MNK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

Log-Odds: S Sites / S Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A6NKT7	S980	Sugiyama	RGPD3 RGP3	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O00571	S83	Sugiyama	DDX3X DBX DDX3	sKDKDAyssFGsRsDsRGKssFFsDRGsGsRGRFDDRGRsD
O14641	T652	Sugiyama	DVL2	RRGGEAsGtsDGGPPPsRGstGGAPNLRAHPGLHPYGPPPG
O14715	S979	Sugiyama	RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
O14974	S445	Sugiyama	PPP1R12A MBS MYPT1	EEERKDEsPATWRLGLRKtGsyGALAEItASKEGQKEKDTA
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O43597	S112	EPSD\|PSP	SPRY2	PRLQHSQVHSSARAPLSRSIsTVsSGSRSsTRTSTSSSSSE
O43597	S121	EPSD\|PSP	SPRY2	SSARAPLSRSIsTVsSGSRSsTRTSTSSSSSEQRLLGssFs
O60664	S175	Sugiyama	PLIN3 M6PRBP1 TIP47	RGAVQSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVDtVLGK
O60664	S93	Sugiyama	PLIN3 M6PRBP1 TIP47	AAVsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQP
O60814	S37	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814	S39	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841	S107	Sugiyama	EIF5B IF2 KIAA0741	NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75348	S68	Sugiyama	ATP6V1G1 ATP6G ATP6G1 ATP6J	RLQREKEFKAKEAAALGsRGsCstEVEKETQEKMTILQtyF
O75534	S584	Sugiyama	CSDE1 D1S155E KIAA0885 NRU UNR	YSLSKGKGNKVSAEKVNKtHsVNGItEEADPTIysGKVIRP
O76070	S9	Sugiyama	SNCG BCSG1 PERSYN PRSN	____________MDVFKKGFsIAKEGVVGAVEKTKQGVTEA
O95218	S143	Sugiyama	ZRANB2 ZIS ZNF265	EyDEFGRKKKKYRGKAVGPAsILKEVEDKEsEGEEEDEDED
O95218	S153	Sugiyama	ZRANB2 ZIS ZNF265	KYRGKAVGPAsILKEVEDKEsEGEEEDEDEDLsKyKLDEDE
O95297	S260	Sugiyama	MPZL1 PZR UNQ849/PRO1787	IyAQLDHsGGHHSDKINKSEsVVyADIRKN___________
O95678	S162	Sugiyama	KRT75 K6HF KB18	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95757	S587	Sugiyama	HSPA4L APG1 HSPH3 OSP94	RLNQTLKKGKVKsIDLPIQssLCRQLGQDLLNsyIENEGKM
O96013	S41	Sugiyama	PAK4 KIAA1142	VHTGFDQHEQKFTGLPRQWQsLIEESARRPKPLVDPACITS
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00558	S390	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	IIGGGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPG
P00558	S399	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P02538	S176	Sugiyama	KRT6A K6A KRT6D	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075	S17	Sugiyama	ALDOA ALDA	____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst
P04075	S356	Sugiyama	ALDOA ALDA	sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083	S173	Sugiyama	ANXA1 ANX1 LPC1	NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04259	S176	Sugiyama	KRT6B K6B KRTL1	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406	S151	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	FVMGVNHEKYDNSLKIIsNAsCttNCLAPLAKVIHDNFGIV
P04406	S210	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	S312	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA
P04792	S15	Sugiyama	HSPB1 HSP27 HSP28	______MTERRVPFsLLRGPsWDPFRDWyPHsRLFDQAFGL
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792	S86	Sugiyama	HSPB1 HSP27 HSP28	PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP
P05362	S43	Sugiyama	ICAM1	GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05787	S104	Sugiyama	KRT8 CYK8	IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787	S410	Sugiyama	KRT8 CYK8	TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL
P06730	S209	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	EIF4E EIF4EL1 EIF4F	LPPKIVIGyQsHADTAtKsGsttKNRFVV____________
P06733	S27	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733	S349	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	AKAVNEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMV
P06733	S353	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NEKsCNCLLLKVNQIGsVTEsLQACKLAQANGWGVMVsHRs
P06733	S40	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK
P06899	S39	Sugiyama	H2BC11 H2BFR HIST1H2BJ	VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07205	S390	Sugiyama	PGK2 PGKB	VIGGGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPG
P07205	S399	Sugiyama	PGK2 PGKB	CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07602	S29	Sugiyama	PSAP GLBA SAP1	SLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVKHCL
P07711	S301	Sugiyama	CTSL CTSL1	VGYGFESTESDNNKYWLVKNsWGEEWGMGGyVKMAKDRRNH
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814	S330	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	KHRKNPIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGC
P07814	S335	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07814	S739	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S53	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900	S641	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	S470	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs
P08238	S48	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238	S482	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	sGDEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVER
P08238	S497	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08238	Y457	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P08729	S104	Sugiyama	KRT7 SCL	LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P08758	T10	Sugiyama	ANXA5 ANX5 ENX2 PP4	___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P09382	S63	Sugiyama	LGALS1	CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09651	S192	GPS6\|EPSD	HNRNPA1 HNRPA1	GHNCEVRKALSKQEMAsAsssQRGRsGsGNFGGGRGGGFGG
P09651	S362	GPS6\|EPSD	HNRNPA1 HNRPA1	GGGGQyFAKPRNQGGyGGssssssyGsGRRF__________
P09651	S363	GPS6\|EPSD	HNRNPA1 HNRPA1	GGGQyFAKPRNQGGyGGssssssyGsGRRF___________
P09651	S364	GPS6\|EPSD	HNRNPA1 HNRPA1	GGQyFAKPRNQGGyGGssssssyGsGRRF____________
P09972	S17	Sugiyama	ALDOC ALDC	____MPHSYPALSAEQKKELsDIALRIVAPGKGILAADEsV
P09972	S45	Sugiyama	ALDOC ALDC	APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DJD0	S964	Sugiyama	RGPD1 RANBP2L6 RGP1	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412	S58	Sugiyama	H1-4 H1F4 HIST1H1E	PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P12004	S152	Sugiyama	PCNA	EySCVVKMPSGEFARICRDLsHIGDAVVIsCAKDGVKFSAs
P12004	S161	Sugiyama	PCNA	SGEFARICRDLsHIGDAVVIsCAKDGVKFSAsGELGNGNIK
P12035	S211	Sugiyama	KRT3	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639	S38	Sugiyama	EEF2 EF2	NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13647	S181	Sugiyama	KRT5	IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13667	S126	Sugiyama	PDIA4 ERP70 ERP72	NILKDKDPPIPVAKIDAtsAsVLAsRFDVsGyPtIKILKKG
P13797	S540	Sugiyama	PLS3	NDDIIVNWVNRTLSEAGKSTsIQSFKDKTISSSLAVVDLID
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P13984	S28	Sugiyama	GTF2F2 RAP30	DLTGAKQNtGVWLVKVPKYLsQQWAKASGRGEVGKLRIAKT
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14314	S478	Sugiyama	PRKCSH G19P1	DKFSAMKyEQGtGCWQGPNRstTVRLLCGKEtMVtStTEPS
P14618	S97	Sugiyama	PKM OIP3 PK2 PK3 PKM2	sHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGP
P14625	S109	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625	S172	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI
P14625	S514	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625	S515	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQ
P14625	S64	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625	S674	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	WsGNMERIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLI
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311	S539	Sugiyama	EZR VIL2	TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15328	S79	Sugiyama	FOLR1 FOLR	PWRKNACCSTNTSQEAHKDVsyLyRFNWNHCGEMAPACKRH
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15880	S249	Sugiyama	RPS2 RPS4	CtAtLGNFAKATFDAISKTysyLtPDLWKEtVFtKsPyQEF
P15880	T202	Sugiyama	RPS2 RPS4	CKVTGRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDC
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402	S59	Sugiyama	H1-3 H1F3 HIST1H1D	PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	S58	Sugiyama	H1-2 H1F2 HIST1H1C	PPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEKNNS
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17987	S374	Sugiyama	TCP1 CCT1 CCTA	ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P18615	S113	Sugiyama	NELFE RD RDBP	EGKLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLy
P18615	S131	Sugiyama	NELFE RD RDBP	QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P18669	S14	Sugiyama	PGAM1 PGAMA CDABP0006	_______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P19338	S328	Sugiyama	NCL	NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338	S458	Sugiyama	NCL	TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338	Y462	Sugiyama	NCL	AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P20290	S173	Sugiyama	BTF3 NACB OK/SW-cl.8	QLGADsLtsLRRLAEALPKQsVDGKAPLAtGEDDDDEVPDL
P21333	S1029	Sugiyama	FLNA FLN FLN1	VGPSGAAVPCKVEPGLGADNsVVRFLPREEGPYEVEVTYDG
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626	S225	Sugiyama	HNRNPA2B1 HNRPA2B1	GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P23246	S283	EPSD\|PSP\|Sugiyama	SFPQ PSF	GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN
P23246	S8	EPSD\|PSP	SFPQ PSF	_____________MSRDRFRsRGGGGGGFHRRGGGGGRGGL
P23527	S39	Sugiyama	H2BC17 H2BFH H2BFN HIST1H2BO	VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P23528	S41	Sugiyama	CFL1 CFL	RKsstPEEVKKRKKAVLFCLsEDKKNIILEEGKEILVGDVG
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P24534	S141	Sugiyama	EEF1B2 EEF1B EF1B	ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P24752	S218	Sugiyama	ACAT1 ACAT MAT	ENTAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPV
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25205	S447	Sugiyama	MCM3	EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25398	S107	Sugiyama	RPS12	EWVGLCKIDREGKPRKVVGCsCVVVKDYGKESQAKDVIEEy
P25705	S198	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	GIIPRIsVREPMQTGIKAVDsLVPIGRGQRELIIGDRQTGK
P25789	T10	Sugiyama	PSMA4 HC9 PSC9	___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P26038	S429	Sugiyama	MSN	DQKKTQEQLALEMAELtARIsQLEMARQKKEsEAVEWQQKA
P26038	S527	Sugiyama	MSN	ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26639	S282	Sugiyama	TARS1 TARS	RGPHVRHTGKIKALKIHKNssTyWEGKADMETLQRIyGISF
P26641	T287	Sugiyama	EEF1G EF1G PRO1608	EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27708	S1859	Sugiyama	CAD	RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29401	S443	Sugiyama	TKT	EDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAAN
P29692	S60	Sugiyama	EEF1D EF1D	ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30086	S54	Sugiyama	PEBP1 PBP PEBP	VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP
P30622	S193	Sugiyama	CLIP1 CYLN1 RSN	QPAAKEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELK
P30622	S195	Sugiyama	CLIP1 CYLN1 RSN	AAKEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELKIG
P31939	S202	Sugiyama	ATIC PURH OK/SW-cl.86	tAQyDEAISDyFRKQYSKGVsQMPLRyGMNPHQtPAQLytL
P32119	S112	Sugiyama	PRDX2 NKEFB TDPX1	KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P33316	S120	Sugiyama	DUT	PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33316	S164	Sugiyama	DUT	YTIPPMEKAVVKTDIQIALPsGCyGRVAPRSGLAAKHFIDV
P33778	S39	Sugiyama	H2BC3 H2BFF HIST1H2BB	ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932	S363	Sugiyama	HSPA4 APG2 HSPH2	GATRIPAVKEKISKFFGKELsttLNADEAVTRGCALQCAIL
P35241	S532	Sugiyama	RDX	EERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHA
P35241	S533	Sugiyama	RDX	ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35613	S279	Sugiyama	BSG UNQ6505/PRO21383	TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P35637	S462	Sugiyama	FUS TLS	NECNQCKAPKPDGPGGGPGGsHMGGNyGDDRRGGRGGYDRG
P35908	S191	Sugiyama	KRT2 KRT2A KRT2E	IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P36578	S63	Sugiyama	RPL4 RPL1	NLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGG
P36578	S87	Sugiyama	RPL4 RPL1	WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P37108	S25	Sugiyama	SRP14	EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646	T120	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646	Y118	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P39023	S304	Sugiyama	RPL3 OK/SW-cl.32	IYKIGQGyLIKDGKLIKNNAstDyDLSDKSINPLGGFVHYG
P39748	S255	Sugiyama	FEN1 RAD2	CESIRGIGPKRAVDLIQKHKsIEEIVRRLDPNKYPVPENWL
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P43490	S472	Sugiyama	NAMPT PBEF PBEF1	EYGQDLLHTVFKNGKVTKsysFDEIRKNAQLNIELEAAHH_
P46060	S24	Sugiyama	RANGAP1 KIAA1835 SD	EDIAKLAETLAKTQVAGGQLsFKGKSLKLNTAEDAKDVIKE
P46060	S454	Sugiyama	RANGAP1 KIAA1835 SD	VstFLAFPsPEKLLRLGPKssVLIAQQTDTSDPEKVVSAFL
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777	S172	Sugiyama	RPL5 MSTP030	RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777	S176	Sugiyama	RPL5 MSTP030	GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46937	S109	Sugiyama	YAP1 YAP65	RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P46937	T114	Sugiyama	YAP1 YAP65	sFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssPAsLQL
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48643	S270	Sugiyama	CCT5 CCTE KIAA0098	ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ
P48668	S176	Sugiyama	KRT6C KRT6E	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49588	S775	Sugiyama	AARS1 AARS	VTGAEAQKALRKAESLKKCLsVMEAKVKAQTAPNKDVQREI
P49790	S607	Sugiyama	NUP153	KtPPEDCEGPFRPAEILKEGsVLDILKsPGFAsPKIDSVAA
P49792	S1955	Sugiyama	RANBP2 NUP358	GVIFGQTSSTFTFADLAKstsGEGFQFGKKDPNFKGFSGAG
P50395	S396	Sugiyama	GDI2 RABGDIB	IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50454	S139	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53634	S428	Sugiyama	CTSC CPPI	LLVGYGTDSASGMDYWIVKNsWGtGWGENGyFRIRRGtDEC
P53999	S57	Sugiyama	SUB1 PC4 RPO2TC1	VKKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRDF
P54577	S338	Sugiyama	YARS1 YARS	NKLLDPIREKFNTPALKKLAsAAYPDPSKQKPMAKGPAKNs
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55036	S266	Sugiyama	PSMD4 MCB1	AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55735	S184	Sugiyama	SEC13 D3S1231E SEC13A SEC13L1 SEC13R	PGsLIDHPSGQKPNYIKRFAsGGCDNLIKLWKEEEDGQWKE
P55854	S27	Sugiyama	SUMO3 SMT3A SMT3H1	KEGVKTENDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P57053	S37	Sugiyama	H2BC12L H2BFS H2BS1	KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053	S39	Sugiyama	H2BC12L H2BFS H2BS1	VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876	S37	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876	S39	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	Y53	Sugiyama	ACTB	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61081	S175	Sugiyama	UBE2M UBC12	NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61247	S236	Sugiyama	RPS3A FTE1 MFTL	KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247	S237	Sugiyama	RPS3A FTE1 MFTL	MLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyE
P61313	S100	Sugiyama	RPL15 EC45 TCBAP0781	tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61313	S97	Sugiyama	RPL15 EC45 TCBAP0781	KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61353	S86	Sugiyama	RPL27	SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61604	S51	Sugiyama	HSPE1	IMLPEKSQGKVLQAtVVAVGsGsKGKGGEIQPVsVKVGDKV
P61956	S28	Sugiyama	SUMO2 SMT3B SMT3H2	EGVKtENNDHINLKVAGQDGsVVQFKIKRHTPLSKLMKAYC
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61978	T70	Sugiyama	HNRNPK HNRPK	QSKNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsI
P62072	S48	Sugiyama	TIMM10 TIM10	ACHRKCVPPHYKEAELSKGEsVCLDRCVSKYLDIHERMGKK
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62263	S139	Sugiyama	RPS14 PRO2640	LARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL________
P62269	S96	Sugiyama	RPS18 D6S218E	QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62269	Y95	Sugiyama	RPS18 D6S218E	RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62701	T247	Sugiyama	RPS4X CCG2 RPS4 SCAR	VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62714	S43	Sugiyama	PPP2CB	LNENQVRTLCEKAKEILTKEsNVQEVRCPVTVCGDVHGQFH
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	Y55	Sugiyama	ACTA2 ACTSA ACTVS GIG46	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62807	S37	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807	S39	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62857	S41	Sugiyama	RPS28	tGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtLLEs
P62899	S15	Sugiyama	RPL31	______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917	S130	Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917	S138	Sugiyama	RPL8	EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917	S14	Sugiyama	RPL8	_______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62917	T146	Sugiyama	RPL8	LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	Y53	Sugiyama	ACTG1 ACTG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	Y54	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67775	S43	Sugiyama	PPP2CA	LSESQVKSLCEKAKEILTKEsNVQEVRCPVTVCGDVHGQFH
P67809	S102	Sugiyama	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809	S136	Sugiyama	YBX1 NSEP1 YB1	GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	Y55	Sugiyama	ACTC1 ACTC	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104	S175	Sugiyama	EEF1A1 EEF1A EF1A LENG7	MDSTEPPySQKRYEEIVKEVsTyIKKIGYNPDTVAFVPISG
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	Y55	Sugiyama	ACTA1 ACTA	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P78345	S253	Sugiyama	RPP38	DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P78371	S60	Sugiyama	CCT2 99D8.1 CCTB	KSTLGPKGMDKILLsSGRDAsLMVtNDGAtILKNIGVDNPA
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731	S9	Sugiyama	RPL24	____________MKVELCsFsGyKIYPGHGRRYARTDGKVF
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00341	S904	Sugiyama	HDLBP HBP VGL	FHRSVMGPKGSRIQQITRDFsVQIKFPDREENAVHSTEPVV
Q00587	S192	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	PHDRDRDGsFPsEPGLRRsDsLLsFRLDLDLGPSLLSELLG
Q00610	S146	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	AVYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLL
Q00839	S267	Sugiyama	HNRNPU C1orf199 HNRPU SAFA U21.1	KRPREDHGRGyFEyIEENKysRAKsPQPPVEEEDEHFDDtV
Q01105	S161	Sugiyama	SET	FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105	S166	Sugiyama	SET	yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105	T169	Sugiyama	SET	NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01546	S196	Sugiyama	KRT76 KRT2B KRT2P	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q01650	S31	Sugiyama	SLC7A5 CD98LC LAT1 MPE16	LAAPAAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNIT
Q02878	S255	Sugiyama	RPL6 TXREB1	tEKEKYEITEQRKIDQKAVDsQILPKIKAIPQLQGYLRSVF
Q06210	T263	Sugiyama	GFPT1 GFAT GFPT	QGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDASA
Q06830	S32	Sugiyama	PRDX1 PAGA PAGB TDPX2	APNFKAtAVMPDGQFKDIsLsDyKGKYVVFFFYPLDFTFVC
Q07352	S84	Sugiyama	ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B	QNQLLSsLKGEPAPALSSRDsRFRDRsFsEGGERLLPTQKQ
Q07666	S20	Sugiyama	KHDRBS1 SAM68	_MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q09028	S146	Sugiyama	RBBP4 RBAP48	EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q12965	S1002	Sugiyama	MYO1E MYO1C	RSNQKSLyTsMARPPLPRQQstssDRVsQtPEsLDFLKVPD
Q13263	S138	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	PVCKQQCFSKDIVENyFMRDsGsKAATDAQDANQCCTSCED
Q13283	S67	Sugiyama	G3BP1 G3BP	sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13573	S182	Sugiyama	SNW1 SKIIP SKIP	AMPVRAADKLAPAQyIRytPsQQGVAFNsGAKQRVIRMVEM
Q14247	S332	Sugiyama	CTTN EMS1	VQKDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKtsNIRA
Q14568	S53	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14677	S166	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14847	S99	Sugiyama	LASP1 MLN50	ELQsQVRYKEEFEKNKGKGFsVVADtPELQRIKKTQDQIsN
Q14980	S1181	Sugiyama	NUMA1 NMP22 NUMA	DsALEtLQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQD
Q14980	S1183	Sugiyama	NUMA1 NMP22 NUMA	ALEtLQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQDHS
Q14CN4	S138	Sugiyama	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15149	S4642	EPSD\|PSP	PLEC PLEC1	stAGsRtGsRtGsRAGsRRGsFDAtGsGFsMtFSsssYSSS
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15185	S82	Sugiyama	PTGES3 P23 TEBP	NDsKHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVD
Q15185	S85	Sugiyama	PTGES3 P23 TEBP	KHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVDFNN
Q15398	S15	Sugiyama	DLGAP5 DLG7 KIAA0008	______MSSSHFASRHRKDIsTEMIRTKIAHRKSLSQKENR
Q15417	S259	Sugiyama	CNN3	DNSTISLQMGTNKVAsQKGMsVyGLGRQVYDPKYCAAPTEP
Q16576	S145	Sugiyama	RBBP7 RBAP46	EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16778	S39	Sugiyama	H2BC21 H2BFQ HIST2H2BE	VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q3KQU3	S112	Sugiyama	MAP7D1 KIAA1187 PARCC1 RPRC1 PP2464	KsRGPtPPAMGPRDARPPRRssQPsPtAVPAsDsPPtKQEV
Q3SY84	S143	Sugiyama	KRT71 K6IRS1 KB34 KRT6IRS1	IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q58FF7	S370	Sugiyama	HSP90AB3P HSP90BC	KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q58FF8	S258	Sugiyama	HSP90AB2P HSP90BB	LAVRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQ
Q5QNW6	S37	Sugiyama	H2BC18 HIST2H2BF	KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6	S39	Sugiyama	H2BC18 HIST2H2BF	VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5SW79	S873	Sugiyama	CEP170 FAM68A KAB KIAA0470	IPHINKQTsstPssLALtsAsRIRERsEsLDPDssMDTtLI
Q5SYE7	S1495	Sugiyama	NHSL1 C6orf63 KIAA1357	KNRRAQEEWAKNEGLMPRsLsFsGPRYGRSRTPPSAASSRY
Q5VTE0	S175	Sugiyama	EEF1A1P5 EEF1AL3	MDSTEPPySQKRYEEIVKEVsTyIKKIGYNPDTVAFVPISG
Q5XKE5	S155	Sugiyama	KRT79 K6L KB38 KRT6L	IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6DN03	S39	Sugiyama	H2BC20P HIST2H2BC	VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6	S39	Sugiyama	H2BC19P HIST2H2BD	VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6EEV6	S28	Sugiyama	SUMO4 SMT3H4	EEVKTENNNHINLKVAGQDGsVVQFKIKRQTPLSKLMKAYC
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q7RTS7	S153	Sugiyama	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z3J3	S980	Sugiyama	RGPD4 RGP4	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDPNFKGFSGAG
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z460	S545	Sugiyama	CLASP1 KIAA0622 MAST1	yHTLESSyQKALQSHLKNSDsIVsLPQsDRsssssQEsLNR
Q7Z5L9	S455	Sugiyama	IRF2BP2	AGGSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVG
Q7Z5L9	S457	Sugiyama	IRF2BP2	GSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVGGQ
Q7Z794	S177	Sugiyama	KRT77 KRT1B	IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86V48	S878	Sugiyama	LUZP1	AERMADGPLKDRPETVVSRssIIIKPSDPVERNSHAPPAET
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46	S145	Sugiyama	KRT73 K6IRS3 KB36 KRT6IRS3	IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IZ21	S590	Sugiyama	PHACTR4 PRO2963	SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8N201	S495	Sugiyama	INTS1 KIAA1440 UNQ1821/PRO3434	KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N257	S39	Sugiyama	H2BC26 H2BU1 HIST3H2BB	VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8N684	S166	Sugiyama	CPSF7	PGKVLNGEKVDVRPAtRQNLsQFEAQARKRECVRVPRGGIP
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBP7	S487	Sugiyama	PCSK9 NARC1 PSEC0052	PTRMATAVARCAPDEELLsCssFSRSGKRRGERMEAQGGKL
Q8NBS9	S292	Sugiyama	TXNDC5 TLP46 UNQ364/PRO700	KKVDQYKGKRDLEsLREyVEsQLQRTETGATETVTPSEAPV
Q8NEZ2	S18	Sugiyama	VPS37A HCRP1	___MSWLFPLTKsAsssAAGsPGGLTSLQQQKQRLIESLRN
Q8TD47	T247	Sugiyama	RPS4Y2 RPS4Y2P	VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q92945	S333	Sugiyama	KHSRP FUBP2	DRNEyGsRIGGGIDVPVPRHsVGVVIGRSGEMIKKIQNDAG
Q93079	S37	Sugiyama	H2BC9 H2BFJ HIST1H2BH	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079	S39	Sugiyama	H2BC9 H2BFJ HIST1H2BH	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q969S3	S38	Sugiyama	ZNF622 ZPR9	MQRAHYKTDWHRYNLRRKVAsMAPVTAEGFQERVRAQRAVA
Q96G46	T240	Sugiyama	DUS3L	KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96G46	T273	Sugiyama	DUS3L	GAPRQENCGAQQVPAGPGtstPPssPVRtCGPLtDEDVVRL
Q96GQ7	S79	Sugiyama	DDX27 cPERP-F RHLP HSPC259 PP3241	EEEEGPIVLGRRQKALGKNRsADFNPDFVFTEKEGTyDGsW
Q96HE7	S143	Sugiyama	ERO1A ERO1L UNQ434/PRO865	EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96IZ0	S231	Sugiyama	PAWR PAR4	SsyLLQEPPRTVSGRyKsttsVsEEDVsSRYsRTDRSGFPR
Q96IZ0	Y226	Sugiyama	PAWR PAR4	LLDPGSsyLLQEPPRTVSGRyKsttsVsEEDVsSRYsRTDR
Q96PE3	S788	Sugiyama	INPP4A	FNVRVPLPGPLFDALPREIQsGMLLRVQPVLFNVGINEQQT
Q99575	S816	Sugiyama	POP1 KIAA0061	VAATGSHLCVLRSRKLLKQLsAWCGPSSEDSRGGRRAPGRG
Q99666	S979	Sugiyama	RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6	GVIFGQTSSTFTFADVAKstsGEGFQFGKKDLNFKGFSGAG
Q99733	S53	Sugiyama	NAP1L4 NAP2	QNPRVLAALQERLDNVPHtPssyIEtLPKAVKRRINALKQL
Q99877	S37	Sugiyama	H2BC15 H2BFD HIST1H2BN	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877	S39	Sugiyama	H2BC15 H2BFD HIST1H2BN	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879	S37	Sugiyama	H2BC14 H2BFE HIST1H2BM	KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879	S39	Sugiyama	H2BC14 H2BFE HIST1H2BM	INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880	S37	Sugiyama	H2BC13 H2BFC HIST1H2BL	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880	S39	Sugiyama	H2BC13 H2BFC HIST1H2BL	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BT09	S205	Sugiyama	CNPY3 CTG4A ERDA5 PRAT4A TNRC5 HSPC084 UNQ1934/PRO4409	QEEDLTEFLCANHVLKGKDtsCLAEQWsGKKGDTAALGGKK
Q9BY44	S526	Sugiyama	EIF2A CDA02 MSTP004 MSTP089	sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9H788	S315	Sugiyama	SH2D4A PPP1R38 SH2A	LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H788	Y131	Sugiyama	SH2D4A PPP1R38 SH2A	EEPRKTHsEEFTNsLKTKsQyHDLQAPDNQQtKDIWKKVAE
Q9HBH9	S166	Sugiyama	MKNK2 GPRK7 MNK2	IEFFEEEDRFYLVFEKMRGGsILSHIHKRRHFNELEASVVV
Q9HBH9	S338	Sugiyama	MKNK2 GPRK7 MNK2	LFESIQEGKYEFPDKDWAHIsCAAKDLISKLLVRDAKQRLS
Q9HBH9	S394	Sugiyama	MKNK2 GPRK7 MNK2	ENTLPTPMVLQRNSCAKDLTsFAAEAIAMNRQLAQHDEDLA
Q9HBH9	S431	Sugiyama	MKNK2 GPRK7 MNK2	EDLAEEEAAGQGQPVLVRAtsRCLQLsPPsQsKLAQRRQRA
Q9HBH9	S437	Sugiyama	MKNK2 GPRK7 MNK2	EAAGQGQPVLVRAtsRCLQLsPPsQsKLAQRRQRAsLssAP
Q9HBH9	S440	Sugiyama	MKNK2 GPRK7 MNK2	GQGQPVLVRAtsRCLQLsPPsQsKLAQRRQRAsLssAPVVL
Q9HBH9	S442	Sugiyama	MKNK2 GPRK7 MNK2	GQPVLVRAtsRCLQLsPPsQsKLAQRRQRAsLssAPVVLVG
Q9HBH9	S452	Sugiyama	MKNK2 GPRK7 MNK2	RCLQLsPPsQsKLAQRRQRAsLssAPVVLVGDHA_______
Q9HBH9	S454	Sugiyama	MKNK2 GPRK7 MNK2	LQLsPPsQsKLAQRRQRAsLssAPVVLVGDHA_________
Q9HBH9	S455	Sugiyama	MKNK2 GPRK7 MNK2	QLsPPsQsKLAQRRQRAsLssAPVVLVGDHA__________
Q9HBH9	S74	Sugiyama	MKNK2 GPRK7 MNK2	IDIPDAKKRGKKKKRGRAtDsFsGRFEDVYQLQEDVLGEGA
Q9HBH9	T430	Sugiyama	MKNK2 GPRK7 MNK2	DEDLAEEEAAGQGQPVLVRAtsRCLQLsPPsQsKLAQRRQR
Q9HBH9	T72	Sugiyama	MKNK2 GPRK7 MNK2	QPIDIPDAKKRGKKKKRGRAtDsFsGRFEDVYQLQEDVLGE
Q9HCN8	S40	Sugiyama	SDF2L1 UNQ1941/PRO4424	ALLVPGGGAAKTGAELVTCGsVLKLLNTHHRVRLHSHDIKY
Q9NP61	S212	Sugiyama	ARFGAP3 ARFGAP1	EQGPSVEGLNVPTKATLEVssIIKKKPNQAKKGLGAKKGSL
Q9NP61	S437	Sugiyama	ARFGAP3 ARFGAP1	AQKKFGNVKAIssDMyFGRQsQADYETRARLERLsAsssIs
Q9NSB2	S178	Sugiyama	KRT84 KRTHB4	AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NYF8	S319	Sugiyama	BCLAF1 BTF KIAA0164	RsPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKR
Q9NYF8	S320	Sugiyama	BCLAF1 BTF KIAA0164	sPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRF
Q9NZL9	S16	Sugiyama	MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995	_____MVGREKELsIHFVPGsCRLVEEEVNIPNRRVLVtGA
Q9NZL9	S9	Sugiyama	MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995	____________MVGREKELsIHFVPGsCRLVEEEVNIPNR
Q9UHA3	S68	Sugiyama	RSL24D1 C15orf15 RPL24L My024	KVRWTKAFRKAAGKELtVDNsFEFEKRRNEPIKYQRELWNK
Q9UHB6	S617	Sugiyama	LIMA1 EPLIN SREBP3 PP624	FQstsVKsPKtVsPPIRKGWsMsEQSEESVGGRVAERKQVE
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UK32	S389	Sugiyama	RPS6KA6 RSK4	PKDsPGLPAsANAHQLFKGFsFVAtsIAEEYKITPITSANV
Q9UK32	S394	Sugiyama	RPS6KA6 RSK4	GLPAsANAHQLFKGFsFVAtsIAEEYKITPITSANVLPIVQ
Q9ULX3	S390	Sugiyama	NOB1 ART4 NOB1P PSMD8BP1 MSTP158	VsPFVENDISSRSATLQVRDsTLGAGRRRLNPNASRKKFVK
Q9UNH7	S316	Sugiyama	SNX6	LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UPQ0	S201	Sugiyama	LIMCH1 KIAA1102	DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9Y2B0	S63	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2W1	S232	Sugiyama	THRAP3 BCLAF2 TRAP150	QDTKAsEssKPWPDAtyGtGsAsRAsAVsELsPRERsPALK
Q9Y2W1	S237	Sugiyama	THRAP3 BCLAF2 TRAP150	sEssKPWPDAtyGtGsAsRAsAVsELsPRERsPALKsPLQs

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Signal Transduction	R-HSA-162582	1.240722e-08	7.906
Cell Cycle	R-HSA-1640170	1.945707e-08	7.711
Chromatin modifying enzymes	R-HSA-3247509	7.243485e-08	7.140
HSF1-dependent transactivation	R-HSA-3371571	2.973503e-07	6.527
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	4.235528e-07	6.373
Chromatin organization	R-HSA-4839726	5.247021e-07	6.280
Attenuation phase	R-HSA-3371568	1.127462e-06	5.948
Mitotic Prometaphase	R-HSA-68877	8.109782e-06	5.091
Meiotic synapsis	R-HSA-1221632	1.770183e-05	4.752
Cell Cycle, Mitotic	R-HSA-69278	1.575272e-05	4.803
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.692840e-05	4.771
Cellular response to heat stress	R-HSA-3371556	3.707401e-05	4.431
Cellular Senescence	R-HSA-2559583	5.258305e-05	4.279
Axon guidance	R-HSA-422475	5.400496e-05	4.268
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	5.621753e-05	4.250
HDMs demethylate histones	R-HSA-3214842	5.824861e-05	4.235
Nervous system development	R-HSA-9675108	7.094156e-05	4.149
HDACs deacetylate histones	R-HSA-3214815	8.120301e-05	4.090
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	8.091686e-05	4.092
Meiosis	R-HSA-1500620	8.651114e-05	4.063
Apoptotic execution phase	R-HSA-75153	8.768695e-05	4.057
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	9.934775e-05	4.003
NRAGE signals death through JNK	R-HSA-193648	1.005685e-04	3.998
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.400250e-04	3.854
G alpha (12/13) signalling events	R-HSA-416482	1.517117e-04	3.819
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.525398e-04	3.817
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.543233e-04	3.812
HSF1 activation	R-HSA-3371511	1.653657e-04	3.782
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.692374e-04	3.772
Oxidative Stress Induced Senescence	R-HSA-2559580	1.692374e-04	3.772
Transcriptional regulation by RUNX1	R-HSA-8878171	1.786611e-04	3.748
M Phase	R-HSA-68886	1.927000e-04	3.715
Oncogenic MAPK signaling	R-HSA-6802957	2.057364e-04	3.687
Amplification of signal from the kinetochores	R-HSA-141424	2.415644e-04	3.617
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.415644e-04	3.617
Cell Cycle Checkpoints	R-HSA-69620	3.513864e-04	3.454
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.616516e-04	3.442
Semaphorin interactions	R-HSA-373755	3.931762e-04	3.405
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	3.946813e-04	3.404
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.963364e-04	3.402
RMTs methylate histone arginines	R-HSA-3214858	4.578059e-04	3.339
HATs acetylate histones	R-HSA-3214847	5.207349e-04	3.283
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	5.125147e-04	3.290
Regulation of CDH1 Gene Transcription	R-HSA-9764560	5.409962e-04	3.267
Kinesins	R-HSA-983189	5.708301e-04	3.243
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	6.613848e-04	3.180
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	8.750787e-04	3.058
Death Receptor Signaling	R-HSA-73887	8.765491e-04	3.057
Diseases of programmed cell death	R-HSA-9645723	8.468523e-04	3.072
Regulation of TP53 Activity	R-HSA-5633007	8.786934e-04	3.056
Transcriptional Regulation by TP53	R-HSA-3700989	9.358658e-04	3.029
p75 NTR receptor-mediated signalling	R-HSA-193704	1.090411e-03	2.962
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.098724e-03	2.959
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.123791e-03	2.949
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.138476e-03	2.944
Activation of HOX genes during differentiation	R-HSA-5619507	1.138476e-03	2.944
Centrosome maturation	R-HSA-380287	1.185934e-03	2.926
Mitotic Spindle Checkpoint	R-HSA-69618	1.238256e-03	2.907
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.246992e-03	2.904
Reproduction	R-HSA-1474165	1.284742e-03	2.891
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.321675e-03	2.879
ESR-mediated signaling	R-HSA-8939211	1.374228e-03	2.862
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.410143e-03	2.851
Estrogen-dependent gene expression	R-HSA-9018519	1.441192e-03	2.841
AURKA Activation by TPX2	R-HSA-8854518	1.545450e-03	2.811
PKMTs methylate histone lysines	R-HSA-3214841	1.482941e-03	2.829
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.798412e-03	2.745
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.902863e-03	2.721
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.831254e-03	2.737
Neurodegenerative Diseases	R-HSA-8863678	1.831254e-03	2.737
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.090680e-03	2.680
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.220240e-03	2.654
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.220240e-03	2.654
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	2.622069e-03	2.581
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.693891e-03	2.570
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.019672e-03	2.520
Signaling by AXIN mutants	R-HSA-4839735	3.331367e-03	2.477
Signaling by GSK3beta mutants	R-HSA-5339716	3.331367e-03	2.477
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	3.192513e-03	2.496
Activation of RAC1	R-HSA-428540	3.331367e-03	2.477
Post NMDA receptor activation events	R-HSA-438064	3.253565e-03	2.488
Deubiquitination	R-HSA-5688426	3.263253e-03	2.486
EPH-Ephrin signaling	R-HSA-2682334	3.357995e-03	2.474
PRC2 methylates histones and DNA	R-HSA-212300	3.888630e-03	2.410
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	3.828724e-03	2.417
Rap1 signalling	R-HSA-392517	3.970418e-03	2.401
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	4.020910e-03	2.396
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	4.705096e-03	2.327
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	4.705096e-03	2.327
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	4.705096e-03	2.327
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	4.705096e-03	2.327
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	4.705096e-03	2.327
Assembly of the ORC complex at the origin of replication	R-HSA-68616	4.725796e-03	2.326
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	5.140474e-03	2.289
DNA methylation	R-HSA-5334118	5.724779e-03	2.242
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.139664e-03	2.212
Breakdown of the nuclear lamina	R-HSA-352238	6.790937e-03	2.168
Separation of Sister Chromatids	R-HSA-2467813	6.662296e-03	2.176
Sema4D in semaphorin signaling	R-HSA-400685	6.902791e-03	2.161
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	6.999490e-03	2.155
MAPK family signaling cascades	R-HSA-5683057	7.065195e-03	2.151
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	7.479387e-03	2.126
Signaling by Hippo	R-HSA-2028269	7.639835e-03	2.117
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	7.978238e-03	2.098
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	8.247819e-03	2.084
Mitotic Anaphase	R-HSA-68882	8.033339e-03	2.095
Metalloprotease DUBs	R-HSA-5689901	8.496904e-03	2.071
Mitotic Metaphase and Anaphase	R-HSA-2555396	8.597328e-03	2.066
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	8.610599e-03	2.065
Signaling by APC mutants	R-HSA-4839744	9.436831e-03	2.025
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	9.436831e-03	2.025
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	9.436831e-03	2.025
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	9.436831e-03	2.025
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	8.994158e-03	2.046
Protein-protein interactions at synapses	R-HSA-6794362	8.924006e-03	2.049
Ub-specific processing proteases	R-HSA-5689880	8.829341e-03	2.054
G2/M Transition	R-HSA-69275	8.910357e-03	2.050
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.035931e-02	1.985
Packaging Of Telomere Ends	R-HSA-171306	1.035931e-02	1.985
Signaling downstream of RAS mutants	R-HSA-9649948	1.013287e-02	1.994
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.013287e-02	1.994
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.013287e-02	1.994
Ephrin signaling	R-HSA-3928664	9.792512e-03	2.009
Synaptic adhesion-like molecules	R-HSA-8849932	9.792512e-03	2.009
Signaling by WNT in cancer	R-HSA-4791275	1.015276e-02	1.993
Signaling by RAS mutants	R-HSA-6802949	1.013287e-02	1.994
RNA Polymerase I Promoter Opening	R-HSA-73728	1.035931e-02	1.985
Mitotic G2-G2/M phases	R-HSA-453274	1.028234e-02	1.988
Neurexins and neuroligins	R-HSA-6794361	1.081496e-02	1.966
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.096311e-02	1.960
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.108728e-02	1.955
Beta-catenin phosphorylation cascade	R-HSA-196299	1.140013e-02	1.943
Signaling by Nuclear Receptors	R-HSA-9006931	1.147684e-02	1.940
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.149995e-02	1.939
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.151962e-02	1.939
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.286972e-02	1.890
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.238180e-02	1.907
Epigenetic regulation of gene expression	R-HSA-212165	1.208794e-02	1.918
Gene expression (Transcription)	R-HSA-74160	1.241835e-02	1.906
Cellular responses to stress	R-HSA-2262752	1.191965e-02	1.924
Signaling by AMER1 mutants	R-HSA-4839748	1.286972e-02	1.890
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.347275e-02	1.871
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.348802e-02	1.870
Selective autophagy	R-HSA-9663891	1.365163e-02	1.865
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.458923e-02	1.836
FOXO-mediated transcription	R-HSA-9614085	1.477191e-02	1.831
Formation of definitive endoderm	R-HSA-9823730	1.540393e-02	1.812
MITF-M-regulated melanocyte development	R-HSA-9730414	1.562151e-02	1.806
Intracellular signaling by second messengers	R-HSA-9006925	1.587633e-02	1.799
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.683365e-02	1.774
Signaling by LTK	R-HSA-9842663	1.709401e-02	1.767
RAF/MAP kinase cascade	R-HSA-5673001	1.742052e-02	1.759
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.823626e-02	1.739
Nucleosome assembly	R-HSA-774815	1.927163e-02	1.715
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.927163e-02	1.715
Signaling by ROBO receptors	R-HSA-376176	1.803288e-02	1.744
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.966265e-02	1.706
Meiotic recombination	R-HSA-912446	2.000221e-02	1.699
Macroautophagy	R-HSA-1632852	2.015875e-02	1.696
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	2.048215e-02	1.689
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	2.102374e-02	1.677
FLT3 Signaling	R-HSA-9607240	2.102374e-02	1.677
RNA Polymerase II Transcription	R-HSA-73857	2.188666e-02	1.660
Muscle contraction	R-HSA-397014	2.208029e-02	1.656
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	2.218513e-02	1.654
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.303972e-02	1.638
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.303972e-02	1.638
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.462572e-02	1.609
mRNA 3'-end processing	R-HSA-72187	2.263732e-02	1.645
Signaling by RAF1 mutants	R-HSA-9656223	2.411522e-02	1.618
MAP2K and MAPK activation	R-HSA-5674135	2.411522e-02	1.618
Autophagy	R-HSA-9612973	2.482417e-02	1.605
Apoptosis	R-HSA-109581	2.386859e-02	1.622
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.462572e-02	1.609
MAPK1/MAPK3 signaling	R-HSA-5684996	2.494503e-02	1.603
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.578275e-02	1.589
MITF-M-dependent gene expression	R-HSA-9856651	2.581089e-02	1.588
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.585505e-02	1.587
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.635094e-02	1.579
SIRT1 negatively regulates rRNA expression	R-HSA-427359	2.635094e-02	1.579
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.688102e-02	1.571
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.688102e-02	1.571
Diseases of Telomere Maintenance	R-HSA-9673013	2.688102e-02	1.571
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.688102e-02	1.571
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.688102e-02	1.571
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.688102e-02	1.571
TCF dependent signaling in response to WNT	R-HSA-201681	2.727956e-02	1.564
Regulation of NFE2L2 gene expression	R-HSA-9818749	2.828657e-02	1.548
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.864991e-02	1.543
Integrin signaling	R-HSA-354192	2.864991e-02	1.543
MTOR signalling	R-HSA-165159	2.752783e-02	1.560
Neuronal System	R-HSA-112316	3.026447e-02	1.519
Generic Transcription Pathway	R-HSA-212436	3.090976e-02	1.510
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.852683e-02	1.545
Defective pyroptosis	R-HSA-9710421	3.127805e-02	1.505
G-protein mediated events	R-HSA-112040	3.183583e-02	1.497
RNA Polymerase II Transcription Termination	R-HSA-73856	3.207159e-02	1.494
PIP3 activates AKT signaling	R-HSA-1257604	3.321275e-02	1.479
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.419664e-02	1.466
Cellular responses to stimuli	R-HSA-8953897	3.427662e-02	1.465
G2/M DNA damage checkpoint	R-HSA-69473	3.461302e-02	1.461
Specification of the neural plate border	R-HSA-9834899	3.462008e-02	1.461
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.602474e-02	1.443
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.602474e-02	1.443
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.602474e-02	1.443
DARPP-32 events	R-HSA-180024	3.606615e-02	1.443
Regulation of HMOX1 expression and activity	R-HSA-9707587	4.127653e-02	1.384
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.127653e-02	1.384
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	3.915840e-02	1.407
RUNX3 regulates WNT signaling	R-HSA-8951430	3.915840e-02	1.407
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.915840e-02	1.407
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	3.915840e-02	1.407
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.176639e-02	1.379
RAF activation	R-HSA-5673000	3.805642e-02	1.420
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	4.058693e-02	1.392
Aggrephagy	R-HSA-9646399	3.925173e-02	1.406
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	4.058693e-02	1.392
Signal amplification	R-HSA-392518	3.805642e-02	1.420
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.127653e-02	1.384
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.127653e-02	1.384
Opioid Signalling	R-HSA-111885	3.882650e-02	1.411
MECP2 regulates transcription factors	R-HSA-9022707	3.915840e-02	1.407
UCH proteinases	R-HSA-5689603	4.165208e-02	1.380
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	4.326731e-02	1.364
Condensation of Prophase Chromosomes	R-HSA-2299718	4.470559e-02	1.350
Signaling by TGFBR3	R-HSA-9839373	4.470559e-02	1.350
TGFBR3 expression	R-HSA-9839394	4.557033e-02	1.341
Long-term potentiation	R-HSA-9620244	4.557033e-02	1.341
Programmed Cell Death	R-HSA-5357801	4.661919e-02	1.331
Rab regulation of trafficking	R-HSA-9007101	4.814687e-02	1.317
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	4.996424e-02	1.301
Negative regulation of MAPK pathway	R-HSA-5675221	4.996424e-02	1.301
Signaling by WNT	R-HSA-195721	5.207793e-02	1.283
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	5.209948e-02	1.283
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	5.209948e-02	1.283
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	5.209948e-02	1.283
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.401975e-02	1.267
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	5.573842e-02	1.254
MyD88 deficiency (TLR5)	R-HSA-5602680	5.573842e-02	1.254
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	5.573842e-02	1.254
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	5.580655e-02	1.253
Cleavage of the damaged purine	R-HSA-110331	5.584279e-02	1.253
Cleavage of the damaged pyrimidine	R-HSA-110329	5.599632e-02	1.252
Depyrimidination	R-HSA-73928	5.599632e-02	1.252
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.988820e-02	1.223
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.988820e-02	1.223
Formation of axial mesoderm	R-HSA-9796292	6.627420e-02	1.179
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	6.091141e-02	1.215
Chromosome Maintenance	R-HSA-73886	6.281457e-02	1.202
Frs2-mediated activation	R-HSA-170968	6.627420e-02	1.179
Activation of ATR in response to replication stress	R-HSA-176187	6.239592e-02	1.205
Golgi-to-ER retrograde transport	R-HSA-8856688	6.107052e-02	1.214
Cilium Assembly	R-HSA-5617833	5.944062e-02	1.226
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	6.627420e-02	1.179
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	5.784287e-02	1.238
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	6.239592e-02	1.205
Specification of primordial germ cells	R-HSA-9827857	6.256786e-02	1.204
NrCAM interactions	R-HSA-447038	5.988820e-02	1.223
Depurination	R-HSA-73927	6.281126e-02	1.202
Ion homeostasis	R-HSA-5578775	6.654196e-02	1.177
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	6.708923e-02	1.173
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	6.708923e-02	1.173
AKT phosphorylates targets in the nucleus	R-HSA-198693	6.708923e-02	1.173
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	6.708923e-02	1.173
mTORC1-mediated signalling	R-HSA-166208	6.730229e-02	1.172
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	6.730229e-02	1.172
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	6.730229e-02	1.172
Netrin-1 signaling	R-HSA-373752	6.946428e-02	1.158
L1CAM interactions	R-HSA-373760	7.006746e-02	1.154
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	7.031690e-02	1.153
Interleukin-12 signaling	R-HSA-9020591	7.156033e-02	1.145
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	7.210727e-02	1.142
Regulation of CDH1 Expression and Function	R-HSA-9764265	7.210727e-02	1.142
Polo-like kinase mediated events	R-HSA-156711	7.384770e-02	1.132
Chaperone Mediated Autophagy	R-HSA-9613829	7.384770e-02	1.132
Cell junction organization	R-HSA-446728	7.385657e-02	1.132
Late endosomal microautophagy	R-HSA-9615710	7.914272e-02	1.102
cGMP effects	R-HSA-418457	7.994647e-02	1.097
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	7.994647e-02	1.097
Diseases of cellular response to stress	R-HSA-9675132	9.140239e-02	1.039
Diseases of Cellular Senescence	R-HSA-9630747	9.140239e-02	1.039
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	9.140239e-02	1.039
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	9.140239e-02	1.039
Potassium transport channels	R-HSA-1296067	9.140239e-02	1.039
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	8.173510e-02	1.088
Signaling by MAPK mutants	R-HSA-9652817	8.173510e-02	1.088
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	8.406171e-02	1.075
Sema3A PAK dependent Axon repulsion	R-HSA-399954	9.500244e-02	1.022
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.935362e-02	1.049
Nuclear Receptor transcription pathway	R-HSA-383280	8.356128e-02	1.078
Regulation of endogenous retroelements	R-HSA-9842860	8.590705e-02	1.066
Telomere Maintenance	R-HSA-157579	9.612435e-02	1.017
Germ layer formation at gastrulation	R-HSA-9754189	8.620931e-02	1.064
Signal attenuation	R-HSA-74749	8.406171e-02	1.075
MET activates RAP1 and RAC1	R-HSA-8875555	8.406171e-02	1.075
Signaling by FGFR1 in disease	R-HSA-5655302	9.610529e-02	1.017
Signalling to ERKs	R-HSA-187687	8.856374e-02	1.053
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	8.406171e-02	1.075
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	8.173510e-02	1.088
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.242191e-02	1.034
Mitotic Prophase	R-HSA-68875	8.945408e-02	1.048
Transcriptional regulation by RUNX3	R-HSA-8878159	9.612435e-02	1.017
Organelle biogenesis and maintenance	R-HSA-1852241	9.335014e-02	1.030
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	8.058203e-02	1.094
Transcriptional regulation by small RNAs	R-HSA-5578749	8.717270e-02	1.060
RET signaling	R-HSA-8853659	9.853673e-02	1.006
Signaling by ERBB4	R-HSA-1236394	1.013543e-01	0.994
GPER1 signaling	R-HSA-9634597	1.021763e-01	0.991
Co-stimulation by CD28	R-HSA-389356	1.021763e-01	0.991
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.029130e-01	0.988
Interleukin-2 signaling	R-HSA-9020558	1.029130e-01	0.988
Developmental Biology	R-HSA-1266738	1.054144e-01	0.977
DNA Repair	R-HSA-73894	1.058604e-01	0.975
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.061098e-01	0.974
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.061098e-01	0.974
PTK6 promotes HIF1A stabilization	R-HSA-8857538	1.064773e-01	0.973
Heme signaling	R-HSA-9707616	1.110570e-01	0.954
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.113893e-01	0.953
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	1.113893e-01	0.953
Prolonged ERK activation events	R-HSA-169893	1.113893e-01	0.953
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.123820e-01	0.949
Signaling by NTRKs	R-HSA-166520	1.125559e-01	0.949
Drug resistance of KIT mutants	R-HSA-9669937	1.183898e-01	0.927
KIT mutants bind TKIs	R-HSA-9669921	1.183898e-01	0.927
Masitinib-resistant KIT mutants	R-HSA-9669924	1.183898e-01	0.927
Imatinib-resistant KIT mutants	R-HSA-9669917	1.183898e-01	0.927
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.183898e-01	0.927
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.183898e-01	0.927
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.183898e-01	0.927
Evasion of Oncogene Induced Senescence Due to p14ARF Defects	R-HSA-9646303	1.183898e-01	0.927
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.183898e-01	0.927
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.183898e-01	0.927
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.183898e-01	0.927
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	R-HSA-9646304	1.183898e-01	0.927
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.183898e-01	0.927
MET interacts with TNS proteins	R-HSA-8875513	1.318584e-01	0.880
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.318584e-01	0.880
IRAK4 deficiency (TLR5)	R-HSA-5603037	1.318584e-01	0.880
SOS-mediated signalling	R-HSA-112412	1.337286e-01	0.874
Cohesin Loading onto Chromatin	R-HSA-2470946	1.337286e-01	0.874
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.235085e-01	0.908
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	1.235085e-01	0.908
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.140929e-01	0.943
EPHA-mediated growth cone collapse	R-HSA-3928663	1.275708e-01	0.894
Telomere Extension By Telomerase	R-HSA-171319	1.421007e-01	0.847
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.421007e-01	0.847
Resolution of D-Loop Structures	R-HSA-5693537	1.373298e-01	0.862
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.373298e-01	0.862
Striated Muscle Contraction	R-HSA-390522	1.373298e-01	0.862
mRNA Splicing - Major Pathway	R-HSA-72163	1.366219e-01	0.864
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	1.203321e-01	0.920
Signaling by EGFR	R-HSA-177929	1.161737e-01	0.935
TRP channels	R-HSA-3295583	1.138322e-01	0.944
NoRC negatively regulates rRNA expression	R-HSA-427413	1.316739e-01	0.881
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.380634e-01	0.860
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.232068e-01	0.909
Regulation of MECP2 expression and activity	R-HSA-9022692	1.242955e-01	0.906
FGFR1 mutant receptor activation	R-HSA-1839124	1.242955e-01	0.906
DAG and IP3 signaling	R-HSA-1489509	1.380634e-01	0.860
Effects of PIP2 hydrolysis	R-HSA-114508	1.373298e-01	0.862
RNA Polymerase I Transcription	R-HSA-73864	1.337128e-01	0.874
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	1.203321e-01	0.920
Cardiac conduction	R-HSA-5576891	1.246133e-01	0.904
Cell-Cell communication	R-HSA-1500931	1.339111e-01	0.873
Regulation of PTEN localization	R-HSA-8948747	1.337286e-01	0.874
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.242955e-01	0.906
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.168717e-01	0.932
EPHB-mediated forward signaling	R-HSA-3928662	1.267822e-01	0.897
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.275708e-01	0.894
Formation of RNA Pol II elongation complex	R-HSA-112382	1.425714e-01	0.846
RNA Polymerase I Promoter Escape	R-HSA-73772	1.425714e-01	0.846
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.227695e-01	0.652
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	2.227695e-01	0.652
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9630791	2.227695e-01	0.652
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.227695e-01	0.652
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9632697	2.227695e-01	0.652
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.227695e-01	0.652
HCN channels	R-HSA-1296061	1.754731e-01	0.756
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.754731e-01	0.756
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.754731e-01	0.756
PI and PC transport between ER and Golgi membranes	R-HSA-1483196	3.147964e-01	0.502
Interactions of Tat with host cellular proteins	R-HSA-176034	3.147964e-01	0.502
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	3.147964e-01	0.502
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	3.147964e-01	0.502
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	3.147964e-01	0.502
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	R-HSA-73930	3.147964e-01	0.502
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	3.147964e-01	0.502
Mitochondrial transcription initiation	R-HSA-163282	3.147964e-01	0.502
Intestinal infectious diseases	R-HSA-8942233	3.147964e-01	0.502
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.147964e-01	0.502
Signaling by kinase domain mutants of KIT	R-HSA-9669933	3.147964e-01	0.502
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.147964e-01	0.502
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.147964e-01	0.502
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	3.147964e-01	0.502
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	3.147964e-01	0.502
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.147964e-01	0.502
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.147964e-01	0.502
Signaling by TCF7L2 mutants	R-HSA-5339700	3.147964e-01	0.502
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	3.147964e-01	0.502
MPS IIID - Sanfilippo syndrome D	R-HSA-2206305	3.147964e-01	0.502
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	2.209324e-01	0.656
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.209324e-01	0.656
IRS activation	R-HSA-74713	2.209324e-01	0.656
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.209324e-01	0.656
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.209324e-01	0.656
ROBO receptors bind AKAP5	R-HSA-9010642	1.630824e-01	0.788
Type I hemidesmosome assembly	R-HSA-446107	1.630824e-01	0.788
FGFR1b ligand binding and activation	R-HSA-190370	1.630824e-01	0.788
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.456902e-01	0.837
SHC-related events triggered by IGF1R	R-HSA-2428933	1.456902e-01	0.837
Lipophagy	R-HSA-9613354	1.941297e-01	0.712
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.671889e-01	0.573
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	2.671889e-01	0.573
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	2.671889e-01	0.573
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.671889e-01	0.573
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.671889e-01	0.573
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.671889e-01	0.573
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	2.671889e-01	0.573
Signaling by RNF43 mutants	R-HSA-5340588	2.671889e-01	0.573
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	3.959317e-01	0.402
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	3.959317e-01	0.402
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	3.959317e-01	0.402
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	3.959317e-01	0.402
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.959317e-01	0.402
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	3.959317e-01	0.402
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	3.959317e-01	0.402
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	3.959317e-01	0.402
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	3.959317e-01	0.402
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	3.959317e-01	0.402
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	3.959317e-01	0.402
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	3.959317e-01	0.402
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	3.959317e-01	0.402
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.959317e-01	0.402
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.959317e-01	0.402
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	3.959317e-01	0.402
TWIK related potassium channel (TREK)	R-HSA-1299503	3.959317e-01	0.402
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.959317e-01	0.402
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	3.959317e-01	0.402
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	1.692832e-01	0.771
PI3K/AKT activation	R-HSA-198203	2.264732e-01	0.645
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	2.264732e-01	0.645
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	2.264732e-01	0.645
Regulation of KIT signaling	R-HSA-1433559	1.941018e-01	0.712
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.941018e-01	0.712
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.941018e-01	0.712
CREB phosphorylation	R-HSA-199920	3.134171e-01	0.504
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	3.134171e-01	0.504
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.134171e-01	0.504
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.134171e-01	0.504
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.459430e-01	0.836
ChREBP activates metabolic gene expression	R-HSA-163765	2.597369e-01	0.585
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.597369e-01	0.585
Activated NTRK3 signals through RAS	R-HSA-9034864	2.597369e-01	0.585
DCC mediated attractive signaling	R-HSA-418885	2.199547e-01	0.658
Erythropoietin activates RAS	R-HSA-9027284	2.199547e-01	0.658
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.199547e-01	0.658
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.199547e-01	0.658
Adenylate cyclase inhibitory pathway	R-HSA-170670	2.199547e-01	0.658
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.199547e-01	0.658
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.886677e-01	0.724
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.573854e-01	0.803
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.104296e-01	0.677
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	2.104296e-01	0.677
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.104296e-01	0.677
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.104296e-01	0.677
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.104296e-01	0.677
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.104296e-01	0.677
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.466494e-01	0.608
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	2.935723e-01	0.532
Activated NTRK2 signals through RAS	R-HSA-9026519	2.935723e-01	0.532
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.935723e-01	0.532
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	3.589756e-01	0.445
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	3.589756e-01	0.445
Netrin mediated repulsion signals	R-HSA-418886	3.589756e-01	0.445
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.589756e-01	0.445
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	3.589756e-01	0.445
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	3.589756e-01	0.445
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.589756e-01	0.445
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	4.674639e-01	0.330
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	4.674639e-01	0.330
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	4.674639e-01	0.330
Axonal growth stimulation	R-HSA-209563	4.674639e-01	0.330
Defective GCLC causes HAGGSD	R-HSA-5578999	4.674639e-01	0.330
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.674639e-01	0.330
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.674639e-01	0.330
Invadopodia formation	R-HSA-8941237	4.674639e-01	0.330
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.733831e-01	0.761
Tight junction interactions	R-HSA-420029	2.002017e-01	0.699
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	2.002017e-01	0.699
SHC-mediated cascade:FGFR3	R-HSA-5654704	2.329471e-01	0.633
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.739963e-01	0.562
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	2.197459e-01	0.658
SHC-mediated cascade:FGFR4	R-HSA-5654719	2.561036e-01	0.592
Voltage gated Potassium channels	R-HSA-1296072	1.957373e-01	0.708
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.398931e-01	0.620
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.398931e-01	0.620
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.018116e-01	0.520
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.033753e-01	0.394
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	4.033753e-01	0.394
Signaling by MRAS-complex mutants	R-HSA-9660537	4.033753e-01	0.394
Activation of RAS in B cells	R-HSA-1169092	4.033753e-01	0.394
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.033753e-01	0.394
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.538223e-01	0.813
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.251710e-01	0.647
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	2.251710e-01	0.647
Notch-HLH transcription pathway	R-HSA-350054	2.797815e-01	0.553
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.605635e-01	0.584
HIV elongation arrest and recovery	R-HSA-167287	2.605635e-01	0.584
Pausing and recovery of HIV elongation	R-HSA-167290	2.605635e-01	0.584
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	3.617230e-01	0.442
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	3.617230e-01	0.442
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.435205e-01	0.613
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.282236e-01	0.642
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.299200e-01	0.482
Signaling by Erythropoietin	R-HSA-9006335	2.816764e-01	0.550
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.816764e-01	0.550
HIV Transcription Elongation	R-HSA-167169	2.451475e-01	0.611
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.451475e-01	0.611
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.451475e-01	0.611
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.451475e-01	0.611
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	1.805925e-01	0.743
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.919552e-01	0.717
Signaling by ERBB2 in Cancer	R-HSA-1227990	3.031506e-01	0.518
Activation of the pre-replicative complex	R-HSA-68962	3.031506e-01	0.518
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.282394e-01	0.484
Thromboxane signalling through TP receptor	R-HSA-428930	3.282394e-01	0.484
SHC-mediated cascade:FGFR1	R-HSA-5654688	3.282394e-01	0.484
Signaling by FGFR2 IIIa TM	R-HSA-8851708	3.581563e-01	0.446
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.581563e-01	0.446
NRIF signals cell death from the nucleus	R-HSA-205043	3.955045e-01	0.403
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	3.955045e-01	0.403
Inactivation of CDC42 and RAC1	R-HSA-428543	4.462520e-01	0.350
CASP8 activity is inhibited	R-HSA-5218900	4.462520e-01	0.350
TNFR1-mediated ceramide production	R-HSA-5626978	5.305292e-01	0.275
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	5.305292e-01	0.275
AKT-mediated inactivation of FOXO1A	R-HSA-211163	5.305292e-01	0.275
MPS VI - Maroteaux-Lamy syndrome	R-HSA-2206285	5.305292e-01	0.275
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.305292e-01	0.275
Signaling by LRP5 mutants	R-HSA-5339717	5.305292e-01	0.275
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	1.920711e-01	0.717
ATP-dependent chromatin remodelers	R-HSA-9932444	3.527960e-01	0.452
SWI/SNF chromatin remodelers	R-HSA-9932451	3.527960e-01	0.452
Co-inhibition by CTLA4	R-HSA-389513	3.863670e-01	0.413
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.863670e-01	0.413
Spry regulation of FGF signaling	R-HSA-1295596	4.287905e-01	0.368
SHC1 events in EGFR signaling	R-HSA-180336	4.287905e-01	0.368
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	4.287905e-01	0.368
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	3.774292e-01	0.423
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.689439e-01	0.433
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.873439e-01	0.312
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.609318e-01	0.443
mRNA Splicing	R-HSA-72172	1.583189e-01	0.800
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	3.231073e-01	0.491
SHC-mediated cascade:FGFR2	R-HSA-5654699	4.020399e-01	0.396
Interaction between L1 and Ankyrins	R-HSA-445095	4.020399e-01	0.396
FRS-mediated FGFR3 signaling	R-HSA-5654706	4.421619e-01	0.354
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.682593e-01	0.774
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.265347e-01	0.370
Formation of the Early Elongation Complex	R-HSA-113418	4.265347e-01	0.370
Negative regulation of FGFR2 signaling	R-HSA-5654727	4.131874e-01	0.384
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.508273e-01	0.346
FRS-mediated FGFR4 signaling	R-HSA-5654712	4.695040e-01	0.328
Processing of Intronless Pre-mRNAs	R-HSA-77595	4.931680e-01	0.307
GRB2 events in ERBB2 signaling	R-HSA-1963640	4.931680e-01	0.307
Phase 2 - plateau phase	R-HSA-5576893	4.931680e-01	0.307
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	5.264725e-01	0.279
FGFR2b ligand binding and activation	R-HSA-190377	5.264725e-01	0.279
HCMV Early Events	R-HSA-9609690	3.118682e-01	0.506
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	4.570831e-01	0.340
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.967814e-01	0.401
Interleukin receptor SHC signaling	R-HSA-912526	4.963369e-01	0.304
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	4.963369e-01	0.304
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.966598e-01	0.402
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.966598e-01	0.402
PI3K events in ERBB2 signaling	R-HSA-1963642	5.239793e-01	0.281
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.239793e-01	0.281
Trafficking of AMPA receptors	R-HSA-399719	4.984954e-01	0.302
Metabolism of non-coding RNA	R-HSA-194441	4.690461e-01	0.329
snRNP Assembly	R-HSA-191859	4.690461e-01	0.329
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	5.225727e-01	0.282
Deadenylation of mRNA	R-HSA-429947	5.225727e-01	0.282
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	5.225727e-01	0.282
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	5.635267e-01	0.249
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	5.635267e-01	0.249
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.635267e-01	0.249
ERKs are inactivated	R-HSA-202670	5.635267e-01	0.249
Transcription of the HIV genome	R-HSA-167172	4.882233e-01	0.311
RNA Polymerase III Transcription Termination	R-HSA-73980	5.537298e-01	0.257
mRNA Splicing - Minor Pathway	R-HSA-72165	5.209131e-01	0.283
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.481361e-01	0.261
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.444963e-01	0.264
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.470302e-01	0.262
IKK complex recruitment mediated by RIP1	R-HSA-937041	5.823424e-01	0.235
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	5.623931e-01	0.250
Formation of a pool of free 40S subunits	R-HSA-72689	5.759388e-01	0.240
Signaling by FGFR2	R-HSA-5654738	4.312802e-01	0.365
PKR-mediated signaling	R-HSA-9833482	1.518489e-01	0.819
RNA Polymerase III Transcription	R-HSA-74158	4.570831e-01	0.340
Downstream signaling of activated FGFR1	R-HSA-5654687	4.352110e-01	0.361
Downstream signaling of activated FGFR3	R-HSA-5654708	2.816764e-01	0.550
Downstream signaling of activated FGFR4	R-HSA-5654716	3.031506e-01	0.518
Downstream signaling of activated FGFR2	R-HSA-5654696	4.352110e-01	0.361
EGFR downregulation	R-HSA-182971	3.249056e-01	0.488
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.800429e-01	0.553
Constitutive Signaling by EGFRvIII	R-HSA-5637810	5.239793e-01	0.281
Signaling by EGFRvIII in Cancer	R-HSA-5637812	5.239793e-01	0.281
DAP12 signaling	R-HSA-2424491	1.733831e-01	0.761
KEAP1-NFE2L2 pathway	R-HSA-9755511	4.679437e-01	0.330
Adipogenesis	R-HSA-9843745	3.114960e-01	0.507
Negative regulation of FGFR1 signaling	R-HSA-5654726	3.689439e-01	0.433
G-protein beta:gamma signalling	R-HSA-397795	5.444963e-01	0.264
Signaling by FGFR3	R-HSA-5654741	2.297346e-01	0.639
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.677762e-01	0.775
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	2.451475e-01	0.611
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	2.451475e-01	0.611
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	3.910759e-01	0.408
Signaling by FGFR4	R-HSA-5654743	1.994272e-01	0.700
Signaling by SCF-KIT	R-HSA-1433557	3.163309e-01	0.500
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.038646e-01	0.517
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.787448e-01	0.320
Signaling by ERBB2	R-HSA-1227986	1.567561e-01	0.805
Mitophagy	R-HSA-5205647	4.131874e-01	0.384
VxPx cargo-targeting to cilium	R-HSA-5620916	3.863670e-01	0.413
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.299234e-01	0.638
Extension of Telomeres	R-HSA-180786	4.690461e-01	0.329
Transcriptional regulation of testis differentiation	R-HSA-9690406	2.739963e-01	0.562
G0 and Early G1	R-HSA-1538133	2.073279e-01	0.683
Processing of DNA double-strand break ends	R-HSA-5693607	1.613891e-01	0.792
Signaling by FGFR1	R-HSA-5654736	2.911253e-01	0.536
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.121076e-01	0.506
DNA Double-Strand Break Repair	R-HSA-5693532	2.543783e-01	0.595
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.919552e-01	0.717
Fanconi Anemia Pathway	R-HSA-6783310	5.014813e-01	0.300
PKA-mediated phosphorylation of CREB	R-HSA-111931	4.144115e-01	0.383
Nuclear import of Rev protein	R-HSA-180746	4.131874e-01	0.384
Myogenesis	R-HSA-525793	5.729639e-01	0.242
PI-3K cascade:FGFR3	R-HSA-5654710	5.823424e-01	0.235
Homology Directed Repair	R-HSA-5693538	2.336754e-01	0.631
DNA Double Strand Break Response	R-HSA-5693606	3.483590e-01	0.458
DNA Replication Pre-Initiation	R-HSA-69002	3.594170e-01	0.444
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.911253e-01	0.536
Insulin receptor signalling cascade	R-HSA-74751	5.541220e-01	0.256
Apoptosis induced DNA fragmentation	R-HSA-140342	2.264732e-01	0.645
Regulation of the apoptosome activity	R-HSA-9627069	2.264732e-01	0.645
Cytochrome c-mediated apoptotic response	R-HSA-111461	2.935723e-01	0.532
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.588883e-01	0.799
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.518489e-01	0.819
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.783587e-01	0.749
IGF1R signaling cascade	R-HSA-2428924	2.036159e-01	0.691
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.404894e-01	0.619
GAB1 signalosome	R-HSA-180292	5.537298e-01	0.257
Formation of lateral plate mesoderm	R-HSA-9758920	2.671889e-01	0.573
Formation of apoptosome	R-HSA-111458	2.264732e-01	0.645
Elevation of cytosolic Ca2+ levels	R-HSA-139853	1.478650e-01	0.830
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.589756e-01	0.445
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.574594e-01	0.803
Diseases of mitotic cell cycle	R-HSA-9675126	2.073279e-01	0.683
Lysosphingolipid and LPA receptors	R-HSA-419408	4.287905e-01	0.368
Signalling to RAS	R-HSA-167044	4.144115e-01	0.383
Regulation of CDH11 function	R-HSA-9762292	4.873439e-01	0.312
Induction of Cell-Cell Fusion	R-HSA-9733458	4.613964e-01	0.336
Peptide chain elongation	R-HSA-156902	5.639722e-01	0.249
Extra-nuclear estrogen signaling	R-HSA-9009391	1.801529e-01	0.744
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.523856e-01	0.258
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.510212e-01	0.821
Apoptotic factor-mediated response	R-HSA-111471	3.299200e-01	0.482
Assembly of the pre-replicative complex	R-HSA-68867	2.338893e-01	0.631
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	1.510212e-01	0.821
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	3.276623e-01	0.485
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.462520e-01	0.350
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	3.468624e-01	0.460
G1 Phase	R-HSA-69236	4.817997e-01	0.317
Cyclin D associated events in G1	R-HSA-69231	4.817997e-01	0.317
GPVI-mediated activation cascade	R-HSA-114604	4.570831e-01	0.340
TNF signaling	R-HSA-75893	2.911253e-01	0.536
Role of second messengers in netrin-1 signaling	R-HSA-418890	1.456902e-01	0.837
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	1.941297e-01	0.712
Regulation by c-FLIP	R-HSA-3371378	4.033753e-01	0.394
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.033753e-01	0.394
p75NTR regulates axonogenesis	R-HSA-193697	4.462520e-01	0.350
Regulation of gap junction activity	R-HSA-191650	5.305292e-01	0.275
Telomere C-strand synthesis initiation	R-HSA-174430	4.287905e-01	0.368
MET promotes cell motility	R-HSA-8875878	3.407922e-01	0.468
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	4.144115e-01	0.383
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.207077e-01	0.494
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	4.931680e-01	0.307
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	3.796510e-01	0.421
IRS-related events triggered by IGF1R	R-HSA-2428928	5.036167e-01	0.298
PKA activation	R-HSA-163615	5.537298e-01	0.257
Interactions of Rev with host cellular proteins	R-HSA-177243	5.419414e-01	0.266
S Phase	R-HSA-69242	3.521594e-01	0.453
Ca2+ pathway	R-HSA-4086398	3.266586e-01	0.486
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.162087e-01	0.665
Nuclear RNA decay	R-HSA-9930044	5.444963e-01	0.264
Regulation of TNFR1 signaling	R-HSA-5357905	5.209131e-01	0.283
RIPK1-mediated regulated necrosis	R-HSA-5213460	5.001411e-01	0.301
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.197459e-01	0.658
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	4.284430e-01	0.368
Repression of WNT target genes	R-HSA-4641265	1.456902e-01	0.837
Receptor Mediated Mitophagy	R-HSA-8934903	2.264732e-01	0.645
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	2.816764e-01	0.550
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	4.020399e-01	0.396
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.987939e-01	0.399
Acetylcholine regulates insulin secretion	R-HSA-399997	4.931680e-01	0.307
Platelet activation, signaling and aggregation	R-HSA-76002	1.813676e-01	0.741
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.455981e-01	0.837
Calmodulin induced events	R-HSA-111933	1.802586e-01	0.744
Oncogene Induced Senescence	R-HSA-2559585	2.815043e-01	0.551
HCMV Infection	R-HSA-9609646	5.247885e-01	0.280
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.634081e-01	0.579
Adrenoceptors	R-HSA-390696	1.630824e-01	0.788
Calcineurin activates NFAT	R-HSA-2025928	1.941297e-01	0.712
Transcription from mitochondrial promoters	R-HSA-75944	3.959317e-01	0.402
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.692832e-01	0.771
Abacavir transmembrane transport	R-HSA-2161517	3.134171e-01	0.504
Ca2+ activated K+ channels	R-HSA-1296052	3.589756e-01	0.445
CaM pathway	R-HSA-111997	1.802586e-01	0.744
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.033753e-01	0.394
Dimerization of procaspase-8	R-HSA-69416	4.033753e-01	0.394
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.251710e-01	0.647
FGFR1c ligand binding and activation	R-HSA-190373	3.617230e-01	0.442
Defects in biotin (Btn) metabolism	R-HSA-3323169	4.462520e-01	0.350
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.873439e-01	0.312
Formation of the posterior neural plate	R-HSA-9832991	5.264725e-01	0.279
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	4.748382e-01	0.323
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.442632e-01	0.352
Sensing of DNA Double Strand Breaks	R-HSA-5693548	5.635267e-01	0.249
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.481361e-01	0.261
Eukaryotic Translation Elongation	R-HSA-156842	5.208519e-01	0.283
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	5.470302e-01	0.262
IRS-mediated signalling	R-HSA-112399	5.735708e-01	0.241
Mitotic G1 phase and G1/S transition	R-HSA-453279	4.130749e-01	0.384
Signaling by FGFR in disease	R-HSA-1226099	3.413546e-01	0.467
PLC beta mediated events	R-HSA-112043	1.679133e-01	0.775
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.624478e-01	0.789
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.508273e-01	0.346
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.920406e-01	0.535
Signaling by VEGF	R-HSA-194138	2.403809e-01	0.619
Platelet calcium homeostasis	R-HSA-418360	2.816764e-01	0.550
Integration of energy metabolism	R-HSA-163685	4.648472e-01	0.333
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.375015e-01	0.270
NGF-stimulated transcription	R-HSA-9031628	5.588825e-01	0.253
Regulation of necroptotic cell death	R-HSA-5675482	3.689439e-01	0.433
Transcriptional Regulation by VENTX	R-HSA-8853884	2.624664e-01	0.581
Cell-extracellular matrix interactions	R-HSA-446353	2.199547e-01	0.658
CRMPs in Sema3A signaling	R-HSA-399956	3.955045e-01	0.403
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.305292e-01	0.275
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	5.635267e-01	0.249
Transmission across Chemical Synapses	R-HSA-112315	3.005594e-01	0.522
Pre-NOTCH Transcription and Translation	R-HSA-1912408	4.925482e-01	0.308
Hedgehog 'off' state	R-HSA-5610787	5.344460e-01	0.272
Cardiogenesis	R-HSA-9733709	2.251710e-01	0.647
Ca-dependent events	R-HSA-111996	2.981050e-01	0.526
Generation of second messenger molecules	R-HSA-202433	3.811626e-01	0.419
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	5.729639e-01	0.242
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.479886e-01	0.830
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	3.617230e-01	0.442
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	3.533603e-01	0.452
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.481361e-01	0.261
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	5.509409e-01	0.259
G1/S DNA Damage Checkpoints	R-HSA-69615	4.054742e-01	0.392
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.444963e-01	0.264
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	1.941018e-01	0.712
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	1.653414e-01	0.782
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.014286e-01	0.396
Ovarian tumor domain proteases	R-HSA-5689896	4.787448e-01	0.320
FGFR1 ligand binding and activation	R-HSA-190242	5.537298e-01	0.257
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.667318e-01	0.247
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.012088e-01	0.696
mRNA Editing	R-HSA-75072	4.462520e-01	0.350
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.349571e-01	0.475
Mitochondrial biogenesis	R-HSA-1592230	4.843311e-01	0.315
Signaling by TGFB family members	R-HSA-9006936	2.506984e-01	0.601
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.001214e-01	0.523
Potassium Channels	R-HSA-1296071	2.003648e-01	0.698
Membrane Trafficking	R-HSA-199991	2.095999e-01	0.679
G2/M Checkpoints	R-HSA-69481	1.926429e-01	0.715
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	5.225727e-01	0.282
Cell-cell junction organization	R-HSA-421270	1.764826e-01	0.753
Adherens junctions interactions	R-HSA-418990	2.535057e-01	0.596
Regulation of PTEN gene transcription	R-HSA-8943724	1.567561e-01	0.805
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	1.913581e-01	0.718
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.723329e-01	0.764
Signaling by NOTCH1	R-HSA-1980143	4.898250e-01	0.310
Co-inhibition by PD-1	R-HSA-389948	5.713085e-01	0.243
Signaling by ALK in cancer	R-HSA-9700206	3.349571e-01	0.475
Formation of editosomes by ADAR proteins	R-HSA-77042	2.227695e-01	0.652
Inhibition of PKR	R-HSA-169131	2.227695e-01	0.652
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.147964e-01	0.502
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	1.630824e-01	0.788
ARMS-mediated activation	R-HSA-170984	1.941297e-01	0.712
CDC6 association with the ORC:origin complex	R-HSA-68689	2.671889e-01	0.573
mRNA Editing: A to I Conversion	R-HSA-75064	3.959317e-01	0.402
C6 deamination of adenosine	R-HSA-75102	3.959317e-01	0.402
Ionotropic activity of kainate receptors	R-HSA-451306	2.597369e-01	0.585
Phase 4 - resting membrane potential	R-HSA-5576886	2.466494e-01	0.608
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	3.589756e-01	0.445
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	1.510212e-01	0.821
Mitochondrial calcium ion transport	R-HSA-8949215	2.561036e-01	0.592
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	3.018116e-01	0.520
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	3.617230e-01	0.442
Unwinding of DNA	R-HSA-176974	4.462520e-01	0.350
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	4.462520e-01	0.350
Transmission across Electrical Synapses	R-HSA-112307	5.305292e-01	0.275
Alanine metabolism	R-HSA-8964540	5.305292e-01	0.275
Electric Transmission Across Gap Junctions	R-HSA-112303	5.305292e-01	0.275
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	5.305292e-01	0.275
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.305292e-01	0.275
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.451268e-01	0.611
EGFR Transactivation by Gastrin	R-HSA-2179392	4.873439e-01	0.312
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	4.873439e-01	0.312
Nuclear signaling by ERBB4	R-HSA-1251985	3.811626e-01	0.419
Sodium/Calcium exchangers	R-HSA-425561	5.635267e-01	0.249
Signaling by activated point mutants of FGFR1	R-HSA-1839122	5.635267e-01	0.249
Cytoprotection by HMOX1	R-HSA-9707564	4.763555e-01	0.322
PKA activation in glucagon signalling	R-HSA-164378	5.537298e-01	0.257
Regulation of insulin secretion	R-HSA-422356	5.073971e-01	0.295
Intraflagellar transport	R-HSA-5620924	5.588825e-01	0.253
E2F mediated regulation of DNA replication	R-HSA-113510	5.823424e-01	0.235
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.658031e-01	0.247
Regulation of T cell activation by CD28 family	R-HSA-388841	3.130112e-01	0.504
DAP12 interactions	R-HSA-2172127	4.817997e-01	0.317
Intrinsic Pathway for Apoptosis	R-HSA-109606	2.911253e-01	0.536
Nuclear Envelope Breakdown	R-HSA-2980766	3.070158e-01	0.513
Pexophagy	R-HSA-9664873	4.873439e-01	0.312
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.421619e-01	0.354
FLT3 signaling in disease	R-HSA-9682385	4.570831e-01	0.340
Amyloid fiber formation	R-HSA-977225	3.347033e-01	0.475
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	3.888509e-01	0.410
Cargo trafficking to the periciliary membrane	R-HSA-5620920	4.112045e-01	0.386
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	5.823424e-01	0.235
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	3.068580e-01	0.513
Interleukin-2 family signaling	R-HSA-451927	5.419414e-01	0.266
Signaling by PTK6	R-HSA-8848021	2.873644e-01	0.542
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	2.873644e-01	0.542
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.199547e-01	0.658
Recycling pathway of L1	R-HSA-437239	1.621327e-01	0.790
Activated NTRK2 signals through FYN	R-HSA-9032500	4.033753e-01	0.394
Regulation of CDH11 gene transcription	R-HSA-9762293	4.462520e-01	0.350
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	4.462520e-01	0.350
TBC/RABGAPs	R-HSA-8854214	3.163309e-01	0.500
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	4.931680e-01	0.307
Signaling by NTRK3 (TRKC)	R-HSA-9034015	2.561036e-01	0.592
Formation of the nephric duct	R-HSA-9830364	3.527960e-01	0.452
Gap junction trafficking and regulation	R-HSA-157858	5.773552e-01	0.239
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.558117e-01	0.592
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.692832e-01	0.771
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.589756e-01	0.445
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	3.617230e-01	0.442
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	4.462520e-01	0.350
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	4.462520e-01	0.350
Protein hydroxylation	R-HSA-9629569	3.863670e-01	0.413
LGI-ADAM interactions	R-HSA-5682910	5.264725e-01	0.279
Glycolysis	R-HSA-70171	2.422819e-01	0.616
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	3.533603e-01	0.452
NOD1/2 Signaling Pathway	R-HSA-168638	4.131874e-01	0.384
The NLRP3 inflammasome	R-HSA-844456	5.823424e-01	0.235
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.462520e-01	0.350
Smooth Muscle Contraction	R-HSA-445355	2.449734e-01	0.611
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	3.774292e-01	0.423
Stimuli-sensing channels	R-HSA-2672351	3.471415e-01	0.459
Base Excision Repair	R-HSA-73884	3.691735e-01	0.433
Hemostasis	R-HSA-109582	3.720718e-01	0.429
Regulation of TP53 Degradation	R-HSA-6804757	1.802586e-01	0.744
CD209 (DC-SIGN) signaling	R-HSA-5621575	3.282394e-01	0.484
Interleukin-15 signaling	R-HSA-8983432	3.276623e-01	0.485
Uptake and function of anthrax toxins	R-HSA-5210891	5.239793e-01	0.281
DSCAM interactions	R-HSA-376172	3.959317e-01	0.402
Tandem pore domain potassium channels	R-HSA-1296346	2.264732e-01	0.645
Synthesis of PI	R-HSA-1483226	2.597369e-01	0.585
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.674639e-01	0.330
Maturation of nucleoprotein	R-HSA-9683610	3.617230e-01	0.442
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.299200e-01	0.482
Transport of connexons to the plasma membrane	R-HSA-190872	3.299200e-01	0.482
Regulation of gene expression in beta cells	R-HSA-210745	2.816764e-01	0.550
Sensory perception of sour taste	R-HSA-9729555	5.305292e-01	0.275
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	4.144115e-01	0.383
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	4.873439e-01	0.312
Negative regulation of FLT3	R-HSA-9706369	4.613964e-01	0.336
Disorders of Developmental Biology	R-HSA-9675151	4.931680e-01	0.307
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.418521e-01	0.355
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	5.225727e-01	0.282
Activation of BH3-only proteins	R-HSA-114452	3.031506e-01	0.518
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.282236e-01	0.642
Transcriptional Regulation by MECP2	R-HSA-8986944	3.829492e-01	0.417
MHC class II antigen presentation	R-HSA-2132295	2.122164e-01	0.673
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.541220e-01	0.256
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.206441e-01	0.283
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	5.667318e-01	0.247
Interleukin-37 signaling	R-HSA-9008059	1.733831e-01	0.761
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.561036e-01	0.592
Signaling by ALK	R-HSA-201556	2.282236e-01	0.642
G1/S-Specific Transcription	R-HSA-69205	3.010189e-01	0.521
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.689439e-01	0.433
Tie2 Signaling	R-HSA-210993	5.537298e-01	0.257
PI Metabolism	R-HSA-1483255	5.610190e-01	0.251
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	4.020399e-01	0.396
Glucose metabolism	R-HSA-70326	3.883511e-01	0.411
Transcriptional Regulation by E2F6	R-HSA-8953750	2.282236e-01	0.642
Cytokine Signaling in Immune system	R-HSA-1280215	3.409099e-01	0.467
Formation of the anterior neural plate	R-HSA-9823739	4.287905e-01	0.368
Diseases of DNA repair	R-HSA-9675135	2.454909e-01	0.610
Phase 3 - rapid repolarisation	R-HSA-5576890	3.589756e-01	0.445
Cation-coupled Chloride cotransporters	R-HSA-426117	3.589756e-01	0.445
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	4.674639e-01	0.330
RUNX3 regulates p14-ARF	R-HSA-8951936	3.276623e-01	0.485
FLT3 signaling through SRC family kinases	R-HSA-9706374	5.305292e-01	0.275
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	5.305292e-01	0.275
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	4.613964e-01	0.336
Interleukin-7 signaling	R-HSA-1266695	2.002017e-01	0.699
Maturation of nucleoprotein	R-HSA-9694631	5.823424e-01	0.235
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.671889e-01	0.573
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	3.959317e-01	0.402
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.199547e-01	0.658
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	5.264725e-01	0.279
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	5.635267e-01	0.249
Signaling by Interleukins	R-HSA-449147	4.435971e-01	0.353
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.677643e-01	0.775
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.299200e-01	0.482
Gene Silencing by RNA	R-HSA-211000	3.349571e-01	0.475
CD28 dependent Vav1 pathway	R-HSA-389359	3.617230e-01	0.442
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.655107e-01	0.781
Platelet sensitization by LDL	R-HSA-432142	5.537298e-01	0.257
STING mediated induction of host immune responses	R-HSA-1834941	3.581563e-01	0.446
Signaling by Leptin	R-HSA-2586552	4.873439e-01	0.312
Interleukin-12 family signaling	R-HSA-447115	1.619824e-01	0.791
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	5.537298e-01	0.257
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.861292e-01	0.232
Activation of AMPA receptors	R-HSA-399710	5.861292e-01	0.232
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	5.861292e-01	0.232
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	5.861292e-01	0.232
NOSIP mediated eNOS trafficking	R-HSA-203754	5.861292e-01	0.232
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.861292e-01	0.232
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	5.861292e-01	0.232
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.861292e-01	0.232
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.861292e-01	0.232
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.861292e-01	0.232
Suppression of autophagy	R-HSA-9636569	5.861292e-01	0.232
Muscarinic acetylcholine receptors	R-HSA-390648	5.861292e-01	0.232
PTK6 Down-Regulation	R-HSA-8849472	5.861292e-01	0.232
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	5.861292e-01	0.232
Zinc efflux and compartmentalization by the SLC30 family	R-HSA-435368	5.861292e-01	0.232
Gap junction assembly	R-HSA-190861	5.883968e-01	0.230
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.883968e-01	0.230
CLEC7A (Dectin-1) signaling	R-HSA-5607764	5.893120e-01	0.230
G1/S Transition	R-HSA-69206	5.931917e-01	0.227
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	5.945940e-01	0.226
PI3K Cascade	R-HSA-109704	5.954487e-01	0.225
Cristae formation	R-HSA-8949613	5.970043e-01	0.224
Signaling by FGFR3 in disease	R-HSA-5655332	5.970043e-01	0.224
ISG15 antiviral mechanism	R-HSA-1169408	5.983682e-01	0.223
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	5.984490e-01	0.223
Polymerase switching	R-HSA-69091	5.984490e-01	0.223
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	5.984490e-01	0.223
Leading Strand Synthesis	R-HSA-69109	5.984490e-01	0.223
GRB2 events in EGFR signaling	R-HSA-179812	5.984490e-01	0.223
p75NTR recruits signalling complexes	R-HSA-209543	5.984490e-01	0.223
MET activates RAS signaling	R-HSA-8851805	5.984490e-01	0.223
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.984490e-01	0.223
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.984490e-01	0.223
Estrogen biosynthesis	R-HSA-193144	5.984490e-01	0.223
OAS antiviral response	R-HSA-8983711	5.984490e-01	0.223
Pervasive developmental disorders	R-HSA-9005895	5.984490e-01	0.223
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.984490e-01	0.223
Disorders of Nervous System Development	R-HSA-9697154	5.984490e-01	0.223
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.015457e-01	0.221
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	6.015457e-01	0.221
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	6.055917e-01	0.218
Cellular response to chemical stress	R-HSA-9711123	6.082606e-01	0.216
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.091203e-01	0.215
PI-3K cascade:FGFR4	R-HSA-5654720	6.097608e-01	0.215
Post-chaperonin tubulin folding pathway	R-HSA-389977	6.097608e-01	0.215
Signaling by NODAL	R-HSA-1181150	6.097608e-01	0.215
Signal transduction by L1	R-HSA-445144	6.097608e-01	0.215
Creatine metabolism	R-HSA-71288	6.097608e-01	0.215
rRNA processing in the nucleus and cytosol	R-HSA-8868773	6.112293e-01	0.214
Nucleotide Excision Repair	R-HSA-5696398	6.123464e-01	0.213
Signaling by FGFR	R-HSA-190236	6.154944e-01	0.211
Regulated Necrosis	R-HSA-5218859	6.179463e-01	0.209
HCMV Late Events	R-HSA-9610379	6.180484e-01	0.209
IRE1alpha activates chaperones	R-HSA-381070	6.190463e-01	0.208
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	6.202159e-01	0.207
FRS-mediated FGFR2 signaling	R-HSA-5654700	6.202159e-01	0.207
Phase 0 - rapid depolarisation	R-HSA-5576892	6.202159e-01	0.207
Activation of kainate receptors upon glutamate binding	R-HSA-451326	6.202159e-01	0.207
MAPK6/MAPK4 signaling	R-HSA-5687128	6.230886e-01	0.205
GABA receptor activation	R-HSA-977443	6.235864e-01	0.205
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	6.235864e-01	0.205
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	6.235864e-01	0.205
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	6.235864e-01	0.205
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	6.235864e-01	0.205
Signaling by NOTCH1 in Cancer	R-HSA-2644603	6.235864e-01	0.205
Platelet homeostasis	R-HSA-418346	6.247368e-01	0.204
Lysosome Vesicle Biogenesis	R-HSA-432720	6.298742e-01	0.201
Triglyceride catabolism	R-HSA-163560	6.298742e-01	0.201
Potential therapeutics for SARS	R-HSA-9679191	6.304412e-01	0.200
Acetylcholine binding and downstream events	R-HSA-181431	6.312246e-01	0.200
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	6.312246e-01	0.200
FGFR2c ligand binding and activation	R-HSA-190375	6.312246e-01	0.200
FGFR4 ligand binding and activation	R-HSA-190322	6.312246e-01	0.200
Processing of SMDT1	R-HSA-8949664	6.312246e-01	0.200
PI5P Regulates TP53 Acetylation	R-HSA-6811555	6.312246e-01	0.200
Signaling by activated point mutants of FGFR3	R-HSA-1839130	6.312246e-01	0.200
Reversible hydration of carbon dioxide	R-HSA-1475029	6.312246e-01	0.200
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	6.312246e-01	0.200
FGFR3 mutant receptor activation	R-HSA-2033514	6.312246e-01	0.200
TRAIL signaling	R-HSA-75158	6.351472e-01	0.197
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.351472e-01	0.197
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.351472e-01	0.197
PDE3B signalling	R-HSA-165160	6.351472e-01	0.197
PKB-mediated events	R-HSA-109703	6.351472e-01	0.197
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.351472e-01	0.197
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.351472e-01	0.197
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	6.351472e-01	0.197
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.351472e-01	0.197
Formation of the Editosome	R-HSA-75094	6.351472e-01	0.197
Phosphorylation of Emi1	R-HSA-176417	6.351472e-01	0.197
Noncanonical activation of NOTCH3	R-HSA-9017802	6.351472e-01	0.197
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.351472e-01	0.197
Negative feedback regulation of MAPK pathway	R-HSA-5674499	6.351472e-01	0.197
Signalling to p38 via RIT and RIN	R-HSA-187706	6.351472e-01	0.197
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	6.351472e-01	0.197
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.351472e-01	0.197
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.351472e-01	0.197
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	6.359471e-01	0.197
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	6.359471e-01	0.197
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.359471e-01	0.197
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	6.359471e-01	0.197
Gap junction trafficking	R-HSA-190828	6.388437e-01	0.195
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	6.425674e-01	0.192
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.425674e-01	0.192
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	6.452596e-01	0.190
Cyclin E associated events during G1/S transition	R-HSA-69202	6.480134e-01	0.188
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.608796e-01	0.180
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.618721e-01	0.179
Removal of the Flap Intermediate	R-HSA-69166	6.618721e-01	0.179
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	6.618721e-01	0.179
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.618721e-01	0.179
FGFR3c ligand binding and activation	R-HSA-190372	6.618721e-01	0.179
Signaling by FGFR4 in disease	R-HSA-5655291	6.618721e-01	0.179
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	6.618721e-01	0.179
HDL assembly	R-HSA-8963896	6.618721e-01	0.179
Signal regulatory protein family interactions	R-HSA-391160	6.618721e-01	0.179
Zinc transporters	R-HSA-435354	6.618721e-01	0.179
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	6.640361e-01	0.178
RNA Polymerase III Transcription Initiation	R-HSA-76046	6.640361e-01	0.178
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	6.640361e-01	0.178
Downregulation of ERBB2 signaling	R-HSA-8863795	6.640361e-01	0.178
Cap-dependent Translation Initiation	R-HSA-72737	6.678169e-01	0.175
Eukaryotic Translation Initiation	R-HSA-72613	6.678169e-01	0.175
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	6.687066e-01	0.175
Signaling by MET	R-HSA-6806834	6.695866e-01	0.174
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	6.739808e-01	0.171
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	6.767019e-01	0.170
Erythropoietin activates STAT5	R-HSA-9027283	6.783622e-01	0.169
STAT5 Activation	R-HSA-9645135	6.783622e-01	0.169
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.783622e-01	0.169
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	6.783622e-01	0.169
NADPH regeneration	R-HSA-389542	6.783622e-01	0.169
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.783622e-01	0.169
Nef and signal transduction	R-HSA-164944	6.783622e-01	0.169
Lipid particle organization	R-HSA-8964572	6.783622e-01	0.169
Neurofascin interactions	R-HSA-447043	6.783622e-01	0.169
Eukaryotic Translation Termination	R-HSA-72764	6.827031e-01	0.166
G alpha (s) signalling events	R-HSA-418555	6.830519e-01	0.166
Signaling by KIT in disease	R-HSA-9669938	6.845506e-01	0.165
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	6.845506e-01	0.165
FGFR2 alternative splicing	R-HSA-6803529	6.845506e-01	0.165
PI-3K cascade:FGFR1	R-HSA-5654689	6.845506e-01	0.165
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.845506e-01	0.165
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	6.845506e-01	0.165
RAF-independent MAPK1/3 activation	R-HSA-112409	6.845506e-01	0.165
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	6.845506e-01	0.165
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	6.846078e-01	0.165
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	6.846078e-01	0.165
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	6.846078e-01	0.165
Downstream signal transduction	R-HSA-186763	6.846078e-01	0.165
NS1 Mediated Effects on Host Pathways	R-HSA-168276	6.870865e-01	0.163
Response of endothelial cells to shear stress	R-HSA-9860931	6.888352e-01	0.162
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	6.904358e-01	0.161
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	6.904358e-01	0.161
Processive synthesis on the lagging strand	R-HSA-69183	6.904358e-01	0.161
p75NTR signals via NF-kB	R-HSA-193639	6.904358e-01	0.161
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	6.904358e-01	0.161
FGFR3 ligand binding and activation	R-HSA-190239	6.904358e-01	0.161
p38MAPK events	R-HSA-171007	6.904358e-01	0.161
Biotin transport and metabolism	R-HSA-196780	6.904358e-01	0.161
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.904358e-01	0.161
Activation of BAD and translocation to mitochondria	R-HSA-111447	6.904358e-01	0.161
Other semaphorin interactions	R-HSA-416700	6.904358e-01	0.161
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	6.904358e-01	0.161
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.904358e-01	0.161
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	6.907022e-01	0.161
Ion channel transport	R-HSA-983712	6.947148e-01	0.158
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	6.948844e-01	0.158
HIV Life Cycle	R-HSA-162587	6.988724e-01	0.156
Gastrulation	R-HSA-9758941	7.026440e-01	0.153
DNA strand elongation	R-HSA-69190	7.042754e-01	0.152
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	7.068463e-01	0.151
Carnitine shuttle	R-HSA-200425	7.069642e-01	0.151
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.069642e-01	0.151
Late Phase of HIV Life Cycle	R-HSA-162599	7.161638e-01	0.145
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.164608e-01	0.145
TRIF-mediated programmed cell death	R-HSA-2562578	7.164608e-01	0.145
FGFR3b ligand binding and activation	R-HSA-190371	7.164608e-01	0.145
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.164608e-01	0.145
mRNA Editing: C to U Conversion	R-HSA-72200	7.164608e-01	0.145
PTK6 Expression	R-HSA-8849473	7.164608e-01	0.145
Activated NTRK2 signals through CDK5	R-HSA-9032845	7.164608e-01	0.145
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	7.164608e-01	0.145
Synthesis of PIPs in the nucleus	R-HSA-8847453	7.164608e-01	0.145
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	7.164608e-01	0.145
CHL1 interactions	R-HSA-447041	7.164608e-01	0.145
Displacement of DNA glycosylase by APEX1	R-HSA-110357	7.164608e-01	0.145
Phosphorylation of the APC/C	R-HSA-176412	7.169792e-01	0.144
Defective GALNT3 causes HFTC	R-HSA-5083625	7.169792e-01	0.144
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	7.169792e-01	0.144
Defective GALNT12 causes CRCS1	R-HSA-5083636	7.169792e-01	0.144
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	7.169792e-01	0.144
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	7.169792e-01	0.144
Killing mechanisms	R-HSA-9664420	7.169792e-01	0.144
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	7.169792e-01	0.144
Regulation of BACH1 activity	R-HSA-9708530	7.169792e-01	0.144
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	7.169792e-01	0.144
Differentiation of T cells	R-HSA-9945266	7.169792e-01	0.144
Activation of SMO	R-HSA-5635838	7.169792e-01	0.144
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	7.169792e-01	0.144
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.169792e-01	0.144
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.169868e-01	0.144
Nuclear events mediated by NFE2L2	R-HSA-9759194	7.209926e-01	0.142
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.224074e-01	0.141
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.224074e-01	0.141
IPs transport between nucleus and cytosol	R-HSA-1855170	7.230385e-01	0.141
TNFs bind their physiological receptors	R-HSA-5669034	7.281349e-01	0.138
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.281349e-01	0.138
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	7.300322e-01	0.137
Metabolism of RNA	R-HSA-8953854	7.324143e-01	0.135
Signaling by FGFR2 in disease	R-HSA-5655253	7.373832e-01	0.132
Regulation of beta-cell development	R-HSA-186712	7.381495e-01	0.132
DNA Replication	R-HSA-69306	7.388052e-01	0.131
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	7.397701e-01	0.131
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	7.409021e-01	0.130
Miscellaneous transport and binding events	R-HSA-5223345	7.409021e-01	0.130
SHC1 events in ERBB4 signaling	R-HSA-1250347	7.415802e-01	0.130
TRAF3-dependent IRF activation pathway	R-HSA-918233	7.415802e-01	0.130
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	7.415802e-01	0.130
Passive transport by Aquaporins	R-HSA-432047	7.415802e-01	0.130
tRNA modification in the mitochondrion	R-HSA-6787450	7.415802e-01	0.130
Synthesis of PG	R-HSA-1483148	7.415802e-01	0.130
FCERI mediated Ca+2 mobilization	R-HSA-2871809	7.466944e-01	0.127
PI-3K cascade:FGFR2	R-HSA-5654695	7.480855e-01	0.126
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.480855e-01	0.126
Acyl chain remodelling of PS	R-HSA-1482801	7.480855e-01	0.126
Signaling by Hedgehog	R-HSA-5358351	7.483794e-01	0.126
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.500486e-01	0.125
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	7.500486e-01	0.125
Regulation of NPAS4 mRNA translation	R-HSA-9768778	7.500486e-01	0.125
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.500486e-01	0.125
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.500486e-01	0.125
Co-stimulation by ICOS	R-HSA-9927354	7.500486e-01	0.125
Fructose biosynthesis	R-HSA-5652227	7.500486e-01	0.125
Formation of annular gap junctions	R-HSA-196025	7.500486e-01	0.125
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	7.500486e-01	0.125
TGFBR3 PTM regulation	R-HSA-9839383	7.500486e-01	0.125
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	7.500486e-01	0.125
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	7.500486e-01	0.125
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.500486e-01	0.125
Alpha-defensins	R-HSA-1462054	7.500486e-01	0.125
Downregulation of ERBB4 signaling	R-HSA-1253288	7.500486e-01	0.125
Selenocysteine synthesis	R-HSA-2408557	7.502015e-01	0.125
Activation of GABAB receptors	R-HSA-991365	7.535355e-01	0.123
GABA B receptor activation	R-HSA-977444	7.535355e-01	0.123
RNA Polymerase I Transcription Initiation	R-HSA-73762	7.535355e-01	0.123
Developmental Cell Lineages	R-HSA-9734767	7.545365e-01	0.122
XBP1(S) activates chaperone genes	R-HSA-381038	7.557619e-01	0.122
PTEN Regulation	R-HSA-6807070	7.571964e-01	0.121
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	7.578767e-01	0.120
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	7.643263e-01	0.117
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	7.643263e-01	0.117
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	7.643263e-01	0.117
Regulation of FZD by ubiquitination	R-HSA-4641263	7.643263e-01	0.117
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	7.643263e-01	0.117
Regulation of NPAS4 gene expression	R-HSA-9768759	7.643263e-01	0.117
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	7.643263e-01	0.117
MAP kinase activation	R-HSA-450294	7.645005e-01	0.117
Sensory processing of sound	R-HSA-9659379	7.653536e-01	0.116
Signaling by EGFR in Cancer	R-HSA-1643713	7.668458e-01	0.115
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	7.668458e-01	0.115
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.668458e-01	0.115
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	7.668458e-01	0.115
Viral mRNA Translation	R-HSA-192823	7.704054e-01	0.113
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	7.739769e-01	0.111
PERK regulates gene expression	R-HSA-381042	7.739769e-01	0.111
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	7.782232e-01	0.109
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	7.785150e-01	0.109
WNT mediated activation of DVL	R-HSA-201688	7.796592e-01	0.108
ALK mutants bind TKIs	R-HSA-9700645	7.796592e-01	0.108
Gap junction degradation	R-HSA-190873	7.796592e-01	0.108
MASTL Facilitates Mitotic Progression	R-HSA-2465910	7.796592e-01	0.108
Interleukin-1 processing	R-HSA-448706	7.796592e-01	0.108
Regulation of signaling by NODAL	R-HSA-1433617	7.796592e-01	0.108
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.796592e-01	0.108
GP1b-IX-V activation signalling	R-HSA-430116	7.796592e-01	0.108
Regulated proteolysis of p75NTR	R-HSA-193692	7.796592e-01	0.108
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	7.796592e-01	0.108
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.796592e-01	0.108
Cellular response to starvation	R-HSA-9711097	7.799245e-01	0.108
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	7.799245e-01	0.108
Transcriptional regulation by RUNX2	R-HSA-8878166	7.838336e-01	0.106
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.844509e-01	0.105
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.844509e-01	0.105
Insulin processing	R-HSA-264876	7.844509e-01	0.105
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	7.853118e-01	0.105
Activated point mutants of FGFR2	R-HSA-2033519	7.853118e-01	0.105
Mismatch Repair	R-HSA-5358508	7.853118e-01	0.105
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	7.853118e-01	0.105
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	7.853118e-01	0.105
Vitamin D (calciferol) metabolism	R-HSA-196791	7.853118e-01	0.105
Nephron development	R-HSA-9831926	7.853118e-01	0.105
FGFR2 mutant receptor activation	R-HSA-1839126	7.892210e-01	0.103
RUNX2 regulates bone development	R-HSA-8941326	7.892210e-01	0.103
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.908660e-01	0.102
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.960249e-01	0.099
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.960249e-01	0.099
Cellular responses to mechanical stimuli	R-HSA-9855142	7.996005e-01	0.097
Ion transport by P-type ATPases	R-HSA-936837	8.003197e-01	0.097
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.005473e-01	0.097
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.009408e-01	0.096
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.009408e-01	0.096
Inflammasomes	R-HSA-622312	8.009408e-01	0.096
Pyroptosis	R-HSA-5620971	8.009408e-01	0.096
G alpha (z) signalling events	R-HSA-418597	8.035660e-01	0.095
Vpr-mediated nuclear import of PICs	R-HSA-180910	8.036304e-01	0.095
Beta-catenin independent WNT signaling	R-HSA-3858494	8.040234e-01	0.095
Regulation of signaling by CBL	R-HSA-912631	8.046345e-01	0.094
2-LTR circle formation	R-HSA-164843	8.057636e-01	0.094
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	8.057636e-01	0.094
DNA replication initiation	R-HSA-68952	8.057636e-01	0.094
Folding of actin by CCT/TriC	R-HSA-390450	8.057636e-01	0.094
Binding and entry of HIV virion	R-HSA-173107	8.057636e-01	0.094
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.057636e-01	0.094
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	8.057636e-01	0.094
Formation of intermediate mesoderm	R-HSA-9761174	8.057636e-01	0.094
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	8.057636e-01	0.094
Maturation of spike protein	R-HSA-9683686	8.057636e-01	0.094
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.057636e-01	0.094
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	8.069273e-01	0.093
MyD88 cascade initiated on plasma membrane	R-HSA-975871	8.069273e-01	0.093
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	8.069273e-01	0.093
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.088394e-01	0.092
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	8.158439e-01	0.088
mRNA Capping	R-HSA-72086	8.163584e-01	0.088
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.163584e-01	0.088
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.163584e-01	0.088
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.172292e-01	0.088
C-type lectin receptors (CLRs)	R-HSA-5621481	8.181568e-01	0.087
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	8.223937e-01	0.085
Pregnenolone biosynthesis	R-HSA-196108	8.223937e-01	0.085
Signaling by Insulin receptor	R-HSA-74752	8.250428e-01	0.084
Unfolded Protein Response (UPR)	R-HSA-381119	8.262312e-01	0.083
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	8.287766e-01	0.082
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.287766e-01	0.082
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.287766e-01	0.082
Bicarbonate transporters	R-HSA-425381	8.287766e-01	0.082
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	8.287766e-01	0.082
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.287766e-01	0.082
Transport of RCbl within the body	R-HSA-9758890	8.287766e-01	0.082
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.287766e-01	0.082
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.287766e-01	0.082
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.287766e-01	0.082
PECAM1 interactions	R-HSA-210990	8.287766e-01	0.082
Prostanoid ligand receptors	R-HSA-391908	8.287766e-01	0.082
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.300434e-01	0.081
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.307490e-01	0.081
Kidney development	R-HSA-9830369	8.318288e-01	0.080
Metal ion SLC transporters	R-HSA-425410	8.325366e-01	0.080
FGFR2 ligand binding and activation	R-HSA-190241	8.386886e-01	0.076
MyD88 deficiency (TLR2/4)	R-HSA-5602498	8.386886e-01	0.076
Lagging Strand Synthesis	R-HSA-69186	8.386886e-01	0.076
ERK/MAPK targets	R-HSA-198753	8.386886e-01	0.076
Zygotic genome activation (ZGA)	R-HSA-9819196	8.386886e-01	0.076
Early Phase of HIV Life Cycle	R-HSA-162594	8.386886e-01	0.076
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	8.386886e-01	0.076
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.421008e-01	0.075
Glycogen metabolism	R-HSA-8982491	8.421008e-01	0.075
Interactions of Vpr with host cellular proteins	R-HSA-176033	8.421008e-01	0.075
SARS-CoV-1 Infection	R-HSA-9678108	8.433302e-01	0.074
Budding and maturation of HIV virion	R-HSA-162588	8.441597e-01	0.074
Evasion by RSV of host interferon responses	R-HSA-9833109	8.441597e-01	0.074
HIV Infection	R-HSA-162906	8.456503e-01	0.073
Triglyceride metabolism	R-HSA-8979227	8.465463e-01	0.072
Condensation of Prometaphase Chromosomes	R-HSA-2514853	8.490643e-01	0.071
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.490643e-01	0.071
NF-kB is activated and signals survival	R-HSA-209560	8.490643e-01	0.071
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	8.490643e-01	0.071
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.490643e-01	0.071
Reduction of cytosolic Ca++ levels	R-HSA-418359	8.490643e-01	0.071
Integration of provirus	R-HSA-162592	8.490643e-01	0.071
Resolution of Abasic Sites (AP sites)	R-HSA-73933	8.534301e-01	0.069
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	8.534301e-01	0.069
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	8.536168e-01	0.069
Signaling by PDGFR in disease	R-HSA-9671555	8.536168e-01	0.069
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	8.536168e-01	0.069
Regulation of RAS by GAPs	R-HSA-5658442	8.537798e-01	0.069
Interferon Signaling	R-HSA-913531	8.541522e-01	0.068
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	8.554969e-01	0.068
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.591347e-01	0.066
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	8.592685e-01	0.066
Interleukin-17 signaling	R-HSA-448424	8.592685e-01	0.066
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.640611e-01	0.063
HIV Transcription Initiation	R-HSA-167161	8.640611e-01	0.063
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.640611e-01	0.063
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.640611e-01	0.063
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.640611e-01	0.063
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.640611e-01	0.063
Translation of Structural Proteins	R-HSA-9683701	8.640611e-01	0.063
COPI-mediated anterograde transport	R-HSA-6807878	8.645731e-01	0.063
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.649805e-01	0.063
Vesicle-mediated transport	R-HSA-5653656	8.652693e-01	0.063
Influenza Infection	R-HSA-168255	8.658078e-01	0.063
Signaling by NOTCH	R-HSA-157118	8.666675e-01	0.062
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.669492e-01	0.062
IRAK1 recruits IKK complex	R-HSA-937039	8.669492e-01	0.062
RUNX3 regulates NOTCH signaling	R-HSA-8941856	8.669492e-01	0.062
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.669492e-01	0.062
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.669492e-01	0.062
VLDLR internalisation and degradation	R-HSA-8866427	8.669492e-01	0.062
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	8.669492e-01	0.062
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.669492e-01	0.062
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.669492e-01	0.062
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	8.672734e-01	0.062
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	8.672734e-01	0.062
Fructose metabolism	R-HSA-5652084	8.672734e-01	0.062
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	8.672734e-01	0.062
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	8.672734e-01	0.062
Hedgehog 'on' state	R-HSA-5632684	8.675620e-01	0.062
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.682331e-01	0.061
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	8.693674e-01	0.061
Orc1 removal from chromatin	R-HSA-68949	8.727287e-01	0.059
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	8.727287e-01	0.059
Uptake and actions of bacterial toxins	R-HSA-5339562	8.727287e-01	0.059
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.734860e-01	0.059
tRNA processing in the nucleus	R-HSA-6784531	8.734860e-01	0.059
Neurotransmitter release cycle	R-HSA-112310	8.744184e-01	0.058
Neutrophil degranulation	R-HSA-6798695	8.747596e-01	0.058
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.754492e-01	0.058
SARS-CoV-1-host interactions	R-HSA-9692914	8.758924e-01	0.058
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.759597e-01	0.058
Glucagon signaling in metabolic regulation	R-HSA-163359	8.789919e-01	0.056
Heme degradation	R-HSA-189483	8.789919e-01	0.056
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.797501e-01	0.056
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.797501e-01	0.056
Termination of O-glycan biosynthesis	R-HSA-977068	8.797501e-01	0.056
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	8.797501e-01	0.056
Free fatty acids regulate insulin secretion	R-HSA-400451	8.797501e-01	0.056
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	8.797501e-01	0.056
ABC transporters in lipid homeostasis	R-HSA-1369062	8.797501e-01	0.056
Syndecan interactions	R-HSA-3000170	8.797501e-01	0.056
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	8.797501e-01	0.056
Growth hormone receptor signaling	R-HSA-982772	8.797501e-01	0.056
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	8.827157e-01	0.054
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	8.827157e-01	0.054
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.827157e-01	0.054
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.827157e-01	0.054
Chylomicron remodeling	R-HSA-8963901	8.827157e-01	0.054
Mtb iron assimilation by chelation	R-HSA-1222449	8.827157e-01	0.054
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.827157e-01	0.054
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.827157e-01	0.054
Switching of origins to a post-replicative state	R-HSA-69052	8.829428e-01	0.054
RNA Polymerase II Promoter Escape	R-HSA-73776	8.833494e-01	0.054
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	8.868138e-01	0.052
Circadian clock	R-HSA-9909396	8.886312e-01	0.051
Translation initiation complex formation	R-HSA-72649	8.895531e-01	0.051
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.895531e-01	0.051
TRAF6 mediated NF-kB activation	R-HSA-933542	8.911345e-01	0.050
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	8.911345e-01	0.050
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	8.911345e-01	0.050
Mitochondrial RNA degradation	R-HSA-9836573	8.911345e-01	0.050
Plasma lipoprotein assembly	R-HSA-8963898	8.911345e-01	0.050
Amine ligand-binding receptors	R-HSA-375280	8.920677e-01	0.050
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.940303e-01	0.049
The activation of arylsulfatases	R-HSA-1663150	8.966148e-01	0.047
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.966148e-01	0.047
Biosynthesis of protectins	R-HSA-9018681	8.966148e-01	0.047
Retrograde neurotrophin signalling	R-HSA-177504	8.966148e-01	0.047
Physiological factors	R-HSA-5578768	8.966148e-01	0.047
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	8.966148e-01	0.047
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.966148e-01	0.047
Ciprofloxacin ADME	R-HSA-9793528	8.966148e-01	0.047
P2Y receptors	R-HSA-417957	8.966148e-01	0.047
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.966148e-01	0.047
Protein ubiquitination	R-HSA-8852135	8.968015e-01	0.047
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	8.981904e-01	0.047
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	8.994057e-01	0.046
MyD88-independent TLR4 cascade	R-HSA-166166	8.994057e-01	0.046
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.002091e-01	0.046
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.002091e-01	0.046
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.002091e-01	0.046
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.044265e-01	0.044
Ribosomal scanning and start codon recognition	R-HSA-72702	9.044265e-01	0.044
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.044265e-01	0.044
Platelet degranulation	R-HSA-114608	9.052859e-01	0.043
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.067218e-01	0.043
Glycosphingolipid transport	R-HSA-9845576	9.067218e-01	0.043
rRNA processing	R-HSA-72312	9.067256e-01	0.043
Clathrin-mediated endocytosis	R-HSA-8856828	9.068733e-01	0.042
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.078035e-01	0.042
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.078035e-01	0.042
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.078035e-01	0.042
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	9.088674e-01	0.041
G beta:gamma signalling through BTK	R-HSA-8964315	9.088674e-01	0.041
RNA Polymerase III Chain Elongation	R-HSA-73780	9.088674e-01	0.041
Translesion synthesis by REV1	R-HSA-110312	9.088674e-01	0.041
Signaling by Activin	R-HSA-1502540	9.088674e-01	0.041
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	9.088674e-01	0.041
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	9.088674e-01	0.041
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	9.088674e-01	0.041
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	9.088674e-01	0.041
Protein methylation	R-HSA-8876725	9.088674e-01	0.041
DNA Damage Reversal	R-HSA-73942	9.088674e-01	0.041
FCERI mediated MAPK activation	R-HSA-2871796	9.097043e-01	0.041
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	9.098317e-01	0.041
Adaptive Immune System	R-HSA-1280218	9.106283e-01	0.041
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	9.109569e-01	0.041
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	9.109569e-01	0.041
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.109569e-01	0.041
Abacavir ADME	R-HSA-2161522	9.109569e-01	0.041
SLC-mediated transport of organic cations	R-HSA-549127	9.146002e-01	0.039
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.148801e-01	0.039
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.148801e-01	0.039
Dual incision in TC-NER	R-HSA-6782135	9.175218e-01	0.037
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	9.175218e-01	0.037
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.175218e-01	0.037
PPARA activates gene expression	R-HSA-1989781	9.181637e-01	0.037
RNA Polymerase I Transcription Termination	R-HSA-73863	9.195484e-01	0.036
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.195484e-01	0.036
Translesion synthesis by POLI	R-HSA-5656121	9.196685e-01	0.036
WNT5A-dependent internalization of FZD4	R-HSA-5099900	9.196685e-01	0.036
Attachment and Entry	R-HSA-9678110	9.196685e-01	0.036
Activation of the phototransduction cascade	R-HSA-2485179	9.196685e-01	0.036
Class I peroxisomal membrane protein import	R-HSA-9603798	9.196685e-01	0.036
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	9.196685e-01	0.036
Fructose catabolism	R-HSA-70350	9.196685e-01	0.036
Synthesis of wybutosine at G37 of tRNA(Phe)	R-HSA-6782861	9.196685e-01	0.036
Atorvastatin ADME	R-HSA-9754706	9.196685e-01	0.036
Parasitic Infection Pathways	R-HSA-9824443	9.206135e-01	0.036
Leishmania infection	R-HSA-9658195	9.206135e-01	0.036
Ribosome-associated quality control	R-HSA-9948299	9.210464e-01	0.036
GPCR downstream signalling	R-HSA-388396	9.217919e-01	0.035
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.256661e-01	0.034
DNA Damage Bypass	R-HSA-73893	9.275936e-01	0.033
Degradation of CDH1	R-HSA-9766229	9.275936e-01	0.033
Host Interactions of HIV factors	R-HSA-162909	9.290606e-01	0.032
G beta:gamma signalling through CDC42	R-HSA-8964616	9.291900e-01	0.032
Translesion synthesis by POLK	R-HSA-5655862	9.291900e-01	0.032
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.291900e-01	0.032
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	9.291900e-01	0.032
Vitamin B6 activation to pyridoxal phosphate	R-HSA-964975	9.291900e-01	0.032
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	9.291900e-01	0.032
Galactose catabolism	R-HSA-70370	9.291900e-01	0.032
Coenzyme A biosynthesis	R-HSA-196783	9.291900e-01	0.032
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.291900e-01	0.032
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.322931e-01	0.030
Viral Messenger RNA Synthesis	R-HSA-168325	9.341976e-01	0.030
Aquaporin-mediated transport	R-HSA-445717	9.341976e-01	0.030
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.342265e-01	0.030
Termination of translesion DNA synthesis	R-HSA-5656169	9.344417e-01	0.029
Glucagon-type ligand receptors	R-HSA-420092	9.344417e-01	0.029
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	9.346526e-01	0.029
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.347312e-01	0.029
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.347312e-01	0.029
Diseases of Immune System	R-HSA-5260271	9.347312e-01	0.029
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.363435e-01	0.029
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	9.375835e-01	0.028
Glycogen storage diseases	R-HSA-3229121	9.375835e-01	0.028
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	9.375835e-01	0.028
Sulfide oxidation to sulfate	R-HSA-1614517	9.375835e-01	0.028
Catecholamine biosynthesis	R-HSA-209905	9.375835e-01	0.028
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.375835e-01	0.028
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.375835e-01	0.028
MyD88 dependent cascade initiated on endosome	R-HSA-975155	9.384294e-01	0.028
The phototransduction cascade	R-HSA-2514856	9.385684e-01	0.028
Mitochondrial protein import	R-HSA-1268020	9.390453e-01	0.027
NCAM signaling for neurite out-growth	R-HSA-375165	9.390453e-01	0.027
Signaling by PDGF	R-HSA-186797	9.390453e-01	0.027
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.404024e-01	0.027
Maturation of spike protein	R-HSA-9694548	9.404024e-01	0.027
Interleukin-1 family signaling	R-HSA-446652	9.404389e-01	0.027
Mucopolysaccharidoses	R-HSA-2206281	9.408697e-01	0.026
TCR signaling	R-HSA-202403	9.420150e-01	0.026
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.449824e-01	0.025
G beta:gamma signalling through PLC beta	R-HSA-418217	9.449824e-01	0.025
Presynaptic function of Kainate receptors	R-HSA-500657	9.449824e-01	0.025
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.449824e-01	0.025
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.449824e-01	0.025
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.456141e-01	0.024
Intra-Golgi traffic	R-HSA-6811438	9.456141e-01	0.024
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	9.457382e-01	0.024
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	9.457382e-01	0.024
G alpha (q) signalling events	R-HSA-416476	9.465469e-01	0.024
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.466955e-01	0.024
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.466955e-01	0.024
Molecules associated with elastic fibres	R-HSA-2129379	9.466955e-01	0.024
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.466955e-01	0.024
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	9.480081e-01	0.023
Golgi Associated Vesicle Biogenesis	R-HSA-432722	9.480081e-01	0.023
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.488003e-01	0.023
Cytosolic tRNA aminoacylation	R-HSA-379716	9.503992e-01	0.022
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.503992e-01	0.022
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	9.515047e-01	0.022
Pyrimidine biosynthesis	R-HSA-500753	9.515047e-01	0.022
Other interleukin signaling	R-HSA-449836	9.515047e-01	0.022
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.515047e-01	0.022
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	9.516998e-01	0.022
Cellular response to hypoxia	R-HSA-1234174	9.517187e-01	0.021
Inwardly rectifying K+ channels	R-HSA-1296065	9.519715e-01	0.021
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	9.545763e-01	0.020
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	9.545763e-01	0.020
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.547892e-01	0.020
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.553783e-01	0.020
Translation of Structural Proteins	R-HSA-9694635	9.558396e-01	0.020
Signaling by NOTCH3	R-HSA-9012852	9.561002e-01	0.019
Defective B3GALTL causes PpS	R-HSA-5083635	9.567461e-01	0.019
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.572541e-01	0.019
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.572541e-01	0.019
Glycogen synthesis	R-HSA-3322077	9.572541e-01	0.019
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.572541e-01	0.019
Keratan sulfate degradation	R-HSA-2022857	9.572541e-01	0.019
Negative regulation of MET activity	R-HSA-6807004	9.572541e-01	0.019
Nephrin family interactions	R-HSA-373753	9.572541e-01	0.019
Eicosanoid ligand-binding receptors	R-HSA-391903	9.572541e-01	0.019
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.588134e-01	0.018
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	9.599281e-01	0.018
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.599281e-01	0.018
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	9.610640e-01	0.017
Acyl chain remodelling of PC	R-HSA-1482788	9.610640e-01	0.017
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.610640e-01	0.017
Glutamate and glutamine metabolism	R-HSA-8964539	9.610640e-01	0.017
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.619906e-01	0.017
G-protein activation	R-HSA-202040	9.623222e-01	0.017
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	9.623222e-01	0.017
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.623222e-01	0.017
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.623222e-01	0.017
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.623222e-01	0.017
Basigin interactions	R-HSA-210991	9.623222e-01	0.017
Synthesis of DNA	R-HSA-69239	9.629433e-01	0.016
Regulation of CDH1 Function	R-HSA-9764561	9.630151e-01	0.016
Dectin-2 family	R-HSA-5621480	9.630151e-01	0.016
Dual Incision in GG-NER	R-HSA-5696400	9.649664e-01	0.015
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.649664e-01	0.015
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.649664e-01	0.015
Signaling by NOTCH2	R-HSA-1980145	9.649664e-01	0.015
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.658735e-01	0.015
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.665067e-01	0.015
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	9.667896e-01	0.015
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.667896e-01	0.015
Attachment and Entry	R-HSA-9694614	9.667896e-01	0.015
Molybdenum cofactor biosynthesis	R-HSA-947581	9.667896e-01	0.015
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.667896e-01	0.015
Assembly Of The HIV Virion	R-HSA-175474	9.667896e-01	0.015
Glutathione synthesis and recycling	R-HSA-174403	9.667896e-01	0.015
Regulation of Apoptosis	R-HSA-169911	9.684911e-01	0.014
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.684911e-01	0.014
Deadenylation-dependent mRNA decay	R-HSA-429914	9.689066e-01	0.014
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.689596e-01	0.014
Leishmania parasite growth and survival	R-HSA-9664433	9.690443e-01	0.014
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.690443e-01	0.014
Interleukin-1 signaling	R-HSA-9020702	9.706831e-01	0.013
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.707276e-01	0.013
Biosynthesis of D-series resolvins	R-HSA-9018676	9.707276e-01	0.013
Ethanol oxidation	R-HSA-71384	9.707276e-01	0.013
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.707276e-01	0.013
Neurotoxicity of clostridium toxins	R-HSA-168799	9.707276e-01	0.013
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.715122e-01	0.013
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.716728e-01	0.012
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.720091e-01	0.012
Inositol phosphate metabolism	R-HSA-1483249	9.734832e-01	0.012
Regulation of PTEN mRNA translation	R-HSA-8943723	9.741988e-01	0.011
Mitochondrial mRNA modification	R-HSA-9937008	9.741988e-01	0.011
Degradation of DVL	R-HSA-4641258	9.745432e-01	0.011
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.745432e-01	0.011
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.745432e-01	0.011
TRAF6 mediated IRF7 activation	R-HSA-933541	9.745432e-01	0.011
Collagen chain trimerization	R-HSA-8948216	9.745432e-01	0.011
Mitochondrial protein degradation	R-HSA-9837999	9.759757e-01	0.011
Interferon gamma signaling	R-HSA-877300	9.763855e-01	0.010
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.766917e-01	0.010
Parasite infection	R-HSA-9664407	9.766917e-01	0.010
Leishmania phagocytosis	R-HSA-9664417	9.766917e-01	0.010
Elastic fibre formation	R-HSA-1566948	9.771314e-01	0.010
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.772586e-01	0.010
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.772586e-01	0.010
Synthesis of dolichyl-phosphate	R-HSA-446199	9.772586e-01	0.010
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.794640e-01	0.009
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.794640e-01	0.009
Stabilization of p53	R-HSA-69541	9.794640e-01	0.009
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.794640e-01	0.009
Activation of G protein gated Potassium channels	R-HSA-1296041	9.799556e-01	0.009
G protein gated Potassium channels	R-HSA-1296059	9.799556e-01	0.009
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.799556e-01	0.009
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.799556e-01	0.009
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.799556e-01	0.009
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.799556e-01	0.009
Toll-like Receptor Cascades	R-HSA-168898	9.802746e-01	0.009
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.808116e-01	0.008
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	9.808116e-01	0.008
Chaperonin-mediated protein folding	R-HSA-390466	9.811042e-01	0.008
Role of phospholipids in phagocytosis	R-HSA-2029485	9.812208e-01	0.008
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.815651e-01	0.008
MET activates PTK2 signaling	R-HSA-8874081	9.823330e-01	0.008
Urea cycle	R-HSA-70635	9.823330e-01	0.008
Sphingolipid catabolism	R-HSA-9845614	9.823330e-01	0.008
Selenoamino acid metabolism	R-HSA-2408522	9.824788e-01	0.008
Amino acids regulate mTORC1	R-HSA-9639288	9.825944e-01	0.008
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.844285e-01	0.007
Triglyceride biosynthesis	R-HSA-75109	9.844285e-01	0.007
Synthesis of PE	R-HSA-1483213	9.844285e-01	0.007
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.844285e-01	0.007
Signaling by BMP	R-HSA-201451	9.844285e-01	0.007
Maturation of hRSV A proteins	R-HSA-9828806	9.844285e-01	0.007
Metabolism of steroid hormones	R-HSA-196071	9.847634e-01	0.007
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.851593e-01	0.006
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.851593e-01	0.006
Heme biosynthesis	R-HSA-189451	9.851593e-01	0.006
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.860907e-01	0.006
Insulin receptor recycling	R-HSA-77387	9.862755e-01	0.006
Prednisone ADME	R-HSA-9757110	9.862755e-01	0.006
Pyrimidine salvage	R-HSA-73614	9.862755e-01	0.006
G alpha (i) signalling events	R-HSA-418594	9.867650e-01	0.006
Thyroxine biosynthesis	R-HSA-209968	9.879036e-01	0.005
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.879036e-01	0.005
Synthesis of PA	R-HSA-1483166	9.882635e-01	0.005
Protein folding	R-HSA-391251	9.883734e-01	0.005
Immune System	R-HSA-168256	9.887060e-01	0.005
Surfactant metabolism	R-HSA-5683826	9.893057e-01	0.005
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	9.893386e-01	0.005
Neurotransmitter clearance	R-HSA-112311	9.893386e-01	0.005
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.893386e-01	0.005
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	9.894440e-01	0.005
Regulation of mitotic cell cycle	R-HSA-453276	9.894440e-01	0.005
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.894440e-01	0.005
Metabolism of porphyrins	R-HSA-189445	9.894440e-01	0.005
Signaling by GPCR	R-HSA-372790	9.900456e-01	0.004
Collagen formation	R-HSA-1474290	9.901426e-01	0.004
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.903843e-01	0.004
Asymmetric localization of PCP proteins	R-HSA-4608870	9.904178e-01	0.004
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.906035e-01	0.004
Cargo concentration in the ER	R-HSA-5694530	9.906035e-01	0.004
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.909286e-01	0.004
SARS-CoV Infections	R-HSA-9679506	9.910960e-01	0.004
RAB geranylgeranylation	R-HSA-8873719	9.913010e-01	0.004
tRNA Aminoacylation	R-HSA-379724	9.913010e-01	0.004
Signaling by Retinoic Acid	R-HSA-5362517	9.913010e-01	0.004
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.916621e-01	0.004
Phospholipid metabolism	R-HSA-1483257	9.919125e-01	0.004
Signaling by NOTCH4	R-HSA-9013694	9.920165e-01	0.003
ROS and RNS production in phagocytes	R-HSA-1222556	9.920165e-01	0.003
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.923262e-01	0.003
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.923663e-01	0.003
Recycling of bile acids and salts	R-HSA-159418	9.927010e-01	0.003
Iron uptake and transport	R-HSA-917937	9.927315e-01	0.003
Peptide hormone metabolism	R-HSA-2980736	9.928104e-01	0.003
SARS-CoV-2-host interactions	R-HSA-9705683	9.929485e-01	0.003
Gluconeogenesis	R-HSA-70263	9.931183e-01	0.003
ER to Golgi Anterograde Transport	R-HSA-199977	9.931898e-01	0.003
CS/DS degradation	R-HSA-2024101	9.935671e-01	0.003
SARS-CoV-2 Infection	R-HSA-9694516	9.938665e-01	0.003
Neddylation	R-HSA-8951664	9.941664e-01	0.003
CD22 mediated BCR regulation	R-HSA-5690714	9.941927e-01	0.003
eNOS activation	R-HSA-203615	9.943304e-01	0.002
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.943304e-01	0.002
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.943304e-01	0.002
Calnexin/calreticulin cycle	R-HSA-901042	9.943304e-01	0.002
Hyaluronan metabolism	R-HSA-2142845	9.943304e-01	0.002
NPAS4 regulates expression of target genes	R-HSA-9768919	9.943304e-01	0.002
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.943368e-01	0.002
PCP/CE pathway	R-HSA-4086400	9.945263e-01	0.002
Interleukin-10 signaling	R-HSA-6783783	9.945263e-01	0.002
Acyl chain remodelling of PE	R-HSA-1482839	9.950033e-01	0.002
Transferrin endocytosis and recycling	R-HSA-917977	9.950033e-01	0.002
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.950690e-01	0.002
Activation of NF-kappaB in B cells	R-HSA-1169091	9.950690e-01	0.002
Hedgehog ligand biogenesis	R-HSA-5358346	9.950690e-01	0.002
Protein localization	R-HSA-9609507	9.955616e-01	0.002
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.955896e-01	0.002
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.955969e-01	0.002
SLC-mediated transport of amino acids	R-HSA-9958863	9.957252e-01	0.002
Nicotinate metabolism	R-HSA-196807	9.957252e-01	0.002
Nucleotide biosynthesis	R-HSA-8956320	9.960561e-01	0.002
Regulation of PTEN stability and activity	R-HSA-8948751	9.960561e-01	0.002
Degradation of AXIN	R-HSA-4641257	9.961189e-01	0.002
NCAM1 interactions	R-HSA-419037	9.961189e-01	0.002
Viral Infection Pathways	R-HSA-9824446	9.963209e-01	0.002
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.965796e-01	0.001
Purine salvage	R-HSA-74217	9.965796e-01	0.001
Paracetamol ADME	R-HSA-9753281	9.968484e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.968615e-01	0.001
RAS processing	R-HSA-9648002	9.969856e-01	0.001
Plasma lipoprotein clearance	R-HSA-8964043	9.969856e-01	0.001
Retinoid metabolism and transport	R-HSA-975634	9.971702e-01	0.001
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	9.971836e-01	0.001
Metabolism of amine-derived hormones	R-HSA-209776	9.971836e-01	0.001
tRNA processing	R-HSA-72306	9.973129e-01	0.001
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.973434e-01	0.001
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.973434e-01	0.001
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.974493e-01	0.001
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.976588e-01	0.001
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.976588e-01	0.001
Diseases of carbohydrate metabolism	R-HSA-5663084	9.977014e-01	0.001
Pyruvate metabolism	R-HSA-70268	9.979167e-01	0.001
Amino acid transport across the plasma membrane	R-HSA-352230	9.979924e-01	0.001
Glutathione conjugation	R-HSA-156590	9.982073e-01	0.001
Defensins	R-HSA-1461973	9.983976e-01	0.001
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.983976e-01	0.001
Response of Mtb to phagocytosis	R-HSA-9637690	9.983976e-01	0.001
Formation of paraxial mesoderm	R-HSA-9793380	9.983994e-01	0.001
Endogenous sterols	R-HSA-211976	9.983994e-01	0.001
Nucleotide salvage	R-HSA-8956321	9.983994e-01	0.001
Collagen degradation	R-HSA-1442490	9.983994e-01	0.001
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.985713e-01	0.001
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.985879e-01	0.001
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.985879e-01	0.001
Cholesterol biosynthesis	R-HSA-191273	9.986390e-01	0.001
Integrin cell surface interactions	R-HSA-216083	9.986390e-01	0.001
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.987556e-01	0.001
Somitogenesis	R-HSA-9824272	9.987556e-01	0.001
Degradation of cysteine and homocysteine	R-HSA-1614558	9.987556e-01	0.001
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.988488e-01	0.001
Interferon alpha/beta signaling	R-HSA-909733	9.988823e-01	0.000
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.989034e-01	0.000
Regulation of pyruvate metabolism	R-HSA-9861718	9.989034e-01	0.000
FCGR activation	R-HSA-2029481	9.989581e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.990090e-01	0.000
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.990336e-01	0.000
Synthesis of PC	R-HSA-1483191	9.990336e-01	0.000
Plasma lipoprotein remodeling	R-HSA-8963899	9.991484e-01	0.000
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.992495e-01	0.000
Keratan sulfate/keratin metabolism	R-HSA-1638074	9.992495e-01	0.000
Chemokine receptors bind chemokines	R-HSA-380108	9.992495e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.992797e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.993026e-01	0.000
Azathioprine ADME	R-HSA-9748787	9.993387e-01	0.000
SLC transporter disorders	R-HSA-5619102	9.993720e-01	0.000
Complex IV assembly	R-HSA-9864848	9.994172e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.994302e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.994372e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.994629e-01	0.000
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.994865e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.994897e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.994897e-01	0.000
ABC-family proteins mediated transport	R-HSA-382556	9.995349e-01	0.000
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.995475e-01	0.000
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.996012e-01	0.000
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.996271e-01	0.000
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.996486e-01	0.000
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.996486e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.996575e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.996783e-01	0.000
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.996783e-01	0.000
Digestion	R-HSA-8935690	9.996904e-01	0.000
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.997083e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.997210e-01	0.000
Antigen processing-Cross presentation	R-HSA-1236975	9.998153e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.998335e-01	0.000
Visual phototransduction	R-HSA-2187338	9.998637e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.998697e-01	0.000
Digestion and absorption	R-HSA-8963743	9.998723e-01	0.000
Post-translational protein phosphorylation	R-HSA-8957275	9.998857e-01	0.000
Xenobiotics	R-HSA-211981	9.998875e-01	0.000
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.999009e-01	0.000
Transport to the Golgi and subsequent modification	R-HSA-948021	9.999128e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.999230e-01	0.000
Classical antibody-mediated complement activation	R-HSA-173623	9.999370e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999370e-01	0.000
ER-Phagosome pathway	R-HSA-1236974	9.999439e-01	0.000
RSV-host interactions	R-HSA-9833110	9.999472e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999473e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999473e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.999474e-01	0.000
Downstream TCR signaling	R-HSA-202424	9.999501e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999501e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.999524e-01	0.000
Innate Immune System	R-HSA-168249	9.999664e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999690e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999757e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999781e-01	0.000
ABC transporter disorders	R-HSA-5619084	9.999809e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999809e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999832e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999845e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999864e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999869e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999939e-01	0.000
Creation of C4 and C2 activators	R-HSA-166786	9.999947e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999950e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999955e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999960e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999962e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999967e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999979e-01	0.000
Initial triggering of complement	R-HSA-166663	9.999982e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.999985e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999993e-01	0.000
Translation	R-HSA-72766	9.999994e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999995e-01	0.000
Infectious disease	R-HSA-5663205	9.999997e-01	0.000
Complement cascade	R-HSA-166658	9.999997e-01	0.000
Disease	R-HSA-1643685	9.999998e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999999e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999999e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999999e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cellular response to heat stress	R-HSA-3371556	1.110223e-16	15.955
M Phase	R-HSA-68886	1.110223e-16	15.955
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955
Cell Cycle, Mitotic	R-HSA-69278	1.110223e-16	15.955
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955
Attenuation phase	R-HSA-3371568	2.220446e-16	15.654
HSF1-dependent transactivation	R-HSA-3371571	3.330669e-16	15.477
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	6.661338e-16	15.176
Eukaryotic Translation Initiation	R-HSA-72613	2.664535e-15	14.574
Cap-dependent Translation Initiation	R-HSA-72737	2.664535e-15	14.574
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.886580e-15	14.540
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.219647e-14	13.492
Axon guidance	R-HSA-422475	6.017409e-14	13.221
Metabolism of RNA	R-HSA-8953854	4.315437e-13	12.365
Eukaryotic Translation Elongation	R-HSA-156842	4.941603e-13	12.306
HSF1 activation	R-HSA-3371511	4.948264e-13	12.306
Nervous system development	R-HSA-9675108	1.326717e-12	11.877
Formation of a pool of free 40S subunits	R-HSA-72689	1.522893e-12	11.817
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.611267e-12	11.793
Recycling pathway of L1	R-HSA-437239	2.771894e-12	11.557
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	8.399503e-12	11.076
Peptide chain elongation	R-HSA-156902	9.596102e-12	11.018
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.527934e-12	11.021
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.527934e-12	11.021
Signaling by ROBO receptors	R-HSA-376176	1.157041e-11	10.937
Cell-Cell communication	R-HSA-1500931	2.365153e-11	10.626
Transcriptional regulation by small RNAs	R-HSA-5578749	2.584366e-11	10.588
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.994871e-11	10.398
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	7.852219e-11	10.105
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	8.990375e-11	10.046
Mitotic Prophase	R-HSA-68875	9.144607e-11	10.039
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.772272e-11	10.057
Cell junction organization	R-HSA-446728	1.098091e-10	9.959
PRC2 methylates histones and DNA	R-HSA-212300	1.308764e-10	9.883
DNA methylation	R-HSA-5334118	1.368750e-10	9.864
Influenza Infection	R-HSA-168255	1.400750e-10	9.854
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.533446e-10	9.814
rRNA processing in the nucleus and cytosol	R-HSA-8868773	2.112389e-10	9.675
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.257944e-10	9.646
HCMV Early Events	R-HSA-9609690	2.643880e-10	9.578
Mitotic Anaphase	R-HSA-68882	3.025957e-10	9.519
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	3.454196e-10	9.462
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.509898e-10	9.455
Eukaryotic Translation Termination	R-HSA-72764	3.846895e-10	9.415
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.711657e-10	9.327
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	5.284000e-10	9.277
Defective pyroptosis	R-HSA-9710421	5.530937e-10	9.257
Aggrephagy	R-HSA-9646399	6.642726e-10	9.178
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.642726e-10	9.178
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	6.642726e-10	9.178
Separation of Sister Chromatids	R-HSA-2467813	7.365890e-10	9.133
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.166612e-10	9.145
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	8.513734e-10	9.070
Translation initiation complex formation	R-HSA-72649	9.527078e-10	9.021
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.305771e-09	8.884
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.305771e-09	8.884
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.318053e-09	8.880
Apoptotic execution phase	R-HSA-75153	1.604649e-09	8.795
Ribosomal scanning and start codon recognition	R-HSA-72702	1.783505e-09	8.749
Ribosome-associated quality control	R-HSA-9948299	1.723352e-09	8.764
Viral Infection Pathways	R-HSA-9824446	2.124958e-09	8.673
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.190172e-09	8.660
Packaging Of Telomere Ends	R-HSA-171306	2.293870e-09	8.639
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.370265e-09	8.625
RNA Polymerase I Promoter Opening	R-HSA-73728	2.293870e-09	8.639
Meiotic synapsis	R-HSA-1221632	3.260275e-09	8.487
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.258363e-09	8.487
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	3.346996e-09	8.475
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.615222e-09	8.442
Mitotic Prometaphase	R-HSA-68877	3.604955e-09	8.443
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	4.259467e-09	8.371
Assembly of the ORC complex at the origin of replication	R-HSA-68616	5.048051e-09	8.297
Regulation of CDH1 Gene Transcription	R-HSA-9764560	5.069327e-09	8.295
Selenocysteine synthesis	R-HSA-2408557	5.317834e-09	8.274
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	5.495346e-09	8.260
HDACs deacetylate histones	R-HSA-3214815	5.987356e-09	8.223
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	6.577893e-09	8.182
Gene Silencing by RNA	R-HSA-211000	6.605483e-09	8.180
Viral mRNA Translation	R-HSA-192823	8.065562e-09	8.093
Assembly of the pre-replicative complex	R-HSA-68867	9.505752e-09	8.022
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.093408e-08	7.961
Estrogen-dependent gene expression	R-HSA-9018519	1.130998e-08	7.947
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.106808e-08	7.956
HCMV Infection	R-HSA-9609646	1.171496e-08	7.931
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.219403e-08	7.914
Cell Cycle Checkpoints	R-HSA-69620	1.280773e-08	7.893
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.495700e-08	7.825
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.480003e-08	7.830
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.083563e-08	7.681
Interleukin-12 signaling	R-HSA-9020591	2.272775e-08	7.643
SIRT1 negatively regulates rRNA expression	R-HSA-427359	3.305724e-08	7.481
DNA Replication Pre-Initiation	R-HSA-69002	3.207003e-08	7.494
Cleavage of the damaged purine	R-HSA-110331	3.305724e-08	7.481
Diseases of programmed cell death	R-HSA-9645723	3.235603e-08	7.490
Transport of connexons to the plasma membrane	R-HSA-190872	3.578830e-08	7.446
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	3.846569e-08	7.415
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	3.861967e-08	7.413
rRNA processing	R-HSA-72312	4.525804e-08	7.344
Depurination	R-HSA-73927	4.665332e-08	7.331
Adherens junctions interactions	R-HSA-418990	4.785770e-08	7.320
Meiosis	R-HSA-1500620	4.808796e-08	7.318
Cellular response to starvation	R-HSA-9711097	5.402638e-08	7.267
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	5.717620e-08	7.243
G2/M Transition	R-HSA-69275	6.627638e-08	7.179
Cell-cell junction organization	R-HSA-421270	7.560942e-08	7.121
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.815154e-08	7.107
Mitotic G2-G2/M phases	R-HSA-453274	8.671572e-08	7.062
Post NMDA receptor activation events	R-HSA-438064	9.108085e-08	7.041
Kinesins	R-HSA-983189	1.006985e-07	6.997
Selective autophagy	R-HSA-9663891	1.120012e-07	6.951
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.141544e-07	6.943
Nucleosome assembly	R-HSA-774815	1.241046e-07	6.906
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.241046e-07	6.906
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.241703e-07	6.906
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	1.241703e-07	6.906
Meiotic recombination	R-HSA-912446	1.571551e-07	6.804
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.661601e-07	6.779
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.661601e-07	6.779
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.691896e-07	6.772
Cellular Senescence	R-HSA-2559583	1.951917e-07	6.710
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.000714e-07	6.699
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.029902e-07	6.693
Regulation of endogenous retroelements	R-HSA-9842860	2.315769e-07	6.635
Oxidative Stress Induced Senescence	R-HSA-2559580	2.315769e-07	6.635
Cleavage of the damaged pyrimidine	R-HSA-110329	2.287185e-07	6.641
Depyrimidination	R-HSA-73928	2.287185e-07	6.641
Interleukin-12 family signaling	R-HSA-447115	3.076550e-07	6.512
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	3.086829e-07	6.510
G2/M Checkpoints	R-HSA-69481	3.914012e-07	6.407
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.936563e-07	6.405
HATs acetylate histones	R-HSA-3214847	4.195722e-07	6.377
L1CAM interactions	R-HSA-373760	4.746855e-07	6.324
Apoptotic cleavage of cellular proteins	R-HSA-111465	5.409837e-07	6.267
Post-chaperonin tubulin folding pathway	R-HSA-389977	6.290212e-07	6.201
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.101273e-07	6.149
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	6.698888e-07	6.174
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	7.129643e-07	6.147
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	8.361611e-07	6.078
Telomere Maintenance	R-HSA-157579	9.065202e-07	6.043
Signaling by WNT	R-HSA-195721	9.395843e-07	6.027
Chaperonin-mediated protein folding	R-HSA-390466	1.002602e-06	5.999
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.202196e-06	5.920
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.207957e-06	5.918
DNA Replication	R-HSA-69306	1.309554e-06	5.883
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.360563e-06	5.866
Interferon Signaling	R-HSA-913531	1.533968e-06	5.814
Gap junction trafficking and regulation	R-HSA-157858	1.549935e-06	5.810
Gap junction trafficking	R-HSA-190828	1.724709e-06	5.763
DNA Double Strand Break Response	R-HSA-5693606	1.904826e-06	5.720
Translation	R-HSA-72766	2.188983e-06	5.660
ESR-mediated signaling	R-HSA-8939211	2.272203e-06	5.644
PKR-mediated signaling	R-HSA-9833482	2.286230e-06	5.641
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.304857e-06	5.637
Chromosome Maintenance	R-HSA-73886	2.879981e-06	5.541
Condensation of Prophase Chromosomes	R-HSA-2299718	2.887463e-06	5.539
Protein folding	R-HSA-391251	2.945962e-06	5.531
Ub-specific processing proteases	R-HSA-5689880	3.011185e-06	5.521
RNA Polymerase I Promoter Escape	R-HSA-73772	3.209884e-06	5.494
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.322031e-06	5.479
TCF dependent signaling in response to WNT	R-HSA-201681	4.093041e-06	5.388
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	4.826167e-06	5.316
Autophagy	R-HSA-9612973	4.797064e-06	5.319
Base Excision Repair	R-HSA-73884	5.298800e-06	5.276
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.679569e-06	5.246
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	6.325398e-06	5.199
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	6.435247e-06	5.191
Signal Transduction	R-HSA-162582	7.333184e-06	5.135
Processing of DNA double-strand break ends	R-HSA-5693607	8.633120e-06	5.064
Amyloid fiber formation	R-HSA-977225	8.633120e-06	5.064
ISG15 antiviral mechanism	R-HSA-1169408	9.148781e-06	5.039
Chaperone Mediated Autophagy	R-HSA-9613829	9.757778e-06	5.011
Cell-extracellular matrix interactions	R-HSA-446353	1.092570e-05	4.962
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.096399e-05	4.960
Selenoamino acid metabolism	R-HSA-2408522	1.239859e-05	4.907
HIV Life Cycle	R-HSA-162587	1.298977e-05	4.886
Homology Directed Repair	R-HSA-5693538	1.328849e-05	4.877
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.663192e-05	4.779
RNA Polymerase I Transcription	R-HSA-73864	1.560179e-05	4.807
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.588879e-05	4.799
HIV Infection	R-HSA-162906	1.817731e-05	4.740
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.820743e-05	4.740
DNA Double-Strand Break Repair	R-HSA-5693532	1.925054e-05	4.716
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.248242e-05	4.648
Apoptosis	R-HSA-109581	2.293709e-05	4.639
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.577884e-05	4.589
Activation of HOX genes during differentiation	R-HSA-5619507	2.614179e-05	4.583
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.614179e-05	4.583
Gap junction assembly	R-HSA-190861	2.722889e-05	4.565
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	2.769967e-05	4.558
Cytokine Signaling in Immune system	R-HSA-1280215	2.918242e-05	4.535
Host Interactions of HIV factors	R-HSA-162909	2.929440e-05	4.533
Reproduction	R-HSA-1474165	3.227755e-05	4.491
Nuclear Envelope Breakdown	R-HSA-2980766	3.303119e-05	4.481
SARS-CoV-1-host interactions	R-HSA-9692914	3.454920e-05	4.462
Membrane Trafficking	R-HSA-199991	3.507822e-05	4.455
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.094281e-05	4.388
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.960740e-05	4.402
Signaling by ALK in cancer	R-HSA-9700206	3.960740e-05	4.402
NoRC negatively regulates rRNA expression	R-HSA-427413	4.280617e-05	4.368
Macroautophagy	R-HSA-1632852	5.567396e-05	4.254
Signaling by NOTCH	R-HSA-157118	5.844146e-05	4.233
mRNA Splicing - Major Pathway	R-HSA-72163	6.356978e-05	4.197
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	6.376857e-05	4.195
Chromatin modifying enzymes	R-HSA-3247509	6.995199e-05	4.155
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	7.098755e-05	4.149
Regulation of PD-L1(CD274) expression	R-HSA-9909648	7.307101e-05	4.136
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.455860e-05	4.128
Developmental Biology	R-HSA-1266738	9.243119e-05	4.034
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	9.819075e-05	4.008
Interactions of Rev with host cellular proteins	R-HSA-177243	1.136207e-04	3.945
p75NTR recruits signalling complexes	R-HSA-209543	1.156658e-04	3.937
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.260688e-04	3.899
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.721875e-04	3.764
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.557372e-04	3.808
Amplification of signal from the kinetochores	R-HSA-141424	1.557372e-04	3.808
mRNA Splicing	R-HSA-72172	1.720211e-04	3.764
Late Phase of HIV Life Cycle	R-HSA-162599	1.574264e-04	3.803
HCMV Late Events	R-HSA-9610379	1.509225e-04	3.821
SARS-CoV-2-host interactions	R-HSA-9705683	1.657225e-04	3.781
Epigenetic regulation of gene expression	R-HSA-212165	1.982702e-04	3.703
G2/M DNA damage checkpoint	R-HSA-69473	2.003617e-04	3.698
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	2.121806e-04	3.673
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	2.121806e-04	3.673
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	2.121806e-04	3.673
Golgi-to-ER retrograde transport	R-HSA-8856688	2.222031e-04	3.653
Co-inhibition by PD-1	R-HSA-389948	2.244927e-04	3.649
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.244927e-04	3.649
Chromatin organization	R-HSA-4839726	2.352371e-04	3.628
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.358895e-04	3.627
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.555265e-04	3.593
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.624603e-04	3.581
Transcriptional regulation by RUNX1	R-HSA-8878171	2.738738e-04	3.562
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.109246e-04	3.507
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	3.130905e-04	3.504
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.197862e-04	3.495
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.224449e-04	3.492
Transcriptional Regulation by E2F6	R-HSA-8953750	3.224449e-04	3.492
COPI-mediated anterograde transport	R-HSA-6807878	3.395627e-04	3.469
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.630312e-04	3.440
Late endosomal microautophagy	R-HSA-9615710	3.818179e-04	3.418
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	3.937315e-04	3.405
Nuclear import of Rev protein	R-HSA-180746	3.972366e-04	3.401
p75NTR signals via NF-kB	R-HSA-193639	3.630312e-04	3.440
Deubiquitination	R-HSA-5688426	3.679318e-04	3.434
Regulation of T cell activation by CD28 family	R-HSA-388841	3.956239e-04	3.403
Programmed Cell Death	R-HSA-5357801	3.702551e-04	3.431
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.994572e-04	3.399
Signaling downstream of RAS mutants	R-HSA-9649948	4.523622e-04	3.345
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	4.523622e-04	3.345
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	4.523622e-04	3.345
Signaling by RAS mutants	R-HSA-6802949	4.523622e-04	3.345
FLT3 signaling by CBL mutants	R-HSA-9706377	4.587046e-04	3.338
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	4.592928e-04	3.338
Pre-NOTCH Expression and Processing	R-HSA-1912422	4.912188e-04	3.309
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	5.100337e-04	3.292
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	5.398296e-04	3.268
Mitotic Spindle Checkpoint	R-HSA-69618	5.486350e-04	3.261
Glycolysis	R-HSA-70171	5.486350e-04	3.261
Signaling by RAF1 mutants	R-HSA-9656223	5.770216e-04	3.239
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	6.002670e-04	3.222
Protein ubiquitination	R-HSA-8852135	6.214967e-04	3.207
Muscle contraction	R-HSA-397014	6.424466e-04	3.192
Infectious disease	R-HSA-5663205	6.641387e-04	3.178
DNA Repair	R-HSA-73894	6.752064e-04	3.171
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	6.839439e-04	3.165
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	6.934031e-04	3.159
Metalloprotease DUBs	R-HSA-5689901	7.218813e-04	3.142
Vpr-mediated nuclear import of PICs	R-HSA-180910	7.306888e-04	3.136
MHC class II antigen presentation	R-HSA-2132295	7.743370e-04	3.111
Oncogenic MAPK signaling	R-HSA-6802957	8.945617e-04	3.048
Regulation of MECP2 expression and activity	R-HSA-9022692	9.160467e-04	3.038
Regulation of CDH1 Function	R-HSA-9764561	9.308137e-04	3.031
Membrane binding and targetting of GAG proteins	R-HSA-174490	9.481801e-04	3.023
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.075522e-03	2.968
Striated Muscle Contraction	R-HSA-390522	1.118697e-03	2.951
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.222911e-03	2.913
Folding of actin by CCT/TriC	R-HSA-390450	1.222911e-03	2.913
Apoptosis induced DNA fragmentation	R-HSA-140342	1.222911e-03	2.913
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.271627e-03	2.896
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.311836e-03	2.882
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.394329e-03	2.856
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.635208e-03	2.786
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.461025e-03	2.835
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.370718e-03	2.863
Smooth Muscle Contraction	R-HSA-445355	1.423853e-03	2.847
SARS-CoV-1 Infection	R-HSA-9678108	1.634422e-03	2.787
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.715673e-03	2.766
Downregulation of ERBB2 signaling	R-HSA-8863795	1.715673e-03	2.766
tRNA processing in the nucleus	R-HSA-6784531	1.894965e-03	2.722
Death Receptor Signaling	R-HSA-73887	2.062132e-03	2.686
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.087470e-03	2.680
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.087470e-03	2.680
DNA Damage Bypass	R-HSA-73893	2.181718e-03	2.661
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	2.187877e-03	2.660
Regulation of PTEN localization	R-HSA-8948747	2.196950e-03	2.658
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.331887e-03	2.632
NF-kB is activated and signals survival	R-HSA-209560	2.489146e-03	2.604
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	2.612476e-03	2.583
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	2.612476e-03	2.583
Hedgehog 'off' state	R-HSA-5610787	2.830183e-03	2.548
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	3.020048e-03	2.520
IPs transport between nucleus and cytosol	R-HSA-1855170	3.025090e-03	2.519
AURKA Activation by TPX2	R-HSA-8854518	3.167732e-03	2.499
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.219851e-03	2.492
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.251496e-03	2.488
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.274272e-03	2.485
Assembly Of The HIV Virion	R-HSA-175474	3.274272e-03	2.485
Myoclonic epilepsy of Lafora	R-HSA-3785653	3.292512e-03	2.482
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.292512e-03	2.482
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.292512e-03	2.482
Beta-catenin independent WNT signaling	R-HSA-3858494	3.299681e-03	2.482
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.349528e-03	2.475
IRAK1 recruits IKK complex	R-HSA-937039	3.405650e-03	2.468
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.405650e-03	2.468
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	3.405650e-03	2.468
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	3.405650e-03	2.468
Signaling by Nuclear Receptors	R-HSA-9006931	3.442148e-03	2.463
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	3.605693e-03	2.443
Neutrophil degranulation	R-HSA-6798695	3.731187e-03	2.428
Signaling by ERBB2	R-HSA-1227986	3.731779e-03	2.428
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.783581e-03	2.422
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	3.783581e-03	2.422
Centrosome maturation	R-HSA-380287	3.801253e-03	2.420
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.059320e-03	2.392
Mitotic G1 phase and G1/S transition	R-HSA-453279	4.076230e-03	2.390
Glucose metabolism	R-HSA-70326	4.106627e-03	2.387
Dual Incision in GG-NER	R-HSA-5696400	4.271291e-03	2.369
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	5.382935e-03	2.269
Loss of Nlp from mitotic centrosomes	R-HSA-380259	5.382935e-03	2.269
MAP2K and MAPK activation	R-HSA-5674135	5.154277e-03	2.288
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	4.734690e-03	2.325
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	4.734690e-03	2.325
ER to Golgi Anterograde Transport	R-HSA-199977	4.399074e-03	2.357
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.552126e-03	2.342
Signaling by PTK6	R-HSA-8848021	5.382935e-03	2.269
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.382935e-03	2.269
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	4.382040e-03	2.358
p75 NTR receptor-mediated signalling	R-HSA-193704	5.486530e-03	2.261
TNF signaling	R-HSA-75893	5.654172e-03	2.248
Vesicle-mediated transport	R-HSA-5653656	5.658871e-03	2.247
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	5.699192e-03	2.244
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	5.716718e-03	2.243
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	5.716718e-03	2.243
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	5.716718e-03	2.243
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	5.716718e-03	2.243
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	5.716718e-03	2.243
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	5.716718e-03	2.243
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	5.716718e-03	2.243
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	5.716718e-03	2.243
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	5.716718e-03	2.243
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	5.716718e-03	2.243
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	5.716718e-03	2.243
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	5.954333e-03	2.225
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	5.960199e-03	2.225
NRIF signals cell death from the nucleus	R-HSA-205043	5.960199e-03	2.225
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.023292e-03	2.220
Maturation of protein E	R-HSA-9694493	6.023292e-03	2.220
Maturation of protein E	R-HSA-9683683	6.023292e-03	2.220
Regulation of signaling by CBL	R-HSA-912631	6.264422e-03	2.203
Translesion Synthesis by POLH	R-HSA-110320	6.264422e-03	2.203
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	6.576611e-03	2.182
Josephin domain DUBs	R-HSA-5689877	6.576611e-03	2.182
Pexophagy	R-HSA-9664873	6.576611e-03	2.182
Budding and maturation of HIV virion	R-HSA-162588	6.633117e-03	2.178
SARS-CoV-2 Infection	R-HSA-9694516	6.707789e-03	2.173
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	6.848887e-03	2.164
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	6.862126e-03	2.164
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	7.661564e-03	2.116
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	7.661564e-03	2.116
Translesion synthesis by REV1	R-HSA-110312	7.661564e-03	2.116
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	7.661564e-03	2.116
Spry regulation of FGF signaling	R-HSA-1295596	7.661564e-03	2.116
DNA strand elongation	R-HSA-69190	7.811426e-03	2.107
RMTs methylate histone arginines	R-HSA-3214858	7.845183e-03	2.105
snRNP Assembly	R-HSA-191859	8.097884e-03	2.092
Metabolism of non-coding RNA	R-HSA-194441	8.097884e-03	2.092
Cilium Assembly	R-HSA-5617833	8.355640e-03	2.078
Orc1 removal from chromatin	R-HSA-68949	8.570636e-03	2.067
Signaling by EGFR in Cancer	R-HSA-1643713	8.725562e-03	2.059
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	8.869631e-03	2.052
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	8.869631e-03	2.052
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	9.450589e-03	2.025
Signaling by TGF-beta Receptor Complex	R-HSA-170834	9.460057e-03	2.024
UCH proteinases	R-HSA-5689603	9.568672e-03	2.019
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	9.620850e-03	2.017
Translesion synthesis by POLI	R-HSA-5656121	9.687508e-03	2.014
Negative regulation of FLT3	R-HSA-9706369	9.687508e-03	2.014
Regulation of TNFR1 signaling	R-HSA-5357905	1.017268e-02	1.993
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.399722e-02	1.854
Diseases of Telomere Maintenance	R-HSA-9673013	1.399722e-02	1.854
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.399722e-02	1.854
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.399722e-02	1.854
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.399722e-02	1.854
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.399722e-02	1.854
Disorders of Developmental Biology	R-HSA-9675151	1.206844e-02	1.918
Translesion synthesis by POLK	R-HSA-5655862	1.206844e-02	1.918
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.142610e-02	1.942
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.063890e-02	1.973
Signaling by EGFR	R-HSA-177929	1.360672e-02	1.866
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	1.231163e-02	1.910
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.053066e-02	1.978
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.142610e-02	1.942
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.108620e-02	1.955
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.166226e-02	1.933
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.075284e-02	1.968
PKMTs methylate histone lysines	R-HSA-3214841	1.203595e-02	1.920
Intraflagellar transport	R-HSA-5620924	1.299714e-02	1.886
Negative regulation of MAPK pathway	R-HSA-5675221	1.369806e-02	1.863
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.368426e-02	1.864
Signaling by Hedgehog	R-HSA-5358351	1.352502e-02	1.869
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.203595e-02	1.920
Signaling by Interleukins	R-HSA-449147	1.267520e-02	1.897
Termination of translesion DNA synthesis	R-HSA-5656169	1.425442e-02	1.846
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	1.425442e-02	1.846
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.461482e-02	1.835
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.499925e-02	1.824
Disorders of Nervous System Development	R-HSA-9697154	1.499925e-02	1.824
Pervasive developmental disorders	R-HSA-9005895	1.499925e-02	1.824
Polymerase switching	R-HSA-69091	1.499925e-02	1.824
Leading Strand Synthesis	R-HSA-69109	1.499925e-02	1.824
VLDLR internalisation and degradation	R-HSA-8866427	1.499925e-02	1.824
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.545960e-02	1.811
S Phase	R-HSA-69242	1.565443e-02	1.805
G1/S Transition	R-HSA-69206	1.590162e-02	1.799
FLT3 signaling in disease	R-HSA-9682385	1.623371e-02	1.790
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.623598e-02	1.790
SARS-CoV Infections	R-HSA-9679506	1.708131e-02	1.767
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.752040e-02	1.756
Formation of annular gap junctions	R-HSA-196025	1.752040e-02	1.756
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.752040e-02	1.756
Downregulation of ERBB4 signaling	R-HSA-1253288	1.752040e-02	1.756
Modulation by Mtb of host immune system	R-HSA-9637628	1.752040e-02	1.756
Platelet sensitization by LDL	R-HSA-432142	1.801002e-02	1.744
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.801002e-02	1.744
Platelet degranulation	R-HSA-114608	1.823556e-02	1.739
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.858754e-02	1.731
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.873973e-02	1.727
Deadenylation of mRNA	R-HSA-429947	1.912787e-02	1.718
EGFR downregulation	R-HSA-182971	1.913427e-02	1.718
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.913427e-02	1.718
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.913427e-02	1.718
mRNA 3'-end processing	R-HSA-72187	2.038081e-02	1.691
MAPK family signaling cascades	R-HSA-5683057	2.108765e-02	1.676
MAPK6/MAPK4 signaling	R-HSA-5687128	2.162229e-02	1.665
IKK complex recruitment mediated by RIP1	R-HSA-937041	2.162345e-02	1.665
G0 and Early G1	R-HSA-1538133	2.197561e-02	1.658
Synthesis of DNA	R-HSA-69239	2.251262e-02	1.648
Organelle biogenesis and maintenance	R-HSA-1852241	2.268153e-02	1.644
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.317785e-02	1.635
Gap junction degradation	R-HSA-190873	2.317785e-02	1.635
Unwinding of DNA	R-HSA-176974	2.317785e-02	1.635
Regulation of KIT signaling	R-HSA-1433559	2.346229e-02	1.630
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.346229e-02	1.630
PCP/CE pathway	R-HSA-4086400	2.414903e-02	1.617
G alpha (12/13) signalling events	R-HSA-416482	2.414903e-02	1.617
Activation of ATR in response to replication stress	R-HSA-176187	2.510243e-02	1.600
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.569679e-02	1.590
Negative regulation of MET activity	R-HSA-6807004	2.569679e-02	1.590
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.593043e-02	1.586
Semaphorin interactions	R-HSA-373755	2.745622e-02	1.561
rRNA modification in the nucleus and cytosol	R-HSA-6790901	2.745622e-02	1.561
Immune System	R-HSA-168256	2.794454e-02	1.554
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.852718e-02	1.545
IRF3-mediated induction of type I IFN	R-HSA-3270619	2.865320e-02	1.543
Protein methylation	R-HSA-8876725	2.865320e-02	1.543
Manipulation of host energy metabolism	R-HSA-9636667	2.971973e-02	1.527
Breakdown of the nuclear lamina	R-HSA-352238	2.971973e-02	1.527
MET activates RAP1 and RAC1	R-HSA-8875555	2.982655e-02	1.525
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.992423e-02	1.524
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.992423e-02	1.524
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.025048e-02	1.519
Early Phase of HIV Life Cycle	R-HSA-162594	3.025048e-02	1.519
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	3.025048e-02	1.519
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	3.047258e-02	1.516
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	3.047258e-02	1.516
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.048766e-02	1.516
Switching of origins to a post-replicative state	R-HSA-69052	3.193166e-02	1.496
RAF activation	R-HSA-5673000	3.226144e-02	1.491
Clathrin-mediated endocytosis	R-HSA-8856828	3.399049e-02	1.469
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.422159e-02	1.466
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.530213e-02	1.452
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	3.530213e-02	1.452
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.532109e-02	1.452
Nucleotide Excision Repair	R-HSA-5696398	3.578834e-02	1.446
Regulation of Apoptosis	R-HSA-169911	3.631584e-02	1.440
Platelet activation, signaling and aggregation	R-HSA-76002	3.643792e-02	1.438
Intracellular signaling by second messengers	R-HSA-9006925	3.652978e-02	1.437
Dual incision in TC-NER	R-HSA-6782135	3.667164e-02	1.436
Transcriptional Regulation by MECP2	R-HSA-8986944	3.705064e-02	1.431
Ca-dependent events	R-HSA-111996	3.716840e-02	1.430
Regulation of RAS by GAPs	R-HSA-5658442	3.719530e-02	1.430
PECAM1 interactions	R-HSA-210990	3.749139e-02	1.426
Signaling by ERBB2 ECD mutants	R-HSA-9665348	5.630104e-02	1.249
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.630104e-02	1.249
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.486023e-02	1.348
RNA Polymerase II Transcription Termination	R-HSA-73856	4.754599e-02	1.323
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	5.825146e-02	1.235
Activation of the pre-replicative complex	R-HSA-68962	4.410684e-02	1.355
Integration of provirus	R-HSA-162592	4.618321e-02	1.336
CaM pathway	R-HSA-111997	4.069993e-02	1.390
DAG and IP3 signaling	R-HSA-1489509	5.014019e-02	1.300
Calmodulin induced events	R-HSA-111933	4.069993e-02	1.390
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.946956e-02	1.306
Asymmetric localization of PCP proteins	R-HSA-4608870	5.014019e-02	1.300
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.370411e-02	1.359
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.370411e-02	1.359
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.370411e-02	1.359
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.370411e-02	1.359
Ovarian tumor domain proteases	R-HSA-5689896	4.542218e-02	1.343
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	4.107320e-02	1.386
RAF/MAP kinase cascade	R-HSA-5673001	4.489427e-02	1.348
Opioid Signalling	R-HSA-111885	5.557853e-02	1.255
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	4.107320e-02	1.386
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	5.014019e-02	1.300
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	5.014019e-02	1.300
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.349950e-02	1.362
MAPK1/MAPK3 signaling	R-HSA-5684996	5.803986e-02	1.236
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	4.988130e-02	1.302
Viral Messenger RNA Synthesis	R-HSA-168325	4.754599e-02	1.323
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.370411e-02	1.359
Evasion by RSV of host interferon responses	R-HSA-9833109	4.967269e-02	1.304
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	4.542218e-02	1.343
Nef and signal transduction	R-HSA-164944	4.718351e-02	1.326
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.618321e-02	1.336
Glycogen storage diseases	R-HSA-3229121	4.833232e-02	1.316
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	5.137180e-02	1.289
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	4.946956e-02	1.306
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	5.589975e-02	1.253
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	5.589975e-02	1.253
Signaling by NOTCH3	R-HSA-9012852	5.825146e-02	1.235
Disease	R-HSA-1643685	4.150714e-02	1.382
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	4.107320e-02	1.386
Response of Mtb to phagocytosis	R-HSA-9637690	4.120454e-02	1.385
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	6.026451e-02	1.220
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.073560e-02	1.217
Uptake and function of diphtheria toxin	R-HSA-5336415	6.074420e-02	1.216
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.168441e-02	1.210
Ca2+ pathway	R-HSA-4086398	6.182354e-02	1.209
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	6.208552e-02	1.207
Regulation of necroptotic cell death	R-HSA-5675482	6.208552e-02	1.207
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	6.263004e-02	1.203
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.295907e-02	1.201
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	6.323803e-02	1.199
Ion homeostasis	R-HSA-5578775	6.323803e-02	1.199
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.497981e-02	1.187
STING mediated induction of host immune responses	R-HSA-1834941	6.497981e-02	1.187
Gluconeogenesis	R-HSA-70263	6.578323e-02	1.182
Signaling by NOTCH4	R-HSA-9013694	6.635723e-02	1.178
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	6.662687e-02	1.176
Hh mutants are degraded by ERAD	R-HSA-5362768	6.781958e-02	1.169
Vpu mediated degradation of CD4	R-HSA-180534	6.894060e-02	1.162
PTEN Regulation	R-HSA-6807070	6.932748e-02	1.159
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	7.110291e-02	1.148
Developmental Cell Lineages	R-HSA-9734767	7.296599e-02	1.137
Adaptive Immune System	R-HSA-1280218	7.314676e-02	1.136
Axonal growth stimulation	R-HSA-209563	7.361565e-02	1.133
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	7.361565e-02	1.133
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.431670e-02	1.129
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.431670e-02	1.129
Translation of Structural Proteins	R-HSA-9683701	7.431670e-02	1.129
Glycogen synthesis	R-HSA-3322077	7.436363e-02	1.129
Protein hydroxylation	R-HSA-9629569	7.436363e-02	1.129
Nephrin family interactions	R-HSA-373753	7.436363e-02	1.129
Type I hemidesmosome assembly	R-HSA-446107	7.590498e-02	1.120
Adrenoceptors	R-HSA-390696	7.590498e-02	1.120
Signaling by NOTCH1	R-HSA-1980143	7.606243e-02	1.119
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	7.623028e-02	1.118
Mitophagy	R-HSA-5205647	7.623028e-02	1.118
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.623028e-02	1.118
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.623028e-02	1.118
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	7.667407e-02	1.115
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.667407e-02	1.115
Removal of the Flap Intermediate	R-HSA-69166	7.833969e-02	1.106
Interleukin-1 signaling	R-HSA-9020702	7.960169e-02	1.099
Signaling by TGFB family members	R-HSA-9006936	7.965596e-02	1.099
Signaling by VEGF	R-HSA-194138	7.976167e-02	1.098
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	8.088294e-02	1.092
MTOR signalling	R-HSA-165159	8.117664e-02	1.091
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	8.117664e-02	1.091
TCR signaling	R-HSA-202403	8.284229e-02	1.082
MyD88-independent TLR4 cascade	R-HSA-166166	8.284229e-02	1.082
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	8.284229e-02	1.082
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.395376e-02	1.076
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	8.395376e-02	1.076
Oncogene Induced Senescence	R-HSA-2559585	8.395376e-02	1.076
Activation of NF-kappaB in B cells	R-HSA-1169091	8.419553e-02	1.075
Hedgehog ligand biogenesis	R-HSA-5358346	8.419553e-02	1.075
Lagging Strand Synthesis	R-HSA-69186	8.444232e-02	1.073
G-protein activation	R-HSA-202040	8.444232e-02	1.073
Basigin interactions	R-HSA-210991	8.444232e-02	1.073
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.544840e-02	1.068
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	8.615329e-02	1.065
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.839897e-02	1.054
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.095451e-02	1.041
Sema3A PAK dependent Axon repulsion	R-HSA-399954	9.100397e-02	1.041
G beta:gamma signalling through BTK	R-HSA-8964315	9.100397e-02	1.041
ERBB2 Regulates Cell Motility	R-HSA-6785631	9.100397e-02	1.041
Processive synthesis on the lagging strand	R-HSA-69183	9.100397e-02	1.041
Hemostasis	R-HSA-109582	9.178606e-02	1.037
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.210838e-02	1.036
Regulation of TP53 Degradation	R-HSA-6804757	9.210838e-02	1.036
G1/S-Specific Transcription	R-HSA-69205	9.210838e-02	1.036
PLC beta mediated events	R-HSA-112043	9.221056e-02	1.035
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.221056e-02	1.035
MAP kinase activation	R-HSA-450294	9.221056e-02	1.035
Sensory processing of sound	R-HSA-9659379	9.223627e-02	1.035
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	9.254877e-02	1.034
Lipophagy	R-HSA-9613354	9.254877e-02	1.034
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	9.254877e-02	1.034
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	9.254877e-02	1.034
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	9.255138e-02	1.034
Transport to the Golgi and subsequent modification	R-HSA-948021	9.421731e-02	1.026
Signaling by ERBB2 KD Mutants	R-HSA-9664565	9.475138e-02	1.023
Negative regulation of FGFR4 signaling	R-HSA-5654733	9.475138e-02	1.023
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	9.520088e-02	1.021
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	9.520088e-02	1.021
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.520088e-02	1.021
Signaling by PDGFR in disease	R-HSA-9671555	9.520088e-02	1.021
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.802331e-02	1.009
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	9.802331e-02	1.009
Regulation of PTEN stability and activity	R-HSA-8948751	9.802331e-02	1.009
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.806120e-02	1.009
Signaling by MET	R-HSA-6806834	9.806120e-02	1.009
Signaling by FGFR2	R-HSA-5654738	9.806120e-02	1.009
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.868893e-02	1.006
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.001715e-01	0.999
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.001715e-01	0.999
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.001715e-01	0.999
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.001715e-01	0.999
Degradation of DVL	R-HSA-4641258	1.006896e-01	0.997
Degradation of AXIN	R-HSA-4641257	1.006896e-01	0.997
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.006896e-01	0.997
Transmission across Chemical Synapses	R-HSA-112315	1.007372e-01	0.997
Fanconi Anemia Pathway	R-HSA-6783310	1.039225e-01	0.983
Defective CFTR causes cystic fibrosis	R-HSA-5678895	1.039225e-01	0.983
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.045734e-01	0.981
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.045773e-01	0.981
Regulation of NF-kappa B signaling	R-HSA-9758274	1.045773e-01	0.981
Regulation of BACH1 activity	R-HSA-9708530	1.045773e-01	0.981
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.051843e-01	0.978
Transcriptional regulation by RUNX3	R-HSA-8878159	1.063995e-01	0.973
FGFR2 alternative splicing	R-HSA-6803529	1.066199e-01	0.972
Notch-HLH transcription pathway	R-HSA-350054	1.066199e-01	0.972
mTORC1-mediated signalling	R-HSA-166208	1.066199e-01	0.972
Platelet homeostasis	R-HSA-418346	1.095320e-01	0.960
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.096911e-01	0.960
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.626335e-01	0.789
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	1.626335e-01	0.789
TICAM1 deficiency - HSE	R-HSA-5602566	1.626335e-01	0.789
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	R-HSA-5619043	1.626335e-01	0.789
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	1.626335e-01	0.789
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	1.626335e-01	0.789
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	1.626335e-01	0.789
IRS activation	R-HSA-74713	1.288991e-01	0.890
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	1.592388e-01	0.798
Noncanonical activation of NOTCH3	R-HSA-9017802	1.592388e-01	0.798
Binding and entry of HIV virion	R-HSA-173107	1.105454e-01	0.956
PI3K/AKT activation	R-HSA-198203	1.105454e-01	0.956
2-LTR circle formation	R-HSA-164843	1.105454e-01	0.956
PTK6 promotes HIF1A stabilization	R-HSA-8857538	1.907100e-01	0.720
Erythropoietin activates STAT5	R-HSA-9027283	1.907100e-01	0.720
Autointegration results in viral DNA circles	R-HSA-177539	1.907100e-01	0.720
G2/M DNA replication checkpoint	R-HSA-69478	1.907100e-01	0.720
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	1.907100e-01	0.720
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.297566e-01	0.887
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.297566e-01	0.887
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.297566e-01	0.887
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	1.500398e-01	0.824
Signaling by GSK3beta mutants	R-HSA-5339716	1.500398e-01	0.824
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.712515e-01	0.766
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.712515e-01	0.766
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.712515e-01	0.766
Scavenging by Class F Receptors	R-HSA-3000484	1.712515e-01	0.766
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.712515e-01	0.766
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.712515e-01	0.766
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.712515e-01	0.766
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.712515e-01	0.766
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.342486e-01	0.872
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.342486e-01	0.872
PI3K events in ERBB2 signaling	R-HSA-1963642	1.342486e-01	0.872
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	1.342486e-01	0.872
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.342486e-01	0.872
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.502323e-01	0.823
GAB1 signalosome	R-HSA-180292	1.502323e-01	0.823
G beta:gamma signalling through PLC beta	R-HSA-418217	1.502323e-01	0.823
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	1.313416e-01	0.882
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	2.158967e-01	0.666
Long-term potentiation	R-HSA-9620244	1.445870e-01	0.840
Formation of ATP by chemiosmotic coupling	R-HSA-163210	1.841833e-01	0.735
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.020189e-01	0.695
Interaction between L1 and Ankyrins	R-HSA-445095	1.726823e-01	0.763
Cristae formation	R-HSA-8949613	1.726823e-01	0.763
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.122165e-01	0.950
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.122165e-01	0.950
mRNA Splicing - Minor Pathway	R-HSA-72165	2.077984e-01	0.682
Signaling by NOTCH2	R-HSA-1980145	1.609635e-01	0.793
Rap1 signalling	R-HSA-392517	1.668989e-01	0.778
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.841833e-01	0.735
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	1.583790e-01	0.800
G beta:gamma signalling through CDC42	R-HSA-8964616	1.190105e-01	0.924
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.182810e-01	0.661
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.391287e-01	0.857
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.700781e-01	0.769
Regulation of mitotic cell cycle	R-HSA-453276	1.700781e-01	0.769
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	2.203249e-01	0.657
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	1.186758e-01	0.926
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	2.020189e-01	0.695
Resolution of Abasic Sites (AP sites)	R-HSA-73933	1.391287e-01	0.857
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.026726e-01	0.693
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.592388e-01	0.798
Reduction of cytosolic Ca++ levels	R-HSA-418359	1.500398e-01	0.824
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	1.583790e-01	0.800
Degradation of CRY and PER proteins	R-HSA-9932298	1.497151e-01	0.825
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	1.186758e-01	0.926
Nectin/Necl trans heterodimerization	R-HSA-420597	1.288991e-01	0.890
Platelet calcium homeostasis	R-HSA-418360	2.026726e-01	0.693
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	1.609243e-01	0.793
Sema4D in semaphorin signaling	R-HSA-400685	1.445870e-01	0.840
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.592388e-01	0.798
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	1.342486e-01	0.872
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.932499e-01	0.714
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	1.668989e-01	0.778
Deadenylation-dependent mRNA decay	R-HSA-429914	1.467683e-01	0.833
Mismatch Repair	R-HSA-5358508	1.502323e-01	0.823
Regulation of NFE2L2 gene expression	R-HSA-9818749	1.907100e-01	0.720
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.500398e-01	0.824
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	1.313416e-01	0.882
G-protein mediated events	R-HSA-112040	1.358655e-01	0.867
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	1.342486e-01	0.872
PIP3 activates AKT signaling	R-HSA-1257604	1.451562e-01	0.838
Cellular response to chemical stress	R-HSA-9711123	1.198150e-01	0.921
Polo-like kinase mediated events	R-HSA-156711	1.502323e-01	0.823
Response of endothelial cells to shear stress	R-HSA-9860931	1.501801e-01	0.823
EPH-Ephrin signaling	R-HSA-2682334	1.273201e-01	0.895
Bicarbonate transporters	R-HSA-425381	1.297566e-01	0.887
Signaling by APC mutants	R-HSA-4839744	1.297566e-01	0.887
Signaling by AXIN mutants	R-HSA-4839735	1.500398e-01	0.824
Signaling by AMER1 mutants	R-HSA-4839748	1.500398e-01	0.824
Regulation of FZD by ubiquitination	R-HSA-4641263	1.342486e-01	0.872
Presynaptic function of Kainate receptors	R-HSA-500657	1.502323e-01	0.823
Activation of kainate receptors upon glutamate binding	R-HSA-451326	1.874598e-01	0.727
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.609635e-01	0.793
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.609635e-01	0.793
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.497151e-01	0.825
Degradation of CDH1	R-HSA-9766229	1.391579e-01	0.856
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.903989e-01	0.720
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	1.749649e-01	0.757
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	2.203249e-01	0.657
Signaling by Hippo	R-HSA-2028269	1.342486e-01	0.872
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.370207e-01	0.863
Regulation of PTEN gene transcription	R-HSA-8943724	1.559005e-01	0.807
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.501801e-01	0.823
NOD1/2 Signaling Pathway	R-HSA-168638	1.609635e-01	0.793
Suppression of apoptosis	R-HSA-9635465	1.297566e-01	0.887
Malate-aspartate shuttle	R-HSA-9856872	2.158967e-01	0.666
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	1.191048e-01	0.924
Interleukin-1 family signaling	R-HSA-446652	1.855408e-01	0.732
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.487474e-01	0.828
Uptake and function of anthrax toxins	R-HSA-5210891	1.342486e-01	0.872
Cellular response to hypoxia	R-HSA-1234174	1.202577e-01	0.920
Gene expression (Transcription)	R-HSA-74160	2.118843e-01	0.674
Calnexin/calreticulin cycle	R-HSA-901042	1.609635e-01	0.793
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.583790e-01	0.800
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.210643e-01	0.917
Hedgehog 'on' state	R-HSA-5632684	1.700781e-01	0.769
Signaling by FGFR4	R-HSA-5654743	1.719670e-01	0.765
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.592388e-01	0.798
Integration of viral DNA into host genomic DNA	R-HSA-175567	1.907100e-01	0.720
Maturation of nucleoprotein	R-HSA-9683610	1.932499e-01	0.714
Syndecan interactions	R-HSA-3000170	1.186758e-01	0.926
Negative regulation of NOTCH4 signaling	R-HSA-9604323	1.289211e-01	0.890
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.391287e-01	0.857
Signaling by FGFR3	R-HSA-5654741	1.955508e-01	0.709
Interleukin-17 signaling	R-HSA-448424	1.611646e-01	0.793
Signaling by FGFR1	R-HSA-5654736	2.128491e-01	0.672
G1/S DNA Damage Checkpoints	R-HSA-69615	1.848793e-01	0.733
Signaling by FGFR	R-HSA-190236	1.777899e-01	0.750
Signal regulatory protein family interactions	R-HSA-391160	2.158967e-01	0.666
Insulin processing	R-HSA-264876	1.726823e-01	0.763
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.203249e-01	0.657
Maturation of nucleoprotein	R-HSA-9694631	1.668989e-01	0.778
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	1.836009e-01	0.736
Stabilization of p53	R-HSA-69541	1.191048e-01	0.924
Ion channel transport	R-HSA-983712	1.209984e-01	0.917
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.191048e-01	0.924
Sodium-coupled phosphate cotransporters	R-HSA-427652	1.592388e-01	0.798
Plasma lipoprotein clearance	R-HSA-8964043	1.191048e-01	0.924
Glucagon-type ligand receptors	R-HSA-420092	2.026726e-01	0.693
Cyclin E associated events during G1/S transition	R-HSA-69202	1.611646e-01	0.793
Signaling by ERBB4	R-HSA-1236394	1.981620e-01	0.703
Regulation of TP53 Activity	R-HSA-5633007	1.194730e-01	0.923
Zinc transporters	R-HSA-435354	2.158967e-01	0.666
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.313416e-01	0.882
Neurodegenerative Diseases	R-HSA-8863678	1.313416e-01	0.882
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	1.391287e-01	0.857
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	1.955508e-01	0.709
Stimuli-sensing channels	R-HSA-2672351	1.208347e-01	0.918
Growth hormone receptor signaling	R-HSA-982772	1.186758e-01	0.926
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.726823e-01	0.763
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.288991e-01	0.890
SLC-mediated transport of inorganic anions	R-HSA-9958790	2.136119e-01	0.670
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.502323e-01	0.823
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.020189e-01	0.695
Uptake and actions of bacterial toxins	R-HSA-5339562	1.690147e-01	0.772
Signaling by Leptin	R-HSA-2586552	1.105454e-01	0.956
Inositol phosphate metabolism	R-HSA-1483249	2.183548e-01	0.661
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	2.020189e-01	0.695
XBP1(S) activates chaperone genes	R-HSA-381038	1.448278e-01	0.839
IRE1alpha activates chaperones	R-HSA-381070	1.927860e-01	0.715
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.020189e-01	0.695
Unfolded Protein Response (UPR)	R-HSA-381119	1.607820e-01	0.794
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.502323e-01	0.823
MECP2 regulates transcription factors	R-HSA-9022707	2.229022e-01	0.652
TRIF-mediated programmed cell death	R-HSA-2562578	2.229022e-01	0.652
SOS-mediated signalling	R-HSA-112412	2.229022e-01	0.652
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.229022e-01	0.652
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.229022e-01	0.652
RUNX3 regulates WNT signaling	R-HSA-8951430	2.229022e-01	0.652
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.229022e-01	0.652
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.229022e-01	0.652
RAS processing	R-HSA-9648002	2.276193e-01	0.643
Translation of Structural Proteins	R-HSA-9694635	2.280891e-01	0.642
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	R-HSA-73930	2.337513e-01	0.631
TRAF3 deficiency - HSE	R-HSA-5602571	2.337513e-01	0.631
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.337513e-01	0.631
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	2.337513e-01	0.631
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.337513e-01	0.631
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.337513e-01	0.631
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	2.337513e-01	0.631
Nef mediated downregulation of CD28 cell surface expression	R-HSA-164939	2.337513e-01	0.631
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.337513e-01	0.631
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.342444e-01	0.630
Cellular responses to mechanical stimuli	R-HSA-9855142	2.350910e-01	0.629
Pyruvate metabolism	R-HSA-70268	2.382651e-01	0.623
Erythropoietin activates RAS	R-HSA-9027284	2.390589e-01	0.621
Beta-catenin phosphorylation cascade	R-HSA-196299	2.390589e-01	0.621
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.390589e-01	0.621
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	2.390743e-01	0.621
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.390743e-01	0.621
Glycogen metabolism	R-HSA-8982491	2.419108e-01	0.616
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	2.461354e-01	0.609
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.461354e-01	0.609
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.461354e-01	0.609
CLEC7A (Dectin-1) signaling	R-HSA-5607764	2.469747e-01	0.607
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.490634e-01	0.604
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	2.505218e-01	0.601
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.523235e-01	0.598
Metabolism of proteins	R-HSA-392499	2.547605e-01	0.594
RSK activation	R-HSA-444257	2.554663e-01	0.593
Signaling by MRAS-complex mutants	R-HSA-9660537	2.554663e-01	0.593
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.554663e-01	0.593
Axonal growth inhibition (RHOA activation)	R-HSA-193634	2.554663e-01	0.593
FLT3 Signaling	R-HSA-9607240	2.564584e-01	0.591
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.581604e-01	0.588
ER-Phagosome pathway	R-HSA-1236974	2.582518e-01	0.588
Neuronal System	R-HSA-112316	2.586795e-01	0.587
MITF-M-regulated melanocyte development	R-HSA-9730414	2.586908e-01	0.587
Prolonged ERK activation events	R-HSA-169893	2.626098e-01	0.581
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.626098e-01	0.581
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.661889e-01	0.575
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.661889e-01	0.575
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.661889e-01	0.575
G-protein beta:gamma signalling	R-HSA-397795	2.670723e-01	0.573
Nuclear RNA decay	R-HSA-9930044	2.670723e-01	0.573
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.670723e-01	0.573
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.670723e-01	0.573
Downstream TCR signaling	R-HSA-202424	2.684538e-01	0.571
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	2.712337e-01	0.567
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	2.728201e-01	0.564
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	2.730381e-01	0.564
Thromboxane signalling through TP receptor	R-HSA-428930	2.775313e-01	0.557
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.775313e-01	0.557
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.824623e-01	0.549
Cytosolic tRNA aminoacylation	R-HSA-379716	2.862085e-01	0.543
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.864301e-01	0.543
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	2.864301e-01	0.543
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.864301e-01	0.543
Neurexins and neuroligins	R-HSA-6794361	2.864381e-01	0.543
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	2.864381e-01	0.543
ARMS-mediated activation	R-HSA-170984	2.881072e-01	0.540
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	2.881072e-01	0.540
Calcineurin activates NFAT	R-HSA-2025928	2.881072e-01	0.540
p75NTR regulates axonogenesis	R-HSA-193697	2.881072e-01	0.540
GP1b-IX-V activation signalling	R-HSA-430116	2.881072e-01	0.540
Butyrophilin (BTN) family interactions	R-HSA-8851680	2.881072e-01	0.540
Respiratory syncytial virus genome replication	R-HSA-9834752	2.881072e-01	0.540
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	2.971235e-01	0.527
Activation of G protein gated Potassium channels	R-HSA-1296041	2.971235e-01	0.527
G protein gated Potassium channels	R-HSA-1296059	2.971235e-01	0.527
TGFBR3 expression	R-HSA-9839394	2.971235e-01	0.527
Tight junction interactions	R-HSA-420029	2.971235e-01	0.527
VEGFR2 mediated cell proliferation	R-HSA-5218921	2.971235e-01	0.527
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	2.988329e-01	0.525
Defective ALG9 causes CDG-1l	R-HSA-4720454	2.988329e-01	0.525
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	2.988329e-01	0.525
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	2.988329e-01	0.525
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	2.988329e-01	0.525
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	2.988329e-01	0.525
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	2.988329e-01	0.525
Signalling to ERK5	R-HSA-198765	2.988329e-01	0.525
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	2.988329e-01	0.525
Interleukin-33 signaling	R-HSA-9014843	2.988329e-01	0.525
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	2.988329e-01	0.525
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	2.988329e-01	0.525
Signal amplification	R-HSA-392518	3.008291e-01	0.522
Signaling by SCF-KIT	R-HSA-1433557	3.013545e-01	0.521
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	3.048143e-01	0.516
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.073923e-01	0.512
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	3.109396e-01	0.507
Ion transport by P-type ATPases	R-HSA-936837	3.109396e-01	0.507
Amine ligand-binding receptors	R-HSA-375280	3.166433e-01	0.499
EPHB-mediated forward signaling	R-HSA-3928662	3.166433e-01	0.499
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.168755e-01	0.499
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.168755e-01	0.499
Suppression of phagosomal maturation	R-HSA-9637687	3.168755e-01	0.499
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.205772e-01	0.494
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.205772e-01	0.494
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.205772e-01	0.494
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	3.205772e-01	0.494
EGFR Transactivation by Gastrin	R-HSA-2179392	3.205772e-01	0.494
Signal attenuation	R-HSA-74749	3.205772e-01	0.494
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.205772e-01	0.494
Toll-like Receptor Cascades	R-HSA-168898	3.208633e-01	0.494
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	3.210925e-01	0.493
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	3.263228e-01	0.486
G alpha (z) signalling events	R-HSA-418597	3.281419e-01	0.484
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	3.320210e-01	0.479
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.344405e-01	0.476
RET signaling	R-HSA-8853659	3.351946e-01	0.475
Processive synthesis on the C-strand of the telomere	R-HSA-174414	3.367284e-01	0.473
EPHA-mediated growth cone collapse	R-HSA-3928663	3.367284e-01	0.473
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.367284e-01	0.473
ER Quality Control Compartment (ERQC)	R-HSA-901032	3.367284e-01	0.473
RSV-host interactions	R-HSA-9833110	3.368048e-01	0.473
NRAGE signals death through JNK	R-HSA-193648	3.422563e-01	0.466
Signaling by TGFBR3	R-HSA-9839373	3.475392e-01	0.459
Regulation of pyruvate metabolism	R-HSA-9861718	3.475392e-01	0.459
RHOBTB3 ATPase cycle	R-HSA-9706019	3.526700e-01	0.453
LGI-ADAM interactions	R-HSA-5682910	3.526700e-01	0.453
CD163 mediating an anti-inflammatory response	R-HSA-9662834	3.526700e-01	0.453
ChREBP activates metabolic gene expression	R-HSA-163765	3.526700e-01	0.453
ABC transporter disorders	R-HSA-5619084	3.560606e-01	0.448
Phase 0 - rapid depolarisation	R-HSA-5576892	3.566260e-01	0.448
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.583903e-01	0.446
MET activates PTPN11	R-HSA-8865999	3.583903e-01	0.446
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.583903e-01	0.446
Defective ABCC2 causes DJS	R-HSA-5679001	3.583903e-01	0.446
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.583903e-01	0.446
MET interacts with TNS proteins	R-HSA-8875513	3.583903e-01	0.446
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.583903e-01	0.446
Histamine receptors	R-HSA-390650	3.583903e-01	0.446
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.584321e-01	0.446
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.584321e-01	0.446
Regulated Necrosis	R-HSA-5218859	3.631614e-01	0.440
MET promotes cell motility	R-HSA-8875878	3.698630e-01	0.432
Signaling by Erythropoietin	R-HSA-9006335	3.765149e-01	0.424
mRNA Capping	R-HSA-72086	3.765149e-01	0.424
Co-stimulation by CD28	R-HSA-389356	3.786798e-01	0.422
Antigen processing-Cross presentation	R-HSA-1236975	3.787479e-01	0.422
Co-inhibition by CTLA4	R-HSA-389513	3.822963e-01	0.418
Signal transduction by L1	R-HSA-445144	3.822963e-01	0.418
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	3.822963e-01	0.418
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.842156e-01	0.415
Sensing of DNA Double Strand Breaks	R-HSA-5693548	3.842156e-01	0.415
Mitotic Telophase/Cytokinesis	R-HSA-68884	3.842156e-01	0.415
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	3.842156e-01	0.415
Activation of RAC1	R-HSA-428540	3.842156e-01	0.415
Integration of energy metabolism	R-HSA-163685	3.846559e-01	0.415
Extension of Telomeres	R-HSA-180786	3.849516e-01	0.415
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.872203e-01	0.412
Pentose phosphate pathway	R-HSA-71336	3.872203e-01	0.412
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	3.872203e-01	0.412
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.963452e-01	0.402
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	3.963452e-01	0.402
Interleukin-37 signaling	R-HSA-9008059	3.963452e-01	0.402
ABC-family proteins mediated transport	R-HSA-382556	3.981700e-01	0.400
tRNA Aminoacylation	R-HSA-379724	3.992345e-01	0.399
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	4.013746e-01	0.396
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	4.013746e-01	0.396
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	4.028628e-01	0.395
Generation of second messenger molecules	R-HSA-202433	4.045479e-01	0.393
Interferon gamma signaling	R-HSA-877300	4.048510e-01	0.393
Transcriptional Regulation by TP53	R-HSA-3700989	4.070360e-01	0.390
HCN channels	R-HSA-1296061	4.128921e-01	0.384
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.128921e-01	0.384
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.128921e-01	0.384
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.128921e-01	0.384
Defective LFNG causes SCDO3	R-HSA-5083630	4.128921e-01	0.384
Regulation of gap junction activity	R-HSA-191650	4.128921e-01	0.384
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	4.128921e-01	0.384
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.128921e-01	0.384
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.128921e-01	0.384
TNFR1-mediated ceramide production	R-HSA-5626978	4.128921e-01	0.384
NADE modulates death signalling	R-HSA-205025	4.128921e-01	0.384
Dopamine receptors	R-HSA-390651	4.128921e-01	0.384
Repression of WNT target genes	R-HSA-4641265	4.150755e-01	0.382
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	4.150755e-01	0.382
Regulation of IFNG signaling	R-HSA-877312	4.150755e-01	0.382
Signaling by LTK	R-HSA-9842663	4.150755e-01	0.382
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.150755e-01	0.382
Trafficking of AMPA receptors	R-HSA-399719	4.160696e-01	0.381
Late SARS-CoV-2 Infection Events	R-HSA-9772573	4.194119e-01	0.377
Disorders of transmembrane transporters	R-HSA-5619115	4.209652e-01	0.376
Potential therapeutics for SARS	R-HSA-9679191	4.224909e-01	0.374
MITF-M-dependent gene expression	R-HSA-9856651	4.224909e-01	0.374
Ribavirin ADME	R-HSA-9755088	4.293361e-01	0.367
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.319363e-01	0.365
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.319363e-01	0.365
Inwardly rectifying K+ channels	R-HSA-1296065	4.356447e-01	0.361
Signaling by FGFR1 in disease	R-HSA-5655302	4.389871e-01	0.358
Formation of RNA Pol II elongation complex	R-HSA-112382	4.408860e-01	0.356
Circadian clock	R-HSA-9909396	4.417184e-01	0.355
Protein-protein interactions at synapses	R-HSA-6794362	4.428142e-01	0.354
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	4.451388e-01	0.352
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.451388e-01	0.352
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	4.451388e-01	0.352
Frs2-mediated activation	R-HSA-170968	4.451388e-01	0.352
Integrin signaling	R-HSA-354192	4.550300e-01	0.342
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	4.550300e-01	0.342
FGFR1 mutant receptor activation	R-HSA-1839124	4.550300e-01	0.342
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	4.550300e-01	0.342
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	4.550300e-01	0.342
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	4.550300e-01	0.342
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.560397e-01	0.341
RNA Polymerase II Transcription Elongation	R-HSA-75955	4.562859e-01	0.341
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	4.627671e-01	0.335
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	4.627671e-01	0.335
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.627671e-01	0.335
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	4.627671e-01	0.335
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	4.627671e-01	0.335
Post-transcriptional silencing by small RNAs	R-HSA-426496	4.627671e-01	0.335
Reelin signalling pathway	R-HSA-8866376	4.627671e-01	0.335
Muscarinic acetylcholine receptors	R-HSA-390648	4.627671e-01	0.335
Interleukin-36 pathway	R-HSA-9014826	4.627671e-01	0.335
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.627671e-01	0.335
Pyrophosphate hydrolysis	R-HSA-71737	4.627671e-01	0.335
Co-inhibition by BTLA	R-HSA-9927353	4.627671e-01	0.335
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.627671e-01	0.335
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	4.627671e-01	0.335
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.627671e-01	0.335
Assembly of Viral Components at the Budding Site	R-HSA-168316	4.627671e-01	0.335
Resolution of D-Loop Structures	R-HSA-5693537	4.741883e-01	0.324
Glucagon signaling in metabolic regulation	R-HSA-163359	4.741883e-01	0.324
Interferon alpha/beta signaling	R-HSA-909733	4.742233e-01	0.324
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	4.743180e-01	0.324
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	4.743180e-01	0.324
Retrograde neurotrophin signalling	R-HSA-177504	4.743180e-01	0.324
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	4.743180e-01	0.324
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	4.750270e-01	0.323
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	4.750270e-01	0.323
RNA Polymerase II Transcription	R-HSA-73857	4.849533e-01	0.314
Cyclin D associated events in G1	R-HSA-69231	4.896768e-01	0.310
G1 Phase	R-HSA-69236	4.896768e-01	0.310
eNOS activation	R-HSA-203615	4.930859e-01	0.307
NPAS4 regulates expression of target genes	R-HSA-9768919	4.930859e-01	0.307
Mitochondrial biogenesis	R-HSA-1592230	4.952287e-01	0.305
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	4.972328e-01	0.303
Regulation of insulin secretion	R-HSA-422356	5.008187e-01	0.300
Telomere C-strand synthesis initiation	R-HSA-174430	5.025466e-01	0.299
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.025466e-01	0.299
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	5.025466e-01	0.299
Signaling by NTRK1 (TRKA)	R-HSA-187037	5.027890e-01	0.299
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	5.062128e-01	0.296
Signaling by NTRKs	R-HSA-166520	5.069624e-01	0.295
Plus-strand DNA synthesis	R-HSA-164525	5.084080e-01	0.294
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.084080e-01	0.294
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.084080e-01	0.294
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.084080e-01	0.294
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.084080e-01	0.294
Pentose phosphate pathway disease	R-HSA-6791465	5.084080e-01	0.294
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.084080e-01	0.294
Cam-PDE 1 activation	R-HSA-111957	5.084080e-01	0.294
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.084080e-01	0.294
CDC6 association with the ORC:origin complex	R-HSA-68689	5.084080e-01	0.294
Intestinal hexose absorption	R-HSA-8981373	5.084080e-01	0.294
Signalling to p38 via RIT and RIN	R-HSA-187706	5.084080e-01	0.294
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.084080e-01	0.294
Regulation of CDH19 Expression and Function	R-HSA-9764302	5.084080e-01	0.294
tRNA processing	R-HSA-72306	5.106249e-01	0.292
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	5.116922e-01	0.291
Transcription of the HIV genome	R-HSA-167172	5.118138e-01	0.291
C-type lectin receptors (CLRs)	R-HSA-5621481	5.193055e-01	0.285
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	5.225313e-01	0.282
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.297755e-01	0.276
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	5.297755e-01	0.276
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.297755e-01	0.276
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.297755e-01	0.276
GPVI-mediated activation cascade	R-HSA-114604	5.299795e-01	0.276
Extra-nuclear estrogen signaling	R-HSA-9009391	5.348305e-01	0.272
TRP channels	R-HSA-3295583	5.401571e-01	0.267
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	5.401571e-01	0.267
Cardiac conduction	R-HSA-5576891	5.423548e-01	0.266
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.501740e-01	0.259
Signaling by LTK in cancer	R-HSA-9842640	5.501740e-01	0.259
Uncoating of the HIV Virion	R-HSA-162585	5.501740e-01	0.259
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.501740e-01	0.259
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.501740e-01	0.259
Lactose synthesis	R-HSA-5653890	5.501740e-01	0.259
CREB phosphorylation	R-HSA-199920	5.501740e-01	0.259
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	5.501740e-01	0.259
Leukotriene receptors	R-HSA-391906	5.501740e-01	0.259
HDL clearance	R-HSA-8964011	5.501740e-01	0.259
VLDL assembly	R-HSA-8866423	5.501740e-01	0.259
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.559708e-01	0.255
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.559708e-01	0.255
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.559708e-01	0.255
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.559708e-01	0.255
TRAF3-dependent IRF activation pathway	R-HSA-918233	5.559708e-01	0.255
Acetylcholine regulates insulin secretion	R-HSA-399997	5.559708e-01	0.255
Coenzyme A biosynthesis	R-HSA-196783	5.559708e-01	0.255
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	5.655027e-01	0.248
SLC transporter disorders	R-HSA-5619102	5.748271e-01	0.240
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.808922e-01	0.236
Formation of the Early Elongation Complex	R-HSA-113418	5.808922e-01	0.236
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	5.811116e-01	0.236
Elevation of cytosolic Ca2+ levels	R-HSA-139853	5.811116e-01	0.236
Specification of primordial germ cells	R-HSA-9827857	5.811116e-01	0.236
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	5.826981e-01	0.235
Signaling by ALK	R-HSA-201556	5.826981e-01	0.235
Heme signaling	R-HSA-9707616	5.881346e-01	0.231
MET activates PI3K/AKT signaling	R-HSA-8851907	5.883937e-01	0.230
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	5.883937e-01	0.230
NOSTRIN mediated eNOS trafficking	R-HSA-203641	5.883937e-01	0.230
IFNG signaling activates MAPKs	R-HSA-9732724	5.883937e-01	0.230
Recycling of eIF2:GDP	R-HSA-72731	5.883937e-01	0.230
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	5.883937e-01	0.230
Disinhibition of SNARE formation	R-HSA-114516	5.883937e-01	0.230
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	5.883937e-01	0.230
Cohesin Loading onto Chromatin	R-HSA-2470946	5.883937e-01	0.230
PTK6 Expression	R-HSA-8849473	5.883937e-01	0.230
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	5.883937e-01	0.230
Nef Mediated CD4 Down-regulation	R-HSA-167590	5.883937e-01	0.230
Activated NTRK2 signals through CDK5	R-HSA-9032845	5.883937e-01	0.230
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	5.883937e-01	0.230
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.883937e-01	0.230
LDL remodeling	R-HSA-8964041	5.883937e-01	0.230
VLDL clearance	R-HSA-8964046	5.883937e-01	0.230
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	5.883937e-01	0.230
Cation-coupled Chloride cotransporters	R-HSA-426117	5.883937e-01	0.230
CHL1 interactions	R-HSA-447041	5.883937e-01	0.230
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	5.883937e-01	0.230
Signaling by FGFR in disease	R-HSA-1226099	5.911289e-01	0.228
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	5.994939e-01	0.222
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	5.994939e-01	0.222
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	5.994939e-01	0.222
Nuclear signaling by ERBB4	R-HSA-1251985	5.994939e-01	0.222
The phototransduction cascade	R-HSA-2514856	6.002305e-01	0.222
Regulation of CDH11 Expression and Function	R-HSA-9759475	6.003818e-01	0.222
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.003818e-01	0.222
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.051879e-01	0.218
Ephrin signaling	R-HSA-3928664	6.051879e-01	0.218
PKA activation	R-HSA-163615	6.051879e-01	0.218
Rab regulation of trafficking	R-HSA-9007101	6.130189e-01	0.213
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.148894e-01	0.211
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	6.158763e-01	0.211
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	6.192653e-01	0.208
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	6.192653e-01	0.208
Reverse Transcription of HIV RNA	R-HSA-162589	6.233681e-01	0.205
Minus-strand DNA synthesis	R-HSA-164516	6.233681e-01	0.205
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.233681e-01	0.205
phospho-PLA2 pathway	R-HSA-111995	6.233681e-01	0.205
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.233681e-01	0.205
MET receptor recycling	R-HSA-8875656	6.233681e-01	0.205
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.233681e-01	0.205
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.233681e-01	0.205
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.233681e-01	0.205
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.233681e-01	0.205
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	6.233681e-01	0.205
Regulation by c-FLIP	R-HSA-3371378	6.233681e-01	0.205
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	6.233681e-01	0.205
ROBO receptors bind AKAP5	R-HSA-9010642	6.233681e-01	0.205
TGFBR3 PTM regulation	R-HSA-9839383	6.233681e-01	0.205
Dimerization of procaspase-8	R-HSA-69416	6.233681e-01	0.205
Intestinal absorption	R-HSA-8963676	6.233681e-01	0.205
Interleukin-23 signaling	R-HSA-9020933	6.233681e-01	0.205
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.281993e-01	0.202
E2F mediated regulation of DNA replication	R-HSA-113510	6.281993e-01	0.202
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.281993e-01	0.202
The NLRP3 inflammasome	R-HSA-844456	6.281993e-01	0.202
Amino acids regulate mTORC1	R-HSA-9639288	6.292280e-01	0.201
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	6.318343e-01	0.199
HIV Transcription Initiation	R-HSA-167161	6.318343e-01	0.199
RNA Polymerase II Transcription Initiation	R-HSA-75953	6.318343e-01	0.199
Molecules associated with elastic fibres	R-HSA-2129379	6.375324e-01	0.195
Generic Transcription Pathway	R-HSA-212436	6.383307e-01	0.195
Activation of GABAB receptors	R-HSA-991365	6.473590e-01	0.189
GABA B receptor activation	R-HSA-977444	6.473590e-01	0.189
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.501527e-01	0.187
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.501527e-01	0.187
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.501527e-01	0.187
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.501527e-01	0.187
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.501527e-01	0.187
VxPx cargo-targeting to cilium	R-HSA-5620916	6.501527e-01	0.187
Creatine metabolism	R-HSA-71288	6.501527e-01	0.187
Formation of definitive endoderm	R-HSA-9823730	6.501527e-01	0.187
Diseases of mitotic cell cycle	R-HSA-9675126	6.551766e-01	0.184
Signaling by WNT in cancer	R-HSA-4791275	6.551766e-01	0.184
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	6.551766e-01	0.184
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	6.551766e-01	0.184
CASP8 activity is inhibited	R-HSA-5218900	6.553727e-01	0.184
ALK mutants bind TKIs	R-HSA-9700645	6.553727e-01	0.184
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.553727e-01	0.184
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.553727e-01	0.184
Inactivation of CDC42 and RAC1	R-HSA-428543	6.553727e-01	0.184
MASTL Facilitates Mitotic Progression	R-HSA-2465910	6.553727e-01	0.184
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.553727e-01	0.184
Regulation of signaling by NODAL	R-HSA-1433617	6.553727e-01	0.184
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	6.553727e-01	0.184
Regulation of CDH11 gene transcription	R-HSA-9762293	6.553727e-01	0.184
Regulated proteolysis of p75NTR	R-HSA-193692	6.553727e-01	0.184
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.553727e-01	0.184
Cellular response to mitochondrial stress	R-HSA-9840373	6.553727e-01	0.184
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.553727e-01	0.184
RNA Polymerase II Promoter Escape	R-HSA-73776	6.624435e-01	0.179
TBC/RABGAPs	R-HSA-8854214	6.624435e-01	0.179
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	6.700090e-01	0.174
MyD88 deficiency (TLR2/4)	R-HSA-5602498	6.710618e-01	0.173
ERK/MAPK targets	R-HSA-198753	6.710618e-01	0.173
PKA-mediated phosphorylation of CREB	R-HSA-111931	6.710618e-01	0.173
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.721949e-01	0.173
Proteasome assembly	R-HSA-9907900	6.770830e-01	0.169
Netrin-1 signaling	R-HSA-373752	6.770830e-01	0.169
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.828670e-01	0.166
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	6.832323e-01	0.165
DNA replication initiation	R-HSA-68952	6.846594e-01	0.165
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	6.846594e-01	0.165
Regulation of CDH11 function	R-HSA-9762292	6.846594e-01	0.165
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	6.846594e-01	0.165
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	6.846594e-01	0.165
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	6.846594e-01	0.165
CASP4 inflammasome assembly	R-HSA-9948001	6.846594e-01	0.165
Maturation of spike protein	R-HSA-9683686	6.846594e-01	0.165
Tandem pore domain potassium channels	R-HSA-1296346	6.846594e-01	0.165
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	6.846594e-01	0.165
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.876698e-01	0.163
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	6.885871e-01	0.162
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	6.885871e-01	0.162
Effects of PIP2 hydrolysis	R-HSA-114508	6.885871e-01	0.162
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	6.909455e-01	0.161
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	6.909455e-01	0.161
Mitochondrial calcium ion transport	R-HSA-8949215	6.909455e-01	0.161
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	6.909455e-01	0.161
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	6.912745e-01	0.160
Platelet Aggregation (Plug Formation)	R-HSA-76009	6.912745e-01	0.160
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	6.912745e-01	0.160
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	6.930608e-01	0.159
Cytoprotection by HMOX1	R-HSA-9707564	6.964589e-01	0.157
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	6.964589e-01	0.157
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.043560e-01	0.152
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.098271e-01	0.149
LDL clearance	R-HSA-8964038	7.098271e-01	0.149
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	7.098271e-01	0.149
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.098271e-01	0.149
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.114589e-01	0.148
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.114589e-01	0.148
Ionotropic activity of kainate receptors	R-HSA-451306	7.114589e-01	0.148
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	7.114589e-01	0.148
vRNP Assembly	R-HSA-192905	7.114589e-01	0.148
Chylomicron assembly	R-HSA-8963888	7.114589e-01	0.148
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.114589e-01	0.148
Transport of RCbl within the body	R-HSA-9758890	7.114589e-01	0.148
Interleukin-2 signaling	R-HSA-9020558	7.114589e-01	0.148
Dissolution of Fibrin Clot	R-HSA-75205	7.114589e-01	0.148
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	7.195067e-01	0.143
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	7.195067e-01	0.143
Signalling to ERKs	R-HSA-187687	7.195067e-01	0.143
Diseases of carbohydrate metabolism	R-HSA-5663084	7.233267e-01	0.141
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.273195e-01	0.138
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	7.277333e-01	0.138
Neddylation	R-HSA-8951664	7.281985e-01	0.138
GPER1 signaling	R-HSA-9634597	7.311552e-01	0.136
Metal ion SLC transporters	R-HSA-425410	7.311552e-01	0.136
Aquaporin-mediated transport	R-HSA-445717	7.316737e-01	0.136
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.327603e-01	0.135
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.359822e-01	0.133
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.359822e-01	0.133
ERKs are inactivated	R-HSA-202670	7.359822e-01	0.133
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.359822e-01	0.133
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.359822e-01	0.133
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.359822e-01	0.133
Sodium/Calcium exchangers	R-HSA-425561	7.359822e-01	0.133
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.359822e-01	0.133
Negative regulation of the PI3K/AKT network	R-HSA-199418	7.379124e-01	0.132
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	7.407881e-01	0.130
Transcriptional regulation by RUNX2	R-HSA-8878166	7.410008e-01	0.130
Mitochondrial protein import	R-HSA-1268020	7.429040e-01	0.129
Iron uptake and transport	R-HSA-917937	7.442231e-01	0.128
TRAF6 mediated IRF7 activation	R-HSA-933541	7.479845e-01	0.126
Adipogenesis	R-HSA-9843745	7.533453e-01	0.123
Azathioprine ADME	R-HSA-9748787	7.555165e-01	0.122
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.584226e-01	0.120
RUNX3 regulates p14-ARF	R-HSA-8951936	7.584226e-01	0.120
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	7.584226e-01	0.120
RUNX3 regulates NOTCH signaling	R-HSA-8941856	7.584226e-01	0.120
GRB2 events in EGFR signaling	R-HSA-179812	7.584226e-01	0.120
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.584226e-01	0.120
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.584226e-01	0.120
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.584226e-01	0.120
MET activates RAS signaling	R-HSA-8851805	7.584226e-01	0.120
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	7.584226e-01	0.120
OAS antiviral response	R-HSA-8983711	7.584226e-01	0.120
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	7.607387e-01	0.119
Acyl chain remodelling of PS	R-HSA-1482801	7.607387e-01	0.119
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.607387e-01	0.119
SWI/SNF chromatin remodelers	R-HSA-9932451	7.607387e-01	0.119
ATP-dependent chromatin remodelers	R-HSA-9932444	7.607387e-01	0.119
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.607387e-01	0.119
Formation of the nephric duct	R-HSA-9830364	7.607387e-01	0.119
Interleukin-7 signaling	R-HSA-1266695	7.607387e-01	0.119
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	7.613314e-01	0.118
Elastic fibre formation	R-HSA-1566948	7.613314e-01	0.118
Post-translational protein modification	R-HSA-597592	7.696968e-01	0.114
Integrin cell surface interactions	R-HSA-216083	7.733946e-01	0.112
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	7.740993e-01	0.111
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	7.759024e-01	0.110
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.759024e-01	0.110
Asparagine N-linked glycosylation	R-HSA-446203	7.788878e-01	0.109
Microbial factors inhibit CASP4 activity	R-HSA-9956593	7.789569e-01	0.108
Formation of axial mesoderm	R-HSA-9796292	7.789569e-01	0.108
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	7.789569e-01	0.108
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	7.789569e-01	0.108
Platelet Adhesion to exposed collagen	R-HSA-75892	7.789569e-01	0.108
Reversible hydration of carbon dioxide	R-HSA-1475029	7.789569e-01	0.108
CD28 dependent Vav1 pathway	R-HSA-389359	7.789569e-01	0.108
Interleukin-6 signaling	R-HSA-1059683	7.789569e-01	0.108
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.863014e-01	0.104
HIV Transcription Elongation	R-HSA-167169	7.863014e-01	0.104
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	7.863014e-01	0.104
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.863014e-01	0.104
Diseases of Immune System	R-HSA-5260271	7.863014e-01	0.104
Golgi Associated Vesicle Biogenesis	R-HSA-432722	7.888102e-01	0.103
Nucleotide biosynthesis	R-HSA-8956320	7.888102e-01	0.103
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	7.902184e-01	0.102
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	7.902184e-01	0.102
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	7.902184e-01	0.102
Signaling by NTRK2 (TRKB)	R-HSA-9006115	7.902184e-01	0.102
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.902184e-01	0.102
Maturation of hRSV A proteins	R-HSA-9828806	7.902184e-01	0.102
CRMPs in Sema3A signaling	R-HSA-399956	7.977469e-01	0.098
Hydrolysis of LPC	R-HSA-1483115	7.977469e-01	0.098
Signaling by FGFR4 in disease	R-HSA-5655291	7.977469e-01	0.098
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	7.977469e-01	0.098
Physiological factors	R-HSA-5578768	7.977469e-01	0.098
Prolactin receptor signaling	R-HSA-1170546	7.977469e-01	0.098
Respiratory syncytial virus genome transcription	R-HSA-9828642	7.977469e-01	0.098
Non-canonical inflammasome activation	R-HSA-9686114	7.977469e-01	0.098
Acyl chain remodeling of CL	R-HSA-1482798	7.977469e-01	0.098
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.994039e-01	0.097
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.000014e-01	0.097
Telomere Extension By Telomerase	R-HSA-171319	8.037210e-01	0.095
HIV elongation arrest and recovery	R-HSA-167287	8.037210e-01	0.095
Pausing and recovery of HIV elongation	R-HSA-167290	8.037210e-01	0.095
Insulin receptor recycling	R-HSA-77387	8.037210e-01	0.095
Inflammasomes	R-HSA-622312	8.037210e-01	0.095
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.089571e-01	0.092
Intra-Golgi traffic	R-HSA-6811438	8.090659e-01	0.092
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.090659e-01	0.092
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.149407e-01	0.089
SHC1 events in EGFR signaling	R-HSA-180336	8.149407e-01	0.089
Protein lipoylation	R-HSA-9857492	8.149407e-01	0.089
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.149407e-01	0.089
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.149407e-01	0.089
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	8.149407e-01	0.089
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	8.149407e-01	0.089
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	8.149407e-01	0.089
DCC mediated attractive signaling	R-HSA-418885	8.149407e-01	0.089
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.164451e-01	0.088
DARPP-32 events	R-HSA-180024	8.164451e-01	0.088
Regulation of gene expression in beta cells	R-HSA-210745	8.164451e-01	0.088
RNA Polymerase I Transcription Initiation	R-HSA-73762	8.196590e-01	0.086
COPII-mediated vesicle transport	R-HSA-204005	8.204243e-01	0.086
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.284255e-01	0.082
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.284255e-01	0.082
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.292474e-01	0.081
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	8.306737e-01	0.081
Phosphorylation of the APC/C	R-HSA-176412	8.306737e-01	0.081
Defective GALNT3 causes HFTC	R-HSA-5083625	8.306737e-01	0.081
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.306737e-01	0.081
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	8.306737e-01	0.081
Activation of SMO	R-HSA-5635838	8.306737e-01	0.081
Phase 4 - resting membrane potential	R-HSA-5576886	8.306737e-01	0.081
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.306737e-01	0.081
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.306737e-01	0.081
Attachment and Entry	R-HSA-9678110	8.306737e-01	0.081
Atorvastatin ADME	R-HSA-9754706	8.306737e-01	0.081
Virus Assembly and Release	R-HSA-168268	8.306737e-01	0.081
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.355833e-01	0.078
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.361260e-01	0.078
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.396965e-01	0.076
Cargo concentration in the ER	R-HSA-5694530	8.396965e-01	0.076
Peroxisomal protein import	R-HSA-9033241	8.444436e-01	0.073
Infection with Mycobacterium tuberculosis	R-HSA-9635486	8.447655e-01	0.073
Phase 2 - plateau phase	R-HSA-5576893	8.450700e-01	0.073
Glycine degradation	R-HSA-6783984	8.450700e-01	0.073
Passive transport by Aquaporins	R-HSA-432047	8.450700e-01	0.073
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	8.450700e-01	0.073
tRNA modification in the mitochondrion	R-HSA-6787450	8.450700e-01	0.073
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	8.450700e-01	0.073
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.458771e-01	0.073
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	8.458771e-01	0.073
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	8.484758e-01	0.071
Somitogenesis	R-HSA-9824272	8.484758e-01	0.071
FCERI mediated NF-kB activation	R-HSA-2871837	8.492367e-01	0.071
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.502202e-01	0.070
GABA receptor activation	R-HSA-977443	8.524025e-01	0.069
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.524025e-01	0.069
Diseases of DNA repair	R-HSA-9675135	8.571494e-01	0.067
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.582431e-01	0.066
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	8.582431e-01	0.066
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.582431e-01	0.066
GDP-fucose biosynthesis	R-HSA-6787639	8.582431e-01	0.066
Regulation of NPAS4 gene expression	R-HSA-9768759	8.582431e-01	0.066
Choline catabolism	R-HSA-6798163	8.582431e-01	0.066
Formation of paraxial mesoderm	R-HSA-9793380	8.600131e-01	0.065
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	8.602460e-01	0.065
Formation of the cornified envelope	R-HSA-6809371	8.615563e-01	0.065
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.672859e-01	0.062
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.695903e-01	0.061
Heme degradation	R-HSA-189483	8.695903e-01	0.061
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	8.702969e-01	0.060
RNA Polymerase III Transcription Termination	R-HSA-73980	8.702969e-01	0.060
FOXO-mediated transcription of cell death genes	R-HSA-9614657	8.702969e-01	0.060
Apoptotic factor-mediated response	R-HSA-111471	8.702969e-01	0.060
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	8.702969e-01	0.060
Vitamin D (calciferol) metabolism	R-HSA-196791	8.702969e-01	0.060
Class B/2 (Secretin family receptors)	R-HSA-373080	8.714188e-01	0.060
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.783567e-01	0.056
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.783567e-01	0.056
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.783567e-01	0.056
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.783567e-01	0.056
CD22 mediated BCR regulation	R-HSA-5690714	8.808610e-01	0.055
Pre-NOTCH Processing in Golgi	R-HSA-1912420	8.813264e-01	0.055
PI-3K cascade:FGFR3	R-HSA-5654710	8.813264e-01	0.055
O2/CO2 exchange in erythrocytes	R-HSA-1480926	8.813264e-01	0.055
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	8.813264e-01	0.055
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.813264e-01	0.055
Other interleukin signaling	R-HSA-449836	8.813264e-01	0.055
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.838683e-01	0.054
PERK regulates gene expression	R-HSA-381042	8.865760e-01	0.052
Transferrin endocytosis and recycling	R-HSA-917977	8.865760e-01	0.052
PI3K Cascade	R-HSA-109704	8.876317e-01	0.052
Signaling by FGFR2 in disease	R-HSA-5655253	8.876317e-01	0.052
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	8.892315e-01	0.051
Protein localization	R-HSA-9609507	8.910485e-01	0.050
Regulation of PD-L1(CD274) translation	R-HSA-9909620	8.914185e-01	0.050
PI-3K cascade:FGFR4	R-HSA-5654720	8.914185e-01	0.050
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	8.914185e-01	0.050
Signaling by NODAL	R-HSA-1181150	8.914185e-01	0.050
Acyl chain remodelling of PI	R-HSA-1482922	8.914185e-01	0.050
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.914185e-01	0.050
Eicosanoid ligand-binding receptors	R-HSA-391903	8.914185e-01	0.050
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.927568e-01	0.049
Glycosphingolipid transport	R-HSA-9845576	8.942778e-01	0.049
Triglyceride catabolism	R-HSA-163560	8.942778e-01	0.049
FGFR2 mutant receptor activation	R-HSA-1839126	8.942778e-01	0.049
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.963356e-01	0.048
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	8.982784e-01	0.047
Mitochondrial protein degradation	R-HSA-9837999	8.982784e-01	0.047
Innate Immune System	R-HSA-168249	8.994506e-01	0.046
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.006530e-01	0.045
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.006530e-01	0.045
Abacavir metabolism	R-HSA-2161541	9.006530e-01	0.045
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.006530e-01	0.045
Zygotic genome activation (ZGA)	R-HSA-9819196	9.006530e-01	0.045
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.006530e-01	0.045
Acyl chain remodelling of PG	R-HSA-1482925	9.006530e-01	0.045
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.091026e-01	0.041
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.091026e-01	0.041
Attachment and Entry	R-HSA-9694614	9.091026e-01	0.041
Potassium Channels	R-HSA-1296071	9.119682e-01	0.040
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.145579e-01	0.039
G alpha (q) signalling events	R-HSA-416476	9.160722e-01	0.038
PI-3K cascade:FGFR1	R-HSA-5654689	9.168340e-01	0.038
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.168340e-01	0.038
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	9.168340e-01	0.038
Signaling by KIT in disease	R-HSA-9669938	9.168340e-01	0.038
Cellular hexose transport	R-HSA-189200	9.168340e-01	0.038
Neurotoxicity of clostridium toxins	R-HSA-168799	9.168340e-01	0.038
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.204638e-01	0.036
Interleukin-2 family signaling	R-HSA-451927	9.204638e-01	0.036
Extracellular matrix organization	R-HSA-1474244	9.217877e-01	0.035
Intrinsic Pathway for Apoptosis	R-HSA-109606	9.225046e-01	0.035
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.225046e-01	0.035
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.237679e-01	0.034
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	9.237679e-01	0.034
Regulation of PTEN mRNA translation	R-HSA-8943723	9.239083e-01	0.034
Termination of O-glycan biosynthesis	R-HSA-977068	9.239083e-01	0.034
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	9.239083e-01	0.034
Interleukin receptor SHC signaling	R-HSA-912526	9.239083e-01	0.034
Formation of the ureteric bud	R-HSA-9830674	9.239083e-01	0.034
Mitochondrial mRNA modification	R-HSA-9937008	9.239083e-01	0.034
Carnitine shuttle	R-HSA-200425	9.239083e-01	0.034
Maturation of spike protein	R-HSA-9694548	9.259838e-01	0.033
Transcriptional Regulation by VENTX	R-HSA-8853884	9.259838e-01	0.033
IRS-mediated signalling	R-HSA-112399	9.272473e-01	0.033
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.303811e-01	0.031
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.303811e-01	0.031
TRAF6 mediated NF-kB activation	R-HSA-933542	9.303811e-01	0.031
Mitochondrial RNA degradation	R-HSA-9836573	9.303811e-01	0.031
Plasma lipoprotein assembly	R-HSA-8963898	9.303811e-01	0.031
Complex III assembly	R-HSA-9865881	9.303811e-01	0.031
Interleukin-6 family signaling	R-HSA-6783589	9.303811e-01	0.031
Scavenging by Class A Receptors	R-HSA-3000480	9.311406e-01	0.031
Regulation of beta-cell development	R-HSA-186712	9.359422e-01	0.029
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.359422e-01	0.029
PI-3K cascade:FGFR2	R-HSA-5654695	9.363037e-01	0.029
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.363037e-01	0.029
HDMs demethylate histones	R-HSA-3214842	9.363037e-01	0.029
Hyaluronan degradation	R-HSA-2160916	9.363037e-01	0.029
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.363037e-01	0.029
Laminin interactions	R-HSA-3000157	9.363037e-01	0.029
Leishmania phagocytosis	R-HSA-9664417	9.367630e-01	0.028
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.367630e-01	0.028
Parasite infection	R-HSA-9664407	9.367630e-01	0.028
Metabolism of polyamines	R-HSA-351202	9.399202e-01	0.027
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.417228e-01	0.026
Linoleic acid (LA) metabolism	R-HSA-2046105	9.417228e-01	0.026
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.417228e-01	0.026
Myogenesis	R-HSA-525793	9.417228e-01	0.026
Urea cycle	R-HSA-70635	9.417228e-01	0.026
Abacavir ADME	R-HSA-2161522	9.417228e-01	0.026
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.429599e-01	0.026
IRS-related events triggered by IGF1R	R-HSA-2428928	9.436683e-01	0.025
Peptide hormone metabolism	R-HSA-2980736	9.443829e-01	0.025
Signaling by FGFR3 in disease	R-HSA-5655332	9.466811e-01	0.024
Signaling by BMP	R-HSA-201451	9.466811e-01	0.024
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.466811e-01	0.024
Signaling by Insulin receptor	R-HSA-74752	9.472770e-01	0.024
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.505216e-01	0.022
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.512179e-01	0.022
Pyrimidine salvage	R-HSA-73614	9.512179e-01	0.022
Pyroptosis	R-HSA-5620971	9.512179e-01	0.022
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.522042e-01	0.021
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.522042e-01	0.021
Leishmania parasite growth and survival	R-HSA-9664433	9.526997e-01	0.021
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.526997e-01	0.021
IGF1R signaling cascade	R-HSA-2428924	9.536489e-01	0.021
Insulin receptor signalling cascade	R-HSA-74751	9.536489e-01	0.021
Metabolism of amino acids and derivatives	R-HSA-71291	9.549641e-01	0.020
Thyroxine biosynthesis	R-HSA-209968	9.553689e-01	0.020
Downstream signaling of activated FGFR3	R-HSA-5654708	9.553689e-01	0.020
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.565907e-01	0.019
NGF-stimulated transcription	R-HSA-9031628	9.587706e-01	0.018
DAP12 signaling	R-HSA-2424491	9.591668e-01	0.018
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	9.591668e-01	0.018
Downstream signaling of activated FGFR4	R-HSA-5654716	9.591668e-01	0.018
Neurotransmitter clearance	R-HSA-112311	9.591668e-01	0.018
Activation of BH3-only proteins	R-HSA-114452	9.591668e-01	0.018
Chemokine receptors bind chemokines	R-HSA-380108	9.617205e-01	0.017
Downstream signal transduction	R-HSA-186763	9.626418e-01	0.017
Post-translational protein phosphorylation	R-HSA-8957275	9.643541e-01	0.016
Complex IV assembly	R-HSA-9864848	9.670238e-01	0.015
Cardiogenesis	R-HSA-9733709	9.687303e-01	0.014
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.688488e-01	0.014
Parasitic Infection Pathways	R-HSA-9824443	9.702859e-01	0.013
Leishmania infection	R-HSA-9658195	9.702859e-01	0.013
Acyl chain remodelling of PC	R-HSA-1482788	9.713919e-01	0.013
Miscellaneous transport and binding events	R-HSA-5223345	9.713919e-01	0.013
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	9.713919e-01	0.013
PI Metabolism	R-HSA-1483255	9.716609e-01	0.012
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.727685e-01	0.012
Hyaluronan metabolism	R-HSA-2142845	9.738271e-01	0.012
Paracetamol ADME	R-HSA-9753281	9.755879e-01	0.011
Downstream signaling of activated FGFR2	R-HSA-5654696	9.760551e-01	0.011
Downstream signaling of activated FGFR1	R-HSA-5654687	9.760551e-01	0.011
Acyl chain remodelling of PE	R-HSA-1482839	9.760551e-01	0.011
ROS and RNS production in phagocytes	R-HSA-1222556	9.762174e-01	0.010
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.777820e-01	0.010
Lysosome Vesicle Biogenesis	R-HSA-432720	9.780936e-01	0.010
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	9.780936e-01	0.010
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.780936e-01	0.010
RNA Polymerase III Transcription	R-HSA-74158	9.780936e-01	0.010
Synthesis of PA	R-HSA-1483166	9.790197e-01	0.009
Dectin-2 family	R-HSA-5621480	9.790197e-01	0.009
NCAM1 interactions	R-HSA-419037	9.799587e-01	0.009
Lysine catabolism	R-HSA-71064	9.799587e-01	0.009
Metabolism of folate and pterines	R-HSA-196757	9.799587e-01	0.009
tRNA processing in the mitochondrion	R-HSA-6785470	9.816650e-01	0.008
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.816650e-01	0.008
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.816650e-01	0.008
Purine salvage	R-HSA-74217	9.816650e-01	0.008
Nuclear Receptor transcription pathway	R-HSA-383280	9.819085e-01	0.008
Triglyceride metabolism	R-HSA-8979227	9.819819e-01	0.008
Amino acid transport across the plasma membrane	R-HSA-352230	9.819819e-01	0.008
Collagen formation	R-HSA-1474290	9.822161e-01	0.008
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.832262e-01	0.007
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.832262e-01	0.007
RAB geranylgeranylation	R-HSA-8873719	9.833065e-01	0.007
rRNA processing in the mitochondrion	R-HSA-8868766	9.846546e-01	0.007
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.851627e-01	0.006
NCAM signaling for neurite out-growth	R-HSA-375165	9.856778e-01	0.006
PPARA activates gene expression	R-HSA-1989781	9.857090e-01	0.006
G alpha (s) signalling events	R-HSA-418555	9.867709e-01	0.006
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.871359e-01	0.006
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.876679e-01	0.005
FOXO-mediated transcription	R-HSA-9614085	9.879064e-01	0.005
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.882507e-01	0.005
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.892515e-01	0.005
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.894772e-01	0.005
DAP12 interactions	R-HSA-2172127	9.901670e-01	0.004
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.901670e-01	0.004
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.901670e-01	0.004
Kidney development	R-HSA-9830369	9.902613e-01	0.004
Nicotinate metabolism	R-HSA-196807	9.902613e-01	0.004
SLC-mediated transport of amino acids	R-HSA-9958863	9.902613e-01	0.004
Gastrulation	R-HSA-9758941	9.916921e-01	0.004
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.924720e-01	0.003
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.928650e-01	0.003
ECM proteoglycans	R-HSA-3000178	9.928650e-01	0.003
Metabolism of cofactors	R-HSA-8978934	9.928650e-01	0.003
Metabolism of porphyrins	R-HSA-189445	9.928650e-01	0.003
Plasma lipoprotein remodeling	R-HSA-8963899	9.931133e-01	0.003
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.937001e-01	0.003
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.942369e-01	0.003
G alpha (i) signalling events	R-HSA-418594	9.943093e-01	0.002
FCGR activation	R-HSA-2029481	9.945341e-01	0.002
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.948409e-01	0.002
FCERI mediated MAPK activation	R-HSA-2871796	9.952118e-01	0.002
Interleukin-10 signaling	R-HSA-6783783	9.958805e-01	0.002
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.965883e-01	0.001
Metabolism of amine-derived hormones	R-HSA-209776	9.966230e-01	0.001
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.971742e-01	0.001
Collagen degradation	R-HSA-1442490	9.978371e-01	0.001
Nucleotide salvage	R-HSA-8956321	9.978371e-01	0.001
Cell surface interactions at the vascular wall	R-HSA-202733	9.979141e-01	0.001
Signaling by PDGF	R-HSA-186797	9.980215e-01	0.001
Keratinization	R-HSA-6805567	9.980896e-01	0.001
Complex I biogenesis	R-HSA-6799198	9.981902e-01	0.001
Digestion and absorption	R-HSA-8963743	9.981902e-01	0.001
Neurotransmitter release cycle	R-HSA-112310	9.985353e-01	0.001
O-linked glycosylation of mucins	R-HSA-913709	9.988411e-01	0.001
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.988411e-01	0.001
Visual phototransduction	R-HSA-2187338	9.989247e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.989994e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.990304e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.991016e-01	0.000
Purine catabolism	R-HSA-74259	9.991888e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.991939e-01	0.000
Aspirin ADME	R-HSA-9749641	9.992580e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.993792e-01	0.000
Transport of small molecules	R-HSA-382551	9.994725e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.995250e-01	0.000
Respiratory electron transport	R-HSA-611105	9.995515e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.995655e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.997361e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.997836e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.997880e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.998101e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.998220e-01	0.000
Drug ADME	R-HSA-9748784	9.998958e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999271e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999310e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999443e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999531e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999630e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999657e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999771e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999809e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999866e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999950e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999950e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999958e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999972e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999975e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.999978e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999980e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999980e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999985e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999989e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999995e-01	0.000
Complement cascade	R-HSA-166658	9.999995e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999999e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999999e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999999e-01	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000