CDK3

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0MZ66 S444 Sugiyama SHTN1 KIAA1598 RPVNQTARPKTKPESSKGCEsAVDELKGILGtLNKSTSSRs
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00115 S70 Sugiyama DNASE2 DNASE2A DNL2 QYKyLDEssGGWRDGRALINsPEGAVGRSLQPLyRSNTSQL
O00429 S126 Sugiyama DNM1L DLP1 DRP1 EIRQEIENETERISGNNKGVsPEPIHLKIFSPNVVNLTLVD
O43237 S194 Sugiyama DYNC1LI2 DNCLI2 LIC2 ERKFVKDFQDyMEPEEGCQGsPQRRGPLtsGsDEENVALPL
O43765 S77 Sugiyama SGTA SGT SGT1 TLPEIFEAAATGKEMPQDLRsPARtPPsEEDsAEAERLKTE
O43765 T81 Sugiyama SGTA SGT SGT1 IFEAAATGKEMPQDLRsPARtPPsEEDsAEAERLKTEGNEQ
O43852 T65 Sugiyama CALU FDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKD
O60361 S105 Sugiyama NME2P1 KPGtIRGDFCIQVGRNIIHGsDsVKsAEKEISLRFKPEELV
O60361 S107 Sugiyama NME2P1 GtIRGDFCIQVGRNIIHGsDsVKsAEKEISLRFKPEELVDY
O60361 S110 Sugiyama NME2P1 RGDFCIQVGRNIIHGsDsVKsAEKEISLRFKPEELVDYKSC
O60701 T185 Sugiyama UGDH EGTAIKDLKNPDRVLIGGDEtPEGQRAVQALCAVYEHWVPR
O75179 S2042 Sugiyama ANKRD17 GTAR KIAA0697 TAPTNATYPMPTAKEHyPVssPssPsPPAQPGGVsRNsPLD
O75376 S172 Sugiyama NCOR1 KIAA1047 KHEAPssPIsGQPCGDDQNAsPsKLSKEELIQSMDRVDREI
O75533 T211 Sugiyama SF3B1 SAP155 QPPsKRKRRWDQtADQtPGAtPKKLssWDQAEtPGHtPsLR
O94979 S188 Sugiyama SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334 PEDISCIAWNRQVQHILAsAsPsGRATVWDLRKNEPIIKVS
O94979 S799 Sugiyama SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334 IMQLRDRLCRAQGEPVAGHEsPKIPyEKQQLPKGRPGPVAG
O95297 S210 Sugiyama MPZL1 PZR UNQ849/PRO1787 LYRRKNSKRDyTGCstsEsLsPVKQAPRKsPsDtEGLVKSL
O95425 S920 Sugiyama SVIL LDHNAsAtDYKFSssIENsDsPVRSILKSQAWQPLVEGsEN
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00491 S176 Sugiyama PNP NP GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P03372 S104 SIGNOR|EPSD|PSP ESR1 ESR NR3A1 SEAAAFGSNGLGGFPPLNsVsPsPLMLLHPPPQLsPFLQPH
P03372 S106 SIGNOR|EPSD|PSP ESR1 ESR NR3A1 AAAFGSNGLGGFPPLNsVsPsPLMLLHPPPQLsPFLQPHGQ
P03372 S118 SIGNOR|EPSD|PSP ESR1 ESR NR3A1 PPLNsVsPsPLMLLHPPPQLsPFLQPHGQQVPYYLENEPSG
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05187 S177 Sugiyama ALPP PLAP RAKKAGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADVP
P05412 S63 SIGNOR|EPSD|PSP JUN ADPVGSLKPHLRAKNsDLLtsPDVGLLKLAsPELERLIIQS
P05412 S73 SIGNOR|EPSD|PSP JUN LRAKNsDLLtsPDVGLLKLAsPELERLIIQSSNGHItttPt
P06400 S807 GPS6|EPSD|PSP RB1 RsPyKFPssPLRIPGGNIyIsPLKsPYKIsEGLPtPtKMtP
P06400 S811 GPS6|SIGNOR|EPSD|PSP RB1 KFPssPLRIPGGNIyIsPLKsPYKIsEGLPtPtKMtPRSRI
P06493 Y15 Sugiyama CDK1 CDC2 CDC28A CDKN1 P34CDC2 ______MEDyTKIEKIGEGtyGVVyKGRHKTTGQVVAMKKI
P06733 S272 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 FRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsI
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06744 S455 Sugiyama GPI ALMRGKSTEEARKELQAAGKsPEDLERLLPHKVFEGNRPTN
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07437 T55 Sugiyama TUBB TUBB5 OK/SW-cl.56 tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07814 S886 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 EKTGKEyIPGQPPLsQssDssPtRNsEPAGLEtPEAKVLFD
P07858 S216 Sugiyama CTSB CPSB PPCTGEGDTPKCSKICEPGysPtyKQDKHYGYNSYSVSNSE
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P08195 S296 Sugiyama SLC3A2 MDU1 DLLQIDPNFGsKEDFDsLLQsAKKKSIRVILDLTPNYRGEN
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195 S607 Sugiyama SLC3A2 MDU1 ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P08238 S497 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08651 S323 Sugiyama NFIC NFI PssPtsSSRNWTEDMEGGIssPVKKtEMDKsPFNsPsPQDs
P08865 T97 Sugiyama RPSA LAMBR LAMR1 IssRNtGQRAVLKFAAAtGAtPIAGRFtPGTFTNQIQAAFR
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09923 S174 Sugiyama ALPI RAKQAGKSVGVVTTTRVQHAsPAGtyAHtVNRNWysDADMP
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7 T56 Sugiyama TUBA3C TUBA2 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
P11142 S85 Sugiyama HSPA8 HSC70 HSP73 HSPA10 NtVFDAKRLIGRRFDDAVVQsDMKHWPFMVVNDAGRPKVQV
P11142 T38 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13667 S379 Sugiyama PDIA4 ERP70 ERP72 QPEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGH
P14625 S552 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 KEKQDKIyFMAGsSRKEAEssPFVERLLKKGyEVIyLTEPV
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16949 S38 Sugiyama STMN1 C1orf215 LAP18 OP18 QAFELILsPRsKEsVPEFPLsPPKKKDLsLEEIQKKLEAAE
P17706 S304 Sugiyama PTPN2 PTPT SIQKRWKELsKEDLsPAFDHsPNKIMtEKYNGNRIGLEEEK
P17812 S575 Sugiyama CTPS1 CTPS LQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD____
P18124 T17 Sugiyama RPL7 ____MEGVEEKKKEVPAVPEtLKKKRRNFAELKIKRLRKKF
P18846 S63 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ATF1 DsSDsIGssQKAHGILARRPsYRKILKDLsSEDTRGRKGDG
P18858 S51 Sugiyama LIG1 TEPPPKAALKEWNGVVsEsDsPVKRPGRKAARVLGsEGEEE
P19338 S563 Sugiyama NCL CNKREIEGRAIRLELQGPRGsPNARSQPSKTLFVKGLsEDt
P20700 S23 Sugiyama LMNB1 LMN2 LMNB TAtPVPPRMGsRAGGPttPLsPtRLsRLQEKEELRELNDRL
P21333 S1084 Sugiyama FLNA FLN FLN1 PTKPSKVKAFGPGLQGGsAGsPARFtIDTKGAGTGGLGLTV
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22234 S27 Sugiyama PAICS ADE2 AIRC PAIS LNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAGNAARK
P22392 S120 Sugiyama NME2 NM23B KPGtIRGDFCIQVGRNIIHGsDsVKsAEKEISLWFKPEELV
P22392 S122 Sugiyama NME2 NM23B GtIRGDFCIQVGRNIIHGsDsVKsAEKEISLWFKPEELVDy
P22392 S125 Sugiyama NME2 NM23B RGDFCIQVGRNIIHGsDsVKsAEKEISLWFKPEELVDyKSC
P22626 S225 Sugiyama HNRNPA2B1 HNRPA2B1 GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P23284 T81 Sugiyama PPIB CYPB IFGLFGKTVPKTVDNFVALAtGEKGFGYKNSKFHRVIKDFM
P23526 S183 Sugiyama AHCY SAHH NLyKMMANGILKVPAINVNDsVtKsKFDNLyGCRESLIDGI
P23921 S559 Sugiyama RRM1 RR1 ALEASCDLAKEQGPyEtyEGsPVsKGILQYDMWNVTPTDLW
P24864 S387 Sugiyama CCNE1 CCNE LDLLDKARAKKAMLsEQNRAsPLPsGLLtPPQsGKKQSSGP
P24864 S399 Sugiyama CCNE1 CCNE MLsEQNRAsPLPsGLLtPPQsGKKQSSGPEMA_________
P24864 T36 Sugiyama CCNE1 CCNE MKEDGGAEFSARSRKRKANVtVFLQDPDEEMAKIDRTARDQ
P24864 T395 Sugiyama CCNE1 CCNE AKKAMLsEQNRAsPLPsGLLtPPQsGKKQSSGPEMA_____
P24928 S1917 Sugiyama POLR2A POLR2 PtsPVytPtsPKysPtsPtysPtsPKysPtsPtysPtsPKG
P24941 T160 Sugiyama CDK2 CDKN2 AIKLADFGLARAFGVPVRtytHEVVtLWyRAPEILLGCKYY
P24941 Y15 Sugiyama CDK2 CDKN2 ______MENFQKVEKIGEGtyGVVyKARNKLTGEVVALKKI
P25786 S14 Sugiyama PSMA1 HC2 NU PROS30 PSC2 _______MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQGSA
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27824 S583 Sugiyama CANX VsQEEEDRKPKAEEDEILNRsPRNRKPRRE___________
P29401 S548 Sugiyama TKT NIRVLDPFTIKPLDRKLILDsARAtKGRILTVEDHYYEGGI
P29692 S133 Sugiyama EEF1D EF1D NVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPAEDDE
P29966 S27 Sugiyama MARCKS MACS PRKCSL KTAAKGEAAAERPGEAAVAssPsKANGQENGHVKVNGDAsP
P30101 S443 Sugiyama PDIA3 ERP57 ERP60 GRP58 LsKDPNIVIAKMDAtANDVPsPyEVRGFPtIyFsPANKKLN
P31948 T243 Sugiyama STIP1 KQALKEKELGNDAYKKKDFDtALKHYDKAKELDPtNMtyIT
P33316 S99 Sugiyama DUT KGELPKAGGsPAPGPEtPAIsPsKRARPAEVGGMQLRFARL
P34897 S417 Sugiyama SHMT2 ERVLELVSITANKNTCPGDRsAItPGGLRLGAPALtSRQFR
P34897 T420 Sugiyama SHMT2 LELVSITANKNTCPGDRsAItPGGLRLGAPALtSRQFREDD
P34931 T40 Sugiyama HSPA1L VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P35579 S1892 Sugiyama MYH9 LKQLKRQLEEAEEEAQRANAsRRKLQRELEDAtEtADAMNR
P35611 S465 Sugiyama ADD1 ADDA tRWLNSGRGDEASEEGQNGssPKsKTKWTKEDGHRtstsAV
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T87 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKR
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P42677 S11 Sugiyama RPS27 MPS1 __________MPLAKDLLHPsPEEEKRKHKKKRLVQsPNsy
P43629 S296 iPTMNet KIR3DL1 CD158E NKAT3 NKB1 FQADFPLGPATHGGTYRCFGsFRHSPYEWSDPSDPLLVSVT
P46087 S732 Sugiyama NOP2 NOL1 NSUN1 AFLRQNAPPKGTDtQtPAVLsPsKtQAtLKPKDHHQPLGRA
P46531 S2513 SIGNOR|PSP NOTCH1 TAN1 PVDNTPSHQLQVPEHPFLtPsPEsPDQWssssPHSNVSDWS
P46531 S2516 SIGNOR|PSP NOTCH1 TAN1 NTPSHQLQVPEHPFLtPsPEsPDQWssssPHSNVSDWSEGV
P46531 T2511 SIGNOR|PSP NOTCH1 TAN1 SSPVDNTPSHQLQVPEHPFLtPsPEsPDQWssssPHSNVSD
P49736 S27 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 sFtMAssPAQRRRGNDPLtssPGRssRRtDALtssPGRDLP
P50914 S139 Sugiyama RPL14 RNRIIKNEVKKLQKAALLKAsPKKAPGTKGTAAAAAAAAAA
P51858 S165 Sugiyama HDGF HMG1L2 AKEKNEKGALKRRAGDLLEDsPKRPKEAENPEGEEKEAAtL
P51991 S358 Sugiyama HNRNPA3 HNRPA3 QQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF
P52564 S27 Sugiyama MAP2K6 MEK6 MKK6 PRKMK6 SKK3 KKRNPGLKIPKEAFEQPQtsstPPRDLDsKACISIGNQNFE
P54652 T39 Sugiyama HSPA2 VGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQ
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P61254 S32 Sugiyama RPL26 sKNRKRHFNAPsHIRRKIMssPLSKELRQKYNVRSMPIRKD
P61978 S284 Sugiyama HNRNPK HNRPK MPPGRGGRPMPPSRRDyDDMsPRRGPPPPPPGRGGRGGsRA
P62195 T109 Sugiyama PSMC5 SUG1 VHPEGKFVVDVDKNIDINDVtPNCRVALRNDsytLHKILPN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263 T133 Sugiyama RPS14 PRO2640 QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62750 S43 Sugiyama RPL23A KAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPRK
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62942 S9 Sugiyama FKBP1A FKBP1 FKBP12 ____________MGVQVEtIsPGDGRtFPKRGQtCVVHytG
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P68363 T56 Sugiyama TUBA1B MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
P85037 S420 Sugiyama FOXK1 MNF RGVSCFRtPFGPLssRsAPAsPtHPGLMsPRsGGLQtPECL
P85037 S428 Sugiyama FOXK1 MNF PFGPLssRsAPAsPtHPGLMsPRsGGLQtPECLsREGsPIP
Q00526 S207 iPTMNet CDK3 CDKN3 WSIGCIFAEMVTRKALFPGDsEIDQLFRIFRMLGTPSEDTW
Q00526 S288 Sugiyama CDK3 CDKN3 QYDPSQRITAKTALAHPYFSsPEPsPAARQYVLQRFRH___
Q00526 S292 Sugiyama CDK3 CDKN3 SQRITAKTALAHPYFSsPEPsPAARQYVLQRFRH_______
Q00526 T14 iPTMNet CDK3 CDKN3 _______MDMFQKVEKIGEGtyGVVyKAKNRETGQLVALKK
Q00526 T160 iPTMNet|Sugiyama CDK3 CDKN3 AIKLADFGLARAFGVPLRtYtHEVVTLWYRAPEILLGSKFY
Q00526 Y15 iPTMNet|Sugiyama CDK3 CDKN3 ______MDMFQKVEKIGEGtyGVVyKAKNRETGQLVALKKI
Q00526 Y19 iPTMNet CDK3 CDKN3 __MDMFQKVEKIGEGtyGVVyKAKNRETGQLVALKKIRLDL
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 S165 Sugiyama SET PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q03112 S624 SIGNOR MECOM EVI1 MDS1 PRDM3 DIESDKEKFKENGKMFKDKVsPLQNLASINNKKEYSNHSIF
Q04637 S1231 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI tEDRDRGRDAVKREAALPPVsPLKAALsEEELEKKsKAIIE
Q05682 T730 Sugiyama CALD1 CAD CDM RNIKsMWEKGNVFssPtAAGtPNKEtAGLKVGVSsRINEWL
Q08AD1 S1319 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 NEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWENAstts
Q08J23 S743 Sugiyama NSUN2 SAKI TRM4 AstGQPDNDVtEGQRAGEPNsPDAEEANsPDVtAGCDPAGV
Q12800 S309 SIGNOR|EPSD|PSP TFCP2 LSF SEF sPsPGFNSSHSSFSLGEGNGsPNHQPEPPPPVTDNLLPTTT
Q12802 S2728 Sugiyama AKAP13 BRX HT31 LBC PsPsAPSIAKsGsLDsELsVsPKRNsISRTHKDKGPFHILS
Q13200 S16 Sugiyama PSMD2 TRAP2 _____MEEGGRDKAPVQPQQsPAAAPGGtDEKPsGKERRDA
Q13247 S303 Sugiyama SRSF6 SFRS6 SRP55 ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283 S231 Sugiyama G3BP1 G3BP QEEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsW
Q13428 S1378 Sugiyama TCOF1 tPRSKKKKKLGAGEGGEAsVsPEKtsttSKGKAKRDKASGD
Q13573 S224 Sugiyama SNW1 SKIIP SKIP KDPMEPPRFKINKKIPRGPPsPPAPVMHsPsRKMTVKEQQE
Q13573 S232 Sugiyama SNW1 SKIIP SKIP FKINKKIPRGPPsPPAPVMHsPsRKMTVKEQQEWKIPPCIS
Q14103 S190 Sugiyama HNRNPD AUF1 HNRPD KRAKAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVES
Q14103 T193 Sugiyama HNRNPD AUF1 HNRPD KAMKTKEPVKKIFVGGLsPDtPEEKIREYFGGFGEVESIEL
Q14157 S416 Sugiyama UBAP2L KIAA0144 NICE4 tQsPsLVQYDLKNPsDsAVHsPFtKRQAFtPsstMMEVFLQ
Q14697 S58 Sugiyama GANAB G2AN KIAA0088 FKtCEEssFCKRQRsIRPGLsPyRALLDSLQLGPDSLTVHL
Q14934 S259 EPSD|PSP NFATC4 NFAT3 GGRGPEDSWLLLSAPGPtPAsPRPAsPCGKRRYsssGtPss
Q14980 S1757 Sugiyama NUMA1 NMP22 NUMA ITSKLPRtQPDGtsVPGEPAsPIsQRLPPKVEsLEsLyFtP
Q14980 T2000 Sugiyama NUMA1 NMP22 NUMA GITTRQQRKRVsLEPHQGPGtPEsKKATSCFPRPMtPRDRH
Q15084 S248 Sugiyama PDIA6 ERP5 P5 TXNDC7 LAsRYGIRGFPtIKIFQKGEsPVDyDGGRTRsDIVsRALDL
Q15154 S69 Sugiyama PCM1 KKKFGVESDKRVTNDISPESsPGVGRRRTKTPHTFPHSRYM
Q15181 S250 Sugiyama PPA1 IOPPP PP LVTKKTNGKGIsCMNttLsEsPFKCDPDAARAIVDALPPPC
Q15293 T76 Sugiyama RCN1 RCN FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD
Q15773 S238 Sugiyama MLF2 GAGGRRAEGPPRLAIQGPEDsPsRQsRRYDW__________
Q16204 S244 Sugiyama CCDC6 D10S170 TST1 LEAEKRILQEKLDQPVsAPPsPRDIsMEIDsPENMMRHIRF
Q16630 T157 Sugiyama CPSF6 CFIM68 SKKLMDLLPKRELHGQNPVVtPCNKQFLsQFEMQSRKTTQS
Q16881 T413 Sugiyama TXNRD1 GRIM12 KDRF HGIKFIRQFVPIKVEQIEAGtPGRLRVVAQSTNSEEIIEGE
Q53EL6 S94 Sugiyama PDCD4 H731 GDsVsDsGsDALRSGLtVPtsPKGRLLDRRSRSGKGRGLPK
Q58FF7 S370 Sugiyama HSP90AB3P HSP90BC KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q5R3I4 S362 Sugiyama TTC38 GAHDPQTTQELLTTLRDASEsPGENCQHLLARDVGLPLCQA
Q5TKA1 T96 SIGNOR|EPSD|PSP LIN9 BARA TGS sPKRNQRVAMVPQKFTATMstPDKKASQKIGFRLRNLLKLP
Q5VV41 S191 Sugiyama ARHGEF16 EPHEXIN4 NBR IQLsPKLQALAEEPsQPHtRsPAKNKKTLGRKRGHKGsFKD
Q69YN4 S1579 Sugiyama VIRMA KIAA1429 MSTP054 CCSDFDLHSELERsFLsEPssPGRtKTTKGFKLGKHKHETF
Q6P1L8 S49 Sugiyama MRPL14 MRPL32 RPML32 LSAIQKMTRVRVVDNSALGNsPyHRAPRCIHVYKKNGVGKV
Q6PEY2 T56 Sugiyama TUBA3E MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
Q6PKG0 S774 Sugiyama LARP1 KIAA0731 LARP LFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtPQLKDS
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZN18 S24 Sugiyama AEBP2 AItDMADLEELsRLsPLPPGsPGsAARGRAEPPEEEEEEEE
Q71U36 T56 Sugiyama TUBA1A TUBA3 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q7L2J0 S216 Sugiyama MEPCE BCDIN3 NLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDIt
Q7L2J0 S217 Sugiyama MEPCE BCDIN3 LNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPKDItD
Q7L2J0 T213 Sugiyama MEPCE BCDIN3 DPLNLNSLLDEEVSRtLNAEtPKssPLPAKGRDPVEILIPK
Q7Z417 S692 Sugiyama NUFIP2 KIAA1321 PIG1 IWNLQKQDPKRIItyNEAMDsPDQ_________________
Q7Z5K2 S226 Sugiyama WAPL FOE KIAA0261 WAPAL ETNDTWNSQFGKRPEsPsEIsPIKGsVRTGLFEWDNDFEDI
Q8IXQ3 S67 Sugiyama C9orf40 LGVPEQHRKRKIDAGTMAEPsAsPsKRRDsGDNsAPsGQER
Q8IXQ3 S69 Sugiyama C9orf40 VPEQHRKRKIDAGTMAEPsAsPsKRRDsGDNsAPsGQERED
Q8N556 S264 Sugiyama AFAP1 AFAP IKEAYSGCSGPVDSECPPPPssPVHKAELEKKLssERPssD
Q8NBJ5 S612 Sugiyama COLGALT1 GLT25D1 PSEC0241 QKMREQQALSREAKNsDVLQsPLDsAARDEL__________
Q8TDN4 S273 SIGNOR CABLES1 CABLES SRPTSQNYCSLEQPGQGGSTsAFEQLQRSRRRLIsQRssLE
Q8TDN4 S313 GPS6|EPSD|PSP CABLES1 CABLES EtLEDIEENAPLRRCRtLSGsPRPKNFKKIHFIKNMRQHDT
Q92530 S153 Sugiyama PSMF1 RIVSGIITPIHEQWEKANVssPHREFPPAtAREVDPLRIPP
Q96B36 S212 Sugiyama AKT1S1 PRAS40 GFKEKRtEARssDEENGPPssPDLDRIAAsMRALVLREAED
Q96C19 S74 Sugiyama EFHD2 SWS1 ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96MH2 S76 Sugiyama HEXIM2 L3 EDLAGAVGGLGWNsRsPRtQsPGGCsAEAVLARKKHRRRPS
Q96T37 S670 Sugiyama RBM15 OTT OTT1 GRHLDRsPEsDRPRKRHCAPsPDRsPELsssRDRYNsDNDR
Q9BQE3 T56 Sugiyama TUBA1C TUBA6 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q9BXP5 S493 Sugiyama SRRT ARS2 ASR2 VNIKEICWNLQNIRLRECELsPGVNRDLTRRVRNINGITQH
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9C0C2 S435 Sugiyama TNKS1BP1 KIAA1741 TAB182 DAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAALPQGQG
Q9H2U2 S316 Sugiyama PPA2 HSPC124 SDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLGK__
Q9H6F5 S102 Sugiyama CCDC86 CYCLON QGQPEPGAAsPQRQQDLHLEsPQRQPEysPEsPRCQPKPSE
Q9H6F5 S91 Sugiyama CCDC86 CYCLON RLQQGAGLEsPQGQPEPGAAsPQRQQDLHLEsPQRQPEysP
Q9H773 S85 Sugiyama DCTPP1 XTP3TPA CDA03 GELAELFQWKTDGEPGPQGWsPRERAALQEELSDVLIYLVA
Q9NQR4 S207 Sugiyama NIT2 CUA002 HWELLQRSRAVDNQVyVAtAsPARDDKASYVAWGHSTVVNP
Q9NY27 S226 Sugiyama PPP4R2 SBBI57 QNEEKNHSDsstsEsEVssVsPLKNKHPDEDAVEAEGHEVK
Q9NZT2 S378 Sugiyama OGFR LERsQGDEAGGHGEDRPEPLsPKEsKKRKLELSRREQPPTE
Q9UG63 S512 Sugiyama ABCF2 HUSSY-18 EKEEMRKIIGRYGLTGKQQVsPIRNLSDGQKCRVCLAWLAW
Q9UJU6 S232 Sugiyama DBNL CMAP SH3P7 PP5423 RELREAARREQRyQEQGGEAsPQRtWEQQQEVVSRNRNEQE
Q9UNE7 S19 Sugiyama STUB1 CHIP PP1131 __MKGKEEKEGGARLGAGGGsPEKsPsAQELKEQGNRLFVG
Q9UNX3 S32 Sugiyama RPL26L1 RPL26P1 sKNRKRHFNAPSHVRRKIMssPLSKELRQKYNVRSMPIRKD
Q9UPQ0 S523 Sugiyama LIMCH1 KIAA1102 VETTIARASVLDtsMsAGsGsPsKTVtPKAVPMLtPKPYsQ
Q9UPT8 S143 Sugiyama ZC3H4 C19orf7 KIAA1064 KSKHKRHAsSSDDFsDFsDDsDFsPSEKGHRKyREysPPyA
Q9UPT8 S146 Sugiyama ZC3H4 C19orf7 KIAA1064 HKRHAsSSDDFsDFsDDsDFsPSEKGHRKyREysPPyAPsH
Q9UQ35 S875 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ItsPQANEQsVtPQRRsCFEssPDPELKsRtPsRHsCsGss
Q9UQ35 S994 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPDtKVKPEtPPRQsHsGsIsPyPKVKAQtPPGPsLsGsKs
Q9UQ35 T1655 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 RSRSGSSSKGRGPsPEGssstEssPEHPPKSRTARRGsRSs
Q9UQ35 T2104 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 SSDRSRsAtPPATRNHsGsRtPPVALNsSRMsCFsRPsMsP
Q9Y2X3 S514 Sugiyama NOP58 NOL5 NOP5 HSPC120 KHIKEEPLsEEEPCtstAIAsPEKKKKKKKKRENED_____
Q9Y6G9 S207 Sugiyama DYNC1LI1 DNCLI1 EQKLIRDFQEyVEPGEDFPAsPQRRNtAsQEDKDDsVVLPL
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.597922e-14 13.585 0 0
Cell Cycle, Mitotic R-HSA-69278 7.177592e-13 12.144 0 0
Chromatin organization R-HSA-4839726 3.445049e-09 8.463 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.048052e-08 7.689 0 0
Chromatin modifying enzymes R-HSA-3247509 1.855103e-08 7.732 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.904508e-07 6.720 0 0
G1/S-Specific Transcription R-HSA-69205 4.204044e-07 6.376 0 0
Gene expression (Transcription) R-HSA-74160 4.997172e-07 6.301 0 0
PKMTs methylate histone lysines R-HSA-3214841 6.384500e-07 6.195 0 0
G0 and Early G1 R-HSA-1538133 1.041335e-06 5.982 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.144177e-06 5.942 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.604590e-06 5.795 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.462515e-06 5.461 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.093740e-05 4.961 0 0
Cell Cycle Checkpoints R-HSA-69620 2.326790e-05 4.633 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.930974e-05 4.405 0 0
Cellular Senescence R-HSA-2559583 4.943748e-05 4.306 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.492332e-05 4.260 0 0
Regulation of TP53 Activity R-HSA-5633007 5.804707e-05 4.236 0 0
M Phase R-HSA-68886 6.265547e-05 4.203 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.143715e-05 4.089 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.035435e-04 3.985 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.035689e-04 3.985 0 0
S Phase R-HSA-69242 2.039235e-04 3.691 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.415624e-04 3.617 0 0
Apoptotic execution phase R-HSA-75153 3.413999e-04 3.467 0 0
Homology Directed Repair R-HSA-5693538 3.763930e-04 3.424 0 0
Mitotic Prometaphase R-HSA-68877 3.787148e-04 3.422 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.178071e-04 3.379 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.559231e-04 3.341 0 0
G1/S Transition R-HSA-69206 5.110455e-04 3.292 0 0
RNA Polymerase II Transcription R-HSA-73857 6.043428e-04 3.219 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 9.177926e-04 3.037 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 9.177926e-04 3.037 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.524896e-04 3.021 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.002411e-03 2.999 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.207517e-03 2.918 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.420798e-03 2.847 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.675502e-03 2.776 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.675502e-03 2.776 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.952668e-03 2.709 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.952668e-03 2.709 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.874700e-03 2.727 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.916521e-03 2.717 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.969321e-03 2.706 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.162055e-03 2.665 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.217859e-03 2.654 0 0
NRAGE signals death through JNK R-HSA-193648 2.226143e-03 2.652 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.437675e-03 2.613 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.482892e-03 2.605 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.647152e-03 2.577 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.579846e-03 2.588 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.702897e-03 2.568 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.760077e-03 2.559 0 0
Generic Transcription Pathway R-HSA-212436 2.969896e-03 2.527 0 0
HATs acetylate histones R-HSA-3214847 3.088042e-03 2.510 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.103507e-03 2.508 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.250948e-03 2.488 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.250948e-03 2.488 0 0
Nuclear import of Rev protein R-HSA-180746 3.250948e-03 2.488 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.439540e-03 2.463 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.844023e-03 2.415 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.844023e-03 2.415 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.962207e-03 2.402 0 0
G1 Phase R-HSA-69236 3.945627e-03 2.404 0 0
Cyclin D associated events in G1 R-HSA-69231 3.945627e-03 2.404 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.988601e-03 2.399 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.988601e-03 2.399 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.201392e-03 2.377 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.720336e-03 2.326 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.136674e-03 2.289 0 0
Mitotic Anaphase R-HSA-68882 4.995372e-03 2.301 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.176984e-03 2.286 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.391585e-03 2.268 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.749268e-03 2.240 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.749268e-03 2.240 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.761093e-03 2.239 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.749268e-03 2.240 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.372877e-03 2.270 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.749268e-03 2.240 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.761093e-03 2.239 0 0
Diseases of DNA repair R-HSA-9675135 5.507562e-03 2.259 0 0
Separation of Sister Chromatids R-HSA-2467813 5.879863e-03 2.231 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.266793e-03 2.203 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.820116e-03 2.166 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.877522e-03 2.163 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 6.786223e-03 2.168 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.877522e-03 2.163 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.948465e-03 2.158 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.948465e-03 2.158 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.564321e-03 2.121 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.391212e-03 2.131 0 0
Processing of DNA double-strand break ends R-HSA-5693607 7.391143e-03 2.131 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 7.177644e-03 2.144 0 0
Regulation of endogenous retroelements R-HSA-9842860 8.072992e-03 2.093 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.158867e-03 2.088 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 8.166161e-03 2.088 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.892293e-03 2.005 0 0
Mitotic G2-G2/M phases R-HSA-453274 9.534136e-03 2.021 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.620982e-03 2.017 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 9.898545e-03 2.004 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 9.931633e-03 2.003 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.040846e-02 1.983 0 0
Mitotic Prophase R-HSA-68875 1.079599e-02 1.967 0 0
Polo-like kinase mediated events R-HSA-156711 1.128694e-02 1.947 0 0
DNA Repair R-HSA-73894 1.153701e-02 1.938 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.295994e-02 1.887 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.240836e-02 1.906 0 0
G2/M Transition R-HSA-69275 1.298637e-02 1.887 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.410759e-02 1.851 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.421537e-02 1.847 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.436736e-02 1.843 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.442745e-02 1.841 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.570840e-02 1.804 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.766085e-02 1.753 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.766085e-02 1.753 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.766085e-02 1.753 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.766085e-02 1.753 0 0
Deadenylation of mRNA R-HSA-429947 1.786812e-02 1.748 0 0
DNA Damage Bypass R-HSA-73893 1.875321e-02 1.727 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.877860e-02 1.726 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.877860e-02 1.726 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.894999e-02 1.722 0 0
G alpha (12/13) signalling events R-HSA-416482 1.919471e-02 1.717 0 0
Disorders of Developmental Biology R-HSA-9675151 2.104337e-02 1.677 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.104337e-02 1.677 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.104337e-02 1.677 0 0
Activation of BH3-only proteins R-HSA-114452 2.082633e-02 1.681 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.109555e-02 1.676 0 0
G2/M Checkpoints R-HSA-69481 2.111541e-02 1.675 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.113444e-02 1.675 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.474333e-02 1.607 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.318005e-02 1.635 0 0
Frs2-mediated activation R-HSA-170968 2.474333e-02 1.607 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.474333e-02 1.607 0 0
Signalling to ERKs R-HSA-187687 2.315850e-02 1.635 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.495529e-02 1.603 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.617327e-02 1.582 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.683619e-02 1.571 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.793070e-02 1.554 0 0
MET interacts with TNS proteins R-HSA-8875513 2.793070e-02 1.554 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.793070e-02 1.554 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.793070e-02 1.554 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.818278e-02 1.550 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.835231e-02 1.547 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.835231e-02 1.547 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.065825e-02 1.513 0 0
Metabolism of non-coding RNA R-HSA-194441 3.123951e-02 1.505 0 0
snRNP Assembly R-HSA-191859 3.123951e-02 1.505 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.860272e-02 1.544 0 0
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells R-HSA-210746 3.065825e-02 1.513 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.138266e-02 1.503 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.209558e-02 1.494 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.282834e-02 1.484 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.321268e-02 1.479 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.321268e-02 1.479 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.745400e-02 1.427 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.829421e-02 1.417 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.829421e-02 1.417 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.843376e-02 1.415 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.234044e-02 1.373 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.234044e-02 1.373 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.234044e-02 1.373 0 0
Translesion Synthesis by POLH R-HSA-110320 3.885211e-02 1.411 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.885211e-02 1.411 0 0
Heme signaling R-HSA-9707616 4.276588e-02 1.369 0 0
tRNA processing in the nucleus R-HSA-6784531 4.276588e-02 1.369 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.155398e-02 1.381 0 0
Regulation of gap junction activity R-HSA-191650 4.396875e-02 1.357 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.396875e-02 1.357 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.396875e-02 1.357 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.396875e-02 1.357 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.396875e-02 1.357 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.396875e-02 1.357 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.408422e-02 1.356 0 0
Death Receptor Signaling R-HSA-73887 4.452632e-02 1.351 0 0
Centrosome maturation R-HSA-380287 4.622180e-02 1.335 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.668267e-02 1.331 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.668267e-02 1.331 0 0
Prolonged ERK activation events R-HSA-169893 4.789476e-02 1.320 0 0
Type I hemidesmosome assembly R-HSA-446107 5.620052e-02 1.250 0 0
Formation of annular gap junctions R-HSA-196025 5.620052e-02 1.250 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.499646e-02 1.260 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.144312e-02 1.289 0 0
TGFBR3 expression R-HSA-9839394 5.144312e-02 1.289 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.145876e-02 1.289 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.145876e-02 1.289 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.145876e-02 1.289 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.620052e-02 1.250 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.223052e-02 1.282 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.667914e-02 1.247 0 0
RNA Polymerase III Transcription R-HSA-74158 5.667914e-02 1.247 0 0
RET signaling R-HSA-8853659 5.667914e-02 1.247 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.954951e-02 1.225 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.954951e-02 1.225 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.990960e-02 1.223 0 0
AURKA Activation by TPX2 R-HSA-8854518 6.242969e-02 1.205 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.365138e-02 1.196 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.365138e-02 1.196 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.365138e-02 1.196 0 0
GP1b-IX-V activation signalling R-HSA-430116 7.220207e-02 1.141 0 0
Gap junction degradation R-HSA-190873 7.220207e-02 1.141 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.952471e-02 1.158 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.665360e-02 1.176 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.645364e-02 1.177 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 6.442771e-02 1.191 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.390470e-02 1.194 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 7.220207e-02 1.141 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 7.065761e-02 1.151 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.481656e-02 1.188 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.462687e-02 1.190 0 0
Signaling by ALK in cancer R-HSA-9700206 6.481656e-02 1.188 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.220207e-02 1.141 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.220207e-02 1.141 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.650684e-02 1.116 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.805132e-02 1.108 0 0
Cellular response to heat stress R-HSA-3371556 7.814754e-02 1.107 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.843502e-02 1.105 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 8.006231e-02 1.097 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.114936e-02 1.091 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 9.543674e-02 1.020 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 9.543674e-02 1.020 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 9.543674e-02 1.020 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 9.543674e-02 1.020 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 9.543674e-02 1.020 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 9.543674e-02 1.020 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 9.543674e-02 1.020 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 9.543674e-02 1.020 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 9.543674e-02 1.020 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 9.543674e-02 1.020 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 9.543674e-02 1.020 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 9.543674e-02 1.020 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.667973e-02 1.062 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 8.667973e-02 1.062 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 8.667973e-02 1.062 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.450681e-02 1.025 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.803814e-02 1.055 0 0
Nucleosome assembly R-HSA-774815 8.803814e-02 1.055 0 0
mRNA 3'-end processing R-HSA-72187 9.482528e-02 1.023 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.426728e-02 1.026 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 9.507003e-02 1.022 0 0
Mitophagy R-HSA-5205647 8.925792e-02 1.049 0 0
Receptor Mediated Mitophagy R-HSA-8934903 9.026070e-02 1.045 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 8.667973e-02 1.062 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 8.667973e-02 1.062 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 8.667973e-02 1.062 0 0
Rap1 signalling R-HSA-392517 9.450681e-02 1.025 0 0
Deubiquitination R-HSA-5688426 9.256504e-02 1.034 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.687720e-02 1.014 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.687720e-02 1.014 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.687720e-02 1.014 0 0
Signaling by RAS mutants R-HSA-6802949 9.687720e-02 1.014 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 9.820992e-02 1.008 0 0
Synthesis of DNA R-HSA-69239 9.933894e-02 1.003 0 0
Oncogene Induced Senescence R-HSA-2559585 9.954535e-02 1.002 0 0
Activation of the pre-replicative complex R-HSA-68962 9.962389e-02 1.002 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.962389e-02 1.002 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.962389e-02 1.002 0 0
Apoptosis R-HSA-109581 1.004165e-01 0.998 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.006224e-01 0.997 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.019811e-01 0.991 0 0
Translesion synthesis by REV1 R-HSA-110312 1.029760e-01 0.987 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.034079e-01 0.985 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.212868e-01 0.916 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.212868e-01 0.916 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.212868e-01 0.916 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.212868e-01 0.916 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.212868e-01 0.916 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.212868e-01 0.916 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.212868e-01 0.916 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.212868e-01 0.916 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.126744e-01 0.948 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.102525e-01 0.958 0 0
Translesion synthesis by POLI R-HSA-5656121 1.204602e-01 0.919 0 0
Phosphorylation of the APC/C R-HSA-176412 1.204602e-01 0.919 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.252663e-01 0.902 0 0
RUNX2 regulates bone development R-HSA-8941326 1.104842e-01 0.957 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.220643e-01 0.913 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.091537e-01 0.962 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.146047e-01 0.941 0 0
mRNA Splicing R-HSA-72172 1.128951e-01 0.947 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.192680e-01 0.923 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.252663e-01 0.902 0 0
Negative regulation of MET activity R-HSA-6807004 1.089655e-01 0.963 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.274556e-01 0.895 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.229763e-01 0.910 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.244864e-01 0.905 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 1.320223e-01 0.879 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.320223e-01 0.879 0 0
Signaling by EGFR R-HSA-177929 1.323374e-01 0.878 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.323374e-01 0.878 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.372168e-01 0.863 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.372168e-01 0.863 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.374069e-01 0.862 0 0
Integrin signaling R-HSA-354192 1.375869e-01 0.861 0 0
Nuclear RNA decay R-HSA-9930044 1.375869e-01 0.861 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.392286e-01 0.856 0 0
Translesion synthesis by POLK R-HSA-5655862 1.392286e-01 0.856 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.400553e-01 0.854 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.278693e-01 0.642 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.278693e-01 0.642 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.278693e-01 0.642 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.278693e-01 0.642 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.278693e-01 0.642 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.278693e-01 0.642 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.278693e-01 0.642 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.278693e-01 0.642 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.278693e-01 0.642 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.278693e-01 0.642 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.278693e-01 0.642 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.278693e-01 0.642 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.825058e-01 0.739 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.825058e-01 0.739 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.825058e-01 0.739 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.825058e-01 0.739 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.825058e-01 0.739 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.825058e-01 0.739 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 3.215294e-01 0.493 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.215294e-01 0.493 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.215294e-01 0.493 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.215294e-01 0.493 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.215294e-01 0.493 0 0
3-hydroxyisobutyryl-CoA hydrolase deficiency R-HSA-9916722 3.215294e-01 0.493 0 0
Intestinal infectious diseases R-HSA-8942233 3.215294e-01 0.493 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.215294e-01 0.493 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.215294e-01 0.493 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.215294e-01 0.493 0 0
Defective SLC9A9 causes autism 16 (AUTS16) R-HSA-5619052 3.215294e-01 0.493 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 1.412113e-01 0.850 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.412113e-01 0.850 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.293580e-01 0.639 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.293580e-01 0.639 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.293580e-01 0.639 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.293580e-01 0.639 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.718490e-01 0.765 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.718490e-01 0.765 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.718490e-01 0.765 0 0
Disorders of Nervous System Development R-HSA-9697154 1.553917e-01 0.809 0 0
Pervasive developmental disorders R-HSA-9005895 1.553917e-01 0.809 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.553917e-01 0.809 0 0
Leading Strand Synthesis R-HSA-69109 1.553917e-01 0.809 0 0
Polymerase switching R-HSA-69091 1.553917e-01 0.809 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.553917e-01 0.809 0 0
ALK mutants bind TKIs R-HSA-9700645 2.041477e-01 0.690 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.768753e-01 0.558 0 0
Phosphorylation of Emi1 R-HSA-176417 2.768753e-01 0.558 0 0
Synthesis of PS R-HSA-1483101 2.768753e-01 0.558 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.768753e-01 0.558 0 0
Signaling by RNF43 mutants R-HSA-5340588 2.768753e-01 0.558 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.038333e-01 0.394 0 0
Defective OPLAH causes OPLAHD R-HSA-5578998 4.038333e-01 0.394 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.038333e-01 0.394 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.038333e-01 0.394 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.038333e-01 0.394 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.801664e-01 0.744 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 2.376846e-01 0.624 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.376846e-01 0.624 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.376846e-01 0.624 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.410196e-01 0.851 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.061423e-01 0.686 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.242077e-01 0.489 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.585061e-01 0.800 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.069157e-01 0.513 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.707011e-01 0.431 0 0
SOS-mediated signalling R-HSA-112412 3.707011e-01 0.431 0 0
Invadopodia formation R-HSA-8941237 4.761573e-01 0.322 0 0
MET activates PTPN11 R-HSA-8865999 4.761573e-01 0.322 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.663875e-01 0.779 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.890411e-01 0.723 0 0
Lagging Strand Synthesis R-HSA-69186 2.486139e-01 0.604 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.486139e-01 0.604 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.365521e-01 0.626 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.419160e-01 0.466 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.419160e-01 0.466 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.727578e-01 0.564 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.727578e-01 0.564 0 0
MAP2K and MAPK activation R-HSA-5674135 1.889569e-01 0.724 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.158631e-01 0.381 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.158631e-01 0.381 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.158631e-01 0.381 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.726573e-01 0.763 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 2.973641e-01 0.527 0 0
Notch-HLH transcription pathway R-HSA-350054 2.973641e-01 0.527 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.579245e-01 0.802 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.767714e-01 0.424 0 0
Formation of axial mesoderm R-HSA-9796292 3.767714e-01 0.424 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.468789e-01 0.460 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.468789e-01 0.460 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.223093e-01 0.492 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.474734e-01 0.459 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 4.593326e-01 0.338 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.397110e-01 0.268 0 0
HCN channels R-HSA-1296061 5.397110e-01 0.268 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.397110e-01 0.268 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.397110e-01 0.268 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.397110e-01 0.268 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.397110e-01 0.268 0 0
Signaling by LRP5 mutants R-HSA-5339717 5.397110e-01 0.268 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.967299e-01 0.706 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.851448e-01 0.545 0 0
HDACs deacetylate histones R-HSA-3214815 3.013657e-01 0.521 0 0
Erythropoietin activates RAS R-HSA-9027284 4.450664e-01 0.352 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.450664e-01 0.352 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.178101e-01 0.498 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 3.126565e-01 0.505 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.008558e-01 0.300 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.008558e-01 0.300 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.275948e-01 0.485 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.275948e-01 0.485 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.231632e-01 0.373 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.791741e-01 0.554 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.781050e-01 0.320 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.985703e-01 0.399 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 4.614919e-01 0.336 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.614919e-01 0.336 0 0
Meiotic synapsis R-HSA-1221632 3.916330e-01 0.407 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.916330e-01 0.407 0 0
Dual Incision in GG-NER R-HSA-5696400 4.367672e-01 0.360 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.178633e-01 0.379 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.021874e-01 0.396 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.277847e-01 0.369 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.101923e-01 0.292 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.402651e-01 0.267 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.402651e-01 0.267 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.955574e-01 0.225 0 0
IRS activation R-HSA-74713 5.955574e-01 0.225 0 0
G2 Phase R-HSA-68911 5.955574e-01 0.225 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.955574e-01 0.225 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.955574e-01 0.225 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.955574e-01 0.225 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.955574e-01 0.225 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.955574e-01 0.225 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.458182e-01 0.351 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 4.680134e-01 0.330 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.416370e-01 0.355 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.412075e-01 0.267 0 0
Orc1 removal from chromatin R-HSA-68949 5.129204e-01 0.290 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.129204e-01 0.290 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.129204e-01 0.290 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.774624e-01 0.238 0 0
Anchoring fibril formation R-HSA-2214320 5.774624e-01 0.238 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.774624e-01 0.238 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.774624e-01 0.238 0 0
PPARA activates gene expression R-HSA-1989781 4.749113e-01 0.323 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.079018e-01 0.294 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.313751e-01 0.275 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.313751e-01 0.275 0 0
PKA activation R-HSA-163615 5.710563e-01 0.243 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.710563e-01 0.243 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.478207e-01 0.261 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.478207e-01 0.261 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.512804e-01 0.259 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.671371e-01 0.246 0 0
Attenuation phase R-HSA-3371568 5.668184e-01 0.247 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.707592e-01 0.244 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 5.996690e-01 0.222 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.124043e-01 0.213 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.124043e-01 0.213 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.446309e-01 0.191 0 0
PKB-mediated events R-HSA-109703 6.446309e-01 0.191 0 0
Cam-PDE 1 activation R-HSA-111957 6.446309e-01 0.191 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.446309e-01 0.191 0 0
PDE3B signalling R-HSA-165160 6.446309e-01 0.191 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.446309e-01 0.191 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.446309e-01 0.191 0 0
Signaling by MAPK mutants R-HSA-9652817 6.446309e-01 0.191 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.109180e-01 0.214 0 0
HSF1-dependent transactivation R-HSA-3371571 6.395518e-01 0.194 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 6.450905e-01 0.190 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.450905e-01 0.190 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.520104e-01 0.186 0 0
Signaling by Erythropoietin R-HSA-9006335 6.622228e-01 0.179 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.622228e-01 0.179 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.622228e-01 0.179 0 0
Voltage gated Potassium channels R-HSA-1296072 6.714869e-01 0.173 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.833986e-01 0.165 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.877526e-01 0.163 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.877526e-01 0.163 0 0
Signaling by LTK in cancer R-HSA-9842640 6.877526e-01 0.163 0 0
STAT5 Activation R-HSA-9645135 6.877526e-01 0.163 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.877526e-01 0.163 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.877526e-01 0.163 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.877526e-01 0.163 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.010602e-01 0.154 0 0
Signaling by NOTCH3 R-HSA-9012852 3.013657e-01 0.521 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.986709e-01 0.399 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.744567e-01 0.758 0 0
Circadian clock R-HSA-9909396 3.642301e-01 0.439 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.573689e-01 0.447 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 4.137310e-01 0.383 0 0
EGFR downregulation R-HSA-182971 5.209583e-01 0.283 0 0
Downstream signal transduction R-HSA-186763 3.461252e-01 0.461 0 0
Chromosome Maintenance R-HSA-73886 3.010233e-01 0.521 0 0
Nucleotide Excision Repair R-HSA-5696398 3.478370e-01 0.459 0 0
FOXO-mediated transcription R-HSA-9614085 1.882984e-01 0.725 0 0
RAF activation R-HSA-5673000 1.663875e-01 0.779 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.727578e-01 0.564 0 0
DNA Double Strand Break Response R-HSA-5693606 1.801473e-01 0.744 0 0
MET promotes cell motility R-HSA-8875878 3.644775e-01 0.438 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.341827e-01 0.272 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.412075e-01 0.267 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.236387e-01 0.281 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.269973e-01 0.203 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.069593e-01 0.684 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.069593e-01 0.684 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.139720e-01 0.503 0 0
Extension of Telomeres R-HSA-180786 6.355754e-01 0.197 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.553917e-01 0.809 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.085560e-01 0.681 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.516508e-01 0.599 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.474788e-01 0.349 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.727892e-01 0.325 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.379225e-01 0.471 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.124043e-01 0.213 0 0
IRS-mediated signalling R-HSA-112399 6.022516e-01 0.220 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.068826e-01 0.217 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.069593e-01 0.684 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 4.268123e-01 0.370 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.160289e-01 0.287 0 0
DNA strand elongation R-HSA-69190 3.687808e-01 0.433 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.960641e-01 0.708 0 0
Neurodegenerative Diseases R-HSA-8863678 1.960641e-01 0.708 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.917971e-01 0.717 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.889569e-01 0.724 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.511115e-01 0.821 0 0
RNA Polymerase I Transcription R-HSA-73864 5.546119e-01 0.256 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 6.622228e-01 0.179 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.180152e-01 0.662 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.951463e-01 0.158 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.159829e-01 0.666 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.543855e-01 0.595 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.101923e-01 0.292 0 0
PI3K Cascade R-HSA-109704 6.220751e-01 0.206 0 0
Interleukin-15 signaling R-HSA-8983432 3.419160e-01 0.466 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.101923e-01 0.292 0 0
Meiosis R-HSA-1500620 4.268123e-01 0.370 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.768491e-01 0.752 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.768491e-01 0.752 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.768491e-01 0.752 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.768491e-01 0.752 0 0
DNA Replication R-HSA-69306 2.290567e-01 0.640 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 3.681416e-01 0.434 0 0
Signaling by ERBB2 R-HSA-1227986 5.168555e-01 0.287 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.651005e-01 0.782 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.973641e-01 0.527 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.613095e-01 0.792 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.631748e-01 0.580 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.112274e-01 0.386 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.576861e-01 0.589 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.438038e-01 0.842 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.367672e-01 0.360 0 0
Signaling by NOTCH R-HSA-157118 5.662487e-01 0.247 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.069157e-01 0.513 0 0
Signaling by NOTCH1 R-HSA-1980143 2.054612e-01 0.687 0 0
Mismatch Repair R-HSA-5358508 5.710563e-01 0.243 0 0
IGF1R signaling cascade R-HSA-2428924 5.846888e-01 0.233 0 0
Adipogenesis R-HSA-9843745 3.529510e-01 0.452 0 0
Dopamine receptors R-HSA-390651 1.825058e-01 0.739 0 0
Activation of RAC1 R-HSA-428540 3.069157e-01 0.513 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.419160e-01 0.466 0 0
Adrenoceptors R-HSA-390696 4.158631e-01 0.381 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.792977e-01 0.554 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.397110e-01 0.268 0 0
Telomere C-strand synthesis initiation R-HSA-174430 4.450664e-01 0.352 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.231632e-01 0.373 0 0
mTORC1-mediated signalling R-HSA-166208 4.891817e-01 0.311 0 0
Fibronectin matrix formation R-HSA-1566977 5.101923e-01 0.292 0 0
Reelin signalling pathway R-HSA-8866376 5.955574e-01 0.225 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.668184e-01 0.247 0 0
Signaling by NOTCH4 R-HSA-9013694 6.152605e-01 0.211 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.170571e-01 0.210 0 0
Protein folding R-HSA-391251 6.663039e-01 0.176 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 6.450905e-01 0.190 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.010602e-01 0.154 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.768491e-01 0.752 0 0
Rab regulation of trafficking R-HSA-9007101 4.299190e-01 0.367 0 0
Neurexins and neuroligins R-HSA-6794361 3.735903e-01 0.428 0 0
Interleukin-2 signaling R-HSA-9020558 5.402651e-01 0.267 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.774624e-01 0.238 0 0
Selective autophagy R-HSA-9663891 2.785697e-01 0.555 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.140371e-01 0.212 0 0
Mitochondrial biogenesis R-HSA-1592230 5.265878e-01 0.279 0 0
Macroautophagy R-HSA-1632852 5.679381e-01 0.246 0 0
Repression of WNT target genes R-HSA-4641265 3.419160e-01 0.466 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.727578e-01 0.564 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.287260e-01 0.641 0 0
Signal attenuation R-HSA-74749 5.008558e-01 0.300 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.439054e-01 0.464 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.124043e-01 0.213 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.732158e-01 0.428 0 0
Cardiogenesis R-HSA-9733709 3.914902e-01 0.407 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.141766e-01 0.383 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.501273e-01 0.347 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.985236e-01 0.525 0 0
MAPK family signaling cascades R-HSA-5683057 6.044117e-01 0.219 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.672502e-01 0.573 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.889569e-01 0.724 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.009554e-01 0.221 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.562924e-01 0.341 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.562924e-01 0.341 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.293580e-01 0.639 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.802201e-01 0.744 0 0
DCC mediated attractive signaling R-HSA-418885 2.331118e-01 0.632 0 0
PTK6 Expression R-HSA-8849473 3.707011e-01 0.431 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 3.419160e-01 0.466 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 3.419160e-01 0.466 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.688521e-01 0.772 0 0
Calcineurin activates NFAT R-HSA-2025928 4.593326e-01 0.338 0 0
Signaling by MET R-HSA-6806834 2.543855e-01 0.595 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.543855e-01 0.595 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.965653e-01 0.706 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.332958e-01 0.363 0 0
Josephin domain DUBs R-HSA-5689877 5.008558e-01 0.300 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.402651e-01 0.267 0 0
Formation of the posterior neural plate R-HSA-9832991 5.402651e-01 0.267 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.955574e-01 0.225 0 0
PTK6 Down-Regulation R-HSA-8849472 5.955574e-01 0.225 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.955574e-01 0.225 0 0
Activation of AKT2 R-HSA-165158 5.955574e-01 0.225 0 0
Membrane Trafficking R-HSA-199991 1.886116e-01 0.724 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.774624e-01 0.238 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.283033e-01 0.277 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.931090e-01 0.227 0 0
COPI-mediated anterograde transport R-HSA-6807878 6.256615e-01 0.204 0 0
ESR-mediated signaling R-HSA-8939211 6.754531e-01 0.170 0 0
Signaling by NODAL R-HSA-1181150 6.269973e-01 0.203 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.530118e-01 0.185 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.474788e-01 0.349 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.401035e-01 0.194 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.622228e-01 0.179 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.106243e-01 0.508 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.694921e-01 0.771 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.450664e-01 0.352 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.737995e-01 0.324 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.682949e-01 0.245 0 0
Collagen formation R-HSA-1474290 6.912753e-01 0.160 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.173283e-01 0.498 0 0
TNF signaling R-HSA-75893 3.178101e-01 0.498 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.231632e-01 0.373 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.844899e-01 0.546 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.931090e-01 0.227 0 0
Signaling by FGFR4 R-HSA-5654743 6.448236e-01 0.191 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.973641e-01 0.527 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.593326e-01 0.338 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.397110e-01 0.268 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.397110e-01 0.268 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.047070e-01 0.393 0 0
p38MAPK events R-HSA-171007 4.450664e-01 0.352 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.450664e-01 0.352 0 0
Ub-specific processing proteases R-HSA-5689880 3.566838e-01 0.448 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 5.774624e-01 0.238 0 0
Autophagy R-HSA-9612973 5.705901e-01 0.244 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.182345e-01 0.285 0 0
Signaling by SCF-KIT R-HSA-1433557 6.448236e-01 0.191 0 0
MTOR signalling R-HSA-165159 6.261311e-01 0.203 0 0
Cellular responses to stress R-HSA-2262752 2.055567e-01 0.687 0 0
Signaling by FGFR3 R-HSA-5654741 6.804662e-01 0.167 0 0
Signaling by TGFB family members R-HSA-9006936 3.661017e-01 0.436 0 0
Interleukin-2 family signaling R-HSA-451927 5.668184e-01 0.247 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.268123e-01 0.370 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.013657e-01 0.521 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.060419e-01 0.391 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.060419e-01 0.391 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.530118e-01 0.185 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.833986e-01 0.165 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.877526e-01 0.163 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.914902e-01 0.407 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 4.593326e-01 0.338 0 0
Cellular responses to stimuli R-HSA-8953897 2.814725e-01 0.551 0 0
Metabolism of RNA R-HSA-8953854 1.932384e-01 0.714 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.450664e-01 0.352 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.450664e-01 0.352 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.931090e-01 0.227 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.996690e-01 0.222 0 0
HIV Life Cycle R-HSA-162587 2.030085e-01 0.692 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.614919e-01 0.336 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.683169e-01 0.571 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.813931e-01 0.318 0 0
HDMs demethylate histones R-HSA-3214842 3.727417e-01 0.429 0 0
Collagen degradation R-HSA-1442490 5.341827e-01 0.272 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.808155e-01 0.743 0 0
NGF-stimulated transcription R-HSA-9031628 3.025669e-01 0.519 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.278693e-01 0.642 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.215294e-01 0.493 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.215294e-01 0.493 0 0
Mitochondrial transcription initiation R-HSA-163282 3.215294e-01 0.493 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.038333e-01 0.394 0 0
C6 deamination of adenosine R-HSA-75102 4.038333e-01 0.394 0 0
TGFBR3 regulates activin signaling R-HSA-9839406 4.038333e-01 0.394 0 0
Ionotropic activity of kainate receptors R-HSA-451306 2.720622e-01 0.565 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.331118e-01 0.632 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.761573e-01 0.322 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.468789e-01 0.460 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.397110e-01 0.268 0 0
Signalling to RAS R-HSA-167044 4.332958e-01 0.363 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.955574e-01 0.225 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.955574e-01 0.225 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.033062e-01 0.298 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.710563e-01 0.243 0 0
Cilium Assembly R-HSA-5617833 5.278043e-01 0.278 0 0
Regulation of IFNG signaling R-HSA-877312 6.124043e-01 0.213 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.450905e-01 0.190 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.450905e-01 0.190 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.864648e-01 0.163 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.877526e-01 0.163 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 6.877526e-01 0.163 0 0
HIV Infection R-HSA-162906 5.904592e-01 0.229 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 6.972750e-01 0.157 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.112274e-01 0.386 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.161024e-01 0.665 0 0
Regulation of beta-cell development R-HSA-186712 3.681416e-01 0.434 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.599482e-01 0.337 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.460648e-01 0.263 0 0
RMTs methylate histone arginines R-HSA-3214858 2.353438e-01 0.628 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.330159e-01 0.363 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.330159e-01 0.363 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.412075e-01 0.267 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.412075e-01 0.267 0 0
FLT3 signaling in disease R-HSA-9682385 6.520104e-01 0.186 0 0
FLT3 Signaling R-HSA-9607240 4.268042e-01 0.370 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.530118e-01 0.185 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.530118e-01 0.185 0 0
Cell junction organization R-HSA-446728 4.914505e-01 0.309 0 0
Long-term potentiation R-HSA-9620244 3.727417e-01 0.429 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.914902e-01 0.407 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.390859e-01 0.268 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.191072e-01 0.208 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.103005e-01 0.292 0 0
Cell-Cell communication R-HSA-1500931 3.678846e-01 0.434 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.664653e-01 0.574 0 0
Adherens junctions interactions R-HSA-418990 5.803710e-01 0.236 0 0
Reproduction R-HSA-1474165 6.116773e-01 0.213 0 0
Signaling by NTRKs R-HSA-166520 1.879978e-01 0.726 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.168555e-01 0.287 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.158631e-01 0.381 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.446309e-01 0.191 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.446309e-01 0.191 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.755539e-01 0.170 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.219561e-01 0.492 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.512804e-01 0.259 0 0
Signaling by TGFBR3 R-HSA-9839373 1.673216e-01 0.776 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.448236e-01 0.191 0 0
MHC class II antigen presentation R-HSA-2132295 5.045927e-01 0.297 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.682949e-01 0.245 0 0
Regulation of KIT signaling R-HSA-1433559 4.112274e-01 0.386 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.363169e-01 0.360 0 0
Base Excision Repair R-HSA-73884 4.049079e-01 0.393 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.996538e-01 0.155 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.438731e-01 0.613 0 0
Signal transduction by L1 R-HSA-445144 4.047070e-01 0.393 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.412075e-01 0.267 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.012992e-01 0.521 0 0
Kinesins R-HSA-983189 5.168555e-01 0.287 0 0
Recycling pathway of L1 R-HSA-437239 5.669866e-01 0.246 0 0
TBC/RABGAPs R-HSA-8854214 6.448236e-01 0.191 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.541863e-01 0.812 0 0
Host Interactions of HIV factors R-HSA-162909 5.168811e-01 0.287 0 0
Gene Silencing by RNA R-HSA-211000 3.731201e-01 0.428 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.765255e-01 0.424 0 0
MAP kinase activation R-HSA-450294 6.672849e-01 0.176 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.286306e-01 0.277 0 0
Interleukin-17 signaling R-HSA-448424 6.772108e-01 0.169 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.231632e-01 0.373 0 0
PI Metabolism R-HSA-1483255 5.991426e-01 0.222 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.215294e-01 0.493 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.215294e-01 0.493 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.293580e-01 0.639 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.038333e-01 0.394 0 0
SLC-mediated bile acid transport R-HSA-9958517 4.158631e-01 0.381 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.889878e-01 0.724 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.112274e-01 0.386 0 0
ARMS-mediated activation R-HSA-170984 4.593326e-01 0.338 0 0
Sensory perception of sour taste R-HSA-9729555 5.397110e-01 0.268 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.008558e-01 0.300 0 0
Utilization of Ketone Bodies R-HSA-77108 5.402651e-01 0.267 0 0
Pyrophosphate hydrolysis R-HSA-71737 5.955574e-01 0.225 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.774624e-01 0.238 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.710563e-01 0.243 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.530118e-01 0.185 0 0
Post NMDA receptor activation events R-HSA-438064 6.951463e-01 0.158 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.755539e-01 0.170 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.877526e-01 0.163 0 0
Synthesis of dolichyl-phosphate-glucose R-HSA-480985 6.877526e-01 0.163 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.891817e-01 0.311 0 0
Semaphorin interactions R-HSA-373755 5.681234e-01 0.246 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.973641e-01 0.527 0 0
Signaling by ALK R-HSA-201556 2.486137e-01 0.604 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.943613e-01 0.711 0 0
Nephrin family interactions R-HSA-373753 4.047070e-01 0.393 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.068826e-01 0.217 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.591846e-01 0.798 0 0
Basigin interactions R-HSA-210991 2.486139e-01 0.604 0 0
Signaling by Hippo R-HSA-2028269 3.179402e-01 0.498 0 0
Signal regulatory protein family interactions R-HSA-391160 4.112274e-01 0.386 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.150434e-01 0.382 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.608485e-01 0.251 0 0
Interleukin-37 signaling R-HSA-9008059 1.890411e-01 0.723 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.951810e-01 0.403 0 0
PECAM1 interactions R-HSA-210990 5.402651e-01 0.267 0 0
Suppression of apoptosis R-HSA-9635465 5.402651e-01 0.267 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.755539e-01 0.170 0 0
Signaling by PTK6 R-HSA-8848021 4.363169e-01 0.360 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.363169e-01 0.360 0 0
L1CAM interactions R-HSA-373760 4.174263e-01 0.379 0 0
Ketone body metabolism R-HSA-74182 5.162664e-01 0.287 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.168555e-01 0.287 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.078429e-01 0.682 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.119238e-01 0.674 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.377291e-01 0.624 0 0
Inositol phosphate metabolism R-HSA-1483249 3.433237e-01 0.464 0 0
NrCAM interactions R-HSA-447038 2.293580e-01 0.639 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.608680e-01 0.584 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.707011e-01 0.431 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.761573e-01 0.322 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.593326e-01 0.338 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.614919e-01 0.336 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.614919e-01 0.336 0 0
Collagen chain trimerization R-HSA-8948216 5.033062e-01 0.298 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.124043e-01 0.213 0 0
CREB phosphorylation R-HSA-199920 6.877526e-01 0.163 0 0
NADPH regeneration R-HSA-389542 6.877526e-01 0.163 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.109180e-01 0.214 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.301396e-01 0.201 0 0
Sensory processing of sound R-HSA-9659379 5.698092e-01 0.244 0 0
Amino acid transport across the plasma membrane R-HSA-352230 6.355754e-01 0.197 0 0
Maturation of nucleoprotein R-HSA-9683610 3.767714e-01 0.424 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.124043e-01 0.213 0 0
Specification of primordial germ cells R-HSA-9827857 3.179402e-01 0.498 0 0
Programmed Cell Death R-HSA-5357801 2.022637e-01 0.694 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 5.955574e-01 0.225 0 0
Signaling by LTK R-HSA-9842663 6.124043e-01 0.213 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.446309e-01 0.191 0 0
HDL clearance R-HSA-8964011 6.877526e-01 0.163 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.565523e-01 0.183 0 0
tRNA processing R-HSA-72306 6.426613e-01 0.192 0 0
Physiological factors R-HSA-5578768 2.061423e-01 0.686 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.101923e-01 0.292 0 0
Acyl chain remodeling of CL R-HSA-1482798 6.755539e-01 0.170 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.955574e-01 0.225 0 0
Maturation of nucleoprotein R-HSA-9694631 5.996690e-01 0.222 0 0
Glycolysis R-HSA-70171 6.759977e-01 0.170 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.895521e-01 0.161 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.955574e-01 0.225 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.755539e-01 0.170 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.565523e-01 0.183 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.776991e-01 0.169 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.450905e-01 0.190 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.755539e-01 0.170 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.710563e-01 0.243 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.010602e-01 0.154 0 0
Cargo concentration in the ER R-HSA-5694530 7.036228e-01 0.153 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.036228e-01 0.153 0 0
Budding and maturation of HIV virion R-HSA-162588 7.036228e-01 0.153 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.038526e-01 0.153 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.038526e-01 0.153 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.038526e-01 0.153 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.038526e-01 0.153 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.038526e-01 0.153 0 0
Signaling by Activin R-HSA-1502540 7.038526e-01 0.153 0 0
p75NTR signals via NF-kB R-HSA-193639 7.038526e-01 0.153 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.038526e-01 0.153 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 7.038526e-01 0.153 0 0
Protein methylation R-HSA-8876725 7.038526e-01 0.153 0 0
Other semaphorin interactions R-HSA-416700 7.038526e-01 0.153 0 0
Formation of the anterior neural plate R-HSA-9823739 7.038526e-01 0.153 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.051045e-01 0.152 0 0
Insulin receptor signalling cascade R-HSA-74751 7.116024e-01 0.148 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.137016e-01 0.146 0 0
Signaling by WNT in cancer R-HSA-4791275 7.228945e-01 0.141 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.231076e-01 0.141 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.231076e-01 0.141 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.231076e-01 0.141 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 7.231076e-01 0.141 0 0
Carnitine shuttle R-HSA-200425 7.231076e-01 0.141 0 0
Formation of the ureteric bud R-HSA-9830674 7.231076e-01 0.141 0 0
Growth hormone receptor signaling R-HSA-982772 7.231076e-01 0.141 0 0
Syndecan interactions R-HSA-3000170 7.231076e-01 0.141 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.238419e-01 0.140 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.254765e-01 0.139 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.254819e-01 0.139 0 0
Aggrephagy R-HSA-9646399 7.254819e-01 0.139 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 7.254819e-01 0.139 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.256439e-01 0.139 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.256439e-01 0.139 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.256439e-01 0.139 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.256439e-01 0.139 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.256439e-01 0.139 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.256439e-01 0.139 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.256439e-01 0.139 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.256439e-01 0.139 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.256439e-01 0.139 0 0
VLDL clearance R-HSA-8964046 7.256439e-01 0.139 0 0
Regulation of PTEN localization R-HSA-8948747 7.256439e-01 0.139 0 0
Netrin mediated repulsion signals R-HSA-418886 7.256439e-01 0.139 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.256439e-01 0.139 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.256439e-01 0.139 0 0
CHL1 interactions R-HSA-447041 7.256439e-01 0.139 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.265613e-01 0.139 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.300633e-01 0.137 0 0
Regulation of BACH1 activity R-HSA-9708530 7.300633e-01 0.137 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.300633e-01 0.137 0 0
Negative regulation of FLT3 R-HSA-9706369 7.300633e-01 0.137 0 0
Differentiation of T cells R-HSA-9945266 7.300633e-01 0.137 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.300633e-01 0.137 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 7.300633e-01 0.137 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 7.300633e-01 0.137 0 0
Signaling by FGFR in disease R-HSA-1226099 7.314077e-01 0.136 0 0
Signaling by ERBB4 R-HSA-1236394 7.314077e-01 0.136 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.331177e-01 0.135 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.331177e-01 0.135 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.372580e-01 0.132 0 0
Neddylation R-HSA-8951664 7.402175e-01 0.131 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.412192e-01 0.130 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.412192e-01 0.130 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.424664e-01 0.129 0 0
PIP3 activates AKT signaling R-HSA-1257604 7.437392e-01 0.129 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.438639e-01 0.129 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 7.438639e-01 0.129 0 0
Protein ubiquitination R-HSA-8852135 7.439523e-01 0.128 0 0
Gap junction trafficking and regulation R-HSA-157858 7.444793e-01 0.128 0 0
Dual incision in TC-NER R-HSA-6782135 7.479047e-01 0.126 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.495075e-01 0.125 0 0
SLC-mediated transport of amino acids R-HSA-9958863 7.518523e-01 0.124 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.542760e-01 0.122 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.542760e-01 0.122 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.542760e-01 0.122 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.542760e-01 0.122 0 0
UCH proteinases R-HSA-5689603 7.560896e-01 0.121 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.577518e-01 0.120 0 0
HIV Transcription Initiation R-HSA-167161 7.577518e-01 0.120 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.577518e-01 0.120 0 0
Striated Muscle Contraction R-HSA-390522 7.586082e-01 0.120 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.586082e-01 0.120 0 0
phospho-PLA2 pathway R-HSA-111995 7.589390e-01 0.120 0 0
MET receptor recycling R-HSA-8875656 7.589390e-01 0.120 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.589390e-01 0.120 0 0
Activation of RAS in B cells R-HSA-1169092 7.589390e-01 0.120 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.589390e-01 0.120 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.589390e-01 0.120 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.589390e-01 0.120 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.589390e-01 0.120 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.589390e-01 0.120 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.589390e-01 0.120 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.589390e-01 0.120 0 0
RSK activation R-HSA-444257 7.589390e-01 0.120 0 0
Sodium/Proton exchangers R-HSA-425986 7.589390e-01 0.120 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.589390e-01 0.120 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.589390e-01 0.120 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.624041e-01 0.118 0 0
Laminin interactions R-HSA-3000157 7.633595e-01 0.117 0 0
Transcription of the HIV genome R-HSA-167172 7.643518e-01 0.117 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 7.643518e-01 0.117 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 7.646140e-01 0.117 0 0
Ca-dependent events R-HSA-111996 7.727808e-01 0.112 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.727808e-01 0.112 0 0
Depyrimidination R-HSA-73928 7.727808e-01 0.112 0 0
Meiotic recombination R-HSA-912446 7.727989e-01 0.112 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.750773e-01 0.111 0 0
Signaling by NOTCH2 R-HSA-1980145 7.750773e-01 0.111 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.750773e-01 0.111 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.750773e-01 0.111 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.765895e-01 0.110 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.765895e-01 0.110 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.765895e-01 0.110 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.765895e-01 0.110 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.765895e-01 0.110 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.765895e-01 0.110 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.765895e-01 0.110 0 0
Cell-cell junction organization R-HSA-421270 7.770869e-01 0.110 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.782187e-01 0.109 0 0
MET activates PTK2 signaling R-HSA-8874081 7.816316e-01 0.107 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.816316e-01 0.107 0 0
Metalloprotease DUBs R-HSA-5689901 7.816316e-01 0.107 0 0
TRP channels R-HSA-3295583 7.816316e-01 0.107 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.822309e-01 0.107 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.860483e-01 0.105 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.870858e-01 0.104 0 0
COPII-mediated vesicle transport R-HSA-204005 7.879810e-01 0.103 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.881953e-01 0.103 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 7.881953e-01 0.103 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.881953e-01 0.103 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.881953e-01 0.103 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.881953e-01 0.103 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.881953e-01 0.103 0 0
Unwinding of DNA R-HSA-176974 7.881953e-01 0.103 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.881953e-01 0.103 0 0
mRNA Editing R-HSA-75072 7.881953e-01 0.103 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.881953e-01 0.103 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.881953e-01 0.103 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.881953e-01 0.103 0 0
Degradation of GABA R-HSA-916853 7.881953e-01 0.103 0 0
WNT mediated activation of DVL R-HSA-201688 7.881953e-01 0.103 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.881953e-01 0.103 0 0
Lipophagy R-HSA-9613354 7.881953e-01 0.103 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.881953e-01 0.103 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.881953e-01 0.103 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.881953e-01 0.103 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.881953e-01 0.103 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.881953e-01 0.103 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.906465e-01 0.102 0 0
GAB1 signalosome R-HSA-180292 7.971081e-01 0.098 0 0
PKA activation in glucagon signalling R-HSA-164378 7.971081e-01 0.098 0 0
Ephrin signaling R-HSA-3928664 7.971081e-01 0.098 0 0
Tie2 Signaling R-HSA-210993 7.971081e-01 0.098 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.971081e-01 0.098 0 0
Nephron development R-HSA-9831926 7.971081e-01 0.098 0 0
Signaling by PDGF R-HSA-186797 7.983744e-01 0.098 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.987012e-01 0.098 0 0
Smooth Muscle Contraction R-HSA-445355 7.987012e-01 0.098 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.987223e-01 0.098 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.987223e-01 0.098 0 0
Packaging Of Telomere Ends R-HSA-171306 7.987223e-01 0.098 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.987223e-01 0.098 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.987223e-01 0.098 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.987223e-01 0.098 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 7.991175e-01 0.097 0 0
PKR-mediated signaling R-HSA-9833482 8.005769e-01 0.097 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.006803e-01 0.097 0 0
Netrin-1 signaling R-HSA-373752 8.006803e-01 0.097 0 0
Diseases of programmed cell death R-HSA-9645723 8.025263e-01 0.096 0 0
HSF1 activation R-HSA-3371511 8.053394e-01 0.094 0 0
Calmodulin induced events R-HSA-111933 8.053394e-01 0.094 0 0
CaM pathway R-HSA-111997 8.053394e-01 0.094 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.073398e-01 0.093 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.097100e-01 0.092 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.135799e-01 0.090 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.139023e-01 0.089 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.139023e-01 0.089 0 0
DNA replication initiation R-HSA-68952 8.139023e-01 0.089 0 0
Pexophagy R-HSA-9664873 8.139023e-01 0.089 0 0
PI3K/AKT activation R-HSA-198203 8.139023e-01 0.089 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.139023e-01 0.089 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.139023e-01 0.089 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.139023e-01 0.089 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.139023e-01 0.089 0 0
Arachidonate production from DAG R-HSA-426048 8.139023e-01 0.089 0 0
2-LTR circle formation R-HSA-164843 8.139023e-01 0.089 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.139023e-01 0.089 0 0
Sperm Motility And Taxes R-HSA-1300642 8.139023e-01 0.089 0 0
Formation of apoptosome R-HSA-111458 8.139023e-01 0.089 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.139023e-01 0.089 0 0
Signaling by Leptin R-HSA-2586552 8.139023e-01 0.089 0 0
Telomere Extension By Telomerase R-HSA-171319 8.146775e-01 0.089 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.146775e-01 0.089 0 0
Pyrimidine salvage R-HSA-73614 8.146775e-01 0.089 0 0
Regulation of signaling by CBL R-HSA-912631 8.159387e-01 0.088 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.159387e-01 0.088 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.159387e-01 0.088 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.159387e-01 0.088 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.174981e-01 0.088 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.191820e-01 0.087 0 0
Metabolism of folate and pterines R-HSA-196757 8.191820e-01 0.087 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.200606e-01 0.086 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.236794e-01 0.084 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 8.245035e-01 0.084 0 0
Cellular response to chemical stress R-HSA-9711123 8.281099e-01 0.082 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.285726e-01 0.082 0 0
DNA methylation R-HSA-5334118 8.295460e-01 0.081 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.295460e-01 0.081 0 0
mRNA Capping R-HSA-72086 8.295460e-01 0.081 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.295460e-01 0.081 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.295460e-01 0.081 0 0
Late endosomal microautophagy R-HSA-9615710 8.295460e-01 0.081 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.295460e-01 0.081 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.331887e-01 0.079 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.331887e-01 0.079 0 0
Formation of definitive endoderm R-HSA-9823730 8.331887e-01 0.079 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.331887e-01 0.079 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.331887e-01 0.079 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.331887e-01 0.079 0 0
Synthesis of Ketone Bodies R-HSA-77111 8.331887e-01 0.079 0 0
Signaling by FGFR1 R-HSA-5654736 8.331919e-01 0.079 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.331919e-01 0.079 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.364906e-01 0.078 0 0
Signaling by APC mutants R-HSA-4839744 8.364906e-01 0.078 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 8.364906e-01 0.078 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 8.364906e-01 0.078 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 8.364906e-01 0.078 0 0
LGI-ADAM interactions R-HSA-5682910 8.364906e-01 0.078 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.364906e-01 0.078 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 8.364906e-01 0.078 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.364906e-01 0.078 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.364906e-01 0.078 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.364906e-01 0.078 0 0
Chylomicron assembly R-HSA-8963888 8.364906e-01 0.078 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.364906e-01 0.078 0 0
IRE1alpha activates chaperones R-HSA-381070 8.388491e-01 0.076 0 0
Signal Transduction R-HSA-162582 8.391116e-01 0.076 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.433786e-01 0.074 0 0
Stabilization of p53 R-HSA-69541 8.444320e-01 0.073 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.444320e-01 0.073 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.480560e-01 0.072 0 0
Stimuli-sensing channels R-HSA-2672351 8.480560e-01 0.072 0 0
Interleukin-12 signaling R-HSA-9020591 8.482600e-01 0.071 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 8.489644e-01 0.071 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.489644e-01 0.071 0 0
ERK/MAPK targets R-HSA-198753 8.489644e-01 0.071 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.489644e-01 0.071 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.492828e-01 0.071 0 0
Kidney development R-HSA-9830369 8.501748e-01 0.070 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.506951e-01 0.070 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.534301e-01 0.069 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.547981e-01 0.068 0 0
Vesicle-mediated transport R-HSA-5653656 8.558435e-01 0.068 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.559009e-01 0.068 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.559009e-01 0.068 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.559009e-01 0.068 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.562267e-01 0.067 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.562267e-01 0.067 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.562267e-01 0.067 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.563383e-01 0.067 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.563383e-01 0.067 0 0
Signaling by GSK3beta mutants R-HSA-5339716 8.563383e-01 0.067 0 0
Integration of provirus R-HSA-162592 8.563383e-01 0.067 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.563383e-01 0.067 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.563383e-01 0.067 0 0
NF-kB is activated and signals survival R-HSA-209560 8.563383e-01 0.067 0 0
ERKs are inactivated R-HSA-202670 8.563383e-01 0.067 0 0
Signaling by AXIN mutants R-HSA-4839735 8.563383e-01 0.067 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.563383e-01 0.067 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.563383e-01 0.067 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.563383e-01 0.067 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 8.563383e-01 0.067 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.568373e-01 0.067 0 0
Degradation of CDH1 R-HSA-9766229 8.586053e-01 0.066 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 8.623460e-01 0.064 0 0
MyD88-independent TLR4 cascade R-HSA-166166 8.623460e-01 0.064 0 0
Glucose metabolism R-HSA-70326 8.628243e-01 0.064 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.633693e-01 0.064 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.633693e-01 0.064 0 0
Glutathione synthesis and recycling R-HSA-174403 8.633693e-01 0.064 0 0
Assembly Of The HIV Virion R-HSA-175474 8.633693e-01 0.064 0 0
Signaling by VEGF R-HSA-194138 8.635741e-01 0.064 0 0
Nervous system development R-HSA-9675108 8.635897e-01 0.064 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.666419e-01 0.062 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.666419e-01 0.062 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.681425e-01 0.061 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.681425e-01 0.061 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.683236e-01 0.061 0 0
Azathioprine ADME R-HSA-9748787 8.683236e-01 0.061 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.737778e-01 0.059 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.737778e-01 0.059 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.737778e-01 0.059 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.737778e-01 0.059 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.737778e-01 0.059 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.737778e-01 0.059 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.737778e-01 0.059 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.737778e-01 0.059 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 8.737778e-01 0.059 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 8.737778e-01 0.059 0 0
MET activates RAS signaling R-HSA-8851805 8.737778e-01 0.059 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.737778e-01 0.059 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.737778e-01 0.059 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.737778e-01 0.059 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.737778e-01 0.059 0 0
OAS antiviral response R-HSA-8983711 8.737778e-01 0.059 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.765038e-01 0.057 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.765038e-01 0.057 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 8.765038e-01 0.057 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.765038e-01 0.057 0 0
Signaling by KIT in disease R-HSA-9669938 8.765038e-01 0.057 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.774715e-01 0.057 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.791778e-01 0.056 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.796346e-01 0.056 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.802434e-01 0.055 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.833906e-01 0.054 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.860725e-01 0.053 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.860725e-01 0.053 0 0
Signaling by WNT R-HSA-195721 8.873851e-01 0.052 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.884640e-01 0.051 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.884640e-01 0.051 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.884640e-01 0.051 0 0
HCMV Early Events R-HSA-9609690 8.887167e-01 0.051 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.891011e-01 0.051 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.891011e-01 0.051 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.891011e-01 0.051 0 0
Chylomicron remodeling R-HSA-8963901 8.891011e-01 0.051 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.891011e-01 0.051 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.891011e-01 0.051 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.891011e-01 0.051 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.891011e-01 0.051 0 0
Interleukin-6 signaling R-HSA-1059683 8.891011e-01 0.051 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.893838e-01 0.051 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.893838e-01 0.051 0 0
Telomere Maintenance R-HSA-157579 8.896662e-01 0.051 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.901101e-01 0.051 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.906603e-01 0.050 0 0
Defective pyroptosis R-HSA-9710421 8.948249e-01 0.048 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.957171e-01 0.048 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.957171e-01 0.048 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.957171e-01 0.048 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.982469e-01 0.047 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.988106e-01 0.046 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.988106e-01 0.046 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.988106e-01 0.046 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.993413e-01 0.046 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.993413e-01 0.046 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.993413e-01 0.046 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.993413e-01 0.046 0 0
Interleukin-6 family signaling R-HSA-6783589 8.993413e-01 0.046 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.993413e-01 0.046 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.993413e-01 0.046 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.993413e-01 0.046 0 0
Axon guidance R-HSA-422475 9.003842e-01 0.046 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.017277e-01 0.045 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.025650e-01 0.045 0 0
Removal of the Flap Intermediate R-HSA-69166 9.025650e-01 0.045 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 9.025650e-01 0.045 0 0
cGMP effects R-HSA-418457 9.025650e-01 0.045 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.025650e-01 0.045 0 0
Hydrolysis of LPC R-HSA-1483115 9.025650e-01 0.045 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 9.025650e-01 0.045 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 9.025650e-01 0.045 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 9.025650e-01 0.045 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 9.025650e-01 0.045 0 0
HDL assembly R-HSA-8963896 9.025650e-01 0.045 0 0
Zinc transporters R-HSA-435354 9.025650e-01 0.045 0 0
P2Y receptors R-HSA-417957 9.025650e-01 0.045 0 0
PTEN Regulation R-HSA-6807070 9.026443e-01 0.044 0 0
Gap junction trafficking R-HSA-190828 9.029819e-01 0.044 0 0
Amine ligand-binding receptors R-HSA-375280 9.029819e-01 0.044 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.064428e-01 0.043 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.071734e-01 0.042 0 0
HCMV Late Events R-HSA-9610379 9.072388e-01 0.042 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.075071e-01 0.042 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.075071e-01 0.042 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.075071e-01 0.042 0 0
Cellular response to hypoxia R-HSA-1234174 9.089533e-01 0.041 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.092224e-01 0.041 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.092224e-01 0.041 0 0
Formation of the nephric duct R-HSA-9830364 9.092224e-01 0.041 0 0
Sema4D in semaphorin signaling R-HSA-400685 9.092224e-01 0.041 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.092224e-01 0.041 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.092224e-01 0.041 0 0
Interleukin-7 signaling R-HSA-1266695 9.092224e-01 0.041 0 0
Signaling by Insulin receptor R-HSA-74752 9.092265e-01 0.041 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.105742e-01 0.041 0 0
DAG and IP3 signaling R-HSA-1489509 9.105742e-01 0.041 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 9.143950e-01 0.039 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.143950e-01 0.039 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 9.143950e-01 0.039 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.143950e-01 0.039 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.143950e-01 0.039 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 9.143950e-01 0.039 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 9.143950e-01 0.039 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.143950e-01 0.039 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.143950e-01 0.039 0 0
DNA Damage Reversal R-HSA-73942 9.143950e-01 0.039 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.151761e-01 0.038 0 0
GPVI-mediated activation cascade R-HSA-114604 9.155205e-01 0.038 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.176329e-01 0.037 0 0
Myogenesis R-HSA-525793 9.181887e-01 0.037 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.181887e-01 0.037 0 0
Urea cycle R-HSA-70635 9.181887e-01 0.037 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.196482e-01 0.036 0 0
Regulation of CDH1 Function R-HSA-9764561 9.216932e-01 0.035 0 0
Cleavage of the damaged purine R-HSA-110331 9.228961e-01 0.035 0 0
SARS-CoV Infections R-HSA-9679506 9.240932e-01 0.034 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.241888e-01 0.034 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.247892e-01 0.034 0 0
Activation of SMO R-HSA-5635838 9.247892e-01 0.034 0 0
Attachment and Entry R-HSA-9678110 9.247892e-01 0.034 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.247892e-01 0.034 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 9.263166e-01 0.033 0 0
Cristae formation R-HSA-8949613 9.263166e-01 0.033 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.263166e-01 0.033 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 9.263166e-01 0.033 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.263166e-01 0.033 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.264927e-01 0.033 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.266412e-01 0.033 0 0
Interleukin-12 family signaling R-HSA-447115 9.276062e-01 0.033 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.290286e-01 0.032 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.296775e-01 0.032 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.296775e-01 0.032 0 0
Depurination R-HSA-73927 9.296775e-01 0.032 0 0
Co-stimulation by CD28 R-HSA-389356 9.302713e-01 0.031 0 0
GPER1 signaling R-HSA-9634597 9.302713e-01 0.031 0 0
RSV-host interactions R-HSA-9833110 9.307811e-01 0.031 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.334517e-01 0.030 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.336776e-01 0.030 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.336776e-01 0.030 0 0
HIV elongation arrest and recovery R-HSA-167287 9.336776e-01 0.030 0 0
Pausing and recovery of HIV elongation R-HSA-167290 9.336776e-01 0.030 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.336776e-01 0.030 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.336776e-01 0.030 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.336776e-01 0.030 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.339219e-01 0.030 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.339219e-01 0.030 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.339219e-01 0.030 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.339219e-01 0.030 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 9.339219e-01 0.030 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.339219e-01 0.030 0 0
Synthesis of PG R-HSA-1483148 9.339219e-01 0.030 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.339219e-01 0.030 0 0
Coenzyme A biosynthesis R-HSA-196783 9.339219e-01 0.030 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.339219e-01 0.030 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.359062e-01 0.029 0 0
Glutathione conjugation R-HSA-156590 9.379794e-01 0.028 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.402227e-01 0.027 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.403379e-01 0.027 0 0
Platelet calcium homeostasis R-HSA-418360 9.403379e-01 0.027 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.416217e-01 0.026 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.416217e-01 0.026 0 0
HIV Transcription Elongation R-HSA-167169 9.416217e-01 0.026 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.419461e-01 0.026 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.419461e-01 0.026 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.419461e-01 0.026 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.426904e-01 0.026 0 0
PLC beta mediated events R-HSA-112043 9.426904e-01 0.026 0 0
Signaling by ROBO receptors R-HSA-376176 9.443244e-01 0.025 0 0
Gastrulation R-HSA-9758941 9.444628e-01 0.025 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.452630e-01 0.024 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.458445e-01 0.024 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.463593e-01 0.024 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.463593e-01 0.024 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.463593e-01 0.024 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.463593e-01 0.024 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.468614e-01 0.024 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.470760e-01 0.024 0 0
Potential therapeutics for SARS R-HSA-9679191 9.473537e-01 0.023 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.489963e-01 0.023 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.489963e-01 0.023 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.489963e-01 0.023 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.489963e-01 0.023 0 0
Platelet sensitization by LDL R-HSA-432142 9.489963e-01 0.023 0 0
Apoptotic factor-mediated response R-HSA-111471 9.489963e-01 0.023 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.489963e-01 0.023 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.489963e-01 0.023 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.491290e-01 0.023 0 0
Ca2+ pathway R-HSA-4086398 9.492233e-01 0.023 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.504248e-01 0.022 0 0
HCMV Infection R-HSA-9609646 9.512677e-01 0.022 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.515395e-01 0.022 0 0
Intra-Golgi traffic R-HSA-6811438 9.516606e-01 0.022 0 0
Translation of Structural Proteins R-HSA-9683701 9.516606e-01 0.022 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.517985e-01 0.021 0 0
Trafficking of AMPA receptors R-HSA-399719 9.517985e-01 0.021 0 0
Influenza Infection R-HSA-168255 9.528990e-01 0.021 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.551907e-01 0.020 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.551907e-01 0.020 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.551907e-01 0.020 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.551907e-01 0.020 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.551907e-01 0.020 0 0
Diseases of hemostasis R-HSA-9671793 9.551907e-01 0.020 0 0
Other interleukin signaling R-HSA-449836 9.551907e-01 0.020 0 0
Methionine salvage pathway R-HSA-1237112 9.551907e-01 0.020 0 0
HDL remodeling R-HSA-8964058 9.551907e-01 0.020 0 0
The NLRP3 inflammasome R-HSA-844456 9.551907e-01 0.020 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.558338e-01 0.020 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.558338e-01 0.020 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.560525e-01 0.020 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.563793e-01 0.019 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.567081e-01 0.019 0 0
Co-inhibition by PD-1 R-HSA-389948 9.585453e-01 0.018 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.604266e-01 0.018 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.605771e-01 0.017 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.606331e-01 0.017 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.606331e-01 0.017 0 0
Co-inhibition by CTLA4 R-HSA-389513 9.606331e-01 0.017 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.611366e-01 0.017 0 0
Recycling of bile acids and salts R-HSA-159418 9.611366e-01 0.017 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.611366e-01 0.017 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.633646e-01 0.016 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.633646e-01 0.016 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.637376e-01 0.016 0 0
G-protein mediated events R-HSA-112040 9.647647e-01 0.016 0 0
Ion homeostasis R-HSA-5578775 9.650944e-01 0.015 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.650944e-01 0.015 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.651283e-01 0.015 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.651283e-01 0.015 0 0
Heme degradation R-HSA-189483 9.651283e-01 0.015 0 0
Integrin cell surface interactions R-HSA-216083 9.654090e-01 0.015 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.654147e-01 0.015 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.654147e-01 0.015 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.654147e-01 0.015 0 0
Peptide chain elongation R-HSA-156902 9.666214e-01 0.015 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.670875e-01 0.015 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.687241e-01 0.014 0 0
Signal amplification R-HSA-392518 9.687241e-01 0.014 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.696158e-01 0.013 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.696158e-01 0.013 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.696158e-01 0.013 0 0
Attachment and Entry R-HSA-9694614 9.696158e-01 0.013 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.701713e-01 0.013 0 0
Signaling by FGFR2 R-HSA-5654738 9.704419e-01 0.013 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.719610e-01 0.012 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.719610e-01 0.012 0 0
PERK regulates gene expression R-HSA-381042 9.719610e-01 0.012 0 0
Interleukin-1 family signaling R-HSA-446652 9.725617e-01 0.012 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.725764e-01 0.012 0 0
Synthesis of PC R-HSA-1483191 9.729297e-01 0.012 0 0
LDL clearance R-HSA-8964038 9.733068e-01 0.012 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.733588e-01 0.012 0 0
Signaling by Interleukins R-HSA-449147 9.744847e-01 0.011 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.748734e-01 0.011 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.748734e-01 0.011 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.753111e-01 0.011 0 0
Metal ion SLC transporters R-HSA-425410 9.754679e-01 0.011 0 0
RAB geranylgeranylation R-HSA-8873719 9.756376e-01 0.011 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.756376e-01 0.011 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.765496e-01 0.010 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.765496e-01 0.010 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.765496e-01 0.010 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.765496e-01 0.010 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.765496e-01 0.010 0 0
Interleukin-20 family signaling R-HSA-8854691 9.765496e-01 0.010 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.769735e-01 0.010 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.774921e-01 0.010 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.774921e-01 0.010 0 0
Degradation of DVL R-HSA-4641258 9.774921e-01 0.010 0 0
NCAM1 interactions R-HSA-419037 9.774921e-01 0.010 0 0
Aquaporin-mediated transport R-HSA-445717 9.777605e-01 0.010 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.781213e-01 0.010 0 0
Phospholipid metabolism R-HSA-1483257 9.781656e-01 0.010 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.787606e-01 0.009 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.787606e-01 0.009 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.793986e-01 0.009 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 9.793986e-01 0.009 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.793986e-01 0.009 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 9.793986e-01 0.009 0 0
Ribosome-associated quality control R-HSA-9948299 9.794866e-01 0.009 0 0
Elastic fibre formation R-HSA-1566948 9.798457e-01 0.009 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.798457e-01 0.009 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.798813e-01 0.009 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.807739e-01 0.008 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.817932e-01 0.008 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.818734e-01 0.008 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.819017e-01 0.008 0 0
Tight junction interactions R-HSA-420029 9.819017e-01 0.008 0 0
Hyaluronan degradation R-HSA-2160916 9.819017e-01 0.008 0 0
Fertilization R-HSA-1187000 9.819017e-01 0.008 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.819597e-01 0.008 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.831308e-01 0.007 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.832394e-01 0.007 0 0
Generation of second messenger molecules R-HSA-202433 9.838578e-01 0.007 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.840709e-01 0.007 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.841007e-01 0.007 0 0
Sphingolipid catabolism R-HSA-9845614 9.841007e-01 0.007 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.841007e-01 0.007 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.841007e-01 0.007 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.847563e-01 0.007 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.851085e-01 0.007 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.851085e-01 0.007 0 0
Toll-like Receptor Cascades R-HSA-168898 9.855301e-01 0.006 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.855610e-01 0.006 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.855610e-01 0.006 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.855610e-01 0.006 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.858716e-01 0.006 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.860327e-01 0.006 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.860327e-01 0.006 0 0
Signaling by BMP R-HSA-201451 9.860327e-01 0.006 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.860327e-01 0.006 0 0
Synthesis of PE R-HSA-1483213 9.860327e-01 0.006 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.860327e-01 0.006 0 0
Insulin processing R-HSA-264876 9.860327e-01 0.006 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.860327e-01 0.006 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.862437e-01 0.006 0 0
Translation initiation complex formation R-HSA-72649 9.865409e-01 0.006 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.865409e-01 0.006 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.869110e-01 0.006 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.869110e-01 0.006 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.870888e-01 0.006 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.870888e-01 0.006 0 0
Insulin receptor recycling R-HSA-77387 9.877300e-01 0.005 0 0
Pyroptosis R-HSA-5620971 9.877300e-01 0.005 0 0
Inflammasomes R-HSA-622312 9.877300e-01 0.005 0 0
Neurotransmitter release cycle R-HSA-112310 9.879667e-01 0.005 0 0
rRNA processing R-HSA-72312 9.880213e-01 0.005 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.880501e-01 0.005 0 0
Regulated Necrosis R-HSA-5218859 9.884034e-01 0.005 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.890188e-01 0.005 0 0
SLC transporter disorders R-HSA-5619102 9.891899e-01 0.005 0 0
DARPP-32 events R-HSA-180024 9.892211e-01 0.005 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.892211e-01 0.005 0 0
Interferon Signaling R-HSA-913531 9.894320e-01 0.005 0 0
Interleukin-1 signaling R-HSA-9020702 9.896172e-01 0.005 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.896863e-01 0.005 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.896863e-01 0.005 0 0
Synthesis of PA R-HSA-1483166 9.900868e-01 0.004 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.904091e-01 0.004 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 9.904091e-01 0.004 0 0
DAP12 signaling R-HSA-2424491 9.905311e-01 0.004 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.905311e-01 0.004 0 0
Neurotransmitter clearance R-HSA-112311 9.905311e-01 0.004 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.906675e-01 0.004 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.910543e-01 0.004 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.916820e-01 0.004 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.916820e-01 0.004 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.917711e-01 0.004 0 0
Somitogenesis R-HSA-9824272 9.917711e-01 0.004 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.917711e-01 0.004 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.920099e-01 0.003 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.926528e-01 0.003 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.926930e-01 0.003 0 0
DAG1 glycosylations R-HSA-8931838 9.926930e-01 0.003 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.927876e-01 0.003 0 0
Muscle contraction R-HSA-397014 9.930312e-01 0.003 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.932877e-01 0.003 0 0
Eukaryotic Translation Termination R-HSA-72764 9.933863e-01 0.003 0 0
Nucleotide salvage R-HSA-8956321 9.934402e-01 0.003 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.934418e-01 0.003 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.934704e-01 0.003 0 0
G-protein beta:gamma signalling R-HSA-397795 9.935812e-01 0.003 0 0
Platelet homeostasis R-HSA-418346 9.936583e-01 0.003 0 0
Potassium Channels R-HSA-1296071 9.939375e-01 0.003 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.940306e-01 0.003 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.940306e-01 0.003 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.941476e-01 0.003 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.943615e-01 0.002 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.943615e-01 0.002 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.943615e-01 0.002 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.947787e-01 0.002 0 0
Signaling by FGFR R-HSA-190236 9.949115e-01 0.002 0 0
Regulation of insulin secretion R-HSA-422356 9.949115e-01 0.002 0 0
eNOS activation R-HSA-203615 9.950470e-01 0.002 0 0
Gap junction assembly R-HSA-190861 9.950470e-01 0.002 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.950470e-01 0.002 0 0
Hyaluronan metabolism R-HSA-2142845 9.950470e-01 0.002 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.950470e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.950470e-01 0.002 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.950470e-01 0.002 0 0
Cellular response to starvation R-HSA-9711097 9.951114e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9694635 9.951249e-01 0.002 0 0
Interleukin-10 signaling R-HSA-6783783 9.955804e-01 0.002 0 0
Regulation of Apoptosis R-HSA-169911 9.956492e-01 0.002 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.956492e-01 0.002 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.960973e-01 0.002 0 0
Selenocysteine synthesis R-HSA-2408557 9.960973e-01 0.002 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.961782e-01 0.002 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.965411e-01 0.002 0 0
Degradation of AXIN R-HSA-4641257 9.966429e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.966429e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.966429e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.967002e-01 0.001 0 0
Viral mRNA Translation R-HSA-192823 9.967355e-01 0.001 0 0
EPH-Ephrin signaling R-HSA-2682334 9.968019e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.968019e-01 0.001 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.970511e-01 0.001 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.970511e-01 0.001 0 0
Purine salvage R-HSA-74217 9.970511e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.973068e-01 0.001 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.974097e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.974097e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.974097e-01 0.001 0 0
RAS processing R-HSA-9648002 9.974097e-01 0.001 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.974097e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.974581e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.977156e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.977156e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.977156e-01 0.001 0 0
Diseases of Immune System R-HSA-5260271 9.977247e-01 0.001 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.977247e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.977247e-01 0.001 0 0
Ion channel transport R-HSA-983712 9.977412e-01 0.001 0 0
Platelet degranulation R-HSA-114608 9.977770e-01 0.001 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.980014e-01 0.001 0 0
Maturation of spike protein R-HSA-9694548 9.980014e-01 0.001 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.980093e-01 0.001 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.981576e-01 0.001 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.982087e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.982253e-01 0.001 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.982445e-01 0.001 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.982445e-01 0.001 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.982445e-01 0.001 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.982445e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.982445e-01 0.001 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.983356e-01 0.001 0 0
Leishmania phagocytosis R-HSA-9664417 9.983356e-01 0.001 0 0
Parasite infection R-HSA-9664407 9.983356e-01 0.001 0 0
Peroxisomal protein import R-HSA-9033241 9.983528e-01 0.001 0 0
Activation of GABAB receptors R-HSA-991365 9.984580e-01 0.001 0 0
GABA B receptor activation R-HSA-977444 9.984580e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.984580e-01 0.001 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.984580e-01 0.001 0 0
Adaptive Immune System R-HSA-1280218 9.984737e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.985137e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.985339e-01 0.001 0 0
Cardiac conduction R-HSA-5576891 9.985463e-01 0.001 0 0
Pyrimidine catabolism R-HSA-73621 9.986456e-01 0.001 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.986456e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.986954e-01 0.001 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.987759e-01 0.001 0 0
DAP12 interactions R-HSA-2172127 9.988104e-01 0.001 0 0
Proteasome assembly R-HSA-9907900 9.988104e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.988104e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.988104e-01 0.001 0 0
Mitochondrial protein import R-HSA-1268020 9.988392e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.989260e-01 0.000 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.989551e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.989551e-01 0.000 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.989551e-01 0.000 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.989551e-01 0.000 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.989551e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.989674e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.990367e-01 0.000 0 0
Ion transport by P-type ATPases R-HSA-936837 9.990816e-01 0.000 0 0
Opioid Signalling R-HSA-111885 9.990817e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.990822e-01 0.000 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.990822e-01 0.000 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.990822e-01 0.000 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.990822e-01 0.000 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.991348e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.991773e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.991939e-01 0.000 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.992418e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.992819e-01 0.000 0 0
Intraflagellar transport R-HSA-5620924 9.992920e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.993545e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.993545e-01 0.000 0 0
Developmental Biology R-HSA-1266738 9.993663e-01 0.000 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.994427e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.994427e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.995203e-01 0.000 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.995203e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.995203e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.995203e-01 0.000 0 0
TCR signaling R-HSA-202403 9.995398e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.995974e-01 0.000 0 0
Hedgehog 'on' state R-HSA-5632684 9.995974e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.996424e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.996748e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.996750e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.997129e-01 0.000 0 0
G alpha (z) signalling events R-HSA-418597 9.997145e-01 0.000 0 0
Integration of energy metabolism R-HSA-163685 9.997154e-01 0.000 0 0
Downstream TCR signaling R-HSA-202424 9.997432e-01 0.000 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.997857e-01 0.000 0 0
PCP/CE pathway R-HSA-4086400 9.998247e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.998247e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.998302e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.998508e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.998508e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.998665e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.998775e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.998800e-01 0.000 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.998850e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998952e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998952e-01 0.000 0 0
Developmental Cell Lineages R-HSA-9734767 9.999019e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.999164e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999164e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999197e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999253e-01 0.000 0 0
Hedgehog 'off' state R-HSA-5610787 9.999333e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.999333e-01 0.000 0 0
Transmission across Chemical Synapses R-HSA-112315 9.999339e-01 0.000 0 0
Signaling by Hedgehog R-HSA-5358351 9.999341e-01 0.000 0 0
Neuronal System R-HSA-112316 9.999363e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999370e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999404e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999471e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999643e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999686e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999709e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999758e-01 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.999773e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999787e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999810e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999826e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.999855e-01 0.000 0 0
Protein localization R-HSA-9609507 9.999870e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999874e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999903e-01 0.000 0 0
Neutrophil degranulation R-HSA-6798695 9.999911e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999915e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999922e-01 0.000 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.999922e-01 0.000 0 0
Interferon gamma signaling R-HSA-877300 9.999930e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999940e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999955e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999970e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999971e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999973e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999979e-01 0.000 0 0
Hemostasis R-HSA-109582 9.999979e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999980e-01 0.000 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.999982e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999982e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999984e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999985e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.999987e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999988e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.999988e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.999988e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999993e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999993e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999994e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999994e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999995e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999997e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999997e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999998e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999999e-01 0.000 0 0
Translation R-HSA-72766 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
G alpha (q) signalling events R-HSA-416476 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Immune System R-HSA-168256 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 -0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 2.220446e-16 15.654 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.109424e-15 14.676 0 0
HSF1-dependent transactivation R-HSA-3371571 5.124789e-13 12.290 0 0
Attenuation phase R-HSA-3371568 6.095124e-13 12.215 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.670764e-11 10.176 0 0
Cell Cycle R-HSA-1640170 1.332340e-10 9.875 0 0
Cell Cycle, Mitotic R-HSA-69278 1.880932e-10 9.726 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.026518e-08 7.989 0 0
HSF1 activation R-HSA-3371511 2.612559e-08 7.583 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.171318e-08 7.499 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.603970e-08 7.337 0 0
Cellular responses to stress R-HSA-2262752 4.541380e-08 7.343 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 7.332879e-08 7.135 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.015444e-07 6.993 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.031808e-07 6.986 0 0
Metabolism of RNA R-HSA-8953854 9.765190e-08 7.010 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.800790e-07 6.745 0 0
M Phase R-HSA-68886 2.322953e-07 6.634 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.666553e-07 6.574 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.602205e-07 6.065 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.507152e-06 5.822 0 0
Nuclear import of Rev protein R-HSA-180746 1.574203e-06 5.803 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.552888e-06 5.809 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.094339e-06 5.679 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.094339e-06 5.679 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.061150e-06 5.686 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.061150e-06 5.686 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.878665e-06 5.541 0 0
Cellular responses to stimuli R-HSA-8953897 2.898512e-06 5.538 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.060484e-06 5.514 0 0
Apoptotic execution phase R-HSA-75153 3.205206e-06 5.494 0 0
Mitotic Anaphase R-HSA-68882 3.364685e-06 5.473 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.915948e-06 5.407 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.739783e-06 5.427 0 0
Chromatin organization R-HSA-4839726 4.276136e-06 5.369 0 0
Nervous system development R-HSA-9675108 4.819524e-06 5.317 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.002675e-06 5.301 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.025247e-06 5.299 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.274886e-06 5.278 0 0
mRNA Splicing - Major Pathway R-HSA-72163 7.238469e-06 5.140 0 0
Axon guidance R-HSA-422475 7.296790e-06 5.137 0 0
Influenza Infection R-HSA-168255 7.190006e-06 5.143 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.614286e-06 5.118 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 9.310830e-06 5.031 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.027975e-05 4.988 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.103284e-05 4.957 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.166280e-05 4.933 0 0
Chromatin modifying enzymes R-HSA-3247509 2.007032e-05 4.697 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.130355e-05 4.672 0 0
mRNA Splicing R-HSA-72172 2.254595e-05 4.647 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.442738e-05 4.352 0 0
Mitotic Prophase R-HSA-68875 4.993064e-05 4.302 0 0
Gene expression (Transcription) R-HSA-74160 6.265976e-05 4.203 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.089003e-05 4.149 0 0
Separation of Sister Chromatids R-HSA-2467813 7.407670e-05 4.130 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.809176e-05 4.055 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.004408e-04 3.998 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.126138e-04 3.948 0 0
Signal Transduction R-HSA-162582 1.197727e-04 3.922 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.243553e-04 3.905 0 0
Death Receptor Signaling R-HSA-73887 1.275912e-04 3.894 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.357181e-04 3.867 0 0
Mitotic Prometaphase R-HSA-68877 1.403179e-04 3.853 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.472053e-04 3.832 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.472053e-04 3.832 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.524434e-04 3.817 0 0
HIV Life Cycle R-HSA-162587 1.725987e-04 3.763 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.830878e-04 3.737 0 0
Signaling by Hippo R-HSA-2028269 2.075286e-04 3.683 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.170421e-04 3.663 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.313651e-04 3.636 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.676402e-04 3.572 0 0
tRNA processing in the nucleus R-HSA-6784531 2.722882e-04 3.565 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.620007e-04 3.441 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.515725e-04 3.454 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.717044e-04 3.430 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.137632e-04 3.383 0 0
Cap-dependent Translation Initiation R-HSA-72737 4.142345e-04 3.383 0 0
Eukaryotic Translation Initiation R-HSA-72613 4.142345e-04 3.383 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.248199e-04 3.372 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.872326e-04 3.312 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.872326e-04 3.312 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.872326e-04 3.312 0 0
snRNP Assembly R-HSA-191859 4.851886e-04 3.314 0 0
Metabolism of non-coding RNA R-HSA-194441 4.851886e-04 3.314 0 0
Signaling by RAS mutants R-HSA-6802949 4.872326e-04 3.312 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.144586e-04 3.289 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.184265e-04 3.285 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.325266e-04 3.274 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.417972e-04 3.266 0 0
Recycling pathway of L1 R-HSA-437239 5.810931e-04 3.236 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.058190e-04 3.218 0 0
Glycolysis R-HSA-70171 6.058190e-04 3.218 0 0
Signaling by RAF1 mutants R-HSA-9656223 6.187420e-04 3.208 0 0
Translation initiation complex formation R-HSA-72649 6.296271e-04 3.201 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.824073e-04 3.166 0 0
S Phase R-HSA-69242 6.868299e-04 3.163 0 0
Signaling by ROBO receptors R-HSA-376176 6.456172e-04 3.190 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.993777e-04 3.155 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.196295e-04 3.143 0 0
Cellular Senescence R-HSA-2559583 7.362346e-04 3.133 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.800322e-04 3.108 0 0
G0 and Early G1 R-HSA-1538133 7.919581e-04 3.101 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.621793e-04 3.064 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.195662e-04 3.086 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.019468e-04 3.096 0 0
NRAGE signals death through JNK R-HSA-193648 8.621793e-04 3.064 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 8.864424e-04 3.052 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.614052e-04 3.017 0 0
Oncogenic MAPK signaling R-HSA-6802957 9.767001e-04 3.010 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.906961e-04 3.004 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.004637e-03 2.998 0 0
mTORC1-mediated signalling R-HSA-166208 1.137442e-03 2.944 0 0
HIV Infection R-HSA-162906 1.188609e-03 2.925 0 0
G2/M Transition R-HSA-69275 1.188922e-03 2.925 0 0
mRNA 3'-end processing R-HSA-72187 1.313180e-03 2.882 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.386190e-03 2.858 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.604470e-03 2.795 0 0
Developmental Biology R-HSA-1266738 1.623509e-03 2.790 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.755961e-03 2.755 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.813067e-03 2.742 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.813067e-03 2.742 0 0
MAP2K and MAPK activation R-HSA-5674135 1.905566e-03 2.720 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.853868e-03 2.732 0 0
L1CAM interactions R-HSA-373760 1.988684e-03 2.701 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.992964e-03 2.701 0 0
Host Interactions of HIV factors R-HSA-162909 2.003991e-03 2.698 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.114473e-03 2.675 0 0
MTOR signalling R-HSA-165159 2.242798e-03 2.649 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.250036e-03 2.648 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.250036e-03 2.648 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.376177e-03 2.624 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.376177e-03 2.624 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.436774e-03 2.613 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.460903e-03 2.609 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.460903e-03 2.609 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.708303e-03 2.567 0 0
Cell Cycle Checkpoints R-HSA-69620 2.891416e-03 2.539 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.886950e-03 2.540 0 0
Membrane Trafficking R-HSA-199991 3.097909e-03 2.509 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.124103e-03 2.505 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.124103e-03 2.505 0 0
Signaling by ALK in cancer R-HSA-9700206 3.124103e-03 2.505 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.191272e-03 2.496 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.427069e-03 2.465 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.533963e-03 2.452 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.557444e-03 2.449 0 0
Peptide chain elongation R-HSA-156902 3.581717e-03 2.446 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.801582e-03 2.420 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.060757e-03 2.391 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 3.886984e-03 2.410 0 0
RNA Polymerase II Transcription R-HSA-73857 3.696777e-03 2.432 0 0
Deubiquitination R-HSA-5688426 4.087507e-03 2.389 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.112187e-03 2.386 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.122542e-03 2.385 0 0
Glucose metabolism R-HSA-70326 4.480016e-03 2.349 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.514141e-03 2.345 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.649761e-03 2.333 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.695736e-03 2.328 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.858203e-03 2.314 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.887433e-03 2.311 0 0
Transport of connexons to the plasma membrane R-HSA-190872 5.218474e-03 2.282 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.297354e-03 2.276 0 0
Signaling by NOTCH3 R-HSA-9012852 5.302171e-03 2.276 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.318662e-03 2.274 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.445989e-03 2.264 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 6.177981e-03 2.209 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.814389e-03 2.235 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.814389e-03 2.235 0 0
HATs acetylate histones R-HSA-3214847 5.929595e-03 2.227 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.184686e-03 2.209 0 0
G alpha (12/13) signalling events R-HSA-416482 5.660185e-03 2.247 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.040841e-03 2.219 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.911631e-03 2.228 0 0
Gap junction trafficking and regulation R-HSA-157858 6.205818e-03 2.207 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.785144e-03 2.168 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 6.954352e-03 2.158 0 0
PKR-mediated signaling R-HSA-9833482 6.961426e-03 2.157 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.514053e-03 2.124 0 0
HCMV Early Events R-HSA-9609690 7.763094e-03 2.110 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.786073e-03 2.109 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.799058e-03 2.108 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.873472e-03 2.104 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 7.909482e-03 2.102 0 0
DCC mediated attractive signaling R-HSA-418885 7.937192e-03 2.100 0 0
Integrin signaling R-HSA-354192 9.574767e-03 2.019 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.537184e-03 2.021 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 9.242026e-03 2.034 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 9.574767e-03 2.019 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.318356e-03 2.031 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.010097e-03 2.045 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 9.107172e-03 2.041 0 0
Eukaryotic Translation Termination R-HSA-72764 8.531569e-03 2.069 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.574767e-03 2.019 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 9.638153e-03 2.016 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 1.003059e-02 1.999 0 0
Inhibition of nitric oxide production R-HSA-9636249 1.067901e-02 1.971 0 0
MET interacts with TNS proteins R-HSA-8875513 1.067901e-02 1.971 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.067901e-02 1.971 0 0
Aggrephagy R-HSA-9646399 1.105865e-02 1.956 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.147799e-02 1.940 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.187205e-02 1.925 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.197501e-02 1.922 0 0
EPH-Ephrin signaling R-HSA-2682334 1.223479e-02 1.912 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.237500e-02 1.907 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.263233e-02 1.899 0 0
RAF activation R-HSA-5673000 1.287898e-02 1.890 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.314439e-02 1.881 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.314439e-02 1.881 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.314439e-02 1.881 0 0
Selenocysteine synthesis R-HSA-2408557 1.416426e-02 1.849 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.420087e-02 1.848 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.420087e-02 1.848 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.420087e-02 1.848 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.420087e-02 1.848 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.420087e-02 1.848 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.420087e-02 1.848 0 0
Regulation of gap junction activity R-HSA-191650 1.728794e-02 1.762 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.728794e-02 1.762 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.728794e-02 1.762 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.534230e-02 1.814 0 0
Viral mRNA Translation R-HSA-192823 1.658194e-02 1.780 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.493761e-02 1.826 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.592880e-02 1.798 0 0
Signaling by VEGF R-HSA-194138 1.713146e-02 1.766 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.741054e-02 1.759 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.775662e-02 1.751 0 0
Formation of annular gap junctions R-HSA-196025 1.796222e-02 1.746 0 0
MET receptor recycling R-HSA-8875656 1.796222e-02 1.746 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.796222e-02 1.746 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.797952e-02 1.745 0 0
Inositol phosphate metabolism R-HSA-1483249 1.860113e-02 1.730 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.895515e-02 1.722 0 0
Formation of axial mesoderm R-HSA-9796292 1.947971e-02 1.710 0 0
Regulation of beta-cell development R-HSA-186712 1.966668e-02 1.706 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.997787e-02 1.699 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.024003e-02 1.694 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.064889e-02 1.685 0 0
Gap junction trafficking R-HSA-190828 2.064889e-02 1.685 0 0
UCH proteinases R-HSA-5689603 2.150698e-02 1.667 0 0
Interferon Signaling R-HSA-913531 2.231024e-02 1.651 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.317280e-02 1.635 0 0
FOXO-mediated transcription R-HSA-9614085 2.325525e-02 1.633 0 0
Gap junction degradation R-HSA-190873 2.375035e-02 1.624 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.572718e-02 1.590 0 0
Nuclear RNA decay R-HSA-9930044 2.609998e-02 1.583 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.653603e-02 1.576 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.653603e-02 1.576 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.686988e-02 1.571 0 0
p75NTR signals via NF-kB R-HSA-193639 2.946901e-02 1.531 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.054800e-02 1.515 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.054800e-02 1.515 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.094891e-02 1.509 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.093034e-02 1.510 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.192690e-02 1.496 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.093034e-02 1.510 0 0
Generic Transcription Pathway R-HSA-212436 3.417663e-02 1.466 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.013893e-02 1.521 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.542384e-02 1.451 0 0
Regulation of CDH1 Function R-HSA-9764561 3.504898e-02 1.455 0 0
Signaling by EGFR R-HSA-177929 3.192690e-02 1.496 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.361379e-02 1.473 0 0
Selective autophagy R-HSA-9663891 3.141330e-02 1.503 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.535092e-02 1.452 0 0
Phosphorylation of the APC/C R-HSA-176412 3.548213e-02 1.450 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.600133e-02 1.444 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.600133e-02 1.444 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.600133e-02 1.444 0 0
Signaling by NOTCH4 R-HSA-9013694 3.646054e-02 1.438 0 0
Oncogene Induced Senescence R-HSA-2559585 3.769833e-02 1.424 0 0
Apoptosis R-HSA-109581 3.793937e-02 1.421 0 0
Nucleotide Excision Repair R-HSA-5696398 3.797641e-02 1.420 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.869038e-02 1.412 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.040000e-02 1.394 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.092898e-02 1.388 0 0
Disorders of Developmental Biology R-HSA-9675151 4.219959e-02 1.375 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.219959e-02 1.375 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.219959e-02 1.375 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 4.219959e-02 1.375 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 4.219959e-02 1.375 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.219959e-02 1.375 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.222689e-02 1.374 0 0
RNA Polymerase III Transcription R-HSA-74158 4.222689e-02 1.374 0 0
FLT3 signaling in disease R-HSA-9682385 4.222689e-02 1.374 0 0
RET signaling R-HSA-8853659 4.222689e-02 1.374 0 0
Signaling by NOTCH1 R-HSA-1980143 4.266164e-02 1.370 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.272835e-02 1.369 0 0
Ribosome-associated quality control R-HSA-9948299 4.324837e-02 1.364 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.363090e-02 1.360 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.363090e-02 1.360 0 0
Regulation of TP53 Expression R-HSA-6804754 5.056307e-02 1.296 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.963276e-02 1.304 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.133709e-02 1.290 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.569031e-02 1.340 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.185131e-02 1.285 0 0
Signaling by ERBB2 R-HSA-1227986 4.569031e-02 1.340 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.210994e-02 1.283 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.710140e-02 1.327 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.569031e-02 1.340 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.569031e-02 1.340 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.569031e-02 1.340 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.569031e-02 1.340 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.179809e-02 1.286 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.601383e-02 1.337 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.389862e-02 1.268 0 0
HCMV Infection R-HSA-9609646 4.836165e-02 1.315 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.569031e-02 1.340 0 0
rRNA processing R-HSA-72312 5.072341e-02 1.295 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 5.056307e-02 1.296 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 4.806960e-02 1.318 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.179809e-02 1.286 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.389862e-02 1.268 0 0
Smooth Muscle Contraction R-HSA-445355 5.113231e-02 1.291 0 0
Macroautophagy R-HSA-1632852 5.082992e-02 1.294 0 0
Cell-Cell communication R-HSA-1500931 4.535935e-02 1.343 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.428980e-02 1.265 0 0
Interleukin-37 signaling R-HSA-9008059 4.560847e-02 1.341 0 0
Post NMDA receptor activation events R-HSA-438064 5.428980e-02 1.265 0 0
Viral Infection Pathways R-HSA-9824446 5.475647e-02 1.262 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.518298e-02 1.258 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 5.518298e-02 1.258 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.716748e-02 1.243 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.716748e-02 1.243 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.716748e-02 1.243 0 0
Disorders of Nervous System Development R-HSA-9697154 5.716748e-02 1.243 0 0
Pervasive developmental disorders R-HSA-9005895 5.716748e-02 1.243 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.716748e-02 1.243 0 0
Ephrin signaling R-HSA-3928664 5.778695e-02 1.238 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.778695e-02 1.238 0 0
Polo-like kinase mediated events R-HSA-156711 5.778695e-02 1.238 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.778695e-02 1.238 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.835010e-02 1.234 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.835010e-02 1.234 0 0
Semaphorin interactions R-HSA-373755 5.835010e-02 1.234 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.839795e-02 1.234 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.089804e-02 1.215 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.185621e-02 1.209 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.185621e-02 1.209 0 0
SOS-mediated signalling R-HSA-112412 6.185621e-02 1.209 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.185621e-02 1.209 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.226477e-02 1.206 0 0
Long-term potentiation R-HSA-9620244 6.252525e-02 1.204 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.256603e-02 1.204 0 0
SARS-CoV Infections R-HSA-9679506 6.278974e-02 1.202 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.409966e-02 1.193 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.462935e-02 1.190 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.462935e-02 1.190 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.666166e-02 1.176 0 0
Cell junction organization R-HSA-446728 6.691183e-02 1.174 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.749682e-02 1.171 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 6.810498e-02 1.167 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 6.810498e-02 1.167 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.810498e-02 1.167 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 8.554508e-02 1.068 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 8.554508e-02 1.068 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.554508e-02 1.068 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 8.554508e-02 1.068 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 8.554508e-02 1.068 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 7.459019e-02 1.127 0 0
MET activates PTPN11 R-HSA-8865999 7.459019e-02 1.127 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.725905e-02 1.112 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.725905e-02 1.112 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 9.293438e-02 1.032 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 9.293438e-02 1.032 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.654293e-02 1.063 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.885402e-02 1.103 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.862307e-02 1.104 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.313278e-02 1.136 0 0
Centrosome maturation R-HSA-380287 7.425084e-02 1.129 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.000883e-02 1.046 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.018023e-02 1.154 0 0
Formation of definitive endoderm R-HSA-9823730 7.625078e-02 1.118 0 0
G1/S Transition R-HSA-69206 8.415343e-02 1.075 0 0
Negative regulation of MAPK pathway R-HSA-5675221 7.686392e-02 1.114 0 0
Adipogenesis R-HSA-9843745 7.483453e-02 1.126 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 7.426754e-02 1.129 0 0
Regulation of TP53 Activity R-HSA-5633007 8.458684e-02 1.073 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.654293e-02 1.063 0 0
MAPK family signaling cascades R-HSA-5683057 9.072387e-02 1.042 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.313278e-02 1.136 0 0
Gap junction assembly R-HSA-190861 7.862307e-02 1.104 0 0
Cellular response to starvation R-HSA-9711097 7.741498e-02 1.111 0 0
Regulation of PTEN gene transcription R-HSA-8943724 8.915999e-02 1.050 0 0
Signaling by TGFB family members R-HSA-9006936 8.458684e-02 1.073 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 7.459019e-02 1.127 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.114073e-02 1.148 0 0
Autophagy R-HSA-9612973 7.066460e-02 1.151 0 0
Protein folding R-HSA-391251 7.947147e-02 1.100 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.960861e-02 1.099 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 9.293438e-02 1.032 0 0
Signaling by NTRKs R-HSA-166520 7.557703e-02 1.122 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 8.419997e-02 1.075 0 0
Programmed Cell Death R-HSA-5357801 8.062596e-02 1.094 0 0
Gene Silencing by RNA R-HSA-211000 7.396771e-02 1.131 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.389764e-02 1.131 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 9.415704e-02 1.026 0 0
Unwinding of DNA R-HSA-176974 9.415704e-02 1.026 0 0
GP1b-IX-V activation signalling R-HSA-430116 9.415704e-02 1.026 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 9.415704e-02 1.026 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.418394e-02 1.026 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.490394e-02 1.023 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.734873e-02 1.012 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.734873e-02 1.012 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.752183e-02 1.011 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.752183e-02 1.011 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 9.752183e-02 1.011 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.830698e-02 1.007 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.014520e-01 0.994 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.014520e-01 0.994 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.014553e-01 0.994 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.014553e-01 0.994 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.014553e-01 0.994 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.014553e-01 0.994 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.014553e-01 0.994 0 0
Heme signaling R-HSA-9707616 1.024959e-01 0.989 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.036939e-01 0.984 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.054143e-01 0.977 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.067456e-01 0.972 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.072666e-01 0.970 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.073874e-01 0.969 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.091667e-01 0.962 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.092715e-01 0.961 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.095747e-01 0.960 0 0
Signaling by PTK6 R-HSA-8848021 1.095747e-01 0.960 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.124161e-01 0.949 0 0
PI3K/AKT activation R-HSA-198203 1.124161e-01 0.949 0 0
Signal attenuation R-HSA-74749 1.124161e-01 0.949 0 0
MET promotes cell motility R-HSA-8875878 1.129080e-01 0.947 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.131226e-01 0.946 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.157695e-01 0.936 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.169187e-01 0.932 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.193980e-01 0.923 0 0
Synthesis of DNA R-HSA-69239 1.203532e-01 0.920 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.214216e-01 0.916 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.214527e-01 0.916 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.245421e-01 0.905 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.246231e-01 0.904 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.251096e-01 0.903 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.637768e-01 0.786 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.637768e-01 0.786 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.637768e-01 0.786 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 1.637768e-01 0.786 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 1.637768e-01 0.786 0 0
IRS activation R-HSA-74713 1.304977e-01 0.884 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.304977e-01 0.884 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.304977e-01 0.884 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.304977e-01 0.884 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.611488e-01 0.793 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.611488e-01 0.793 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.611488e-01 0.793 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.611488e-01 0.793 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.611488e-01 0.793 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 1.524448e-01 0.817 0 0
Signaling by AXIN mutants R-HSA-4839735 1.524448e-01 0.817 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.524448e-01 0.817 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.739218e-01 0.760 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.739218e-01 0.760 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.739218e-01 0.760 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.343515e-01 0.872 0 0
Deadenylation of mRNA R-HSA-429947 1.343515e-01 0.872 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.700485e-01 0.769 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.700485e-01 0.769 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.618576e-01 0.791 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.763941e-01 0.754 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.763941e-01 0.754 0 0
Striated Muscle Contraction R-HSA-390522 1.524838e-01 0.817 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 1.325719e-01 0.878 0 0
HIV elongation arrest and recovery R-HSA-167287 1.914021e-01 0.718 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.914021e-01 0.718 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 1.538061e-01 0.813 0 0
HIV Transcription Initiation R-HSA-167161 1.538061e-01 0.813 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 1.538061e-01 0.813 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 1.764978e-01 0.753 0 0
Transcription of the HIV genome R-HSA-167172 1.489609e-01 0.827 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.875758e-01 0.727 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.458969e-01 0.836 0 0
DNA strand elongation R-HSA-69190 1.289817e-01 0.889 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.524448e-01 0.817 0 0
Myogenesis R-HSA-525793 1.618576e-01 0.791 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.756147e-01 0.755 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.393954e-01 0.856 0 0
G1 Phase R-HSA-69236 1.883496e-01 0.725 0 0
Cyclin D associated events in G1 R-HSA-69231 1.883496e-01 0.725 0 0
NF-kB is activated and signals survival R-HSA-209560 1.524448e-01 0.817 0 0
Activation of RAC1 R-HSA-428540 1.524448e-01 0.817 0 0
Signaling by NOTCH2 R-HSA-1980145 1.648994e-01 0.783 0 0
Repression of WNT target genes R-HSA-4641265 1.739218e-01 0.760 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.304977e-01 0.884 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.304977e-01 0.884 0 0
G-protein beta:gamma signalling R-HSA-397795 1.405040e-01 0.852 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.405040e-01 0.852 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.404732e-01 0.852 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.883760e-01 0.725 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.904040e-01 0.720 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.808683e-01 0.743 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.318940e-01 0.880 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.875758e-01 0.727 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.538061e-01 0.813 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.429992e-01 0.845 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.325719e-01 0.878 0 0
Vesicle-mediated transport R-HSA-5653656 1.590509e-01 0.798 0 0
Inhibition of PKR R-HSA-169131 1.637768e-01 0.786 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.524448e-01 0.817 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.343515e-01 0.872 0 0
TBC/RABGAPs R-HSA-8854214 1.764978e-01 0.753 0 0
DNA Repair R-HSA-73894 1.301358e-01 0.886 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.914021e-01 0.718 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.338199e-01 0.873 0 0
RUNX2 regulates bone development R-HSA-8941326 1.909429e-01 0.719 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.763941e-01 0.754 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.283843e-01 0.891 0 0
Adherens junctions interactions R-HSA-418990 1.288755e-01 0.890 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.756147e-01 0.755 0 0
TGFBR3 expression R-HSA-9839394 1.478312e-01 0.830 0 0
FLT3 Signaling R-HSA-9607240 1.429992e-01 0.845 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.425399e-01 0.846 0 0
NGF-stimulated transcription R-HSA-9031628 1.338199e-01 0.873 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.764978e-01 0.753 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.574849e-01 0.803 0 0
Kinesins R-HSA-983189 1.607920e-01 0.794 0 0
NrCAM interactions R-HSA-447038 1.304977e-01 0.884 0 0
Sensory processing of sound R-HSA-9659379 1.623219e-01 0.790 0 0
MHC class II antigen presentation R-HSA-2132295 1.734226e-01 0.761 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.405040e-01 0.852 0 0
Specification of primordial germ cells R-HSA-9827857 1.369056e-01 0.864 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.304977e-01 0.884 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.304977e-01 0.884 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.611488e-01 0.793 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.531361e-01 0.815 0 0
RMTs methylate histone arginines R-HSA-3214858 1.883496e-01 0.725 0 0
Signaling by Interleukins R-HSA-449147 1.818886e-01 0.740 0 0
Selenoamino acid metabolism R-HSA-2408522 1.464826e-01 0.834 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.929215e-01 0.715 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.929215e-01 0.715 0 0
Nef and signal transduction R-HSA-164944 1.929215e-01 0.715 0 0
Interleukin-1 family signaling R-HSA-446652 1.939939e-01 0.712 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.954836e-01 0.709 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.956662e-01 0.708 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.961800e-01 0.707 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.961800e-01 0.707 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.961800e-01 0.707 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 2.005149e-01 0.698 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.016151e-01 0.695 0 0
Rab regulation of trafficking R-HSA-9007101 2.019829e-01 0.695 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.045200e-01 0.689 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.056496e-01 0.687 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.056496e-01 0.687 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.068418e-01 0.684 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.353201e-01 0.628 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.353201e-01 0.628 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.353201e-01 0.628 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.353201e-01 0.628 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.007464e-01 0.522 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.007464e-01 0.522 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.007464e-01 0.522 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.007464e-01 0.522 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.007464e-01 0.522 0 0
Defective AHCY causes HMAHCHD R-HSA-5578997 3.007464e-01 0.522 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.007464e-01 0.522 0 0
Defective ABCD1 causes ALD R-HSA-5684045 3.007464e-01 0.522 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.007464e-01 0.522 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.007464e-01 0.522 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.007464e-01 0.522 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.007464e-01 0.522 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.007464e-01 0.522 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.007464e-01 0.522 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.007464e-01 0.522 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.007464e-01 0.522 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.007464e-01 0.522 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.007464e-01 0.522 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.253999e-01 0.647 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.253999e-01 0.647 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.253999e-01 0.647 0 0
Axonal growth stimulation R-HSA-209563 3.605783e-01 0.443 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.605783e-01 0.443 0 0
Invadopodia formation R-HSA-8941237 3.605783e-01 0.443 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.605783e-01 0.443 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.605783e-01 0.443 0 0
Type I hemidesmosome assembly R-HSA-446107 2.582310e-01 0.588 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.911170e-01 0.536 0 0
ARMS-mediated activation R-HSA-170984 2.911170e-01 0.536 0 0
WNT mediated activation of DVL R-HSA-201688 2.911170e-01 0.536 0 0
ALK mutants bind TKIs R-HSA-9700645 2.911170e-01 0.536 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.152939e-01 0.382 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.152939e-01 0.382 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.152939e-01 0.382 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.152939e-01 0.382 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.152939e-01 0.382 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.424823e-01 0.615 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.424823e-01 0.615 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.238086e-01 0.490 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.242010e-01 0.649 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.242010e-01 0.649 0 0
FGFR2 alternative splicing R-HSA-6803529 2.431614e-01 0.614 0 0
Notch-HLH transcription pathway R-HSA-350054 2.431614e-01 0.614 0 0
Signaling by APC mutants R-HSA-4839744 3.560983e-01 0.448 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.560983e-01 0.448 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.560983e-01 0.448 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.560983e-01 0.448 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.878158e-01 0.411 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.878158e-01 0.411 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.878158e-01 0.411 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.878158e-01 0.411 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.553377e-01 0.593 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.386936e-01 0.470 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.386936e-01 0.470 0 0
GAB1 signalosome R-HSA-180292 3.386936e-01 0.470 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.386936e-01 0.470 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.129747e-01 0.672 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.257095e-01 0.646 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.185326e-01 0.660 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.217589e-01 0.492 0 0
MET activates RAS signaling R-HSA-8851805 4.188226e-01 0.378 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.188226e-01 0.378 0 0
Leading Strand Synthesis R-HSA-69109 4.188226e-01 0.378 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.188226e-01 0.378 0 0
Polymerase switching R-HSA-69091 4.188226e-01 0.378 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.188226e-01 0.378 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.188226e-01 0.378 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.188226e-01 0.378 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.188226e-01 0.378 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.618342e-01 0.441 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.618342e-01 0.441 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.557867e-01 0.592 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.927830e-01 0.533 0 0
G1/S-Specific Transcription R-HSA-69205 3.409196e-01 0.467 0 0
Lagging Strand Synthesis R-HSA-69186 4.106577e-01 0.387 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.067284e-01 0.513 0 0
Nucleosome assembly R-HSA-774815 3.383592e-01 0.471 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.383592e-01 0.471 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.349773e-01 0.475 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.539986e-01 0.451 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.018232e-01 0.396 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.018232e-01 0.396 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.018232e-01 0.396 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.492383e-01 0.457 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 3.696889e-01 0.432 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.854036e-01 0.414 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.108028e-01 0.386 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.108028e-01 0.386 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 3.990919e-01 0.399 0 0
HIV Transcription Elongation R-HSA-167169 4.108028e-01 0.386 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.790557e-01 0.554 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.790557e-01 0.554 0 0
Signaling by MET R-HSA-6806834 2.669236e-01 0.574 0 0
Chromosome Maintenance R-HSA-73886 2.338106e-01 0.631 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.144769e-01 0.502 0 0
Circadian clock R-HSA-9909396 2.567819e-01 0.590 0 0
Activation of the pre-replicative complex R-HSA-68962 2.226721e-01 0.652 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.462230e-01 0.461 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.326504e-01 0.633 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.989618e-01 0.524 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.108028e-01 0.386 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.975664e-01 0.401 0 0
Developmental Cell Lineages R-HSA-9734767 2.547901e-01 0.594 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.417809e-01 0.466 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.868670e-01 0.412 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.067284e-01 0.513 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.417809e-01 0.466 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.253999e-01 0.647 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.253999e-01 0.647 0 0
Regulation of CDH11 function R-HSA-9762292 3.238086e-01 0.490 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.662626e-01 0.575 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.431614e-01 0.614 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.560983e-01 0.448 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 3.878158e-01 0.411 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.933608e-01 0.405 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 4.108028e-01 0.386 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.386936e-01 0.470 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.062203e-01 0.514 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.922508e-01 0.534 0 0
Generation of second messenger molecules R-HSA-202433 4.108028e-01 0.386 0 0
p75NTR regulates axonogenesis R-HSA-193697 2.911170e-01 0.536 0 0
Trafficking of AMPA receptors R-HSA-399719 2.388514e-01 0.622 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.188226e-01 0.378 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.188226e-01 0.378 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.161970e-01 0.665 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.927830e-01 0.533 0 0
Signal transduction by L1 R-HSA-445144 3.868670e-01 0.412 0 0
Integration of provirus R-HSA-162592 3.878158e-01 0.411 0 0
Degradation of DVL R-HSA-4641258 3.583846e-01 0.446 0 0
Interleukin-1 signaling R-HSA-9020702 3.045985e-01 0.516 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 2.582310e-01 0.588 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.902984e-01 0.537 0 0
Formation of the posterior neural plate R-HSA-9832991 3.560983e-01 0.448 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.920203e-01 0.535 0 0
G2/M Checkpoints R-HSA-69481 3.936733e-01 0.405 0 0
DNA Replication R-HSA-69306 3.637509e-01 0.439 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.226721e-01 0.652 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.519223e-01 0.599 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.519223e-01 0.599 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.443969e-01 0.612 0 0
Prolonged ERK activation events R-HSA-169893 2.662626e-01 0.575 0 0
Neurexins and neuroligins R-HSA-6794361 2.927830e-01 0.533 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.733965e-01 0.563 0 0
Homology Directed Repair R-HSA-5693538 4.015391e-01 0.396 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.417809e-01 0.466 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.545517e-01 0.594 0 0
Signaling by SCF-KIT R-HSA-1433557 3.073420e-01 0.512 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 2.768614e-01 0.558 0 0
Signaling by NODAL R-HSA-1181150 3.868670e-01 0.412 0 0
Activation of BH3-only proteins R-HSA-114452 4.018232e-01 0.396 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.244956e-01 0.649 0 0
Signaling by WNT R-HSA-195721 4.088955e-01 0.388 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.933608e-01 0.405 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.627566e-01 0.580 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.911170e-01 0.536 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.051130e-01 0.516 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.820389e-01 0.550 0 0
Signalling to ERKs R-HSA-187687 3.235188e-01 0.490 0 0
Mismatch Repair R-HSA-5358508 3.386936e-01 0.470 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.720890e-01 0.565 0 0
Signaling by NOTCH R-HSA-157118 3.097595e-01 0.509 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.353201e-01 0.628 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.353201e-01 0.628 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.353201e-01 0.628 0 0
Signalling to ERK5 R-HSA-198765 3.007464e-01 0.522 0 0
MET activates STAT3 R-HSA-8875791 3.605783e-01 0.443 0 0
Adrenoceptors R-HSA-390696 2.582310e-01 0.588 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.582310e-01 0.588 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.911170e-01 0.536 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.152939e-01 0.382 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.238086e-01 0.490 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.560983e-01 0.448 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.878158e-01 0.411 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.878158e-01 0.411 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.326278e-01 0.633 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.298574e-01 0.482 0 0
Cilium Assembly R-HSA-5617833 2.494687e-01 0.603 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.852653e-01 0.414 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.852653e-01 0.414 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.852653e-01 0.414 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.217589e-01 0.492 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.346148e-01 0.475 0 0
Pexophagy R-HSA-9664873 3.238086e-01 0.490 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.468744e-01 0.608 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.720890e-01 0.565 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.230810e-01 0.491 0 0
Ub-specific processing proteases R-HSA-5689880 2.766873e-01 0.558 0 0
MAP kinase activation R-HSA-450294 2.795252e-01 0.554 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.238086e-01 0.490 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.902984e-01 0.537 0 0
Rap1 signalling R-HSA-392517 3.628527e-01 0.440 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.448854e-01 0.462 0 0
HCMV Late Events R-HSA-9610379 3.076303e-01 0.512 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.238086e-01 0.490 0 0
Neurodegenerative Diseases R-HSA-8863678 2.820389e-01 0.550 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.820389e-01 0.550 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.890636e-01 0.539 0 0
Cell-cell junction organization R-HSA-421270 2.458805e-01 0.609 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.911170e-01 0.536 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.911170e-01 0.536 0 0
Signaling by LTK R-HSA-9842663 4.188226e-01 0.378 0 0
Interleukin-17 signaling R-HSA-448424 3.975664e-01 0.401 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.431614e-01 0.614 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.669533e-01 0.574 0 0
Regulation of KIT signaling R-HSA-1433559 2.190786e-01 0.659 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.188226e-01 0.378 0 0
Signaling by FGFR in disease R-HSA-1226099 3.149822e-01 0.502 0 0
Co-stimulation by CD28 R-HSA-389356 2.386990e-01 0.622 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.217589e-01 0.492 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.109226e-01 0.386 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.353201e-01 0.628 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.605783e-01 0.443 0 0
NADE modulates death signalling R-HSA-205025 4.152939e-01 0.382 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.238086e-01 0.490 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.720890e-01 0.565 0 0
Nephrin family interactions R-HSA-373753 3.868670e-01 0.412 0 0
Gastrulation R-HSA-9758941 3.290063e-01 0.483 0 0
Protein hydroxylation R-HSA-9629569 3.868670e-01 0.412 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.117979e-01 0.385 0 0
HDMs demethylate histones R-HSA-3214842 3.018250e-01 0.520 0 0
DNA Damage Bypass R-HSA-73893 4.011172e-01 0.397 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.909083e-01 0.536 0 0
Suppression of apoptosis R-HSA-9635465 3.560983e-01 0.448 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.720890e-01 0.565 0 0
The NLRP3 inflammasome R-HSA-844456 3.628527e-01 0.440 0 0
Netrin-1 signaling R-HSA-373752 3.227977e-01 0.491 0 0
Signaling by ALK R-HSA-201556 3.933608e-01 0.405 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.253999e-01 0.647 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.911170e-01 0.536 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.242010e-01 0.649 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.386936e-01 0.470 0 0
TNF signaling R-HSA-75893 2.185326e-01 0.660 0 0
Interleukin-1 processing R-HSA-448706 2.911170e-01 0.536 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.242010e-01 0.649 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 3.560983e-01 0.448 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.144769e-01 0.502 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.539986e-01 0.451 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.143016e-01 0.669 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.975664e-01 0.401 0 0
Interleukin-15 signaling R-HSA-8983432 4.188226e-01 0.378 0 0
Signaling by TGFBR3 R-HSA-9839373 3.539986e-01 0.451 0 0
Josephin domain DUBs R-HSA-5689877 3.238086e-01 0.490 0 0
tRNA processing R-HSA-72306 2.546874e-01 0.594 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.238086e-01 0.490 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.560983e-01 0.448 0 0
PECAM1 interactions R-HSA-210990 3.560983e-01 0.448 0 0
OAS antiviral response R-HSA-8983711 4.188226e-01 0.378 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.462230e-01 0.461 0 0
Signaling by Leptin R-HSA-2586552 3.238086e-01 0.490 0 0
IRE1alpha activates chaperones R-HSA-381070 4.168019e-01 0.380 0 0
Interleukin-12 signaling R-HSA-9020591 2.244792e-01 0.649 0 0
Interleukin-12 family signaling R-HSA-447115 3.578941e-01 0.446 0 0
Muscle contraction R-HSA-397014 4.201777e-01 0.377 0 0
Downstream signal transduction R-HSA-186763 4.216613e-01 0.375 0 0
EGFR downregulation R-HSA-182971 4.216613e-01 0.375 0 0
PTEN Regulation R-HSA-6807070 4.242581e-01 0.372 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.242686e-01 0.372 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 4.242686e-01 0.372 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.281707e-01 0.368 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.341544e-01 0.362 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.341544e-01 0.362 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.413357e-01 0.355 0 0
Orc1 removal from chromatin R-HSA-68949 4.480093e-01 0.349 0 0
Frs2-mediated activation R-HSA-170968 4.490084e-01 0.348 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.490084e-01 0.348 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.490084e-01 0.348 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.508716e-01 0.346 0 0
Signaling by ERBB4 R-HSA-1236394 4.508716e-01 0.346 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 4.572945e-01 0.340 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.572945e-01 0.340 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.572945e-01 0.340 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 4.572945e-01 0.340 0 0
Signaling by KIT in disease R-HSA-9669938 4.572945e-01 0.340 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.608059e-01 0.336 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.625640e-01 0.335 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.634815e-01 0.334 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.639327e-01 0.334 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.641002e-01 0.333 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 4.653305e-01 0.332 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.653305e-01 0.332 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 4.653305e-01 0.332 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.653305e-01 0.332 0 0
Suppression of autophagy R-HSA-9636569 4.653305e-01 0.332 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.653305e-01 0.332 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 4.653305e-01 0.332 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.653305e-01 0.332 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.740667e-01 0.324 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.748495e-01 0.323 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.756454e-01 0.323 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.782865e-01 0.320 0 0
Removal of the Flap Intermediate R-HSA-69166 4.782865e-01 0.320 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.782865e-01 0.320 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.782865e-01 0.320 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.782865e-01 0.320 0 0
Signal regulatory protein family interactions R-HSA-391160 4.782865e-01 0.320 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.795340e-01 0.319 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.800230e-01 0.319 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.800230e-01 0.319 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.800230e-01 0.319 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 4.800230e-01 0.319 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.800230e-01 0.319 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.800230e-01 0.319 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 4.800351e-01 0.319 0 0
Miscellaneous transport and binding events R-HSA-5223345 4.800351e-01 0.319 0 0
PPARA activates gene expression R-HSA-1989781 4.802389e-01 0.319 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.834774e-01 0.316 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.834774e-01 0.316 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.834774e-01 0.316 0 0
SLC transporter disorders R-HSA-5619102 4.881083e-01 0.311 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.989896e-01 0.302 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.989896e-01 0.302 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.018443e-01 0.299 0 0
PCP/CE pathway R-HSA-4086400 5.033354e-01 0.298 0 0
Erythropoietin activates RAS R-HSA-9027284 5.065914e-01 0.295 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.065914e-01 0.295 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.065914e-01 0.295 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.065914e-01 0.295 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.065914e-01 0.295 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.065914e-01 0.295 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.065914e-01 0.295 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.065914e-01 0.295 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.065914e-01 0.295 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.065914e-01 0.295 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.065914e-01 0.295 0 0
Protein methylation R-HSA-8876725 5.065914e-01 0.295 0 0
Formation of the anterior neural plate R-HSA-9823739 5.065914e-01 0.295 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.065914e-01 0.295 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.079594e-01 0.294 0 0
Ion homeostasis R-HSA-5578775 5.091355e-01 0.293 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.110878e-01 0.292 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.110878e-01 0.292 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.110878e-01 0.292 0 0
Phosphorylation of Emi1 R-HSA-176417 5.110878e-01 0.292 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.110878e-01 0.292 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.110878e-01 0.292 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.110878e-01 0.292 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.110878e-01 0.292 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.110878e-01 0.292 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.110878e-01 0.292 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.110878e-01 0.292 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.110878e-01 0.292 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.115317e-01 0.291 0 0
DAG and IP3 signaling R-HSA-1489509 5.128961e-01 0.290 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.176391e-01 0.286 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.188730e-01 0.285 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 5.240611e-01 0.281 0 0
Interleukin-7 signaling R-HSA-1266695 5.240611e-01 0.281 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.265902e-01 0.279 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.265902e-01 0.279 0 0
ESR-mediated signaling R-HSA-8939211 5.269024e-01 0.278 0 0
Signaling by FGFR2 R-HSA-5654738 5.289947e-01 0.277 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.297130e-01 0.276 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.297130e-01 0.276 0 0
Killing mechanisms R-HSA-9664420 5.338752e-01 0.273 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.338752e-01 0.273 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.338752e-01 0.273 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.338752e-01 0.273 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.338752e-01 0.273 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.359564e-01 0.271 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.452951e-01 0.263 0 0
TRP channels R-HSA-3295583 5.452951e-01 0.263 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.464443e-01 0.262 0 0
Signaling by LTK in cancer R-HSA-9842640 5.529317e-01 0.257 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.529317e-01 0.257 0 0
STAT5 Activation R-HSA-9645135 5.529317e-01 0.257 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.529317e-01 0.257 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.529317e-01 0.257 0 0
MET Receptor Activation R-HSA-6806942 5.529317e-01 0.257 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.529317e-01 0.257 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.529317e-01 0.257 0 0
Extension of Telomeres R-HSA-180786 5.532754e-01 0.257 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.573226e-01 0.254 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.573226e-01 0.254 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.577047e-01 0.254 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.601054e-01 0.252 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.601054e-01 0.252 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.601054e-01 0.252 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.601054e-01 0.252 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.601054e-01 0.252 0 0
Intraflagellar transport R-HSA-5620924 5.611753e-01 0.251 0 0
Gluconeogenesis R-HSA-70263 5.611753e-01 0.251 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.617242e-01 0.250 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.659655e-01 0.247 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.659655e-01 0.247 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.659655e-01 0.247 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.659655e-01 0.247 0 0
Insulin processing R-HSA-264876 5.659655e-01 0.247 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.715013e-01 0.243 0 0
Degradation of CDH1 R-HSA-9766229 5.767256e-01 0.239 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.816605e-01 0.235 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.816605e-01 0.235 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.852625e-01 0.233 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.852625e-01 0.233 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.852625e-01 0.233 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.852625e-01 0.233 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.852625e-01 0.233 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.852625e-01 0.233 0 0
Telomere Extension By Telomerase R-HSA-171319 5.860490e-01 0.232 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.860490e-01 0.232 0 0
Inflammasomes R-HSA-622312 5.860490e-01 0.232 0 0
RSV-host interactions R-HSA-9833110 5.884056e-01 0.230 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.886895e-01 0.230 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 5.911967e-01 0.228 0 0
IFNG signaling activates MAPKs R-HSA-9732724 5.911967e-01 0.228 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 5.911967e-01 0.228 0 0
Recycling of eIF2:GDP R-HSA-72731 5.911967e-01 0.228 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 5.911967e-01 0.228 0 0
Disinhibition of SNARE formation R-HSA-114516 5.911967e-01 0.228 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.911967e-01 0.228 0 0
VLDL clearance R-HSA-8964046 5.911967e-01 0.228 0 0
Netrin mediated repulsion signals R-HSA-418886 5.911967e-01 0.228 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 5.911967e-01 0.228 0 0
Regulation of PTEN localization R-HSA-8948747 5.911967e-01 0.228 0 0
CHL1 interactions R-HSA-447041 5.911967e-01 0.228 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.911967e-01 0.228 0 0
Signaling by PDGF R-HSA-186797 5.955034e-01 0.225 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.054667e-01 0.218 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.054667e-01 0.218 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.054667e-01 0.218 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.054667e-01 0.218 0 0
Signaling by Erythropoietin R-HSA-9006335 6.055275e-01 0.218 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.055275e-01 0.218 0 0
Late endosomal microautophagy R-HSA-9615710 6.055275e-01 0.218 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.055275e-01 0.218 0 0
mRNA Capping R-HSA-72086 6.055275e-01 0.218 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.093380e-01 0.215 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.093380e-01 0.215 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.093380e-01 0.215 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.093380e-01 0.215 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.093380e-01 0.215 0 0
Nephron development R-HSA-9831926 6.093380e-01 0.215 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.093380e-01 0.215 0 0
Protein ubiquitination R-HSA-8852135 6.116396e-01 0.214 0 0
IGF1R signaling cascade R-HSA-2428924 6.224390e-01 0.206 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.239748e-01 0.205 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.243873e-01 0.205 0 0
Activation of RAS in B cells R-HSA-1169092 6.261886e-01 0.203 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.261886e-01 0.203 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.261886e-01 0.203 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.261886e-01 0.203 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.261886e-01 0.203 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.261886e-01 0.203 0 0
Sodium/Proton exchangers R-HSA-425986 6.261886e-01 0.203 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 6.261886e-01 0.203 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.261886e-01 0.203 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.271730e-01 0.203 0 0
Telomere Maintenance R-HSA-157579 6.280372e-01 0.202 0 0
Regulation of signaling by CBL R-HSA-912631 6.323327e-01 0.199 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.323327e-01 0.199 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.323327e-01 0.199 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.323327e-01 0.199 0 0
Cellular response to hypoxia R-HSA-1234174 6.355145e-01 0.197 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.355145e-01 0.197 0 0
Meiotic synapsis R-HSA-1221632 6.358445e-01 0.197 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.377385e-01 0.195 0 0
Signaling by FGFR R-HSA-190236 6.387164e-01 0.195 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 6.426191e-01 0.192 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.426191e-01 0.192 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.479779e-01 0.188 0 0
RNA Polymerase I Transcription R-HSA-73864 6.479779e-01 0.188 0 0
TCR signaling R-HSA-202403 6.504185e-01 0.187 0 0
Negative regulation of MET activity R-HSA-6807004 6.542553e-01 0.184 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.551380e-01 0.184 0 0
Lipophagy R-HSA-9613354 6.581872e-01 0.182 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.581872e-01 0.182 0 0
Calcineurin activates NFAT R-HSA-2025928 6.581872e-01 0.182 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.581872e-01 0.182 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.581872e-01 0.182 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.581872e-01 0.182 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.581872e-01 0.182 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.581872e-01 0.182 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.581872e-01 0.182 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 6.581872e-01 0.182 0 0
Base Excision Repair R-HSA-73884 6.593003e-01 0.181 0 0
Signaling by WNT in cancer R-HSA-4791275 6.602170e-01 0.180 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.608458e-01 0.180 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 6.612068e-01 0.180 0 0
Signaling by FGFR4 R-HSA-5654743 6.682408e-01 0.175 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.710542e-01 0.173 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.751208e-01 0.171 0 0
Signalling to RAS R-HSA-167044 6.751208e-01 0.171 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.751208e-01 0.171 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.751208e-01 0.171 0 0
Basigin interactions R-HSA-210991 6.751208e-01 0.171 0 0
Signaling by FGFR1 R-HSA-5654736 6.766829e-01 0.170 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.796899e-01 0.168 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.799358e-01 0.168 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.822334e-01 0.166 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.828142e-01 0.166 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.874484e-01 0.163 0 0
DNA replication initiation R-HSA-68952 6.874484e-01 0.163 0 0
Folding of actin by CCT/TriC R-HSA-390450 6.874484e-01 0.163 0 0
Binding and entry of HIV virion R-HSA-173107 6.874484e-01 0.163 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.874484e-01 0.163 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.874484e-01 0.163 0 0
2-LTR circle formation R-HSA-164843 6.874484e-01 0.163 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.874484e-01 0.163 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.887159e-01 0.162 0 0
IRS-mediated signalling R-HSA-112399 6.895955e-01 0.161 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.935060e-01 0.159 0 0
Ribavirin ADME R-HSA-9755088 6.949495e-01 0.158 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.953602e-01 0.158 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.967168e-01 0.157 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.969318e-01 0.157 0 0
Signaling by FGFR3 R-HSA-5654741 6.969318e-01 0.157 0 0
Dual incision in TC-NER R-HSA-6782135 7.021524e-01 0.154 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.021524e-01 0.154 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.080927e-01 0.150 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.092013e-01 0.149 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.092013e-01 0.149 0 0
Dual Incision in GG-NER R-HSA-5696400 7.092013e-01 0.149 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.092013e-01 0.149 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.092013e-01 0.149 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.092013e-01 0.149 0 0
Mitophagy R-HSA-5205647 7.092013e-01 0.149 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 7.092013e-01 0.149 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.105932e-01 0.148 0 0
Diseases of DNA repair R-HSA-9675135 7.105932e-01 0.148 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.137659e-01 0.146 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.137659e-01 0.146 0 0
LDL clearance R-HSA-8964038 7.137659e-01 0.146 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.137659e-01 0.146 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 7.142063e-01 0.146 0 0
LGI-ADAM interactions R-HSA-5682910 7.142063e-01 0.146 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.142063e-01 0.146 0 0
vRNA Synthesis R-HSA-192814 7.142063e-01 0.146 0 0
Conjugation of benzoate with glycine R-HSA-177135 7.142063e-01 0.146 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.142063e-01 0.146 0 0
Bicarbonate transporters R-HSA-425381 7.142063e-01 0.146 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.142063e-01 0.146 0 0
Chylomicron assembly R-HSA-8963888 7.142063e-01 0.146 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.142063e-01 0.146 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.142063e-01 0.146 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.143520e-01 0.146 0 0
Platelet degranulation R-HSA-114608 7.226059e-01 0.141 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.237989e-01 0.140 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.242710e-01 0.140 0 0
Regulation of Apoptosis R-HSA-169911 7.242710e-01 0.140 0 0
Ca2+ pathway R-HSA-4086398 7.299609e-01 0.137 0 0
Growth hormone receptor signaling R-HSA-982772 7.315981e-01 0.136 0 0
PLC beta mediated events R-HSA-112043 7.376778e-01 0.132 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.386749e-01 0.132 0 0
ERKs are inactivated R-HSA-202670 7.386749e-01 0.132 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.386749e-01 0.132 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.386749e-01 0.132 0 0
Calmodulin induced events R-HSA-111933 7.387232e-01 0.132 0 0
CaM pathway R-HSA-111997 7.387232e-01 0.132 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.392393e-01 0.131 0 0
Infectious disease R-HSA-5663205 7.398076e-01 0.131 0 0
Leishmania phagocytosis R-HSA-9664417 7.445339e-01 0.128 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.445339e-01 0.128 0 0
Parasite infection R-HSA-9664407 7.445339e-01 0.128 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 7.484765e-01 0.126 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.484765e-01 0.126 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.484765e-01 0.126 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 7.484765e-01 0.126 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.488054e-01 0.126 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.501490e-01 0.125 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.506481e-01 0.125 0 0
Degradation of AXIN R-HSA-4641257 7.525676e-01 0.123 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.582327e-01 0.120 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.607115e-01 0.119 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.607115e-01 0.119 0 0
PI3K Cascade R-HSA-109704 7.607115e-01 0.119 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.610499e-01 0.119 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.610499e-01 0.119 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.610499e-01 0.119 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.610499e-01 0.119 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.610499e-01 0.119 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.610499e-01 0.119 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.610499e-01 0.119 0 0
Conjugation of salicylate with glycine R-HSA-177128 7.610499e-01 0.119 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.610499e-01 0.119 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.610499e-01 0.119 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.610499e-01 0.119 0 0
Diseases of programmed cell death R-HSA-9645723 7.627263e-01 0.118 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.644338e-01 0.117 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.644338e-01 0.117 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.658159e-01 0.116 0 0
Insulin receptor signalling cascade R-HSA-74751 7.700008e-01 0.114 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.721295e-01 0.112 0 0
Translation R-HSA-72766 7.726042e-01 0.112 0 0
Hedgehog 'off' state R-HSA-5610787 7.739803e-01 0.111 0 0
Stabilization of p53 R-HSA-69541 7.784807e-01 0.109 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.784807e-01 0.109 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.784807e-01 0.109 0 0
MET activates PTK2 signaling R-HSA-8874081 7.795039e-01 0.108 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.795039e-01 0.108 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.795039e-01 0.108 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.795039e-01 0.108 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.799969e-01 0.108 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.815104e-01 0.107 0 0
Chylomicron remodeling R-HSA-8963901 7.815104e-01 0.107 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.815104e-01 0.107 0 0
Maturation of nucleoprotein R-HSA-9683610 7.815104e-01 0.107 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.815104e-01 0.107 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.821178e-01 0.107 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.831146e-01 0.106 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.905761e-01 0.102 0 0
Diseases of Immune System R-HSA-5260271 7.905761e-01 0.102 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.905761e-01 0.102 0 0
Interleukin-2 family signaling R-HSA-451927 7.905761e-01 0.102 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.936741e-01 0.100 0 0
Signaling by BMP R-HSA-201451 7.937216e-01 0.100 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.937216e-01 0.100 0 0
DNA Double Strand Break Response R-HSA-5693606 7.991963e-01 0.097 0 0
G-protein mediated events R-HSA-112040 7.991963e-01 0.097 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.996569e-01 0.097 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.000708e-01 0.097 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.002199e-01 0.097 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.002199e-01 0.097 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.002199e-01 0.097 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.002199e-01 0.097 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.002199e-01 0.097 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.002199e-01 0.097 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.002199e-01 0.097 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.002199e-01 0.097 0 0
HDL assembly R-HSA-8963896 8.002199e-01 0.097 0 0
P2Y receptors R-HSA-417957 8.002199e-01 0.097 0 0
Zinc transporters R-HSA-435354 8.002199e-01 0.097 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.002199e-01 0.097 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.021168e-01 0.096 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.021168e-01 0.096 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.057198e-01 0.094 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.059201e-01 0.094 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.060964e-01 0.094 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.071225e-01 0.093 0 0
Pyroptosis R-HSA-5620971 8.071225e-01 0.093 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.075124e-01 0.093 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.125126e-01 0.090 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.125126e-01 0.090 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.131185e-01 0.090 0 0
Intra-Golgi traffic R-HSA-6811438 8.131185e-01 0.090 0 0
HDACs deacetylate histones R-HSA-3214815 8.135498e-01 0.090 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.153983e-01 0.089 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.173284e-01 0.088 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.173284e-01 0.088 0 0
Protein lipoylation R-HSA-9857492 8.173284e-01 0.088 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.173284e-01 0.088 0 0
Signaling by Activin R-HSA-1502540 8.173284e-01 0.088 0 0
p38MAPK events R-HSA-171007 8.173284e-01 0.088 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.173284e-01 0.088 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.173284e-01 0.088 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.173284e-01 0.088 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.197422e-01 0.086 0 0
Platelet calcium homeostasis R-HSA-418360 8.197422e-01 0.086 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.197422e-01 0.086 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.197422e-01 0.086 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.197422e-01 0.086 0 0
Post-translational protein modification R-HSA-597592 8.221889e-01 0.085 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.222857e-01 0.085 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.228839e-01 0.085 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.235974e-01 0.084 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.235974e-01 0.084 0 0
Depyrimidination R-HSA-73928 8.235974e-01 0.084 0 0
Ca-dependent events R-HSA-111996 8.235974e-01 0.084 0 0
COPII-mediated vesicle transport R-HSA-204005 8.253900e-01 0.083 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.294635e-01 0.081 0 0
DAP12 signaling R-HSA-2424491 8.316160e-01 0.080 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.316160e-01 0.080 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.316160e-01 0.080 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.329727e-01 0.079 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.329727e-01 0.079 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.329727e-01 0.079 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.329727e-01 0.079 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.329727e-01 0.079 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.329727e-01 0.079 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.329727e-01 0.079 0 0
Differentiation of T cells R-HSA-9945266 8.329727e-01 0.079 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.329727e-01 0.079 0 0
Negative regulation of FLT3 R-HSA-9706369 8.329727e-01 0.079 0 0
Meiosis R-HSA-1500620 8.368429e-01 0.077 0 0
Reproduction R-HSA-1474165 8.390501e-01 0.076 0 0
Stimuli-sensing channels R-HSA-2672351 8.395573e-01 0.076 0 0
Budding and maturation of HIV virion R-HSA-162588 8.427792e-01 0.074 0 0
Cargo concentration in the ER R-HSA-5694530 8.427792e-01 0.074 0 0
Proteasome assembly R-HSA-9907900 8.430535e-01 0.074 0 0
Surfactant metabolism R-HSA-5683826 8.430535e-01 0.074 0 0
Amine ligand-binding receptors R-HSA-375280 8.430535e-01 0.074 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.472781e-01 0.072 0 0
Glycine degradation R-HSA-6783984 8.472781e-01 0.072 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.472781e-01 0.072 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.472781e-01 0.072 0 0
Coenzyme A biosynthesis R-HSA-196783 8.472781e-01 0.072 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.472781e-01 0.072 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.472781e-01 0.072 0 0
Peroxisomal protein import R-HSA-9033241 8.485882e-01 0.071 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.520650e-01 0.070 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.520650e-01 0.070 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.520650e-01 0.070 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.532663e-01 0.069 0 0
tRNA Aminoacylation R-HSA-379724 8.564247e-01 0.067 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.603590e-01 0.065 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.603590e-01 0.065 0 0
Glycogen storage diseases R-HSA-3229121 8.603590e-01 0.065 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.603590e-01 0.065 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.606215e-01 0.065 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.606215e-01 0.065 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.631113e-01 0.064 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 8.631113e-01 0.064 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.631113e-01 0.064 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.631113e-01 0.064 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.631113e-01 0.064 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.639131e-01 0.064 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.710643e-01 0.060 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 8.723202e-01 0.059 0 0
Presynaptic function of Kainate receptors R-HSA-500657 8.723202e-01 0.059 0 0
Tie2 Signaling R-HSA-210993 8.723202e-01 0.059 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 8.723202e-01 0.059 0 0
Resolution of D-Loop Structures R-HSA-5693537 8.723472e-01 0.059 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.723472e-01 0.059 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.757975e-01 0.058 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.778891e-01 0.057 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.810060e-01 0.055 0 0
eNOS activation R-HSA-203615 8.810060e-01 0.055 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.810060e-01 0.055 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.810060e-01 0.055 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.815324e-01 0.055 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.832575e-01 0.054 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 8.832575e-01 0.054 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.832575e-01 0.054 0 0
Conjugation of carboxylic acids R-HSA-159424 8.832575e-01 0.054 0 0
Amino Acid conjugation R-HSA-156587 8.832575e-01 0.054 0 0
Translesion Synthesis by POLH R-HSA-110320 8.832575e-01 0.054 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.832575e-01 0.054 0 0
Specification of the neural plate border R-HSA-9834899 8.832575e-01 0.054 0 0
HDL remodeling R-HSA-8964058 8.832575e-01 0.054 0 0
Maturation of nucleoprotein R-HSA-9694631 8.832575e-01 0.054 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.832575e-01 0.054 0 0
Other interleukin signaling R-HSA-449836 8.832575e-01 0.054 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.832575e-01 0.054 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.837341e-01 0.054 0 0
Potential therapeutics for SARS R-HSA-9679191 8.839308e-01 0.054 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.843317e-01 0.053 0 0
Signaling by Hedgehog R-HSA-5358351 8.850099e-01 0.053 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.877073e-01 0.052 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.891188e-01 0.051 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.891188e-01 0.051 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.891188e-01 0.051 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.891188e-01 0.051 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.922303e-01 0.050 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.932585e-01 0.049 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 8.932585e-01 0.049 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 8.932585e-01 0.049 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 8.932585e-01 0.049 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 8.932585e-01 0.049 0 0
Glycogen synthesis R-HSA-3322077 8.932585e-01 0.049 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.932585e-01 0.049 0 0
Pregnenolone biosynthesis R-HSA-196108 8.932585e-01 0.049 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.967156e-01 0.047 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.967156e-01 0.047 0 0
Glycosphingolipid transport R-HSA-9845576 8.967156e-01 0.047 0 0
GPVI-mediated activation cascade R-HSA-114604 8.967156e-01 0.047 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.967156e-01 0.047 0 0
Cellular response to chemical stress R-HSA-9711123 8.970869e-01 0.047 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.971807e-01 0.047 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.971807e-01 0.047 0 0
Collagen formation R-HSA-1474290 9.020940e-01 0.045 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.024033e-01 0.045 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.024033e-01 0.045 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.024033e-01 0.045 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.024033e-01 0.045 0 0
ERK/MAPK targets R-HSA-198753 9.024033e-01 0.045 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.024033e-01 0.045 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.024033e-01 0.045 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.033649e-01 0.044 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.038252e-01 0.044 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.038252e-01 0.044 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.038252e-01 0.044 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.074995e-01 0.042 0 0
Regulated Necrosis R-HSA-5218859 9.074995e-01 0.042 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.086050e-01 0.042 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.104753e-01 0.041 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.104753e-01 0.041 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.104753e-01 0.041 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.104753e-01 0.041 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.107651e-01 0.041 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.107651e-01 0.041 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.107651e-01 0.041 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.107651e-01 0.041 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.140446e-01 0.039 0 0
Disease R-HSA-1643685 9.142391e-01 0.039 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.144269e-01 0.039 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.147343e-01 0.039 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.166924e-01 0.038 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.166924e-01 0.038 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.174365e-01 0.037 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.184110e-01 0.037 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.184110e-01 0.037 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.184110e-01 0.037 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.184110e-01 0.037 0 0
Hedgehog 'on' state R-HSA-5632684 9.220378e-01 0.035 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.225020e-01 0.035 0 0
Co-inhibition by PD-1 R-HSA-389948 9.231425e-01 0.035 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.234161e-01 0.035 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.254021e-01 0.034 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.254021e-01 0.034 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.254021e-01 0.034 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.254021e-01 0.034 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.254021e-01 0.034 0 0
Syndecan interactions R-HSA-3000170 9.254021e-01 0.034 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.279281e-01 0.032 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.279281e-01 0.032 0 0
Maturation of spike protein R-HSA-9694548 9.279281e-01 0.032 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.316985e-01 0.031 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.317946e-01 0.031 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.317946e-01 0.031 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.317946e-01 0.031 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.324784e-01 0.030 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.329937e-01 0.030 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.329937e-01 0.030 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.329937e-01 0.030 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.338942e-01 0.030 0 0
Toll-like Receptor Cascades R-HSA-168898 9.347244e-01 0.029 0 0
ER-Phagosome pathway R-HSA-1236974 9.370740e-01 0.028 0 0
PI Metabolism R-HSA-1483255 9.374249e-01 0.028 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.376397e-01 0.028 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 9.376397e-01 0.028 0 0
Tight junction interactions R-HSA-420029 9.376397e-01 0.028 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.376397e-01 0.028 0 0
Hyaluronan degradation R-HSA-2160916 9.376397e-01 0.028 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.376397e-01 0.028 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.376397e-01 0.028 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.376397e-01 0.028 0 0
Laminin interactions R-HSA-3000157 9.376397e-01 0.028 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.380204e-01 0.028 0 0
Downstream TCR signaling R-HSA-202424 9.404160e-01 0.027 0 0
Defective pyroptosis R-HSA-9710421 9.421304e-01 0.026 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.421304e-01 0.026 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.429841e-01 0.025 0 0
Metalloprotease DUBs R-HSA-5689901 9.429841e-01 0.025 0 0
Urea cycle R-HSA-70635 9.429841e-01 0.025 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.429841e-01 0.025 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.429841e-01 0.025 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.435359e-01 0.025 0 0
Opioid Signalling R-HSA-111885 9.435359e-01 0.025 0 0
DAP12 interactions R-HSA-2172127 9.462418e-01 0.024 0 0
Packaging Of Telomere Ends R-HSA-171306 9.478708e-01 0.023 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.478708e-01 0.023 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.478708e-01 0.023 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.478708e-01 0.023 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.478708e-01 0.023 0 0
Neutrophil degranulation R-HSA-6798695 9.488640e-01 0.023 0 0
Signaling by Insulin receptor R-HSA-74752 9.495041e-01 0.023 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.500740e-01 0.022 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.500740e-01 0.022 0 0
Somitogenesis R-HSA-9824272 9.500740e-01 0.022 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.522418e-01 0.021 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.523390e-01 0.021 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.523390e-01 0.021 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.523390e-01 0.021 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.523390e-01 0.021 0 0
Pyrimidine salvage R-HSA-73614 9.523390e-01 0.021 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.541362e-01 0.020 0 0
Ion transport by P-type ATPases R-HSA-936837 9.552991e-01 0.020 0 0
Parasitic Infection Pathways R-HSA-9824443 9.555595e-01 0.020 0 0
Leishmania infection R-HSA-9658195 9.555595e-01 0.020 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.564244e-01 0.019 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.564244e-01 0.019 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.564244e-01 0.019 0 0
DARPP-32 events R-HSA-180024 9.564244e-01 0.019 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.566118e-01 0.019 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.569700e-01 0.019 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.573157e-01 0.019 0 0
Transmission across Chemical Synapses R-HSA-112315 9.588086e-01 0.018 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.593155e-01 0.018 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.600662e-01 0.018 0 0
Metal ion SLC transporters R-HSA-425410 9.600662e-01 0.018 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.601598e-01 0.018 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.601598e-01 0.018 0 0
Neurotransmitter clearance R-HSA-112311 9.601598e-01 0.018 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.608552e-01 0.017 0 0
Formation of the cornified envelope R-HSA-6809371 9.627328e-01 0.016 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.635753e-01 0.016 0 0
Azathioprine ADME R-HSA-9748787 9.656296e-01 0.015 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.666981e-01 0.015 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.667694e-01 0.015 0 0
Protein localization R-HSA-9609507 9.685062e-01 0.014 0 0
Cardiogenesis R-HSA-9733709 9.695533e-01 0.013 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.702041e-01 0.013 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.704434e-01 0.013 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.704434e-01 0.013 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.704434e-01 0.013 0 0
Pyruvate metabolism R-HSA-70268 9.719357e-01 0.012 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.721639e-01 0.012 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.721639e-01 0.012 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.721639e-01 0.012 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.745509e-01 0.011 0 0
Hyaluronan metabolism R-HSA-2142845 9.745509e-01 0.011 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.745509e-01 0.011 0 0
Signal amplification R-HSA-392518 9.745509e-01 0.011 0 0
Mitochondrial biogenesis R-HSA-1592230 9.761139e-01 0.010 0 0
Interferon gamma signaling R-HSA-877300 9.764214e-01 0.010 0 0
G alpha (z) signalling events R-HSA-418597 9.764654e-01 0.010 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.767332e-01 0.010 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.767332e-01 0.010 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.767332e-01 0.010 0 0
PERK regulates gene expression R-HSA-381042 9.767332e-01 0.010 0 0
Ion channel transport R-HSA-983712 9.781470e-01 0.010 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.787285e-01 0.009 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.787285e-01 0.009 0 0
Triglyceride catabolism R-HSA-163560 9.787285e-01 0.009 0 0
Synthesis of PA R-HSA-1483166 9.798010e-01 0.009 0 0
Voltage gated Potassium channels R-HSA-1296072 9.805529e-01 0.009 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.805529e-01 0.009 0 0
Cleavage of the damaged purine R-HSA-110331 9.805529e-01 0.009 0 0
NCAM1 interactions R-HSA-419037 9.805529e-01 0.009 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.805529e-01 0.009 0 0
Collagen chain trimerization R-HSA-8948216 9.805529e-01 0.009 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.807878e-01 0.008 0 0
Translation of Structural Proteins R-HSA-9694635 9.814716e-01 0.008 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.822084e-01 0.008 0 0
Depurination R-HSA-73927 9.822208e-01 0.008 0 0
Purine salvage R-HSA-74217 9.822208e-01 0.008 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.826761e-01 0.008 0 0
Cholesterol biosynthesis R-HSA-191273 9.827133e-01 0.008 0 0
ABC transporter disorders R-HSA-5619084 9.827133e-01 0.008 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.838751e-01 0.007 0 0
RAB geranylgeranylation R-HSA-8873719 9.839605e-01 0.007 0 0
Metabolism of polyamines R-HSA-351202 9.839605e-01 0.007 0 0
Adaptive Immune System R-HSA-1280218 9.849583e-01 0.007 0 0
Glycogen metabolism R-HSA-8982491 9.851401e-01 0.007 0 0
Tryptophan catabolism R-HSA-71240 9.851401e-01 0.007 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.860352e-01 0.006 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.864148e-01 0.006 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.864148e-01 0.006 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.864148e-01 0.006 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.867373e-01 0.006 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.875803e-01 0.005 0 0
Translation of Structural Proteins R-HSA-9683701 9.875803e-01 0.005 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.878169e-01 0.005 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.886459e-01 0.005 0 0
ABC-family proteins mediated transport R-HSA-382556 9.892796e-01 0.005 0 0
Pyrimidine catabolism R-HSA-73621 9.896200e-01 0.005 0 0
Hemostasis R-HSA-109582 9.897878e-01 0.004 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.901467e-01 0.004 0 0
Cardiac conduction R-HSA-5576891 9.904750e-01 0.004 0 0
Methylation R-HSA-156581 9.905107e-01 0.004 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.906868e-01 0.004 0 0
Kidney development R-HSA-9830369 9.906868e-01 0.004 0 0
Neddylation R-HSA-8951664 9.907165e-01 0.004 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.908231e-01 0.004 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.920694e-01 0.003 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.920694e-01 0.003 0 0
Synthesis of PC R-HSA-1483191 9.927500e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.931071e-01 0.003 0 0
Metabolism of cofactors R-HSA-8978934 9.931952e-01 0.003 0 0
Neuronal System R-HSA-112316 9.932116e-01 0.003 0 0
Platelet homeostasis R-HSA-418346 9.932651e-01 0.003 0 0
GPER1 signaling R-HSA-9634597 9.933723e-01 0.003 0 0
Immune System R-HSA-168256 9.937053e-01 0.003 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.939411e-01 0.003 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.939411e-01 0.003 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.944612e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.946295e-01 0.002 0 0
Meiotic recombination R-HSA-912446 9.949366e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.949366e-01 0.002 0 0
The phototransduction cascade R-HSA-2514856 9.949366e-01 0.002 0 0
Metabolism of proteins R-HSA-392499 9.955227e-01 0.002 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.957687e-01 0.002 0 0
Nucleotide biosynthesis R-HSA-8956320 9.957687e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.960897e-01 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.961527e-01 0.002 0 0
Regulation of insulin secretion R-HSA-422356 9.966673e-01 0.001 0 0
Digestion R-HSA-8935690 9.967677e-01 0.001 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.967677e-01 0.001 0 0
Amyloid fiber formation R-HSA-977225 9.969214e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.970453e-01 0.001 0 0
Triglyceride metabolism R-HSA-8979227 9.975310e-01 0.001 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.975785e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.977430e-01 0.001 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.977430e-01 0.001 0 0
Integration of energy metabolism R-HSA-163685 9.977956e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.979369e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.979369e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.979369e-01 0.001 0 0
Metabolism of nucleotides R-HSA-15869 9.980181e-01 0.001 0 0
Mitochondrial protein import R-HSA-1268020 9.981141e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.982468e-01 0.001 0 0
Digestion and absorption R-HSA-8963743 9.982761e-01 0.001 0 0
Xenobiotics R-HSA-211981 9.984242e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.987965e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.988999e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.990033e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.990808e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.991598e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.991598e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.991598e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.992517e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.992517e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.992801e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.992981e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.992981e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.993335e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.993572e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.994135e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.994365e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.995522e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.995802e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.995907e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.996580e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.997010e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.997897e-01 0.000 0 0
Keratinization R-HSA-6805567 9.997960e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.998007e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998822e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999113e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999321e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999323e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999618e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999672e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999672e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999699e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999825e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999895e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999937e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999942e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999952e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999965e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999976e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999983e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999990e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999990e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999990e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999997e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999998e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999998e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999999e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways