PKN1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00116 T68 Sugiyama AGPS AAG5 RPREALSTNECKARRAAsAAtAAPtAtPAAQEsGtIPKKRQ
O00273 S28 Sugiyama DFFA DFF1 DFF45 H13 GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O14617 S658 Sugiyama AP3D1 PRO0039 DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14965 S342 EPSD AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 FLVGKPPFEANTYQETYKRIsRVEFTFPDFVTEGARDLISR
O14965 T288 EPSD AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 GELKIADFGWsVHAPssRRttLCGTLDYLPPEMIEGRMHDE
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15067 S215 Sugiyama PFAS KIAA0361 LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15067 T216 Sugiyama PFAS KIAA0361 DSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFFK
O15143 T21 EPSD ARPC1B ARC41 MAYHSFLVEPISCHAWNKDRtQIAICPNNHEVHIyEKSGAK
O15553 S208 SIGNOR|EPSD|PSP MEFV MEF TRIM20 PGPCRALEGGQAEVRLRRNAssAGRLQGLAGGAPGQKECRP
O15553 S242 SIGNOR|EPSD|PSP MEFV MEF TRIM20 GQKECRPFEVYLPSGKMRPRsLEVTISTGEKAPANPEILLT
O43615 S193 Sugiyama TIMM44 MIMT44 TIM44 TAAFRALsQGVEsVKKEIDDsVLGQtGPyRRPQRLRKRTEF
O43623 S251 EPSD SNAI2 SLUG SLUGH HLQTHsDVKKYQCKNCsKTFsRMsLLHKHEESGCCVAH___
O43823 S125 Sugiyama AKAP8 AKAP95 KEGGRGGsGGGGEGIQDREssFRFQPFESYDSRPCLPEHNP
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95863 S246 SIGNOR|EPSD SNAI1 SNAH HLQTHsDVKKYQCQACARTFsRMsLLHKHQESGCSGCPR__
P00533 T678 SIGNOR|EPSD|PSP EGFR ERBB ERBB1 HER1 LVVALGIGLFMRRRHIVRKRtLRRLLQERELVEPLtPsGEA
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P03372 S305 EPSD ESR1 ESR NR3A1 DMRAANLWPsPLMIKRSKKNsLALSLtADQMVSALLDAEPP
P04049 S338 SIGNOR|EPSD RAF1 RAF RAPVsGtQEKNKIRPRGQRDssyyWEIEASEVMLSTRIGsG
P04049 S339 SIGNOR|EPSD RAF1 RAF APVsGtQEKNKIRPRGQRDssyyWEIEASEVMLSTRIGsGs
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792 S83 Sugiyama HSPB1 HSP27 HSP28 IEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNH
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05783 S93 Sugiyama KRT18 CYK18 PIG46 GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787 S410 Sugiyama KRT8 CYK8 TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL
P06899 S37 Sugiyama H2BC11 H2BFR HIST1H2BJ KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P06899 S39 Sugiyama H2BC11 H2BFR HIST1H2BJ VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07737 S57 Sugiyama PFN1 GKtFVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDs
P07737 S58 Sugiyama PFN1 KtFVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsL
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08670 S51 EPSD VIM VttsTRtYsLGsALRPstsRsLyAssPGGVyAtRssAVRLR
P08670 S56 EPSD VIM RtYsLGsALRPstsRsLyAssPGGVyAtRssAVRLRssVPG
P08670 S73 EPSD VIM yAssPGGVyAtRssAVRLRssVPGVRLLQDsVDFsLADAIN
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0C0L4 S1294 Sugiyama C4A CO4 CPAMD2 LHEGKAEMADQASAWLTRQGsFQGGFRSTQDTVIALDALSA
P0C0L5 S1294 Sugiyama C4B CO4 CPAMD3; C4B_2 LHEGKAEMADQAAAWLTRQGsFQGGFRSTQDTVIALDALSA
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10636 S214 EPSD MAPT MAPTL MTBT1 TAU GDLHQEGPPLKGAGGKERPGsKEEVDEDRDVDESsPQDsPP
P10636 S531 EPSD MAPT MAPTL MTBT1 TAU RsGyssPGsPGtPGsRsRtPsLPtPPTREPKKVAVVRtPPK
P10636 S575 EPSD MAPT MAPTL MTBT1 TAU sAKSRLQTAPVPMPDLKNVKsKIGstENLKHQPGGGKVQII
P10636 S637 SIGNOR|EPSD MAPT MAPTL MTBT1 TAU VPGGGsVQIVyKPVDLSKVTsKCGsLGNIHHKPGGGQVEVK
P10636 S669 EPSD MAPT MAPTL MTBT1 TAU PGGGQVEVKSEKLDFKDRVQsKIGsLDNITHVPGGGNKKIE
P11142 S340 Sugiyama HSPA8 HSC70 HSP73 HSPA10 ALRDAKLDKsQIHDIVLVGGstRIPKIQKLLQDFFNGKELN
P11532 S3623 Sugiyama DMD EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13667 S126 Sugiyama PDIA4 ERP70 ERP72 NILKDKDPPIPVAKIDAtsAsVLAsRFDVsGyPtIKILKKG
P13797 S339 Sugiyama PLS3 PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S514 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625 T519 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 DHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIy
P15056 S446 EPSD BRAF BRAF1 RAFB1 RKsssssEDRNRMKtLGRRDssDDWEIPDGQITVGQRIGsG
P15880 S190 Sugiyama RPS2 RPS4 WGNKIGKPHTVPCKVTGRCGsVLVRLIPAPRGtGIVsAPVP
P16949 S16 EPSD STMN1 C1orf215 LAP18 OP18 _____MAssDIQVKELEKRAsGQAFELILsPRsKEsVPEFP
P16949 S38 EPSD STMN1 C1orf215 LAP18 OP18 QAFELILsPRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAE
P17600 S605 EPSD SYN1 QQRQGPPQKPPGPAGPTRQAsQAGPVPRTGPPTTQQPRPSG
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P17987 S374 Sugiyama TCP1 CCT1 CCTA ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18669 S118 SIGNOR|EPSD PGAM1 PGAMA CDABP0006 LNKAETAAKHGEAQVKIWRRsyDVPPPPMEPDHPFysNIsK
P18669 S23 SIGNOR|EPSD PGAM1 PGAMA CDABP0006 AYKLVLIRHGEsAWNLENRFsGWyDADLsPAGHEEAKRGGQ
P19086 S16 EPSD GNAZ _____MGCRQSSEEKEAARRsRRIDRHLRSEsQRQRREIKL
P19338 S328 Sugiyama NCL NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20618 S162 Sugiyama PSMB1 PSC5 DEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLDNQVG
P21333 S2152 EPSD FLNA FLN FLN1 VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P21333 S2292 EPSD FLNA FLN FLN1 AIAVEGPsKAEIsFEDRKDGsCGVAyVVQEPGDyEVsVKFN
P21333 S2370 EPSD FLNA FLN FLN1 PASFAVSLNGAKGAIDAKVHsPsGALEECyVtEIDQDKYAV
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23246 S283 Sugiyama SFPQ PSF GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23527 S37 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P23527 S39 Sugiyama H2BC17 H2BFH H2BFN HIST1H2BO VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P24844 S20 EPSD MYL9 MLC2 MRLC1 MYRL2 _MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P25789 S7 Sugiyama PSMA4 HC9 PSC9 ______________MSRRyDsRttIFsPEGRLYQVEYAMEA
P25789 T9 Sugiyama PSMA4 HC9 PSC9 ____________MSRRyDsRttIFsPEGRLYQVEYAMEAIG
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27816 S827 Sugiyama MAP4 VAKtttAAAVAstGPssRsPstLLPKKPTAIKTEGKPAEVK
P29466 S376 EPSD CASP1 IL1BC IL1BCE HMQEYACSCDVEEIFRKVRFsFEQPDGRAQMPTTERVTLTR
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29966 S159 SIGNOR|iPTMNet|EPSD MARCKS MACS PRKCSL EDGAtPsPsNEtPKKKKKRFsFKKsFKLsGFsFKKNKKEAG
P29966 S163 SIGNOR|iPTMNet|EPSD MARCKS MACS PRKCSL tPsPsNEtPKKKKKRFsFKKsFKLsGFsFKKNKKEAGEGGE
P29966 S170 SIGNOR|iPTMNet|EPSD MARCKS MACS PRKCSL tPKKKKKRFsFKKsFKLsGFsFKKNKKEAGEGGEAEAPAAE
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30307 S216 SIGNOR|iPTMNet|EPSD CDC25C EFsLKDQEAKVSRsGLYRsPsMPENLNRPRLKQVEKFKDNt
P30622 S312 EPSD|PSP CLIP1 CYLN1 RSN KANAVRRVMATtsAsLKRsPsAssLsSMSSVASSVSSRPSR
P31152 S186 EPSD MAPK4 ERK4 PRKM4 IGDFGLARIVDQHYSHKGYLsEGLVTKWYRsPRLLLSPNNY
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P32969 Y180 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P33778 S37 Sugiyama H2BC3 H2BFF HIST1H2BB KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P33778 S39 Sugiyama H2BC3 H2BFF HIST1H2BB ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P35222 S675 EPSD CTNNB1 CTNNB OK/SW-cl.35 PRO2286 AAAVLFRMSEDKPQDyKKRLsVELtssLFRTEPMAWNETAD
P35240 S518 EPSD NF2 SCH FNLIGDSLSFDFKDTDMKRLsMEIEKEKVEYMEKSKHLQEQ
P35579 S1915 Sugiyama MYH9 KLQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMA
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578 S87 Sugiyama RPL4 RPL1 WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578 T84 Sugiyama RPL4 RPL1 AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P36871 T467 SIGNOR|EPSD PGM1 ALMFDRSFVGKQFSANDKVYtVEKADNFEysDPVDGsIsRN
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38606 S384 Sugiyama ATP6V1A ATP6A1 ATP6V1A1 VPP2 RLAEMPADSGYPAyLGARLAsFYERAGRVKCLGNPEREGSV
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P42677 S78 Sugiyama RPS27 MPS1 GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490 S472 Sugiyama NAMPT PBEF PBEF1 EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46108 S41 EPSD CRK QEAVALLQGQRHGVFLVRDsstsPGDyVLSVSENSRVSHYI
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S176 Sugiyama RPL5 MSTP030 GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P47914 Y98 Sugiyama RPL29 PKEVKPKIPKGVSRKLDRLAyIAHPKLGKRARARIAKGLRL
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P49023 S258 EPSD PXN NQGEMssPQRVTsTQQQtRIsAssAtRELDELMAsLsDFKI
P49023 S272 EPSD PXN QQQtRIsAssAtRELDELMAsLsDFKIQGLEQRADGERCWA
P49588 S775 Sugiyama AARS1 AARS VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P50395 T425 Sugiyama GDI2 RABGDIB DAttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED
P51114 S420 EPSD FXR1 GtNsELsNPsEtEsERKDELsDWsLAGEDDRDsRHQRDSRR
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51532 S1382 Sugiyama SMARCA4 BAF190A BRG1 SNF2B SNF2L4 EEEKMFGRGSRHRKEVDYsDsLTEKQWLKAIEEGtLEEIEE
P51991 S375 Sugiyama HNRNPA3 HNRPA3 ssGsPyGGGyGsGGGsGGyGsRRF_________________
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52565 S101 EPSD ARHGDIA GDIA1 SAPGPLELDLtGDLEsFKKQsFVLKEGVEYRIKISFRVNRE
P52565 S174 EPSD ARHGDIA GDIA1 EEyEFLtPVEEAPKGMLARGsYsIKSRFTDDDKTDHLSWEW
P53350 S49 EPSD PLK1 PLK GAPAAAPPAKEIPEVLVDPRsRRRYVRGRFLGKGGFAKCFE
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53667 T508 EPSD LIMK1 LIMK EKTQPEGLRSLKKPDRKKRYtVVGNPyWMAPEMINGRSYDE
P55010 S10 Sugiyama EIF5 ___________MSVNVNRsVsDQFyRyKMPRLIAKVEGKGN
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58012 S263 EPSD FOXL2 AVVKGLAGPAASYGPyTRVQsMALPPGVVNSYNGLGGPPAA
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P60900 S177 Sugiyama PSMA6 PROS27 AGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTVET
P61254 S31 Sugiyama RPL26 RsKNRKRHFNAPsHIRRKIMssPLSKELRQKYNVRSMPIRK
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61313 Y6 Sugiyama RPL15 EC45 TCBAP0781 _______________MGAYKyIQELWRKKQSDVMRFLLRVR
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263 S139 Sugiyama RPS14 PRO2640 LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62266 S45 Sugiyama RPS23 KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62701 T247 Sugiyama RPS4X CCG2 RPS4 SCAR VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62899 S15 Sugiyama RPL31 ______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63167 S88 EPSD DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 HETKHFIYFYLGQVAILLFKsG___________________
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 Y196 Sugiyama YBX1 NSEP1 YB1 sAPEGQAQQRRPyRRRRFPPyyMRRPYGRRPQysNPPVQGE
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68431 S11 EPSD H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J __________MARtKQtARKstGGKAPRKQLATKAARKsAP
P68431 T12 EPSD H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J _________MARtKQtARKstGGKAPRKQLATKAARKsAPA
P78545 S207 EPSD ELF3 ERT ESX JEN GAPSPGSSDVSTAGTGASRSsHSsDsGGsDVDLDPTDGKLF
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098 S122 Sugiyama RPL19 LRRLLRRYRESKKIDRHMyHsLyLKVKGNVFKNKRILMEHI
P84098 S13 Sugiyama RPL19 ________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEIA
Q00341 S904 Sugiyama HDLBP HBP VGL FHRSVMGPKGSRIQQITRDFsVQIKFPDREENAVHSTEPVV
Q00587 S192 Sugiyama CDC42EP1 BORG5 CEP1 MSE55 PHDRDRDGsFPsEPGLRRsDsLLsFRLDLDLGPSLLSELLG
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q02750 S298 EPSD MAP2K1 MEK1 PRKMK1 QVEGDAAEtPPRPRtPGRPLssyGMDsRPPMAIFELLDYIV
Q02878 T213 Sugiyama RPL6 TXREB1 FVIAtsTKIDISNVKIPKHLtDAyFKKKKLRKPRHQEGEIF
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q12778 S256 SIGNOR|EPSD FOXO1 FKHR FOXO1A WWMLNPEGGKSGKsPRRRAAsMDNNSKFAKSRSRAAKKKAs
Q12965 T936 Sugiyama MYO1E MYO1C LQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAP
Q13153 S144 EPSD PAK1 VLDVLEFYNsKKTSNSQKYMsFtDKsAEDyNssNALNVKAV
Q13153 S149 EPSD PAK1 EFYNsKKTSNSQKYMsFtDKsAEDyNssNALNVKAVsETPA
Q13153 S165 EPSD PAK1 FtDKsAEDyNssNALNVKAVsETPAVPPVsEDEDDDDDDAt
Q13153 S199 EPSD PAK1 DDDDDAtPPPVIAPRPEHTKsVytRsVIEPLPVtPtRDVAt
Q13153 S204 EPSD PAK1 AtPPPVIAPRPEHTKsVytRsVIEPLPVtPtRDVAtsPIsP
Q13153 S21 EPSD PAK1 MsNNGLDIQDKPPAPPMRNTsTMIGAGSKDAGTLNHGSKPL
Q13153 S57 EPSD PAK1 GSKPLPPNPEEKKKKDRFYRsILPGDKTNKKKEKERPEISL
Q13153 T423 EPSD PAK1 VKLTDFGFCAQITPEQSKRstMVGTPYWMAPEVVTRKAYGP
Q13233 S67 EPSD MAP3K1 MAPKKK1 MEKK MEKK1 AGSGGRERADWRRRQLRKVRsVELDQLPEQPLFLAASPPAS
Q13263 S473 Sugiyama TRIM28 KAP1 RNF96 TIF1B sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13352 S28 EPSD ITGB3BP CENPR NRIF3 KLDGLLEENsFDPSKITRKKsVItYsPttGtCQMsLFAsPT
Q13363 S158 EPSD CTBP1 CTBP NLYRRAtWLHQALREGTRVQsVEQIREVASGAARIRGETLG
Q13418 S246 EPSD ILK ILK1 ILK2 DWSTRKsRDFNEECPRLRIFsHPNVLPVLGACQSPPAPHPT
Q13418 T173 EPSD ILK ILK1 ILK2 EKMGQNLNRIPYKDTFWKGttRTRPRNGtLNKHsGIDFKQL
Q13761 T209 EPSD RUNX3 AML2 CBFA3 PEBP2A3 DQTKPFPDRFGDLERLRMRVtPstPsPRGsLsttsHFssQP
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152 S988 Sugiyama EIF3A EIF3S10 KIAA0139 PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14247 S405 EPSD CTTN EMS1 EEARRKLEEQARAKtQtPPVsPAPQPtEERLPssPVyEDAA
Q14247 S418 EPSD CTTN EMS1 KtQtPPVsPAPQPtEERLPssPVyEDAAsFKAELsyRGPVs
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15365 T127 EPSD PCBP1 TQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15365 T60 EPSD PCBP1 REEsGARINIsEGNCPERIItLTGPTNAIFKAFAMIIDKLE
Q15746 S1772 EPSD MYLK MLCK MLCK1 MYLK1 VRAIGRLssMAMISGLSGRKsstGsPtsPLNAEKLEsEEDV
Q15746 S18 EPSD MYLK MLCK MLCK1 MYLK1 ___MGDVKLVASSHIsKTsLsVDPSRVDSMPLTEAPAFILP
Q16512 S156 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 AIELKVKQGAENMIQTYSNGsTKDRKLLLTAQQMLQDSKTK
Q16512 S205 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 RRALQAGQLENQAAPDDtQGsPDLGAVELRIEELRHHFRVE
Q16512 S296 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 GELPADHPKGRLLREELAAAssAAFstRLAGPFPATHYSTL
Q16512 S297 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 ELPADHPKGRLLREELAAAssAAFstRLAGPFPATHYSTLC
Q16512 S301 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 DHPKGRLLREELAAAssAAFstRLAGPFPATHYSTLCKPAP
Q16512 S372 EPSD|Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 GtPDSRPPFLSRPARGLYSRsGsLsGRssLKAEAENTSEVS
Q16512 S374 SIGNOR|EPSD|Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 PDSRPPFLSRPARGLYSRsGsLsGRssLKAEAENTSEVSTV
Q16512 S376 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 SRPPFLSRPARGLYSRsGsLsGRssLKAEAENTSEVSTVLK
Q16512 S380 EPSD PKN1 PAK1 PKN PRK1 PRKCL1 FLSRPARGLYSRsGsLsGRssLKAEAENTSEVSTVLKLDNT
Q16512 S533 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 ATWVRLLRRLIPNAtGtGtFsPGAsPGsEARTTGDIsVEKL
Q16512 S537 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 RLLRRLIPNAtGtGtFsPGAsPGsEARTTGDIsVEKLNLGt
Q16512 S559 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 GsEARTTGDIsVEKLNLGtDsDssPQKssRDPPssPssLss
Q16512 S561 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 EARTTGDIsVEKLNLGtDsDssPQKssRDPPssPssLssPI
Q16512 S562 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 ARTTGDIsVEKLNLGtDsDssPQKssRDPPssPssLssPIQ
Q16512 S576 EPSD PKN1 PAK1 PKN PRK1 PRKCL1 GtDsDssPQKssRDPPssPssLssPIQEstAPELPsEtQEt
Q16512 S608 EPSD PKN1 PAK1 PKN PRK1 PRKCL1 ELPsEtQEtPGPALCsPLRKsPLtLEDFKFLAVLGRGHFGK
Q16512 S69 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 ELKLKEGAENLRRAttDLGRsLGPVELLLRGSSRRLDLLHQ
Q16512 T202 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 MQLRRALQAGQLENQAAPDDtQGsPDLGAVELRIEELRHHF
Q16512 T531 SIGNOR|EPSD PKN1 PAK1 PKN PRK1 PRKCL1 DVATWVRLLRRLIPNAtGtGtFsPGAsPGsEARTTGDIsVE
Q16512 T63 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 RREIRKELKLKEGAENLRRAttDLGRsLGPVELLLRGSSRR
Q16512 T64 SIGNOR|EPSD|Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 REIRKELKLKEGAENLRRAttDLGRsLGPVELLLRGSSRRL
Q16512 T774 EPSD|PSP|Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 VKIADFGLCKEGMGyGDRtstFCGtPEFLAPEVLTDTSYTR
Q16512 T778 Sugiyama PKN1 PAK1 PKN PRK1 PRKCL1 DFGLCKEGMGyGDRtstFCGtPEFLAPEVLTDTSYTRAVDW
Q16659 S189 EPSD MAPK6 ERK3 PRKM6 IGDFGLARIMDPHYSHKGHLsEGLVTKWYRSPRLLLSPNNY
Q16778 S37 Sugiyama H2BC21 H2BFQ HIST2H2BE KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q16778 S39 Sugiyama H2BC21 H2BFQ HIST2H2BE VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5SSJ5 S227 Sugiyama HP1BP3 LKRELNRGVIKQVKGKGAsGsFVVVQKSRKTPQKSRNRKNR
Q5SYE7 S1495 Sugiyama NHSL1 C6orf63 KIAA1357 KNRRAQEEWAKNEGLMPRsLsFsGPRYGRSRTPPSAASSRY
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6DN03 S37 Sugiyama H2BC20P HIST2H2BC KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DN03 S39 Sugiyama H2BC20P HIST2H2BC VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6 S37 Sugiyama H2BC19P HIST2H2BD KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DRA6 S39 Sugiyama H2BC19P HIST2H2BD VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q70Z35 S1107 EPSD PREX2 DEPDC2 FNVAGDEQEDSGHDTISNRDsYSDCNSNRNSIASFTSICSS
Q71UM5 S78 Sugiyama RPS27L GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86V81 S145 Sugiyama ALYREF ALY BEF THOC4 LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IYU2 S385 EPSD HACE1 KIAA1320 HSLDEWLVLIATELMKNKRDstEITSILLKQKGQDQDAASI
Q8IZ21 S590 Sugiyama PHACTR4 PRO2963 SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8N201 S495 Sugiyama INTS1 KIAA1440 UNQ1821/PRO3434 KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N257 S37 Sugiyama H2BC26 H2BU1 HIST3H2BB KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss
Q8N257 S39 Sugiyama H2BC26 H2BU1 HIST3H2BB VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8N8S7 S125 Sugiyama ENAH MENA MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8TD47 T247 Sugiyama RPS4Y2 RPS4Y2P VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8TEW0 S837 Sugiyama PARD3 PAR3 PAR3A AFQREGFGRQsMsEKRtKQFsDAsQLDFVKTRKsKsMDLGI
Q92890 S299 Sugiyama UFD1 UFD1L KKVEEDEAGGRFVAFsGEGQsLRKKGRKP____________
Q92934 S118 EPSD BAD BBC6 BCL2L8 RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934 S134 EPSD BAD BBC6 BCL2L8 LRRMsDEFVDsFKKGLPRPKsAGtATQMRQSSSWTRVFQsW
Q92934 S74 EPSD BAD BBC6 BCL2L8 QPTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFR
Q92934 S75 EPSD BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934 S99 EPSD BAD BBC6 BCL2L8 GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q92974 S886 SIGNOR|EPSD ARHGEF2 KIAA0651 LFP40 TEPLPAEAPWARRPVDPRRRsLPAGDALyLsFNPPQPSRGT
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96FS4 S55 Sugiyama SIPA1 SPA1 PLTPHTFEPRPVRGPLLRsGsDAGEARPPtPAsPRARAHsH
Q96T58 S3486 EPSD SPEN KIAA0929 MINT SHARP stPPGLVLPHTEFQPAPKQDssPHLTSQRPVDMVQLLKKYP
Q96T58 T3568 EPSD SPEN KIAA0929 MINT SHARP RIAQRMRLEATQLEGVARRMtVETDYCLLLALPCGRDQEDV
Q99426 S128 EPSD TBCB CG22 CKAP1 tIsQEAyDQRQDtVRSFLKRsKLGRyNEEERAQQEAEAAQR
Q99426 S65 EPSD TBCB CG22 CKAP1 VGSPASCMELELYGVDDKFYsKLDQEDALLGsYPVDDGCRI
Q99661 S111 EPSD KIF2C KNSL6 QKRRsVNSKIPAPKEsLRsRsTRMstVSELRITAQENDMEV
Q99661 S192 EPSD KIF2C KNSL6 QVHsIRGsssANPVNsVRRKsCLVKEVEKMKNKREEKKAQN
Q99848 S269 Sugiyama EBNA1BP2 EBP2 GFGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGS
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H788 S316 Sugiyama SH2D4A PPP1R38 SH2A NSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRAG
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9UGV2 T332 Sugiyama NDRG3 GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UHF1 S43 Sugiyama EGFL7 MEGF7 UNQ187/PRO1449 AYRPGRRVCAVRAHGDPVSEsFVQRVyQPFLTTCDGHRACS
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKV0 S253 EPSD|PSP HDAC9 HDAC7 HDAC7B HDRP KIAA0744 MITR KVAERRssPLLRRKDGNVVTsFKKRMFEVTESSVSSSSPGS
Q9UKV8 S387 Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9ULL1 S611 Sugiyama PLEKHG1 KIAA1209 GQMESTETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTREL
Q9UNX3 S31 Sugiyama RPL26L1 RPL26P1 RsKNRKRHFNAPSHVRRKIMssPLSKELRQKYNVRSMPIRK
Q9UPQ0 S377 Sugiyama LIMCH1 KIAA1102 LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ80 T261 EPSD PA2G4 EBP1 GQRTTIYKRDPSKQYGLKMKtSRAFFsEVERRFDAMPFtLR
Q9UQL6 T292 EPSD|PSP HDAC5 KIAA0600 KVAERRssPLLRRKDGTVIStFKKRAVEITGAGPGASSVCN
Q9Y2X7 S508 EPSD GIT1 AEHtPMAPGGstHRRDRQAFsMyEPGsALKPFGGPPGDELT
Q9Y2X7 S700 EPSD GIT1 LAVTEMASLFPKRPALEPVRsSLRLLNASAYRLQSECRKTV
Q9Y3B8 S203 Sugiyama REXO2 SFN SMFN CGI-114 EYEFAPKKAAsHRALDDIsEsIKELQFyRNNIFKKKIDEKK
Q9Y3C1 S16 Sugiyama NOP16 CGI-117 HSPC111 _____MPKAKGKTRRQKFGYsVNRKRLNRNARRKAAPRIEC
Q9Y5B9 S650 Sugiyama SUPT16H FACT140 FACTP140 KRYKTREAEEKEKEGIVKQDsLVINLNRsNPKLKDLYIRPN
Q9Y6X9 S739 EPSD MORC2 KIAA0852 ZCWCC1 VVKKtEsPIKLsPAtPsRKRsVAVsDEEEVEEEAERRKERC
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 3.419487e-14 13.466 1 0
Axon guidance R-HSA-422475 4.590506e-09 8.338 0 0
Cell Cycle R-HSA-1640170 2.099348e-08 7.678 0 0
Nervous system development R-HSA-9675108 6.186821e-08 7.209 0 0
Cellular Senescence R-HSA-2559583 9.050667e-08 7.043 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.934739e-07 6.532 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.934739e-07 6.532 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.217063e-07 6.375 0 0
Apoptotic execution phase R-HSA-75153 7.127429e-07 6.147 0 0
Cell Cycle Checkpoints R-HSA-69620 8.741008e-07 6.058 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.358450e-06 5.867 0 0
NRAGE signals death through JNK R-HSA-193648 1.487390e-06 5.828 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.025173e-06 5.694 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.967450e-06 5.706 0 0
Cell Cycle, Mitotic R-HSA-69278 4.963656e-06 5.304 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.185623e-06 5.285 0 0
Mitotic Prometaphase R-HSA-68877 1.133135e-05 4.946 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.324520e-05 4.878 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.329158e-05 4.876 0 0
G alpha (12/13) signalling events R-HSA-416482 1.582613e-05 4.801 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.016786e-05 4.520 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.722427e-05 4.429 0 0
Death Receptor Signaling R-HSA-73887 4.354724e-05 4.361 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.955517e-05 4.305 0 0
M Phase R-HSA-68886 5.442131e-05 4.264 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.356966e-05 4.271 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.815497e-05 4.107 0 0
Chromatin modifying enzymes R-HSA-3247509 7.599061e-05 4.119 0 0
Metalloprotease DUBs R-HSA-5689901 9.675972e-05 4.014 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.099401e-04 3.959 0 0
Chromatin organization R-HSA-4839726 1.185620e-04 3.926 0 0
Signaling by Hippo R-HSA-2028269 1.199154e-04 3.921 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.745934e-04 3.758 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.129864e-04 3.672 0 0
Separation of Sister Chromatids R-HSA-2467813 2.899217e-04 3.538 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.174096e-04 3.498 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.274759e-04 3.485 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.675270e-04 3.435 0 0
Semaphorin interactions R-HSA-373755 4.046425e-04 3.393 0 0
MAPK family signaling cascades R-HSA-5683057 4.409253e-04 3.356 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.924955e-04 3.308 0 0
L1CAM interactions R-HSA-373760 4.955929e-04 3.305 0 0
Meiosis R-HSA-1500620 7.057070e-04 3.151 0 0
Apoptosis R-HSA-109581 7.498039e-04 3.125 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.331178e-04 3.135 0 0
Meiotic synapsis R-HSA-1221632 8.057402e-04 3.094 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.854196e-04 3.105 0 0
Programmed Cell Death R-HSA-5357801 9.114319e-04 3.040 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.588146e-04 3.018 0 0
HATs acetylate histones R-HSA-3214847 9.826636e-04 3.008 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.064826e-03 2.973 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.224676e-03 2.912 0 0
Diseases of programmed cell death R-HSA-9645723 1.284078e-03 2.891 0 0
Recycling pathway of L1 R-HSA-437239 1.456031e-03 2.837 0 0
Mitotic Anaphase R-HSA-68882 1.501306e-03 2.824 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.563834e-03 2.806 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.992383e-03 2.701 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.226650e-03 2.652 0 0
CREB phosphorylation R-HSA-199920 2.226650e-03 2.652 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.082426e-03 2.681 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.082426e-03 2.681 0 0
DNA methylation R-HSA-5334118 2.197393e-03 2.658 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.067655e-03 2.685 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.919474e-03 2.717 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.764734e-03 2.753 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.228522e-03 2.652 0 0
FOXO-mediated transcription R-HSA-9614085 1.924008e-03 2.716 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.737754e-03 2.760 0 0
Netrin-1 signaling R-HSA-373752 1.960575e-03 2.708 0 0
Post NMDA receptor activation events R-HSA-438064 2.243722e-03 2.649 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.637993e-03 2.786 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.800240e-03 2.745 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.333286e-03 2.632 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.433023e-03 2.614 0 0
EPH-Ephrin signaling R-HSA-2682334 2.548420e-03 2.594 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.655778e-03 2.576 0 0
Signaling by Interleukins R-HSA-449147 2.852301e-03 2.545 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.926598e-03 2.534 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.969876e-03 2.527 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.099791e-03 2.509 0 0
Regulation of TP53 Activity R-HSA-5633007 3.134408e-03 2.504 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.715195e-03 2.430 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.755520e-03 2.425 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.890654e-03 2.410 0 0
Oncogene Induced Senescence R-HSA-2559585 3.952900e-03 2.403 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.089627e-03 2.388 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.501824e-03 2.347 0 0
RMTs methylate histone arginines R-HSA-3214858 4.621079e-03 2.335 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.723976e-03 2.326 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.796437e-03 2.319 0 0
Signaling by ROBO receptors R-HSA-376176 4.850856e-03 2.314 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.107265e-03 2.292 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.164234e-03 2.287 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.353698e-03 2.271 0 0
Deubiquitination R-HSA-5688426 5.427159e-03 2.265 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.500952e-03 2.260 0 0
Nucleosome assembly R-HSA-774815 5.500952e-03 2.260 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.963445e-03 2.225 0 0
Reproduction R-HSA-1474165 5.682164e-03 2.245 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.951850e-03 2.225 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.963445e-03 2.225 0 0
HDMs demethylate histones R-HSA-3214842 6.405975e-03 2.193 0 0
Sema4D in semaphorin signaling R-HSA-400685 6.405975e-03 2.193 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.643366e-03 2.178 0 0
Signaling by MAPK mutants R-HSA-9652817 6.643366e-03 2.178 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.882392e-03 2.162 0 0
Activation of RAC1 R-HSA-428540 6.882392e-03 2.162 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.512020e-03 2.186 0 0
Meiotic recombination R-HSA-912446 6.701211e-03 2.174 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.177070e-03 2.144 0 0
Cell-extracellular matrix interactions R-HSA-446353 7.243638e-03 2.140 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.776441e-03 2.109 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.701154e-03 2.060 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.732834e-03 2.059 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 8.732834e-03 2.059 0 0
Rap1 signalling R-HSA-392517 9.293179e-03 2.032 0 0
The NLRP3 inflammasome R-HSA-844456 9.293179e-03 2.032 0 0
Defective pyroptosis R-HSA-9710421 8.764681e-03 2.057 0 0
Signaling by VEGF R-HSA-194138 9.132792e-03 2.039 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 9.575638e-03 2.019 0 0
Packaging Of Telomere Ends R-HSA-171306 9.888069e-03 2.005 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.000470e-02 2.000 0 0
Ub-specific processing proteases R-HSA-5689880 1.046840e-02 1.980 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.030431e-02 1.987 0 0
Muscle contraction R-HSA-397014 1.031136e-02 1.987 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.888069e-03 2.005 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.888069e-03 2.005 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 9.896262e-03 2.005 0 0
Signaling by ALK in cancer R-HSA-9700206 9.896262e-03 2.005 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.077244e-02 1.968 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.087861e-02 1.963 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.181143e-02 1.928 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.181143e-02 1.928 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.187466e-02 1.925 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.187466e-02 1.925 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.187466e-02 1.925 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.253248e-02 1.902 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.296731e-02 1.887 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.352359e-02 1.869 0 0
Generic Transcription Pathway R-HSA-212436 1.347767e-02 1.870 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.314181e-02 1.881 0 0
Interleukin-12 signaling R-HSA-9020591 1.278611e-02 1.893 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.387337e-02 1.858 0 0
Ion homeostasis R-HSA-5578775 1.391884e-02 1.856 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.401668e-02 1.853 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.401668e-02 1.853 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.401668e-02 1.853 0 0
Signaling by RAS mutants R-HSA-6802949 1.401668e-02 1.853 0 0
Mitotic Prophase R-HSA-68875 1.455764e-02 1.837 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.512084e-02 1.820 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.512084e-02 1.820 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.512084e-02 1.820 0 0
DNA Double Strand Break Response R-HSA-5693606 1.523847e-02 1.817 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.610328e-02 1.793 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.610567e-02 1.793 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.545899e-02 1.811 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.509706e-02 1.821 0 0
Cellular responses to stress R-HSA-2262752 1.465202e-02 1.834 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.617731e-02 1.791 0 0
Cardiac conduction R-HSA-5576891 1.702845e-02 1.769 0 0
Interleukin-37 signaling R-HSA-9008059 1.763061e-02 1.754 0 0
Cell-Cell communication R-HSA-1500931 1.817973e-02 1.740 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.831365e-02 1.737 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.845592e-02 1.734 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.848589e-02 1.733 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.867096e-02 1.729 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.879967e-02 1.726 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.098395e-02 1.678 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.098395e-02 1.678 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.098395e-02 1.678 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.098395e-02 1.678 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.098395e-02 1.678 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.098395e-02 1.678 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.098395e-02 1.678 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.098395e-02 1.678 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.098395e-02 1.678 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.098395e-02 1.678 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.098395e-02 1.678 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.967744e-02 1.706 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.967744e-02 1.706 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.967744e-02 1.706 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.044099e-02 1.689 0 0
TRP channels R-HSA-3295583 2.003971e-02 1.698 0 0
RNA Polymerase II Transcription R-HSA-73857 2.097067e-02 1.678 0 0
DNA Repair R-HSA-73894 1.963560e-02 1.707 0 0
NrCAM interactions R-HSA-447038 1.967744e-02 1.706 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.175246e-02 1.662 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.306759e-02 1.637 0 0
Type I hemidesmosome assembly R-HSA-446107 2.306759e-02 1.637 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.333975e-02 1.632 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.333975e-02 1.632 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.518127e-02 1.599 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.517047e-02 1.599 1 1
HDACs deacetylate histones R-HSA-3214815 2.388667e-02 1.622 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.364980e-02 1.626 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.306759e-02 1.637 0 0
Kinesins R-HSA-983189 2.321474e-02 1.634 0 0
Cellular responses to stimuli R-HSA-8953897 2.452043e-02 1.610 0 0
Cell junction organization R-HSA-446728 2.292950e-02 1.640 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.321474e-02 1.634 0 0
Chromosome Maintenance R-HSA-73886 2.573218e-02 1.590 0 0
Potassium Channels R-HSA-1296071 2.597923e-02 1.585 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.701549e-02 1.568 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.747655e-02 1.561 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.748129e-02 1.561 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.898364e-02 1.538 0 0
MAP2K and MAPK activation R-HSA-5674135 2.898364e-02 1.538 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.898364e-02 1.538 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.924638e-02 1.534 0 0
Cleavage of the damaged purine R-HSA-110331 2.924638e-02 1.534 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.004551e-02 1.522 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.004551e-02 1.522 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.004551e-02 1.522 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.004551e-02 1.522 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.024594e-02 1.519 0 0
Stimuli-sensing channels R-HSA-2672351 3.041588e-02 1.517 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.055901e-02 1.515 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.055901e-02 1.515 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.055901e-02 1.515 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.055901e-02 1.515 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.055901e-02 1.515 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.055901e-02 1.515 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.451684e-02 1.462 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.376521e-02 1.472 0 0
Homology Directed Repair R-HSA-5693538 3.200510e-02 1.495 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.144449e-02 1.502 0 0
Sensory processing of sound R-HSA-9659379 3.177326e-02 1.498 0 0
Neurodegenerative Diseases R-HSA-8863678 3.296624e-02 1.482 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.296624e-02 1.482 0 0
Depurination R-HSA-73927 3.376521e-02 1.472 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.508275e-02 1.455 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.691550e-02 1.433 0 0
Developmental Biology R-HSA-1266738 3.897256e-02 1.409 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.910023e-02 1.408 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.910023e-02 1.408 0 0
Long-term potentiation R-HSA-9620244 3.917077e-02 1.407 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.919007e-02 1.407 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.938843e-02 1.405 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.938843e-02 1.405 0 0
Neuronal System R-HSA-112316 3.965954e-02 1.402 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.146702e-02 1.382 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.229551e-02 1.374 0 0
Membrane Trafficking R-HSA-199991 4.289701e-02 1.368 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.359743e-02 1.361 0 0
Interleukin-12 family signaling R-HSA-447115 4.387182e-02 1.358 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.503600e-02 1.346 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.506548e-02 1.346 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.532817e-02 1.344 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.535161e-02 1.343 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.612315e-02 1.336 0 0
Rab regulation of trafficking R-HSA-9007101 4.618067e-02 1.336 0 0
Gene expression (Transcription) R-HSA-74160 4.625965e-02 1.335 0 0
Signaling by APC mutants R-HSA-4839744 5.468201e-02 1.262 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.468201e-02 1.262 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.468201e-02 1.262 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.468201e-02 1.262 0 0
cGMP effects R-HSA-418457 4.902157e-02 1.310 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.311250e-02 1.275 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.189894e-02 1.285 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.827688e-02 1.316 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.827688e-02 1.316 0 0
ESR-mediated signaling R-HSA-8939211 4.754468e-02 1.323 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.072331e-02 1.295 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.434469e-02 1.265 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.827688e-02 1.316 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.904593e-02 1.309 0 0
DAG and IP3 signaling R-HSA-1489509 4.847067e-02 1.315 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.241756e-02 1.281 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.241756e-02 1.281 0 0
FLT3 Signaling R-HSA-9607240 5.026255e-02 1.299 0 0
Signaling by NOTCH R-HSA-157118 5.540715e-02 1.256 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.668157e-02 1.247 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.750717e-02 1.240 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.750717e-02 1.240 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.750717e-02 1.240 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.795243e-02 1.237 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.795243e-02 1.237 0 0
mRNA 3'-end processing R-HSA-72187 5.810293e-02 1.236 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.888161e-02 1.230 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 5.888161e-02 1.230 0 0
Ca2+ activated K+ channels R-HSA-1296052 5.888161e-02 1.230 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.888161e-02 1.230 0 0
Regulation of PTEN localization R-HSA-8948747 5.888161e-02 1.230 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.897933e-02 1.229 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.019173e-02 1.220 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 6.035934e-02 1.219 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.035934e-02 1.219 0 0
Protein methylation R-HSA-8876725 6.035934e-02 1.219 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.035934e-02 1.219 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.035934e-02 1.219 0 0
Integrin signaling R-HSA-354192 6.089640e-02 1.215 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.125268e-02 1.213 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.074454e-02 1.150 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 7.074454e-02 1.150 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 7.074454e-02 1.150 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 7.074454e-02 1.150 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 7.074454e-02 1.150 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 7.074454e-02 1.150 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 7.074454e-02 1.150 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 7.074454e-02 1.150 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 7.074454e-02 1.150 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.894975e-02 1.161 0 0
Phase 4 - resting membrane potential R-HSA-5576886 7.312780e-02 1.136 0 0
Centrosome maturation R-HSA-380287 6.224648e-02 1.206 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.145162e-02 1.211 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.271996e-02 1.203 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.393188e-02 1.194 0 0
Platelet calcium homeostasis R-HSA-418360 7.171286e-02 1.144 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.192009e-02 1.143 0 0
MTOR signalling R-HSA-165159 6.389332e-02 1.195 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.029801e-02 1.153 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.148330e-02 1.211 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.357882e-02 1.133 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.357882e-02 1.133 0 0
Signaling by AXIN mutants R-HSA-4839735 6.894975e-02 1.161 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.894975e-02 1.161 0 0
Inflammasomes R-HSA-622312 6.237571e-02 1.205 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.148330e-02 1.211 0 0
Formation of definitive endoderm R-HSA-9823730 7.417088e-02 1.130 0 0
RAB geranylgeranylation R-HSA-8873719 7.430724e-02 1.129 0 0
Signaling by ALK R-HSA-201556 7.509520e-02 1.124 0 0
Peptide chain elongation R-HSA-156902 7.659155e-02 1.116 0 0
G2/M Transition R-HSA-69275 7.668436e-02 1.115 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.731800e-02 1.112 0 0
RSK activation R-HSA-444257 7.731800e-02 1.112 0 0
Formation of annular gap junctions R-HSA-196025 7.731800e-02 1.112 0 0
Adrenoceptors R-HSA-390696 7.731800e-02 1.112 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.731800e-02 1.112 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.731800e-02 1.112 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.866345e-02 1.104 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.866345e-02 1.104 0 0
Signaling by WNT R-HSA-195721 8.060178e-02 1.094 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.187120e-02 1.087 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.187120e-02 1.087 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 8.239825e-02 1.084 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 8.239825e-02 1.084 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.410246e-02 1.075 0 0
Formation of the nephric duct R-HSA-9830364 8.472815e-02 1.072 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.507444e-02 1.070 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.507444e-02 1.070 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.507444e-02 1.070 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.553509e-02 1.068 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.612255e-02 1.065 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.664428e-02 1.062 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.664428e-02 1.062 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 8.853841e-02 1.053 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.110820e-01 0.954 0 0
Lipophagy R-HSA-9613354 9.828197e-02 1.008 0 0
Gap junction degradation R-HSA-190873 9.828197e-02 1.008 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 9.828197e-02 1.008 0 0
ALK mutants bind TKIs R-HSA-9700645 9.828197e-02 1.008 0 0
Formation of axial mesoderm R-HSA-9796292 1.029966e-01 0.987 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.029064e-01 0.988 0 0
Trafficking of AMPA receptors R-HSA-399719 9.285296e-02 1.032 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.101423e-01 0.958 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.374844e-02 1.028 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.902127e-02 1.004 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.574257e-02 1.019 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.092295e-01 0.962 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.675725e-02 1.014 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.675725e-02 1.014 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.024435e-01 0.990 0 0
mRNA Splicing R-HSA-72172 1.060300e-01 0.975 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.101865e-01 0.958 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.723040e-02 1.012 0 0
GP1b-IX-V activation signalling R-HSA-430116 9.828197e-02 1.008 0 0
Telomere Maintenance R-HSA-157579 1.101865e-01 0.958 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.914438e-02 1.004 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.107661e-01 0.956 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 9.828197e-02 1.008 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.046537e-01 0.980 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.696245e-02 1.013 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.666082e-02 1.015 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.029966e-01 0.987 0 0
Neurexins and neuroligins R-HSA-6794361 1.011743e-01 0.995 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.666082e-02 1.015 0 0
Calmodulin induced events R-HSA-111933 9.914438e-02 1.004 0 0
CaM pathway R-HSA-111997 9.914438e-02 1.004 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.029966e-01 0.987 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 9.302944e-02 1.031 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.020037e-01 0.991 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.915192e-02 1.050 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.005104e-01 0.998 0 0
PI Metabolism R-HSA-1483255 1.032093e-01 0.986 0 0
Signaling by NTRKs R-HSA-166520 9.429532e-02 1.026 0 0
Specification of primordial germ cells R-HSA-9827857 1.029064e-01 0.988 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.147040e-01 0.940 0 0
Regulation of TP53 Expression R-HSA-6804754 1.147040e-01 0.940 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.147040e-01 0.940 0 0
Diseases of cellular response to stress R-HSA-9675132 1.147040e-01 0.940 0 0
Regulation of cortical dendrite branching R-HSA-8985801 1.147040e-01 0.940 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.147040e-01 0.940 0 0
C6 deamination of adenosine R-HSA-75102 1.147040e-01 0.940 0 0
Potassium transport channels R-HSA-1296067 1.147040e-01 0.940 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.149508e-01 0.939 0 0
Depyrimidination R-HSA-73928 1.149508e-01 0.939 0 0
mTORC1-mediated signalling R-HSA-166208 1.153622e-01 0.938 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 1.153622e-01 0.938 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.153622e-01 0.938 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.159410e-01 0.936 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.172625e-01 0.931 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.172625e-01 0.931 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.172625e-01 0.931 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.172625e-01 0.931 0 0
Selective autophagy R-HSA-9663891 1.176426e-01 0.929 0 0
Co-stimulation by CD28 R-HSA-389356 1.183317e-01 0.927 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.183317e-01 0.927 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.198413e-01 0.921 0 0
Apoptotic factor-mediated response R-HSA-111471 1.198413e-01 0.921 0 0
Ephrin signaling R-HSA-3928664 1.198413e-01 0.921 0 0
Polo-like kinase mediated events R-HSA-156711 1.198413e-01 0.921 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.198413e-01 0.921 0 0
Translation initiation complex formation R-HSA-72649 1.208747e-01 0.918 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.215841e-01 0.915 0 0
Regulation of CDH11 function R-HSA-9762292 1.215841e-01 0.915 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.215841e-01 0.915 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.215841e-01 0.915 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.226257e-01 0.911 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.227531e-01 0.911 0 0
TBC/RABGAPs R-HSA-8854214 1.264946e-01 0.898 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.345552e-01 0.871 0 0
KIT mutants bind TKIs R-HSA-9669921 1.345552e-01 0.871 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.345552e-01 0.871 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.345552e-01 0.871 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.345552e-01 0.871 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.345552e-01 0.871 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.345552e-01 0.871 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.345552e-01 0.871 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.345552e-01 0.871 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.345552e-01 0.871 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.345552e-01 0.871 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.345552e-01 0.871 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.345552e-01 0.871 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.345552e-01 0.871 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.345552e-01 0.871 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.636603e-01 0.786 0 0
Axonal growth stimulation R-HSA-209563 1.636603e-01 0.786 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.636603e-01 0.786 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.636603e-01 0.786 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.429726e-01 0.845 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.469914e-01 0.833 0 0
DCC mediated attractive signaling R-HSA-418885 1.438450e-01 0.842 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.380599e-01 0.860 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.665164e-01 0.779 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.312903e-01 0.882 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.574825e-01 0.803 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.574825e-01 0.803 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.574825e-01 0.803 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.574825e-01 0.803 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.574825e-01 0.803 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.392471e-01 0.856 0 0
Striated Muscle Contraction R-HSA-390522 1.306620e-01 0.884 0 0
RAF activation R-HSA-5673000 1.448290e-01 0.839 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.448290e-01 0.839 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.426155e-01 0.846 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.329601e-01 0.876 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.658461e-01 0.780 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.733825e-01 0.761 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.324333e-01 0.878 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.306620e-01 0.884 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.514074e-01 0.820 0 0
DARPP-32 events R-HSA-180024 1.392471e-01 0.856 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.663189e-01 0.779 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.542282e-01 0.812 0 0
G2/M Checkpoints R-HSA-69481 1.358758e-01 0.867 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.380599e-01 0.860 0 0
TNF signaling R-HSA-75893 1.426155e-01 0.846 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.665164e-01 0.779 0 0
Activation of BH3-only proteins R-HSA-114452 1.551062e-01 0.809 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.636603e-01 0.786 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.682552e-01 0.774 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.438450e-01 0.842 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.661740e-01 0.779 0 0
Cell-cell junction organization R-HSA-421270 1.535184e-01 0.814 0 0
Selenocysteine synthesis R-HSA-2408557 1.416250e-01 0.849 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.392471e-01 0.856 0 0
Regulated Necrosis R-HSA-5218859 1.441723e-01 0.841 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.542282e-01 0.812 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.663065e-01 0.779 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.353087e-01 0.869 0 0
Base Excision Repair R-HSA-73884 1.343869e-01 0.872 0 0
Gene Silencing by RNA R-HSA-211000 1.489531e-01 0.827 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.647417e-01 0.783 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.742408e-01 0.759 0 0
RET signaling R-HSA-8853659 1.753436e-01 0.756 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.774544e-01 0.751 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.774544e-01 0.751 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.776910e-01 0.750 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.776910e-01 0.750 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.780167e-01 0.750 0 0
ERK/MAPK targets R-HSA-198753 1.780167e-01 0.750 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.510121e-01 0.600 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.510121e-01 0.600 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.510121e-01 0.600 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 2.510121e-01 0.600 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.510121e-01 0.600 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.510121e-01 0.600 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.510121e-01 0.600 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.510121e-01 0.600 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.510121e-01 0.600 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.510121e-01 0.600 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.510121e-01 0.600 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.510121e-01 0.600 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.510121e-01 0.600 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.510121e-01 0.600 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.510121e-01 0.600 0 0
NADE modulates death signalling R-HSA-205025 2.154742e-01 0.667 0 0
HCN channels R-HSA-1296061 2.154742e-01 0.667 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.154742e-01 0.667 0 0
ATP sensitive Potassium channels R-HSA-1296025 2.154742e-01 0.667 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.154742e-01 0.667 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.154742e-01 0.667 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.154742e-01 0.667 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.154742e-01 0.667 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.154742e-01 0.667 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.154742e-01 0.667 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.518040e-01 0.454 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.518040e-01 0.454 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.518040e-01 0.454 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.518040e-01 0.454 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.518040e-01 0.454 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.518040e-01 0.454 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.518040e-01 0.454 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.518040e-01 0.454 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.518040e-01 0.454 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.518040e-01 0.454 0 0
Intestinal infectious diseases R-HSA-8942233 3.518040e-01 0.454 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.518040e-01 0.454 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.518040e-01 0.454 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.518040e-01 0.454 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.518040e-01 0.454 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.518040e-01 0.454 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.518040e-01 0.454 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 3.518040e-01 0.454 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.518040e-01 0.454 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.518040e-01 0.454 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.518040e-01 0.454 0 0
MPS IIID - Sanfilippo syndrome D R-HSA-2206305 3.518040e-01 0.454 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.518040e-01 0.454 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.518040e-01 0.454 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.518040e-01 0.454 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.684912e-01 0.571 0 0
IRS activation R-HSA-74713 2.684912e-01 0.571 0 0
G2 Phase R-HSA-68911 2.684912e-01 0.571 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.684912e-01 0.571 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 2.684912e-01 0.571 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.684912e-01 0.571 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 2.684912e-01 0.571 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 2.139160e-01 0.670 0 0
FGFR1b ligand binding and activation R-HSA-190370 2.139160e-01 0.670 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.517745e-01 0.599 0 0
ARMS-mediated activation R-HSA-170984 2.517745e-01 0.599 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 2.517745e-01 0.599 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.517745e-01 0.599 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.214500e-01 0.493 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.214500e-01 0.493 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.214500e-01 0.493 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.214500e-01 0.493 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.214500e-01 0.493 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.214500e-01 0.493 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.214500e-01 0.493 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.390372e-01 0.357 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 4.390372e-01 0.357 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.390372e-01 0.357 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.390372e-01 0.357 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.390372e-01 0.357 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.390372e-01 0.357 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.390372e-01 0.357 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.390372e-01 0.357 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.331321e-01 0.632 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 2.904909e-01 0.537 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.904909e-01 0.537 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.904909e-01 0.537 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.155862e-01 0.666 0 0
Regulation of KIT signaling R-HSA-1433559 2.641957e-01 0.578 0 0
CRMPs in Sema3A signaling R-HSA-399956 2.641957e-01 0.578 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.734068e-01 0.428 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.734068e-01 0.428 0 0
STAT5 Activation R-HSA-9645135 3.734068e-01 0.428 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 3.734068e-01 0.428 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.734068e-01 0.428 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.416450e-01 0.617 0 0
Notch-HLH transcription pathway R-HSA-350054 2.220006e-01 0.654 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.295788e-01 0.482 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.295788e-01 0.482 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.046671e-01 0.689 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.959602e-01 0.529 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.959602e-01 0.529 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.959602e-01 0.529 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.684852e-01 0.571 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.452222e-01 0.610 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.073674e-01 0.683 0 0
Voltage gated Potassium channels R-HSA-1296072 1.916178e-01 0.718 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.261646e-01 0.646 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.261646e-01 0.646 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.691042e-01 0.570 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.691042e-01 0.570 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.281574e-01 0.484 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.281574e-01 0.484 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.686095e-01 0.433 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.686095e-01 0.433 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.686095e-01 0.433 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 4.236726e-01 0.373 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.236726e-01 0.373 0 0
Netrin mediated repulsion signals R-HSA-418886 4.236726e-01 0.373 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 4.236726e-01 0.373 0 0
SOS-mediated signalling R-HSA-112412 4.236726e-01 0.373 0 0
Disinhibition of SNARE formation R-HSA-114516 4.236726e-01 0.373 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.236726e-01 0.373 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.145351e-01 0.289 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 5.145351e-01 0.289 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.145351e-01 0.289 0 0
Invadopodia formation R-HSA-8941237 5.145351e-01 0.289 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.145351e-01 0.289 0 0
MET activates PTPN11 R-HSA-8865999 5.145351e-01 0.289 0 0
Classical Kir channels R-HSA-1296053 5.145351e-01 0.289 0 0
Defective ABCA1 causes TGD R-HSA-5682113 5.145351e-01 0.289 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.145351e-01 0.289 0 0
Tight junction interactions R-HSA-420029 2.935244e-01 0.532 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.935244e-01 0.532 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.238075e-01 0.490 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.605361e-01 0.443 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.605361e-01 0.443 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.605361e-01 0.443 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.605361e-01 0.443 0 0
EGFR downregulation R-HSA-182971 2.899579e-01 0.538 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.899579e-01 0.538 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.072126e-01 0.390 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.072126e-01 0.390 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.072126e-01 0.390 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.072126e-01 0.390 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.072126e-01 0.390 0 0
Polymerase switching R-HSA-69091 4.072126e-01 0.390 0 0
Leading Strand Synthesis R-HSA-69109 4.072126e-01 0.390 0 0
HSF1-dependent transactivation R-HSA-3371571 2.392062e-01 0.621 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.519493e-01 0.454 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.124992e-01 0.505 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.434930e-01 0.464 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.434930e-01 0.464 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.434930e-01 0.464 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.928651e-01 0.406 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.928651e-01 0.406 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.928651e-01 0.406 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.717617e-01 0.326 0 0
Activation of RAS in B cells R-HSA-1169092 4.717617e-01 0.326 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.717617e-01 0.326 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.717617e-01 0.326 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.922961e-01 0.716 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.353468e-01 0.475 0 0
FGFR2 alternative splicing R-HSA-6803529 3.801965e-01 0.420 0 0
Cellular response to heat stress R-HSA-3371556 1.799808e-01 0.745 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.688045e-01 0.433 0 0
HIV elongation arrest and recovery R-HSA-167287 3.688045e-01 0.433 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.688045e-01 0.433 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.450751e-01 0.352 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.584109e-01 0.446 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.488224e-01 0.457 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.488224e-01 0.457 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.249352e-01 0.372 0 0
PKA activation in glucagon signalling R-HSA-164378 4.249352e-01 0.372 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.941830e-01 0.404 0 0
Late endosomal microautophagy R-HSA-9615710 3.941830e-01 0.404 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.941830e-01 0.404 0 0
HIV Transcription Elongation R-HSA-167169 3.702569e-01 0.431 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.702569e-01 0.431 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.702569e-01 0.431 0 0
Attenuation phase R-HSA-3371568 3.702569e-01 0.431 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.702569e-01 0.431 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.067777e-01 0.684 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.792764e-01 0.554 0 0
Viral mRNA Translation R-HSA-192823 2.975877e-01 0.526 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.591867e-01 0.445 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.691776e-01 0.433 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.195216e-01 0.377 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.364204e-01 0.360 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 4.364204e-01 0.360 0 0
Deadenylation of mRNA R-HSA-429947 4.364204e-01 0.360 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.565600e-01 0.341 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.819385e-01 0.317 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.819385e-01 0.317 0 0
WNT mediated activation of DVL R-HSA-201688 5.173497e-01 0.286 0 0
CASP8 activity is inhibited R-HSA-5218900 5.173497e-01 0.286 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 3.881785e-01 0.411 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.133501e-01 0.384 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.820818e-01 0.550 0 0
Downstream signal transduction R-HSA-186763 4.447200e-01 0.352 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.875762e-01 0.312 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.875762e-01 0.312 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.133240e-01 0.384 0 0
Translesion synthesis by REV1 R-HSA-110312 5.175946e-01 0.286 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.175946e-01 0.286 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.606316e-01 0.337 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.531946e-01 0.344 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.178436e-01 0.286 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.178436e-01 0.286 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.178436e-01 0.286 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.178436e-01 0.286 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.966801e-01 0.304 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.181804e-01 0.286 0 0
Metabolism of non-coding RNA R-HSA-194441 5.018895e-01 0.299 0 0
snRNP Assembly R-HSA-191859 5.018895e-01 0.299 0 0
Co-inhibition by PD-1 R-HSA-389948 3.604122e-01 0.443 0 0
Signaling by FGFR2 R-HSA-5654738 5.056507e-01 0.296 0 0
PKR-mediated signaling R-HSA-9833482 5.056507e-01 0.296 0 0
Hedgehog 'off' state R-HSA-5610787 4.380497e-01 0.358 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 4.564637e-01 0.341 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.912914e-01 0.536 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.001794e-01 0.699 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.793100e-01 0.319 0 0
Nucleotide Excision Repair R-HSA-5696398 5.236373e-01 0.281 0 0
IGF1R signaling cascade R-HSA-2428924 3.498797e-01 0.456 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.133501e-01 0.384 0 0
Signaling by EGFR R-HSA-177929 2.213843e-01 0.655 0 0
Specification of the neural plate border R-HSA-9834899 2.684852e-01 0.571 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.943302e-01 0.306 0 0
Signaling by FGFR3 R-HSA-5654741 4.986577e-01 0.302 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.249352e-01 0.372 0 0
Signaling by FGFR4 R-HSA-5654743 4.563098e-01 0.341 0 0
p75NTR signals via NF-kB R-HSA-193639 2.959602e-01 0.529 0 0
Signaling by SCF-KIT R-HSA-1433557 3.201105e-01 0.495 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.065206e-01 0.514 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.450751e-01 0.352 0 0
DNA Damage Bypass R-HSA-73893 2.079774e-01 0.682 0 0
Developmental Cell Lineages R-HSA-9734767 5.147635e-01 0.288 0 0
RUNX2 regulates bone development R-HSA-8941326 2.857944e-01 0.544 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.959304e-01 0.529 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 3.686095e-01 0.433 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.928651e-01 0.406 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.594076e-01 0.338 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.952691e-01 0.709 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.183607e-01 0.497 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.917884e-01 0.407 0 0
mRNA Editing R-HSA-75072 2.517745e-01 0.599 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.850054e-01 0.733 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.046671e-01 0.689 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.605361e-01 0.443 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.941830e-01 0.404 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.726846e-01 0.564 0 0
G1 Phase R-HSA-69236 3.398999e-01 0.469 0 0
Cyclin D associated events in G1 R-HSA-69231 3.398999e-01 0.469 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.993490e-01 0.700 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.688045e-01 0.433 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.173497e-01 0.286 0 0
TGFBR3 expression R-HSA-9839394 4.641316e-01 0.333 0 0
Signaling by ERBB2 R-HSA-1227986 1.918695e-01 0.717 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.833666e-01 0.737 0 0
Aggrephagy R-HSA-9646399 3.702569e-01 0.431 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.129992e-01 0.504 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.129992e-01 0.504 0 0
Signal attenuation R-HSA-74749 2.904909e-01 0.537 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.238075e-01 0.490 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.819385e-01 0.317 0 0
Inwardly rectifying K+ channels R-HSA-1296065 4.696848e-01 0.328 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.531946e-01 0.344 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.669445e-01 0.435 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.737915e-01 0.427 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.641957e-01 0.578 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.691042e-01 0.570 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.079774e-01 0.682 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.717617e-01 0.326 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.353468e-01 0.475 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.442429e-01 0.612 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.213487e-01 0.283 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.605361e-01 0.443 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.927746e-01 0.715 0 0
MHC class II antigen presentation R-HSA-2132295 1.982839e-01 0.703 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.154742e-01 0.667 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.214500e-01 0.493 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.214500e-01 0.493 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.214500e-01 0.493 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.734068e-01 0.428 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.959602e-01 0.529 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.236726e-01 0.373 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.717617e-01 0.326 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.819385e-01 0.317 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 5.173497e-01 0.286 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.641316e-01 0.333 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.641316e-01 0.333 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.175946e-01 0.286 0 0
Signalling to RAS R-HSA-167044 5.178436e-01 0.286 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.816042e-01 0.418 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.173497e-01 0.286 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.519493e-01 0.454 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.584109e-01 0.446 0 0
Mismatch Repair R-HSA-5358508 4.249352e-01 0.372 0 0
Generation of second messenger molecules R-HSA-202433 3.702569e-01 0.431 0 0
S Phase R-HSA-69242 4.450356e-01 0.352 0 0
Opioid Signalling R-HSA-111885 2.326978e-01 0.633 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.434930e-01 0.464 0 0
Dopamine receptors R-HSA-390651 2.154742e-01 0.667 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.139160e-01 0.670 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.517745e-01 0.599 0 0
Passive transport by Aquaporins R-HSA-432047 1.904855e-01 0.720 0 0
Sodium/Calcium exchangers R-HSA-425561 3.686095e-01 0.433 0 0
NF-kB is activated and signals survival R-HSA-209560 3.686095e-01 0.433 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.072126e-01 0.390 0 0
Regulation by c-FLIP R-HSA-3371378 4.717617e-01 0.326 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.353468e-01 0.475 0 0
PKA activation R-HSA-163615 4.249352e-01 0.372 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.083997e-01 0.389 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.957494e-01 0.403 0 0
Interleukin-2 signaling R-HSA-9020558 3.295788e-01 0.482 0 0
Cellular response to chemical stress R-HSA-9711123 2.193658e-01 0.659 0 0
G-protein mediated events R-HSA-112040 2.934252e-01 0.533 0 0
Autophagy R-HSA-9612973 2.447966e-01 0.611 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.914189e-01 0.309 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.917884e-01 0.407 0 0
Aquaporin-mediated transport R-HSA-445717 4.133240e-01 0.384 0 0
Signaling by Hedgehog R-HSA-5358351 4.775235e-01 0.321 0 0
Signalling to ERKs R-HSA-187687 2.654462e-01 0.576 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 2.461575e-01 0.609 0 0
Repression of WNT target genes R-HSA-4641265 4.072126e-01 0.390 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.574126e-01 0.447 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.957494e-01 0.403 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.013615e-01 0.396 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.590574e-01 0.587 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.326978e-01 0.633 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.591101e-01 0.445 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.737496e-01 0.563 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.687882e-01 0.571 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.048420e-01 0.393 0 0
Integration of energy metabolism R-HSA-163685 3.711329e-01 0.430 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.252244e-01 0.647 0 0
Signaling by WNT in cancer R-HSA-4791275 1.892192e-01 0.723 0 0
Transmission across Chemical Synapses R-HSA-112315 1.952691e-01 0.709 0 0
Calcineurin activates NFAT R-HSA-2025928 2.517745e-01 0.599 0 0
Cardiogenesis R-HSA-9733709 2.073674e-01 0.683 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 3.686095e-01 0.433 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.717617e-01 0.326 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.717617e-01 0.326 0 0
Dimerization of procaspase-8 R-HSA-69416 4.717617e-01 0.326 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.450751e-01 0.352 0 0
FGFR1c ligand binding and activation R-HSA-190373 4.450751e-01 0.352 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.598770e-01 0.444 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.952175e-01 0.403 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.952175e-01 0.403 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.952175e-01 0.403 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.952175e-01 0.403 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.641316e-01 0.333 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.088544e-01 0.510 0 0
Macroautophagy R-HSA-1632852 3.516821e-01 0.454 0 0
PLC beta mediated events R-HSA-112043 2.052919e-01 0.688 0 0
Interleukin-2 family signaling R-HSA-451927 2.439778e-01 0.613 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.605361e-01 0.443 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.195216e-01 0.377 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.673390e-01 0.435 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.760523e-01 0.559 0 0
Signaling by TGFB family members R-HSA-9006936 4.263271e-01 0.370 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.331321e-01 0.632 0 0
Pyroptosis R-HSA-5620971 2.250793e-01 0.648 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.333228e-01 0.632 0 0
Signaling by PTK6 R-HSA-8848021 2.333228e-01 0.632 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.916000e-01 0.407 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 2.590574e-01 0.587 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 2.590574e-01 0.587 0 0
Signaling by TGFBR3 R-HSA-9839373 3.799849e-01 0.420 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.244631e-01 0.489 0 0
Metabolism of RNA R-HSA-8953854 4.286352e-01 0.368 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.684912e-01 0.571 0 0
Signaling by LTK R-HSA-9842663 2.030509e-01 0.692 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 3.214500e-01 0.493 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.214500e-01 0.493 0 0
Formation of intermediate mesoderm R-HSA-9761174 2.904909e-01 0.537 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.959602e-01 0.529 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.281574e-01 0.484 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.281574e-01 0.484 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 3.928651e-01 0.406 0 0
Eukaryotic Translation Termination R-HSA-72764 2.029990e-01 0.693 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.275535e-01 0.485 0 0
Cilium Assembly R-HSA-5617833 3.280706e-01 0.484 0 0
p38MAPK events R-HSA-171007 5.175946e-01 0.286 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.943302e-01 0.306 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.953653e-01 0.305 0 0
Ca-dependent events R-HSA-111996 1.927746e-01 0.715 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.353468e-01 0.475 0 0
Adherens junctions interactions R-HSA-418990 1.882341e-01 0.725 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.684912e-01 0.571 0 0
Neurofascin interactions R-HSA-447043 3.734068e-01 0.428 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.734068e-01 0.428 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.073674e-01 0.683 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.941830e-01 0.404 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.048420e-01 0.393 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.185780e-01 0.285 0 0
Signaling by NOTCH1 R-HSA-1980143 2.402089e-01 0.619 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.280403e-01 0.369 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.594648e-01 0.338 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.139787e-01 0.670 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.594648e-01 0.338 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.989260e-01 0.302 0 0
G-protein beta:gamma signalling R-HSA-397795 3.353468e-01 0.475 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.204056e-01 0.284 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.989260e-01 0.302 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.172367e-01 0.499 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.737915e-01 0.427 0 0
Ion channel transport R-HSA-983712 2.043748e-01 0.690 0 0
Platelet homeostasis R-HSA-418346 2.673223e-01 0.573 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.172367e-01 0.499 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.172367e-01 0.499 0 0
Inhibition of PKR R-HSA-169131 2.510121e-01 0.600 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.518040e-01 0.454 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.518040e-01 0.454 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.684912e-01 0.571 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.517745e-01 0.599 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 3.214500e-01 0.493 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.390372e-01 0.357 0 0
Bicarbonate transporters R-HSA-425381 3.295788e-01 0.482 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.295788e-01 0.482 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.959304e-01 0.529 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.236726e-01 0.373 0 0
MET interacts with TNS proteins R-HSA-8875513 5.145351e-01 0.289 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.455465e-01 0.610 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.717617e-01 0.326 0 0
Co-stimulation by ICOS R-HSA-9927354 4.717617e-01 0.326 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.083997e-01 0.389 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.816042e-01 0.418 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.383370e-01 0.471 0 0
FLT3 signaling in disease R-HSA-9682385 4.280431e-01 0.369 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.990289e-01 0.524 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.914189e-01 0.309 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.178436e-01 0.286 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.966801e-01 0.304 0 0
Diseases of Immune System R-HSA-5260271 5.190124e-01 0.285 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.190124e-01 0.285 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.266086e-01 0.279 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.275535e-01 0.485 0 0
Signaling by ERBB4 R-HSA-1236394 4.067943e-01 0.391 0 0
Amine ligand-binding receptors R-HSA-375280 3.398999e-01 0.469 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.952175e-01 0.403 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.691042e-01 0.570 0 0
Amyloid fiber formation R-HSA-977225 3.104531e-01 0.508 0 0
UCH proteinases R-HSA-5689603 3.329369e-01 0.478 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.966222e-01 0.304 0 0
Interleukin-1 family signaling R-HSA-446652 4.920904e-01 0.308 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.966222e-01 0.304 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.236373e-01 0.281 0 0
PECAM1 interactions R-HSA-210990 3.295788e-01 0.482 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.678137e-01 0.572 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.684912e-01 0.571 0 0
LGI-ADAM interactions R-HSA-5682910 3.295788e-01 0.482 0 0
CHL1 interactions R-HSA-447041 4.236726e-01 0.373 0 0
Interleukin-1 processing R-HSA-448706 5.173497e-01 0.286 0 0
Protein hydroxylation R-HSA-9629569 4.875762e-01 0.312 0 0
Glycolysis R-HSA-70171 4.380497e-01 0.358 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.003717e-01 0.301 0 0
MAP kinase activation R-HSA-450294 5.386984e-01 0.269 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.380218e-01 0.269 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.214500e-01 0.493 0 0
DSCAM interactions R-HSA-376172 4.390372e-01 0.357 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.904909e-01 0.537 0 0
Platelet sensitization by LDL R-HSA-432142 2.416450e-01 0.617 0 0
Synthesis of PI R-HSA-1483226 3.295788e-01 0.482 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.073674e-01 0.683 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.145351e-01 0.289 0 0
OAS antiviral response R-HSA-8983711 4.072126e-01 0.390 0 0
Maturation of nucleoprotein R-HSA-9683610 4.450751e-01 0.352 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.072386e-01 0.390 0 0
Diseases of DNA repair R-HSA-9675135 3.799849e-01 0.420 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.531946e-01 0.344 0 0
Signal regulatory protein family interactions R-HSA-391160 2.641957e-01 0.578 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 4.195216e-01 0.377 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.238075e-01 0.490 0 0
Insulin processing R-HSA-264876 5.181804e-01 0.286 0 0
Histamine receptors R-HSA-390650 5.145351e-01 0.289 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.519493e-01 0.454 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.740321e-01 0.324 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.973642e-01 0.705 0 0
Formation of the anterior neural plate R-HSA-9823739 5.175946e-01 0.286 0 0
Co-inhibition by BTLA R-HSA-9927353 2.684912e-01 0.571 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.214500e-01 0.493 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.390372e-01 0.357 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 4.236726e-01 0.373 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.145351e-01 0.289 0 0
Interleukin-18 signaling R-HSA-9012546 4.717617e-01 0.326 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.173497e-01 0.286 0 0
Other interleukin signaling R-HSA-449836 2.684852e-01 0.571 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.641957e-01 0.578 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.178436e-01 0.286 0 0
Influenza Infection R-HSA-168255 2.861380e-01 0.543 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.003717e-01 0.301 0 0
Signaling by Leptin R-HSA-2586552 2.904909e-01 0.537 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.684852e-01 0.571 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.959602e-01 0.529 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.236726e-01 0.373 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.173497e-01 0.286 0 0
Interleukin-7 signaling R-HSA-1266695 4.641316e-01 0.333 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.926964e-01 0.715 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.249352e-01 0.372 0 0
Growth hormone receptor signaling R-HSA-982772 4.083997e-01 0.389 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.816042e-01 0.418 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.525675e-01 0.344 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.423582e-01 0.266 0 0
Dual Incision in GG-NER R-HSA-5696400 5.423582e-01 0.266 0 0
Mitophagy R-HSA-5205647 5.423582e-01 0.266 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.443267e-01 0.264 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.443267e-01 0.264 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.443267e-01 0.264 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.443267e-01 0.264 0 0
Telomere Extension By Telomerase R-HSA-171319 5.443267e-01 0.264 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.443267e-01 0.264 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.443267e-01 0.264 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.472438e-01 0.262 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.472438e-01 0.262 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.472438e-01 0.262 0 0
Adaptive Immune System R-HSA-1280218 5.512961e-01 0.259 0 0
Translesion synthesis by POLI R-HSA-5656121 5.518814e-01 0.258 0 0
Phosphorylation of the APC/C R-HSA-176412 5.518814e-01 0.258 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.518814e-01 0.258 0 0
Prolonged ERK activation events R-HSA-169893 5.518814e-01 0.258 0 0
Negative regulation of FLT3 R-HSA-9706369 5.518814e-01 0.258 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.523752e-01 0.258 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.544964e-01 0.256 0 0
Heme signaling R-HSA-9707616 5.567357e-01 0.254 0 0
Signaling by NOTCH3 R-HSA-9012852 5.582447e-01 0.253 0 0
GPER1 signaling R-HSA-9634597 5.601240e-01 0.252 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.602389e-01 0.252 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.602389e-01 0.252 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.602389e-01 0.252 0 0
Formation of apoptosome R-HSA-111458 5.602389e-01 0.252 0 0
PI3K/AKT activation R-HSA-198203 5.602389e-01 0.252 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.602389e-01 0.252 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.602389e-01 0.252 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.602389e-01 0.252 0 0
Pexophagy R-HSA-9664873 5.602389e-01 0.252 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.602389e-01 0.252 0 0
Ribosome-associated quality control R-HSA-9948299 5.623540e-01 0.250 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.651931e-01 0.248 0 0
PERK regulates gene expression R-HSA-381042 5.656086e-01 0.247 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.660154e-01 0.247 0 0
Signaling by Erythropoietin R-HSA-9006335 5.697809e-01 0.244 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.697809e-01 0.244 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.697809e-01 0.244 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.697809e-01 0.244 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.724599e-01 0.242 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.744879e-01 0.241 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.756796e-01 0.240 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.769217e-01 0.239 0 0
Signaling by FGFR1 R-HSA-5654736 5.769217e-01 0.239 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.787584e-01 0.238 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.787584e-01 0.238 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.789257e-01 0.237 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.798758e-01 0.237 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.798758e-01 0.237 0 0
Defective MAT1A causes MATD R-HSA-5579024 5.798758e-01 0.237 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.798758e-01 0.237 0 0
Alanine metabolism R-HSA-8964540 5.798758e-01 0.237 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.798758e-01 0.237 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.798758e-01 0.237 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.846779e-01 0.233 0 0
Phase 2 - plateau phase R-HSA-5576893 5.846779e-01 0.233 0 0
Translesion synthesis by POLK R-HSA-5655862 5.846779e-01 0.233 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.846779e-01 0.233 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.846779e-01 0.233 0 0
Disorders of Developmental Biology R-HSA-9675151 5.846779e-01 0.233 0 0
RNA Polymerase I Transcription R-HSA-73864 5.867583e-01 0.232 0 0
HSF1 activation R-HSA-3371511 5.882747e-01 0.230 0 0
GPVI-mediated activation cascade R-HSA-114604 5.882747e-01 0.230 0 0
Ion transport by P-type ATPases R-HSA-936837 5.919276e-01 0.228 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.944778e-01 0.226 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.944778e-01 0.226 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.944778e-01 0.226 0 0
Regulation of CDH1 Function R-HSA-9764561 5.952378e-01 0.225 0 0
PI3K Cascade R-HSA-109704 5.992274e-01 0.222 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 6.003299e-01 0.222 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.003299e-01 0.222 0 0
FGFR2b ligand binding and activation R-HSA-190377 6.003299e-01 0.222 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 6.003299e-01 0.222 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.003299e-01 0.222 0 0
Formation of the posterior neural plate R-HSA-9832991 6.003299e-01 0.222 0 0
Transport of RCbl within the body R-HSA-9758890 6.003299e-01 0.222 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.103101e-01 0.214 0 0
Ovarian tumor domain proteases R-HSA-5689896 6.103101e-01 0.214 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.158993e-01 0.210 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.158993e-01 0.210 0 0
Glucose metabolism R-HSA-70326 6.162990e-01 0.210 0 0
Vesicle-mediated transport R-HSA-5653656 6.165730e-01 0.210 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 6.183638e-01 0.209 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 6.183638e-01 0.209 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.183638e-01 0.209 0 0
Ca2+ pathway R-HSA-4086398 6.215850e-01 0.206 0 0
Selenoamino acid metabolism R-HSA-2408522 6.272819e-01 0.203 0 0
Immune System R-HSA-168256 6.289740e-01 0.201 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.293657e-01 0.201 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.293657e-01 0.201 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.293657e-01 0.201 0 0
Extension of Telomeres R-HSA-180786 6.306794e-01 0.200 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.312408e-01 0.200 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.316755e-01 0.200 0 0
Activation of AMPA receptors R-HSA-399710 6.364253e-01 0.196 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.364253e-01 0.196 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.364253e-01 0.196 0 0
Defective F9 activation R-HSA-9673221 6.364253e-01 0.196 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.364253e-01 0.196 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.364253e-01 0.196 0 0
Activation of AKT2 R-HSA-165158 6.364253e-01 0.196 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.364253e-01 0.196 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.364253e-01 0.196 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.364253e-01 0.196 0 0
Suppression of autophagy R-HSA-9636569 6.364253e-01 0.196 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.364253e-01 0.196 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.364253e-01 0.196 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 6.364253e-01 0.196 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.375990e-01 0.195 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 6.375990e-01 0.195 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.375990e-01 0.195 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.375990e-01 0.195 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.375990e-01 0.195 0 0
ERKs are inactivated R-HSA-202670 6.375990e-01 0.195 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.375990e-01 0.195 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.375990e-01 0.195 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.375990e-01 0.195 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.375990e-01 0.195 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.375990e-01 0.195 0 0
Cellular response to starvation R-HSA-9711097 6.395819e-01 0.194 0 0
G0 and Early G1 R-HSA-1538133 6.413960e-01 0.193 0 0
Interferon Signaling R-HSA-913531 6.419880e-01 0.192 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.435784e-01 0.191 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.435784e-01 0.191 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.454925e-01 0.190 0 0
GAB1 signalosome R-HSA-180292 6.454925e-01 0.190 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.454925e-01 0.190 0 0
Tie2 Signaling R-HSA-210993 6.454925e-01 0.190 0 0
Interferon gamma signaling R-HSA-877300 6.501770e-01 0.187 0 0
Stabilization of p53 R-HSA-69541 6.523388e-01 0.186 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.544088e-01 0.184 0 0
Smooth Muscle Contraction R-HSA-445355 6.544088e-01 0.184 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.545138e-01 0.184 0 0
Transcription of the HIV genome R-HSA-167172 6.581033e-01 0.182 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.631841e-01 0.178 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.635417e-01 0.178 0 0
Nuclear RNA decay R-HSA-9930044 6.635417e-01 0.178 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.643848e-01 0.178 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.671997e-01 0.176 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.684307e-01 0.175 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.720795e-01 0.173 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 6.720795e-01 0.173 0 0
Interleukin-15 signaling R-HSA-8983432 6.720795e-01 0.173 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.720795e-01 0.173 0 0
Regulation of IFNG signaling R-HSA-877312 6.720795e-01 0.173 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.720795e-01 0.173 0 0
Disorders of Nervous System Development R-HSA-9697154 6.720795e-01 0.173 0 0
Pervasive developmental disorders R-HSA-9005895 6.720795e-01 0.173 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.722747e-01 0.172 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.722747e-01 0.172 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.734313e-01 0.172 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.734313e-01 0.172 0 0
Maturation of nucleoprotein R-HSA-9694631 6.734313e-01 0.172 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.784896e-01 0.168 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.784896e-01 0.168 0 0
Myogenesis R-HSA-525793 6.784896e-01 0.168 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.784896e-01 0.168 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.784896e-01 0.168 0 0
rRNA processing R-HSA-72312 6.794581e-01 0.168 0 0
TCR signaling R-HSA-202403 6.842154e-01 0.165 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.847772e-01 0.164 0 0
TRAIL signaling R-HSA-75158 6.853660e-01 0.164 0 0
PKB-mediated events R-HSA-109703 6.853660e-01 0.164 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.853660e-01 0.164 0 0
PDE3B signalling R-HSA-165160 6.853660e-01 0.164 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.853660e-01 0.164 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.853660e-01 0.164 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.853660e-01 0.164 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.853660e-01 0.164 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.853660e-01 0.164 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.853660e-01 0.164 0 0
Terminal pathway of complement R-HSA-166665 6.853660e-01 0.164 0 0
Signaling by MST1 R-HSA-8852405 6.853660e-01 0.164 0 0
NGF-independant TRKA activation R-HSA-187024 6.853660e-01 0.164 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.853660e-01 0.164 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.853660e-01 0.164 0 0
Phosphorylation of Emi1 R-HSA-176417 6.853660e-01 0.164 0 0
Formation of the Editosome R-HSA-75094 6.853660e-01 0.164 0 0
Ceramide signalling R-HSA-193681 6.853660e-01 0.164 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.853660e-01 0.164 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.853660e-01 0.164 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.853660e-01 0.164 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.853660e-01 0.164 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.853660e-01 0.164 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.853660e-01 0.164 0 0
G alpha (z) signalling events R-HSA-418597 6.886083e-01 0.162 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.887879e-01 0.162 0 0
Interleukin-17 signaling R-HSA-448424 6.887879e-01 0.162 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.905105e-01 0.161 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.914643e-01 0.160 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.938927e-01 0.159 0 0
NGF-stimulated transcription R-HSA-9031628 6.982159e-01 0.156 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.997126e-01 0.155 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.997126e-01 0.155 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.997126e-01 0.155 0 0
Signaling by NODAL R-HSA-1181150 6.997126e-01 0.155 0 0
Nephrin family interactions R-HSA-373753 6.997126e-01 0.155 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 7.012787e-01 0.154 0 0
Cristae formation R-HSA-8949613 7.012787e-01 0.154 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.012787e-01 0.154 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.034825e-01 0.153 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.034825e-01 0.153 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.034825e-01 0.153 0 0
Acetylcholine binding and downstream events R-HSA-181431 7.038466e-01 0.153 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.038466e-01 0.153 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 7.038466e-01 0.153 0 0
FGFR2c ligand binding and activation R-HSA-190375 7.038466e-01 0.153 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 7.038466e-01 0.153 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.038466e-01 0.153 0 0
FGFR4 ligand binding and activation R-HSA-190322 7.038466e-01 0.153 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 7.038466e-01 0.153 0 0
Frs2-mediated activation R-HSA-170968 7.038466e-01 0.153 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 7.038466e-01 0.153 0 0
FGFR3 mutant receptor activation R-HSA-2033514 7.038466e-01 0.153 0 0
Interleukin-6 signaling R-HSA-1059683 7.038466e-01 0.153 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.038466e-01 0.153 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.038466e-01 0.153 0 0
Signaling by NOTCH2 R-HSA-1980145 7.050878e-01 0.152 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.050878e-01 0.152 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.050878e-01 0.152 0 0
Nuclear import of Rev protein R-HSA-180746 7.050878e-01 0.152 0 0
Signaling by FGFR R-HSA-190236 7.055741e-01 0.151 0 0
Regulation of insulin secretion R-HSA-422356 7.055741e-01 0.151 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.098943e-01 0.149 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.098943e-01 0.149 0 0
Insulin receptor signalling cascade R-HSA-74751 7.113997e-01 0.148 0 0
Degradation of CDH1 R-HSA-9766229 7.151530e-01 0.146 0 0
Adipogenesis R-HSA-9843745 7.171985e-01 0.144 0 0
IRS-mediated signalling R-HSA-112399 7.205963e-01 0.142 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.228779e-01 0.141 0 0
Lagging Strand Synthesis R-HSA-69186 7.243521e-01 0.140 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.244662e-01 0.140 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.244662e-01 0.140 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.244662e-01 0.140 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.275571e-01 0.138 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.277212e-01 0.138 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.277212e-01 0.138 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.277212e-01 0.138 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.277212e-01 0.138 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.277212e-01 0.138 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.277212e-01 0.138 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.277212e-01 0.138 0 0
Abacavir transmembrane transport R-HSA-2161517 7.277212e-01 0.138 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 7.277212e-01 0.138 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.277212e-01 0.138 0 0
Lipid particle organization R-HSA-8964572 7.277212e-01 0.138 0 0
Leukotriene receptors R-HSA-391906 7.277212e-01 0.138 0 0
VLDL assembly R-HSA-8866423 7.277212e-01 0.138 0 0
Nef and signal transduction R-HSA-164944 7.277212e-01 0.138 0 0
CREB3 factors activate genes R-HSA-8874211 7.277212e-01 0.138 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.330061e-01 0.135 0 0
Removal of the Flap Intermediate R-HSA-69166 7.330061e-01 0.135 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.330061e-01 0.135 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.330061e-01 0.135 0 0
Prolactin receptor signaling R-HSA-1170546 7.330061e-01 0.135 0 0
HDL assembly R-HSA-8963896 7.330061e-01 0.135 0 0
FGFR3c ligand binding and activation R-HSA-190372 7.330061e-01 0.135 0 0
Malate-aspartate shuttle R-HSA-9856872 7.330061e-01 0.135 0 0
Physiological factors R-HSA-5578768 7.330061e-01 0.135 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.330061e-01 0.135 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.335652e-01 0.135 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.348597e-01 0.134 0 0
DNA Replication R-HSA-69306 7.356926e-01 0.133 0 0
Dual incision in TC-NER R-HSA-6782135 7.357397e-01 0.133 0 0
Hemostasis R-HSA-109582 7.393270e-01 0.131 0 0
FGFR2 mutant receptor activation R-HSA-1839126 7.429121e-01 0.129 0 0
mRNA Capping R-HSA-72086 7.432947e-01 0.129 0 0
Signaling by NOTCH4 R-HSA-9013694 7.448801e-01 0.128 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.473812e-01 0.126 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.473812e-01 0.126 0 0
Neutrophil degranulation R-HSA-6798695 7.487714e-01 0.126 0 0
Toll-like Receptor Cascades R-HSA-168898 7.542294e-01 0.122 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.577689e-01 0.120 0 0
G alpha (q) signalling events R-HSA-416476 7.588762e-01 0.120 0 0
Erythropoietin activates RAS R-HSA-9027284 7.596841e-01 0.119 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.596841e-01 0.119 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.596841e-01 0.119 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.596841e-01 0.119 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.596841e-01 0.119 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.596841e-01 0.119 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.596841e-01 0.119 0 0
FGFR3 ligand binding and activation R-HSA-190239 7.596841e-01 0.119 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.596841e-01 0.119 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.596841e-01 0.119 0 0
Signaling by Activin R-HSA-1502540 7.596841e-01 0.119 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.604313e-01 0.119 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.617284e-01 0.118 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 7.625448e-01 0.118 0 0
DAP12 signaling R-HSA-2424491 7.625448e-01 0.118 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.625448e-01 0.118 0 0
GABA receptor activation R-HSA-977443 7.643086e-01 0.117 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.643768e-01 0.117 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.643768e-01 0.117 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.643768e-01 0.117 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.643768e-01 0.117 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.643768e-01 0.117 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.643768e-01 0.117 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.643768e-01 0.117 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.643768e-01 0.117 0 0
PTK6 Expression R-HSA-8849473 7.643768e-01 0.117 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.643768e-01 0.117 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.643768e-01 0.117 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.643768e-01 0.117 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.643768e-01 0.117 0 0
LDL remodeling R-HSA-8964041 7.643768e-01 0.117 0 0
Activation of TRKA receptors R-HSA-187015 7.643768e-01 0.117 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.643768e-01 0.117 0 0
Glycoprotein hormones R-HSA-209822 7.643768e-01 0.117 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.643768e-01 0.117 0 0
Maturation of replicase proteins R-HSA-9694301 7.643768e-01 0.117 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.671031e-01 0.115 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.688435e-01 0.114 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.688435e-01 0.114 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.688435e-01 0.114 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.688435e-01 0.114 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 7.688435e-01 0.114 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.697755e-01 0.114 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.711002e-01 0.113 0 0
HIV Life Cycle R-HSA-162587 7.715160e-01 0.113 0 0
G alpha (s) signalling events R-HSA-418555 7.723236e-01 0.112 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.759371e-01 0.110 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.759371e-01 0.110 0 0
Budding and maturation of HIV virion R-HSA-162588 7.806518e-01 0.108 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.806518e-01 0.108 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.812593e-01 0.107 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 7.840204e-01 0.106 0 0
Killing mechanisms R-HSA-9664420 7.840204e-01 0.106 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.840204e-01 0.106 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.840204e-01 0.106 0 0
Differentiation of T cells R-HSA-9945266 7.840204e-01 0.106 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.840204e-01 0.106 0 0
Regulation of BACH1 activity R-HSA-9708530 7.840204e-01 0.106 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 7.840204e-01 0.106 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.840204e-01 0.106 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.840204e-01 0.106 0 0
Activation of SMO R-HSA-5635838 7.840204e-01 0.106 0 0
GPCR downstream signalling R-HSA-388396 7.873173e-01 0.104 0 0
Inositol phosphate metabolism R-HSA-1483249 7.875737e-01 0.104 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.887926e-01 0.103 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.887926e-01 0.103 0 0
Syndecan interactions R-HSA-3000170 7.887926e-01 0.103 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.905464e-01 0.102 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.905464e-01 0.102 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.927394e-01 0.101 0 0
HCMV Early Events R-HSA-9609690 7.928373e-01 0.101 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.960994e-01 0.099 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.960994e-01 0.099 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.960994e-01 0.099 0 0
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 7.960994e-01 0.099 0 0
Interleukin-9 signaling R-HSA-8985947 7.960994e-01 0.099 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.960994e-01 0.099 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.960994e-01 0.099 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.960994e-01 0.099 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.960994e-01 0.099 0 0
Sodium/Proton exchangers R-HSA-425986 7.960994e-01 0.099 0 0
Interleukin-23 signaling R-HSA-9020933 7.960994e-01 0.099 0 0
Alpha-defensins R-HSA-1462054 7.960994e-01 0.099 0 0
PTEN Regulation R-HSA-6807070 8.015507e-01 0.096 0 0
Hedgehog 'on' state R-HSA-5632684 8.035388e-01 0.095 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.044153e-01 0.095 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.061616e-01 0.094 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.061616e-01 0.094 0 0
Synthesis of PG R-HSA-1483148 8.061616e-01 0.094 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.061616e-01 0.094 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.065701e-01 0.093 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.072895e-01 0.093 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.072895e-01 0.093 0 0
Complex III assembly R-HSA-9865881 8.072895e-01 0.093 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.075642e-01 0.093 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.075642e-01 0.093 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.075642e-01 0.093 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.075642e-01 0.093 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.075642e-01 0.093 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.075642e-01 0.093 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.075642e-01 0.093 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.135584e-01 0.090 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.153771e-01 0.089 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.154648e-01 0.089 0 0
Intraflagellar transport R-HSA-5620924 8.175590e-01 0.087 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.215327e-01 0.085 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.235527e-01 0.084 0 0
Interleukin-21 signaling R-HSA-9020958 8.235527e-01 0.084 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.235527e-01 0.084 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.235527e-01 0.084 0 0
Degradation of GABA R-HSA-916853 8.235527e-01 0.084 0 0
MAPK1 (ERK2) activation R-HSA-112411 8.235527e-01 0.084 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.235527e-01 0.084 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.235527e-01 0.084 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 8.235527e-01 0.084 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.235527e-01 0.084 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.235527e-01 0.084 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.244001e-01 0.084 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.244001e-01 0.084 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.244001e-01 0.084 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.244001e-01 0.084 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.244001e-01 0.084 0 0
G protein gated Potassium channels R-HSA-1296059 8.244001e-01 0.084 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.244001e-01 0.084 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.244001e-01 0.084 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.262578e-01 0.083 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.262578e-01 0.083 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.262578e-01 0.083 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.262578e-01 0.083 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.262578e-01 0.083 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.262578e-01 0.083 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.262578e-01 0.083 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.272858e-01 0.082 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.284308e-01 0.082 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.284308e-01 0.082 0 0
HCMV Late Events R-HSA-9610379 8.304817e-01 0.081 0 0
Interferon alpha/beta signaling R-HSA-909733 8.320076e-01 0.080 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.327421e-01 0.079 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.346708e-01 0.078 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.346708e-01 0.078 0 0
HIV Transcription Initiation R-HSA-167161 8.346708e-01 0.078 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.346708e-01 0.078 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.346708e-01 0.078 0 0
Signaling by FGFR in disease R-HSA-1226099 8.355441e-01 0.078 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.374500e-01 0.077 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.401944e-01 0.076 0 0
Host Interactions of HIV factors R-HSA-162909 8.415828e-01 0.075 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.423033e-01 0.075 0 0
Activated point mutants of FGFR2 R-HSA-2033519 8.444580e-01 0.073 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 8.444580e-01 0.073 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.444580e-01 0.073 0 0
Kidney development R-HSA-9830369 8.466511e-01 0.072 0 0
Activation of GABAB receptors R-HSA-991365 8.470070e-01 0.072 0 0
GABA B receptor activation R-HSA-977444 8.470070e-01 0.072 0 0
Binding and entry of HIV virion R-HSA-173107 8.473111e-01 0.072 0 0
2-LTR circle formation R-HSA-164843 8.473111e-01 0.072 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 8.473111e-01 0.072 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.473111e-01 0.072 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.473111e-01 0.072 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.473111e-01 0.072 0 0
Maturation of spike protein R-HSA-9683686 8.473111e-01 0.072 0 0
Sperm Motility And Taxes R-HSA-1300642 8.473111e-01 0.072 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.473111e-01 0.072 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.473111e-01 0.072 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.473111e-01 0.072 0 0
Peptide hormone biosynthesis R-HSA-209952 8.473111e-01 0.072 0 0
Josephin domain DUBs R-HSA-5689877 8.473111e-01 0.072 0 0
Serotonin receptors R-HSA-390666 8.473111e-01 0.072 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.473111e-01 0.072 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.490450e-01 0.071 0 0
Regulation of beta-cell development R-HSA-186712 8.490450e-01 0.071 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.490450e-01 0.071 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.528242e-01 0.069 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.562897e-01 0.067 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.585710e-01 0.066 0 0
Parasitic Infection Pathways R-HSA-9824443 8.589917e-01 0.066 0 0
Leishmania infection R-HSA-9658195 8.589917e-01 0.066 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.601615e-01 0.065 0 0
Regulation of signaling by CBL R-HSA-912631 8.609085e-01 0.065 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.609085e-01 0.065 0 0
Translesion Synthesis by POLH R-HSA-110320 8.609085e-01 0.065 0 0
Diseases of hemostasis R-HSA-9671793 8.609085e-01 0.065 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.609085e-01 0.065 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.609085e-01 0.065 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.609085e-01 0.065 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.609085e-01 0.065 0 0
IRE1alpha activates chaperones R-HSA-381070 8.612975e-01 0.065 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.632610e-01 0.064 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.632610e-01 0.064 0 0
G1/S-Specific Transcription R-HSA-69205 8.672238e-01 0.062 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.672238e-01 0.062 0 0
Triglyceride catabolism R-HSA-163560 8.672238e-01 0.062 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.678716e-01 0.062 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.678716e-01 0.062 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.678716e-01 0.062 0 0
vRNP Assembly R-HSA-192905 8.678716e-01 0.062 0 0
vRNA Synthesis R-HSA-192814 8.678716e-01 0.062 0 0
Chylomicron assembly R-HSA-8963888 8.678716e-01 0.062 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.678716e-01 0.062 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.678716e-01 0.062 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.678716e-01 0.062 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.678716e-01 0.062 0 0
Suppression of apoptosis R-HSA-9635465 8.678716e-01 0.062 0 0
Prostanoid ligand receptors R-HSA-391908 8.678716e-01 0.062 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.681214e-01 0.061 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.685627e-01 0.061 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.693942e-01 0.061 0 0
Gap junction trafficking R-HSA-190828 8.693942e-01 0.061 0 0
Platelet degranulation R-HSA-114608 8.697340e-01 0.061 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.714677e-01 0.060 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.730770e-01 0.059 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.757503e-01 0.058 0 0
Negative regulation of MET activity R-HSA-6807004 8.757503e-01 0.058 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.757503e-01 0.058 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.757503e-01 0.058 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.765897e-01 0.057 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.775143e-01 0.057 0 0
Signaling by PDGF R-HSA-186797 8.775143e-01 0.057 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.775143e-01 0.057 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.778221e-01 0.057 0 0
Gastrulation R-HSA-9758941 8.783623e-01 0.056 0 0
Degradation of DVL R-HSA-4641258 8.783624e-01 0.056 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.795087e-01 0.056 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.795087e-01 0.056 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.803991e-01 0.055 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.803991e-01 0.055 0 0
Interleukin-1 signaling R-HSA-9020702 8.827567e-01 0.054 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.851557e-01 0.053 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.856646e-01 0.053 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.856646e-01 0.053 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.856646e-01 0.053 0 0
Integration of provirus R-HSA-162592 8.856646e-01 0.053 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.884292e-01 0.051 0 0
MET promotes cell motility R-HSA-8875878 8.886812e-01 0.051 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.889470e-01 0.051 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.889470e-01 0.051 0 0
FGFR2 ligand binding and activation R-HSA-190241 8.891183e-01 0.051 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.891183e-01 0.051 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.891183e-01 0.051 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.891183e-01 0.051 0 0
HIV Infection R-HSA-162906 8.904428e-01 0.050 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.909439e-01 0.050 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.916485e-01 0.050 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.977419e-01 0.047 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.990445e-01 0.046 0 0
Scavenging by Class F Receptors R-HSA-3000484 9.010623e-01 0.045 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 9.010623e-01 0.045 0 0
IRAK1 recruits IKK complex R-HSA-937039 9.010623e-01 0.045 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 9.010623e-01 0.045 0 0
GRB2 events in EGFR signaling R-HSA-179812 9.010623e-01 0.045 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.010623e-01 0.045 0 0
MET activates RAS signaling R-HSA-8851805 9.010623e-01 0.045 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 9.010623e-01 0.045 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.010623e-01 0.045 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 9.010623e-01 0.045 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 9.010623e-01 0.045 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 9.010623e-01 0.045 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 9.010623e-01 0.045 0 0
Estrogen biosynthesis R-HSA-193144 9.010623e-01 0.045 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 9.010623e-01 0.045 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.011402e-01 0.045 0 0
Signaling by PDGFR in disease R-HSA-9671555 9.011402e-01 0.045 0 0
Cellular response to hypoxia R-HSA-1234174 9.013719e-01 0.045 0 0
Cargo concentration in the ER R-HSA-5694530 9.019393e-01 0.045 0 0
G1/S Transition R-HSA-69206 9.047587e-01 0.043 0 0
Neurotransmitter release cycle R-HSA-112310 9.050157e-01 0.043 0 0
Metal ion SLC transporters R-HSA-425410 9.059263e-01 0.043 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.077170e-01 0.042 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.108016e-01 0.041 0 0
Protein ubiquitination R-HSA-8852135 9.108016e-01 0.041 0 0
DNA strand elongation R-HSA-69190 9.113389e-01 0.040 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.119361e-01 0.040 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.119361e-01 0.040 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.119361e-01 0.040 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.119361e-01 0.040 0 0
LDL clearance R-HSA-8964038 9.119361e-01 0.040 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.119361e-01 0.040 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.135326e-01 0.039 0 0
Gap junction trafficking and regulation R-HSA-157858 9.135326e-01 0.039 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 9.143872e-01 0.039 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 9.143872e-01 0.039 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.143872e-01 0.039 0 0
Chylomicron remodeling R-HSA-8963901 9.143872e-01 0.039 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.143872e-01 0.039 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.143872e-01 0.039 0 0
Processing of SMDT1 R-HSA-8949664 9.143872e-01 0.039 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.143872e-01 0.039 0 0
CD28 dependent Vav1 pathway R-HSA-389359 9.143872e-01 0.039 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.143872e-01 0.039 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.151727e-01 0.038 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.199122e-01 0.036 0 0
Triglyceride metabolism R-HSA-8979227 9.203159e-01 0.036 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.205926e-01 0.036 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.216181e-01 0.035 0 0
Protein folding R-HSA-391251 9.219149e-01 0.035 0 0
Signaling by Insulin receptor R-HSA-74752 9.219149e-01 0.035 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.226624e-01 0.035 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.226624e-01 0.035 0 0
Translation of Structural Proteins R-HSA-9683701 9.226624e-01 0.035 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.259182e-01 0.033 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.259182e-01 0.033 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.259182e-01 0.033 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.259182e-01 0.033 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.259182e-01 0.033 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.259182e-01 0.033 0 0
P2Y receptors R-HSA-417957 9.259182e-01 0.033 0 0
Zinc transporters R-HSA-435354 9.259182e-01 0.033 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.264786e-01 0.033 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.271376e-01 0.033 0 0
The phototransduction cascade R-HSA-2514856 9.271376e-01 0.033 0 0
Heme degradation R-HSA-189483 9.277212e-01 0.033 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.295523e-01 0.032 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.297528e-01 0.032 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.300004e-01 0.032 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.302903e-01 0.031 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.302903e-01 0.031 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.302903e-01 0.031 0 0
Interleukin-6 family signaling R-HSA-6783589 9.302903e-01 0.031 0 0
Collagen formation R-HSA-1474290 9.316968e-01 0.031 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.331981e-01 0.030 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.331981e-01 0.030 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.348248e-01 0.029 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.348248e-01 0.029 0 0
eNOS activation R-HSA-203615 9.348248e-01 0.029 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.358828e-01 0.029 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.358966e-01 0.029 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.358966e-01 0.029 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.358966e-01 0.029 0 0
Protein lipoylation R-HSA-9857492 9.358966e-01 0.029 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.358966e-01 0.029 0 0
Protein repair R-HSA-5676934 9.358966e-01 0.029 0 0
Biotin transport and metabolism R-HSA-196780 9.358966e-01 0.029 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.358966e-01 0.029 0 0
Other semaphorin interactions R-HSA-416700 9.358966e-01 0.029 0 0
DNA Damage Reversal R-HSA-73942 9.358966e-01 0.029 0 0
Phospholipid metabolism R-HSA-1483257 9.375314e-01 0.028 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.375568e-01 0.028 0 0
Signaling by MET R-HSA-6806834 9.379578e-01 0.028 0 0
Hyaluronan degradation R-HSA-2160916 9.380490e-01 0.028 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.380490e-01 0.028 0 0
Mitochondrial biogenesis R-HSA-1592230 9.383639e-01 0.028 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.388034e-01 0.027 0 0
DAP12 interactions R-HSA-2172127 9.416922e-01 0.026 0 0
HCMV Infection R-HSA-9609646 9.427006e-01 0.026 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.443815e-01 0.025 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.445316e-01 0.025 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.445316e-01 0.025 0 0
Fructose catabolism R-HSA-70350 9.445316e-01 0.025 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.445316e-01 0.025 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.445316e-01 0.025 0 0
Attachment and Entry R-HSA-9678110 9.445316e-01 0.025 0 0
Atorvastatin ADME R-HSA-9754706 9.445316e-01 0.025 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.449830e-01 0.025 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.471360e-01 0.024 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.471360e-01 0.024 0 0
RNA Polymerase III Transcription R-HSA-74158 9.471360e-01 0.024 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.471360e-01 0.024 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.487617e-01 0.023 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.511735e-01 0.022 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.511735e-01 0.022 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.511735e-01 0.022 0 0
Signaling by BMP R-HSA-201451 9.511735e-01 0.022 0 0
Triglyceride biosynthesis R-HSA-75109 9.511735e-01 0.022 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.511735e-01 0.022 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.520038e-01 0.021 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.520038e-01 0.021 0 0
Glycine degradation R-HSA-6783984 9.520038e-01 0.021 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.520038e-01 0.021 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.520038e-01 0.021 0 0
Coenzyme A biosynthesis R-HSA-196783 9.520038e-01 0.021 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.520038e-01 0.021 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.524454e-01 0.021 0 0
Signaling by GPCR R-HSA-372790 9.558699e-01 0.020 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.563537e-01 0.019 0 0
Pyrimidine salvage R-HSA-73614 9.566951e-01 0.019 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.567777e-01 0.019 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.572531e-01 0.019 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.584697e-01 0.018 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.584697e-01 0.018 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.584697e-01 0.018 0 0
Catecholamine biosynthesis R-HSA-209905 9.584697e-01 0.018 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.584697e-01 0.018 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.584697e-01 0.018 0 0
Choline catabolism R-HSA-6798163 9.584697e-01 0.018 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.607500e-01 0.017 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.609610e-01 0.017 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.616021e-01 0.017 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.616021e-01 0.017 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.616021e-01 0.017 0 0
Glucagon-type ligand receptors R-HSA-420092 9.616155e-01 0.017 0 0
PPARA activates gene expression R-HSA-1989781 9.629949e-01 0.016 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.640650e-01 0.016 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.640650e-01 0.016 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.640650e-01 0.016 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.640650e-01 0.016 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.640650e-01 0.016 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.640650e-01 0.016 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.640650e-01 0.016 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.640650e-01 0.016 0 0
PCP/CE pathway R-HSA-4086400 9.643280e-01 0.016 0 0
Glycogen metabolism R-HSA-8982491 9.655324e-01 0.015 0 0
Activation of the pre-replicative complex R-HSA-68962 9.659965e-01 0.015 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.659965e-01 0.015 0 0
Neurotransmitter clearance R-HSA-112311 9.659965e-01 0.015 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.671676e-01 0.014 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.671907e-01 0.014 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.689066e-01 0.014 0 0
Pyrimidine biosynthesis R-HSA-500753 9.689066e-01 0.014 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.689066e-01 0.014 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.689066e-01 0.014 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.689066e-01 0.014 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.689066e-01 0.014 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.690809e-01 0.014 0 0
Maturation of spike protein R-HSA-9694548 9.690809e-01 0.014 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.698942e-01 0.013 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.698942e-01 0.013 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.722377e-01 0.012 0 0
tRNA processing in the nucleus R-HSA-6784531 9.730924e-01 0.012 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.730962e-01 0.012 0 0
Keratan sulfate degradation R-HSA-2022857 9.730962e-01 0.012 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.730962e-01 0.012 0 0
Pregnenolone biosynthesis R-HSA-196108 9.730962e-01 0.012 0 0
Signal transduction by L1 R-HSA-445144 9.730962e-01 0.012 0 0
Downstream TCR signaling R-HSA-202424 9.736498e-01 0.012 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.758156e-01 0.011 0 0
Nucleotide biosynthesis R-HSA-8956320 9.760074e-01 0.011 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.764371e-01 0.010 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.767215e-01 0.010 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.767215e-01 0.010 0 0
G-protein activation R-HSA-202040 9.767215e-01 0.010 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.767215e-01 0.010 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.767215e-01 0.010 0 0
Phenylalanine metabolism R-HSA-8964208 9.767215e-01 0.010 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.767215e-01 0.010 0 0
Basigin interactions R-HSA-210991 9.767215e-01 0.010 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.777649e-01 0.010 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.777649e-01 0.010 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.779745e-01 0.010 0 0
Neddylation R-HSA-8951664 9.785496e-01 0.009 0 0
SARS-CoV Infections R-HSA-9679506 9.791410e-01 0.009 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.791696e-01 0.009 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.791696e-01 0.009 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.791696e-01 0.009 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.791696e-01 0.009 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.791696e-01 0.009 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.791922e-01 0.009 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.793947e-01 0.009 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.798137e-01 0.009 0 0
Eicosanoids R-HSA-211979 9.798584e-01 0.009 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.798584e-01 0.009 0 0
Miscellaneous substrates R-HSA-211958 9.798584e-01 0.009 0 0
Assembly Of The HIV Virion R-HSA-175474 9.798584e-01 0.009 0 0
Serine metabolism R-HSA-977347 9.798584e-01 0.009 0 0
Glutathione synthesis and recycling R-HSA-174403 9.798584e-01 0.009 0 0
Attachment and Entry R-HSA-9694614 9.798584e-01 0.009 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.801026e-01 0.009 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.801026e-01 0.009 0 0
Leishmania phagocytosis R-HSA-9664417 9.802412e-01 0.009 0 0
Parasite infection R-HSA-9664407 9.802412e-01 0.009 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.802412e-01 0.009 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.815937e-01 0.008 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.815937e-01 0.008 0 0
Hyaluronan metabolism R-HSA-2142845 9.815937e-01 0.008 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.822046e-01 0.008 0 0
Signaling by KIT in disease R-HSA-9669938 9.825728e-01 0.008 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.825728e-01 0.008 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.825728e-01 0.008 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.825728e-01 0.008 0 0
Fructose metabolism R-HSA-5652084 9.825728e-01 0.008 0 0
Potential therapeutics for SARS R-HSA-9679191 9.829917e-01 0.007 0 0
Translation of Structural Proteins R-HSA-9694635 9.831894e-01 0.007 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.837429e-01 0.007 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.840932e-01 0.007 0 0
Synthesis of PA R-HSA-1483166 9.841009e-01 0.007 0 0
Interleukin-10 signaling R-HSA-6783783 9.846719e-01 0.007 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.849215e-01 0.007 0 0
Fatty acids R-HSA-211935 9.849215e-01 0.007 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.849215e-01 0.007 0 0
Formation of the ureteric bud R-HSA-9830674 9.849215e-01 0.007 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.849215e-01 0.007 0 0
Carnitine shuttle R-HSA-200425 9.849215e-01 0.007 0 0
Biosynthesis of maresins R-HSA-9018682 9.849215e-01 0.007 0 0
Interleukin-20 family signaling R-HSA-8854691 9.849215e-01 0.007 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.857889e-01 0.006 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.869538e-01 0.006 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.869538e-01 0.006 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.873103e-01 0.006 0 0
ER-Phagosome pathway R-HSA-1236974 9.873113e-01 0.006 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.873339e-01 0.006 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.873339e-01 0.006 0 0
Metabolism of folate and pterines R-HSA-196757 9.873339e-01 0.006 0 0
COPII-mediated vesicle transport R-HSA-204005 9.875859e-01 0.005 0 0
tRNA Aminoacylation R-HSA-379724 9.883911e-01 0.005 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.883911e-01 0.005 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.887123e-01 0.005 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.887123e-01 0.005 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.887123e-01 0.005 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.887123e-01 0.005 0 0
Fertilization R-HSA-1187000 9.887123e-01 0.005 0 0
Laminin interactions R-HSA-3000157 9.887123e-01 0.005 0 0
Elastic fibre formation R-HSA-1566948 9.888266e-01 0.005 0 0
Synthesis of DNA R-HSA-69239 9.889584e-01 0.005 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.895573e-01 0.005 0 0
Circadian clock R-HSA-9909396 9.897082e-01 0.004 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.898441e-01 0.004 0 0
Pentose phosphate pathway R-HSA-71336 9.901472e-01 0.004 0 0
RAS processing R-HSA-9648002 9.901472e-01 0.004 0 0
MET activates PTK2 signaling R-HSA-8874081 9.902338e-01 0.004 0 0
Urea cycle R-HSA-70635 9.902338e-01 0.004 0 0
Sphingolipid catabolism R-HSA-9845614 9.902338e-01 0.004 0 0
Abacavir ADME R-HSA-2161522 9.902338e-01 0.004 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.902338e-01 0.004 0 0
Mitochondrial protein import R-HSA-1268020 9.906111e-01 0.004 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.909914e-01 0.004 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.911612e-01 0.004 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.913149e-01 0.004 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.915504e-01 0.004 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.915504e-01 0.004 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.915504e-01 0.004 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.915504e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.915504e-01 0.004 0 0
Orc1 removal from chromatin R-HSA-68949 9.919711e-01 0.004 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.923469e-01 0.003 0 0
Mitochondrial protein degradation R-HSA-9837999 9.926441e-01 0.003 0 0
Prednisone ADME R-HSA-9757110 9.926895e-01 0.003 0 0
Insulin receptor recycling R-HSA-77387 9.926895e-01 0.003 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.928474e-01 0.003 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.932586e-01 0.003 0 0
Intra-Golgi traffic R-HSA-6811438 9.932586e-01 0.003 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.936308e-01 0.003 0 0
Thyroxine biosynthesis R-HSA-209968 9.936751e-01 0.003 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.936751e-01 0.003 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.936751e-01 0.003 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.936751e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.938942e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.940636e-01 0.003 0 0
ABC transporter disorders R-HSA-5619084 9.944625e-01 0.002 0 0
Mucopolysaccharidoses R-HSA-2206281 9.945279e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.950895e-01 0.002 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.952029e-01 0.002 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.952657e-01 0.002 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.952657e-01 0.002 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.952657e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.952657e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.953095e-01 0.002 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.953890e-01 0.002 0 0
Surfactant metabolism R-HSA-5683826 9.954010e-01 0.002 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.959041e-01 0.002 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.959539e-01 0.002 0 0
Somitogenesis R-HSA-9824272 9.959539e-01 0.002 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.959539e-01 0.002 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.959539e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.960676e-01 0.002 0 0
ABC-family proteins mediated transport R-HSA-382556 9.961863e-01 0.002 0 0
Recycling of bile acids and salts R-HSA-159418 9.964564e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.964696e-01 0.002 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.967057e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.972035e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.972035e-01 0.001 0 0
Gluconeogenesis R-HSA-70263 9.972495e-01 0.001 0 0
Gap junction assembly R-HSA-190861 9.973478e-01 0.001 0 0
Signal amplification R-HSA-392518 9.973478e-01 0.001 0 0
RA biosynthesis pathway R-HSA-5365859 9.973478e-01 0.001 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.973478e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.974709e-01 0.001 0 0
SLC transporter disorders R-HSA-5619102 9.975219e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.975828e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.977055e-01 0.001 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.977055e-01 0.001 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.977055e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.977055e-01 0.001 0 0
Regulation of Apoptosis R-HSA-169911 9.977055e-01 0.001 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.977055e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.977055e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.977387e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.978416e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.979042e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.980150e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.981346e-01 0.001 0 0
Degradation of AXIN R-HSA-4641257 9.982827e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.982827e-01 0.001 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.982827e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.982827e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.982827e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.982827e-01 0.001 0 0
Viral Infection Pathways R-HSA-9824446 9.983736e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.983873e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.985144e-01 0.001 0 0
Purine salvage R-HSA-74217 9.985144e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.986378e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.987148e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.987148e-01 0.001 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.987640e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.988882e-01 0.000 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.988882e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.988922e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.990280e-01 0.000 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.990382e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.991618e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.991618e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.991680e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.992098e-01 0.000 0 0
RSV-host interactions R-HSA-9833110 9.992233e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.992581e-01 0.000 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.992802e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.993443e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.993550e-01 0.000 0 0
Defensins R-HSA-1461973 9.993774e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.994194e-01 0.000 0 0
Proteasome assembly R-HSA-9907900 9.994614e-01 0.000 0 0
Methylation R-HSA-156581 9.994614e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.994865e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.995970e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.996514e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.996514e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.996514e-01 0.000 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.996867e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.997161e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.997391e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.997391e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997394e-01 0.000 0 0
Protein localization R-HSA-9609507 9.997465e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997724e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.997724e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997724e-01 0.000 0 0
Azathioprine ADME R-HSA-9748787 9.997744e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.997744e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.997949e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.998386e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.998473e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998473e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998664e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998757e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998831e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.998846e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998918e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998977e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.998983e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999021e-01 0.000 0 0
Digestion R-HSA-8935690 9.999055e-01 0.000 0 0
Translation R-HSA-72766 9.999057e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999057e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999057e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999117e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.999183e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999316e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999389e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.999389e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999471e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.999471e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999543e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999543e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999577e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999651e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999658e-01 0.000 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.999658e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999658e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999704e-01 0.000 0 0
Glycosphingolipid biosynthesis R-HSA-9840309 9.999704e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999704e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999716e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999744e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999748e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999748e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999767e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999798e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999805e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999821e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999862e-01 0.000 0 0
tRNA processing R-HSA-72306 9.999865e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999882e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.999893e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999897e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999910e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999920e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999921e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999954e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999959e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999961e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999975e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999983e-01 0.000 0 0
Disease R-HSA-1643685 9.999989e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999994e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999995e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999995e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999996e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999997e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999997e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999998e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999998e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle Checkpoints R-HSA-69620 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.540635e-13 12.123 0 0
G2/M Checkpoints R-HSA-69481 1.257883e-12 11.900 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.421419e-12 11.847 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.438583e-12 11.464 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.278911e-12 11.369 0 0
Metabolism of RNA R-HSA-8953854 4.137468e-12 11.383 0 0
Signal Transduction R-HSA-162582 3.807399e-12 11.419 1 0
Axon guidance R-HSA-422475 6.228573e-12 11.206 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.101964e-12 11.091 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 7.987500e-12 11.098 0 0
Nervous system development R-HSA-9675108 1.238143e-11 10.907 0 0
Cell-Cell communication R-HSA-1500931 1.365064e-11 10.865 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.598011e-11 10.796 0 0
DNA methylation R-HSA-5334118 4.838485e-11 10.315 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.389300e-11 10.268 0 0
Defective pyroptosis R-HSA-9710421 5.016421e-11 10.300 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.364142e-11 10.270 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.646328e-11 10.333 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 5.702394e-11 10.244 0 0
Mitotic Prophase R-HSA-68875 1.110528e-10 9.954 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.165088e-10 9.934 0 0
HDACs deacetylate histones R-HSA-3214815 1.618331e-10 9.791 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.730940e-10 9.762 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.724769e-10 9.565 0 0
HATs acetylate histones R-HSA-3214847 2.584226e-10 9.588 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.651817e-10 9.576 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.015569e-10 9.521 0 0
Cellular Senescence R-HSA-2559583 2.980863e-10 9.526 0 0
Cell junction organization R-HSA-446728 3.150671e-10 9.502 0 0
Cellular responses to stress R-HSA-2262752 3.631068e-10 9.440 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.922621e-10 9.406 0 0
Nucleosome assembly R-HSA-774815 5.696436e-10 9.244 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.696436e-10 9.244 0 0
Packaging Of Telomere Ends R-HSA-171306 7.721337e-10 9.112 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.566677e-10 9.121 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.566677e-10 9.121 0 0
Apoptotic execution phase R-HSA-75153 8.173686e-10 9.088 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.972832e-10 9.047 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.393027e-09 8.856 0 0
Signaling by ROBO receptors R-HSA-376176 1.498907e-09 8.824 0 0
Mitotic Anaphase R-HSA-68882 1.692100e-09 8.772 0 0
Cellular responses to stimuli R-HSA-8953897 1.769514e-09 8.752 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.954214e-09 8.709 0 0
Diseases of programmed cell death R-HSA-9645723 2.067193e-09 8.685 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.260624e-09 8.646 0 0
Mitotic Prometaphase R-HSA-68877 2.377947e-09 8.624 0 0
Apoptosis R-HSA-109581 2.379933e-09 8.623 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.697367e-09 8.569 0 0
Chromatin modifying enzymes R-HSA-3247509 3.216129e-09 8.493 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.578058e-09 8.446 0 0
Chromatin organization R-HSA-4839726 3.849350e-09 8.415 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.758715e-09 8.425 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.985193e-09 8.400 0 0
Meiotic recombination R-HSA-912446 4.420057e-09 8.355 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.460332e-09 8.351 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.265982e-09 8.203 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.299189e-09 8.137 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.113160e-09 8.091 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.183593e-08 7.927 1 1
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.385951e-08 7.858 0 0
Adherens junctions interactions R-HSA-418990 1.453924e-08 7.837 0 0
Programmed Cell Death R-HSA-5357801 1.565761e-08 7.805 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.811104e-08 7.742 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.811104e-08 7.742 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.897593e-08 7.722 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.908817e-08 7.719 0 0
Gene Silencing by RNA R-HSA-211000 2.144739e-08 7.669 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.298280e-08 7.639 0 0
HCMV Early Events R-HSA-9609690 2.528214e-08 7.597 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.610316e-08 7.583 0 0
Meiotic synapsis R-HSA-1221632 3.569152e-08 7.447 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.494076e-08 7.457 0 0
Meiosis R-HSA-1500620 3.773940e-08 7.423 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.069292e-08 7.390 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.587638e-08 7.253 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.680078e-08 7.246 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.695089e-08 7.174 0 0
Separation of Sister Chromatids R-HSA-2467813 6.784189e-08 7.169 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.733319e-08 7.172 0 0
Cell-cell junction organization R-HSA-421270 6.691811e-08 7.174 0 0
Cleavage of the damaged purine R-HSA-110331 7.031367e-08 7.153 0 0
mRNA Splicing R-HSA-72172 8.507082e-08 7.070 0 0
Depurination R-HSA-73927 9.882168e-08 7.005 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.082936e-07 6.965 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.082936e-07 6.965 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.080273e-07 6.966 0 0
Depyrimidination R-HSA-73928 1.080273e-07 6.966 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.121474e-07 6.950 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.502685e-07 6.823 0 0
ESR-mediated signaling R-HSA-8939211 1.585651e-07 6.800 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.718166e-07 6.765 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.830068e-07 6.738 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.862864e-07 6.730 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.125785e-07 6.672 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.144316e-07 6.669 0 0
Ub-specific processing proteases R-HSA-5689880 2.798242e-07 6.553 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.958047e-07 6.529 0 0
Peptide chain elongation R-HSA-156902 2.969093e-07 6.527 0 0
HCMV Infection R-HSA-9609646 3.092828e-07 6.510 0 0
RNA Polymerase I Transcription R-HSA-73864 3.319249e-07 6.479 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.335090e-07 6.477 0 0
DNA Double Strand Break Response R-HSA-5693606 3.463502e-07 6.460 0 0
Chromosome Maintenance R-HSA-73886 3.824416e-07 6.417 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.824416e-07 6.417 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.859071e-07 6.414 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.666215e-07 6.331 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.976430e-07 6.303 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.976430e-07 6.303 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.484635e-07 6.188 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.403542e-07 6.076 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 9.096947e-07 6.041 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.018399e-06 5.992 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.355646e-06 5.868 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.475010e-06 5.831 0 0
Influenza Infection R-HSA-168255 1.488409e-06 5.827 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.517427e-06 5.819 0 0
DNA Replication R-HSA-69306 1.607448e-06 5.794 0 0
mRNA 3'-end processing R-HSA-72187 1.740756e-06 5.759 0 0
Signaling by WNT R-HSA-195721 2.010483e-06 5.697 0 0
Amyloid fiber formation R-HSA-977225 2.006325e-06 5.698 0 0
Reproduction R-HSA-1474165 2.085911e-06 5.681 0 0
Translation initiation complex formation R-HSA-72649 2.820850e-06 5.550 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.820850e-06 5.550 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.847794e-06 5.545 0 0
G2/M Transition R-HSA-69275 3.454785e-06 5.462 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.523809e-06 5.453 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.354705e-06 5.361 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.477342e-06 5.349 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.922186e-06 5.308 0 0
Signaling by ALK in cancer R-HSA-9700206 4.922186e-06 5.308 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.933461e-06 5.307 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 5.173598e-06 5.286 0 0
Deubiquitination R-HSA-5688426 5.239114e-06 5.281 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.264953e-06 5.203 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.436233e-06 5.191 0 0
HCMV Late Events R-HSA-9610379 6.544861e-06 5.184 0 0
Telomere Maintenance R-HSA-157579 6.572935e-06 5.182 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.969733e-06 5.157 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.222516e-06 5.141 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.434056e-06 5.074 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.434056e-06 5.074 0 0
DNA Double-Strand Break Repair R-HSA-5693532 9.477726e-06 5.023 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.985093e-06 5.001 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.060111e-05 4.975 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.070830e-05 4.970 0 0
Selenocysteine synthesis R-HSA-2408557 1.237757e-05 4.907 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.308504e-05 4.883 0 0
Eukaryotic Translation Termination R-HSA-72764 1.330361e-05 4.876 0 0
Aggrephagy R-HSA-9646399 1.413112e-05 4.850 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.495264e-05 4.825 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.495264e-05 4.825 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.529833e-05 4.815 0 0
Ribosome-associated quality control R-HSA-9948299 1.757538e-05 4.755 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.232096e-05 4.651 0 0
Signaling by NOTCH R-HSA-157118 2.248974e-05 4.648 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.383191e-05 4.623 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.484326e-05 4.605 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.546141e-05 4.594 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.571596e-05 4.590 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.859877e-05 4.544 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.859877e-05 4.544 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.062562e-05 4.514 0 0
Homology Directed Repair R-HSA-5693538 3.195934e-05 4.495 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.455731e-05 4.461 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.338993e-05 4.476 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.569327e-05 4.447 0 0
Co-inhibition by PD-1 R-HSA-389948 3.434450e-05 4.464 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.920977e-05 4.407 0 0
Viral mRNA Translation R-HSA-192823 4.396563e-05 4.357 0 0
rRNA processing R-HSA-72312 4.401506e-05 4.356 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.505124e-05 4.346 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.594661e-05 4.338 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.305535e-05 4.275 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.143022e-05 4.212 0 0
Metalloprotease DUBs R-HSA-5689901 6.600556e-05 4.180 0 0
Interleukin-12 signaling R-HSA-9020591 6.631368e-05 4.178 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.708418e-05 4.173 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.167962e-05 4.145 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.363828e-05 4.078 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 9.580181e-05 4.019 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 9.605323e-05 4.017 0 0
Oncogenic MAPK signaling R-HSA-6802957 9.863757e-05 4.006 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.184230e-04 3.927 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.205760e-04 3.919 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.507293e-04 3.822 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.507293e-04 3.822 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.586623e-04 3.800 0 0
Viral Infection Pathways R-HSA-9824446 1.608956e-04 3.793 0 0
Nuclear import of Rev protein R-HSA-180746 1.732876e-04 3.761 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.871896e-04 3.728 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.882256e-04 3.725 0 0
Activation of BH3-only proteins R-HSA-114452 1.940680e-04 3.712 0 0
Regulation of TP53 Activity R-HSA-5633007 2.259208e-04 3.646 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.310116e-04 3.636 0 0
Base Excision Repair R-HSA-73884 2.325670e-04 3.633 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.350737e-04 3.629 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.350737e-04 3.629 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.350737e-04 3.629 0 0
Signaling by RAS mutants R-HSA-6802949 2.350737e-04 3.629 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.414101e-04 3.617 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.479960e-04 3.606 0 0
Cellular response to heat stress R-HSA-3371556 2.591385e-04 3.586 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.636312e-04 3.579 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.720767e-04 3.565 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.147862e-04 3.502 0 0
HIV Life Cycle R-HSA-162587 3.514116e-04 3.454 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 3.517589e-04 3.454 0 0
Kinesins R-HSA-983189 3.138662e-04 3.503 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.114303e-04 3.507 0 0
Host Interactions of HIV factors R-HSA-162909 3.615734e-04 3.442 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.767790e-04 3.424 0 0
Interleukin-12 family signaling R-HSA-447115 3.896314e-04 3.409 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.947107e-04 3.404 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.089623e-04 3.388 0 0
Protein ubiquitination R-HSA-8852135 4.216386e-04 3.375 0 0
Centrosome maturation R-HSA-380287 4.216386e-04 3.375 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.483221e-04 3.348 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.483221e-04 3.348 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.483221e-04 3.348 0 0
Striated Muscle Contraction R-HSA-390522 4.920438e-04 3.308 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.978160e-04 3.303 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.978160e-04 3.303 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.000805e-04 3.301 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.000805e-04 3.301 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.000805e-04 3.301 0 0
RMTs methylate histone arginines R-HSA-3214858 5.057077e-04 3.296 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.064988e-04 3.295 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.064988e-04 3.295 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.064988e-04 3.295 0 0
Signaling by PTK6 R-HSA-8848021 5.064988e-04 3.295 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.083572e-04 3.294 0 0
Late endosomal microautophagy R-HSA-9615710 5.710568e-04 3.243 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.721565e-04 3.242 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.166507e-04 3.145 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.480287e-04 3.126 0 0
Nephrin family interactions R-HSA-373753 6.936621e-04 3.159 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 7.151559e-04 3.146 0 0
Gene expression (Transcription) R-HSA-74160 6.714292e-04 3.173 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.931883e-04 3.101 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 8.185338e-04 3.087 0 0
Recycling pathway of L1 R-HSA-437239 8.617135e-04 3.065 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 8.918245e-04 3.050 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 8.918245e-04 3.050 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.990934e-04 3.046 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.489156e-04 3.023 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.555023e-04 3.020 0 0
Selective autophagy R-HSA-9663891 1.071752e-03 2.970 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.106915e-03 2.956 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.106915e-03 2.956 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.171340e-03 2.931 0 0
Assembly Of The HIV Virion R-HSA-175474 1.178444e-03 2.929 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.201170e-03 2.920 0 0
DNA Repair R-HSA-73894 1.203269e-03 2.920 0 0
UCH proteinases R-HSA-5689603 1.224390e-03 2.912 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.269135e-03 2.896 0 0
Signaling by Hippo R-HSA-2028269 1.269135e-03 2.896 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.291706e-03 2.889 0 0
Selenoamino acid metabolism R-HSA-2408522 1.313816e-03 2.881 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.349048e-03 2.870 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.349048e-03 2.870 0 0
Semaphorin interactions R-HSA-373755 1.350628e-03 2.869 0 0
HIV Infection R-HSA-162906 1.362405e-03 2.866 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.441892e-03 2.841 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.480001e-03 2.830 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.495143e-03 2.825 0 0
Regulation of CDH1 Function R-HSA-9764561 1.498297e-03 2.824 0 0
Muscle contraction R-HSA-397014 1.505513e-03 2.822 0 0
Cellular response to starvation R-HSA-9711097 1.538680e-03 2.813 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.565167e-03 2.805 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.725797e-03 2.763 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.641169e-03 2.785 0 0
EPH-Ephrin signaling R-HSA-2682334 1.910617e-03 2.719 0 0
Protein folding R-HSA-391251 1.910617e-03 2.719 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.671405e-03 2.777 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.904172e-03 2.720 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.641169e-03 2.785 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.969869e-03 2.706 0 0
RAF activation R-HSA-5673000 1.983012e-03 2.703 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.995544e-03 2.700 0 0
Developmental Biology R-HSA-1266738 2.172175e-03 2.663 0 0
Post NMDA receptor activation events R-HSA-438064 2.207415e-03 2.656 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.332651e-03 2.632 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.332651e-03 2.632 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.437340e-03 2.613 0 0
Autophagy R-HSA-9612973 2.502872e-03 2.602 0 0
MAP2K and MAPK activation R-HSA-5674135 2.660319e-03 2.575 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.709565e-03 2.567 0 0
Negative regulation of MET activity R-HSA-6807004 2.774538e-03 2.557 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.845365e-03 2.546 0 0
EGFR downregulation R-HSA-182971 2.954312e-03 2.530 0 0
tRNA processing in the nucleus R-HSA-6784531 2.991411e-03 2.524 0 0
Membrane Trafficking R-HSA-199991 3.064436e-03 2.514 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.069222e-03 2.513 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.162721e-03 2.500 0 0
L1CAM interactions R-HSA-373760 3.288774e-03 2.483 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.505399e-03 2.455 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.694844e-03 2.432 0 0
Signaling by VEGF R-HSA-194138 3.994339e-03 2.399 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.028339e-03 2.395 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.046415e-03 2.393 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 4.046415e-03 2.393 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.046415e-03 2.393 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.046415e-03 2.393 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.235700e-03 2.373 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.249101e-03 2.372 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.269522e-03 2.370 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.311652e-03 2.365 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.311652e-03 2.365 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.495226e-03 2.347 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.662252e-03 2.331 0 0
Hedgehog 'off' state R-HSA-5610787 4.816820e-03 2.317 0 0
RNA Polymerase II Transcription R-HSA-73857 4.839917e-03 2.315 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.901851e-03 2.310 0 0
Metabolism of non-coding RNA R-HSA-194441 5.003109e-03 2.301 0 0
snRNP Assembly R-HSA-191859 5.003109e-03 2.301 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.045635e-03 2.297 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.290465e-03 2.277 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.420405e-03 2.266 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.649000e-03 2.248 0 0
Ephrin signaling R-HSA-3928664 6.485321e-03 2.188 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.485321e-03 2.188 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 7.131899e-03 2.147 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.798385e-03 2.237 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 6.986491e-03 2.156 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.808792e-03 2.236 0 0
Signaling by NOTCH1 R-HSA-1980143 6.661267e-03 2.176 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.494332e-03 2.187 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.320940e-03 2.199 0 0
Maturation of protein E R-HSA-9683683 7.131899e-03 2.147 0 0
Maturation of protein E R-HSA-9694493 7.131899e-03 2.147 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.307582e-03 2.136 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.026000e-03 2.096 0 0
Folding of actin by CCT/TriC R-HSA-390450 8.026000e-03 2.096 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.077580e-03 2.093 0 0
Regulation of signaling by CBL R-HSA-912631 8.077580e-03 2.093 0 0
G alpha (12/13) signalling events R-HSA-416482 8.208783e-03 2.086 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.946723e-03 2.048 0 0
Budding and maturation of HIV virion R-HSA-162588 8.956762e-03 2.048 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 9.596353e-03 2.018 0 0
Spry regulation of FGF signaling R-HSA-1295596 9.596353e-03 2.018 0 0
p75NTR signals via NF-kB R-HSA-193639 9.596353e-03 2.018 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 9.596353e-03 2.018 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.940553e-03 2.003 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.064948e-02 1.973 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.078681e-02 1.967 0 0
HSF1-dependent transactivation R-HSA-3371571 1.083810e-02 1.965 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.099875e-02 1.959 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.145292e-02 1.941 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.158011e-02 1.936 0 0
Signaling by NOTCH4 R-HSA-9013694 1.177909e-02 1.929 0 0
Prolonged ERK activation events R-HSA-169893 1.209107e-02 1.918 0 0
Negative regulation of FLT3 R-HSA-9706369 1.209107e-02 1.918 0 0
Orc1 removal from chromatin R-HSA-68949 1.221639e-02 1.913 0 0
Stabilization of p53 R-HSA-69541 1.255285e-02 1.901 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.280315e-02 1.893 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.353557e-02 1.869 0 0
Smooth Muscle Contraction R-HSA-445355 1.372525e-02 1.862 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.383668e-02 1.859 0 0
Regulated Necrosis R-HSA-5218859 1.383668e-02 1.859 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.413418e-02 1.850 0 0
NF-kB is activated and signals survival R-HSA-209560 1.413418e-02 1.850 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.457545e-02 1.836 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.457545e-02 1.836 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.500984e-02 1.824 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.500984e-02 1.824 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.500984e-02 1.824 0 0
Regulation of PTEN localization R-HSA-8948747 1.507143e-02 1.822 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.520072e-02 1.818 0 0
S Phase R-HSA-69242 1.521107e-02 1.818 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.535338e-02 1.814 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.535338e-02 1.814 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.535338e-02 1.814 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.535338e-02 1.814 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.535338e-02 1.814 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.535338e-02 1.814 0 0
Cilium Assembly R-HSA-5617833 1.544405e-02 1.811 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.588184e-02 1.799 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.635056e-02 1.786 0 0
Signal amplification R-HSA-392518 1.638318e-02 1.786 0 0
Signaling by NOTCH2 R-HSA-1980145 1.638318e-02 1.786 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.687193e-02 1.773 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.739406e-02 1.760 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.739406e-02 1.760 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.800882e-02 1.745 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.811620e-02 1.742 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.838435e-02 1.736 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.838435e-02 1.736 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.850865e-02 1.733 0 0
Signaling by EGFR R-HSA-177929 1.910912e-02 1.719 0 0
Type I hemidesmosome assembly R-HSA-446107 2.053770e-02 1.687 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.277498e-02 1.643 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.224377e-02 1.653 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.057622e-02 1.687 0 0
Thromboxane signalling through TP receptor R-HSA-428930 2.414236e-02 1.617 0 0
Activation of the pre-replicative complex R-HSA-68962 2.143228e-02 1.669 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.414236e-02 1.617 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.144668e-02 1.669 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.466825e-02 1.608 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.436098e-02 1.613 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.432979e-02 1.614 0 0
Gap junction trafficking R-HSA-190828 2.640003e-02 1.578 0 0
Ca-dependent events R-HSA-111996 2.093893e-02 1.679 0 0
Calmodulin induced events R-HSA-111933 2.144668e-02 1.669 0 0
CaM pathway R-HSA-111997 2.144668e-02 1.669 0 0
Macroautophagy R-HSA-1632852 2.690428e-02 1.570 0 0
Death Receptor Signaling R-HSA-73887 2.216658e-02 1.654 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.234394e-02 1.651 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.053770e-02 1.687 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.053770e-02 1.687 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.093893e-02 1.679 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.661440e-02 1.575 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.053770e-02 1.687 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.708007e-02 1.567 0 0
ARMS-mediated activation R-HSA-170984 2.708007e-02 1.567 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.708007e-02 1.567 0 0
Interleukin-7 signaling R-HSA-1266695 2.811134e-02 1.551 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.814601e-02 1.551 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.814601e-02 1.551 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.814601e-02 1.551 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.855311e-02 1.544 0 0
Signaling by ERBB2 R-HSA-1227986 2.855836e-02 1.544 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.855836e-02 1.544 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.855836e-02 1.544 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.855836e-02 1.544 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.855836e-02 1.544 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.855836e-02 1.544 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.948207e-02 1.530 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.948207e-02 1.530 0 0
MAPK family signaling cascades R-HSA-5683057 2.961867e-02 1.528 0 0
SARS-CoV Infections R-HSA-9679506 3.086425e-02 1.511 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.137241e-02 1.503 0 0
G-protein beta:gamma signalling R-HSA-397795 3.213446e-02 1.493 0 0
Integrin signaling R-HSA-354192 3.213446e-02 1.493 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.213446e-02 1.493 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.213446e-02 1.493 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.250591e-02 1.488 0 0
Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432030 3.250591e-02 1.488 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.250591e-02 1.488 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.425778e-02 1.465 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.425778e-02 1.465 0 0
DCC mediated attractive signaling R-HSA-418885 3.425778e-02 1.465 0 0
Josephin domain DUBs R-HSA-5689877 3.473449e-02 1.459 0 0
Pexophagy R-HSA-9664873 3.473449e-02 1.459 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.639060e-02 1.439 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.697815e-02 1.432 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.697815e-02 1.432 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.697815e-02 1.432 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.726598e-02 1.429 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.750217e-02 1.426 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.819205e-02 1.418 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.883513e-02 1.411 0 0
FLT3 Signaling R-HSA-9607240 3.883513e-02 1.411 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.989505e-02 1.399 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.989505e-02 1.399 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.989505e-02 1.399 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.101064e-02 1.387 0 0
Gap junction assembly R-HSA-190861 4.101064e-02 1.387 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.113160e-02 1.386 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.137782e-02 1.383 0 0
Pyroptosis R-HSA-5620971 4.259644e-02 1.371 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.300690e-02 1.366 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.300690e-02 1.366 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.300690e-02 1.366 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.300690e-02 1.366 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.300690e-02 1.366 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.351941e-02 1.361 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.435490e-02 1.353 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.435490e-02 1.353 0 0
Gap junction trafficking and regulation R-HSA-157858 4.435490e-02 1.353 0 0
Opioid Signalling R-HSA-111885 4.567242e-02 1.340 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.440404e-02 1.264 0 0
Regulation of TP53 Expression R-HSA-6804754 5.440404e-02 1.264 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.440404e-02 1.264 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.440404e-02 1.264 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.440404e-02 1.264 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.440404e-02 1.264 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.440404e-02 1.264 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.440404e-02 1.264 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.440404e-02 1.264 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.440404e-02 1.264 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.440404e-02 1.264 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.440404e-02 1.264 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.819277e-02 1.166 0 0
Activation of RAC1 R-HSA-428540 5.343695e-02 1.272 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.447428e-02 1.191 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 4.878152e-02 1.312 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.878152e-02 1.312 0 0
Deadenylation of mRNA R-HSA-429947 6.461579e-02 1.190 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 6.119934e-02 1.213 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.838125e-02 1.234 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.996886e-02 1.155 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.363335e-02 1.196 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.363335e-02 1.196 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.961779e-02 1.304 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.714430e-02 1.243 0 0
Integration of provirus R-HSA-162592 5.343695e-02 1.272 0 0
HSF1 activation R-HSA-3371511 5.137995e-02 1.289 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.878152e-02 1.312 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.835002e-02 1.165 0 0
Synthesis of DNA R-HSA-69239 5.868577e-02 1.231 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.505521e-02 1.187 0 0
mTORC1-mediated signalling R-HSA-166208 4.961779e-02 1.304 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.832766e-02 1.316 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.996886e-02 1.155 0 0
MTOR signalling R-HSA-165159 4.789894e-02 1.320 0 0
Translation R-HSA-72766 7.083538e-02 1.150 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.138476e-02 1.146 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.119934e-02 1.213 0 0
DAG and IP3 signaling R-HSA-1489509 6.394632e-02 1.194 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.782277e-02 1.238 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.555462e-02 1.255 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 5.440404e-02 1.264 0 0
Netrin-1 signaling R-HSA-373752 5.826303e-02 1.235 0 0
TCR signaling R-HSA-202403 6.998396e-02 1.155 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.447428e-02 1.191 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.103261e-02 1.149 0 0
Nef and signal transduction R-HSA-164944 5.313021e-02 1.275 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.819277e-02 1.166 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.819277e-02 1.166 0 0
Glycogen storage diseases R-HSA-3229121 5.721448e-02 1.242 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.961779e-02 1.304 0 0
Adaptive Immune System R-HSA-1280218 6.163994e-02 1.210 0 0
G1/S Transition R-HSA-69206 7.095349e-02 1.149 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.783902e-02 1.238 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.447428e-02 1.191 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.447428e-02 1.191 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.838125e-02 1.234 0 0
Infectious disease R-HSA-5663205 4.949544e-02 1.305 0 0
Glycolysis R-HSA-70171 6.118038e-02 1.213 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.447428e-02 1.191 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.447428e-02 1.191 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.447428e-02 1.191 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.291545e-02 1.276 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.621144e-02 1.179 0 0
TGFBR3 expression R-HSA-9839394 7.300823e-02 1.137 0 0
Long-term potentiation R-HSA-9620244 7.300823e-02 1.137 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.300823e-02 1.137 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.319201e-02 1.136 0 0
Signaling by MET R-HSA-6806834 7.349862e-02 1.134 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 7.453054e-02 1.128 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.502425e-02 1.125 0 0
Signaling by NOTCH3 R-HSA-9012852 7.502425e-02 1.125 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.598011e-02 1.119 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.633305e-02 1.117 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.642280e-02 1.117 0 0
Translesion Synthesis by POLH R-HSA-110320 7.642280e-02 1.117 0 0
Rap1 signalling R-HSA-392517 7.642280e-02 1.117 0 0
The NLRP3 inflammasome R-HSA-844456 7.642280e-02 1.117 0 0
Frs2-mediated activation R-HSA-170968 7.660518e-02 1.116 0 0
Attenuation phase R-HSA-3371568 7.681443e-02 1.115 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.681443e-02 1.115 0 0
Generation of second messenger molecules R-HSA-202433 7.681443e-02 1.115 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.839609e-02 1.106 0 0
Axonal growth stimulation R-HSA-209563 8.006827e-02 1.097 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 8.006827e-02 1.097 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.116735e-02 1.091 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.116735e-02 1.091 0 0
TNF signaling R-HSA-75893 8.116735e-02 1.091 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.140637e-02 1.089 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.199364e-02 1.086 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 8.199364e-02 1.086 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.199364e-02 1.086 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.199364e-02 1.086 0 0
Formation of annular gap junctions R-HSA-196025 8.495759e-02 1.071 0 0
Adrenoceptors R-HSA-390696 8.495759e-02 1.071 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 8.495759e-02 1.071 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 8.495759e-02 1.071 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.628401e-02 1.064 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.717867e-02 1.060 0 0
Glycogen synthesis R-HSA-3322077 8.717867e-02 1.060 0 0
Signaling by ERBB4 R-HSA-1236394 8.738074e-02 1.059 0 0
Drug resistance of KIT mutants R-HSA-9669937 8.900269e-02 1.051 0 0
KIT mutants bind TKIs R-HSA-9669921 8.900269e-02 1.051 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 8.900269e-02 1.051 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 8.900269e-02 1.051 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 8.900269e-02 1.051 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 8.900269e-02 1.051 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 8.900269e-02 1.051 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 8.900269e-02 1.051 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 8.900269e-02 1.051 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 8.900269e-02 1.051 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 8.900269e-02 1.051 0 0
Hemostasis R-HSA-109582 8.942307e-02 1.049 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 8.979169e-02 1.047 0 0
Degradation of CDH1 R-HSA-9766229 9.009028e-02 1.045 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.156550e-02 1.038 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 9.156550e-02 1.038 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.156550e-02 1.038 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.192556e-02 1.037 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.267308e-02 1.033 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.267308e-02 1.033 0 0
PIP3 activates AKT signaling R-HSA-1257604 9.491079e-02 1.023 0 0
Signaling by Hedgehog R-HSA-5358351 9.523812e-02 1.021 0 0
IRE1alpha activates chaperones R-HSA-381070 9.599465e-02 1.018 0 0
MHC class II antigen presentation R-HSA-2132295 9.642173e-02 1.016 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 9.738174e-02 1.012 0 0
G-protein mediated events R-HSA-112040 9.738174e-02 1.012 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.748238e-02 1.011 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.867942e-02 1.006 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.867942e-02 1.006 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.867942e-02 1.006 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.867942e-02 1.006 0 0
Generic Transcription Pathway R-HSA-212436 9.919943e-02 1.003 0 0
Interferon Signaling R-HSA-913531 1.004040e-01 0.998 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.017139e-01 0.993 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.017139e-01 0.993 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.017139e-01 0.993 0 0
Regulation of Apoptosis R-HSA-169911 1.017275e-01 0.993 0 0
Signalling to ERKs R-HSA-187687 1.017275e-01 0.993 0 0
Oncogene Induced Senescence R-HSA-2559585 1.017275e-01 0.993 0 0
Gap junction degradation R-HSA-190873 1.032803e-01 0.986 0 0
p75NTR regulates axonogenesis R-HSA-193697 1.032803e-01 0.986 0 0
Unwinding of DNA R-HSA-176974 1.032803e-01 0.986 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.039857e-01 0.983 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.039857e-01 0.983 0 0
Translesion synthesis by REV1 R-HSA-110312 1.039857e-01 0.983 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.086556e-01 0.964 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.086556e-01 0.964 0 0
HCN channels R-HSA-1296061 1.086556e-01 0.964 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.086556e-01 0.964 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.086556e-01 0.964 0 0
FLT3 signaling in disease R-HSA-9682385 1.112446e-01 0.954 0 0
Glucose metabolism R-HSA-70326 1.122402e-01 0.950 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.124256e-01 0.949 0 0
Signaling by TGFB family members R-HSA-9006936 1.155490e-01 0.937 0 0
PLC beta mediated events R-HSA-112043 1.163680e-01 0.934 0 0
Vesicle-mediated transport R-HSA-5653656 1.174139e-01 0.930 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.183089e-01 0.927 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.191307e-01 0.924 0 0
Translesion synthesis by POLI R-HSA-5656121 1.191307e-01 0.924 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.191307e-01 0.924 0 0
Regulation of BACH1 activity R-HSA-9708530 1.191307e-01 0.924 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.212148e-01 0.916 0 0
Degradation of DVL R-HSA-4641258 1.212148e-01 0.916 0 0
Platelet degranulation R-HSA-114608 1.220050e-01 0.914 0 0
PI3K/AKT activation R-HSA-198203 1.230039e-01 0.910 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.230039e-01 0.910 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.230039e-01 0.910 0 0
2-LTR circle formation R-HSA-164843 1.230039e-01 0.910 0 0
Signaling by Leptin R-HSA-2586552 1.230039e-01 0.910 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.240621e-01 0.906 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.242930e-01 0.906 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.255457e-01 0.901 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.258071e-01 0.900 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.258071e-01 0.900 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.265138e-01 0.898 0 0
PKR-mediated signaling R-HSA-9833482 1.265138e-01 0.898 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.268608e-01 0.897 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.304100e-01 0.885 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.700887e-01 0.769 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.700887e-01 0.769 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.700887e-01 0.769 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 1.700887e-01 0.769 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.700887e-01 0.769 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 1.700887e-01 0.769 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.439618e-01 0.613 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.439618e-01 0.613 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.439618e-01 0.613 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.439618e-01 0.613 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.439618e-01 0.613 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.439618e-01 0.613 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.439618e-01 0.613 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.439618e-01 0.613 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.439618e-01 0.613 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.439618e-01 0.613 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.439618e-01 0.613 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.439618e-01 0.613 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.439618e-01 0.613 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.439618e-01 0.613 0 0
IRS activation R-HSA-74713 1.394433e-01 0.856 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.394433e-01 0.856 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.052418e-01 0.688 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.052418e-01 0.688 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.659965e-01 0.780 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.392832e-01 0.621 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.392832e-01 0.621 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.392832e-01 0.621 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.392832e-01 0.621 0 0
SOS-mediated signalling R-HSA-112412 2.392832e-01 0.621 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.392832e-01 0.621 0 0
Disorders of Developmental Biology R-HSA-9675151 1.351632e-01 0.869 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.351632e-01 0.869 0 0
Translesion synthesis by POLK R-HSA-5655862 1.351632e-01 0.869 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.351632e-01 0.869 0 0
Repression of WNT target genes R-HSA-4641265 1.889340e-01 0.724 0 0
Pervasive developmental disorders R-HSA-9005895 1.889340e-01 0.724 0 0
Disorders of Nervous System Development R-HSA-9697154 1.889340e-01 0.724 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.889340e-01 0.724 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.126160e-01 0.672 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 1.696110e-01 0.771 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.975033e-01 0.704 0 0
Dual Incision in GG-NER R-HSA-5696400 1.874380e-01 0.727 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.874380e-01 0.727 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.304460e-01 0.637 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.897817e-01 0.722 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.424878e-01 0.615 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.563414e-01 0.591 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.563414e-01 0.591 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.510150e-01 0.600 0 0
Neutrophil degranulation R-HSA-6798695 2.228665e-01 0.652 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 1.607469e-01 0.794 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.572470e-01 0.803 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.368872e-01 0.625 0 0
DNA Damage Bypass R-HSA-73893 1.677019e-01 0.775 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 2.457850e-01 0.609 0 0
G-protein activation R-HSA-202040 2.261101e-01 0.646 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.773957e-01 0.751 0 0
RET signaling R-HSA-8853659 2.159345e-01 0.666 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.394433e-01 0.856 0 0
Cellular response to hypoxia R-HSA-1234174 2.454561e-01 0.610 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.989508e-01 0.701 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.304460e-01 0.637 0 0
Signal transduction by L1 R-HSA-445144 2.067366e-01 0.685 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.584805e-01 0.800 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.210453e-01 0.656 0 0
PTEN Regulation R-HSA-6807070 1.485787e-01 0.828 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.653684e-01 0.782 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.015012e-01 0.696 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.015012e-01 0.696 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.304460e-01 0.637 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.515850e-01 0.819 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.605416e-01 0.794 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.889340e-01 0.724 0 0
Mitophagy R-HSA-5205647 1.874380e-01 0.727 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.718137e-01 0.765 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 1.878776e-01 0.726 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.773957e-01 0.751 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.457850e-01 0.609 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 1.394433e-01 0.856 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 1.515850e-01 0.819 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.424664e-01 0.846 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.015012e-01 0.696 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.288817e-01 0.640 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.605416e-01 0.794 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.880684e-01 0.726 0 0
Hedgehog 'on' state R-HSA-5632684 2.077737e-01 0.682 0 0
Polo-like kinase mediated events R-HSA-156711 1.696110e-01 0.771 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.563414e-01 0.591 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.368389e-01 0.864 0 0
Signaling by TGFBR3 R-HSA-9839373 1.365412e-01 0.865 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.316265e-01 0.881 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.439618e-01 0.613 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.439618e-01 0.613 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.439618e-01 0.613 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.718137e-01 0.765 0 0
Presynaptic function of Kainate receptors R-HSA-500657 1.696110e-01 0.771 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.515850e-01 0.819 0 0
Intraflagellar transport R-HSA-5620924 1.569735e-01 0.804 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.159345e-01 0.666 0 0
Degradation of AXIN R-HSA-4641257 2.307064e-01 0.637 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.288817e-01 0.640 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.975266e-01 0.704 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.025059e-01 0.694 0 0
Neurexins and neuroligins R-HSA-6794361 2.017738e-01 0.695 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.537192e-01 0.813 0 0
Signaling by Interleukins R-HSA-449147 2.023417e-01 0.694 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.663646e-01 0.779 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.663646e-01 0.779 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.537192e-01 0.813 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.487917e-01 0.827 0 0
Suppression of apoptosis R-HSA-9635465 1.439647e-01 0.842 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.874380e-01 0.727 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.397306e-01 0.855 0 0
Co-stimulation by CD28 R-HSA-389356 1.569735e-01 0.804 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.897817e-01 0.722 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.925733e-01 0.715 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.999777e-01 0.699 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.392832e-01 0.621 0 0
Protein hydroxylation R-HSA-9629569 2.067366e-01 0.685 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.605416e-01 0.794 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.737751e-01 0.760 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.459203e-01 0.609 0 0
Glycogen metabolism R-HSA-8982491 1.537192e-01 0.813 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.654809e-01 0.781 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.508919e-01 0.601 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 2.474767e-01 0.606 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.424878e-01 0.615 0 0
Inflammasomes R-HSA-622312 2.137724e-01 0.670 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.605416e-01 0.794 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.439618e-01 0.613 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.696110e-01 0.771 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.354714e-01 0.868 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.261101e-01 0.646 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.737751e-01 0.760 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.288817e-01 0.640 0 0
Disease R-HSA-1643685 1.990223e-01 0.701 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.337589e-01 0.631 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.182557e-01 0.661 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.881446e-01 0.726 0 0
Ion homeostasis R-HSA-5578775 2.510150e-01 0.600 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.605416e-01 0.794 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.874380e-01 0.727 0 0
NRAGE signals death through JNK R-HSA-193648 2.510150e-01 0.600 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.639502e-01 0.785 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 1.718137e-01 0.765 0 0
Glucagon-type ligand receptors R-HSA-420092 2.304460e-01 0.637 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.515850e-01 0.819 0 0
Neurodegenerative Diseases R-HSA-8863678 1.515850e-01 0.819 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.365138e-01 0.626 0 0
Specification of primordial germ cells R-HSA-9827857 1.520143e-01 0.818 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.351632e-01 0.869 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.459203e-01 0.609 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.261101e-01 0.646 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.126160e-01 0.672 0 0
Stimuli-sensing channels R-HSA-2672351 2.355165e-01 0.628 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.510150e-01 0.600 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.611378e-01 0.583 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.125765e-01 0.672 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.616000e-01 0.582 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.616000e-01 0.582 0 0
Trafficking of AMPA receptors R-HSA-399719 2.648169e-01 0.577 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.657707e-01 0.575 0 0
FGFR2 alternative splicing R-HSA-6803529 2.660905e-01 0.575 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.663783e-01 0.575 0 0
GPER1 signaling R-HSA-9634597 2.704184e-01 0.568 0 0
Inositol phosphate metabolism R-HSA-1483249 2.722579e-01 0.565 0 0
Alpha-defensins R-HSA-1462054 2.735642e-01 0.563 0 0
Sodium/Proton exchangers R-HSA-425986 2.735642e-01 0.563 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.735642e-01 0.563 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.767318e-01 0.558 0 0
DNA strand elongation R-HSA-69190 2.824192e-01 0.549 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.824192e-01 0.549 0 0
G0 and Early G1 R-HSA-1538133 2.824192e-01 0.549 0 0
PCP/CE pathway R-HSA-4086400 2.850683e-01 0.545 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.865457e-01 0.543 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.865457e-01 0.543 0 0
Phosphorylation of the APC/C R-HSA-176412 2.866153e-01 0.543 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.866153e-01 0.543 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 2.866153e-01 0.543 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.866153e-01 0.543 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.866153e-01 0.543 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.901916e-01 0.537 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.925343e-01 0.534 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.925343e-01 0.534 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.925343e-01 0.534 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.925343e-01 0.534 0 0
Potassium Channels R-HSA-1296071 2.998510e-01 0.523 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.002367e-01 0.523 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.002367e-01 0.523 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.002367e-01 0.523 0 0
Nucleotide Excision Repair R-HSA-5696398 3.006127e-01 0.522 0 0
Ion channel transport R-HSA-983712 3.046366e-01 0.516 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.065657e-01 0.513 0 0
Lipophagy R-HSA-9613354 3.077728e-01 0.512 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.077728e-01 0.512 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.077728e-01 0.512 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.077728e-01 0.512 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.077728e-01 0.512 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.077728e-01 0.512 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.077728e-01 0.512 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.077728e-01 0.512 0 0
Interleukin-1 processing R-HSA-448706 3.077728e-01 0.512 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.077728e-01 0.512 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.077728e-01 0.512 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.077728e-01 0.512 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.077728e-01 0.512 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.085124e-01 0.511 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.085124e-01 0.511 0 0
Translation of Structural Proteins R-HSA-9683701 3.085124e-01 0.511 0 0
Signaling by FGFR2 R-HSA-5654738 3.085446e-01 0.511 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.112632e-01 0.507 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.112632e-01 0.507 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.112632e-01 0.507 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.112632e-01 0.507 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.112632e-01 0.507 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 3.112632e-01 0.507 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.112632e-01 0.507 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.112632e-01 0.507 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.112632e-01 0.507 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.112632e-01 0.507 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.112632e-01 0.507 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.112632e-01 0.507 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.112632e-01 0.507 0 0
Interleukin-33 signaling R-HSA-9014843 3.112632e-01 0.507 0 0
Signalling to ERK5 R-HSA-198765 3.112632e-01 0.507 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.112632e-01 0.507 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 3.118038e-01 0.506 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.137462e-01 0.503 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.137462e-01 0.503 0 0
Aquaporin-mediated transport R-HSA-445717 3.170980e-01 0.499 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.182233e-01 0.497 0 0
Miscellaneous transport and binding events R-HSA-5223345 3.182233e-01 0.497 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.246338e-01 0.489 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.277254e-01 0.484 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 3.280239e-01 0.484 0 0
G protein gated Potassium channels R-HSA-1296059 3.280239e-01 0.484 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 3.280239e-01 0.484 0 0
HDMs demethylate histones R-HSA-3214842 3.280239e-01 0.484 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.284730e-01 0.484 0 0
Developmental Cell Lineages R-HSA-9734767 3.290262e-01 0.483 0 0
eNOS activation R-HSA-203615 3.363339e-01 0.473 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.363339e-01 0.473 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.363339e-01 0.473 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.370459e-01 0.472 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.370459e-01 0.472 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.391699e-01 0.470 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.408664e-01 0.467 0 0
Signaling by FGFR4 R-HSA-5654743 3.408664e-01 0.467 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.416504e-01 0.466 0 0
Binding and entry of HIV virion R-HSA-173107 3.416504e-01 0.466 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.416504e-01 0.466 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.416504e-01 0.466 0 0
Regulation of CDH11 function R-HSA-9762292 3.416504e-01 0.466 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.416504e-01 0.466 0 0
Signal attenuation R-HSA-74749 3.416504e-01 0.466 0 0
Tandem pore domain potassium channels R-HSA-1296346 3.416504e-01 0.466 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.416504e-01 0.466 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.433013e-01 0.464 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.489104e-01 0.457 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.571789e-01 0.447 0 0
Ion transport by P-type ATPases R-HSA-936837 3.582593e-01 0.446 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.622322e-01 0.441 0 0
GAB1 signalosome R-HSA-180292 3.622322e-01 0.441 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.622322e-01 0.441 0 0
Platelet sensitization by LDL R-HSA-432142 3.622322e-01 0.441 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.658068e-01 0.437 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.698097e-01 0.432 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 3.698097e-01 0.432 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.706491e-01 0.431 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.725772e-01 0.429 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 3.725772e-01 0.429 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.725772e-01 0.429 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.725772e-01 0.429 0 0
FasL/ CD95L signaling R-HSA-75157 3.725772e-01 0.429 0 0
MET interacts with TNS proteins R-HSA-8875513 3.725772e-01 0.429 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.725772e-01 0.429 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.725772e-01 0.429 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 3.725772e-01 0.429 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 3.725772e-01 0.429 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.727544e-01 0.429 0 0
RNA Polymerase III Transcription R-HSA-74158 3.727544e-01 0.429 0 0
GPVI-mediated activation cascade R-HSA-114604 3.727544e-01 0.429 0 0
G1/S-Specific Transcription R-HSA-69205 3.727544e-01 0.429 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.735407e-01 0.428 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 3.735407e-01 0.428 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 3.735407e-01 0.428 0 0
Signaling by FGFR3 R-HSA-5654741 3.735407e-01 0.428 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.749851e-01 0.426 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.749851e-01 0.426 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.749851e-01 0.426 0 0
Interleukin-2 signaling R-HSA-9020558 3.749851e-01 0.426 0 0
Signaling by APC mutants R-HSA-4839744 3.749851e-01 0.426 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.749851e-01 0.426 0 0
Leishmania infection R-HSA-9658195 3.808745e-01 0.419 0 0
Parasitic Infection Pathways R-HSA-9824443 3.808745e-01 0.419 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.810960e-01 0.419 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.811712e-01 0.419 0 0
Signaling by NTRKs R-HSA-166520 3.816595e-01 0.418 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.871596e-01 0.412 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.872635e-01 0.412 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.872635e-01 0.412 0 0
Signaling by FGFR1 R-HSA-5654736 3.881602e-01 0.411 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.899221e-01 0.409 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 3.899221e-01 0.409 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 3.899221e-01 0.409 0 0
Diseases of DNA repair R-HSA-9675135 3.899221e-01 0.409 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.906624e-01 0.408 0 0
tRNA processing R-HSA-72306 4.017582e-01 0.396 0 0
Pyruvate metabolism R-HSA-70268 4.057721e-01 0.392 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.076052e-01 0.390 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.076052e-01 0.390 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.076052e-01 0.390 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.076052e-01 0.390 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.076052e-01 0.390 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.076052e-01 0.390 0 0
Signaling by AXIN mutants R-HSA-4839735 4.076052e-01 0.390 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.076052e-01 0.390 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.076052e-01 0.390 0 0
Circadian clock R-HSA-9909396 4.077923e-01 0.390 0 0
MET promotes cell motility R-HSA-8875878 4.091680e-01 0.388 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.094545e-01 0.388 0 0
DARPP-32 events R-HSA-180024 4.114130e-01 0.386 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.120506e-01 0.385 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.120506e-01 0.385 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.120506e-01 0.385 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.120506e-01 0.385 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.120506e-01 0.385 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.120506e-01 0.385 0 0
Formation of definitive endoderm R-HSA-9823730 4.120506e-01 0.385 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.120506e-01 0.385 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.120506e-01 0.385 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.120506e-01 0.385 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 4.138514e-01 0.383 0 0
Dual incision in TC-NER R-HSA-6782135 4.181498e-01 0.379 0 0
NGF-stimulated transcription R-HSA-9031628 4.226301e-01 0.374 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.272771e-01 0.369 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.272771e-01 0.369 0 0
Regulation of gap junction activity R-HSA-191650 4.284360e-01 0.368 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.284360e-01 0.368 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.284360e-01 0.368 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.284360e-01 0.368 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.284360e-01 0.368 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.284360e-01 0.368 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.284360e-01 0.368 0 0
Alanine metabolism R-HSA-8964540 4.284360e-01 0.368 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.284360e-01 0.368 0 0
NADE modulates death signalling R-HSA-205025 4.284360e-01 0.368 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.284360e-01 0.368 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.284360e-01 0.368 0 0
Dopamine receptors R-HSA-390651 4.284360e-01 0.368 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.320097e-01 0.365 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.320097e-01 0.365 0 0
Neuronal System R-HSA-112316 4.359162e-01 0.361 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.365140e-01 0.360 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.365140e-01 0.360 0 0
Signaling by FGFR R-HSA-190236 4.370565e-01 0.359 0 0
Leading Strand Synthesis R-HSA-69109 4.393738e-01 0.357 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.393738e-01 0.357 0 0
Polymerase switching R-HSA-69091 4.393738e-01 0.357 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.393738e-01 0.357 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.393738e-01 0.357 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.393738e-01 0.357 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.393738e-01 0.357 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.393738e-01 0.357 0 0
Interleukin-15 signaling R-HSA-8983432 4.393738e-01 0.357 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.393738e-01 0.357 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.393738e-01 0.357 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.393738e-01 0.357 0 0
Signaling by LTK R-HSA-9842663 4.393738e-01 0.357 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.416303e-01 0.355 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.452741e-01 0.351 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.452741e-01 0.351 0 0
Rab regulation of trafficking R-HSA-9007101 4.482301e-01 0.348 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.605835e-01 0.337 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.613574e-01 0.336 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.652083e-01 0.332 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.652083e-01 0.332 0 0
Immune System R-HSA-168256 4.656197e-01 0.332 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.701841e-01 0.328 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 4.701841e-01 0.328 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.701841e-01 0.328 0 0
Processing of SMDT1 R-HSA-8949664 4.701841e-01 0.328 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.701841e-01 0.328 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.701841e-01 0.328 0 0
Maturation of nucleoprotein R-HSA-9683610 4.701841e-01 0.328 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.701841e-01 0.328 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.711586e-01 0.327 0 0
Interleukin-1 signaling R-HSA-9020702 4.719998e-01 0.326 0 0
Inwardly rectifying K+ channels R-HSA-1296065 4.725555e-01 0.326 0 0
Activation of AMPA receptors R-HSA-399710 4.793249e-01 0.319 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.793249e-01 0.319 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 4.793249e-01 0.319 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.793249e-01 0.319 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.793249e-01 0.319 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.793249e-01 0.319 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 4.793249e-01 0.319 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.793249e-01 0.319 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 4.793249e-01 0.319 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.793249e-01 0.319 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.793249e-01 0.319 0 0
Reelin signalling pathway R-HSA-8866376 4.793249e-01 0.319 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.793249e-01 0.319 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.793249e-01 0.319 0 0
Interleukin-36 pathway R-HSA-9014826 4.793249e-01 0.319 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.793249e-01 0.319 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.793249e-01 0.319 0 0
Ca2+ pathway R-HSA-4086398 4.829059e-01 0.316 0 0
Notch-HLH transcription pathway R-HSA-350054 4.841980e-01 0.315 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.870955e-01 0.312 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.870955e-01 0.312 0 0
Parasite infection R-HSA-9664407 4.968090e-01 0.304 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.968090e-01 0.304 0 0
Leishmania phagocytosis R-HSA-9664417 4.968090e-01 0.304 0 0
Activation of GABAB receptors R-HSA-991365 4.982793e-01 0.303 0 0
GABA B receptor activation R-HSA-977444 4.982793e-01 0.303 0 0
Removal of the Flap Intermediate R-HSA-69166 4.999549e-01 0.301 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.999549e-01 0.301 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.999549e-01 0.301 0 0
Zinc transporters R-HSA-435354 4.999549e-01 0.301 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.028762e-01 0.299 0 0
Cardiac conduction R-HSA-5576891 5.040333e-01 0.298 0 0
Growth hormone receptor signaling R-HSA-982772 5.073046e-01 0.295 0 0
Cellular response to chemical stress R-HSA-9711123 5.143024e-01 0.289 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.256856e-01 0.279 0 0
Plus-strand DNA synthesis R-HSA-164525 5.256856e-01 0.279 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.256856e-01 0.279 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.256856e-01 0.279 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.256856e-01 0.279 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.256856e-01 0.279 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.256856e-01 0.279 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.256856e-01 0.279 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 5.256856e-01 0.279 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.256856e-01 0.279 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.256856e-01 0.279 0 0
TRAIL signaling R-HSA-75158 5.256856e-01 0.279 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.256856e-01 0.279 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.256856e-01 0.279 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.256856e-01 0.279 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.256856e-01 0.279 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.256856e-01 0.279 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.256856e-01 0.279 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.256856e-01 0.279 0 0
Erythropoietin activates RAS R-HSA-9027284 5.286272e-01 0.277 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.286272e-01 0.277 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.286272e-01 0.277 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.286272e-01 0.277 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.286272e-01 0.277 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.286272e-01 0.277 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.286272e-01 0.277 0 0
Protein methylation R-HSA-8876725 5.286272e-01 0.277 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.298586e-01 0.276 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.298586e-01 0.276 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.309388e-01 0.275 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.311599e-01 0.275 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.311599e-01 0.275 0 0
G alpha (z) signalling events R-HSA-418597 5.338909e-01 0.273 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.391869e-01 0.268 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.518223e-01 0.258 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.518223e-01 0.258 0 0
Tight junction interactions R-HSA-420029 5.518223e-01 0.258 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.561605e-01 0.255 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.561605e-01 0.255 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.561605e-01 0.255 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.561605e-01 0.255 0 0
ER-Phagosome pathway R-HSA-1236974 5.624224e-01 0.250 0 0
Regulation of insulin secretion R-HSA-422356 5.624251e-01 0.250 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.624251e-01 0.250 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.624251e-01 0.250 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.624251e-01 0.250 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.625792e-01 0.250 0 0
Sensory processing of sound R-HSA-9659379 5.626278e-01 0.250 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.679209e-01 0.246 0 0
Signaling by LTK in cancer R-HSA-9842640 5.679209e-01 0.246 0 0
STAT5 Activation R-HSA-9645135 5.679209e-01 0.246 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.679209e-01 0.246 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.679209e-01 0.246 0 0
Uncoating of the HIV Virion R-HSA-162585 5.679209e-01 0.246 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.679209e-01 0.246 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.679209e-01 0.246 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 5.679209e-01 0.246 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.679209e-01 0.246 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.679209e-01 0.246 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.679209e-01 0.246 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.679209e-01 0.246 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 5.679209e-01 0.246 0 0
HDL clearance R-HSA-8964011 5.679209e-01 0.246 0 0
Neurofascin interactions R-HSA-447043 5.679209e-01 0.246 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.731652e-01 0.242 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.731652e-01 0.242 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.734393e-01 0.242 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.734901e-01 0.241 0 0
Passive transport by Aquaporins R-HSA-432047 5.825304e-01 0.235 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.825304e-01 0.235 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.825304e-01 0.235 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.827141e-01 0.235 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.836425e-01 0.234 0 0
Voltage gated Potassium channels R-HSA-1296072 5.863617e-01 0.232 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.938630e-01 0.226 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 5.938630e-01 0.226 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.938630e-01 0.226 0 0
Metal ion SLC transporters R-HSA-425410 5.975638e-01 0.224 0 0
Potential therapeutics for SARS R-HSA-9679191 6.010132e-01 0.221 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.063976e-01 0.217 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.063976e-01 0.217 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.063976e-01 0.217 0 0
PTK6 Expression R-HSA-8849473 6.063976e-01 0.217 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.063976e-01 0.217 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.063976e-01 0.217 0 0
VLDL clearance R-HSA-8964046 6.063976e-01 0.217 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.063976e-01 0.217 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.063976e-01 0.217 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.077258e-01 0.216 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.077258e-01 0.216 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.077258e-01 0.216 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.077258e-01 0.216 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.077258e-01 0.216 0 0
Choline catabolism R-HSA-6798163 6.077258e-01 0.216 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.130106e-01 0.213 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.159258e-01 0.210 0 0
Signaling by ALK R-HSA-201556 6.209760e-01 0.207 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.209760e-01 0.207 0 0
RAS processing R-HSA-9648002 6.209760e-01 0.207 0 0
MAP kinase activation R-HSA-450294 6.214007e-01 0.207 0 0
PKA activation R-HSA-163615 6.317467e-01 0.199 0 0
Mismatch Repair R-HSA-5358508 6.317467e-01 0.199 0 0
PKA activation in glucagon signalling R-HSA-164378 6.317467e-01 0.199 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.317467e-01 0.199 0 0
Apoptotic factor-mediated response R-HSA-111471 6.317467e-01 0.199 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.317467e-01 0.199 0 0
Signaling by Erythropoietin R-HSA-9006335 6.332537e-01 0.198 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.332537e-01 0.198 0 0
Heme signaling R-HSA-9707616 6.350446e-01 0.197 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.375817e-01 0.195 0 0
Diseases of Immune System R-HSA-5260271 6.375817e-01 0.195 0 0
RSV-host interactions R-HSA-9833110 6.395505e-01 0.194 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.414500e-01 0.193 0 0
Minus-strand DNA synthesis R-HSA-164516 6.414500e-01 0.193 0 0
Regulation by c-FLIP R-HSA-3371378 6.414500e-01 0.193 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.414500e-01 0.193 0 0
DAG1 core M2 glycosylations R-HSA-8932504 6.414500e-01 0.193 0 0
phospho-PLA2 pathway R-HSA-111995 6.414500e-01 0.193 0 0
Dimerization of procaspase-8 R-HSA-69416 6.414500e-01 0.193 0 0
MET receptor recycling R-HSA-8875656 6.414500e-01 0.193 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.414500e-01 0.193 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.414500e-01 0.193 0 0
Interleukin-9 signaling R-HSA-8985947 6.414500e-01 0.193 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.414500e-01 0.193 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.414500e-01 0.193 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.414500e-01 0.193 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.414500e-01 0.193 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.414500e-01 0.193 0 0
Signaling by FGFR in disease R-HSA-1226099 6.417249e-01 0.193 0 0
SLC transporter disorders R-HSA-5619102 6.515003e-01 0.186 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.519246e-01 0.186 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.519246e-01 0.186 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.519246e-01 0.186 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.519246e-01 0.186 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.519246e-01 0.186 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 6.519246e-01 0.186 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 6.537064e-01 0.185 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.539967e-01 0.184 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.546024e-01 0.184 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.546024e-01 0.184 0 0
Maturation of nucleoprotein R-HSA-9694631 6.546024e-01 0.184 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.693431e-01 0.174 0 0
Downstream signal transduction R-HSA-186763 6.699053e-01 0.174 0 0
Toll-like Receptor Cascades R-HSA-168898 6.710170e-01 0.173 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.711874e-01 0.173 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 6.733828e-01 0.172 0 0
Interleukin-21 signaling R-HSA-9020958 6.733828e-01 0.172 0 0
CASP8 activity is inhibited R-HSA-5218900 6.733828e-01 0.172 0 0
ALK mutants bind TKIs R-HSA-9700645 6.733828e-01 0.172 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.733828e-01 0.172 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.733828e-01 0.172 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.733828e-01 0.172 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.733828e-01 0.172 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.733828e-01 0.172 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.733828e-01 0.172 0 0
Calcineurin activates NFAT R-HSA-2025928 6.733828e-01 0.172 0 0
WNT mediated activation of DVL R-HSA-201688 6.733828e-01 0.172 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 6.733828e-01 0.172 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.763099e-01 0.170 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.763099e-01 0.170 0 0
Signaling by NODAL R-HSA-1181150 6.763099e-01 0.170 0 0
Translation of Structural Proteins R-HSA-9694635 6.777717e-01 0.169 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.801331e-01 0.167 0 0
Signaling by WNT in cancer R-HSA-4791275 6.871953e-01 0.163 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.939685e-01 0.159 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.939685e-01 0.159 0 0
FOXO-mediated transcription R-HSA-9614085 6.958002e-01 0.158 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.968925e-01 0.157 0 0
Lagging Strand Synthesis R-HSA-69186 6.968925e-01 0.157 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.968925e-01 0.157 0 0
Basigin interactions R-HSA-210991 6.968925e-01 0.157 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.980763e-01 0.156 0 0
Signaling by SCF-KIT R-HSA-1433557 6.991359e-01 0.155 0 0
DNA replication initiation R-HSA-68952 7.024733e-01 0.153 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.024733e-01 0.153 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.024733e-01 0.153 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.024733e-01 0.153 0 0
Interleukin-27 signaling R-HSA-9020956 7.024733e-01 0.153 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.024733e-01 0.153 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.024733e-01 0.153 0 0
Sperm Motility And Taxes R-HSA-1300642 7.024733e-01 0.153 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.024733e-01 0.153 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.024733e-01 0.153 0 0
Downstream TCR signaling R-HSA-202424 7.028882e-01 0.153 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.037973e-01 0.153 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.037973e-01 0.153 0 0
Proteasome assembly R-HSA-9907900 7.132889e-01 0.147 0 0
Amine ligand-binding receptors R-HSA-375280 7.132889e-01 0.147 0 0
G1 Phase R-HSA-69236 7.132889e-01 0.147 0 0
Cyclin D associated events in G1 R-HSA-69231 7.132889e-01 0.147 0 0
Interleukin-1 family signaling R-HSA-446652 7.140499e-01 0.146 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.163782e-01 0.145 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.163782e-01 0.145 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.163782e-01 0.145 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.197171e-01 0.143 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.197171e-01 0.143 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.205900e-01 0.142 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.205900e-01 0.142 0 0
Somitogenesis R-HSA-9824272 7.269474e-01 0.138 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.289744e-01 0.137 0 0
DAG1 core M3 glycosylations R-HSA-8932505 7.289744e-01 0.137 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 7.289744e-01 0.137 0 0
LGI-ADAM interactions R-HSA-5682910 7.289744e-01 0.137 0 0
vRNP Assembly R-HSA-192905 7.289744e-01 0.137 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.289744e-01 0.137 0 0
Bicarbonate transporters R-HSA-425381 7.289744e-01 0.137 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.289744e-01 0.137 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.289744e-01 0.137 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.289744e-01 0.137 0 0
Prostanoid ligand receptors R-HSA-391908 7.289744e-01 0.137 0 0
Transport of RCbl within the body R-HSA-9758890 7.289744e-01 0.137 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.289744e-01 0.137 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.291248e-01 0.137 0 0
Interleukin-17 signaling R-HSA-448424 7.331557e-01 0.135 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.347992e-01 0.134 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.347992e-01 0.134 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 7.349630e-01 0.134 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.349630e-01 0.134 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 7.401142e-01 0.131 0 0
Extension of Telomeres R-HSA-180786 7.470046e-01 0.127 0 0
Peroxisomal protein import R-HSA-9033241 7.470046e-01 0.127 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.477459e-01 0.126 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.495458e-01 0.125 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.518112e-01 0.124 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.521905e-01 0.124 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.521905e-01 0.124 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.521905e-01 0.124 0 0
Syndecan interactions R-HSA-3000170 7.521905e-01 0.124 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.531164e-01 0.123 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.531164e-01 0.123 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.531164e-01 0.123 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.531164e-01 0.123 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 7.531164e-01 0.123 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.531164e-01 0.123 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.545049e-01 0.122 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.545049e-01 0.122 0 0
GABA receptor activation R-HSA-977443 7.582856e-01 0.120 0 0
Triglyceride catabolism R-HSA-163560 7.634780e-01 0.117 0 0
Gluconeogenesis R-HSA-70263 7.649915e-01 0.116 0 0
Platelet homeostasis R-HSA-418346 7.689116e-01 0.114 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.738808e-01 0.111 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.745792e-01 0.111 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.751092e-01 0.111 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.751092e-01 0.111 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.751092e-01 0.111 0 0
Interleukin-35 Signalling R-HSA-8984722 7.751092e-01 0.111 0 0
Regulation of IFNG signaling R-HSA-877312 7.751092e-01 0.111 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.751092e-01 0.111 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.751092e-01 0.111 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.751092e-01 0.111 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.751092e-01 0.111 0 0
OAS antiviral response R-HSA-8983711 7.751092e-01 0.111 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.797050e-01 0.108 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.805143e-01 0.108 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.840344e-01 0.106 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.840344e-01 0.106 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.840344e-01 0.106 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.840344e-01 0.106 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.840344e-01 0.106 0 0
Iron uptake and transport R-HSA-917937 7.841436e-01 0.106 0 0
Transmission across Chemical Synapses R-HSA-112315 7.850675e-01 0.105 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.894486e-01 0.103 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 7.951441e-01 0.100 0 0
Interleukin-6 signaling R-HSA-1059683 7.951441e-01 0.100 0 0
Formation of axial mesoderm R-HSA-9796292 7.951441e-01 0.100 0 0
FGFR1c ligand binding and activation R-HSA-190373 7.951441e-01 0.100 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 7.951441e-01 0.100 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.951441e-01 0.100 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.985655e-01 0.098 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.985655e-01 0.098 0 0
Myogenesis R-HSA-525793 7.985655e-01 0.098 0 0
The phototransduction cascade R-HSA-2514856 7.987678e-01 0.098 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.007944e-01 0.096 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.015195e-01 0.096 0 0
Adipogenesis R-HSA-9843745 8.049558e-01 0.094 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.091165e-01 0.092 0 0
ABC-family proteins mediated transport R-HSA-382556 8.103264e-01 0.091 0 0
ABC transporter disorders R-HSA-5619084 8.109847e-01 0.091 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.122229e-01 0.090 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.122229e-01 0.090 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.122229e-01 0.090 0 0
Cristae formation R-HSA-8949613 8.122229e-01 0.090 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.122229e-01 0.090 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.122229e-01 0.090 0 0
Interleukin-2 family signaling R-HSA-451927 8.130038e-01 0.090 0 0
Regulation of KIT signaling R-HSA-1433559 8.133952e-01 0.090 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.133952e-01 0.090 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.133952e-01 0.090 0 0
Hydrolysis of LPC R-HSA-1483115 8.133952e-01 0.090 0 0
Prolactin receptor signaling R-HSA-1170546 8.133952e-01 0.090 0 0
Malate-aspartate shuttle R-HSA-9856872 8.133952e-01 0.090 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.133952e-01 0.090 0 0
Signal regulatory protein family interactions R-HSA-391160 8.133952e-01 0.090 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.133952e-01 0.090 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 8.140467e-01 0.089 0 0
Nucleotide biosynthesis R-HSA-8956320 8.190267e-01 0.087 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.239200e-01 0.084 0 0
Telomere Extension By Telomerase R-HSA-171319 8.250468e-01 0.084 0 0
HIV elongation arrest and recovery R-HSA-167287 8.250468e-01 0.084 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.250468e-01 0.084 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.250468e-01 0.084 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.250468e-01 0.084 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.300213e-01 0.081 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.300213e-01 0.081 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.300213e-01 0.081 0 0
Protein lipoylation R-HSA-9857492 8.300213e-01 0.081 0 0
Signaling by Activin R-HSA-1502540 8.300213e-01 0.081 0 0
p38MAPK events R-HSA-171007 8.300213e-01 0.081 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.342868e-01 0.079 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.364846e-01 0.078 0 0
mRNA Capping R-HSA-72086 8.370773e-01 0.077 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.370773e-01 0.077 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.370773e-01 0.077 0 0
Integration of energy metabolism R-HSA-163685 8.422583e-01 0.075 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.432245e-01 0.074 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.451669e-01 0.073 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.451669e-01 0.073 0 0
Atorvastatin ADME R-HSA-9754706 8.451669e-01 0.073 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.451669e-01 0.073 0 0
Activation of SMO R-HSA-5635838 8.451669e-01 0.073 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.462353e-01 0.073 0 0
Interferon alpha/beta signaling R-HSA-909733 8.476155e-01 0.072 0 0
DAP12 signaling R-HSA-2424491 8.483540e-01 0.071 0 0
Interleukin-37 signaling R-HSA-9008059 8.483540e-01 0.071 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.498157e-01 0.071 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.498157e-01 0.071 0 0
Neddylation R-HSA-8951664 8.557810e-01 0.068 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.565567e-01 0.067 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.589156e-01 0.066 0 0
Glycine degradation R-HSA-6783984 8.589638e-01 0.066 0 0
Phase 2 - plateau phase R-HSA-5576893 8.589638e-01 0.066 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.589638e-01 0.066 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.589638e-01 0.066 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.589638e-01 0.066 0 0
Coenzyme A biosynthesis R-HSA-196783 8.589638e-01 0.066 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.589638e-01 0.066 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.589638e-01 0.066 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.589638e-01 0.066 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 8.622847e-01 0.064 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.688000e-01 0.061 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.688000e-01 0.061 0 0
Regulation of beta-cell development R-HSA-186712 8.699070e-01 0.061 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.699070e-01 0.061 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.715321e-01 0.060 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.715321e-01 0.060 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.715321e-01 0.060 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.715321e-01 0.060 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.715321e-01 0.060 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.715321e-01 0.060 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.721933e-01 0.059 0 0
Nuclear RNA decay R-HSA-9930044 8.780440e-01 0.056 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 8.806541e-01 0.055 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.829810e-01 0.054 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.829810e-01 0.054 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.829810e-01 0.054 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.829810e-01 0.054 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.829810e-01 0.054 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.829810e-01 0.054 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.838856e-01 0.054 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.838856e-01 0.054 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.866831e-01 0.052 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.866831e-01 0.052 0 0
Heme degradation R-HSA-189483 8.866831e-01 0.052 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.866831e-01 0.052 0 0
Mitochondrial protein import R-HSA-1268020 8.903711e-01 0.050 0 0
Signaling by PDGF R-HSA-186797 8.903711e-01 0.050 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.934102e-01 0.049 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.934102e-01 0.049 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.934102e-01 0.049 0 0
Diseases of hemostasis R-HSA-9671793 8.934102e-01 0.049 0 0
Specification of the neural plate border R-HSA-9834899 8.934102e-01 0.049 0 0
Other interleukin signaling R-HSA-449836 8.934102e-01 0.049 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.947518e-01 0.048 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.965372e-01 0.047 0 0
Interferon gamma signaling R-HSA-877300 8.971468e-01 0.047 0 0
PI Metabolism R-HSA-1483255 9.008521e-01 0.045 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.019050e-01 0.045 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.022830e-01 0.045 0 0
PERK regulates gene expression R-HSA-381042 9.022830e-01 0.045 0 0
IGF1R signaling cascade R-HSA-2428924 9.023960e-01 0.045 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.029105e-01 0.044 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.029105e-01 0.044 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.029105e-01 0.044 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.029105e-01 0.044 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.058103e-01 0.043 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.058103e-01 0.043 0 0
Azathioprine ADME R-HSA-9748787 9.060602e-01 0.043 0 0
PI3K Cascade R-HSA-109704 9.060602e-01 0.043 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.079595e-01 0.042 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.093085e-01 0.041 0 0
RUNX2 regulates bone development R-HSA-8941326 9.093085e-01 0.041 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.115645e-01 0.040 0 0
Signalling to RAS R-HSA-167044 9.115645e-01 0.040 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.115645e-01 0.040 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.115645e-01 0.040 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.115645e-01 0.040 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.125283e-01 0.040 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.132397e-01 0.039 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.166868e-01 0.038 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.178223e-01 0.037 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.194477e-01 0.036 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.194477e-01 0.036 0 0
Ribavirin ADME R-HSA-9755088 9.194477e-01 0.036 0 0
Mitochondrial biogenesis R-HSA-1592230 9.201571e-01 0.036 0 0
Protein localization R-HSA-9609507 9.216132e-01 0.035 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.219620e-01 0.035 0 0
Signaling by KIT in disease R-HSA-9669938 9.266285e-01 0.033 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.266285e-01 0.033 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.266285e-01 0.033 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.266285e-01 0.033 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.266285e-01 0.033 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.266285e-01 0.033 0 0
LDL clearance R-HSA-8964038 9.266285e-01 0.033 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.266285e-01 0.033 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.276465e-01 0.033 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.325474e-01 0.030 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.329381e-01 0.030 0 0
HIV Transcription Elongation R-HSA-167169 9.329381e-01 0.030 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.329381e-01 0.030 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.331696e-01 0.030 0 0
Interleukin-20 family signaling R-HSA-8854691 9.331696e-01 0.030 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.331696e-01 0.030 0 0
Carnitine shuttle R-HSA-200425 9.331696e-01 0.030 0 0
Biosynthesis of maresins R-HSA-9018682 9.331696e-01 0.030 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.364373e-01 0.029 0 0
G alpha (s) signalling events R-HSA-418555 9.386844e-01 0.027 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.391280e-01 0.027 0 0
Interleukin-6 family signaling R-HSA-6783589 9.391280e-01 0.027 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.391280e-01 0.027 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.391280e-01 0.027 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.404731e-01 0.027 0 0
Dectin-2 family R-HSA-5621480 9.409557e-01 0.026 0 0
IRS-mediated signalling R-HSA-112399 9.409557e-01 0.026 0 0
Synthesis of PA R-HSA-1483166 9.409557e-01 0.026 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.424409e-01 0.026 0 0
Intra-Golgi traffic R-HSA-6811438 9.424409e-01 0.026 0 0
Formation of the cornified envelope R-HSA-6809371 9.427549e-01 0.026 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.445554e-01 0.025 0 0
Hyaluronan degradation R-HSA-2160916 9.445554e-01 0.025 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.445554e-01 0.025 0 0
Fertilization R-HSA-1187000 9.445554e-01 0.025 0 0
Laminin interactions R-HSA-3000157 9.445554e-01 0.025 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.448231e-01 0.025 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.466978e-01 0.024 0 0
Triglyceride metabolism R-HSA-8979227 9.484540e-01 0.023 0 0
MET activates PTK2 signaling R-HSA-8874081 9.494992e-01 0.023 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.494992e-01 0.023 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.494992e-01 0.023 0 0
TRP channels R-HSA-3295583 9.494992e-01 0.023 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.494992e-01 0.023 0 0
Urea cycle R-HSA-70635 9.494992e-01 0.023 0 0
Sphingolipid catabolism R-HSA-9845614 9.494992e-01 0.023 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.494992e-01 0.023 0 0
Defensins R-HSA-1461973 9.506536e-01 0.022 0 0
TBC/RABGAPs R-HSA-8854214 9.506536e-01 0.022 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.516410e-01 0.022 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.518614e-01 0.021 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.518614e-01 0.021 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.540024e-01 0.020 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.540024e-01 0.020 0 0
Insulin processing R-HSA-264876 9.540024e-01 0.020 0 0
DAP12 interactions R-HSA-2172127 9.543281e-01 0.020 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 9.577399e-01 0.019 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.580541e-01 0.019 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.581044e-01 0.019 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.581044e-01 0.019 0 0
Prednisone ADME R-HSA-9757110 9.581044e-01 0.019 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.610175e-01 0.017 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.618407e-01 0.017 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.618407e-01 0.017 0 0
Platelet calcium homeostasis R-HSA-418360 9.618407e-01 0.017 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.618407e-01 0.017 0 0
Insulin receptor signalling cascade R-HSA-74751 9.634935e-01 0.016 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.638451e-01 0.016 0 0
Collagen formation R-HSA-1474290 9.648164e-01 0.016 0 0
Neurotransmitter clearance R-HSA-112311 9.652441e-01 0.015 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.690976e-01 0.014 0 0
DAG1 glycosylations R-HSA-8931838 9.711677e-01 0.013 0 0
Transcription of the HIV genome R-HSA-167172 9.724404e-01 0.012 0 0
Gastrulation R-HSA-9758941 9.727968e-01 0.012 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.736626e-01 0.012 0 0
Cardiogenesis R-HSA-9733709 9.737396e-01 0.012 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.760823e-01 0.011 0 0
Post-translational protein modification R-HSA-597592 9.763738e-01 0.010 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.774837e-01 0.010 0 0
Metabolism of cofactors R-HSA-8978934 9.777409e-01 0.010 0 0
Hyaluronan metabolism R-HSA-2142845 9.782161e-01 0.010 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.801596e-01 0.009 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.801596e-01 0.009 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.819299e-01 0.008 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.819299e-01 0.008 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.820615e-01 0.008 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.834106e-01 0.007 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.835423e-01 0.007 0 0
NCAM1 interactions R-HSA-419037 9.835423e-01 0.007 0 0
Lysine catabolism R-HSA-71064 9.835423e-01 0.007 0 0
Collagen chain trimerization R-HSA-8948216 9.835423e-01 0.007 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.855732e-01 0.006 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.863485e-01 0.006 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.863485e-01 0.006 0 0
Integrin cell surface interactions R-HSA-216083 9.865896e-01 0.006 0 0
Innate Immune System R-HSA-168249 9.870078e-01 0.006 0 0
tRNA Aminoacylation R-HSA-379724 9.871586e-01 0.006 0 0
Metabolism of polyamines R-HSA-351202 9.871586e-01 0.006 0 0
Mitochondrial protein degradation R-HSA-9837999 9.872858e-01 0.006 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.875669e-01 0.005 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.875669e-01 0.005 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.886765e-01 0.005 0 0
Maturation of spike protein R-HSA-9694548 9.886765e-01 0.005 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.893402e-01 0.005 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.896872e-01 0.005 0 0
HIV Transcription Initiation R-HSA-167161 9.896872e-01 0.005 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.896872e-01 0.005 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.896872e-01 0.005 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.904502e-01 0.004 0 0
Metabolism of proteins R-HSA-392499 9.905367e-01 0.004 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.906078e-01 0.004 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.909734e-01 0.004 0 0
PPARA activates gene expression R-HSA-1989781 9.909998e-01 0.004 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.914462e-01 0.004 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.919679e-01 0.004 0 0
Surfactant metabolism R-HSA-5683826 9.922098e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.922098e-01 0.003 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.929053e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.933081e-01 0.003 0 0
Synthesis of PC R-HSA-1483191 9.941157e-01 0.003 0 0
Metabolism of porphyrins R-HSA-189445 9.947717e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.951196e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.951858e-01 0.002 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.955555e-01 0.002 0 0
Signaling by Insulin receptor R-HSA-74752 9.959416e-01 0.002 0 0
FCGR activation R-HSA-2029481 9.962393e-01 0.002 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.962393e-01 0.002 0 0
Extracellular matrix organization R-HSA-1474244 9.965679e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.966297e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.970735e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.972071e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.972161e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.972314e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.974725e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.978133e-01 0.001 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.978976e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.980854e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.984123e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.986834e-01 0.001 0 0
Xenobiotics R-HSA-211981 9.988011e-01 0.001 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.990391e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.990947e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.993165e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.993165e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.993776e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.993776e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.994742e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.994839e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.995056e-01 0.000 0 0
Keratinization R-HSA-6805567 9.996479e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.996620e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.996770e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.996770e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.997059e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.997561e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.998416e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998529e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.998848e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998930e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.999045e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999142e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999208e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999213e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999370e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999549e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999621e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999626e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999645e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999766e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999784e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999793e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999806e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999879e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999898e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999912e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999928e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999969e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999971e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999973e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999973e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999975e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999979e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999989e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999991e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999995e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999995e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999997e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999997e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999998e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways