AURB

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A1L429	S7	Sugiyama	GAGE12B; GAGE12C; GAGE12D; GAGE12E	______________MSWRGRsTyyWPRPRRYVQPPEMIGPM
A6NDE8	S7	Sugiyama	GAGE12H	______________MSWRGRsTyyWPRPRRYVQPPEMIGPM
A6NER3	S7	Sugiyama	GAGE12J	______________MSWRGRsTyyWPRPRPYVQPPEMIGPM
A6NMY6	S164	Sugiyama	ANXA2P2 ANX2L2 ANX2P2 LPC2B	NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGS
O00458	S15	Sugiyama	IFRD1	______MPKNKKRNtPHRGssAGGGGsGAAAATAATAGGQH
O00458	T9	Sugiyama	IFRD1	____________MPKNKKRNtPHRGssAGGGGsGAAAATAA
O00469	S600	Sugiyama	PLOD2	VEEMEHyGKWSGGKHHDsRIsGGyENVPTDDIHMKQVDLEN
O00562	S664	Sugiyama	PITPNM1 DRES9 NIR2 PITPNM	SQNSLQAAPATTSSWEPRRAstAFCPPAASSEAPDGPSSTA
O00566	T332	EPSD\|PSP	MPHOSPH10 MPP10	DDDLQENEDNKQHKESLKRVtFALPDDAETEDTGVLNVKKN
O00571	S594	EPSD\|PSP\|Sugiyama	DDX3X DBX DDX3	MAyEHHyKGssRGRSKssRFsGGFGARDYRQssGAssssFs
O00571	S605	Sugiyama	DDX3X DBX DDX3	RGRSKssRFsGGFGARDYRQssGAssssFsssRAsSsRSGG
O00571	S82	Sugiyama	DDX3X DBX DDX3	ssKDKDAyssFGsRsDsRGKssFFsDRGsGsRGRFDDRGRs
O14617	S658	Sugiyama	AP3D1 PRO0039	DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14618	S267	Sugiyama	CCS	DGLTIWEERGRPIAGKGRKEsAQPPAHL_____________
O14641	S651	Sugiyama	DVL2	LRRGGEAsGtsDGGPPPsRGstGGAPNLRAHPGLHPYGPPP
O14777	S15	SIGNOR\|EPSD\|PSP	NDC80 HEC HEC1 KNTC2	______MKRSsVsSGGAGRLsMQELRSQDVNKQGLYtPQTK
O14777	S44	SIGNOR\|EPSD\|PSP	NDC80 HEC HEC1 KNTC2	VNKQGLYtPQTKEKPTFGKLsINKPtsERKVsLFGKRtsGH
O14777	S5	SIGNOR\|EPSD\|PSP	NDC80 HEC HEC1 KNTC2	________________MKRSsVsSGGAGRLsMQELRSQDVN
O14777	S55	EPSD\|PSP	NDC80 HEC HEC1 KNTC2	KEKPTFGKLsINKPtsERKVsLFGKRtsGHGsRNsQLGIFs
O14777	S69	EPSD\|PSP	NDC80 HEC HEC1 KNTC2	tsERKVsLFGKRtsGHGsRNsQLGIFsssEKIKDPRPLNDK
O14777	T49	EPSD\|PSP	NDC80 HEC HEC1 KNTC2	LYtPQTKEKPTFGKLsINKPtsERKVsLFGKRtsGHGsRNs
O14950	S20	EPSD\|PSP	MYL12B MRLC2 MYLC2B	_MSSKKAKTKTTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
O14974	S695	Sugiyama	PPP1R12A MBS MYPT1	DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974	T696	Sugiyama	PPP1R12A MBS MYPT1	EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O14980	S1055	Sugiyama	XPO1 CRM1	LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15212	T107	Sugiyama	PFDN6 HKE2 PFD6	IKRYESQLRDLERQsEQQREtLAQLQQEFQRAQAAKAGAPG
O15392	T117	SIGNOR\|ELM\|EPSD\|PSP	BIRC5 API4 IAP4	TLGEFLKLDRERAKNKIAKEtNNKKKEFEETAKKVRRAIEQ
O15392	T34	EPSD\|PSP	BIRC5 API4 IAP4	LKDHRIstFKNWPFLEGCACtPERMAEAGFIHCPtENEPDL
O15523	S592	EPSD\|PSP\|Sugiyama	DDX3Y DBY	MAyEHHyKGGSRGRSKSNRFsGGFGARDYRQSSGSSSSGFG
O43423	S100	Sugiyama	ANP32CP PP32R1	AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43823	S124	Sugiyama	AKAP8 AKAP95	SKEGGRGGsGGGGEGIQDREssFRFQPFESYDSRPCLPEHN
O43847	S94	Sugiyama	NRDC NRD1	ENSRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYR
O60716	Y865	Sugiyama	CTNND1 KIAA0384	KKsDFQVNLNNAsRsQssHsyDDstLPLIDRNQKsDKKPDR
O60814	S37	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814	S39	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60814	S79	EPSD	H2BC12 H2BFT HIRIP1 HIST1H2BK	AMGIMNsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAV
O60814	Y38	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
O60814	Y84	EPSD	H2BC12 H2BFT HIRIP1 HIST1H2BK	NsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAVRLLLP
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841	T78	Sugiyama	EIF5B IF2 KIAA0741	ILKELEELsLEAQGIKADREtVAVKPTENNEEEFtsKDKKK
O60879	S196	SIGNOR	DIAPH2 DIA	DEKLLNCLESLRVSLTSNPVsWVNNFGHEGLGLLLDELEKL
O75157	S205	Sugiyama	TSC22D2 KIAA0669 TILZ4	yYERDSDSSVLTRSGDCIRHssTFDQTAERDSGLGATGGSV
O75348	T71	Sugiyama	ATP6V1G1 ATP6G ATP6G1 ATP6J	REKEFKAKEAAALGsRGsCstEVEKETQEKMTILQtyFRQN
O75665	S899	Sugiyama	OFD1 CXorf5	EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O75821	S28	Sugiyama	EIF3G EIF3S4	sKPsWADQVEEEGEDDKCVtsELLKGIPLAtGDtsPEPELL
O76021	T312	EPSD\|PSP	RSL1D1 CATX11 CSIG PBK1 L12	RERNFEKQKERKKKRQQARKtAsVLsKDDVAPEsGDtTVKK
O76087	S7	Sugiyama	GAGE7 GAGE12I GAGE7B	______________MSWRGRsTyyWPRPRRYVQPPEMIGPM
O94763	S188	Sugiyama	URI1 C19orf2 NNX3 PPP1R19 RMP URI	DFEFKAKHRIAHKPHSKPKTsDIFEADIANDVKSKDLLADK
O95229	S250	SIGNOR\|PSP	ZWINT	AEAENLPDDKPQQPTRPQEQstGDTMGRDPGVsFKAVGLQP
O95229	S262	SIGNOR\|PSP	ZWINT	QPTRPQEQstGDTMGRDPGVsFKAVGLQPAGDVNLP_____
O95229	T251	SIGNOR\|PSP	ZWINT	EAENLPDDKPQQPTRPQEQstGDTMGRDPGVsFKAVGLQPA
O95235	S878	SIGNOR\|EPSD\|PSP	KIF20A MKLP2 RAB6KIFL	PtCQSStDCsPyARILRSRRsPLLKsGPFGKKY________
O95239	S801	PSP	KIF4A KIF4	LKEKKESGENPPPKLRRRtFsLtEVRGQVsEsEDsItKQIE
O95239	T799	SIGNOR\|EPSD\|PSP	KIF4A KIF4	AQLKEKKESGENPPPKLRRRtFsLtEVRGQVsEsEDsItKQ
O95456	S180	Sugiyama	PSMG1 C21LRP DSCR2 PAC1	KNMQITILTCRHVTDYKTSEsTGsLPsPFLRALKTQNFKDS
O95626	S104	Sugiyama	ANP32D PP32R2	AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95714	S2928	Sugiyama	HERC2	ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
O95817	S195	Sugiyama	BAG3 BIS	AAsDCsssSsSAsLPssGRssLGsHQLPRGyISIPVIHEQN
O95817	S284	Sugiyama	BAG3 BIS	sPFRssVQGAssREGsPARsstPLHsPsPIRVHtVVDRPQQ
O95831	S100	Sugiyama	AIFM1 AIF PDCD8	AGAYAYKTMKEDEKRyNERIsGLGLtPEQKQKKAALsAsEG
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00491	S163	Sugiyama	PNP NP	GQNPLRGPNDERFGDRFPAMsDAyDRtMRQRALstWKQMGE
P00491	S176	Sugiyama	PNP NP	GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00558	S174	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558	S175	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P00558	Y161	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P02545	S437	Sugiyama	LMNA LMN1	KKRKLEstEsRssFsQHARtsGRVAVEEVDEEGKFVRLRNK
P02545	T436	Sugiyama	LMNA LMN1	tKKRKLEstEsRssFsQHARtsGRVAVEEVDEEGKFVRLRN
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083	S170	Sugiyama	ANXA1 ANX1 LPC1	RDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsE
P04083	S173	Sugiyama	ANXA1 ANX1 LPC1	NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04083	S182	Sugiyama	ANXA1 ANX1 LPC1	RDLAKDItsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsD
P04083	S189	Sugiyama	ANXA1 ANX1 LPC1	tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04637	S183	SIGNOR\|EPSD\|PSP	TP53 P53	YKQSQHMTEVVRRCPHHERCsDsDGLAPPQHLIRVEGNLRV
P04637	S215	SIGNOR\|EPSD\|PSP	TP53 P53	IRVEGNLRVEYLDDRNtFRHsVVVPyEPPEVGSDCTTIHYN
P04637	S269	SIGNOR\|EPSD\|PSP	TP53 P53	RPILTIITLEDSSGNLLGRNsFEVRVCACPGRDRRtEEENL
P04637	T211	SIGNOR\|EPSD\|PSP	TP53 P53	PQHLIRVEGNLRVEYLDDRNtFRHsVVVPyEPPEVGSDCTT
P04637	T284	SIGNOR\|EPSD\|PSP	TP53 P53	LLGRNsFEVRVCACPGRDRRtEEENLRKKGEPHHELPPGSt
P04792	S78	Sugiyama	HSPB1 HSP27 HSP28	LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05204	S25	EPSD\|PSP	HMGN2 HMG17	KAEGDAKGDKAKVKDEPQRRsARLsAKPAPPKPEPKPKKAP
P05204	S29	EPSD\|PSP	HMGN2 HMG17	DAKGDKAKVKDEPQRRsARLsAKPAPPKPEPKPKKAPAKKG
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05787	S291	Sugiyama	KRT8 CYK8	ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P05787	S330	Sugiyama	KRT8 CYK8	MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P05787	T6	EPSD\|PSP	KRT8 CYK8	_______________MSIRVtQKsYKVSTSGPRAFSSRsYT
P06400	S780	EPSD\|PSP	RB1	FMQRLKtNILQyAstRPPtLsPIPHIPRsPyKFPssPLRIP
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06748	S125	PSP	NPM1 NPM	GsGPVHIsGQHLVAVEEDAEsEDEEEEDVKLLsIsGKRsAP
P06899	S79	EPSD	H2BC11 H2BFR HIST1H2BJ	AMGIMNSFVNDIFERIAGEAsRLAHyNKRSTITSREIQTAV
P06899	Y84	EPSD	H2BC11 H2BFR HIST1H2BJ	NSFVNDIFERIAGEAsRLAHyNKRSTITSREIQTAVRLLLP
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	T302	Sugiyama	LDHB	YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205	Y161	Sugiyama	PGK2 PGKB	KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07355	S164	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGs
P07384	S474	Sugiyama	CAPN1 CANPL1 PIG30	GQPAVHLKRDFFLANAsRARsEQFINLREVSTRFRLPPGEY
P07602	S29	Sugiyama	PSAP GLBA SAP1	SLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVKHCL
P07737	T65	Sugiyama	PFN1	PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07814	S1511	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	PGAKCVCGKNPAKyytLFGRsy___________________
P07814	S739	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07814	T1506	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	LCELQPGAKCVCGKNPAKyytLFGRsy______________
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	T317	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08174	S54	Sugiyama	CD55 CR DAF	GDCGLPPDVPNAQPALEGRTsFPEDtVItyKCEEsFVKIPG
P08238	S255	EPSD\|PSP	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	GEKEEEDKDDEEKPKIEDVGsDEEDDsGKDKKKKTKKIKEK
P08238	S45	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238	S452	EPSD\|PSP\|Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	S470	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs
P08238	T309	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238	T467	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08670	S325	Sugiyama	VIM	NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P08670	S72	EPSD	VIM	LyAssPGGVyAtRssAVRLRssVPGVRLLQDsVDFsLADAI
P08670	S73	SIGNOR\|ELM\|EPSD\|PSP	VIM	yAssPGGVyAtRssAVRLRssVPGVRLLQDsVDFsLADAIN
P08865	S75	Sugiyama	RPSA LAMBR LAMR1	WEKLLLAARAIVAIENPADVsVIssRNtGQRAVLKFAAAtG
P08865	T82	Sugiyama	RPSA LAMBR LAMR1	ARAIVAIENPADVsVIssRNtGQRAVLKFAAAtGAtPIAGR
P09525	T127	Sugiyama	ANXA4 ANX4	GCLIEILASRTPEEIRRIsQtYQQQYGRSLEDDIRSDTSFM
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09972	S45	Sugiyama	ALDOC ALDC	APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P0CL80	S7	Sugiyama	GAGE12F	______________MSWRGRsTyyWPRPRRYVQPPEMIGPM
P0DSO3	S7	Sugiyama	GAGE4	______________MSWRGRsTyyWPRPRRYVQPPEMIGPM
P10412	S27	SIGNOR	H1-4 H1F4 HIST1H1E	AAPAAPAPAEKtPVKKKARKsAGAAKRKAsGPPVsELItKA
P10412	S36	Sugiyama	H1-4 H1F4 HIST1H1E	EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10412	S41	Sugiyama	H1-4 H1F4 HIST1H1E	KKKARKsAGAAKRKAsGPPVsELItKAVAASKERsGVsLAA
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10809	S398	Sugiyama	HSPD1 HSP60	LDVttsEyEKEKLNERLAKLsDGVAVLKVGGtsDVEVNEKK
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11940	S51	Sugiyama	PABPC1 PAB1 PABP PABP1 PABPC2	FSPAGPILsIRVCRDMITRRsLGyAyVNFQQPADAERALDt
P12277	T322	Sugiyama	CKB CKBB	LGKHEKFsEVLKRLRLQKRGtGGVDtAAVGGVFDVsNADRL
P12277	T327	Sugiyama	CKB CKBB	KFsEVLKRLRLQKRGtGGVDtAAVGGVFDVsNADRLGFSEV
P13489	S290	Sugiyama	RNH1 PRI RNH	AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639	S584	Sugiyama	EEF2 EF2	DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13639	Y730	Sugiyama	EEF2 EF2	HADAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQ
P13807	S710	Sugiyama	GYS1 GYS	APEWPRRAsCTsSTSGSKRNsVDtAtsssLstPsEPLsPts
P13861	S58	Sugiyama	PRKAR2A PKR2 PRKAR2	TRLREARAPAsVLPAAtPRQsLGHPPPEPGPDRVADAKGDs
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14136	S13	SIGNOR\|ELM\|EPSD\|PSP	GFAP	________MERRRItsAARRsYVssGEMMVGGLAPGRRLGP
P14136	S38	SIGNOR\|ELM\|EPSD\|PSP	GFAP	GEMMVGGLAPGRRLGPGTRLsLARMPPPLPTRVDFSLAGAL
P14136	T7	SIGNOR\|ELM\|EPSD\|PSP	GFAP	______________MERRRItsAARRsYVssGEMMVGGLAP
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618	S202	Sugiyama	PKM OIP3 PK2 PK3 PKM2	SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618	S346	Sugiyama	PKM OIP3 PK2 PK3 PKM2	CAtQMLEsMIKKPRPTRAEGsDVANAVLDGADCIMLSGEtA
P14618	S97	Sugiyama	PKM OIP3 PK2 PK3 PKM2	sHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGP
P14618	T45	PSP\|Sugiyama	PKM OIP3 PK2 PK3 PKM2	TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14618	T95	Sugiyama	PKM OIP3 PK2 PK3 PKM2	NFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTK
P14625	S106	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14866	S543	Sugiyama	HNRNPL HNRPL P/OKcl.14	ELGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLN
P14866	S544	Sugiyama	HNRNPL HNRPL P/OKcl.14	LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P15408	S309	Sugiyama	FOSL2 FRA2	EQESPASPSESCSKAHRRssssGDQssDsLNsPtLLAL___
P15408	S310	Sugiyama	FOSL2 FRA2	QESPASPSESCSKAHRRssssGDQssDsLNsPtLLAL____
P16070	S43	Sugiyama	CD44 LHR MDU2 MDU3 MIC4	DLNITCRFAGVFHVEKNGRYsIsRtEAADLCKAFNSTLPTM
P16070	S71	Sugiyama	CD44 LHR MDU2 MDU3 MIC4	DLCKAFNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRI
P16402	S37	Sugiyama	H1-3 H1F3 HIST1H1D	KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16402	S42	Sugiyama	H1-3 H1F3 HIST1H1D	KKAKKAGATAGKRKAsGPPVsELItKAVAASKERsGVsLAA
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	S36	Sugiyama	H1-2 H1F2 HIST1H1C	EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17661	S12	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	DES	_________MSQAYSSsQRVssYRRtFGGAPGFPLGsPLss
P17661	S60	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	DES	FGsKGssssVTSRVYQVSRtsGGAGGLGsLRAsRLGttRtP
P17661	T17	SIGNOR\|ELM\|EPSD\|PSP	DES	____MSQAYSSsQRVssYRRtFGGAPGFPLGsPLssPVFPR
P17987	S35	Sugiyama	TCP1 CCT1 CCTA	EtIRsQNVMAAAsIANIVKssLGPVGLDKMLVDDIGDVTIT
P17987	S551	Sugiyama	TCP1 CCT1 CCTA	IKLHPESKDDKHGsyEDAVHsGALND_______________
P18615	S131	EPSD\|PSP	NELFE RD RDBP	QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P19174	S1233	Sugiyama	PLCG1 PLC1	PAKENGDLsPFsGtsLRERGsDASGQLFHGRAREGsFEsRy
P19338	S328	Sugiyama	NCL	NLFVGNLNFNKSAPELKtGIsDVFAKNDLAVVDVRIGMTRK
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22626	S201	Sugiyama	HNRNPA2B1 HNRPA2B1	NAEVRKALsRQEMQEVQssRsGRGGNFGFGDsRGGGGNFGP
P23142	S247	Sugiyama	FBLN1 PP213	CRLGESCINTVGSFRCQRDssCGtGYELTEDNSCKDIDECE
P23527	S79	EPSD	H2BC17 H2BFH H2BFN HIST1H2BO	AMGIMNSFVNDIFERIAGEAsRLAHyNKRSTITSREIQTAV
P23527	Y84	EPSD	H2BC17 H2BFH H2BFN HIST1H2BO	NSFVNDIFERIAGEAsRLAHyNKRSTITSREIQTAVRLLLP
P23921	S780	Sugiyama	RRM1 RR1	KEKVSKEEEEKERNtAAMVCsLENRDECLMCGS________
P23921	T774	Sugiyama	RRM1 RR1	KEKLKDKEKVSKEEEEKERNtAAMVCsLENRDECLMCGS__
P25205	S447	Sugiyama	MCM3	EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25398	S107	Sugiyama	RPS12	EWVGLCKIDREGKPRKVVGCsCVVVKDYGKESQAKDVIEEy
P25490	S180	SIGNOR	YY1 INO80S	GGGGSSSSGGGRVKKGGGKKsGKKsYLsGGAGAAGGGGADP
P25490	S184	SIGNOR\|EPSD\|PSP	YY1 INO80S	SSSSGGGRVKKGGGKKsGKKsYLsGGAGAAGGGGADPGNKK
P25786	S211	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	GLRALRETLPAEQDLttKNVsIGIVGKDLEFTIyDDDDVsP
P25789	T10	Sugiyama	PSMA4 HC9 PSC9	___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P25963	S262	PSP	NFKBIA IKBA MAD3 NFKBI	DVNRVTYQGYSPYQLTWGRPsTRIQQQLGQLTLENLQMLPE
P25963	S32	PSP	NFKBIA IKBA MAD3 NFKBI	AMEGPRDGLKKERLLDDRHDsGLDsMKDEEyEQMVKELQEI
P25963	S63	PSP	NFKBIA IKBA MAD3 NFKBI	EQMVKELQEIRLEPQEVPRGsEPWKQQLTEDGDSFLHLAII
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26232	T657	Sugiyama	CTNNA2 CAPR	EDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T107	Sugiyama	RPL13 BBC1 OK/SW-cl.46	HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27695	S129	Sugiyama	APEX1 APE APE1 APEX APX HAP1 REF1	QELPGLSHQYWSAPsDKEGysGVGLLsRQCPLKVsyGIGDE
P27708	S1859	Sugiyama	CAD	RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P28066	S174	Sugiyama	PSMA5	FHMDPsGtFVQCDARAIGsAsEGAQssLQEVyHKSMTLKEA
P28074	S229	Sugiyama	PSMB5 LMPX MB1 X	EQAyDLARRAIyQATYRDAysGGAVNLyHVREDGWIRVSsD
P29401	S305	Sugiyama	TKT	LAtPPQEDAPsVDIANIRMPsLPsyKVGDKIATRKAYGQAL
P29692	S44	Sugiyama	EEF1D EF1D	RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692	S60	Sugiyama	EEF1D EF1D	ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P29692	S64	Sugiyama	EEF1D EF1D	sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P30044	S182	Sugiyama	PRDX5 ACR1 SBBI10	DLLLDDsLVsIFGNRRLKRFsMVVQDGIVKALNVEPDGTGL
P30086	S52	Sugiyama	PEBP1 PBP PEBP	AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086	T51	Sugiyama	PEBP1 PBP PEBP	GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P30101	S98	Sugiyama	PDIA3 ERP57 ERP60 GRP58	VPLAKVDCTANTNTCNKyGVsGyPtLKIFRDGEEAGAyDGP
P30520	S448	Sugiyama	ADSS2 ADSS	yVRFIEDELQIPVKWIGVGKsREsMIQLF____________
P30520	S451	Sugiyama	ADSS2 ADSS	FIEDELQIPVKWIGVGKsREsMIQLF_______________
P30533	S242	Sugiyama	LRPAP1 A2MRAP	TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31939	S554	Sugiyama	ATIC PURH OK/SW-cl.86	VSISSDAFFPFRDNVDRAKRsGVAyIAAPSGsAADKVVIEA
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P32119	S112	Sugiyama	PRDX2 NKEFB TDPX1	KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P33316	S120	Sugiyama	DUT	PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33778	S79	EPSD	H2BC3 H2BFF HIST1H2BB	AMGIMNSFVNDIFERIAGEAsRLAHyNKRSTITSREIQTAV
P33778	Y84	EPSD	H2BC3 H2BFF HIST1H2BB	NSFVNDIFERIAGEAsRLAHyNKRSTITSREIQTAVRLLLP
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932	S647	Sugiyama	HSPA4 APG2 HSPH2	EMRDKLSGEYEKFVSEDDRNsFtLKLEDTENWLyEDGEDQP
P34932	S76	Sugiyama	HSPA4 APG2 HSPH2	VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35221	T658	Sugiyama	CTNNA1	LDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P35580	T1847	PSP	MYH10	EEQLEQEAKERAAANKLVRRtEKKLKEIFMQVEDERRHADQ
P35659	T67	EPSD\|PSP	DEK	EKEKsLIVEGKREKKKVERLtMQVssLQREPFTIAQGKGQK
P36551	T111	Sugiyama	CPOX CPO CPX	AAFGHVQRAEMLPKTSGTRAtsLGRPEEEEDELAHRCSSFM
P36578	S87	Sugiyama	RPL4 RPL1	WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37802	T190	Sugiyama	TAGLN2 KIAA0120 CDABP0035	GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P37802	Y192	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NVIGLQMGtNRGAsQAGMtGyGMPRQIL_____________
P37837	S13	Sugiyama	TALDO1 TAL TALDO TALDOR	________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38159	S326	EPSD\|PSP	RBMX HNRPG RBMXP1	GssRYDDysssRDGyGGsRDsysssRsDLYssGRDRVGRQE
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P39687	S104	Sugiyama	ANP32A C15orf1 LANP MAPM PHAP1	AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P41091	S107	Sugiyama	EIF2S3 EIF2G	KIYKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLV
P42166	S159	Sugiyama	TMPO LAP2	RKLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsND
P42167	S159	Sugiyama	TMPO LAP2	RKLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSND
P42677	T74	Sugiyama	RPS27 MPS1	VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243	S195	Sugiyama	MATR3 KIAA0723	RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P45973	S92	EPSD\|PSP	CBX5 HP1A	KMKEGENNKPREKSESNKRKsNFsNsADDIKSKKKREQsND
P46013	S299	Sugiyama	MKI67	GLQGETQLLVSRKSRPKsGGsGHAVAEPAsPEQELDQNKGK
P46013	S374	EPSD\|PSP	MKI67	QQNsPQKHKNKDLYTtGRREsVNLGKSEGFKAGDKTLTPRK
P46013	S538	EPSD\|PSP	MKI67	DENLPPNtPLKRGEAPTKRKsLVMHtPPVLKKIIKEQPQPS
P46013	S648	Sugiyama	MKI67	RVSISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLG
P46459	S207	Sugiyama	NSF	KAENSSLNLIGKAKTKENRQsIINPDWNFEKMGIGGLDKEF
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46778	S104	EPSD\|PSP	RPL21	ILAKRINVRIEHIKHSKSRDsFLKRVKENDQKKKEAKEKGt
P46779	S115	Sugiyama	RPL28	HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P46779	T89	Sugiyama	RPL28	GQRKPAtsyVRttINKNARAtLsSIRHMIRKNKYRPDLRMA
P46783	T118	EPSD\|PSP\|Sugiyama	RPS10	RPETGRPRPKGLEGERPARLtRGEADRDTYRRSAVPPGADK
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P47712	S729	Sugiyama	PLA2G4A CPLA2 PLA2G4	KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA
P48643	S51	Sugiyama	CCT5 CCTE KIAA0098	LEALKSHIMAAKAVANtMRtsLGPNGLDKMMVDKDGDVtVT
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321	S659	Sugiyama	NASP	IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst
P49327	S1997	Sugiyama	FASN FAS	DGLLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFV
P49450	S7	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CENPA	______________MGPRRRsRKPEAPRRRsPsPtPtPGPs
P49589	S312	Sugiyama	CARS1 CARS	GDQKALQEGEGDLsIsADRLsEKRSPNDFALWKASKPGEPS
P49736	S229	Sugiyama	MCM2 BM28 CCNL1 CDCL1 KIAA0030	sHGHNVFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLP
P49792	S786	Sugiyama	RANBP2 NUP358	GsLRNADsEIKHstPsPtRYsLsPsKsyKYsPKtPPRWAED
P50395	S396	Sugiyama	GDI2 RABGDIB	IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50395	S427	Sugiyama	GDI2 RABGDIB	ttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED__
P50991	S51	Sugiyama	CCT4 CCTD SRB	AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt
P50991	T50	Sugiyama	CCT4 CCTD SRB	PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51659	S185	Sugiyama	HSD17B4 EDH17B4 SDR8C1	SAAKLGLLGLANSLAIEGRKsNIHCNtIAPNAGsRMTQTVM
P51991	S355	Sugiyama	HNRNPA3 HNRPA3	YSGQQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGs
P51991	S356	Sugiyama	HNRNPA3 HNRPA3	SGQQQSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsR
P52597	S54	Sugiyama	HNRNPF HNRPF	CtIHDGAAGVHFIYTREGRQsGEAFVELGsEDDVKMALKKD
P52789	T409	Sugiyama	HK2	TLAAVLQRIKENKGEERLRstIGVDGsVyKKHPHFAKRLHK
P52907	S123	Sugiyama	CAPZA1	KEAsDPQPEEADGGLKsWREsCDsALRAYVKDHYSNGFCTV
P53350	T210	EPSD\|PSP	PLK1 PLK	VKIGDFGLATKVEYDGERKKtLCGtPNyIAPEVLSKKGHSF
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53999	S118	Sugiyama	SUB1 PC4 RPO2TC1	PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54578	S431	Sugiyama	USP14 TGT	GSNNCGYYDLQAVLTHQGRSssSGHyVSWVKRKQDEWIKFD
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54750	S345	Sugiyama	PDE1A	EMVLSTDMSGHFQQIKNIRNsLQQPEGIDRAKTMSLILHAA
P55010	S10	Sugiyama	EIF5	___________MSVNVNRsVsDQFyRyKMPRLIAKVEGKGN
P56524	S265	SIGNOR	HDAC4 KIAA0288	AsEPNLKLRSRLKQKVAERRssPLLRRKDGPVVTALKKRPL
P57053	S37	Sugiyama	H2BC12L H2BFS H2BS1	KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053	S39	Sugiyama	H2BC12L H2BFS H2BS1	VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P57053	Y38	Sugiyama	H2BC12L H2BFS H2BS1	AVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssK
P57721	S158	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	AsQCGsLIGKGGSKIKEIREstGAQVQVAGDMLPNstERAV
P57721	S82	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK
P57721	T159	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	sQCGsLIGKGGSKIKEIREstGAQVQVAGDMLPNstERAVT
P58876	S37	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876	S39	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876	S79	EPSD	H2BC5 H2BFB HIRIP2 HIST1H2BD	AMGIMNsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAV
P58876	Y38	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
P58876	Y84	EPSD	H2BC5 H2BFB HIRIP2 HIST1H2BD	NsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAVRLLLP
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	S60	Sugiyama	ACTB	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709	Y53	Sugiyama	ACTB	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61247	S236	Sugiyama	RPS3A FTE1 MFTL	KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62241	S160	Sugiyama	RPS8 OK/SW-cl.83	KRSKKIQKKYDERKKNAKIssLLEEQFQQGKLLACIASRPG
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62269	Y95	Sugiyama	RPS18 D6S218E	RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62701	T247	Sugiyama	RPS4X CCG2 RPS4 SCAR	VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	S62	Sugiyama	ACTA2 ACTSA ACTVS GIG46	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736	Y55	Sugiyama	ACTA2 ACTSA ACTVS GIG46	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62750	S43	Sugiyama	RPL23A	KAKKAVLKGVHSHKKKKIRtsPTFRRPKTLRLRRQPKYPRK
P62753	S53	Sugiyama	RPS6 OK/SW-cl.2	AtEVAADALGEEWKGYVVRIsGGNDKQGFPMKQGVLTHGRV
P62805	S48	Sugiyama	H4C1 H4/A H4FA HIST1H4A; H4C2 H4/I H4FI HIST1H4B; H4C3 H4/G H4FG HIST1H4C; H4C4 H4/B H4FB HIST1H4D; H4C5 H4/J H4FJ HIST1H4E; H4C6 H4/C H4FC HIST1H4F; H4C8 H4/H H4FH HIST1H4H; H4C9 H4/M H4FM HIST1H4I; H4C11 H4/E H4FE HIST1H4J; H4C12 H4/D H4FD HIST1H4K; H4C13 H4/K H4FK HIST1H4L; H4C14 H4/N H4F2 H4FN HIST2H4 HIST2H4A; H4C15 H4/O H4FO HIST2H4B; H4C16 H4-16 HIST4H4	QGItKPAIRRLARRGGVKRIsGLIyEETRGVLKVFLENVIR
P62807	S37	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807	S39	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62807	S79	EPSD	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	AMGIMNsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAV
P62807	Y38	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	AVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssK
P62807	Y84	EPSD	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	NsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAVRLLLP
P62899	S15	Sugiyama	RPL31	______MAPAKKGGEKKKGRsAINEVVtREytINIHKRIHG
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62906	T9	Sugiyama	RPL10A NEDD6	____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917	S130	EPSD\|PSP\|Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917	S14	Sugiyama	RPL8	_______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62937	T157	Sugiyama	PPIA CYPA	NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104	S57	Sugiyama	YWHAZ	sNEERNLLsVAyKNVVGARRssWRVVssIEQKTEGAEKKQQ
P63104	S58	Sugiyama	YWHAZ	NEERNLLsVAyKNVVGARRssWRVVssIEQKTEGAEKKQQM
P63146	S142	Sugiyama	UBE2B RAD6B UBCH1	ANSQAAQLYQENKREYEKRVsAIVEQsWNDS__________
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	S60	Sugiyama	ACTG1 ACTG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261	Y53	Sugiyama	ACTG1 ACTG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	S61	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267	Y54	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809	S209	Sugiyama	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809	Y99	Sugiyama	YBX1 NSEP1 YB1	DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	S62	Sugiyama	ACTC1 ACTC	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032	Y55	Sugiyama	ACTC1 ACTC	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104	T432	Sugiyama	EEF1A1 EEF1A EF1A LENG7	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	S62	Sugiyama	ACTA1 ACTA	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133	Y55	Sugiyama	ACTA1 ACTA	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68431	S11	SIGNOR\|ELM\|EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	__________MARtKQtARKstGGKAPRKQLATKAARKsAP
P68431	S29	SIGNOR\|ELM\|EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	RKstGGKAPRKQLATKAARKsAPATGGVKKPHRyRPGtVAL
P68431	T4	EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	_________________MARtKQtARKstGGKAPRKQLATK
P78371	S470	Sugiyama	CCT2 99D8.1 CCTB	IADNAGYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAI
P78371	S60	Sugiyama	CCT2 99D8.1 CCTB	KSTLGPKGMDKILLsSGRDAsLMVtNDGAtILKNIGVDNPA
P78527	S511	EPSD\|PSP	PRKDC HYRC HYRC1	CSKPVVLPKGPEsEsEDHRAsGEVRtGKWKVPTYKDyVDLF
P82970	S20	EPSD\|PSP	HMGN5 NSBP1	_MPKRKAAGQGDMRQEPKRRsARLsAMLVPVtPEVKPKRTS
P82970	S24	EPSD\|PSP	HMGN5 NSBP1	RKAAGQGDMRQEPKRRsARLsAMLVPVtPEVKPKRTSSSRK
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84243	S11	SIGNOR\|ELM\|EPSD	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	__________MARtKQTARKstGGKAPRKQLATKAARKsAP
P84243	S29	ELM\|EPSD	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	RKstGGKAPRKQLATKAARKsAPsTGGVKKPHRyRPGtVAL
P98082	S723	Sugiyama	DAB2 DOC2	DANQLLNKINEPPKPAPRQVsLPVTKstDNAFENPFFKDsF
P98179	S147	EPSD\|PSP	RBM3 RNPL	yGyGRSRDYNGRNQGGYDRysGGNyRDNyDN__________
Q00610	S147	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	VYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLLL
Q00839	S14	PSP	HNRNPU C1orf199 HNRPU SAFA U21.1	_______MsssPVNVKKLKVsELKEELKKRRLsDKGLKAEL
Q00839	S26	PSP	HNRNPU C1orf199 HNRPU SAFA U21.1	VNVKKLKVsELKEELKKRRLsDKGLKAELMERLQAALDDEE
Q01082	S1670	Sugiyama	SPTBN1 SPTB2	QLSKTSRALVADSHPEsERIsMRQSKVDKLYAGLKDLAEER
Q01105	S166	Sugiyama	SET	yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q02241	S714	ELM\|EPSD	KIF23 KNSL5 MKLP1	YIAQISNGQQLMSQPQLHRRsNsCssISVASCISEWEQKIP
Q02241	S911	EPSD\|PSP	KIF23 KNSL5 MKLP1	QFTDIEtLKQEsPNGsRKRRsstVAPAQPDGAEsEWtDVET
Q02543	S123	Sugiyama	RPL18A	AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q02818	S369	Sugiyama	NUCB1 NUC	RFEEELAAREAELNAKAQRLsQETEALGRsQGRLEAQKREL
Q04695	S28	Sugiyama	KRT17	FTSSSsIKGSSGLGGGsSRTsCRLsGGLGAGsCRLGSAGGL
Q04695	S32	Sugiyama	KRT17	SsIKGSSGLGGGsSRTsCRLsGGLGAGsCRLGSAGGLGSTL
Q04837	S67	Sugiyama	SSBP1 SSBP	QVEGKNPVTIFSLATNEMWRsGDsEVyQLGDVsQKTTWHRI
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q05639	T432	Sugiyama	EEF1A2 EEF1AL STN	VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06210	S37	Sugiyama	GFPT1 GFAT GFPT	REILETLIKGLQRLEYRGYDsAGVGFDGGNDKDWEANACKI
Q06830	S30	Sugiyama	PRDX1 PAGA PAGB TDPX2	HPAPNFKAtAVMPDGQFKDIsLsDyKGKYVVFFFYPLDFTF
Q07021	S106	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	LsDEIKEERKIQKHKTLPKMsGGWELELNGTEAKLVRKVAG
Q07820	T301	PSP	MCL1 BCL2L3	INQESCIEPLAESITDVLVRtKRDWLVKQRGWDGFVEFFHV
Q07866	S524	Sugiyama	KLC1 KLC KNS2	QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q08211	S449	Sugiyama	DHX9 DDX9 LKP NDH2	FIQNDRAAECNIVVTQPRRIsAVsVAERVAFERGEEPGKSC
Q08211	S452	Sugiyama	DHX9 DDX9 LKP NDH2	NDRAAECNIVVTQPRRIsAVsVAERVAFERGEEPGKSCGYS
Q08J23	S139	SIGNOR\|iPTMNet\|EPSD\|PSP	NSUN2 SAKI TRM4	SWYPEELAWHTNLSRKILRKsPHLEKFHQFLVSETESGNIS
Q09028	S147	Sugiyama	RBBP4 RBAP48	VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q09161	S22	Sugiyama	NCBP1 CBP80 NCBP	SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q09666	T158	EPSD\|PSP	AHNAK PM227	GVEGDLGEtQsRTITVTRRVtAytVDVTGREGAKDIDIssP
Q12888	S1342	SIGNOR\|EPSD\|PSP	TP53BP1	sAMHSSGssGKGAGPLRGKtsGtEPADFALPssRGGPGKLs
Q12965	S1009	Sugiyama	MYO1E MYO1C	yTsMARPPLPRQQstssDRVsQtPEsLDFLKVPDQGAAGVR
Q12965	T936	Sugiyama	MYO1E MYO1C	LQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAP
Q13069	S7	Sugiyama	GAGE5	______________MSWRGRsTyyWPRPRRYVQPPEVIGPM
Q13070	S7	Sugiyama	GAGE6	______________MSWRGRsTyyWPRPRRYVQPPEVIGPM
Q13112	S410	Sugiyama	CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7	LNMRtPDtAKKTKsQtHRGssPGPRPVEGtPASRtQDPssP
Q13283	S67	Sugiyama	G3BP1 G3BP	sNGKPADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLN
Q13283	T71	Sugiyama	G3BP1 G3BP	PADAVyGQKEIHRKVMsQNFtNCHTKIRHVDAHATLNDGVV
Q13310	S51	Sugiyama	PABPC4 APP1 PABP4	FSPAGPVLsIRVCRDMITRRsLGyAyVNFQQPADAERALDt
Q13310	S96	Sugiyama	PABPC4 APP1 PABP4	VIKGKPIRIMWSQRDPsLRKsGVGNVFIKNLDKSIDNKALy
Q13315	S1403	SIGNOR\|EPSD\|PSP	ATM	SHVIKATFAYISNCHKTKLKsILEILSKSPDSYQKILLAIC
Q13435	S303	Sugiyama	SF3B2 SAP145	RQEEMNsQQEEEEMETDARssLGQsAsEtEEDtVsVsKKEK
Q13761	T14	EPSD\|PSP	RUNX3 AML2 CBFA3 PEBP2A3	_______MRIPVDPSTSRRFtPPsPAFPCGGGGGKMGENSG
Q13761	T173	EPSD\|PSP	RUNX3 AML2 CBFA3 PEBP2A3	tItVFTNPTQVATYHRAIKVtVDGPREPRRHRQKLEDQTKP
Q14152	S1028	Sugiyama	EIF3A EIF3S10 KIAA0139	NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152	S1188	Sugiyama	EIF3A EIF3S10 KIAA0139	PWRPLVKPGGWREKEKAREEsWGPPRESRPsEEREWDREKE
Q14152	S492	Sugiyama	EIF3A EIF3S10 KIAA0139	VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152	S988	Sugiyama	EIF3A EIF3S10 KIAA0139	PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14157	S852	Sugiyama	UBAP2L KIAA0144 NICE4	LDyysIPFPtPttPLtGRDGsLAsNPysGDLtKFGRGDASS
Q14160	S493	Sugiyama	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	RAtPHPSELKVMKRSIEGRRsEACPCQPDsGsPLPAEEEKR
Q14432	S293	Sugiyama	PDE3A	sQLIAGTKEDIPVFKRRRRsssVVsAEMSGCSSKSHRRtsL
Q14432	S294	Sugiyama	PDE3A	QLIAGTKEDIPVFKRRRRsssVVsAEMSGCSSKSHRRtsLP
Q14566	S271	Sugiyama	MCM6	VPDVSKLSTPGARAEtNsRVsGVDGyEtEGIRGLRALGVRD
Q14697	S187	Sugiyama	GANAB G2AN KIAA0088	LLsVNARGLLEFEHQRAPRVsQGsKDPAEGDGAQPEEtPRD
Q14847	S146	Sugiyama	LASP1 MLN50	FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q14847	Y152	Sugiyama	LASP1 MLN50	GPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPtsAPVyQ
Q14980	S1969	EPSD\|PSP	NUMA1 NMP22 NUMA	GTItDEEMKtGDPQETLRRAsMQPIQIAEGTGITTRQQRKR
Q14980	S1991	Sugiyama	NUMA1 NMP22 NUMA	QPIQIAEGTGITTRQQRKRVsLEPHQGPGtPEsKKATSCFP
Q14980	S2047	EPSD\|PSP	NUMA1 NMP22 NUMA	TTEAQKKAAPASTKQADRRQsMAFsILNtPKKLGNsLLRRG
Q14980	T1811	EPSD\|PSP	NUMA1 NMP22 NUMA	DsLGDVFLDsGRKtRSARRRttQIINITMTKKLDVEEPDsA
Q14980	T2055	EPSD\|PSP	NUMA1 NMP22 NUMA	APASTKQADRRQsMAFsILNtPKKLGNsLLRRGASKKALsK
Q15021	S585	Sugiyama	NCAPD2 CAPD2 CNAP1 KIAA0159	ILGLIFKGPAASTQEKNPREstGNMVTGQTVCKNKPNMsDP
Q15021	T586	Sugiyama	NCAPD2 CAPD2 CNAP1 KIAA0159	LGLIFKGPAASTQEKNPREstGNMVTGQTVCKNKPNMsDPE
Q15084	S389	Sugiyama	PDIA6 ERP5 P5 TXNDC7	FALLKGsFsEQGINEFLRELsFGRGstAPVGGGAFPtIVER
Q15084	S88	Sugiyama	PDIA6 ERP5 P5 TXNDC7	AATALKDVVKVGAVDADKHHsLGGQyGVQGFPtIKIFGSNK
Q15149	T2886	EPSD\|PSP	PLEC PLEC1	LLEAQAASGFLLDPVRNRRLtVNEAVKEGVVGPELHHKLLS
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15365	S126	Sugiyama	PCBP1	ATQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAI
Q15365	S50	Sugiyama	PCBP1	GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK
Q15365	T127	Sugiyama	PCBP1	TQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15366	S126	Sugiyama	PCBP2	AsQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAI
Q15366	S50	Sugiyama	PCBP2	GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK
Q15366	T127	Sugiyama	PCBP2	sQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15459	T474	Sugiyama	SF3A1 SAP114	EVyAPGLDIESsLKQLAERRtDIFGVEETAIGKKIGEEEIQ
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16576	S146	Sugiyama	RBBP7 RBAP46	VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16695	S29	EPSD	H3-4 H3FT HIST3H3	RKsTGGKAPRKQLATKVARKsAPATGGVKKPHRyRPGtVAL
Q16778	S79	EPSD	H2BC21 H2BFQ HIST2H2BE	AMGIMNsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAV
Q16778	Y84	EPSD	H2BC21 H2BFQ HIST2H2BE	NsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAVRLLLP
Q17R91	S196	PSP	DIAPH2	ELRSGISDEKLLNCLESLRVsLTSNPVSWVNNFGHEGLGLL
Q17R91	S820	PSP	DIAPH2	RLSSILFKLTFEEHINNIKPsIIAVTLACEELKKSESFNRL
Q17R91	T66	PSP	DIAPH2	IQIKTLADDVRDRITSFRKStVKKEKPLIQHPIDSQVAMSE
Q17R91	T882	PSP	DIAPH2	GFKINFLCKIRDTKSADQKTtLLHFIADICEEKYRDILKFP
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3KR16	S543	PSP	PLEKHG6	KRELLTLYRDQDREsPstRPstPsLEGSQSSAEGRTPEFST
Q3KR16	S546	PSP	PLEKHG6	LLTLYRDQDREsPstRPstPsLEGSQSSAEGRTPEFSTIIP
Q3KR16	S645	PSP	PLEKHG6	ELRDIPLRPHPPDPQAPQRRsAPELPEGILKGGSLPQEDPP
Q3KR16	S697	PSP	PLEKHG6	RGNVVVETLHRARLRGQLPSsPTHADSAGESPWESSGEEEE
Q3KR16	T540	PSP	PLEKHG6	VQQKRELLTLYRDQDREsPstRPstPsLEGSQSSAEGRTPE
Q3KR16	T544	SIGNOR\|PSP	PLEKHG6	RELLTLYRDQDREsPstRPstPsLEGSQSSAEGRTPEFSTI
Q3KR16	T620	PSP	PLEKHG6	GSRSPLSRLRQRALRRDPRLtFSTLELRDIPLRPHPPDPQA
Q53HL2	S154	EPSD\|PSP	CDCA8 PESCRG3	RKNLQTARVKRCPPSKKRTQsIQGKGKGKRSsRANtVTPAV
Q53HL2	S165	EPSD\|PSP	CDCA8 PESCRG3	CPPSKKRTQsIQGKGKGKRSsRANtVTPAVGRLEVSMVKPT
Q53HL2	S219	EPSD\|PSP	CDCA8 PESCRG3	tPGLRtPAAGERIyNIsGNGsPLADsKEIFLtVPVGGGEsL
Q53HL2	S275	EPSD\|PSP	CDCA8 PESCRG3	DPEALGNIKKLSNRLAQICSsIRtHK_______________
Q53HL2	T278	EPSD\|PSP	CDCA8 PESCRG3	ALGNIKKLSNRLAQICSsIRtHK__________________
Q53SF7	S876	PSP	COBLL1 KIAA0977	RASNAQAKPSSFFLQMQKRVsGHYVTSAAAKSVHAAPNPAP
Q5JQF8	S87	Sugiyama	PABPC1L2A PABPC1L2 RBM32A; PABPC1L2B PABPC1L2 RBM32B	VIKGRPVRIMWSQRDPsLRKsGVGNVFIKNLGKTIDNKALY
Q5QNW6	S37	Sugiyama	H2BC18 HIST2H2BF	KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6	S39	Sugiyama	H2BC18 HIST2H2BF	VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5QNW6	S79	EPSD	H2BC18 HIST2H2BF	AMGIMNsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAV
Q5QNW6	Y38	Sugiyama	H2BC18 HIST2H2BF	AVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q5QNW6	Y84	EPSD	H2BC18 HIST2H2BF	NsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAVRLLLP
Q5T0N5	S488	Sugiyama	FNBP1L C1orf39 TOCA1	NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD
Q5T1M5	S1162	Sugiyama	FKBP15 KIAA0674	EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5T1R4	S1680	Sugiyama	HIVEP3 KBP1 KIAA1555 KRC ZAS3	ETYTMATAPHPEAGRLVPsSsRKPRMTEVHLPSLVSPEGQK
Q5T5C0	S692	Sugiyama	STXBP5 LLGL3	YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q5T5U3	S131	PSP	ARHGAP21 ARHGAP10 KIAA1424	GPAFEAGLCTGDRIIKVNGEsVIGKTYSQVIALIQNSDTTL
Q5UIP0	S2205	EPSD\|PSP	RIF1	GLKRsQEDEIssPVNKVRRVsFADPIYQAGLADDIDRRCSI
Q5VTE0	T432	Sugiyama	EEF1A1P5 EEF1AL3	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q69YH5	S542	SIGNOR	CDCA2	CNLLNTEVQPCKEKKINRRKsQETKCTKRALPKKSQVLKSC
Q69YH5	S893	EPSD\|PSP	CDCA2	LSDAIEQTFQRRNSETKVRRsTRLQKDLENEGLVWISLPLP
Q69YH5	S977	SIGNOR\|PSP	CDCA2	PENsQGPAAGSSDEPGKRRKsFCIsTLANTKATSQFKGYRR
Q69YH5	S981	SIGNOR\|PSP	CDCA2	QGPAAGSSDEPGKRRKsFCIsTLANTKATSQFKGYRRRSsL
Q6DN03	S79	EPSD	H2BC20P HIST2H2BC	AMGIMNSFLNDIFERIAGEAsRLAHyNKRSTITSRRSRRPC
Q6DN03	Y84	EPSD	H2BC20P HIST2H2BC	NSFLNDIFERIAGEAsRLAHyNKRSTITSRRSRRPCACCCP
Q6DRA6	S79	EPSD	H2BC19P HIST2H2BD	AMGIMNSFLNDIFERIAGEAsRLAHyNKRSTITSRRSRRPC
Q6DRA6	Y84	EPSD	H2BC19P HIST2H2BD	NSFLNDIFERIAGEAsRLAHyNKRSTITSRRSRRPCACCCP
Q6L8Q7	S98	Sugiyama	PDE12	IATNALKGHAKAAAAKKSRKsRPNAsGGAACSGPGPEPAVF
Q6NZI2	S300	EPSD\|PSP	CAVIN1 PTRF FKSG13	RLVPAERREKLKTSRDKLRKsFtPDHVVyARSKTAVyKVPP
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71DI3	S11	EPSD	H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D	__________MARtKQTARKsTGGKAPRKQLATKAARKsAP
Q71DI3	S29	EPSD	H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D	RKsTGGKAPRKQLATKAARKsAPATGGVKKPHRyRPGtVAL
Q71UM5	T74	Sugiyama	RPS27L	VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q7KZF4	S150	Sugiyama	SND1 TDRD11	EGLAtRREGMRANNPEQNRLsECEEQAKAAKKGMWSEGNGS
Q7Z4V5	S454	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q7Z5L9	S457	Sugiyama	IRF2BP2	GSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVGGQ
Q86V81	S142	Sugiyama	ALYREF ALY BEF THOC4	IQELFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKA
Q86V81	S145	Sugiyama	ALYREF ALY BEF THOC4	LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IVT2	S348	EPSD\|PSP	MISP C19orf21	RPLLTKLSLItAPRRERGRPsLYVQRDIVQETQREEDHRRE
Q8IX03	S539	SIGNOR\|EPSD\|PSP	WWC1 KIAA0869 KIBRA	QALRsLSGtPKSMTSLsPRSsLSsPSPPCsPLMADPLLAGD
Q8IX90	S159	SIGNOR	SKA3 C13orf3 RAMA1	sDPPVASSCISEKsPRsPQLsDFGLERYIVSQVLPNPPQAV
Q8IZ21	S117	Sugiyama	PHACTR4 PRO2963	KPSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIP
Q8N142	S449	Sugiyama	ADSS1 ADSSL1	YIRFVENHVGVAVKWVGVGKsREsMIQLF____________
Q8N142	S452	Sugiyama	ADSS1 ADSSL1	FVENHVGVAVKWVGVGKsREsMIQLF_______________
Q8NBJ5	S607	Sugiyama	COLGALT1 GLT25D1 PSEC0241	DRAKSQKMREQQALSREAKNsDVLQsPLDsAARDEL_____
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NEM2	S634	SIGNOR\|EPSD\|PSP	SHCBP1	IVNELIAAStQKGQIKKKRLsELGITQADDNLMSQEMFVGI
Q8NEY8	S110	EPSD\|PSP	PPHLN1 HSPC206 HSPC232	DHsASRQPEYRDMRDGFRRKsFYsSHYARERSPYKRDNtFF
Q8NG31	S24	SIGNOR\|EPSD\|PSP	KNL1 CASC5 KIAA1570	VSSEANEENDNIERPVRRRHsSILKPPRsPLQDLRGGNERV
Q8NG31	S60	SIGNOR\|EPSD\|PSP	KNL1 CASC5 KIAA1570	GNERVQESNALRNKKNSRRVsFADTIKVFQTESHMKIVRKS
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TCS8	S767	Sugiyama	PNPT1 PNPASE	LSRKVLQsPAtTVVRTLNDRssIVMGEPIsQSSSNsQ____
Q8TD47	T247	Sugiyama	RPS4Y2 RPS4Y2P	VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8TE77	S37	EPSD\|PSP	SSH3 SSH3L	tPVGPWDQAVQRRSRLQRRQsFAVLRGAVLGLQDGGDNDDA
Q8TEW0	S962	EPSD\|PSP\|Sugiyama	PARD3 PAR3 PAR3A	DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ
Q8TEW0	Y719	Sugiyama	PARD3 PAR3 PAR3A	PELPIETALDDRERRIsHsLysGIEGLDEsPsRNAALsRIM
Q8TF76	S108	SIGNOR\|PSP	HASPIN GSG2	PKDRPsLTVtPKRWKLRARPsLtVtPRRLGLRARPPQKCSt
Q8TF76	S143	SIGNOR\|EPSD\|PSP	HASPIN GSG2	PQKCStPCGPLRLPPFPsRDsGRLsPDLsVCGQPRDGDELG
Q8TF76	S4	PSP	HASPIN GSG2	_________________MAAsLPGPGsRLFRtyGAADGRRQ
Q8TF76	S93	SIGNOR\|EPSD\|PSP	HASPIN GSG2	GSPVRRRRRRPGGRVPKDRPsLTVtPKRWKLRARPsLtVtP
Q8WWI1	S300	EPSD\|PSP	LMO7 FBX20 FBXO20 KIAA0858	sEFTFKMQDYNKDDMsYRRIsAVEPKTALPFNRFLPNKSRQ
Q8WWI1	S751	EPSD\|PSP	LMO7 FBX20 FBXO20 KIAA0858	LKEQDQKWQDDLAKWKDRRKsYtSDLQKKKEEREEIEKQAL
Q8WWK9	S628	SIGNOR\|EPSD\|PSP	CKAP2 LB1 TMAP	QFDGTNsAFKELKFLtPVRRsRRLQEKTSKLPDMLKDHyPC
Q8WWK9	T39	EPSD\|PSP	CKAP2 LB1 TMAP	QSAFKEQRRQKLKEHLLRRKtLFAYKQENEMLSSSRDQRVV
Q8WWM7	S500	Sugiyama	ATXN2L A2D A2LG A2LP A2RP	VTSSVSDPGVGsIsPAsPKIsLAPTDVKELSTKEPGRTLEP
Q8WYJ6	S253	PSP	SEPTIN1 DIFF6 PNUTL3 SEPT1	VGSCEVVRDGGNRPVRGRRYsWGTVEVENPHHCDFLNLRRM
Q8WYJ6	S312	PSP	SEPTIN1 DIFF6 PNUTL3 SEPT1	EGYRARCLQSLARPGARDRAsRSKLSRQsATEIPLPMLPLA
Q8WYJ6	S320	PSP	SEPTIN1 DIFF6 PNUTL3 SEPT1	QSLARPGARDRAsRSKLSRQsATEIPLPMLPLADTEKLIRE
Q92538	S174	EPSD\|PSP	GBF1 KIAA0248	NESVCEIMQSCFRICFEMRLsELLRKSAEHTLVDMVQLLFT
Q92766	S1167	Sugiyama	RREB1 FINB	AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q92945	S333	Sugiyama	KHSRP FUBP2	DRNEyGsRIGGGIDVPVPRHsVGVVIGRSGEMIKKIQNDAG
Q92974	S960	SIGNOR	ARHGEF2 KIAA0651 LFP40	ssDPDtGsEEEGssRLsPPHsPRDFtRMQDIPEEtEsRDGE
Q92995	S114	PSP	USP13 ISOT3	RHVREKVRGAsGGALPKRRNsKIFLDLDtDDDLNsDDYEYE
Q93079	S37	Sugiyama	H2BC9 H2BFJ HIST1H2BH	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079	S39	Sugiyama	H2BC9 H2BFJ HIST1H2BH	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q93079	S79	EPSD	H2BC9 H2BFJ HIST1H2BH	AMGIMNsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAV
Q93079	Y38	Sugiyama	H2BC9 H2BFJ HIST1H2BH	AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q93079	Y84	EPSD	H2BC9 H2BFJ HIST1H2BH	NsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAVRLLLP
Q96CF2	S210	SIGNOR\|EPSD\|PSP	CHMP4C SHAX3	SSsLPAQPNRKPGMSSTARRsRAAssQRAEEEDDDIKQLAA
Q96CF2	S214	SIGNOR\|EPSD\|PSP	CHMP4C SHAX3	PAQPNRKPGMSSTARRsRAAssQRAEEEDDDIKQLAAWAT_
Q96CF2	S215	SIGNOR\|EPSD\|PSP	CHMP4C SHAX3	AQPNRKPGMSSTARRsRAAssQRAEEEDDDIKQLAAWAT__
Q96CV9	S526	Sugiyama	OPTN FIP2 GLC1E HIP7 HYPL NRP	FEDGGRQsLMEMQsRHGARtsDsDQQAyLVQRGAEDRDWRQ
Q96D15	S117	Sugiyama	RCN3 UNQ239/PRO272	VsLAELRAWIAHTQQRHIRDsVsAAWDtyDtDRDGRVGWEE
Q96D46	S462	Sugiyama	NMD3 CGI-07	FLEDLEEDEAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAE
Q96E39	S326	EPSD\|PSP	RBMXL1	GssRYDDysssRDGyGGsRDsYsssRsDLySsCDRVGRQER
Q96FF9	S126	SIGNOR\|EPSD\|PSP	CDCA5	HsVPAtPtstPVPNPEAEsssKEGELDARDLEMsKKVRRsY
Q96FF9	S139	SIGNOR\|EPSD\|PSP	CDCA5	NPEAEsssKEGELDARDLEMsKKVRRsYsRLEtLGsAstst
Q96FF9	S164	SIGNOR\|EPSD\|PSP	CDCA5	RsYsRLEtLGsAststPGRRsCFGFEGLLGAEDLSGVsPVV
Q96FF9	S33	SIGNOR\|EPSD\|PSP	CDCA5	QRSGPRAPsPtKPLRRsQRKsGsELPSILPEIWPKtPSAAA
Q96FF9	S79	EPSD\|PSP	CDCA5	VLKRIVAHAVEVPAVQsPRRsPRIsFFLEKENEPPGRELTK
Q96FF9	S83	SIGNOR\|EPSD\|PSP	CDCA5	IVAHAVEVPAVQsPRRsPRIsFFLEKENEPPGRELTKEDLF
Q96FF9	T111	EPSD\|PSP	CDCA5	EPPGRELTKEDLFKtHsVPAtPtstPVPNPEAEsssKEGEL
Q96FF9	T115	EPSD\|PSP	CDCA5	RELTKEDLFKtHsVPAtPtstPVPNPEAEsssKEGELDARD
Q96FF9	T151	SIGNOR\|EPSD\|PSP	CDCA5	LDARDLEMsKKVRRsYsRLEtLGsAststPGRRsCFGFEGL
Q96FF9	T159	EPSD\|PSP	CDCA5	sKKVRRsYsRLEtLGsAststPGRRsCFGFEGLLGAEDLSG
Q96G46	T240	Sugiyama	DUS3L	KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96GD4	S19	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	__MAQKENsyPWPYGRQtAPsGLsTLPQRVLRKEPVtPsAL
Q96GD4	S22	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	AQKENsyPWPYGRQtAPsGLsTLPQRVLRKEPVtPsALVLM
Q96GD4	S37	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	APsGLsTLPQRVLRKEPVtPsALVLMsRsNVQPTAAPGQKV
Q96GD4	S43	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	TLPQRVLRKEPVtPsALVLMsRsNVQPTAAPGQKVMENssG
Q96GD4	S45	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	PQRVLRKEPVtPsALVLMsRsNVQPTAAPGQKVMENssGtP
Q96GD4	S61	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	LMsRsNVQPTAAPGQKVMENssGtPDILTRHFtIDDFEIGR
Q96GD4	S62	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	MsRsNVQPTAAPGQKVMENssGtPDILTRHFtIDDFEIGRP
Q96GD4	S7	EPSD\|PSP\|Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	______________MAQKENsyPWPYGRQtAPsGLsTLPQR
Q96GD4	T16	EPSD\|PSP\|Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	_____MAQKENsyPWPYGRQtAPsGLsTLPQRVLRKEPVtP
Q96GD4	T232	SIGNOR\|ELM\|EPSD\|PSP\|Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	GELKIADFGWSVHAPsLRRKtMCGtLDYLPPEMIEGRMHNE
Q96GD4	T236	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	IADFGWSVHAPsLRRKtMCGtLDYLPPEMIEGRMHNEKVDL
Q96GD4	T35	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	QtAPsGLsTLPQRVLRKEPVtPsALVLMsRsNVQPTAAPGQ
Q96GD4	T64	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	RsNVQPTAAPGQKVMENssGtPDILTRHFtIDDFEIGRPLG
Q96GD4	Y8	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	_____________MAQKENsyPWPYGRQtAPsGLsTLPQRV
Q96GD4	Y92	Sugiyama	AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	FtIDDFEIGRPLGKGKFGNVyLAREKKSHFIVALKVLFKSQ
Q96K21	S22	PSP	ZFYVE19 ANCHR MPFYVE	NYDSQQPPLPPLPYAGCRRAsGFPALGRGGTVPVGVWGGAG
Q96PK6	S618	EPSD\|PSP	RBM14 SIP	MSKRYGSDRRLAELsDYRRLsEsQLsFRRsPtKSSLDYRRL
Q96PK6	S649	EPSD\|PSP	RBM14 SIP	tKSSLDYRRLPDAHsDyARYsGsYNDyLRAAQMHSGYQRRM
Q96RU3	S497	Sugiyama	FNBP1 FBP17 KIAA0554	AWLAEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREs
Q99661	S109	EPSD\|PSP	KIF2C KNSL6	QKQKRRsVNSKIPAPKEsLRsRsTRMstVSELRITAQENDM
Q99661	S111	SIGNOR\|EPSD\|PSP	KIF2C KNSL6	QKRRsVNSKIPAPKEsLRsRsTRMstVSELRITAQENDMEV
Q99661	S115	EPSD\|PSP	KIF2C KNSL6	sVNSKIPAPKEsLRsRsTRMstVSELRITAQENDMEVELPA
Q99661	S192	SIGNOR\|EPSD\|PSP	KIF2C KNSL6	QVHsIRGsssANPVNsVRRKsCLVKEVEKMKNKREEKKAQN
Q99661	S95	SIGNOR\|ELM\|EPSD\|PSP	KIF2C KNSL6	HPKDNLPLQENVtIQKQKRRsVNSKIPAPKEsLRsRsTRMs
Q99755	S475	Sugiyama	PIP5K1A	LKPsPsKKFRSGssFSRRAGssGNsCItyQPsVsGEHKAQV
Q99848	S264	Sugiyama	EBNA1BP2 EBP2	KNQKFGFGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRP
Q99877	S37	Sugiyama	H2BC15 H2BFD HIST1H2BN	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877	S39	Sugiyama	H2BC15 H2BFD HIST1H2BN	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99877	S79	EPSD	H2BC15 H2BFD HIST1H2BN	AMGIMNsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAV
Q99877	Y38	Sugiyama	H2BC15 H2BFD HIST1H2BN	AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99877	Y84	EPSD	H2BC15 H2BFD HIST1H2BN	NsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAVRLLLP
Q99879	S37	Sugiyama	H2BC14 H2BFE HIST1H2BM	KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879	S39	Sugiyama	H2BC14 H2BFE HIST1H2BM	INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879	S79	EPSD	H2BC14 H2BFE HIST1H2BM	AMGIMNsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAV
Q99879	Y38	Sugiyama	H2BC14 H2BFE HIST1H2BM	AINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q99879	Y84	EPSD	H2BC14 H2BFE HIST1H2BM	NsFVNDIFERIAGEAsRLAHyNKRStItsREIQTAVRLLLP
Q99880	S37	Sugiyama	H2BC13 H2BFC HIST1H2BL	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880	S39	Sugiyama	H2BC13 H2BFC HIST1H2BL	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880	Y38	Sugiyama	H2BC13 H2BFC HIST1H2BL	AVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssK
Q9BQG0	S1303	SIGNOR\|EPSD\|PSP	MYBBP1A P160	KKGVLGKsPLsALARKKARLsLVIRSPsLLQSGAKKKAQVR
Q9BRK5	S99	Sugiyama	SDF4 CAB45 PSEC0034	QEVFLGKDLGGFDEDAEPRRsRRKLMVIFSKVDVNTDRKIS
Q9BW61	S33	EPSD\|PSP	DDA1 C19orf58 PCIA1	KSNFSRFHADSVCKASNRRPsVYLPTREYPSEQIIVTEKTN
Q9BXS6	S240	EPSD\|PSP	NUSAP1 ANKT BM-037 PRO0310	KQQPINKGGVRTPVPPRGRLsVAstPIsQRRsQGRsCGPAs
Q9C0C2	S936	Sugiyama	TNKS1BP1 KIAA1741 TAB182	GRyssQDADEQDWEFQKRDVsLGTyGSRAAEPQEQEFGKSA
Q9GZT3	S15	Sugiyama	SLIRP C14orf156 DC23 DC50 PD04872	______MAASAARGAAALRRsINQPVAFVRRIPWTAASSQL
Q9H008	S241	Sugiyama	LHPP	GGAQRCGMRALQVRTGKFRPsDEHHPEVKADGYVDNLAEAV
Q9H0B6	S428	Sugiyama	KLC2	NKPIWMHAEEREESKDKRRDsAPyGEyGsWYKACKVDsPtV
Q9H0H5	S144	SIGNOR\|iPTMNet	RACGAP1 KIAA1478 MGCRACGAP	ALAFLNRGQPSSSNAGNKRLstIDEsGsILsDIsFDKtDEs
Q9H0H5	S185	SIGNOR\|iPTMNet	RACGAP1 KIAA1478 MGCRACGAP	LDWDssLVKTFKLKKREKRRstsRQFVDGPPGPVKKtRsIG
Q9H0H5	S187	SIGNOR\|iPTMNet	RACGAP1 KIAA1478 MGCRACGAP	WDssLVKTFKLKKREKRRstsRQFVDGPPGPVKKtRsIGsA
Q9H0H5	S387	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RACGAP1 KIAA1478 MGCRACGAP	VHCVNEIEQRGLTETGLyRIsGCDRTVKELKEKFLRVKTVP
Q9H0H5	S410	ELM\|iPTMNet\|EPSD	RACGAP1 KIAA1478 MGCRACGAP	DRTVKELKEKFLRVKTVPLLsKVDDIHAICSLLKDFLRNLK
Q9H0H5	T145	SIGNOR\|iPTMNet	RACGAP1 KIAA1478 MGCRACGAP	LAFLNRGQPSSSNAGNKRLstIDEsGsILsDIsFDKtDEsL
Q9H0H5	T186	SIGNOR\|iPTMNet	RACGAP1 KIAA1478 MGCRACGAP	DWDssLVKTFKLKKREKRRstsRQFVDGPPGPVKKtRsIGs
Q9H0H5	T249	EPSD\|PSP	RACGAP1 KIAA1478 MGCRACGAP	PIEAVSTIETVPYWtRSRRKtGtLQPWNsDstLNSRQLEPR
Q9H211	S143	PSP	CDT1	LASCLQRARELGARVRALKAsAQDAGEsCtPEAEGRPEEPC
Q9H211	T102	PSP	CDT1	tPEAPDIPACPsPGQKIKKStPAAGQPPHLTSAQDQDTISE
Q9H211	T358	PSP	CDT1	DEVPDIEPAALPQPPATEKLtTAQEVLARARNLIsPRMEKA
Q9H211	T7	PSP	CDT1	______________MEQRRVtDFFARRRPGPPRIAPPKLAC
Q9H3N1	S270	Sugiyama	TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268	EAEsKEGtNKDFPQNAIRQRsLGPsLAtDKs__________
Q9H3Q1	S309	Sugiyama	CDC42EP4 BORG4 CEP4	AAPsPGsARSMGSHTTRDSSsLssCtsGILEERsPAFRGPD
Q9H410	S100	SIGNOR\|EPSD\|PSP	DSN1 C20orf172 MIS13	LsPQEQsAsYQDRRQSWRRAsMKETNRRKsLHPIHQGITEL
Q9H410	S109	SIGNOR\|EPSD\|PSP	DSN1 C20orf172 MIS13	YQDRRQSWRRAsMKETNRRKsLHPIHQGITELSRsIsVDLA
Q9H6F5	S255	EPSD\|PSP	CCDC86 CYCLON	IPKGKPKSGRVWKDRSKKRFsQMLQDKPLRTSWQRKMKERQ
Q9H788	S261	EPSD\|PSP	SH2D4A PPP1R38 SH2A	AADEKRRSLAKQAREDYKRLsLGAQKGRGGERLQsPLRVPQ
Q9H7D7	S121	Sugiyama	WDR26 CDW2 MIP2 PRO0852	ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9H7D7	S123	Sugiyama	WDR26 CDW2 MIP2 PRO0852	SSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLNQT
Q9H814	T151	Sugiyama	PHAX RNUXA	ATELGILGMEGTIDRsRQsEtyNyLLAKKLRKESQEHTKDL
Q9HA77	S544	Sugiyama	CARS2 OK/SW-cl.10	EACDTLRRGLTAHGINIKDRssttstWELLDQRTKDQKSAG
Q9NP77	S19	SIGNOR\|EPSD\|PSP	SSU72 HSPC182 PNAS-120	__MPssPLRVAVVCSSNQNRsMEAHNILSKRGFSVRSFGTG
Q9NP77	S3	PSP	SSU72 HSPC182 PNAS-120	__________________MPssPLRVAVVCSSNQNRsMEAH
Q9NP77	S4	PSP	SSU72 HSPC182 PNAS-120	_________________MPssPLRVAVVCSSNQNRsMEAHN
Q9NQG5	S145	SIGNOR\|PSP	RPRD1B C20orf77 CREPT	LKLSMEDsKsPPPKATEEKKsLKRTFQQIQEEEDDDyPGsy
Q9NQS7	S518	EPSD\|PSP	INCENP	tVQRNQMLMtPtsAPRSVMKsFIKRNTPLRMDPKCSFVEKE
Q9NQS7	S72	EPSD\|PSP	INCENP	EPELMPKtPSQKNRRKKRRIsYVQDENRDPIRRRLSRRKsR
Q9NQS7	S828	Sugiyama	INCENP	PQGHRAPPKINPDNYGMDLNsDDstDDEAHPRKPIPTWARG
Q9NQS7	S831	Sugiyama	INCENP	HRAPPKINPDNYGMDLNsDDstDDEAHPRKPIPTWARGTPL
Q9NQS7	S893	SIGNOR\|EPSD\|PSP	INCENP	LPLDLEDIFKKSKPRYHKRtssAVWNsPPLQGARVPssLAY
Q9NQS7	S894	SIGNOR\|EPSD\|PSP\|Sugiyama	INCENP	PLDLEDIFKKSKPRYHKRtssAVWNsPPLQGARVPssLAYs
Q9NQS7	S899	ELM\|EPSD\|PSP\|Sugiyama	INCENP	DIFKKSKPRYHKRtssAVWNsPPLQGARVPssLAYsLKKH_
Q9NQS7	S909	Sugiyama	INCENP	HKRtssAVWNsPPLQGARVPssLAYsLKKH___________
Q9NQS7	S910	Sugiyama	INCENP	KRtssAVWNsPPLQGARVPssLAYsLKKH____________
Q9NQS7	S914	Sugiyama	INCENP	sAVWNsPPLQGARVPssLAYsLKKH________________
Q9NQS7	T494	EPSD\|PSP	INCENP	PRsKtPSsPCPASKVVRPLRtFLHtVQRNQMLMtPtsAPRS
Q9NQS7	T59	EPSD\|PSP	INCENP	EEAERMFTREFSKEPELMPKtPSQKNRRKKRRIsYVQDENR
Q9NQS7	T832	Sugiyama	INCENP	RAPPKINPDNYGMDLNsDDstDDEAHPRKPIPTWARGTPLS
Q9NQS7	T892	SIGNOR\|EPSD\|PSP\|Sugiyama	INCENP	ILPLDLEDIFKKSKPRYHKRtssAVWNsPPLQGARVPssLA
Q9NQZ2	S462	EPSD\|PSP	UTP3 CRLZ1 SAS10	RAKIRRRGQVREVRKEEQRYsGELsGIRAGVKKSIKLK___
Q9NRA8	S353	Sugiyama	EIF4ENIF1	SASRFSRWFSNPsRsGsRsssLGstPHEELERLAGLEQAIL
Q9NRF8	S568	Sugiyama	CTPS2	TGNLNAYLQQGCKLsssDRysDAsDDsFSEPRIAELEIS__
Q9NRL2	S1363	Sugiyama	BAZ1A ACF1 WCRF180 HSPC317	LQADVFVELLsPRRKRRGRKsANNtPENsPNFPNFRVIATK
Q9NS23	S207	SIGNOR	RASSF1 RDA32	PsLQDARRGPGRGTSVRRRtsFYLPKDAVKHLHVLSRTRAR
Q9NYF8	S319	Sugiyama	BCLAF1 BTF KIAA0164	RsPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKR
Q9NYF8	S320	Sugiyama	BCLAF1 BTF KIAA0164	sPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRF
Q9NYP9	S36	EPSD\|PSP	MIS18A C21orf45 C21orf46 FASP1	GCECGDKGKCsDssLLGKRLsEDssRHQLLQKWASMWSSMS
Q9NZL9	S9	Sugiyama	MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995	____________MVGREKELsIHFVPGsCRLVEEEVNIPNR
Q9NZN8	S242	Sugiyama	CNOT2 CDC36 NOT2 HSPC131 MSTP046	VTGLDLSDFPALADRNRREGsGNPtPLINPLAGRAPYVGMV
Q9P227	S127	EPSD\|PSP	ARHGAP23 KIAA1501	GPAHRAGLRTGDRLVKVNGEsVIGKTYSQVIALIQNSDDTL
Q9P287	S12	Sugiyama	BCCIP TOK1	_________MASRSKRRAVEsGVPQPPDPPVQRDEEEEKEV
Q9UBB4	S12	EPSD\|PSP	ATXN10 SCA10	_________MAAPRPPPARLsGVMVPAPIQDLEALRALTAL
Q9UGV2	S334	Sugiyama	NDRG3	GYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDG
Q9UGV2	S335	Sugiyama	NDRG3	YIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDGt
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UI15	T190	Sugiyama	TAGLN3 NP25	GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9UI15	Y192	Sugiyama	TAGLN3 NP25	NVIGLQMGSNKGAsQAGMtGyGMPRQIM_____________
Q9UJ70	S76	EPSD\|PSP	NAGK	AKRKAGVDPLVPLRsLGLsLsGGDQEDAGRILIEELRDRFP
Q9UKV0	S239	SIGNOR	HDAC9 HDAC7 HDAC7B HDRP KIAA0744 MITR	AsEPNLKVRSRLKQKVAERRssPLLRRKDGNVVTsFKKRMF
Q9UKV3	S240	Sugiyama	ACIN1 ACINUS KIAA0670	KPRKGERRSSRVRQARAAKLsEGsQPAEEEEDQEtPsRNLR
Q9UKX7	S52	Sugiyama	NUP50 NPAP60L PRO1146	EEVLKNRAIKKAKRRNVGFEsDtGGAFKGFKGLVVPSGGGR
Q9ULD2	S1224	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	tEQAVLQESLEKESKVNKRLsMENEELLWKLHNGDLCsPKR
Q9ULD2	S1259	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	LCsPKRsPtssAIPLQsPRNsGsFPsPsIsPR_________
Q9UNZ2	S74	Sugiyama	NSFL1C UBXN2C	SQATPssVsRGTAPSDNRVtsFRDLIHDQDEDEEEEEGQRF
Q9UPQ0	S177	Sugiyama	LIMCH1 KIAA1102	LAQMRKDTDDIEsPKRSIRDsGyIDCWDsERsDsLsPPRHG
Q9UPY8	S176	SIGNOR\|EPSD\|PSP	MAPRE3	AVPQRtsPtGPKNMQTSGRLsNVAPPCILRKNPPSARNGGH
Q9UQ35	S1099	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sHsEsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRG
Q9UQ35	S1101	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sEsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEF
Q9UQ35	S1539	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35	S2692	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQB9	T198	Sugiyama	AURKC AIE2 AIK3 AIRK3 ARK3 STK13	GEVKIADFGWSVHTPSLRRKtMCGtLDYLPPEMIEGRTYDE
Q9UQB9	T202	Sugiyama	AURKC AIE2 AIK3 AIRK3 ARK3 STK13	IADFGWSVHTPSLRRKtMCGtLDYLPPEMIEGRTYDEKVDL
Q9UQB9	Y58	Sugiyama	AURKC AIE2 AIK3 AIRK3 ARK3 STK13	LTVDDFEIGRPLGKGKFGNVyLARLKESHFIVALKVLFKSQ
Q9UQL6	S278	SIGNOR\|EPSD\|PSP	HDAC5 KIAA0600	AsEPNLKVRSRLKQKVAERRssPLLRRKDGTVIStFKKRAV
Q9Y230	S43	Sugiyama	RUVBL2 INO80J TIP48 TIP49B CGI-46	GAHSHIRGLGLDDALEPRQAsQGMVGQLAARRAAGVVLEMI
Q9Y266	T40	EPSD\|PSP	NUDC	QHEGGVQELVNTFFSFLRRKtDFFIGGEEGMAEKLItQTFs
Q9Y2B0	S115	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2I6	S185	SIGNOR\|EPSD\|PSP	NINL KIAA0980 NLP	QNELFEAQGQLQTWDSEDFGsPQKSCsPSFDTPESQIRGVW
Q9Y2I6	S448	SIGNOR\|EPSD\|PSP	NINL KIAA0980 NLP	LEQLTEKKIKHLEQGYRERLsLLRSEVEAERELFWEQAHRQ
Q9Y2I6	S585	SIGNOR\|EPSD\|PSP	NINL KIAA0980 NLP	NDELQAELEGLWARLPKNRHsPSWsPDGRRRQLPGLGPAGI
Q9Y2R4	S22	EPSD\|PSP	DDX52 ROK1 HUSSY-19	DVHDLFRRLGAGAKFDTRRFsADAARFQIGKRKYDFDSSEV
Q9Y3U8	S91	Sugiyama	RPL36	KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y520	S1013	EPSD\|PSP	PRRC2C BAT2D1 BAT2L2 KIAA1096 XTP2	WGPRPSSNRREEVNDRPVRRsGPIKKPVLRDMKEEREQRKE
Q9Y5B9	T494	EPSD\|PSP	SUPT16H FACT140 FACTP140	RRAHQKELAAQLNEEAKRRLtEQKGEQQIQKARKSNVSYKN
Q9Y6D5	S277	Sugiyama	ARFGEF2 ARFGEP2 BIG2	RSDSGKVSTENGDAPRERGssLsGtDDGAQEVVKDILEDVV

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
NRAGE signals death through JNK	R-HSA-193648	7.410771e-07	6.130	0	0
Cell Cycle	R-HSA-1640170	1.710400e-06	5.767	1	0
G alpha (12/13) signalling events	R-HSA-416482	2.350884e-06	5.629	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.702473e-06	5.568	0	0
Signal Transduction	R-HSA-162582	5.114535e-06	5.291	1	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.904568e-06	5.229	0	0
Cell Cycle Checkpoints	R-HSA-69620	1.730744e-05	4.762	1	0
Axon guidance	R-HSA-422475	1.588844e-05	4.799	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	1.641026e-05	4.785	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	3.027636e-05	4.519	0	0
Nervous system development	R-HSA-9675108	3.640471e-05	4.439	0	0
Chromatin modifying enzymes	R-HSA-3247509	5.194326e-05	4.284	0	0
Death Receptor Signaling	R-HSA-73887	6.883851e-05	4.162	0	0
PKMTs methylate histone lysines	R-HSA-3214841	9.516096e-05	4.022	0	0
Chromatin organization	R-HSA-4839726	1.291971e-04	3.889	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.347368e-04	3.871	0	0
Apoptotic execution phase	R-HSA-75153	1.387290e-04	3.858	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.329562e-04	3.633	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.592614e-04	3.586	0	0
Cell Cycle, Mitotic	R-HSA-69278	3.352650e-04	3.475	1	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.134073e-04	3.384	1	1
Amplification of signal from the kinetochores	R-HSA-141424	4.134073e-04	3.384	1	0
Oncogenic MAPK signaling	R-HSA-6802957	3.535830e-04	3.452	0	0
Rap1 signalling	R-HSA-392517	4.157221e-04	3.381	0	0
Signaling by ROBO receptors	R-HSA-376176	3.994585e-04	3.399	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	5.798289e-04	3.237	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	6.185945e-04	3.209	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	6.413092e-04	3.193	0	0
Activation of RAC1	R-HSA-428540	9.583104e-04	3.018	0	0
Sema4D in semaphorin signaling	R-HSA-400685	1.002661e-03	2.999	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	1.019410e-03	2.992	1	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.071788e-03	2.970	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	1.349357e-03	2.870	0	0
Semaphorin interactions	R-HSA-373755	1.459344e-03	2.836	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	1.560210e-03	2.807	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.001201e-03	2.699	0	0
Cellular Senescence	R-HSA-2559583	2.222787e-03	2.653	0	0
Mitotic Prometaphase	R-HSA-68877	2.408057e-03	2.618	1	1
Regulation of TP53 Activity	R-HSA-5633007	2.897635e-03	2.538	1	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.618154e-03	2.442	0	0
mRNA Splicing	R-HSA-72172	3.881354e-03	2.411	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	4.389250e-03	2.358	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.408346e-03	2.356	1	1
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	4.371669e-03	2.359	1	1
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.872842e-03	2.312	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	6.222499e-03	2.206	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	6.253356e-03	2.204	1	1
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	6.717703e-03	2.173	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	7.066297e-03	2.151	0	0
Neurodegenerative Diseases	R-HSA-8863678	7.066297e-03	2.151	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	8.462947e-03	2.072	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	8.462947e-03	2.072	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	8.462947e-03	2.072	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	8.462947e-03	2.072	0	0
HDMs demethylate histones	R-HSA-3214842	8.753727e-03	2.058	0	0
Interleukin-37 signaling	R-HSA-9008059	8.993209e-03	2.046	0	0
Netrin-1 signaling	R-HSA-373752	1.002176e-02	1.999	0	0
Kinesins	R-HSA-983189	9.752552e-03	2.011	0	0
TRP channels	R-HSA-3295583	1.073386e-02	1.969	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.071226e-02	1.970	0	0
Diseases of programmed cell death	R-HSA-9645723	1.063670e-02	1.973	0	0
FLT3 Signaling	R-HSA-9607240	1.220356e-02	1.914	0	0
RET signaling	R-HSA-8853659	1.266335e-02	1.897	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.347089e-02	1.871	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.347089e-02	1.871	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	1.347089e-02	1.871	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.278222e-02	1.893	0	0
Signaling by RAS mutants	R-HSA-6802949	1.347089e-02	1.871	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.355895e-02	1.868	0	0
Germ layer formation at gastrulation	R-HSA-9754189	1.503920e-02	1.823	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.487535e-02	1.828	0	0
mRNA 3'-end processing	R-HSA-72187	1.452920e-02	1.838	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.563299e-02	1.806	0	0
Meiotic synapsis	R-HSA-1221632	1.656935e-02	1.781	0	0
Epigenetic regulation of gene expression	R-HSA-212165	1.636080e-02	1.786	0	0
M Phase	R-HSA-68886	1.633490e-02	1.787	1	0
Muscle contraction	R-HSA-397014	1.655597e-02	1.781	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	1.782353e-02	1.749	1	0
Separation of Sister Chromatids	R-HSA-2467813	1.772979e-02	1.751	1	1
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.752549e-02	1.756	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.771210e-02	1.752	0	0
MAPK family signaling cascades	R-HSA-5683057	1.999039e-02	1.699	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	2.185794e-02	1.660	0	0
HATs acetylate histones	R-HSA-3214847	2.134685e-02	1.671	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	2.208611e-02	1.656	0	0
RAF/MAP kinase cascade	R-HSA-5673001	2.209870e-02	1.656	0	0
G2/M Transition	R-HSA-69275	2.301023e-02	1.638	0	0
Protein-protein interactions at synapses	R-HSA-6794362	2.348273e-02	1.629	0	0
Mitotic G2-G2/M phases	R-HSA-453274	2.610417e-02	1.583	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.586059e-02	1.587	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.873044e-02	1.542	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	2.873044e-02	1.542	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.873044e-02	1.542	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.873044e-02	1.542	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.873044e-02	1.542	0	0
Signaling by Hippo	R-HSA-2028269	2.747868e-02	1.561	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.770978e-02	1.557	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	2.774459e-02	1.557	0	0
Signaling by RAF1 mutants	R-HSA-9656223	3.055152e-02	1.515	0	0
MAP2K and MAPK activation	R-HSA-5674135	3.055152e-02	1.515	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.109664e-02	1.507	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	3.139605e-02	1.503	0	0
Regulation of KIT signaling	R-HSA-1433559	3.276537e-02	1.485	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	3.366063e-02	1.473	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	3.321110e-02	1.479	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	3.201241e-02	1.495	0	0
Ephrin signaling	R-HSA-3928664	3.366063e-02	1.473	0	0
Cardiac conduction	R-HSA-5576891	3.433270e-02	1.464	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.606503e-02	1.443	0	0
AURKA Activation by TPX2	R-HSA-8854518	3.781290e-02	1.422	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	3.762834e-02	1.424	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.750483e-02	1.426	0	0
Activation of ATR in response to replication stress	R-HSA-176187	3.524798e-02	1.453	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	3.781290e-02	1.422	0	0
G2/M Checkpoints	R-HSA-69481	3.778691e-02	1.423	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.752615e-02	1.426	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	3.785080e-02	1.422	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	3.848675e-02	1.415	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	4.076595e-02	1.390	0	0
Meiosis	R-HSA-1500620	4.096446e-02	1.388	0	0
Gene expression (Transcription)	R-HSA-74160	4.107404e-02	1.386	1	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.511137e-02	1.346	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.164498e-02	1.380	0	0
Dopamine receptors	R-HSA-390651	4.511137e-02	1.346	0	0
RNA Polymerase II Transcription	R-HSA-73857	4.377001e-02	1.359	1	0
MECP2 regulates transcription factors	R-HSA-9022707	4.370286e-02	1.359	0	0
G2/M DNA damage checkpoint	R-HSA-69473	4.567402e-02	1.340	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	4.902381e-02	1.310	0	0
RAF activation	R-HSA-5673000	4.647681e-02	1.333	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	4.647681e-02	1.333	0	0
Nucleosome assembly	R-HSA-774815	4.974035e-02	1.303	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.974035e-02	1.303	0	0
Centrosome maturation	R-HSA-380287	4.997298e-02	1.301	0	0
Prolonged ERK activation events	R-HSA-169893	4.990174e-02	1.302	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.602251e-02	1.337	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.678532e-02	1.330	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.633882e-02	1.334	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	4.602251e-02	1.337	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	5.074261e-02	1.295	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	5.369221e-02	1.270	0	0
Apoptosis	R-HSA-109581	5.416005e-02	1.266	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	5.939868e-02	1.226	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	5.939868e-02	1.226	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	5.795234e-02	1.237	0	0
Type I hemidesmosome assembly	R-HSA-446107	5.795234e-02	1.237	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	6.109824e-02	1.214	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	6.109824e-02	1.214	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	6.109824e-02	1.214	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	6.109824e-02	1.214	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	6.109824e-02	1.214	0	0
PRC2 methylates histones and DNA	R-HSA-212300	5.989517e-02	1.223	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.607203e-02	1.251	0	0
FOXO-mediated transcription	R-HSA-9614085	5.878782e-02	1.231	0	0
Neurexins and neuroligins	R-HSA-6794361	5.603821e-02	1.252	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	5.795234e-02	1.237	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	6.109824e-02	1.214	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	5.795234e-02	1.237	0	0
MITF-M-dependent gene expression	R-HSA-9856651	5.792794e-02	1.237	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	6.124178e-02	1.213	0	0
Drug resistance of KIT mutants	R-HSA-9669937	1.224865e-01	0.912	0	0
Drug resistance of PDGFR mutants	R-HSA-9674415	1.224865e-01	0.912	0	0
KIT mutants bind TKIs	R-HSA-9669921	1.224865e-01	0.912	0	0
PDGFR mutants bind TKIs	R-HSA-9674428	1.224865e-01	0.912	0	0
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.224865e-01	0.912	0	0
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.224865e-01	0.912	0	0
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.224865e-01	0.912	0	0
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.224865e-01	0.912	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.224865e-01	0.912	0	0
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.224865e-01	0.912	0	0
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.224865e-01	0.912	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.224865e-01	0.912	0	0
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.224865e-01	0.912	0	0
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.224865e-01	0.912	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.224865e-01	0.912	0	0
Masitinib-resistant KIT mutants	R-HSA-9669924	1.224865e-01	0.912	0	0
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.224865e-01	0.912	0	0
Imatinib-resistant KIT mutants	R-HSA-9669917	1.224865e-01	0.912	0	0
Regulation of TP53 Expression	R-HSA-6804754	9.712615e-02	1.013	0	0
Potassium transport channels	R-HSA-1296067	9.712615e-02	1.013	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.299763e-01	0.638	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.299763e-01	0.638	0	0
Tandem pore domain halothane-inhibited K+ channel (THIK)	R-HSA-1299287	2.299763e-01	0.638	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.299763e-01	0.638	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.299763e-01	0.638	0	0
Defective SLC26A4 causes Pendred syndrome (PDS)	R-HSA-5619046	2.299763e-01	0.638	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	6.524484e-02	1.185	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	6.524484e-02	1.185	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.397250e-01	0.855	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.397250e-01	0.855	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	8.876859e-02	1.052	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	8.876859e-02	1.052	0	0
Signaling by MAPK mutants	R-HSA-9652817	8.876859e-02	1.052	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	7.438102e-02	1.129	0	0
ARMS-mediated activation	R-HSA-170984	7.438102e-02	1.129	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	7.438102e-02	1.129	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.152863e-01	0.938	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	1.152863e-01	0.938	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.854372e-01	0.732	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.854372e-01	0.732	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.854372e-01	0.732	0	0
PI and PC transport between ER and Golgi membranes	R-HSA-1483196	3.243048e-01	0.489	0	0
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	3.243048e-01	0.489	0	0
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	3.243048e-01	0.489	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.243048e-01	0.489	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	3.243048e-01	0.489	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.243048e-01	0.489	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.243048e-01	0.489	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.243048e-01	0.489	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	3.243048e-01	0.489	0	0
Signaling by kinase domain mutants of KIT	R-HSA-9669933	3.243048e-01	0.489	0	0
MyD88 deficiency (TLR5)	R-HSA-5602680	3.243048e-01	0.489	0	0
Intestinal infectious diseases	R-HSA-8942233	3.243048e-01	0.489	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	3.243048e-01	0.489	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.243048e-01	0.489	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.443577e-01	0.841	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	1.443577e-01	0.841	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.443577e-01	0.841	0	0
SOS-mediated signalling	R-HSA-112412	1.443577e-01	0.841	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.443577e-01	0.841	0	0
Signaling by APC mutants	R-HSA-4839744	1.133659e-01	0.946	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.133659e-01	0.946	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.133659e-01	0.946	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.133659e-01	0.946	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.328617e-01	0.633	0	0
IRS activation	R-HSA-74713	2.328617e-01	0.633	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.328617e-01	0.633	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.328617e-01	0.633	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	8.981699e-02	1.047	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	1.755266e-01	0.756	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.755266e-01	0.756	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.356255e-01	0.868	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.356255e-01	0.868	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.356255e-01	0.868	0	0
DCC mediated attractive signaling	R-HSA-418885	1.063803e-01	0.973	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.063803e-01	0.973	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	1.063803e-01	0.973	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	1.063803e-01	0.973	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	8.429424e-02	1.074	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	8.429424e-02	1.074	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.802088e-02	1.108	0	0
Lipophagy	R-HSA-9613354	2.083407e-01	0.681	0	0
ALK mutants bind TKIs	R-HSA-9700645	2.083407e-01	0.681	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.808940e-01	0.551	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	2.808940e-01	0.551	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.808940e-01	0.551	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.808940e-01	0.551	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	2.808940e-01	0.551	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	4.070828e-01	0.390	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	4.070828e-01	0.390	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	4.070828e-01	0.390	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	4.070828e-01	0.390	0	0
Interaction between PHLDA1 and AURKA	R-HSA-8854521	4.070828e-01	0.390	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	4.070828e-01	0.390	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	4.070828e-01	0.390	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.070828e-01	0.390	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	4.070828e-01	0.390	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	4.070828e-01	0.390	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	4.070828e-01	0.390	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	4.070828e-01	0.390	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	4.070828e-01	0.390	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.070828e-01	0.390	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	4.070828e-01	0.390	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	4.070828e-01	0.390	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	4.070828e-01	0.390	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	4.070828e-01	0.390	0	0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	4.070828e-01	0.390	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.070828e-01	0.390	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	4.070828e-01	0.390	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	7.169096e-02	1.145	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	7.169096e-02	1.145	0	0
PI3K/AKT activation	R-HSA-198203	2.423660e-01	0.616	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	2.423660e-01	0.616	0	0
DNA methylation	R-HSA-5334118	9.249958e-02	1.034	0	0
Activation of the pre-replicative complex	R-HSA-68962	1.040737e-01	0.983	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.459159e-01	0.836	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.112026e-01	0.675	0	0
CREB phosphorylation	R-HSA-199920	3.286740e-01	0.483	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	3.286740e-01	0.483	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.286740e-01	0.483	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.838669e-02	1.165	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.301771e-01	0.885	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.771968e-01	0.557	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.454048e-01	0.837	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.386285e-01	0.622	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.386285e-01	0.622	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.035712e-01	0.985	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.079376e-01	0.682	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.276660e-01	0.894	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	1.021535e-01	0.991	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	1.002896e-01	0.999	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.782186e-01	0.749	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.312180e-01	0.636	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	2.312180e-01	0.636	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.668159e-01	0.574	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	3.124616e-01	0.505	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.124616e-01	0.505	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.755431e-01	0.425	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	3.755431e-01	0.425	0	0
Netrin mediated repulsion signals	R-HSA-418886	3.755431e-01	0.425	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.755431e-01	0.425	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	3.755431e-01	0.425	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	3.755431e-01	0.425	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	3.755431e-01	0.425	0	0
Axonal growth stimulation	R-HSA-209563	4.797240e-01	0.319	0	0
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	4.797240e-01	0.319	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.797240e-01	0.319	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	4.797240e-01	0.319	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.797240e-01	0.319	0	0
Invadopodia formation	R-HSA-8941237	4.797240e-01	0.319	0	0
Defective GCLC causes HAGGSD	R-HSA-5578999	4.797240e-01	0.319	0	0
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	4.797240e-01	0.319	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	7.154533e-02	1.145	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	8.819110e-02	1.055	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	8.819110e-02	1.055	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.093737e-01	0.961	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.093737e-01	0.961	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.729684e-01	0.762	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.957038e-01	0.708	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	2.226547e-01	0.652	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	2.226547e-01	0.652	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.551948e-01	0.593	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.673613e-01	0.776	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.955576e-01	0.529	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	2.955576e-01	0.529	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.086342e-01	0.964	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	3.478265e-01	0.459	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	1.748479e-01	0.757	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.797371e-01	0.553	0	0
Voltage gated Potassium channels	R-HSA-1296072	2.220199e-01	0.654	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.651737e-01	0.576	0	0
Packaging Of Telomere Ends	R-HSA-171306	2.651737e-01	0.576	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.651737e-01	0.576	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	4.210079e-01	0.376	0	0
Activation of RAS in B cells	R-HSA-1169092	4.210079e-01	0.376	0	0
FGFR1b ligand binding and activation	R-HSA-190370	4.210079e-01	0.376	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.596059e-01	0.797	0	0
Telomere Extension By Telomerase	R-HSA-171319	2.871629e-01	0.542	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.871629e-01	0.542	0	0
HIV elongation arrest and recovery	R-HSA-167287	2.871629e-01	0.542	0	0
Formation of the Early Elongation Complex	R-HSA-113418	2.871629e-01	0.542	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	2.871629e-01	0.542	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	2.871629e-01	0.542	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	3.829968e-01	0.417	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	3.829968e-01	0.417	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	3.829968e-01	0.417	0	0
HDACs deacetylate histones	R-HSA-3214815	2.073758e-01	0.683	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	3.539237e-01	0.451	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	3.095183e-01	0.509	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.754686e-01	0.560	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.754686e-01	0.560	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	2.940303e-01	0.532	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	3.321504e-01	0.479	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.321504e-01	0.479	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	3.554777e-01	0.449	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	3.831881e-01	0.417	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.831881e-01	0.417	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	4.177167e-01	0.379	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	5.434693e-01	0.265	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.434693e-01	0.265	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.077089e-01	0.683	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	3.128780e-01	0.505	0	0
Trafficking of AMPA receptors	R-HSA-399719	3.549718e-01	0.450	0	0
Tight junction interactions	R-HSA-420029	3.810229e-01	0.419	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	4.122900e-01	0.385	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	4.122900e-01	0.385	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	4.122900e-01	0.385	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	4.122900e-01	0.385	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	2.535207e-01	0.596	0	0
Erythropoietin activates RAS	R-HSA-9027284	4.517682e-01	0.345	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	4.517682e-01	0.345	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	4.517682e-01	0.345	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	4.008461e-01	0.397	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	5.063965e-01	0.296	0	0
HSF1-dependent transactivation	R-HSA-3371571	3.668140e-01	0.436	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.953553e-01	0.403	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	3.900821e-01	0.409	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	3.900821e-01	0.409	0	0
Striated Muscle Contraction	R-HSA-390522	4.237402e-01	0.373	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	4.237402e-01	0.373	0	0
Differentiation of T cells	R-HSA-9945266	4.849689e-01	0.314	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	4.849689e-01	0.314	0	0
Phosphorylation of the APC/C	R-HSA-176412	4.849689e-01	0.314	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	4.849689e-01	0.314	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.163605e-01	0.381	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	4.694471e-01	0.328	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.032839e-01	0.394	1	1
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.973855e-01	0.401	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.593098e-01	0.445	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.593098e-01	0.445	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.749083e-01	0.426	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.749083e-01	0.426	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.581307e-01	0.339	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.581307e-01	0.339	0	0
FGFR2 alternative splicing	R-HSA-6803529	4.972611e-01	0.303	0	0
Notch-HLH transcription pathway	R-HSA-350054	4.972611e-01	0.303	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	5.171697e-01	0.286	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.171697e-01	0.286	0	0
Phase 2 - plateau phase	R-HSA-5576893	5.171697e-01	0.286	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.171697e-01	0.286	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	5.459078e-01	0.263	0	0
Activation of AMPA receptors	R-HSA-399710	5.994077e-01	0.222	0	0
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	5.994077e-01	0.222	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	5.994077e-01	0.222	0	0
Defective F9 activation	R-HSA-9673221	5.994077e-01	0.222	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.994077e-01	0.222	0	0
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	5.994077e-01	0.222	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.994077e-01	0.222	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.994077e-01	0.222	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	5.994077e-01	0.222	0	0
Regulation of endogenous retroelements	R-HSA-9842860	4.077117e-01	0.390	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	4.135994e-01	0.383	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	4.490884e-01	0.348	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	4.490373e-01	0.348	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	4.913871e-01	0.309	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	5.062245e-01	0.296	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	4.646135e-01	0.333	0	0
Regulation of RAS by GAPs	R-HSA-5658442	4.869394e-01	0.313	0	0
Interleukin receptor SHC signaling	R-HSA-912526	5.244300e-01	0.280	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	5.482519e-01	0.261	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	5.482519e-01	0.261	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	5.482519e-01	0.261	0	0
EGFR downregulation	R-HSA-182971	5.301547e-01	0.276	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.013805e-01	0.300	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	5.246477e-01	0.280	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	5.508707e-01	0.259	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	5.508707e-01	0.259	0	0
Deadenylation of mRNA	R-HSA-429947	5.508707e-01	0.259	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.831503e-01	0.234	0	0
ERKs are inactivated	R-HSA-202670	5.831503e-01	0.234	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	5.535521e-01	0.257	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	5.562065e-01	0.255	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	5.781244e-01	0.238	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	5.444836e-01	0.264	0	0
Translation initiation complex formation	R-HSA-72649	5.613183e-01	0.251	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	5.765139e-01	0.239	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	5.763632e-01	0.239	0	0
Attenuation phase	R-HSA-3371568	5.769503e-01	0.239	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	5.899038e-01	0.229	0	0
Cellular response to heat stress	R-HSA-3371556	5.930538e-01	0.227	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.985426e-01	0.223	0	0
Regulation of signaling by CBL	R-HSA-912631	6.067207e-01	0.217	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	6.067207e-01	0.217	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.180870e-01	0.209	0	0
Polymerase switching	R-HSA-69091	6.180870e-01	0.209	0	0
Leading Strand Synthesis	R-HSA-69109	6.180870e-01	0.209	0	0
GRB2 events in EGFR signaling	R-HSA-179812	6.180870e-01	0.209	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	6.139403e-01	0.212	0	0
Estrogen-dependent gene expression	R-HSA-9018519	1.107120e-01	0.956	0	0
Transcription of the HIV genome	R-HSA-167172	5.335692e-01	0.273	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	4.038602e-01	0.394	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.749083e-01	0.426	0	0
RNA Polymerase III Transcription	R-HSA-74158	4.913871e-01	0.309	0	0
Integrin signaling	R-HSA-354192	1.433057e-01	0.844	0	0
RMTs methylate histone arginines	R-HSA-3214858	8.422666e-02	1.075	0	0
Regulation of necroptotic cell death	R-HSA-5675482	5.763632e-01	0.239	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	5.482519e-01	0.261	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	5.482519e-01	0.261	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	1.293601e-01	0.888	0	0
DAP12 signaling	R-HSA-2424491	3.321504e-01	0.479	0	0
Signaling by EGFR	R-HSA-177929	3.290421e-01	0.483	0	0
Hedgehog 'off' state	R-HSA-5610787	2.098504e-01	0.678	0	0
Downstream signal transduction	R-HSA-186763	5.301547e-01	0.276	0	0
HIV Transcription Elongation	R-HSA-167169	2.754686e-01	0.560	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	8.429424e-02	1.074	0	0
Formation of definitive endoderm	R-HSA-9823730	2.312180e-01	0.636	0	0
Signaling by SCF-KIT	R-HSA-1433557	1.367543e-01	0.864	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.066241e-01	0.972	0	0
Resolution of D-Loop Structures	R-HSA-5693537	4.237402e-01	0.373	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.935867e-01	0.532	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	5.062245e-01	0.296	0	0
Chromosome Maintenance	R-HSA-73886	1.760326e-01	0.754	0	0
DARPP-32 events	R-HSA-180024	9.249958e-02	1.034	0	0
Signaling by PDGFR in disease	R-HSA-9671555	2.797371e-01	0.553	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	1.137787e-01	0.944	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.300030e-01	0.481	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	4.008461e-01	0.397	0	0
Signaling by ERBB2	R-HSA-1227986	3.973855e-01	0.401	0	0
ESR-mediated signaling	R-HSA-8939211	2.984557e-01	0.525	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	7.282561e-02	1.138	0	0
Telomere Maintenance	R-HSA-157579	5.476791e-01	0.261	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	4.122900e-01	0.385	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	3.668140e-01	0.436	0	0
GP1b-IX-V activation signalling	R-HSA-430116	7.438102e-02	1.129	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	1.435593e-01	0.843	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.609451e-01	0.583	0	0
Eukaryotic Translation Elongation	R-HSA-156842	1.882419e-01	0.725	0	0
G0 and Early G1	R-HSA-1538133	3.778975e-01	0.423	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.179388e-01	0.498	0	0
p75NTR recruits signalling complexes	R-HSA-209543	6.180870e-01	0.209	0	0
TGFBR3 expression	R-HSA-9839394	2.226547e-01	0.652	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.754686e-01	0.560	0	0
Polo-like kinase mediated events	R-HSA-156711	1.854838e-01	0.732	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.493609e-01	0.826	0	0
Aggrephagy	R-HSA-9646399	5.769503e-01	0.239	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	1.596059e-01	0.797	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	3.398502e-01	0.469	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	5.392726e-01	0.268	0	0
Frs2-mediated activation	R-HSA-170968	7.470571e-02	1.127	0	0
p75NTR signals via NF-kB	R-HSA-193639	2.386285e-01	0.622	0	0
DNA Replication Pre-Initiation	R-HSA-69002	2.413799e-01	0.617	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	5.338313e-01	0.273	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	9.289642e-02	1.032	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.083407e-01	0.681	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	2.423660e-01	0.616	0	0
Regulation of the apoptosome activity	R-HSA-9627069	2.423660e-01	0.616	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	3.124616e-01	0.505	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.539237e-01	0.451	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	2.071754e-01	0.684	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.207174e-01	0.656	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.409488e-01	0.356	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.173105e-01	0.663	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.173105e-01	0.663	0	0
GAB1 signalosome	R-HSA-180292	5.781244e-01	0.238	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	5.256779e-01	0.279	0	0
DNA Double Strand Break Response	R-HSA-5693606	1.893563e-01	0.723	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	9.862295e-02	1.006	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	9.289642e-02	1.032	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	2.083407e-01	0.681	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	2.808940e-01	0.551	0	0
Formation of lateral plate mesoderm	R-HSA-9758920	2.808940e-01	0.551	0	0
Nuclear RNA decay	R-HSA-9930044	7.427710e-02	1.129	0	0
Formation of apoptosome	R-HSA-111458	2.423660e-01	0.616	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	1.639838e-01	0.785	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.771968e-01	0.557	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.294980e-01	0.888	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.755431e-01	0.425	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.817494e-01	0.741	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.572453e-01	0.590	0	0
DNA strand elongation	R-HSA-69190	3.778975e-01	0.423	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	4.517682e-01	0.345	0	0
Regulation of CDH11 function	R-HSA-9762292	5.063965e-01	0.296	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.710049e-01	0.431	0	0
Peptide chain elongation	R-HSA-156902	3.910464e-01	0.408	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	4.972611e-01	0.303	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	5.482519e-01	0.261	0	0
G-protein beta:gamma signalling	R-HSA-397795	5.763632e-01	0.239	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.820524e-01	0.235	1	0
Regulation of mitotic cell cycle	R-HSA-453276	5.820524e-01	0.235	1	0
Clathrin-mediated endocytosis	R-HSA-8856828	6.195546e-01	0.208	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	3.918234e-01	0.407	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.527749e-01	0.597	0	0
Oncogene Induced Senescence	R-HSA-2559585	4.690765e-01	0.329	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.787880e-01	0.320	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	1.433057e-01	0.844	1	1
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.729684e-01	0.762	0	0
Calmodulin induced events	R-HSA-111933	2.051176e-01	0.688	0	0
Assembly of the pre-replicative complex	R-HSA-68867	1.357553e-01	0.867	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.155401e-01	0.937	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.915321e-01	0.535	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	5.278539e-01	0.277	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	5.512280e-01	0.259	0	0
Synthesis of DNA	R-HSA-69239	5.899038e-01	0.229	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.130364e-01	0.504	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	1.140624e-01	0.943	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.535337e-01	0.814	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.694471e-01	0.328	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	4.760455e-01	0.322	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.924325e-01	0.716	0	0
S Phase	R-HSA-69242	1.078435e-01	0.967	0	0
Homology Directed Repair	R-HSA-5693538	2.111469e-01	0.675	0	0
TNF signaling	R-HSA-75893	3.290421e-01	0.483	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	7.470571e-02	1.127	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	7.470571e-02	1.127	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	2.328617e-01	0.633	0	0
Adrenoceptors	R-HSA-390696	1.755266e-01	0.756	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	1.594880e-01	0.797	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	2.083407e-01	0.681	0	0
cGMP effects	R-HSA-418457	2.112026e-01	0.675	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	2.668159e-01	0.574	0	0
NF-kB is activated and signals survival	R-HSA-209560	3.124616e-01	0.505	0	0
CaM pathway	R-HSA-111997	2.051176e-01	0.688	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.210079e-01	0.376	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	3.539237e-01	0.451	0	0
Orc1 removal from chromatin	R-HSA-68949	2.634125e-01	0.579	0	0
p75NTR regulates axonogenesis	R-HSA-193697	4.647090e-01	0.333	0	0
Regulation of gap junction activity	R-HSA-191650	5.434693e-01	0.265	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	3.325667e-01	0.478	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.663451e-01	0.575	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	4.517682e-01	0.345	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	3.249595e-01	0.488	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.171697e-01	0.286	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.562065e-01	0.255	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	6.180870e-01	0.209	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	6.180870e-01	0.209	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.909960e-01	0.719	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	1.909960e-01	0.719	0	0
Mitophagy	R-HSA-5205647	6.200524e-01	0.208	0	0
Interleukin-2 signaling	R-HSA-9020558	2.771968e-01	0.557	0	0
Regulation of TP53 Degradation	R-HSA-6804757	2.051176e-01	0.688	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.293286e-01	0.640	0	0
Stabilization of p53	R-HSA-69541	5.562065e-01	0.255	0	0
Autophagy	R-HSA-9612973	3.439331e-01	0.464	0	0
MTOR signalling	R-HSA-165159	6.838669e-02	1.165	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.436408e-01	0.613	0	0
Cap-dependent Translation Initiation	R-HSA-72737	5.312651e-01	0.275	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	6.149925e-01	0.211	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	8.827590e-02	1.054	0	0
Signaling by WNT	R-HSA-195721	1.745447e-01	0.758	0	0
Signalling to ERKs	R-HSA-187687	1.043231e-01	0.982	0	0
PLC beta mediated events	R-HSA-112043	2.955953e-01	0.529	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	2.423660e-01	0.616	0	0
Signal attenuation	R-HSA-74749	2.423660e-01	0.616	0	0
Repression of WNT target genes	R-HSA-4641265	3.478265e-01	0.459	0	0
DAG and IP3 signaling	R-HSA-1489509	2.609451e-01	0.583	0	0
Long-term potentiation	R-HSA-9620244	3.810229e-01	0.419	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	5.062245e-01	0.296	0	0
Eukaryotic Translation Initiation	R-HSA-72613	5.312651e-01	0.275	0	0
Apoptotic factor-mediated response	R-HSA-111471	5.781244e-01	0.238	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.180870e-01	0.209	0	0
Mitotic Prophase	R-HSA-68875	3.056402e-01	0.515	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	3.567653e-01	0.448	0	0
Ub-specific processing proteases	R-HSA-5689880	7.274853e-02	1.138	0	0
Switching of origins to a post-replicative state	R-HSA-69052	2.663197e-01	0.575	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.783762e-01	0.749	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	3.477048e-01	0.459	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.567439e-01	0.805	0	0
Selective autophagy	R-HSA-9663891	3.910464e-01	0.408	0	0
Signaling by Hedgehog	R-HSA-5358351	4.634011e-01	0.334	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	9.289642e-02	1.032	0	0
Signaling by WNT in cancer	R-HSA-4791275	2.325446e-01	0.633	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	3.810229e-01	0.419	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	1.433057e-01	0.844	0	0
Interleukin-1 signaling	R-HSA-9020702	3.943234e-01	0.404	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	5.788285e-01	0.237	0	0
Hedgehog 'on' state	R-HSA-5632684	1.596059e-01	0.797	0	0
Calcineurin activates NFAT	R-HSA-2025928	2.083407e-01	0.681	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.808940e-01	0.551	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.112026e-01	0.675	0	0
Abacavir transmembrane transport	R-HSA-2161517	3.286740e-01	0.483	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.386285e-01	0.622	0	0
Cardiogenesis	R-HSA-9733709	1.433057e-01	0.844	0	0
Ca2+ activated K+ channels	R-HSA-1296052	3.755431e-01	0.425	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.210079e-01	0.376	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	4.210079e-01	0.376	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	4.210079e-01	0.376	0	0
Defective pyroptosis	R-HSA-9710421	2.279593e-01	0.642	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.829968e-01	0.417	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	2.714605e-01	0.566	0	0
Post NMDA receptor activation events	R-HSA-438064	1.968886e-01	0.706	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.321504e-01	0.479	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.831881e-01	0.417	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	4.647090e-01	0.333	0	0
Ca-dependent events	R-HSA-111996	3.319591e-01	0.479	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	4.008461e-01	0.397	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.410858e-01	0.355	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.171697e-01	0.286	0	0
Formation of the posterior neural plate	R-HSA-9832991	5.459078e-01	0.263	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.994077e-01	0.222	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.021104e-01	0.396	0	0
Macroautophagy	R-HSA-1632852	4.113322e-01	0.386	0	0
MET promotes cell motility	R-HSA-8875878	5.350023e-01	0.272	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.765139e-01	0.239	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	6.180870e-01	0.209	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	6.200524e-01	0.208	0	0
Signaling by VEGF	R-HSA-194138	1.608270e-01	0.794	0	0
PTEN Regulation	R-HSA-6807070	5.639710e-01	0.249	0	0
Signaling by FGFR in disease	R-HSA-1226099	2.801056e-01	0.553	0	0
Ion homeostasis	R-HSA-5578775	1.393917e-01	0.856	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.460622e-01	0.609	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.517757e-01	0.599	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	4.570193e-01	0.340	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	4.818227e-01	0.317	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.985426e-01	0.223	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	6.200524e-01	0.208	0	0
Signaling by NOTCH1	R-HSA-1980143	5.374702e-01	0.270	0	0
Generic Transcription Pathway	R-HSA-212436	9.459427e-02	1.024	1	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.938834e-01	0.712	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.386285e-01	0.622	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	2.517757e-01	0.599	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	5.171697e-01	0.286	0	0
Signaling by ALK in cancer	R-HSA-9700206	1.567439e-01	0.805	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	4.400864e-01	0.356	0	0
Platelet calcium homeostasis	R-HSA-418360	3.095183e-01	0.509	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	5.966881e-01	0.224	0	0
Intracellular signaling by second messengers	R-HSA-9006925	7.017193e-02	1.154	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.801067e-01	0.744	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	2.940303e-01	0.532	0	0
Biotin transport and metabolism	R-HSA-196780	4.517682e-01	0.345	0	0
TCR signaling	R-HSA-202403	2.520744e-01	0.598	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	1.213024e-01	0.916	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.346421e-01	0.871	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	4.724369e-01	0.326	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	6.524484e-02	1.185	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	1.854372e-01	0.732	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	4.210079e-01	0.376	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	2.394121e-01	0.621	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	5.063965e-01	0.296	0	0
Meiotic recombination	R-HSA-912446	3.668140e-01	0.436	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.994077e-01	0.222	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	5.133800e-01	0.290	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	5.763632e-01	0.239	0	0
Ca2+ pathway	R-HSA-4086398	3.710049e-01	0.431	0	0
PIP3 activates AKT signaling	R-HSA-1257604	9.721634e-02	1.012	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	4.724369e-01	0.326	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	5.099689e-01	0.292	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	4.435455e-01	0.353	0	0
Generation of second messenger molecules	R-HSA-202433	4.163605e-01	0.381	0	0
Mismatch Repair	R-HSA-5358508	5.781244e-01	0.238	0	0
Integration of energy metabolism	R-HSA-163685	3.551159e-01	0.450	0	0
Glycogen metabolism	R-HSA-8982491	5.769503e-01	0.239	0	0
Developmental Biology	R-HSA-1266738	4.870120e-01	0.312	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	5.099689e-01	0.292	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	5.145769e-01	0.289	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.063803e-01	0.973	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	2.955576e-01	0.529	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.119232e-01	0.506	0	0
Ovarian tumor domain proteases	R-HSA-5689896	3.533963e-01	0.452	0	0
Deubiquitination	R-HSA-5688426	1.354697e-01	0.868	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.544920e-01	0.450	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	4.818227e-01	0.317	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	6.013033e-01	0.221	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.409767e-01	0.618	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.409767e-01	0.618	0	0
Metabolism of RNA	R-HSA-8953854	5.847221e-01	0.233	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.544920e-01	0.450	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.544920e-01	0.450	0	0
G-protein mediated events	R-HSA-112040	3.918234e-01	0.407	0	0
G1/S Transition	R-HSA-69206	2.204943e-01	0.657	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	3.755431e-01	0.425	0	0
mRNA Editing	R-HSA-75072	4.647090e-01	0.333	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	4.146333e-01	0.382	0	0
Spry regulation of FGF signaling	R-HSA-1295596	4.517682e-01	0.345	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	2.929691e-01	0.533	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	4.569016e-01	0.340	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	6.168113e-01	0.210	0	0
Neuronal System	R-HSA-112316	1.988746e-01	0.701	0	0
Opioid Signalling	R-HSA-111885	3.380170e-01	0.471	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	5.508707e-01	0.259	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.007823e-01	0.997	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.555409e-01	0.449	0	0
Membrane Trafficking	R-HSA-199991	3.227343e-01	0.491	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	1.855372e-01	0.732	0	0
Specification of the neural plate border	R-HSA-9834899	6.067207e-01	0.217	0	0
Programmed Cell Death	R-HSA-5357801	1.298971e-01	0.886	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	5.021760e-01	0.299	0	0
Signaling by TGFBR3	R-HSA-9839373	2.779746e-01	0.556	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.735498e-01	0.325	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.850955e-01	0.733	0	0
DNA Repair	R-HSA-73894	5.568120e-01	0.254	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	8.433958e-02	1.074	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	6.549593e-02	1.184	1	0
NGF-stimulated transcription	R-HSA-9031628	3.128992e-01	0.505	0	0
Interleukin-1 family signaling	R-HSA-446652	9.366225e-02	1.028	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.448069e-01	0.839	0	0
Signaling by PTK6	R-HSA-8848021	1.448069e-01	0.839	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.663596e-01	0.247	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	2.299763e-01	0.638	0	0
Inhibition of PKR	R-HSA-169131	2.299763e-01	0.638	0	0
Unwinding of DNA	R-HSA-176974	7.438102e-02	1.129	0	0
MTF1 activates gene expression	R-HSA-5660489	1.854372e-01	0.732	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	3.243048e-01	0.489	0	0
Tandem pore domain potassium channels	R-HSA-1296346	9.289642e-02	1.032	0	0
Regulation of PTEN localization	R-HSA-8948747	1.443577e-01	0.841	0	0
Signaling by AXIN mutants	R-HSA-4839735	1.356255e-01	0.868	0	0
Signaling by AMER1 mutants	R-HSA-4839748	1.356255e-01	0.868	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	8.429424e-02	1.074	0	0
The NLRP3 inflammasome	R-HSA-844456	9.807232e-02	1.008	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	1.243239e-01	0.905	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	4.070828e-01	0.390	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	4.070828e-01	0.390	0	0
C6 deamination of adenosine	R-HSA-75102	4.070828e-01	0.390	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	2.423660e-01	0.616	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	1.459159e-01	0.836	0	0
mTORC1-mediated signalling	R-HSA-166208	1.638547e-01	0.786	0	0
Negative regulation of FLT3	R-HSA-9706369	2.668159e-01	0.574	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	4.797240e-01	0.319	0	0
MET interacts with TNS proteins	R-HSA-8875513	4.797240e-01	0.319	0	0
Signaling by LTK	R-HSA-9842663	3.478265e-01	0.459	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	2.651737e-01	0.576	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.210079e-01	0.376	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	3.829968e-01	0.417	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.915321e-01	0.535	0	0
Mitotic Anaphase	R-HSA-68882	6.239979e-02	1.205	1	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	4.647090e-01	0.333	0	0
Alanine metabolism	R-HSA-8964540	5.434693e-01	0.265	0	0
Electric Transmission Across Gap Junctions	R-HSA-112303	5.434693e-01	0.265	0	0
Transmission across Electrical Synapses	R-HSA-112307	5.434693e-01	0.265	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	5.063965e-01	0.296	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	5.063965e-01	0.296	0	0
Cristae formation	R-HSA-8949613	4.318924e-01	0.365	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.694471e-01	0.328	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.861565e-01	0.543	0	0
MAP kinase activation	R-HSA-450294	4.146333e-01	0.382	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.858993e-01	0.414	0	0
Disorders of Developmental Biology	R-HSA-9675151	5.171697e-01	0.286	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.994077e-01	0.222	0	0
Suppression of autophagy	R-HSA-9636569	5.994077e-01	0.222	0	0
Cell junction organization	R-HSA-446728	3.313800e-01	0.480	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	5.013805e-01	0.300	0	0
Sodium/Calcium exchangers	R-HSA-425561	5.831503e-01	0.234	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.038164e-01	0.219	0	0
Metalloprotease DUBs	R-HSA-5689901	6.013033e-01	0.221	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	6.180870e-01	0.209	0	0
Cell-cell junction organization	R-HSA-421270	6.174304e-01	0.209	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	5.936337e-01	0.226	0	0
FLT3 signaling in disease	R-HSA-9682385	3.325667e-01	0.478	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.535867e-01	0.596	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	5.967112e-01	0.224	0	0
Interleukin-2 family signaling	R-HSA-451927	4.163605e-01	0.381	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	6.246418e-02	1.204	0	0
Cell-Cell communication	R-HSA-1500931	3.948604e-01	0.404	0	0
Interleukin-17 signaling	R-HSA-448424	5.661295e-01	0.247	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	1.125063e-01	0.949	1	0
Potassium Channels	R-HSA-1296071	3.283758e-01	0.484	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	5.276856e-01	0.278	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	5.276856e-01	0.278	0	0
Signaling by ERBB4	R-HSA-1236394	1.924325e-01	0.716	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	4.163605e-01	0.381	0	0
Signaling by NTRKs	R-HSA-166520	2.019584e-01	0.695	0	0
Smooth Muscle Contraction	R-HSA-445355	2.794423e-01	0.554	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.616335e-01	0.791	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	4.210079e-01	0.376	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	2.517757e-01	0.599	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	5.171697e-01	0.286	0	0
EPHB-mediated forward signaling	R-HSA-3928662	1.489289e-01	0.827	0	0
Formation of the nephric duct	R-HSA-9830364	1.157933e-01	0.936	0	0
Activation of BH3-only proteins	R-HSA-114452	5.062245e-01	0.296	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	4.613987e-01	0.336	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	5.779480e-01	0.238	0	0
Stimuli-sensing channels	R-HSA-2672351	1.651923e-01	0.782	0	0
Interleukin-1 processing	R-HSA-448706	2.083407e-01	0.681	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	2.083407e-01	0.681	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	2.083407e-01	0.681	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	1.638547e-01	0.786	0	0
CHL1 interactions	R-HSA-447041	3.755431e-01	0.425	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	3.829968e-01	0.417	0	0
Processing of SMDT1	R-HSA-8949664	3.829968e-01	0.417	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	4.177167e-01	0.379	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	5.434693e-01	0.265	0	0
Protein hydroxylation	R-HSA-9629569	4.122900e-01	0.385	0	0
Rab regulation of trafficking	R-HSA-9007101	3.553219e-01	0.449	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	5.459078e-01	0.263	0	0
Disorders of Nervous System Development	R-HSA-9697154	6.180870e-01	0.209	0	0
Pervasive developmental disorders	R-HSA-9005895	6.180870e-01	0.209	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.180870e-01	0.209	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	5.587992e-01	0.253	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	5.587992e-01	0.253	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	4.465064e-01	0.350	0	0
Reproduction	R-HSA-1474165	1.542590e-01	0.812	0	0
MHC class II antigen presentation	R-HSA-2132295	5.223546e-01	0.282	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.071792e-02	1.150	0	0
Ion channel transport	R-HSA-983712	6.161294e-01	0.210	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	1.485392e-01	0.828	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.647090e-01	0.333	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	6.013033e-01	0.221	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.854838e-01	0.732	0	0
Signaling by ALK	R-HSA-201556	2.572453e-01	0.590	0	0
L1CAM interactions	R-HSA-373760	4.345897e-01	0.362	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	5.482519e-01	0.261	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	2.378359e-01	0.624	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	4.318924e-01	0.365	0	0
Kidney development	R-HSA-9830369	5.169752e-01	0.287	0	0
PI Metabolism	R-HSA-1483255	3.130364e-01	0.504	0	0
Breakdown of the nuclear lamina	R-HSA-352238	3.243048e-01	0.489	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	1.243239e-01	0.905	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.808940e-01	0.551	0	0
DSCAM interactions	R-HSA-376172	4.070828e-01	0.390	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.797240e-01	0.319	0	0
Alpha-defensins	R-HSA-1462054	4.210079e-01	0.376	0	0
Maturation of nucleoprotein	R-HSA-9683610	3.829968e-01	0.417	0	0
Syndecan interactions	R-HSA-3000170	3.300030e-01	0.481	0	0
Physiological factors	R-HSA-5578768	4.177167e-01	0.379	0	0
Sensory perception of sour taste	R-HSA-9729555	5.434693e-01	0.265	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	4.410858e-01	0.355	0	0
Synthesis of PI	R-HSA-1483226	5.459078e-01	0.263	0	0
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	5.994077e-01	0.222	0	0
PTK6 Down-Regulation	R-HSA-8849472	5.994077e-01	0.222	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	5.559666e-01	0.255	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	5.834731e-01	0.234	0	0
Inflammasomes	R-HSA-622312	2.871629e-01	0.542	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.249595e-01	0.488	0	0
Co-stimulation by CD28	R-HSA-389356	3.128992e-01	0.505	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.517757e-01	0.599	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	5.687108e-01	0.245	0	0
Sensory processing of sound	R-HSA-9659379	2.533622e-01	0.596	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.083407e-01	0.681	0	0
Cell-extracellular matrix interactions	R-HSA-446353	2.386285e-01	0.622	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.014048e-01	0.696	0	0
G1/S-Specific Transcription	R-HSA-69205	3.325667e-01	0.478	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	5.063965e-01	0.296	0	0
Signaling by Interleukins	R-HSA-449147	1.561385e-01	0.806	0	0
Formation of the anterior neural plate	R-HSA-9823739	4.517682e-01	0.345	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.246477e-01	0.280	0	0
Diseases of DNA repair	R-HSA-9675135	4.095809e-01	0.388	0	0
Specification of primordial germ cells	R-HSA-9827857	1.639838e-01	0.785	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	3.755431e-01	0.425	0	0
Interleukin-18 signaling	R-HSA-9012546	4.210079e-01	0.376	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.212619e-01	0.655	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	5.434693e-01	0.265	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.434693e-01	0.265	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	5.434693e-01	0.265	0	0
NrCAM interactions	R-HSA-447038	5.994077e-01	0.222	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	5.994077e-01	0.222	0	0
Estrogen biosynthesis	R-HSA-193144	6.180870e-01	0.209	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.291899e-01	0.889	0	0
Interleukin-7 signaling	R-HSA-1266695	1.157933e-01	0.936	0	0
Cleavage of the damaged purine	R-HSA-110331	5.133800e-01	0.290	0	0
Maturation of nucleoprotein	R-HSA-9694631	6.067207e-01	0.217	0	0
Depurination	R-HSA-73927	5.350023e-01	0.272	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.808940e-01	0.551	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	2.771968e-01	0.557	0	0
OAS antiviral response	R-HSA-8983711	3.478265e-01	0.459	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	3.778975e-01	0.423	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	5.994077e-01	0.222	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.539237e-01	0.451	0	0
Interleukin-15 signaling	R-HSA-8983432	6.180870e-01	0.209	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	3.829968e-01	0.417	0	0
SARS-CoV-1 Infection	R-HSA-9678108	5.546889e-01	0.256	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	4.787880e-01	0.320	0	0
Depyrimidination	R-HSA-73928	4.787880e-01	0.320	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	2.915321e-01	0.535	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	4.694471e-01	0.328	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	4.832804e-01	0.316	0	0
Signaling by Leptin	R-HSA-2586552	5.063965e-01	0.296	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	6.251948e-01	0.204	0	0
Eukaryotic Translation Termination	R-HSA-72764	6.272213e-01	0.203	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	6.306297e-01	0.200	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.339959e-01	0.198	0	0
Co-inhibition by CTLA4	R-HSA-389513	6.339959e-01	0.198	0	0
Signaling by NODAL	R-HSA-1181150	6.339959e-01	0.198	0	0
Signal transduction by L1	R-HSA-445144	6.339959e-01	0.198	0	0
Creatine metabolism	R-HSA-71288	6.339959e-01	0.198	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	6.360740e-01	0.196	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.399340e-01	0.194	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	6.408618e-01	0.193	0	0
DNA Replication	R-HSA-69306	6.413372e-01	0.193	0	0
Extension of Telomeres	R-HSA-180786	6.469861e-01	0.189	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	6.481553e-01	0.188	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.484948e-01	0.188	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.484948e-01	0.188	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.484948e-01	0.188	0	0
PKB-mediated events	R-HSA-109703	6.484948e-01	0.188	0	0
Cam-PDE 1 activation	R-HSA-111957	6.484948e-01	0.188	0	0
PDE3B signalling	R-HSA-165160	6.484948e-01	0.188	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.484948e-01	0.188	0	0
Defective CSF2RA causes SMDP4	R-HSA-5688890	6.484948e-01	0.188	0	0
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	6.484948e-01	0.188	0	0
Signaling by RNF43 mutants	R-HSA-5340588	6.484948e-01	0.188	0	0
Defective CSF2RB causes SMDP5	R-HSA-5688849	6.484948e-01	0.188	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.484948e-01	0.188	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	6.484948e-01	0.188	0	0
Formation of the Editosome	R-HSA-75094	6.484948e-01	0.188	0	0
Phosphorylation of Emi1	R-HSA-176417	6.484948e-01	0.188	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	6.484948e-01	0.188	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.484948e-01	0.188	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	6.484948e-01	0.188	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.484948e-01	0.188	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	6.484948e-01	0.188	0	0
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	6.484948e-01	0.188	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.484948e-01	0.188	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.484948e-01	0.188	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.484948e-01	0.188	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	6.507236e-01	0.187	0	0
Formation of axial mesoderm	R-HSA-9796292	6.507236e-01	0.187	0	0
FGFR1c ligand binding and activation	R-HSA-190373	6.507236e-01	0.187	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	6.507236e-01	0.187	0	0
Signaling by FGFR4	R-HSA-5654743	6.546555e-01	0.184	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.573711e-01	0.182	0	0
Interleukin-12 signaling	R-HSA-9020591	6.573711e-01	0.182	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	6.599244e-01	0.181	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	6.599244e-01	0.181	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	6.599244e-01	0.181	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	6.599244e-01	0.181	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	6.599244e-01	0.181	0	0
Signalling to RAS	R-HSA-167044	6.599244e-01	0.181	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	6.599244e-01	0.181	0	0
HSF1 activation	R-HSA-3371511	6.609467e-01	0.180	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	6.609467e-01	0.180	0	0
GPVI-mediated activation cascade	R-HSA-114604	6.609467e-01	0.180	0	0
Regulation of insulin secretion	R-HSA-422356	6.656438e-01	0.177	0	0
Signaling by Erythropoietin	R-HSA-9006335	6.701620e-01	0.174	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	6.701620e-01	0.174	0	0
mRNA Capping	R-HSA-72086	6.701620e-01	0.174	0	0
Late endosomal microautophagy	R-HSA-9615710	6.701620e-01	0.174	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	6.701620e-01	0.174	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.701620e-01	0.174	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	6.714751e-01	0.173	0	0
Adherens junctions interactions	R-HSA-418990	6.722162e-01	0.172	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	6.726402e-01	0.172	0	0
G1 Phase	R-HSA-69236	6.726402e-01	0.172	0	0
Cyclin D associated events in G1	R-HSA-69231	6.726402e-01	0.172	0	0
DAP12 interactions	R-HSA-2172127	6.726402e-01	0.172	0	0
Amine ligand-binding receptors	R-HSA-375280	6.726402e-01	0.172	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	6.745267e-01	0.171	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	6.784161e-01	0.169	0	0
Degradation of DVL	R-HSA-4641258	6.802893e-01	0.167	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	6.802893e-01	0.167	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.802893e-01	0.167	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.810992e-01	0.167	0	0
Removal of the Flap Intermediate	R-HSA-69166	6.810992e-01	0.167	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	6.810992e-01	0.167	0	0
CRMPs in Sema3A signaling	R-HSA-399956	6.810992e-01	0.167	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	6.810992e-01	0.167	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	6.810992e-01	0.167	0	0
HDL assembly	R-HSA-8963896	6.810992e-01	0.167	0	0
Signal regulatory protein family interactions	R-HSA-391160	6.810992e-01	0.167	0	0
P2Y receptors	R-HSA-417957	6.810992e-01	0.167	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.810992e-01	0.167	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.834316e-01	0.165	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	6.844965e-01	0.165	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	6.844965e-01	0.165	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	6.844965e-01	0.165	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	6.844965e-01	0.165	0	0
PCP/CE pathway	R-HSA-4086400	6.852331e-01	0.164	0	0
RNA Polymerase I Transcription	R-HSA-73864	6.852331e-01	0.164	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	6.888332e-01	0.162	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	6.888895e-01	0.162	0	0
Signaling by FGFR3	R-HSA-5654741	6.900142e-01	0.161	0	0
STAT5 Activation	R-HSA-9645135	6.915695e-01	0.160	0	0
Erythropoietin activates STAT5	R-HSA-9027283	6.915695e-01	0.160	0	0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	6.915695e-01	0.160	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.915695e-01	0.160	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	6.915695e-01	0.160	0	0
Neurofascin interactions	R-HSA-447043	6.915695e-01	0.160	0	0
NADPH regeneration	R-HSA-389542	6.915695e-01	0.160	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.915695e-01	0.160	0	0
Nef and signal transduction	R-HSA-164944	6.915695e-01	0.160	0	0
Lipid particle organization	R-HSA-8964572	6.915695e-01	0.160	0	0
Heme signaling	R-HSA-9707616	6.934659e-01	0.159	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.951874e-01	0.158	0	0
Cilium Assembly	R-HSA-5617833	6.979005e-01	0.156	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.988775e-01	0.156	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	6.992700e-01	0.155	0	0
Selenocysteine synthesis	R-HSA-2408557	7.017622e-01	0.154	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	7.067677e-01	0.151	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.067677e-01	0.151	0	0
Signaling by KIT in disease	R-HSA-9669938	7.077167e-01	0.150	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.077167e-01	0.150	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.077167e-01	0.150	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.077167e-01	0.150	0	0
Ethanol oxidation	R-HSA-71384	7.077167e-01	0.150	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.077167e-01	0.150	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	7.077167e-01	0.150	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	7.092778e-01	0.149	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	7.092778e-01	0.149	0	0
SHC1 events in EGFR signaling	R-HSA-180336	7.092778e-01	0.149	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	7.092778e-01	0.149	0	0
Processive synthesis on the lagging strand	R-HSA-69183	7.092778e-01	0.149	0	0
p38MAPK events	R-HSA-171007	7.092778e-01	0.149	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	7.092778e-01	0.149	0	0
Protein methylation	R-HSA-8876725	7.092778e-01	0.149	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	7.092778e-01	0.149	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	7.092778e-01	0.149	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	7.112673e-01	0.148	0	0
Signaling by FGFR2	R-HSA-5654738	7.116798e-01	0.148	0	0
Co-inhibition by PD-1	R-HSA-389948	7.142781e-01	0.146	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	7.167045e-01	0.145	0	0
IGF1R signaling cascade	R-HSA-2428924	7.221933e-01	0.141	0	0
Amyloid fiber formation	R-HSA-977225	7.243566e-01	0.140	0	0
Viral mRNA Translation	R-HSA-192823	7.244774e-01	0.140	0	0
Adipogenesis	R-HSA-9843745	7.247795e-01	0.140	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	7.279092e-01	0.138	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	7.293558e-01	0.137	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	7.293558e-01	0.137	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.293558e-01	0.137	0	0
Signaling by FGFR1	R-HSA-5654736	7.293558e-01	0.137	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	7.293678e-01	0.137	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.293678e-01	0.137	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	7.293678e-01	0.137	0	0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	7.293678e-01	0.137	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	7.293678e-01	0.137	0	0
Disinhibition of SNARE formation	R-HSA-114516	7.293678e-01	0.137	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	7.293678e-01	0.137	0	0
PTK6 Expression	R-HSA-8849473	7.293678e-01	0.137	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	7.293678e-01	0.137	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	7.293678e-01	0.137	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	7.293678e-01	0.137	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	7.293678e-01	0.137	0	0
Glycoprotein hormones	R-HSA-209822	7.293678e-01	0.137	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	7.293678e-01	0.137	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	7.293678e-01	0.137	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	7.293678e-01	0.137	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.296012e-01	0.137	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.296012e-01	0.137	0	0
Formation of the ureteric bud	R-HSA-9830674	7.296012e-01	0.137	0	0
Carnitine shuttle	R-HSA-200425	7.296012e-01	0.137	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	7.296012e-01	0.137	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	7.303623e-01	0.136	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	7.337684e-01	0.134	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	7.337684e-01	0.134	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.337684e-01	0.134	0	0
Diseases of Immune System	R-HSA-5260271	7.337684e-01	0.134	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	7.353416e-01	0.134	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	7.353416e-01	0.134	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	7.353416e-01	0.134	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	7.353416e-01	0.134	0	0
Killing mechanisms	R-HSA-9664420	7.353416e-01	0.134	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	7.353416e-01	0.134	0	0
Fructose catabolism	R-HSA-70350	7.353416e-01	0.134	0	0
Regulation of BACH1 activity	R-HSA-9708530	7.353416e-01	0.134	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	7.353416e-01	0.134	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	7.353416e-01	0.134	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	7.353416e-01	0.134	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	7.354129e-01	0.133	0	0
Cellular response to hypoxia	R-HSA-1234174	7.358604e-01	0.133	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	7.358604e-01	0.133	0	0
Downstream TCR signaling	R-HSA-202424	7.435035e-01	0.129	0	0
IRS-mediated signalling	R-HSA-112399	7.435953e-01	0.129	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	7.484942e-01	0.126	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	7.500715e-01	0.125	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	7.500876e-01	0.125	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.501760e-01	0.125	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.501760e-01	0.125	0	0
Degradation of CDH1	R-HSA-9766229	7.532603e-01	0.123	0	0
ISG15 antiviral mechanism	R-HSA-1169408	7.546120e-01	0.122	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	7.593856e-01	0.120	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	7.593856e-01	0.120	0	0
Passive transport by Aquaporins	R-HSA-432047	7.593856e-01	0.120	0	0
tRNA modification in the mitochondrion	R-HSA-6787450	7.593856e-01	0.120	0	0
Synthesis of PG	R-HSA-1483148	7.593856e-01	0.120	0	0
Response to metal ions	R-HSA-5660526	7.593856e-01	0.120	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	7.625310e-01	0.118	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.625359e-01	0.118	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	7.625359e-01	0.118	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.625359e-01	0.118	0	0
Regulation by c-FLIP	R-HSA-3371378	7.625359e-01	0.118	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	7.625359e-01	0.118	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	7.625359e-01	0.118	0	0
Dimerization of procaspase-8	R-HSA-69416	7.625359e-01	0.118	0	0
TGFBR3 PTM regulation	R-HSA-9839383	7.625359e-01	0.118	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.625359e-01	0.118	0	0
Sodium/Proton exchangers	R-HSA-425986	7.625359e-01	0.118	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	7.625359e-01	0.118	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.656200e-01	0.116	0	0
HIV Transcription Initiation	R-HSA-167161	7.656200e-01	0.116	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.656200e-01	0.116	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	7.656200e-01	0.116	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	7.656200e-01	0.116	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.656766e-01	0.116	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.656766e-01	0.116	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	7.656766e-01	0.116	0	0
Platelet homeostasis	R-HSA-418346	7.665006e-01	0.115	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	7.675025e-01	0.115	0	0
PI3K Cascade	R-HSA-109704	7.675025e-01	0.115	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.694747e-01	0.114	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	7.694747e-01	0.114	0	0
Acyl chain remodelling of PS	R-HSA-1482801	7.694747e-01	0.114	0	0
Metabolism of non-coding RNA	R-HSA-194441	7.704652e-01	0.113	0	0
snRNP Assembly	R-HSA-191859	7.704652e-01	0.113	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	7.815135e-01	0.107	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	7.815135e-01	0.107	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	7.815135e-01	0.107	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	7.815135e-01	0.107	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	7.815135e-01	0.107	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	7.815135e-01	0.107	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.819278e-01	0.107	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.819278e-01	0.107	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	7.831010e-01	0.106	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	7.831010e-01	0.106	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	7.831010e-01	0.106	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	7.831010e-01	0.106	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	7.831010e-01	0.106	0	0
Transmission across Chemical Synapses	R-HSA-112315	7.865002e-01	0.104	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	7.875375e-01	0.104	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.875375e-01	0.104	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.875375e-01	0.104	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	7.907010e-01	0.102	0	0
Interleukin-21 signaling	R-HSA-9020958	7.916407e-01	0.101	0	0
WNT mediated activation of DVL	R-HSA-201688	7.916407e-01	0.101	0	0
CASP8 activity is inhibited	R-HSA-5218900	7.916407e-01	0.101	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.916407e-01	0.101	0	0
Regulation of signaling by NODAL	R-HSA-1433617	7.916407e-01	0.101	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.916407e-01	0.101	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.916407e-01	0.101	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	7.916407e-01	0.101	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.916407e-01	0.101	0	0
Lysosomal oligosaccharide catabolism	R-HSA-8853383	7.916407e-01	0.101	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	7.916407e-01	0.101	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	7.916407e-01	0.101	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.916407e-01	0.101	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.941334e-01	0.100	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	7.941334e-01	0.100	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	7.941334e-01	0.100	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	7.944946e-01	0.100	0	0
TBC/RABGAPs	R-HSA-8854214	7.944946e-01	0.100	0	0
Regulation of Apoptosis	R-HSA-169911	7.972700e-01	0.098	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	7.972700e-01	0.098	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	7.996890e-01	0.097	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	8.018335e-01	0.096	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	8.018335e-01	0.096	0	0
PKA activation	R-HSA-163615	8.018335e-01	0.096	0	0
FGFR1 ligand binding and activation	R-HSA-190242	8.018335e-01	0.096	0	0
PKA activation in glucagon signalling	R-HSA-164378	8.018335e-01	0.096	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	8.018335e-01	0.096	0	0
Tie2 Signaling	R-HSA-210993	8.018335e-01	0.096	0	0
Vitamin D (calciferol) metabolism	R-HSA-196791	8.018335e-01	0.096	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	8.018335e-01	0.096	0	0
Platelet sensitization by LDL	R-HSA-432142	8.018335e-01	0.096	0	0
Interleukin-12 family signaling	R-HSA-447115	8.026588e-01	0.095	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.044093e-01	0.095	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.044093e-01	0.095	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	8.044093e-01	0.095	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	8.044093e-01	0.095	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.058236e-01	0.094	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	8.065400e-01	0.093	0	0
Signaling by PDGF	R-HSA-186797	8.068010e-01	0.093	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.068010e-01	0.093	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.068010e-01	0.093	0	0
Circadian clock	R-HSA-9909396	8.075914e-01	0.093	0	0
Proteasome assembly	R-HSA-9907900	8.078484e-01	0.093	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.082652e-01	0.092	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	8.088088e-01	0.092	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	8.117288e-01	0.091	0	0
Glycosphingolipid transport	R-HSA-9845576	8.117288e-01	0.091	0	0
RUNX2 regulates bone development	R-HSA-8941326	8.117288e-01	0.091	0	0
2-LTR circle formation	R-HSA-164843	8.171797e-01	0.088	0	0
DNA replication initiation	R-HSA-68952	8.171797e-01	0.088	0	0
Folding of actin by CCT/TriC	R-HSA-390450	8.171797e-01	0.088	0	0
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.171797e-01	0.088	0	0
Metabolism of serotonin	R-HSA-380612	8.171797e-01	0.088	0	0
Formation of intermediate mesoderm	R-HSA-9761174	8.171797e-01	0.088	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	8.171797e-01	0.088	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	8.171797e-01	0.088	0	0
Arachidonate production from DAG	R-HSA-426048	8.171797e-01	0.088	0	0
Pexophagy	R-HSA-9664873	8.171797e-01	0.088	0	0
Maturation of spike protein	R-HSA-9683686	8.171797e-01	0.088	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	8.171797e-01	0.088	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	8.171797e-01	0.088	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	8.171797e-01	0.088	0	0
Peptide hormone biosynthesis	R-HSA-209952	8.171797e-01	0.088	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	8.178999e-01	0.087	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.183557e-01	0.087	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.184963e-01	0.087	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	8.184963e-01	0.087	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	8.201386e-01	0.086	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.201386e-01	0.086	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.201386e-01	0.086	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	8.204564e-01	0.086	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	8.204564e-01	0.086	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	8.204564e-01	0.086	0	0
Other interleukin signaling	R-HSA-449836	8.204564e-01	0.086	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.204564e-01	0.086	0	0
STING mediated induction of host immune responses	R-HSA-1834941	8.204564e-01	0.086	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.205023e-01	0.086	0	0
Fanconi Anemia Pathway	R-HSA-6783310	8.205023e-01	0.086	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.205023e-01	0.086	0	0
Insulin receptor signalling cascade	R-HSA-74751	8.284591e-01	0.082	0	0
Ion transport by P-type ATPases	R-HSA-936837	8.284591e-01	0.082	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.295935e-01	0.081	0	0
Adaptive Immune System	R-HSA-1280218	8.303641e-01	0.081	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	8.319609e-01	0.080	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	8.324755e-01	0.080	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	8.324755e-01	0.080	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	8.347766e-01	0.078	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	8.347766e-01	0.078	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	8.374929e-01	0.077	0	0
Nephrin family interactions	R-HSA-373753	8.374929e-01	0.077	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.381107e-01	0.077	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.393153e-01	0.076	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	8.395896e-01	0.076	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.395896e-01	0.076	0	0
FGFR2b ligand binding and activation	R-HSA-190377	8.395896e-01	0.076	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	8.395896e-01	0.076	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.395896e-01	0.076	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	8.395896e-01	0.076	0	0
Bicarbonate transporters	R-HSA-425381	8.395896e-01	0.076	0	0
Transport of RCbl within the body	R-HSA-9758890	8.395896e-01	0.076	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.395896e-01	0.076	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.395896e-01	0.076	0	0
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	8.395896e-01	0.076	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.395896e-01	0.076	0	0
PECAM1 interactions	R-HSA-210990	8.395896e-01	0.076	0	0
Prostanoid ligand receptors	R-HSA-391908	8.395896e-01	0.076	0	0
Signaling by TGFB family members	R-HSA-9006936	8.396710e-01	0.076	0	0
Signaling by FGFR	R-HSA-190236	8.406873e-01	0.075	0	0
Cellular response to chemical stress	R-HSA-9711123	8.437200e-01	0.074	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.437886e-01	0.074	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	8.437886e-01	0.074	0	0
Recycling pathway of L1	R-HSA-437239	8.437886e-01	0.074	0	0
Neutrophil degranulation	R-HSA-6798695	8.469516e-01	0.072	0	0
Protein ubiquitination	R-HSA-8852135	8.471704e-01	0.072	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	8.483760e-01	0.071	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	8.483760e-01	0.071	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	8.500957e-01	0.071	0	0
Regulation of CDH1 Function	R-HSA-9764561	8.503949e-01	0.070	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	8.530519e-01	0.069	0	0
Lagging Strand Synthesis	R-HSA-69186	8.530519e-01	0.069	0	0
ERK/MAPK targets	R-HSA-198753	8.530519e-01	0.069	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	8.530519e-01	0.069	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	8.530519e-01	0.069	0	0
Basigin interactions	R-HSA-210991	8.530519e-01	0.069	0	0
Ribosome-associated quality control	R-HSA-9948299	8.573308e-01	0.067	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	8.592537e-01	0.066	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.592537e-01	0.066	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.592537e-01	0.066	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	8.592537e-01	0.066	0	0
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.592537e-01	0.066	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	8.592537e-01	0.066	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.592537e-01	0.066	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	8.592537e-01	0.066	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.592537e-01	0.066	0	0
Integration of provirus	R-HSA-162592	8.592537e-01	0.066	0	0
Uptake of dietary cobalamins into enterocytes	R-HSA-9758881	8.592537e-01	0.066	0	0
Developmental Cell Lineages	R-HSA-9734767	8.599714e-01	0.066	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.609903e-01	0.065	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	8.609903e-01	0.065	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	8.613202e-01	0.065	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	8.613202e-01	0.065	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.613202e-01	0.065	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.633368e-01	0.064	0	0
Regulated Necrosis	R-HSA-5218859	8.659896e-01	0.062	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	8.672396e-01	0.062	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	8.690721e-01	0.061	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.718179e-01	0.060	0	0
Maturation of spike protein	R-HSA-9694548	8.718179e-01	0.060	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.718179e-01	0.060	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.726733e-01	0.059	0	0
Toll-like Receptor Cascades	R-HSA-168898	8.756034e-01	0.058	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	8.765083e-01	0.057	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	8.765083e-01	0.057	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	8.765083e-01	0.057	0	0
Scavenging by Class F Receptors	R-HSA-3000484	8.765083e-01	0.057	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	8.765083e-01	0.057	0	0
IRAK1 recruits IKK complex	R-HSA-937039	8.765083e-01	0.057	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.765083e-01	0.057	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	8.765083e-01	0.057	0	0
MET activates RAS signaling	R-HSA-8851805	8.765083e-01	0.057	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	8.765083e-01	0.057	0	0
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	8.765083e-01	0.057	0	0
Diseases associated with surfactant metabolism	R-HSA-5687613	8.765083e-01	0.057	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.765083e-01	0.057	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.765083e-01	0.057	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	8.801583e-01	0.055	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	8.801583e-01	0.055	0	0
Fructose metabolism	R-HSA-5652084	8.801583e-01	0.055	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	8.801583e-01	0.055	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.816226e-01	0.055	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.816226e-01	0.055	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	8.816226e-01	0.055	0	0
Translation of Structural Proteins	R-HSA-9683701	8.816226e-01	0.055	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.828917e-01	0.054	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	8.828917e-01	0.054	0	0
The phototransduction cascade	R-HSA-2514856	8.828917e-01	0.054	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	8.834781e-01	0.054	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.834781e-01	0.054	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	8.868161e-01	0.052	0	0
Signaling by MET	R-HSA-6806834	8.868161e-01	0.052	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	8.876980e-01	0.052	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.894799e-01	0.051	0	0
COPI-mediated anterograde transport	R-HSA-6807878	8.904644e-01	0.050	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	8.912483e-01	0.050	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	8.912483e-01	0.050	0	0
FGFR2c ligand binding and activation	R-HSA-190375	8.916485e-01	0.050	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.916485e-01	0.050	0	0
FGFR4 ligand binding and activation	R-HSA-190322	8.916485e-01	0.050	0	0
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	8.916485e-01	0.050	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	8.916485e-01	0.050	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	8.916485e-01	0.050	0	0
Acetylcholine binding and downstream events	R-HSA-181431	8.916485e-01	0.050	0	0
Chylomicron remodeling	R-HSA-8963901	8.916485e-01	0.050	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	8.916485e-01	0.050	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.916485e-01	0.050	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	8.916485e-01	0.050	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	8.916485e-01	0.050	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	8.916485e-01	0.050	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.916485e-01	0.050	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	8.916485e-01	0.050	0	0
Interleukin-6 signaling	R-HSA-1059683	8.916485e-01	0.050	0	0
ER-Phagosome pathway	R-HSA-1236974	8.916848e-01	0.050	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	8.919059e-01	0.050	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	8.919059e-01	0.050	0	0
Growth hormone receptor signaling	R-HSA-982772	8.919059e-01	0.050	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	8.934122e-01	0.049	0	0
Mitochondrial protein import	R-HSA-1268020	8.934122e-01	0.049	0	0
Acyl chain remodelling of PC	R-HSA-1482788	8.934573e-01	0.049	0	0
Vpu mediated degradation of CD4	R-HSA-180534	8.934573e-01	0.049	0	0
Miscellaneous transport and binding events	R-HSA-5223345	8.934573e-01	0.049	0	0
GPCR downstream signalling	R-HSA-388396	8.951569e-01	0.048	0	0
Base Excision Repair	R-HSA-73884	8.979552e-01	0.047	0	0
Cellular responses to stress	R-HSA-2262752	8.985499e-01	0.046	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	8.990855e-01	0.046	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.992890e-01	0.046	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.006185e-01	0.045	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.025753e-01	0.045	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.025753e-01	0.045	0	0
TNFs bind their physiological receptors	R-HSA-5669034	9.025753e-01	0.045	0	0
Plasma lipoprotein assembly	R-HSA-8963898	9.025753e-01	0.045	0	0
Nuclear import of Rev protein	R-HSA-180746	9.026621e-01	0.044	0	0
Signal amplification	R-HSA-392518	9.026621e-01	0.044	0	0
RA biosynthesis pathway	R-HSA-5365859	9.026621e-01	0.044	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	9.026621e-01	0.044	0	0
G alpha (s) signalling events	R-HSA-418555	9.036426e-01	0.044	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.049332e-01	0.043	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	9.049332e-01	0.043	0	0
FGFR3c ligand binding and activation	R-HSA-190372	9.049332e-01	0.043	0	0
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	9.049332e-01	0.043	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.049332e-01	0.043	0	0
Malate-aspartate shuttle	R-HSA-9856872	9.049332e-01	0.043	0	0
Ciprofloxacin ADME	R-HSA-9793528	9.049332e-01	0.043	0	0
Signaling by NOTCH	R-HSA-157118	9.056807e-01	0.043	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.064277e-01	0.043	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	9.064786e-01	0.043	0	0
Signaling by NOTCH4	R-HSA-9013694	9.094057e-01	0.041	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.111421e-01	0.040	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.111421e-01	0.040	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.111421e-01	0.040	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.111421e-01	0.040	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.122542e-01	0.040	0	0
Laminin interactions	R-HSA-3000157	9.122542e-01	0.040	0	0
Glycolysis	R-HSA-70171	9.131110e-01	0.039	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.145874e-01	0.039	0	0
Somitogenesis	R-HSA-9824272	9.145874e-01	0.039	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.149698e-01	0.039	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.153245e-01	0.038	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.158952e-01	0.038	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	9.165898e-01	0.038	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	9.165898e-01	0.038	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	9.165898e-01	0.038	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.165898e-01	0.038	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	9.165898e-01	0.038	0	0
Signaling by Activin	R-HSA-1502540	9.165898e-01	0.038	0	0
FGFR3 ligand binding and activation	R-HSA-190239	9.165898e-01	0.038	0	0
DNA Damage Reversal	R-HSA-73942	9.165898e-01	0.038	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.189452e-01	0.037	0	0
Triglyceride catabolism	R-HSA-163560	9.189452e-01	0.037	0	0
Cellular response to starvation	R-HSA-9711097	9.189555e-01	0.037	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.200770e-01	0.036	0	0
Mitochondrial biogenesis	R-HSA-1592230	9.202308e-01	0.036	0	0
Glucose metabolism	R-HSA-70326	9.202308e-01	0.036	0	0
UCH proteinases	R-HSA-5689603	9.209064e-01	0.036	0	0
Myogenesis	R-HSA-525793	9.210250e-01	0.036	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.210250e-01	0.036	0	0
Abacavir ADME	R-HSA-2161522	9.210250e-01	0.036	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.210250e-01	0.036	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.214298e-01	0.036	0	0
Potential therapeutics for SARS	R-HSA-9679191	9.227345e-01	0.035	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	9.228649e-01	0.035	0	0
Cellular responses to stimuli	R-HSA-8953897	9.236857e-01	0.034	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.254017e-01	0.034	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.261175e-01	0.033	0	0
Degradation of AXIN	R-HSA-4641257	9.261175e-01	0.033	0	0
Translation of Structural Proteins	R-HSA-9694635	9.261661e-01	0.033	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	9.268177e-01	0.033	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	9.268177e-01	0.033	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	9.268177e-01	0.033	0	0
Activation of SMO	R-HSA-5635838	9.268177e-01	0.033	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	9.268177e-01	0.033	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	9.268177e-01	0.033	0	0
Atorvastatin ADME	R-HSA-9754706	9.268177e-01	0.033	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	9.276182e-01	0.033	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.277760e-01	0.033	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.289649e-01	0.032	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	9.289649e-01	0.032	0	0
Triglyceride biosynthesis	R-HSA-75109	9.289649e-01	0.032	0	0
Synthesis of PE	R-HSA-1483213	9.289649e-01	0.032	0	0
Signaling by BMP	R-HSA-201451	9.289649e-01	0.032	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	9.289649e-01	0.032	0	0
Neddylation	R-HSA-8951664	9.293459e-01	0.032	0	0
Vesicle-mediated transport	R-HSA-5653656	9.305701e-01	0.031	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.306778e-01	0.031	0	0
Intraflagellar transport	R-HSA-5620924	9.336559e-01	0.030	0	0
Metal ion SLC transporters	R-HSA-425410	9.336559e-01	0.030	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	9.357920e-01	0.029	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.357920e-01	0.029	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.357920e-01	0.029	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.357920e-01	0.029	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.357920e-01	0.029	0	0
Vitamin B6 activation to pyridoxal phosphate	R-HSA-964975	9.357920e-01	0.029	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.357920e-01	0.029	0	0
Coenzyme A biosynthesis	R-HSA-196783	9.357920e-01	0.029	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.357920e-01	0.029	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	9.357920e-01	0.029	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.357920e-01	0.029	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.361458e-01	0.029	0	0
Pyroptosis	R-HSA-5620971	9.361458e-01	0.029	0	0
Triglyceride metabolism	R-HSA-8979227	9.365354e-01	0.028	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.365354e-01	0.028	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	9.369243e-01	0.028	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	9.387434e-01	0.027	0	0
RAS processing	R-HSA-9648002	9.387434e-01	0.027	0	0
Nucleotide Excision Repair	R-HSA-5696398	9.395902e-01	0.027	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.413942e-01	0.026	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.426342e-01	0.026	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.426342e-01	0.026	0	0
Regulation of gene expression in beta cells	R-HSA-210745	9.426342e-01	0.026	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.436662e-01	0.025	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.436662e-01	0.025	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	9.436662e-01	0.025	0	0
Glycogen storage diseases	R-HSA-3229121	9.436662e-01	0.025	0	0
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	9.436662e-01	0.025	0	0
Catecholamine biosynthesis	R-HSA-209905	9.436662e-01	0.025	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.436662e-01	0.025	0	0
GDP-fucose biosynthesis	R-HSA-6787639	9.436662e-01	0.025	0	0
Choline catabolism	R-HSA-6798163	9.436662e-01	0.025	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	9.442786e-01	0.025	0	0
Neurotransmitter release cycle	R-HSA-112310	9.446506e-01	0.025	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.448526e-01	0.025	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.459152e-01	0.024	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.460537e-01	0.024	0	0
Gene Silencing by RNA	R-HSA-211000	9.467008e-01	0.024	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	9.484921e-01	0.023	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.484921e-01	0.023	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.484921e-01	0.023	0	0
Neurotransmitter clearance	R-HSA-112311	9.484921e-01	0.023	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	9.493460e-01	0.023	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.493460e-01	0.023	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.493460e-01	0.023	0	0
Gastrulation	R-HSA-9758941	9.494665e-01	0.023	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.499726e-01	0.022	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.502826e-01	0.022	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	9.505752e-01	0.022	0	0
Activated point mutants of FGFR2	R-HSA-2033519	9.505752e-01	0.022	0	0
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	9.505752e-01	0.022	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.505752e-01	0.022	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.505752e-01	0.022	0	0
Nephron development	R-HSA-9831926	9.505752e-01	0.022	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.505752e-01	0.022	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.517432e-01	0.021	0	0
IRE1alpha activates chaperones	R-HSA-381070	9.517570e-01	0.021	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	9.537765e-01	0.021	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	9.537765e-01	0.021	0	0
Cargo concentration in the ER	R-HSA-5694530	9.537765e-01	0.021	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.537765e-01	0.021	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.537765e-01	0.021	0	0
Intra-Golgi traffic	R-HSA-6811438	9.539810e-01	0.020	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	9.551339e-01	0.020	0	0
Pyrimidine biosynthesis	R-HSA-500753	9.566372e-01	0.019	0	0
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	9.566372e-01	0.019	0	0
Diseases of hemostasis	R-HSA-9671793	9.566372e-01	0.019	0	0
rRNA processing	R-HSA-72312	9.567769e-01	0.019	0	0
Amino acids regulate mTORC1	R-HSA-9639288	9.570331e-01	0.019	0	0
Influenza Infection	R-HSA-168255	9.576659e-01	0.019	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.582169e-01	0.019	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	9.585399e-01	0.018	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.592148e-01	0.018	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.604038e-01	0.018	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.619559e-01	0.017	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.619559e-01	0.017	0	0
Glycogen synthesis	R-HSA-3322077	9.619559e-01	0.017	0	0
Negative regulation of MET activity	R-HSA-6807004	9.619559e-01	0.017	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.619559e-01	0.017	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.619559e-01	0.017	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	9.619559e-01	0.017	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.620849e-01	0.017	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	9.628305e-01	0.016	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.638126e-01	0.016	0	0
PPARA activates gene expression	R-HSA-1989781	9.638187e-01	0.016	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.640405e-01	0.016	0	0
Signaling by NOTCH3	R-HSA-9012852	9.640405e-01	0.016	0	0
Surfactant metabolism	R-HSA-5683826	9.656140e-01	0.015	0	0
FGFR2 ligand binding and activation	R-HSA-190241	9.666226e-01	0.015	0	0
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.666226e-01	0.015	0	0
Acyl chain remodelling of PG	R-HSA-1482925	9.666226e-01	0.015	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.666226e-01	0.015	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.666226e-01	0.015	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.666226e-01	0.015	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.666226e-01	0.015	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	9.666226e-01	0.015	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	9.666927e-01	0.015	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	9.666927e-01	0.015	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.666927e-01	0.015	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.671313e-01	0.015	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.671313e-01	0.015	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.688317e-01	0.014	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.688317e-01	0.014	0	0
Dectin-2 family	R-HSA-5621480	9.699730e-01	0.013	0	0
Synthesis of PA	R-HSA-1483166	9.699730e-01	0.013	0	0
Dual Incision in GG-NER	R-HSA-5696400	9.701669e-01	0.013	0	0
Signaling by NOTCH2	R-HSA-1980145	9.701669e-01	0.013	0	0
Host Interactions of HIV factors	R-HSA-162909	9.706018e-01	0.013	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	9.707171e-01	0.013	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.707171e-01	0.013	0	0
Attachment and Entry	R-HSA-9694614	9.707171e-01	0.013	0	0
Molybdenum cofactor biosynthesis	R-HSA-947581	9.707171e-01	0.013	0	0
Glutathione synthesis and recycling	R-HSA-174403	9.707171e-01	0.013	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.723001e-01	0.012	0	0
PKR-mediated signaling	R-HSA-9833482	9.725412e-01	0.012	0	0
Dual incision in TC-NER	R-HSA-6782135	9.725836e-01	0.012	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	9.732903e-01	0.012	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.732903e-01	0.012	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	9.743095e-01	0.011	0	0
Biosynthesis of D-series resolvins	R-HSA-9018676	9.743095e-01	0.011	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.743095e-01	0.011	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.743095e-01	0.011	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.743095e-01	0.011	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.749803e-01	0.011	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.765244e-01	0.010	0	0
GPER1 signaling	R-HSA-9634597	9.768598e-01	0.010	0	0
Gluconeogenesis	R-HSA-70263	9.768598e-01	0.010	0	0
GABA receptor activation	R-HSA-977443	9.771792e-01	0.010	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.771792e-01	0.010	0	0
HIV Infection	R-HSA-162906	9.774092e-01	0.010	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.774613e-01	0.010	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.774613e-01	0.010	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.774613e-01	0.010	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.774613e-01	0.010	0	0
Mitochondrial mRNA modification	R-HSA-9937008	9.774613e-01	0.010	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	9.774613e-01	0.010	0	0
ABC transporters in lipid homeostasis	R-HSA-1369062	9.774613e-01	0.010	0	0
Biosynthesis of maresins	R-HSA-9018682	9.774613e-01	0.010	0	0
G alpha (q) signalling events	R-HSA-416476	9.776852e-01	0.010	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.784751e-01	0.009	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	9.785539e-01	0.009	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	9.786165e-01	0.009	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	9.786165e-01	0.009	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.786165e-01	0.009	0	0
NCAM1 interactions	R-HSA-419037	9.786165e-01	0.009	0	0
Collagen chain trimerization	R-HSA-8948216	9.786165e-01	0.009	0	0
Signaling by Insulin receptor	R-HSA-74752	9.789500e-01	0.009	0	0
DNA Damage Bypass	R-HSA-73893	9.790673e-01	0.009	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	9.791952e-01	0.009	0	0
Aquaporin-mediated transport	R-HSA-445717	9.791952e-01	0.009	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	9.802267e-01	0.009	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	9.802267e-01	0.009	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.802267e-01	0.009	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.802267e-01	0.009	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.802267e-01	0.009	0	0
Mitochondrial RNA degradation	R-HSA-9836573	9.802267e-01	0.009	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.802267e-01	0.009	0	0
Interleukin-6 family signaling	R-HSA-6783589	9.802267e-01	0.009	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.806534e-01	0.008	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	9.808781e-01	0.008	0	0
Phospholipid metabolism	R-HSA-1483257	9.813016e-01	0.008	0	0
Signaling by GPCR	R-HSA-372790	9.815524e-01	0.008	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	9.816742e-01	0.008	0	0
Collagen formation	R-HSA-1474290	9.820102e-01	0.008	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	9.826529e-01	0.008	0	0
G protein gated Potassium channels	R-HSA-1296059	9.826529e-01	0.008	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.826529e-01	0.008	0	0
Alpha-oxidation of phytanate	R-HSA-389599	9.826529e-01	0.008	0	0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	9.826529e-01	0.008	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.826529e-01	0.008	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.826529e-01	0.008	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.829068e-01	0.007	0	0
Hemostasis	R-HSA-109582	9.831416e-01	0.007	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.847257e-01	0.007	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	9.847257e-01	0.007	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.847815e-01	0.007	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	9.847815e-01	0.007	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	9.847815e-01	0.007	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.847815e-01	0.007	0	0
Sphingolipid catabolism	R-HSA-9845614	9.847815e-01	0.007	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.859791e-01	0.006	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	9.863557e-01	0.006	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.866490e-01	0.006	0	0
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	9.866490e-01	0.006	0	0
Insulin processing	R-HSA-264876	9.866490e-01	0.006	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	9.867924e-01	0.006	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.867924e-01	0.006	0	0
Heme biosynthesis	R-HSA-189451	9.878159e-01	0.005	0	0
Prednisone ADME	R-HSA-9757110	9.882875e-01	0.005	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.884094e-01	0.005	0	0
G alpha (z) signalling events	R-HSA-418597	9.886365e-01	0.005	0	0
SARS-CoV Infections	R-HSA-9679506	9.887521e-01	0.005	0	0
Platelet degranulation	R-HSA-114608	9.889029e-01	0.005	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.891232e-01	0.005	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.891232e-01	0.005	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.892513e-01	0.005	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	9.893895e-01	0.005	0	0
Thyroxine biosynthesis	R-HSA-209968	9.897250e-01	0.004	0	0
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.897250e-01	0.004	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.897250e-01	0.004	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.897514e-01	0.004	0	0
Defensins	R-HSA-1461973	9.902933e-01	0.004	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.903069e-01	0.004	0	0
HIV Life Cycle	R-HSA-162587	9.905186e-01	0.004	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.906046e-01	0.004	0	0
Leishmania infection	R-HSA-9658195	9.906046e-01	0.004	0	0
HCMV Early Events	R-HSA-9609690	9.906444e-01	0.004	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	9.909861e-01	0.004	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.913401e-01	0.004	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.916734e-01	0.004	0	0
Retinoid metabolism and transport	R-HSA-975634	9.919526e-01	0.004	0	0
Leishmania phagocytosis	R-HSA-9664417	9.920478e-01	0.003	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.920478e-01	0.003	0	0
Parasite infection	R-HSA-9664407	9.920478e-01	0.003	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.920925e-01	0.003	0	0
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	9.920925e-01	0.003	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.920925e-01	0.003	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.920925e-01	0.003	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	9.922762e-01	0.003	0	0
Regulation of beta-cell development	R-HSA-186712	9.924988e-01	0.003	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.928477e-01	0.003	0	0
HS-GAG degradation	R-HSA-2024096	9.930631e-01	0.003	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	9.931131e-01	0.003	0	0
Metabolism of polyamines	R-HSA-351202	9.932447e-01	0.003	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.938609e-01	0.003	0	0
Synthesis of PC	R-HSA-1483191	9.938609e-01	0.003	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.939147e-01	0.003	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.942008e-01	0.003	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.945585e-01	0.002	0	0
Iron uptake and transport	R-HSA-917937	9.945585e-01	0.002	0	0
Heme degradation	R-HSA-189483	9.946617e-01	0.002	0	0
Chaperonin-mediated protein folding	R-HSA-390466	9.949094e-01	0.002	0	0
SARS-CoV-2 Infection	R-HSA-9694516	9.949503e-01	0.002	0	0
Complex I biogenesis	R-HSA-6799198	9.950764e-01	0.002	0	0
Gap junction trafficking and regulation	R-HSA-157858	9.951256e-01	0.002	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.953171e-01	0.002	0	0
eNOS activation	R-HSA-203615	9.953171e-01	0.002	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.953171e-01	0.002	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.953171e-01	0.002	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.953171e-01	0.002	0	0
Hyaluronan metabolism	R-HSA-2142845	9.953171e-01	0.002	0	0
Gap junction assembly	R-HSA-190861	9.953171e-01	0.002	0	0
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.953171e-01	0.002	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.953171e-01	0.002	0	0
PERK regulates gene expression	R-HSA-381042	9.958921e-01	0.002	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.958921e-01	0.002	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.958921e-01	0.002	0	0
ABC transporter disorders	R-HSA-5619084	9.959577e-01	0.002	0	0
Cholesterol biosynthesis	R-HSA-191273	9.959577e-01	0.002	0	0
Interleukin-10 signaling	R-HSA-6783783	9.959577e-01	0.002	0	0
Integrin cell surface interactions	R-HSA-216083	9.959577e-01	0.002	0	0
Interferon gamma signaling	R-HSA-877300	9.960244e-01	0.002	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.961560e-01	0.002	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.963415e-01	0.002	0	0
HS-GAG biosynthesis	R-HSA-2022928	9.963965e-01	0.002	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.963965e-01	0.002	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.964219e-01	0.002	0	0
Interferon Signaling	R-HSA-913531	9.964772e-01	0.002	0	0
Inositol phosphate metabolism	R-HSA-1483249	9.965809e-01	0.001	0	0
Metabolism of steroid hormones	R-HSA-196071	9.967850e-01	0.001	0	0
Nicotinate metabolism	R-HSA-196807	9.967850e-01	0.001	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.968390e-01	0.001	0	0
Lysine catabolism	R-HSA-71064	9.968390e-01	0.001	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.969360e-01	0.001	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.970062e-01	0.001	0	0
Protein folding	R-HSA-391251	9.971100e-01	0.001	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.972272e-01	0.001	0	0
Purine salvage	R-HSA-74217	9.972272e-01	0.001	0	0
Elastic fibre formation	R-HSA-1566948	9.972272e-01	0.001	0	0
Immune System	R-HSA-168256	9.972334e-01	0.001	0	0
RSV-host interactions	R-HSA-9833110	9.975584e-01	0.001	0	0
Pentose phosphate pathway	R-HSA-71336	9.975677e-01	0.001	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.975677e-01	0.001	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.976718e-01	0.001	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.978662e-01	0.001	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.978664e-01	0.001	0	0
Tryptophan catabolism	R-HSA-71240	9.978664e-01	0.001	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.978664e-01	0.001	0	0
ECM proteoglycans	R-HSA-3000178	9.979105e-01	0.001	0	0
Metabolism of cofactors	R-HSA-8978934	9.979105e-01	0.001	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.981285e-01	0.001	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.981358e-01	0.001	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.982935e-01	0.001	0	0
G alpha (i) signalling events	R-HSA-418594	9.983613e-01	0.001	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.983716e-01	0.001	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	9.984217e-01	0.001	0	0
Pyruvate metabolism	R-HSA-70268	9.985302e-01	0.001	0	0
Activation of GABAB receptors	R-HSA-991365	9.985600e-01	0.001	0	0
GABA B receptor activation	R-HSA-977444	9.985600e-01	0.001	0	0
RAB geranylgeranylation	R-HSA-8873719	9.986516e-01	0.001	0	0
tRNA Aminoacylation	R-HSA-379724	9.986516e-01	0.001	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.987363e-01	0.001	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.987369e-01	0.001	0	0
Collagen degradation	R-HSA-1442490	9.988017e-01	0.001	0	0
Protein localization	R-HSA-9609507	9.988357e-01	0.001	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.988921e-01	0.000	0	0
Gap junction trafficking	R-HSA-190828	9.988921e-01	0.000	0	0
tRNA processing in the nucleus	R-HSA-6784531	9.989353e-01	0.000	0	0
Formation of the cornified envelope	R-HSA-6809371	9.990145e-01	0.000	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.990282e-01	0.000	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.991476e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.992641e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.992761e-01	0.000	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.993442e-01	0.000	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.994248e-01	0.000	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.994248e-01	0.000	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.994780e-01	0.000	0	0
Azathioprine ADME	R-HSA-9748787	9.994955e-01	0.000	0	0
HCMV Infection	R-HSA-9609646	9.995362e-01	0.000	0	0
Complex IV assembly	R-HSA-9864848	9.995575e-01	0.000	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.995889e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.996082e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.996352e-01	0.000	0	0
SLC transporter disorders	R-HSA-5619102	9.996405e-01	0.000	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.996764e-01	0.000	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.996890e-01	0.000	0	0
HCMV Late Events	R-HSA-9610379	9.996925e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.997130e-01	0.000	0	0
Paracetamol ADME	R-HSA-9753281	9.997381e-01	0.000	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.997454e-01	0.000	0	0
Digestion	R-HSA-8935690	9.997703e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.997714e-01	0.000	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.998371e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.998383e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.998427e-01	0.000	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.998450e-01	0.000	0	0
Peroxisomal protein import	R-HSA-9033241	9.998450e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.998545e-01	0.000	0	0
Glutathione conjugation	R-HSA-156590	9.998641e-01	0.000	0	0
Endogenous sterols	R-HSA-211976	9.998808e-01	0.000	0	0
Nucleotide salvage	R-HSA-8956321	9.998808e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999077e-01	0.000	0	0
Digestion and absorption	R-HSA-8963743	9.999083e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999157e-01	0.000	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.999196e-01	0.000	0	0
Xenobiotics	R-HSA-211981	9.999196e-01	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.999295e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.999338e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999338e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.999458e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999526e-01	0.000	0	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999586e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999671e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999696e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999707e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.999719e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999753e-01	0.000	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999810e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999819e-01	0.000	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.999822e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999856e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999878e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999888e-01	0.000	0	0
Viral Infection Pathways	R-HSA-9824446	9.999888e-01	0.000	0	0
Translation	R-HSA-72766	9.999896e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999903e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999905e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999914e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.999916e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999942e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999945e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999948e-01	0.000	0	0
Classical antibody-mediated complement activation	R-HSA-173623	9.999970e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999978e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999978e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.999980e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.999981e-01	0.000	0	0
tRNA processing	R-HSA-72306	9.999984e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999990e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.999991e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.999994e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999996e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999996e-01	0.000	0	0
Creation of C4 and C2 activators	R-HSA-166786	9.999998e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999999e-01	0.000	0	0
Complement cascade	R-HSA-166658	9.999999e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999999e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999999e-01	0.000	0	0
Initial triggering of complement	R-HSA-166663	9.999999e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999999e-01	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000	0	0
Post-translational protein modification	R-HSA-597592	1.000000e+00	0.000	1	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	1.000000e+00	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Disease	R-HSA-1643685	1.000000e+00	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	1	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cell Cycle	R-HSA-1640170	4.440892e-16	15.353	1	0
M Phase	R-HSA-68886	1.554312e-15	14.808	1	0
Cell Cycle, Mitotic	R-HSA-69278	1.465494e-14	13.834	1	0
Cell Cycle Checkpoints	R-HSA-69620	3.030909e-14	13.518	1	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	5.899725e-13	12.229	0	0
Mitotic Prophase	R-HSA-68875	1.295852e-12	11.887	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	6.024736e-12	11.220	0	0
Chromatin organization	R-HSA-4839726	1.593925e-11	10.798	0	0
Chromatin modifying enzymes	R-HSA-3247509	4.327727e-11	10.364	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	5.403178e-11	10.267	0	0
HATs acetylate histones	R-HSA-3214847	3.190151e-10	9.496	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.951534e-10	9.305	0	0
Cellular Senescence	R-HSA-2559583	5.505622e-10	9.259	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	6.547343e-10	9.184	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	6.547043e-10	9.184	0	0
PRC2 methylates histones and DNA	R-HSA-212300	8.469190e-10	9.072	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	8.562061e-10	9.067	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	8.458617e-10	9.073	0	0
Assembly of the pre-replicative complex	R-HSA-68867	1.007496e-09	8.997	0	0
DNA methylation	R-HSA-5334118	1.254452e-09	8.902	0	0
G2/M Checkpoints	R-HSA-69481	1.225266e-09	8.912	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	1.378897e-09	8.860	0	0
Cellular responses to stress	R-HSA-2262752	1.698282e-09	8.770	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	2.350332e-09	8.629	0	0
Meiotic synapsis	R-HSA-1221632	2.479478e-09	8.606	0	0
Metabolism of RNA	R-HSA-8953854	2.868836e-09	8.542	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.993183e-09	8.524	0	0
DNA Replication Pre-Initiation	R-HSA-69002	3.215415e-09	8.493	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	3.492476e-09	8.457	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.961122e-09	8.402	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	4.326764e-09	8.364	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	5.043782e-09	8.297	0	0
Signal Transduction	R-HSA-162582	6.774238e-09	8.169	1	0
Apoptotic execution phase	R-HSA-75153	7.144589e-09	8.146	0	0
G2/M DNA damage checkpoint	R-HSA-69473	7.840702e-09	8.106	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	8.347772e-09	8.078	0	0
Mitotic Anaphase	R-HSA-68882	1.253635e-08	7.902	1	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.259255e-08	7.900	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.423160e-08	7.847	1	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.418060e-08	7.848	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.418060e-08	7.848	0	0
Cellular responses to stimuli	R-HSA-8953897	1.510137e-08	7.821	0	0
mRNA Splicing	R-HSA-72172	1.898915e-08	7.721	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.009950e-08	7.697	0	0
HDACs deacetylate histones	R-HSA-3214815	2.082306e-08	7.681	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	2.044739e-08	7.689	0	0
Cell-Cell communication	R-HSA-1500931	2.100050e-08	7.678	0	0
DNA Double Strand Break Response	R-HSA-5693606	2.455023e-08	7.610	0	0
Meiosis	R-HSA-1500620	2.433309e-08	7.614	0	0
Estrogen-dependent gene expression	R-HSA-9018519	2.603109e-08	7.585	0	0
Cell junction organization	R-HSA-446728	2.822453e-08	7.549	0	0
Axon guidance	R-HSA-422475	3.118955e-08	7.506	0	0
Signaling by ROBO receptors	R-HSA-376176	3.899567e-08	7.409	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	3.823773e-08	7.418	0	0
Cellular response to heat stress	R-HSA-3371556	4.123536e-08	7.385	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	6.298182e-08	7.201	0	0
Nervous system development	R-HSA-9675108	6.353688e-08	7.197	0	0
Defective pyroptosis	R-HSA-9710421	7.036436e-08	7.153	0	0
Gene Silencing by RNA	R-HSA-211000	8.780897e-08	7.056	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.111799e-07	6.954	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.250175e-07	6.903	0	0
Packaging Of Telomere Ends	R-HSA-171306	1.403305e-07	6.853	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.400691e-07	6.854	0	0
Meiotic recombination	R-HSA-912446	1.428969e-07	6.845	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.779410e-07	6.750	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.930077e-07	6.714	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	2.049500e-07	6.688	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	2.649512e-07	6.577	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	3.144918e-07	6.502	0	0
Regulation of endogenous retroelements	R-HSA-9842860	3.264559e-07	6.486	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.748384e-07	6.426	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	4.063722e-07	6.391	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	4.867359e-07	6.313	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	5.206720e-07	6.283	0	0
Adherens junctions interactions	R-HSA-418990	6.435034e-07	6.191	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	6.684310e-07	6.175	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	8.051383e-07	6.094	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.051383e-07	6.094	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.035275e-06	5.985	0	0
Eukaryotic Translation Initiation	R-HSA-72613	1.603497e-06	5.795	0	0
Cap-dependent Translation Initiation	R-HSA-72737	1.603497e-06	5.795	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.575459e-06	5.803	0	0
Eukaryotic Translation Elongation	R-HSA-156842	1.648778e-06	5.783	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.918946e-06	5.717	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.919175e-06	5.717	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.919175e-06	5.717	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	2.314318e-06	5.636	1	0
DNA Replication	R-HSA-69306	2.585627e-06	5.587	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	2.673472e-06	5.573	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	3.096583e-06	5.509	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	3.096583e-06	5.509	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	3.300231e-06	5.481	0	0
RNA Polymerase I Transcription	R-HSA-73864	3.492463e-06	5.457	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	3.722104e-06	5.429	1	0
Separation of Sister Chromatids	R-HSA-2467813	3.792230e-06	5.421	1	1
Influenza Infection	R-HSA-168255	3.841040e-06	5.416	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	3.940447e-06	5.404	0	0
Amplification of signal from the kinetochores	R-HSA-141424	4.337497e-06	5.363	1	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.337497e-06	5.363	1	1
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.402004e-06	5.356	0	0
Cleavage of the damaged purine	R-HSA-110331	4.665343e-06	5.331	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	4.998900e-06	5.301	0	0
Depyrimidination	R-HSA-73928	4.998900e-06	5.301	0	0
Gene expression (Transcription)	R-HSA-74160	5.366319e-06	5.270	1	0
Programmed Cell Death	R-HSA-5357801	5.077511e-06	5.294	0	0
Amyloid fiber formation	R-HSA-977225	5.933342e-06	5.227	0	0
Depurination	R-HSA-73927	6.071808e-06	5.217	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	6.705008e-06	5.174	0	0
ISG15 antiviral mechanism	R-HSA-1169408	6.785241e-06	5.168	0	0
Diseases of programmed cell death	R-HSA-9645723	7.136456e-06	5.147	0	0
Cell-cell junction organization	R-HSA-421270	7.429718e-06	5.129	0	0
Apoptosis	R-HSA-109581	7.487018e-06	5.126	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	7.844164e-06	5.105	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.098019e-06	5.092	0	0
Epigenetic regulation of gene expression	R-HSA-212165	8.813869e-06	5.055	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	9.281699e-06	5.032	0	0
ESR-mediated signaling	R-HSA-8939211	9.831556e-06	5.007	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.006255e-05	4.997	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.017690e-05	4.992	0	0
Nucleosome assembly	R-HSA-774815	1.017690e-05	4.992	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	1.102301e-05	4.958	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.220199e-05	4.914	0	0
mRNA 3'-end processing	R-HSA-72187	1.220199e-05	4.914	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	1.220199e-05	4.914	0	0
Reproduction	R-HSA-1474165	1.390522e-05	4.857	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.463560e-05	4.835	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.028636e-05	4.693	0	0
Signaling by WNT	R-HSA-195721	2.033570e-05	4.692	0	0
Peptide chain elongation	R-HSA-156902	2.168369e-05	4.664	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	2.170971e-05	4.663	0	0
HCMV Early Events	R-HSA-9609690	2.233914e-05	4.651	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.410731e-05	4.618	1	1
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.427654e-05	4.615	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.473808e-05	4.607	0	0
HCMV Late Events	R-HSA-9610379	2.537631e-05	4.596	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	2.801622e-05	4.553	0	0
Cell-extracellular matrix interactions	R-HSA-446353	3.153195e-05	4.501	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	3.196549e-05	4.495	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.577401e-05	4.446	0	0
Mitotic Prometaphase	R-HSA-68877	3.744537e-05	4.427	1	1
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.214609e-05	4.375	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	3.971816e-05	4.401	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	3.971816e-05	4.401	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.868947e-05	4.412	0	0
Homology Directed Repair	R-HSA-5693538	4.325366e-05	4.364	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.378383e-05	4.359	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.883260e-05	4.311	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	4.955221e-05	4.305	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.364423e-05	4.270	0	0
Developmental Biology	R-HSA-1266738	5.803887e-05	4.236	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	6.450927e-05	4.190	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.736119e-05	4.172	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	6.755823e-05	4.170	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	7.525083e-05	4.123	1	1
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.981133e-05	4.047	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	9.194120e-05	4.036	0	0
Telomere Maintenance	R-HSA-157579	1.014670e-04	3.994	0	0
RNA Polymerase II Transcription	R-HSA-73857	1.153408e-04	3.938	1	0
HSF1-dependent transactivation	R-HSA-3371571	1.263982e-04	3.898	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.271576e-04	3.896	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.307485e-04	3.884	0	0
HIV Life Cycle	R-HSA-162587	1.362054e-04	3.866	0	0
Attenuation phase	R-HSA-3371568	1.564055e-04	3.806	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.611167e-04	3.793	0	0
SARS-CoV-1 Infection	R-HSA-9678108	1.641364e-04	3.785	0	0
Nuclear import of Rev protein	R-HSA-180746	1.661868e-04	3.779	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.682724e-04	3.774	0	0
Regulation of TP53 Activity	R-HSA-5633007	1.810400e-04	3.742	1	0
SARS-CoV-2-host interactions	R-HSA-9705683	1.839048e-04	3.735	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.135267e-04	3.671	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.064684e-04	3.685	0	0
Translation initiation complex formation	R-HSA-72649	2.135834e-04	3.670	0	0
Protein ubiquitination	R-HSA-8852135	1.997209e-04	3.700	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	2.135267e-04	3.671	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.901303e-04	3.721	0	0
Signaling by NOTCH	R-HSA-157118	2.310886e-04	3.636	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.399944e-04	3.620	0	0
HCMV Infection	R-HSA-9609646	2.472447e-04	3.607	0	0
HSF1 activation	R-HSA-3371511	2.547854e-04	3.594	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.585544e-04	3.587	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.686740e-04	3.571	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.686740e-04	3.571	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.699217e-04	3.569	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	2.949193e-04	3.530	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	3.123889e-04	3.505	0	0
Metalloprotease DUBs	R-HSA-5689901	3.425151e-04	3.465	0	0
Chromosome Maintenance	R-HSA-73886	3.664847e-04	3.436	0	0
Glycolysis	R-HSA-70171	3.785698e-04	3.422	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.806657e-04	3.419	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.926944e-04	3.406	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	3.926944e-04	3.406	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	4.154769e-04	3.381	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	4.266683e-04	3.370	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	4.052553e-04	3.392	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.222289e-04	3.374	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	4.494225e-04	3.347	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	4.922443e-04	3.308	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	4.968766e-04	3.304	0	0
Signaling by Hippo	R-HSA-2028269	4.983944e-04	3.302	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	5.110274e-04	3.292	0	0
Eukaryotic Translation Termination	R-HSA-72764	5.320226e-04	3.274	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	5.555046e-04	3.255	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	5.555046e-04	3.255	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	5.920362e-04	3.228	0	0
Base Excision Repair	R-HSA-73884	5.929318e-04	3.227	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	6.567745e-04	3.183	0	0
PKMTs methylate histone lysines	R-HSA-3214841	6.655772e-04	3.177	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	6.666989e-04	3.176	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.438599e-04	3.129	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	8.305721e-04	3.081	0	0
Signaling by PTK6	R-HSA-8848021	8.463454e-04	3.072	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	8.463454e-04	3.072	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	8.649015e-04	3.063	0	0
Spry regulation of FGF signaling	R-HSA-1295596	1.023382e-03	2.990	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.023382e-03	2.990	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	8.970056e-04	3.047	0	0
Signaling by EGFR	R-HSA-177929	8.970056e-04	3.047	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	1.023382e-03	2.990	0	0
Regulation of TP53 Degradation	R-HSA-6804757	9.139413e-04	3.039	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	9.029523e-04	3.044	0	0
Signaling by ALK in cancer	R-HSA-9700206	9.029523e-04	3.044	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.023382e-03	2.990	0	0
EGFR downregulation	R-HSA-182971	1.026146e-03	2.989	0	0
Selenocysteine synthesis	R-HSA-2408557	1.027550e-03	2.988	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	1.084890e-03	2.965	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.084890e-03	2.965	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.084890e-03	2.965	0	0
Ribosome-associated quality control	R-HSA-9948299	1.092909e-03	2.961	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.095935e-03	2.960	0	0
Deubiquitination	R-HSA-5688426	1.218463e-03	2.914	0	0
Viral mRNA Translation	R-HSA-192823	1.263287e-03	2.898	0	0
Negative regulation of FLT3	R-HSA-9706369	1.368569e-03	2.864	0	0
snRNP Assembly	R-HSA-191859	1.370859e-03	2.863	0	0
Metabolism of non-coding RNA	R-HSA-194441	1.370859e-03	2.863	0	0
Membrane Trafficking	R-HSA-199991	1.381635e-03	2.860	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.436634e-03	2.843	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.436634e-03	2.843	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	1.436634e-03	2.843	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.549861e-03	2.810	0	0
Signaling by ERBB2	R-HSA-1227986	1.569142e-03	2.804	0	0
Interleukin-12 signaling	R-HSA-9020591	1.661636e-03	2.779	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.810151e-03	2.742	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.954291e-03	2.709	0	0
Oncogenic MAPK signaling	R-HSA-6802957	1.855541e-03	2.732	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.113781e-03	2.675	0	0
p75NTR recruits signalling complexes	R-HSA-209543	2.113781e-03	2.675	0	0
FLT3 Signaling	R-HSA-9607240	2.147129e-03	2.668	0	0
Generic Transcription Pathway	R-HSA-212436	1.891316e-03	2.723	1	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.147129e-03	2.668	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	2.159313e-03	2.666	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.173620e-03	2.663	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	2.173620e-03	2.663	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	2.173620e-03	2.663	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.173620e-03	2.663	0	0
Co-inhibition by PD-1	R-HSA-389948	2.299457e-03	2.638	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.302271e-03	2.638	1	1
Ub-specific processing proteases	R-HSA-5689880	2.428840e-03	2.615	0	0
Late endosomal microautophagy	R-HSA-9615710	2.497394e-03	2.603	0	0
MAP2K and MAPK activation	R-HSA-5674135	2.509125e-03	2.600	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	2.509125e-03	2.600	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	2.560707e-03	2.592	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	2.614514e-03	2.583	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.747040e-03	2.561	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	2.796664e-03	2.553	0	0
Glucose metabolism	R-HSA-70326	2.801042e-03	2.553	0	0
Regulation of CDH1 Function	R-HSA-9764561	2.889045e-03	2.539	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.918915e-03	2.535	0	0
MTOR signalling	R-HSA-165159	2.918915e-03	2.535	0	0
Switching of origins to a post-replicative state	R-HSA-69052	2.956310e-03	2.529	0	0
DNA Repair	R-HSA-73894	3.117087e-03	2.506	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	3.589579e-03	2.445	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.733650e-03	2.428	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	3.748875e-03	2.426	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	3.748875e-03	2.426	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	3.748875e-03	2.426	0	0
RMTs methylate histone arginines	R-HSA-3214858	3.899745e-03	2.409	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	4.368642e-03	2.360	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	4.368642e-03	2.360	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	4.368642e-03	2.360	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	4.368642e-03	2.360	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	4.368642e-03	2.360	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	4.368642e-03	2.360	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	4.368642e-03	2.360	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	4.368642e-03	2.360	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	4.368642e-03	2.360	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	4.368642e-03	2.360	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	4.368642e-03	2.360	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	4.642400e-03	2.333	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	4.153983e-03	2.382	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	4.153983e-03	2.382	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	4.999020e-03	2.301	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	4.850967e-03	2.314	0	0
UCH proteinases	R-HSA-5689603	4.106150e-03	2.387	0	0
Kinesins	R-HSA-983189	4.188866e-03	2.378	0	0
Signaling by NOTCH1	R-HSA-1980143	4.106150e-03	2.387	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	4.800531e-03	2.319	0	0
p75NTR signals via NF-kB	R-HSA-193639	4.850967e-03	2.314	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.480192e-03	2.349	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	4.714414e-03	2.327	0	0
Pexophagy	R-HSA-9664873	4.398586e-03	2.357	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	4.398586e-03	2.357	0	0
Maturation of protein E	R-HSA-9694493	4.288956e-03	2.368	0	0
Maturation of protein E	R-HSA-9683683	4.288956e-03	2.368	0	0
SARS-CoV-2 Infection	R-HSA-9694516	4.810501e-03	2.318	0	0
G alpha (12/13) signalling events	R-HSA-416482	5.058151e-03	2.296	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	5.127223e-03	2.290	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.127223e-03	2.290	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.127223e-03	2.290	0	0
Signaling by RAS mutants	R-HSA-6802949	5.127223e-03	2.290	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	5.127223e-03	2.290	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	5.127223e-03	2.290	0	0
S Phase	R-HSA-69242	5.246312e-03	2.280	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	5.708577e-03	2.243	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	5.833751e-03	2.234	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	5.833751e-03	2.234	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	5.833751e-03	2.234	0	0
Interleukin-12 family signaling	R-HSA-447115	5.888149e-03	2.230	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	6.432081e-03	2.192	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	6.658744e-03	2.177	0	0
NRAGE signals death through JNK	R-HSA-193648	6.699738e-03	2.174	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	6.834171e-03	2.165	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	6.947964e-03	2.158	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	6.947964e-03	2.158	0	0
HIV Infection	R-HSA-162906	7.037467e-03	2.153	0	0
Signaling by RAF1 mutants	R-HSA-9656223	7.317498e-03	2.136	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.396107e-03	2.131	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	7.742184e-03	2.111	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	7.901079e-03	2.102	0	0
NF-kB is activated and signals survival	R-HSA-209560	7.901079e-03	2.102	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	7.901079e-03	2.102	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.901079e-03	2.102	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	8.271647e-03	2.082	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	8.376445e-03	2.077	0	0
mTORC1-mediated signalling	R-HSA-166208	8.376445e-03	2.077	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.376445e-03	2.077	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	8.960466e-03	2.048	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.130785e-03	2.039	0	0
FLT3 signaling in disease	R-HSA-9682385	9.130785e-03	2.039	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	9.239379e-03	2.034	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	9.239379e-03	2.034	0	0
Regulation of PTEN localization	R-HSA-8948747	9.239379e-03	2.034	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	9.518785e-03	2.021	0	0
Activation of the pre-replicative complex	R-HSA-68962	9.748719e-03	2.011	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.006782e-02	1.997	0	0
Viral Infection Pathways	R-HSA-9824446	1.013334e-02	1.994	0	0
Cellular response to starvation	R-HSA-9711097	1.021740e-02	1.991	0	0
VLDLR internalisation and degradation	R-HSA-8866427	1.022694e-02	1.990	0	0
Orc1 removal from chromatin	R-HSA-68949	1.070320e-02	1.970	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	1.108756e-02	1.955	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.163780e-02	1.934	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.163780e-02	1.934	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.163780e-02	1.934	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.163780e-02	1.934	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.163780e-02	1.934	0	0
Ephrin signaling	R-HSA-3928664	1.170503e-02	1.932	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.170503e-02	1.932	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.186385e-02	1.926	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.238123e-02	1.907	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	1.271055e-02	1.896	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.271055e-02	1.896	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	1.691823e-02	1.772	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.298294e-02	1.887	0	0
Regulation of signaling by CBL	R-HSA-912631	1.414442e-02	1.849	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.691823e-02	1.772	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.506941e-02	1.822	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	1.629441e-02	1.788	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.691823e-02	1.772	0	0
Glycogen synthesis	R-HSA-3322077	1.691712e-02	1.772	0	0
Developmental Cell Lineages	R-HSA-9734767	1.571664e-02	1.804	0	0
Negative regulation of MET activity	R-HSA-6807004	1.691712e-02	1.772	0	0
Autophagy	R-HSA-9612973	1.623549e-02	1.790	0	0
Unwinding of DNA	R-HSA-176974	1.691823e-02	1.772	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	1.629441e-02	1.788	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.271055e-02	1.896	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.620098e-02	1.790	0	0
Death Receptor Signaling	R-HSA-73887	1.440948e-02	1.841	0	0
tRNA processing in the nucleus	R-HSA-6784531	1.283752e-02	1.892	0	0
Modulation by Mtb of host immune system	R-HSA-9637628	1.271055e-02	1.896	0	0
Striated Muscle Contraction	R-HSA-390522	1.723822e-02	1.764	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.817978e-02	1.740	0	0
Host Interactions of HIV factors	R-HSA-162909	1.882715e-02	1.725	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.890013e-02	1.724	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.990977e-02	1.701	0	0
Intracellular signaling by second messengers	R-HSA-9006925	2.063191e-02	1.685	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.178446e-02	1.662	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	2.178446e-02	1.662	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	2.190411e-02	1.659	0	0
Josephin domain DUBs	R-HSA-5689877	2.190411e-02	1.659	0	0
Regulated Necrosis	R-HSA-5218859	2.256396e-02	1.647	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	2.353847e-02	1.628	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	2.353847e-02	1.628	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.421650e-02	1.616	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.421650e-02	1.616	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.421650e-02	1.616	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.421650e-02	1.616	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.421650e-02	1.616	0	0
Breakdown of the nuclear lamina	R-HSA-352238	2.484161e-02	1.605	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.496018e-02	1.603	0	0
EPHB-mediated forward signaling	R-HSA-3928662	2.717891e-02	1.566	0	0
Notch-HLH transcription pathway	R-HSA-350054	2.742117e-02	1.562	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	2.763227e-02	1.559	0	0
Activation of BH3-only proteins	R-HSA-114452	2.843911e-02	1.546	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	2.889637e-02	1.539	0	0
Hedgehog 'on' state	R-HSA-5632684	2.908867e-02	1.536	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	3.223210e-02	1.492	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	3.223210e-02	1.492	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	3.329390e-02	1.478	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	3.421301e-02	1.466	0	0
Glycogen storage diseases	R-HSA-3229121	3.421301e-02	1.466	0	0
Macroautophagy	R-HSA-1632852	3.472061e-02	1.459	0	0
Synthesis of DNA	R-HSA-69239	3.501469e-02	1.456	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	3.571683e-02	1.447	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	3.634889e-02	1.440	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	3.634889e-02	1.440	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.640225e-02	1.439	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	3.668209e-02	1.436	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.687829e-02	1.433	0	0
Signaling by ERBB4	R-HSA-1236394	3.687829e-02	1.433	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	3.712390e-02	1.430	0	0
PIP3 activates AKT signaling	R-HSA-1257604	3.828609e-02	1.417	0	0
rRNA processing	R-HSA-72312	3.850969e-02	1.414	0	0
Hedgehog 'off' state	R-HSA-5610787	3.880677e-02	1.411	0	0
Aggrephagy	R-HSA-9646399	3.899751e-02	1.409	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	4.009780e-02	1.397	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	4.009780e-02	1.397	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	4.009780e-02	1.397	0	0
AURKA Activation by TPX2	R-HSA-8854518	4.044367e-02	1.393	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	4.079809e-02	1.389	0	0
Nuclear RNA decay	R-HSA-9930044	4.079809e-02	1.389	0	0
Activation of ATR in response to replication stress	R-HSA-176187	4.079809e-02	1.389	0	0
Regulation of necroptotic cell death	R-HSA-5675482	4.079809e-02	1.389	0	0
HDMs demethylate histones	R-HSA-3214842	4.152344e-02	1.382	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	4.156948e-02	1.381	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	4.179533e-02	1.379	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.179533e-02	1.379	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	4.179533e-02	1.379	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	4.179533e-02	1.379	0	0
IRAK1 recruits IKK complex	R-HSA-937039	4.179533e-02	1.379	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	4.179533e-02	1.379	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	4.191244e-02	1.378	0	0
Selenoamino acid metabolism	R-HSA-2408522	4.238437e-02	1.373	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	4.259793e-02	1.371	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.656016e-02	1.332	0	0
G2/M Transition	R-HSA-69275	4.755426e-02	1.323	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	4.806423e-02	1.318	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	4.806423e-02	1.318	0	0
Regulation of RAS by GAPs	R-HSA-5658442	4.823833e-02	1.317	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	6.217418e-02	1.206	0	0
MET interacts with TNS proteins	R-HSA-8875513	6.217418e-02	1.206	0	0
Type I hemidesmosome assembly	R-HSA-446107	6.039680e-02	1.219	0	0
Formation of annular gap junctions	R-HSA-196025	6.039680e-02	1.219	0	0
Gap junction degradation	R-HSA-190873	7.404793e-02	1.130	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.926346e-02	1.227	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.306854e-02	1.275	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	6.638114e-02	1.178	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	7.370375e-02	1.133	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	6.522489e-02	1.186	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	6.522489e-02	1.186	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	7.319194e-02	1.136	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.072203e-02	1.295	0	0
IRE1alpha activates chaperones	R-HSA-381070	6.956627e-02	1.158	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	7.370375e-02	1.133	0	0
Nephrin family interactions	R-HSA-373753	5.360551e-02	1.271	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.404793e-02	1.130	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	6.944757e-02	1.158	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	6.039680e-02	1.219	0	0
Translesion synthesis by REV1	R-HSA-110312	6.924286e-02	1.160	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	5.010974e-02	1.300	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	6.705827e-02	1.174	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	5.306854e-02	1.275	0	0
Selective autophagy	R-HSA-9663891	5.439100e-02	1.264	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	5.926346e-02	1.227	0	0
Protein methylation	R-HSA-8876725	6.924286e-02	1.160	0	0
Oncogene Induced Senescence	R-HSA-2559585	5.620778e-02	1.250	0	0
Signaling by FGFR2	R-HSA-5654738	5.665276e-02	1.247	0	0
G1/S Transition	R-HSA-69206	6.548876e-02	1.184	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	5.010974e-02	1.300	0	0
Signaling by FGFR4	R-HSA-5654743	5.731071e-02	1.242	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	5.199724e-02	1.284	0	0
Signaling by FGFR3	R-HSA-5654741	6.821462e-02	1.166	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	5.072203e-02	1.295	0	0
Mitophagy	R-HSA-5205647	5.072203e-02	1.295	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	7.404793e-02	1.130	0	0
Signaling by VEGF	R-HSA-194138	6.548876e-02	1.184	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	6.522489e-02	1.186	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	5.533803e-02	1.257	0	0
Vesicle-mediated transport	R-HSA-5653656	5.707455e-02	1.244	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	6.944757e-02	1.158	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.924286e-02	1.160	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.924286e-02	1.160	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	6.705827e-02	1.174	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	5.230084e-02	1.281	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	6.123539e-02	1.213	0	0
Mitotic G2-G2/M phases	R-HSA-453274	5.190617e-02	1.285	0	0
MAP kinase activation	R-HSA-450294	5.618968e-02	1.250	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.714913e-02	1.243	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	5.876198e-02	1.231	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.411262e-02	1.130	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	7.479885e-02	1.126	0	0
Protein-protein interactions at synapses	R-HSA-6794362	7.776457e-02	1.109	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	7.798306e-02	1.108	0	0
Signaling by FGFR1	R-HSA-5654736	7.798306e-02	1.108	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.798306e-02	1.108	0	0
Translesion synthesis by POLI	R-HSA-5656121	8.002734e-02	1.097	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	8.002734e-02	1.097	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	8.002734e-02	1.097	0	0
Regulation of BACH1 activity	R-HSA-9708530	8.002734e-02	1.097	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.030912e-02	1.095	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	8.030912e-02	1.095	0	0
Budding and maturation of HIV virion	R-HSA-162588	8.146828e-02	1.089	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	8.146828e-02	1.089	0	0
Inositol phosphate metabolism	R-HSA-1483249	8.160619e-02	1.088	0	0
Translation	R-HSA-72766	8.466422e-02	1.072	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	8.503199e-02	1.070	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	8.503199e-02	1.070	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	8.503199e-02	1.070	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	8.503199e-02	1.070	0	0
SARS-CoV Infections	R-HSA-9679506	8.853296e-02	1.053	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	8.893102e-02	1.051	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	8.893102e-02	1.051	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	8.893102e-02	1.051	0	0
Glycogen metabolism	R-HSA-8982491	8.897717e-02	1.051	0	0
Translesion synthesis by POLK	R-HSA-5655862	9.159016e-02	1.038	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.159016e-02	1.038	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.159016e-02	1.038	0	0
Transcription of the HIV genome	R-HSA-167172	9.168930e-02	1.038	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	9.359579e-02	1.029	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	9.359579e-02	1.029	0	0
Nucleotide Excision Repair	R-HSA-5696398	9.600240e-02	1.018	0	0
Deadenylation of mRNA	R-HSA-429947	9.750308e-02	1.011	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.038380e-01	0.984	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.038380e-01	0.984	0	0
Interleukin-17 signaling	R-HSA-448424	1.038380e-01	0.984	0	0
Signaling by MET	R-HSA-6806834	1.038858e-01	0.983	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.038992e-01	0.983	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.038992e-01	0.983	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	1.045645e-01	0.981	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	1.045645e-01	0.981	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.045645e-01	0.981	0	0
Translation of Structural Proteins	R-HSA-9683701	1.045645e-01	0.981	0	0
Signaling by FGFR	R-HSA-190236	1.075700e-01	0.968	0	0
Interleukin-7 signaling	R-HSA-1266695	1.079536e-01	0.967	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.099639e-01	0.959	0	0
IRS activation	R-HSA-74713	1.099639e-01	0.959	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.099639e-01	0.959	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.099639e-01	0.959	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.099639e-01	0.959	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	1.099639e-01	0.959	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	1.157301e-01	0.937	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	1.157301e-01	0.937	0	0
RAF activation	R-HSA-5673000	1.168332e-01	0.932	0	0
Dual Incision in GG-NER	R-HSA-5696400	1.168332e-01	0.932	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	1.168332e-01	0.932	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	1.168332e-01	0.932	0	0
Signaling by NOTCH2	R-HSA-1980145	1.168332e-01	0.932	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.168332e-01	0.932	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	1.168722e-01	0.932	0	0
GAB1 signalosome	R-HSA-180292	1.169176e-01	0.932	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.215231e-01	0.915	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	1.215231e-01	0.915	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	1.220037e-01	0.914	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.236821e-01	0.908	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.236821e-01	0.908	1	1
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.236821e-01	0.908	0	0
Smooth Muscle Contraction	R-HSA-445355	1.236821e-01	0.908	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.237141e-01	0.908	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	1.242299e-01	0.906	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	1.303992e-01	0.885	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.303992e-01	0.885	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.303992e-01	0.885	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	1.304997e-01	0.884	0	0
G1 Phase	R-HSA-69236	1.304997e-01	0.884	0	0
Cyclin D associated events in G1	R-HSA-69231	1.304997e-01	0.884	0	0
Translesion Synthesis by POLH	R-HSA-110320	1.306050e-01	0.884	0	0
Rap1 signalling	R-HSA-392517	1.306050e-01	0.884	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	1.306050e-01	0.884	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.486856e-01	0.828	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.486856e-01	0.828	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.486856e-01	0.828	0	0
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	2.145262e-01	0.669	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.145262e-01	0.669	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.145262e-01	0.669	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.365129e-01	0.865	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	1.365129e-01	0.865	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	1.365129e-01	0.865	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	1.642803e-01	0.784	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	1.642803e-01	0.784	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	1.929193e-01	0.715	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.929193e-01	0.715	0	0
SOS-mediated signalling	R-HSA-112412	1.929193e-01	0.715	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	1.399857e-01	0.854	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.399857e-01	0.854	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.399857e-01	0.854	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.399857e-01	0.854	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.399857e-01	0.854	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.399857e-01	0.854	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.399857e-01	0.854	0	0
Lipophagy	R-HSA-9613354	2.516511e-01	0.599	0	0
ALK mutants bind TKIs	R-HSA-9700645	2.516511e-01	0.599	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	1.984362e-01	0.702	0	0
Phosphorylation of the APC/C	R-HSA-176412	2.190723e-01	0.659	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.190723e-01	0.659	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	1.423515e-01	0.847	0	0
Formation of the Early Elongation Complex	R-HSA-113418	1.423515e-01	0.847	0	0
HIV elongation arrest and recovery	R-HSA-167287	1.423515e-01	0.847	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	1.423515e-01	0.847	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.547581e-01	0.810	0	0
FGFR2 alternative splicing	R-HSA-6803529	1.911360e-01	0.719	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	2.614782e-01	0.583	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.808291e-01	0.743	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.241896e-01	0.649	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.494049e-01	0.826	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	1.816262e-01	0.741	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	1.816262e-01	0.741	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.816262e-01	0.741	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.404167e-01	0.853	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.491865e-01	0.826	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	2.058717e-01	0.686	0	0
HIV Transcription Initiation	R-HSA-167161	2.058717e-01	0.686	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	2.058717e-01	0.686	0	0
Dual incision in TC-NER	R-HSA-6782135	1.674941e-01	0.776	0	0
Centrosome maturation	R-HSA-380287	1.380406e-01	0.860	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	2.311927e-01	0.636	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	1.499482e-01	0.824	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.647799e-01	0.783	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	2.574254e-01	0.589	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	2.574254e-01	0.589	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.674751e-01	0.776	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	2.298197e-01	0.639	0	0
HIV Transcription Elongation	R-HSA-167169	1.816262e-01	0.741	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.816262e-01	0.741	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.007224e-01	0.697	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.816262e-01	0.741	0	0
Degradation of DVL	R-HSA-4641258	1.476114e-01	0.831	0	0
DNA Damage Bypass	R-HSA-73893	1.799862e-01	0.745	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	1.822377e-01	0.739	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.699558e-01	0.770	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.699558e-01	0.770	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	2.129438e-01	0.672	0	0
Recycling pathway of L1	R-HSA-437239	1.593135e-01	0.798	0	0
Myogenesis	R-HSA-525793	2.585693e-01	0.587	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	1.547581e-01	0.810	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	2.574254e-01	0.589	0	0
Regulation of mitotic cell cycle	R-HSA-453276	1.913832e-01	0.718	1	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	1.913832e-01	0.718	1	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.365129e-01	0.865	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	1.476114e-01	0.831	0	0
Signaling by NOTCH3	R-HSA-9012852	1.404167e-01	0.853	0	0
Pyroptosis	R-HSA-5620971	1.423515e-01	0.847	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.365129e-01	0.865	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	1.783079e-01	0.749	0	0
Calcineurin activates NFAT	R-HSA-2025928	2.516511e-01	0.599	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.675931e-01	0.776	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.614782e-01	0.583	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	1.936046e-01	0.713	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	1.936046e-01	0.713	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	2.520028e-01	0.599	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	2.520028e-01	0.599	0	0
Fanconi Anemia Pathway	R-HSA-6783310	2.574254e-01	0.589	0	0
Signaling by NOTCH4	R-HSA-9013694	1.307718e-01	0.883	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.464531e-01	0.834	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.401176e-01	0.620	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	1.587894e-01	0.799	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	2.606988e-01	0.584	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.780598e-01	0.749	0	0
Frs2-mediated activation	R-HSA-170968	1.587894e-01	0.799	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.585693e-01	0.587	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.365129e-01	0.865	0	0
DNA strand elongation	R-HSA-69190	1.944377e-01	0.711	0	0
Degradation of CDH1	R-HSA-9766229	1.799862e-01	0.745	0	0
Signaling by Hedgehog	R-HSA-5358351	1.909403e-01	0.719	0	0
Ovarian tumor domain proteases	R-HSA-5689896	1.476114e-01	0.831	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	1.699558e-01	0.770	0	0
DAG and IP3 signaling	R-HSA-1489509	2.574254e-01	0.589	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	2.574254e-01	0.589	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	2.516511e-01	0.599	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.397969e-01	0.855	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.397969e-01	0.855	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	2.058717e-01	0.686	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.936046e-01	0.713	0	0
Prolonged ERK activation events	R-HSA-169893	2.190723e-01	0.659	0	0
Interleukin-1 signaling	R-HSA-9020702	1.976736e-01	0.704	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	2.083896e-01	0.681	0	0
Formation of the cornified envelope	R-HSA-6809371	2.278937e-01	0.642	0	0
RAF/MAP kinase cascade	R-HSA-5673001	2.264832e-01	0.645	0	0
Inhibition of PKR	R-HSA-169131	1.486856e-01	0.828	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.145262e-01	0.669	0	0
Manipulation of host energy metabolism	R-HSA-9636667	2.145262e-01	0.669	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.145262e-01	0.669	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	2.221293e-01	0.653	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.984362e-01	0.702	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	1.984362e-01	0.702	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	1.984362e-01	0.702	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.547581e-01	0.810	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.401176e-01	0.620	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	1.816262e-01	0.741	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.603070e-01	0.795	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	1.816262e-01	0.741	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	2.083896e-01	0.681	0	0
Cellular response to hypoxia	R-HSA-1234174	2.386767e-01	0.622	0	0
DCC mediated attractive signaling	R-HSA-418885	1.984362e-01	0.702	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.967463e-01	0.706	0	0
Neurodegenerative Diseases	R-HSA-8863678	2.241896e-01	0.649	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.241896e-01	0.649	0	0
CHL1 interactions	R-HSA-447041	1.929193e-01	0.715	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	2.516511e-01	0.599	0	0
Interleukin-1 processing	R-HSA-448706	2.516511e-01	0.599	0	0
Protein hydroxylation	R-HSA-9629569	1.449176e-01	0.839	0	0
Vpu mediated degradation of CD4	R-HSA-180534	2.226547e-01	0.652	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	2.372026e-01	0.625	0	0
Regulation of Apoptosis	R-HSA-169911	2.520028e-01	0.599	0	0
TNF signaling	R-HSA-75893	2.599343e-01	0.585	0	0
Muscle contraction	R-HSA-397014	2.479839e-01	0.606	0	0
Interleukin-1 family signaling	R-HSA-446652	2.161875e-01	0.665	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	1.482258e-01	0.829	0	0
MHC class II antigen presentation	R-HSA-2132295	1.469237e-01	0.833	0	0
L1CAM interactions	R-HSA-373760	1.706989e-01	0.768	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.908291e-01	0.719	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	1.908291e-01	0.719	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.558090e-01	0.807	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.397969e-01	0.855	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.695112e-01	0.771	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.365129e-01	0.865	0	0
Maturation of nucleoprotein	R-HSA-9683610	1.587894e-01	0.799	0	0
ARMS-mediated activation	R-HSA-170984	2.516511e-01	0.599	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.190723e-01	0.659	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.401176e-01	0.620	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.476114e-01	0.831	0	0
Stabilization of p53	R-HSA-69541	1.699558e-01	0.770	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.674751e-01	0.776	0	0
Calnexin/calreticulin cycle	R-HSA-901042	2.372026e-01	0.625	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.747996e-01	0.757	0	0
Cardiogenesis	R-HSA-9733709	2.083896e-01	0.681	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.747996e-01	0.757	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.747996e-01	0.757	0	0
Signaling by FGFR in disease	R-HSA-1226099	2.199491e-01	0.658	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.911360e-01	0.719	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.083896e-01	0.681	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.318298e-01	0.880	0	0
Semaphorin interactions	R-HSA-373755	2.173288e-01	0.663	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.371835e-01	0.625	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.516511e-01	0.599	0	0
Assembly Of The HIV Virion	R-HSA-175474	1.752317e-01	0.756	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	1.576555e-01	0.802	0	0
Plasma lipoprotein clearance	R-HSA-8964043	1.699558e-01	0.770	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.911360e-01	0.719	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.365129e-01	0.865	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	2.516511e-01	0.599	0	0
MITF-M-dependent gene expression	R-HSA-9856651	2.030860e-01	0.692	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	1.598091e-01	0.796	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	1.494049e-01	0.826	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.380406e-01	0.860	0	0
Signaling by Interleukins	R-HSA-449147	1.774563e-01	0.751	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	1.598091e-01	0.796	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	1.547581e-01	0.810	0	0
Suppression of phagosomal maturation	R-HSA-9637687	2.585693e-01	0.587	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.752317e-01	0.756	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.491865e-01	0.826	0	0
Rab regulation of trafficking	R-HSA-9007101	2.618825e-01	0.582	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	2.629116e-01	0.580	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	2.644978e-01	0.578	0	0
Calmodulin induced events	R-HSA-111933	2.670246e-01	0.573	0	0
CaM pathway	R-HSA-111997	2.670246e-01	0.573	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	2.670246e-01	0.573	0	0
RUNX2 regulates bone development	R-HSA-8941326	2.670246e-01	0.573	0	0
RET signaling	R-HSA-8853659	2.670246e-01	0.573	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.671837e-01	0.573	0	0
Signaling by NTRKs	R-HSA-166520	2.682869e-01	0.571	0	0
ER-Phagosome pathway	R-HSA-1236974	2.690693e-01	0.570	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.719331e-01	0.566	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.733566e-01	0.563	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	2.752783e-01	0.560	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	2.752783e-01	0.560	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	2.752783e-01	0.560	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	2.752783e-01	0.560	0	0
Defective DHDDS causes RP59	R-HSA-4755609	2.752783e-01	0.560	0	0
Interleukin-33 signaling	R-HSA-9014843	2.752783e-01	0.560	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	2.761333e-01	0.559	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.761333e-01	0.559	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	2.761333e-01	0.559	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	2.788287e-01	0.555	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	2.788287e-01	0.555	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	2.788287e-01	0.555	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.789829e-01	0.554	0	0
PTEN Regulation	R-HSA-6807070	2.796583e-01	0.553	0	0
Regulation of CDH11 function	R-HSA-9762292	2.812619e-01	0.551	0	0
PI3K/AKT activation	R-HSA-198203	2.812619e-01	0.551	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	2.812619e-01	0.551	0	0
Signal attenuation	R-HSA-74749	2.812619e-01	0.551	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	2.812619e-01	0.551	0	0
Signaling by Leptin	R-HSA-2586552	2.812619e-01	0.551	0	0
Degradation of AXIN	R-HSA-4641257	2.822376e-01	0.549	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	2.830649e-01	0.548	0	0
MAPK family signaling cascades	R-HSA-5683057	2.836241e-01	0.547	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.938832e-01	0.532	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	2.947875e-01	0.530	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	2.969322e-01	0.527	0	0
MET promotes cell motility	R-HSA-8875878	2.976115e-01	0.526	0	0
Gluconeogenesis	R-HSA-70263	2.981163e-01	0.526	0	0
NGF-stimulated transcription	R-HSA-9031628	2.981163e-01	0.526	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	2.988936e-01	0.524	0	0
Specification of the neural plate border	R-HSA-9834899	3.047939e-01	0.516	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	3.047939e-01	0.516	0	0
Maturation of nucleoprotein	R-HSA-9694631	3.047939e-01	0.516	0	0
STING mediated induction of host immune responses	R-HSA-1834941	3.047939e-01	0.516	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	3.048701e-01	0.516	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	3.048701e-01	0.516	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	3.096749e-01	0.509	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	3.104471e-01	0.508	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	3.107715e-01	0.508	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	3.107715e-01	0.508	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	3.107715e-01	0.508	0	0
Formation of the posterior neural plate	R-HSA-9832991	3.107715e-01	0.508	0	0
Bicarbonate transporters	R-HSA-425381	3.107715e-01	0.508	0	0
Signaling by APC mutants	R-HSA-4839744	3.107715e-01	0.508	0	0
Suppression of apoptosis	R-HSA-9635465	3.107715e-01	0.508	0	0
Regulation of gene expression in beta cells	R-HSA-210745	3.117728e-01	0.506	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	3.119533e-01	0.506	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	3.131166e-01	0.504	0	0
PLC beta mediated events	R-HSA-112043	3.221983e-01	0.492	0	0
Formation of definitive endoderm	R-HSA-9823730	3.265869e-01	0.486	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.297577e-01	0.482	0	0
Interleukin-37 signaling	R-HSA-9008059	3.297577e-01	0.482	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	3.313349e-01	0.480	0	0
MET activates PTPN11	R-HSA-8865999	3.313349e-01	0.480	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.313349e-01	0.480	0	0
CASP5-mediated substrate cleavage	R-HSA-9960525	3.313349e-01	0.480	0	0
Histamine receptors	R-HSA-390650	3.313349e-01	0.480	0	0
CASP4-mediated substrate cleavage	R-HSA-9960519	3.313349e-01	0.480	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	3.349646e-01	0.475	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	3.357434e-01	0.474	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	3.399119e-01	0.469	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	3.399119e-01	0.469	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.400186e-01	0.468	0	0
Signaling by AXIN mutants	R-HSA-4839735	3.400186e-01	0.468	0	0
Signaling by AMER1 mutants	R-HSA-4839748	3.400186e-01	0.468	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	3.400186e-01	0.468	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.400186e-01	0.468	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	3.444046e-01	0.463	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.444046e-01	0.463	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	3.444046e-01	0.463	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	3.444046e-01	0.463	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	3.468427e-01	0.460	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.483712e-01	0.458	0	0
Basigin interactions	R-HSA-210991	3.483712e-01	0.458	0	0
Neurexins and neuroligins	R-HSA-6794361	3.539930e-01	0.451	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	3.579945e-01	0.446	0	0
Platelet degranulation	R-HSA-114608	3.586812e-01	0.445	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	3.601314e-01	0.444	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	3.603577e-01	0.443	0	0
Signaling by TGFB family members	R-HSA-9006936	3.628211e-01	0.440	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	3.681153e-01	0.434	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	3.688674e-01	0.433	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	3.688674e-01	0.433	0	0
Scavenging by Class F Receptors	R-HSA-3000484	3.688674e-01	0.433	0	0
Repression of WNT target genes	R-HSA-4641265	3.688674e-01	0.433	0	0
Disorders of Nervous System Development	R-HSA-9697154	3.688674e-01	0.433	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	3.688674e-01	0.433	0	0
Pervasive developmental disorders	R-HSA-9005895	3.688674e-01	0.433	0	0
Post NMDA receptor activation events	R-HSA-438064	3.691889e-01	0.433	0	0
Antigen processing-Cross presentation	R-HSA-1236975	3.740759e-01	0.427	0	0
Ca-dependent events	R-HSA-111996	3.758775e-01	0.425	0	0
Translation of Structural Proteins	R-HSA-9694635	3.775404e-01	0.423	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	3.779399e-01	0.423	0	0
HCN channels	R-HSA-1296061	3.830587e-01	0.417	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	3.830587e-01	0.417	0	0
Regulation of gap junction activity	R-HSA-191650	3.830587e-01	0.417	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	3.830587e-01	0.417	0	0
Dopamine receptors	R-HSA-390651	3.830587e-01	0.417	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	3.830587e-01	0.417	0	0
NADE modulates death signalling	R-HSA-205025	3.830587e-01	0.417	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	3.838688e-01	0.416	1	1
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.838688e-01	0.416	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	3.861658e-01	0.413	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.871781e-01	0.412	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	3.895510e-01	0.409	0	0
PCP/CE pathway	R-HSA-4086400	3.895510e-01	0.409	0	0
TBC/RABGAPs	R-HSA-8854214	3.916169e-01	0.407	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	3.916169e-01	0.407	0	0
FOXO-mediated transcription	R-HSA-9614085	3.931657e-01	0.405	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	3.972047e-01	0.401	0	0
Formation of axial mesoderm	R-HSA-9796292	3.972047e-01	0.401	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	3.972047e-01	0.401	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	3.972047e-01	0.401	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	3.972047e-01	0.401	0	0
G-protein mediated events	R-HSA-112040	3.995156e-01	0.398	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.018293e-01	0.396	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	4.045598e-01	0.393	0	0
Netrin-1 signaling	R-HSA-373752	4.073251e-01	0.390	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	4.130297e-01	0.384	0	0
Syndecan interactions	R-HSA-3000170	4.130297e-01	0.384	0	0
Circadian clock	R-HSA-9909396	4.138461e-01	0.383	0	0
Interferon Signaling	R-HSA-913531	4.198705e-01	0.377	0	0
Adaptive Immune System	R-HSA-1280218	4.218569e-01	0.375	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	4.230921e-01	0.374	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	4.238520e-01	0.373	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	4.249371e-01	0.372	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	4.249371e-01	0.372	0	0
Physiological factors	R-HSA-5578768	4.249371e-01	0.372	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.250780e-01	0.372	0	0
Activation of AMPA receptors	R-HSA-399710	4.307843e-01	0.366	0	0
G2 Phase	R-HSA-68911	4.307843e-01	0.366	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.307843e-01	0.366	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	4.307843e-01	0.366	0	0
Defective F9 activation	R-HSA-9673221	4.307843e-01	0.366	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	4.307843e-01	0.366	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	4.307843e-01	0.366	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	4.307843e-01	0.366	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	4.307843e-01	0.366	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	4.307843e-01	0.366	0	0
Interleukin-36 pathway	R-HSA-9014826	4.307843e-01	0.366	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.307843e-01	0.366	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	4.341645e-01	0.362	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	4.367136e-01	0.360	0	0
Signalling to ERKs	R-HSA-187687	4.374268e-01	0.359	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	4.385542e-01	0.358	0	0
Signaling by TGFBR3	R-HSA-9839373	4.385542e-01	0.358	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	4.463243e-01	0.350	0	0
Erythropoietin activates RAS	R-HSA-9027284	4.519886e-01	0.345	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	4.519886e-01	0.345	0	0
Formation of the anterior neural plate	R-HSA-9823739	4.519886e-01	0.345	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	4.519886e-01	0.345	0	0
Sema4D in semaphorin signaling	R-HSA-400685	4.550104e-01	0.342	0	0
TGFBR3 expression	R-HSA-9839394	4.550104e-01	0.342	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	4.591381e-01	0.338	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	4.600372e-01	0.337	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	4.639500e-01	0.334	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	4.639500e-01	0.334	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.666721e-01	0.331	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	4.748205e-01	0.323	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	4.748205e-01	0.323	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	4.748205e-01	0.323	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	4.748205e-01	0.323	0	0
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	4.748205e-01	0.323	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	4.748205e-01	0.323	0	0
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	4.748205e-01	0.323	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	4.748205e-01	0.323	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	4.748205e-01	0.323	0	0
Release of apoptotic factors from the mitochondria	R-HSA-111457	4.748205e-01	0.323	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	4.755271e-01	0.323	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	4.782987e-01	0.320	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	4.782987e-01	0.320	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	4.782987e-01	0.320	0	0
Activation of SMO	R-HSA-5635838	4.782987e-01	0.320	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	4.851462e-01	0.314	0	0
Heme signaling	R-HSA-9707616	4.940868e-01	0.306	0	0
Cristae formation	R-HSA-8949613	4.956789e-01	0.305	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	4.956789e-01	0.305	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	5.038203e-01	0.298	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.038203e-01	0.298	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.038203e-01	0.298	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	5.038203e-01	0.298	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.038203e-01	0.298	0	0
Disorders of Developmental Biology	R-HSA-9675151	5.038203e-01	0.298	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	5.038203e-01	0.298	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	5.065086e-01	0.295	0	0
RAS processing	R-HSA-9648002	5.065086e-01	0.295	0	0
Pyruvate metabolism	R-HSA-70268	5.085346e-01	0.294	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	5.145668e-01	0.289	0	0
Signaling by LTK in cancer	R-HSA-9842640	5.154524e-01	0.288	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.154524e-01	0.288	0	0
Erythropoietin activates STAT5	R-HSA-9027283	5.154524e-01	0.288	0	0
STAT5 Activation	R-HSA-9645135	5.154524e-01	0.288	0	0
Autointegration results in viral DNA circles	R-HSA-177539	5.154524e-01	0.288	0	0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	5.154524e-01	0.288	0	0
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	5.154524e-01	0.288	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	5.154524e-01	0.288	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	5.154524e-01	0.288	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	5.154524e-01	0.288	0	0
Abacavir transmembrane transport	R-HSA-2161517	5.154524e-01	0.288	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	5.154524e-01	0.288	0	0
Nef and signal transduction	R-HSA-164944	5.154524e-01	0.288	0	0
Neurofascin interactions	R-HSA-447043	5.154524e-01	0.288	0	0
TCR signaling	R-HSA-202403	5.196002e-01	0.284	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	5.285178e-01	0.277	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	5.285178e-01	0.277	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	5.285178e-01	0.277	0	0
Specification of primordial germ cells	R-HSA-9827857	5.285178e-01	0.277	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	5.285178e-01	0.277	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	5.292719e-01	0.276	0	0
Signaling by Erythropoietin	R-HSA-9006335	5.347680e-01	0.272	0	0
mRNA Capping	R-HSA-72086	5.347680e-01	0.272	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.396038e-01	0.268	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	5.437755e-01	0.265	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	5.466526e-01	0.262	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	5.523661e-01	0.258	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	5.523661e-01	0.258	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	5.523661e-01	0.258	0	0
Mismatch Repair	R-HSA-5358508	5.523661e-01	0.258	0	0
Nephron development	R-HSA-9831926	5.523661e-01	0.258	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	5.523661e-01	0.258	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	5.523661e-01	0.258	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	5.529429e-01	0.257	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	5.529429e-01	0.257	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	5.529429e-01	0.257	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	5.529429e-01	0.257	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	5.529429e-01	0.257	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	5.529429e-01	0.257	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	5.529429e-01	0.257	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.529429e-01	0.257	0	0
VLDL clearance	R-HSA-8964046	5.529429e-01	0.257	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	5.529429e-01	0.257	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	5.529429e-01	0.257	0	0
Neutrophil degranulation	R-HSA-6798695	5.531469e-01	0.257	0	0
tRNA processing	R-HSA-72306	5.565290e-01	0.255	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	5.600998e-01	0.252	0	0
PKR-mediated signaling	R-HSA-9833482	5.629308e-01	0.250	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	5.629308e-01	0.250	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	5.715322e-01	0.243	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.715322e-01	0.243	0	0
Molecules associated with elastic fibres	R-HSA-2129379	5.720785e-01	0.243	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	5.753487e-01	0.240	0	0
Germ layer formation at gastrulation	R-HSA-9754189	5.753487e-01	0.240	0	0
The NLRP3 inflammasome	R-HSA-844456	5.753487e-01	0.240	0	0
Opioid Signalling	R-HSA-111885	5.780670e-01	0.238	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	5.828604e-01	0.234	0	0
Signaling by SCF-KIT	R-HSA-1433557	5.870223e-01	0.231	0	0
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	5.875348e-01	0.231	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	5.875348e-01	0.231	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	5.875348e-01	0.231	0	0
MET receptor recycling	R-HSA-8875656	5.875348e-01	0.231	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	5.875348e-01	0.231	0	0
FGFR1b ligand binding and activation	R-HSA-190370	5.875348e-01	0.231	0	0
TGFBR3 PTM regulation	R-HSA-9839383	5.875348e-01	0.231	0	0
Adrenoceptors	R-HSA-390696	5.875348e-01	0.231	0	0
Sodium/Proton exchangers	R-HSA-425986	5.875348e-01	0.231	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	5.875348e-01	0.231	0	0
RSV-host interactions	R-HSA-9833110	5.883201e-01	0.230	0	0
Signaling by WNT in cancer	R-HSA-4791275	5.900211e-01	0.229	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	5.900211e-01	0.229	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	5.922130e-01	0.228	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	5.974567e-01	0.224	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	5.974567e-01	0.224	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	5.974567e-01	0.224	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	5.974567e-01	0.224	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	5.974567e-01	0.224	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	5.974567e-01	0.224	0	0
Signaling by NODAL	R-HSA-1181150	5.974567e-01	0.224	0	0
Signal transduction by L1	R-HSA-445144	5.974567e-01	0.224	0	0
Creatine metabolism	R-HSA-71288	5.974567e-01	0.224	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	5.978779e-01	0.223	0	0
Amine ligand-binding receptors	R-HSA-375280	6.021805e-01	0.220	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	6.074710e-01	0.216	0	0
G-protein beta:gamma signalling	R-HSA-397795	6.074710e-01	0.216	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	6.074710e-01	0.216	0	0
Infectious disease	R-HSA-5663205	6.122485e-01	0.213	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	6.186881e-01	0.209	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	6.186881e-01	0.209	0	0
WNT mediated activation of DVL	R-HSA-201688	6.194519e-01	0.208	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.194519e-01	0.208	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	6.194519e-01	0.208	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.194519e-01	0.208	0	0
Regulation of signaling by NODAL	R-HSA-1433617	6.194519e-01	0.208	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	6.194519e-01	0.208	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	6.194519e-01	0.208	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	6.194519e-01	0.208	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	6.194519e-01	0.208	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	6.194519e-01	0.208	0	0
Toll-like Receptor Cascades	R-HSA-168898	6.206868e-01	0.207	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	6.244188e-01	0.205	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.244188e-01	0.205	0	0
Peroxisomal protein import	R-HSA-9033241	6.259193e-01	0.203	0	0
Regulation of beta-cell development	R-HSA-186712	6.259193e-01	0.203	0	0
SLC transporter disorders	R-HSA-5619102	6.271667e-01	0.203	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	6.390459e-01	0.194	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	6.390459e-01	0.194	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	6.390459e-01	0.194	0	0
Ribavirin ADME	R-HSA-9755088	6.390459e-01	0.194	0	0
Signaling by PDGFR in disease	R-HSA-9671555	6.390459e-01	0.194	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	6.408577e-01	0.193	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	6.489011e-01	0.188	0	0
Folding of actin by CCT/TriC	R-HSA-390450	6.489011e-01	0.188	0	0
Binding and entry of HIV virion	R-HSA-173107	6.489011e-01	0.188	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	6.489011e-01	0.188	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	6.489011e-01	0.188	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	6.489011e-01	0.188	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	6.489011e-01	0.188	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	6.489011e-01	0.188	0	0
2-LTR circle formation	R-HSA-164843	6.489011e-01	0.188	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	6.489011e-01	0.188	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	6.512312e-01	0.186	0	0
Disorders of transmembrane transporters	R-HSA-5619115	6.567366e-01	0.183	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	6.567834e-01	0.183	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	6.567834e-01	0.183	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	6.585383e-01	0.181	0	0
LDL clearance	R-HSA-8964038	6.585383e-01	0.181	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.585383e-01	0.181	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	6.585383e-01	0.181	0	0
Co-stimulation by CD28	R-HSA-389356	6.593233e-01	0.181	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	6.653495e-01	0.177	0	0
ABC-family proteins mediated transport	R-HSA-382556	6.690514e-01	0.175	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	6.721940e-01	0.173	0	0
RNA Polymerase III Transcription	R-HSA-74158	6.721940e-01	0.173	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	6.721940e-01	0.173	0	0
G1/S-Specific Transcription	R-HSA-69205	6.721940e-01	0.173	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	6.721940e-01	0.173	0	0
Gap junction trafficking and regulation	R-HSA-157858	6.727067e-01	0.172	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	6.760729e-01	0.170	0	0
LGI-ADAM interactions	R-HSA-5682910	6.760729e-01	0.170	0	0
vRNP Assembly	R-HSA-192905	6.760729e-01	0.170	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	6.760729e-01	0.170	0	0
Transport of RCbl within the body	R-HSA-9758890	6.760729e-01	0.170	0	0
Dissolution of Fibrin Clot	R-HSA-75205	6.760729e-01	0.170	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	6.771772e-01	0.169	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	6.771772e-01	0.169	0	0
Growth hormone receptor signaling	R-HSA-982772	6.771772e-01	0.169	0	0
PI3K Cascade	R-HSA-109704	6.857222e-01	0.164	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	6.857222e-01	0.164	0	0
IGF1R signaling cascade	R-HSA-2428924	6.870990e-01	0.163	0	0
ABC transporter disorders	R-HSA-5619084	6.898182e-01	0.161	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.984824e-01	0.156	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.011433e-01	0.154	0	0
Integration of provirus	R-HSA-162592	7.011433e-01	0.154	0	0
ERKs are inactivated	R-HSA-202670	7.011433e-01	0.154	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.011433e-01	0.154	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.011433e-01	0.154	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.011433e-01	0.154	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.011433e-01	0.154	0	0
Proton-coupled monocarboxylate transport	R-HSA-433692	7.011433e-01	0.154	0	0
Activation of RAC1	R-HSA-428540	7.011433e-01	0.154	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	7.014721e-01	0.154	0	0
Elastic fibre formation	R-HSA-1566948	7.014721e-01	0.154	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	7.119587e-01	0.148	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	7.119587e-01	0.148	0	0
Laminin interactions	R-HSA-3000157	7.119587e-01	0.148	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.119587e-01	0.148	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.119587e-01	0.148	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	7.242748e-01	0.140	0	0
Maple Syrup Urine Disease	R-HSA-9865114	7.242748e-01	0.140	0	0
GRB2 events in EGFR signaling	R-HSA-179812	7.242748e-01	0.140	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.242748e-01	0.140	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.242748e-01	0.140	0	0
Signaling by LTK	R-HSA-9842663	7.242748e-01	0.140	0	0
Polymerase switching	R-HSA-69091	7.242748e-01	0.140	0	0
Leading Strand Synthesis	R-HSA-69109	7.242748e-01	0.140	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	7.242748e-01	0.140	0	0
Interleukin-15 signaling	R-HSA-8983432	7.242748e-01	0.140	0	0
OAS antiviral response	R-HSA-8983711	7.242748e-01	0.140	0	0
Mitochondrial biogenesis	R-HSA-1592230	7.259539e-01	0.139	0	0
Abacavir ADME	R-HSA-2161522	7.281397e-01	0.138	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	7.287136e-01	0.137	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	7.287136e-01	0.137	0	0
Generation of second messenger molecules	R-HSA-202433	7.287136e-01	0.137	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.287136e-01	0.137	0	0
Diseases of Immune System	R-HSA-5260271	7.287136e-01	0.137	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	7.308947e-01	0.136	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	7.435429e-01	0.129	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	7.435429e-01	0.129	0	0
Processing of SMDT1	R-HSA-8949664	7.456172e-01	0.127	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	7.456172e-01	0.127	0	0
FGFR1c ligand binding and activation	R-HSA-190373	7.456172e-01	0.127	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	7.456172e-01	0.127	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	7.456172e-01	0.127	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	7.456172e-01	0.127	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	7.456172e-01	0.127	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	7.456172e-01	0.127	0	0
Interleukin-6 signaling	R-HSA-1059683	7.456172e-01	0.127	0	0
Ion homeostasis	R-HSA-5578775	7.560782e-01	0.121	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.560782e-01	0.121	0	0
Telomere Extension By Telomerase	R-HSA-171319	7.581918e-01	0.120	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	7.581918e-01	0.120	0	0
Inflammasomes	R-HSA-622312	7.581918e-01	0.120	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	7.581918e-01	0.120	0	0
Removal of the Flap Intermediate	R-HSA-69166	7.653087e-01	0.116	0	0
Retrograde neurotrophin signalling	R-HSA-177504	7.653087e-01	0.116	0	0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	7.653087e-01	0.116	0	0
cGMP effects	R-HSA-418457	7.653087e-01	0.116	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	7.653087e-01	0.116	0	0
CRMPs in Sema3A signaling	R-HSA-399956	7.653087e-01	0.116	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	7.653087e-01	0.116	0	0
Regulation of KIT signaling	R-HSA-1433559	7.653087e-01	0.116	0	0
Non-canonical inflammasome activation	R-HSA-9686114	7.653087e-01	0.116	0	0
P2Y receptors	R-HSA-417957	7.653087e-01	0.116	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	7.658615e-01	0.116	0	0
IRS-mediated signalling	R-HSA-112399	7.665327e-01	0.115	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	7.721109e-01	0.112	0	0
Platelet calcium homeostasis	R-HSA-418360	7.721109e-01	0.112	0	0
DARPP-32 events	R-HSA-180024	7.721109e-01	0.112	0	0
Glucagon-type ligand receptors	R-HSA-420092	7.721109e-01	0.112	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	7.721109e-01	0.112	0	0
Cellular response to chemical stress	R-HSA-9711123	7.756648e-01	0.110	0	0
Ca2+ pathway	R-HSA-4086398	7.791536e-01	0.108	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	7.791536e-01	0.108	0	0
Chaperonin-mediated protein folding	R-HSA-390466	7.832078e-01	0.106	0	0
SHC1 events in EGFR signaling	R-HSA-180336	7.834771e-01	0.106	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	7.834771e-01	0.106	0	0
Processive synthesis on the lagging strand	R-HSA-69183	7.834771e-01	0.106	0	0
Protein lipoylation	R-HSA-9857492	7.834771e-01	0.106	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	7.834771e-01	0.106	0	0
p38MAPK events	R-HSA-171007	7.834771e-01	0.106	0	0
Transport and metabolism of PAPS	R-HSA-174362	7.834771e-01	0.106	0	0
DNA Damage Reversal	R-HSA-73942	7.834771e-01	0.106	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	7.834771e-01	0.106	0	0
Other semaphorin interactions	R-HSA-416700	7.834771e-01	0.106	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	7.848930e-01	0.105	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.853252e-01	0.105	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	7.853252e-01	0.105	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	7.853252e-01	0.105	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.853252e-01	0.105	0	0
Gastrulation	R-HSA-9758941	7.856000e-01	0.105	0	0
Gap junction trafficking	R-HSA-190828	7.882490e-01	0.103	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	7.957958e-01	0.099	0	0
Iron uptake and transport	R-HSA-917937	7.964865e-01	0.099	0	0
Downstream signal transduction	R-HSA-186763	7.978606e-01	0.098	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.987596e-01	0.098	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.987596e-01	0.098	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	7.996535e-01	0.097	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	8.002399e-01	0.097	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.002399e-01	0.097	0	0
Killing mechanisms	R-HSA-9664420	8.002399e-01	0.097	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	8.002399e-01	0.097	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	8.002399e-01	0.097	0	0
Attachment and Entry	R-HSA-9678110	8.002399e-01	0.097	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	8.002399e-01	0.097	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.002399e-01	0.097	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.002399e-01	0.097	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	8.002399e-01	0.097	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	8.002399e-01	0.097	0	0
Differentiation of T cells	R-HSA-9945266	8.002399e-01	0.097	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.002399e-01	0.097	0	0
Atorvastatin ADME	R-HSA-9754706	8.002399e-01	0.097	0	0
Downstream TCR signaling	R-HSA-202424	8.066359e-01	0.093	0	0
Diseases of DNA repair	R-HSA-9675135	8.088297e-01	0.092	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.088297e-01	0.092	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.088297e-01	0.092	0	0
G0 and Early G1	R-HSA-1538133	8.097428e-01	0.092	0	0
Mitochondrial protein import	R-HSA-1268020	8.136110e-01	0.090	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.136110e-01	0.090	0	0
Glycine degradation	R-HSA-6783984	8.157060e-01	0.088	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	8.157060e-01	0.088	0	0
Fibronectin matrix formation	R-HSA-1566977	8.157060e-01	0.088	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	8.157060e-01	0.088	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	8.157060e-01	0.088	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	8.157060e-01	0.088	0	0
Passive transport by Aquaporins	R-HSA-432047	8.157060e-01	0.088	0	0
Galactose catabolism	R-HSA-70370	8.157060e-01	0.088	0	0
Coenzyme A biosynthesis	R-HSA-196783	8.157060e-01	0.088	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	8.157060e-01	0.088	0	0
Integrin signaling	R-HSA-354192	8.209978e-01	0.086	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	8.209978e-01	0.086	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	8.209978e-01	0.086	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	8.209978e-01	0.086	0	0
GPER1 signaling	R-HSA-9634597	8.276952e-01	0.082	0	0
Sensory processing of sound	R-HSA-9659379	8.279246e-01	0.082	0	0
Protein folding	R-HSA-391251	8.280423e-01	0.082	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.280423e-01	0.082	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.299754e-01	0.081	0	0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	8.299754e-01	0.081	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.299754e-01	0.081	0	0
Insulin receptor signalling cascade	R-HSA-74751	8.301320e-01	0.081	0	0
Disease	R-HSA-1643685	8.312989e-01	0.080	0	0
Resolution of D-Loop Structures	R-HSA-5693537	8.316515e-01	0.080	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	8.316515e-01	0.080	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	8.316515e-01	0.080	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.375611e-01	0.077	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.417295e-01	0.075	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.417295e-01	0.075	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.417295e-01	0.075	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.421005e-01	0.075	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	8.431408e-01	0.074	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.431408e-01	0.074	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	8.431408e-01	0.074	0	0
PKA activation	R-HSA-163615	8.431408e-01	0.074	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	8.431408e-01	0.074	0	0
PKA activation in glucagon signalling	R-HSA-164378	8.431408e-01	0.074	0	0
FGFR1 ligand binding and activation	R-HSA-190242	8.431408e-01	0.074	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	8.431408e-01	0.074	0	0
Platelet sensitization by LDL	R-HSA-432142	8.431408e-01	0.074	0	0
Tie2 Signaling	R-HSA-210993	8.431408e-01	0.074	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	8.431408e-01	0.074	0	0
Apoptotic factor-mediated response	R-HSA-111471	8.431408e-01	0.074	0	0
Stimuli-sensing channels	R-HSA-2672351	8.477494e-01	0.072	0	0
Kidney development	R-HSA-9830369	8.526127e-01	0.069	0	0
Immune System	R-HSA-168256	8.529054e-01	0.069	0	0
Hemostasis	R-HSA-109582	8.552803e-01	0.068	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	8.552875e-01	0.068	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.552875e-01	0.068	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.552875e-01	0.068	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	8.552875e-01	0.068	0	0
Diseases of hemostasis	R-HSA-9671793	8.552875e-01	0.068	0	0
Cilium Assembly	R-HSA-5617833	8.573750e-01	0.067	0	0
GPVI-mediated activation cascade	R-HSA-114604	8.602590e-01	0.065	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.602590e-01	0.065	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	8.664943e-01	0.062	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	8.664943e-01	0.062	0	0
Co-inhibition by CTLA4	R-HSA-389513	8.664943e-01	0.062	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	8.664943e-01	0.062	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.664943e-01	0.062	0	0
Keratinization	R-HSA-6805567	8.685395e-01	0.061	0	0
Voltage gated Potassium channels	R-HSA-1296072	8.687595e-01	0.061	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	8.737566e-01	0.059	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.767823e-01	0.057	0	0
G-protein activation	R-HSA-202040	8.768338e-01	0.057	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	8.768338e-01	0.057	0	0
Lagging Strand Synthesis	R-HSA-69186	8.768338e-01	0.057	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	8.768338e-01	0.057	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.768338e-01	0.057	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	8.768338e-01	0.057	0	0
Signalling to RAS	R-HSA-167044	8.768338e-01	0.057	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	8.768338e-01	0.057	0	0
ERK/MAPK targets	R-HSA-198753	8.768338e-01	0.057	0	0
Abacavir metabolism	R-HSA-2161541	8.768338e-01	0.057	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	8.768338e-01	0.057	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	8.768338e-01	0.057	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	8.789450e-01	0.056	0	0
Protein localization	R-HSA-9609507	8.801715e-01	0.055	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	8.843502e-01	0.053	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	8.843502e-01	0.053	0	0
Signaling by ALK	R-HSA-201556	8.843502e-01	0.053	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	8.863731e-01	0.052	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	8.863731e-01	0.052	0	0
Attachment and Entry	R-HSA-9694614	8.863731e-01	0.052	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	8.863731e-01	0.052	0	0
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	8.863731e-01	0.052	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	8.863731e-01	0.052	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.877160e-01	0.052	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	8.951741e-01	0.048	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	8.951741e-01	0.048	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.951741e-01	0.048	0	0
Ethanol oxidation	R-HSA-71384	8.951741e-01	0.048	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	8.951741e-01	0.048	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.969945e-01	0.047	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.994391e-01	0.046	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.997433e-01	0.046	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.032362e-01	0.044	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.032939e-01	0.044	0	0
Interleukin receptor SHC signaling	R-HSA-912526	9.032939e-01	0.044	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.032939e-01	0.044	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.032939e-01	0.044	0	0
Formation of the ureteric bud	R-HSA-9830674	9.032939e-01	0.044	0	0
Carnitine shuttle	R-HSA-200425	9.032939e-01	0.044	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.032939e-01	0.044	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.045447e-01	0.044	0	0
Extension of Telomeres	R-HSA-180786	9.052003e-01	0.043	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.052003e-01	0.043	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.065718e-01	0.043	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.107852e-01	0.041	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.107852e-01	0.041	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.107852e-01	0.041	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.107852e-01	0.041	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	9.107852e-01	0.041	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.107852e-01	0.041	0	0
Mitochondrial RNA degradation	R-HSA-9836573	9.107852e-01	0.041	0	0
Complex III assembly	R-HSA-9865881	9.107852e-01	0.041	0	0
TNFs bind their physiological receptors	R-HSA-5669034	9.107852e-01	0.041	0	0
Interleukin-6 family signaling	R-HSA-6783589	9.107852e-01	0.041	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.153149e-01	0.038	0	0
Aquaporin-mediated transport	R-HSA-445717	9.153149e-01	0.038	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.165592e-01	0.038	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.176966e-01	0.037	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	9.176966e-01	0.037	0	0
G protein gated Potassium channels	R-HSA-1296059	9.176966e-01	0.037	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.176966e-01	0.037	0	0
Long-term potentiation	R-HSA-9620244	9.176966e-01	0.037	0	0
Tight junction interactions	R-HSA-420029	9.176966e-01	0.037	0	0
Hyaluronan degradation	R-HSA-2160916	9.176966e-01	0.037	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	9.176966e-01	0.037	0	0
Acyl chain remodelling of PS	R-HSA-1482801	9.176966e-01	0.037	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.176966e-01	0.037	0	0
Formation of the nephric duct	R-HSA-9830364	9.176966e-01	0.037	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.188982e-01	0.037	0	0
Signaling by PDGF	R-HSA-186797	9.199947e-01	0.036	0	0
Proteasome assembly	R-HSA-9907900	9.214043e-01	0.036	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.240730e-01	0.034	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.240730e-01	0.034	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	9.240730e-01	0.034	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.240730e-01	0.034	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.240730e-01	0.034	0	0
TRP channels	R-HSA-3295583	9.240730e-01	0.034	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.240730e-01	0.034	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.244370e-01	0.034	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.263713e-01	0.033	0	0
Somitogenesis	R-HSA-9824272	9.263713e-01	0.033	0	0
Ion transport by P-type ATPases	R-HSA-936837	9.286522e-01	0.032	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.299557e-01	0.032	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	9.299557e-01	0.032	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.299557e-01	0.032	0	0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	9.299557e-01	0.032	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	9.299557e-01	0.032	0	0
Triglyceride biosynthesis	R-HSA-75109	9.299557e-01	0.032	0	0
Maturation of hRSV A proteins	R-HSA-9828806	9.299557e-01	0.032	0	0
Insulin processing	R-HSA-264876	9.299557e-01	0.032	0	0
COPI-mediated anterograde transport	R-HSA-6807878	9.310690e-01	0.031	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.341591e-01	0.030	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	9.353830e-01	0.029	0	0
Prednisone ADME	R-HSA-9757110	9.353830e-01	0.029	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.364411e-01	0.029	0	0
Regulation of insulin secretion	R-HSA-422356	9.374774e-01	0.028	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	9.403900e-01	0.027	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.403900e-01	0.027	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.434239e-01	0.025	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	9.450093e-01	0.025	0	0
DAP12 signaling	R-HSA-2424491	9.450093e-01	0.025	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	9.450093e-01	0.025	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.450093e-01	0.025	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.467315e-01	0.024	0	0
Azathioprine ADME	R-HSA-9748787	9.470590e-01	0.024	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.478734e-01	0.023	0	0
PI Metabolism	R-HSA-1483255	9.487126e-01	0.023	0	0
Trafficking of AMPA receptors	R-HSA-399719	9.492710e-01	0.023	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.492710e-01	0.023	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.492710e-01	0.023	0	0
Adipogenesis	R-HSA-9843745	9.504180e-01	0.022	0	0
Cardiac conduction	R-HSA-5576891	9.504180e-01	0.022	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	9.532025e-01	0.021	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.532025e-01	0.021	0	0
Amino acids regulate mTORC1	R-HSA-9639288	9.566748e-01	0.019	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	9.568296e-01	0.019	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	9.568296e-01	0.019	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	9.594139e-01	0.018	1	0
Potential therapeutics for SARS	R-HSA-9679191	9.597283e-01	0.018	0	0
Miscellaneous transport and binding events	R-HSA-5223345	9.601758e-01	0.018	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.601758e-01	0.018	0	0
Heme degradation	R-HSA-189483	9.601758e-01	0.018	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.606104e-01	0.017	0	0
G alpha (z) signalling events	R-HSA-418597	9.621306e-01	0.017	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.621306e-01	0.017	0	0
Integration of energy metabolism	R-HSA-163685	9.622230e-01	0.017	0	0
Signal amplification	R-HSA-392518	9.632628e-01	0.016	0	0
eNOS activation	R-HSA-203615	9.632628e-01	0.016	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.632628e-01	0.016	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.632628e-01	0.016	0	0
Hyaluronan metabolism	R-HSA-2142845	9.632628e-01	0.016	0	0
Signaling by Insulin receptor	R-HSA-74752	9.636441e-01	0.016	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.646048e-01	0.016	0	0
Neuronal System	R-HSA-112316	9.655778e-01	0.015	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.661107e-01	0.015	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.661107e-01	0.015	0	0
Collagen formation	R-HSA-1474290	9.674617e-01	0.014	0	0
Integrin cell surface interactions	R-HSA-216083	9.688689e-01	0.014	0	0
Cholesterol biosynthesis	R-HSA-191273	9.688689e-01	0.014	0	0
Ion channel transport	R-HSA-983712	9.708999e-01	0.013	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	9.711617e-01	0.013	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.711617e-01	0.013	0	0
Neddylation	R-HSA-8951664	9.721534e-01	0.012	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.724928e-01	0.012	0	0
Potassium Channels	R-HSA-1296071	9.724928e-01	0.012	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.733976e-01	0.012	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.733976e-01	0.012	0	0
Pentose phosphate pathway	R-HSA-71336	9.754604e-01	0.011	0	0
Interleukin-2 family signaling	R-HSA-451927	9.773632e-01	0.010	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.775843e-01	0.010	0	0
Maturation of spike protein	R-HSA-9694548	9.791187e-01	0.009	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.791187e-01	0.009	0	0
Peptide hormone metabolism	R-HSA-2980736	9.798604e-01	0.009	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.807381e-01	0.008	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.807381e-01	0.008	0	0
Intra-Golgi traffic	R-HSA-6811438	9.807381e-01	0.008	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	9.807381e-01	0.008	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.822320e-01	0.008	0	0
Activation of GABAB receptors	R-HSA-991365	9.822320e-01	0.008	0	0
GABA B receptor activation	R-HSA-977444	9.822320e-01	0.008	0	0
DAP12 interactions	R-HSA-2172127	9.848814e-01	0.007	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.848814e-01	0.007	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.848814e-01	0.007	0	0
Surfactant metabolism	R-HSA-5683826	9.848814e-01	0.007	0	0
Platelet homeostasis	R-HSA-418346	9.853611e-01	0.006	0	0
Neurotransmitter release cycle	R-HSA-112310	9.860964e-01	0.006	0	0
Parasite infection	R-HSA-9664407	9.867354e-01	0.006	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.867354e-01	0.006	0	0
Leishmania phagocytosis	R-HSA-9664417	9.867354e-01	0.006	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.871360e-01	0.006	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.873951e-01	0.006	0	0
ECM proteoglycans	R-HSA-3000178	9.873951e-01	0.006	0	0
Synthesis of PC	R-HSA-1483191	9.881340e-01	0.005	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.882466e-01	0.005	0	0
Intraflagellar transport	R-HSA-5620924	9.890547e-01	0.005	0	0
Metal ion SLC transporters	R-HSA-425410	9.890547e-01	0.005	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.897151e-01	0.004	0	0
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.899039e-01	0.004	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.904781e-01	0.004	0	0
G alpha (q) signalling events	R-HSA-416476	9.906588e-01	0.004	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.906873e-01	0.004	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.914100e-01	0.004	0	0
Complex IV assembly	R-HSA-9864848	9.914100e-01	0.004	0	0
The phototransduction cascade	R-HSA-2514856	9.914100e-01	0.004	0	0
Extracellular matrix organization	R-HSA-1474244	9.915295e-01	0.004	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.926915e-01	0.003	0	0
Paracetamol ADME	R-HSA-9753281	9.937820e-01	0.003	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.942646e-01	0.002	0	0
PPARA activates gene expression	R-HSA-1989781	9.943614e-01	0.002	0	0
Dectin-2 family	R-HSA-5621480	9.947099e-01	0.002	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.949466e-01	0.002	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.951205e-01	0.002	0	0
Leishmania infection	R-HSA-9658195	9.954992e-01	0.002	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.954992e-01	0.002	0	0
Triglyceride metabolism	R-HSA-8979227	9.954994e-01	0.002	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.954994e-01	0.002	0	0
RAB geranylgeranylation	R-HSA-8873719	9.958488e-01	0.002	0	0
GABA receptor activation	R-HSA-977443	9.958488e-01	0.002	0	0
tRNA Aminoacylation	R-HSA-379724	9.958488e-01	0.002	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.958488e-01	0.002	0	0
Metabolism of polyamines	R-HSA-351202	9.958488e-01	0.002	0	0
Collagen degradation	R-HSA-1442490	9.961711e-01	0.002	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.964684e-01	0.002	0	0
Complex I biogenesis	R-HSA-6799198	9.967427e-01	0.001	0	0
Transmission across Chemical Synapses	R-HSA-112315	9.968891e-01	0.001	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.969518e-01	0.001	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	9.970475e-01	0.001	0	0
Nicotinate metabolism	R-HSA-196807	9.976427e-01	0.001	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.976427e-01	0.001	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.977156e-01	0.001	0	0
G alpha (s) signalling events	R-HSA-418555	9.978158e-01	0.001	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.978258e-01	0.001	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.978749e-01	0.001	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.982902e-01	0.001	0	0
Metabolism of cofactors	R-HSA-8978934	9.982942e-01	0.001	0	0
Retinoid metabolism and transport	R-HSA-975634	9.982942e-01	0.001	0	0
Metabolism of porphyrins	R-HSA-189445	9.982942e-01	0.001	0	0
Purine catabolism	R-HSA-74259	9.984267e-01	0.001	0	0
Interferon gamma signaling	R-HSA-877300	9.985562e-01	0.001	0	0
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.986617e-01	0.001	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.986617e-01	0.001	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.989501e-01	0.000	0	0
Post-translational protein modification	R-HSA-597592	9.989594e-01	0.000	1	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.990317e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.992404e-01	0.000	0	0
Metabolism of proteins	R-HSA-392499	9.994795e-01	0.000	1	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.996025e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.996296e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.996593e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.998082e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.998496e-01	0.000	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.998603e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.998613e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.998650e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.998657e-01	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	9.998929e-01	0.000	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.999076e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.999173e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.999276e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999424e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999426e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.999476e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999517e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999614e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999651e-01	0.000	0	0
Drug ADME	R-HSA-9748784	9.999694e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999754e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.999754e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999770e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999793e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	9.999842e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999845e-01	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	9.999845e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999868e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999882e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999912e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999931e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999931e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.999950e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999972e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999980e-01	0.000	0	0
Complement cascade	R-HSA-166658	9.999981e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999983e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999987e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.999989e-01	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999993e-01	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999994e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999994e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999996e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999996e-01	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999999e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999999e-01	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0