MPSK1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
O15085	S1295	Sugiyama	ARHGEF11 KIAA0380	PEQEDMGLCSLEHLPPRtRNsGIWEsPELDRNLAEDASSTE
O15085	T1292	Sugiyama	ARHGEF11 KIAA0380	GERPEQEDMGLCSLEHLPPRtRNsGIWEsPELDRNLAEDAS
O15371	T46	Sugiyama	EIF3D EIF3S7	RDMPyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGG
O43390	T134	Sugiyama	HNRNPR HNRPR	KVQESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O43390	T142	Sugiyama	HNRNPR HNRPR	PDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYSGVQPG
O60506	T131	Sugiyama	SYNCRIP HNRPQ NSAP1	KVADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O60506	T139	Sugiyama	SYNCRIP HNRPQ NSAP1	PDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYSGQQPs
O75716	S197	GPS6\|SIGNOR\|EPSD\|PSP	STK16 MPSK1 PKL12 TSF1	VEGSRQALtLQDWAAQRCTIsyRAPELFSVQSHCVIDERTD
O75716	T185	GPS6\|SIGNOR\|EPSD\|PSP	STK16 MPSK1 PKL12 TSF1	MDLGSMNQACIHVEGSRQALtLQDWAAQRCTIsyRAPELFS
O75716	Y198	SIGNOR\|EPSD\|PSP	STK16 MPSK1 PKL12 TSF1	EGSRQALtLQDWAAQRCTIsyRAPELFSVQSHCVIDERTDV
O96019	T72	Sugiyama	ACTL6A BAF53 BAF53A INO80K	TLMEIDGDKGKQGGPtyyIDtNALRVPRENMEAIsPLKNGM
P00491	S163	Sugiyama	PNP NP	GQNPLRGPNDERFGDRFPAMsDAyDRtMRQRALstWKQMGE
P00966	T208	Sugiyama	ASS1 ASS	IsyEAGILENPKNQAPPGLytKtQDPAKAPNtPDILEIEFK
P04040	T29	Sugiyama	CAT	SDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRGP
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083	S201	Sugiyama	ANXA1 ANX1 LPC1	LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406	T246	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07437	T55	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07900	S50	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P08195	T599	Sugiyama	SLC3A2 MDU1	QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238	S45	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	T89	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	KELKIDIIPNPQERtLtLVDtGIGMtKADLINNLGtIAKSG
P08865	T94	Sugiyama	RPSA LAMBR LAMR1	VsVIssRNtGQRAVLKFAAAtGAtPIAGRFtPGTFTNQIQA
P09382	S63	Sugiyama	LGALS1	CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P11142	T45	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14625	S106	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625	T519	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy
P14625	T522	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	NRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIyFMA
P14625	T675	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	sGNMERIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLIR
P15259	T96	Sugiyama	PGAM2 PGAMM	QMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEEQVKIWR
P17066	T47	Sugiyama	HSPA6 HSP70B'	RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P18669	T96	Sugiyama	PGAM1 PGAMA CDABP0006	QMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEAQVKIWR
P19338	T464	Sugiyama	NCL	KTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWsGE
P20290	T182	Sugiyama	BTF3 NACB OK/SW-cl.8	LRRLAEALPKQsVDGKAPLAtGEDDDDEVPDLVENFDEAsK
P20618	Y158	Sugiyama	PSMB1 PSC5	IGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLD
P22626	S225	Sugiyama	HNRNPA2B1 HNRPA2B1	GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P27448	S42	Sugiyama	MARK3 CTAK1 EMK2	GDGRQEVTSRTSRSGARCRNsIAsCADEQPHIGNyRLLKTI
P27448	S45	Sugiyama	MARK3 CTAK1 EMK2	RQEVTSRTSRSGARCRNsIAsCADEQPHIGNyRLLKTIGKG
P29692	S162	Sugiyama	EEF1D EF1D	AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692	S70	Sugiyama	EEF1D EF1D	IARARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVE
P30041	T48	Sugiyama	PRDX6 AOP2 KIAA0106	FLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKRNVKL
P30050	S157	Sugiyama	RPL12	QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P34931	T47	Sugiyama	HSPA1L	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P35269	S449	Sugiyama	GTF2F1 RAP74	PQsLsGKstPQPPsGKttPNsGDVQVTEDAVRRYLTRKPMT
P35611	T16	Sugiyama	ADD1 ADDA	_____MNGDsRAAVVtsPPPttAPHKERyFDRVDENNPEyL
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646	T111	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VAFtADGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDP
P38646	T94	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46777	S172	Sugiyama	RPL5 MSTP030	RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777	S176	Sugiyama	RPL5 MSTP030	GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P47712	S454	Sugiyama	PLA2G4A CPLA2 PLA2G4	ssDsDDEsHEPKGtENEDAGsDyQsDNQASWIHRMIMALVS
P48643	T269	Sugiyama	CCT5 CCTE KIAA0098	AILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMI
P48741	T47	Sugiyama	HSPA7 HSP70B	RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49411	T276	Sugiyama	TUFM	DLEKPFLLPVEAVYSVPGRGtVVTGTLERGILKKGDECELL
P50990	T286	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	MNFsKGEENLMDAQVKAIADtGANVVVtGGKVADMALHYAN
P53621	S266	Sugiyama	COPA	RGHyNNVSCAVFHPRQELILsNsEDKSIRVWDMSKRTGVQT
P54652	T46	Sugiyama	HSPA2	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P61254	T8	Sugiyama	RPL26	_____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61978	S81	Sugiyama	HNRNPK HNRPK	GGKNIKALRtDyNAsVsVPDssGPERILsISADIETIGEIL
P62191	T230	Sugiyama	PSMC1	yyEEMGIKPPKGVILyGPPGtGKTLLAKAVANQTsATFLRV
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62826	T66	Sugiyama	RAN ARA24 OK/SW-cl.81	EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62942	T28	Sugiyama	FKBP1A FKBP1 FKBP12	IsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPFK
P63173	T14	Sugiyama	RPL38	_______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P78371	T242	Sugiyama	CCT2 99D8.1 CCTB	KKIGVNQPKRIENAKILIANtGMDtDKIKIFGsRVRVDstA
Q00613	S363	Sugiyama	HSF1 HSTF1	AsVTALtDARGHTDtEGRPPsPPPtstPEKCLsVACLDKNE
Q12805	S382	Sugiyama	EFEMP1 FBLN3 FBNL	RNPCQDPyILTPENRCVCPVsNAMCRELPQSIVYKYMSIRS
Q13247	S303	Sugiyama	SRSF6 SFRS6 SRP55	ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q14568	S50	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14847	T104	Sugiyama	LASP1 MLN50	VRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsNIKyHE
Q16543	T370	Sugiyama	CDC37 CDC37A	EAKEGEEAGPGDPLLEAVPKtGDEKDVsV____________
Q562R1	T107	Sugiyama	ACTBL2	WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q6PKG0	T747	Sugiyama	LARP1 KIAA0731 LARP	PPVDPNQEVPPGPPRFQQVPtDALANKLFGAPEPstIARsL
Q8IZ73	T407	Sugiyama	RPUSD2 C15orf19	PIYNSVAWGPSRGRGGYIPKtNEELLRDLVAEHQAKQSLDV
Q8N0Y7	T96	Sugiyama	PGAM4 PGAM3	QMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEAQVKIWR
Q8NFD5	S1744	Sugiyama	ARID1B BAF250B DAN15 KIAA1235 OSA2	ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q92615	S589	Sugiyama	LARP4B KIAA0217 LARP5	ADAsVNtLPVVVSREPsVPAsCAVsAtyERsPsPAHLPDDP
Q9BQE3	S439	Sugiyama	TUBA1C TUBA6	SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BX95	S112	Sugiyama	SGPP1 SPP1	GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9H7N4	S498	Sugiyama	SCAF1 SFRS19 SRA1	GGLDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKK
Q9H7N4	S500	Sugiyama	SCAF1 SFRS19 SRA1	LDLRRKILTQRRERyRQRsPsPAPAPAPAAAAGPPTRKKSR
Q9UNX3	T8	Sugiyama	RPL26L1 RPL26P1	_____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ35	S2132	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRMsCFsRPsMsPtPLDRCRsPGMLEPLGssRtPMsVLQQA
Q9Y285	T504	Sugiyama	FARSA FARS FARSL FARSLA	LQMVYDsPLCRLDAEPRPPPtQEAA________________
Q9Y295	T100	GPS6\|SIGNOR	DRG1 NEDD3	LLSNLAGVYSEVAAYEFTTLttVPGVIRYKGAKIQLLDLPG
Q9Y295	T101	PSP	DRG1 NEDD3	LSNLAGVYSEVAAYEFTTLttVPGVIRYKGAKIQLLDLPGI

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Chromatin modifying enzymes	R-HSA-3247509	3.098537e-09	8.509
Chromatin organization	R-HSA-4839726	4.073303e-09	8.390
PKMTs methylate histone lysines	R-HSA-3214841	2.691482e-06	5.570
Gene expression (Transcription)	R-HSA-74160	3.044219e-06	5.517
Epigenetic regulation of gene expression	R-HSA-212165	9.289198e-06	5.032
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	3.090988e-05	4.510
HATs acetylate histones	R-HSA-3214847	5.443503e-05	4.264
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	5.497780e-05	4.260
RNA Polymerase II Transcription	R-HSA-73857	5.934598e-05	4.227
Generic Transcription Pathway	R-HSA-212436	4.654863e-05	4.332
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.483879e-04	3.829
ALK mutants bind TKIs	R-HSA-9700645	2.380580e-04	3.623
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	3.067399e-04	3.513
Regulation of PTEN gene transcription	R-HSA-8943724	3.211143e-04	3.493
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	3.880204e-04	3.411
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	4.285361e-04	3.368
PIP3 activates AKT signaling	R-HSA-1257604	6.320222e-04	3.199
Cellular Senescence	R-HSA-2559583	8.777951e-04	3.057
AKT phosphorylates targets in the cytosol	R-HSA-198323	8.667240e-04	3.062
Signaling by NTRK1 (TRKA)	R-HSA-187037	9.501207e-04	3.022
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	1.452131e-03	2.838
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.487542e-03	2.828
Signaling by NTRKs	R-HSA-166520	1.704565e-03	2.768
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.834933e-03	2.736
Oxidative Stress Induced Senescence	R-HSA-2559580	2.167479e-03	2.664
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.204715e-03	2.657
Intracellular signaling by second messengers	R-HSA-9006925	2.379181e-03	2.624
GRB2 events in ERBB2 signaling	R-HSA-1963640	2.814646e-03	2.551
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	2.837041e-03	2.547
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.814646e-03	2.551
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	3.013184e-03	2.521
PI3K/AKT Signaling in Cancer	R-HSA-2219528	3.088326e-03	2.510
PI3K events in ERBB2 signaling	R-HSA-1963642	3.425366e-03	2.465
Mitotic Prophase	R-HSA-68875	3.519437e-03	2.454
G1/S-Specific Transcription	R-HSA-69205	3.671545e-03	2.435
Polo-like kinase mediated events	R-HSA-156711	4.125896e-03	2.384
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.454227e-03	2.263
RNA Polymerase I Promoter Clearance	R-HSA-73854	5.331325e-03	2.273
Signaling by ERBB2 in Cancer	R-HSA-1227990	6.224276e-03	2.206
RNA Polymerase I Transcription	R-HSA-73864	6.240823e-03	2.205
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	5.885657e-03	2.230
Downregulation of ERBB2 signaling	R-HSA-8863795	6.224276e-03	2.206
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	7.004637e-03	2.155
Downregulation of ERBB4 signaling	R-HSA-1253288	1.383915e-02	1.859
Retrograde neurotrophin signalling	R-HSA-177504	9.305083e-03	2.031
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.210703e-02	1.917
Translation initiation complex formation	R-HSA-72649	7.679713e-03	2.115
Ribosomal scanning and start codon recognition	R-HSA-72702	9.175206e-03	2.037
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.154968e-02	1.937
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.154968e-02	1.937
Adrenoceptors	R-HSA-390696	1.383915e-02	1.859
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.196286e-02	1.922
Signaling downstream of RAS mutants	R-HSA-9649948	1.196286e-02	1.922
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.196286e-02	1.922
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.087777e-02	1.963
Signaling by ERBB2	R-HSA-1227986	1.280325e-02	1.893
Oncogenic MAPK signaling	R-HSA-6802957	1.040212e-02	1.983
TGFBR3 expression	R-HSA-9839394	1.376212e-02	1.861
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	7.962258e-03	2.099
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.266655e-03	2.139
Regulation of TP53 Activity	R-HSA-5633007	7.718083e-03	2.112
Breakdown of the nuclear lamina	R-HSA-352238	8.265147e-03	2.083
Signaling by RAS mutants	R-HSA-6802949	1.196286e-02	1.922
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	9.999609e-03	2.000
Prolonged ERK activation events	R-HSA-169893	1.323365e-02	1.878
mTORC1-mediated signalling	R-HSA-166208	9.212807e-03	2.036
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	1.323365e-02	1.878
Cell Cycle, Mitotic	R-HSA-69278	1.083893e-02	1.965
TCF dependent signaling in response to WNT	R-HSA-201681	1.124788e-02	1.949
MAP kinase activation	R-HSA-450294	1.385449e-02	1.858
Interleukin-17 signaling	R-HSA-448424	9.644321e-03	2.016
Nuclear Envelope Breakdown	R-HSA-2980766	9.999609e-03	2.000
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	8.577612e-03	2.067
Signaling by ALK in cancer	R-HSA-9700206	8.577612e-03	2.067
Regulation of CDH1 Gene Transcription	R-HSA-9764560	9.644321e-03	2.016
XBP1(S) activates chaperone genes	R-HSA-381038	1.190986e-02	1.924
Regulation of TP53 Expression	R-HSA-6804754	1.426760e-02	1.846
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.545872e-02	1.811
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.545872e-02	1.811
Signaling by PTK6	R-HSA-8848021	1.614356e-02	1.792
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.614356e-02	1.792
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.734170e-02	1.761
Activation of HOX genes during differentiation	R-HSA-5619507	1.734170e-02	1.761
IRE1alpha activates chaperones	R-HSA-381070	1.742800e-02	1.759
Uptake and function of anthrax toxins	R-HSA-5210891	1.808355e-02	1.743
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.875942e-02	1.727
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.869391e-02	1.728
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	1.962154e-02	1.707
SARS-CoV-1-host interactions	R-HSA-9692914	1.936546e-02	1.713
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.007162e-02	1.697
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	2.044050e-02	1.690
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.087183e-02	1.680
MET activates RAP1 and RAC1	R-HSA-8875555	2.140290e-02	1.670
Signaling by Leptin	R-HSA-2586552	2.140290e-02	1.670
Signaling by APC mutants	R-HSA-4839744	2.587823e-02	1.587
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.587823e-02	1.587
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.587823e-02	1.587
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.587823e-02	1.587
MAP2K and MAPK activation	R-HSA-5674135	2.456419e-02	1.610
HDACs deacetylate histones	R-HSA-3214815	2.516973e-02	1.599
Signaling by RAF1 mutants	R-HSA-9656223	2.456419e-02	1.610
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.431817e-02	1.614
Estrogen-dependent gene expression	R-HSA-9018519	2.291093e-02	1.640
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.297697e-02	1.639
Suppression of apoptosis	R-HSA-9635465	2.587823e-02	1.587
Axon guidance	R-HSA-422475	2.486861e-02	1.604
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	2.360691e-02	1.627
Maturation of nucleoprotein	R-HSA-9694631	2.390986e-02	1.621
Signaling by NOTCH3	R-HSA-9012852	2.516973e-02	1.599
Deubiquitination	R-HSA-5688426	2.603259e-02	1.584
PTEN Regulation	R-HSA-6807070	2.621828e-02	1.581
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.673822e-02	1.573
MTOR signalling	R-HSA-165159	2.673822e-02	1.573
PLCG1 events in ERBB2 signaling	R-HSA-1251932	3.027794e-02	1.519
GRB7 events in ERBB2 signaling	R-HSA-1306955	3.027794e-02	1.519
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	3.027794e-02	1.519
Signaling by MAP2K mutants	R-HSA-9652169	3.027794e-02	1.519
Signaling by GSK3beta mutants	R-HSA-5339716	3.081537e-02	1.511
Regulation of endogenous retroelements	R-HSA-9842860	3.377681e-02	1.471
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.166650e-02	1.499
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.262292e-02	1.486
NoRC negatively regulates rRNA expression	R-HSA-427413	2.805413e-02	1.552
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.262292e-02	1.486
Signaling by AXIN mutants	R-HSA-4839735	3.081537e-02	1.511
Signaling by AMER1 mutants	R-HSA-4839748	3.081537e-02	1.511
Cell Cycle	R-HSA-1640170	3.060437e-02	1.514
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.708026e-02	1.567
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.119200e-02	1.506
Signaling by WNT	R-HSA-195721	3.264746e-02	1.486
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	3.143836e-02	1.503
Signal Transduction	R-HSA-162582	3.164414e-02	1.500
Transcriptional regulation by RUNX1	R-HSA-8878171	3.180187e-02	1.498
Diseases of programmed cell death	R-HSA-9645723	3.322047e-02	1.479
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.968262e-02	1.527
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	3.146007e-02	1.502
SARS-CoV-2 Infection	R-HSA-9694516	2.967850e-02	1.528
SARS-CoV Infections	R-HSA-9679506	3.097322e-02	1.509
SARS-CoV-1 Infection	R-HSA-9678108	3.162456e-02	1.500
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.456187e-02	1.461
IRS activation	R-HSA-74713	4.003042e-02	1.398
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	3.621031e-02	1.441
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.621031e-02	1.441
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	3.621031e-02	1.441
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	3.621031e-02	1.441
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	3.621031e-02	1.441
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	3.621031e-02	1.441
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.903160e-02	1.409
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.570282e-02	1.447
p75NTR recruits signalling complexes	R-HSA-209543	3.621031e-02	1.441
RAF-independent MAPK1/3 activation	R-HSA-112409	3.863364e-02	1.413
Mitophagy	R-HSA-5205647	3.903160e-02	1.409
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.977955e-02	1.400
Signaling by TGFBR3	R-HSA-9839373	3.669460e-02	1.435
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	3.669460e-02	1.435
Cellular responses to stress	R-HSA-2262752	3.910531e-02	1.408
Nervous system development	R-HSA-9675108	3.651526e-02	1.438
Apoptotic execution phase	R-HSA-75153	3.669460e-02	1.435
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	4.104818e-02	1.387
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.107474e-02	1.386
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	4.384740e-02	1.358
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	4.384740e-02	1.358
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	4.384740e-02	1.358
Loss of Function of TP53 in Cancer	R-HSA-9723907	4.384740e-02	1.358
PRC2 methylates histones and DNA	R-HSA-212300	4.615573e-02	1.336
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	4.715882e-02	1.326
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.715882e-02	1.326
RET signaling	R-HSA-8853659	4.615573e-02	1.336
Interleukin-6 signaling	R-HSA-1059683	4.205653e-02	1.376
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.748293e-02	1.323
Oncogene Induced Senescence	R-HSA-2559585	4.250357e-02	1.372
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.205653e-02	1.376
Frs2-mediated activation	R-HSA-170968	4.205653e-02	1.376
Signalling to ERKs	R-HSA-187687	4.250357e-02	1.372
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	4.834534e-02	1.316
RUNX2 regulates bone development	R-HSA-8941326	4.615573e-02	1.336
Signaling by ROBO receptors	R-HSA-376176	4.596752e-02	1.338
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.998892e-02	1.301
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	5.079184e-02	1.294
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.079184e-02	1.294
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.079184e-02	1.294
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	5.155623e-02	1.288
MyD88-independent TLR4 cascade	R-HSA-166166	5.155623e-02	1.288
G2/M DNA replication checkpoint	R-HSA-69478	6.245523e-02	1.204
Beta-catenin phosphorylation cascade	R-HSA-196299	5.506612e-02	1.259
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.220665e-02	1.206
Nuclear signaling by ERBB4	R-HSA-1251985	6.257746e-02	1.204
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.257746e-02	1.204
mRNA Splicing - Major Pathway	R-HSA-72163	6.084961e-02	1.216
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	5.434741e-02	1.265
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	5.434741e-02	1.265
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	5.434741e-02	1.265
HDMs demethylate histones	R-HSA-3214842	5.242286e-02	1.280
p75NTR signals via NF-kB	R-HSA-193639	5.506612e-02	1.259
MET promotes cell motility	R-HSA-8875878	5.400359e-02	1.268
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.033343e-02	1.219
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.033343e-02	1.219
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.033343e-02	1.219
Long-term potentiation	R-HSA-9620244	5.242286e-02	1.280
NS1 Mediated Effects on Host Pathways	R-HSA-168276	5.819986e-02	1.235
Cellular responses to stimuli	R-HSA-8953897	5.679678e-02	1.246
SARS-CoV-2-host interactions	R-HSA-9705683	5.896347e-02	1.229
Interleukin-7 signaling	R-HSA-1266695	5.242286e-02	1.280
Unfolded Protein Response (UPR)	R-HSA-381119	5.222427e-02	1.282
Clathrin-mediated endocytosis	R-HSA-8856828	6.288504e-02	1.201
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	6.291643e-02	1.201
RNA Polymerase I Promoter Opening	R-HSA-73728	6.291643e-02	1.201
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	6.291643e-02	1.201
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	6.299970e-02	1.201
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	6.460777e-02	1.190
Influenza Infection	R-HSA-168255	6.663874e-02	1.176
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.713576e-02	1.173
Hedgehog 'on' state	R-HSA-5632684	6.810062e-02	1.167
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	6.854629e-02	1.164
Diseases of Telomere Maintenance	R-HSA-9673013	8.577476e-02	1.067
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	8.577476e-02	1.067
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	8.577476e-02	1.067
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	8.577476e-02	1.067
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	8.577476e-02	1.067
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	8.577476e-02	1.067
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	8.577476e-02	1.067
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	8.577476e-02	1.067
SOS-mediated signalling	R-HSA-112412	7.492104e-02	1.125
SHC1 events in ERBB4 signaling	R-HSA-1250347	6.975327e-02	1.156
Signaling by ERBB2 ECD mutants	R-HSA-9665348	8.600446e-02	1.065
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	7.442679e-02	1.128
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.055360e-02	1.094
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	8.055360e-02	1.094
HIV Transcription Initiation	R-HSA-167161	7.187380e-02	1.143
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.187380e-02	1.143
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	7.541980e-02	1.123
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	8.460501e-02	1.073
mRNA Splicing	R-HSA-72172	8.426818e-02	1.074
Peptide chain elongation	R-HSA-156902	7.407814e-02	1.130
Eukaryotic Translation Initiation	R-HSA-72613	7.182955e-02	1.144
Regulation of TP53 Activity through Methylation	R-HSA-6804760	8.600446e-02	1.065
Cap-dependent Translation Initiation	R-HSA-72737	7.182955e-02	1.144
RNA Polymerase II Promoter Escape	R-HSA-73776	8.188362e-02	1.087
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.187380e-02	1.143
Circadian clock	R-HSA-9909396	7.376083e-02	1.132
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.056569e-02	1.094
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.056569e-02	1.094
MAPK1/MAPK3 signaling	R-HSA-5684996	8.151697e-02	1.089
Transcriptional regulation by small RNAs	R-HSA-5578749	7.170463e-02	1.144
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	7.804009e-02	1.108
Signaling by Hippo	R-HSA-2028269	7.769114e-02	1.110
Disorders of Developmental Biology	R-HSA-9675151	6.975327e-02	1.156
Displacement of DNA glycosylase by APEX1	R-HSA-110357	7.492104e-02	1.125
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.055360e-02	1.094
ISG15 antiviral mechanism	R-HSA-1169408	8.318298e-02	1.080
MET receptor recycling	R-HSA-8875656	8.809669e-02	1.055
Formation of annular gap junctions	R-HSA-196025	8.809669e-02	1.055
Gap junction degradation	R-HSA-190873	1.018962e-01	0.992
MAPK1 (ERK2) activation	R-HSA-112411	1.018962e-01	0.992
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.036903e-01	0.984
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	8.692183e-02	1.061
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	8.692183e-02	1.061
G0 and Early G1	R-HSA-1538133	9.352610e-02	1.029
IPs transport between nucleus and cytosol	R-HSA-1855170	1.003605e-01	0.998
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.003605e-01	0.998
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.074188e-01	0.969
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.074188e-01	0.969
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	1.074188e-01	0.969
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.137972e-01	0.944
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.039963e-01	0.983
Formation of a pool of free 40S subunits	R-HSA-72689	1.081481e-01	0.966
Condensation of Prophase Chromosomes	R-HSA-2299718	9.820391e-02	1.008
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.259279e-02	1.033
GP1b-IX-V activation signalling	R-HSA-430116	1.018962e-01	0.992
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	1.039824e-01	0.983
Calcineurin activates NFAT	R-HSA-2025928	1.018962e-01	0.992
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	1.130278e-01	0.947
RAF activation	R-HSA-5673000	1.146943e-01	0.940
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	8.849533e-02	1.053
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	8.849533e-02	1.053
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	8.849533e-02	1.053
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	8.849533e-02	1.053
Signaling by WNT in cancer	R-HSA-4791275	9.352610e-02	1.029
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.992823e-02	1.046
Eukaryotic Translation Termination	R-HSA-72764	1.081481e-01	0.966
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.992823e-02	1.046
M Phase	R-HSA-68886	1.013760e-01	0.994
Recycling pathway of L1	R-HSA-437239	1.039824e-01	0.983
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.498062e-02	1.022
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.860676e-02	1.006
RMTs methylate histone arginines	R-HSA-3214858	8.715186e-02	1.060
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.993498e-02	1.000
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	1.138957e-01	0.943
Signaling by NOTCH1 in Cancer	R-HSA-2644603	8.849533e-02	1.053
Eukaryotic Translation Elongation	R-HSA-156842	9.208604e-02	1.036
Signaling by NOTCH1	R-HSA-1980143	8.723036e-02	1.059
Regulation of signaling by CBL	R-HSA-912631	9.467661e-02	1.024
RAF/MAP kinase cascade	R-HSA-5673001	1.073204e-01	0.969
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.352610e-02	1.029
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.074188e-01	0.969
Heme signaling	R-HSA-9707616	9.807902e-02	1.008
G1/S DNA Damage Checkpoints	R-HSA-69615	1.030693e-01	0.987
MAPK family signaling cascades	R-HSA-5683057	1.074433e-01	0.969
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.102402e-01	0.958
Nuclear import of Rev protein	R-HSA-180746	1.146943e-01	0.940
Influenza Viral RNA Transcription and Replication	R-HSA-168273	9.401671e-02	1.027
Signal transduction by L1	R-HSA-445144	1.036903e-01	0.984
Signaling by TGFB family members	R-HSA-9006936	1.093446e-01	0.961
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.003605e-01	0.998
Late Phase of HIV Life Cycle	R-HSA-162599	1.102402e-01	0.958
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.018962e-01	0.992
Death Receptor Signaling	R-HSA-73887	9.111781e-02	1.040
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	9.111781e-02	1.040
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.134388e-01	0.945
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.160294e-01	0.935
MAPK3 (ERK1) activation	R-HSA-110056	1.162396e-01	0.935
PI3K/AKT activation	R-HSA-198203	1.162396e-01	0.935
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	1.162396e-01	0.935
Signal attenuation	R-HSA-74749	1.162396e-01	0.935
Defective VWF binding to collagen type I	R-HSA-9845622	1.258660e-01	0.900
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	1.258660e-01	0.900
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	1.258660e-01	0.900
IKBKB deficiency causes SCID	R-HSA-5602636	1.258660e-01	0.900
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.642015e-01	0.785
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.642015e-01	0.785
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.642015e-01	0.785
Defective PAPSS2 causes SEMD-PA	R-HSA-3560796	1.642015e-01	0.785
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.642015e-01	0.785
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.642015e-01	0.785
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.642015e-01	0.785
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	1.642015e-01	0.785
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.642015e-01	0.785
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.642015e-01	0.785
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.642015e-01	0.785
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	1.642015e-01	0.785
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.642015e-01	0.785
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.642015e-01	0.785
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.642015e-01	0.785
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.310529e-01	0.883
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	1.462675e-01	0.835
PI3K events in ERBB4 signaling	R-HSA-1250342	1.462675e-01	0.835
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.618198e-01	0.791
IRAK1 recruits IKK complex	R-HSA-937039	1.618198e-01	0.791
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.618198e-01	0.791
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	1.226710e-01	0.911
Notch-HLH transcription pathway	R-HSA-350054	1.326014e-01	0.877
Deadenylation of mRNA	R-HSA-429947	1.532503e-01	0.815
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.221799e-01	0.913
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	1.298682e-01	0.886
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.540723e-01	0.812
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.624931e-01	0.789
mRNA 3'-end processing	R-HSA-72187	1.352720e-01	0.869
Signaling by ERBB4	R-HSA-1236394	1.661004e-01	0.780
Viral mRNA Translation	R-HSA-192823	1.445246e-01	0.840
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.748266e-01	0.757
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.388145e-01	0.858
RNA Polymerase III Transcription	R-HSA-74158	1.298682e-01	0.886
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.326014e-01	0.877
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.226710e-01	0.911
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	1.326014e-01	0.877
Cyclin E associated events during G1/S transition	R-HSA-69202	1.415391e-01	0.849
G2/M DNA damage checkpoint	R-HSA-69473	1.661004e-01	0.780
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.618198e-01	0.791
Transcriptional Regulation by TP53	R-HSA-3700989	1.527686e-01	0.816
Interleukin-1 signaling	R-HSA-9020702	1.349167e-01	0.870
Adipogenesis	R-HSA-9843745	1.295737e-01	0.887
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	1.326014e-01	0.877
SWI/SNF chromatin remodelers	R-HSA-9932451	1.639317e-01	0.785
ATP-dependent chromatin remodelers	R-HSA-9932444	1.639317e-01	0.785
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.748266e-01	0.757
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.710764e-01	0.767
Meiosis	R-HSA-1500620	1.285051e-01	0.891
Interleukin-6 family signaling	R-HSA-6783589	1.532503e-01	0.815
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.662558e-01	0.779
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	1.258660e-01	0.900
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	1.258660e-01	0.900
NF-kB is activated and signals survival	R-HSA-209560	1.462675e-01	0.835
VLDLR internalisation and degradation	R-HSA-8866427	1.618198e-01	0.791
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.428007e-01	0.845
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.377517e-01	0.861
Meiotic recombination	R-HSA-912446	1.287065e-01	0.890
Cellular response to starvation	R-HSA-9711097	1.723423e-01	0.764
Autophagy	R-HSA-9612973	1.637869e-01	0.786
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.540723e-01	0.812
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.261730e-01	0.899
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.536010e-01	0.814
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.618198e-01	0.791
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.494519e-01	0.825
Transcriptional Regulation by VENTX	R-HSA-8853884	1.710764e-01	0.767
Toll-like Receptor Cascades	R-HSA-168898	1.551228e-01	0.809
Protein-protein interactions at synapses	R-HSA-6794362	1.285051e-01	0.891
RHOBTB3 ATPase cycle	R-HSA-9706019	1.310529e-01	0.883
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.326014e-01	0.877
Metalloprotease DUBs	R-HSA-5689901	1.748266e-01	0.757
Transcriptional Regulation by E2F6	R-HSA-8953750	1.540723e-01	0.812
Signaling by NOTCH	R-HSA-157118	1.300679e-01	0.886
Sema4D in semaphorin signaling	R-HSA-400685	1.639317e-01	0.785
p75 NTR receptor-mediated signalling	R-HSA-193704	1.256459e-01	0.901
Selenocysteine synthesis	R-HSA-2408557	1.349167e-01	0.870
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.669702e-01	0.777
Activation of RAC1	R-HSA-428540	1.462675e-01	0.835
Interactions of Rev with host cellular proteins	R-HSA-177243	1.624931e-01	0.789
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.624931e-01	0.789
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.710764e-01	0.767
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.536010e-01	0.814
HIV Infection	R-HSA-162906	1.497550e-01	0.825
Pervasive developmental disorders	R-HSA-9005895	1.618198e-01	0.791
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.618198e-01	0.791
Disorders of Nervous System Development	R-HSA-9697154	1.618198e-01	0.791
LDL clearance	R-HSA-8964038	1.326014e-01	0.877
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.458224e-01	0.836
Interleukin-12 family signaling	R-HSA-447115	1.441158e-01	0.841
Neurodegenerative Diseases	R-HSA-8863678	1.532503e-01	0.815
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.532503e-01	0.815
HIV Life Cycle	R-HSA-162587	1.680378e-01	0.775
Viral Infection Pathways	R-HSA-9824446	1.547040e-01	0.810
Transcriptional Regulation by MECP2	R-HSA-8986944	1.662558e-01	0.779
Mitochondrial calcium ion transport	R-HSA-8949215	1.226710e-01	0.911
Gene Silencing by RNA	R-HSA-211000	1.699523e-01	0.770
Growth hormone receptor signaling	R-HSA-982772	1.428007e-01	0.845
MET activates PTPN11	R-HSA-8865999	2.008580e-01	0.697
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	2.008580e-01	0.697
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.008580e-01	0.697
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.008580e-01	0.697
MTF1 activates gene expression	R-HSA-5660489	2.359090e-01	0.627
HCN channels	R-HSA-1296061	2.359090e-01	0.627
Nucleotide catabolism defects	R-HSA-9735786	2.359090e-01	0.627
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.359090e-01	0.627
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.359090e-01	0.627
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	2.359090e-01	0.627
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	2.359090e-01	0.627
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	2.359090e-01	0.627
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.694246e-01	0.570
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.694246e-01	0.570
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	2.694246e-01	0.570
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	2.694246e-01	0.570
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	3.014720e-01	0.521
Nef Mediated CD8 Down-regulation	R-HSA-182218	3.014720e-01	0.521
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	3.014720e-01	0.521
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	3.014720e-01	0.521
Noncanonical activation of NOTCH3	R-HSA-9017802	3.014720e-01	0.521
PTK6 Regulates Cell Cycle	R-HSA-8849470	3.014720e-01	0.521
Signaling by MAPK mutants	R-HSA-9652817	3.014720e-01	0.521
Signaling by RNF43 mutants	R-HSA-5340588	3.014720e-01	0.521
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	1.776511e-01	0.750
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.776511e-01	0.750
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.776511e-01	0.750
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.776511e-01	0.750
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.321156e-01	0.479
Erythropoietin activates STAT5	R-HSA-9027283	3.321156e-01	0.479
Erythropoietin activates RAS	R-HSA-9027284	2.099376e-01	0.678
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.099376e-01	0.678
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.592347e-01	0.586
GAB1 signalosome	R-HSA-180292	2.757387e-01	0.560
Ephrin signaling	R-HSA-3928664	2.757387e-01	0.560
RNA Polymerase III Transcription Termination	R-HSA-73980	2.757387e-01	0.560
Signaling by Erythropoietin	R-HSA-9006335	2.086118e-01	0.681
DNA methylation	R-HSA-5334118	2.086118e-01	0.681
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.086533e-01	0.511
Diseases of mitotic cell cycle	R-HSA-9675126	2.436828e-01	0.613
RNA Polymerase I Promoter Escape	R-HSA-73772	2.836167e-01	0.547
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.653525e-01	0.576
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.523841e-01	0.453
Nuclear Receptor transcription pathway	R-HSA-383280	3.429651e-01	0.465
HCMV Early Events	R-HSA-9609690	2.620831e-01	0.582
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	3.342148e-01	0.476
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	1.775736e-01	0.751
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	3.250069e-01	0.488
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	3.250069e-01	0.488
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.592347e-01	0.586
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.592347e-01	0.586
Signaling by EGFR	R-HSA-177929	3.235066e-01	0.490
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.776511e-01	0.750
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	3.086533e-01	0.511
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	3.432565e-01	0.464
Ribosome-associated quality control	R-HSA-9948299	2.637065e-01	0.579
RIPK1-mediated regulated necrosis	R-HSA-5213460	3.281036e-01	0.484
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.427421e-01	0.615
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.427421e-01	0.615
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.082834e-01	0.681
Transcriptional regulation of testis differentiation	R-HSA-9690406	2.427421e-01	0.615
RNA Polymerase III Transcription Initiation	R-HSA-76046	2.201819e-01	0.657
EPH-Ephrin signaling	R-HSA-2682334	3.094068e-01	0.509
Regulation of necroptotic cell death	R-HSA-5675482	2.555814e-01	0.592
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.099376e-01	0.678
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.427421e-01	0.615
Regulation of NF-kappa B signaling	R-HSA-9758274	2.262968e-01	0.645
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.349870e-01	0.629
Post-transcriptional silencing by small RNAs	R-HSA-426496	2.694246e-01	0.570
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	2.099376e-01	0.678
Activation of SMO	R-HSA-5635838	2.262968e-01	0.645
IKK complex recruitment mediated by RIP1	R-HSA-937041	2.922215e-01	0.534
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.161301e-01	0.665
Lysosome Vesicle Biogenesis	R-HSA-432720	3.038079e-01	0.517
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.359090e-01	0.627
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.359090e-01	0.627
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	2.359090e-01	0.627
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.099376e-01	0.678
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	2.592347e-01	0.586
SIRT1 negatively regulates rRNA expression	R-HSA-427359	3.159516e-01	0.500
Selective autophagy	R-HSA-9663891	2.712051e-01	0.567
Hedgehog 'off' state	R-HSA-5610787	2.339210e-01	0.631
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	1.937070e-01	0.713
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.427537e-01	0.615
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.175249e-01	0.498
Nuclear RNA decay	R-HSA-9930044	2.555814e-01	0.592
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.262968e-01	0.645
Neurexins and neuroligins	R-HSA-6794361	2.836167e-01	0.547
Signaling by Hedgehog	R-HSA-5358351	2.637065e-01	0.579
Cell Cycle Checkpoints	R-HSA-69620	2.702245e-01	0.568
MET interacts with TNS proteins	R-HSA-8875513	2.008580e-01	0.697
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	2.694246e-01	0.570
Reelin signalling pathway	R-HSA-8866376	2.694246e-01	0.570
IkBA variant leads to EDA-ID	R-HSA-5603029	3.014720e-01	0.521
Sensory perception of salty taste	R-HSA-9730628	3.014720e-01	0.521
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.757387e-01	0.560
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.161301e-01	0.665
RNA Polymerase II Transcription Termination	R-HSA-73856	2.003837e-01	0.698
Deadenylation-dependent mRNA decay	R-HSA-429914	3.536740e-01	0.451
Macroautophagy	R-HSA-1632852	1.771554e-01	0.752
Cyclin D associated events in G1	R-HSA-69231	2.068633e-01	0.684
G1 Phase	R-HSA-69236	2.068633e-01	0.684
G2/M Transition	R-HSA-69275	2.147773e-01	0.668
Mitotic G2-G2/M phases	R-HSA-453274	2.239396e-01	0.650
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.201819e-01	0.657
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	3.086533e-01	0.511
Pre-NOTCH Expression and Processing	R-HSA-1912422	3.302169e-01	0.481
Evasion by RSV of host interferon responses	R-HSA-9833109	2.318777e-01	0.635
Negative regulation of MAPK pathway	R-HSA-5675221	1.798137e-01	0.745
Interleukin-1 family signaling	R-HSA-446652	2.368820e-01	0.625
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.359090e-01	0.627
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.262968e-01	0.645
Regulation of TP53 Degradation	R-HSA-6804757	3.038079e-01	0.517
G1/S Transition	R-HSA-69206	1.818054e-01	0.740
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.081997e-01	0.682
Metabolism of RNA	R-HSA-8953854	2.961206e-01	0.529
Amine ligand-binding receptors	R-HSA-375280	2.068633e-01	0.684
ESR-mediated signaling	R-HSA-8939211	2.680604e-01	0.572
Prolactin receptor signaling	R-HSA-1170546	1.937070e-01	0.713
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	3.523841e-01	0.453
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	3.523841e-01	0.453
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	2.359090e-01	0.627
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	2.359090e-01	0.627
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	1.937070e-01	0.713
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	3.321156e-01	0.479
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	2.592347e-01	0.586
Defective pyroptosis	R-HSA-9710421	1.977158e-01	0.704
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	3.250069e-01	0.488
Signaling by MET	R-HSA-6806834	2.059799e-01	0.686
snRNP Assembly	R-HSA-191859	3.536740e-01	0.451
Metabolism of non-coding RNA	R-HSA-194441	3.536740e-01	0.451
Host Interactions of HIV factors	R-HSA-162909	2.817041e-01	0.550
Histamine receptors	R-HSA-390650	2.008580e-01	0.697
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.321156e-01	0.479
Regulation of MECP2 expression and activity	R-HSA-9022692	2.555814e-01	0.592
tRNA processing in the nucleus	R-HSA-6784531	2.081997e-01	0.682
NRAGE signals death through JNK	R-HSA-193648	3.235066e-01	0.490
Ub-specific processing proteases	R-HSA-5689880	2.477944e-01	0.606
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	2.757387e-01	0.560
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	2.161301e-01	0.665
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	2.161301e-01	0.665
NGF-stimulated transcription	R-HSA-9031628	2.445599e-01	0.612
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.145921e-01	0.668
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.436828e-01	0.613
Transcription of the HIV genome	R-HSA-167172	2.569634e-01	0.590
S Phase	R-HSA-69242	3.298011e-01	0.482
Relaxin receptors	R-HSA-444821	3.014720e-01	0.521
PI5P Regulates TP53 Acetylation	R-HSA-6811555	1.776511e-01	0.750
CREB phosphorylation	R-HSA-199920	3.321156e-01	0.479
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.086118e-01	0.681
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	3.250069e-01	0.488
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	2.795973e-01	0.553
Zygotic genome activation (ZGA)	R-HSA-9819196	3.250069e-01	0.488
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	2.994636e-01	0.524
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.261926e-01	0.646
Maturation of nucleoprotein	R-HSA-9683610	1.776511e-01	0.750
NOD1/2 Signaling Pathway	R-HSA-168638	2.795973e-01	0.553
Semaphorin interactions	R-HSA-373755	2.161135e-01	0.665
Ovarian tumor domain proteases	R-HSA-5689896	3.159516e-01	0.500
Signaling by VEGF	R-HSA-194138	2.945143e-01	0.531
L1CAM interactions	R-HSA-373760	2.321603e-01	0.634
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.694246e-01	0.570
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	3.014720e-01	0.521
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	3.014720e-01	0.521
Nef and signal transduction	R-HSA-164944	3.321156e-01	0.479
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.255075e-01	0.647
Negative regulation of the PI3K/AKT network	R-HSA-199418	2.077703e-01	0.682
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.477944e-01	0.606
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.477944e-01	0.606
Plasma lipoprotein clearance	R-HSA-8964043	3.402517e-01	0.468
Downstream signal transduction	R-HSA-186763	2.318777e-01	0.635
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.099376e-01	0.678
Assembly of the ORC complex at the origin of replication	R-HSA-68616	2.555814e-01	0.592
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.081041e-01	0.511
Glycolysis	R-HSA-70171	2.339210e-01	0.631
Cellular response to heat stress	R-HSA-3371556	2.627806e-01	0.580
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	3.014720e-01	0.521
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	3.014720e-01	0.521
Physiological factors	R-HSA-5578768	1.937070e-01	0.713
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.262968e-01	0.645
Creatine metabolism	R-HSA-71288	3.086533e-01	0.511
Transcriptional regulation by RUNX2	R-HSA-8878166	2.503843e-01	0.601
Regulation of beta-cell development	R-HSA-186712	3.536740e-01	0.451
Selenoamino acid metabolism	R-HSA-2408522	3.028373e-01	0.519
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	2.694246e-01	0.570
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.014720e-01	0.521
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.099376e-01	0.678
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	1.776511e-01	0.750
TNF signaling	R-HSA-75893	3.235066e-01	0.490
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.926706e-01	0.715
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.250069e-01	0.488
Translation of Structural Proteins	R-HSA-9694635	1.856176e-01	0.731
Replication of the SARS-CoV-1 genome	R-HSA-9682706	1.776511e-01	0.750
Signaling by ALK	R-HSA-201556	3.402517e-01	0.468
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	2.129395e-01	0.672
Replication of the SARS-CoV-2 genome	R-HSA-9694686	2.592347e-01	0.586
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	1.937070e-01	0.713
Uptake and actions of bacterial toxins	R-HSA-5339562	2.836167e-01	0.547
Late SARS-CoV-2 Infection Events	R-HSA-9772573	3.094068e-01	0.509
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	2.922215e-01	0.534
Interleukin-12 signaling	R-HSA-9020591	1.790136e-01	0.747
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	3.573831e-01	0.447
MET activates PI3K/AKT signaling	R-HSA-8851907	3.614166e-01	0.442
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	3.614166e-01	0.442
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	3.614166e-01	0.442
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	3.614166e-01	0.442
Nef Mediated CD4 Down-regulation	R-HSA-167590	3.614166e-01	0.442
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	3.614166e-01	0.442
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.614166e-01	0.442
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.614166e-01	0.442
VLDL clearance	R-HSA-8964046	3.614166e-01	0.442
TRIF-mediated programmed cell death	R-HSA-2562578	3.614166e-01	0.442
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	3.614166e-01	0.442
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	3.644895e-01	0.438
Amyloid fiber formation	R-HSA-977225	3.692890e-01	0.433
Mitotic Anaphase	R-HSA-68882	3.705249e-01	0.431
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	3.716932e-01	0.430
FOXO-mediated transcription	R-HSA-9614085	3.720678e-01	0.429
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	3.726611e-01	0.429
Glucose metabolism	R-HSA-70326	3.733139e-01	0.428
Viral Messenger RNA Synthesis	R-HSA-168325	3.737975e-01	0.427
Signaling by Interleukins	R-HSA-449147	3.753364e-01	0.426
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.758757e-01	0.425
Degradation of GLI1 by the proteasome	R-HSA-5610780	3.765572e-01	0.424
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	3.765572e-01	0.424
Degradation of GLI2 by the proteasome	R-HSA-5610783	3.765572e-01	0.424
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	3.838429e-01	0.416
HCMV Late Events	R-HSA-9610379	3.858991e-01	0.414
Cleavage of the damaged pyrimidine	R-HSA-110329	3.885772e-01	0.411
Depyrimidination	R-HSA-73928	3.885772e-01	0.411
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	3.885772e-01	0.411
TRAF6 mediated NF-kB activation	R-HSA-933542	3.891790e-01	0.410
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.891790e-01	0.410
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	3.891790e-01	0.410
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.891790e-01	0.410
Type I hemidesmosome assembly	R-HSA-446107	3.894338e-01	0.410
EGFR interacts with phospholipase C-gamma	R-HSA-212718	3.894338e-01	0.410
Activated NTRK2 signals through PI3K	R-HSA-9028335	3.894338e-01	0.410
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.894338e-01	0.410
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.894338e-01	0.410
FGFR1b ligand binding and activation	R-HSA-190370	3.894338e-01	0.410
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	3.894338e-01	0.410
Co-inhibition by PD-1	R-HSA-389948	3.941911e-01	0.404
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.957483e-01	0.403
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.957483e-01	0.403
TBC/RABGAPs	R-HSA-8854214	4.005398e-01	0.397
Response of Mtb to phagocytosis	R-HSA-9637690	4.005398e-01	0.397
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	4.162234e-01	0.381
ARMS-mediated activation	R-HSA-170984	4.162234e-01	0.381
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	4.162234e-01	0.381
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.162234e-01	0.381
Regulation of signaling by NODAL	R-HSA-1433617	4.162234e-01	0.381
WNT mediated activation of DVL	R-HSA-201688	4.162234e-01	0.381
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	4.162234e-01	0.381
Regulation of CDH11 gene transcription	R-HSA-9762293	4.162234e-01	0.381
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.162234e-01	0.381
MHC class II antigen presentation	R-HSA-2132295	4.166834e-01	0.380
Signaling by EGFR in Cancer	R-HSA-1643713	4.202561e-01	0.376
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	4.202561e-01	0.376
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	4.202561e-01	0.376
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.202561e-01	0.376
Myogenesis	R-HSA-525793	4.202561e-01	0.376
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	4.202561e-01	0.376
Programmed Cell Death	R-HSA-5357801	4.280671e-01	0.368
Post NMDA receptor activation events	R-HSA-438064	4.305667e-01	0.366
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.354895e-01	0.361
Signaling by BMP	R-HSA-201451	4.354895e-01	0.361
mRNA Splicing - Minor Pathway	R-HSA-72165	4.359949e-01	0.361
Regulation of TNFR1 signaling	R-HSA-5357905	4.359949e-01	0.361
HCMV Infection	R-HSA-9609646	4.362352e-01	0.360
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.418392e-01	0.355
Folding of actin by CCT/TriC	R-HSA-390450	4.418392e-01	0.355
EGFR Transactivation by Gastrin	R-HSA-2179392	4.418392e-01	0.355
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	4.418392e-01	0.355
Josephin domain DUBs	R-HSA-5689877	4.418392e-01	0.355
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.418392e-01	0.355
Interleukin-27 signaling	R-HSA-9020956	4.418392e-01	0.355
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	4.418392e-01	0.355
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	4.418392e-01	0.355
Pexophagy	R-HSA-9664873	4.418392e-01	0.355
Receptor Mediated Mitophagy	R-HSA-8934903	4.418392e-01	0.355
Regulated Necrosis	R-HSA-5218859	4.435062e-01	0.353
rRNA processing in the nucleus and cytosol	R-HSA-8868773	4.498162e-01	0.347
Pyrimidine salvage	R-HSA-73614	4.505037e-01	0.346
G2/M Checkpoints	R-HSA-69481	4.526527e-01	0.344
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	4.591913e-01	0.338
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.591913e-01	0.338
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.630314e-01	0.334
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	4.630314e-01	0.334
Late endosomal microautophagy	R-HSA-9615710	4.652887e-01	0.332
Impaired BRCA2 binding to RAD51	R-HSA-9709570	4.652887e-01	0.332
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.652887e-01	0.332
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	4.663324e-01	0.331
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	4.663324e-01	0.331
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	4.663324e-01	0.331
Cell junction organization	R-HSA-446728	4.669720e-01	0.331
Regulation of T cell activation by CD28 family	R-HSA-388841	4.671891e-01	0.331
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	4.727040e-01	0.325
Mitotic Prometaphase	R-HSA-68877	4.792989e-01	0.319
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	4.798355e-01	0.319
Activation of BH3-only proteins	R-HSA-114452	4.798355e-01	0.319
Interleukin-37 signaling	R-HSA-9008059	4.798355e-01	0.319
Reproduction	R-HSA-1474165	4.811146e-01	0.318
Inositol phosphate metabolism	R-HSA-1483249	4.816554e-01	0.317
PI3K Cascade	R-HSA-109704	4.819702e-01	0.317
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.823107e-01	0.317
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.823107e-01	0.317
trans-Golgi Network Vesicle Budding	R-HSA-199992	4.823107e-01	0.317
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.897523e-01	0.310
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	4.897523e-01	0.310
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	4.897523e-01	0.310
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	4.897523e-01	0.310
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	4.897523e-01	0.310
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.897523e-01	0.310
Plasmalogen biosynthesis	R-HSA-75896	4.897523e-01	0.310
Anchoring fibril formation	R-HSA-2214320	4.897523e-01	0.310
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.897523e-01	0.310
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.918474e-01	0.308
EGFR downregulation	R-HSA-182971	4.941367e-01	0.306
Budding and maturation of HIV virion	R-HSA-162588	4.941367e-01	0.306
Adherens junctions interactions	R-HSA-418990	5.009219e-01	0.300
Signaling by NOTCH4	R-HSA-9013694	5.013103e-01	0.300
Centrosome maturation	R-HSA-380287	5.106956e-01	0.292
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	5.121457e-01	0.291
RUNX3 regulates p14-ARF	R-HSA-8951936	5.121457e-01	0.291
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.121457e-01	0.291
GRB2 events in EGFR signaling	R-HSA-179812	5.121457e-01	0.291
Interleukin-35 Signalling	R-HSA-8984722	5.121457e-01	0.291
Signaling by LTK	R-HSA-9842663	5.121457e-01	0.291
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.121457e-01	0.291
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.121457e-01	0.291
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	5.121457e-01	0.291
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	5.121457e-01	0.291
OAS antiviral response	R-HSA-8983711	5.121457e-01	0.291
Golgi Associated Vesicle Biogenesis	R-HSA-432722	5.152530e-01	0.288
Meiotic synapsis	R-HSA-1221632	5.152530e-01	0.288
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.219775e-01	0.282
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	5.219775e-01	0.282
Integrin signaling	R-HSA-354192	5.219775e-01	0.282
Activation of ATR in response to replication stress	R-HSA-176187	5.219775e-01	0.282
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.219775e-01	0.282
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	5.219775e-01	0.282
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	5.260533e-01	0.279
Base-Excision Repair, AP Site Formation	R-HSA-73929	5.260910e-01	0.279
Transcriptional regulation by RUNX3	R-HSA-8878159	5.319309e-01	0.274
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	5.335576e-01	0.273
Adenylate cyclase activating pathway	R-HSA-170660	5.335576e-01	0.273
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.335576e-01	0.273
Platelet Adhesion to exposed collagen	R-HSA-75892	5.335576e-01	0.273
Membrane binding and targetting of GAG proteins	R-HSA-174490	5.335576e-01	0.273
Diseases of nucleotide metabolism	R-HSA-9735804	5.335576e-01	0.273
FGFR1c ligand binding and activation	R-HSA-190373	5.335576e-01	0.273
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	5.335576e-01	0.273
CD28 dependent Vav1 pathway	R-HSA-389359	5.335576e-01	0.273
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	5.335576e-01	0.273
Rab regulation of trafficking	R-HSA-9007101	5.343888e-01	0.272
Mitochondrial biogenesis	R-HSA-1592230	5.343888e-01	0.272
PCP/CE pathway	R-HSA-4086400	5.383522e-01	0.269
G alpha (12/13) signalling events	R-HSA-416482	5.383522e-01	0.269
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	5.473944e-01	0.262
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	5.473944e-01	0.262
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	5.487714e-01	0.261
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	5.487714e-01	0.261
Signaling by NOTCH2	R-HSA-1980145	5.487714e-01	0.261
Signaling by Nuclear Receptors	R-HSA-9006931	5.501127e-01	0.260
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.540311e-01	0.256
cGMP effects	R-HSA-418457	5.540311e-01	0.256
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.540311e-01	0.256
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.540311e-01	0.256
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.540311e-01	0.256
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	5.540311e-01	0.256
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	5.540311e-01	0.256
NRIF signals cell death from the nucleus	R-HSA-205043	5.540311e-01	0.256
Signaling by FGFR4 in disease	R-HSA-5655291	5.540311e-01	0.256
CRMPs in Sema3A signaling	R-HSA-399956	5.540311e-01	0.256
Malate-aspartate shuttle	R-HSA-9856872	5.540311e-01	0.256
HDL assembly	R-HSA-8963896	5.540311e-01	0.256
P2Y receptors	R-HSA-417957	5.540311e-01	0.256
PKR-mediated signaling	R-HSA-9833482	5.563434e-01	0.255
Cell-cell junction organization	R-HSA-421270	5.566236e-01	0.254
Apoptosis	R-HSA-109581	5.576752e-01	0.254
IRS-mediated signalling	R-HSA-112399	5.577787e-01	0.254
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.617673e-01	0.250
PERK regulates gene expression	R-HSA-381042	5.617673e-01	0.250
Nuclear events mediated by NFE2L2	R-HSA-9759194	5.634868e-01	0.249
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	5.736070e-01	0.241
Adenylate cyclase inhibitory pathway	R-HSA-170670	5.736070e-01	0.241
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.736070e-01	0.241
SHC1 events in EGFR signaling	R-HSA-180336	5.736070e-01	0.241
RNA Polymerase III Chain Elongation	R-HSA-73780	5.736070e-01	0.241
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	5.736070e-01	0.241
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.736070e-01	0.241
Transport and metabolism of PAPS	R-HSA-174362	5.736070e-01	0.241
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.736070e-01	0.241
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.736070e-01	0.241
p38MAPK events	R-HSA-171007	5.736070e-01	0.241
Protein methylation	R-HSA-8876725	5.736070e-01	0.241
Cell-extracellular matrix interactions	R-HSA-446353	5.736070e-01	0.241
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.739524e-01	0.241
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	5.781820e-01	0.238
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	5.781820e-01	0.238
Cytoprotection by HMOX1	R-HSA-9707564	5.826077e-01	0.235
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	5.869470e-01	0.231
TRAF6 mediated IRF7 activation	R-HSA-933541	5.869470e-01	0.231
Collagen chain trimerization	R-HSA-8948216	5.869470e-01	0.231
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.911609e-01	0.228
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	5.911609e-01	0.228
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	5.923249e-01	0.227
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	5.923249e-01	0.227
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	5.923249e-01	0.227
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.923249e-01	0.227
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	5.923249e-01	0.227
Regulation of BACH1 activity	R-HSA-9708530	5.923249e-01	0.227
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	5.923249e-01	0.227
Killing mechanisms	R-HSA-9664420	5.923249e-01	0.227
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.923249e-01	0.227
IRS-related events triggered by IGF1R	R-HSA-2428928	5.979831e-01	0.223
Collagen degradation	R-HSA-1442490	5.979831e-01	0.223
Nucleotide salvage	R-HSA-8956321	5.979831e-01	0.223
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	5.991288e-01	0.222
Membrane Trafficking	R-HSA-199991	5.995941e-01	0.222
Signaling by PDGF	R-HSA-186797	6.076528e-01	0.216
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	6.079535e-01	0.216
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	6.102221e-01	0.215
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.102221e-01	0.215
Passive transport by Aquaporins	R-HSA-432047	6.102221e-01	0.215
Fibronectin matrix formation	R-HSA-1566977	6.102221e-01	0.215
Galactose catabolism	R-HSA-70370	6.102221e-01	0.215
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	6.102221e-01	0.215
Response to metal ions	R-HSA-5660526	6.102221e-01	0.215
tRNA modification in the mitochondrion	R-HSA-6787450	6.102221e-01	0.215
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	6.110382e-01	0.214
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.161898e-01	0.210
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	6.171664e-01	0.210
Loss of Nlp from mitotic centrosomes	R-HSA-380259	6.171664e-01	0.210
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.171664e-01	0.210
Aggrephagy	R-HSA-9646399	6.226757e-01	0.206
Formation of Incision Complex in GG-NER	R-HSA-5696395	6.226757e-01	0.206
Diseases associated with the TLR signaling cascade	R-HSA-5602358	6.226757e-01	0.206
Diseases of Immune System	R-HSA-5260271	6.226757e-01	0.206
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.226757e-01	0.206
Chaperonin-mediated protein folding	R-HSA-390466	6.243175e-01	0.205
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.243697e-01	0.205
IGF1R signaling cascade	R-HSA-2428924	6.265226e-01	0.203
Insulin receptor signalling cascade	R-HSA-74751	6.265226e-01	0.203
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.265226e-01	0.203
Regulation of FZD by ubiquitination	R-HSA-4641263	6.273347e-01	0.203
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	6.273347e-01	0.203
Regulation of NPAS4 gene expression	R-HSA-9768759	6.273347e-01	0.203
Potential therapeutics for SARS	R-HSA-9679191	6.273677e-01	0.202
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	6.323353e-01	0.199
KEAP1-NFE2L2 pathway	R-HSA-9755511	6.334580e-01	0.198
VEGFR2 mediated vascular permeability	R-HSA-5218920	6.340421e-01	0.198
Maturation of spike protein	R-HSA-9694548	6.340421e-01	0.198
Resolution of Abasic Sites (AP sites)	R-HSA-73933	6.340421e-01	0.198
Cellular response to hypoxia	R-HSA-1234174	6.357205e-01	0.197
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.357205e-01	0.197
Cellular response to chemical stress	R-HSA-9711123	6.397122e-01	0.194
Nephron development	R-HSA-9831926	6.436969e-01	0.191
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	6.436969e-01	0.191
PKA activation in glucagon signalling	R-HSA-164378	6.436969e-01	0.191
Chaperone Mediated Autophagy	R-HSA-9613829	6.436969e-01	0.191
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.436969e-01	0.191
FGFR1 ligand binding and activation	R-HSA-190242	6.436969e-01	0.191
PKA activation	R-HSA-163615	6.436969e-01	0.191
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.436969e-01	0.191
Synaptic adhesion-like molecules	R-HSA-8849932	6.436969e-01	0.191
Tie2 Signaling	R-HSA-210993	6.436969e-01	0.191
Nucleotide-like (purinergic) receptors	R-HSA-418038	6.436969e-01	0.191
AURKA Activation by TPX2	R-HSA-8854518	6.447592e-01	0.191
Cell-Cell communication	R-HSA-1500931	6.450389e-01	0.190
Signaling by FGFR1 in disease	R-HSA-5655302	6.451389e-01	0.190
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	6.451389e-01	0.190
Translation of Structural Proteins	R-HSA-9683701	6.451389e-01	0.190
DNA Double-Strand Break Repair	R-HSA-5693532	6.454674e-01	0.190
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.480373e-01	0.188
DNA Double Strand Break Response	R-HSA-5693606	6.536382e-01	0.185
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.559678e-01	0.183
PPARA activates gene expression	R-HSA-1989781	6.572439e-01	0.182
PI-3K cascade:FGFR3	R-HSA-5654710	6.593417e-01	0.181
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.593417e-01	0.181
Crosslinking of collagen fibrils	R-HSA-2243919	6.593417e-01	0.181
E2F mediated regulation of DNA replication	R-HSA-113510	6.593417e-01	0.181
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.593417e-01	0.181
Diseases of hemostasis	R-HSA-9671793	6.593417e-01	0.181
Rap1 signalling	R-HSA-392517	6.593417e-01	0.181
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	6.662478e-01	0.176
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	6.665309e-01	0.176
Protein folding	R-HSA-391251	6.707439e-01	0.173
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.707439e-01	0.173
Regulation of PD-L1(CD274) translation	R-HSA-9909620	6.743005e-01	0.171
PI-3K cascade:FGFR4	R-HSA-5654720	6.743005e-01	0.171
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.743005e-01	0.171
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.743005e-01	0.171
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.743005e-01	0.171
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.743005e-01	0.171
Wax and plasmalogen biosynthesis	R-HSA-8848584	6.743005e-01	0.171
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	6.743005e-01	0.171
Signaling by NODAL	R-HSA-1181150	6.743005e-01	0.171
Negative regulation of MET activity	R-HSA-6807004	6.743005e-01	0.171
Common Pathway of Fibrin Clot Formation	R-HSA-140875	6.743005e-01	0.171
Protein hydroxylation	R-HSA-9629569	6.743005e-01	0.171
Glycogen synthesis	R-HSA-3322077	6.743005e-01	0.171
Gap junction trafficking	R-HSA-190828	6.768307e-01	0.170
Surfactant metabolism	R-HSA-5683826	6.768307e-01	0.170
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	6.793145e-01	0.168
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.795088e-01	0.168
Beta-catenin independent WNT signaling	R-HSA-3858494	6.822298e-01	0.166
Asymmetric localization of PCP proteins	R-HSA-4608870	6.868699e-01	0.163
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	6.868699e-01	0.163
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	6.881691e-01	0.162
MyD88 deficiency (TLR2/4)	R-HSA-5602498	6.886033e-01	0.162
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	6.886033e-01	0.162
ERK/MAPK targets	R-HSA-198753	6.886033e-01	0.162
PKA-mediated phosphorylation of CREB	R-HSA-111931	6.886033e-01	0.162
Basigin interactions	R-HSA-210991	6.886033e-01	0.162
Signalling to RAS	R-HSA-167044	6.886033e-01	0.162
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	6.886033e-01	0.162
rRNA processing	R-HSA-72312	6.928731e-01	0.159
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.966516e-01	0.157
Diseases of DNA repair	R-HSA-9675135	6.966516e-01	0.157
Cytokine Signaling in Immune system	R-HSA-1280215	6.971182e-01	0.157
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	7.022788e-01	0.153
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	7.022788e-01	0.153
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.022788e-01	0.153
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	7.022788e-01	0.153
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.022788e-01	0.153
Assembly Of The HIV Virion	R-HSA-175474	7.022788e-01	0.153
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.022788e-01	0.153
Signaling by PDGFR in disease	R-HSA-9671555	7.022788e-01	0.153
Ribavirin ADME	R-HSA-9755088	7.022788e-01	0.153
Homology Directed Repair	R-HSA-5693538	7.049583e-01	0.152
FCGR3A-mediated phagocytosis	R-HSA-9664422	7.055458e-01	0.151
Parasite infection	R-HSA-9664407	7.055458e-01	0.151
Leishmania phagocytosis	R-HSA-9664417	7.055458e-01	0.151
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.061790e-01	0.151
CLEC7A (Dectin-1) signaling	R-HSA-5607764	7.062991e-01	0.151
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.111900e-01	0.148
PI-3K cascade:FGFR1	R-HSA-5654689	7.153546e-01	0.145
FGFR2 alternative splicing	R-HSA-6803529	7.153546e-01	0.145
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.153546e-01	0.145
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.153546e-01	0.145
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.153546e-01	0.145
Ethanol oxidation	R-HSA-71384	7.153546e-01	0.145
Co-stimulation by CD28	R-HSA-389356	7.154555e-01	0.145
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.244848e-01	0.140
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.244848e-01	0.140
Gap junction trafficking and regulation	R-HSA-157858	7.244848e-01	0.140
Interferon Signaling	R-HSA-913531	7.252644e-01	0.140
UCH proteinases	R-HSA-5689603	7.263670e-01	0.139
Regulation of PTEN mRNA translation	R-HSA-8943723	7.278568e-01	0.138
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	7.278568e-01	0.138
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	7.278568e-01	0.138
Syndecan interactions	R-HSA-3000170	7.278568e-01	0.138
Regulation of RAS by GAPs	R-HSA-5658442	7.332707e-01	0.135
Infectious disease	R-HSA-5663205	7.341900e-01	0.134
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	7.398106e-01	0.131
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.398106e-01	0.131
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	7.398106e-01	0.131
Plasma lipoprotein assembly	R-HSA-8963898	7.398106e-01	0.131
Developmental Biology	R-HSA-1266738	7.401145e-01	0.131
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	7.418172e-01	0.130
HSF1-dependent transactivation	R-HSA-3371571	7.418172e-01	0.130
PI Metabolism	R-HSA-1483255	7.451804e-01	0.128
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	7.501283e-01	0.125
PI-3K cascade:FGFR2	R-HSA-5654695	7.512401e-01	0.124
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	7.512401e-01	0.124
Tight junction interactions	R-HSA-420029	7.512401e-01	0.124
Acyl chain remodelling of PS	R-HSA-1482801	7.512401e-01	0.124
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	7.512401e-01	0.124
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.512401e-01	0.124
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	7.546190e-01	0.122
Organelle biogenesis and maintenance	R-HSA-1852241	7.548681e-01	0.122
Response of endothelial cells to shear stress	R-HSA-9860931	7.572342e-01	0.121
Amino acids regulate mTORC1	R-HSA-9639288	7.582082e-01	0.120
Processing of DNA double-strand break ends	R-HSA-5693607	7.613038e-01	0.118
Signaling by FLT3 fusion proteins	R-HSA-9703465	7.621681e-01	0.118
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.621681e-01	0.118
TRP channels	R-HSA-3295583	7.621681e-01	0.118
MET activates PTK2 signaling	R-HSA-8874081	7.621681e-01	0.118
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	7.621681e-01	0.118
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	7.621681e-01	0.118
Platelet degranulation	R-HSA-114608	7.622776e-01	0.118
RSV-host interactions	R-HSA-9833110	7.630938e-01	0.117
Nucleotide Excision Repair	R-HSA-5696398	7.688428e-01	0.114
Packaging Of Telomere Ends	R-HSA-171306	7.726167e-01	0.112
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	7.726167e-01	0.112
RNA Polymerase I Transcription Termination	R-HSA-73863	7.726167e-01	0.112
Signaling by FGFR3 in disease	R-HSA-5655332	7.726167e-01	0.112
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.726167e-01	0.112
Maturation of hRSV A proteins	R-HSA-9828806	7.726167e-01	0.112
Signaling by NTRK2 (TRKB)	R-HSA-9006115	7.726167e-01	0.112
G alpha (z) signalling events	R-HSA-418597	7.736916e-01	0.111
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	7.804753e-01	0.108
Signaling by FGFR1	R-HSA-5654736	7.811038e-01	0.107
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.811038e-01	0.107
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.811038e-01	0.107
Activation of AMPK downstream of NMDARs	R-HSA-9619483	7.826069e-01	0.106
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	7.826069e-01	0.106
Pyroptosis	R-HSA-5620971	7.826069e-01	0.106
Stimuli-sensing channels	R-HSA-2672351	7.854350e-01	0.105
Antigen processing-Cross presentation	R-HSA-1236975	7.854350e-01	0.105
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	7.907506e-01	0.102
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	7.921587e-01	0.101
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	7.921587e-01	0.101
Downstream signaling of activated FGFR3	R-HSA-5654708	7.921587e-01	0.101
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	7.925383e-01	0.101
Amplification of signal from the kinetochores	R-HSA-141424	7.925383e-01	0.101
Early SARS-CoV-2 Infection Events	R-HSA-9772572	7.952914e-01	0.099
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	7.971267e-01	0.098
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.001068e-01	0.097
Downstream signaling of activated FGFR4	R-HSA-5654716	8.012915e-01	0.096
Peroxisomal protein import	R-HSA-9033241	8.020757e-01	0.096
Pyruvate metabolism	R-HSA-70268	8.040445e-01	0.095
Kinesins	R-HSA-983189	8.086597e-01	0.092
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.086597e-01	0.092
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	8.100234e-01	0.092
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.100234e-01	0.092
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.100234e-01	0.092
Cargo concentration in the ER	R-HSA-5694530	8.100234e-01	0.092
Trafficking of AMPA receptors	R-HSA-399719	8.100234e-01	0.092
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.100234e-01	0.092
Aspartate and asparagine metabolism	R-HSA-8963693	8.100234e-01	0.092
Developmental Cell Lineages	R-HSA-9734767	8.149949e-01	0.089
ER-Phagosome pathway	R-HSA-1236974	8.150096e-01	0.089
Aquaporin-mediated transport	R-HSA-445717	8.150478e-01	0.089
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.150478e-01	0.089
Formation of paraxial mesoderm	R-HSA-9793380	8.150478e-01	0.089
Cellular responses to mechanical stimuli	R-HSA-9855142	8.157609e-01	0.088
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	8.157923e-01	0.088
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.183721e-01	0.087
Neurotransmitter release cycle	R-HSA-112310	8.202944e-01	0.086
Base Excision Repair	R-HSA-73884	8.202944e-01	0.086
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	8.263545e-01	0.083
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.263545e-01	0.083
FGFR1 mutant receptor activation	R-HSA-1839124	8.263545e-01	0.083
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.263545e-01	0.083
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	8.263545e-01	0.083
Cilium Assembly	R-HSA-5617833	8.267014e-01	0.083
Complex I biogenesis	R-HSA-6799198	8.272546e-01	0.082
rRNA modification in the nucleus and cytosol	R-HSA-6790901	8.272546e-01	0.082
Resolution of D-Loop Structures	R-HSA-5693537	8.339864e-01	0.079
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	8.339864e-01	0.079
Glucagon signaling in metabolic regulation	R-HSA-163359	8.339864e-01	0.079
Acyl chain remodelling of PC	R-HSA-1482788	8.339864e-01	0.079
Effects of PIP2 hydrolysis	R-HSA-114508	8.339864e-01	0.079
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.339864e-01	0.079
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.339864e-01	0.079
Glutamate and glutamine metabolism	R-HSA-8964539	8.339864e-01	0.079
Signaling by Insulin receptor	R-HSA-74752	8.353829e-01	0.078
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	8.401643e-01	0.076
Assembly of the pre-replicative complex	R-HSA-68867	8.401643e-01	0.076
Dual Incision in GG-NER	R-HSA-5696400	8.412834e-01	0.075
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	8.412834e-01	0.075
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.412834e-01	0.075
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	8.412834e-01	0.075
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	8.412834e-01	0.075
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.412834e-01	0.075
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.412834e-01	0.075
Collagen formation	R-HSA-1474290	8.448252e-01	0.073
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.482601e-01	0.071
Regulation of Apoptosis	R-HSA-169911	8.482601e-01	0.071
Downstream signaling of activated FGFR2	R-HSA-5654696	8.482601e-01	0.071
Downstream signaling of activated FGFR1	R-HSA-5654687	8.482601e-01	0.071
Acyl chain remodelling of PE	R-HSA-1482839	8.482601e-01	0.071
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.482601e-01	0.071
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.493678e-01	0.071
HDR through Homologous Recombination (HRR)	R-HSA-5685942	8.495140e-01	0.071
tRNA processing	R-HSA-72306	8.499980e-01	0.071
C-type lectin receptors (CLRs)	R-HSA-5621481	8.533754e-01	0.069
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	8.537942e-01	0.069
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	8.545702e-01	0.068
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	8.546556e-01	0.068
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	8.546556e-01	0.068
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.549305e-01	0.068
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.549305e-01	0.068
FLT3 signaling in disease	R-HSA-9682385	8.549305e-01	0.068
GPVI-mediated activation cascade	R-HSA-114604	8.549305e-01	0.068
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.549305e-01	0.068
Calmodulin induced events	R-HSA-111933	8.549305e-01	0.068
CaM pathway	R-HSA-111997	8.549305e-01	0.068
Degradation of DVL	R-HSA-4641258	8.613081e-01	0.065
Degradation of AXIN	R-HSA-4641257	8.613081e-01	0.065
Cleavage of the damaged purine	R-HSA-110331	8.613081e-01	0.065
Beta-oxidation of very long chain fatty acids	R-HSA-390247	8.613081e-01	0.065
Telomere Maintenance	R-HSA-157579	8.623076e-01	0.064
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.631356e-01	0.064
COPII-mediated vesicle transport	R-HSA-204005	8.644606e-01	0.063
Fatty acyl-CoA biosynthesis	R-HSA-75105	8.644606e-01	0.063
Signaling by FGFR	R-HSA-190236	8.663987e-01	0.062
Depurination	R-HSA-73927	8.674057e-01	0.062
Purine salvage	R-HSA-74217	8.674057e-01	0.062
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	8.674057e-01	0.062
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.691324e-01	0.061
DNA Repair	R-HSA-73894	8.698527e-01	0.061
Stabilization of p53	R-HSA-69541	8.732355e-01	0.059
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.732355e-01	0.059
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	8.732355e-01	0.059
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.732355e-01	0.059
Mitotic Spindle Checkpoint	R-HSA-69618	8.742611e-01	0.058
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.779162e-01	0.057
Switching of origins to a post-replicative state	R-HSA-69052	8.780349e-01	0.056
Ca2+ pathway	R-HSA-4086398	8.780349e-01	0.056
Attenuation phase	R-HSA-3371568	8.788094e-01	0.056
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.788094e-01	0.056
Generation of second messenger molecules	R-HSA-202433	8.788094e-01	0.056
Glycogen metabolism	R-HSA-8982491	8.788094e-01	0.056
Protein localization	R-HSA-9609507	8.809657e-01	0.055
DNA Replication	R-HSA-69306	8.809657e-01	0.055
Signaling by FGFR in disease	R-HSA-1226099	8.822736e-01	0.054
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.841385e-01	0.053
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.841385e-01	0.053
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.863757e-01	0.052
Disease	R-HSA-1643685	8.887769e-01	0.051
Degradation of CRY and PER proteins	R-HSA-9932298	8.892335e-01	0.051
Intra-Golgi traffic	R-HSA-6811438	8.892335e-01	0.051
Scavenging by Class A Receptors	R-HSA-3000480	8.892335e-01	0.051
Activation of GABAB receptors	R-HSA-991365	8.941049e-01	0.049
GABA B receptor activation	R-HSA-977444	8.941049e-01	0.049
Cytosolic tRNA aminoacylation	R-HSA-379716	8.941049e-01	0.049
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.941049e-01	0.049
Incretin synthesis, secretion, and inactivation	R-HSA-400508	8.941049e-01	0.049
Ca-dependent events	R-HSA-111996	8.941049e-01	0.049
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	8.979004e-01	0.047
Integrin cell surface interactions	R-HSA-216083	8.979004e-01	0.047
Signaling by FGFR4	R-HSA-5654743	8.987622e-01	0.046
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	8.987622e-01	0.046
Signaling by SCF-KIT	R-HSA-1433557	8.987622e-01	0.046
Sensory processing of sound	R-HSA-9659379	9.014936e-01	0.045
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.032150e-01	0.044
EPHB-mediated forward signaling	R-HSA-3928662	9.032150e-01	0.044
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.032150e-01	0.044
Signaling by FGFR2	R-HSA-5654738	9.049686e-01	0.043
Translation	R-HSA-72766	9.049783e-01	0.043
Vesicle-mediated transport	R-HSA-5653656	9.051460e-01	0.043
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.074722e-01	0.042
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	9.074722e-01	0.042
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.074722e-01	0.042
Signaling by FGFR3	R-HSA-5654741	9.074722e-01	0.042
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.074722e-01	0.042
Degradation of cysteine and homocysteine	R-HSA-1614558	9.074722e-01	0.042
DAG and IP3 signaling	R-HSA-1489509	9.074722e-01	0.042
DNA Replication Pre-Initiation	R-HSA-69002	9.077234e-01	0.042
Platelet activation, signaling and aggregation	R-HSA-76002	9.102960e-01	0.041
Regulation of pyruvate metabolism	R-HSA-9861718	9.115424e-01	0.040
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.151690e-01	0.038
Intraflagellar transport	R-HSA-5620924	9.191543e-01	0.037
GPER1 signaling	R-HSA-9634597	9.191543e-01	0.037
Gluconeogenesis	R-HSA-70263	9.191543e-01	0.037
MAPK6/MAPK4 signaling	R-HSA-5687128	9.206879e-01	0.036
DNA Damage Bypass	R-HSA-73893	9.227112e-01	0.035
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.227112e-01	0.035
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.235232e-01	0.035
Signaling by FGFR2 in disease	R-HSA-5655253	9.261119e-01	0.033
Azathioprine ADME	R-HSA-9748787	9.261119e-01	0.033
Activation of NF-kappaB in B cells	R-HSA-1169091	9.293632e-01	0.032
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.324643e-01	0.030
Orc1 removal from chromatin	R-HSA-68949	9.324715e-01	0.030
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.324715e-01	0.030
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	9.354433e-01	0.029
Regulation of PTEN stability and activity	R-HSA-8948751	9.354433e-01	0.029
Smooth Muscle Contraction	R-HSA-445355	9.354433e-01	0.029
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.382845e-01	0.028
Paracetamol ADME	R-HSA-9753281	9.410008e-01	0.026
Chromosome Maintenance	R-HSA-73886	9.410824e-01	0.026
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.410824e-01	0.026
Adaptive Immune System	R-HSA-1280218	9.431325e-01	0.025
Transmission across Chemical Synapses	R-HSA-112315	9.434172e-01	0.025
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.435977e-01	0.025
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.435977e-01	0.025
Synthesis of PA	R-HSA-1483166	9.460804e-01	0.024
Dual incision in TC-NER	R-HSA-6782135	9.484540e-01	0.023
MITF-M-regulated melanocyte development	R-HSA-9730414	9.492280e-01	0.023
Amino acid transport across the plasma membrane	R-HSA-352230	9.507233e-01	0.022
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	9.526674e-01	0.021
GABA receptor activation	R-HSA-977443	9.528928e-01	0.021
tRNA Aminoacylation	R-HSA-379724	9.528928e-01	0.021
Signaling by Retinoic Acid	R-HSA-5362517	9.528928e-01	0.021
Neuronal System	R-HSA-112316	9.532534e-01	0.021
PLC beta mediated events	R-HSA-112043	9.549668e-01	0.020
Regulation of insulin secretion	R-HSA-422356	9.560790e-01	0.020
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.569497e-01	0.019
Mitochondrial protein import	R-HSA-1268020	9.569497e-01	0.019
Parasitic Infection Pathways	R-HSA-9824443	9.597723e-01	0.018
Leishmania infection	R-HSA-9658195	9.597723e-01	0.018
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.607447e-01	0.017
Degradation of the extracellular matrix	R-HSA-1474228	9.616943e-01	0.017
Separation of Sister Chromatids	R-HSA-2467813	9.627370e-01	0.016
Kidney development	R-HSA-9830369	9.656304e-01	0.015
G-protein mediated events	R-HSA-112040	9.656304e-01	0.015
SLC-mediated transport of amino acids	R-HSA-9958863	9.656304e-01	0.015
SLC transporter disorders	R-HSA-5619102	9.660418e-01	0.015
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	9.679666e-01	0.014
Synthesis of DNA	R-HSA-69239	9.698906e-01	0.013
ECM proteoglycans	R-HSA-3000178	9.712980e-01	0.013
Regulation of mitotic cell cycle	R-HSA-453276	9.712980e-01	0.013
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	9.712980e-01	0.013
Purine catabolism	R-HSA-74259	9.725626e-01	0.012
TCR signaling	R-HSA-202403	9.731435e-01	0.012
ROS and RNS production in phagocytes	R-HSA-1222556	9.749273e-01	0.011
FCERI mediated MAPK activation	R-HSA-2871796	9.751208e-01	0.011
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.760322e-01	0.011
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.760322e-01	0.011
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.794680e-01	0.009
Peptide hormone metabolism	R-HSA-2980736	9.809924e-01	0.008
Neutrophil degranulation	R-HSA-6798695	9.813749e-01	0.008
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.832889e-01	0.007
Neddylation	R-HSA-8951664	9.833705e-01	0.007
Ion channel transport	R-HSA-983712	9.836534e-01	0.007
Peroxisomal lipid metabolism	R-HSA-390918	9.840257e-01	0.007
Interferon gamma signaling	R-HSA-877300	9.859083e-01	0.006
Sulfur amino acid metabolism	R-HSA-1614635	9.860471e-01	0.006
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.860471e-01	0.006
G alpha (q) signalling events	R-HSA-416476	9.877982e-01	0.005
Downstream TCR signaling	R-HSA-202424	9.883506e-01	0.005
Cardiac conduction	R-HSA-5576891	9.898094e-01	0.004
Golgi-to-ER retrograde transport	R-HSA-8856688	9.902021e-01	0.004
G alpha (s) signalling events	R-HSA-418555	9.911315e-01	0.004
COPI-mediated anterograde transport	R-HSA-6807878	9.918806e-01	0.004
Potassium Channels	R-HSA-1296071	9.918806e-01	0.004
Integration of energy metabolism	R-HSA-163685	9.919545e-01	0.004
Post-translational protein phosphorylation	R-HSA-8957275	9.925815e-01	0.003
Synthesis of bile acids and bile salts	R-HSA-192105	9.929090e-01	0.003
Respiratory electron transport	R-HSA-611105	9.931112e-01	0.003
ABC-family proteins mediated transport	R-HSA-382556	9.932220e-01	0.003
Extra-nuclear estrogen signaling	R-HSA-9009391	9.935212e-01	0.003
Opioid Signalling	R-HSA-111885	9.943420e-01	0.002
FCERI mediated NF-kB activation	R-HSA-2871837	9.943694e-01	0.002
ER to Golgi Anterograde Transport	R-HSA-199977	9.950039e-01	0.002
Platelet homeostasis	R-HSA-418346	9.950589e-01	0.002
Phospholipid metabolism	R-HSA-1483257	9.952126e-01	0.002
Gastrulation	R-HSA-9758941	9.953874e-01	0.002
MITF-M-dependent gene expression	R-HSA-9856651	9.955681e-01	0.002
Bile acid and bile salt metabolism	R-HSA-194068	9.958757e-01	0.002
Antimicrobial peptides	R-HSA-6803157	9.960579e-01	0.002
Hemostasis	R-HSA-109582	9.960766e-01	0.002
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.967097e-01	0.001
Innate Immune System	R-HSA-168249	9.976568e-01	0.001
Disorders of transmembrane transporters	R-HSA-5619115	9.977891e-01	0.001
Formation of the cornified envelope	R-HSA-6809371	9.979990e-01	0.001
Bacterial Infection Pathways	R-HSA-9824439	9.980041e-01	0.001
Regulation of Complement cascade	R-HSA-977606	9.980874e-01	0.001
Muscle contraction	R-HSA-397014	9.981086e-01	0.001
Immune System	R-HSA-168256	9.981810e-01	0.001
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.982285e-01	0.001
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.982528e-01	0.001
Nucleotide catabolism	R-HSA-8956319	9.984746e-01	0.001
Sensory perception of taste	R-HSA-9717189	9.986682e-01	0.001
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.988933e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.989251e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.990095e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.992221e-01	0.000
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.992256e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.992391e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.992677e-01	0.000
Complement cascade	R-HSA-166658	9.993546e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.994341e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.994654e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.994854e-01	0.000
Transport to the Golgi and subsequent modification	R-HSA-948021	9.994870e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.995078e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.995300e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.995567e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.996886e-01	0.000
Drug ADME	R-HSA-9748784	9.997465e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.998267e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.998267e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.998397e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999301e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999461e-01	0.000
Keratinization	R-HSA-6805567	9.999630e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999916e-01	0.000
Fatty acid metabolism	R-HSA-8978868	9.999947e-01	0.000
GPCR ligand binding	R-HSA-500792	9.999970e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999986e-01	0.000
Metabolism of proteins	R-HSA-392499	9.999986e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999992e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999994e-01	0.000
Diseases of metabolism	R-HSA-5668914	9.999997e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
HSF1-dependent transactivation	R-HSA-3371571	1.110223e-16	15.955
Cellular response to heat stress	R-HSA-3371556	1.110223e-16	15.955
Attenuation phase	R-HSA-3371568	2.220446e-16	15.654
Cellular responses to stress	R-HSA-2262752	1.776357e-15	14.750
Cellular responses to stimuli	R-HSA-8953897	1.132427e-14	13.946
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.753664e-13	12.426
HSF1 activation	R-HSA-3371511	1.975531e-12	11.704
Cell Cycle, Mitotic	R-HSA-69278	6.165779e-11	10.210
Cell Cycle	R-HSA-1640170	1.367227e-10	9.864
Mitotic Prometaphase	R-HSA-68877	3.919394e-10	9.407
M Phase	R-HSA-68886	5.192963e-09	8.285
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.818071e-08	7.418
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	4.137777e-08	7.383
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	6.474223e-08	7.189
L1CAM interactions	R-HSA-373760	6.644716e-08	7.178
PKR-mediated signaling	R-HSA-9833482	7.092610e-08	7.149
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	8.291733e-08	7.081
Recycling pathway of L1	R-HSA-437239	1.949959e-07	6.710
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	2.475227e-07	6.606
Axon guidance	R-HSA-422475	5.732264e-07	6.242
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	6.635420e-07	6.178
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	7.982353e-07	6.098
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.026814e-06	5.989
Post NMDA receptor activation events	R-HSA-438064	1.149603e-06	5.939
Nervous system development	R-HSA-9675108	1.104291e-06	5.957
Transport of connexons to the plasma membrane	R-HSA-190872	1.183578e-06	5.927
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.608915e-06	5.793
Mitotic G2-G2/M phases	R-HSA-453274	1.859251e-06	5.731
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.557074e-06	5.592
Separation of Sister Chromatids	R-HSA-2467813	3.525906e-06	5.453
Mitotic Anaphase	R-HSA-68882	3.668269e-06	5.436
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.999737e-06	5.398
Metabolism of RNA	R-HSA-8953854	4.182061e-06	5.379
Activation of AMPK downstream of NMDARs	R-HSA-9619483	5.794334e-06	5.237
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	6.487292e-06	5.188
Gap junction trafficking and regulation	R-HSA-157858	7.523624e-06	5.124
G2/M Transition	R-HSA-69275	1.131735e-05	4.946
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.184443e-05	4.926
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.261088e-05	4.899
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.229130e-05	4.910
Gap junction trafficking	R-HSA-190828	1.312167e-05	4.882
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.773272e-05	4.751
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.756430e-05	4.755
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.844685e-05	4.734
Apoptotic execution phase	R-HSA-75153	1.934236e-05	4.713
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	2.033029e-05	4.692
Aggrephagy	R-HSA-9646399	2.280709e-05	4.642
Interferon Signaling	R-HSA-913531	4.763499e-05	4.322
Kinesins	R-HSA-983189	5.050823e-05	4.297
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	5.522713e-05	4.258
Selective autophagy	R-HSA-9663891	6.052129e-05	4.218
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	6.224672e-05	4.206
Cap-dependent Translation Initiation	R-HSA-72737	8.344913e-05	4.079
Eukaryotic Translation Initiation	R-HSA-72613	8.344913e-05	4.079
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	8.628755e-05	4.064
Apoptotic cleavage of cellular proteins	R-HSA-111465	8.418055e-05	4.075
mRNA Splicing	R-HSA-72172	1.286578e-04	3.891
mRNA Splicing - Major Pathway	R-HSA-72163	1.351112e-04	3.869
RAF activation	R-HSA-5673000	1.548109e-04	3.810
Gap junction assembly	R-HSA-190861	1.548109e-04	3.810
Chaperonin-mediated protein folding	R-HSA-390466	1.725996e-04	3.763
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.844486e-04	3.734
Influenza Infection	R-HSA-168255	2.490586e-04	3.604
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.496653e-04	3.603
Signaling by AMER1 mutants	R-HSA-4839748	2.548799e-04	3.594
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.846137e-04	3.546
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.846137e-04	3.546
Protein folding	R-HSA-391251	3.341395e-04	3.476
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.400650e-04	3.468
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.688381e-04	3.433
Diseases of mitotic cell cycle	R-HSA-9675126	4.019885e-04	3.396
AURKA Activation by TPX2	R-HSA-8854518	4.183447e-04	3.378
Golgi-to-ER retrograde transport	R-HSA-8856688	4.371181e-04	3.359
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	4.910762e-04	3.309
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	4.910762e-04	3.309
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.702037e-04	3.328
Formation of a pool of free 40S subunits	R-HSA-72689	5.032231e-04	3.298
COPI-mediated anterograde transport	R-HSA-6807878	5.554675e-04	3.255
Signaling by RAF1 mutants	R-HSA-9656223	6.166057e-04	3.210
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	6.263879e-04	3.203
Chromatin modifying enzymes	R-HSA-3247509	8.965669e-04	3.047
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	9.489725e-04	3.023
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.744878e-04	3.011
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.744878e-04	3.011
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.017722e-03	2.992
Chromatin organization	R-HSA-4839726	1.024500e-03	2.989
Oncogenic MAPK signaling	R-HSA-6802957	1.125182e-03	2.949
Centrosome maturation	R-HSA-380287	1.177281e-03	2.929
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.241358e-03	2.906
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.269660e-03	2.896
Signaling downstream of RAS mutants	R-HSA-9649948	1.269660e-03	2.896
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.269660e-03	2.896
Signaling by RAS mutants	R-HSA-6802949	1.269660e-03	2.896
Signaling by APC mutants	R-HSA-4839744	1.366667e-03	2.864
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.366667e-03	2.864
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.366667e-03	2.864
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.366667e-03	2.864
UCH proteinases	R-HSA-5689603	1.307577e-03	2.884
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.451296e-03	2.838
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.484373e-03	2.828
Nuclear Envelope Breakdown	R-HSA-2980766	1.509770e-03	2.821
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.555121e-03	2.808
Estrogen-dependent gene expression	R-HSA-9018519	1.573881e-03	2.803
ER to Golgi Anterograde Transport	R-HSA-199977	1.591636e-03	2.798
Signal Transduction	R-HSA-162582	1.794731e-03	2.746
Signaling by GSK3beta mutants	R-HSA-5339716	1.842634e-03	2.735
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	1.842634e-03	2.735
Signaling by AXIN mutants	R-HSA-4839735	1.842634e-03	2.735
Membrane Trafficking	R-HSA-199991	1.943187e-03	2.711
Mitotic Spindle Checkpoint	R-HSA-69618	2.154246e-03	2.667
Intracellular signaling by second messengers	R-HSA-9006925	2.066148e-03	2.685
Mitotic Prophase	R-HSA-68875	2.177665e-03	2.662
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	2.208688e-03	2.656
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.429817e-03	2.614
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.429817e-03	2.614
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.429817e-03	2.614
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.429817e-03	2.614
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.429817e-03	2.614
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.429817e-03	2.614
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	2.377717e-03	2.624
PLC beta mediated events	R-HSA-112043	2.383607e-03	2.623
Eukaryotic Translation Elongation	R-HSA-156842	2.594193e-03	2.586
Ca-dependent events	R-HSA-111996	2.626974e-03	2.581
Influenza Viral RNA Transcription and Replication	R-HSA-168273	2.711871e-03	2.567
Autophagy	R-HSA-9612973	2.889876e-03	2.539
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.142247e-03	2.503
Amplification of signal from the kinetochores	R-HSA-141424	3.402039e-03	2.468
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.402039e-03	2.468
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	3.389853e-03	2.470
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	3.628500e-03	2.440
Calmodulin induced events	R-HSA-111933	3.657137e-03	2.437
CaM pathway	R-HSA-111997	3.657137e-03	2.437
DAG and IP3 signaling	R-HSA-1489509	3.829922e-03	2.417
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.860274e-03	2.413
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.106714e-03	2.387
Apoptosis	R-HSA-109581	4.175866e-03	2.379
Neutrophil degranulation	R-HSA-6798695	4.340607e-03	2.362
Unfolded Protein Response (UPR)	R-HSA-381119	4.380024e-03	2.359
Peptide chain elongation	R-HSA-156902	4.399200e-03	2.357
G-protein mediated events	R-HSA-112040	4.420558e-03	2.355
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	4.464042e-03	2.350
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.913931e-03	2.309
rRNA processing in the nucleus and cytosol	R-HSA-8868773	4.591009e-03	2.338
Macroautophagy	R-HSA-1632852	4.971322e-03	2.304
Beta-catenin phosphorylation cascade	R-HSA-196299	4.999214e-03	2.301
Cell-extracellular matrix interactions	R-HSA-446353	4.999214e-03	2.301
Cilium Assembly	R-HSA-5617833	5.114392e-03	2.291
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	5.185920e-03	2.285
Cytokine Signaling in Immune system	R-HSA-1280215	5.192203e-03	2.285
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	5.207481e-03	2.283
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	5.230658e-03	2.281
Glycolysis	R-HSA-70171	5.370074e-03	2.270
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	5.423291e-03	2.266
NS1 Mediated Effects on Host Pathways	R-HSA-168276	5.423291e-03	2.266
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	5.619498e-03	2.250
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	5.831762e-03	2.234
mTORC1-mediated signalling	R-HSA-166208	5.831936e-03	2.234
Cell Cycle Checkpoints	R-HSA-69620	5.946095e-03	2.226
MET activates RAP1 and RAC1	R-HSA-8875555	6.893334e-03	2.162
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	6.136998e-03	2.212
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	6.869052e-03	2.163
Cargo trafficking to the periciliary membrane	R-HSA-5620920	6.415415e-03	2.193
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	7.201291e-03	2.143
Transport of the SLBP independent Mature mRNA	R-HSA-159227	7.663171e-03	2.116
Regulation of MECP2 expression and activity	R-HSA-9022692	7.663171e-03	2.116
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	8.240690e-03	2.084
MTOR signalling	R-HSA-165159	8.708954e-03	2.060
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	8.723565e-03	2.059
Ribosome-associated quality control	R-HSA-9948299	8.830341e-03	2.054
Eukaryotic Translation Termination	R-HSA-72764	8.864872e-03	2.052
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	9.498119e-03	2.022
Signaling by ALK in cancer	R-HSA-9700206	9.498119e-03	2.022
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.115176e-02	1.953
Translation initiation complex formation	R-HSA-72649	1.011699e-02	1.995
G1 Phase	R-HSA-69236	1.082310e-02	1.966
Cyclin D associated events in G1	R-HSA-69231	1.082310e-02	1.966
EPHB-mediated forward signaling	R-HSA-3928662	1.082310e-02	1.966
Platelet sensitization by LDL	R-HSA-432142	1.082515e-02	1.966
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.082515e-02	1.966
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.116151e-02	1.952
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.118906e-02	1.951
Programmed Cell Death	R-HSA-5357801	1.133690e-02	1.946
G alpha (12/13) signalling events	R-HSA-416482	1.153407e-02	1.938
NRAGE signals death through JNK	R-HSA-193648	1.221368e-02	1.913
Interaction between L1 and Ankyrins	R-HSA-445095	1.237191e-02	1.908
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.237191e-02	1.908
Hedgehog 'off' state	R-HSA-5610787	1.256115e-02	1.901
E2F mediated regulation of DNA replication	R-HSA-113510	1.279671e-02	1.893
Regulation of CDH1 Function	R-HSA-9764561	1.337592e-02	1.874
Selenocysteine synthesis	R-HSA-2408557	1.342536e-02	1.872
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.386301e-02	1.858
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.386301e-02	1.858
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.499764e-02	1.824
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	1.499764e-02	1.824
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.560564e-02	1.807
Viral mRNA Translation	R-HSA-192823	1.529014e-02	1.816
S Phase	R-HSA-69242	1.618024e-02	1.791
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.604528e-02	1.795
Intraflagellar transport	R-HSA-5620924	1.615495e-02	1.792
ESR-mediated signaling	R-HSA-8939211	1.401762e-02	1.853
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.591885e-02	1.798
Regulation of beta-cell development	R-HSA-186712	1.594348e-02	1.797
Opioid Signalling	R-HSA-111885	1.629357e-02	1.788
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.658417e-02	1.780
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.691080e-02	1.772
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.813798e-02	1.741
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.930958e-02	1.714
Glucose metabolism	R-HSA-70326	1.994308e-02	1.700
CHL1 interactions	R-HSA-447041	2.005135e-02	1.698
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.012820e-02	1.696
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.034662e-02	1.692
Trafficking of AMPA receptors	R-HSA-399719	2.041021e-02	1.690
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.221273e-02	1.653
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.221273e-02	1.653
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.221273e-02	1.653
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.221273e-02	1.653
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.221273e-02	1.653
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.221273e-02	1.653
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.221273e-02	1.653
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.221273e-02	1.653
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.221273e-02	1.653
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.221273e-02	1.653
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.221273e-02	1.653
Type I hemidesmosome assembly	R-HSA-446107	2.561187e-02	1.592
Formation of annular gap junctions	R-HSA-196025	2.561187e-02	1.592
G0 and Early G1	R-HSA-1538133	2.286811e-02	1.641
HCMV Early Events	R-HSA-9609690	2.417730e-02	1.617
Signaling by FGFR1 in disease	R-HSA-5655302	2.358033e-02	1.627
FGFR1 mutant receptor activation	R-HSA-1839124	2.551741e-02	1.593
Adrenoceptors	R-HSA-390696	2.561187e-02	1.592
Signaling by WNT in cancer	R-HSA-4791275	2.286811e-02	1.641
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.139622e-02	1.670
Cellular Senescence	R-HSA-2559583	2.187821e-02	1.660
Negative regulation of MAPK pathway	R-HSA-5675221	2.358033e-02	1.627
Transcriptional regulation by RUNX3	R-HSA-8878159	2.294156e-02	1.639
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.551741e-02	1.593
PIP3 activates AKT signaling	R-HSA-1257604	2.537707e-02	1.596
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.551741e-02	1.593
Transmission across Chemical Synapses	R-HSA-112315	2.465824e-02	1.608
ISG15 antiviral mechanism	R-HSA-1169408	2.234955e-02	1.651
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.561187e-02	1.592
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.591319e-02	1.586
Deubiquitination	R-HSA-5688426	2.811957e-02	1.551
Prolonged ERK activation events	R-HSA-169893	2.842622e-02	1.546
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	2.842622e-02	1.546
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.954610e-02	1.529
HDACs deacetylate histones	R-HSA-3214815	2.965897e-02	1.528
Deadenylation of mRNA	R-HSA-429947	2.977459e-02	1.526
Transport to the Golgi and subsequent modification	R-HSA-948021	3.086881e-02	1.510
Gap junction degradation	R-HSA-190873	3.191416e-02	1.496
Unwinding of DNA	R-HSA-176974	3.191416e-02	1.496
Butyrophilin (BTN) family interactions	R-HSA-8851680	3.191416e-02	1.496
Ribosomal scanning and start codon recognition	R-HSA-72702	3.207673e-02	1.494
G1/S Transition	R-HSA-69206	3.223608e-02	1.492
IRE1alpha activates chaperones	R-HSA-381070	3.229722e-02	1.491
Transcriptional Regulation by TP53	R-HSA-3700989	3.272229e-02	1.485
Signaling by FGFR1 amplification mutants	R-HSA-1839120	3.344706e-02	1.476
rRNA processing	R-HSA-72312	3.426324e-02	1.465
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	3.466419e-02	1.460
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.466419e-02	1.460
Oncogene Induced Senescence	R-HSA-2559585	3.466419e-02	1.460
Signaling by Hedgehog	R-HSA-5358351	3.483100e-02	1.458
Vesicle-mediated transport	R-HSA-5653656	3.543510e-02	1.451
mRNA Splicing - Minor Pathway	R-HSA-72165	3.680871e-02	1.434
Degradation of beta-catenin by the destruction complex	R-HSA-195253	3.681409e-02	1.434
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	3.708747e-02	1.431
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.642331e-02	1.333
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.642331e-02	1.333
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.642331e-02	1.333
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	4.180302e-02	1.379
Vpr-mediated nuclear import of PICs	R-HSA-180910	4.180302e-02	1.379
RNA Polymerase II Transcription Termination	R-HSA-73856	4.618162e-02	1.336
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.477151e-02	1.349
MET promotes cell motility	R-HSA-8875878	4.569463e-02	1.340
Chaperone Mediated Autophagy	R-HSA-9613829	4.366521e-02	1.360
Apoptosis induced DNA fragmentation	R-HSA-140342	3.894965e-02	1.409
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.642331e-02	1.333
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	3.812713e-02	1.419
Clathrin-mediated endocytosis	R-HSA-8856828	4.561594e-02	1.341
Phase 0 - rapid depolarisation	R-HSA-5576892	4.653737e-02	1.332
Activation of NOXA and translocation to mitochondria	R-HSA-111448	4.642331e-02	1.333
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.200186e-02	1.377
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.735233e-02	1.428
Regulation of PTEN gene transcription	R-HSA-8943724	4.308413e-02	1.366
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	4.191610e-02	1.378
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	4.671264e-02	1.331
Viral Infection Pathways	R-HSA-9824446	4.713733e-02	1.327
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.794348e-02	1.319
XBP1(S) activates chaperone genes	R-HSA-381038	4.814434e-02	1.317
SARS-CoV-2-host interactions	R-HSA-9705683	4.922817e-02	1.308
Transcriptional Regulation by E2F6	R-HSA-8953750	4.980423e-02	1.303
Non-integrin membrane-ECM interactions	R-HSA-3000171	5.067061e-02	1.295
Regulation of gene expression in beta cells	R-HSA-210745	5.144940e-02	1.289
MHC class II antigen presentation	R-HSA-2132295	5.320902e-02	1.274
HATs acetylate histones	R-HSA-3214847	5.322164e-02	1.274
p75 NTR receptor-mediated signalling	R-HSA-193704	5.322164e-02	1.274
Signaling by NOTCH1	R-HSA-1980143	5.380294e-02	1.269
Interleukin-12 signaling	R-HSA-9020591	5.380294e-02	1.269
Interactions of Vpr with host cellular proteins	R-HSA-176033	5.413354e-02	1.267
Signaling by ROBO receptors	R-HSA-376176	5.437760e-02	1.265
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.515553e-02	1.258
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	5.523917e-02	1.258
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	5.523917e-02	1.258
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	5.523917e-02	1.258
Co-inhibition by CTLA4	R-HSA-389513	5.592751e-02	1.252
Signal transduction by L1	R-HSA-445144	5.592751e-02	1.252
Signaling by NTRKs	R-HSA-166520	5.624952e-02	1.250
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	5.665293e-02	1.247
mRNA 3'-end processing	R-HSA-72187	5.817308e-02	1.235
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	5.868376e-02	1.231
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	6.000838e-02	1.222
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	6.091520e-02	1.215
IRS activation	R-HSA-74713	6.091520e-02	1.215
G2 Phase	R-HSA-68911	6.091520e-02	1.215
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	6.091520e-02	1.215
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	6.091520e-02	1.215
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	6.091520e-02	1.215
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	6.214777e-02	1.207
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	6.214777e-02	1.207
Gene expression (Transcription)	R-HSA-74160	6.262116e-02	1.203
Transcriptional Regulation by MECP2	R-HSA-8986944	6.318016e-02	1.199
MAP2K and MAPK activation	R-HSA-5674135	6.345556e-02	1.198
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	6.345556e-02	1.198
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.428124e-02	1.192
Signaling by MET	R-HSA-6806834	6.757748e-02	1.170
DNA strand elongation	R-HSA-69190	6.793283e-02	1.168
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	6.984657e-02	1.156
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	6.984657e-02	1.156
EPH-Ephrin signaling	R-HSA-2682334	6.995571e-02	1.155
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	7.671605e-02	1.115
Notch-HLH transcription pathway	R-HSA-350054	7.741128e-02	1.111
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.400610e-02	1.131
IPs transport between nucleus and cytosol	R-HSA-1855170	7.400610e-02	1.131
DNA Damage Recognition in GG-NER	R-HSA-5696394	8.036474e-02	1.095
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	8.036474e-02	1.095
Metabolism of non-coding RNA	R-HSA-194441	9.112410e-02	1.040
snRNP Assembly	R-HSA-191859	9.112410e-02	1.040
Signaling by FGFR1	R-HSA-5654736	7.593457e-02	1.120
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	9.363740e-02	1.029
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.593457e-02	1.120
CREB phosphorylation	R-HSA-199920	9.363740e-02	1.029
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.741128e-02	1.111
Signaling by EGFR	R-HSA-177929	7.593457e-02	1.120
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.366397e-02	1.133
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.988498e-02	1.046
Frs2-mediated activation	R-HSA-170968	7.405245e-02	1.130
Signaling by NOTCH3	R-HSA-9012852	7.122675e-02	1.147
Epigenetic regulation of gene expression	R-HSA-212165	8.858087e-02	1.053
Cellular response to starvation	R-HSA-9711097	8.234683e-02	1.084
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	7.400610e-02	1.131
Nef and signal transduction	R-HSA-164944	9.363740e-02	1.029
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	8.036474e-02	1.095
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	9.062557e-02	1.043
Cyclin E associated events during G1/S transition	R-HSA-69202	8.060499e-02	1.094
Signaling by NOTCH	R-HSA-157118	7.222036e-02	1.141
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	8.988498e-02	1.046
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	7.671605e-02	1.115
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.062557e-02	1.043
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	9.363740e-02	1.029
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	7.400610e-02	1.131
Nuclear import of Rev protein	R-HSA-180746	8.700508e-02	1.060
Developmental Biology	R-HSA-1266738	8.539803e-02	1.069
Organelle biogenesis and maintenance	R-HSA-1852241	8.216885e-02	1.085
Transcriptional regulation by RUNX1	R-HSA-8878171	7.405172e-02	1.130
Hemostasis	R-HSA-109582	7.262898e-02	1.139
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	9.370504e-02	1.028
Signalling to ERKs	R-HSA-187687	9.392269e-02	1.027
PERK regulates gene expression	R-HSA-381042	9.392269e-02	1.027
Spry regulation of FGF signaling	R-HSA-1295596	9.540484e-02	1.020
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	9.540484e-02	1.020
DCC mediated attractive signaling	R-HSA-418885	9.540484e-02	1.020
IRF3-mediated induction of type I IFN	R-HSA-3270619	9.540484e-02	1.020
HCMV Infection	R-HSA-9609646	9.624899e-02	1.017
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.671228e-02	1.015
Diseases of Telomere Maintenance	R-HSA-9673013	1.074301e-01	0.969
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.074301e-01	0.969
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.074301e-01	0.969
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.074301e-01	0.969
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.074301e-01	0.969
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	1.115075e-01	0.953
SOS-mediated signalling	R-HSA-112412	1.115075e-01	0.953
Disinhibition of SNARE formation	R-HSA-114516	1.115075e-01	0.953
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.115075e-01	0.953
Signaling by MRAS-complex mutants	R-HSA-9660537	1.301703e-01	0.885
MET receptor recycling	R-HSA-8875656	1.301703e-01	0.885
FGFR1b ligand binding and activation	R-HSA-190370	1.301703e-01	0.885
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.301703e-01	0.885
ARMS-mediated activation	R-HSA-170984	1.494838e-01	0.825
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.494838e-01	0.825
ALK mutants bind TKIs	R-HSA-9700645	1.494838e-01	0.825
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	1.069176e-01	0.971
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.069176e-01	0.971
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.189400e-01	0.925
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.314349e-01	0.881
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.314349e-01	0.881
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.314349e-01	0.881
Ephrin signaling	R-HSA-3928664	1.443647e-01	0.841
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	1.443647e-01	0.841
ATP-dependent chromatin remodelers	R-HSA-9932444	1.024116e-01	0.990
SWI/SNF chromatin remodelers	R-HSA-9932451	1.024116e-01	0.990
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.208795e-01	0.918
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.208795e-01	0.918
HIV elongation arrest and recovery	R-HSA-167287	1.306120e-01	0.884
Pausing and recovery of HIV elongation	R-HSA-167290	1.306120e-01	0.884
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.406564e-01	0.852
Formation of RNA Pol II elongation complex	R-HSA-112382	1.302585e-01	0.885
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.375624e-01	0.862
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.375624e-01	0.862
GP1b-IX-V activation signalling	R-HSA-430116	1.494838e-01	0.825
FGFR1 ligand binding and activation	R-HSA-190242	1.443647e-01	0.841
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.494838e-01	0.825
Nucleotide Excision Repair	R-HSA-5696398	1.349088e-01	0.870
Downregulation of ERBB4 signaling	R-HSA-1253288	1.301703e-01	0.885
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.494838e-01	0.825
RNA Polymerase I Transcription	R-HSA-73864	1.212416e-01	0.916
Regulation of TP53 Degradation	R-HSA-6804757	1.011124e-01	0.995
Fibronectin matrix formation	R-HSA-1566977	1.189400e-01	0.925
Long-term potentiation	R-HSA-9620244	1.024116e-01	0.990
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.375624e-01	0.862
PI3K Cascade	R-HSA-109704	1.162323e-01	0.935
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.242525e-01	0.906
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	1.189400e-01	0.925
Elevation of cytosolic Ca2+ levels	R-HSA-139853	1.314349e-01	0.881
Synthesis of DNA	R-HSA-69239	1.454087e-01	0.837
Signaling by TGFB family members	R-HSA-9006936	1.427974e-01	0.845
Formation of editosomes by ADAR proteins	R-HSA-77042	1.074301e-01	0.969
Inhibition of PKR	R-HSA-169131	1.074301e-01	0.969
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	1.069176e-01	0.971
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.443647e-01	0.841
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.324658e-01	0.878
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.443647e-01	0.841
Signaling by NOTCH4	R-HSA-9013694	9.975641e-02	1.001
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.227193e-01	0.911
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.085684e-01	0.964
PKMTs methylate histone lysines	R-HSA-3214841	1.409161e-01	0.851
RUNX3 regulates WNT signaling	R-HSA-8951430	1.115075e-01	0.953
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.115075e-01	0.953
Signaling by FGFR in disease	R-HSA-1226099	9.975641e-02	1.001
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	1.115075e-01	0.953
MAP kinase activation	R-HSA-450294	1.021291e-01	0.991
Smooth Muscle Contraction	R-HSA-445355	1.375624e-01	0.862
Regulation of TP53 Activity	R-HSA-5633007	1.427974e-01	0.845
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.369178e-01	0.864
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.114744e-01	0.953
Signaling by Hippo	R-HSA-2028269	1.314349e-01	0.881
Neuronal System	R-HSA-112316	1.364492e-01	0.865
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	1.301703e-01	0.885
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	1.306120e-01	0.884
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.459381e-01	0.836
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.298937e-01	0.886
MECP2 regulates transcription factors	R-HSA-9022707	1.115075e-01	0.953
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.494838e-01	0.825
MASTL Facilitates Mitotic Progression	R-HSA-2465910	1.494838e-01	0.825
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	1.242525e-01	0.906
Interactions of Rev with host cellular proteins	R-HSA-177243	1.324658e-01	0.878
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.071837e-01	0.970
Semaphorin interactions	R-HSA-373755	1.138222e-01	0.944
Transcriptional Regulation by VENTX	R-HSA-8853884	1.409161e-01	0.851
Uptake and function of diphtheria toxin	R-HSA-5336415	1.115075e-01	0.953
Respiratory syncytial virus genome replication	R-HSA-9834752	1.494838e-01	0.825
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.162841e-01	0.934
PTEN Regulation	R-HSA-6807070	1.135081e-01	0.945
Selenoamino acid metabolism	R-HSA-2408522	1.012335e-01	0.995
Interleukin-12 family signaling	R-HSA-447115	1.012208e-01	0.995
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.508121e-01	0.822
Activation of the pre-replicative complex	R-HSA-68962	1.509967e-01	0.821
Activation of BH3-only proteins	R-HSA-114452	1.509967e-01	0.821
MAPK family signaling cascades	R-HSA-5683057	1.516926e-01	0.819
Cell-Cell communication	R-HSA-1500931	1.538260e-01	0.813
Interactions of Tat with host cellular proteins	R-HSA-176034	1.567409e-01	0.805
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	1.567409e-01	0.805
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	1.567409e-01	0.805
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	1.567409e-01	0.805
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	1.567409e-01	0.805
Manipulation of host energy metabolism	R-HSA-9636667	1.567409e-01	0.805
Breakdown of the nuclear lamina	R-HSA-352238	1.567409e-01	0.805
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.576210e-01	0.802
Regulation of signaling by CBL	R-HSA-912631	1.576918e-01	0.802
STING mediated induction of host immune responses	R-HSA-1834941	1.576918e-01	0.802
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.598718e-01	0.796
Interleukin-17 signaling	R-HSA-448424	1.598718e-01	0.796
Ion homeostasis	R-HSA-5578775	1.605752e-01	0.794
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.605752e-01	0.794
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.605752e-01	0.794
TBC/RABGAPs	R-HSA-8854214	1.676001e-01	0.776
Host Interactions of HIV factors	R-HSA-162909	1.678029e-01	0.775
IRS-mediated signalling	R-HSA-112399	1.685943e-01	0.773
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.685943e-01	0.773
Folding of actin by CCT/TriC	R-HSA-390450	1.693194e-01	0.771
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	1.693194e-01	0.771
PI3K/AKT activation	R-HSA-198203	1.693194e-01	0.771
Signal attenuation	R-HSA-74749	1.693194e-01	0.771
Josephin domain DUBs	R-HSA-5689877	1.693194e-01	0.771
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	1.693194e-01	0.771
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.693194e-01	0.771
Signaling by Leptin	R-HSA-2586552	1.693194e-01	0.771
RAF/MAP kinase cascade	R-HSA-5673001	1.696724e-01	0.770
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.713785e-01	0.766
Negative regulation of MET activity	R-HSA-6807004	1.713785e-01	0.766
Protein hydroxylation	R-HSA-9629569	1.713785e-01	0.766
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.724976e-01	0.763
Signaling by FGFR	R-HSA-190236	1.727059e-01	0.763
Inositol phosphate metabolism	R-HSA-1483249	1.734107e-01	0.761
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.743818e-01	0.758
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	2.033303e-01	0.692
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	2.033303e-01	0.692
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	2.473483e-01	0.607
MET activates PTPN11	R-HSA-8865999	2.473483e-01	0.607
Signaling by MAP2K mutants	R-HSA-9652169	2.889367e-01	0.539
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.889367e-01	0.539
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	3.282295e-01	0.484
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.282295e-01	0.484
Defective F9 activation	R-HSA-9673221	3.282295e-01	0.484
FLT3 signaling by CBL mutants	R-HSA-9706377	3.282295e-01	0.484
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	3.282295e-01	0.484
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	3.282295e-01	0.484
Signaling by activated point mutants of FGFR1	R-HSA-1839122	2.101024e-01	0.678
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.308498e-01	0.637
Scavenging by Class F Receptors	R-HSA-3000484	2.308498e-01	0.637
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	2.517177e-01	0.599
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.517177e-01	0.599
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.853877e-01	0.732
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.853877e-01	0.732
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.996829e-01	0.700
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.726293e-01	0.564
PI-3K cascade:FGFR1	R-HSA-5654689	2.142285e-01	0.669
Erythropoietin activates RAS	R-HSA-9027284	2.935164e-01	0.532
Processive synthesis on the lagging strand	R-HSA-69183	2.935164e-01	0.532
Striated Muscle Contraction	R-HSA-390522	1.949774e-01	0.710
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	3.143178e-01	0.503
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.143178e-01	0.503
Phosphorylation of the APC/C	R-HSA-176412	3.143178e-01	0.503
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	3.554532e-01	0.449
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	2.159389e-01	0.666
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.668830e-01	0.574
Signaling by Erythropoietin	R-HSA-9006335	3.202778e-01	0.494
HIV Transcription Elongation	R-HSA-167169	2.793355e-01	0.554
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.793355e-01	0.554
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.793355e-01	0.554
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.679840e-01	0.572
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	3.171605e-01	0.499
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	3.004327e-01	0.522
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.047071e-01	0.516
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.445334e-01	0.463
EGFR downregulation	R-HSA-182971	3.510492e-01	0.455
Signaling by EGFR in Cancer	R-HSA-1643713	2.742342e-01	0.562
Negative regulation of FGFR3 signaling	R-HSA-5654732	3.048889e-01	0.516
Negative regulation of FGFR4 signaling	R-HSA-5654733	3.202778e-01	0.494
Integrin signaling	R-HSA-354192	1.836239e-01	0.736
IRS-related events triggered by IGF1R	R-HSA-2428928	2.022460e-01	0.694
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.048889e-01	0.516
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.049906e-01	0.688
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	2.423106e-01	0.616
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.864061e-01	0.730
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.243589e-01	0.489
Regulation of endogenous retroelements	R-HSA-9842860	3.154080e-01	0.501
Regulation of gap junction activity	R-HSA-191650	2.889367e-01	0.539
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	3.282295e-01	0.484
RUNX3 regulates p14-ARF	R-HSA-8951936	2.308498e-01	0.637
Formation of axial mesoderm	R-HSA-9796292	2.517177e-01	0.599
RNA Polymerase I Transcription Termination	R-HSA-73863	2.895319e-01	0.538
ER-Phagosome pathway	R-HSA-1236974	3.245539e-01	0.489
Negative regulation of the PI3K/AKT network	R-HSA-199418	3.130163e-01	0.504
Formation of the posterior neural plate	R-HSA-9832991	1.895606e-01	0.722
Activation of AKT2	R-HSA-165158	3.282295e-01	0.484
PTK6 Down-Regulation	R-HSA-8849472	3.282295e-01	0.484
FGFR1c ligand binding and activation	R-HSA-190373	2.517177e-01	0.599
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.554532e-01	0.449
Degradation of GLI1 by the proteasome	R-HSA-5610780	3.044902e-01	0.516
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.573428e-01	0.589
DNA Replication Pre-Initiation	R-HSA-69002	2.542736e-01	0.595
Mitophagy	R-HSA-5205647	2.065406e-01	0.685
Inhibition of nitric oxide production	R-HSA-9636249	2.473483e-01	0.607
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.282295e-01	0.484
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.935164e-01	0.532
WNT5A-dependent internalization of FZD4	R-HSA-5099900	3.143178e-01	0.503
IGF1R signaling cascade	R-HSA-2428924	2.289494e-01	0.640
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.936100e-01	0.713
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.936100e-01	0.713
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.936100e-01	0.713
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.936100e-01	0.713
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	2.321594e-01	0.634
Sensing of DNA Double Strand Breaks	R-HSA-5693548	2.101024e-01	0.678
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.110193e-01	0.676
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.223977e-01	0.492
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.380917e-01	0.623
Assembly of the pre-replicative complex	R-HSA-68867	2.354983e-01	0.628
Insulin receptor signalling cascade	R-HSA-74751	2.289494e-01	0.640
mRNA Editing: A to I Conversion	R-HSA-75064	2.033303e-01	0.692
C6 deamination of adenosine	R-HSA-75102	2.033303e-01	0.692
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	2.033303e-01	0.692
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	2.033303e-01	0.692
STAT6-mediated induction of chemokines	R-HSA-3249367	2.473483e-01	0.607
MET interacts with TNS proteins	R-HSA-8875513	2.473483e-01	0.607
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.889367e-01	0.539
ERKs are inactivated	R-HSA-202670	2.101024e-01	0.678
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.308498e-01	0.637
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	2.517177e-01	0.599
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	3.143178e-01	0.503
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.349794e-01	0.475
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.864061e-01	0.730
Viral Messenger RNA Synthesis	R-HSA-168325	2.022460e-01	0.694
Switching of origins to a post-replicative state	R-HSA-69052	1.818423e-01	0.740
Orc1 removal from chromatin	R-HSA-68949	2.573428e-01	0.589
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	2.918766e-01	0.535
Signaling by ERBB2 in Cancer	R-HSA-1227990	3.356728e-01	0.474
Oxidative Stress Induced Senescence	R-HSA-2559580	1.984606e-01	0.702
Signaling by FGFR4	R-HSA-5654743	3.298721e-01	0.482
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	2.742342e-01	0.562
Signaling by Insulin receptor	R-HSA-74752	2.279110e-01	0.642
Laminin interactions	R-HSA-3000157	2.590243e-01	0.587
Signaling by FGFR3	R-HSA-5654741	3.553600e-01	0.449
Translation	R-HSA-72766	2.116338e-01	0.674
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	3.048889e-01	0.516
HIV Life Cycle	R-HSA-162587	2.961947e-01	0.528
Response of endothelial cells to shear stress	R-HSA-9860931	2.119115e-01	0.674
Acetylcholine regulates insulin secretion	R-HSA-399997	3.349794e-01	0.475
MAPK1/MAPK3 signaling	R-HSA-5684996	1.957984e-01	0.708
Cellular responses to mechanical stimuli	R-HSA-9855142	2.914919e-01	0.535
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.202778e-01	0.494
Signaling by NOTCH2	R-HSA-1980145	2.065406e-01	0.685
Signaling by VEGF	R-HSA-194138	1.787985e-01	0.748
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.895606e-01	0.722
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.935164e-01	0.532
Deadenylation-dependent mRNA decay	R-HSA-429914	3.334492e-01	0.477
HIV Infection	R-HSA-162906	3.333585e-01	0.477
Signaling by WNT	R-HSA-195721	2.036136e-01	0.691
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.456601e-01	0.461
Platelet calcium homeostasis	R-HSA-418360	3.202778e-01	0.494
rRNA modification in the nucleus and cytosol	R-HSA-6790901	2.199228e-01	0.658
G2/M Checkpoints	R-HSA-69481	1.901244e-01	0.721
Protein ubiquitination	R-HSA-8852135	3.342512e-01	0.476
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.456601e-01	0.461
Platelet activation, signaling and aggregation	R-HSA-76002	2.384913e-01	0.623
Extra-nuclear estrogen signaling	R-HSA-9009391	1.918744e-01	0.717
Intracellular oxygen transport	R-HSA-8981607	2.473483e-01	0.607
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	2.889367e-01	0.539
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	3.282295e-01	0.484
Inositol transporters	R-HSA-429593	3.282295e-01	0.484
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.935164e-01	0.532
Activation of ATR in response to replication stress	R-HSA-176187	1.836239e-01	0.736
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.349794e-01	0.475
RNA Polymerase II Transcription	R-HSA-73857	3.279935e-01	0.484
Netrin-1 signaling	R-HSA-373752	3.426101e-01	0.465
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.936100e-01	0.713
Regulation of PTEN stability and activity	R-HSA-8948751	2.679840e-01	0.572
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.553600e-01	0.449
Muscle contraction	R-HSA-397014	2.515696e-01	0.599
GABA synthesis, release, reuptake and degradation	R-HSA-888590	3.356728e-01	0.474
Gastrulation	R-HSA-9758941	3.530106e-01	0.452
Platelet homeostasis	R-HSA-418346	3.572559e-01	0.447
tRNA processing in the nucleus	R-HSA-6784531	2.110193e-01	0.676
TCF dependent signaling in response to WNT	R-HSA-201681	2.637965e-01	0.579
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	3.047071e-01	0.516
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.320477e-01	0.479
Signaling by Nuclear Receptors	R-HSA-9006931	2.688798e-01	0.570
SMAC (DIABLO) binds to IAPs	R-HSA-111463	3.282295e-01	0.484
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	3.282295e-01	0.484
NrCAM interactions	R-HSA-447038	3.282295e-01	0.484
Cytochrome c-mediated apoptotic response	R-HSA-111461	2.101024e-01	0.678
Platelet Adhesion to exposed collagen	R-HSA-75892	2.517177e-01	0.599
DARPP-32 events	R-HSA-180024	3.202778e-01	0.494
Gluconeogenesis	R-HSA-70263	2.159389e-01	0.666
Nuclear signaling by ERBB4	R-HSA-1251985	2.793355e-01	0.554
Sensory processing of sound	R-HSA-9659379	2.291864e-01	0.640
Signaling by ERBB4	R-HSA-1236394	3.243589e-01	0.489
Protein methylation	R-HSA-8876725	2.935164e-01	0.532
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.554532e-01	0.449
Cell junction organization	R-HSA-446728	1.879400e-01	0.726
Downregulation of ERBB2 signaling	R-HSA-8863795	3.356728e-01	0.474
Immune System	R-HSA-168256	3.348270e-01	0.475
Cellular response to chemical stress	R-HSA-9711123	2.123099e-01	0.673
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.092783e-01	0.679
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.092783e-01	0.679
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	2.033303e-01	0.692
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.517177e-01	0.599
Formation of the anterior neural plate	R-HSA-9823739	2.935164e-01	0.532
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.554532e-01	0.449
FOXO-mediated transcription	R-HSA-9614085	2.907838e-01	0.536
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.826826e-01	0.549
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.826826e-01	0.549
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.826826e-01	0.549
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	3.409613e-01	0.467
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.836239e-01	0.736
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	3.143178e-01	0.503
SARS-CoV-1-host interactions	R-HSA-9692914	3.572559e-01	0.447
ChREBP activates metabolic gene expression	R-HSA-163765	1.895606e-01	0.722
MITF-M-dependent gene expression	R-HSA-9856651	2.521176e-01	0.598
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.101024e-01	0.678
Growth hormone receptor signaling	R-HSA-982772	2.289895e-01	0.640
TRP channels	R-HSA-3295583	2.742342e-01	0.562
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.918766e-01	0.535
Transcriptional Regulation by NPAS4	R-HSA-9634815	2.573428e-01	0.589
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.258133e-01	0.646
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.143178e-01	0.503
NPAS4 regulates expression of target genes	R-HSA-9768919	2.065406e-01	0.685
Potential therapeutics for SARS	R-HSA-9679191	2.521176e-01	0.598
SARS-CoV-2 Infection	R-HSA-9694516	2.133568e-01	0.671
Formation of paraxial mesoderm	R-HSA-9793380	3.556406e-01	0.449
SARS-CoV Infections	R-HSA-9679506	3.036371e-01	0.518
Death Receptor Signaling	R-HSA-73887	2.770246e-01	0.557
Signaling by Interleukins	R-HSA-449147	2.564420e-01	0.591
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	2.668830e-01	0.574
Class I MHC mediated antigen processing & presentation	R-HSA-983169	3.608629e-01	0.443
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.614314e-01	0.442
Noncanonical activation of NOTCH3	R-HSA-9017802	3.653532e-01	0.437
PTK6 Regulates Cell Cycle	R-HSA-8849470	3.653532e-01	0.437
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.653532e-01	0.437
Signaling by MAPK mutants	R-HSA-9652817	3.653532e-01	0.437
CLEC7A/inflammasome pathway	R-HSA-5660668	3.653532e-01	0.437
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.653532e-01	0.437
Synthesis of PS	R-HSA-1483101	3.653532e-01	0.437
PKB-mediated events	R-HSA-109703	3.653532e-01	0.437
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	3.653532e-01	0.437
PDE3B signalling	R-HSA-165160	3.653532e-01	0.437
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	3.653532e-01	0.437
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	3.653532e-01	0.437
Signalling to p38 via RIT and RIN	R-HSA-187706	3.653532e-01	0.437
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	3.653532e-01	0.437
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.653532e-01	0.437
Gene Silencing by RNA	R-HSA-211000	3.657079e-01	0.437
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	3.681080e-01	0.434
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	3.693486e-01	0.433
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	3.693486e-01	0.433
Antigen processing-Cross presentation	R-HSA-1236975	3.741775e-01	0.427
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.741775e-01	0.427
GAB1 signalosome	R-HSA-180292	3.756969e-01	0.425
Apoptotic factor-mediated response	R-HSA-111471	3.756969e-01	0.425
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.756969e-01	0.425
Nephron development	R-HSA-9831926	3.756969e-01	0.425
Mismatch Repair	R-HSA-5358508	3.756969e-01	0.425
Maternal to zygotic transition (MZT)	R-HSA-9816359	3.772823e-01	0.423
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	3.808406e-01	0.419
DNA Double-Strand Break Repair	R-HSA-5693532	3.813510e-01	0.419
DNA Replication	R-HSA-69306	3.813510e-01	0.419
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.816559e-01	0.418
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.826606e-01	0.417
Signaling by FGFR2	R-HSA-5654738	3.840935e-01	0.416
Co-stimulation by CD28	R-HSA-389356	3.935450e-01	0.405
NGF-stimulated transcription	R-HSA-9031628	3.935450e-01	0.405
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.956734e-01	0.403
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.956734e-01	0.403
Translesion Synthesis by POLH	R-HSA-110320	3.956734e-01	0.403
Other interleukin signaling	R-HSA-449836	3.956734e-01	0.403
Specification of the neural plate border	R-HSA-9834899	3.956734e-01	0.403
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	4.004275e-01	0.397
Erythropoietin activates STAT5	R-HSA-9027283	4.004275e-01	0.397
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	4.004275e-01	0.397
G2/M DNA replication checkpoint	R-HSA-69478	4.004275e-01	0.397
Neurofascin interactions	R-HSA-447043	4.004275e-01	0.397
VLDL assembly	R-HSA-8866423	4.004275e-01	0.397
DNA Damage Bypass	R-HSA-73893	4.062089e-01	0.391
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	4.096553e-01	0.388
Ub-specific processing proteases	R-HSA-5689880	4.098967e-01	0.387
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	4.119298e-01	0.385
Negative regulation of FGFR2 signaling	R-HSA-5654727	4.119298e-01	0.385
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	4.119298e-01	0.385
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	4.153505e-01	0.382
Nephrin family interactions	R-HSA-373753	4.153505e-01	0.382
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	4.166459e-01	0.380
Platelet degranulation	R-HSA-114608	4.170806e-01	0.380
DNA Double Strand Break Response	R-HSA-5693606	4.222538e-01	0.374
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	4.240215e-01	0.373
Interferon gamma signaling	R-HSA-877300	4.241851e-01	0.372
Late Phase of HIV Life Cycle	R-HSA-162599	4.247013e-01	0.372
Downstream signaling of activated FGFR1	R-HSA-5654687	4.268954e-01	0.370
Activation of NF-kappaB in B cells	R-HSA-1169091	4.313685e-01	0.365
Hedgehog ligand biogenesis	R-HSA-5358346	4.313685e-01	0.365
MET activates PI3K/AKT signaling	R-HSA-8851907	4.335654e-01	0.363
IFNG signaling activates MAPKs	R-HSA-9732724	4.335654e-01	0.363
Cohesin Loading onto Chromatin	R-HSA-2470946	4.335654e-01	0.363
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	4.335654e-01	0.363
Reuptake of GABA	R-HSA-888593	4.335654e-01	0.363
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.335654e-01	0.363
LDL remodeling	R-HSA-8964041	4.335654e-01	0.363
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	4.335654e-01	0.363
Regulation of PTEN localization	R-HSA-8948747	4.335654e-01	0.363
Maturation of replicase proteins	R-HSA-9694301	4.335654e-01	0.363
Protein-protein interactions at synapses	R-HSA-6794362	4.339582e-01	0.363
MAPK6/MAPK4 signaling	R-HSA-5687128	4.339582e-01	0.363
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.347003e-01	0.362
Lagging Strand Synthesis	R-HSA-69186	4.347003e-01	0.362
PKA-mediated phosphorylation of CREB	R-HSA-111931	4.347003e-01	0.362
Basigin interactions	R-HSA-210991	4.347003e-01	0.362
ERK/MAPK targets	R-HSA-198753	4.347003e-01	0.362
Early Phase of HIV Life Cycle	R-HSA-162594	4.347003e-01	0.362
Lysosome Vesicle Biogenesis	R-HSA-432720	4.417246e-01	0.355
RUNX2 regulates bone development	R-HSA-8941326	4.417246e-01	0.355
FLT3 signaling in disease	R-HSA-9682385	4.417246e-01	0.355
RET signaling	R-HSA-8853659	4.417246e-01	0.355
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	4.420809e-01	0.354
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	4.438423e-01	0.353
Neurexins and neuroligins	R-HSA-6794361	4.438423e-01	0.353
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.438423e-01	0.353
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.442423e-01	0.352
Adaptive Immune System	R-HSA-1280218	4.464092e-01	0.350
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.515375e-01	0.345
MITF-M-regulated melanocyte development	R-HSA-9730414	4.534525e-01	0.343
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	4.536989e-01	0.343
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.536989e-01	0.343
Mitochondrial calcium ion transport	R-HSA-8949215	4.536989e-01	0.343
COPII-mediated vesicle transport	R-HSA-204005	4.551609e-01	0.342
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	4.562318e-01	0.341
phospho-PLA2 pathway	R-HSA-111995	4.648737e-01	0.333
Activated NTRK2 signals through PI3K	R-HSA-9028335	4.648737e-01	0.333
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.648737e-01	0.333
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	4.648737e-01	0.333
Fructose biosynthesis	R-HSA-5652227	4.648737e-01	0.333
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.648737e-01	0.333
ROBO receptors bind AKAP5	R-HSA-9010642	4.648737e-01	0.333
Interleukin-23 signaling	R-HSA-9020933	4.648737e-01	0.333
Regulation of mitotic cell cycle	R-HSA-453276	4.660195e-01	0.332
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	4.660195e-01	0.332
NoRC negatively regulates rRNA expression	R-HSA-427413	4.660195e-01	0.332
Rab regulation of trafficking	R-HSA-9007101	4.673574e-01	0.330
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	4.685274e-01	0.329
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	4.685274e-01	0.329
FGFR2 alternative splicing	R-HSA-6803529	4.723261e-01	0.326
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	4.723261e-01	0.326
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	4.723261e-01	0.326
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.723261e-01	0.326
RAF-independent MAPK1/3 activation	R-HSA-112409	4.723261e-01	0.326
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	4.723261e-01	0.326
Transcriptional regulation by small RNAs	R-HSA-5578749	4.768115e-01	0.322
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	4.807202e-01	0.318
Adherens junctions interactions	R-HSA-418990	4.847424e-01	0.314
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	4.852487e-01	0.314
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	4.852487e-01	0.314
Stabilization of p53	R-HSA-69541	4.852487e-01	0.314
Generic Transcription Pathway	R-HSA-212436	4.887319e-01	0.311
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	4.905649e-01	0.309
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	4.905649e-01	0.309
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	4.905649e-01	0.309
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.905649e-01	0.309
Syndecan interactions	R-HSA-3000170	4.905649e-01	0.309
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	4.928016e-01	0.307
Detoxification of Reactive Oxygen Species	R-HSA-3299685	4.928016e-01	0.307
DNA Repair	R-HSA-73894	4.941361e-01	0.306
Lipophagy	R-HSA-9613354	4.944532e-01	0.306
mRNA Editing	R-HSA-75072	4.944532e-01	0.306
WNT mediated activation of DVL	R-HSA-201688	4.944532e-01	0.306
Regulation of NPAS4 gene transcription	R-HSA-9768777	4.944532e-01	0.306
Regulation of CDH11 gene transcription	R-HSA-9762293	4.944532e-01	0.306
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	4.970290e-01	0.304
G2/M DNA damage checkpoint	R-HSA-69473	4.981703e-01	0.303
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	4.993933e-01	0.302
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	4.993933e-01	0.302
Regulation of RUNX3 expression and activity	R-HSA-8941858	4.993933e-01	0.302
Chromosome Maintenance	R-HSA-73886	5.006514e-01	0.300
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.023780e-01	0.299
Protein localization	R-HSA-9609507	5.066304e-01	0.295
SHC-mediated cascade:FGFR1	R-HSA-5654688	5.084013e-01	0.294
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	5.084013e-01	0.294
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	5.084013e-01	0.294
Mitochondrial RNA degradation	R-HSA-9836573	5.084013e-01	0.294
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	5.087251e-01	0.294
Hh mutants are degraded by ERAD	R-HSA-5362768	5.133378e-01	0.290
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.133378e-01	0.290
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	5.139411e-01	0.289
Dual incision in TC-NER	R-HSA-6782135	5.165992e-01	0.287
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	5.170659e-01	0.286
Ion channel transport	R-HSA-983712	5.181618e-01	0.286
MAPK3 (ERK1) activation	R-HSA-110056	5.223994e-01	0.282
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.223994e-01	0.282
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	5.223994e-01	0.282
DNA replication initiation	R-HSA-68952	5.223994e-01	0.282
Metal sequestration by antimicrobial proteins	R-HSA-6799990	5.223994e-01	0.282
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	5.223994e-01	0.282
Pexophagy	R-HSA-9664873	5.223994e-01	0.282
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	5.223994e-01	0.282
Defective factor IX causes hemophilia B	R-HSA-9668250	5.223994e-01	0.282
Formation of apoptosome	R-HSA-111458	5.223994e-01	0.282
Regulation of the apoptosome activity	R-HSA-9627069	5.223994e-01	0.282
Receptor Mediated Mitophagy	R-HSA-8934903	5.223994e-01	0.282
Stimuli-sensing channels	R-HSA-2672351	5.233934e-01	0.281
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.258241e-01	0.279
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.258241e-01	0.279
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.258241e-01	0.279
Acyl chain remodelling of PS	R-HSA-1482801	5.258241e-01	0.279
HDMs demethylate histones	R-HSA-3214842	5.258241e-01	0.279
Sema4D in semaphorin signaling	R-HSA-400685	5.258241e-01	0.279
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	5.258241e-01	0.279
Interleukin-7 signaling	R-HSA-1266695	5.258241e-01	0.279
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	5.270729e-01	0.278
Extension of Telomeres	R-HSA-180786	5.283011e-01	0.277
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	5.283011e-01	0.277
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	5.283011e-01	0.277
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	5.368152e-01	0.270
PCP/CE pathway	R-HSA-4086400	5.398262e-01	0.268
Signaling by ERBB2	R-HSA-1227986	5.398631e-01	0.268
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	5.405902e-01	0.267
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	5.406792e-01	0.267
MyD88-independent TLR4 cascade	R-HSA-166166	5.406792e-01	0.267
Developmental Cell Lineages	R-HSA-9734767	5.421728e-01	0.266
MET activates PTK2 signaling	R-HSA-8874081	5.428245e-01	0.265
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	5.428245e-01	0.265
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.428245e-01	0.265
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	5.428245e-01	0.265
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	5.428245e-01	0.265
SARS-CoV-1 Infection	R-HSA-9678108	5.436426e-01	0.265
PECAM1 interactions	R-HSA-210990	5.488024e-01	0.261
Conjugation of benzoate with glycine	R-HSA-177135	5.488024e-01	0.261
vRNP Assembly	R-HSA-192905	5.488024e-01	0.261
Chylomicron assembly	R-HSA-8963888	5.488024e-01	0.261
Synthesis of PI	R-HSA-1483226	5.488024e-01	0.261
Suppression of apoptosis	R-HSA-9635465	5.488024e-01	0.261
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	5.488024e-01	0.261
Prostanoid ligand receptors	R-HSA-391908	5.488024e-01	0.261
Hh mutants abrogate ligand secretion	R-HSA-5387390	5.538822e-01	0.257
Response of Mtb to phagocytosis	R-HSA-9637690	5.538822e-01	0.257
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.593960e-01	0.252
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	5.593960e-01	0.252
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	5.600422e-01	0.252
NCAM signaling for neurite out-growth	R-HSA-375165	5.625441e-01	0.250
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	5.625441e-01	0.250
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.625441e-01	0.250
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	5.669423e-01	0.246
RMTs methylate histone arginines	R-HSA-3214858	5.669423e-01	0.246
Amine ligand-binding receptors	R-HSA-375280	5.669423e-01	0.246
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.669423e-01	0.246
Processing of DNA double-strand break ends	R-HSA-5693607	5.699818e-01	0.244
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.736528e-01	0.241
Signaling by PTK6	R-HSA-8848021	5.736528e-01	0.241
Anchoring fibril formation	R-HSA-2214320	5.737473e-01	0.241
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	5.737473e-01	0.241
Endosomal/Vacuolar pathway	R-HSA-1236977	5.737473e-01	0.241
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	5.737473e-01	0.241
NF-kB is activated and signals survival	R-HSA-209560	5.737473e-01	0.241
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.737473e-01	0.241
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.737473e-01	0.241
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	5.737473e-01	0.241
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.737473e-01	0.241
Activation of RAC1	R-HSA-428540	5.737473e-01	0.241
Integration of provirus	R-HSA-162592	5.737473e-01	0.241
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.744420e-01	0.241
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.755341e-01	0.240
Formation of the Early Elongation Complex	R-HSA-113418	5.755341e-01	0.240
Insulin receptor recycling	R-HSA-77387	5.755341e-01	0.240
Cell-cell junction organization	R-HSA-421270	5.757631e-01	0.240
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	5.797649e-01	0.237
Nucleosome assembly	R-HSA-774815	5.797649e-01	0.237
Defective CFTR causes cystic fibrosis	R-HSA-5678895	5.797649e-01	0.237
Ion transport by P-type ATPases	R-HSA-936837	5.846008e-01	0.233
Post-translational protein phosphorylation	R-HSA-8957275	5.855186e-01	0.232
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.912360e-01	0.228
mRNA Capping	R-HSA-72086	5.912360e-01	0.228
Termination of translesion DNA synthesis	R-HSA-5656169	5.912360e-01	0.228
Signaling by TGFBR3	R-HSA-9839373	5.923452e-01	0.227
Cellular response to hypoxia	R-HSA-1234174	5.953842e-01	0.225
Repression of WNT target genes	R-HSA-4641265	5.973145e-01	0.224
VLDLR internalisation and degradation	R-HSA-8866427	5.973145e-01	0.224
Conjugation of salicylate with glycine	R-HSA-177128	5.973145e-01	0.224
p75NTR recruits signalling complexes	R-HSA-209543	5.973145e-01	0.224
Signaling by LTK	R-HSA-9842663	5.973145e-01	0.224
Trafficking and processing of endosomal TLR	R-HSA-1679131	5.973145e-01	0.224
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.973145e-01	0.224
Polymerase switching	R-HSA-69091	5.973145e-01	0.224
Leading Strand Synthesis	R-HSA-69109	5.973145e-01	0.224
Regulation of IFNG signaling	R-HSA-877312	5.973145e-01	0.224
Role of second messengers in netrin-1 signaling	R-HSA-418890	5.973145e-01	0.224
Disorders of Nervous System Development	R-HSA-9697154	5.973145e-01	0.224
Pervasive developmental disorders	R-HSA-9005895	5.973145e-01	0.224
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.973145e-01	0.224
OAS antiviral response	R-HSA-8983711	5.973145e-01	0.224
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.973145e-01	0.224
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.007318e-01	0.221
RNA Polymerase III Transcription Initiation	R-HSA-76046	6.065007e-01	0.217
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.164427e-01	0.210
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	6.178533e-01	0.209
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	6.195800e-01	0.208
Maturation of nucleoprotein	R-HSA-9683610	6.195800e-01	0.208
Interleukin-6 signaling	R-HSA-1059683	6.195800e-01	0.208
Replication of the SARS-CoV-1 genome	R-HSA-9682706	6.195800e-01	0.208
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	6.213284e-01	0.207
Cargo concentration in the ER	R-HSA-5694530	6.213284e-01	0.207
Downstream signal transduction	R-HSA-186763	6.213284e-01	0.207
Homology Directed Repair	R-HSA-5693538	6.227536e-01	0.206
Transcription of the HIV genome	R-HSA-167172	6.267118e-01	0.203
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.270415e-01	0.203
Degradation of CDH1	R-HSA-9766229	6.285943e-01	0.202
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.285943e-01	0.202
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.285943e-01	0.202
Transcriptional regulation by RUNX2	R-HSA-8878166	6.305056e-01	0.200
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	6.357208e-01	0.197
Beta-catenin independent WNT signaling	R-HSA-3858494	6.400459e-01	0.194
Integration of energy metabolism	R-HSA-163685	6.400459e-01	0.194
Azathioprine ADME	R-HSA-9748787	6.401713e-01	0.194
Removal of the Flap Intermediate	R-HSA-69166	6.406157e-01	0.193
Retrograde neurotrophin signalling	R-HSA-177504	6.406157e-01	0.193
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.406157e-01	0.193
Synthesis of IPs in the nucleus	R-HSA-1855191	6.406157e-01	0.193
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	6.406157e-01	0.193
Hydrolysis of LPC	R-HSA-1483115	6.406157e-01	0.193
NRIF signals cell death from the nucleus	R-HSA-205043	6.406157e-01	0.193
Signaling by FGFR4 in disease	R-HSA-5655291	6.406157e-01	0.193
Respiratory syncytial virus genome transcription	R-HSA-9828642	6.406157e-01	0.193
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	6.406157e-01	0.193
Regulation of KIT signaling	R-HSA-1433559	6.406157e-01	0.193
Signal regulatory protein family interactions	R-HSA-391160	6.406157e-01	0.193
Acyl chain remodeling of CL	R-HSA-1482798	6.406157e-01	0.193
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	6.406157e-01	0.193
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	6.467176e-01	0.189
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	6.467176e-01	0.189
Regulation of CDH1 Gene Transcription	R-HSA-9764560	6.467176e-01	0.189
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.496807e-01	0.187
G-protein beta:gamma signalling	R-HSA-397795	6.496807e-01	0.187
Regulation of necroptotic cell death	R-HSA-5675482	6.496807e-01	0.187
Hedgehog 'on' state	R-HSA-5632684	6.564504e-01	0.183
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.604893e-01	0.180
RNA Polymerase III Chain Elongation	R-HSA-73780	6.604893e-01	0.180
Protein lipoylation	R-HSA-9857492	6.604893e-01	0.180
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	6.604893e-01	0.180
p75NTR signals via NF-kB	R-HSA-193639	6.604893e-01	0.180
Signaling by Activin	R-HSA-1502540	6.604893e-01	0.180
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	6.604893e-01	0.180
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.604893e-01	0.180
p38MAPK events	R-HSA-171007	6.604893e-01	0.180
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	6.604893e-01	0.180
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	6.604893e-01	0.180
Other semaphorin interactions	R-HSA-416700	6.604893e-01	0.180
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.604893e-01	0.180
Neurotransmitter release cycle	R-HSA-112310	6.624312e-01	0.179
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	6.625566e-01	0.179
Uptake and actions of bacterial toxins	R-HSA-5339562	6.625566e-01	0.179
Effects of PIP2 hydrolysis	R-HSA-114508	6.632119e-01	0.178
Vpu mediated degradation of CD4	R-HSA-180534	6.632119e-01	0.178
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.632119e-01	0.178
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	6.632119e-01	0.178
FCGR3A-mediated phagocytosis	R-HSA-9664422	6.678930e-01	0.175
Leishmania phagocytosis	R-HSA-9664417	6.678930e-01	0.175
Parasite infection	R-HSA-9664407	6.678930e-01	0.175
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	6.763192e-01	0.170
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	6.763192e-01	0.170
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	6.763192e-01	0.170
Dual Incision in GG-NER	R-HSA-5696400	6.763192e-01	0.170
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	6.763192e-01	0.170
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.763192e-01	0.170
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.763192e-01	0.170
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	6.763192e-01	0.170
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	6.792652e-01	0.168
Class I peroxisomal membrane protein import	R-HSA-9603798	6.792652e-01	0.168
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	6.792652e-01	0.168
Negative regulation of FLT3	R-HSA-9706369	6.792652e-01	0.168
Attachment and Entry	R-HSA-9678110	6.792652e-01	0.168
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	6.890080e-01	0.162
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	6.890080e-01	0.162
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.890080e-01	0.162
Transferrin endocytosis and recycling	R-HSA-917977	6.890080e-01	0.162
Regulation of Apoptosis	R-HSA-169911	6.890080e-01	0.162
TCR signaling	R-HSA-202403	6.915119e-01	0.160
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.970037e-01	0.157
Glycine degradation	R-HSA-6783984	6.970037e-01	0.157
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	6.970037e-01	0.157
Disorders of Developmental Biology	R-HSA-9675151	6.970037e-01	0.157
Galactose catabolism	R-HSA-70370	6.970037e-01	0.157
Coenzyme A biosynthesis	R-HSA-196783	6.970037e-01	0.157
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.970037e-01	0.157
tRNA modification in the mitochondrion	R-HSA-6787450	6.970037e-01	0.157
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	6.970037e-01	0.157
G1/S-Specific Transcription	R-HSA-69205	7.012844e-01	0.154
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	7.012844e-01	0.154
RNA Polymerase III Transcription	R-HSA-74158	7.012844e-01	0.154
Vif-mediated degradation of APOBEC3G	R-HSA-180585	7.012844e-01	0.154
Glycosphingolipid transport	R-HSA-9845576	7.012844e-01	0.154
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.034944e-01	0.153
Collagen formation	R-HSA-1474290	7.034944e-01	0.153
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.112751e-01	0.148
Degradation of DVL	R-HSA-4641258	7.131554e-01	0.147
Degradation of AXIN	R-HSA-4641257	7.131554e-01	0.147
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	7.131554e-01	0.147
Ovarian tumor domain proteases	R-HSA-5689896	7.131554e-01	0.147
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.132328e-01	0.147
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.137622e-01	0.146
Sulfide oxidation to sulfate	R-HSA-1614517	7.137622e-01	0.146
PI3K events in ERBB2 signaling	R-HSA-1963642	7.137622e-01	0.146
Regulation of NPAS4 gene expression	R-HSA-9768759	7.137622e-01	0.146
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	7.137622e-01	0.146
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	7.137622e-01	0.146
Uptake and function of anthrax toxins	R-HSA-5210891	7.137622e-01	0.146
Replication of the SARS-CoV-2 genome	R-HSA-9694686	7.137622e-01	0.146
Early SARS-CoV-2 Infection Events	R-HSA-9772572	7.235642e-01	0.141
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	7.246281e-01	0.140
RIPK1-mediated regulated necrosis	R-HSA-5213460	7.246281e-01	0.140
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	7.271178e-01	0.138
Adipogenesis	R-HSA-9843745	7.289926e-01	0.137
Cardiac conduction	R-HSA-5576891	7.289926e-01	0.137
Innate Immune System	R-HSA-168249	7.294562e-01	0.137
RNA Polymerase III Transcription Termination	R-HSA-73980	7.295948e-01	0.137
G beta:gamma signalling through PLC beta	R-HSA-418217	7.295948e-01	0.137
PKA activation	R-HSA-163615	7.295948e-01	0.137
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	7.295948e-01	0.137
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	7.295948e-01	0.137
Presynaptic function of Kainate receptors	R-HSA-500657	7.295948e-01	0.137
PKA activation in glucagon signalling	R-HSA-164378	7.295948e-01	0.137
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	7.295948e-01	0.137
Polo-like kinase mediated events	R-HSA-156711	7.295948e-01	0.137
Telomere Maintenance	R-HSA-157579	7.337486e-01	0.134
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.338809e-01	0.134
Circadian clock	R-HSA-9909396	7.352778e-01	0.134
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	7.357104e-01	0.133
Signaling by ALK	R-HSA-201556	7.357104e-01	0.133
Interferon alpha/beta signaling	R-HSA-909733	7.405245e-01	0.130
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	7.418826e-01	0.130
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.418826e-01	0.130
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	7.436843e-01	0.129
PI-3K cascade:FGFR3	R-HSA-5654710	7.445525e-01	0.128
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.445525e-01	0.128
Germ layer formation at gastrulation	R-HSA-9754189	7.445525e-01	0.128
Signaling by FGFR2 IIIa TM	R-HSA-8851708	7.445525e-01	0.128
Pyrimidine biosynthesis	R-HSA-500753	7.445525e-01	0.128
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	7.445525e-01	0.128
Conjugation of carboxylic acids	R-HSA-159424	7.445525e-01	0.128
Amino Acid conjugation	R-HSA-156587	7.445525e-01	0.128
The NLRP3 inflammasome	R-HSA-844456	7.445525e-01	0.128
Methionine salvage pathway	R-HSA-1237112	7.445525e-01	0.128
Rap1 signalling	R-HSA-392517	7.445525e-01	0.128
Diseases of hemostasis	R-HSA-9671793	7.445525e-01	0.128
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	7.445525e-01	0.128
Maturation of nucleoprotein	R-HSA-9694631	7.445525e-01	0.128
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.445525e-01	0.128
Generation of second messenger molecules	R-HSA-202433	7.464102e-01	0.127
Negative regulation of NOTCH4 signaling	R-HSA-9604323	7.464102e-01	0.127
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	7.514009e-01	0.124
Toll-like Receptor Cascades	R-HSA-168898	7.533763e-01	0.123
ABC-family proteins mediated transport	R-HSA-382556	7.549231e-01	0.122
VEGFR2 mediated vascular permeability	R-HSA-5218920	7.567359e-01	0.121
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	7.567359e-01	0.121
FLT3 Signaling	R-HSA-9607240	7.567359e-01	0.121
PI-3K cascade:FGFR4	R-HSA-5654720	7.586837e-01	0.120
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.586837e-01	0.120
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.586837e-01	0.120
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.586837e-01	0.120
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.586837e-01	0.120
Formation of definitive endoderm	R-HSA-9823730	7.586837e-01	0.120
Signaling by NODAL	R-HSA-1181150	7.586837e-01	0.120
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	7.586837e-01	0.120
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.586837e-01	0.120
Acyl chain remodelling of PI	R-HSA-1482922	7.586837e-01	0.120
Pregnenolone biosynthesis	R-HSA-196108	7.586837e-01	0.120
Eicosanoid ligand-binding receptors	R-HSA-391903	7.586837e-01	0.120
Mitochondrial protein import	R-HSA-1268020	7.592223e-01	0.120
Heme signaling	R-HSA-9707616	7.592223e-01	0.120
Interleukin-1 signaling	R-HSA-9020702	7.616949e-01	0.118
Infectious disease	R-HSA-5663205	7.643568e-01	0.117
Degradation of CRY and PER proteins	R-HSA-9932298	7.666963e-01	0.115
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.666963e-01	0.115
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.666963e-01	0.115
G1/S DNA Damage Checkpoints	R-HSA-69615	7.675326e-01	0.115
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	7.708481e-01	0.113
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.720339e-01	0.112
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.720339e-01	0.112
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	7.720339e-01	0.112
Zygotic genome activation (ZGA)	R-HSA-9819196	7.720339e-01	0.112
Signalling to RAS	R-HSA-167044	7.720339e-01	0.112
Acyl chain remodelling of PG	R-HSA-1482925	7.720339e-01	0.112
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	7.763000e-01	0.110
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.804860e-01	0.108
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.846464e-01	0.105
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.846464e-01	0.105
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.846464e-01	0.105
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	7.846464e-01	0.105
Serine metabolism	R-HSA-977347	7.846464e-01	0.105
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.846464e-01	0.105
Attachment and Entry	R-HSA-9694614	7.846464e-01	0.105
Signaling by PDGFR in disease	R-HSA-9671555	7.846464e-01	0.105
Ribavirin ADME	R-HSA-9755088	7.846464e-01	0.105
Signaling by SCF-KIT	R-HSA-1433557	7.855560e-01	0.105
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	7.873204e-01	0.104
Regulation of T cell activation by CD28 family	R-HSA-388841	7.873380e-01	0.104
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	7.910665e-01	0.102
Proteasome assembly	R-HSA-9907900	7.944735e-01	0.100
Methylation	R-HSA-156581	7.944735e-01	0.100
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.965617e-01	0.099
WNT ligand biogenesis and trafficking	R-HSA-3238698	7.965617e-01	0.099
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.965617e-01	0.099
LDL clearance	R-HSA-8964038	7.965617e-01	0.099
Fructose metabolism	R-HSA-5652084	7.965617e-01	0.099
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.965617e-01	0.099
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	7.965617e-01	0.099
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.965617e-01	0.099
Kidney development	R-HSA-9830369	7.984578e-01	0.098
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	8.030615e-01	0.095
Asymmetric localization of PCP proteins	R-HSA-4608870	8.030615e-01	0.095
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.030615e-01	0.095
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.030615e-01	0.095
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.030615e-01	0.095
Somitogenesis	R-HSA-9824272	8.030615e-01	0.095
Free fatty acids regulate insulin secretion	R-HSA-400451	8.078185e-01	0.093
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	8.078185e-01	0.093
Formation of the ureteric bud	R-HSA-9830674	8.078185e-01	0.093
Mitochondrial mRNA modification	R-HSA-9937008	8.078185e-01	0.093
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.113291e-01	0.091
Diseases of DNA repair	R-HSA-9675135	8.113291e-01	0.091
Downstream TCR signaling	R-HSA-202424	8.129703e-01	0.090
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.184531e-01	0.087
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	8.184531e-01	0.087
TRAF6 mediated NF-kB activation	R-HSA-933542	8.184531e-01	0.087
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.184531e-01	0.087
CD209 (DC-SIGN) signaling	R-HSA-5621575	8.184531e-01	0.087
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	8.184531e-01	0.087
Plasma lipoprotein assembly	R-HSA-8963898	8.184531e-01	0.087
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.184531e-01	0.087
Complex III assembly	R-HSA-9865881	8.184531e-01	0.087
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	8.184531e-01	0.087
Neurodegenerative Diseases	R-HSA-8863678	8.184531e-01	0.087
Interleukin-6 family signaling	R-HSA-6783589	8.184531e-01	0.087
Synthesis of PC	R-HSA-1483191	8.192856e-01	0.087
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	8.258633e-01	0.083
Asparagine N-linked glycosylation	R-HSA-446203	8.268960e-01	0.083
GPER1 signaling	R-HSA-9634597	8.269399e-01	0.083
Plasma lipoprotein remodeling	R-HSA-8963899	8.269399e-01	0.083
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	8.269399e-01	0.083
PI-3K cascade:FGFR2	R-HSA-5654695	8.284998e-01	0.082
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	8.284998e-01	0.082
Tight junction interactions	R-HSA-420029	8.284998e-01	0.082
MicroRNA (miRNA) biogenesis	R-HSA-203927	8.284998e-01	0.082
TGFBR3 expression	R-HSA-9839394	8.284998e-01	0.082
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	8.379911e-01	0.077
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.379911e-01	0.077
Suppression of phagosomal maturation	R-HSA-9637687	8.379911e-01	0.077
Ca2+ pathway	R-HSA-4086398	8.383294e-01	0.077
Regulation of RAS by GAPs	R-HSA-5658442	8.413785e-01	0.075
Signaling by FGFR2 in disease	R-HSA-5655253	8.413785e-01	0.075
Extracellular matrix organization	R-HSA-1474244	8.434429e-01	0.074
RNA Polymerase I Promoter Opening	R-HSA-73728	8.469576e-01	0.072
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.469576e-01	0.072
EPHA-mediated growth cone collapse	R-HSA-3928663	8.469576e-01	0.072
Signaling by FGFR3 in disease	R-HSA-5655332	8.469576e-01	0.072
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.469576e-01	0.072
Insulin processing	R-HSA-264876	8.469576e-01	0.072
Signaling by BMP	R-HSA-201451	8.469576e-01	0.072
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.469576e-01	0.072
Maturation of hRSV A proteins	R-HSA-9828806	8.469576e-01	0.072
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	8.469576e-01	0.072
Complex IV assembly	R-HSA-9864848	8.481805e-01	0.072
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.481805e-01	0.072
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.482949e-01	0.071
Regulation of PD-L1(CD274) expression	R-HSA-9909648	8.486179e-01	0.071
Iron uptake and transport	R-HSA-917937	8.500173e-01	0.071
RNA Polymerase I Promoter Escape	R-HSA-73772	8.547162e-01	0.068
Telomere Extension By Telomerase	R-HSA-171319	8.554284e-01	0.068
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.554284e-01	0.068
Inflammasomes	R-HSA-622312	8.554284e-01	0.068
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.566656e-01	0.067
CLEC7A (Dectin-1) signaling	R-HSA-5607764	8.566656e-01	0.067
Meiotic synapsis	R-HSA-1221632	8.609940e-01	0.065
Nucleotide biosynthesis	R-HSA-8956320	8.609940e-01	0.065
Late endosomal microautophagy	R-HSA-9615710	8.634309e-01	0.064
Downstream signaling of activated FGFR3	R-HSA-5654708	8.634309e-01	0.064
Regulation of CDH11 Expression and Function	R-HSA-9759475	8.634309e-01	0.064
Regulation of insulin secretion	R-HSA-422356	8.661271e-01	0.062
Integrin cell surface interactions	R-HSA-216083	8.661678e-01	0.062
ABC transporter disorders	R-HSA-5619084	8.661678e-01	0.062
HCMV Late Events	R-HSA-9610379	8.676612e-01	0.062
DAP12 signaling	R-HSA-2424491	8.709908e-01	0.060
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.709908e-01	0.060
Downstream signaling of activated FGFR4	R-HSA-5654716	8.709908e-01	0.060
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.709908e-01	0.060
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.709908e-01	0.060
Paracetamol ADME	R-HSA-9753281	8.728102e-01	0.059
Co-inhibition by PD-1	R-HSA-389948	8.736704e-01	0.059
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	8.760653e-01	0.057
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.781327e-01	0.056
Budding and maturation of HIV virion	R-HSA-162588	8.781327e-01	0.056
Molecules associated with elastic fibres	R-HSA-2129379	8.781327e-01	0.056
Evasion by RSV of host interferon responses	R-HSA-9833109	8.781327e-01	0.056
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.781327e-01	0.056
Disease	R-HSA-1643685	8.824660e-01	0.054
Synthesis of PA	R-HSA-1483166	8.836953e-01	0.054
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.848796e-01	0.053
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.888086e-01	0.051
Cytoprotection by HMOX1	R-HSA-9707564	8.896950e-01	0.051
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	8.912534e-01	0.050
Nuclear RNA decay	R-HSA-9930044	8.912534e-01	0.050
Assembly of the ORC complex at the origin of replication	R-HSA-68616	8.912534e-01	0.050
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	8.912534e-01	0.050
Cardiogenesis	R-HSA-9733709	8.912534e-01	0.050
Recycling of bile acids and salts	R-HSA-159418	8.912534e-01	0.050
Formation of the cornified envelope	R-HSA-6809371	8.919412e-01	0.050
Peroxisomal protein import	R-HSA-9033241	8.937126e-01	0.049
Resolution of D-Loop Structures	R-HSA-5693537	8.972746e-01	0.047
Acyl chain remodelling of PC	R-HSA-1482788	8.972746e-01	0.047
Glucagon signaling in metabolic regulation	R-HSA-163359	8.972746e-01	0.047
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.972746e-01	0.047
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.972746e-01	0.047
Miscellaneous transport and binding events	R-HSA-5223345	8.972746e-01	0.047
RAB geranylgeranylation	R-HSA-8873719	8.984149e-01	0.047
Metabolism of polyamines	R-HSA-351202	8.984149e-01	0.047
Collagen degradation	R-HSA-1442490	9.029228e-01	0.044
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.029228e-01	0.044
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	9.029628e-01	0.044
eNOS activation	R-HSA-203615	9.029628e-01	0.044
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.029628e-01	0.044
NOD1/2 Signaling Pathway	R-HSA-168638	9.029628e-01	0.044
Signal amplification	R-HSA-392518	9.029628e-01	0.044
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.057759e-01	0.043
Signaling by PDGF	R-HSA-186797	9.072433e-01	0.042
Downstream signaling of activated FGFR2	R-HSA-5654696	9.083364e-01	0.042
Acyl chain remodelling of PE	R-HSA-1482839	9.083364e-01	0.042
tRNA processing	R-HSA-72306	9.113056e-01	0.040
GPVI-mediated activation cascade	R-HSA-114604	9.134127e-01	0.039
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.134127e-01	0.039
FGFR2 mutant receptor activation	R-HSA-1839126	9.134127e-01	0.039
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.153498e-01	0.038
Voltage gated Potassium channels	R-HSA-1296072	9.182081e-01	0.037
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.182081e-01	0.037
Collagen chain trimerization	R-HSA-8948216	9.182081e-01	0.037
Metabolism of folate and pterines	R-HSA-196757	9.182081e-01	0.037
Base Excision Repair	R-HSA-73884	9.197056e-01	0.036
Parasitic Infection Pathways	R-HSA-9824443	9.208978e-01	0.036
Leishmania infection	R-HSA-9658195	9.208978e-01	0.036
Post-translational protein modification	R-HSA-597592	9.217173e-01	0.035
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.227383e-01	0.035
Elastic fibre formation	R-HSA-1566948	9.227383e-01	0.035
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.227383e-01	0.035
Plasma lipoprotein clearance	R-HSA-8964043	9.270178e-01	0.033
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.288898e-01	0.032
Neddylation	R-HSA-8951664	9.294790e-01	0.032
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.296061e-01	0.032
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	9.296061e-01	0.032
Regulated Necrosis	R-HSA-5218859	9.296061e-01	0.032
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.310605e-01	0.031
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.310605e-01	0.031
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.310605e-01	0.031
Diseases of Immune System	R-HSA-5260271	9.310605e-01	0.031
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.310605e-01	0.031
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.310605e-01	0.031
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.310605e-01	0.031
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	9.348795e-01	0.029
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.348795e-01	0.029
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.358528e-01	0.029
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.384871e-01	0.028
HIV Transcription Initiation	R-HSA-167161	9.384871e-01	0.028
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.384871e-01	0.028
Scavenging by Class A Receptors	R-HSA-3000480	9.384871e-01	0.028
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.384871e-01	0.028
Translation of Structural Proteins	R-HSA-9683701	9.384871e-01	0.028
Mitochondrial biogenesis	R-HSA-1592230	9.393527e-01	0.027
Cytosolic tRNA aminoacylation	R-HSA-379716	9.418951e-01	0.026
Aspirin ADME	R-HSA-9749641	9.442460e-01	0.025
RNA Polymerase II Promoter Escape	R-HSA-73776	9.451145e-01	0.025
DAP12 interactions	R-HSA-2172127	9.481557e-01	0.023
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.481557e-01	0.023
Citric acid cycle (TCA cycle)	R-HSA-71403	9.492492e-01	0.023
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.492492e-01	0.023
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.510285e-01	0.022
Fanconi Anemia Pathway	R-HSA-6783310	9.510285e-01	0.022
Degradation of cysteine and homocysteine	R-HSA-1614558	9.510285e-01	0.022
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.510285e-01	0.022
Condensation of Prophase Chromosomes	R-HSA-2299718	9.537424e-01	0.021
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.537424e-01	0.021
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.537424e-01	0.021
Regulation of pyruvate metabolism	R-HSA-9861718	9.537424e-01	0.021
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.537424e-01	0.021
Regulation of TNFR1 signaling	R-HSA-5357905	9.537424e-01	0.021
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.538224e-01	0.021
Metabolism of nucleotides	R-HSA-15869	9.539872e-01	0.020
Nuclear Receptor transcription pathway	R-HSA-383280	9.559586e-01	0.020
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.563059e-01	0.019
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.585811e-01	0.018
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	9.602669e-01	0.018
Activation of HOX genes during differentiation	R-HSA-5619507	9.602669e-01	0.018
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.610152e-01	0.017
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.610152e-01	0.017
Chemokine receptors bind chemokines	R-HSA-380108	9.610152e-01	0.017
Interleukin-1 family signaling	R-HSA-446652	9.643018e-01	0.016
The phototransduction cascade	R-HSA-2514856	9.652174e-01	0.015
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.652948e-01	0.015
Meiosis	R-HSA-1500620	9.684692e-01	0.014
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.684717e-01	0.014
Glycerophospholipid biosynthesis	R-HSA-1483206	9.684717e-01	0.014
Amino acids regulate mTORC1	R-HSA-9639288	9.689671e-01	0.014
Bile acid and bile salt metabolism	R-HSA-194068	9.692504e-01	0.014
Sulfur amino acid metabolism	R-HSA-1614635	9.713631e-01	0.013
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.713777e-01	0.013
FCERI mediated MAPK activation	R-HSA-2871796	9.717918e-01	0.012
G alpha (z) signalling events	R-HSA-418597	9.723129e-01	0.012
Pyruvate metabolism	R-HSA-70268	9.727122e-01	0.012
TNF signaling	R-HSA-75893	9.738481e-01	0.012
GPCR downstream signalling	R-HSA-388396	9.776452e-01	0.010
Amino acid transport across the plasma membrane	R-HSA-352230	9.779622e-01	0.010
Cell surface interactions at the vascular wall	R-HSA-202733	9.781906e-01	0.010
tRNA Aminoacylation	R-HSA-379724	9.791845e-01	0.009
SLC transporter disorders	R-HSA-5619102	9.795893e-01	0.009
Aquaporin-mediated transport	R-HSA-445717	9.803391e-01	0.009
G alpha (q) signalling events	R-HSA-416476	9.804021e-01	0.009
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.814297e-01	0.008
Mitochondrial protein degradation	R-HSA-9837999	9.815038e-01	0.008
Complex I biogenesis	R-HSA-6799198	9.824598e-01	0.008
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.825669e-01	0.008
C-type lectin receptors (CLRs)	R-HSA-5621481	9.831406e-01	0.007
G alpha (s) signalling events	R-HSA-418555	9.831406e-01	0.007
G alpha (i) signalling events	R-HSA-418594	9.839807e-01	0.007
Disorders of transmembrane transporters	R-HSA-5619115	9.843327e-01	0.007
SLC-mediated transport of amino acids	R-HSA-9958863	9.860403e-01	0.006
Metabolism of steroid hormones	R-HSA-196071	9.860403e-01	0.006
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	9.860415e-01	0.006
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	9.860415e-01	0.006
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	9.860415e-01	0.006
Synthesis of bile acids and bile salts	R-HSA-192105	9.862246e-01	0.006
Respiratory electron transport	R-HSA-611105	9.871472e-01	0.006
ECM proteoglycans	R-HSA-3000178	9.888906e-01	0.005
Metabolism of cofactors	R-HSA-8978934	9.888906e-01	0.005
Purine catabolism	R-HSA-74259	9.895072e-01	0.005
RSV-host interactions	R-HSA-9833110	9.897644e-01	0.004
Metabolism of proteins	R-HSA-392499	9.897977e-01	0.004
ROS and RNS production in phagocytes	R-HSA-1222556	9.906398e-01	0.004
Translation of Structural Proteins	R-HSA-9694635	9.921138e-01	0.003
Antimicrobial peptides	R-HSA-6803157	9.927815e-01	0.003
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.929652e-01	0.003
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.929652e-01	0.003
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.946602e-01	0.002
Role of phospholipids in phagocytosis	R-HSA-2029485	9.946602e-01	0.002
FCERI mediated NF-kB activation	R-HSA-2871837	9.948685e-01	0.002
Leishmania parasite growth and survival	R-HSA-9664433	9.949235e-01	0.002
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.949235e-01	0.002
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.952327e-01	0.002
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.959457e-01	0.002
Keratinization	R-HSA-6805567	9.959938e-01	0.002
Diseases of programmed cell death	R-HSA-9645723	9.960276e-01	0.002
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.961162e-01	0.002
Signaling by GPCR	R-HSA-372790	9.962382e-01	0.002
Class B/2 (Secretin family receptors)	R-HSA-373080	9.964568e-01	0.002
PPARA activates gene expression	R-HSA-1989781	9.969260e-01	0.001
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.970153e-01	0.001
Phospholipid metabolism	R-HSA-1483257	9.971193e-01	0.001
FCGR activation	R-HSA-2029481	9.971812e-01	0.001
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.971812e-01	0.001
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.972016e-01	0.001
Drug ADME	R-HSA-9748784	9.975694e-01	0.001
Reproduction	R-HSA-1474165	9.977484e-01	0.001
Potassium Channels	R-HSA-1296071	9.977576e-01	0.001
Degradation of the extracellular matrix	R-HSA-1474228	9.979675e-01	0.001
Metabolism of amino acids and derivatives	R-HSA-71291	9.980146e-01	0.001
PI Metabolism	R-HSA-1483255	9.984092e-01	0.001
Arachidonate metabolism	R-HSA-2142753	9.993477e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.994324e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.995042e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.996792e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.997306e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.998963e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999192e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999540e-01	0.000
Transport of small molecules	R-HSA-382551	9.999571e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999787e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999819e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999907e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999964e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999999e-01	0.000
Fatty acid metabolism	R-HSA-8978868	9.999999e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000