 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.230671e-02 1.035 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.036844e-01 0.984 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.124473e-01 0.949 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.100959e-01 0.958 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.038613e-01 0.984 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.406839e-02 1.027 0 0
G-protein mediated events R-HSA-112040 1.161150e-01 0.935 0 0
Signalling to ERKs R-HSA-187687 1.162932e-01 0.934 0 0
Signaling by NOTCH1 R-HSA-1980143 1.195751e-01 0.922 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.234418e-01 0.909 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.234418e-01 0.909 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.266972e-01 0.897 0 0
RET signaling R-HSA-8853659 1.268658e-01 0.897 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.279398e-01 0.893 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.279398e-01 0.893 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.279398e-01 0.893 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.279398e-01 0.893 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.279398e-01 0.893 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.281150e-01 0.892 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.305849e-01 0.884 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.305849e-01 0.884 0 0
Phosphorylation of the APC/C R-HSA-176412 1.305849e-01 0.884 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.305849e-01 0.884 0 0
Negative regulation of FLT3 R-HSA-9706369 1.305849e-01 0.884 0 0
HCMV Late Events R-HSA-9610379 1.317225e-01 0.880 0 0
Orc1 removal from chromatin R-HSA-68949 1.318376e-01 0.880 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.318376e-01 0.880 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.326656e-01 0.877 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.326656e-01 0.877 0 0
Signal attenuation R-HSA-74749 1.326656e-01 0.877 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.338207e-01 0.873 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.390561e-01 0.857 0 0
Interleukin-37 signaling R-HSA-9008059 1.390561e-01 0.857 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.400149e-01 0.854 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.412680e-01 0.850 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.756365e-01 0.755 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.756365e-01 0.755 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.756365e-01 0.755 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.756365e-01 0.755 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.756365e-01 0.755 0 0
Defective GALM causes GALAC4 R-HSA-9931929 1.756365e-01 0.755 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.756365e-01 0.755 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 1.756365e-01 0.755 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.756365e-01 0.755 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.756365e-01 0.755 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.756365e-01 0.755 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 1.756365e-01 0.755 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.474691e-01 0.831 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.474691e-01 0.831 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.474691e-01 0.831 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.813479e-01 0.741 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.813479e-01 0.741 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 1.813479e-01 0.741 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.813479e-01 0.741 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.162166e-01 0.665 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.162166e-01 0.665 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.162166e-01 0.665 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.549403e-01 0.810 0 0
Signaling by APC mutants R-HSA-4839744 1.549403e-01 0.810 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.549403e-01 0.810 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.549403e-01 0.810 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.549403e-01 0.810 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.782746e-01 0.749 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.024870e-01 0.694 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.024870e-01 0.694 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.024870e-01 0.694 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.024870e-01 0.694 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.024870e-01 0.694 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.658879e-01 0.780 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.658879e-01 0.780 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.658879e-01 0.780 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.846852e-01 0.734 0 0
PKA activation in glucagon signalling R-HSA-164378 1.846852e-01 0.734 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.041326e-01 0.690 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.041326e-01 0.690 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.519514e-01 0.818 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.456431e-01 0.837 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.083204e-01 0.681 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.611203e-01 0.793 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.715220e-01 0.766 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.485213e-01 0.828 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.485213e-01 0.828 0 0
Polo-like kinase mediated events R-HSA-156711 1.846852e-01 0.734 0 0
DNA strand elongation R-HSA-69190 1.653558e-01 0.782 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 1.613146e-01 0.792 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.456431e-01 0.837 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.863738e-01 0.730 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.935725e-01 0.713 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.792399e-01 0.747 0 0
Nuclear RNA decay R-HSA-9930044 1.792399e-01 0.747 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.613146e-01 0.792 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.455274e-01 0.837 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.083204e-01 0.681 0 0
MTOR signalling R-HSA-165159 2.129078e-01 0.672 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.024870e-01 0.694 0 0
PKA activation R-HSA-163615 1.846852e-01 0.734 0 0
Trafficking of AMPA receptors R-HSA-399719 1.519514e-01 0.818 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.024870e-01 0.694 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.505650e-01 0.822 0 0
PCP/CE pathway R-HSA-4086400 2.149777e-01 0.668 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.672861e-01 0.777 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.999416e-01 0.699 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.782746e-01 0.749 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.792399e-01 0.747 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.863738e-01 0.730 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.129078e-01 0.672 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.944702e-01 0.711 0 0
Glycogen metabolism R-HSA-8982491 1.736485e-01 0.760 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.127508e-01 0.672 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.994682e-01 0.700 0 0
Kinesins R-HSA-983189 2.160191e-01 0.666 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 1.834900e-01 0.736 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.754220e-01 0.756 0 0
Selective autophagy R-HSA-9663891 1.518808e-01 0.818 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.813479e-01 0.741 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.999416e-01 0.699 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.792399e-01 0.747 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.584378e-01 0.800 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 1.658879e-01 0.780 0 0
Inhibition of PKR R-HSA-169131 1.756365e-01 0.755 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 1.474691e-01 0.831 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.782746e-01 0.749 0 0
Signaling by AXIN mutants R-HSA-4839735 1.782746e-01 0.749 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.478266e-01 0.830 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.024870e-01 0.694 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.083204e-01 0.681 0 0
Hedgehog 'off' state R-HSA-5610787 1.926702e-01 0.715 0 0
Cilium Assembly R-HSA-5617833 1.656724e-01 0.781 0 0
Signaling by Hedgehog R-HSA-5358351 1.772249e-01 0.751 0 0
HDMs demethylate histones R-HSA-3214842 1.834900e-01 0.736 0 0
Death Receptor Signaling R-HSA-73887 1.672861e-01 0.777 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.599080e-01 0.796 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.584870e-01 0.800 0 0
tRNA processing in the nucleus R-HSA-6784531 1.455274e-01 0.837 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.129078e-01 0.672 0 0
G1/S Transition R-HSA-69206 2.031215e-01 0.692 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.563811e-01 0.806 0 0
Degradation of CDH1 R-HSA-9766229 1.907120e-01 0.720 0 0
TCR signaling R-HSA-202403 2.077980e-01 0.682 0 0
FLT3 Signaling R-HSA-9607240 1.863738e-01 0.730 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.675661e-01 0.776 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.680802e-01 0.774 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.162166e-01 0.665 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.478266e-01 0.830 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.792399e-01 0.747 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.994682e-01 0.700 0 0
Regulation of TP53 Activity R-HSA-5633007 1.480933e-01 0.829 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.478266e-01 0.830 0 0
Potential therapeutics for SARS R-HSA-9679191 2.026026e-01 0.693 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 1.813479e-01 0.741 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.168699e-01 0.664 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.863738e-01 0.730 0 0
Maturation of nucleoprotein R-HSA-9694631 2.041326e-01 0.690 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.813479e-01 0.741 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.478266e-01 0.830 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.792399e-01 0.747 0 0
SARS-CoV Infections R-HSA-9679506 1.730498e-01 0.762 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.234496e-01 0.651 0 0
Regulation of Apoptosis R-HSA-169911 2.234496e-01 0.651 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.234496e-01 0.651 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.234496e-01 0.651 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.241435e-01 0.649 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.241435e-01 0.649 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.241435e-01 0.649 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.241435e-01 0.649 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.241435e-01 0.649 0 0
Signal transduction by L1 R-HSA-445144 2.241435e-01 0.649 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.264064e-01 0.645 0 0
TBC/RABGAPs R-HSA-8854214 2.266680e-01 0.645 0 0
Signaling by SCF-KIT R-HSA-1433557 2.266680e-01 0.645 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.268708e-01 0.644 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.274015e-01 0.643 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.274015e-01 0.643 0 0
Opioid Signalling R-HSA-111885 2.278878e-01 0.642 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.342227e-01 0.630 0 0
Signaling by MET R-HSA-6806834 2.359397e-01 0.627 0 0
G1/S-Specific Transcription R-HSA-69205 2.389246e-01 0.622 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.407233e-01 0.618 0 0
Netrin-1 signaling R-HSA-373752 2.407233e-01 0.618 0 0
RMTs methylate histone arginines R-HSA-3214858 2.407233e-01 0.618 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.408048e-01 0.618 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.446314e-01 0.611 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.446314e-01 0.611 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.446314e-01 0.611 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.446314e-01 0.611 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.446314e-01 0.611 0 0
Nucleotide Excision Repair R-HSA-5696398 2.464331e-01 0.608 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.515303e-01 0.599 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.515303e-01 0.599 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.515303e-01 0.599 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.515303e-01 0.599 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 2.515303e-01 0.599 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.515303e-01 0.599 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.515303e-01 0.599 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.515303e-01 0.599 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.516062e-01 0.599 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.516062e-01 0.599 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.516062e-01 0.599 0 0
SOS-mediated signalling R-HSA-112412 2.516062e-01 0.599 0 0
Recycling of eIF2:GDP R-HSA-72731 2.516062e-01 0.599 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 2.516062e-01 0.599 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.516062e-01 0.599 0 0
CHL1 interactions R-HSA-447041 2.516062e-01 0.599 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.519473e-01 0.599 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.520363e-01 0.599 0 0
Signaling by PTK6 R-HSA-8848021 2.520363e-01 0.599 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.528503e-01 0.597 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.528503e-01 0.597 0 0
Signal regulatory protein family interactions R-HSA-391160 2.528503e-01 0.597 0 0
Degradation of DVL R-HSA-4641258 2.547097e-01 0.594 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.547097e-01 0.594 0 0
Degradation of AXIN R-HSA-4641257 2.547097e-01 0.594 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.550473e-01 0.593 0 0
Signaling by NTRKs R-HSA-166520 2.592870e-01 0.586 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.204411e-01 0.494 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.204411e-01 0.494 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.204411e-01 0.494 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.830111e-01 0.417 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.830111e-01 0.417 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 3.830111e-01 0.417 0 0
Defective CYP1B1 causes Glaucoma R-HSA-5579000 3.830111e-01 0.417 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.830111e-01 0.417 0 0
Defective ABCC2 causes DJS R-HSA-5679001 3.830111e-01 0.417 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 2.871257e-01 0.542 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.871257e-01 0.542 0 0
Formation of annular gap junctions R-HSA-196025 2.871257e-01 0.542 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.871257e-01 0.542 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.871257e-01 0.542 0 0
ARMS-mediated activation R-HSA-170984 3.224514e-01 0.492 0 0
Gap junction degradation R-HSA-190873 3.224514e-01 0.492 0 0
CASP8 activity is inhibited R-HSA-5218900 3.224514e-01 0.492 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.398234e-01 0.357 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.398234e-01 0.357 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.398234e-01 0.357 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.398234e-01 0.357 0 0
Erythropoietin activates RAS R-HSA-9027284 2.786753e-01 0.555 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.786753e-01 0.555 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.573183e-01 0.447 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.573183e-01 0.447 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.573183e-01 0.447 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.573183e-01 0.447 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.308751e-01 0.480 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 3.308751e-01 0.480 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.915114e-01 0.407 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 3.915114e-01 0.407 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.914074e-01 0.309 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.914074e-01 0.309 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.914074e-01 0.309 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.914074e-01 0.309 0 0
Defective F9 activation R-HSA-9673221 4.914074e-01 0.309 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.296786e-01 0.482 0 0
Deadenylation of mRNA R-HSA-429947 3.296786e-01 0.482 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.248595e-01 0.372 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.248595e-01 0.372 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.829579e-01 0.417 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.513197e-01 0.454 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.443144e-01 0.463 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.729670e-01 0.428 0 0
Regulation of signaling by CBL R-HSA-912631 4.086805e-01 0.389 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.572283e-01 0.340 0 0
Leading Strand Synthesis R-HSA-69109 4.572283e-01 0.340 0 0
Polymerase switching R-HSA-69091 4.572283e-01 0.340 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.945549e-01 0.404 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.945549e-01 0.404 0 0
Cristae formation R-HSA-8949613 3.945549e-01 0.404 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.158430e-01 0.501 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.160225e-01 0.381 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.885155e-01 0.311 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.605789e-01 0.443 0 0
Lagging Strand Synthesis R-HSA-69186 4.590374e-01 0.338 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.216933e-01 0.375 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.835237e-01 0.316 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.186459e-01 0.285 0 0
EGFR downregulation R-HSA-182971 4.791616e-01 0.320 0 0
FGFR2 alternative splicing R-HSA-6803529 5.074666e-01 0.295 0 0
PKR-mediated signaling R-HSA-9833482 3.465608e-01 0.460 0 0
Integrin signaling R-HSA-354192 3.255126e-01 0.487 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 3.829579e-01 0.417 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.035605e-01 0.518 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.035605e-01 0.518 0 0
Signaling by EGFR R-HSA-177929 4.226755e-01 0.374 0 0
MET promotes cell motility R-HSA-8875878 2.707684e-01 0.567 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.583754e-01 0.339 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.785264e-01 0.422 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.785264e-01 0.422 0 0
Activation of SMO R-HSA-5635838 3.047290e-01 0.516 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.248595e-01 0.372 0 0
Activation of the pre-replicative complex R-HSA-68962 4.583754e-01 0.339 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.385532e-01 0.358 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.373133e-01 0.359 0 0
TGFBR3 expression R-HSA-9839394 3.513197e-01 0.454 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.248595e-01 0.372 0 0
Aggrephagy R-HSA-9646399 3.035605e-01 0.518 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.573183e-01 0.447 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.296786e-01 0.482 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.114495e-01 0.291 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.785264e-01 0.422 0 0
Regulation of CDH11 function R-HSA-9762292 3.573183e-01 0.447 0 0
PI3K/AKT activation R-HSA-198203 3.573183e-01 0.447 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.047290e-01 0.516 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.248595e-01 0.372 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.226860e-01 0.491 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.983921e-01 0.525 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 4.753548e-01 0.323 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.605789e-01 0.443 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 3.047290e-01 0.516 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.086805e-01 0.389 0 0
Regulation by c-FLIP R-HSA-3371378 2.871257e-01 0.542 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.786753e-01 0.555 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 4.914074e-01 0.309 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.248595e-01 0.372 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.572283e-01 0.340 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 5.047912e-01 0.297 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.729670e-01 0.428 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.202212e-01 0.495 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.594413e-01 0.444 0 0
Integration of provirus R-HSA-162592 4.248595e-01 0.372 0 0
Repression of WNT target genes R-HSA-4641265 4.572283e-01 0.340 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.945549e-01 0.404 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.871257e-01 0.542 0 0
Signaling by ERBB2 R-HSA-1227986 4.841055e-01 0.315 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.835237e-01 0.316 0 0
Glycogen synthesis R-HSA-3322077 4.340667e-01 0.362 0 0
Dimerization of procaspase-8 R-HSA-69416 2.871257e-01 0.542 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.398234e-01 0.357 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.573183e-01 0.447 0 0
PTK6 Down-Regulation R-HSA-8849472 4.914074e-01 0.309 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.202212e-01 0.495 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.443144e-01 0.463 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.186459e-01 0.285 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.699908e-01 0.569 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.708375e-01 0.327 0 0
Neurexins and neuroligins R-HSA-6794361 3.605789e-01 0.443 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.729670e-01 0.428 0 0
Mitochondrial biogenesis R-HSA-1592230 3.883943e-01 0.411 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.138490e-01 0.503 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.398234e-01 0.357 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.915114e-01 0.407 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.914074e-01 0.309 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.047673e-01 0.393 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.186459e-01 0.285 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.333191e-01 0.363 0 0
Interferon Signaling R-HSA-913531 3.953948e-01 0.403 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.308751e-01 0.480 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.708359e-01 0.431 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.900574e-01 0.310 0 0
UCH proteinases R-HSA-5689603 2.970144e-01 0.527 0 0
Platelet degranulation R-HSA-114608 5.051185e-01 0.297 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.333191e-01 0.363 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.083392e-01 0.294 0 0
Macroautophagy R-HSA-1632852 2.725589e-01 0.565 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.204411e-01 0.494 0 0
Adenosine P1 receptors R-HSA-417973 3.830111e-01 0.417 0 0
MET interacts with TNS proteins R-HSA-8875513 3.830111e-01 0.417 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.047290e-01 0.516 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.915114e-01 0.407 0 0
Reelin signalling pathway R-HSA-8866376 4.914074e-01 0.309 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.914074e-01 0.309 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.160225e-01 0.381 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.885155e-01 0.311 0 0
DARPP-32 events R-HSA-180024 4.373133e-01 0.359 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.047673e-01 0.393 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.385532e-01 0.358 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.255126e-01 0.487 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.913665e-01 0.536 0 0
Vesicle-mediated transport R-HSA-5653656 4.727308e-01 0.325 0 0
Heme signaling R-HSA-9707616 3.654395e-01 0.437 0 0
Stabilization of p53 R-HSA-69541 2.870642e-01 0.542 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.767793e-01 0.322 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 3.224514e-01 0.492 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.914074e-01 0.309 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.197339e-01 0.377 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.768411e-01 0.424 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.144941e-01 0.502 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.144941e-01 0.502 0 0
FLT3 signaling in disease R-HSA-9682385 4.009350e-01 0.397 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.224514e-01 0.492 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.786753e-01 0.555 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.866986e-01 0.543 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.914074e-01 0.309 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.707684e-01 0.567 0 0
Signaling by LTK R-HSA-9842663 4.572283e-01 0.340 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.451281e-01 0.462 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.451281e-01 0.462 0 0
Cardiac conduction R-HSA-5576891 3.497026e-01 0.456 0 0
Signaling by TGFB family members R-HSA-9006936 3.618762e-01 0.441 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.224514e-01 0.492 0 0
Rab regulation of trafficking R-HSA-9007101 2.891406e-01 0.539 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.068248e-01 0.513 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.074666e-01 0.295 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.569890e-01 0.447 0 0
Intracellular oxygen transport R-HSA-8981607 3.830111e-01 0.417 0 0
NADE modulates death signalling R-HSA-205025 4.398234e-01 0.357 0 0
2-LTR circle formation R-HSA-164843 3.573183e-01 0.447 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.047290e-01 0.516 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 4.914074e-01 0.309 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.914074e-01 0.309 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.248595e-01 0.372 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.068248e-01 0.513 0 0
Platelet sensitization by LDL R-HSA-432142 3.829579e-01 0.417 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.035605e-01 0.518 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.820706e-01 0.418 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.590374e-01 0.338 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.798191e-01 0.420 0 0
Physiological factors R-HSA-5578768 5.186459e-01 0.285 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.114495e-01 0.291 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.991979e-01 0.302 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.605789e-01 0.443 0 0
Protein hydroxylation R-HSA-9629569 4.340667e-01 0.362 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.573183e-01 0.447 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.186459e-01 0.285 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.802526e-01 0.319 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.829579e-01 0.417 0 0
Interleukin-18 signaling R-HSA-9012546 2.871257e-01 0.542 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.224514e-01 0.492 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.398234e-01 0.357 0 0
Dopamine receptors R-HSA-390651 4.398234e-01 0.357 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.573183e-01 0.447 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.914074e-01 0.309 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.914074e-01 0.309 0 0
Co-inhibition by BTLA R-HSA-9927353 4.914074e-01 0.309 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.248595e-01 0.372 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.829579e-01 0.417 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.009350e-01 0.397 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.197339e-01 0.377 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.690697e-01 0.433 0 0
Signaling by ALK R-HSA-201556 4.569796e-01 0.340 0 0
Generation of second messenger molecules R-HSA-202433 3.035605e-01 0.518 0 0
Gluconeogenesis R-HSA-70263 4.553188e-01 0.342 0 0
Interleukin-7 signaling R-HSA-1266695 3.513197e-01 0.454 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.081137e-01 0.511 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.035605e-01 0.518 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.572283e-01 0.340 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.572283e-01 0.340 0 0
ABC-family proteins mediated transport R-HSA-382556 2.804907e-01 0.552 0 0
Growth hormone receptor signaling R-HSA-982772 3.081137e-01 0.511 0 0
Diseases of DNA repair R-HSA-9675135 4.216933e-01 0.375 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.224514e-01 0.492 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.786753e-01 0.555 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.786753e-01 0.555 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.248595e-01 0.372 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.443144e-01 0.463 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.631824e-01 0.440 0 0
FOXO-mediated transcription R-HSA-9614085 2.702669e-01 0.568 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.141464e-01 0.289 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.943516e-01 0.306 0 0
Downstream signal transduction R-HSA-186763 4.791616e-01 0.320 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.047673e-01 0.393 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.047673e-01 0.393 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.885155e-01 0.311 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.835237e-01 0.316 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.569796e-01 0.340 0 0
Assembly Of The HIV Virion R-HSA-175474 4.835237e-01 0.316 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.062770e-01 0.514 0 0
HDL assembly R-HSA-8963896 5.186459e-01 0.285 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.935213e-01 0.307 0 0
Signaling by Leptin R-HSA-2586552 3.573183e-01 0.447 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.086805e-01 0.389 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.885155e-01 0.311 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.885155e-01 0.311 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 4.569796e-01 0.340 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.186459e-01 0.285 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.197400e-01 0.284 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.216424e-01 0.283 0 0
Signaling by Insulin receptor R-HSA-74752 5.234756e-01 0.281 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.291125e-01 0.276 0 0
Neutrophil degranulation R-HSA-6798695 5.299216e-01 0.276 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.308160e-01 0.275 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.308160e-01 0.275 0 0
Syndecan interactions R-HSA-3000170 5.308160e-01 0.275 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.368547e-01 0.270 0 0
TRAIL signaling R-HSA-75158 5.382441e-01 0.269 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.382441e-01 0.269 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.382441e-01 0.269 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.382441e-01 0.269 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.382441e-01 0.269 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.382441e-01 0.269 0 0
Phosphorylation of Emi1 R-HSA-176417 5.382441e-01 0.269 0 0
Signaling by MST1 R-HSA-8852405 5.382441e-01 0.269 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.382441e-01 0.269 0 0
NGF-independant TRKA activation R-HSA-187024 5.382441e-01 0.269 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.382441e-01 0.269 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.382441e-01 0.269 0 0
Synthesis of PS R-HSA-1483101 5.382441e-01 0.269 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.382441e-01 0.269 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.382441e-01 0.269 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.382441e-01 0.269 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.382441e-01 0.269 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.382441e-01 0.269 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.382441e-01 0.269 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.382441e-01 0.269 0 0
Ion transport by P-type ATPases R-HSA-936837 5.435441e-01 0.265 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.464855e-01 0.262 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.475672e-01 0.262 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.475672e-01 0.262 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.475672e-01 0.262 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.475672e-01 0.262 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.475672e-01 0.262 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.475672e-01 0.262 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.475672e-01 0.262 0 0
Plasma lipoprotein assembly R-HSA-8963898 5.535304e-01 0.257 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.548852e-01 0.256 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.548852e-01 0.256 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.551990e-01 0.256 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.579136e-01 0.253 0 0
Cellular response to hypoxia R-HSA-1234174 5.579625e-01 0.253 0 0
Dual Incision in GG-NER R-HSA-5696400 5.587599e-01 0.253 0 0
Mitophagy R-HSA-5205647 5.587599e-01 0.253 0 0
Signaling by NOTCH2 R-HSA-1980145 5.587599e-01 0.253 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 5.630241e-01 0.249 0 0
Surfactant metabolism R-HSA-5683826 5.635466e-01 0.249 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.652982e-01 0.248 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.679973e-01 0.246 0 0
G alpha (z) signalling events R-HSA-418597 5.679973e-01 0.246 0 0
Interleukin-1 family signaling R-HSA-446652 5.746727e-01 0.241 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.752467e-01 0.240 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.752467e-01 0.240 0 0
Atorvastatin ADME R-HSA-9754706 5.752467e-01 0.240 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.755763e-01 0.240 0 0
Tight junction interactions R-HSA-420029 5.755763e-01 0.240 0 0
Oncogene Induced Senescence R-HSA-2559585 5.776136e-01 0.238 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.776136e-01 0.238 0 0
PERK regulates gene expression R-HSA-381042 5.776136e-01 0.238 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.802759e-01 0.236 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.802759e-01 0.236 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.802759e-01 0.236 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.802759e-01 0.236 0 0
Somitogenesis R-HSA-9824272 5.802759e-01 0.236 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.804341e-01 0.236 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.807700e-01 0.236 0 0
Signaling by LTK in cancer R-HSA-9842640 5.807700e-01 0.236 0 0
STAT5 Activation R-HSA-9645135 5.807700e-01 0.236 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.807700e-01 0.236 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.807700e-01 0.236 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.807700e-01 0.236 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 5.807700e-01 0.236 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 5.807700e-01 0.236 0 0
Neurofascin interactions R-HSA-447043 5.807700e-01 0.236 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.807700e-01 0.236 0 0
CREB phosphorylation R-HSA-199920 5.807700e-01 0.236 0 0
VLDL assembly R-HSA-8866423 5.807700e-01 0.236 0 0
HDL clearance R-HSA-8964011 5.807700e-01 0.236 0 0
Nef and signal transduction R-HSA-164944 5.807700e-01 0.236 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.834602e-01 0.234 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.959995e-01 0.225 0 0
RNA Polymerase III Transcription R-HSA-74158 5.959995e-01 0.225 0 0
Signaling by TGFBR3 R-HSA-9839373 5.966560e-01 0.224 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.969273e-01 0.224 0 0
Myogenesis R-HSA-525793 5.969273e-01 0.224 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.969273e-01 0.224 0 0
Transcription of the HIV genome R-HSA-167172 5.999334e-01 0.222 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.016677e-01 0.221 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.016677e-01 0.221 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.016677e-01 0.221 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.016677e-01 0.221 0 0
Galactose catabolism R-HSA-70370 6.016677e-01 0.221 0 0
ER-Phagosome pathway R-HSA-1236974 6.042161e-01 0.219 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.088034e-01 0.216 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.115653e-01 0.214 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.175633e-01 0.209 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.175633e-01 0.209 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.175633e-01 0.209 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.175633e-01 0.209 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.193818e-01 0.208 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 6.193818e-01 0.208 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.193818e-01 0.208 0 0
Disinhibition of SNARE formation R-HSA-114516 6.193818e-01 0.208 0 0
PTK6 Expression R-HSA-8849473 6.193818e-01 0.208 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.193818e-01 0.208 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.193818e-01 0.208 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.193818e-01 0.208 0 0
Cysteine formation from homocysteine R-HSA-1614603 6.193818e-01 0.208 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.193818e-01 0.208 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.193818e-01 0.208 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.193818e-01 0.208 0 0
VLDL clearance R-HSA-8964046 6.193818e-01 0.208 0 0
LDL remodeling R-HSA-8964041 6.193818e-01 0.208 0 0
Activation of TRKA receptors R-HSA-187015 6.193818e-01 0.208 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.193818e-01 0.208 0 0
Maturation of replicase proteins R-HSA-9694301 6.193818e-01 0.208 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.267303e-01 0.203 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.268272e-01 0.203 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.268272e-01 0.203 0 0
Glycogen storage diseases R-HSA-3229121 6.268272e-01 0.203 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.268272e-01 0.203 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.268272e-01 0.203 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.268272e-01 0.203 0 0
Specification of primordial germ cells R-HSA-9827857 6.268272e-01 0.203 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.268272e-01 0.203 0 0
Extension of Telomeres R-HSA-180786 6.270190e-01 0.203 0 0
GPER1 signaling R-HSA-9634597 6.283099e-01 0.202 0 0
NGF-stimulated transcription R-HSA-9031628 6.283099e-01 0.202 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.312979e-01 0.200 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.312979e-01 0.200 0 0
HIV elongation arrest and recovery R-HSA-167287 6.374705e-01 0.196 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.374705e-01 0.196 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.374705e-01 0.196 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.398321e-01 0.194 0 0
DNA Damage Bypass R-HSA-73893 6.435596e-01 0.191 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.481838e-01 0.188 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.481838e-01 0.188 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.507335e-01 0.187 0 0
GAB1 signalosome R-HSA-180292 6.507335e-01 0.187 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.507335e-01 0.187 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.507335e-01 0.187 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.507335e-01 0.187 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 6.507335e-01 0.187 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.507335e-01 0.187 0 0
Mismatch Repair R-HSA-5358508 6.507335e-01 0.187 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.507335e-01 0.187 0 0
Inositol phosphate metabolism R-HSA-1483249 6.508603e-01 0.187 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.509107e-01 0.186 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.513834e-01 0.186 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.524939e-01 0.185 0 0
RSK activation R-HSA-444257 6.544395e-01 0.184 0 0
phospho-PLA2 pathway R-HSA-111995 6.544395e-01 0.184 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.544395e-01 0.184 0 0
MET receptor recycling R-HSA-8875656 6.544395e-01 0.184 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.544395e-01 0.184 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.544395e-01 0.184 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.544395e-01 0.184 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.544395e-01 0.184 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.544395e-01 0.184 0 0
Adrenoceptors R-HSA-390696 6.544395e-01 0.184 0 0
Interleukin-23 signaling R-HSA-9020933 6.544395e-01 0.184 0 0
Aquaporin-mediated transport R-HSA-445717 6.547078e-01 0.184 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.547078e-01 0.184 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.547078e-01 0.184 0 0
Signaling by Erythropoietin R-HSA-9006335 6.566403e-01 0.183 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.566403e-01 0.183 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.566403e-01 0.183 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 6.566403e-01 0.183 0 0
Platelet calcium homeostasis R-HSA-418360 6.566403e-01 0.183 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.619863e-01 0.179 0 0
HIV Transcription Elongation R-HSA-167169 6.645483e-01 0.177 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.645483e-01 0.177 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.645483e-01 0.177 0 0
Ca2+ pathway R-HSA-4086398 6.649702e-01 0.177 0 0
Mitochondrial protein import R-HSA-1268020 6.680662e-01 0.175 0 0
Circadian clock R-HSA-9909396 6.706378e-01 0.174 0 0
MHC class II antigen presentation R-HSA-2132295 6.706405e-01 0.174 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.734040e-01 0.172 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.734040e-01 0.172 0 0
Translesion Synthesis by POLH R-HSA-110320 6.734040e-01 0.172 0 0
Other interleukin signaling R-HSA-449836 6.734040e-01 0.172 0 0
The NLRP3 inflammasome R-HSA-844456 6.734040e-01 0.172 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.734040e-01 0.172 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.750689e-01 0.171 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.750689e-01 0.171 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.750689e-01 0.171 0 0
Activation of BH3-only proteins R-HSA-114452 6.750689e-01 0.171 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.803854e-01 0.167 0 0
WNT mediated activation of DVL R-HSA-201688 6.862699e-01 0.164 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.862699e-01 0.164 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.862699e-01 0.164 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 6.862699e-01 0.164 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.862699e-01 0.164 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.862699e-01 0.164 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.862699e-01 0.164 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 6.862699e-01 0.164 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.862699e-01 0.164 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.862699e-01 0.164 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.862699e-01 0.164 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.862699e-01 0.164 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.927567e-01 0.159 0 0
Budding and maturation of HIV virion R-HSA-162588 6.927567e-01 0.159 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.948635e-01 0.158 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.948635e-01 0.158 0 0
Formation of definitive endoderm R-HSA-9823730 6.948635e-01 0.158 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.956916e-01 0.158 0 0
Intra-Golgi traffic R-HSA-6811438 6.956916e-01 0.158 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.005194e-01 0.155 0 0
Pyruvate metabolism R-HSA-70268 7.075451e-01 0.150 0 0
Signaling by WNT in cancer R-HSA-4791275 7.097079e-01 0.149 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.151426e-01 0.146 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.151426e-01 0.146 0 0
G-protein activation R-HSA-202040 7.151426e-01 0.146 0 0
ERK/MAPK targets R-HSA-198753 7.151426e-01 0.146 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 7.151426e-01 0.146 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.151426e-01 0.146 0 0
Basigin interactions R-HSA-210991 7.151426e-01 0.146 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.151701e-01 0.146 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.151701e-01 0.146 0 0
Formation of apoptosome R-HSA-111458 7.151701e-01 0.146 0 0
Binding and entry of HIV virion R-HSA-173107 7.151701e-01 0.146 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.151701e-01 0.146 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.151701e-01 0.146 0 0
Arachidonate production from DAG R-HSA-426048 7.151701e-01 0.146 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.151701e-01 0.146 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.151701e-01 0.146 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.151701e-01 0.146 0 0
ABC transporter disorders R-HSA-5619084 7.231005e-01 0.141 0 0
Regulation of insulin secretion R-HSA-422356 7.240304e-01 0.140 0 0
G-protein beta:gamma signalling R-HSA-397795 7.259300e-01 0.139 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.259300e-01 0.139 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.259300e-01 0.139 0 0
Paracetamol ADME R-HSA-9753281 7.265155e-01 0.139 0 0
Interferon gamma signaling R-HSA-877300 7.278207e-01 0.138 0 0
Cellular response to chemical stress R-HSA-9711123 7.307077e-01 0.136 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.342767e-01 0.134 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 7.342767e-01 0.134 0 0
Infectious disease R-HSA-5663205 7.379584e-01 0.132 0 0
Downstream TCR signaling R-HSA-202424 7.383183e-01 0.132 0 0
Cyclin D associated events in G1 R-HSA-69231 7.384236e-01 0.132 0 0
G1 Phase R-HSA-69236 7.384236e-01 0.132 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.388880e-01 0.131 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.414096e-01 0.130 0 0
vRNP Assembly R-HSA-192905 7.414096e-01 0.130 0 0
vRNA Synthesis R-HSA-192814 7.414096e-01 0.130 0 0
Chylomicron assembly R-HSA-8963888 7.414096e-01 0.130 0 0
Synthesis of PI R-HSA-1483226 7.414096e-01 0.130 0 0
Propionyl-CoA catabolism R-HSA-71032 7.414096e-01 0.130 0 0
Bicarbonate transporters R-HSA-425381 7.414096e-01 0.130 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.414096e-01 0.130 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 7.414096e-01 0.130 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.414096e-01 0.130 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.414096e-01 0.130 0 0
PECAM1 interactions R-HSA-210990 7.414096e-01 0.130 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.414096e-01 0.130 0 0
Interleukin-2 signaling R-HSA-9020558 7.414096e-01 0.130 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.414096e-01 0.130 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.414334e-01 0.130 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.414334e-01 0.130 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.414334e-01 0.130 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.414334e-01 0.130 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.520930e-01 0.124 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.523046e-01 0.124 0 0
LDL clearance R-HSA-8964038 7.523046e-01 0.124 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.523046e-01 0.124 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.523046e-01 0.124 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.523046e-01 0.124 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.562307e-01 0.121 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.562307e-01 0.121 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.562307e-01 0.121 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.562307e-01 0.121 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 7.562307e-01 0.121 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.562307e-01 0.121 0 0
Adipogenesis R-HSA-9843745 7.572642e-01 0.121 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.623903e-01 0.118 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.641946e-01 0.117 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.652333e-01 0.116 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.652333e-01 0.116 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.652333e-01 0.116 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.652333e-01 0.116 0 0
Plasmalogen biosynthesis R-HSA-75896 7.652333e-01 0.116 0 0
ERKs are inactivated R-HSA-202670 7.652333e-01 0.116 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.652333e-01 0.116 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.652333e-01 0.116 0 0
Sodium/Calcium exchangers R-HSA-425561 7.652333e-01 0.116 0 0
Protein folding R-HSA-391251 7.667883e-01 0.115 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.692677e-01 0.114 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.692677e-01 0.114 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.692677e-01 0.114 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.692677e-01 0.114 0 0
Biosynthesis of maresins R-HSA-9018682 7.692677e-01 0.114 0 0
Triglyceride metabolism R-HSA-8979227 7.735265e-01 0.112 0 0
Synthesis of PC R-HSA-1483191 7.764518e-01 0.110 0 0
Adaptive Immune System R-HSA-1280218 7.770566e-01 0.110 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.837683e-01 0.106 0 0
Triglyceride catabolism R-HSA-163560 7.837683e-01 0.106 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.842588e-01 0.106 1 1
Metabolism of polyamines R-HSA-351202 7.842588e-01 0.106 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 7.852091e-01 0.105 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.852091e-01 0.105 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.852091e-01 0.105 0 0
Complex III assembly R-HSA-9865881 7.852091e-01 0.105 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.868634e-01 0.104 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.868634e-01 0.104 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.868634e-01 0.104 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.868634e-01 0.104 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.868634e-01 0.104 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 7.868634e-01 0.104 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 7.868634e-01 0.104 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.868634e-01 0.104 0 0
OAS antiviral response R-HSA-8983711 7.868634e-01 0.104 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.868634e-01 0.104 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.868634e-01 0.104 0 0
Interleukin-15 signaling R-HSA-8983432 7.868634e-01 0.104 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.868634e-01 0.104 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.868634e-01 0.104 0 0
Co-stimulation by CD28 R-HSA-389356 7.881140e-01 0.103 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.887463e-01 0.103 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.945926e-01 0.100 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.001730e-01 0.097 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.065017e-01 0.093 0 0
Processing of SMDT1 R-HSA-8949664 8.065017e-01 0.093 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.065017e-01 0.093 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.065017e-01 0.093 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.065017e-01 0.093 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.065017e-01 0.093 0 0
Maturation of nucleoprotein R-HSA-9683610 8.065017e-01 0.093 0 0
Interleukin-6 signaling R-HSA-1059683 8.065017e-01 0.093 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.078341e-01 0.093 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.093973e-01 0.092 0 0
Azathioprine ADME R-HSA-9748787 8.099737e-01 0.092 0 0
PI3K Cascade R-HSA-109704 8.099737e-01 0.092 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 8.108403e-01 0.091 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.108403e-01 0.091 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.142043e-01 0.089 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.142043e-01 0.089 0 0
TRP channels R-HSA-3295583 8.142043e-01 0.089 0 0
Urea cycle R-HSA-70635 8.142043e-01 0.089 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.175569e-01 0.087 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.178955e-01 0.087 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.202012e-01 0.086 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.202012e-01 0.086 0 0
Insulin receptor signalling cascade R-HSA-74751 8.232689e-01 0.084 0 0
IGF1R signaling cascade R-HSA-2428924 8.232689e-01 0.084 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.232689e-01 0.084 0 0
Removal of the Flap Intermediate R-HSA-69166 8.243317e-01 0.084 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.243317e-01 0.084 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.243317e-01 0.084 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 8.243317e-01 0.084 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.243317e-01 0.084 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.243317e-01 0.084 0 0
Hydrolysis of LPC R-HSA-1483115 8.243317e-01 0.084 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.243317e-01 0.084 0 0
cGMP effects R-HSA-418457 8.243317e-01 0.084 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.243317e-01 0.084 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.243317e-01 0.084 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.243317e-01 0.084 0 0
Zinc transporters R-HSA-435354 8.243317e-01 0.084 0 0
P2Y receptors R-HSA-417957 8.243317e-01 0.084 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.243670e-01 0.084 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.273476e-01 0.082 0 0
Insulin processing R-HSA-264876 8.273476e-01 0.082 0 0
Triglyceride biosynthesis R-HSA-75109 8.273476e-01 0.082 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.273476e-01 0.082 0 0
Synthesis of PE R-HSA-1483213 8.273476e-01 0.082 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.273476e-01 0.082 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.299554e-01 0.081 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.311250e-01 0.080 0 0
Diseases of Immune System R-HSA-5260271 8.311250e-01 0.080 0 0
Interleukin-2 family signaling R-HSA-451927 8.311250e-01 0.080 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.320775e-01 0.080 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.322935e-01 0.080 0 0
Telomere Extension By Telomerase R-HSA-171319 8.396474e-01 0.076 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.396474e-01 0.076 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.396474e-01 0.076 0 0
Inflammasomes R-HSA-622312 8.396474e-01 0.076 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.405196e-01 0.075 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.405196e-01 0.075 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.405196e-01 0.075 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.405196e-01 0.075 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.405196e-01 0.075 0 0
Translesion synthesis by REV1 R-HSA-110312 8.405196e-01 0.075 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.405196e-01 0.075 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.405196e-01 0.075 0 0
Biotin transport and metabolism R-HSA-196780 8.405196e-01 0.075 0 0
p38MAPK events R-HSA-171007 8.405196e-01 0.075 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.405196e-01 0.075 0 0
p75NTR signals via NF-kB R-HSA-193639 8.405196e-01 0.075 0 0
DNA Damage Reversal R-HSA-73942 8.405196e-01 0.075 0 0
Neddylation R-HSA-8951664 8.409203e-01 0.075 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.414735e-01 0.075 0 0
Disease R-HSA-1643685 8.420246e-01 0.075 0 0
Interleukin-1 signaling R-HSA-9020702 8.453985e-01 0.073 0 0
Ion channel transport R-HSA-983712 8.495343e-01 0.071 0 0
Signaling by FGFR2 R-HSA-5654738 8.509577e-01 0.070 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.511475e-01 0.070 0 0
mRNA Capping R-HSA-72086 8.511475e-01 0.070 0 0
Glucagon-type ligand receptors R-HSA-420092 8.511475e-01 0.070 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.512682e-01 0.070 0 0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 8.552168e-01 0.068 0 0
Translesion synthesis by POLI R-HSA-5656121 8.552168e-01 0.068 0 0
Killing mechanisms R-HSA-9664420 8.552168e-01 0.068 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.552168e-01 0.068 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.552168e-01 0.068 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.552168e-01 0.068 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.552168e-01 0.068 0 0
Attachment and Entry R-HSA-9678110 8.552168e-01 0.068 0 0
Regulated Necrosis R-HSA-5218859 8.563703e-01 0.067 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.605309e-01 0.065 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.618909e-01 0.065 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.618909e-01 0.065 0 0
TNF signaling R-HSA-75893 8.646829e-01 0.063 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.646829e-01 0.063 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.646829e-01 0.063 0 0
Translesion synthesis by POLK R-HSA-5655862 8.685602e-01 0.061 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.685602e-01 0.061 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.685602e-01 0.061 0 0
Passive transport by Aquaporins R-HSA-432047 8.685602e-01 0.061 0 0
Coenzyme A biosynthesis R-HSA-196783 8.685602e-01 0.061 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.685602e-01 0.061 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.685602e-01 0.061 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.685602e-01 0.061 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.685602e-01 0.061 0 0
Signaling by FGFR4 R-HSA-5654743 8.692832e-01 0.061 0 0
Integration of energy metabolism R-HSA-163685 8.713506e-01 0.060 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.719193e-01 0.060 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.719193e-01 0.060 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.719193e-01 0.060 0 0
Cargo concentration in the ER R-HSA-5694530 8.719193e-01 0.060 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.719193e-01 0.060 0 0
Developmental Cell Lineages R-HSA-9734767 8.719303e-01 0.060 0 0
IRS-mediated signalling R-HSA-112399 8.723515e-01 0.059 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.759477e-01 0.058 0 0
Immune System R-HSA-168256 8.759766e-01 0.058 0 0
Amine ligand-binding receptors R-HSA-375280 8.775468e-01 0.057 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.792130e-01 0.056 0 0
Dual incision in TC-NER R-HSA-6782135 8.796421e-01 0.056 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.796421e-01 0.056 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.806746e-01 0.055 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 8.806746e-01 0.055 0 0
Sulfide oxidation to sulfate R-HSA-1614517 8.806746e-01 0.055 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.806746e-01 0.055 0 0
Choline catabolism R-HSA-6798163 8.806746e-01 0.055 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.812731e-01 0.055 0 0
Platelet homeostasis R-HSA-418346 8.814212e-01 0.055 0 0
Signaling by FGFR3 R-HSA-5654741 8.853430e-01 0.053 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.865684e-01 0.052 0 0
Recycling of bile acids and salts R-HSA-159418 8.899915e-01 0.051 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.899915e-01 0.051 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.899915e-01 0.051 0 0
Cardiogenesis R-HSA-9733709 8.899915e-01 0.051 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.902653e-01 0.050 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.902653e-01 0.050 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.903082e-01 0.050 0 0
Parasite infection R-HSA-9664407 8.903082e-01 0.050 0 0
Leishmania phagocytosis R-HSA-9664417 8.903082e-01 0.050 0 0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 8.916732e-01 0.050 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.916732e-01 0.050 0 0
Apoptotic factor-mediated response R-HSA-111471 8.916732e-01 0.050 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 8.916732e-01 0.050 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.916732e-01 0.050 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.916732e-01 0.050 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.926928e-01 0.049 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.926928e-01 0.049 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.926928e-01 0.049 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.938282e-01 0.049 0 0
Signaling by FGFR in disease R-HSA-1226099 8.961950e-01 0.048 0 0
MAP kinase activation R-HSA-450294 8.993830e-01 0.046 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.013518e-01 0.045 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.013518e-01 0.045 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.016585e-01 0.045 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.016585e-01 0.045 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.016585e-01 0.045 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.016585e-01 0.045 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.016585e-01 0.045 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.016585e-01 0.045 0 0
Diseases of hemostasis R-HSA-9671793 9.016585e-01 0.045 0 0
Signaling by PDGF R-HSA-186797 9.052982e-01 0.043 0 0
Signal amplification R-HSA-392518 9.056712e-01 0.043 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.056712e-01 0.043 0 0
Intraflagellar transport R-HSA-5620924 9.061357e-01 0.043 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.107240e-01 0.041 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.107240e-01 0.041 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.107240e-01 0.041 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.107240e-01 0.041 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.107240e-01 0.041 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.107240e-01 0.041 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.107240e-01 0.041 0 0
Signaling by NODAL R-HSA-1181150 9.107240e-01 0.041 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.107240e-01 0.041 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.107240e-01 0.041 0 0
Pregnenolone biosynthesis R-HSA-196108 9.107240e-01 0.041 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.109032e-01 0.041 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.127030e-01 0.040 0 0
Metabolism of proteins R-HSA-392499 9.137755e-01 0.039 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.189542e-01 0.037 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.189542e-01 0.037 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.189542e-01 0.037 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.189542e-01 0.037 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.189542e-01 0.037 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.189542e-01 0.037 0 0
Signalling to RAS R-HSA-167044 9.189542e-01 0.037 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.189542e-01 0.037 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.192406e-01 0.037 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.192406e-01 0.037 0 0
RUNX2 regulates bone development R-HSA-8941326 9.192406e-01 0.037 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.222165e-01 0.035 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.253153e-01 0.034 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.264262e-01 0.033 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.264262e-01 0.033 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.264262e-01 0.033 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.264262e-01 0.033 0 0
Serine metabolism R-HSA-977347 9.264262e-01 0.033 0 0
Glutathione synthesis and recycling R-HSA-174403 9.264262e-01 0.033 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.264262e-01 0.033 0 0
Attachment and Entry R-HSA-9694614 9.264262e-01 0.033 0 0
Ribavirin ADME R-HSA-9755088 9.264262e-01 0.033 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.276369e-01 0.033 0 0
Neuronal System R-HSA-112316 9.285178e-01 0.032 0 0
Interferon alpha/beta signaling R-HSA-909733 9.294298e-01 0.032 0 0
Elastic fibre formation R-HSA-1566948 9.309568e-01 0.031 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.331312e-01 0.030 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.332097e-01 0.030 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.332097e-01 0.030 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.332097e-01 0.030 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.332097e-01 0.030 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.332097e-01 0.030 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.332097e-01 0.030 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.332097e-01 0.030 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.332097e-01 0.030 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.332097e-01 0.030 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.332097e-01 0.030 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.351211e-01 0.029 0 0
Collagen formation R-HSA-1474290 9.351211e-01 0.029 0 0
Pentose phosphate pathway R-HSA-71336 9.361934e-01 0.029 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.379426e-01 0.028 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.379426e-01 0.028 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.393681e-01 0.027 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.393681e-01 0.027 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.393681e-01 0.027 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.393681e-01 0.027 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.393681e-01 0.027 0 0
Carnitine shuttle R-HSA-200425 9.393681e-01 0.027 0 0
Transmission across Chemical Synapses R-HSA-112315 9.402929e-01 0.027 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.410517e-01 0.026 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.410517e-01 0.026 0 0
Hemostasis R-HSA-109582 9.414167e-01 0.026 0 0
Post-translational protein modification R-HSA-597592 9.418457e-01 0.026 0 0
Interleukin-17 signaling R-HSA-448424 9.425110e-01 0.026 0 0
Stimuli-sensing channels R-HSA-2672351 9.431812e-01 0.025 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.449590e-01 0.025 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.449590e-01 0.025 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.449590e-01 0.025 0 0
Interleukin-6 family signaling R-HSA-6783589 9.449590e-01 0.025 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.450611e-01 0.025 0 0
Potassium Channels R-HSA-1296071 9.450611e-01 0.025 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.455570e-01 0.024 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.455570e-01 0.024 0 0
Signaling by FGFR1 R-HSA-5654736 9.459339e-01 0.024 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.460791e-01 0.024 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.494031e-01 0.023 0 0
HIV Transcription Initiation R-HSA-167161 9.497330e-01 0.022 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.497330e-01 0.022 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.497330e-01 0.022 0 0
G protein gated Potassium channels R-HSA-1296059 9.500347e-01 0.022 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.500347e-01 0.022 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.500347e-01 0.022 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.500347e-01 0.022 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.500347e-01 0.022 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.500347e-01 0.022 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.500347e-01 0.022 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.500347e-01 0.022 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.500347e-01 0.022 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.500347e-01 0.022 0 0
Laminin interactions R-HSA-3000157 9.500347e-01 0.022 0 0
Signaling by FGFR R-HSA-190236 9.509068e-01 0.022 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.516549e-01 0.022 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.527682e-01 0.021 0 0
Activation of GABAB receptors R-HSA-991365 9.536022e-01 0.021 0 0
GABA B receptor activation R-HSA-977444 9.536022e-01 0.021 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.540044e-01 0.020 0 0
MET activates PTK2 signaling R-HSA-8874081 9.546426e-01 0.020 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.546426e-01 0.020 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.546426e-01 0.020 0 0
Metalloprotease DUBs R-HSA-5689901 9.546426e-01 0.020 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.546426e-01 0.020 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.546426e-01 0.020 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.560397e-01 0.020 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.562999e-01 0.019 0 0
Regulation of beta-cell development R-HSA-186712 9.562999e-01 0.019 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.565040e-01 0.019 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.571856e-01 0.019 0 0
Pyrimidine catabolism R-HSA-73621 9.571856e-01 0.019 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.571856e-01 0.019 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.580970e-01 0.019 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.588258e-01 0.018 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.588258e-01 0.018 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.588258e-01 0.018 0 0
Signaling by BMP R-HSA-201451 9.588258e-01 0.018 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.588258e-01 0.018 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.588258e-01 0.018 0 0
tRNA Aminoacylation R-HSA-379724 9.593198e-01 0.018 0 0
Gap junction trafficking R-HSA-190828 9.605029e-01 0.018 0 0
PI Metabolism R-HSA-1483255 9.609457e-01 0.017 0 0
Collagen degradation R-HSA-1442490 9.621429e-01 0.017 0 0
Endogenous sterols R-HSA-211976 9.621429e-01 0.017 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.626234e-01 0.017 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.626234e-01 0.017 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.626234e-01 0.017 0 0
Pyrimidine salvage R-HSA-73614 9.626234e-01 0.017 0 0
Prednisone ADME R-HSA-9757110 9.626234e-01 0.017 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.626234e-01 0.017 0 0
Pyroptosis R-HSA-5620971 9.626234e-01 0.017 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.631107e-01 0.016 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.635489e-01 0.016 0 0
Translation of Structural Proteins R-HSA-9694635 9.635489e-01 0.016 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.635728e-01 0.016 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.647810e-01 0.016 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.647810e-01 0.016 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.660709e-01 0.015 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.660709e-01 0.015 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.660709e-01 0.015 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.660709e-01 0.015 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.664126e-01 0.015 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.664126e-01 0.015 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.664126e-01 0.015 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.680905e-01 0.014 0 0
SLC transporter disorders R-HSA-5619102 9.682614e-01 0.014 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.689628e-01 0.014 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.690388e-01 0.014 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.692007e-01 0.014 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.692007e-01 0.014 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.692007e-01 0.014 0 0
Extracellular matrix organization R-HSA-1474244 9.699400e-01 0.013 0 0
PPARA activates gene expression R-HSA-1989781 9.702507e-01 0.013 0 0
Metal ion SLC transporters R-HSA-425410 9.714664e-01 0.013 0 0
Mitochondrial protein degradation R-HSA-9837999 9.719068e-01 0.012 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.720419e-01 0.012 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.720419e-01 0.012 0 0
Gap junction trafficking and regulation R-HSA-157858 9.737098e-01 0.012 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.737098e-01 0.012 0 0
tRNA processing R-HSA-72306 9.738376e-01 0.012 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.741259e-01 0.011 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.746211e-01 0.011 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.755641e-01 0.011 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.756310e-01 0.011 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.757824e-01 0.011 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.769626e-01 0.010 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.773057e-01 0.010 0 0
The phototransduction cascade R-HSA-2514856 9.776964e-01 0.010 0 0
Formation of the cornified envelope R-HSA-6809371 9.790394e-01 0.009 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.790882e-01 0.009 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.790882e-01 0.009 0 0
Heme degradation R-HSA-189483 9.790882e-01 0.009 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.795642e-01 0.009 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.795642e-01 0.009 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.795642e-01 0.009 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.808764e-01 0.008 0 0
eNOS activation R-HSA-203615 9.810177e-01 0.008 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.810177e-01 0.008 0 0
Hyaluronan metabolism R-HSA-2142845 9.810177e-01 0.008 0 0
Nucleotide biosynthesis R-HSA-8956320 9.810947e-01 0.008 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.814757e-01 0.008 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.814757e-01 0.008 0 0
Parasitic Infection Pathways R-HSA-9824443 9.815162e-01 0.008 0 0
Leishmania infection R-HSA-9658195 9.815162e-01 0.008 0 0
Toll-like Receptor Cascades R-HSA-168898 9.819445e-01 0.008 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.827693e-01 0.008 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.827693e-01 0.008 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.827693e-01 0.008 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.827693e-01 0.008 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.827693e-01 0.008 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.829428e-01 0.007 0 0
Glycosphingolipid transport R-HSA-9845576 9.843594e-01 0.007 0 0
GPVI-mediated activation cascade R-HSA-114604 9.843594e-01 0.007 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.843594e-01 0.007 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.843793e-01 0.007 0 0
Aspirin ADME R-HSA-9749641 9.843793e-01 0.007 0 0
Signaling by ERBB4 R-HSA-1236394 9.855143e-01 0.006 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.855143e-01 0.006 0 0
NCAM1 interactions R-HSA-419037 9.858028e-01 0.006 0 0
Voltage gated Potassium channels R-HSA-1296072 9.858028e-01 0.006 0 0
Collagen chain trimerization R-HSA-8948216 9.858028e-01 0.006 0 0
Metabolism of folate and pterines R-HSA-196757 9.858028e-01 0.006 0 0
Iron uptake and transport R-HSA-917937 9.865700e-01 0.006 0 0
Peptide hormone metabolism R-HSA-2980736 9.868060e-01 0.006 0 0
RSV-host interactions R-HSA-9833110 9.870546e-01 0.006 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.871131e-01 0.006 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.871131e-01 0.006 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.871131e-01 0.006 0 0
G alpha (s) signalling events R-HSA-418555 9.876562e-01 0.005 0 0
IRE1alpha activates chaperones R-HSA-381070 9.878154e-01 0.005 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.879531e-01 0.005 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.883026e-01 0.005 0 0
RAS processing R-HSA-9648002 9.883026e-01 0.005 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.883638e-01 0.005 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.883638e-01 0.005 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.886467e-01 0.005 0 0
Integrin cell surface interactions R-HSA-216083 9.893117e-01 0.005 0 0
Cholesterol biosynthesis R-HSA-191273 9.893117e-01 0.005 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.893823e-01 0.005 0 0
Tryptophan catabolism R-HSA-71240 9.893823e-01 0.005 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.894237e-01 0.005 0 0
GABA receptor activation R-HSA-977443 9.894642e-01 0.005 0 0
RAB geranylgeranylation R-HSA-8873719 9.894642e-01 0.005 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.903791e-01 0.004 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.903791e-01 0.004 0 0
Gastrulation R-HSA-9758941 9.909945e-01 0.004 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.912521e-01 0.004 0 0
Translation of Structural Proteins R-HSA-9683701 9.912521e-01 0.004 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.913285e-01 0.004 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.920597e-01 0.003 0 0
Xenobiotics R-HSA-211981 9.924853e-01 0.003 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.927928e-01 0.003 0 0
Protein localization R-HSA-9609507 9.928916e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.934582e-01 0.003 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.936006e-01 0.003 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.940623e-01 0.003 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.950612e-01 0.002 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.951083e-01 0.002 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.954683e-01 0.002 0 0
COPII-mediated vesicle transport R-HSA-204005 9.954938e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.955601e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.958640e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.959701e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.961088e-01 0.002 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.961088e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.962043e-01 0.002 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.963423e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.966802e-01 0.001 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.979856e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.981443e-01 0.001 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.982568e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.984714e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.986127e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.987409e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.989629e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.989675e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.990588e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.992248e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.992964e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.992964e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.992964e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.993378e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.993615e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.993788e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.994741e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.995228e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.995228e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.995228e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.995552e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.995719e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.996403e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.996763e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.997129e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997278e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.997581e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.997805e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.997805e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.997961e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.997961e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998192e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.998873e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999095e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999285e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999378e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999379e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999653e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999685e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999685e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999708e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999741e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999756e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999817e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999827e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999838e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999841e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999869e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999871e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999875e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999902e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999915e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999919e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999931e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999932e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999940e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999944e-01 0.000 1 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999963e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999973e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999980e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999985e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999986e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999986e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999994e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999995e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999995e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999997e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999997e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999999e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999999e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways