PKCT

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A0MZ66 S375 Sugiyama SHTN1 KIAA1598 PPPPPPPLPPPPPNPIRSLMsMIRKRSHPSGSGAKKEKATQ
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974 T853 PSP PPP1R12A MBS MYPT1 DKSQPKSIRERRRPREKRRstGVSFWtQDsDENEQEQQsDt
O15111 S176 iPTMNet CHUK IKKA TCF16 GGKIIHKIIDLGYAKDVDQGsLCTsFVGTLQYLAPELFENK
O15111 S180 iPTMNet CHUK IKKA TCF16 IHKIIDLGYAKDVDQGsLCTsFVGTLQYLAPELFENKPYTA
O15371 T49 Sugiyama EIF3D EIF3S7 PyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGGSQY
O15530 S241 PSP PDPK1 PDK1 ITDFGTAKVLSPESKQARANsFVGtAQYVSPELLTEKSACK
O15530 S64 PSP PDPK1 PDK1 GSRQGPAMDGTAAEPRPGAGsLQHAQPPPQPRKKRPEDFKF
O43516 S488 SIGNOR|ELM|iPTMNet|PSP WIPF1 WASPIP WIP YVQTTKSYPSKLARNESRSGsNRRERGAPPLPPIPR_____
O60220 S94 Sugiyama TIMM8A DDP DDP1 TIM8A SQFILNRLEQTQKSKPVFSEsLsD_________________
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S196 Sugiyama EIF5B IF2 KIAA0741 ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O60841 T78 Sugiyama EIF5B IF2 KIAA0741 ILKELEELsLEAQGIKADREtVAVKPTENNEEEFtsKDKKK
O75369 S1442 Sugiyama FLNB FLN1L FLN3 TABP TAP SKVKIAGPGLGsGVRARVLQsFtVDSSKAGLAPLEVRVLGP
O75369 S2532 Sugiyama FLNB FLN1L FLN3 TABP TAP ASKVTSKGAGLSKAFVGQKssFLVDCSKAGSNMLLIGVHGP
O94992 S158 PSP HEXIM1 CLP1 EDG1 HIS1 MAQ1 EEEWGQQQRQLGKKKHRRRPsKKKRHWKPYYKLTWEEKKKF
O94992 T270 Sugiyama HEXIM1 CLP1 EDG1 HIS1 MAQ1 GGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELIKE
O95267 T184 PSP RASGRP1 RASGRP LHCRLIDTTQINARDWSRKLtQRIKSNTSKKRKVSLLFDHL
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95816 S208 Sugiyama BAG2 IKLLEHSKGAGSKTLQQNAEsRFN_________________
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 S167 Sugiyama LDHA PIG19 AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG
P00558 S174 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558 S175 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S86 Sugiyama HSPB1 HSP27 HSP28 PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP
P05362 S43 Sugiyama ICAM1 GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05455 S325 Sugiyama SSB VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05783 S93 Sugiyama KRT18 CYK18 PIG46 GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787 S410 Sugiyama KRT8 CYK8 TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S168 Sugiyama LDHB TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07437 S75 Sugiyama TUBB TUBB5 OK/SW-cl.56 tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07602 S29 Sugiyama PSAP GLBA SAP1 SLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVKHCL
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07814 T1506 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 LCELQPGAKCVCGKNPAKyytLFGRsy______________
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07864 S167 Sugiyama LDHC LDH3 LDHX VWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVHPTSCHG
P08195 S253 Sugiyama SLC3A2 MDU1 FQGHGAGNLAGLKGRLDyLssLKVKGLVLGPIHKNQKDDVA
P08195 S296 Sugiyama SLC3A2 MDU1 DLLQIDPNFGsKEDFDsLLQsAKKKSIRVILDLTPNYRGEN
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09234 S17 Sugiyama SNRPC ____MPKFyCDyCDtyLtHDsPsVRKTHCSGRKHKENVKDY
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09651 S360 Sugiyama HNRNPA1 HNRPA1 PyGGGGQyFAKPRNQGGyGGssssssyGsGRRF________
P09651 S368 Sugiyama HNRNPA1 HNRPA1 FAKPRNQGGyGGssssssyGsGRRF________________
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09651 Y366 Sugiyama HNRNPA1 HNRPA1 QyFAKPRNQGGyGGssssssyGsGRRF______________
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7 T334 Sugiyama TUBA3C TUBA2 ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
P10588 S83 PSP NR2F6 EAR2 ERBAL2 SSGKHYGVFTCEGCKSFFKRsIRRNLSYTCRSNRDCQIDQH
P10809 S488 Sugiyama HSPD1 HSP60 IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P10809 S67 Sugiyama HSPD1 HSP60 LADAVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLK
P10809 S83 Sugiyama HSPD1 HSP60 IIEQsWGsPKVTKDGVtVAKsIDLKDKYKNIGAKLVQDVAN
P10809 T105 Sugiyama HSPD1 HSP60 DLKDKYKNIGAKLVQDVANNtNEEAGDGtttAtVLARSIAK
P10809 T117 Sugiyama HSPD1 HSP60 LVQDVANNtNEEAGDGtttAtVLARSIAKEGFEKISKGANP
P10809 T61 Sugiyama HSPD1 HSP60 LQGVDLLADAVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVA
P10809 T79 Sugiyama HSPD1 HSP60 GRtVIIEQsWGsPKVTKDGVtVAKsIDLKDKYKNIGAKLVQ
P11142 S340 Sugiyama HSPA8 HSC70 HSP73 HSPA10 ALRDAKLDKsQIHDIVLVGGstRIPKIQKLLQDFFNGKELN
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T47 Sugiyama HSPA8 HSC70 HSP73 HSPA10 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtNtV
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11586 T128 Sugiyama MTHFD1 MTHFC MTHFD SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639 S732 Sugiyama EEF2 EF2 DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618 S205 Sugiyama PKM OIP3 PK2 PK3 PKM2 VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14618 T45 Sugiyama PKM OIP3 PK2 PK3 PKM2 TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P14625 S172 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI
P14625 S515 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14625 S680 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 RIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLIRDMLRR
P15311 T567 PSP EZR VIL2 RTHNDIIHNENMRQGRDKYKtLRQIRQGNTKQRIDEFEAL_
P15407 S265 PSP FOSL1 FRA1 ASAHRKsssssGDPSsDPLGsPtLLAL______________
P15407 T217 SIGNOR FOSL1 FRA1 RPVPCISLSPGPVLEPEALHtPTLMTtPSLtPFtPSLVFTY
P15407 T223 PSP FOSL1 FRA1 SLSPGPVLEPEALHtPTLMTtPSLtPFtPSLVFTYPStPEP
P15407 T227 SIGNOR FOSL1 FRA1 GPVLEPEALHtPTLMTtPSLtPFtPSLVFTYPStPEPCASA
P15407 T230 PSP FOSL1 FRA1 LEPEALHtPTLMTtPSLtPFtPSLVFTYPStPEPCASAHRK
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 T49 Sugiyama HSPA6 HSP70B' EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P17987 S374 Sugiyama TCP1 CCT1 CCTA ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18669 S155 Sugiyama PGAM1 PGAMA CDABP0006 NIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQI
P18669 T159 Sugiyama PGAM1 PGAMA CDABP0006 DRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQIKEGK
P18858 S901 Sugiyama LIG1 DKQPEQATTSAQVACLYRKQsQIQNQQGEDsGsDPEDTY__
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20618 S162 Sugiyama PSMB1 PSC5 DEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLDNQVG
P20618 Y158 Sugiyama PSMB1 PSC5 IGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLD
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23526 S183 Sugiyama AHCY SAHH NLyKMMANGILKVPAINVNDsVtKsKFDNLyGCRESLIDGI
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P25205 S447 Sugiyama MCM3 EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25705 S198 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM GIIPRIsVREPMQTGIKAVDsLVPIGRGQRELIIGDRQTGK
P25789 S7 Sugiyama PSMA4 HC9 PSC9 ______________MSRRyDsRttIFsPEGRLYQVEYAMEA
P25789 Y5 Sugiyama PSMA4 HC9 PSC9 ________________MSRRyDsRttIFsPEGRLYQVEYAM
P26038 T558 SIGNOR|iPTMNet|PSP MSN KTANDMIHAENMRLGRDKYKtLRQIRQGNTKQRIDEFEsM_
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T24 Sugiyama RPL13 BBC1 OK/SW-cl.46 SRNGMVLKPHFHKDWQRRVAtWFNQPARKIRRRKARQAKAR
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27348 S63 Sugiyama YWHAQ LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29350 S591 SIGNOR|PSP PTPN6 HCP PTP1C NKREEKVKKQRSADKEKSKGsLKRK________________
P29474 T495 SIGNOR NOS3 YQPDPWKGSAAKGTGITRKKtFKEVANAVKISASLMGTVMA
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692 S60 Sugiyama EEF1D EF1D ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P29692 S64 Sugiyama EEF1D EF1D sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31327 S898 Sugiyama CPS1 LYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQIS
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31946 S65 Sugiyama YWHAB LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P32119 S112 Sugiyama PRDX2 NKEFB TDPX1 KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P32942 S518 SIGNOR|ELM|iPTMNet|PSP ICAM3 GVVTIVLALMYVFREHQRsGsYHVREEstyLPLTSMQPTEA
P33176 S57 Sugiyama KIF5B KNS KNS1 DTVVIASKPYAFDRVFQSsTsQEQVyNDCAKKIVKDVLEGy
P33316 S120 Sugiyama DUT PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33316 S130 Sugiyama DUT GGMQLRFARLsEHAtAPTRGsARAAGYDLYSAYDYTIPPME
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 T49 Sugiyama HSPA1L EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQNTV
P35236 S246 SIGNOR|PSP PTPN7 KECPEYTVRQLTIQYQEERRsVKHILFSAWPDHQTPESAGP
P35236 S44 PSP PTPN7 QPPPEKTPAKKHVRLQERRGsNVALMLDVRSLGAVEPICsV
P35241 T564 PSP RDX KTQNDVLHAENVKAGRDKYKtLRQIRQGNtKQRIDEFEAM_
P35568 S1101 SIGNOR|ELM|iPTMNet|PSP IRS1 RNQSAKVIRADPQGCRRRHssEtFsstPSATRVGNTVPFGA
P35579 T1906 Sugiyama MYH9 AQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRGDL
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578 S87 Sugiyama RPL4 RPL1 WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578 T84 Sugiyama RPL4 RPL1 AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P37108 S25 Sugiyama SRP14 EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37235 T149 PSP HPCAL1 BDR1 YKMVSSVMKMPEDEstPEKRtDKIFRQMDTNNDGKLSLEEF
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646 S200 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 NyLGHtAKNAVItVPAyFNDsQRQAtKDAGQIsGLNVLRVI
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39019 S96 Sugiyama RPS19 TKIYGGRQRNGVMPsHFsRGsKsVARRVLQALEGLKMVEKD
P39019 S98 Sugiyama RPS19 IYGGRQRNGVMPsHFsRGsKsVARRVLQALEGLKMVEKDQD
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P41594 S840 SIGNOR|iPTMNet GRM5 GPRC1E MGLUR5 PKVYIILAKPERNVRSAFTTstVVRMHVGDGKSSSAASRSS
P41594 T841 SIGNOR GRM5 GPRC1E MGLUR5 KVYIILAKPERNVRSAFTTstVVRMHVGDGKSSSAASRSSS
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46060 S24 Sugiyama RANGAP1 KIAA1835 SD EDIAKLAETLAKTQVAGGQLsFKGKSLKLNTAEDAKDVIKE
P46060 S504 PSP RANGAP1 KIAA1835 SD ATVRMAVQDAVDALMQKAFNsSsFNSNTFLTRLLVHMGLLK
P46060 S506 PSP RANGAP1 KIAA1835 SD VRMAVQDAVDALMQKAFNsSsFNSNTFLTRLLVHMGLLKSE
P46777 S172 Sugiyama RPL5 MSTP030 RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46777 T177 Sugiyama RPL5 MSTP030 NKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHRK
P46779 S115 Sugiyama RPL28 HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47756 S192 Sugiyama CAPZB TVMLWLQTNKSGsGtMNLGGsLtRQMEKDEtVsDCsPHIAN
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48739 S165 Sugiyama PITPNB DRSQVEPADyKADEDPALFQsVKtKRGPLGPNWKKELANsP
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 T49 Sugiyama HSPA7 HSP70B EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P49588 S775 Sugiyama AARS1 AARS VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P49792 S1456 Sugiyama RANBP2 NUP358 IACQNTKsANKsGssFVHQAsFKFGQGDLPKPINSDFRSVF
P50991 T50 Sugiyama CCT4 CCTD SRB PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116 S603 Sugiyama FXR2 FMR1L2 QRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQsR
P51991 S375 Sugiyama HNRNPA3 HNRPA3 ssGsPyGGGyGsGGGsGGyGsRRF_________________
P52789 S415 Sugiyama HK2 QRIKENKGEERLRstIGVDGsVyKKHPHFAKRLHKTVRRLV
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396 S459 Sugiyama ACLY LNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMPQDsV
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T48 Sugiyama HSPA2 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTNTI
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61513 S21 Sugiyama RPL37A MAKRTKKVGIVGKyGtRYGAsLRKMVKKIEISQHAKYTCSF
P61513 T16 Sugiyama RPL37A _____MAKRTKKVGIVGKyGtRYGAsLRKMVKKIEISQHAK
P61513 Y14 Sugiyama RPL37A _______MAKRTKKVGIVGKyGtRYGAsLRKMVKKIEISQH
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978 S420 Sugiyama HNRNPK HNRPK GsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITItGt
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981 S64 Sugiyama YWHAG LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62304 S89 Sugiyama SNRPE KSRKQLGRIMLKGDNITLLQsVsN_________________
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62805 S48 Sugiyama H4C1 H4/A H4FA HIST1H4A; H4C2 H4/I H4FI HIST1H4B; H4C3 H4/G H4FG HIST1H4C; H4C4 H4/B H4FB HIST1H4D; H4C5 H4/J H4FJ HIST1H4E; H4C6 H4/C H4FC HIST1H4F; H4C8 H4/H H4FH HIST1H4H; H4C9 H4/M H4FM HIST1H4I; H4C11 H4/E H4FE HIST1H4J; H4C12 H4/D H4FD HIST1H4K; H4C13 H4/K H4FK HIST1H4L; H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A; H4C15 H4/O H4FO HIST2H4B; H4C16 H4-16 HIST4H4 QGItKPAIRRLARRGGVKRIsGLIyEETRGVLKVFLENVIR
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62913 S59 Sugiyama RPL11 VLEQLtGQtPVFsKARyTVRsFGIRRNEKIAVHCTVRGAKA
P62913 Y55 Sugiyama RPL11 RAAKVLEQLtGQtPVFsKARyTVRsFGIRRNEKIAVHCTVR
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S138 Sugiyama RPL8 EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 T143 Sugiyama RPL8 RGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANR
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62937 S51 Sugiyama PPIA CYPA KtAENFRALSTGEKGFGYKGsCFHRIIPGFMCQGGDFtRHN
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 T334 Sugiyama TUBA1B ACCLLyRGDVVPKDVNAAIAtIKtKRsIQFVDWCPTGFKVG
P78371 S60 Sugiyama CCT2 99D8.1 CCTB KSTLGPKGMDKILLsSGRDAsLMVtNDGAtILKNIGVDNPA
P78371 T69 Sugiyama CCT2 99D8.1 CCTB DKILLsSGRDAsLMVtNDGAtILKNIGVDNPAAKVLVDMSR
P78417 S23 Sugiyama GSTO1 GSTTLP28 GESARsLGKGsAPPGPVPEGsIRIySMRFCPFAERTRLVLK
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S7 Sugiyama RPL24 ______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T52 Sugiyama RPL24 LNAKCEsAFLSKRNPRQINWtVLyRRKHKKGQsEEIQKKRT
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00341 S904 Sugiyama HDLBP HBP VGL FHRSVMGPKGSRIQQITRDFsVQIKFPDREENAVHSTEPVV
Q00610 S146 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 AVYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLL
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q04759 S216 Sugiyama PRKCQ PRKCT AIHKKCIDKVIAKCTGSAINsREtMFHKERFKIDMPHRFKV
Q04759 S323 Sugiyama PRKCQ PRKCT CLRDtEQIFREGPVEIGLPCsIKNEARPPCLPTPGKREPQG
Q04759 S345 Sugiyama PRKCQ PRKCT KNEARPPCLPTPGKREPQGIsWEsPLDEVDKMCHLPEPELN
Q04759 S370 Sugiyama PRKCQ PRKCT LDEVDKMCHLPEPELNKERPsLQIKLKIEDFILHKMLGKGS
Q04759 S676 Sugiyama PRKCQ PRKCT KSPFDCSNFDKEFLNEKPRLsFADRALINsMDQNMFRNFsF
Q04759 S685 Sugiyama PRKCQ PRKCT DKEFLNEKPRLsFADRALINsMDQNMFRNFsFMNPGMERLI
Q04759 S695 Sugiyama PRKCQ PRKCT LsFADRALINsMDQNMFRNFsFMNPGMERLIS_________
Q04759 T219 SIGNOR|ELM|iPTMNet|EPSD|PSP|Sugiyama PRKCQ PRKCT KKCIDKVIAKCTGSAINsREtMFHKERFKIDMPHRFKVYNY
Q04759 T307 Sugiyama PRKCQ PRKCT LMAEALAMIESTQQARCLRDtEQIFREGPVEIGLPCsIKNE
Q04759 T542 Sugiyama PRKCQ PRKCT DFGMCKENMLGDAKtNtFCGtPDyIAPEILLGQKYNHSVDW
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q04917 S64 Sugiyama YWHAH YWHA1 LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06830 S126 Sugiyama PRDX1 PAGA PAGB TDPX2 SDPKRtIAQDyGVLKADEGIsFRGLFIIDDKGILRQItVND
Q06830 S30 Sugiyama PRDX1 PAGA PAGB TDPX2 HPAPNFKAtAVMPDGQFKDIsLsDyKGKYVVFFFYPLDFTF
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q06830 T18 Sugiyama PRDX1 PAGA PAGB TDPX2 ___MSSGNAKIGHPAPNFKAtAVMPDGQFKDIsLsDyKGKY
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07352 S84 Sugiyama ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B QNQLLSsLKGEPAPALSSRDsRFRDRsFsEGGERLLPTQKQ
Q12965 T936 Sugiyama MYO1E MYO1C LQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAP
Q13191 S282 PSP CBLB RNF56 Nbla00127 AFLTYDEVKARLQKYSTKPGsYIFRLSCTRLGQWAIGYVTG
Q13509 S75 Sugiyama TUBB3 TUBB4 SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13885 S75 Sugiyama TUBB2A TUBB2 AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q14152 S1028 Sugiyama EIF3A EIF3S10 KIAA0139 NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152 S988 Sugiyama EIF3A EIF3S10 KIAA0139 PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14157 S852 Sugiyama UBAP2L KIAA0144 NICE4 LDyysIPFPtPttPLtGRDGsLAsNPysGDLtKFGRGDASS
Q14498 S337 Sugiyama RBM39 HCC1 RNPC2 AGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGRL
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15052 S225 SIGNOR|PSP ARHGEF6 COOL2 KIAA0006 PIXA RTGWFPSNYVREIKSSERPLsPKAVKGFETAPLTKNYYTVV
Q15052 S488 SIGNOR|PSP ARHGEF6 COOL2 KIAA0006 PIXA ERYLMLFSNVLIMLSASPRMsGFIYQGKIPIAGTVVTRLDE
Q15334 S655 PSP LLGL1 DLG4 HUGL HUGL1 RCTLHPNDSLAMEGPLSRVKsLKKsLRQsFRRIRKsRVsGK
Q15334 S659 PSP LLGL1 DLG4 HUGL HUGL1 HPNDSLAMEGPLSRVKsLKKsLRQsFRRIRKsRVsGKKRAA
Q15334 S663 PSP LLGL1 DLG4 HUGL HUGL1 SLAMEGPLSRVKsLKKsLRQsFRRIRKsRVsGKKRAANAss
Q15334 S670 PSP LLGL1 DLG4 HUGL HUGL1 LSRVKsLKKsLRQsFRRIRKsRVsGKKRAANAssKLQEANA
Q15334 S673 PSP LLGL1 DLG4 HUGL HUGL1 VKsLKKsLRQsFRRIRKsRVsGKKRAANAssKLQEANAQLA
Q16637 S28 Sugiyama SMN1 SMN SMNT; SMN2 SMNC sGGGVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVA
Q16637 S31 Sugiyama SMN1 SMN SMNT; SMN2 SMNC GVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVAsFK
Q16658 T239 Sugiyama FSCN1 FAN1 HSN SNL GKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALEQs
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q3V6T2 S1690 PSP CCDC88A APE GRDN KIAA1212 KIKtGsPGsEVVTLQQFLEEsNKLTSVQIKsssQENLLDEV
Q3ZCM7 S75 Sugiyama TUBB8 SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC
Q5JVS0 T354 SIGNOR|iPTMNet|PSP HABP4 MVKDDYEDDSHVFRKPANDItSQLEINFGNLPRPGRGARGG
Q5JVS0 T375 SIGNOR|iPTMNet|PSP HABP4 SQLEINFGNLPRPGRGARGGtRGGRGRIRRAENYGPRAEVV
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6PEY2 T334 Sugiyama TUBA3E ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZMR3 S167 Sugiyama LDHAL6A LDHL2 AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG
Q71U36 T334 Sugiyama TUBA1A TUBA3 ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IV61 T133 SIGNOR|ELM|PSP RASGRP3 GRP3 KIAA0846 KHVSLIDISSIPSYDWMRRVtQRKKVSKKGKACLLFDHLEP
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8N684 S166 Sugiyama CPSF7 PGKVLNGEKVDVRPAtRQNLsQFEAQARKRECVRVPRGGIP
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8WVK2 S132 Sugiyama SNRNP27 FDSTKGKKVDGsVNAyAINVsQKRKYRQYMNRKGGFNRPLD
Q92890 S299 Sugiyama UFD1 UFD1L KKVEEDEAGGRFVAFsGEGQsLRKKGRKP____________
Q92934 S75 PSP BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934 S99 PSP BAD BBC6 BCL2L8 GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q969F2 S31 PSP NKD2 AARKRRESPEGDSFVASAYAsGRKGAEEAERRARDKQELPN
Q96IR7 S360 Sugiyama HPDL GLOXD1 LIQRQGATGFGQGNIRALWQsVQEQsARSQEA_________
Q96MH2 T196 Sugiyama HEXIM2 L3 GDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELVRD
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQE3 T334 Sugiyama TUBA1C TUBA6 ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q9BRK5 S99 Sugiyama SDF4 CAB45 PSEC0034 QEVFLGKDLGGFDEDAEPRRsRRKLMVIFSKVDVNTDRKIS
Q9BVA1 S75 Sugiyama TUBB2B tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BXL7 S559 PSP CARD11 CARMA1 CGSLPITNSFTKMQPPRsRssIMsITAEPPGNDsIVRRYKE
Q9BXL7 S644 SIGNOR CARD11 CARMA1 QSEGLDAYDLEQVNLMFRKFsLERPFRPsVtsVGHVRGPGP
Q9BXL7 S893 SIGNOR|PSP CARD11 CARMA1 QPEEALstsDPRVsPRLSRAsFLFGQLLQFVSRSENKYKRM
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9GZT3 S15 Sugiyama SLIRP C14orf156 DC23 DC50 PD04872 ______MAASAARGAAALRRsINQPVAFVRRIPWTAASSQL
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9NPA3 Y91 Sugiyama MID1IP1 MIG12 PDSGsANGsFFAPSRDMYSHyVLLKSIRNDIEWGVLHQPPP
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9UBR2 S78 Sugiyama CTSZ SPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHAST
Q9UEW8 S309 SIGNOR|iPTMNet|PSP STK39 PASK SPAK DPPTLETGVEDKEMMKKYGKsFRKLLsLCLQKDPsKRPTAA
Q9UEW8 S323 SIGNOR|iPTMNet|PSP STK39 PASK SPAK MKKYGKsFRKLLsLCLQKDPsKRPTAAELLKCKFFQKAKNR
Q9UGV2 S327 Sugiyama NDRG3 KYFLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsV
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2 S333 Sugiyama NDRG3 MGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsD
Q9UGV2 T329 Sugiyama NDRG3 FLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVts
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UHD2 S716 SIGNOR|PSP TBK1 NAK EMEGVVKELAENNHILERFGsLtMDGGLRNVDCL_______
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2 S39 Sugiyama ATP5IF1 ATPI ATPIF1 TMQARGFGsDQSENVDRGAGsIREAGGAFGKREQAEEERyF
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y3B8 S203 Sugiyama REXO2 SFN SMFN CGI-114 EYEFAPKKAAsHRALDDIsEsIKELQFyRNNIFKKKIDEKK
Q9Y4G8 S960 SIGNOR|PSP RAPGEF2 KIAA0313 NRAPGEP PDZGEF1 NATVLDVAQTGGHKKRVRRssFLNAKKLYEDAQMARKVKQY
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 9.103829e-15 14.041 1 0
Cell Cycle R-HSA-1640170 9.650672e-10 9.015 0 0
Axon guidance R-HSA-422475 1.269620e-09 8.896 1 0
Cellular Senescence R-HSA-2559583 4.425961e-09 8.354 0 0
Apoptotic execution phase R-HSA-75153 1.860329e-08 7.730 1 0
Nervous system development R-HSA-9675108 3.276415e-08 7.485 1 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.395617e-08 7.357 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 9.545911e-08 7.020 1 1
Cell Cycle, Mitotic R-HSA-69278 4.210288e-07 6.376 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.088310e-07 6.293 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.412703e-06 5.850 0 0
NRAGE signals death through JNK R-HSA-193648 1.686407e-06 5.773 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.522015e-06 5.345 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.906311e-06 5.229 0 0
G alpha (12/13) signalling events R-HSA-416482 7.049950e-06 5.152 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 9.043696e-06 5.044 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.084225e-05 4.965 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.550888e-05 4.809 0 0
Cell Cycle Checkpoints R-HSA-69620 2.308091e-05 4.637 0 0
Mitotic Prometaphase R-HSA-68877 2.608879e-05 4.584 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.712808e-05 4.567 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.407450e-05 4.468 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.706927e-05 4.431 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.706927e-05 4.431 0 0
M Phase R-HSA-68886 4.296269e-05 4.367 0 0
Post NMDA receptor activation events R-HSA-438064 5.413149e-05 4.267 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.959536e-05 4.225 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.203797e-05 4.207 0 0
Diseases of programmed cell death R-HSA-9645723 6.508585e-05 4.187 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 8.501681e-05 4.070 1 1
MAPK family signaling cascades R-HSA-5683057 8.676502e-05 4.062 1 0
Intracellular signaling by second messengers R-HSA-9006925 9.069481e-05 4.042 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.388146e-04 3.858 0 0
L1CAM interactions R-HSA-373760 1.404823e-04 3.852 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.452723e-04 3.838 0 0
Signaling by VEGF R-HSA-194138 1.450070e-04 3.839 0 0
EPH-Ephrin signaling R-HSA-2682334 1.559690e-04 3.807 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.506998e-04 3.822 0 0
Chromatin modifying enzymes R-HSA-3247509 1.582540e-04 3.801 0 0
Meiosis R-HSA-1500620 1.644892e-04 3.784 0 0
Death Receptor Signaling R-HSA-73887 1.876620e-04 3.727 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.877705e-04 3.726 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.257660e-04 3.646 0 0
Chromatin organization R-HSA-4839726 2.406550e-04 3.619 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.528852e-04 3.597 0 0
Apoptosis R-HSA-109581 2.654847e-04 3.576 1 0
Rap1 signalling R-HSA-392517 2.792143e-04 3.554 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.196611e-04 3.495 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.437413e-04 3.464 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.361769e-04 3.473 0 0
Meiotic synapsis R-HSA-1221632 3.570700e-04 3.447 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.530693e-04 3.452 1 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.999229e-04 3.398 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.128785e-04 3.384 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.661503e-04 3.331 0 0
Signaling by Hippo R-HSA-2028269 4.925916e-04 3.308 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.146630e-04 3.288 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.005458e-04 3.301 0 0
FOXO-mediated transcription R-HSA-9614085 5.434723e-04 3.265 0 0
Kinesins R-HSA-983189 5.924731e-04 3.227 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.056710e-04 3.151 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.792577e-04 3.108 0 0
Cellular responses to stimuli R-HSA-8953897 7.959179e-04 3.099 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.763714e-04 3.010 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 9.537251e-04 3.021 0 0
mRNA Splicing R-HSA-72172 9.593503e-04 3.018 0 0
Semaphorin interactions R-HSA-373755 1.022966e-03 2.990 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.051813e-03 2.978 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.031258e-03 2.987 0 0
Metalloprotease DUBs R-HSA-5689901 1.074409e-03 2.969 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.170066e-03 2.932 0 0
Regulation of TP53 Activity R-HSA-5633007 1.213061e-03 2.916 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.213553e-03 2.916 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.165911e-03 2.933 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.286581e-03 2.891 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.286581e-03 2.891 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.286581e-03 2.891 0 0
Signaling by RAS mutants R-HSA-6802949 1.286581e-03 2.891 0 0
Neuronal System R-HSA-112316 1.242697e-03 2.906 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.259133e-03 2.900 1 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.440743e-03 2.841 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.502237e-03 2.823 0 0
ESR-mediated signaling R-HSA-8939211 1.564197e-03 2.806 0 0
Recycling pathway of L1 R-HSA-437239 1.567134e-03 2.805 0 0
mRNA 3'-end processing R-HSA-72187 1.706069e-03 2.768 0 0
Mitotic Anaphase R-HSA-68882 1.729458e-03 2.762 0 0
Programmed Cell Death R-HSA-5357801 1.733283e-03 2.761 1 0
RAF/MAP kinase cascade R-HSA-5673001 1.748689e-03 2.757 1 0
Separation of Sister Chromatids R-HSA-2467813 1.821454e-03 2.740 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.885205e-03 2.725 0 0
Neurodegenerative Diseases R-HSA-8863678 1.860649e-03 2.730 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.860649e-03 2.730 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.957413e-03 2.708 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.046896e-03 2.689 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.162819e-03 2.665 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.162819e-03 2.665 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.101869e-03 2.677 0 0
RMTs methylate histone arginines R-HSA-3214858 2.101869e-03 2.677 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.220720e-03 2.654 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.302941e-03 2.638 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.302941e-03 2.638 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.315551e-03 2.635 0 0
DNA methylation R-HSA-5334118 2.328687e-03 2.633 0 0
Cellular responses to stress R-HSA-2262752 2.514930e-03 2.599 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.767464e-03 2.558 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.822735e-03 2.549 0 0
MAP2K and MAPK activation R-HSA-5674135 2.822735e-03 2.549 0 0
HDACs deacetylate histones R-HSA-3214815 2.891581e-03 2.539 0 0
Interleukin-37 signaling R-HSA-9008059 2.948704e-03 2.530 0 0
Meiotic recombination R-HSA-912446 3.260534e-03 2.487 0 0
Mitotic Prophase R-HSA-68875 3.144703e-03 2.502 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.348035e-03 2.475 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.400690e-03 2.468 0 0
Signaling by ALK in cancer R-HSA-9700206 3.400690e-03 2.468 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.414711e-03 2.467 0 0
Signaling by Interleukins R-HSA-449147 3.537915e-03 2.451 0 0
Opioid Signalling R-HSA-111885 3.910794e-03 2.408 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.960691e-03 2.402 0 0
HATs acetylate histones R-HSA-3214847 3.996695e-03 2.398 0 0
G-protein mediated events R-HSA-112040 4.190956e-03 2.378 0 0
Deubiquitination R-HSA-5688426 4.114871e-03 2.386 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.309997e-03 2.366 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.343994e-03 2.362 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.558944e-03 2.341 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.973507e-03 2.303 0 0
RET signaling R-HSA-8853659 5.114582e-03 2.291 0 0
Calmodulin induced events R-HSA-111933 5.114582e-03 2.291 0 0
CaM pathway R-HSA-111997 5.114582e-03 2.291 0 0
Cell-Cell communication R-HSA-1500931 5.130405e-03 2.290 0 0
Potassium Channels R-HSA-1296071 5.177683e-03 2.286 0 0
Selective autophagy R-HSA-9663891 5.391177e-03 2.268 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.572784e-03 2.254 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.588049e-03 2.253 0 0
Integrin signaling R-HSA-354192 5.654353e-03 2.248 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.654353e-03 2.248 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.312514e-03 2.200 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.355437e-03 2.197 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.402047e-03 2.194 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.831098e-03 2.166 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.831098e-03 2.166 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.924303e-03 2.160 1 0
Interleukin-12 signaling R-HSA-9020591 7.251842e-03 2.140 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.325061e-03 2.135 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 7.347066e-03 2.134 0 0
RNA Polymerase II Transcription R-HSA-73857 7.475650e-03 2.126 1 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.086156e-03 2.092 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 7.912799e-03 2.102 0 0
Ca-dependent events R-HSA-111996 7.858377e-03 2.105 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.362433e-03 2.078 0 0
Nuclear Envelope Breakdown R-HSA-2980766 8.431880e-03 2.074 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.900326e-03 2.051 0 0
Defective pyroptosis R-HSA-9710421 9.283030e-03 2.032 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 9.534589e-03 2.021 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.001917e-02 1.999 0 0
Packaging Of Telomere Ends R-HSA-171306 1.036086e-02 1.985 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.056386e-02 1.976 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.056386e-02 1.976 0 0
Oncogene Induced Senescence R-HSA-2559585 1.005306e-02 1.998 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.036086e-02 1.985 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.623753e-03 2.017 0 0
Reproduction R-HSA-1474165 1.047267e-02 1.980 0 0
Sensory processing of sound R-HSA-9659379 1.052559e-02 1.978 0 0
Netrin-1 signaling R-HSA-373752 1.090456e-02 1.962 1 1
Regulation of TP53 Degradation R-HSA-6804757 1.199889e-02 1.921 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.214857e-02 1.915 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.214857e-02 1.915 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.214857e-02 1.915 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.214857e-02 1.915 0 0
DAG and IP3 signaling R-HSA-1489509 1.274044e-02 1.895 0 0
Signaling by ROBO receptors R-HSA-376176 1.285609e-02 1.891 0 0
Cell junction organization R-HSA-446728 1.293866e-02 1.888 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.480847e-02 1.829 0 0
Signaling by EGFR R-HSA-177929 1.477005e-02 1.831 0 0
DARPP-32 events R-HSA-180024 1.534631e-02 1.814 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.429354e-02 1.845 0 0
Gene expression (Transcription) R-HSA-74160 1.516219e-02 1.819 1 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.429354e-02 1.845 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.408482e-02 1.851 0 0
Developmental Biology R-HSA-1266738 1.433356e-02 1.844 1 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.581849e-02 1.801 0 0
Membrane Trafficking R-HSA-199991 1.632954e-02 1.787 0 0
Muscle contraction R-HSA-397014 1.713284e-02 1.766 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.721518e-02 1.764 0 0
Long-term potentiation R-HSA-9620244 1.723673e-02 1.764 0 0
Generic Transcription Pathway R-HSA-212436 1.785488e-02 1.748 1 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.918637e-02 1.717 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.921621e-02 1.716 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.960518e-02 1.708 0 0
GPER1 signaling R-HSA-9634597 1.971289e-02 1.705 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.011648e-02 1.696 0 0
TRP channels R-HSA-3295583 2.088083e-02 1.680 0 0
Ephrin signaling R-HSA-3928664 2.118045e-02 1.674 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.135813e-02 1.670 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.366514e-02 1.626 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.366514e-02 1.626 0 0
Activation of RAC1 R-HSA-428540 2.402575e-02 1.619 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.402575e-02 1.619 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.402575e-02 1.619 0 0
Trafficking of AMPA receptors R-HSA-399719 2.194736e-02 1.659 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.174424e-02 1.663 0 0
Adrenoceptors R-HSA-390696 2.366514e-02 1.626 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.260116e-02 1.646 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.389697e-02 1.622 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.366514e-02 1.626 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.299557e-02 1.638 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.299557e-02 1.638 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.412929e-02 1.617 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.455281e-02 1.610 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.492173e-02 1.603 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.505593e-02 1.601 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.575181e-02 1.589 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.584869e-02 1.588 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.593522e-02 1.586 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.617151e-02 1.582 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.633255e-02 1.580 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.638690e-02 1.579 0 0
FLT3 Signaling R-HSA-9607240 2.638690e-02 1.579 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.655361e-02 1.576 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.657174e-02 1.576 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.908632e-02 1.536 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.042236e-02 1.517 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.042236e-02 1.517 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.042236e-02 1.517 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.042236e-02 1.517 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.035981e-02 1.518 0 0
DNA Double Strand Break Response R-HSA-5693606 2.984378e-02 1.525 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.042236e-02 1.517 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.908632e-02 1.536 0 0
PLC beta mediated events R-HSA-112043 2.762654e-02 1.559 0 0
Cardiac conduction R-HSA-5576891 2.914019e-02 1.536 0 0
Transmission across Chemical Synapses R-HSA-112315 2.943911e-02 1.531 0 0
Ub-specific processing proteases R-HSA-5689880 2.672638e-02 1.573 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.848696e-02 1.545 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.672638e-02 1.573 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.672638e-02 1.573 0 0
Interleukin-12 family signaling R-HSA-447115 2.784726e-02 1.555 0 0
Voltage gated Potassium channels R-HSA-1296072 3.056587e-02 1.515 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.069349e-02 1.513 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.069349e-02 1.513 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.097899e-02 1.509 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.143321e-02 1.503 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.143321e-02 1.503 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.143321e-02 1.503 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.143321e-02 1.503 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.143321e-02 1.503 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.215886e-02 1.493 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.229682e-02 1.491 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.229682e-02 1.491 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.229682e-02 1.491 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.229682e-02 1.491 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.253849e-02 1.488 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.257461e-02 1.487 0 0
Neurexins and neuroligins R-HSA-6794361 3.309277e-02 1.480 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.494805e-02 1.457 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.494805e-02 1.457 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.494805e-02 1.457 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.494805e-02 1.457 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.494805e-02 1.457 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.494805e-02 1.457 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.494805e-02 1.457 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.754776e-02 1.425 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 4.018839e-02 1.396 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.543731e-02 1.451 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.044474e-02 1.393 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.543731e-02 1.451 1 1
DNA Repair R-HSA-73894 3.962898e-02 1.402 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.756808e-02 1.425 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.044474e-02 1.393 0 0
Signaling by ALK R-HSA-201556 4.044474e-02 1.393 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.474941e-02 1.459 0 0
Depyrimidination R-HSA-73928 3.474941e-02 1.459 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.062100e-02 1.391 0 0
RAF activation R-HSA-5673000 4.100631e-02 1.387 0 0
Signal amplification R-HSA-392518 4.100631e-02 1.387 0 0
Mitophagy R-HSA-5205647 4.100631e-02 1.387 0 0
Activation of BH3-only proteins R-HSA-114452 4.112126e-02 1.386 0 0
G2/M Transition R-HSA-69275 4.210003e-02 1.376 0 0
Signaling by NOTCH1 R-HSA-1980143 4.298179e-02 1.367 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.332668e-02 1.363 0 0
Regulation of CDH11 function R-HSA-9762292 4.332668e-02 1.363 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.400363e-02 1.357 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.480404e-02 1.349 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.480404e-02 1.349 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.480404e-02 1.349 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.480404e-02 1.349 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.480404e-02 1.349 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.496757e-02 1.347 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.496757e-02 1.347 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.537138e-02 1.343 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.034816e-02 1.298 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.684620e-02 1.329 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.684620e-02 1.329 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.613974e-02 1.336 0 0
Nucleosome assembly R-HSA-774815 5.061041e-02 1.296 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.061041e-02 1.296 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.743096e-02 1.324 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.465271e-02 1.262 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.070345e-02 1.295 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.142306e-02 1.289 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.634190e-02 1.334 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.359875e-02 1.271 0 0
Homology Directed Repair R-HSA-5693538 5.307711e-02 1.275 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.397171e-02 1.268 0 0
Polo-like kinase mediated events R-HSA-156711 5.397171e-02 1.268 0 0
G0 and Early G1 R-HSA-1538133 5.508065e-02 1.259 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.106741e-02 1.292 0 0
Signaling by WNT in cancer R-HSA-4791275 5.508065e-02 1.259 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.508065e-02 1.259 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.715295e-02 1.326 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.796334e-02 1.319 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.236385e-02 1.281 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.449385e-02 1.264 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.397171e-02 1.268 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.142306e-02 1.289 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.781737e-02 1.320 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.230728e-02 1.281 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.775727e-02 1.321 0 0
Notch-HLH transcription pathway R-HSA-350054 5.550380e-02 1.256 0 0
Signaling by APC mutants R-HSA-4839744 5.597426e-02 1.252 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.597426e-02 1.252 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.597426e-02 1.252 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.597426e-02 1.252 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.785590e-02 1.238 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.845234e-02 1.233 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.845234e-02 1.233 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.845234e-02 1.233 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.006566e-02 1.221 0 0
MECP2 regulates transcription factors R-HSA-9022707 6.006566e-02 1.221 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.070676e-02 1.217 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.076601e-02 1.216 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.076601e-02 1.216 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 6.125825e-02 1.213 0 0
Cleavage of the damaged purine R-HSA-110331 6.125825e-02 1.213 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 6.167273e-02 1.210 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 6.167273e-02 1.210 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 6.167273e-02 1.210 0 0
p75NTR signals via NF-kB R-HSA-193639 6.194689e-02 1.208 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.194689e-02 1.208 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 6.194689e-02 1.208 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.194689e-02 1.208 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.194689e-02 1.208 0 0
Glycolysis R-HSA-70171 6.237821e-02 1.205 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.310440e-02 1.200 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.310440e-02 1.200 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.448674e-02 1.191 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.448674e-02 1.191 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 6.511717e-02 1.186 0 0
Centrosome maturation R-HSA-380287 6.544505e-02 1.184 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.544505e-02 1.184 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.618927e-02 1.179 0 0
Depurination R-HSA-73927 6.924801e-02 1.160 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 7.158385e-02 1.145 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 7.158385e-02 1.145 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 7.158385e-02 1.145 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 8.369669e-02 1.077 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 8.369669e-02 1.077 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 8.369669e-02 1.077 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.881774e-02 1.103 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.881774e-02 1.103 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.881774e-02 1.103 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 7.052828e-02 1.152 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.696019e-02 1.061 0 0
Phase 4 - resting membrane potential R-HSA-5576886 7.499625e-02 1.125 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.625629e-02 1.118 0 0
HDMs demethylate histones R-HSA-3214842 8.725723e-02 1.059 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.725723e-02 1.059 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.408377e-02 1.130 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 8.451447e-02 1.073 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.131023e-02 1.090 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.131023e-02 1.090 0 0
G alpha (z) signalling events R-HSA-418597 8.214623e-02 1.085 1 1
Developmental Lineages of the Mammary Gland R-HSA-9924644 8.240045e-02 1.084 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.184455e-02 1.144 0 0
Peptide chain elongation R-HSA-156902 8.061214e-02 1.094 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 7.860920e-02 1.105 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 8.369669e-02 1.077 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.696019e-02 1.061 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.499625e-02 1.125 0 0
Nuclear import of Rev protein R-HSA-180746 8.131023e-02 1.090 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 8.369669e-02 1.077 0 0
Metabolism of RNA R-HSA-8953854 7.294501e-02 1.137 0 0
Cell-cell junction organization R-HSA-421270 7.615732e-02 1.118 0 0
Signaling by AXIN mutants R-HSA-4839735 7.052828e-02 1.152 0 0
Signaling by AMER1 mutants R-HSA-4839748 7.052828e-02 1.152 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.715187e-02 1.060 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.881774e-02 1.103 0 0
NrCAM interactions R-HSA-447038 8.369669e-02 1.077 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.787008e-02 1.056 0 0
Hemostasis R-HSA-109582 8.830755e-02 1.054 1 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.914593e-02 1.050 0 0
Macroautophagy R-HSA-1632852 9.007287e-02 1.045 0 0
Ion homeostasis R-HSA-5578775 9.024676e-02 1.045 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.150550e-02 1.039 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.188493e-02 1.037 0 0
Adherens junctions interactions R-HSA-418990 9.204666e-02 1.036 0 0
Protein-protein interactions at synapses R-HSA-6794362 9.250863e-02 1.034 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 9.357539e-02 1.029 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.159947e-01 0.936 0 0
Regulation of TP53 Expression R-HSA-6804754 1.159947e-01 0.936 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.159947e-01 0.936 0 0
Diseases of cellular response to stress R-HSA-9675132 1.159947e-01 0.936 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.159947e-01 0.936 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.159947e-01 0.936 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.159947e-01 0.936 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.159947e-01 0.936 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.159947e-01 0.936 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.159947e-01 0.936 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.159947e-01 0.936 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.159947e-01 0.936 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.159947e-01 0.936 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.159947e-01 0.936 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.159947e-01 0.936 0 0
Potassium transport channels R-HSA-1296067 1.159947e-01 0.936 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.127587e-01 0.948 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.127587e-01 0.948 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.127587e-01 0.948 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.127587e-01 0.948 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.001196e-01 0.999 0 0
WNT mediated activation of DVL R-HSA-201688 1.001196e-01 0.999 0 0
Gap junction degradation R-HSA-190873 1.001196e-01 0.999 0 0
ALK mutants bind TKIs R-HSA-9700645 1.001196e-01 0.999 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.237737e-01 0.907 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.237737e-01 0.907 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.237737e-01 0.907 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.052057e-01 0.978 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.052057e-01 0.978 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.052057e-01 0.978 0 0
Regulation of KIT signaling R-HSA-1433559 1.251690e-01 0.903 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.251690e-01 0.903 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.251690e-01 0.903 0 0
cGMP effects R-HSA-418457 1.251690e-01 0.903 0 0
PKA activation in glucagon signalling R-HSA-164378 1.226399e-01 0.911 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.183476e-01 0.927 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 9.577943e-02 1.019 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 9.577943e-02 1.019 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.132639e-01 0.946 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.207807e-01 0.918 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.707440e-02 1.013 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.140753e-01 0.943 0 0
Translation initiation complex formation R-HSA-72649 1.253426e-01 0.902 0 0
Metabolism of non-coding RNA R-HSA-194441 1.174452e-01 0.930 0 0
snRNP Assembly R-HSA-191859 1.174452e-01 0.930 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.005328e-01 0.998 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.264628e-01 0.898 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.016635e-01 0.993 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.082815e-01 0.965 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.264325e-01 0.898 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.065271e-01 0.973 0 0
Chromosome Maintenance R-HSA-73886 9.604560e-02 1.018 0 0
Telomere Maintenance R-HSA-157579 1.156698e-01 0.937 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.113160e-01 0.953 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.978325e-02 1.001 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.154987e-01 0.937 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.208203e-01 0.918 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.493393e-02 1.023 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.001196e-01 0.999 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.207807e-01 0.918 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.076429e-01 0.968 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 1.127587e-01 0.948 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.127587e-01 0.948 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.264325e-01 0.898 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.849569e-02 1.007 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.207807e-01 0.918 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.140753e-01 0.943 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.001196e-01 0.999 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.001196e-01 0.999 0 0
PKA activation R-HSA-163615 1.226399e-01 0.911 0 0
mTORC1-mediated signalling R-HSA-166208 1.183476e-01 0.927 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.232345e-01 0.909 0 0
G2/M Checkpoints R-HSA-69481 1.018699e-01 0.992 0 0
Autophagy R-HSA-9612973 1.109094e-01 0.955 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.021412e-01 0.991 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.021412e-01 0.991 0 0
Calcineurin activates NFAT R-HSA-2025928 1.001196e-01 0.999 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.052057e-01 0.978 0 0
MTOR signalling R-HSA-165159 1.188517e-01 0.925 0 0
Signaling by TGFBR3 R-HSA-9839373 1.015211e-01 0.993 0 0
Co-stimulation by CD28 R-HSA-389356 1.225283e-01 0.912 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.052057e-01 0.978 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.237737e-01 0.907 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.237737e-01 0.907 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.031856e-01 0.986 0 0
Stimuli-sensing channels R-HSA-2672351 1.156937e-01 0.937 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.052057e-01 0.978 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.031856e-01 0.986 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.031856e-01 0.986 0 0
Interleukin-1 family signaling R-HSA-446652 1.237812e-01 0.907 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.188517e-01 0.925 0 0
Platelet sensitization by LDL R-HSA-432142 1.226399e-01 0.911 0 0
Diseases of DNA repair R-HSA-9675135 1.015211e-01 0.993 0 0
Maturation of nucleoprotein R-HSA-9683610 1.052057e-01 0.978 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.264325e-01 0.898 0 0
Signaling by Leptin R-HSA-2586552 1.237737e-01 0.907 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.253426e-01 0.902 0 0
Gene Silencing by RNA R-HSA-211000 1.086920e-01 0.964 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.274708e-01 0.895 0 0
RAB geranylgeranylation R-HSA-8873719 1.274708e-01 0.895 0 0
Striated Muscle Contraction R-HSA-390522 1.344848e-01 0.871 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.344848e-01 0.871 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.344848e-01 0.871 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.344848e-01 0.871 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.345923e-01 0.871 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.354147e-01 0.868 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.354147e-01 0.868 0 0
KIT mutants bind TKIs R-HSA-9669921 1.354147e-01 0.868 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.354147e-01 0.868 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.354147e-01 0.868 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.354147e-01 0.868 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.354147e-01 0.868 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.354147e-01 0.868 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.354147e-01 0.868 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.354147e-01 0.868 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.354147e-01 0.868 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.354147e-01 0.868 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.354147e-01 0.868 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.354147e-01 0.868 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.354147e-01 0.868 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.354147e-01 0.868 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.354147e-01 0.868 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.354147e-01 0.868 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.354147e-01 0.868 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.354147e-01 0.868 0 0
Signaling by NTRKs R-HSA-166520 1.380024e-01 0.860 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.388188e-01 0.858 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.411854e-01 0.850 0 0
The NLRP3 inflammasome R-HSA-844456 1.411854e-01 0.850 0 0
Signaling by WNT R-HSA-195721 1.420560e-01 0.848 0 0
CREB phosphorylation R-HSA-199920 1.450379e-01 0.839 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 1.450379e-01 0.839 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.654050e-01 0.781 0 0
MET interacts with TNS proteins R-HSA-8875513 1.654050e-01 0.781 0 0
Axonal growth stimulation R-HSA-209563 1.654050e-01 0.781 0 0
Classical Kir channels R-HSA-1296053 1.654050e-01 0.781 0 0
HCN channels R-HSA-1296061 2.176475e-01 0.662 0 0
NADE modulates death signalling R-HSA-205025 2.176475e-01 0.662 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.176475e-01 0.662 0 0
ATP sensitive Potassium channels R-HSA-1296025 2.176475e-01 0.662 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.176475e-01 0.662 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.176475e-01 0.662 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.176475e-01 0.662 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.176475e-01 0.662 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.799051e-01 0.745 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.799051e-01 0.745 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.799051e-01 0.745 0 0
Netrin mediated repulsion signals R-HSA-418886 1.799051e-01 0.745 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.799051e-01 0.745 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.799051e-01 0.745 0 0
Disinhibition of SNARE formation R-HSA-114516 1.799051e-01 0.745 0 0
Type I hemidesmosome assembly R-HSA-446107 2.167378e-01 0.664 0 0
Regulation by c-FLIP R-HSA-3371378 2.167378e-01 0.664 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 2.167378e-01 0.664 0 0
Dimerization of procaspase-8 R-HSA-69416 2.167378e-01 0.664 0 0
FGFR1b ligand binding and activation R-HSA-190370 2.167378e-01 0.664 0 0
Formation of annular gap junctions R-HSA-196025 2.167378e-01 0.664 0 0
NF-kB is activated and signals survival R-HSA-209560 1.771454e-01 0.752 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.771454e-01 0.752 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.771454e-01 0.752 0 0
DCC mediated attractive signaling R-HSA-418885 1.467282e-01 0.833 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.467282e-01 0.833 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.697400e-01 0.770 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.063037e-01 0.685 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.063037e-01 0.685 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.609369e-01 0.793 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.609369e-01 0.793 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.518686e-01 0.819 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.518686e-01 0.819 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 1.817981e-01 0.740 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.701158e-01 0.769 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.701158e-01 0.769 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.591610e-01 0.798 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.591610e-01 0.798 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.036623e-01 0.691 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.489594e-01 0.827 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.761479e-01 0.754 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.476689e-01 0.831 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.606579e-01 0.794 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.999995e-01 0.699 0 0
HCMV Early Events R-HSA-9609690 1.727099e-01 0.763 0 0
Co-inhibition by PD-1 R-HSA-389948 2.014449e-01 0.696 0 0
EGFR downregulation R-HSA-182971 1.761479e-01 0.754 0 0
Formation of definitive endoderm R-HSA-9823730 1.609369e-01 0.793 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.940447e-01 0.712 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.092370e-01 0.679 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.892641e-01 0.723 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.603020e-01 0.795 0 0
TGFBR3 expression R-HSA-9839394 1.701158e-01 0.769 0 0
Activation of GABAB receptors R-HSA-991365 1.981602e-01 0.703 0 0
Signaling by ERBB2 R-HSA-1227986 1.980964e-01 0.703 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.641731e-01 0.785 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.130815e-01 0.671 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.719622e-01 0.765 0 0
MHC class II antigen presentation R-HSA-2132295 1.521411e-01 0.818 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.176475e-01 0.662 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.799051e-01 0.745 0 0
Eukaryotic Translation Termination R-HSA-72764 1.489533e-01 0.827 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.613525e-01 0.792 0 0
Myogenesis R-HSA-525793 1.892641e-01 0.723 0 0
RNA Polymerase I Transcription R-HSA-73864 1.944898e-01 0.711 0 0
Killing mechanisms R-HSA-9664420 1.697400e-01 0.770 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 1.697400e-01 0.770 0 0
GABA B receptor activation R-HSA-977444 1.981602e-01 0.703 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.501434e-01 0.823 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.063037e-01 0.685 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.063037e-01 0.685 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.940447e-01 0.712 0 0
GABA receptor activation R-HSA-977443 1.980964e-01 0.703 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.715457e-01 0.766 0 0
Interleukin-2 signaling R-HSA-9020558 1.495393e-01 0.825 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.495387e-01 0.825 0 0
Adaptive Immune System R-HSA-1280218 1.963374e-01 0.707 1 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.654050e-01 0.781 0 0
Protein methylation R-HSA-8876725 1.467282e-01 0.833 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.701158e-01 0.769 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.591610e-01 0.798 0 0
Aggrephagy R-HSA-9646399 1.532105e-01 0.815 0 0
Cardiogenesis R-HSA-9733709 2.123484e-01 0.673 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.675814e-01 0.776 0 0
NGF-stimulated transcription R-HSA-9031628 1.987443e-01 0.702 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.987443e-01 0.702 0 0
Cellular response to heat stress R-HSA-3371556 1.883684e-01 0.725 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.641731e-01 0.785 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.704407e-01 0.768 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.467282e-01 0.833 0 0
Signaling by LTK R-HSA-9842663 2.063037e-01 0.685 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.704407e-01 0.768 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.840273e-01 0.735 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.976820e-01 0.704 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.976820e-01 0.704 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.123484e-01 0.673 0 0
PECAM1 interactions R-HSA-210990 1.495393e-01 0.825 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.771454e-01 0.752 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.773410e-01 0.751 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.773410e-01 0.751 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.773410e-01 0.751 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.571820e-01 0.804 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 1.799051e-01 0.745 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.167378e-01 0.664 0 0
Disorders of Developmental Biology R-HSA-9675151 1.940447e-01 0.712 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.532105e-01 0.815 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.893034e-01 0.723 0 0
Gap junction trafficking and regulation R-HSA-157858 2.139589e-01 0.670 0 0
Base Excision Repair R-HSA-73884 2.022360e-01 0.694 0 0
PI Metabolism R-HSA-1483255 1.570960e-01 0.804 0 0
TBC/RABGAPs R-HSA-8854214 2.142903e-01 0.669 0 0
Formation of the nephric duct R-HSA-9830364 1.701158e-01 0.769 0 0
OAS antiviral response R-HSA-8983711 2.063037e-01 0.685 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.063037e-01 0.685 0 0
Pervasive developmental disorders R-HSA-9005895 2.063037e-01 0.685 0 0
Disorders of Nervous System Development R-HSA-9697154 2.063037e-01 0.685 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.092370e-01 0.679 0 0
UCH proteinases R-HSA-5689603 1.715457e-01 0.766 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.520048e-01 0.818 0 0
Sodium/Proton exchangers R-HSA-425986 2.167378e-01 0.664 0 0
Glucose metabolism R-HSA-70326 2.101591e-01 0.677 0 0
PKR-mediated signaling R-HSA-9833482 2.188104e-01 0.660 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.188104e-01 0.660 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.194715e-01 0.659 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.194715e-01 0.659 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.194715e-01 0.659 0 0
G alpha (s) signalling events R-HSA-418555 2.260102e-01 0.646 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.264151e-01 0.645 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.264151e-01 0.645 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.299516e-01 0.638 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.299516e-01 0.638 0 0
Pyroptosis R-HSA-5620971 2.299516e-01 0.638 0 0
Cyclin D associated events in G1 R-HSA-69231 2.309306e-01 0.637 0 0
G1 Phase R-HSA-69236 2.309306e-01 0.637 0 0
Gap junction trafficking R-HSA-190828 2.309306e-01 0.637 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.314411e-01 0.636 0 0
Amyloid fiber formation R-HSA-977225 2.314496e-01 0.636 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.316223e-01 0.635 0 0
Formation of axial mesoderm R-HSA-9796292 2.367183e-01 0.626 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.367183e-01 0.626 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.367183e-01 0.626 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.411768e-01 0.618 0 0
Adipogenesis R-HSA-9843745 2.433980e-01 0.614 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.458427e-01 0.609 0 0
GAB1 signalosome R-HSA-180292 2.458427e-01 0.609 0 0
Apoptotic factor-mediated response R-HSA-111471 2.458427e-01 0.609 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.458427e-01 0.609 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.458427e-01 0.609 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.458427e-01 0.609 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.465722e-01 0.608 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.480387e-01 0.605 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.490375e-01 0.604 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.490375e-01 0.604 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.498976e-01 0.602 0 0
Diseases of Immune System R-HSA-5260271 2.498976e-01 0.602 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.499362e-01 0.602 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.511082e-01 0.600 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.513207e-01 0.600 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.513207e-01 0.600 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.513207e-01 0.600 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.524991e-01 0.598 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.524991e-01 0.598 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.524991e-01 0.598 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.524991e-01 0.598 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.524991e-01 0.598 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.524991e-01 0.598 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.524991e-01 0.598 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.524991e-01 0.598 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.524991e-01 0.598 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.524991e-01 0.598 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.524991e-01 0.598 0 0
Inhibition of PKR R-HSA-169131 2.524991e-01 0.598 0 0
GPCR downstream signalling R-HSA-388396 2.548563e-01 0.594 1 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.549437e-01 0.594 0 0
Lipophagy R-HSA-9613354 2.549437e-01 0.594 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.549437e-01 0.594 0 0
CASP8 activity is inhibited R-HSA-5218900 2.549437e-01 0.594 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.549437e-01 0.594 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.549437e-01 0.594 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.549437e-01 0.594 0 0
Interleukin-1 processing R-HSA-448706 2.549437e-01 0.594 0 0
IGF1R signaling cascade R-HSA-2428924 2.552170e-01 0.593 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.537334e-01 0.451 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.537334e-01 0.451 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.537334e-01 0.451 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.537334e-01 0.451 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.537334e-01 0.451 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.537334e-01 0.451 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.537334e-01 0.451 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.537334e-01 0.451 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.537334e-01 0.451 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.537334e-01 0.451 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.537334e-01 0.451 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.537334e-01 0.451 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.537334e-01 0.451 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.537334e-01 0.451 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.537334e-01 0.451 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.537334e-01 0.451 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.537334e-01 0.451 0 0
MPS IIID - Sanfilippo syndrome D R-HSA-2206305 3.537334e-01 0.451 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.537334e-01 0.451 0 0
Intestinal infectious diseases R-HSA-8942233 3.537334e-01 0.451 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.537334e-01 0.451 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.537334e-01 0.451 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.537334e-01 0.451 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.537334e-01 0.451 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.537334e-01 0.451 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.710501e-01 0.567 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.710501e-01 0.567 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.710501e-01 0.567 0 0
IRS activation R-HSA-74713 2.710501e-01 0.567 0 0
G2 Phase R-HSA-68911 2.710501e-01 0.567 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.710501e-01 0.567 0 0
TRAIL signaling R-HSA-75158 3.243413e-01 0.489 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.243413e-01 0.489 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.243413e-01 0.489 0 0
Phosphorylation of Emi1 R-HSA-176417 3.243413e-01 0.489 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.243413e-01 0.489 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 4.412626e-01 0.355 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.412626e-01 0.355 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.412626e-01 0.355 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.412626e-01 0.355 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.412626e-01 0.355 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.412626e-01 0.355 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.412626e-01 0.355 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.939765e-01 0.532 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.939765e-01 0.532 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.765722e-01 0.424 0 0
STAT5 Activation R-HSA-9645135 3.765722e-01 0.424 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.765722e-01 0.424 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.765722e-01 0.424 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.765722e-01 0.424 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.333448e-01 0.477 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.333448e-01 0.477 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.001477e-01 0.523 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.001477e-01 0.523 0 0
Deadenylation of mRNA R-HSA-429947 2.741021e-01 0.562 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.741021e-01 0.562 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.006967e-01 0.522 0 0
Phosphorylation of the APC/C R-HSA-176412 3.326048e-01 0.478 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.726163e-01 0.429 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.726163e-01 0.429 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.270529e-01 0.370 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 4.270529e-01 0.370 0 0
CHL1 interactions R-HSA-447041 4.270529e-01 0.370 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.270529e-01 0.370 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.270529e-01 0.370 0 0
IFNG signaling activates MAPKs R-HSA-9732724 4.270529e-01 0.370 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.270529e-01 0.370 0 0
SOS-mediated signalling R-HSA-112412 4.270529e-01 0.370 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.169413e-01 0.287 0 0
Invadopodia formation R-HSA-8941237 5.169413e-01 0.287 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.169413e-01 0.287 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.169413e-01 0.287 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 5.169413e-01 0.287 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.169413e-01 0.287 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.169413e-01 0.287 0 0
MET activates PTPN11 R-HSA-8865999 5.169413e-01 0.287 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.652123e-01 0.437 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.652123e-01 0.437 0 0
Downstream signal transduction R-HSA-186763 2.956593e-01 0.529 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.238696e-01 0.490 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.114190e-01 0.386 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.114190e-01 0.386 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.184436e-01 0.497 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.834796e-01 0.547 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.977376e-01 0.400 0 0
RSK activation R-HSA-444257 4.752998e-01 0.323 0 0
Activation of RAS in B cells R-HSA-1169092 4.752998e-01 0.323 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.072552e-01 0.513 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.415144e-01 0.467 0 0
Telomere Extension By Telomerase R-HSA-171319 3.747356e-01 0.426 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.494396e-01 0.347 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.299702e-01 0.367 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.299702e-01 0.367 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.881543e-01 0.411 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.891992e-01 0.539 0 0
Viral mRNA Translation R-HSA-192823 3.075680e-01 0.512 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.421653e-01 0.354 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.421653e-01 0.354 0 0
G1/S-Specific Transcription R-HSA-69205 4.348839e-01 0.362 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 4.928352e-01 0.307 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.973547e-01 0.303 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.583334e-01 0.339 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.624289e-01 0.335 0 0
Neutrophil degranulation R-HSA-6798695 4.947719e-01 0.306 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.258931e-01 0.487 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.002882e-01 0.398 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.257754e-01 0.371 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.261698e-01 0.370 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 2.877713e-01 0.541 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.821896e-01 0.418 0 0
Specification of the neural plate border R-HSA-9834899 2.729777e-01 0.564 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.415144e-01 0.467 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.624289e-01 0.335 0 0
Signaling by FGFR3 R-HSA-5654741 3.671929e-01 0.435 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.299702e-01 0.367 0 0
Signaling by FGFR4 R-HSA-5654743 3.270259e-01 0.485 0 0
Signaling by SCF-KIT R-HSA-1433557 4.637911e-01 0.334 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.494396e-01 0.347 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.299702e-01 0.367 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.726163e-01 0.429 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.005593e-01 0.522 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.987880e-01 0.525 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.014983e-01 0.521 0 0
Signaling by FGFR1 R-HSA-5654736 4.537152e-01 0.343 0 0
Signal attenuation R-HSA-74749 2.939765e-01 0.532 0 0
Inwardly rectifying K+ channels R-HSA-1296065 3.184436e-01 0.497 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.617237e-01 0.336 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.864200e-01 0.313 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.928352e-01 0.307 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.347544e-01 0.362 0 0
Frs2-mediated activation R-HSA-170968 4.494396e-01 0.347 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.942994e-01 0.306 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.537152e-01 0.343 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.703629e-01 0.568 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.726163e-01 0.429 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.752998e-01 0.323 0 0
PI3K Cascade R-HSA-109704 4.686084e-01 0.329 0 0
Interleukin-15 signaling R-HSA-8983432 4.114190e-01 0.386 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.411997e-01 0.467 0 0
Integration of energy metabolism R-HSA-163685 3.073079e-01 0.512 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.243413e-01 0.489 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 3.001477e-01 0.523 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.270529e-01 0.370 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.973547e-01 0.303 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.968716e-01 0.304 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.342764e-01 0.476 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.333448e-01 0.477 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.617237e-01 0.336 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.761575e-01 0.322 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.484280e-01 0.348 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.484280e-01 0.348 0 0
Interleukin-2 family signaling R-HSA-451927 3.772080e-01 0.423 0 0
NADPH regeneration R-HSA-389542 3.765722e-01 0.424 0 0
Sodium/Calcium exchangers R-HSA-425561 3.726163e-01 0.429 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.140055e-01 0.383 0 0
HSF1-dependent transactivation R-HSA-3371571 3.579327e-01 0.446 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.015637e-01 0.521 0 0
Hedgehog 'off' state R-HSA-5610787 4.490269e-01 0.348 0 0
Interferon gamma signaling R-HSA-877300 5.071157e-01 0.295 0 0
Regulation of insulin secretion R-HSA-422356 4.200617e-01 0.377 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.973547e-01 0.303 0 0
Repression of WNT target genes R-HSA-4641265 4.114190e-01 0.386 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 4.002882e-01 0.398 0 0
Cellular response to chemical stress R-HSA-9711123 2.817460e-01 0.550 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 3.326048e-01 0.478 0 0
Interferon Signaling R-HSA-913531 3.061110e-01 0.514 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.847930e-01 0.545 0 0
Signalling to ERKs R-HSA-187687 4.115492e-01 0.386 0 0
GPVI-mediated activation cascade R-HSA-114604 2.918871e-01 0.535 0 0
DNA Damage Bypass R-HSA-73893 3.202401e-01 0.495 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.243413e-01 0.489 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.939765e-01 0.532 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.680949e-01 0.572 0 0
Activation of SMO R-HSA-5635838 3.326048e-01 0.478 0 0
Tight junction interactions R-HSA-420029 2.987880e-01 0.525 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 3.977376e-01 0.400 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.752998e-01 0.323 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.752998e-01 0.323 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.752998e-01 0.323 0 0
FGFR1c ligand binding and activation R-HSA-190373 4.494396e-01 0.347 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 5.048982e-01 0.297 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.652123e-01 0.437 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.652123e-01 0.437 0 0
Acyl chain remodelling of PS R-HSA-1482801 2.987880e-01 0.525 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.002882e-01 0.398 0 0
Platelet calcium homeostasis R-HSA-418360 4.002882e-01 0.398 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.411997e-01 0.467 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.828427e-01 0.417 0 0
Regulation of CDH1 Function R-HSA-9764561 4.727705e-01 0.325 0 0
Signaling by Hedgehog R-HSA-5358351 4.076447e-01 0.390 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.987298e-01 0.525 0 0
Parasitic Infection Pathways R-HSA-9824443 2.803908e-01 0.552 0 0
Leishmania infection R-HSA-9658195 2.803908e-01 0.552 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 3.726163e-01 0.429 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.752998e-01 0.323 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.864200e-01 0.313 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.008735e-01 0.300 0 0
Vesicle-mediated transport R-HSA-5653656 4.617080e-01 0.336 0 0
rRNA processing R-HSA-72312 5.002809e-01 0.301 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.687684e-01 0.571 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.710501e-01 0.567 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.686328e-01 0.571 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.128555e-01 0.505 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.140900e-01 0.503 0 0
Signal transduction by L1 R-HSA-445144 4.928352e-01 0.307 0 0
Immune System R-HSA-168256 3.470479e-01 0.460 1 0
Rab regulation of trafficking R-HSA-9007101 2.786394e-01 0.555 0 0
Cilium Assembly R-HSA-5617833 4.100475e-01 0.387 0 0
Interleukin-7 signaling R-HSA-1266695 2.987880e-01 0.525 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.571900e-01 0.447 0 0
Interleukin-9 signaling R-HSA-8985947 4.752998e-01 0.323 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.553766e-01 0.342 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.650117e-01 0.577 0 0
Signaling by PTK6 R-HSA-8848021 3.411997e-01 0.467 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.411997e-01 0.467 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.537334e-01 0.451 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.412626e-01 0.355 0 0
C6 deamination of adenosine R-HSA-75102 4.412626e-01 0.355 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.412626e-01 0.355 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.412626e-01 0.355 0 0
MAPK3 (ERK1) activation R-HSA-110056 2.939765e-01 0.532 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.765722e-01 0.424 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.333448e-01 0.477 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.001477e-01 0.523 0 0
Protein hydroxylation R-HSA-9629569 3.006967e-01 0.522 0 0
Negative regulation of FLT3 R-HSA-9706369 3.326048e-01 0.478 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.270529e-01 0.370 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.270529e-01 0.370 0 0
Regulation of IFNG signaling R-HSA-877312 4.114190e-01 0.386 0 0
Co-stimulation by ICOS R-HSA-9927354 4.752998e-01 0.323 0 0
Signaling by ERBB4 R-HSA-1236394 3.109217e-01 0.507 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.671929e-01 0.435 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.655159e-01 0.437 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.050460e-01 0.392 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.015637e-01 0.521 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.238696e-01 0.490 0 0
Amine ligand-binding receptors R-HSA-375280 4.851471e-01 0.314 0 0
Regulated Necrosis R-HSA-5218859 3.174281e-01 0.498 0 0
Pexophagy R-HSA-9664873 2.939765e-01 0.532 0 0
Nephrin family interactions R-HSA-373753 3.006967e-01 0.522 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.498588e-01 0.456 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.001477e-01 0.523 0 0
Heme signaling R-HSA-9707616 3.242488e-01 0.489 0 0
Signaling by NOTCH R-HSA-157118 2.681502e-01 0.572 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.583131e-01 0.446 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 4.752998e-01 0.323 0 0
tRNA processing in the nucleus R-HSA-6784531 4.401501e-01 0.356 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.008735e-01 0.300 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.729777e-01 0.564 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.752998e-01 0.323 0 0
Syndecan interactions R-HSA-3000170 4.140055e-01 0.383 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.576085e-01 0.447 0 0
G-protein beta:gamma signalling R-HSA-397795 5.008735e-01 0.300 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.084698e-01 0.294 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.617237e-01 0.336 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.343826e-01 0.476 0 0
Other interleukin signaling R-HSA-449836 2.729777e-01 0.564 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.710501e-01 0.567 0 0
DSCAM interactions R-HSA-376172 4.412626e-01 0.355 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.939765e-01 0.532 0 0
Synthesis of PI R-HSA-1483226 3.333448e-01 0.477 0 0
Intracellular oxygen transport R-HSA-8981607 5.169413e-01 0.287 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.169413e-01 0.287 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.655704e-01 0.576 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.741021e-01 0.562 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.288240e-01 0.483 0 0
Histamine receptors R-HSA-390650 5.169413e-01 0.287 0 0
Inflammasomes R-HSA-622312 3.747356e-01 0.426 0 0
Selenocysteine synthesis R-HSA-2408557 2.821513e-01 0.550 0 0
Co-inhibition by BTLA R-HSA-9927353 2.710501e-01 0.567 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.412626e-01 0.355 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.412626e-01 0.355 0 0
Regulation of PTEN localization R-HSA-8948747 4.270529e-01 0.370 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.169413e-01 0.287 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.169413e-01 0.287 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.686328e-01 0.571 0 0
Interleukin-18 signaling R-HSA-9012546 4.752998e-01 0.323 0 0
IRE1alpha activates chaperones R-HSA-381070 5.031035e-01 0.298 0 0
HDL assembly R-HSA-8963896 2.680949e-01 0.572 0 0
Maturation of nucleoprotein R-HSA-9694631 2.729777e-01 0.564 0 0
Specification of primordial germ cells R-HSA-9827857 3.977376e-01 0.400 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 3.243413e-01 0.489 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 3.243413e-01 0.489 0 0
Signal regulatory protein family interactions R-HSA-391160 2.680949e-01 0.572 0 0
FasL/ CD95L signaling R-HSA-75157 5.169413e-01 0.287 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.874730e-01 0.412 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.259136e-01 0.371 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.299702e-01 0.367 0 0
Growth hormone receptor signaling R-HSA-982772 4.140055e-01 0.383 0 0
Influenza Infection R-HSA-168255 2.990648e-01 0.524 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.168958e-01 0.287 0 0
Protein folding R-HSA-391251 5.182620e-01 0.285 0 0
Signaling by TGFB family members R-HSA-9006936 5.185962e-01 0.285 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.209920e-01 0.283 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 5.209920e-01 0.283 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.209920e-01 0.283 0 0
mRNA Editing R-HSA-75072 5.209920e-01 0.283 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 5.209920e-01 0.283 0 0
ARMS-mediated activation R-HSA-170984 5.209920e-01 0.283 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.209920e-01 0.283 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.221539e-01 0.282 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.221539e-01 0.282 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.221539e-01 0.282 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.221539e-01 0.282 0 0
p38MAPK events R-HSA-171007 5.221539e-01 0.282 0 0
Formation of the anterior neural plate R-HSA-9823739 5.221539e-01 0.282 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 5.231653e-01 0.281 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.231653e-01 0.281 0 0
Signalling to RAS R-HSA-167044 5.231653e-01 0.281 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.231653e-01 0.281 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.241689e-01 0.281 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.241689e-01 0.281 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.251666e-01 0.280 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.251666e-01 0.280 0 0
Glycogen metabolism R-HSA-8982491 5.261510e-01 0.279 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.261510e-01 0.279 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.280627e-01 0.277 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.316314e-01 0.274 0 0
Host Interactions of HIV factors R-HSA-162909 5.371679e-01 0.270 0 0
Signaling by GPCR R-HSA-372790 5.399627e-01 0.268 1 0
Organelle biogenesis and maintenance R-HSA-1852241 5.464932e-01 0.262 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.472877e-01 0.262 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.473215e-01 0.262 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.473768e-01 0.262 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.481276e-01 0.261 0 0
Platelet homeostasis R-HSA-418346 5.488682e-01 0.261 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.489674e-01 0.260 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.489674e-01 0.260 0 0
Gap junction assembly R-HSA-190861 5.489674e-01 0.260 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.513230e-01 0.259 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 5.525972e-01 0.258 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.525972e-01 0.258 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.525972e-01 0.258 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.564812e-01 0.255 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.564812e-01 0.255 0 0
Prolonged ERK activation events R-HSA-169893 5.564812e-01 0.255 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.564812e-01 0.255 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.564812e-01 0.255 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.564812e-01 0.255 0 0
Interleukin-1 signaling R-HSA-9020702 5.627778e-01 0.250 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.639364e-01 0.249 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.639364e-01 0.249 0 0
PI3K/AKT activation R-HSA-198203 5.639364e-01 0.249 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.639364e-01 0.249 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.639364e-01 0.249 0 0
Toll-like Receptor Cascades R-HSA-168898 5.648974e-01 0.248 0 0
Intraflagellar transport R-HSA-5620924 5.677802e-01 0.246 0 0
Metal ion SLC transporters R-HSA-425410 5.677802e-01 0.246 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.696585e-01 0.244 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.696585e-01 0.244 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.722148e-01 0.242 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.722148e-01 0.242 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.749509e-01 0.240 0 0
Ribosome-associated quality control R-HSA-9948299 5.751180e-01 0.240 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.757943e-01 0.240 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.790662e-01 0.237 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 5.810354e-01 0.236 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.810354e-01 0.236 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.810354e-01 0.236 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.810354e-01 0.236 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.810354e-01 0.236 0 0
MTF1 activates gene expression R-HSA-5660489 5.823735e-01 0.235 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 5.823735e-01 0.235 0 0
Nucleotide catabolism defects R-HSA-9735786 5.823735e-01 0.235 0 0
Signaling by LRP5 mutants R-HSA-5339717 5.823735e-01 0.235 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.823735e-01 0.235 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 5.823735e-01 0.235 0 0
Regulation of gap junction activity R-HSA-191650 5.823735e-01 0.235 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.823735e-01 0.235 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.823735e-01 0.235 0 0
Dopamine receptors R-HSA-390651 5.823735e-01 0.235 0 0
Transmission across Electrical Synapses R-HSA-112307 5.823735e-01 0.235 0 0
Alanine metabolism R-HSA-8964540 5.823735e-01 0.235 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.823735e-01 0.235 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.823735e-01 0.235 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.823735e-01 0.235 0 0
Sensory perception of sour taste R-HSA-9729555 5.823735e-01 0.235 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.823735e-01 0.235 0 0
TNF signaling R-HSA-75893 5.850256e-01 0.233 0 0
PTEN Regulation R-HSA-6807070 5.870567e-01 0.231 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.892838e-01 0.230 0 0
Phase 2 - plateau phase R-HSA-5576893 5.892838e-01 0.230 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.892838e-01 0.230 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.892838e-01 0.230 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.892838e-01 0.230 0 0
Passive transport by Aquaporins R-HSA-432047 5.892838e-01 0.230 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.892838e-01 0.230 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.906989e-01 0.229 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.948555e-01 0.226 0 0
FLT3 signaling in disease R-HSA-9682385 5.948555e-01 0.226 0 0
Triglyceride catabolism R-HSA-163560 5.948555e-01 0.226 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.980720e-01 0.223 0 0
Insulin receptor signalling cascade R-HSA-74751 6.004352e-01 0.222 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.004661e-01 0.222 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.004661e-01 0.222 0 0
Interferon alpha/beta signaling R-HSA-909733 6.021444e-01 0.220 0 0
IRS-mediated signalling R-HSA-112399 6.032971e-01 0.219 0 0
HCMV Infection R-HSA-9609646 6.038077e-01 0.219 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 6.040393e-01 0.219 0 0
FGFR2b ligand binding and activation R-HSA-190377 6.040393e-01 0.219 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.040393e-01 0.219 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 6.040393e-01 0.219 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 6.040393e-01 0.219 0 0
Formation of the posterior neural plate R-HSA-9832991 6.040393e-01 0.219 0 0
Chylomicron assembly R-HSA-8963888 6.040393e-01 0.219 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 6.040393e-01 0.219 0 0
Suppression of apoptosis R-HSA-9635465 6.040393e-01 0.219 0 0
Prostanoid ligand receptors R-HSA-391908 6.040393e-01 0.219 0 0
LGI-ADAM interactions R-HSA-5682910 6.040393e-01 0.219 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.045243e-01 0.219 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.068122e-01 0.217 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.071120e-01 0.217 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.084041e-01 0.216 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.111101e-01 0.214 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.117849e-01 0.213 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.143942e-01 0.212 0 0
Ion channel transport R-HSA-983712 6.163132e-01 0.210 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.168442e-01 0.210 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.204800e-01 0.207 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.204800e-01 0.207 0 0
S Phase R-HSA-69242 6.209913e-01 0.207 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.243040e-01 0.205 0 0
Signaling by FGFR2 R-HSA-5654738 6.271743e-01 0.203 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.346464e-01 0.197 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.346464e-01 0.197 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.346464e-01 0.197 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.346464e-01 0.197 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.346464e-01 0.197 0 0
MET promotes cell motility R-HSA-8875878 6.381431e-01 0.195 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.381431e-01 0.195 0 0
Extension of Telomeres R-HSA-180786 6.385997e-01 0.195 0 0
Activation of AMPA receptors R-HSA-399710 6.389458e-01 0.195 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.389458e-01 0.195 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.389458e-01 0.195 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.389458e-01 0.195 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.389458e-01 0.195 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 6.389458e-01 0.195 0 0
Activation of AKT2 R-HSA-165158 6.389458e-01 0.195 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.389458e-01 0.195 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.389458e-01 0.195 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.389458e-01 0.195 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.389458e-01 0.195 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.389458e-01 0.195 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.389458e-01 0.195 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.389458e-01 0.195 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.412823e-01 0.193 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.412823e-01 0.193 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 6.412823e-01 0.193 0 0
Integration of provirus R-HSA-162592 6.412823e-01 0.193 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 6.412823e-01 0.193 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.412823e-01 0.193 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.412823e-01 0.193 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.412823e-01 0.193 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.439556e-01 0.191 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.495593e-01 0.187 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.500200e-01 0.187 0 0
Mismatch Repair R-HSA-5358508 6.500200e-01 0.187 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.500200e-01 0.187 0 0
Tie2 Signaling R-HSA-210993 6.500200e-01 0.187 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.505110e-01 0.187 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.587216e-01 0.181 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.597215e-01 0.181 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.597215e-01 0.181 0 0
G protein gated Potassium channels R-HSA-1296059 6.597215e-01 0.181 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.597215e-01 0.181 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.597215e-01 0.181 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.613019e-01 0.180 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.617563e-01 0.179 0 0
Smooth Muscle Contraction R-HSA-445355 6.617563e-01 0.179 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.635026e-01 0.178 0 0
G alpha (q) signalling events R-HSA-416476 6.636468e-01 0.178 1 0
Unfolded Protein Response (UPR) R-HSA-381119 6.686135e-01 0.175 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 6.692500e-01 0.174 1 1
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.692500e-01 0.174 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.692500e-01 0.174 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.693241e-01 0.174 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.693241e-01 0.174 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.708661e-01 0.173 0 0
Aquaporin-mediated transport R-HSA-445717 6.721061e-01 0.173 0 0
MAP kinase activation R-HSA-450294 6.721061e-01 0.173 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.721061e-01 0.173 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.731193e-01 0.172 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.757044e-01 0.170 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.757044e-01 0.170 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.757044e-01 0.170 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.757044e-01 0.170 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.757044e-01 0.170 0 0
Estrogen biosynthesis R-HSA-193144 6.757044e-01 0.170 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.757044e-01 0.170 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.757044e-01 0.170 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.757044e-01 0.170 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.767665e-01 0.170 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.778808e-01 0.169 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.778808e-01 0.169 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.778808e-01 0.169 0 0
HIV Transcription Elongation R-HSA-167169 6.785560e-01 0.168 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.785560e-01 0.168 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.785560e-01 0.168 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.785560e-01 0.168 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.785560e-01 0.168 0 0
Attenuation phase R-HSA-3371568 6.785560e-01 0.168 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.836041e-01 0.165 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.836041e-01 0.165 0 0
Plus-strand DNA synthesis R-HSA-164525 6.878576e-01 0.163 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.878576e-01 0.163 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.878576e-01 0.163 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.878576e-01 0.163 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.878576e-01 0.163 0 0
PKB-mediated events R-HSA-109703 6.878576e-01 0.163 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.878576e-01 0.163 0 0
PDE3B signalling R-HSA-165160 6.878576e-01 0.163 0 0
Signaling by MAPK mutants R-HSA-9652817 6.878576e-01 0.163 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.878576e-01 0.163 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.878576e-01 0.163 0 0
Synthesis of PS R-HSA-1483101 6.878576e-01 0.163 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.878576e-01 0.163 0 0
Ceramide signalling R-HSA-193681 6.878576e-01 0.163 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.878576e-01 0.163 0 0
Formation of the Editosome R-HSA-75094 6.878576e-01 0.163 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.878576e-01 0.163 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.878576e-01 0.163 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.878576e-01 0.163 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.878576e-01 0.163 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.878576e-01 0.163 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.878576e-01 0.163 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 6.881436e-01 0.162 0 0
Signaling by PDGF R-HSA-186797 6.881436e-01 0.162 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.901816e-01 0.161 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.904538e-01 0.161 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.967196e-01 0.157 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.967196e-01 0.157 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.976287e-01 0.156 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.040627e-01 0.152 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.040627e-01 0.152 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.040627e-01 0.152 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.062819e-01 0.151 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.062819e-01 0.151 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.062819e-01 0.151 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.062819e-01 0.151 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.073862e-01 0.150 0 0
FGFR2c ligand binding and activation R-HSA-190375 7.073862e-01 0.150 0 0
Interleukin-6 signaling R-HSA-1059683 7.073862e-01 0.150 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.073862e-01 0.150 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 7.073862e-01 0.150 0 0
FGFR4 ligand binding and activation R-HSA-190322 7.073862e-01 0.150 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 7.073862e-01 0.150 0 0
FGFR3 mutant receptor activation R-HSA-2033514 7.073862e-01 0.150 0 0
Processing of SMDT1 R-HSA-8949664 7.073862e-01 0.150 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.073862e-01 0.150 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.073862e-01 0.150 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.106429e-01 0.148 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.106429e-01 0.148 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.109440e-01 0.148 0 0
Mitochondrial biogenesis R-HSA-1592230 7.135819e-01 0.147 0 0
HIV Life Cycle R-HSA-162587 7.152895e-01 0.146 0 0
Translation of Structural Proteins R-HSA-9683701 7.159284e-01 0.145 0 0
SARS-CoV Infections R-HSA-9679506 7.187890e-01 0.143 0 0
Degradation of CDH1 R-HSA-9766229 7.216101e-01 0.142 0 0
Nucleotide Excision Repair R-HSA-5696398 7.219283e-01 0.142 0 0
Cellular response to starvation R-HSA-9711097 7.248589e-01 0.140 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.253763e-01 0.139 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.277543e-01 0.138 0 0
HIV elongation arrest and recovery R-HSA-167287 7.277543e-01 0.138 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.277543e-01 0.138 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.277543e-01 0.138 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.285846e-01 0.138 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.285846e-01 0.138 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.285846e-01 0.138 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.285846e-01 0.138 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.285846e-01 0.138 0 0
Basigin interactions R-HSA-210991 7.285846e-01 0.138 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.285846e-01 0.138 0 0
Signaling by LTK in cancer R-HSA-9842640 7.301458e-01 0.137 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.301458e-01 0.137 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 7.301458e-01 0.137 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.301458e-01 0.137 0 0
Uncoating of the HIV Virion R-HSA-162585 7.301458e-01 0.137 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.301458e-01 0.137 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.301458e-01 0.137 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.301458e-01 0.137 0 0
Abacavir transmembrane transport R-HSA-2161517 7.301458e-01 0.137 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.301458e-01 0.137 0 0
VLDL assembly R-HSA-8866423 7.301458e-01 0.137 0 0
Lipid particle organization R-HSA-8964572 7.301458e-01 0.137 0 0
Leukotriene receptors R-HSA-391906 7.301458e-01 0.137 0 0
Neurofascin interactions R-HSA-447043 7.301458e-01 0.137 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.320723e-01 0.135 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.353741e-01 0.133 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.364385e-01 0.133 0 0
Removal of the Flap Intermediate R-HSA-69166 7.364385e-01 0.133 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.364385e-01 0.133 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.364385e-01 0.133 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.364385e-01 0.133 0 0
FGFR3c ligand binding and activation R-HSA-190372 7.364385e-01 0.133 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 7.364385e-01 0.133 0 0
Prolactin receptor signaling R-HSA-1170546 7.364385e-01 0.133 0 0
Zinc transporters R-HSA-435354 7.364385e-01 0.133 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.364385e-01 0.133 0 0
Circadian clock R-HSA-9909396 7.377950e-01 0.132 0 0
Ca2+ pathway R-HSA-4086398 7.390188e-01 0.131 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.424194e-01 0.129 0 0
DNA Replication R-HSA-69306 7.465592e-01 0.127 0 0
Signaling by Erythropoietin R-HSA-9006335 7.480310e-01 0.126 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.480310e-01 0.126 0 0
HSF1 activation R-HSA-3371511 7.481853e-01 0.126 0 0
RUNX2 regulates bone development R-HSA-8941326 7.481853e-01 0.126 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.514808e-01 0.124 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.521988e-01 0.124 0 0
Signaling by NOTCH4 R-HSA-9013694 7.521988e-01 0.124 0 0
The phototransduction cascade R-HSA-2514856 7.532144e-01 0.123 1 0
Leishmania phagocytosis R-HSA-9664417 7.535279e-01 0.123 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.535279e-01 0.123 0 0
Parasite infection R-HSA-9664407 7.535279e-01 0.123 0 0
Kidney development R-HSA-9830369 7.607764e-01 0.119 0 0
Erythropoietin activates RAS R-HSA-9027284 7.629921e-01 0.117 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.629921e-01 0.117 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.629921e-01 0.117 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.629921e-01 0.117 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.629921e-01 0.117 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.629921e-01 0.117 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.629921e-01 0.117 0 0
Protein ubiquitination R-HSA-8852135 7.649144e-01 0.116 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.649144e-01 0.116 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.655478e-01 0.116 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.667071e-01 0.115 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.667071e-01 0.115 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.667071e-01 0.115 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.667071e-01 0.115 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.667071e-01 0.115 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.667071e-01 0.115 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.667071e-01 0.115 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.667071e-01 0.115 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.667071e-01 0.115 0 0
LDL remodeling R-HSA-8964041 7.667071e-01 0.115 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.667071e-01 0.115 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.667071e-01 0.115 0 0
Activation of the pre-replicative complex R-HSA-68962 7.671301e-01 0.115 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.671301e-01 0.115 0 0
DAP12 signaling R-HSA-2424491 7.671301e-01 0.115 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.671301e-01 0.115 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.680195e-01 0.115 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.680195e-01 0.115 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.691467e-01 0.114 0 0
FGFR2 alternative splicing R-HSA-6803529 7.727982e-01 0.112 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.727982e-01 0.112 0 0
Transcription of the HIV genome R-HSA-167172 7.737618e-01 0.111 0 0
TCR signaling R-HSA-202403 7.761592e-01 0.110 1 0
Selenoamino acid metabolism R-HSA-2408522 7.780904e-01 0.109 0 0
HCMV Late Events R-HSA-9610379 7.816256e-01 0.107 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.819867e-01 0.107 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.850770e-01 0.105 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.850770e-01 0.105 0 0
Cargo concentration in the ER R-HSA-5694530 7.850770e-01 0.105 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.871907e-01 0.104 0 0
Atorvastatin ADME R-HSA-9754706 7.871907e-01 0.104 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.871907e-01 0.104 0 0
Regulation of BACH1 activity R-HSA-9708530 7.871907e-01 0.104 0 0
Differentiation of T cells R-HSA-9945266 7.871907e-01 0.104 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.871907e-01 0.104 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.871907e-01 0.104 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.925930e-01 0.101 0 0
Inositol phosphate metabolism R-HSA-1483249 7.956799e-01 0.099 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.957783e-01 0.099 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.957783e-01 0.099 0 0
Stabilization of p53 R-HSA-69541 7.975196e-01 0.098 0 0
Interleukin-17 signaling R-HSA-448424 7.981955e-01 0.098 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.983166e-01 0.098 0 0
Minus-strand DNA synthesis R-HSA-164516 7.983166e-01 0.098 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.983166e-01 0.098 0 0
phospho-PLA2 pathway R-HSA-111995 7.983166e-01 0.098 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.983166e-01 0.098 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.983166e-01 0.098 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.983166e-01 0.098 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.983166e-01 0.098 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.983166e-01 0.098 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.983166e-01 0.098 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.983166e-01 0.098 0 0
Alpha-defensins R-HSA-1462054 7.983166e-01 0.098 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.983166e-01 0.098 0 0
Interleukin-23 signaling R-HSA-9020933 7.983166e-01 0.098 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.983271e-01 0.098 0 0
Signaling by FGFR R-HSA-190236 7.983271e-01 0.098 0 0
G1/S Transition R-HSA-69206 8.030781e-01 0.095 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.091848e-01 0.092 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.091848e-01 0.092 0 0
Synthesis of PG R-HSA-1483148 8.091848e-01 0.092 0 0
Hedgehog 'on' state R-HSA-5632684 8.096532e-01 0.092 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.109283e-01 0.091 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.121679e-01 0.090 0 0
Generation of second messenger molecules R-HSA-202433 8.121679e-01 0.090 0 0
Nuclear RNA decay R-HSA-9930044 8.176447e-01 0.087 0 0
Platelet degranulation R-HSA-114608 8.199534e-01 0.086 0 0
Signaling by MET R-HSA-6806834 8.215832e-01 0.085 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.256448e-01 0.083 0 0
Interleukin-21 signaling R-HSA-9020958 8.256448e-01 0.083 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.256448e-01 0.083 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.256448e-01 0.083 0 0
Unwinding of DNA R-HSA-176974 8.256448e-01 0.083 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.256448e-01 0.083 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.256448e-01 0.083 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.256448e-01 0.083 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.256448e-01 0.083 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.278728e-01 0.082 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.278728e-01 0.082 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.291276e-01 0.081 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.291276e-01 0.081 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.291276e-01 0.081 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.291276e-01 0.081 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.291276e-01 0.081 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 8.291276e-01 0.081 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.291276e-01 0.081 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.291276e-01 0.081 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.291276e-01 0.081 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.291276e-01 0.081 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.291276e-01 0.081 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.323417e-01 0.080 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.389124e-01 0.076 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.389124e-01 0.076 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.389124e-01 0.076 0 0
Intra-Golgi traffic R-HSA-6811438 8.389124e-01 0.076 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.389124e-01 0.076 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.434981e-01 0.074 0 0
Dual Incision in GG-NER R-HSA-5696400 8.460370e-01 0.073 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.460370e-01 0.073 0 0
Signaling by NOTCH2 R-HSA-1980145 8.460370e-01 0.073 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.471710e-01 0.072 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.471710e-01 0.072 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.471710e-01 0.072 0 0
Binding and entry of HIV virion R-HSA-173107 8.492715e-01 0.071 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.492715e-01 0.071 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.492715e-01 0.071 0 0
Formation of apoptosome R-HSA-111458 8.492715e-01 0.071 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.492715e-01 0.071 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.492715e-01 0.071 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.492715e-01 0.071 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.492715e-01 0.071 0 0
Interleukin-27 signaling R-HSA-9020956 8.492715e-01 0.071 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.492715e-01 0.071 0 0
Arachidonate production from DAG R-HSA-426048 8.492715e-01 0.071 0 0
2-LTR circle formation R-HSA-164843 8.492715e-01 0.071 0 0
Maturation of spike protein R-HSA-9683686 8.492715e-01 0.071 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.492715e-01 0.071 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.492715e-01 0.071 0 0
Josephin domain DUBs R-HSA-5689877 8.492715e-01 0.071 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.509935e-01 0.070 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.537333e-01 0.069 0 0
Triglyceride metabolism R-HSA-8979227 8.537333e-01 0.069 0 0
Developmental Cell Lineages R-HSA-9734767 8.539575e-01 0.069 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.571312e-01 0.067 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.578776e-01 0.067 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.578776e-01 0.067 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.578776e-01 0.067 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.578776e-01 0.067 0 0
PERK regulates gene expression R-HSA-381042 8.587753e-01 0.066 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.587753e-01 0.066 0 0
HIV Infection R-HSA-162906 8.618456e-01 0.065 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.634634e-01 0.064 0 0
Regulation of signaling by CBL R-HSA-912631 8.634634e-01 0.064 0 0
Translesion Synthesis by POLH R-HSA-110320 8.634634e-01 0.064 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.634634e-01 0.064 0 0
Translation of Structural Proteins R-HSA-9694635 8.682795e-01 0.061 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.696976e-01 0.061 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.696976e-01 0.061 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.696976e-01 0.061 0 0
vRNA Synthesis R-HSA-192814 8.696976e-01 0.061 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.696976e-01 0.061 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.696976e-01 0.061 0 0
Bicarbonate transporters R-HSA-425381 8.696976e-01 0.061 0 0
Transport of RCbl within the body R-HSA-9758890 8.696976e-01 0.061 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.696976e-01 0.061 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.696976e-01 0.061 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.696976e-01 0.061 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.696976e-01 0.061 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.710856e-01 0.060 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.710856e-01 0.060 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.710856e-01 0.060 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.710856e-01 0.060 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.733038e-01 0.059 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.770118e-01 0.057 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.781481e-01 0.056 0 0
Glycogen synthesis R-HSA-3322077 8.781481e-01 0.056 0 0
Signaling by NODAL R-HSA-1181150 8.781481e-01 0.056 0 0
Negative regulation of MET activity R-HSA-6807004 8.781481e-01 0.056 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.811541e-01 0.055 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.816351e-01 0.055 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.830220e-01 0.054 0 0
mRNA Capping R-HSA-72086 8.831958e-01 0.054 0 0
Late endosomal microautophagy R-HSA-9615710 8.831958e-01 0.054 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.831958e-01 0.054 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.831958e-01 0.054 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.865661e-01 0.052 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.865661e-01 0.052 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.873568e-01 0.052 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.873568e-01 0.052 0 0
ERKs are inactivated R-HSA-202670 8.873568e-01 0.052 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.873568e-01 0.052 0 0
FMO oxidises nucleophiles R-HSA-217271 8.873568e-01 0.052 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.873568e-01 0.052 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.875075e-01 0.052 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.913614e-01 0.050 0 0
G-protein activation R-HSA-202040 8.913614e-01 0.050 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.913614e-01 0.050 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.913614e-01 0.050 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.913614e-01 0.050 0 0
Lagging Strand Synthesis R-HSA-69186 8.913614e-01 0.050 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 8.913614e-01 0.050 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.913614e-01 0.050 0 0
ERK/MAPK targets R-HSA-198753 8.913614e-01 0.050 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.913614e-01 0.050 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 8.913614e-01 0.050 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.922831e-01 0.049 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.942806e-01 0.049 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.942806e-01 0.049 0 0
Signaling by NOTCH3 R-HSA-9012852 8.945154e-01 0.048 0 0
Ion transport by P-type ATPases R-HSA-936837 8.976529e-01 0.047 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.009044e-01 0.045 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.010886e-01 0.045 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.024393e-01 0.045 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.024393e-01 0.045 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 9.026235e-01 0.044 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 9.026235e-01 0.044 0 0
Scavenging by Class F Receptors R-HSA-3000484 9.026235e-01 0.044 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 9.026235e-01 0.044 0 0
IRAK1 recruits IKK complex R-HSA-937039 9.026235e-01 0.044 0 0
GRB2 events in EGFR signaling R-HSA-179812 9.026235e-01 0.044 0 0
Interleukin-35 Signalling R-HSA-8984722 9.026235e-01 0.044 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.026235e-01 0.044 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.026235e-01 0.044 0 0
MET activates RAS signaling R-HSA-8851805 9.026235e-01 0.044 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 9.026235e-01 0.044 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.026235e-01 0.044 0 0
Polymerase switching R-HSA-69091 9.026235e-01 0.044 0 0
Leading Strand Synthesis R-HSA-69109 9.026235e-01 0.044 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.026235e-01 0.044 0 0
ER-Phagosome pathway R-HSA-1236974 9.030010e-01 0.044 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.032324e-01 0.044 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.032324e-01 0.044 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.032324e-01 0.044 0 0
Attachment and Entry R-HSA-9694614 9.032324e-01 0.044 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.032324e-01 0.044 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.044107e-01 0.044 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.044107e-01 0.044 0 0
Signaling by FGFR in disease R-HSA-1226099 9.080058e-01 0.042 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.097398e-01 0.041 0 0
DNA strand elongation R-HSA-69190 9.136543e-01 0.039 0 0
Signaling by KIT in disease R-HSA-9669938 9.138821e-01 0.039 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.138821e-01 0.039 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.138821e-01 0.039 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.138821e-01 0.039 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.138821e-01 0.039 0 0
Free fatty acid receptors R-HSA-444209 9.138821e-01 0.039 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.138821e-01 0.039 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.138821e-01 0.039 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.138821e-01 0.039 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.143412e-01 0.039 0 0
PPARA activates gene expression R-HSA-1989781 9.144093e-01 0.039 0 0
Acetylcholine binding and downstream events R-HSA-181431 9.158219e-01 0.038 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 9.158219e-01 0.038 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.158219e-01 0.038 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.158219e-01 0.038 0 0
Chylomicron remodeling R-HSA-8963901 9.158219e-01 0.038 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.158219e-01 0.038 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.158219e-01 0.038 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.158219e-01 0.038 0 0
CD28 dependent Vav1 pathway R-HSA-389359 9.158219e-01 0.038 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.158219e-01 0.038 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.163603e-01 0.038 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.167594e-01 0.038 0 0
Maturation of spike protein R-HSA-9694548 9.177113e-01 0.037 0 0
Phospholipid metabolism R-HSA-1483257 9.219187e-01 0.035 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.227662e-01 0.035 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.234235e-01 0.035 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.234235e-01 0.035 0 0
Interleukin-20 family signaling R-HSA-8854691 9.234235e-01 0.035 0 0
Formation of the ureteric bud R-HSA-9830674 9.234235e-01 0.035 0 0
Biosynthesis of maresins R-HSA-9018682 9.234235e-01 0.035 0 0
Signaling by Insulin receptor R-HSA-74752 9.254691e-01 0.034 0 0
Potential therapeutics for SARS R-HSA-9679191 9.267703e-01 0.033 0 0
Signaling by FGFR4 in disease R-HSA-5655291 9.272321e-01 0.033 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.272321e-01 0.033 0 0
Hydrolysis of LPC R-HSA-1483115 9.272321e-01 0.033 0 0
Biosynthesis of protectins R-HSA-9018681 9.272321e-01 0.033 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.272321e-01 0.033 0 0
Physiological factors R-HSA-5578768 9.272321e-01 0.033 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.272321e-01 0.033 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.272321e-01 0.033 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.272321e-01 0.033 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.272321e-01 0.033 0 0
P2Y receptors R-HSA-417957 9.272321e-01 0.033 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.317878e-01 0.031 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.317878e-01 0.031 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.317878e-01 0.031 0 0
Interleukin-6 family signaling R-HSA-6783589 9.319612e-01 0.031 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.319612e-01 0.031 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.347965e-01 0.029 0 0
COPII-mediated vesicle transport R-HSA-204005 9.350906e-01 0.029 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.367061e-01 0.028 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.367061e-01 0.028 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.370962e-01 0.028 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.370962e-01 0.028 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.370962e-01 0.028 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.370962e-01 0.028 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.370962e-01 0.028 0 0
Translesion synthesis by REV1 R-HSA-110312 9.370962e-01 0.028 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.370962e-01 0.028 0 0
Signaling by Activin R-HSA-1502540 9.370962e-01 0.028 0 0
Transport and metabolism of PAPS R-HSA-174362 9.370962e-01 0.028 0 0
Biotin transport and metabolism R-HSA-196780 9.370962e-01 0.028 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.370962e-01 0.028 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.370962e-01 0.028 0 0
Other semaphorin interactions R-HSA-416700 9.370962e-01 0.028 0 0
DNA Damage Reversal R-HSA-73942 9.370962e-01 0.028 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.379754e-01 0.028 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.379754e-01 0.028 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.410236e-01 0.026 0 0
DAP12 interactions R-HSA-2172127 9.436481e-01 0.025 0 0
Viral Infection Pathways R-HSA-9824446 9.436774e-01 0.025 0 0
Translesion synthesis by POLI R-HSA-5656121 9.456236e-01 0.024 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.456236e-01 0.024 0 0
Fructose catabolism R-HSA-70350 9.456236e-01 0.024 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.456236e-01 0.024 0 0
Attachment and Entry R-HSA-9678110 9.456236e-01 0.024 0 0
MET activates PTK2 signaling R-HSA-8874081 9.464050e-01 0.024 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.464050e-01 0.024 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.464050e-01 0.024 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.487592e-01 0.023 0 0
RNA Polymerase III Transcription R-HSA-74158 9.487592e-01 0.023 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.487592e-01 0.023 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.487592e-01 0.023 0 0
Glycosphingolipid transport R-HSA-9845576 9.487592e-01 0.023 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.488429e-01 0.023 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.488429e-01 0.023 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.507126e-01 0.022 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.516595e-01 0.022 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.524814e-01 0.021 0 0
Cristae formation R-HSA-8949613 9.524814e-01 0.021 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.524814e-01 0.021 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.529955e-01 0.021 0 0
Translesion synthesis by POLK R-HSA-5655862 9.529955e-01 0.021 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.529955e-01 0.021 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.529955e-01 0.021 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.529955e-01 0.021 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.529955e-01 0.021 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.529955e-01 0.021 0 0
Vitamin B6 activation to pyridoxal phosphate R-HSA-964975 9.529955e-01 0.021 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.529955e-01 0.021 0 0
Galactose catabolism R-HSA-70370 9.529955e-01 0.021 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.529955e-01 0.021 0 0
Response to metal ions R-HSA-5660526 9.529955e-01 0.021 0 0
Neddylation R-HSA-8951664 9.536379e-01 0.021 0 0
Degradation of DVL R-HSA-4641258 9.539494e-01 0.020 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.549935e-01 0.020 0 0
Prednisone ADME R-HSA-9757110 9.578958e-01 0.019 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.579832e-01 0.019 0 0
Elastic fibre formation R-HSA-1566948 9.586445e-01 0.018 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.587415e-01 0.018 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.593683e-01 0.018 0 0
Glycogen storage diseases R-HSA-3229121 9.593683e-01 0.018 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.593683e-01 0.018 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.593683e-01 0.018 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.593683e-01 0.018 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.597998e-01 0.018 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.605230e-01 0.017 0 0
Dual incision in TC-NER R-HSA-6782135 9.625531e-01 0.017 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.626866e-01 0.017 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.627159e-01 0.017 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.627159e-01 0.017 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.628874e-01 0.016 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.628874e-01 0.016 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.640915e-01 0.016 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.648774e-01 0.016 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.648774e-01 0.016 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.648774e-01 0.016 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.648774e-01 0.016 0 0
Nephron development R-HSA-9831926 9.648774e-01 0.016 0 0
G alpha (i) signalling events R-HSA-418594 9.654772e-01 0.015 0 0
Regulation of beta-cell development R-HSA-186712 9.658781e-01 0.015 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.667179e-01 0.015 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.667179e-01 0.015 0 0
Neurotransmitter clearance R-HSA-112311 9.670034e-01 0.015 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.670034e-01 0.015 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.670034e-01 0.015 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.687640e-01 0.014 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.688083e-01 0.014 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.696399e-01 0.013 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.696399e-01 0.013 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.699533e-01 0.013 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.699533e-01 0.013 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.701730e-01 0.013 0 0
Budding and maturation of HIV virion R-HSA-162588 9.708139e-01 0.013 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.718059e-01 0.012 0 0
RSV-host interactions R-HSA-9833110 9.725838e-01 0.012 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.732865e-01 0.012 0 0
HIV Transcription Initiation R-HSA-167161 9.732865e-01 0.012 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.732865e-01 0.012 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.737568e-01 0.012 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.737568e-01 0.012 0 0
Creatine metabolism R-HSA-71288 9.737568e-01 0.012 0 0
Keratan sulfate degradation R-HSA-2022857 9.737568e-01 0.012 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.737568e-01 0.012 0 0
Pregnenolone biosynthesis R-HSA-196108 9.737568e-01 0.012 0 0
HS-GAG degradation R-HSA-2024096 9.741981e-01 0.011 0 0
Mitochondrial protein import R-HSA-1268020 9.742871e-01 0.011 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.742871e-01 0.011 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.745320e-01 0.011 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.745320e-01 0.011 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.745320e-01 0.011 0 0
Downstream TCR signaling R-HSA-202424 9.750668e-01 0.011 1 1
Neurotransmitter release cycle R-HSA-112310 9.750668e-01 0.011 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.769954e-01 0.010 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.770091e-01 0.010 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.772014e-01 0.010 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.773156e-01 0.010 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.781721e-01 0.010 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.786120e-01 0.009 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.798648e-01 0.009 0 0
Heme degradation R-HSA-189483 9.798648e-01 0.009 0 0
Glutathione synthesis and recycling R-HSA-174403 9.803920e-01 0.009 0 0
Ribavirin ADME R-HSA-9755088 9.803920e-01 0.009 0 0
Assembly Of The HIV Virion R-HSA-175474 9.803920e-01 0.009 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.805578e-01 0.009 0 0
Cellular response to hypoxia R-HSA-1234174 9.807332e-01 0.008 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.808791e-01 0.008 0 0
Surfactant metabolism R-HSA-5683826 9.808791e-01 0.008 0 0
eNOS activation R-HSA-203615 9.822254e-01 0.008 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.822254e-01 0.008 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.829156e-01 0.007 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.829156e-01 0.007 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.830514e-01 0.007 0 0
LDL clearance R-HSA-8964038 9.830514e-01 0.007 0 0
Fructose metabolism R-HSA-5652084 9.830514e-01 0.007 0 0
Gastrulation R-HSA-9758941 9.831591e-01 0.007 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.843700e-01 0.007 0 0
Synthesis of PA R-HSA-1483166 9.848230e-01 0.007 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.853502e-01 0.006 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.853502e-01 0.006 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.853502e-01 0.006 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.853502e-01 0.006 0 0
Carnitine shuttle R-HSA-200425 9.853502e-01 0.006 0 0
PCP/CE pathway R-HSA-4086400 9.854887e-01 0.006 0 0
Integrin cell surface interactions R-HSA-216083 9.854887e-01 0.006 0 0
Cholesterol biosynthesis R-HSA-191273 9.854887e-01 0.006 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.861670e-01 0.006 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.863830e-01 0.006 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.863830e-01 0.006 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.864344e-01 0.006 1 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.873373e-01 0.006 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.873373e-01 0.006 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.873373e-01 0.006 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.873373e-01 0.006 0 0
Complex III assembly R-HSA-9865881 9.873373e-01 0.006 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.878044e-01 0.005 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.878044e-01 0.005 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.878044e-01 0.005 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.878044e-01 0.005 0 0
NCAM1 interactions R-HSA-419037 9.878044e-01 0.005 0 0
tRNA Aminoacylation R-HSA-379724 9.889502e-01 0.005 0 0
Hyaluronan degradation R-HSA-2160916 9.890550e-01 0.005 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.890550e-01 0.005 0 0
Laminin interactions R-HSA-3000157 9.890550e-01 0.005 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.890550e-01 0.005 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.890550e-01 0.005 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.892522e-01 0.005 0 0
Purine salvage R-HSA-74217 9.892522e-01 0.005 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.892522e-01 0.005 0 0
Collagen degradation R-HSA-1442490 9.900699e-01 0.004 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.905318e-01 0.004 0 0
RAS processing R-HSA-9648002 9.905318e-01 0.004 1 1
Urea cycle R-HSA-70635 9.905398e-01 0.004 0 0
Abacavir ADME R-HSA-2161522 9.905398e-01 0.004 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.909694e-01 0.004 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.916266e-01 0.004 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.916620e-01 0.004 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.918232e-01 0.004 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.918232e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.918232e-01 0.004 0 0
Insulin processing R-HSA-264876 9.918232e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.918232e-01 0.004 0 0
Signaling by BMP R-HSA-201451 9.918232e-01 0.004 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.920342e-01 0.003 0 0
Orc1 removal from chromatin R-HSA-68949 9.923440e-01 0.003 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.926600e-01 0.003 0 0
Pyrimidine salvage R-HSA-73614 9.929326e-01 0.003 0 0
Mitochondrial protein degradation R-HSA-9837999 9.931138e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.938915e-01 0.003 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.938915e-01 0.003 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.938915e-01 0.003 0 0
Glucagon-type ligand receptors R-HSA-420092 9.938915e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.942219e-01 0.003 0 0
Mucopolysaccharidoses R-HSA-2206281 9.947203e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.947889e-01 0.002 0 0
Nicotinate metabolism R-HSA-196807 9.948222e-01 0.002 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.950027e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.953621e-01 0.002 0 0
SLC transporter disorders R-HSA-5619102 9.953848e-01 0.002 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.954368e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.954368e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.956065e-01 0.002 0 0
Synthesis of DNA R-HSA-69239 9.956406e-01 0.002 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.961385e-01 0.002 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.961385e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.961385e-01 0.002 0 0
Innate Immune System R-HSA-168249 9.961941e-01 0.002 1 0
Peptide hormone metabolism R-HSA-2980736 9.963690e-01 0.002 0 0
Post-translational protein modification R-HSA-597592 9.964163e-01 0.002 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.965913e-01 0.001 0 0
tRNA processing R-HSA-72306 9.965944e-01 0.001 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.966070e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.966431e-01 0.001 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.966431e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.966753e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.966753e-01 0.001 0 0
Protein localization R-HSA-9609507 9.967675e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.970196e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.970196e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.970207e-01 0.001 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.970207e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.970268e-01 0.001 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.970539e-01 0.001 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.970539e-01 0.001 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.973567e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.973567e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.973827e-01 0.001 0 0
Gluconeogenesis R-HSA-70263 9.973827e-01 0.001 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.974538e-01 0.001 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.974538e-01 0.001 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.974538e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.974538e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.975099e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.976252e-01 0.001 0 0
Regulation of Apoptosis R-HSA-169911 9.977994e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.977994e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.978788e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.979865e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.980672e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.980778e-01 0.001 0 0
HS-GAG biosynthesis R-HSA-2022928 9.980981e-01 0.001 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.980981e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.982939e-01 0.001 0 0
Degradation of AXIN R-HSA-4641257 9.983563e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.983563e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.983563e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.987199e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.987723e-01 0.001 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.987723e-01 0.001 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.988058e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.988822e-01 0.000 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.989390e-01 0.000 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.989390e-01 0.000 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.990831e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.990831e-01 0.000 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.990831e-01 0.000 0 0
Disease R-HSA-1643685 9.991059e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.991958e-01 0.000 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.992076e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.992076e-01 0.000 0 0
Heme biosynthesis R-HSA-189451 9.992076e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.992154e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.992154e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.993828e-01 0.000 0 0
Defensins R-HSA-1461973 9.994082e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.994654e-01 0.000 1 1
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.994886e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.994926e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.995213e-01 0.000 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.995580e-01 0.000 0 0
Somitogenesis R-HSA-9824272 9.995580e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.995961e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.995974e-01 0.000 1 0
Regulation of pyruvate metabolism R-HSA-9861718 9.996181e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.996547e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.996703e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.996826e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.996826e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.997535e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.997535e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.997735e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.997735e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.997870e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.997874e-01 0.000 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.998160e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.998160e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998249e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998578e-01 0.000 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.998626e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.998626e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998717e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998757e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998914e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.998974e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999051e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999064e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999106e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999113e-01 0.000 0 0
Digestion R-HSA-8935690 9.999113e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999220e-01 0.000 0 0
Translation R-HSA-72766 9.999232e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.999388e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999428e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.999428e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999506e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999573e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999681e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999681e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999711e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999762e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999785e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999786e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999793e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999817e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999822e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999858e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.999885e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999892e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999918e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999926e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999927e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999936e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999952e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999955e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999969e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999989e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999991e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999992e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999995e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999997e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999998e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999998e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999998e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999999e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 1 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.110223e-16 15.955 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.110223e-16 15.955 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.110223e-16 15.955 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.110223e-16 15.955 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.110223e-16 15.955 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 1 0
Nervous system development R-HSA-9675108 1.110223e-16 15.955 1 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.220446e-16 15.654 0 0
Metabolism of RNA R-HSA-8953854 4.440892e-16 15.353 0 0
Peptide chain elongation R-HSA-156902 7.771561e-16 15.109 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.771561e-16 15.109 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.110223e-15 14.955 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.884182e-15 14.230 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.365574e-14 13.865 0 0
Signaling by ROBO receptors R-HSA-376176 2.031708e-14 13.692 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.109424e-14 13.676 0 0
M Phase R-HSA-68886 3.386180e-14 13.470 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.107825e-14 13.386 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.907186e-14 13.309 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.547918e-14 13.020 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.547918e-14 13.020 0 0
Influenza Infection R-HSA-168255 2.211564e-13 12.655 0 0
Eukaryotic Translation Termination R-HSA-72764 2.933209e-13 12.533 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.056444e-13 12.515 0 0
Ribosome-associated quality control R-HSA-9948299 8.327783e-13 12.079 0 0
Selenocysteine synthesis R-HSA-2408557 1.812772e-12 11.742 0 0
rRNA processing R-HSA-72312 2.677303e-12 11.572 0 0
Viral mRNA Translation R-HSA-192823 3.230416e-12 11.491 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.740430e-12 11.324 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.690670e-12 11.245 0 0
Translation initiation complex formation R-HSA-72649 6.124878e-12 11.213 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.576517e-12 11.182 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.360756e-11 10.866 0 0
Cellular response to heat stress R-HSA-3371556 2.165235e-11 10.664 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.971712e-11 10.401 0 0
HSF1-dependent transactivation R-HSA-3371571 3.924150e-11 10.406 0 0
L1CAM interactions R-HSA-373760 6.541023e-11 10.184 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.276731e-10 9.894 0 0
Attenuation phase R-HSA-3371568 1.329459e-10 9.876 0 0
Cellular Senescence R-HSA-2559583 1.386541e-10 9.858 0 0
Recycling pathway of L1 R-HSA-437239 1.681182e-10 9.774 0 0
Cell Cycle Checkpoints R-HSA-69620 2.014466e-10 9.696 0 0
Cellular response to starvation R-HSA-9711097 2.539572e-10 9.595 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.652489e-10 9.437 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.760666e-10 9.425 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.775094e-10 9.321 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.299821e-10 9.276 0 0
PKR-mediated signaling R-HSA-9833482 6.503234e-10 9.187 0 0
Diseases of programmed cell death R-HSA-9645723 6.525790e-10 9.185 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.541899e-10 9.184 0 0
Signal Transduction R-HSA-162582 8.735439e-10 9.059 1 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.310928e-10 9.031 0 0
Viral Infection Pathways R-HSA-9824446 1.110041e-09 8.955 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.035696e-09 8.691 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.005867e-09 8.698 0 0
Cell-Cell communication R-HSA-1500931 2.234696e-09 8.651 0 0
G2/M Transition R-HSA-69275 2.723554e-09 8.565 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.743041e-09 8.562 0 0
G2/M Checkpoints R-HSA-69481 2.968122e-09 8.528 0 0
Aggrephagy R-HSA-9646399 3.096124e-09 8.509 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.493548e-09 8.457 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.805560e-09 8.420 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.736616e-09 8.111 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.878532e-09 8.005 0 0
Estrogen-dependent gene expression R-HSA-9018519 9.517382e-09 8.021 0 0
Apoptotic execution phase R-HSA-75153 9.878532e-09 8.005 1 0
DNA methylation R-HSA-5334118 1.012398e-08 7.995 0 0
Mitotic Anaphase R-HSA-68882 1.065697e-08 7.972 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.078471e-08 7.967 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.159309e-08 7.936 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.199013e-08 7.921 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.236268e-08 7.908 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.331987e-08 7.876 0 0
HSF1 activation R-HSA-3371511 1.331987e-08 7.876 0 0
Mitotic Prophase R-HSA-68875 1.329110e-08 7.876 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.524941e-08 7.817 0 0
Packaging Of Telomere Ends R-HSA-171306 2.082511e-08 7.681 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.123171e-08 7.673 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.082511e-08 7.681 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.765085e-08 7.558 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.765085e-08 7.558 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.138121e-08 7.503 0 0
Separation of Sister Chromatids R-HSA-2467813 3.608043e-08 7.443 0 0
Selenoamino acid metabolism R-HSA-2408522 3.608043e-08 7.443 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.346170e-08 7.362 0 0
HDACs deacetylate histones R-HSA-3214815 4.793199e-08 7.319 0 0
Mitotic Prometaphase R-HSA-68877 4.916719e-08 7.308 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.289854e-08 7.201 0 0
Apoptosis R-HSA-109581 6.439110e-08 7.191 1 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.172939e-08 7.144 0 0
Cell junction organization R-HSA-446728 7.818761e-08 7.107 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.753520e-08 7.058 0 0
Meiotic synapsis R-HSA-1221632 9.775388e-08 7.010 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.043542e-07 6.981 0 0
Developmental Biology R-HSA-1266738 1.205463e-07 6.919 1 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.247602e-07 6.904 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.260789e-07 6.899 0 0
Depurination R-HSA-73927 1.271820e-07 6.896 0 0
HATs acetylate histones R-HSA-3214847 1.464489e-07 6.834 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.707336e-07 6.768 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.707336e-07 6.768 0 0
RNA Polymerase I Transcription R-HSA-73864 1.702237e-07 6.769 0 0
Post NMDA receptor activation events R-HSA-438064 1.814453e-07 6.741 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.268156e-07 6.644 0 0
Defective pyroptosis R-HSA-9710421 2.407544e-07 6.618 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.558321e-07 6.592 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.677881e-07 6.572 0 0
Interferon Signaling R-HSA-913531 2.864374e-07 6.543 0 0
Gap junction trafficking R-HSA-190828 3.315233e-07 6.479 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.485814e-07 6.458 0 0
Cleavage of the damaged purine R-HSA-110331 3.755771e-07 6.425 0 0
Gap junction trafficking and regulation R-HSA-157858 4.057094e-07 6.392 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.318192e-07 6.365 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.103591e-07 6.387 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.103591e-07 6.387 0 0
Nucleosome assembly R-HSA-774815 4.528273e-07 6.344 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.528273e-07 6.344 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.876521e-07 6.312 1 1
SARS-CoV-1 Infection R-HSA-9678108 5.481286e-07 6.261 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.075239e-07 6.216 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.804233e-07 6.167 0 0
Depyrimidination R-HSA-73928 6.804233e-07 6.167 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.952453e-07 6.158 0 0
Meiotic recombination R-HSA-912446 7.234765e-07 6.141 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.458199e-07 6.127 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.511319e-07 6.124 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.924842e-07 6.101 0 0
Meiosis R-HSA-1500620 8.347696e-07 6.078 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.487433e-07 6.071 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.332023e-07 6.079 0 0
HCMV Early Events R-HSA-9609690 8.809203e-07 6.055 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.003526e-06 5.998 0 0
Programmed Cell Death R-HSA-5357801 1.484771e-06 5.828 1 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.505241e-06 5.822 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.522680e-06 5.817 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.783052e-06 5.749 0 0
ESR-mediated signaling R-HSA-8939211 1.795699e-06 5.746 0 0
Selective autophagy R-HSA-9663891 1.916073e-06 5.718 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.914760e-06 5.718 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.895268e-06 5.722 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.978767e-06 5.704 0 0
Ub-specific processing proteases R-HSA-5689880 2.111828e-06 5.675 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.129512e-06 5.672 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.233009e-06 5.651 0 0
Gene Silencing by RNA R-HSA-211000 2.278458e-06 5.642 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.285310e-06 5.641 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.454319e-06 5.610 0 0
Signaling by WNT R-HSA-195721 2.912809e-06 5.536 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.971221e-06 5.527 0 0
Interleukin-12 signaling R-HSA-9020591 3.069661e-06 5.513 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.445864e-06 5.463 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.696968e-06 5.432 0 0
DNA Double Strand Break Response R-HSA-5693606 3.793181e-06 5.421 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.870483e-06 5.412 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.073623e-06 5.390 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.379772e-06 5.359 0 0
Membrane Trafficking R-HSA-199991 4.549645e-06 5.342 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.196408e-06 5.284 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.309275e-06 5.275 0 0
Translation R-HSA-72766 5.424260e-06 5.266 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.443686e-06 5.264 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.544023e-06 5.256 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.838731e-06 5.234 0 0
Signaling by ALK in cancer R-HSA-9700206 5.838731e-06 5.234 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.006937e-06 5.154 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.209764e-06 5.142 0 0
Kinesins R-HSA-983189 7.218879e-06 5.142 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.329732e-06 5.135 0 0
Cell-cell junction organization R-HSA-421270 8.434724e-06 5.074 0 0
Amyloid fiber formation R-HSA-977225 8.536689e-06 5.069 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.027663e-05 4.988 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.235470e-05 4.908 0 0
Protein folding R-HSA-391251 1.330471e-05 4.876 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.339503e-05 4.873 1 1
mRNA Splicing - Major Pathway R-HSA-72163 1.389876e-05 4.857 0 0
Adherens junctions interactions R-HSA-418990 1.413133e-05 4.850 0 0
Muscle contraction R-HSA-397014 1.453397e-05 4.838 0 0
Neutrophil degranulation R-HSA-6798695 1.662682e-05 4.779 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.729824e-05 4.762 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.323342e-05 4.634 0 0
Deubiquitination R-HSA-5688426 2.421494e-05 4.616 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.613929e-05 4.583 0 0
Co-inhibition by PD-1 R-HSA-389948 2.743855e-05 4.562 0 0
Metalloprotease DUBs R-HSA-5689901 3.013376e-05 4.521 0 0
Interleukin-12 family signaling R-HSA-447115 3.106258e-05 4.508 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.120570e-05 4.506 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.150358e-05 4.502 0 0
DNA Replication R-HSA-69306 3.150358e-05 4.502 0 0
Gap junction assembly R-HSA-190861 3.294407e-05 4.482 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.296928e-05 4.482 1 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.713763e-05 4.430 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.251284e-05 4.371 0 0
Oncogene Induced Senescence R-HSA-2559585 4.360640e-05 4.360 0 0
Homology Directed Repair R-HSA-5693538 4.384566e-05 4.358 0 0
mRNA Splicing R-HSA-72172 4.705935e-05 4.327 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.248741e-05 4.280 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.279246e-05 4.202 0 0
Neurodegenerative Diseases R-HSA-8863678 6.279246e-05 4.202 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.279246e-05 4.202 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.711554e-05 4.173 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.243424e-05 4.140 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 7.722117e-05 4.112 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.725769e-05 4.112 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.902673e-05 4.102 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.937650e-05 4.100 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.386019e-05 4.076 0 0
MHC class II antigen presentation R-HSA-2132295 8.718307e-05 4.060 0 0
Telomere Maintenance R-HSA-157579 8.833843e-05 4.054 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 9.210794e-05 4.036 0 0
HCMV Infection R-HSA-9609646 9.579940e-05 4.019 0 0
Chaperone Mediated Autophagy R-HSA-9613829 9.664961e-05 4.015 0 0
Ephrin signaling R-HSA-3928664 9.664961e-05 4.015 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.002993e-04 3.999 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.006036e-04 3.997 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.047170e-04 3.980 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.143592e-04 3.942 0 0
Signaling by PTK6 R-HSA-8848021 1.143592e-04 3.942 0 0
Base Excision Repair R-HSA-73884 1.267527e-04 3.897 0 0
Chromosome Maintenance R-HSA-73886 1.465695e-04 3.834 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.588104e-04 3.799 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.613115e-04 3.792 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.613115e-04 3.792 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.951522e-04 3.710 0 0
Nephrin family interactions R-HSA-373753 1.970274e-04 3.705 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.990632e-04 3.701 0 0
DNA Repair R-HSA-73894 1.914138e-04 3.718 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.785884e-04 3.748 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.835408e-04 3.736 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.044499e-04 3.689 0 0
Signaling by RAS mutants R-HSA-6802949 2.436324e-04 3.613 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.436324e-04 3.613 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.436324e-04 3.613 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.436324e-04 3.613 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.572168e-04 3.590 0 0
Cilium Assembly R-HSA-5617833 2.641698e-04 3.578 0 0
Reproduction R-HSA-1474165 2.698376e-04 3.569 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.723375e-04 3.565 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.045701e-04 3.516 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.045701e-04 3.516 0 0
MAPK family signaling cascades R-HSA-5683057 3.354336e-04 3.474 1 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.357105e-04 3.474 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.357105e-04 3.474 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.466384e-04 3.460 0 0
Centrosome maturation R-HSA-380287 3.557237e-04 3.449 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.608434e-04 3.443 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.296858e-04 3.367 0 0
Chromatin modifying enzymes R-HSA-3247509 4.328510e-04 3.364 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.342350e-04 3.362 0 0
Gene expression (Transcription) R-HSA-74160 4.417966e-04 3.355 1 0
EPH-Ephrin signaling R-HSA-2682334 4.594772e-04 3.338 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.659431e-04 3.332 0 0
Signaling by ERBB2 R-HSA-1227986 4.677278e-04 3.330 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.995039e-04 3.301 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.075132e-04 3.295 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.398881e-04 3.268 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.548509e-04 3.256 0 0
Gap junction degradation R-HSA-190873 5.596463e-04 3.252 0 0
Regulation of TP53 Activity R-HSA-5633007 5.662080e-04 3.247 0 0
Hedgehog 'off' state R-HSA-5610787 6.887225e-04 3.162 0 0
Signaling by NOTCH R-HSA-157118 7.086802e-04 3.150 0 0
Regulation of CDH1 Function R-HSA-9764561 7.183014e-04 3.144 0 0
Autophagy R-HSA-9612973 7.222986e-04 3.141 0 0
HIV Infection R-HSA-162906 7.402599e-04 3.131 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.467468e-04 3.127 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 7.467468e-04 3.127 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.787326e-04 3.109 0 0
mRNA 3'-end processing R-HSA-72187 7.787326e-04 3.109 0 0
Chromatin organization R-HSA-4839726 8.418241e-04 3.075 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.786180e-04 3.056 0 0
Host Interactions of HIV factors R-HSA-162909 9.110095e-04 3.040 0 0
Striated Muscle Contraction R-HSA-390522 9.396017e-04 3.027 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 9.396017e-04 3.027 0 0
UCH proteinases R-HSA-5689603 9.854047e-04 3.006 0 0
Macroautophagy R-HSA-1632852 1.006662e-03 2.997 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.131276e-03 2.946 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.161154e-03 2.935 1 0
S Phase R-HSA-69242 1.173945e-03 2.930 0 0
Signaling by Hippo R-HSA-2028269 1.202577e-03 2.920 0 0
SARS-CoV Infections R-HSA-9679506 1.205351e-03 2.919 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.354092e-03 2.868 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.374603e-03 2.862 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.383468e-03 2.859 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.428244e-03 2.845 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.474001e-03 2.832 0 0
HIV Life Cycle R-HSA-162587 1.484218e-03 2.829 0 0
Immune System R-HSA-168256 1.491025e-03 2.827 1 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.500840e-03 2.824 0 0
Ion homeostasis R-HSA-5578775 1.535614e-03 2.814 0 0
Infectious disease R-HSA-5663205 1.560540e-03 2.807 0 0
RNA Polymerase II Transcription R-HSA-73857 1.701108e-03 2.769 1 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.738485e-03 2.760 0 0
mTORC1-mediated signalling R-HSA-166208 1.787867e-03 2.748 0 0
p75NTR signals via NF-kB R-HSA-193639 1.851623e-03 2.732 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.851623e-03 2.732 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.851623e-03 2.732 0 0
Semaphorin interactions R-HSA-373755 1.876754e-03 2.727 0 0
Formation of annular gap junctions R-HSA-196025 1.915146e-03 2.718 0 0
Activation of RAC1 R-HSA-428540 1.991003e-03 2.701 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.201729e-03 2.657 0 0
Protein ubiquitination R-HSA-8852135 1.951956e-03 2.710 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.005641e-03 2.698 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.150113e-03 2.668 0 0
MAP2K and MAPK activation R-HSA-5674135 2.009854e-03 2.697 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.124051e-03 2.673 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.915146e-03 2.718 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.296185e-03 2.639 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.347494e-03 2.629 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.444381e-03 2.612 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.536627e-03 2.596 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.584022e-03 2.588 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.584022e-03 2.588 0 0
Intraflagellar transport R-HSA-5620924 2.601385e-03 2.585 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.658800e-03 2.575 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.806287e-03 2.552 0 0
Negative regulation of MET activity R-HSA-6807004 2.816458e-03 2.550 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.816458e-03 2.550 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.838189e-03 2.547 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.838189e-03 2.547 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.882099e-03 2.540 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.920177e-03 2.535 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.984155e-03 2.525 0 0
Glycolysis R-HSA-70171 2.984155e-03 2.525 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.121654e-03 2.506 0 0
Adaptive Immune System R-HSA-1280218 3.140411e-03 2.503 1 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.163155e-03 2.500 1 0
RAF/MAP kinase cascade R-HSA-5673001 3.191536e-03 2.496 1 0
Oncogenic MAPK signaling R-HSA-6802957 3.235554e-03 2.490 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.550921e-03 2.450 0 0
Activation of BH3-only proteins R-HSA-114452 3.550921e-03 2.450 0 0
Generic Transcription Pathway R-HSA-212436 3.616028e-03 2.442 1 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.628936e-03 2.440 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.628936e-03 2.440 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.700023e-03 2.432 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.055646e-03 2.392 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.138597e-03 2.383 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.138597e-03 2.383 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.138597e-03 2.383 0 0
G1/S Transition R-HSA-69206 4.138597e-03 2.383 0 0
Nef and signal transduction R-HSA-164944 4.165266e-03 2.380 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.176929e-03 2.379 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.311885e-03 2.365 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.338494e-03 2.363 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.374125e-03 2.359 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.423835e-03 2.354 0 0
FLT3 Signaling R-HSA-9607240 4.423835e-03 2.354 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.614625e-03 2.336 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.614625e-03 2.336 0 0
Vesicle-mediated transport R-HSA-5653656 4.805478e-03 2.318 0 0
Signaling by Hedgehog R-HSA-5358351 4.838939e-03 2.315 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.854207e-03 2.314 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.910358e-03 2.309 0 0
Platelet degranulation R-HSA-114608 4.978078e-03 2.303 0 0
G0 and Early G1 R-HSA-1538133 5.258964e-03 2.279 0 0
MTF1 activates gene expression R-HSA-5660489 5.413038e-03 2.267 0 0
Smooth Muscle Contraction R-HSA-445355 5.599976e-03 2.252 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.429621e-03 2.192 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.429621e-03 2.192 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.116693e-03 2.213 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.068388e-03 2.151 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.340920e-03 2.134 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.327133e-03 2.199 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 7.426182e-03 2.129 0 0
Amplification of signal from the kinetochores R-HSA-141424 7.426182e-03 2.129 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.289704e-03 2.201 0 0
Rap1 signalling R-HSA-392517 7.340920e-03 2.134 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.656572e-03 2.177 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.068388e-03 2.151 0 0
Signaling by VEGF R-HSA-194138 7.540474e-03 2.123 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.558363e-03 2.122 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.558363e-03 2.122 0 0
IRE1alpha activates chaperones R-HSA-381070 7.907494e-03 2.102 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.043744e-03 2.095 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.043744e-03 2.095 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 8.149807e-03 2.089 0 0
HCMV Late Events R-HSA-9610379 8.158918e-03 2.088 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.266581e-03 2.083 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.266581e-03 2.083 0 0
RMTs methylate histone arginines R-HSA-3214858 8.327366e-03 2.079 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.333082e-03 2.079 0 0
NF-kB is activated and signals survival R-HSA-209560 8.416806e-03 2.075 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.416806e-03 2.075 0 0
Signaling by EGFR R-HSA-177929 8.451041e-03 2.073 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.451041e-03 2.073 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.693766e-03 2.061 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.705686e-03 2.060 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.849119e-03 2.053 0 0
Deadenylation of mRNA R-HSA-429947 8.849119e-03 2.053 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 8.849119e-03 2.053 0 0
Nuclear import of Rev protein R-HSA-180746 8.968474e-03 2.047 0 0
Negative regulation of FLT3 R-HSA-9706369 9.191535e-03 2.037 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.410155e-03 2.026 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.410155e-03 2.026 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 9.441435e-03 2.025 0 0
Adrenoceptors R-HSA-390696 9.441435e-03 2.025 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 9.441435e-03 2.025 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.623096e-03 2.017 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.035496e-02 1.985 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.057364e-02 1.976 0 0
Long-term potentiation R-HSA-9620244 1.076933e-02 1.968 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.095035e-02 1.961 0 0
Glucose metabolism R-HSA-70326 1.107241e-02 1.956 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.127932e-02 1.948 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.127932e-02 1.948 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.127932e-02 1.948 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.144311e-02 1.941 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.144311e-02 1.941 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.144311e-02 1.941 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.144311e-02 1.941 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.144311e-02 1.941 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.144311e-02 1.941 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.144311e-02 1.941 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.144311e-02 1.941 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.144311e-02 1.941 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.144311e-02 1.941 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.144311e-02 1.941 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.145564e-02 1.941 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.209224e-02 1.917 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.239024e-02 1.907 0 0
FLT3 signaling in disease R-HSA-9682385 1.239024e-02 1.907 0 0
PCP/CE pathway R-HSA-4086400 1.240380e-02 1.906 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.286027e-02 1.891 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.298617e-02 1.887 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.330475e-02 1.876 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.330475e-02 1.876 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.330475e-02 1.876 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.359773e-02 1.867 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.405573e-02 1.852 0 0
Maturation of protein E R-HSA-9694493 1.431909e-02 1.844 0 0
Maturation of protein E R-HSA-9683683 1.431909e-02 1.844 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.453679e-02 1.838 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.476840e-02 1.831 0 0
Signaling by FGFR2 R-HSA-5654738 1.525447e-02 1.817 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.552491e-02 1.809 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.635814e-02 1.786 0 0
DNA Damage Bypass R-HSA-73893 1.653527e-02 1.782 0 0
FGFR2 alternative splicing R-HSA-6803529 1.706097e-02 1.768 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.166652e-02 1.664 0 0
Late endosomal microautophagy R-HSA-9615710 2.166652e-02 1.664 0 0
RAF activation R-HSA-5673000 2.212689e-02 1.655 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.173773e-02 1.663 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.706097e-02 1.768 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.212689e-02 1.655 0 0
Platelet calcium homeostasis R-HSA-418360 2.166652e-02 1.664 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.099645e-02 1.678 0 0
Cyclin D associated events in G1 R-HSA-69231 1.912310e-02 1.718 0 0
G1 Phase R-HSA-69236 1.912310e-02 1.718 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.675063e-02 1.776 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.894385e-02 1.723 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.894385e-02 1.723 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.672372e-02 1.777 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.074053e-02 1.683 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.209967e-02 1.656 0 0
Polo-like kinase mediated events R-HSA-156711 1.833369e-02 1.737 0 0
Josephin domain DUBs R-HSA-5689877 1.811266e-02 1.742 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.833369e-02 1.737 0 0
Ion transport by P-type ATPases R-HSA-936837 2.180757e-02 1.661 0 0
Disease R-HSA-1643685 1.969488e-02 1.706 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.209967e-02 1.656 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.818567e-02 1.740 0 0
Pexophagy R-HSA-9664873 1.811266e-02 1.742 0 0
Translesion Synthesis by POLH R-HSA-110320 2.244697e-02 1.649 0 0
The NLRP3 inflammasome R-HSA-844456 2.244697e-02 1.649 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.246819e-02 1.648 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.260509e-02 1.646 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.260509e-02 1.646 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.260509e-02 1.646 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.260509e-02 1.646 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.260509e-02 1.646 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.260509e-02 1.646 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.383766e-02 1.623 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.385975e-02 1.622 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.385975e-02 1.622 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.385975e-02 1.622 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.388462e-02 1.622 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.394486e-02 1.621 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.460777e-02 1.609 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.460777e-02 1.609 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.460777e-02 1.609 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.531644e-02 1.597 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.531644e-02 1.597 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.532464e-02 1.596 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.623871e-02 1.581 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.666243e-02 1.574 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.774605e-02 1.557 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.774605e-02 1.557 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.791421e-02 1.554 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.864400e-02 1.543 0 0
Hemostasis R-HSA-109582 2.874903e-02 1.541 1 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.875837e-02 1.541 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.881025e-02 1.540 0 0
G1/S-Specific Transcription R-HSA-69205 2.924425e-02 1.534 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.930719e-02 1.533 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.930719e-02 1.533 0 0
Recycling of eIF2:GDP R-HSA-72731 2.930719e-02 1.533 0 0
Regulation of PTEN localization R-HSA-8948747 2.930719e-02 1.533 0 0
EGFR downregulation R-HSA-182971 2.938180e-02 1.532 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.938180e-02 1.532 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.938180e-02 1.532 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.938180e-02 1.532 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.956350e-02 1.529 0 0
Signaling by NOTCH4 R-HSA-9013694 3.067321e-02 1.513 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.086595e-02 1.511 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.086595e-02 1.511 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.086595e-02 1.511 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.140258e-02 1.503 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.223968e-02 1.492 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.239127e-02 1.490 0 0
MTOR signalling R-HSA-165159 3.239127e-02 1.490 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.239127e-02 1.490 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.239127e-02 1.490 0 0
Basigin interactions R-HSA-210991 3.249743e-02 1.488 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.266573e-02 1.486 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.269199e-02 1.486 0 0
Signaling by NOTCH3 R-HSA-9012852 3.316255e-02 1.479 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.335246e-02 1.477 0 0
Degradation of DVL R-HSA-4641258 3.335246e-02 1.477 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.362821e-02 1.473 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.362821e-02 1.473 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.373568e-02 1.472 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.388277e-02 1.470 0 0
tRNA processing in the nucleus R-HSA-6784531 3.471961e-02 1.459 0 0
Platelet homeostasis R-HSA-418346 3.533438e-02 1.452 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.609486e-02 1.443 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.609486e-02 1.443 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.609486e-02 1.443 0 0
Signaling by SCF-KIT R-HSA-1433557 3.647349e-02 1.438 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.680849e-02 1.434 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.680849e-02 1.434 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.828206e-02 1.417 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.828206e-02 1.417 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.849619e-02 1.415 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.849619e-02 1.415 0 0
Assembly Of The HIV Virion R-HSA-175474 3.849619e-02 1.415 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.868359e-02 1.412 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.883773e-02 1.411 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.883773e-02 1.411 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.889104e-02 1.410 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.892436e-02 1.410 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 3.892436e-02 1.410 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.892436e-02 1.410 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 3.892436e-02 1.410 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 3.892436e-02 1.410 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.918870e-02 1.407 0 0
Type I hemidesmosome assembly R-HSA-446107 3.931196e-02 1.405 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.931196e-02 1.405 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.931196e-02 1.405 0 0
Stabilization of p53 R-HSA-69541 4.274561e-02 1.369 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.426308e-02 1.354 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.517738e-02 1.345 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.520840e-02 1.345 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.569177e-02 1.340 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.569177e-02 1.340 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.569177e-02 1.340 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.569177e-02 1.340 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 4.720836e-02 1.326 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.720836e-02 1.326 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.780201e-02 1.321 0 0
IRS activation R-HSA-74713 4.780201e-02 1.321 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.780201e-02 1.321 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.103210e-02 1.292 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.103210e-02 1.292 0 0
Signal attenuation R-HSA-74749 6.445316e-02 1.191 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.445316e-02 1.191 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.856418e-02 1.232 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.856418e-02 1.232 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.016051e-02 1.154 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.016051e-02 1.154 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.016051e-02 1.154 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.175832e-02 1.286 0 0
Regulation of signaling by CBL R-HSA-912631 6.092768e-02 1.215 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.099905e-02 1.149 0 0
Dual Incision in GG-NER R-HSA-5696400 5.017307e-02 1.300 0 0
Trafficking of AMPA receptors R-HSA-399719 6.677259e-02 1.175 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.805748e-02 1.318 0 0
RET signaling R-HSA-8853659 6.349223e-02 1.197 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.996726e-02 1.222 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.996726e-02 1.222 0 0
HIV Transcription Initiation R-HSA-167161 5.996726e-02 1.222 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.996726e-02 1.222 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.787187e-02 1.320 0 0
Orc1 removal from chromatin R-HSA-68949 4.787187e-02 1.320 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.787187e-02 1.320 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.285606e-02 1.277 0 0
Metabolism of non-coding RNA R-HSA-194441 4.944094e-02 1.306 0 0
snRNP Assembly R-HSA-191859 4.944094e-02 1.306 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 6.385011e-02 1.195 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.987209e-02 1.156 0 0
Nucleotide Excision Repair R-HSA-5696398 5.454605e-02 1.263 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.379490e-02 1.269 0 0
Platelet sensitization by LDL R-HSA-432142 5.175832e-02 1.286 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 5.175832e-02 1.286 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.379490e-02 1.269 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.780201e-02 1.321 0 0
Translesion synthesis by REV1 R-HSA-110312 7.016051e-02 1.154 0 0
Regulation of Apoptosis R-HSA-169911 5.657962e-02 1.247 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.996726e-02 1.222 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.996726e-02 1.222 0 0
Synthesis of DNA R-HSA-69239 6.235161e-02 1.205 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.564764e-02 1.255 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 6.349223e-02 1.197 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.805748e-02 1.318 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.805748e-02 1.318 0 0
Degradation of CDH1 R-HSA-9766229 6.862224e-02 1.164 0 0
Protein methylation R-HSA-8876725 7.016051e-02 1.154 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.379490e-02 1.269 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.091788e-02 1.149 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 6.862224e-02 1.164 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 6.862224e-02 1.164 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.017307e-02 1.300 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.947696e-02 1.158 0 0
Cardiac conduction R-HSA-5576891 5.809835e-02 1.236 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.103210e-02 1.292 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.424370e-02 1.266 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.017307e-02 1.300 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.817994e-02 1.235 0 0
Signaling by Leptin R-HSA-2586552 6.445316e-02 1.191 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.445316e-02 1.191 0 0
Signaling by FGFR R-HSA-190236 5.132029e-02 1.290 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.092768e-02 1.215 0 0
Glycogen metabolism R-HSA-8982491 4.805748e-02 1.318 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.016051e-02 1.154 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.364518e-02 1.133 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.364518e-02 1.133 0 0
Signaling by FGFR4 R-HSA-5654743 7.364518e-02 1.133 0 0
TCR signaling R-HSA-202403 7.545612e-02 1.122 1 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 7.647634e-02 1.116 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.658459e-02 1.116 0 0
Regulation of TP53 Expression R-HSA-6804754 7.795714e-02 1.108 0 0
Diseases of cellular response to stress R-HSA-9675132 7.795714e-02 1.108 0 0
Diseases of Cellular Senescence R-HSA-9630747 7.795714e-02 1.108 0 0
Regulation of cortical dendrite branching R-HSA-8985801 7.795714e-02 1.108 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.795714e-02 1.108 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.902256e-02 1.102 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.902256e-02 1.102 0 0
PECAM1 interactions R-HSA-210990 7.952921e-02 1.099 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.116018e-02 1.091 0 0
Sensory processing of sound R-HSA-9659379 8.179812e-02 1.087 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 8.196932e-02 1.086 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.196932e-02 1.086 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 8.196932e-02 1.086 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.244630e-02 1.084 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.292542e-02 1.081 0 0
Translesion synthesis by POLI R-HSA-5656121 8.292542e-02 1.081 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.292542e-02 1.081 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 8.292542e-02 1.081 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.292542e-02 1.081 0 0
Cellular response to hypoxia R-HSA-1234174 8.297442e-02 1.081 0 0
Dual incision in TC-NER R-HSA-6782135 8.298769e-02 1.081 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.415234e-02 1.075 0 0
Integrin signaling R-HSA-354192 8.415234e-02 1.075 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.415234e-02 1.075 0 0
Erythropoietin activates STAT5 R-HSA-9027283 8.628472e-02 1.064 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 8.628472e-02 1.064 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.732312e-02 1.059 0 0
Signaling by MET R-HSA-6806834 8.784193e-02 1.056 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.809880e-02 1.055 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.912891e-02 1.050 0 0
Signaling by FGFR3 R-HSA-5654741 8.912891e-02 1.050 0 0
Metabolism of proteins R-HSA-392499 8.932446e-02 1.049 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.996117e-02 1.046 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 9.008648e-02 1.045 0 0
Circadian clock R-HSA-9909396 9.321891e-02 1.030 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.374903e-02 1.028 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.374903e-02 1.028 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.382710e-02 1.028 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.382710e-02 1.028 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.382710e-02 1.028 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 9.618732e-02 1.017 0 0
Signaling by GSK3beta mutants R-HSA-5339716 9.618732e-02 1.017 0 0
Integration of provirus R-HSA-162592 9.618732e-02 1.017 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 9.618732e-02 1.017 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 9.618732e-02 1.017 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.630356e-02 1.016 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 9.673736e-02 1.014 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.682948e-02 1.014 0 0
Translesion synthesis by POLK R-HSA-5655862 9.682948e-02 1.014 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.682948e-02 1.014 0 0
Cellular response to chemical stress R-HSA-9711123 9.787056e-02 1.009 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.002746e-01 0.999 0 0
Inflammasomes R-HSA-622312 1.002746e-01 0.999 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.039443e-01 0.983 0 0
Signaling by NOTCH2 R-HSA-1980145 1.039443e-01 0.983 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.039443e-01 0.983 0 0
Transcription of the HIV genome R-HSA-167172 1.041116e-01 0.983 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.057987e-01 0.976 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.057987e-01 0.976 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.064247e-01 0.973 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.065532e-01 0.972 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 1.083688e-01 0.965 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.083688e-01 0.965 0 0
Defective OGG1 Localization R-HSA-9657050 1.083688e-01 0.965 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.083688e-01 0.965 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.083688e-01 0.965 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.083688e-01 0.965 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.083688e-01 0.965 0 0
SOS-mediated signalling R-HSA-112412 1.091703e-01 0.962 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.091703e-01 0.962 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.091703e-01 0.962 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.091703e-01 0.962 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.091703e-01 0.962 0 0
Signaling by Interleukins R-HSA-449147 1.102274e-01 0.958 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.118307e-01 0.951 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.118307e-01 0.951 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.118307e-01 0.951 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.118307e-01 0.951 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.118307e-01 0.951 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.119603e-01 0.951 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.119603e-01 0.951 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.132319e-01 0.946 0 0
Axonal growth stimulation R-HSA-209563 1.132319e-01 0.946 0 0
MET interacts with TNS proteins R-HSA-8875513 1.132319e-01 0.946 0 0
MET activates PTPN11 R-HSA-8865999 1.132319e-01 0.946 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.132319e-01 0.946 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.132319e-01 0.946 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.135520e-01 0.945 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.143323e-01 0.942 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.143323e-01 0.942 0 0
Polymerase switching R-HSA-69091 1.143323e-01 0.942 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.143323e-01 0.942 0 0
Leading Strand Synthesis R-HSA-69109 1.143323e-01 0.942 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.143323e-01 0.942 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.143323e-01 0.942 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.143323e-01 0.942 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.143323e-01 0.942 0 0
Repression of WNT target genes R-HSA-4641265 1.143323e-01 0.942 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.143323e-01 0.942 0 0
Signaling by LTK R-HSA-9842663 1.143323e-01 0.942 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.143323e-01 0.942 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.147294e-01 0.940 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.147294e-01 0.940 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.147294e-01 0.940 0 0
PERK regulates gene expression R-HSA-381042 1.147294e-01 0.940 0 0
Co-stimulation by CD28 R-HSA-389356 1.157455e-01 0.936 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.049995e-01 0.688 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 2.049995e-01 0.688 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.049995e-01 0.688 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.049995e-01 0.688 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.049995e-01 0.688 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 2.049995e-01 0.688 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.049995e-01 0.688 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.049995e-01 0.688 0 0
Defective GALM causes GALAC4 R-HSA-9931929 2.049995e-01 0.688 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.049995e-01 0.688 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.049995e-01 0.688 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.049995e-01 0.688 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.049995e-01 0.688 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.049995e-01 0.688 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.049995e-01 0.688 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.516918e-01 0.819 0 0
Regulation of gap junction activity R-HSA-191650 1.516918e-01 0.819 0 0
NADE modulates death signalling R-HSA-205025 1.516918e-01 0.819 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.516918e-01 0.819 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.516918e-01 0.819 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.516918e-01 0.819 0 0
Co-inhibition by BTLA R-HSA-9927353 1.922331e-01 0.716 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.922331e-01 0.716 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.922331e-01 0.716 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.922331e-01 0.716 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.341013e-01 0.873 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.341013e-01 0.873 0 0
ALK mutants bind TKIs R-HSA-9700645 1.607701e-01 0.794 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.339535e-01 0.631 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.339535e-01 0.631 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.888681e-01 0.724 0 0
2-LTR circle formation R-HSA-164843 1.888681e-01 0.724 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.888681e-01 0.724 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.546173e-01 0.811 0 0
Removal of the Flap Intermediate R-HSA-69166 1.546173e-01 0.811 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.278761e-01 0.893 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.180939e-01 0.661 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.180939e-01 0.661 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.180939e-01 0.661 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.180939e-01 0.661 0 0
Erythropoietin activates RAS R-HSA-9027284 1.764948e-01 0.753 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.764948e-01 0.753 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.449032e-01 0.839 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.449032e-01 0.839 0 0
Phosphorylation of the APC/C R-HSA-176412 1.993416e-01 0.700 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.243303e-01 0.905 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 1.496432e-01 0.825 0 0
Tight junction interactions R-HSA-420029 1.496432e-01 0.825 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.655139e-01 0.781 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.820604e-01 0.740 0 0
Signaling by Erythropoietin R-HSA-9006335 2.169668e-01 0.664 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.955323e-01 0.709 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.730674e-01 0.762 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.909253e-01 0.719 0 0
GPER1 signaling R-HSA-9634597 1.990575e-01 0.701 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.385518e-01 0.858 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.983326e-01 0.703 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.816135e-01 0.741 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.191303e-01 0.924 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.458411e-01 0.836 0 0
Formation of definitive endoderm R-HSA-9823730 1.628413e-01 0.788 0 0
FOXO-mediated transcription R-HSA-9614085 1.374521e-01 0.862 0 0
Downstream TCR signaling R-HSA-202424 1.723758e-01 0.764 1 1
Regulation of CDH11 function R-HSA-9762292 1.888681e-01 0.724 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.374521e-01 0.862 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.510306e-01 0.821 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.606963e-01 0.794 0 0
Activation of the pre-replicative complex R-HSA-68962 2.352126e-01 0.629 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.993416e-01 0.700 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.764948e-01 0.753 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.487677e-01 0.827 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.213293e-01 0.655 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.888681e-01 0.724 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.307835e-01 0.637 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.992300e-01 0.701 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.516918e-01 0.819 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.281906e-01 0.892 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.281906e-01 0.892 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.313332e-01 0.636 0 0
Mismatch Repair R-HSA-5358508 1.278761e-01 0.893 0 0
Dopamine receptors R-HSA-390651 1.516918e-01 0.819 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 1.496432e-01 0.825 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.230127e-01 0.652 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.201485e-01 0.657 0 0
Interleukin-2 signaling R-HSA-9020558 2.180939e-01 0.661 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.198407e-01 0.921 0 0
Signal transduction by L1 R-HSA-445144 1.628413e-01 0.788 0 0
Developmental Cell Lineages R-HSA-9734767 1.429761e-01 0.845 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.255073e-01 0.901 0 0
Signaling by TGFB family members R-HSA-9006936 1.304639e-01 0.885 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.339535e-01 0.631 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.801504e-01 0.744 1 1
Degradation of CRY and PER proteins R-HSA-9932298 2.053301e-01 0.688 0 0
Ca2+ pathway R-HSA-4086398 1.458411e-01 0.836 0 0
Regulation of KIT signaling R-HSA-1433559 1.546173e-01 0.811 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.642884e-01 0.784 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.642884e-01 0.784 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.642884e-01 0.784 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.642884e-01 0.784 0 0
G alpha (z) signalling events R-HSA-418597 1.927707e-01 0.715 1 1
Mitophagy R-HSA-5205647 1.955323e-01 0.709 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 1.449032e-01 0.839 0 0
GPVI-mediated activation cascade R-HSA-114604 2.277455e-01 0.643 0 0
Interleukin-1 signaling R-HSA-9020702 1.528923e-01 0.816 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.922331e-01 0.716 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.955323e-01 0.709 0 0
Ca-dependent events R-HSA-111996 2.201485e-01 0.657 0 0
Regulation of pyruvate metabolism R-HSA-9861718 1.730674e-01 0.762 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.373625e-01 0.862 0 0
Signaling by NOTCH1 R-HSA-1980143 1.746049e-01 0.758 0 0
DAG and IP3 signaling R-HSA-1489509 1.606963e-01 0.794 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.653044e-01 0.782 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.653044e-01 0.782 0 0
Calmodulin induced events R-HSA-111933 2.277455e-01 0.643 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.049995e-01 0.688 0 0
Inhibition of PKR R-HSA-169131 2.049995e-01 0.688 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.339535e-01 0.631 0 0
Signaling by APC mutants R-HSA-4839744 2.180939e-01 0.661 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.764948e-01 0.753 0 0
Protein hydroxylation R-HSA-9629569 1.628413e-01 0.788 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.993416e-01 0.700 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.230127e-01 0.652 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.011380e-01 0.697 0 0
Degradation of AXIN R-HSA-4641257 1.380167e-01 0.860 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.380167e-01 0.860 0 0
CaM pathway R-HSA-111997 2.277455e-01 0.643 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.934612e-01 0.713 0 0
Opioid Signalling R-HSA-111885 1.777350e-01 0.750 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.934612e-01 0.713 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.934612e-01 0.713 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.195131e-01 0.923 0 0
PTEN Regulation R-HSA-6807070 1.379034e-01 0.860 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.642884e-01 0.784 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.764948e-01 0.753 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.230127e-01 0.652 0 0
Signaling by FGFR1 R-HSA-5654736 1.240293e-01 0.906 0 0
Hedgehog 'on' state R-HSA-5632684 1.281906e-01 0.892 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.653044e-01 0.782 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.653044e-01 0.782 0 0
Pyruvate metabolism R-HSA-70268 2.191865e-01 0.659 0 0
Gluconeogenesis R-HSA-70263 1.990575e-01 0.701 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.341013e-01 0.873 0 0
ABC transporter disorders R-HSA-5619084 1.952157e-01 0.709 0 0
ABC-family proteins mediated transport R-HSA-382556 2.124899e-01 0.673 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.011380e-01 0.697 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.352126e-01 0.629 0 0
Signaling by NTRKs R-HSA-166520 1.520729e-01 0.818 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.607701e-01 0.794 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.339535e-01 0.631 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.230127e-01 0.652 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.606963e-01 0.794 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.126326e-01 0.672 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.338511e-01 0.873 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.820604e-01 0.740 0 0
Hedgehog ligand biogenesis R-HSA-5358346 1.463203e-01 0.835 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 2.053005e-01 0.688 0 0
Diseases of Base Excision Repair R-HSA-9605308 2.339535e-01 0.631 0 0
Signaling by ALK R-HSA-201556 1.634754e-01 0.787 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.339535e-01 0.631 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.546173e-01 0.811 0 0
Glucagon-type ligand receptors R-HSA-420092 2.169668e-01 0.664 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.909253e-01 0.719 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.339535e-01 0.631 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 1.628413e-01 0.788 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.816135e-01 0.741 0 0
Glycogen synthesis R-HSA-3322077 1.628413e-01 0.788 0 0
Response to metal ions R-HSA-5660526 2.230127e-01 0.652 0 0
Regulation of BACH1 activity R-HSA-9708530 1.993416e-01 0.700 0 0
Interleukin-37 signaling R-HSA-9008059 2.352126e-01 0.629 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.353488e-01 0.628 0 0
Signaling by ERBB4 R-HSA-1236394 2.375613e-01 0.624 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.408220e-01 0.618 0 0
Interleukin-1 family signaling R-HSA-446652 2.409130e-01 0.618 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.421000e-01 0.616 0 0
Transmission across Chemical Synapses R-HSA-112315 2.468650e-01 0.608 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.473633e-01 0.607 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.473633e-01 0.607 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.473633e-01 0.607 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.473633e-01 0.607 0 0
Glycogen storage diseases R-HSA-3229121 2.473633e-01 0.607 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.481599e-01 0.605 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.481599e-01 0.605 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.481599e-01 0.605 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.481599e-01 0.605 0 0
Signaling by AXIN mutants R-HSA-4839735 2.481599e-01 0.605 0 0
Amine ligand-binding receptors R-HSA-375280 2.508979e-01 0.601 0 0
Netrin-1 signaling R-HSA-373752 2.508979e-01 0.601 1 1
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.526564e-01 0.597 0 0
Budding and maturation of HIV virion R-HSA-162588 2.539074e-01 0.595 0 0
Downstream signal transduction R-HSA-186763 2.539074e-01 0.595 0 0
Regulated Necrosis R-HSA-5218859 2.606982e-01 0.584 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.616094e-01 0.582 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.667620e-01 0.574 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.702231e-01 0.568 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.722502e-01 0.565 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.722502e-01 0.565 0 0
PLC beta mediated events R-HSA-112043 2.725070e-01 0.565 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.725070e-01 0.565 0 0
DNA strand elongation R-HSA-69190 2.729905e-01 0.564 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.739412e-01 0.562 0 0
Post-translational protein phosphorylation R-HSA-8957275 2.746868e-01 0.561 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.761220e-01 0.559 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.761220e-01 0.559 0 0
STAT5 Activation R-HSA-9645135 2.761220e-01 0.559 0 0
G2/M DNA replication checkpoint R-HSA-69478 2.761220e-01 0.559 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.761220e-01 0.559 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.761220e-01 0.559 0 0
Lipid particle organization R-HSA-8964572 2.761220e-01 0.559 0 0
MET activates RAS signaling R-HSA-8851805 2.787964e-01 0.555 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.787964e-01 0.555 0 0
Interleukin-15 signaling R-HSA-8983432 2.787964e-01 0.555 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 2.787964e-01 0.555 0 0
RAS processing R-HSA-9648002 2.790499e-01 0.554 1 1
Plasma lipoprotein clearance R-HSA-8964043 2.790499e-01 0.554 0 0
Diseases of DNA repair R-HSA-9675135 2.829061e-01 0.548 0 0
Ion channel transport R-HSA-983712 2.849963e-01 0.545 0 0
Interleukin-7 signaling R-HSA-1266695 2.850254e-01 0.545 0 0
TGFBR3 expression R-HSA-9839394 2.850254e-01 0.545 0 0
Mitochondrial protein import R-HSA-1268020 2.867089e-01 0.543 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.911628e-01 0.536 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.911628e-01 0.536 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.911628e-01 0.536 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 2.911628e-01 0.536 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.911628e-01 0.536 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.911628e-01 0.536 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.911628e-01 0.536 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.911628e-01 0.536 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.911628e-01 0.536 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.911628e-01 0.536 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.911628e-01 0.536 0 0
Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 R-HSA-9916720 2.911628e-01 0.536 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.911628e-01 0.536 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 2.911628e-01 0.536 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.911628e-01 0.536 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.911628e-01 0.536 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.911628e-01 0.536 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.911628e-01 0.536 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.911628e-01 0.536 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.911628e-01 0.536 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.911628e-01 0.536 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.911628e-01 0.536 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.911628e-01 0.536 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.911628e-01 0.536 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.911628e-01 0.536 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.911628e-01 0.536 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.911843e-01 0.536 0 0
Nuclear RNA decay R-HSA-9930044 2.924006e-01 0.534 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.967691e-01 0.528 0 0
Post-translational protein modification R-HSA-597592 2.996731e-01 0.523 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.070043e-01 0.513 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.070043e-01 0.513 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 3.070043e-01 0.513 0 0
Myogenesis R-HSA-525793 3.070043e-01 0.513 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.070462e-01 0.513 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.097546e-01 0.509 0 0
Formation of axial mesoderm R-HSA-9796292 3.097546e-01 0.509 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.097546e-01 0.509 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.097546e-01 0.509 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 3.097546e-01 0.509 0 0
Interleukin-6 signaling R-HSA-1059683 3.097546e-01 0.509 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 3.097546e-01 0.509 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 3.097546e-01 0.509 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.097546e-01 0.509 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.099197e-01 0.509 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.120768e-01 0.506 0 0
Innate Immune System R-HSA-168249 3.142385e-01 0.503 1 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.148171e-01 0.502 0 0
Metal ion SLC transporters R-HSA-425410 3.158930e-01 0.500 0 0
Interferon alpha/beta signaling R-HSA-909733 3.159865e-01 0.500 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.181518e-01 0.497 0 0
Disinhibition of SNARE formation R-HSA-114516 3.181518e-01 0.497 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.181518e-01 0.497 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.181518e-01 0.497 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.181518e-01 0.497 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.182686e-01 0.497 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.190115e-01 0.496 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.230842e-01 0.491 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.230842e-01 0.491 0 0
Protein localization R-HSA-9609507 3.233490e-01 0.490 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.292131e-01 0.483 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 3.292131e-01 0.483 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.292131e-01 0.483 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.292131e-01 0.483 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.292131e-01 0.483 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 3.292131e-01 0.483 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.319586e-01 0.479 0 0
Calnexin/calreticulin cycle R-HSA-901042 3.319586e-01 0.479 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.328612e-01 0.478 0 0
Translation of Structural Proteins R-HSA-9683701 3.328612e-01 0.478 0 0
Retrograde neurotrophin signalling R-HSA-177504 3.408084e-01 0.467 0 0
Malate-aspartate shuttle R-HSA-9856872 3.408084e-01 0.467 0 0
Zinc transporters R-HSA-435354 3.408084e-01 0.467 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.452922e-01 0.462 0 0
Lagging Strand Synthesis R-HSA-69186 3.487719e-01 0.457 0 0
G-protein activation R-HSA-202040 3.487719e-01 0.457 0 0
Signalling to RAS R-HSA-167044 3.487719e-01 0.457 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.487719e-01 0.457 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.515690e-01 0.454 0 0
Signalling to ERKs R-HSA-187687 3.519870e-01 0.453 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.543777e-01 0.451 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.558633e-01 0.449 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.595779e-01 0.444 0 0
Sodium/Proton exchangers R-HSA-425986 3.595779e-01 0.444 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.595779e-01 0.444 0 0
Interleukin-9 signaling R-HSA-8985947 3.595779e-01 0.444 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.595779e-01 0.444 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.595779e-01 0.444 0 0
G-protein mediated events R-HSA-112040 3.602451e-01 0.443 0 0
Regulation of beta-cell development R-HSA-186712 3.634620e-01 0.440 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.641110e-01 0.439 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.679922e-01 0.434 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.679922e-01 0.434 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.679922e-01 0.434 0 0
Potassium transport channels R-HSA-1296067 3.679922e-01 0.434 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.679922e-01 0.434 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.679922e-01 0.434 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 3.679922e-01 0.434 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.679922e-01 0.434 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 3.679922e-01 0.434 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.679922e-01 0.434 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.679922e-01 0.434 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.679922e-01 0.434 0 0
Signalling to ERK5 R-HSA-198765 3.679922e-01 0.434 0 0
C6 deamination of adenosine R-HSA-75102 3.679922e-01 0.434 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 3.679922e-01 0.434 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.679922e-01 0.434 0 0
SHC1 events in EGFR signaling R-HSA-180336 3.717546e-01 0.430 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.717546e-01 0.430 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.717546e-01 0.430 0 0
p38MAPK events R-HSA-171007 3.717546e-01 0.430 0 0
DCC mediated attractive signaling R-HSA-418885 3.717546e-01 0.430 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.718137e-01 0.430 0 0
RUNX2 regulates bone development R-HSA-8941326 3.721043e-01 0.429 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.721043e-01 0.429 0 0
Regulation of insulin secretion R-HSA-422356 3.722199e-01 0.429 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.739929e-01 0.427 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.739929e-01 0.427 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.739929e-01 0.427 0 0
Mitochondrial calcium ion transport R-HSA-8949215 3.744795e-01 0.427 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.744795e-01 0.427 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.836689e-01 0.416 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.964092e-01 0.402 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.991899e-01 0.399 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.991899e-01 0.399 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.000377e-01 0.398 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.000377e-01 0.398 0 0
Lipophagy R-HSA-9613354 4.000377e-01 0.398 0 0
Interleukin-21 signaling R-HSA-9020958 4.000377e-01 0.398 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.000377e-01 0.398 0 0
WNT mediated activation of DVL R-HSA-201688 4.000377e-01 0.398 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 4.000377e-01 0.398 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 4.000377e-01 0.398 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.000377e-01 0.398 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.000377e-01 0.398 0 0
Unwinding of DNA R-HSA-176974 4.000377e-01 0.398 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.000377e-01 0.398 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.000377e-01 0.398 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.000377e-01 0.398 0 0
ARMS-mediated activation R-HSA-170984 4.000377e-01 0.398 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.000377e-01 0.398 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.000377e-01 0.398 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.000377e-01 0.398 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.000377e-01 0.398 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.000377e-01 0.398 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.000971e-01 0.398 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.024133e-01 0.395 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.024133e-01 0.395 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.064137e-01 0.391 0 0
Death Receptor Signaling R-HSA-73887 4.166507e-01 0.380 0 0
Adipogenesis R-HSA-9843745 4.225118e-01 0.374 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.248385e-01 0.372 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.248385e-01 0.372 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.255238e-01 0.371 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.255238e-01 0.371 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.255238e-01 0.371 0 0
Growth hormone receptor signaling R-HSA-982772 4.255238e-01 0.371 0 0
Syndecan interactions R-HSA-3000170 4.255238e-01 0.371 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.324455e-01 0.364 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.326274e-01 0.364 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.326274e-01 0.364 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 4.326274e-01 0.364 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.326274e-01 0.364 0 0
Galactose catabolism R-HSA-70370 4.326274e-01 0.364 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.364982e-01 0.360 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.364982e-01 0.360 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.364982e-01 0.360 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.364982e-01 0.360 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.364982e-01 0.360 0 0
Invadopodia formation R-HSA-8941237 4.364982e-01 0.360 0 0
MET activates STAT3 R-HSA-8875791 4.364982e-01 0.360 0 0
Intracellular oxygen transport R-HSA-8981607 4.364982e-01 0.360 0 0
Histamine receptors R-HSA-390650 4.364982e-01 0.360 0 0
Binding and entry of HIV virion R-HSA-173107 4.392542e-01 0.357 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.392542e-01 0.357 0 0
PI3K/AKT activation R-HSA-198203 4.392542e-01 0.357 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.392542e-01 0.357 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.392542e-01 0.357 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.392542e-01 0.357 0 0
Signaling by WNT in cancer R-HSA-4791275 4.409389e-01 0.356 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.431984e-01 0.353 0 0
ER-Phagosome pathway R-HSA-1236974 4.495077e-01 0.347 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.506677e-01 0.346 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.506677e-01 0.346 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.506677e-01 0.346 0 0
NRAGE signals death through JNK R-HSA-193648 4.520215e-01 0.345 0 0
TNF signaling R-HSA-75893 4.520215e-01 0.345 0 0
Diseases of Immune System R-HSA-5260271 4.523863e-01 0.344 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.523863e-01 0.344 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.581189e-01 0.339 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.581189e-01 0.339 0 0
NGF-stimulated transcription R-HSA-9031628 4.614565e-01 0.336 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.622616e-01 0.335 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.629239e-01 0.334 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.629239e-01 0.334 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.629239e-01 0.334 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.629239e-01 0.334 0 0
Potential therapeutics for SARS R-HSA-9679191 4.640585e-01 0.333 0 0
Neuronal System R-HSA-112316 4.692863e-01 0.329 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.721630e-01 0.326 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.770216e-01 0.321 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.770216e-01 0.321 0 0
vRNP Assembly R-HSA-192905 4.770216e-01 0.321 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.770216e-01 0.321 0 0
Suppression of apoptosis R-HSA-9635465 4.770216e-01 0.321 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.770216e-01 0.321 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 4.809506e-01 0.318 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.846447e-01 0.315 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 4.896474e-01 0.310 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.912011e-01 0.309 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.912011e-01 0.309 0 0
PKA activation in glucagon signalling R-HSA-164378 4.912011e-01 0.309 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.912011e-01 0.309 0 0
GAB1 signalosome R-HSA-180292 4.912011e-01 0.309 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.912011e-01 0.309 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.912011e-01 0.309 0 0
Tie2 Signaling R-HSA-210993 4.912011e-01 0.309 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.917332e-01 0.308 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.932959e-01 0.307 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.932959e-01 0.307 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.975821e-01 0.303 0 0
HCN channels R-HSA-1296061 4.975821e-01 0.303 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.975821e-01 0.303 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.975821e-01 0.303 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.975821e-01 0.303 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.975821e-01 0.303 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.975821e-01 0.303 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.975821e-01 0.303 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.975821e-01 0.303 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.975821e-01 0.303 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.975821e-01 0.303 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.975821e-01 0.303 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.975821e-01 0.303 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.997856e-01 0.301 0 0
Extension of Telomeres R-HSA-180786 5.024590e-01 0.299 0 0
Amino acid transport across the plasma membrane R-HSA-352230 5.024590e-01 0.299 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 5.038794e-01 0.298 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.049321e-01 0.297 0 0
Translation of Structural Proteins R-HSA-9694635 5.106090e-01 0.292 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.131934e-01 0.290 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.131934e-01 0.290 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.131934e-01 0.290 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.131934e-01 0.290 0 0
Sodium/Calcium exchangers R-HSA-425561 5.131934e-01 0.290 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.140886e-01 0.289 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.193504e-01 0.285 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.193504e-01 0.285 0 0
Maturation of nucleoprotein R-HSA-9694631 5.193504e-01 0.285 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.202306e-01 0.284 0 0
Cristae formation R-HSA-8949613 5.236214e-01 0.281 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.236214e-01 0.281 0 0
G alpha (12/13) signalling events R-HSA-416482 5.252529e-01 0.280 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.270910e-01 0.278 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.270910e-01 0.278 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.328040e-01 0.273 0 0
Toll-like Receptor Cascades R-HSA-168898 5.347598e-01 0.272 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.352421e-01 0.271 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.352421e-01 0.271 0 0
MAP kinase activation R-HSA-450294 5.352823e-01 0.271 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.432887e-01 0.265 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 5.466318e-01 0.262 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.466318e-01 0.262 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.466318e-01 0.262 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.466318e-01 0.262 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.466318e-01 0.262 0 0
Signaling by NODAL R-HSA-1181150 5.466318e-01 0.262 0 0
HIV elongation arrest and recovery R-HSA-167287 5.468976e-01 0.262 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.468976e-01 0.262 0 0
Pyroptosis R-HSA-5620971 5.468976e-01 0.262 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.468976e-01 0.262 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.476718e-01 0.261 0 0
Disorders of Nervous System Development R-HSA-9697154 5.476718e-01 0.261 0 0
Pervasive developmental disorders R-HSA-9005895 5.476718e-01 0.261 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.476718e-01 0.261 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.476718e-01 0.261 0 0
Regulation of IFNG signaling R-HSA-877312 5.476718e-01 0.261 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.476718e-01 0.261 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.476718e-01 0.261 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 5.476718e-01 0.261 0 0
Estrogen biosynthesis R-HSA-193144 5.476718e-01 0.261 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.500712e-01 0.260 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.500712e-01 0.260 0 0
Activation of AMPA receptors R-HSA-399710 5.520477e-01 0.258 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.520477e-01 0.258 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.520477e-01 0.258 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.520477e-01 0.258 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.520477e-01 0.258 0 0
Activation of AKT2 R-HSA-165158 5.520477e-01 0.258 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.520477e-01 0.258 0 0
Reelin signalling pathway R-HSA-8866376 5.520477e-01 0.258 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.520477e-01 0.258 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.520477e-01 0.258 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.520477e-01 0.258 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.520477e-01 0.258 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.520477e-01 0.258 0 0
Leishmania infection R-HSA-9658195 5.592472e-01 0.252 0 0
Parasitic Infection Pathways R-HSA-9824443 5.592472e-01 0.252 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.672150e-01 0.246 0 0
Voltage gated Potassium channels R-HSA-1296072 5.679220e-01 0.246 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.695664e-01 0.244 0 0
DARPP-32 events R-HSA-180024 5.695664e-01 0.244 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.695664e-01 0.244 0 0
RSV-host interactions R-HSA-9833110 5.705167e-01 0.244 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.729839e-01 0.242 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.729839e-01 0.242 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.729839e-01 0.242 0 0
Neddylation R-HSA-8951664 5.749963e-01 0.240 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.803988e-01 0.236 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 5.803988e-01 0.236 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.803988e-01 0.236 0 0
Processing of SMDT1 R-HSA-8949664 5.803988e-01 0.236 0 0
Frs2-mediated activation R-HSA-170968 5.803988e-01 0.236 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.803988e-01 0.236 0 0
Maturation of nucleoprotein R-HSA-9683610 5.803988e-01 0.236 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.803988e-01 0.236 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.827663e-01 0.235 0 0
IGF1R signaling cascade R-HSA-2428924 5.828613e-01 0.234 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.852295e-01 0.233 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 5.852295e-01 0.233 1 1
Signaling by TGFBR3 R-HSA-9839373 5.852295e-01 0.233 0 0
Elastic fibre formation R-HSA-1566948 5.876419e-01 0.231 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.876419e-01 0.231 0 0
DAP12 signaling R-HSA-2424491 5.915881e-01 0.228 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.915881e-01 0.228 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.915881e-01 0.228 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.951435e-01 0.225 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.982029e-01 0.223 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.983598e-01 0.223 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.983598e-01 0.223 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.006116e-01 0.221 0 0
Plus-strand DNA synthesis R-HSA-164525 6.006116e-01 0.221 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.006116e-01 0.221 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.006116e-01 0.221 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.006116e-01 0.221 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.006116e-01 0.221 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.006116e-01 0.221 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.006116e-01 0.221 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.006116e-01 0.221 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.006116e-01 0.221 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.006116e-01 0.221 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.006116e-01 0.221 0 0
Ceramide signalling R-HSA-193681 6.006116e-01 0.221 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.006116e-01 0.221 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.006116e-01 0.221 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.006116e-01 0.221 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.006116e-01 0.221 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.006116e-01 0.221 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.006116e-01 0.221 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.068593e-01 0.217 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.068593e-01 0.217 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.113490e-01 0.214 0 0
HDL assembly R-HSA-8963896 6.113490e-01 0.214 0 0
cGMP effects R-HSA-418457 6.113490e-01 0.214 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.113490e-01 0.214 0 0
Physiological factors R-HSA-5578768 6.113490e-01 0.214 0 0
Prolactin receptor signaling R-HSA-1170546 6.113490e-01 0.214 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.113490e-01 0.214 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.113490e-01 0.214 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.113490e-01 0.214 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.185927e-01 0.209 0 0
Stimuli-sensing channels R-HSA-2672351 6.185927e-01 0.209 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 6.227259e-01 0.206 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.227259e-01 0.206 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.227259e-01 0.206 0 0
Signaling by KIT in disease R-HSA-9669938 6.227259e-01 0.206 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.255508e-01 0.204 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.255508e-01 0.204 0 0
Generation of second messenger molecules R-HSA-202433 6.255508e-01 0.204 0 0
SLC-mediated transport of amino acids R-HSA-9958863 6.280139e-01 0.202 0 0
Inwardly rectifying K+ channels R-HSA-1296065 6.335661e-01 0.198 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.335661e-01 0.198 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.341247e-01 0.198 0 0
Rab regulation of trafficking R-HSA-9007101 6.400130e-01 0.194 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.405229e-01 0.193 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.405229e-01 0.193 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 6.436971e-01 0.191 0 0
HDL clearance R-HSA-8964011 6.439132e-01 0.191 0 0
Signaling by LTK in cancer R-HSA-9842640 6.439132e-01 0.191 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 6.439132e-01 0.191 0 0
Uncoating of the HIV Virion R-HSA-162585 6.439132e-01 0.191 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.439132e-01 0.191 0 0
MET Receptor Activation R-HSA-6806942 6.439132e-01 0.191 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.439132e-01 0.191 0 0
Abacavir transmembrane transport R-HSA-2161517 6.439132e-01 0.191 0 0
Lactose synthesis R-HSA-5653890 6.439132e-01 0.191 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.439132e-01 0.191 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 6.439132e-01 0.191 0 0
Neurofascin interactions R-HSA-447043 6.439132e-01 0.191 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.459156e-01 0.190 0 0
Interleukin-20 family signaling R-HSA-8854691 6.460605e-01 0.190 0 0
Formation of the ureteric bud R-HSA-9830674 6.460605e-01 0.190 0 0
G-protein beta:gamma signalling R-HSA-397795 6.534775e-01 0.185 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.534775e-01 0.185 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.612826e-01 0.180 0 0
RAB geranylgeranylation R-HSA-8873719 6.620224e-01 0.179 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.679419e-01 0.175 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.679419e-01 0.175 0 0
Activation of SMO R-HSA-5635838 6.679419e-01 0.175 0 0
Killing mechanisms R-HSA-9664420 6.679419e-01 0.175 0 0
Attachment and Entry R-HSA-9678110 6.679419e-01 0.175 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.679419e-01 0.175 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.679419e-01 0.175 0 0
Prolonged ERK activation events R-HSA-169893 6.679419e-01 0.175 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.683520e-01 0.175 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.683520e-01 0.175 0 0
Interleukin-6 family signaling R-HSA-6783589 6.683520e-01 0.175 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.683520e-01 0.175 0 0
Mitochondrial RNA degradation R-HSA-9836573 6.683520e-01 0.175 0 0
The phototransduction cascade R-HSA-2514856 6.690256e-01 0.175 1 0
Interleukin-17 signaling R-HSA-448424 6.703641e-01 0.174 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.726505e-01 0.172 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.726505e-01 0.172 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.726505e-01 0.172 0 0
Aquaporin-mediated transport R-HSA-445717 6.765520e-01 0.170 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.765520e-01 0.170 0 0
Integration of energy metabolism R-HSA-163685 6.776270e-01 0.169 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.825222e-01 0.166 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.825222e-01 0.166 0 0
PTK6 Expression R-HSA-8849473 6.825222e-01 0.166 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.825222e-01 0.166 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.825222e-01 0.166 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.825222e-01 0.166 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.825222e-01 0.166 0 0
VLDL clearance R-HSA-8964046 6.825222e-01 0.166 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.825222e-01 0.166 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.825222e-01 0.166 0 0
Netrin mediated repulsion signals R-HSA-418886 6.825222e-01 0.166 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.825222e-01 0.166 0 0
CHL1 interactions R-HSA-447041 6.825222e-01 0.166 0 0
HDMs demethylate histones R-HSA-3214842 6.895979e-01 0.161 0 0
G protein gated Potassium channels R-HSA-1296059 6.895979e-01 0.161 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.895979e-01 0.161 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.895979e-01 0.161 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.895979e-01 0.161 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 6.895979e-01 0.161 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.895979e-01 0.161 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.895979e-01 0.161 0 0
Formation of the nephric duct R-HSA-9830364 6.895979e-01 0.161 0 0
Heme signaling R-HSA-9707616 6.906834e-01 0.161 0 0
Signal amplification R-HSA-392518 6.910768e-01 0.160 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.910768e-01 0.160 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.910768e-01 0.160 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.936435e-01 0.159 0 0
Disorders of Developmental Biology R-HSA-9675151 6.936435e-01 0.159 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.936435e-01 0.159 0 0
Coenzyme A biosynthesis R-HSA-196783 6.936435e-01 0.159 0 0
Synthesis of PG R-HSA-1483148 6.936435e-01 0.159 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.969105e-01 0.157 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.085968e-01 0.150 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.087530e-01 0.150 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.087530e-01 0.150 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.098037e-01 0.149 0 0
Urea cycle R-HSA-70635 7.098037e-01 0.149 0 0
TRP channels R-HSA-3295583 7.098037e-01 0.149 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.098037e-01 0.149 0 0
Proteasome assembly R-HSA-9907900 7.105742e-01 0.148 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.149534e-01 0.146 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.151137e-01 0.146 0 0
Leishmania phagocytosis R-HSA-9664417 7.151137e-01 0.146 0 0
Parasite infection R-HSA-9664407 7.151137e-01 0.146 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.156659e-01 0.145 1 0
Reverse Transcription of HIV RNA R-HSA-162589 7.169471e-01 0.145 0 0
Minus-strand DNA synthesis R-HSA-164516 7.169471e-01 0.145 0 0
phospho-PLA2 pathway R-HSA-111995 7.169471e-01 0.145 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.169471e-01 0.145 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.169471e-01 0.145 0 0
MET receptor recycling R-HSA-8875656 7.169471e-01 0.145 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.169471e-01 0.145 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.169471e-01 0.145 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.169471e-01 0.145 0 0
Fructose biosynthesis R-HSA-5652227 7.169471e-01 0.145 0 0
Activation of RAS in B cells R-HSA-1169092 7.169471e-01 0.145 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.169471e-01 0.145 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.169471e-01 0.145 0 0
RSK activation R-HSA-444257 7.169471e-01 0.145 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.169471e-01 0.145 0 0
Alpha-defensins R-HSA-1462054 7.169471e-01 0.145 0 0
GDP-fucose biosynthesis R-HSA-6787639 7.176776e-01 0.144 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 7.176776e-01 0.144 0 0
Specification of primordial germ cells R-HSA-9827857 7.176776e-01 0.144 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.176776e-01 0.144 0 0
Insulin receptor signalling cascade R-HSA-74751 7.177280e-01 0.144 0 0
Extracellular matrix organization R-HSA-1474244 7.199298e-01 0.143 0 0
Asparagine N-linked glycosylation R-HSA-446203 7.255153e-01 0.139 0 0
Somitogenesis R-HSA-9824272 7.258323e-01 0.139 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.289813e-01 0.137 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.289813e-01 0.137 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.289813e-01 0.137 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.295992e-01 0.137 0 0
Protein-protein interactions at synapses R-HSA-6794362 7.378517e-01 0.132 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.401038e-01 0.131 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.401038e-01 0.131 0 0
Apoptotic factor-mediated response R-HSA-111471 7.401038e-01 0.131 0 0
Nephron development R-HSA-9831926 7.401038e-01 0.131 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.471486e-01 0.127 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.476410e-01 0.126 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.476410e-01 0.126 0 0
mRNA Editing R-HSA-75072 7.476410e-01 0.126 0 0
Calcineurin activates NFAT R-HSA-2025928 7.476410e-01 0.126 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.476410e-01 0.126 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.476410e-01 0.126 0 0
Expression of NOTCH2NL genes R-HSA-9911233 7.476410e-01 0.126 0 0
Interleukin-1 processing R-HSA-448706 7.476410e-01 0.126 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.476410e-01 0.126 0 0
Kidney development R-HSA-9830369 7.552032e-01 0.122 0 0
MET promotes cell motility R-HSA-8875878 7.573088e-01 0.121 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.573088e-01 0.121 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 7.573088e-01 0.121 0 0
Inositol phosphate metabolism R-HSA-1483249 7.592970e-01 0.120 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.609880e-01 0.119 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.609880e-01 0.119 0 0
Specification of the neural plate border R-HSA-9834899 7.609880e-01 0.119 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.609880e-01 0.119 0 0
Crosslinking of collagen fibrils R-HSA-2243919 7.609880e-01 0.119 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 7.609880e-01 0.119 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.609880e-01 0.119 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.720297e-01 0.112 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 7.720297e-01 0.112 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.720297e-01 0.112 0 0
DNA replication initiation R-HSA-68952 7.750081e-01 0.111 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 7.750081e-01 0.111 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.750081e-01 0.111 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.750081e-01 0.111 0 0
Interleukin-27 signaling R-HSA-9020956 7.750081e-01 0.111 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.750081e-01 0.111 0 0
Maturation of spike protein R-HSA-9683686 7.750081e-01 0.111 0 0
Sperm Motility And Taxes R-HSA-1300642 7.750081e-01 0.111 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.750081e-01 0.111 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.750081e-01 0.111 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 7.787352e-01 0.109 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.804009e-01 0.108 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.804009e-01 0.108 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.804009e-01 0.108 0 0
Creatine metabolism R-HSA-71288 7.804009e-01 0.108 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.805456e-01 0.108 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.815175e-01 0.107 0 0
Potassium Channels R-HSA-1296071 7.815175e-01 0.107 0 0
HIV Transcription Elongation R-HSA-167169 7.860390e-01 0.105 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.860390e-01 0.105 0 0
Metabolism of amino acids and derivatives R-HSA-71291 7.891591e-01 0.103 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.958311e-01 0.099 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.984158e-01 0.098 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.984158e-01 0.098 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 7.984158e-01 0.098 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.994088e-01 0.097 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.994088e-01 0.097 0 0
Chylomicron assembly R-HSA-8963888 7.994088e-01 0.097 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 7.994088e-01 0.097 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.060007e-01 0.094 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.102162e-01 0.091 0 0
Intra-Golgi traffic R-HSA-6811438 8.119877e-01 0.090 0 0
Signaling by PDGF R-HSA-186797 8.119980e-01 0.090 0 0
Attachment and Entry R-HSA-9694614 8.151077e-01 0.089 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.151077e-01 0.089 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 8.151077e-01 0.089 0 0
Neurexins and neuroligins R-HSA-6794361 8.164796e-01 0.088 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.211645e-01 0.086 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.211645e-01 0.086 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.211645e-01 0.086 0 0
Plasmalogen biosynthesis R-HSA-75896 8.211645e-01 0.086 0 0
ERKs are inactivated R-HSA-202670 8.211645e-01 0.086 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.211645e-01 0.086 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.211645e-01 0.086 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.221723e-01 0.085 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.239640e-01 0.084 0 0
Nucleotide biosynthesis R-HSA-8956320 8.272215e-01 0.082 0 0
Signaling by FGFR in disease R-HSA-1226099 8.283762e-01 0.082 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.288672e-01 0.082 1 1
FRS-mediated FGFR4 signaling R-HSA-5654712 8.305516e-01 0.081 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.305516e-01 0.081 0 0
LDL clearance R-HSA-8964038 8.305516e-01 0.081 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.305516e-01 0.081 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.332556e-01 0.079 0 0
TBC/RABGAPs R-HSA-8854214 8.353016e-01 0.078 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.364215e-01 0.078 0 0
Iron uptake and transport R-HSA-917937 8.372651e-01 0.077 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.405617e-01 0.075 0 0
Interleukin-35 Signalling R-HSA-8984722 8.405617e-01 0.075 0 0
Acetylation R-HSA-156582 8.405617e-01 0.075 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.405617e-01 0.075 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.405617e-01 0.075 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.405617e-01 0.075 0 0
OAS antiviral response R-HSA-8983711 8.405617e-01 0.075 0 0
Mitochondrial protein degradation R-HSA-9837999 8.410985e-01 0.075 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.448217e-01 0.073 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.448217e-01 0.073 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.448217e-01 0.073 0 0
Mitochondrial mRNA modification R-HSA-9937008 8.448217e-01 0.073 0 0
DAP12 interactions R-HSA-2172127 8.460220e-01 0.073 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.483124e-01 0.071 0 0
Hyaluronan metabolism R-HSA-2142845 8.483124e-01 0.071 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.483124e-01 0.071 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.507645e-01 0.070 0 0
Acetylcholine binding and downstream events R-HSA-181431 8.578561e-01 0.067 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 8.578561e-01 0.067 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.578561e-01 0.067 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.578561e-01 0.067 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.578561e-01 0.067 0 0
Chylomicron remodeling R-HSA-8963901 8.578561e-01 0.067 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 8.578561e-01 0.067 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.578561e-01 0.067 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.579909e-01 0.067 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.579909e-01 0.067 0 0
Complex III assembly R-HSA-9865881 8.579909e-01 0.067 0 0
Integrin cell surface interactions R-HSA-216083 8.617432e-01 0.065 0 0
IRS-mediated signalling R-HSA-112399 8.651750e-01 0.063 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.692022e-01 0.061 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.701301e-01 0.060 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.701301e-01 0.060 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.701301e-01 0.060 0 0
Hyaluronan degradation R-HSA-2160916 8.701301e-01 0.060 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.732754e-01 0.059 0 0
Hydrolysis of LPC R-HSA-1483115 8.732754e-01 0.059 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 8.732754e-01 0.059 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 8.732754e-01 0.059 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 8.732754e-01 0.059 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 8.732754e-01 0.059 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.732754e-01 0.059 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.732754e-01 0.059 0 0
Ciprofloxacin ADME R-HSA-9793528 8.732754e-01 0.059 0 0
Signal regulatory protein family interactions R-HSA-391160 8.732754e-01 0.059 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.732754e-01 0.059 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.732754e-01 0.059 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.755251e-01 0.058 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.795726e-01 0.056 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.813078e-01 0.055 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.813078e-01 0.055 0 0
Peroxisomal protein import R-HSA-9033241 8.813588e-01 0.055 0 0
COPII-mediated vesicle transport R-HSA-204005 8.816188e-01 0.055 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.870229e-01 0.052 0 0
Signaling by Activin R-HSA-1502540 8.870229e-01 0.052 0 0
Transport and metabolism of PAPS R-HSA-174362 8.870229e-01 0.052 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.870229e-01 0.052 0 0
Protein lipoylation R-HSA-9857492 8.870229e-01 0.052 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 8.870229e-01 0.052 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.870229e-01 0.052 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.870229e-01 0.052 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.870229e-01 0.052 0 0
Other semaphorin interactions R-HSA-416700 8.870229e-01 0.052 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.886422e-01 0.051 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.915896e-01 0.050 0 0
Signaling by BMP R-HSA-201451 8.915896e-01 0.050 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.915896e-01 0.050 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.958527e-01 0.048 0 0
Pentose phosphate pathway R-HSA-71336 8.970953e-01 0.047 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.972495e-01 0.047 0 0
PI3K Cascade R-HSA-109704 8.986425e-01 0.046 0 0
Azathioprine ADME R-HSA-9748787 8.986425e-01 0.046 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.992797e-01 0.046 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.992797e-01 0.046 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.992797e-01 0.046 0 0
Atorvastatin ADME R-HSA-9754706 8.992797e-01 0.046 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.992797e-01 0.046 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.992797e-01 0.046 0 0
Mitochondrial Uncoupling R-HSA-166187 8.992797e-01 0.046 0 0
Telomere Extension By Telomerase R-HSA-171319 9.010383e-01 0.045 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.010383e-01 0.045 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.010383e-01 0.045 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.010383e-01 0.045 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.025070e-01 0.045 0 0
Interleukin-2 family signaling R-HSA-451927 9.049663e-01 0.043 0 0
mRNA Capping R-HSA-72086 9.097136e-01 0.041 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.097136e-01 0.041 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.097136e-01 0.041 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.097136e-01 0.041 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.097136e-01 0.041 0 0
Phase 2 - plateau phase R-HSA-5576893 9.102075e-01 0.041 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.102075e-01 0.041 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.102075e-01 0.041 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.102075e-01 0.041 0 0
Passive transport by Aquaporins R-HSA-432047 9.102075e-01 0.041 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 9.102075e-01 0.041 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.102075e-01 0.041 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.102075e-01 0.041 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.102075e-01 0.041 0 0
Maturation of spike protein R-HSA-9694548 9.122884e-01 0.040 0 0
tRNA processing R-HSA-72306 9.144863e-01 0.039 0 0
Formation of the cornified envelope R-HSA-6809371 9.174734e-01 0.037 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.176500e-01 0.037 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.176721e-01 0.037 0 0
G alpha (s) signalling events R-HSA-418555 9.181087e-01 0.037 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.184551e-01 0.037 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.190939e-01 0.037 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.199502e-01 0.036 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.199502e-01 0.036 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.199502e-01 0.036 0 0
Choline catabolism R-HSA-6798163 9.199502e-01 0.036 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.206994e-01 0.036 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.249672e-01 0.034 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.249672e-01 0.034 0 0
Activation of GABAB receptors R-HSA-991365 9.254136e-01 0.034 0 0
GABA B receptor activation R-HSA-977444 9.254136e-01 0.034 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.281216e-01 0.032 0 0
PKA activation R-HSA-163615 9.286363e-01 0.032 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.286363e-01 0.032 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.286363e-01 0.032 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.286363e-01 0.032 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.354263e-01 0.029 0 0
SLC transporter disorders R-HSA-5619102 9.354804e-01 0.029 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.363803e-01 0.029 0 0
HDL remodeling R-HSA-8964058 9.363803e-01 0.029 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.363803e-01 0.029 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.363803e-01 0.029 0 0
Diseases of hemostasis R-HSA-9671793 9.363803e-01 0.029 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.363803e-01 0.029 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.363803e-01 0.029 0 0
Other interleukin signaling R-HSA-449836 9.363803e-01 0.029 0 0
Surfactant metabolism R-HSA-5683826 9.367142e-01 0.028 0 0
Cardiogenesis R-HSA-9733709 9.377648e-01 0.028 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.377648e-01 0.028 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.377648e-01 0.028 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.408832e-01 0.026 0 0
Interferon gamma signaling R-HSA-877300 9.426116e-01 0.026 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.432844e-01 0.025 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.432844e-01 0.025 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.432844e-01 0.025 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.432844e-01 0.025 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.432844e-01 0.025 0 0
Pregnenolone biosynthesis R-HSA-196108 9.432844e-01 0.025 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.433586e-01 0.025 0 0
Heme degradation R-HSA-189483 9.433586e-01 0.025 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.438747e-01 0.025 0 0
Gastrulation R-HSA-9758941 9.442396e-01 0.025 0 0
Signaling by Insulin receptor R-HSA-74752 9.464488e-01 0.024 0 0
eNOS activation R-HSA-203615 9.484717e-01 0.023 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.484717e-01 0.023 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.494396e-01 0.023 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.494396e-01 0.023 0 0
ERK/MAPK targets R-HSA-198753 9.494396e-01 0.023 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.494396e-01 0.023 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.494396e-01 0.023 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.494396e-01 0.023 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.494396e-01 0.023 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.510825e-01 0.022 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.518370e-01 0.021 0 0
Metabolism of polyamines R-HSA-351202 9.518370e-01 0.021 0 0
Collagen formation R-HSA-1474290 9.528338e-01 0.021 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.531426e-01 0.021 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.549272e-01 0.020 0 0
Serine metabolism R-HSA-977347 9.549272e-01 0.020 0 0
Androgen biosynthesis R-HSA-193048 9.549272e-01 0.020 0 0
Ribavirin ADME R-HSA-9755088 9.549272e-01 0.020 0 0
Collagen degradation R-HSA-1442490 9.554159e-01 0.020 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.574069e-01 0.019 0 0
RNA Polymerase III Transcription R-HSA-74158 9.574069e-01 0.019 0 0
Triglyceride catabolism R-HSA-163560 9.574069e-01 0.019 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.574069e-01 0.019 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.587480e-01 0.018 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.598194e-01 0.018 0 0
Notch-HLH transcription pathway R-HSA-350054 9.598194e-01 0.018 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.598194e-01 0.018 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.598194e-01 0.018 0 0
Cellular hexose transport R-HSA-189200 9.598194e-01 0.018 0 0
Fructose metabolism R-HSA-5652084 9.598194e-01 0.018 0 0
Mitochondrial biogenesis R-HSA-1592230 9.635965e-01 0.016 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.641809e-01 0.016 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.641809e-01 0.016 0 0
Biosynthesis of maresins R-HSA-9018682 9.641809e-01 0.016 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.659676e-01 0.015 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.678331e-01 0.014 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.680692e-01 0.014 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.680692e-01 0.014 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.710275e-01 0.013 0 0
Tryptophan catabolism R-HSA-71240 9.710275e-01 0.013 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.715356e-01 0.013 0 0
Fertilization R-HSA-1187000 9.715356e-01 0.013 0 0
Laminin interactions R-HSA-3000157 9.715356e-01 0.013 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.715356e-01 0.013 0 0
Metabolism of steroid hormones R-HSA-196071 9.722089e-01 0.012 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.731690e-01 0.012 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.731690e-01 0.012 0 0
MET activates PTK2 signaling R-HSA-8874081 9.746258e-01 0.011 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.746258e-01 0.011 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.746258e-01 0.011 0 0
Abacavir ADME R-HSA-2161522 9.746258e-01 0.011 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.746258e-01 0.011 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.761532e-01 0.010 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.773808e-01 0.010 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.773808e-01 0.010 0 0
PPARA activates gene expression R-HSA-1989781 9.774297e-01 0.010 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.782827e-01 0.010 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.783753e-01 0.009 0 0
Dectin-2 family R-HSA-5621480 9.792155e-01 0.009 0 0
Synthesis of PA R-HSA-1483166 9.792155e-01 0.009 0 0
Insulin receptor recycling R-HSA-77387 9.798367e-01 0.009 0 0
Prednisone ADME R-HSA-9757110 9.798367e-01 0.009 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.798687e-01 0.009 0 0
ECM proteoglycans R-HSA-3000178 9.798868e-01 0.009 0 0
G alpha (q) signalling events R-HSA-416476 9.800761e-01 0.009 1 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.809752e-01 0.008 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.829280e-01 0.007 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 9.839028e-01 0.007 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.839028e-01 0.007 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.839780e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.839780e-01 0.007 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.839780e-01 0.007 0 0
GABA receptor activation R-HSA-977443 9.840769e-01 0.007 0 0
Cargo concentration in the ER R-HSA-5694530 9.857179e-01 0.006 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.867024e-01 0.006 0 0
DAG1 glycosylations R-HSA-8931838 9.872690e-01 0.006 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.875256e-01 0.005 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.878313e-01 0.005 0 0
Cholesterol biosynthesis R-HSA-191273 9.887375e-01 0.005 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.891808e-01 0.005 0 0
PI Metabolism R-HSA-1483255 9.891894e-01 0.005 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.898844e-01 0.004 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.902099e-01 0.004 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.915107e-01 0.004 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.919627e-01 0.004 0 0
Glycosphingolipid transport R-HSA-9845576 9.928358e-01 0.003 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.928358e-01 0.003 0 0
NCAM1 interactions R-HSA-419037 9.936141e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.936141e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.936141e-01 0.003 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.938443e-01 0.003 0 0
Paracetamol ADME R-HSA-9753281 9.940803e-01 0.003 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.949264e-01 0.002 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.954777e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.955727e-01 0.002 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.959676e-01 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.959692e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.960562e-01 0.002 0 0
Heme biosynthesis R-HSA-189451 9.964072e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.964386e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.964386e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.965269e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.968714e-01 0.001 0 0
Pyrimidine catabolism R-HSA-73621 9.971457e-01 0.001 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.971457e-01 0.001 0 0
Defensins R-HSA-1461973 9.971457e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.973337e-01 0.001 0 0
Methylation R-HSA-156581 9.974560e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.974560e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.976358e-01 0.001 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.977325e-01 0.001 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.977876e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.980757e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.981987e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.982643e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.983945e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.984346e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.985691e-01 0.001 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.987086e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.987274e-01 0.001 0 0
G alpha (i) signalling events R-HSA-418594 9.987869e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.988521e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.988528e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.988634e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.991220e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.991953e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.992083e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.994048e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.994774e-01 0.000 1 0
Antimicrobial peptides R-HSA-6803157 9.995798e-01 0.000 0 0
Keratinization R-HSA-6805567 9.996942e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.997146e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.997457e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.998039e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998726e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998865e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998865e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998865e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999099e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999197e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999418e-01 0.000 1 0
Interleukin-10 signaling R-HSA-6783783 9.999493e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999493e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999549e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999549e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999588e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999642e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999642e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999690e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999746e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999943e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999950e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999968e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999976e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999976e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999981e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999982e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999984e-01 0.000 1 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999987e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999991e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999991e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999992e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999992e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999992e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999992e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999992e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999994e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999996e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999997e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 1 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways