MLK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0	T949	Sugiyama	POTEF A26C1B	TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
O14950	T160	Sugiyama	MYL12B MRLC2 MYLC2B	DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
O15371	T49	Sugiyama	EIF3D EIF3S7	PyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGGSQY
O43707	T359	Sugiyama	ACTN4	RRVHKPPKVQEKCQLEINFNtLQtKLRLSNRPAFMPSEGKM
O43707	T362	Sugiyama	ACTN4	HKPPKVQEKCQLEINFNtLQtKLRLSNRPAFMPSEGKMVSD
O43852	S261	Sugiyama	CALU	RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O43852	S44	Sugiyama	CALU	KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O43852	S69	Sugiyama	CALU	HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O43852	T196	Sugiyama	CALU	FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O43852	T89	Sugiyama	CALU	sKERLGKIVSKIDGDKDGFVtVDELKDWIKFAQKRWIyEDV
O60220	S94	Sugiyama	TIMM8A DDP DDP1 TIM8A	SQFILNRLEQTQKSKPVFSEsLsD_________________
O60841	S196	Sugiyama	EIF5B IF2 KIAA0741	ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O75347	S103	Sugiyama	TBCA	ENEKDLEEAEEyKEARLVLDsVKLEA_______________
O75821	T27	Sugiyama	EIF3G EIF3S4	DsKPsWADQVEEEGEDDKCVtsELLKGIPLAtGDtsPEPEL
P00338	S167	Sugiyama	LDHA PIG19	AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG
P00558	S393	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	GGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDA
P00558	T369	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	ARGTKALMDEVVKAtsRGCItIIGGGDtAtCCAKWNtEDKV
P00558	T376	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	MDEVVKAtsRGCItIIGGGDtAtCCAKWNtEDKVsHVstGG
P00558	T394	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P04040	S515	Sugiyama	CAT	ALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL________
P04040	T28	Sugiyama	CAT	ASDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRG
P04040	T29	Sugiyama	CAT	SDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRGP
P04040	T511	Sugiyama	CAT	SHIQALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL____
P04075	S17	Sugiyama	ALDOA ALDA	____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S360	Sugiyama	ALDOA ALDA	QGKytPsGQAGAAAsEsLFVsNHAy________________
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075	Y364	Sugiyama	ALDOA ALDA	tPsGQAGAAAsEsLFVsNHAy____________________
P04083	T169	Sugiyama	ANXA1 ANX1 LPC1	IRDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRs
P04083	T172	Sugiyama	ANXA1 ANX1 LPC1	INRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDF
P04083	T223	Sugiyama	ANXA1 ANX1 LPC1	ARALyEAGERRKGtDVNVFNtILttRSyPQLRRVFQKYTKY
P04083	T226	Sugiyama	ANXA1 ANX1 LPC1	LyEAGERRKGtDVNVFNtILttRSyPQLRRVFQKYTKYSKH
P04181	T39	Sugiyama	OAT	HSSVASATSVATKKtVQGPPtSDDIFEREyKyGAHNyHPLP
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	S25	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	KVGVNGFGRIGRLVtRAAFNsGKVDIVAINDPFIDLNyMVY
P04406	S312	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA
P04406	S321	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE______
P04406	T153	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	MGVNHEKYDNSLKIIsNAsCttNCLAPLAKVIHDNFGIVEG
P04406	T154	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GVNHEKYDNSLKIIsNAsCttNCLAPLAKVIHDNFGIVEGL
P04406	T19	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	__MGKVKVGVNGFGRIGRLVtRAAFNsGKVDIVAINDPFID
P04406	T246	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04406	Y314	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	tFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsK
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P04792	T174	Sugiyama	HSPB1 HSP27 HSP28	SSsLsPEGtLTVEAPMPKLAtQsNEItIPVtFEsRAQLGGP
P04792	T184	Sugiyama	HSPB1 HSP27 HSP28	TVEAPMPKLAtQsNEItIPVtFEsRAQLGGPEAAKsDETAA
P05198	T279	Sugiyama	EIF2S1 EIF2A	KEKIEEKRGVFNVQMEPKVVtDtDEtELARQMERLERENAE
P05198	T281	Sugiyama	EIF2S1 EIF2A	KIEEKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVD
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05455	S325	Sugiyama	SSB	VLEGEVEKEALKKIIEDQQEsLNKWKSKGRRFKGKGKGNKA
P05783	S93	Sugiyama	KRT18 CYK18 PIG46	GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P05787	S291	Sugiyama	KRT8 CYK8	ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P05787	S410	Sugiyama	KRT8 CYK8	TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL
P06733	S14	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	_______MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAA
P06733	S291	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	IsPDQLADLyKsFIKDyPVVsIEDPFDQDDWGAWQKFtAsA
P06733	S37	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06733	S40	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	VEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGK
P06733	T19	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	__MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGA
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733	T26	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P06733	T41	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P06748	S137	Sugiyama	NPM1 NPM	VAVEEDAEsEDEEEEDVKLLsIsGKRsAPGGGsKVPQKKVK
P07195	S168	Sugiyama	LDHB	TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG
P07205	S393	Sugiyama	PGK2 PGKB	GGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEA
P07205	T394	Sugiyama	PGK2 PGKB	GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07237	S439	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	NIVIAKMDstANEVEAVKVHsFPtLKFFPAsADRtVIDyNG
P07237	T442	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	IAKMDstANEVEAVKVHsFPtLKFFPAsADRtVIDyNGERt
P07437	S115	Sugiyama	TUBB TUBB5 OK/SW-cl.56	sGAGNNWAKGHytEGAELVDsVLDVVRKEAESCDCLQGFQL
P07437	S75	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07437	T107	Sugiyama	TUBB TUBB5 OK/SW-cl.56	PDNFVFGQsGAGNNWAKGHytEGAELVDsVLDVVRKEAESC
P07437	T72	Sugiyama	TUBB TUBB5 OK/SW-cl.56	NEAtGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07737	T65	Sugiyama	PFN1	PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737	Y60	Sugiyama	PFN1	FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07814	S1473	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	CEDWIKKtTARDQDLEPGAPsMGAKSLCIPFKPLCELQPGA
P07814	S335	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07864	S167	Sugiyama	LDHC LDH3 LDHX	VWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVHPTSCHG
P07900	S165	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900	S468	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	GIHEDsQNRKKLsELLRyytsAsGDEMVsLKDYCTRMKENQ
P07900	S50	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900	S505	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	KENQKHIyyItGETKDQVANsAFVERLRKHGLEVIyMIEPI
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	T171	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	ITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTKVILHLK
P07900	T195	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900	T495	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	VsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLRKHG
P07900	Y492	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DEMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLR
P07900	Y493	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	EMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLRK
P08195	S598	Sugiyama	SLC3A2 MDU1	LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195	T599	Sugiyama	SLC3A2 MDU1	QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238	S160	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238	S45	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S48	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238	S497	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08238	T166	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	ITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTKVILHLK
P08238	T190	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08708	S89	Sugiyama	RPS17 RPS17L	ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P08708	T102	Sugiyama	RPS17 RPS17L	DNyVPEVsALDQEIIEVDPDtKEMLKLLDFGsLsNLQVtQP
P09104	S37	Sugiyama	ENO2	NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY
P09104	S40	Sugiyama	ENO2	VEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGK
P09104	T41	Sugiyama	ENO2	EVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKG
P09132	S69	Sugiyama	SRP19	IQDVCSAVGLNVFLEKNKMYsREWNRDVQYRGRVRVQLKQE
P09234	T14	Sugiyama	SNRPC	_______MPKFyCDyCDtyLtHDsPsVRKTHCSGRKHKENV
P09382	S63	Sugiyama	LGALS1	CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09661	S212	Sugiyama	SNRPA1	KKGGPsPGDVEAIKNAIANAstLAEVERLKGLLQsGQIPGR
P09661	T213	Sugiyama	SNRPA1	KGGPsPGDVEAIKNAIANAstLAEVERLKGLLQsGQIPGRE
P09972	T123	Sugiyama	ALDOC ALDC	IVVGIKVDKGVVPLAGtDGEtttQGLDGLsERCAQYKKDGA
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7	S54	Sugiyama	TUBA3C TUBA2	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P0DPH7	T73	Sugiyama	TUBA3C TUBA2	FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
P0DPH7	T80	Sugiyama	TUBA3C TUBA2	KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAA
P10412	S41	Sugiyama	H1-4 H1F4 HIST1H1E	KKKARKsAGAAKRKAsGPPVsELItKAVAASKERsGVsLAA
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412	T45	Sugiyama	H1-4 H1F4 HIST1H1E	RKsAGAAKRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P10809	T428	Sugiyama	HSPD1 HSP60	GtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGCALLRCI
P11142	S85	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	NtVFDAKRLIGRRFDDAVVQsDMKHWPFMVVNDAGRPKVQV
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T37	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142	T425	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	TAGGVMTVLIKRNtTIPTKQtQtFttysDNQPGVLIQVyEG
P11142	T427	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	GGVMTVLIKRNtTIPTKQtQtFttysDNQPGVLIQVyEGER
P11142	T45	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P11142	T47	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtNtV
P11142	T64	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11586	T128	Sugiyama	MTHFD1 MTHFC MTHFD	SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P11940	T191	Sugiyama	PABPC1 PAB1 PABP PABP1 PABPC2	GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P11940	T379	Sugiyama	PABPC1 PAB1 PABP PABP1 PABPC2	AtKPLyVALAQRKEERQAHLtNQyMQRMASVRAVPNPVINP
P12814	T340	Sugiyama	ACTN1	RRLHKPPKVQEKCQLEINFNtLQtKLRLsNRPAFMPsEGRM
P12814	T343	Sugiyama	ACTN1	HKPPKVQEKCQLEINFNtLQtKLRLsNRPAFMPsEGRMVSD
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639	S38	Sugiyama	EEF2 EF2	NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639	S578	Sugiyama	EEF2 EF2	LKDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNK
P13639	S584	Sugiyama	EEF2 EF2	DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13639	S587	Sugiyama	EEF2 EF2	CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13639	S593	Sugiyama	EEF2 EF2	SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639	T5	Sugiyama	EEF2 EF2	________________MVNFtVDQIRAIMDKKANIRNMsVI
P13639	T582	Sugiyama	EEF2 EF2	EEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRL
P13639	Y579	Sugiyama	EEF2 EF2	KDLEEDHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKH
P13667	S379	Sugiyama	PDIA4 ERP70 ERP72	QPEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGH
P13688	S508	EPSD	CEACAM1 BGP BGP1	MNEVtysTLNFEAQQPTQPTsASPsLTATEIIySEVKKQ__
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P13929	S37	Sugiyama	ENO3	NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY
P13929	S40	Sugiyama	ENO3	VEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGK
P13929	T19	Sugiyama	ENO3	__MAMQKIFAREILDsRGNPtVEVDLHtAKGRFRAAVPsGA
P13929	T26	Sugiyama	ENO3	IFAREILDsRGNPtVEVDLHtAKGRFRAAVPsGAstGIyEA
P13929	T41	Sugiyama	ENO3	EVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKG
P14314	T134	Sugiyama	PRKCSH G19P1	NtCKEKGRKEREsLQQMAEVtREGFRLKKILIEDWKKAREE
P14618	S205	Sugiyama	PKM OIP3 PK2 PK3 PKM2	VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14618	S77	Sugiyama	PKM OIP3 PK2 PK3 PKM2	sVEtLKEMIKsGMNVARLNFsHGtHEyHAEtIKNVRtAtEs
P14618	S97	Sugiyama	PKM OIP3 PK2 PK3 PKM2	sHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGP
P14618	T195	Sugiyama	PKM OIP3 PK2 PK3 PKM2	yVDDGLISLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAA
P14618	T454	Sugiyama	PKM OIP3 PK2 PK3 PKM2	SGRSAHQVARYRPRAPIIAVtRNPQtARQAHLYRGIFPVLC
P14618	T459	Sugiyama	PKM OIP3 PK2 PK3 PKM2	HQVARYRPRAPIIAVtRNPQtARQAHLYRGIFPVLCKDPVQ
P14618	T87	Sugiyama	PKM OIP3 PK2 PK3 PKM2	sGMNVARLNFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRP
P14625	S106	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625	S109	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625	S514	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625	S64	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625	T675	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	sGNMERIMKAQAYQtGKDIstNyyAsQKKTFEINPRHPLIR
P14649	T101	Sugiyama	MYL6B MLC1SA	DGKILysQCGDVMRALGQNPtNAEVLKVLGNPKsDELKSRR
P15311	S539	Sugiyama	EZR VIL2	TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15880	S206	Sugiyama	RPS2 RPS4	GRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDCytsA
P15880	T285	Sugiyama	RPS2 RPS4	PyQEFtDHLVKtHtRVsVQRtQAPAVATt____________
P15923	S341	SIGNOR\|EPSD\|PSP	TCF3 BHLHB21 E2A ITF1	RGTTAGSsGDALGKALAsIysPDHssNNFsssPstPVGsPQ
P15923	S352	SIGNOR\|EPSD\|PSP	TCF3 BHLHB21 E2A ITF1	LGKALAsIysPDHssNNFsssPstPVGsPQGLAGTSQWPRA
P15923	S359	SIGNOR\|EPSD\|PSP	TCF3 BHLHB21 E2A ITF1	IysPDHssNNFsssPstPVGsPQGLAGTSQWPRAGAPGALs
P15923	S379	SIGNOR\|EPSD\|PSP	TCF3 BHLHB21 E2A ITF1	sPQGLAGTSQWPRAGAPGALsPsYDGGLHGLQsKIEDHLDE
P15923	T355	SIGNOR\|EPSD\|PSP	TCF3 BHLHB21 E2A ITF1	ALAsIysPDHssNNFsssPstPVGsPQGLAGTSQWPRAGAP
P16402	S42	Sugiyama	H1-3 H1F3 HIST1H1D	KKAKKAGATAGKRKAsGPPVsELItKAVAASKERsGVsLAA
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402	T46	Sugiyama	H1-3 H1F3 HIST1H1D	KAGATAGKRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P16403	S41	Sugiyama	H1-2 H1F2 HIST1H1C	KKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsGVsLAA
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	T45	Sugiyama	H1-2 H1F2 HIST1H1C	AKKAGGtPRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P17066	T228	Sugiyama	HSPA6 HSP70B'	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17066	T47	Sugiyama	HSPA6 HSP70B'	RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17987	S551	Sugiyama	TCP1 CCT1 CCTA	IKLHPESKDDKHGsyEDAVHsGALND_______________
P18077	S90	Sugiyama	RPL35A GIG33	IWGKVTRAHGNSGMVRAKFRsNLPAKAIGHRIRVMLyPSRI
P18621	S14	Sugiyama	RPL17	_______MVRysLDPENPtKsCKSRGSNLRVHFKNtRETAQ
P18621	T12	Sugiyama	RPL17	_________MVRysLDPENPtKsCKSRGSNLRVHFKNtRET
P18669	S152	Sugiyama	PGAM1 PGAMA CDABP0006	FysNIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIV
P18669	S155	Sugiyama	PGAM1 PGAMA CDABP0006	NIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQI
P18669	T159	Sugiyama	PGAM1 PGAMA CDABP0006	DRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQIKEGK
P19105	T159	Sugiyama	MYL12A MLCB MRLC3 RLC	DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
P19338	S356	Sugiyama	NCL	LAVVDVRIGMTRKFGyVDFEsAEDLEKALELtGLKVFGNEI
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338	S619	Sugiyama	NCL	RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P19338	T464	Sugiyama	NCL	KTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWsGE
P20042	S67	Sugiyama	EIF2S2 EIF2B	EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK
P22314	S56	Sugiyama	UBA1 A1S9T UBE1	VPTNGMAKNGsEADIDEGLysRQLyVLGHEAMKRLQTSSVL
P23396	S35	Sugiyama	RPS3 OK/SW-cl.26	GIFKAELNEFLtRELAEDGysGVEVRVtPTRTEIIILATRT
P23396	T26	Sugiyama	RPS3 OK/SW-cl.26	sKKRKFVADGIFKAELNEFLtRELAEDGysGVEVRVtPTRT
P23528	T63	Sugiyama	CFL1 CFL	DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528	T70	Sugiyama	CFL1 CFL	EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23528	T91	Sugiyama	CFL1 CFL	FVKMLPDKDCRyALyDAtyEtKESKKEDLVFIFWAPESAPL
P23588	S122	Sugiyama	EIF4B	NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P24752	T220	Sugiyama	ACAT1 ACAT MAT	TAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPVtV
P25205	S34	Sugiyama	MCM3	EAQRDyLDFLDDEEDQGIyQsKVRELIsDNQyRLIVNVNDL
P25786	T11	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	__________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26038	S536	Sugiyama	MSN	ERVQKHLKALtsELANARDEsKKTANDMIHAENMRLGRDKY
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373	S97	Sugiyama	RPL13 BBC1 OK/SW-cl.46	sLEELRVAGIHKKVARTIGIsVDPRRRNKstEsLQANVQRL
P26373	T148	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373	T151	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26641	T287	Sugiyama	EEF1G EF1G PRO1608	EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27348	T30	Sugiyama	YWHAQ	AKLAEQAERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKN
P27797	S52	Sugiyama	CALR CRTC	GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29401	T444	Sugiyama	TKT	DGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAANT
P29692	S44	Sugiyama	EEF1D EF1D	RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692	T129	Sugiyama	EEF1D EF1D	EARLNVLEKssPGHRAtAPQtQHVsPMRQVEPPAKKPAtPA
P29692	T73	Sugiyama	EEF1D EF1D	ARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVENQs
P30041	S186	Sugiyama	PRDX6 AOP2 KIAA0106	SLQLTAEKRVAtPVDWKDGDsVMVLPtIPEEEAKKLFPKGV
P30041	T192	Sugiyama	PRDX6 AOP2 KIAA0106	EKRVAtPVDWKDGDsVMVLPtIPEEEAKKLFPKGVFtKELP
P30041	T48	Sugiyama	PRDX6 AOP2 KIAA0106	FLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKRNVKL
P30041	T95	Sugiyama	PRDX6 AOP2 KIAA0106	SVEDHLAWSKDINAyNCEEPtEKLPFPIIDDRNRELAILLG
P30043	S202	Sugiyama	BLVRB FLR SCAN	GHFMLRCLttDEyDGHstyPsHQyQ________________
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30050	S157	Sugiyama	RPL12	QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30050	T135	Sugiyama	RPL12	QMRHRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDI
P30050	T25	Sugiyama	RPL12	FDPNEIKVVYLRCtGGEVGAtsALAPKIGPLGLsPKKVGDD
P30085	S180	Sugiyama	CMPK1 CMK CMPK UCK UMK UMPK	KPIIDLyEEMGKVKKIDASKsVDEVFDEVVQIFDKEG____
P30086	S139	Sugiyama	PEBP1 PBP PEBP	RyVWLVyEQDRPLKCDEPILsNRsGDHRGKFKVAsFRKKyE
P30086	S60	Sugiyama	PEBP1 PBP PEBP	VLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPK
P30086	T167	Sugiyama	PEBP1 PBP PEBP	GKFKVAsFRKKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK
P30101	S474	Sugiyama	PDIA3 ERP57 ERP60 GRP58	yFsPANKKLNPKKyEGGRELsDFIsyLQREAtNPPVIQEEK
P30101	S478	Sugiyama	PDIA3 ERP57 ERP60 GRP58	ANKKLNPKKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKK
P30101	T437	Sugiyama	PDIA3 ERP57 ERP60 GRP58	KELGEKLsKDPNIVIAKMDAtANDVPsPyEVRGFPtIyFsP
P30419	T134	Sugiyama	NMT1 NMT	KRSyQFWDtQPVPKLGEVVNtHGPVEPDKDNIRQEPYTLPQ
P31327	T326	Sugiyama	CPS1	AKTYKMSMANRGQNQPVLNItNKQAFITAQNHGYALDNTLP
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31946	T32	Sugiyama	YWHAB	AKLAEQAERyDDMAAAMKAVtEQGHELsNEERNLLsVAyKN
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P31948	S16	Sugiyama	STIP1	_____MEQVNELKEKGNKALsVGNIDDALQCysEAIKLDPH
P31948	S28	Sugiyama	STIP1	KEKGNKALsVGNIDDALQCysEAIKLDPHNHVLysNRsAAy
P32119	T142	Sugiyama	PRDX2 NKEFB TDPX1	EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P33176	S443	Sugiyama	KIF5B KNS KNS1	EEIAKLYKQLDDKDEEINQQsQLVEKLKTQMLDQEELLAST
P33316	S164	Sugiyama	DUT	YTIPPMEKAVVKTDIQIALPsGCyGRVAPRSGLAAKHFIDV
P34897	S76	Sugiyama	SHMT2	MWELLQREKDRQCRGLELIAsENFCsRAALEALGsCLNNKY
P34897	S81	Sugiyama	SHMT2	QREKDRQCRGLELIAsENFCsRAALEALGsCLNNKYSEGYP
P34931	T228	Sugiyama	HSPA1L	DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931	T39	Sugiyama	HSPA1L	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34931	T47	Sugiyama	HSPA1L	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P34931	T49	Sugiyama	HSPA1L	EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQNTV
P35579	S1892	Sugiyama	MYH9	LKQLKRQLEEAEEEAQRANAsRRKLQRELEDAtEtADAMNR
P35609	T347	Sugiyama	ACTN2	RRKHKPPKVQEKCQLEINFNtLQtKLRISNRPAFMPSEGKM
P35609	T350	Sugiyama	ACTN2	HKPPKVQEKCQLEINFNtLQtKLRISNRPAFMPSEGKMVSD
P36578	S87	Sugiyama	RPL4 RPL1	WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578	T84	Sugiyama	RPL4 RPL1	AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P37108	S6	Sugiyama	SRP14	_______________MVLLEsEQFLtELTRLFQKCRTSGsV
P37108	T11	Sugiyama	SRP14	__________MVLLEsEQFLtELTRLFQKCRTSGsVyItLK
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37802	T190	Sugiyama	TAGLN2 KIAA0120 CDABP0035	GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P38646	S549	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	IVHVSAKDKGTGREQQIVIQssGGLsKDDIENMVKNAEKYA
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646	T120	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646	T398	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P38646	T86	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38646	T94	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	QAKVLENAEGARttPsVVAFtADGERLVGMPAKRQAVtNPN
P39019	S59	Sugiyama	RPS19	LAKHKELAPyDENWFytRAAstARHLYLRGGAGVGsMTKIY
P39019	S93	Sugiyama	RPS19	GsMTKIYGGRQRNGVMPsHFsRGsKsVARRVLQALEGLKMV
P39019	T55	Sugiyama	RPS19	DtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGsM
P39019	T60	Sugiyama	RPS19	AKHKELAPyDENWFytRAAstARHLYLRGGAGVGsMTKIYG
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P40429	T153	Sugiyama	RPL13A	RKFAYLGRLAHEVGWKyQAVtAtLEEKRKEKAKIHYRKKKQ
P40429	T155	Sugiyama	RPL13A	FAYLGRLAHEVGWKyQAVtAtLEEKRKEKAKIHYRKKKQLM
P42677	S78	Sugiyama	RPS27 MPS1	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
P43034	S152	Sugiyama	PAFAH1B1 LIS1 MDCR MDS PAFAHA	IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46776	T72	Sugiyama	RPL27A	yFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRVNAAK
P46777	S172	Sugiyama	RPL5 MSTP030	RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777	S176	Sugiyama	RPL5 MSTP030	GNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHR
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46777	T177	Sugiyama	RPL5 MSTP030	NKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHRK
P46783	S146	Sugiyama	RPS10	TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P47756	T202	Sugiyama	CAPZB	SGsGtMNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMEN
P47914	S142	Sugiyama	RPL29	KAKAKAKAKDQTKAQAAAPAsVPAQAPKRtQAPtKAsE___
P48741	T228	Sugiyama	HSPA7 HSP70B	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P48741	T47	Sugiyama	HSPA7 HSP70B	RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49321	S662	Sugiyama	NASP	LKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsstsGF
P49327	S265	Sugiyama	FASN FAS	TILNAGTNTDGFKEQGVtFPsGDIQEQLIRSLyQsAGVAPE
P49327	T2215	Sugiyama	FASN FAS	DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49368	S212	Sugiyama	CCT3 CCTG TRIC5	EIDIKKYARVEKIPGGIIEDsCVLRGVMINKDVTHPRMRRY
P50395	S401	Sugiyama	GDI2 RABGDIB	VsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDDIKNIY
P50395	T407	Sugiyama	GDI2 RABGDIB	LVPKDLGtEsQIFIsRTyDAttHFEttCDDIKNIYKRMtGs
P50395	T412	Sugiyama	GDI2 RABGDIB	LGtEsQIFIsRTyDAttHFEttCDDIKNIYKRMtGsEFDFE
P50454	S139	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P50502	S181	Sugiyama	ST13 AAG2 FAM10A1 HIP SNC6	LQKPNAAIRDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
P50897	T265	Sugiyama	PPT1 CLN1 PPT	GFYRsGQAKEtIPLQEtsLytQDRLGLKEMDNAGQLVFLAT
P50990	T286	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	MNFsKGEENLMDAQVKAIADtGANVVVtGGKVADMALHYAN
P50990	T293	Sugiyama	CCT8 C21orf112 CCTQ KIAA0002	ENLMDAQVKAIADtGANVVVtGGKVADMALHYANKYNIMLV
P51149	T168	Sugiyama	RAB7A RAB7	NIPyFEtSAKEAINVEQAFQtIARNALKQETEVELyNEFPE
P51858	S83	Sugiyama	HDGF HMG1L2	LFPyEEsKEKFGKPNKRKGFsEGLWEIENNPtVKASGYQSs
P51858	T94	Sugiyama	HDGF HMG1L2	GKPNKRKGFsEGLWEIENNPtVKASGYQSsQKKsCVEEPEP
P51991	S375	Sugiyama	HNRNPA3 HNRPA3	ssGsPyGGGyGsGGGsGGyGsRRF_________________
P53999	S118	Sugiyama	SUB1 PC4 RPO2TC1	PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652	T38	Sugiyama	HSPA2	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P54652	T46	Sugiyama	HSPA2	KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P54652	T48	Sugiyama	HSPA2	EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTNTI
P57721	S82	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK
P60174	T217	Sugiyama	TPI1 TPI	VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174	T38	Sugiyama	TPI1 TPI	RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60174	T46	Sugiyama	TPI1 TPI	IGtLNAAKVPADtEVVCAPPtAyIDFARQKLDPKIAVAAQN
P60660	T44	Sugiyama	MYL6	DGKILysQCGDVMRALGQNPtNAEVLKVLGNPKsDEMNVKV
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709	S60	Sugiyama	ACTB	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709	T106	Sugiyama	ACTB	WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709	T202	Sugiyama	ACTB	GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P60709	T249	Sugiyama	ACTB	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709	T318	Sugiyama	ACTB	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709	Y53	Sugiyama	ACTB	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61221	Y594	Sugiyama	ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40	RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61247	S237	Sugiyama	RPS3A FTE1 MFTL	MLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyE
P61247	S238	Sugiyama	RPS3A FTE1 MFTL	LKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyEP
P61247	S263	Sugiyama	RPS3A FTE1 MFTL	GDEtGAKVERADGyEPPVQEsV___________________
P61254	T8	Sugiyama	RPL26	_____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61313	S100	Sugiyama	RPL15 EC45 TCBAP0781	tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61353	S39	Sugiyama	RPL27	SGRKAVIVKNIDDGtsDRPysHALVAGIDRyPRKVTAAMGK
P61604	S64	Sugiyama	HSPE1	AtVVAVGsGsKGKGGEIQPVsVKVGDKVLLPEyGGtKVVLD
P61978	S81	Sugiyama	HNRNPK HNRPK	GGKNIKALRtDyNAsVsVPDssGPERILsISADIETIGEIL
P61981	S38	Sugiyama	YWHAG	ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P61981	T31	Sugiyama	YWHAG	ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62266	S45	Sugiyama	RPS23	KQYKKAHLGtALKANPFGGAsHAKGIVLEKVGVEAKQPNSA
P62269	S96	Sugiyama	RPS18 D6S218E	QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62269	T60	Sugiyama	RPS18 D6S218E	YAHVVLRKADIDLTKRAGELtEDEVERVItIMQNPRQYKIP
P62269	T69	Sugiyama	RPS18 D6S218E	DIDLTKRAGELtEDEVERVItIMQNPRQYKIPDWFLNRQKD
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	T28	Sugiyama	RPS11	RAyQKQPtIFQNKKRVLLGEtGKEKLPRYYKNIGLGFKtPK
P62280	T54	Sugiyama	RPS11	PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62316	T40	Sugiyama	SNRPD2 SNRPD1	EEEEFNtGPLsVLtQsVKNNtQVLINCRNNKKLLGRVKAFD
P62318	T19	Sugiyama	SNRPD3	__MSIGVPIKVLHEAEGHIVtCEtNTGEVYRGKLIEAEDNM
P62318	T22	Sugiyama	SNRPD3	SIGVPIKVLHEAEGHIVtCEtNTGEVYRGKLIEAEDNMNCQ
P62701	T177	Sugiyama	RPS4X CCG2 RPS4 SCAR	NDtIQIDLEtGKITDFIKFDtGNLCMVtGGANLGRIGVITN
P62701	T184	Sugiyama	RPS4X CCG2 RPS4 SCAR	LEtGKITDFIKFDtGNLCMVtGGANLGRIGVITNRERHPGs
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	S62	Sugiyama	ACTA2 ACTSA ACTVS GIG46	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736	T251	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736	T320	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736	Y55	Sugiyama	ACTA2 ACTSA ACTVS GIG46	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62826	T66	Sugiyama	RAN ARA24 OK/SW-cl.81	EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62899	T107	Sugiyama	RPL31	RLSRKRNEDEDsPNKLytLVtyVPVttFKNLQtVNVDEN__
P62899	T113	Sugiyama	RPL31	NEDEDsPNKLytLVtyVPVttFKNLQtVNVDEN________
P62899	T22	Sugiyama	RPL31	APAKKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRA
P62899	T26	Sugiyama	RPL31	KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62899	Y108	Sugiyama	RPL31	LSRKRNEDEDsPNKLytLVtyVPVttFKNLQtVNVDEN___
P62917	S130	Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917	S138	Sugiyama	RPL8	EKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVI
P62917	T135	Sugiyama	RPL8	CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917	T143	Sugiyama	RPL8	RGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANR
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942	T22	Sugiyama	FKBP1A FKBP1 FKBP12	GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62942	T28	Sugiyama	FKBP1A FKBP1 FKBP12	IsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPFK
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62942	Y27	Sugiyama	FKBP1A FKBP1 FKBP12	tIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPF
P62979	S123	Sugiyama	RPS27A UBA80 UBCEP1	LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P62979	S134	Sugiyama	RPS27A UBA80 UBCEP1	IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P62979	T147	Sugiyama	RPS27A UBA80 UBCEP1	GAGVFMAsHFDRHyCGKCCLtyCFNKPEDK___________
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63167	S21	Sugiyama	DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1	MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH
P63167	T26	Sugiyama	DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1	AVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAHIKKEF
P63173	T14	Sugiyama	RPL38	_______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261	S60	Sugiyama	ACTG1 ACTG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261	T106	Sugiyama	ACTG1 ACTG	WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261	T202	Sugiyama	ACTG1 ACTG	GRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALD
P63261	T249	Sugiyama	ACTG1 ACTG	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261	T318	Sugiyama	ACTG1 ACTG	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261	Y53	Sugiyama	ACTG1 ACTG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	S61	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267	T250	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267	T319	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267	Y54	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809	S102	Sugiyama	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809	S209	Sugiyama	YBX1 NSEP1 YB1	RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S62	Sugiyama	ACTC1 ACTC	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032	T251	Sugiyama	ACTC1 ACTC	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032	T320	Sugiyama	ACTC1 ACTC	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032	Y55	Sugiyama	ACTC1 ACTC	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S62	Sugiyama	ACTA1 ACTA	HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133	T251	Sugiyama	ACTA1 ACTA	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133	T320	Sugiyama	ACTA1 ACTA	VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	Y55	Sugiyama	ACTA1 ACTA	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363	S54	Sugiyama	TUBA1B	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	T80	Sugiyama	TUBA1B	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P68363	T82	Sugiyama	TUBA1B	VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
P68363	Y83	Sugiyama	TUBA1B	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P78371	T246	Sugiyama	CCT2 99D8.1 CCTB	VNQPKRIENAKILIANtGMDtDKIKIFGsRVRVDstAKVAE
P83731	S7	Sugiyama	RPL24	______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731	S86	Sugiyama	RPL24	EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731	T83	Sugiyama	RPL24	QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098	T29	Sugiyama	RPL19	RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
P99999	S48	Sugiyama	CYCS CYC	KTGPNLHGLFGRKtGQAPGysytAANKNKGIIWGEDTLMEY
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01082	T1386	Sugiyama	SPTBN1 SPTB2	ESTTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSD
Q01105	S133	Sugiyama	SET	DEEALHYLTRVEVtEFEDIKsGyRIDFyFDENPyFENKVLS
Q01105	S165	Sugiyama	SET	PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q01105	S166	Sugiyama	SET	yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105	S168	Sugiyama	SET	ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105	S63	Sugiyama	SET	EAIEHIDEVQNEIDRLNEQAsEEILKVEQKYNKLRQPFFQK
Q02543	T107	Sugiyama	RPL18A	RSGtHNMYREyRDLttAGAVtQCyRDMGARHRARAHsIQIM
Q02543	Y97	Sugiyama	RPL18A	NFGIWLRYDsRSGtHNMYREyRDLttAGAVtQCyRDMGARH
Q02779	T138	Sugiyama	MAP3K10 MLK2 MST	RGEEVAVKAARLDPEKDPAVtAEQVCQEARLFGALQHPNII
Q02878	T235	Sugiyama	RPL6 TXREB1	AyFKKKKLRKPRHQEGEIFDtEKEKYEITEQRKIDQKAVDs
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q06830	S152	Sugiyama	PRDX1 PAGA PAGB TDPX2	IIDDKGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEV
Q06830	T143	Sugiyama	PRDX1 PAGA PAGB TDPX2	EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q06830	T156	Sugiyama	PRDX1 PAGA PAGB TDPX2	KGILRQItVNDLPVGRsVDEtLRLVQAFQFtDKHGEVCPAG
Q06830	T166	Sugiyama	PRDX1 PAGA PAGB TDPX2	DLPVGRsVDEtLRLVQAFQFtDKHGEVCPAGWKPGsDtIKP
Q07021	S210	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q07021	S87	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	CGCGCGSLHTDGDKAFVDFLsDEIKEERKIQKHKTLPKMsG
Q08043	T354	Sugiyama	ACTN3	RRLHKPPRIQEKCQLEINFNtLQtKLRLSHRPAFMPSEGKL
Q08043	T357	Sugiyama	ACTN3	HKPPRIQEKCQLEINFNtLQtKLRLSHRPAFMPSEGKLVSD
Q09028	S147	Sugiyama	RBBP4 RBAP48	VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q12874	S76	Sugiyama	SF3A3 SAP61	NLRDLyDDKDGLRKEELNAIsGPNEFAEFyNRLKQIKEFHR
Q13310	T191	Sugiyama	PABPC4 APP1 PABP4	GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13509	S115	Sugiyama	TUBB3 TUBB4	SGAGNNWAKGHytEGAELVDsVLDVVRKECENCDCLQGFQL
Q13509	S75	Sugiyama	TUBB3 TUBB4	SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13509	T107	Sugiyama	TUBB3 TUBB4	PDNFIFGQSGAGNNWAKGHytEGAELVDsVLDVVRKECENC
Q13509	T72	Sugiyama	TUBB3 TUBB4	NEASSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIF
Q13573	S182	Sugiyama	SNW1 SKIIP SKIP	AMPVRAADKLAPAQyIRytPsQQGVAFNsGAKQRVIRMVEM
Q13885	S115	Sugiyama	TUBB2A TUBB2	sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q13885	S75	Sugiyama	TUBB2A TUBB2	AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q13885	T107	Sugiyama	TUBB2A TUBB2	PDNFVFGQsGAGNNWAKGHytEGAELVDsVLDVVRKESESC
Q13885	T72	Sugiyama	TUBB2A TUBB2	NEAAGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152	T1379	Sugiyama	EIF3A EIF3S10 KIAA0139	EKDREsLRRTKNEtDEDGWttVRR_________________
Q14157	T23	Sugiyama	UBAP2L KIAA0144 NICE4	TSVGTNRARGNWEQPQNQNQtQHKQRPQATAEQIRLAQMIS
Q14247	S117	Sugiyama	CTTN EMS1	KsAVGHEyQSKLsKHCsQVDsVRGFGGKFGVQMDRVDQsAV
Q14257	T297	Sugiyama	RCN2 ERC55	LNGDKKLsEEEILENPDLFLtsEAtDyGRQLHDDyFyHDEL
Q14444	S97	Sugiyama	CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105	DYQERMNKGERLNQDQLDAVsKyQEVtNNLEFAKELQRsFM
Q14568	S165	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568	S50	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14568	T171	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	ITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTKVILHLK
Q14677	S166	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q14978	S637	Sugiyama	NOLC1 KIAA0035 NS5ATP13	GEKRAssPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGER
Q14978	S643	Sugiyama	NOLC1 KIAA0035 NS5ATP13	sPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGERANQVLK
Q15080	S67	Sugiyama	NCF4 SH3PXD4	TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15084	S230	Sugiyama	PDIA6 ERP5 P5 TXNDC7	QTKGKVKLAAVDAtVNQVLAsRYGIRGFPtIKIFQKGEsPV
Q15084	T223	Sugiyama	PDIA6 ERP5 P5 TXNDC7	AAsEVKEQTKGKVKLAAVDAtVNQVLAsRYGIRGFPtIKIF
Q15293	S80	Sugiyama	RCN1 RCN	HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q15293	T100	Sugiyama	RCN1 RCN	sKERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNV
Q15293	T101	Sugiyama	RCN1 RCN	KERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNVA
Q15365	S50	Sugiyama	PCBP1	GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK
Q15366	S50	Sugiyama	PCBP2	GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK
Q15459	T124	Sugiyama	SF3A1 SAP114	GKAQEPSAAIPKVMQQQQQTtQQQLPQKVQAQVIQETIVPK
Q16576	S146	Sugiyama	RBBP7 RBAP46	VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3ZCM7	S75	Sugiyama	TUBB8	SGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIFGQC
Q562R1	T250	Sugiyama	ACTBL2	RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q58FF6	T165	Sugiyama	HSP90AB4P	DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7	S370	Sugiyama	HSP90AB3P HSP90BC	KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q58FF7	T169	Sugiyama	HSP90AB3P HSP90BC	DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2	S54	Sugiyama	TUBA3E	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q6PEY2	T73	Sugiyama	TUBA3E	FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
Q6PEY2	T80	Sugiyama	TUBA3E	KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAA
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3	T949	Sugiyama	POTEE A26C1A POTE2	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q6ZMR3	S167	Sugiyama	LDHAL6A LDHL2	AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36	S54	Sugiyama	TUBA1A TUBA3	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	T80	Sugiyama	TUBA1A TUBA3	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q71U36	T82	Sugiyama	TUBA1A TUBA3	VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q71U36	Y83	Sugiyama	TUBA1A TUBA3	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q71UM5	S78	Sugiyama	RPS27L	GCSTVLCQPTGGKARLtEGCsFRRKQH______________
Q7Z4S6	S708	Sugiyama	KIF21A KIAA1708 KIF2	KIRDTQLERDQVLQNLGsVEsysEEKAKKVRSEYEKKLQAM
Q86V81	S8	Sugiyama	ALYREF ALY BEF THOC4	_____________MADKMDMsLDDIIKLNRSQRGGRGGGRG
Q8NBJ5	S616	Sugiyama	COLGALT1 GLT25D1 PSEC0241	EQQALSREAKNsDVLQsPLDsAARDEL______________
Q8NE71	S595	Sugiyama	ABCF1 ABC50	TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP
Q8NFI4	S181	Sugiyama	ST13P5 FAM10A5	LQKPNAAIQDCDRAIEINPDsAQPyKWRGKAHRLLGHWEEA
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8WVJ2	S142	Sugiyama	NUDCD2	LTLERFQKENPGFDFsGAEIsGNytKGGPDFsNLEK_____
Q92630	S449	EPSD\|PSP	DYRK2	DQLACMIELLGMPsQKLLDAsKRAKNFVSSKGYPRYCTVtt
Q92630	T381	EPSD\|PSP	DYRK2	RSGIKVIDFGSSCYEHQRVYtyIQSRFYRAPEVILGARYGM
Q92973	S339	Sugiyama	TNPO1 KPNB2 MIP1 TRN	SDIDIILLKGDVEEDEtIPDsEQDIRPRFHRSRTVAQQHDE
Q96IR7	S360	Sugiyama	HPDL GLOXD1	LIQRQGATGFGQGNIRALWQsVQEQsARSQEA_________
Q99426	T120	Sugiyama	TBCB CG22 CKAP1	DVSRVEKytIsQEAyDQRQDtVRSFLKRsKLGRyNEEERAQ
Q99613	S754	Sugiyama	EIF3C EIF3S8	REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK
Q99832	T300	Sugiyama	CCT7 CCTH NIP7-1	KIHHSGAKVVLSKLPIGDVAtQyFADRDMFCAGRVPEEDLK
Q99832	T351	Sugiyama	CCT7 CCTH NIP7-1	QtSVNALSADVLGRCQVFEEtQIGGERyNFFtGCPKAKTCt
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3	S54	Sugiyama	TUBA1C TUBA6	GQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtV
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	T80	Sugiyama	TUBA1C TUBA6	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BQE3	T82	Sugiyama	TUBA1C TUBA6	VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q9BQE3	Y83	Sugiyama	TUBA1C TUBA6	PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BVA1	S115	Sugiyama	TUBB2B	sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q9BVA1	S75	Sugiyama	TUBB2B	tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BVA1	T107	Sugiyama	TUBB2B	PDNFVFGQsGAGNNWAKGHytEGAELVDsVLDVVRKESESC
Q9BVA1	T72	Sugiyama	TUBB2B	NEAtGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
Q9BXP5	T702	Sugiyama	SRRT ARS2 ASR2	EEEAQKMGRKDPEQEVEKFVtsNtQELGKDKWLCPLsGKKF
Q9BXP5	T705	Sugiyama	SRRT ARS2 ASR2	AQKMGRKDPEQEVEKFVtsNtQELGKDKWLCPLsGKKFKGP
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7	T249	Sugiyama	POTEKP ACTBL3 FKSG30	MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9H788	T142	Sugiyama	SH2D4A PPP1R38 SH2A	TNsLKTKsQyHDLQAPDNQQtKDIWKKVAEKEELEQGsRPA
Q9NQ39	S157	Sugiyama	RPS10P5 RPS10L	TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NYF8	T208	Sugiyama	BCLAF1 BTF KIAA0164	KDtFEHDPsEsIDEFNKssAtsGDIWPGLsAyDNsPRsPHs
Q9UI15	T190	Sugiyama	TAGLN3 NP25	GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9UMX5	T130	Sugiyama	NENF CIR2 SPUF	LTHDTTGLTAKELEALDEVFtKVYKAKYPIVGYTARRILNE
Q9UNX3	T8	Sugiyama	RPL26L1 RPL26P1	_____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UPQ0	S207	Sugiyama	LIMCH1 KIAA1102	RsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVVLRGssD
Q9Y281	T91	Sugiyama	CFL2	FVKLLPLNDCRyALyDAtyEtKESKKEDLVFIFWAPESAPL
Q9Y2B0	S116	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0	S74	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	GsFRINPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGE
Q9Y2B0	T79	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	NPDGsQsVVEVPyARsEAHLtELLEEICDRMKEyGEQIDPs
Q9Y2T7	T143	Sugiyama	YBX2 CSDA3 MSY2	QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y3U8	S91	Sugiyama	RPL36	KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y4L1	S742	Sugiyama	HYOU1 GRP170 HSPH4 ORP150	KLQDLTLRDLEKQEREKAANsLEAFIFEtQDKLyQPEyQEV
Q9Y4L1	T750	Sugiyama	HYOU1 GRP170 HSPH4 ORP150	DLEKQEREKAANsLEAFIFEtQDKLyQPEyQEVsTEEQREE
Q9Y5S9	S56	Sugiyama	RBM8A RBM8 HSPC114 MDS014	KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	4.773959e-15	14.321
Cell Cycle, Mitotic	R-HSA-69278	1.558753e-13	12.807
Axon guidance	R-HSA-422475	2.357195e-09	8.628
Nervous system development	R-HSA-9675108	1.019344e-08	7.992
Signal Transduction	R-HSA-162582	9.663929e-09	8.015
M Phase	R-HSA-68886	1.120165e-08	7.951
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.419971e-08	7.848
Cell Cycle Checkpoints	R-HSA-69620	1.936537e-08	7.713
Apoptotic execution phase	R-HSA-75153	7.869492e-08	7.104
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	7.586236e-08	7.120
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.832292e-07	6.737
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	6.696780e-07	6.174
Signaling by ALK in cancer	R-HSA-9700206	6.696780e-07	6.174
Estrogen-dependent gene expression	R-HSA-9018519	9.804932e-07	6.009
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.597113e-06	5.586
Amplification of signal from the kinetochores	R-HSA-141424	2.597113e-06	5.586
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	3.423949e-06	5.465
Mitotic Prometaphase	R-HSA-68877	3.613039e-06	5.442
Regulation of TP53 Activity	R-HSA-5633007	4.075239e-06	5.390
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.355285e-06	5.271
Chromatin organization	R-HSA-4839726	5.565602e-06	5.254
ESR-mediated signaling	R-HSA-8939211	6.900181e-06	5.161
Mitotic Anaphase	R-HSA-68882	8.586224e-06	5.066
Mitotic Spindle Checkpoint	R-HSA-69618	1.817420e-05	4.741
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.854743e-05	4.732
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.176959e-05	4.662
Chromatin modifying enzymes	R-HSA-3247509	2.640842e-05	4.578
Cellular responses to stress	R-HSA-2262752	2.912426e-05	4.536
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	3.051026e-05	4.516
DNA Double-Strand Break Repair	R-HSA-5693532	3.945003e-05	4.404
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	5.060609e-05	4.296
Mitotic Prophase	R-HSA-68875	5.531519e-05	4.257
Transcriptional Regulation by TP53	R-HSA-3700989	6.471524e-05	4.189
HATs acetylate histones	R-HSA-3214847	7.036633e-05	4.153
Cell-Cell communication	R-HSA-1500931	8.505914e-05	4.070
Separation of Sister Chromatids	R-HSA-2467813	9.802684e-05	4.009
Sema3A PAK dependent Axon repulsion	R-HSA-399954	1.109296e-04	3.955
Cellular responses to stimuli	R-HSA-8953897	1.141833e-04	3.942
EPH-Ephrin signaling	R-HSA-2682334	1.587055e-04	3.799
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.786117e-04	3.748
G2/M DNA damage checkpoint	R-HSA-69473	1.799572e-04	3.745
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.956168e-04	3.709
Semaphorin interactions	R-HSA-373755	2.244188e-04	3.649
L1CAM interactions	R-HSA-373760	2.277027e-04	3.643
Cellular Senescence	R-HSA-2559583	2.618397e-04	3.582
Transcriptional regulation by small RNAs	R-HSA-5578749	2.705463e-04	3.568
Signaling by ERBB2	R-HSA-1227986	2.764357e-04	3.558
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.995002e-04	3.524
Nuclear Envelope Breakdown	R-HSA-2980766	3.404940e-04	3.468
Mitotic G2-G2/M phases	R-HSA-453274	3.842080e-04	3.415
Transport of the SLBP independent Mature mRNA	R-HSA-159227	4.000836e-04	3.398
Signaling by Hippo	R-HSA-2028269	4.119052e-04	3.385
HIV Life Cycle	R-HSA-162587	4.142764e-04	3.383
Apoptosis	R-HSA-109581	4.333721e-04	3.363
DNA Repair	R-HSA-73894	4.680688e-04	3.330
Signaling by SCF-KIT	R-HSA-1433557	4.924996e-04	3.308
Recycling pathway of L1	R-HSA-437239	5.077539e-04	3.294
G2/M Transition	R-HSA-69275	5.200821e-04	3.284
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	5.285748e-04	3.277
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	5.909398e-04	3.228
Regulation of CDH1 Expression and Function	R-HSA-9764265	5.909398e-04	3.228
Selective autophagy	R-HSA-9663891	5.944658e-04	3.226
Signaling by WNT	R-HSA-195721	5.959383e-04	3.225
Ephrin signaling	R-HSA-3928664	6.051668e-04	3.218
Late Phase of HIV Life Cycle	R-HSA-162599	6.340727e-04	3.198
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	6.359132e-04	3.197
G2/M Checkpoints	R-HSA-69481	6.591864e-04	3.181
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	6.899116e-04	3.161
Transcriptional regulation by RUNX1	R-HSA-8878171	6.884814e-04	3.162
Nuclear import of Rev protein	R-HSA-180746	6.910429e-04	3.160
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	6.910429e-04	3.160
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	7.064582e-04	3.151
Nucleosome assembly	R-HSA-774815	7.828377e-04	3.106
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	7.828377e-04	3.106
RNA Polymerase II Pre-transcription Events	R-HSA-674695	8.428911e-04	3.074
SWI/SNF chromatin remodelers	R-HSA-9932451	8.956977e-04	3.048
ATP-dependent chromatin remodelers	R-HSA-9932444	8.956977e-04	3.048
Cellular response to heat stress	R-HSA-3371556	8.683538e-04	3.061
Signaling by VEGF	R-HSA-194138	9.203462e-04	3.036
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	9.367749e-04	3.028
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.057986e-03	2.976
Activation of RAC1	R-HSA-428540	1.095850e-03	2.960
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.087412e-03	2.964
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.045220e-03	2.981
Regulation of MECP2 expression and activity	R-HSA-9022692	1.087412e-03	2.964
Homology Directed Repair	R-HSA-5693538	1.065003e-03	2.973
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.128663e-03	2.947
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.128663e-03	2.947
TCF dependent signaling in response to WNT	R-HSA-201681	1.047959e-03	2.980
Integrin signaling	R-HSA-354192	1.087412e-03	2.964
NoRC negatively regulates rRNA expression	R-HSA-427413	1.045220e-03	2.981
Gene expression (Transcription)	R-HSA-74160	1.035503e-03	2.985
RET signaling	R-HSA-8853659	1.146858e-03	2.940
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.185182e-03	2.926
mRNA Splicing - Major Pathway	R-HSA-72163	1.209249e-03	2.917
Interactions of Rev with host cellular proteins	R-HSA-177243	1.185182e-03	2.926
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.234843e-03	2.908
Metalloprotease DUBs	R-HSA-5689901	1.202659e-03	2.920
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.318473e-03	2.880
Cell junction organization	R-HSA-446728	1.377670e-03	2.861
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.431228e-03	2.844
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.470646e-03	2.832
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.475350e-03	2.831
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.496653e-03	2.825
Programmed Cell Death	R-HSA-5357801	1.515943e-03	2.819
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.566087e-03	2.805
Packaging Of Telomere Ends	R-HSA-171306	1.593169e-03	2.798
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.711334e-03	2.767
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.711334e-03	2.767
Nuclear Receptor transcription pathway	R-HSA-383280	1.643724e-03	2.784
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.643724e-03	2.784
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.601444e-03	2.795
Meiotic synapsis	R-HSA-1221632	1.782956e-03	2.749
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.782956e-03	2.749
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.790318e-03	2.747
Signaling by ROBO receptors	R-HSA-376176	1.812767e-03	2.742
Depurination	R-HSA-73927	1.835580e-03	2.736
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.835580e-03	2.736
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.999691e-03	2.699
mRNA Splicing	R-HSA-72172	2.186118e-03	2.660
Platelet activation, signaling and aggregation	R-HSA-76002	2.254262e-03	2.647
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.264614e-03	2.645
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.293229e-03	2.640
Meiosis	R-HSA-1500620	2.448927e-03	2.611
Sema4D in semaphorin signaling	R-HSA-400685	2.529853e-03	2.597
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	2.755074e-03	2.560
Formation of annular gap junctions	R-HSA-196025	2.755074e-03	2.560
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.693459e-03	2.570
IPs transport between nucleus and cytosol	R-HSA-1855170	2.792888e-03	2.554
HDACs deacetylate histones	R-HSA-3214815	2.587112e-03	2.587
Processing of DNA double-strand break ends	R-HSA-5693607	2.611931e-03	2.583
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.842480e-03	2.546
Aggrephagy	R-HSA-9646399	2.842480e-03	2.546
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.955567e-03	2.529
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	3.027437e-03	2.519
Adherens junctions interactions	R-HSA-418990	3.158854e-03	2.500
Co-stimulation by CD28	R-HSA-389356	3.333864e-03	2.477
Striated Muscle Contraction	R-HSA-390522	3.515504e-03	2.454
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.529359e-03	2.452
Regulation of KIT signaling	R-HSA-1433559	3.666018e-03	2.436
Cleavage of the damaged purine	R-HSA-110331	3.529359e-03	2.452
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	3.515504e-03	2.454
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	3.676771e-03	2.435
ISG15 antiviral mechanism	R-HSA-1169408	4.001593e-03	2.398
Gap junction trafficking and regulation	R-HSA-157858	4.010500e-03	2.397
EPHA-mediated growth cone collapse	R-HSA-3928663	4.239326e-03	2.373
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	4.384580e-03	2.358
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	4.384580e-03	2.358
Gap junction degradation	R-HSA-190873	4.402238e-03	2.356
Inactivation of CDC42 and RAC1	R-HSA-428543	4.402238e-03	2.356
HIV Infection	R-HSA-162906	4.418080e-03	2.355
Signaling by RAS mutants	R-HSA-6802949	5.000420e-03	2.301
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.000420e-03	2.301
Signaling downstream of RAS mutants	R-HSA-9649948	5.000420e-03	2.301
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.000420e-03	2.301
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	5.125801e-03	2.290
RNA Polymerase II Transcription	R-HSA-73857	4.788751e-03	2.320
Diseases of DNA repair	R-HSA-9675135	5.000420e-03	2.301
Cleavage of the damaged pyrimidine	R-HSA-110329	5.180118e-03	2.286
Depyrimidination	R-HSA-73928	5.180118e-03	2.286
Transcription of the HIV genome	R-HSA-167172	5.295332e-03	2.276
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	5.324999e-03	2.274
Deubiquitination	R-HSA-5688426	5.455484e-03	2.263
Signaling by NOTCH	R-HSA-157118	5.561558e-03	2.255
Meiotic recombination	R-HSA-912446	5.706239e-03	2.244
Epigenetic regulation of gene expression	R-HSA-212165	5.898525e-03	2.229
Cell-cell junction organization	R-HSA-421270	5.923787e-03	2.227
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.973668e-03	2.224
Kinesins	R-HSA-983189	6.010301e-03	2.221
Pre-NOTCH Transcription and Translation	R-HSA-1912408	6.355689e-03	2.197
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	6.400369e-03	2.194
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.467617e-03	2.189
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.467617e-03	2.189
Activation of ATR in response to replication stress	R-HSA-176187	6.758719e-03	2.170
FOXO-mediated transcription	R-HSA-9614085	6.913335e-03	2.160
Regulation of CDH1 Gene Transcription	R-HSA-9764560	7.094241e-03	2.149
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	6.569867e-03	2.182
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	7.121268e-03	2.147
Signaling by Nuclear Receptors	R-HSA-9006931	7.338814e-03	2.134
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	7.433421e-03	2.129
Gap junction trafficking	R-HSA-190828	7.472566e-03	2.127
FLT3 Signaling	R-HSA-9607240	7.800107e-03	2.108
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	7.801186e-03	2.108
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	8.085344e-03	2.092
Vpr-mediated nuclear import of PICs	R-HSA-180910	8.085344e-03	2.092
CD28 dependent Vav1 pathway	R-HSA-389359	8.420674e-03	2.075
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.677082e-03	2.062
DNA Double Strand Break Response	R-HSA-5693606	8.785719e-03	2.056
Platelet Aggregation (Plug Formation)	R-HSA-76009	8.891895e-03	2.051
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.023705e-02	1.990
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.019941e-02	1.991
RAF activation	R-HSA-5673000	1.012217e-02	1.995
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.343715e-03	2.029
HIV Transcription Initiation	R-HSA-167161	9.343715e-03	2.029
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.343715e-03	2.029
PI3K/AKT Signaling in Cancer	R-HSA-2219528	9.576609e-03	2.019
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	9.765689e-03	2.010
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	9.761382e-03	2.010
Oxidative Stress Induced Senescence	R-HSA-2559580	9.765689e-03	2.010
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.310183e-03	2.031
Condensation of Prophase Chromosomes	R-HSA-2299718	1.051878e-02	1.978
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.053936e-02	1.977
Gene Silencing by RNA	R-HSA-211000	1.115534e-02	1.953
RNA Polymerase I Transcription	R-HSA-73864	1.125343e-02	1.949
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.153927e-02	1.938
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.155002e-02	1.937
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.187156e-02	1.925
Post NMDA receptor activation events	R-HSA-438064	1.219231e-02	1.914
Regulation of T cell activation by CD28 family	R-HSA-388841	1.220883e-02	1.913
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	1.223491e-02	1.912
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.223913e-02	1.912
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.226150e-02	1.911
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.257902e-02	1.900
RNA Polymerase II Promoter Escape	R-HSA-73776	1.315324e-02	1.881
RNA Polymerase I Promoter Escape	R-HSA-73772	1.351561e-02	1.869
MAPK family signaling cascades	R-HSA-5683057	1.360185e-02	1.866
Signaling by AMER1 mutants	R-HSA-4839748	1.381260e-02	1.860
Signaling by AXIN mutants	R-HSA-4839735	1.381260e-02	1.860
Signaling by GSK3beta mutants	R-HSA-5339716	1.381260e-02	1.860
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.392791e-02	1.856
DNA methylation	R-HSA-5334118	1.594577e-02	1.797
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.594577e-02	1.797
AURKA Activation by TPX2	R-HSA-8854518	1.430235e-02	1.845
Oncogenic MAPK signaling	R-HSA-6802957	1.491635e-02	1.826
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.536264e-02	1.814
Assembly of the ORC complex at the origin of replication	R-HSA-68616	1.536264e-02	1.814
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.430235e-02	1.845
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.447548e-02	1.839
Regulation of CDH11 Expression and Function	R-HSA-9759475	1.594577e-02	1.797
Cell-extracellular matrix interactions	R-HSA-446353	1.546163e-02	1.811
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.546510e-02	1.811
Interleukin-12 signaling	R-HSA-9020591	1.567026e-02	1.805
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.618105e-02	1.791
ALK mutants bind TKIs	R-HSA-9700645	1.618105e-02	1.791
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.627616e-02	1.788
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.627616e-02	1.788
Transport of connexons to the plasma membrane	R-HSA-190872	1.627616e-02	1.788
Membrane Trafficking	R-HSA-199991	1.642247e-02	1.785
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.647098e-02	1.783
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.651373e-02	1.782
Base Excision Repair	R-HSA-73884	1.717120e-02	1.765
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.867369e-02	1.729
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.867369e-02	1.729
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.867369e-02	1.729
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.889270e-02	1.724
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.889270e-02	1.724
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.889270e-02	1.724
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.889270e-02	1.724
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.889270e-02	1.724
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.889270e-02	1.724
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	2.025218e-02	1.694
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.025218e-02	1.694
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.932971e-02	1.714
MAP2K and MAPK activation	R-HSA-5674135	1.935610e-02	1.713
Signaling by RAF1 mutants	R-HSA-9656223	1.935610e-02	1.713
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	1.807957e-02	1.743
Metabolism of non-coding RNA	R-HSA-194441	1.916660e-02	1.717
snRNP Assembly	R-HSA-191859	1.916660e-02	1.717
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.768100e-02	1.752
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.768100e-02	1.752
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.924884e-02	1.716
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.025218e-02	1.694
Activation of the pre-replicative complex	R-HSA-68962	1.932971e-02	1.714
PIP3 activates AKT signaling	R-HSA-1257604	1.963420e-02	1.707
Signaling by LTK	R-HSA-9842663	1.889270e-02	1.724
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.889270e-02	1.724
Autophagy	R-HSA-9612973	1.865859e-02	1.729
Intracellular signaling by second messengers	R-HSA-9006925	1.869473e-02	1.728
Chromosome Maintenance	R-HSA-73886	2.058046e-02	1.687
Notch-HLH transcription pathway	R-HSA-350054	2.058346e-02	1.686
Impaired BRCA2 binding to PALB2	R-HSA-9709603	2.071200e-02	1.684
Interleukin-12 family signaling	R-HSA-447115	2.090444e-02	1.680
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.196126e-02	1.658
Activation of HOX genes during differentiation	R-HSA-5619507	2.211413e-02	1.655
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.211413e-02	1.655
Signaling by NTRKs	R-HSA-166520	2.215891e-02	1.654
MTOR signalling	R-HSA-165159	2.260982e-02	1.646
Signal attenuation	R-HSA-74749	2.283632e-02	1.641
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.283632e-02	1.641
Diseases of programmed cell death	R-HSA-9645723	2.327102e-02	1.633
NRAGE signals death through JNK	R-HSA-193648	2.374730e-02	1.624
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.382381e-02	1.623
Centrosome maturation	R-HSA-380287	2.434299e-02	1.614
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	2.437961e-02	1.613
RNA Polymerase I Promoter Opening	R-HSA-73728	2.437961e-02	1.613
MHC class II antigen presentation	R-HSA-2132295	2.459336e-02	1.609
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.459336e-02	1.609
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	2.983074e-02	1.525
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	2.983074e-02	1.525
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	2.983074e-02	1.525
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	2.983074e-02	1.525
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	2.983074e-02	1.525
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	2.983074e-02	1.525
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	2.983074e-02	1.525
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	2.983074e-02	1.525
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	2.983074e-02	1.525
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	2.983074e-02	1.525
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	2.983074e-02	1.525
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.701835e-02	1.568
SOS-mediated signalling	R-HSA-112412	2.701835e-02	1.568
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.515512e-02	1.599
Co-inhibition by CTLA4	R-HSA-389513	2.595763e-02	1.586
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	2.595763e-02	1.586
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	2.595763e-02	1.586
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	2.595763e-02	1.586
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	2.595763e-02	1.586
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.931755e-02	1.533
Defective pyroptosis	R-HSA-9710421	2.625830e-02	1.581
mRNA 3'-end processing	R-HSA-72187	2.578138e-02	1.589
Regulation of endogenous retroelements	R-HSA-9842860	2.661630e-02	1.575
Formation of definitive endoderm	R-HSA-9823730	2.595763e-02	1.586
Interleukin-6 signaling	R-HSA-1059683	2.515512e-02	1.599
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.578138e-02	1.589
Generic Transcription Pathway	R-HSA-212436	2.833558e-02	1.548
Macroautophagy	R-HSA-1632852	2.633668e-02	1.579
tRNA processing in the nucleus	R-HSA-6784531	2.812019e-02	1.551
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	2.661630e-02	1.575
EPHB-mediated forward signaling	R-HSA-3928662	3.032702e-02	1.518
Netrin-1 signaling	R-HSA-373752	3.032702e-02	1.518
RMTs methylate histone arginines	R-HSA-3214858	3.032702e-02	1.518
Post-transcriptional silencing by small RNAs	R-HSA-426496	3.045927e-02	1.516
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.045927e-02	1.516
G1/S-Specific Transcription	R-HSA-69205	3.046821e-02	1.516
Signaling by APC mutants	R-HSA-4839744	3.111953e-02	1.507
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	3.111953e-02	1.507
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	3.111953e-02	1.507
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	3.111953e-02	1.507
PECAM1 interactions	R-HSA-210990	3.111953e-02	1.507
G1/S Transition	R-HSA-69206	3.173017e-02	1.499
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	3.207877e-02	1.494
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.268913e-02	1.486
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.268913e-02	1.486
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.268913e-02	1.486
CRMPs in Sema3A signaling	R-HSA-399956	3.270686e-02	1.485
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.282358e-02	1.484
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.282358e-02	1.484
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	3.284411e-02	1.484
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.284411e-02	1.484
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	3.284411e-02	1.484
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.327840e-02	1.478
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.484045e-02	1.458
Glycolysis	R-HSA-70171	3.510005e-02	1.455
SIRT1 negatively regulates rRNA expression	R-HSA-427359	3.551904e-02	1.450
TGFBR3 expression	R-HSA-9839394	3.712303e-02	1.430
Influenza Viral RNA Transcription and Replication	R-HSA-168273	3.768750e-02	1.424
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	3.787538e-02	1.422
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.815425e-02	1.418
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.913420e-02	1.407
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	4.423495e-02	1.354
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	4.423495e-02	1.354
Diseases of Telomere Maintenance	R-HSA-9673013	4.423495e-02	1.354
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	4.423495e-02	1.354
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	4.423495e-02	1.354
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	4.423495e-02	1.354
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	4.423495e-02	1.354
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	4.423495e-02	1.354
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	4.423495e-02	1.354
Negative feedback regulation of MAPK pathway	R-HSA-5674499	4.579007e-02	1.339
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	4.579007e-02	1.339
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.115000e-02	1.386
Adenylate cyclase inhibitory pathway	R-HSA-170670	4.163673e-02	1.381
Beta-catenin phosphorylation cascade	R-HSA-196299	4.163673e-02	1.381
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	4.717440e-02	1.326
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.126470e-02	1.384
DAP12 signaling	R-HSA-2424491	4.126470e-02	1.384
Dual Incision in GG-NER	R-HSA-5696400	4.463687e-02	1.350
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.529271e-02	1.344
Signaling by EGFR	R-HSA-177929	4.270410e-02	1.370
RNA Polymerase II Transcription Termination	R-HSA-73856	4.373163e-02	1.359
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.990408e-02	1.399
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	4.756746e-02	1.323
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	4.756746e-02	1.323
Transcriptional Regulation by E2F6	R-HSA-8953750	4.736176e-02	1.325
Downregulation of ERBB2 signaling	R-HSA-8863795	4.126470e-02	1.384
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	4.756746e-02	1.323
DCC mediated attractive signaling	R-HSA-418885	4.163673e-02	1.381
HDR through Homologous Recombination (HRR)	R-HSA-5685942	4.953794e-02	1.305
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.736176e-02	1.325
Pre-NOTCH Expression and Processing	R-HSA-1912422	4.903161e-02	1.310
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.115000e-02	1.386
Circadian clock	R-HSA-9909396	3.996269e-02	1.398
Activation of BH3-only proteins	R-HSA-114452	4.126470e-02	1.384
Metabolism of RNA	R-HSA-8953854	4.058151e-02	1.392
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.343455e-02	1.362
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.270410e-02	1.370
Signaling by KIT in disease	R-HSA-9669938	4.717440e-02	1.326
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	4.834834e-02	1.316
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	3.982180e-02	1.400
Signaling by FGFR4	R-HSA-5654743	4.954445e-02	1.305
Regulation of signaling by CBL	R-HSA-912631	4.987085e-02	1.302
Reproduction	R-HSA-1474165	5.063967e-02	1.296
Signalling to ERKs	R-HSA-187687	5.161884e-02	1.287
Oncogene Induced Senescence	R-HSA-2559585	5.161884e-02	1.287
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	5.170755e-02	1.286
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	5.170755e-02	1.286
MET activates PTPN11	R-HSA-8865999	5.170755e-02	1.286
WNT mediated activation of DVL	R-HSA-201688	5.172736e-02	1.286
HCMV Early Events	R-HSA-9609690	5.292771e-02	1.276
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.301089e-02	1.276
SHC-related events triggered by IGF1R	R-HSA-2428933	5.301089e-02	1.276
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.301089e-02	1.276
Formation of Incision Complex in GG-NER	R-HSA-5696395	5.420428e-02	1.266
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	5.492929e-02	1.260
G alpha (12/13) signalling events	R-HSA-416482	5.542780e-02	1.256
G0 and Early G1	R-HSA-1538133	5.621365e-02	1.250
Signaling by WNT in cancer	R-HSA-4791275	5.621365e-02	1.250
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	5.624036e-02	1.250
PRC2 methylates histones and DNA	R-HSA-212300	5.930679e-02	1.227
GPVI-mediated activation cascade	R-HSA-114604	5.930679e-02	1.227
Regulation of TP53 Degradation	R-HSA-6804757	5.930679e-02	1.227
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	5.970113e-02	1.224
Nephrin family interactions	R-HSA-373753	6.020842e-02	1.220
IGF1R signaling cascade	R-HSA-2428924	6.036987e-02	1.219
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.073848e-02	1.217
Signaling by FGFR3	R-HSA-5654741	6.349514e-02	1.197
Processing of Intronless Pre-mRNAs	R-HSA-77595	6.388040e-02	1.195
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.388040e-02	1.195
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.388040e-02	1.195
Signaling by TGF-beta Receptor Complex	R-HSA-170834	6.482063e-02	1.188
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	6.488493e-02	1.188
Ub-specific processing proteases	R-HSA-5689880	6.574691e-02	1.182
Signaling by NOTCH3	R-HSA-9012852	6.577877e-02	1.182
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	6.636273e-02	1.178
CD209 (DC-SIGN) signaling	R-HSA-5621575	6.636273e-02	1.178
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	6.640839e-02	1.178
Signaling by FGFR2	R-HSA-5654738	6.668766e-02	1.176
PKR-mediated signaling	R-HSA-9833482	6.668766e-02	1.176
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	6.674727e-02	1.176
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.677358e-02	1.175
Inositol phosphate metabolism	R-HSA-1483249	6.762001e-02	1.170
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.772065e-02	1.169
Regulation of CDH11 function	R-HSA-9762292	6.777783e-02	1.169
Receptor Mediated Mitophagy	R-HSA-8934903	6.777783e-02	1.169
EGFR Transactivation by Gastrin	R-HSA-2179392	6.777783e-02	1.169
Defective Base Excision Repair Associated with OGG1	R-HSA-9656249	8.946565e-02	1.048
Oligomerization of connexins into connexons	R-HSA-190704	8.946565e-02	1.048
Transport of connexins along the secretory pathway	R-HSA-190827	8.946565e-02	1.048
Transport of glycerol from adipocytes to the liver by Aquaporins	R-HSA-432030	8.946565e-02	1.048
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	8.946565e-02	1.048
Manipulation of host energy metabolism	R-HSA-9636667	8.946565e-02	1.048
Regulation of gap junction activity	R-HSA-191650	7.938968e-02	1.100
Inhibition of TSC complex formation by PKB	R-HSA-165181	7.938968e-02	1.100
MECP2 regulates transcription factors	R-HSA-9022707	8.704906e-02	1.060
Activation of PUMA and translocation to mitochondria	R-HSA-139915	8.704906e-02	1.060
Cation-coupled Chloride cotransporters	R-HSA-426117	8.704906e-02	1.060
Disinhibition of SNARE formation	R-HSA-114516	8.704906e-02	1.060
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	8.704906e-02	1.060
Activated NTRK3 signals through RAS	R-HSA-9034864	8.627764e-02	1.064
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	8.627764e-02	1.064
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.236611e-02	1.084
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	7.726159e-02	1.112
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	7.179818e-02	1.144
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	7.179818e-02	1.144
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	7.756112e-02	1.110
Downstream signaling of activated FGFR3	R-HSA-5654708	7.096557e-02	1.149
Signaling by ERBB2 KD Mutants	R-HSA-9664565	7.096557e-02	1.149
Signaling by ERBB2 in Cancer	R-HSA-1227990	8.173322e-02	1.088
Downstream signaling of activated FGFR4	R-HSA-5654716	8.173322e-02	1.088
Formation of RNA Pol II elongation complex	R-HSA-112382	8.060625e-02	1.094
RNA Polymerase II Transcription Elongation	R-HSA-75955	8.934997e-02	1.049
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.107979e-02	1.091
Transcriptional Regulation by MECP2	R-HSA-8986944	7.784087e-02	1.109
MITF-M-dependent gene expression	R-HSA-9856651	7.715448e-02	1.113
Regulation of CDH1 Function	R-HSA-9764561	8.099104e-02	1.092
Resolution of D-Loop Structures	R-HSA-5693537	7.438042e-02	1.129
Signaling by FGFR1	R-HSA-5654736	7.312324e-02	1.136
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	8.099104e-02	1.092
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	8.984373e-02	1.047
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.312324e-02	1.136
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	8.897570e-02	1.051
DNA Replication Pre-Initiation	R-HSA-69002	7.953871e-02	1.099
p75 NTR receptor-mediated signalling	R-HSA-193704	7.596279e-02	1.119
Mitophagy	R-HSA-5205647	8.471195e-02	1.072
UCH proteinases	R-HSA-5689603	7.327474e-02	1.135
Gap junction assembly	R-HSA-190861	8.471195e-02	1.072
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	8.236611e-02	1.084
Extra-nuclear estrogen signaling	R-HSA-9009391	8.834373e-02	1.054
Myogenesis	R-HSA-525793	8.984373e-02	1.047
Developmental Biology	R-HSA-1266738	7.859137e-02	1.105
Breakdown of the nuclear lamina	R-HSA-352238	8.946565e-02	1.048
RNA Polymerase I Transcription Initiation	R-HSA-73762	7.865045e-02	1.104
Signaling by NTRK1 (TRKA)	R-HSA-187037	8.507961e-02	1.070
Regulation of localization of FOXO transcription factors	R-HSA-9614399	8.627764e-02	1.064
Organelle biogenesis and maintenance	R-HSA-1852241	8.950460e-02	1.048
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	8.974732e-02	1.047
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	8.915183e-02	1.050
Signaling by PTK6	R-HSA-8848021	8.915183e-02	1.050
AKT-mediated inactivation of FOXO1A	R-HSA-211163	7.938968e-02	1.100
Signal regulatory protein family interactions	R-HSA-391160	8.236611e-02	1.084
SARS-CoV-2-host interactions	R-HSA-9705683	7.413733e-02	1.130
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.085284e-02	1.042
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	8.869241e-02	1.052
Influenza Infection	R-HSA-168255	6.837798e-02	1.165
Chaperone Mediated Autophagy	R-HSA-9613829	9.215470e-02	1.035
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	9.588473e-02	1.018
Clathrin-mediated endocytosis	R-HSA-8856828	9.648349e-02	1.016
Telomere Maintenance	R-HSA-157579	9.665381e-02	1.015
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.819925e-02	1.008
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.819925e-02	1.008
mTORC1-mediated signalling	R-HSA-166208	9.876825e-02	1.005
Spry regulation of FGF signaling	R-HSA-1295596	9.983762e-02	1.001
Erythropoietin activates RAS	R-HSA-9027284	9.983762e-02	1.001
Activation of BAD and translocation to mitochondria	R-HSA-111447	9.983762e-02	1.001
IRF3-mediated induction of type I IFN	R-HSA-3270619	9.983762e-02	1.001
Signaling by TGFB family members	R-HSA-9006936	1.013073e-01	0.994
Interaction between L1 and Ankyrins	R-HSA-445095	1.032073e-01	0.986
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.032073e-01	0.986
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.032073e-01	0.986
Cellular response to chemical stress	R-HSA-9711123	1.035047e-01	0.985
MITF-M-regulated melanocyte development	R-HSA-9730414	1.040910e-01	0.983
Protein ubiquitination	R-HSA-8852135	1.043137e-01	0.982
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.043137e-01	0.982
MAPK1/MAPK3 signaling	R-HSA-5684996	1.046234e-01	0.980
Activated NTRK2 signals through RAS	R-HSA-9026519	1.071371e-01	0.970
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.076733e-01	0.968
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.077904e-01	0.967
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.077904e-01	0.967
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.077904e-01	0.967
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.077904e-01	0.967
Regulation of PTEN gene transcription	R-HSA-8943724	1.077904e-01	0.967
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.077904e-01	0.967
STING mediated induction of host immune responses	R-HSA-1834941	1.085352e-01	0.964
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.085705e-01	0.964
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.088595e-01	0.963
Adipogenesis	R-HSA-9843745	1.093797e-01	0.961
Mitochondrial biogenesis	R-HSA-1592230	1.097505e-01	0.960
Glucose metabolism	R-HSA-70326	1.097505e-01	0.960
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	1.113439e-01	0.953
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	1.121474e-01	0.950
IRS activation	R-HSA-74713	1.121474e-01	0.950
Co-inhibition by BTLA	R-HSA-9927353	1.121474e-01	0.950
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	1.126221e-01	0.948
Signaling by MRAS-complex mutants	R-HSA-9660537	1.126221e-01	0.948
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.126221e-01	0.948
Signaling by Interleukins	R-HSA-449147	1.129454e-01	0.947
Signaling by NOTCH1	R-HSA-1980143	1.131027e-01	0.947
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.136794e-01	0.944
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.141259e-01	0.943
Golgi-to-ER retrograde transport	R-HSA-8856688	1.160871e-01	0.935
Viral Messenger RNA Synthesis	R-HSA-168325	1.177947e-01	0.929
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.197046e-01	0.922
G-protein beta:gamma signalling	R-HSA-397795	1.197046e-01	0.922
Signaling by TGFBR3	R-HSA-9839373	1.207509e-01	0.918
Host Interactions of HIV factors	R-HSA-162909	1.215103e-01	0.915
RAF/MAP kinase cascade	R-HSA-5673001	1.237523e-01	0.907
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.263567e-01	0.898
Signal transduction by L1	R-HSA-445144	1.263567e-01	0.898
Cytokine Signaling in Immune system	R-HSA-1280215	1.271348e-01	0.896
Heme signaling	R-HSA-9707616	1.283309e-01	0.892
Pervasive developmental disorders	R-HSA-9005895	1.302135e-01	0.885
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.302135e-01	0.885
Disorders of Nervous System Development	R-HSA-9697154	1.302135e-01	0.885
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.302135e-01	0.885
MET activates RAS signaling	R-HSA-8851805	1.302135e-01	0.885
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.302135e-01	0.885
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.306912e-01	0.884
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.306912e-01	0.884
Neurodegenerative Diseases	R-HSA-8863678	1.306912e-01	0.884
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.306912e-01	0.884
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.352936e-01	0.869
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.391374e-01	0.857
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.400525e-01	0.854
Disorders of Developmental Biology	R-HSA-9675151	1.400525e-01	0.854
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	1.400525e-01	0.854
Transcriptional regulation of testis differentiation	R-HSA-9690406	1.400525e-01	0.854
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.400525e-01	0.854
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.528478e-01	0.816
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.528478e-01	0.816
Defective OGG1 Substrate Binding	R-HSA-9656255	1.528478e-01	0.816
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.528478e-01	0.816
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.528478e-01	0.816
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	1.528478e-01	0.816
Defective OGG1 Localization	R-HSA-9657050	1.528478e-01	0.816
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.528478e-01	0.816
Regulation of TP53 Expression	R-HSA-6804754	1.432003e-01	0.844
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.432003e-01	0.844
Regulation of cortical dendrite branching	R-HSA-8985801	1.432003e-01	0.844
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	1.432003e-01	0.844
MET interacts with TNS proteins	R-HSA-8875513	2.017845e-01	0.695
Axonal growth stimulation	R-HSA-209563	2.017845e-01	0.695
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	1.491009e-01	0.827
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.491009e-01	0.827
CDC6 association with the ORC:origin complex	R-HSA-68689	1.491009e-01	0.827
Phosphorylation of Emi1	R-HSA-176417	1.491009e-01	0.827
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.410874e-01	0.851
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.893193e-01	0.723
STAT5 Activation	R-HSA-9645135	1.893193e-01	0.723
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	1.893193e-01	0.723
MET activates RAP1 and RAC1	R-HSA-8875555	1.720594e-01	0.764
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	1.553203e-01	0.809
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.553203e-01	0.809
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.051162e-01	0.688
RHOBTB3 ATPase cycle	R-HSA-9706019	2.051162e-01	0.688
Prolactin receptor signaling	R-HSA-1170546	1.822372e-01	0.739
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	1.625806e-01	0.789
Signalling to RAS	R-HSA-167044	1.455530e-01	0.837
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.455530e-01	0.837
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	2.107197e-01	0.676
SHC1 events in EGFR signaling	R-HSA-180336	2.107197e-01	0.676
FRS-mediated FGFR3 signaling	R-HSA-5654706	1.660400e-01	0.780
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.495819e-01	0.825
Signaling by EGFR in Cancer	R-HSA-1643713	1.672391e-01	0.777
FRS-mediated FGFR4 signaling	R-HSA-5654712	1.877184e-01	0.726
FGFR2 alternative splicing	R-HSA-6803529	1.877184e-01	0.726
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.670148e-01	0.777
RNA Polymerase I Transcription Termination	R-HSA-73863	1.870878e-01	0.728
Interleukin receptor SHC signaling	R-HSA-912526	2.104758e-01	0.677
Downstream signaling of activated FGFR1	R-HSA-5654687	1.658593e-01	0.780
Downstream signaling of activated FGFR2	R-HSA-5654696	1.658593e-01	0.780
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	1.853512e-01	0.732
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.078795e-01	0.682
Insulin receptor signalling cascade	R-HSA-74751	1.509713e-01	0.821
IRS-related events triggered by IGF1R	R-HSA-2428928	1.798001e-01	0.745
IRS-mediated signalling	R-HSA-112399	1.984947e-01	0.702
Post-translational protein phosphorylation	R-HSA-8957275	1.486567e-01	0.828
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	1.705607e-01	0.768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.771298e-01	0.752
Cap-dependent Translation Initiation	R-HSA-72737	1.943587e-01	0.711
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.053930e-01	0.687
Eukaryotic Translation Initiation	R-HSA-72613	1.943587e-01	0.711
Signaling by FGFR	R-HSA-190236	1.486567e-01	0.828
Apoptosis induced DNA fragmentation	R-HSA-140342	1.720594e-01	0.764
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.865394e-01	0.729
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.672391e-01	0.777
Polo-like kinase mediated events	R-HSA-156711	1.865394e-01	0.729
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.865394e-01	0.729
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	1.672391e-01	0.777
Platelet degranulation	R-HSA-114608	2.036217e-01	0.691
Resolution of Abasic Sites (AP sites)	R-HSA-73933	1.800360e-01	0.745
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	2.078795e-01	0.682
Formation of intermediate mesoderm	R-HSA-9761174	1.720594e-01	0.764
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.792915e-01	0.746
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.593808e-01	0.798
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.891504e-01	0.723
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.660400e-01	0.780
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.660400e-01	0.780
Nuclear RNA decay	R-HSA-9930044	2.045282e-01	0.689
PTEN Regulation	R-HSA-6807070	1.788124e-01	0.748
PKMTs methylate histone lysines	R-HSA-3214841	1.800360e-01	0.745
Co-inhibition by PD-1	R-HSA-389948	1.512743e-01	0.820
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	2.107197e-01	0.676
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	2.107197e-01	0.676
Generation of second messenger molecules	R-HSA-202433	1.640793e-01	0.785
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.715261e-01	0.766
Signaling by FGFR1 in disease	R-HSA-5655302	1.966881e-01	0.706
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.410874e-01	0.851
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.506556e-01	0.822
Eukaryotic Translation Elongation	R-HSA-156842	1.882701e-01	0.725
Downstream signal transduction	R-HSA-186763	1.670148e-01	0.777
Nef and signal transduction	R-HSA-164944	1.893193e-01	0.723
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.107197e-01	0.676
RUNX2 regulates bone development	R-HSA-8941326	1.829169e-01	0.738
Regulation of NFE2L2 gene expression	R-HSA-9818749	1.893193e-01	0.723
FLT3 signaling in disease	R-HSA-9682385	1.829169e-01	0.738
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	1.893193e-01	0.723
Signaling by PDGFR in disease	R-HSA-9671555	1.660400e-01	0.780
Signaling by FGFR4 in disease	R-HSA-5655291	1.822372e-01	0.739
Syndecan interactions	R-HSA-3000170	2.104758e-01	0.677
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.107197e-01	0.676
Tie2 Signaling	R-HSA-210993	1.865394e-01	0.729
Signaling by NTRK3 (TRKC)	R-HSA-9034015	1.660400e-01	0.780
Regulation of NPAS4 gene expression	R-HSA-9768759	1.625806e-01	0.789
CASP5-mediated substrate cleavage	R-HSA-9960525	2.017845e-01	0.695
Viral Infection Pathways	R-HSA-9824446	1.812812e-01	0.742
Sensory processing of sound	R-HSA-9659379	2.043324e-01	0.690
Signaling by Leptin	R-HSA-2586552	1.720594e-01	0.764
CASP4-mediated substrate cleavage	R-HSA-9960519	2.017845e-01	0.695
Growth hormone receptor signaling	R-HSA-982772	2.104758e-01	0.677
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.840199e-01	0.735
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.491009e-01	0.827
MAPK6/MAPK4 signaling	R-HSA-5687128	2.112729e-01	0.675
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.115725e-01	0.675
The NLRP3 inflammasome	R-HSA-844456	2.117691e-01	0.674
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.117691e-01	0.674
Rap1 signalling	R-HSA-392517	2.117691e-01	0.674
Defective OGG1 Substrate Processing	R-HSA-9656256	2.823405e-01	0.549
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	2.823405e-01	0.549
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.823405e-01	0.549
Defective MOGS causes CDG-2b	R-HSA-4793954	2.823405e-01	0.549
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.823405e-01	0.549
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	2.823405e-01	0.549
TICAM1 deficiency - HSE	R-HSA-5602566	2.823405e-01	0.549
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	2.624817e-01	0.581
NADE modulates death signalling	R-HSA-205025	2.624817e-01	0.581
HCN channels	R-HSA-1296061	2.624817e-01	0.581
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	2.624817e-01	0.581
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	2.624817e-01	0.581
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.624817e-01	0.581
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.624817e-01	0.581
GRB7 events in ERBB2 signaling	R-HSA-1306955	2.624817e-01	0.581
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	2.624817e-01	0.581
Defective LFNG causes SCDO3	R-HSA-5083630	2.624817e-01	0.581
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	2.624817e-01	0.581
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.624817e-01	0.581
Signaling by MAP2K mutants	R-HSA-9652169	2.624817e-01	0.581
Interactions of Tat with host cellular proteins	R-HSA-176034	3.920457e-01	0.407
Mitochondrial transcription initiation	R-HSA-163282	3.920457e-01	0.407
NFG and proNGF binds to p75NTR	R-HSA-205017	3.920457e-01	0.407
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	R-HSA-73930	3.920457e-01	0.407
Defective MMADHC causes MMAHCD	R-HSA-3359473	3.920457e-01	0.407
Defective SLC12A3 causes Gitelman syndrome (GS)	R-HSA-5619087	3.920457e-01	0.407
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	3.920457e-01	0.407
XAV939 stabilizes AXIN	R-HSA-5545619	3.920457e-01	0.407
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.920457e-01	0.407
TRAF3 deficiency - HSE	R-HSA-5602571	3.920457e-01	0.407
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.920457e-01	0.407
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.920457e-01	0.407
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	3.920457e-01	0.407
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.920457e-01	0.407
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	2.318878e-01	0.635
RUNX3 regulates WNT signaling	R-HSA-8951430	2.318878e-01	0.635
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.318878e-01	0.635
Netrin mediated repulsion signals	R-HSA-418886	2.318878e-01	0.635
Cohesin Loading onto Chromatin	R-HSA-2470946	2.318878e-01	0.635
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	3.232782e-01	0.490
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	3.232782e-01	0.490
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	3.232782e-01	0.490
Activation of AKT2	R-HSA-165158	3.232782e-01	0.490
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.232782e-01	0.490
NTRK2 activates RAC1	R-HSA-9032759	3.232782e-01	0.490
G2 Phase	R-HSA-68911	3.232782e-01	0.490
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	3.232782e-01	0.490
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.759500e-01	0.559
Activated NTRK2 signals through FYN	R-HSA-9032500	2.759500e-01	0.559
Type I hemidesmosome assembly	R-HSA-446107	2.759500e-01	0.559
Downregulation of ERBB4 signaling	R-HSA-1253288	2.759500e-01	0.559
Activation of RAS in B cells	R-HSA-1169092	2.759500e-01	0.559
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	2.398207e-01	0.620
GRB2 events in EGFR signaling	R-HSA-179812	2.757374e-01	0.560
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	3.207341e-01	0.494
Lipophagy	R-HSA-9613354	3.207341e-01	0.494
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	3.207341e-01	0.494
Regulated proteolysis of p75NTR	R-HSA-193692	3.207341e-01	0.494
MAPK1 (ERK2) activation	R-HSA-112411	3.207341e-01	0.494
Noncanonical activation of NOTCH3	R-HSA-9017802	3.827260e-01	0.417
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.827260e-01	0.417
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	3.827260e-01	0.417
PKB-mediated events	R-HSA-109703	3.827260e-01	0.417
PDE3B signalling	R-HSA-165160	3.827260e-01	0.417
Acetylcholine regulates insulin secretion	R-HSA-399997	2.713353e-01	0.566
GRB2 events in ERBB2 signaling	R-HSA-1963640	2.713353e-01	0.566
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.713353e-01	0.566
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.713353e-01	0.566
Formation of axial mesoderm	R-HSA-9796292	3.124462e-01	0.505
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	3.124462e-01	0.505
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	3.124462e-01	0.505
Deadenylation of mRNA	R-HSA-429947	2.341900e-01	0.630
SHC-mediated cascade:FGFR3	R-HSA-5654704	2.653436e-01	0.576
MyD88 deficiency (TLR2/4)	R-HSA-5602498	2.653436e-01	0.576
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.655653e-01	0.437
MAPK3 (ERK1) activation	R-HSA-110056	3.655653e-01	0.437
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	3.655653e-01	0.437
2-LTR circle formation	R-HSA-164843	3.655653e-01	0.437
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	3.655653e-01	0.437
Folding of actin by CCT/TriC	R-HSA-390450	3.655653e-01	0.437
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.295233e-01	0.639
Late endosomal microautophagy	R-HSA-9615710	2.295233e-01	0.639
PI3K events in ERBB2 signaling	R-HSA-1963642	3.029354e-01	0.519
FRS-mediated FGFR1 signaling	R-HSA-5654693	2.587310e-01	0.587
Long-term potentiation	R-HSA-9620244	2.587310e-01	0.587
SHC-mediated cascade:FGFR4	R-HSA-5654719	2.933236e-01	0.533
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.933236e-01	0.533
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	2.933236e-01	0.533
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	3.495524e-01	0.456
Removal of the Flap Intermediate	R-HSA-69166	3.495524e-01	0.456
PTK6 promotes HIF1A stabilization	R-HSA-8857538	4.398173e-01	0.357
Signaling by LTK in cancer	R-HSA-9842640	4.398173e-01	0.357
G2/M DNA replication checkpoint	R-HSA-69478	4.398173e-01	0.357
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	4.398173e-01	0.357
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.384287e-01	0.623
GAB1 signalosome	R-HSA-180292	3.350478e-01	0.475
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.350478e-01	0.475
EGFR downregulation	R-HSA-182971	2.749730e-01	0.561
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	4.098703e-01	0.387
HIV Transcription Elongation	R-HSA-167169	2.581812e-01	0.588
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.581812e-01	0.588
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.581812e-01	0.588
Processive synthesis on the C-strand of the telomere	R-HSA-174414	3.097522e-01	0.509
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	3.097522e-01	0.509
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	3.097522e-01	0.509
Diseases of mitotic cell cycle	R-HSA-9675126	2.985709e-01	0.525
p38MAPK events	R-HSA-171007	3.866937e-01	0.413
ERBB2 Regulates Cell Motility	R-HSA-6785631	3.866937e-01	0.413
Germ layer formation at gastrulation	R-HSA-9754189	3.674235e-01	0.435
PI-3K cascade:FGFR3	R-HSA-5654710	3.674235e-01	0.435
PI3K Cascade	R-HSA-109704	2.607055e-01	0.584
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	3.507502e-01	0.455
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	3.507502e-01	0.455
Pyroptosis	R-HSA-5620971	3.359580e-01	0.474
FRS-mediated FGFR2 signaling	R-HSA-5654700	3.359580e-01	0.474
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.359580e-01	0.474
HIV elongation arrest and recovery	R-HSA-167287	3.359580e-01	0.474
Formation of the Early Elongation Complex	R-HSA-113418	3.359580e-01	0.474
Pausing and recovery of HIV elongation	R-HSA-167290	3.359580e-01	0.474
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	2.304805e-01	0.637
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.226086e-01	0.491
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.303574e-01	0.638
MET promotes cell motility	R-HSA-8875878	3.330110e-01	0.478
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.469785e-01	0.460
Signaling by Erythropoietin	R-HSA-9006335	3.624458e-01	0.441
SHC-mediated cascade:FGFR1	R-HSA-5654688	3.798403e-01	0.420
Regulation of PD-L1(CD274) translation	R-HSA-9909620	3.998287e-01	0.398
PI-3K cascade:FGFR4	R-HSA-5654720	3.998287e-01	0.398
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	4.235448e-01	0.373
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	4.235448e-01	0.373
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	4.235448e-01	0.373
Dual incision in TC-NER	R-HSA-6782135	3.053257e-01	0.515
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.053257e-01	0.515
Negative regulation of FGFR2 signaling	R-HSA-5654727	3.715743e-01	0.430
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.890838e-01	0.410
Translation initiation complex formation	R-HSA-72649	3.357697e-01	0.474
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	3.075058e-01	0.512
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.320474e-01	0.364
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	4.157453e-01	0.381
Formation of a pool of free 40S subunits	R-HSA-72689	3.121211e-01	0.506
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	3.748650e-01	0.426
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	4.210319e-01	0.376
mRNA Splicing - Minor Pathway	R-HSA-72165	4.069121e-01	0.390
Signaling by NOTCH4	R-HSA-9013694	3.872805e-01	0.412
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.018422e-01	0.396
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	3.831212e-01	0.417
Viral mRNA Translation	R-HSA-192823	4.310846e-01	0.365
Nucleotide Excision Repair	R-HSA-5696398	2.345498e-01	0.630
RNA Polymerase III Transcription	R-HSA-74158	4.210319e-01	0.376
Cyclin E associated events during G1/S transition	R-HSA-69202	4.201048e-01	0.377
Ribosome-associated quality control	R-HSA-9948299	4.253664e-01	0.371
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.524589e-01	0.453
Negative regulation of FGFR1 signaling	R-HSA-5654726	3.226086e-01	0.491
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	3.121211e-01	0.506
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.304805e-01	0.637
Prolonged ERK activation events	R-HSA-169893	2.405079e-01	0.619
CD28 dependent PI3K/Akt signaling	R-HSA-389357	3.097522e-01	0.509
Activation of SMO	R-HSA-5635838	4.235448e-01	0.373
p75NTR regulates axonogenesis	R-HSA-193697	3.207341e-01	0.494
Lysosome Vesicle Biogenesis	R-HSA-432720	2.881723e-01	0.540
HSF1-dependent transactivation	R-HSA-3371571	2.789502e-01	0.554
Developmental Lineages of the Mammary Gland	R-HSA-9924644	3.524589e-01	0.453
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	3.352692e-01	0.475
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	2.318878e-01	0.635
Processive synthesis on the lagging strand	R-HSA-69183	3.866937e-01	0.413
ERK/MAPK targets	R-HSA-198753	4.320474e-01	0.364
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.717424e-01	0.566
Golgi Associated Vesicle Biogenesis	R-HSA-432722	4.317543e-01	0.365
DNA Damage Bypass	R-HSA-73893	3.489488e-01	0.457
Frs2-mediated activation	R-HSA-170968	3.124462e-01	0.505
Signal amplification	R-HSA-392518	2.451203e-01	0.611
trans-Golgi Network Vesicle Budding	R-HSA-199992	2.603226e-01	0.584
S Phase	R-HSA-69242	3.433784e-01	0.464
Axonal growth inhibition (RHOA activation)	R-HSA-193634	2.759500e-01	0.559
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.341900e-01	0.630
Class I peroxisomal membrane protein import	R-HSA-9603798	4.235448e-01	0.373
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.693165e-01	0.570
Assembly of the pre-replicative complex	R-HSA-68867	3.524825e-01	0.453
Signaling by CSF3 (G-CSF)	R-HSA-9674555	3.624458e-01	0.441
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.405079e-01	0.619
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.827260e-01	0.417
Formation of lateral plate mesoderm	R-HSA-9758920	3.827260e-01	0.417
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	3.124462e-01	0.505
PI3K/AKT activation	R-HSA-198203	3.655653e-01	0.437
Deadenylation-dependent mRNA decay	R-HSA-429914	2.289314e-01	0.640
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	3.330110e-01	0.478
Peptide chain elongation	R-HSA-156902	2.646241e-01	0.577
Ovarian tumor domain proteases	R-HSA-5689896	3.104116e-01	0.508
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	3.469785e-01	0.460
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.098703e-01	0.387
Early Phase of HIV Life Cycle	R-HSA-162594	4.320474e-01	0.364
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	3.232782e-01	0.490
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.759500e-01	0.559
Sodium/Proton exchangers	R-HSA-425986	2.759500e-01	0.559
CREB phosphorylation	R-HSA-199920	4.398173e-01	0.357
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	4.398173e-01	0.357
NADPH regeneration	R-HSA-389542	4.398173e-01	0.357
Synaptic adhesion-like molecules	R-HSA-8849932	3.350478e-01	0.475
Evasion by RSV of host interferon responses	R-HSA-9833109	2.749730e-01	0.561
Telomere C-strand synthesis initiation	R-HSA-174430	3.866937e-01	0.413
Transcriptional regulation by RUNX3	R-HSA-8878159	3.411473e-01	0.467
Cardiogenesis	R-HSA-9733709	3.226086e-01	0.491
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.962923e-01	0.402
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.379417e-01	0.359
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.839641e-01	0.547
Hedgehog 'off' state	R-HSA-5610787	2.293080e-01	0.640
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	2.341900e-01	0.630
Hedgehog 'on' state	R-HSA-5632684	4.383833e-01	0.358
ER to Golgi Anterograde Transport	R-HSA-199977	2.670581e-01	0.573
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.624458e-01	0.441
Signaling by MET	R-HSA-6806834	2.973631e-01	0.527
DNA Replication	R-HSA-69306	2.702457e-01	0.568
Cilium Assembly	R-HSA-5617833	2.510327e-01	0.600
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	2.244764e-01	0.649
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	3.232782e-01	0.490
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	2.398207e-01	0.620
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	2.405079e-01	0.619
Killing mechanisms	R-HSA-9664420	2.405079e-01	0.619
Calcineurin activates NFAT	R-HSA-2025928	3.207341e-01	0.494
Post-chaperonin tubulin folding pathway	R-HSA-389977	2.380973e-01	0.623
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	3.655653e-01	0.437
Beta-catenin independent WNT signaling	R-HSA-3858494	3.994828e-01	0.399
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.323801e-01	0.364
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	2.778360e-01	0.556
Signaling by Hedgehog	R-HSA-5358351	2.219435e-01	0.654
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	2.713353e-01	0.566
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.207341e-01	0.494
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.379417e-01	0.359
Interleukin-6 family signaling	R-HSA-6783589	2.341900e-01	0.630
G alpha (z) signalling events	R-HSA-418597	3.552310e-01	0.449
HCMV Infection	R-HSA-9609646	2.821355e-01	0.550
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	3.524589e-01	0.453
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.671820e-01	0.435
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	3.827260e-01	0.417
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.218529e-01	0.492
Eukaryotic Translation Termination	R-HSA-72764	3.985839e-01	0.399
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.671820e-01	0.435
Negative regulation of MAPK pathway	R-HSA-5675221	2.991632e-01	0.524
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.081352e-01	0.389
Toll-like Receptor Cascades	R-HSA-168898	3.783839e-01	0.422
COPI-mediated anterograde transport	R-HSA-6807878	3.265483e-01	0.486
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.081352e-01	0.389
G1/S DNA Damage Checkpoints	R-HSA-69615	3.984634e-01	0.400
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	3.232782e-01	0.490
Effects of PIP2 hydrolysis	R-HSA-114508	3.469785e-01	0.460
Transcriptional Regulation by VENTX	R-HSA-8853884	2.784492e-01	0.555
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	2.521807e-01	0.598
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.182755e-01	0.497
DAP12 interactions	R-HSA-2172127	2.503593e-01	0.601
Amyloid fiber formation	R-HSA-977225	4.075198e-01	0.390
Formation of editosomes by ADAR proteins	R-HSA-77042	2.823405e-01	0.549
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.624817e-01	0.581
Dopamine receptors	R-HSA-390651	2.624817e-01	0.581
FLT3 signaling through SRC family kinases	R-HSA-9706374	2.624817e-01	0.581
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.920457e-01	0.407
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	3.920457e-01	0.407
Nectin/Necl trans heterodimerization	R-HSA-420597	3.232782e-01	0.490
Reelin signalling pathway	R-HSA-8866376	3.232782e-01	0.490
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	3.232782e-01	0.490
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	3.232782e-01	0.490
SMAC (DIABLO) binds to IAPs	R-HSA-111463	3.232782e-01	0.490
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.350478e-01	0.475
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	3.350478e-01	0.475
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	3.866937e-01	0.413
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	2.214166e-01	0.655
VEGFR2 mediated cell proliferation	R-HSA-5218921	4.089563e-01	0.388
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.798559e-01	0.553
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	3.224864e-01	0.491
G-protein mediated events	R-HSA-112040	2.688278e-01	0.571
Muscle contraction	R-HSA-397014	2.521807e-01	0.598
Inflammasomes	R-HSA-622312	3.359580e-01	0.474
Death Receptor Signaling	R-HSA-73887	4.159378e-01	0.381
SARS-CoV-1-host interactions	R-HSA-9692914	2.466083e-01	0.608
Transcriptional regulation by RUNX2	R-HSA-8878166	2.921982e-01	0.534
GP1b-IX-V activation signalling	R-HSA-430116	3.207341e-01	0.494
Other semaphorin interactions	R-HSA-416700	3.866937e-01	0.413
Signaling by ALK	R-HSA-201556	2.384287e-01	0.623
Suppression of apoptosis	R-HSA-9635465	4.098703e-01	0.387
Selenocysteine synthesis	R-HSA-2408557	4.008113e-01	0.397
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	4.144413e-01	0.383
Adrenoceptors	R-HSA-390696	2.759500e-01	0.559
HDMs demethylate histones	R-HSA-3214842	4.089563e-01	0.388
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.287179e-01	0.483
Interleukin-2 family signaling	R-HSA-451927	2.581812e-01	0.588
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	2.398207e-01	0.620
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.827260e-01	0.417
GPER1 signaling	R-HSA-9634597	3.285909e-01	0.483
Apoptotic factor-mediated response	R-HSA-111471	3.350478e-01	0.475
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	3.402215e-01	0.468
Formation of the nephric duct	R-HSA-9830364	2.587310e-01	0.587
Integration of provirus	R-HSA-162592	2.398207e-01	0.620
Interleukin-15 signaling	R-HSA-8983432	2.757374e-01	0.560
Zygotic genome activation (ZGA)	R-HSA-9819196	2.653436e-01	0.576
Calmodulin induced events	R-HSA-111933	4.210319e-01	0.376
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	3.827260e-01	0.417
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.226086e-01	0.491
CaM pathway	R-HSA-111997	4.210319e-01	0.376
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	3.124462e-01	0.505
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.827260e-01	0.417
Interleukin-7 signaling	R-HSA-1266695	4.089563e-01	0.388
Diseases of Base Excision Repair	R-HSA-9605308	3.827260e-01	0.417
Specification of primordial germ cells	R-HSA-9827857	3.029354e-01	0.519
NrCAM interactions	R-HSA-447038	3.232782e-01	0.490
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	3.207341e-01	0.494
Release of apoptotic factors from the mitochondria	R-HSA-111457	3.827260e-01	0.417
Maturation of spike protein	R-HSA-9683686	3.655653e-01	0.437
SARS-CoV Infections	R-HSA-9679506	3.734098e-01	0.428
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	3.827260e-01	0.417
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	3.827260e-01	0.417
SARS-CoV-2 Infection	R-HSA-9694516	3.289822e-01	0.483
XBP1(S) activates chaperone genes	R-HSA-381038	4.099329e-01	0.387
IRE1alpha activates chaperones	R-HSA-381070	4.121187e-01	0.385
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	3.798403e-01	0.420
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	4.098703e-01	0.387
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	3.715743e-01	0.430
Interleukin-37 signaling	R-HSA-9008059	2.519219e-01	0.599
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.423101e-01	0.354
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	4.452486e-01	0.351
MyD88 cascade initiated on plasma membrane	R-HSA-975871	4.452486e-01	0.351
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	4.452486e-01	0.351
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	4.462522e-01	0.350
GABA B receptor activation	R-HSA-977444	4.484105e-01	0.348
Activation of GABAB receptors	R-HSA-991365	4.484105e-01	0.348
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	4.531752e-01	0.344
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	4.531752e-01	0.344
Condensation of Prometaphase Chromosomes	R-HSA-2514853	4.531752e-01	0.344
Reduction of cytosolic Ca++ levels	R-HSA-418359	4.531752e-01	0.344
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	4.531752e-01	0.344
Cytochrome c-mediated apoptotic response	R-HSA-111461	4.531752e-01	0.344
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	4.540802e-01	0.343
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.566389e-01	0.340
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	4.598199e-01	0.337
SHC1 events in ERBB4 signaling	R-HSA-1250347	4.598199e-01	0.337
Vesicle-mediated transport	R-HSA-5653656	4.601628e-01	0.337
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	4.638837e-01	0.334
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	4.638837e-01	0.334
Mitochondrial calcium ion transport	R-HSA-8949215	4.638837e-01	0.334
SARS-CoV-1 Infection	R-HSA-9678108	4.658164e-01	0.332
SHC-mediated cascade:FGFR2	R-HSA-5654699	4.666517e-01	0.331
Cristae formation	R-HSA-8949613	4.666517e-01	0.331
Signaling by FGFR3 in disease	R-HSA-5655332	4.666517e-01	0.331
Interferon Signaling	R-HSA-913531	4.681272e-01	0.330
FGFR1 mutant receptor activation	R-HSA-1839124	4.686656e-01	0.329
TBC/RABGAPs	R-HSA-8854214	4.713999e-01	0.327
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	4.713999e-01	0.327
MAP kinase activation	R-HSA-450294	4.738149e-01	0.324
Ca2+ pathway	R-HSA-4086398	4.748339e-01	0.323
Protein-protein interactions at synapses	R-HSA-6794362	4.755751e-01	0.323
Defective UGT1A4 causes hyperbilirubinemia	R-HSA-5579016	4.849860e-01	0.314
Signalling to ERK5	R-HSA-198765	4.849860e-01	0.314
Potassium transport channels	R-HSA-1296067	4.849860e-01	0.314
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	R-HSA-5619104	4.849860e-01	0.314
Defective visual phototransduction due to STRA6 loss of function	R-HSA-9918449	4.849860e-01	0.314
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)	R-HSA-5619049	4.849860e-01	0.314
Signaling by RAS GAP mutants	R-HSA-9753510	4.849860e-01	0.314
Transcription from mitochondrial promoters	R-HSA-75944	4.849860e-01	0.314
mRNA Editing: A to I Conversion	R-HSA-75064	4.849860e-01	0.314
C6 deamination of adenosine	R-HSA-75102	4.849860e-01	0.314
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	4.849860e-01	0.314
Signaling by ERBB4	R-HSA-1236394	4.929322e-01	0.307
Signaling by PDGF	R-HSA-186797	4.934159e-01	0.307
Ribosomal scanning and start codon recognition	R-HSA-72702	4.936667e-01	0.307
Ion homeostasis	R-HSA-5578775	4.936667e-01	0.307
MET activates PI3K/AKT signaling	R-HSA-8851907	4.938836e-01	0.306
TRIF-mediated programmed cell death	R-HSA-2562578	4.938836e-01	0.306
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	4.938836e-01	0.306
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.938836e-01	0.306
PTK6 Expression	R-HSA-8849473	4.938836e-01	0.306
Phase 3 - rapid repolarisation	R-HSA-5576890	4.938836e-01	0.306
Regulation of PTEN localization	R-HSA-8948747	4.938836e-01	0.306
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	4.938836e-01	0.306
Uptake and function of diphtheria toxin	R-HSA-5336415	4.938836e-01	0.306
G1 Phase	R-HSA-69236	4.941841e-01	0.306
Cyclin D associated events in G1	R-HSA-69231	4.941841e-01	0.306
Telomere Extension By Telomerase	R-HSA-171319	4.949543e-01	0.305
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	4.949543e-01	0.305
p75NTR recruits signalling complexes	R-HSA-209543	4.951004e-01	0.305
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	4.951004e-01	0.305
RUNX3 regulates p14-ARF	R-HSA-8951936	4.951004e-01	0.305
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	4.951004e-01	0.305
Scavenging by Class F Receptors	R-HSA-3000484	4.951004e-01	0.305
Regulation of IFNG signaling	R-HSA-877312	4.951004e-01	0.305
RUNX3 regulates NOTCH signaling	R-HSA-8941856	4.951004e-01	0.305
Repression of WNT target genes	R-HSA-4641265	4.951004e-01	0.305
OAS antiviral response	R-HSA-8983711	4.951004e-01	0.305
PI-3K cascade:FGFR1	R-HSA-5654689	4.951632e-01	0.305
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	4.951632e-01	0.305
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.951632e-01	0.305
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.952732e-01	0.305
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	4.952732e-01	0.305
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	4.952732e-01	0.305
Uptake and function of anthrax toxins	R-HSA-5210891	4.952732e-01	0.305
Hemostasis	R-HSA-109582	4.955715e-01	0.305
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	5.066183e-01	0.295
Potential therapeutics for SARS	R-HSA-9679191	5.153914e-01	0.288
DAG and IP3 signaling	R-HSA-1489509	5.166969e-01	0.287
Unfolded Protein Response (UPR)	R-HSA-381119	5.167007e-01	0.287
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	5.183682e-01	0.285
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	5.183682e-01	0.285
Attenuation phase	R-HSA-3371568	5.183682e-01	0.285
Diseases of Immune System	R-HSA-5260271	5.183682e-01	0.285
Diseases associated with the TLR signaling cascade	R-HSA-5602358	5.183682e-01	0.285
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	5.203405e-01	0.284
Regulation of TLR by endogenous ligand	R-HSA-5686938	5.203405e-01	0.284
mRNA Capping	R-HSA-72086	5.227308e-01	0.282
Termination of translesion DNA synthesis	R-HSA-5656169	5.227308e-01	0.282
Platelet calcium homeostasis	R-HSA-418360	5.227308e-01	0.282
Signaling by Insulin receptor	R-HSA-74752	5.246990e-01	0.280
Regulation of PTEN mRNA translation	R-HSA-8943723	5.257330e-01	0.279
Free fatty acids regulate insulin secretion	R-HSA-400451	5.257330e-01	0.279
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.257330e-01	0.279
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	5.296986e-01	0.276
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	5.296986e-01	0.276
Mismatch Repair	R-HSA-5358508	5.296986e-01	0.276
Platelet sensitization by LDL	R-HSA-432142	5.296986e-01	0.276
Adenylate cyclase activating pathway	R-HSA-170660	5.353518e-01	0.271
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.353518e-01	0.271
Membrane binding and targetting of GAG proteins	R-HSA-174490	5.353518e-01	0.271
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.353518e-01	0.271
Neurexins and neuroligins	R-HSA-6794361	5.362972e-01	0.271
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.362972e-01	0.271
Opioid Signalling	R-HSA-111885	5.376876e-01	0.269
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	5.388766e-01	0.269
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	5.418882e-01	0.266
Maturation of spike protein	R-HSA-9694548	5.418882e-01	0.266
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	5.442463e-01	0.264
RSK activation	R-HSA-444257	5.445156e-01	0.264
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	5.445156e-01	0.264
FGFR1b ligand binding and activation	R-HSA-190370	5.445156e-01	0.264
MET receptor recycling	R-HSA-8875656	5.445156e-01	0.264
Activated NTRK2 signals through PI3K	R-HSA-9028335	5.445156e-01	0.264
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	5.445156e-01	0.264
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	5.445156e-01	0.264
rRNA processing in the nucleus and cytosol	R-HSA-8868773	5.461348e-01	0.263
Regulation of mitotic cell cycle	R-HSA-453276	5.485460e-01	0.261
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.485460e-01	0.261
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	5.492611e-01	0.260
TP53 Regulates Metabolic Genes	R-HSA-5628897	5.493872e-01	0.260
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.493872e-01	0.260
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	5.498765e-01	0.260
RNA Polymerase III Transcription Initiation	R-HSA-76046	5.498765e-01	0.260
MyD88-independent TLR4 cascade	R-HSA-166166	5.509972e-01	0.259
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	5.509972e-01	0.259
Extension of Telomeres	R-HSA-180786	5.538358e-01	0.257
TRAF6 mediated NF-kB activation	R-HSA-933542	5.554620e-01	0.255
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	5.606671e-01	0.251
E2F mediated regulation of DNA replication	R-HSA-113510	5.629278e-01	0.250
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	5.629278e-01	0.250
Translesion Synthesis by POLH	R-HSA-110320	5.629278e-01	0.250
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	5.629278e-01	0.250
Specification of the neural plate border	R-HSA-9834899	5.629278e-01	0.250
PCP/CE pathway	R-HSA-4086400	5.636845e-01	0.249
Defective MMACHC causes MAHCC	R-HSA-3359474	5.637228e-01	0.249
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	5.637228e-01	0.249
Defective GCLC causes HAGGSD	R-HSA-5578999	5.637228e-01	0.249
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	5.637228e-01	0.249
Invadopodia formation	R-HSA-8941237	5.637228e-01	0.249
Classical Kir channels	R-HSA-1296053	5.637228e-01	0.249
IRAK4 deficiency (TLR5)	R-HSA-5603037	5.637228e-01	0.249
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	5.637228e-01	0.249
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	5.637228e-01	0.249
Activation of BIM and translocation to mitochondria	R-HSA-111446	5.637228e-01	0.249
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	5.637228e-01	0.249
Intracellular oxygen transport	R-HSA-8981607	5.637228e-01	0.249
The NLRP1 inflammasome	R-HSA-844455	5.637228e-01	0.249
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	5.649420e-01	0.248
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	5.649420e-01	0.248
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	5.675932e-01	0.246
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	5.698848e-01	0.244
HSF1 activation	R-HSA-3371511	5.700454e-01	0.244
Retrograde neurotrophin signalling	R-HSA-177504	5.737124e-01	0.241
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	5.737124e-01	0.241
NRIF signals cell death from the nucleus	R-HSA-205043	5.737124e-01	0.241
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	5.737124e-01	0.241
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	5.737124e-01	0.241
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.737124e-01	0.241
Neutrophil degranulation	R-HSA-6798695	5.739210e-01	0.241
Cargo concentration in the ER	R-HSA-5694530	5.763003e-01	0.239
Gastrulation	R-HSA-9758941	5.790097e-01	0.237
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	5.808095e-01	0.236
NGF-stimulated transcription	R-HSA-9031628	5.820174e-01	0.235
Intraflagellar transport	R-HSA-5620924	5.820174e-01	0.235
PI-3K cascade:FGFR2	R-HSA-5654695	5.842404e-01	0.233
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.842404e-01	0.233
Tight junction interactions	R-HSA-420029	5.842404e-01	0.233
Ca-dependent events	R-HSA-111996	5.874716e-01	0.231
Rab regulation of trafficking	R-HSA-9007101	5.914909e-01	0.228
ARMS-mediated activation	R-HSA-170984	5.914998e-01	0.228
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	5.914998e-01	0.228
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	5.914998e-01	0.228
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	5.914998e-01	0.228
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	5.914998e-01	0.228
Regulation of CDH11 gene transcription	R-HSA-9762293	5.914998e-01	0.228
Cellular response to mitochondrial stress	R-HSA-9840373	5.914998e-01	0.228
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	5.914998e-01	0.228
Respiratory syncytial virus genome replication	R-HSA-9834752	5.914998e-01	0.228
PLC beta mediated events	R-HSA-112043	5.923910e-01	0.227
Degradation of DVL	R-HSA-4641258	5.939740e-01	0.226
Negative regulation of MET activity	R-HSA-6807004	5.948281e-01	0.226
Common Pathway of Fibrin Clot Formation	R-HSA-140875	5.948281e-01	0.226
HCMV Late Events	R-HSA-9610379	6.012951e-01	0.221
Adaptive Immune System	R-HSA-1280218	6.027511e-01	0.220
Degradation of CDH1	R-HSA-9766229	6.028818e-01	0.220
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.028818e-01	0.220
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.028818e-01	0.220
Regulated Necrosis	R-HSA-5218859	6.061038e-01	0.217
Cellular responses to mechanical stimuli	R-HSA-9855142	6.080280e-01	0.216
p75NTR signals via NF-kB	R-HSA-193639	6.100320e-01	0.215
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	6.100320e-01	0.215
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	6.100320e-01	0.215
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.100320e-01	0.215
Formation of the anterior neural plate	R-HSA-9823739	6.100320e-01	0.215
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.110762e-01	0.214
Stimuli-sensing channels	R-HSA-2672351	6.110762e-01	0.214
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	6.110912e-01	0.214
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	6.110912e-01	0.214
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	6.119787e-01	0.213
TRP channels	R-HSA-3295583	6.119787e-01	0.213
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	6.167412e-01	0.210
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.172068e-01	0.210
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	6.203035e-01	0.207
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.251393e-01	0.204
Lagging Strand Synthesis	R-HSA-69186	6.252994e-01	0.204
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	6.252994e-01	0.204
Response of endothelial cells to shear stress	R-HSA-9860931	6.287264e-01	0.202
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.293653e-01	0.201
Nucleotide catabolism defects	R-HSA-9735786	6.304258e-01	0.200
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	6.304258e-01	0.200
Defective CP causes aceruloplasminemia (ACERULOP)	R-HSA-5619060	6.304258e-01	0.200
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	R-HSA-2978092	6.304258e-01	0.200
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	6.304258e-01	0.200
Activation of NOXA and translocation to mitochondria	R-HSA-111448	6.304258e-01	0.200
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	6.304258e-01	0.200
Binding and entry of HIV virion	R-HSA-173107	6.347681e-01	0.197
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	6.347681e-01	0.197
DNA replication initiation	R-HSA-68952	6.347681e-01	0.197
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	6.347681e-01	0.197
Interleukin-27 signaling	R-HSA-9020956	6.347681e-01	0.197
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	6.347681e-01	0.197
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	6.347681e-01	0.197
Pexophagy	R-HSA-9664873	6.347681e-01	0.197
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	6.347681e-01	0.197
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	6.386066e-01	0.195
TCR signaling	R-HSA-202403	6.389628e-01	0.195
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	6.396957e-01	0.194
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	6.409788e-01	0.193
Interleukin-17 signaling	R-HSA-448424	6.409788e-01	0.193
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	6.442181e-01	0.191
Phosphorylation of the APC/C	R-HSA-176412	6.442181e-01	0.191
Phase 4 - resting membrane potential	R-HSA-5576886	6.442181e-01	0.191
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	6.442181e-01	0.191
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	6.442181e-01	0.191
Negative regulation of FLT3	R-HSA-9706369	6.442181e-01	0.191
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.442181e-01	0.191
Ion transport by P-type ATPases	R-HSA-936837	6.471872e-01	0.189
Fanconi Anemia Pathway	R-HSA-6783310	6.514378e-01	0.186
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.542714e-01	0.184
Assembly Of The HIV Virion	R-HSA-175474	6.542714e-01	0.184
Negative regulation of NOTCH4 signaling	R-HSA-9604323	6.614012e-01	0.180
Orc1 removal from chromatin	R-HSA-68949	6.621848e-01	0.179
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.621848e-01	0.179
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	6.714275e-01	0.173
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	6.743584e-01	0.171
Ionotropic activity of kainate receptors	R-HSA-451306	6.743584e-01	0.171
vRNP Assembly	R-HSA-192905	6.743584e-01	0.171
SARS-CoV-2 modulates autophagy	R-HSA-9754560	6.743584e-01	0.171
Synthesis of PI	R-HSA-1483226	6.743584e-01	0.171
Bicarbonate transporters	R-HSA-425381	6.743584e-01	0.171
Prostanoid ligand receptors	R-HSA-391908	6.743584e-01	0.171
Interleukin-2 signaling	R-HSA-9020558	6.743584e-01	0.171
ChREBP activates metabolic gene expression	R-HSA-163765	6.743584e-01	0.171
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	6.762265e-01	0.170
G beta:gamma signalling through CDC42	R-HSA-8964616	6.762265e-01	0.170
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.788763e-01	0.168
Regulation of PTEN stability and activity	R-HSA-8948751	6.807567e-01	0.167
Smooth Muscle Contraction	R-HSA-445355	6.807567e-01	0.167
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.817000e-01	0.166
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	6.817000e-01	0.166
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.817000e-01	0.166
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.817000e-01	0.166
RAF-independent MAPK1/3 activation	R-HSA-112409	6.817000e-01	0.166
Regulation of IFNA/IFNB signaling	R-HSA-912694	6.817000e-01	0.166
NOSIP mediated eNOS trafficking	R-HSA-203754	6.869337e-01	0.163
FLT3 signaling by CBL mutants	R-HSA-9706377	6.869337e-01	0.163
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	6.869337e-01	0.163
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	6.869337e-01	0.163
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	6.869337e-01	0.163
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	6.869337e-01	0.163
Muscarinic acetylcholine receptors	R-HSA-390648	6.869337e-01	0.163
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	6.869337e-01	0.163
Switching of origins to a post-replicative state	R-HSA-69052	6.900724e-01	0.161
Degradation of CRY and PER proteins	R-HSA-9932298	7.023459e-01	0.153
Degradation of GLI1 by the proteasome	R-HSA-5610780	7.023459e-01	0.153
Signaling by FGFR in disease	R-HSA-1226099	7.055108e-01	0.151
Regulation of FZD by ubiquitination	R-HSA-4641263	7.060531e-01	0.151
Elevation of cytosolic Ca2+ levels	R-HSA-139853	7.060531e-01	0.151
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	7.060531e-01	0.151
Replication of the SARS-CoV-2 genome	R-HSA-9694686	7.060531e-01	0.151
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	7.075642e-01	0.150
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.075642e-01	0.150
Gluconeogenesis	R-HSA-70263	7.092515e-01	0.149
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.103838e-01	0.149
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	7.103838e-01	0.149
ERKs are inactivated	R-HSA-202670	7.103838e-01	0.149
Sensing of DNA Double Strand Breaks	R-HSA-5693548	7.103838e-01	0.149
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.103838e-01	0.149
NF-kB is activated and signals survival	R-HSA-209560	7.103838e-01	0.149
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.159809e-01	0.145
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	7.162307e-01	0.145
Chaperonin-mediated protein folding	R-HSA-390466	7.199394e-01	0.143
NCAM signaling for neurite out-growth	R-HSA-375165	7.225077e-01	0.141
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	7.270541e-01	0.138
RSV-host interactions	R-HSA-9833110	7.270854e-01	0.138
Thromboxane signalling through TP receptor	R-HSA-428930	7.318630e-01	0.136
Trafficking of AMPA receptors	R-HSA-399719	7.331997e-01	0.135
Budding and maturation of HIV virion	R-HSA-162588	7.331997e-01	0.135
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	7.337260e-01	0.134
RNA Polymerase III Transcription Termination	R-HSA-73980	7.337260e-01	0.134
PKA activation in glucagon signalling	R-HSA-164378	7.337260e-01	0.134
PKA activation	R-HSA-163615	7.337260e-01	0.134
Plus-strand DNA synthesis	R-HSA-164525	7.348044e-01	0.134
Nef Mediated CD8 Down-regulation	R-HSA-182218	7.348044e-01	0.134
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	7.348044e-01	0.134
PTK6 Regulates Cell Cycle	R-HSA-8849470	7.348044e-01	0.134
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	7.348044e-01	0.134
Signaling by RNF43 mutants	R-HSA-5340588	7.348044e-01	0.134
CLEC7A/inflammasome pathway	R-HSA-5660668	7.348044e-01	0.134
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	7.348044e-01	0.134
Ceramide signalling	R-HSA-193681	7.348044e-01	0.134
Proton/oligopeptide cotransporters	R-HSA-427975	7.348044e-01	0.134
Sensory perception of salty taste	R-HSA-9730628	7.348044e-01	0.134
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	7.348044e-01	0.134
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	7.348044e-01	0.134
Signalling to p38 via RIT and RIN	R-HSA-187706	7.348044e-01	0.134
Sodium-coupled phosphate cotransporters	R-HSA-427652	7.348044e-01	0.134
Release of Hh-Np from the secreting cell	R-HSA-5362798	7.348044e-01	0.134
TRAF6 mediated IRF7 activation	R-HSA-933541	7.361217e-01	0.133
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.381257e-01	0.132
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	7.430088e-01	0.129
Polymerase switching	R-HSA-69091	7.430088e-01	0.129
Leading Strand Synthesis	R-HSA-69109	7.430088e-01	0.129
IRAK1 recruits IKK complex	R-HSA-937039	7.430088e-01	0.129
Role of second messengers in netrin-1 signaling	R-HSA-418890	7.430088e-01	0.129
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	7.430088e-01	0.129
Interleukin-35 Signalling	R-HSA-8984722	7.430088e-01	0.129
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	7.430088e-01	0.129
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	7.430088e-01	0.129
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	7.430088e-01	0.129
Regulation of RAS by GAPs	R-HSA-5658442	7.441051e-01	0.128
Cellular response to starvation	R-HSA-9711097	7.489687e-01	0.126
FCGR3A-mediated phagocytosis	R-HSA-9664422	7.520242e-01	0.124
Parasite infection	R-HSA-9664407	7.520242e-01	0.124
Leishmania phagocytosis	R-HSA-9664417	7.520242e-01	0.124
DNA strand elongation	R-HSA-69190	7.537911e-01	0.123
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.592992e-01	0.120
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	7.592992e-01	0.120
Other interleukin signaling	R-HSA-449836	7.592992e-01	0.120
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.592992e-01	0.120
Transmission across Chemical Synapses	R-HSA-112315	7.619551e-01	0.118
Synthesis of DNA	R-HSA-69239	7.625436e-01	0.118
Cellular response to hypoxia	R-HSA-1234174	7.675576e-01	0.115
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	7.724307e-01	0.112
FGFR1c ligand binding and activation	R-HSA-190373	7.724307e-01	0.112
Reversible hydration of carbon dioxide	R-HSA-1475029	7.724307e-01	0.112
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	7.724307e-01	0.112
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	7.728695e-01	0.112
Regulation of necroptotic cell death	R-HSA-5675482	7.731705e-01	0.112
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	7.731705e-01	0.112
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	7.739712e-01	0.111
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	7.739712e-01	0.111
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.739712e-01	0.111
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	7.753574e-01	0.110
Erythropoietin activates STAT5	R-HSA-9027283	7.753574e-01	0.110
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	7.753574e-01	0.110
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	R-HSA-3656244	7.753574e-01	0.110
Uncoating of the HIV Virion	R-HSA-162585	7.753574e-01	0.110
Defective CHST3 causes SEDCJD	R-HSA-3595172	7.753574e-01	0.110
Defective CHST6 causes MCDC1	R-HSA-3656225	7.753574e-01	0.110
Defective ST3GAL3 causes MCT12 and EIEE15	R-HSA-3656243	7.753574e-01	0.110
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	7.753574e-01	0.110
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	7.753574e-01	0.110
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	7.753574e-01	0.110
Intracellular metabolism of fatty acids regulates insulin secretion	R-HSA-434313	7.753574e-01	0.110
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	7.753574e-01	0.110
Leukotriene receptors	R-HSA-391906	7.753574e-01	0.110
VLDL assembly	R-HSA-8866423	7.753574e-01	0.110
CREB3 factors activate genes	R-HSA-8874211	7.753574e-01	0.110
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	7.758420e-01	0.110
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.758420e-01	0.110
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.758420e-01	0.110
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.759445e-01	0.110
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.792611e-01	0.108
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	7.792611e-01	0.108
VxPx cargo-targeting to cilium	R-HSA-5620916	7.828461e-01	0.106
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.828461e-01	0.106
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.828461e-01	0.106
Signaling by NODAL	R-HSA-1181150	7.828461e-01	0.106
Eicosanoid ligand-binding receptors	R-HSA-391903	7.828461e-01	0.106
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.897297e-01	0.103
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.897297e-01	0.103
Nuclear signaling by ERBB4	R-HSA-1251985	7.897454e-01	0.103
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	7.907398e-01	0.102
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.907398e-01	0.102
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	7.913599e-01	0.102
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.913599e-01	0.102
GABA receptor activation	R-HSA-977443	7.924303e-01	0.101
Protein folding	R-HSA-391251	7.945581e-01	0.100
Maturation of hRSV A proteins	R-HSA-9828806	7.955935e-01	0.099
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	7.986220e-01	0.098
cGMP effects	R-HSA-418457	7.988663e-01	0.098
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	7.988663e-01	0.098
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	7.988663e-01	0.098
Non-canonical inflammasome activation	R-HSA-9686114	7.988663e-01	0.098
Ion channel transport	R-HSA-983712	8.023522e-01	0.096
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	8.044549e-01	0.094
TNFR1-induced proapoptotic signaling	R-HSA-5357786	8.044549e-01	0.094
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.044549e-01	0.094
PKA-mediated phosphorylation of CREB	R-HSA-111931	8.044549e-01	0.094
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.047961e-01	0.094
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.057260e-01	0.094
Signaling by NOTCH2	R-HSA-1980145	8.083885e-01	0.092
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	8.090586e-01	0.092
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	8.097112e-01	0.092
IFNG signaling activates MAPKs	R-HSA-9732724	8.097112e-01	0.092
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	8.097112e-01	0.092
Defective CHSY1 causes TPBS	R-HSA-3595177	8.097112e-01	0.092
Recycling of eIF2:GDP	R-HSA-72731	8.097112e-01	0.092
NOSTRIN mediated eNOS trafficking	R-HSA-203641	8.097112e-01	0.092
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	8.097112e-01	0.092
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	8.097112e-01	0.092
VLDL clearance	R-HSA-8964046	8.097112e-01	0.092
LDL remodeling	R-HSA-8964041	8.097112e-01	0.092
Synthesis of PIPs in the nucleus	R-HSA-8847453	8.097112e-01	0.092
SLC-mediated transport of oligopeptides	R-HSA-9959399	8.097112e-01	0.092
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	8.097112e-01	0.092
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)	R-HSA-9026762	8.097112e-01	0.092
CHL1 interactions	R-HSA-447041	8.097112e-01	0.092
Activated NTRK2 signals through CDK5	R-HSA-9032845	8.097112e-01	0.092
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.139176e-01	0.089
Mitochondrial protein import	R-HSA-1268020	8.183724e-01	0.087
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.205921e-01	0.086
Cytoprotection by HMOX1	R-HSA-9707564	8.221601e-01	0.085
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	8.225406e-01	0.085
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.225406e-01	0.085
Translesion synthesis by REV1	R-HSA-110312	8.225406e-01	0.085
Lysosphingolipid and LPA receptors	R-HSA-419408	8.225406e-01	0.085
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	8.225406e-01	0.085
Protein methylation	R-HSA-8876725	8.225406e-01	0.085
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	8.242238e-01	0.084
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	8.242238e-01	0.084
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	8.242913e-01	0.084
PERK regulates gene expression	R-HSA-381042	8.242913e-01	0.084
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.260671e-01	0.083
COPII-mediated vesicle transport	R-HSA-204005	8.306860e-01	0.081
DARPP-32 events	R-HSA-180024	8.308716e-01	0.080
Regulation of gene expression in beta cells	R-HSA-210745	8.308716e-01	0.080
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	8.346131e-01	0.079
PPARA activates gene expression	R-HSA-1989781	8.351920e-01	0.078
Reverse Transcription of HIV RNA	R-HSA-162589	8.388130e-01	0.076
Minus-strand DNA synthesis	R-HSA-164516	8.388130e-01	0.076
EGFR interacts with phospholipase C-gamma	R-HSA-212718	8.388130e-01	0.076
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	8.388130e-01	0.076
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	8.388130e-01	0.076
Co-stimulation by ICOS	R-HSA-9927354	8.388130e-01	0.076
Interleukin-9 signaling	R-HSA-8985947	8.388130e-01	0.076
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	8.388130e-01	0.076
ROBO receptors bind AKAP5	R-HSA-9010642	8.388130e-01	0.076
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	8.388130e-01	0.076
TGFBR3 PTM regulation	R-HSA-9839383	8.388130e-01	0.076
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	8.388130e-01	0.076
Alpha-defensins	R-HSA-1462054	8.388130e-01	0.076
Interleukin-23 signaling	R-HSA-9020933	8.388130e-01	0.076
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.391081e-01	0.076
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	8.417660e-01	0.075
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	8.422578e-01	0.075
Translesion synthesis by POLI	R-HSA-5656121	8.436798e-01	0.074
Defective GALNT3 causes HFTC	R-HSA-5083625	8.436798e-01	0.074
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.436798e-01	0.074
Atorvastatin ADME	R-HSA-9754706	8.436798e-01	0.074
Regulation of BACH1 activity	R-HSA-9708530	8.436798e-01	0.074
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	8.436798e-01	0.074
Signaling by FGFR2 in disease	R-HSA-5655253	8.445295e-01	0.073
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.465184e-01	0.072
Transport to the Golgi and subsequent modification	R-HSA-948021	8.476869e-01	0.072
Response of Mtb to phagocytosis	R-HSA-9637690	8.477387e-01	0.072
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.562748e-01	0.067
Parasitic Infection Pathways	R-HSA-9824443	8.565564e-01	0.067
Leishmania infection	R-HSA-9658195	8.565564e-01	0.067
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	8.586656e-01	0.066
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.600018e-01	0.066
Amine ligand-binding receptors	R-HSA-375280	8.600018e-01	0.066
Molecules associated with elastic fibres	R-HSA-2129379	8.609242e-01	0.065
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	8.612665e-01	0.065
Neuronal System	R-HSA-112316	8.615751e-01	0.065
Translesion synthesis by POLK	R-HSA-5655862	8.625056e-01	0.064
Passive transport by Aquaporins	R-HSA-432047	8.625056e-01	0.064
Biosynthesis of maresin-like SPMs	R-HSA-9027307	8.625056e-01	0.064
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	8.625056e-01	0.064
Synthesis of PG	R-HSA-1483148	8.625056e-01	0.064
MASTL Facilitates Mitotic Progression	R-HSA-2465910	8.634656e-01	0.064
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	8.634656e-01	0.064
Unwinding of DNA	R-HSA-176974	8.634656e-01	0.064
Activation of the AP-1 family of transcription factors	R-HSA-450341	8.634656e-01	0.064
Interleukin-21 signaling	R-HSA-9020958	8.634656e-01	0.064
mRNA Editing	R-HSA-75072	8.634656e-01	0.064
Regulation of signaling by NODAL	R-HSA-1433617	8.634656e-01	0.064
Regulation of NPAS4 gene transcription	R-HSA-9768777	8.634656e-01	0.064
Interleukin-1 processing	R-HSA-448706	8.634656e-01	0.064
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	8.634656e-01	0.064
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.656603e-01	0.063
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	8.672882e-01	0.062
Uptake and actions of bacterial toxins	R-HSA-5339562	8.672882e-01	0.062
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.735568e-01	0.059
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.735568e-01	0.059
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.792309e-01	0.056
Sulfide oxidation to sulfate	R-HSA-1614517	8.792309e-01	0.056
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.792309e-01	0.056
Integration of energy metabolism	R-HSA-163685	8.825761e-01	0.054
Formation of paraxial mesoderm	R-HSA-9793380	8.838145e-01	0.054
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	8.843489e-01	0.053
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	8.843489e-01	0.053
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	8.843489e-01	0.053
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	8.843489e-01	0.053
Arachidonate production from DAG	R-HSA-426048	8.843489e-01	0.053
Formation of apoptosome	R-HSA-111458	8.843489e-01	0.053
Josephin domain DUBs	R-HSA-5689877	8.843489e-01	0.053
Regulation of the apoptosome activity	R-HSA-9627069	8.843489e-01	0.053
Tandem pore domain potassium channels	R-HSA-1296346	8.843489e-01	0.053
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.870404e-01	0.052
Acyl chain remodelling of PS	R-HSA-1482801	8.870404e-01	0.052
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.872327e-01	0.052
Cardiac conduction	R-HSA-5576891	8.878247e-01	0.052
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.919727e-01	0.050
G beta:gamma signalling through PLC beta	R-HSA-418217	8.940577e-01	0.049
FGFR1 ligand binding and activation	R-HSA-190242	8.940577e-01	0.049
Presynaptic function of Kainate receptors	R-HSA-500657	8.940577e-01	0.049
Vitamin D (calciferol) metabolism	R-HSA-196791	8.940577e-01	0.049
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	8.940577e-01	0.049
Translation of Structural Proteins	R-HSA-9694635	8.958177e-01	0.048
Developmental Cell Lineages	R-HSA-9734767	8.958222e-01	0.048
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.985012e-01	0.046
MET activates PTK2 signaling	R-HSA-8874081	8.992231e-01	0.046
Interleukin-1 family signaling	R-HSA-446652	9.016350e-01	0.045
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	9.020390e-01	0.045
Dissolution of Fibrin Clot	R-HSA-75205	9.020390e-01	0.045
Formation of the posterior neural plate	R-HSA-9832991	9.020390e-01	0.045
FGFR2b ligand binding and activation	R-HSA-190377	9.020390e-01	0.045
Conjugation of benzoate with glycine	R-HSA-177135	9.020390e-01	0.045
vRNA Synthesis	R-HSA-192814	9.020390e-01	0.045
Chylomicron assembly	R-HSA-8963888	9.020390e-01	0.045
Hormone ligand-binding receptors	R-HSA-375281	9.020390e-01	0.045
Cholesterol biosynthesis via desmosterol	R-HSA-6807047	9.020390e-01	0.045
Transport of RCbl within the body	R-HSA-9758890	9.020390e-01	0.045
Vitamin B1 (thiamin) metabolism	R-HSA-196819	9.020390e-01	0.045
rRNA processing	R-HSA-72312	9.055246e-01	0.043
IKK complex recruitment mediated by RIP1	R-HSA-937041	9.071755e-01	0.042
Signaling by FGFR2 IIIa TM	R-HSA-8851708	9.071755e-01	0.042
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.071755e-01	0.042
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.071755e-01	0.042
Maturation of nucleoprotein	R-HSA-9694631	9.071755e-01	0.042
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.075151e-01	0.042
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.075151e-01	0.042
Calnexin/calreticulin cycle	R-HSA-901042	9.075151e-01	0.042
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.077818e-01	0.042
Signaling by BMP	R-HSA-201451	9.102080e-01	0.041
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	9.102080e-01	0.041
Insulin processing	R-HSA-264876	9.102080e-01	0.041
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.167479e-01	0.038
Regulation of Apoptosis	R-HSA-169911	9.167479e-01	0.038
DS-GAG biosynthesis	R-HSA-2022923	9.170241e-01	0.038
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	9.170241e-01	0.038
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	9.170241e-01	0.038
Signaling by activated point mutants of FGFR1	R-HSA-1839122	9.170241e-01	0.038
Protein hydroxylation	R-HSA-9629569	9.187601e-01	0.037
Phase 0 - rapid depolarisation	R-HSA-5576892	9.200942e-01	0.036
Activation of NF-kappaB in B cells	R-HSA-1169091	9.247541e-01	0.034
Hedgehog ligand biogenesis	R-HSA-5358346	9.247541e-01	0.034
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.251472e-01	0.034
Peroxisomal protein import	R-HSA-9033241	9.263374e-01	0.033
Regulation of beta-cell development	R-HSA-186712	9.263374e-01	0.033
Interleukin-1 signaling	R-HSA-9020702	9.283033e-01	0.032
Kidney development	R-HSA-9830369	9.284980e-01	0.032
Basigin interactions	R-HSA-210991	9.289735e-01	0.032
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.289735e-01	0.032
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.289756e-01	0.032
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.291984e-01	0.032
Serotonin clearance from the synaptic cleft	R-HSA-380615	9.297177e-01	0.032
VLDLR internalisation and degradation	R-HSA-8866427	9.297177e-01	0.032
Conjugation of salicylate with glycine	R-HSA-177128	9.297177e-01	0.032
Trafficking and processing of endosomal TLR	R-HSA-1679131	9.297177e-01	0.032
Degradation of AXIN	R-HSA-4641257	9.327755e-01	0.030
Voltage gated Potassium channels	R-HSA-1296072	9.327755e-01	0.030
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.327755e-01	0.030
PI Metabolism	R-HSA-1483255	9.331436e-01	0.030
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.369407e-01	0.028
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.378645e-01	0.028
Somitogenesis	R-HSA-9824272	9.378645e-01	0.028
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.396926e-01	0.027
Elastic fibre formation	R-HSA-1566948	9.396926e-01	0.027
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	9.404700e-01	0.027
FGFR2c ligand binding and activation	R-HSA-190375	9.404700e-01	0.027
Processing of SMDT1	R-HSA-8949664	9.404700e-01	0.027
FGFR4 ligand binding and activation	R-HSA-190322	9.404700e-01	0.027
Diseases of nucleotide metabolism	R-HSA-9735804	9.404700e-01	0.027
Signaling by activated point mutants of FGFR3	R-HSA-1839130	9.404700e-01	0.027
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	9.404700e-01	0.027
Platelet Adhesion to exposed collagen	R-HSA-75892	9.404700e-01	0.027
FGFR3 mutant receptor activation	R-HSA-2033514	9.404700e-01	0.027
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	9.404700e-01	0.027
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	9.404700e-01	0.027
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	9.404700e-01	0.027
Maturation of nucleoprotein	R-HSA-9683610	9.404700e-01	0.027
Immune System	R-HSA-168256	9.430812e-01	0.025
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.438542e-01	0.025
Regulation of TNFR1 signaling	R-HSA-5357905	9.438542e-01	0.025
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.440727e-01	0.025
G alpha (q) signalling events	R-HSA-416476	9.449972e-01	0.025
Free fatty acid receptors	R-HSA-444209	9.458668e-01	0.024
LDL clearance	R-HSA-8964038	9.458668e-01	0.024
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.458668e-01	0.024
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.458668e-01	0.024
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.459552e-01	0.024
Stabilization of p53	R-HSA-69541	9.459552e-01	0.024
Regulation of insulin secretion	R-HSA-422356	9.476088e-01	0.023
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.495779e-01	0.022
Synthesis of IPs in the nucleus	R-HSA-1855191	9.495779e-01	0.022
FGFR3c ligand binding and activation	R-HSA-190372	9.495779e-01	0.022
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	9.495779e-01	0.022
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	9.495779e-01	0.022
Physiological factors	R-HSA-5578768	9.495779e-01	0.022
Malate-aspartate shuttle	R-HSA-9856872	9.495779e-01	0.022
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.495779e-01	0.022
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)	R-HSA-9026766	9.495779e-01	0.022
HDL assembly	R-HSA-8963896	9.495779e-01	0.022
Zinc transporters	R-HSA-435354	9.495779e-01	0.022
Inwardly rectifying K+ channels	R-HSA-1296065	9.504491e-01	0.022
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.516170e-01	0.022
Termination of O-glycan biosynthesis	R-HSA-977068	9.528040e-01	0.021
Interleukin-20 family signaling	R-HSA-8854691	9.528040e-01	0.021
Biosynthesis of maresins	R-HSA-9018682	9.528040e-01	0.021
Formation of the ureteric bud	R-HSA-9830674	9.528040e-01	0.021
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.532135e-01	0.021
TNF signaling	R-HSA-75893	9.532135e-01	0.021
Metal ion SLC transporters	R-HSA-425410	9.542933e-01	0.020
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.553459e-01	0.020
Interferon gamma signaling	R-HSA-877300	9.559957e-01	0.020
Hh mutants are degraded by ERAD	R-HSA-5362768	9.567284e-01	0.019
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	9.572927e-01	0.019
RNA Polymerase III Chain Elongation	R-HSA-73780	9.572927e-01	0.019
G beta:gamma signalling through BTK	R-HSA-8964315	9.572927e-01	0.019
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.572927e-01	0.019
FGFR3 ligand binding and activation	R-HSA-190239	9.572927e-01	0.019
Signaling by Activin	R-HSA-1502540	9.572927e-01	0.019
Protein repair	R-HSA-5676934	9.572927e-01	0.019
Protein lipoylation	R-HSA-9857492	9.572927e-01	0.019
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.588863e-01	0.018
Plasma lipoprotein assembly	R-HSA-8963898	9.588863e-01	0.018
Complex III assembly	R-HSA-9865881	9.588863e-01	0.018
Protein localization	R-HSA-9609507	9.590892e-01	0.018
Glucagon signaling in metabolic regulation	R-HSA-163359	9.612171e-01	0.017
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.612171e-01	0.017
Miscellaneous transport and binding events	R-HSA-5223345	9.612171e-01	0.017
Translation of Structural Proteins	R-HSA-9683701	9.613368e-01	0.017
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.615651e-01	0.017
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.620047e-01	0.017
ER-Phagosome pathway	R-HSA-1236974	9.622664e-01	0.017
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	9.638275e-01	0.016
Activation of the phototransduction cascade	R-HSA-2485179	9.638275e-01	0.016
Differentiation of T cells	R-HSA-9945266	9.638275e-01	0.016
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	9.638275e-01	0.016
Regulation of NF-kappa B signaling	R-HSA-9758274	9.638275e-01	0.016
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	9.638275e-01	0.016
Attachment and Entry	R-HSA-9678110	9.638275e-01	0.016
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.642126e-01	0.016
G protein gated Potassium channels	R-HSA-1296059	9.642126e-01	0.016
Activation of G protein gated Potassium channels	R-HSA-1296041	9.642126e-01	0.016
Laminin interactions	R-HSA-3000157	9.642126e-01	0.016
Hyaluronan degradation	R-HSA-2160916	9.642126e-01	0.016
Downstream TCR signaling	R-HSA-202424	9.652924e-01	0.015
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.654863e-01	0.015
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.657363e-01	0.015
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.657363e-01	0.015
Hyaluronan metabolism	R-HSA-2142845	9.657363e-01	0.015
NPAS4 regulates expression of target genes	R-HSA-9768919	9.657363e-01	0.015
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.660708e-01	0.015
The phototransduction cascade	R-HSA-2514856	9.666635e-01	0.015
Selenoamino acid metabolism	R-HSA-2408522	9.678863e-01	0.014
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.688719e-01	0.014
Sphingolipid catabolism	R-HSA-9845614	9.688719e-01	0.014
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.688719e-01	0.014
Urea cycle	R-HSA-70635	9.688719e-01	0.014
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.692180e-01	0.014
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.693627e-01	0.014
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.693627e-01	0.014
Scavenging by Class B Receptors	R-HSA-3000471	9.693627e-01	0.014
Vitamin B6 activation to pyridoxal phosphate	R-HSA-964975	9.693627e-01	0.014
Phase 2 - plateau phase	R-HSA-5576893	9.693627e-01	0.014
Coenzyme A biosynthesis	R-HSA-196783	9.693627e-01	0.014
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.693627e-01	0.014
Galactose catabolism	R-HSA-70370	9.693627e-01	0.014
C-type lectin receptors (CLRs)	R-HSA-5621481	9.694388e-01	0.013
FCERI mediated MAPK activation	R-HSA-2871796	9.703881e-01	0.013
Aquaporin-mediated transport	R-HSA-445717	9.715673e-01	0.013
Surfactant metabolism	R-HSA-5683826	9.725700e-01	0.012
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.729156e-01	0.012
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.729437e-01	0.012
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.729437e-01	0.012
Triglyceride biosynthesis	R-HSA-75109	9.729437e-01	0.012
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.729437e-01	0.012
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.729437e-01	0.012
Integrin cell surface interactions	R-HSA-216083	9.729869e-01	0.012
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.731063e-01	0.012
Triglyceride catabolism	R-HSA-163560	9.733250e-01	0.012
Infectious disease	R-HSA-5663205	9.735548e-01	0.012
Platelet homeostasis	R-HSA-418346	9.740351e-01	0.011
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.740512e-01	0.011
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.740512e-01	0.011
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.740512e-01	0.011
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.753327e-01	0.011
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.753921e-01	0.011
Asymmetric localization of PCP proteins	R-HSA-4608870	9.755774e-01	0.011
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.755774e-01	0.011
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.760775e-01	0.011
Prednisone ADME	R-HSA-9757110	9.764985e-01	0.010
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.764985e-01	0.010
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.780224e-01	0.010
Activated point mutants of FGFR2	R-HSA-2033519	9.780224e-01	0.010
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	9.780224e-01	0.010
Biosynthesis of DHA-derived sulfido conjugates	R-HSA-9026395	9.780224e-01	0.010
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.782728e-01	0.010
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.795992e-01	0.009
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.795992e-01	0.009
tRNA processing	R-HSA-72306	9.797609e-01	0.009
Interferon alpha/beta signaling	R-HSA-909733	9.800688e-01	0.009
Pyrimidine biosynthesis	R-HSA-500753	9.813860e-01	0.008
Conjugation of carboxylic acids	R-HSA-159424	9.813860e-01	0.008
Amino Acid conjugation	R-HSA-156587	9.813860e-01	0.008
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.813860e-01	0.008
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	9.813860e-01	0.008
Methionine salvage pathway	R-HSA-1237112	9.813860e-01	0.008
RAS processing	R-HSA-9648002	9.817856e-01	0.008
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.817856e-01	0.008
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.823015e-01	0.008
Potassium Channels	R-HSA-1296071	9.826578e-01	0.008
Neurotransmitter release cycle	R-HSA-112310	9.828109e-01	0.008
Glycogen metabolism	R-HSA-8982491	9.839843e-01	0.007
SLC transporter disorders	R-HSA-5619102	9.840026e-01	0.007
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.842350e-01	0.007
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.842350e-01	0.007
Keratan sulfate degradation	R-HSA-2022857	9.842350e-01	0.007
Glycogen synthesis	R-HSA-3322077	9.842350e-01	0.007
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.859275e-01	0.006
Aflatoxin activation and detoxification	R-HSA-5423646	9.859275e-01	0.006
Triglyceride metabolism	R-HSA-8979227	9.861488e-01	0.006
G-protein activation	R-HSA-202040	9.866481e-01	0.006
FGFR2 ligand binding and activation	R-HSA-190241	9.866481e-01	0.006
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	9.866481e-01	0.006
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.866481e-01	0.006
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.866481e-01	0.006
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	9.866481e-01	0.006
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.867023e-01	0.006
Defective B3GALTL causes PpS	R-HSA-5083635	9.884828e-01	0.005
CS-GAG biosynthesis	R-HSA-2022870	9.886920e-01	0.005
Eicosanoids	R-HSA-211979	9.886920e-01	0.005
Miscellaneous substrates	R-HSA-211958	9.886920e-01	0.005
Molybdenum cofactor biosynthesis	R-HSA-947581	9.886920e-01	0.005
Glutathione synthesis and recycling	R-HSA-174403	9.886920e-01	0.005
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.886920e-01	0.005
Attachment and Entry	R-HSA-9694614	9.886920e-01	0.005
Ribavirin ADME	R-HSA-9755088	9.886920e-01	0.005
Antigen processing-Cross presentation	R-HSA-1236975	9.888428e-01	0.005
Extracellular matrix organization	R-HSA-1474244	9.896054e-01	0.005
Pyruvate metabolism	R-HSA-70268	9.896975e-01	0.004
Vpu mediated degradation of CD4	R-HSA-180534	9.900299e-01	0.004
Heme degradation	R-HSA-189483	9.900299e-01	0.004
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.900988e-01	0.004
Metabolism of cofactors	R-HSA-8978934	9.900988e-01	0.004
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.904230e-01	0.004
Neurotoxicity of clostridium toxins	R-HSA-168799	9.904230e-01	0.004
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.904230e-01	0.004
Ethanol oxidation	R-HSA-71384	9.904230e-01	0.004
Amino acids regulate mTORC1	R-HSA-9639288	9.906149e-01	0.004
eNOS activation	R-HSA-203615	9.913734e-01	0.004
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.913734e-01	0.004
NOD1/2 Signaling Pathway	R-HSA-168638	9.913734e-01	0.004
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.916657e-01	0.004
Fatty acids	R-HSA-211935	9.918892e-01	0.004
Organic anion transport by SLCO transporters	R-HSA-879518	9.918892e-01	0.004
Carnitine shuttle	R-HSA-200425	9.918892e-01	0.004
Xenobiotics	R-HSA-211981	9.921868e-01	0.003
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.926998e-01	0.003
CYP2E1 reactions	R-HSA-211999	9.931310e-01	0.003
Mitochondrial RNA degradation	R-HSA-9836573	9.931310e-01	0.003
TNFs bind their physiological receptors	R-HSA-5669034	9.931310e-01	0.003
FGFR2 mutant receptor activation	R-HSA-1839126	9.935504e-01	0.003
Regulation of pyruvate metabolism	R-HSA-9861718	9.936092e-01	0.003
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.941827e-01	0.003
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.941827e-01	0.003
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.941827e-01	0.003
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.941827e-01	0.003
Retinoid cycle disease events	R-HSA-2453864	9.941827e-01	0.003
Diseases of the neuronal system	R-HSA-9675143	9.941827e-01	0.003
Diseases associated with visual transduction	R-HSA-2474795	9.941827e-01	0.003
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.941827e-01	0.003
Innate Immune System	R-HSA-168249	9.942454e-01	0.003
Dectin-2 family	R-HSA-5621480	9.942750e-01	0.002
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.944084e-01	0.002
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.944084e-01	0.002
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.944269e-01	0.002
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.944269e-01	0.002
Attachment of bacteria to epithelial cells	R-HSA-9638630	9.950734e-01	0.002
Suppression of phagosomal maturation	R-HSA-9637687	9.950734e-01	0.002
Purine salvage	R-HSA-74217	9.951863e-01	0.002
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.951863e-01	0.002
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.958278e-01	0.002
Pentose phosphate pathway	R-HSA-71336	9.958438e-01	0.002
Plasma lipoprotein clearance	R-HSA-8964043	9.958438e-01	0.002
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.958438e-01	0.002
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.960725e-01	0.002
Azathioprine ADME	R-HSA-9748787	9.962664e-01	0.002
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.964129e-01	0.002
Insulin receptor recycling	R-HSA-77387	9.964667e-01	0.002
Pyrimidine salvage	R-HSA-73614	9.964667e-01	0.002
Collagen degradation	R-HSA-1442490	9.965398e-01	0.002
ECM proteoglycans	R-HSA-3000178	9.965846e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.966279e-01	0.001
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.966793e-01	0.001
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.970078e-01	0.001
Glucagon-type ligand receptors	R-HSA-420092	9.970078e-01	0.001
Aspirin ADME	R-HSA-9749641	9.973172e-01	0.001
Complex I biogenesis	R-HSA-6799198	9.973185e-01	0.001
Intra-Golgi traffic	R-HSA-6811438	9.973308e-01	0.001
Neurotransmitter clearance	R-HSA-112311	9.974661e-01	0.001
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.978542e-01	0.001
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.978889e-01	0.001
Iron uptake and transport	R-HSA-917937	9.978970e-01	0.001
HS-GAG degradation	R-HSA-2024096	9.981829e-01	0.001
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.982911e-01	0.001
Proteasome assembly	R-HSA-9907900	9.982911e-01	0.001
Keratan sulfate biosynthesis	R-HSA-2022854	9.984612e-01	0.001
Recycling of bile acids and salts	R-HSA-159418	9.984612e-01	0.001
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.984612e-01	0.001
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.985280e-01	0.001
Degradation of cysteine and homocysteine	R-HSA-1614558	9.985280e-01	0.001
ABC transporter disorders	R-HSA-5619084	9.985458e-01	0.001
Synthesis of PA	R-HSA-1483166	9.985688e-01	0.001
CS/DS degradation	R-HSA-2024101	9.986969e-01	0.001
Acyl chain remodelling of PC	R-HSA-1482788	9.986969e-01	0.001
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.988966e-01	0.000
RA biosynthesis pathway	R-HSA-5365859	9.988966e-01	0.000
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.989089e-01	0.000
Synthesis of PC	R-HSA-1483191	9.989089e-01	0.000
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.989158e-01	0.000
RAB geranylgeranylation	R-HSA-8873719	9.990569e-01	0.000
Acyl chain remodelling of PE	R-HSA-1482839	9.990656e-01	0.000
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.990656e-01	0.000
Transferrin endocytosis and recycling	R-HSA-917977	9.990656e-01	0.000
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.990656e-01	0.000
Formation of the cornified envelope	R-HSA-6809371	9.991681e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.991799e-01	0.000
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.992208e-01	0.000
ABC-family proteins mediated transport	R-HSA-382556	9.992385e-01	0.000
Post-translational protein modification	R-HSA-597592	9.992906e-01	0.000
Neddylation	R-HSA-8951664	9.993080e-01	0.000
Ubiquinol biosynthesis	R-HSA-2142789	9.993300e-01	0.000
SLC-mediated transport of organic cations	R-HSA-549127	9.993300e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.993357e-01	0.000
Complex IV assembly	R-HSA-9864848	9.994025e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.994154e-01	0.000
Biofilm formation	R-HSA-9931953	9.994327e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.994412e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.994540e-01	0.000
Disease	R-HSA-1643685	9.995040e-01	0.000
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.995196e-01	0.000
Nucleotide biosynthesis	R-HSA-8956320	9.995585e-01	0.000
Glucuronidation	R-HSA-156588	9.996206e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.996481e-01	0.000
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.996556e-01	0.000
Paracetamol ADME	R-HSA-9753281	9.996740e-01	0.000
Scavenging by Class A Receptors	R-HSA-3000480	9.997084e-01	0.000
Heme biosynthesis	R-HSA-189451	9.997084e-01	0.000
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.997084e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.997159e-01	0.000
Cytosolic tRNA aminoacylation	R-HSA-379716	9.997531e-01	0.000
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.997531e-01	0.000
Defensins	R-HSA-1461973	9.997909e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.998010e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.998479e-01	0.000
Metabolism of polyamines	R-HSA-351202	9.998479e-01	0.000
The canonical retinoid cycle in rods (twilight vision)	R-HSA-2453902	9.998501e-01	0.000
Collagen formation	R-HSA-1474290	9.998532e-01	0.000
Endogenous sterols	R-HSA-211976	9.998695e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.998744e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.998744e-01	0.000
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.998898e-01	0.000
Plasma lipoprotein remodeling	R-HSA-8963899	9.999090e-01	0.000
Keratan sulfate/keratin metabolism	R-HSA-1638074	9.999230e-01	0.000
Chemokine receptors bind chemokines	R-HSA-380108	9.999230e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.999274e-01	0.000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.999348e-01	0.000
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.999395e-01	0.000
SLC-mediated transport of amino acids	R-HSA-9958863	9.999481e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999531e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.999555e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.999555e-01	0.000
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.999581e-01	0.000
FCGR activation	R-HSA-2029481	9.999635e-01	0.000
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.999716e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.999720e-01	0.000
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.999761e-01	0.000
Purine catabolism	R-HSA-74259	9.999761e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999768e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999788e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999789e-01	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999803e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999805e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.999824e-01	0.000
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.999854e-01	0.000
Amino acid transport across the plasma membrane	R-HSA-352230	9.999854e-01	0.000
Sialic acid metabolism	R-HSA-4085001	9.999854e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999863e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.999877e-01	0.000
Glutathione conjugation	R-HSA-156590	9.999877e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999894e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999919e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.999937e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999941e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.999947e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.999962e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999963e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999964e-01	0.000
Translation	R-HSA-72766	9.999967e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999973e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999975e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999976e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.999977e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999988e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999994e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999996e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999996e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999997e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999997e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999997e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999998e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999998e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999999e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999999e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.999999e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999999e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	1.000000e+00	0.000
Keratinization	R-HSA-6805567	1.000000e+00	0.000
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000
Regulation of Complement cascade	R-HSA-977606	1.000000e+00	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Complement cascade	R-HSA-166658	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.110223e-16	15.955
Eukaryotic Translation Elongation	R-HSA-156842	1.110223e-16	15.955
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.110223e-16	15.955
Eukaryotic Translation Initiation	R-HSA-72613	1.110223e-16	15.955
Cap-dependent Translation Initiation	R-HSA-72737	1.110223e-16	15.955
Cellular response to heat stress	R-HSA-3371556	1.110223e-16	15.955
Cell Cycle, Mitotic	R-HSA-69278	1.110223e-16	15.955
Cell-Cell communication	R-HSA-1500931	1.110223e-16	15.955
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955
M Phase	R-HSA-68886	1.110223e-16	15.955
Axon guidance	R-HSA-422475	1.110223e-16	15.955
Nervous system development	R-HSA-9675108	1.110223e-16	15.955
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955
Metabolism of RNA	R-HSA-8953854	1.110223e-16	15.955
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955
Signaling by ROBO receptors	R-HSA-376176	1.110223e-16	15.955
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	8.881784e-16	15.051
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.221245e-15	14.913
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.330669e-15	14.477
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.551914e-15	14.342
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.551914e-15	14.342
Peptide chain elongation	R-HSA-156902	7.882583e-15	14.103
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	7.993606e-15	14.097
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	7.438494e-15	14.129
Influenza Infection	R-HSA-168255	7.660539e-15	14.116
Formation of a pool of free 40S subunits	R-HSA-72689	1.110223e-14	13.955
Cell junction organization	R-HSA-446728	1.953993e-14	13.709
Apoptosis	R-HSA-109581	2.997602e-14	13.523
Mitotic Anaphase	R-HSA-68882	5.084821e-14	13.294
Influenza Viral RNA Transcription and Replication	R-HSA-168273	5.395684e-14	13.268
Ribosome-associated quality control	R-HSA-9948299	6.128431e-14	13.213
Mitotic Metaphase and Anaphase	R-HSA-2555396	6.250556e-14	13.204
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	8.160139e-14	13.088
Translation initiation complex formation	R-HSA-72649	1.024736e-13	12.989
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.232348e-13	12.909
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.233458e-13	12.909
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.249001e-13	12.903
HSF1-dependent transactivation	R-HSA-3371571	1.303402e-13	12.885
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.858513e-13	12.731
Ribosomal scanning and start codon recognition	R-HSA-72702	2.490230e-13	12.604
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	2.483569e-13	12.605
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	3.611555e-13	12.442
Regulation of CDH1 Expression and Function	R-HSA-9764265	4.859446e-13	12.313
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	4.859446e-13	12.313
mRNA Splicing - Major Pathway	R-HSA-72163	6.266099e-13	12.203
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.443179e-12	11.841
Adherens junctions interactions	R-HSA-418990	1.565748e-12	11.805
Attenuation phase	R-HSA-3371568	1.574185e-12	11.803
Apoptotic execution phase	R-HSA-75153	1.680656e-12	11.775
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.122746e-12	11.673
Eukaryotic Translation Termination	R-HSA-72764	2.395195e-12	11.621
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.566392e-12	11.591
Separation of Sister Chromatids	R-HSA-2467813	4.002576e-12	11.398
Cell-cell junction organization	R-HSA-421270	5.199396e-12	11.284
Oxidative Stress Induced Senescence	R-HSA-2559580	5.243250e-12	11.280
mRNA Splicing	R-HSA-72172	5.599188e-12	11.252
SARS-CoV-1-host interactions	R-HSA-9692914	6.171397e-12	11.210
Viral Infection Pathways	R-HSA-9824446	6.693091e-12	11.174
Programmed Cell Death	R-HSA-5357801	6.775580e-12	11.169
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	7.185030e-12	11.144
Developmental Biology	R-HSA-1266738	1.149758e-11	10.939
L1CAM interactions	R-HSA-373760	1.358058e-11	10.867
Selenocysteine synthesis	R-HSA-2408557	1.379408e-11	10.860
Cell Cycle Checkpoints	R-HSA-69620	1.689537e-11	10.772
Viral mRNA Translation	R-HSA-192823	2.402534e-11	10.619
Interleukin-12 signaling	R-HSA-9020591	2.532596e-11	10.596
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	3.056133e-11	10.515
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	4.692302e-11	10.329
Cellular Senescence	R-HSA-2559583	4.695111e-11	10.328
Recycling pathway of L1	R-HSA-437239	6.168588e-11	10.210
SARS-CoV-2-host interactions	R-HSA-9705683	6.339795e-11	10.198
Cellular response to starvation	R-HSA-9711097	7.554057e-11	10.122
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.063873e-10	9.973
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.475607e-10	9.831
HSF1 activation	R-HSA-3371511	1.763497e-10	9.754
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.890343e-10	9.723
Mitotic Prometaphase	R-HSA-68877	2.021469e-10	9.694
Post NMDA receptor activation events	R-HSA-438064	2.685961e-10	9.571
Interleukin-12 family signaling	R-HSA-447115	2.685961e-10	9.571
Cytokine Signaling in Immune system	R-HSA-1280215	2.879147e-10	9.541
Signal Transduction	R-HSA-162582	3.745875e-10	9.426
Apoptotic cleavage of cellular proteins	R-HSA-111465	4.365748e-10	9.360
Interferon Signaling	R-HSA-913531	4.380943e-10	9.358
G2/M Checkpoints	R-HSA-69481	7.251653e-10	9.140
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.820685e-10	9.054
Mitotic Prophase	R-HSA-68875	1.070983e-09	8.970
PKR-mediated signaling	R-HSA-9833482	1.184442e-09	8.926
Transcriptional regulation by small RNAs	R-HSA-5578749	1.452496e-09	8.838
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.780688e-09	8.749
rRNA processing	R-HSA-72312	1.725869e-09	8.763
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.799726e-09	8.745
Nucleosome assembly	R-HSA-774815	2.546109e-09	8.594
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.546109e-09	8.594
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.901739e-09	8.537
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	3.797638e-09	8.420
Regulation of CDH1 Function	R-HSA-9764561	1.002088e-08	7.999
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.338022e-08	7.874
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.378100e-08	7.861
SARS-CoV-1 Infection	R-HSA-9678108	1.473593e-08	7.832
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.599915e-08	7.796
Assembly of the pre-replicative complex	R-HSA-68867	1.800836e-08	7.745
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.821256e-08	7.740
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.975517e-08	7.704
Deubiquitination	R-HSA-5688426	2.094627e-08	7.679
Aggrephagy	R-HSA-9646399	2.147844e-08	7.668
Ub-specific processing proteases	R-HSA-5689880	2.596883e-08	7.586
Transport of connexons to the plasma membrane	R-HSA-190872	2.922722e-08	7.534
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	3.846872e-08	7.415
ISG15 antiviral mechanism	R-HSA-1169408	4.085683e-08	7.389
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	4.493071e-08	7.347
Transcriptional regulation by RUNX1	R-HSA-8878171	4.517949e-08	7.345
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	4.530018e-08	7.344
Estrogen-dependent gene expression	R-HSA-9018519	4.992938e-08	7.302
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	6.830098e-08	7.166
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	7.088886e-08	7.149
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	9.143440e-08	7.039
DNA Replication Pre-Initiation	R-HSA-69002	1.089347e-07	6.963
EPH-Ephrin signaling	R-HSA-2682334	1.308869e-07	6.883
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.395529e-07	6.855
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.508609e-07	6.821
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.821245e-07	6.740
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.812756e-07	6.742
DNA Double Strand Break Response	R-HSA-5693606	1.819233e-07	6.740
G2/M Transition	R-HSA-69275	1.951392e-07	6.710
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.311464e-07	6.636
Regulation of T cell activation by CD28 family	R-HSA-388841	2.324136e-07	6.634
Mitotic G2-G2/M phases	R-HSA-453274	2.609793e-07	6.583
HDACs deacetylate histones	R-HSA-3214815	2.710241e-07	6.567
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.158606e-07	6.501
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.564001e-07	6.448
Diseases of programmed cell death	R-HSA-9645723	3.760367e-07	6.425
Selenoamino acid metabolism	R-HSA-2408522	4.163553e-07	6.381
Downregulation of ERBB2 signaling	R-HSA-8863795	5.177985e-07	6.286
Gene Silencing by RNA	R-HSA-211000	5.486973e-07	6.261
Signaling by Hippo	R-HSA-2028269	5.963923e-07	6.224
Signaling by RAF1 mutants	R-HSA-9656223	7.179319e-07	6.144
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	8.081248e-07	6.093
Signaling downstream of RAS mutants	R-HSA-9649948	8.988217e-07	6.046
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	8.988217e-07	6.046
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	8.988217e-07	6.046
Signaling by WNT	R-HSA-195721	8.916959e-07	6.050
Signaling by RAS mutants	R-HSA-6802949	8.988217e-07	6.046
ESR-mediated signaling	R-HSA-8939211	8.757355e-07	6.058
Host Interactions of HIV factors	R-HSA-162909	9.794631e-07	6.009
SARS-CoV-2 Infection	R-HSA-9694516	9.859404e-07	6.006
Signaling by ERBB2	R-HSA-1227986	1.053949e-06	5.977
Activation of AMPK downstream of NMDARs	R-HSA-9619483	1.059738e-06	5.975
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.536598e-06	5.813
PRC2 methylates histones and DNA	R-HSA-212300	1.536598e-06	5.813
TCF dependent signaling in response to WNT	R-HSA-201681	1.437868e-06	5.842
Translation	R-HSA-72766	1.418730e-06	5.848
SARS-CoV Infections	R-HSA-9679506	1.429514e-06	5.845
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.606418e-06	5.794
Neutrophil degranulation	R-HSA-6798695	1.656105e-06	5.781
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.745297e-06	5.758
Meiotic synapsis	R-HSA-1221632	1.850699e-06	5.733
Gap junction trafficking and regulation	R-HSA-157858	2.124937e-06	5.673
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.355628e-06	5.628
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	2.410290e-06	5.618
Post-chaperonin tubulin folding pathway	R-HSA-389977	2.586543e-06	5.587
MAPK family signaling cascades	R-HSA-5683057	2.789442e-06	5.554
Selective autophagy	R-HSA-9663891	3.031454e-06	5.518
G2/M DNA damage checkpoint	R-HSA-69473	3.044952e-06	5.516
Intracellular signaling by second messengers	R-HSA-9006925	3.183426e-06	5.497
RNA Polymerase I Promoter Opening	R-HSA-73728	3.188894e-06	5.496
Regulation of endogenous retroelements	R-HSA-9842860	3.302528e-06	5.481
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.406214e-06	5.468
HCMV Early Events	R-HSA-9609690	3.653665e-06	5.437
Oncogenic MAPK signaling	R-HSA-6802957	3.764924e-06	5.424
KEAP1-NFE2L2 pathway	R-HSA-9755511	3.913265e-06	5.407
Nuclear Envelope Breakdown	R-HSA-2980766	5.141424e-06	5.289
Co-inhibition by PD-1	R-HSA-389948	5.983374e-06	5.223
Assembly of the ORC complex at the origin of replication	R-HSA-68616	6.347923e-06	5.197
Gap junction trafficking	R-HSA-190828	6.346575e-06	5.197
DNA methylation	R-HSA-5334118	6.586237e-06	5.181
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	6.586237e-06	5.181
Infectious disease	R-HSA-5663205	7.033257e-06	5.153
RNA Polymerase I Transcription	R-HSA-73864	7.087820e-06	5.149
Degradation of CDH1	R-HSA-9766229	7.163346e-06	5.145
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	8.034696e-06	5.095
Striated Muscle Contraction	R-HSA-390522	8.760215e-06	5.057
HIV Infection	R-HSA-162906	9.243594e-06	5.034
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	9.365321e-06	5.028
Signaling by ALK in cancer	R-HSA-9700206	9.365321e-06	5.028
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.317139e-05	4.880
Chromatin organization	R-HSA-4839726	1.334906e-05	4.875
EPHA-mediated growth cone collapse	R-HSA-3928663	1.347960e-05	4.870
Packaging Of Telomere Ends	R-HSA-171306	1.347960e-05	4.870
mRNA 3'-end processing	R-HSA-72187	1.515674e-05	4.819
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.636864e-05	4.786
PTEN Regulation	R-HSA-6807070	1.577376e-05	4.802
Oncogene Induced Senescence	R-HSA-2559585	1.617054e-05	4.791
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.556798e-05	4.808
Defective pyroptosis	R-HSA-9710421	1.644963e-05	4.784
Chaperonin-mediated protein folding	R-HSA-390466	1.796235e-05	4.746
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.901998e-05	4.721
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.942735e-05	4.712
Chromatin modifying enzymes	R-HSA-3247509	1.966218e-05	4.706
Membrane Trafficking	R-HSA-199991	2.011380e-05	4.697
Chromosome Maintenance	R-HSA-73886	2.035156e-05	4.691
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.150412e-05	4.667
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.205173e-05	4.657
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	2.416256e-05	4.617
DNA Double-Strand Break Repair	R-HSA-5693532	2.471524e-05	4.607
DNA Replication	R-HSA-69306	2.471524e-05	4.607
Ephrin signaling	R-HSA-3928664	2.599288e-05	4.585
Folding of actin by CCT/TriC	R-HSA-390450	3.132090e-05	4.504
PIP3 activates AKT signaling	R-HSA-1257604	2.876319e-05	4.541
MAPK1/MAPK3 signaling	R-HSA-5684996	3.150219e-05	4.502
RAF/MAP kinase cascade	R-HSA-5673001	2.996244e-05	4.523
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	3.128307e-05	4.505
MAP2K and MAPK activation	R-HSA-5674135	3.242185e-05	4.489
Gene expression (Transcription)	R-HSA-74160	3.386123e-05	4.470
UCH proteinases	R-HSA-5689603	3.573141e-05	4.447
Signaling by NOTCH	R-HSA-157118	3.632870e-05	4.440
NoRC negatively regulates rRNA expression	R-HSA-427413	3.699255e-05	4.432
Cargo trafficking to the periciliary membrane	R-HSA-5620920	3.699255e-05	4.432
RNA Polymerase II Transcription Termination	R-HSA-73856	3.823863e-05	4.417
Immune System	R-HSA-168256	3.953503e-05	4.403
Signaling by Interleukins	R-HSA-449147	4.258993e-05	4.371
Gap junction assembly	R-HSA-190861	4.335962e-05	4.363
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.472165e-05	4.349
Mitotic G1 phase and G1/S transition	R-HSA-453279	4.561928e-05	4.341
Protein folding	R-HSA-391251	5.065417e-05	4.295
Semaphorin interactions	R-HSA-373755	5.763528e-05	4.239
Regulation of PTEN stability and activity	R-HSA-8948751	5.799437e-05	4.237
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	6.088784e-05	4.215
Downregulation of ERBB4 signaling	R-HSA-1253288	6.088784e-05	4.215
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.241021e-05	4.205
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	6.539916e-05	4.184
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.373361e-05	4.132
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.187201e-05	4.087
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.207336e-05	4.086
Processing of DNA double-strand break ends	R-HSA-5693607	8.765325e-05	4.057
Platelet activation, signaling and aggregation	R-HSA-76002	8.008589e-05	4.096
Cellular response to chemical stress	R-HSA-9711123	8.364439e-05	4.078
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	9.719402e-05	4.012
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.719402e-05	4.012
Muscle contraction	R-HSA-397014	9.728881e-05	4.012
VEGFA-VEGFR2 Pathway	R-HSA-4420097	9.979924e-05	4.001
MITF-M-regulated melanocyte development	R-HSA-9730414	1.074546e-04	3.969
Cell-extracellular matrix interactions	R-HSA-446353	1.113465e-04	3.953
Activation of BAD and translocation to mitochondria	R-HSA-111447	1.113465e-04	3.953
Chaperone Mediated Autophagy	R-HSA-9613829	1.184245e-04	3.927
S Phase	R-HSA-69242	1.211351e-04	3.917
Transcriptional regulation by RUNX3	R-HSA-8878159	1.297650e-04	3.887
PCP/CE pathway	R-HSA-4086400	1.319356e-04	3.880
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.321012e-04	3.879
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.358649e-04	3.867
Orc1 removal from chromatin	R-HSA-68949	1.358649e-04	3.867
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.482654e-04	3.829
Meiosis	R-HSA-1500620	1.697931e-04	3.770
MAPK6/MAPK4 signaling	R-HSA-5687128	1.697931e-04	3.770
Apoptosis induced DNA fragmentation	R-HSA-140342	1.888660e-04	3.724
Protein ubiquitination	R-HSA-8852135	1.985372e-04	3.702
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	1.989083e-04	3.701
Glycolysis	R-HSA-70171	2.010259e-04	3.697
Cohesin Loading onto Chromatin	R-HSA-2470946	2.189536e-04	3.660
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.316327e-04	3.635
Signal transduction by L1	R-HSA-445144	2.402647e-04	3.619
Nephrin family interactions	R-HSA-373753	2.402647e-04	3.619
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	2.481625e-04	3.605
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.545572e-04	3.594
PECAM1 interactions	R-HSA-210990	3.085643e-04	3.511
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	3.085643e-04	3.511
Regulation of MECP2 expression and activity	R-HSA-9022692	2.927460e-04	3.534
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.986724e-04	3.525
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.085643e-04	3.511
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.833314e-04	3.548
Cleavage of the damaged purine	R-HSA-110331	3.103237e-04	3.508
Meiotic recombination	R-HSA-912446	3.114115e-04	3.507
Condensation of Prophase Chromosomes	R-HSA-2299718	3.178273e-04	3.498
Regulation of KIT signaling	R-HSA-1433559	3.495157e-04	3.457
Switching of origins to a post-replicative state	R-HSA-69052	3.521036e-04	3.453
RNA Polymerase I Promoter Escape	R-HSA-73772	3.783773e-04	3.422
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	3.858779e-04	3.414
HATs acetylate histones	R-HSA-3214847	3.903852e-04	3.409
Depurination	R-HSA-73927	3.907128e-04	3.408
Macroautophagy	R-HSA-1632852	3.937559e-04	3.405
Long-term potentiation	R-HSA-9620244	4.013508e-04	3.396
TCR signaling	R-HSA-202403	4.045476e-04	3.393
Signaling by VEGF	R-HSA-194138	4.072762e-04	3.390
Hedgehog 'off' state	R-HSA-5610787	4.467548e-04	3.350
Beta-catenin independent WNT signaling	R-HSA-3858494	4.473721e-04	3.349
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.574774e-04	3.340
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.658691e-04	3.332
Amplification of signal from the kinetochores	R-HSA-141424	4.658691e-04	3.332
Nuclear import of Rev protein	R-HSA-180746	4.766947e-04	3.322
Epigenetic regulation of gene expression	R-HSA-212165	4.815340e-04	3.317
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	4.839915e-04	3.315
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.883323e-04	3.311
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.883323e-04	3.311
Depolymerization of the Nuclear Lamina	R-HSA-4419969	4.963293e-04	3.304
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.129954e-04	3.290
HCMV Infection	R-HSA-9609646	5.190606e-04	3.285
Cyclin E associated events during G1/S transition	R-HSA-69202	5.284611e-04	3.277
RNA Polymerase II Transcription	R-HSA-73857	5.361775e-04	3.271
Clathrin-mediated endocytosis	R-HSA-8856828	5.462939e-04	3.263
Regulation of signaling by CBL	R-HSA-912631	6.848233e-04	3.164
mTORC1-mediated signalling	R-HSA-166208	6.106876e-04	3.214
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	5.764279e-04	3.239
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	6.006902e-04	3.221
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	6.060761e-04	3.217
EPHB-mediated forward signaling	R-HSA-3928662	5.970062e-04	3.224
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.196449e-04	3.208
Regulation of mitotic cell cycle	R-HSA-453276	6.196449e-04	3.208
HIV Life Cycle	R-HSA-162587	6.370668e-04	3.196
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	6.887176e-04	3.162
Regulation of RUNX3 expression and activity	R-HSA-8941858	6.060761e-04	3.217
Interactions of Rev with host cellular proteins	R-HSA-177243	6.060761e-04	3.217
Interactions of Vpr with host cellular proteins	R-HSA-176033	6.060761e-04	3.217
Homology Directed Repair	R-HSA-5693538	6.614697e-04	3.179
Autophagy	R-HSA-9612973	5.755005e-04	3.240
Kinesins	R-HSA-983189	6.172509e-04	3.210
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	7.327013e-04	3.135
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	7.471763e-04	3.127
Regulation of TP53 Degradation	R-HSA-6804757	7.510173e-04	3.124
Nef and signal transduction	R-HSA-164944	7.852613e-04	3.105
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.861789e-04	3.104
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	7.956920e-04	3.099
G1/S Transition	R-HSA-69206	8.215258e-04	3.085
Regulation of TP53 Activity	R-HSA-5633007	8.581045e-04	3.066
Transcriptional regulation of granulopoiesis	R-HSA-9616222	8.630558e-04	3.064
Transport of the SLBP independent Mature mRNA	R-HSA-159227	9.252900e-04	3.034
Degradation of DVL	R-HSA-4641258	9.319605e-04	3.031
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.341411e-04	3.030
Mitotic Spindle Checkpoint	R-HSA-69618	9.592868e-04	3.018
Signaling by NOTCH4	R-HSA-9013694	9.795828e-04	3.009
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.014647e-03	2.994
Signaling by PTK6	R-HSA-8848021	1.014647e-03	2.994
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.016859e-03	2.993
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	1.016859e-03	2.993
Organelle biogenesis and maintenance	R-HSA-1852241	1.018534e-03	2.992
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.031880e-03	2.986
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.058807e-03	2.975
Neurodegenerative Diseases	R-HSA-8863678	1.058807e-03	2.975
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.075208e-03	2.969
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.111941e-03	2.954
Cleavage of the damaged pyrimidine	R-HSA-110329	1.114162e-03	2.953
Depyrimidination	R-HSA-73928	1.114162e-03	2.953
MITF-M-dependent gene expression	R-HSA-9856651	1.120503e-03	2.951
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.148264e-03	2.940
DNA Damage Recognition in GG-NER	R-HSA-5696394	1.157278e-03	2.937
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.157278e-03	2.937
Amyloid fiber formation	R-HSA-977225	1.173792e-03	2.930
Smooth Muscle Contraction	R-HSA-445355	1.191442e-03	2.924
Unfolded Protein Response (UPR)	R-HSA-381119	1.197656e-03	2.922
Signaling by SCF-KIT	R-HSA-1433557	1.348344e-03	2.870
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.352362e-03	2.869
Telomere Maintenance	R-HSA-157579	1.388814e-03	2.857
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.388814e-03	2.857
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.393878e-03	2.856
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.393878e-03	2.856
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.393878e-03	2.856
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.393878e-03	2.856
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.393878e-03	2.856
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.393878e-03	2.856
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.393878e-03	2.856
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.393878e-03	2.856
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.393878e-03	2.856
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.393878e-03	2.856
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.393878e-03	2.856
Transcriptional Regulation by TP53	R-HSA-3700989	1.396867e-03	2.855
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.405145e-03	2.852
Stabilization of p53	R-HSA-69541	1.405145e-03	2.852
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.428496e-03	2.845
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.435853e-03	2.843
FLT3 signaling by CBL mutants	R-HSA-9706377	1.581976e-03	2.801
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.630685e-03	2.788
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.787400e-03	2.748
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.787400e-03	2.748
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	1.767932e-03	2.753
Myogenesis	R-HSA-525793	1.748803e-03	2.757
Asymmetric localization of PCP proteins	R-HSA-4608870	1.941750e-03	2.712
Regulation of Apoptosis	R-HSA-169911	1.767932e-03	2.753
Platelet degranulation	R-HSA-114608	1.977612e-03	2.704
Negative regulation of NOTCH4 signaling	R-HSA-9604323	1.708306e-03	2.767
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.779969e-03	2.750
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.051640e-03	2.688
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	2.072497e-03	2.684
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.138092e-03	2.670
Spry regulation of FGF signaling	R-HSA-1295596	2.138092e-03	2.670
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.151404e-03	2.667
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	2.267814e-03	2.644
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	2.267814e-03	2.644
Mitotic Telophase/Cytokinesis	R-HSA-68884	2.267814e-03	2.644
Transcriptional Regulation by MECP2	R-HSA-8986944	2.274193e-03	2.643
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	2.311640e-03	2.636
Glucose metabolism	R-HSA-70326	2.329517e-03	2.633
Cilium Assembly	R-HSA-5617833	2.377641e-03	2.624
Degradation of GLI1 by the proteasome	R-HSA-5610780	2.478727e-03	2.606
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.511127e-03	2.600
COPI-mediated anterograde transport	R-HSA-6807878	2.539316e-03	2.595
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.623316e-03	2.581
IPs transport between nucleus and cytosol	R-HSA-1855170	2.727878e-03	2.564
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.727878e-03	2.564
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	2.738107e-03	2.563
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.803563e-03	2.552
Transcriptional regulation by RUNX2	R-HSA-8878166	2.862963e-03	2.543
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.913420e-03	2.536
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.941496e-03	2.531
MTOR signalling	R-HSA-165159	2.959842e-03	2.529
Metabolism of non-coding RNA	R-HSA-194441	3.093586e-03	2.510
snRNP Assembly	R-HSA-191859	3.093586e-03	2.510
Late Phase of HIV Life Cycle	R-HSA-162599	3.253013e-03	2.488
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	3.266874e-03	2.486
Co-inhibition by CTLA4	R-HSA-389513	3.281437e-03	2.484
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.288668e-03	2.483
DNA Repair	R-HSA-73894	3.324802e-03	2.478
Vpu mediated degradation of CD4	R-HSA-180534	3.330180e-03	2.478
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	3.330180e-03	2.478
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	3.431118e-03	2.465
Regulation of PTEN gene transcription	R-HSA-8943724	3.577468e-03	2.446
p53-Dependent G1 DNA Damage Response	R-HSA-69563	3.786513e-03	2.422
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	3.786513e-03	2.422
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	3.790866e-03	2.421
Transcriptional Regulation by E2F6	R-HSA-8953750	3.790866e-03	2.421
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	3.891911e-03	2.410
Signaling by Nuclear Receptors	R-HSA-9006931	3.938704e-03	2.405
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	3.985941e-03	2.399
Signaling by NOTCH3	R-HSA-9012852	3.985941e-03	2.399
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	4.035549e-03	2.394
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	4.035549e-03	2.394
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	4.152125e-03	2.382
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	4.152125e-03	2.382
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.218410e-03	2.375
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.218410e-03	2.375
Activation of BH3-only proteins	R-HSA-114452	4.219692e-03	2.375
Sema4D in semaphorin signaling	R-HSA-400685	4.300714e-03	2.366
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	4.593668e-03	2.338
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	4.612235e-03	2.336
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	4.612235e-03	2.336
Pre-NOTCH Transcription and Translation	R-HSA-1912408	4.644876e-03	2.333
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	4.822486e-03	2.317
MET activates RAP1 and RAC1	R-HSA-8875555	4.822486e-03	2.317
Josephin domain DUBs	R-HSA-5689877	4.822486e-03	2.317
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	4.856097e-03	2.314
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	4.856097e-03	2.314
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	4.879970e-03	2.312
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	4.879970e-03	2.312
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	6.033054e-03	2.219
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	5.106422e-03	2.292
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	5.352032e-03	2.271
Signaling by KIT in disease	R-HSA-9669938	6.708045e-03	2.173
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	6.708045e-03	2.173
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	6.643948e-03	2.178
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	5.954426e-03	2.225
VEGFR2 mediated vascular permeability	R-HSA-5218920	5.347225e-03	2.272
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.185486e-03	2.209
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.347225e-03	2.272
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	5.352032e-03	2.271
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.030392e-03	2.220
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	6.663507e-03	2.176
Activation of HOX genes during differentiation	R-HSA-5619507	6.663507e-03	2.176
Hh mutants are degraded by ERAD	R-HSA-5362768	5.347225e-03	2.272
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	6.297461e-03	2.201
Degradation of GLI2 by the proteasome	R-HSA-5610783	6.297461e-03	2.201
Generic Transcription Pathway	R-HSA-212436	5.225313e-03	2.282
Vif-mediated degradation of APOBEC3G	R-HSA-180585	5.804553e-03	2.236
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	5.352032e-03	2.271
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	5.352032e-03	2.271
G1/S DNA Damage Checkpoints	R-HSA-69615	5.416519e-03	2.266
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	5.707454e-03	2.244
Signaling by Hedgehog	R-HSA-5358351	6.625919e-03	2.179
FLT3 Signaling	R-HSA-9607240	5.347225e-03	2.272
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.894196e-03	2.162
Degradation of AXIN	R-HSA-4641257	6.894196e-03	2.162
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	6.894196e-03	2.162
Regulation of PTEN localization	R-HSA-8948747	7.075747e-03	2.150
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	7.350373e-03	2.134
Vesicle-mediated transport	R-HSA-5653656	7.367117e-03	2.133
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	7.377327e-03	2.132
Co-stimulation by CD28	R-HSA-389356	7.699180e-03	2.114
Base-Excision Repair, AP Site Formation	R-HSA-73929	7.887740e-03	2.103
AURKA Activation by TPX2	R-HSA-8854518	7.961334e-03	2.099
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	7.979653e-03	2.098
DCC mediated attractive signaling	R-HSA-418885	7.979653e-03	2.098
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	8.209086e-03	2.086
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.598505e-03	2.066
ER to Golgi Anterograde Transport	R-HSA-199977	8.698404e-03	2.061
Negative regulation of the PI3K/AKT network	R-HSA-199418	8.722102e-03	2.059
PI3K/AKT Signaling in Cancer	R-HSA-2219528	8.866425e-03	2.052
Synthesis of DNA	R-HSA-69239	8.898629e-03	2.051
MAP kinase activation	R-HSA-450294	9.055877e-03	2.043
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.055877e-03	2.043
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	9.372568e-03	2.028
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	9.696036e-03	2.013
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	9.930692e-03	2.003
Cyclin D associated events in G1	R-HSA-69231	9.972998e-03	2.001
G1 Phase	R-HSA-69236	9.972998e-03	2.001
RMTs methylate histone arginines	R-HSA-3214858	9.972998e-03	2.001
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.019403e-02	1.992
Regulation of RAS by GAPs	R-HSA-5658442	1.020629e-02	1.991
tRNA processing in the nucleus	R-HSA-6784531	1.025871e-02	1.989
Signaling by EGFR	R-HSA-177929	1.029085e-02	1.988
Prolonged ERK activation events	R-HSA-169893	1.035373e-02	1.985
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	1.035373e-02	1.985
Negative regulation of FLT3	R-HSA-9706369	1.035373e-02	1.985
Formation of annular gap junctions	R-HSA-196025	1.036817e-02	1.984
RAF activation	R-HSA-5673000	1.053627e-02	1.977
TP53 Regulates Metabolic Genes	R-HSA-5628897	1.112627e-02	1.954
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.150464e-02	1.939
Defective CFTR causes cystic fibrosis	R-HSA-5678895	1.151306e-02	1.939
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.151306e-02	1.939
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.158450e-02	1.936
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.158450e-02	1.936
Activation of NF-kappaB in B cells	R-HSA-1169091	1.167900e-02	1.933
Hedgehog ligand biogenesis	R-HSA-5358346	1.167900e-02	1.933
MyD88-independent TLR4 cascade	R-HSA-166166	1.170950e-02	1.931
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.170950e-02	1.931
PERK regulates gene expression	R-HSA-381042	1.239394e-02	1.907
Signalling to ERKs	R-HSA-187687	1.239394e-02	1.907
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.253306e-02	1.902
VLDLR internalisation and degradation	R-HSA-8866427	1.253306e-02	1.902
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.275825e-02	1.894
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.275825e-02	1.894
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.294514e-02	1.888
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	1.294514e-02	1.888
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.320385e-02	1.879
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.323114e-02	1.878
Developmental Cell Lineages	R-HSA-9734767	1.329360e-02	1.876
Nucleotide Excision Repair	R-HSA-5696398	1.346776e-02	1.871
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	1.366634e-02	1.864
Trafficking of AMPA receptors	R-HSA-399719	1.366634e-02	1.864
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.366634e-02	1.864
Signaling by TGFB family members	R-HSA-9006936	1.383656e-02	1.859
ER-Phagosome pathway	R-HSA-1236974	1.414531e-02	1.849
GP1b-IX-V activation signalling	R-HSA-430116	1.457993e-02	1.836
Gap junction degradation	R-HSA-190873	1.457993e-02	1.836
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	1.457993e-02	1.836
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.457993e-02	1.836
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	1.473282e-02	1.832
Signaling by EGFR in Cancer	R-HSA-1643713	1.489331e-02	1.827
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.489331e-02	1.827
Metalloprotease DUBs	R-HSA-5689901	1.489331e-02	1.827
Negative regulation of MAPK pathway	R-HSA-5675221	1.495358e-02	1.825
Degradation of CRY and PER proteins	R-HSA-9932298	1.495358e-02	1.825
Pre-NOTCH Expression and Processing	R-HSA-1912422	1.519426e-02	1.818
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.547050e-02	1.810
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	1.547050e-02	1.810
Maturation of protein E	R-HSA-9683683	1.547050e-02	1.810
Maturation of protein E	R-HSA-9694493	1.547050e-02	1.810
Downstream TCR signaling	R-HSA-202424	1.557931e-02	1.807
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.594229e-02	1.797
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.594229e-02	1.797
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.611863e-02	1.793
Reproduction	R-HSA-1474165	1.625661e-02	1.789
Frs2-mediated activation	R-HSA-170968	1.637484e-02	1.786
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.637484e-02	1.786
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.637484e-02	1.786
Cellular responses to mechanical stimuli	R-HSA-9855142	1.652331e-02	1.782
Ovarian tumor domain proteases	R-HSA-5689896	1.684382e-02	1.774
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.725153e-02	1.763
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	2.361074e-02	1.627
MET interacts with TNS proteins	R-HSA-8875513	2.184463e-02	1.661
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	2.184463e-02	1.661
Signaling by LTK in cancer	R-HSA-9842640	2.263892e-02	1.645
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.506706e-02	1.601
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	1.930860e-02	1.714
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.468488e-02	1.608
Integrin signaling	R-HSA-354192	1.888280e-02	1.724
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.888280e-02	1.724
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.197965e-02	1.658
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	2.542924e-02	1.595
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	2.542924e-02	1.595
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	2.166362e-02	1.664
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.765765e-02	1.753
Centrosome maturation	R-HSA-380287	2.165466e-02	1.664
Translesion Synthesis by POLH	R-HSA-110320	2.506706e-02	1.601
Rap1 signalling	R-HSA-392517	2.506706e-02	1.601
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.310535e-02	1.636
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.095983e-02	1.679
Response of endothelial cells to shear stress	R-HSA-9860931	2.012130e-02	1.696
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.930860e-02	1.714
Adaptive Immune System	R-HSA-1280218	1.783122e-02	1.749
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.966842e-02	1.706
Interleukin-17 signaling	R-HSA-448424	2.500158e-02	1.602
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	2.493004e-02	1.603
Negative regulation of FGFR3 signaling	R-HSA-5654732	2.102108e-02	1.677
Negative regulation of FGFR4 signaling	R-HSA-5654733	2.468488e-02	1.608
Viral Messenger RNA Synthesis	R-HSA-168325	1.883395e-02	1.725
rRNA modification in the nucleus and cytosol	R-HSA-6790901	2.346295e-02	1.630
Hemostasis	R-HSA-109582	1.981135e-02	1.703
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.980720e-02	1.703
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.974135e-02	1.705
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.888280e-02	1.724
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.034611e-02	1.692
Signaling by NTRKs	R-HSA-166520	2.539603e-02	1.595
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	2.613083e-02	1.583
Disease	R-HSA-1643685	1.755389e-02	1.756
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.095983e-02	1.679
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.888280e-02	1.724
Response of Mtb to phagocytosis	R-HSA-9637690	1.966842e-02	1.706
Non-integrin membrane-ECM interactions	R-HSA-3000171	2.165466e-02	1.664
ABC-family proteins mediated transport	R-HSA-382556	2.520228e-02	1.599
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.166362e-02	1.664
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	2.541041e-02	1.595
XBP1(S) activates chaperone genes	R-HSA-381038	1.974135e-02	1.705
IRE1alpha activates chaperones	R-HSA-381070	1.878788e-02	1.726
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	2.634318e-02	1.579
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.634318e-02	1.579
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	2.634318e-02	1.579
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.750590e-02	1.561
Deadenylation of mRNA	R-HSA-429947	2.750590e-02	1.561
Metabolism of proteins	R-HSA-392499	2.762550e-02	1.559
Base Excision Repair	R-HSA-73884	2.830843e-02	1.548
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.878048e-02	1.541
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	2.878048e-02	1.541
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	2.889433e-02	1.539
PKMTs methylate histone lysines	R-HSA-3214841	2.916649e-02	1.535
Transcriptional Regulation by VENTX	R-HSA-8853884	2.916649e-02	1.535
Negative regulation of MET activity	R-HSA-6807004	3.026251e-02	1.519
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	3.026251e-02	1.519
trans-Golgi Network Vesicle Budding	R-HSA-199992	3.041331e-02	1.517
Golgi-to-ER retrograde transport	R-HSA-8856688	3.099613e-02	1.509
Golgi Associated Vesicle Biogenesis	R-HSA-432722	3.128892e-02	1.505
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.153656e-02	1.501
IFNG signaling activates MAPKs	R-HSA-9732724	3.153656e-02	1.501
Sensory processing of sound	R-HSA-9659379	3.166819e-02	1.499
SWI/SNF chromatin remodelers	R-HSA-9932451	3.239485e-02	1.490
ATP-dependent chromatin remodelers	R-HSA-9932444	3.239485e-02	1.490
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	3.257223e-02	1.487
Regulation of BACH1 activity	R-HSA-9708530	3.257223e-02	1.487
EGFR downregulation	R-HSA-182971	3.332980e-02	1.477
Evasion by RSV of host interferon responses	R-HSA-9833109	3.332980e-02	1.477
RET signaling	R-HSA-8853659	3.346207e-02	1.475
Condensation of Prometaphase Chromosomes	R-HSA-2514853	3.361462e-02	1.473
Integration of provirus	R-HSA-162592	3.361462e-02	1.473
Cytochrome c-mediated apoptotic response	R-HSA-111461	3.361462e-02	1.473
Signaling by FGFR2	R-HSA-5654738	3.463394e-02	1.460
Regulation of gap junction activity	R-HSA-191650	3.467268e-02	1.460
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	3.467268e-02	1.460
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	3.467268e-02	1.460
Signaling by MAP2K mutants	R-HSA-9652169	3.467268e-02	1.460
FLT3 signaling through SRC family kinases	R-HSA-9706374	3.467268e-02	1.460
AKT-mediated inactivation of FOXO1A	R-HSA-211163	3.467268e-02	1.460
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.548410e-02	1.450
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.613671e-02	1.442
Intraflagellar transport	R-HSA-5620924	3.618947e-02	1.441
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	3.624721e-02	1.441
Ca-dependent events	R-HSA-111996	3.729865e-02	1.428
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.784474e-02	1.422
MHC class II antigen presentation	R-HSA-2132295	3.796310e-02	1.421
G0 and Early G1	R-HSA-1538133	3.835280e-02	1.416
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	3.968566e-02	1.401
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	4.008457e-02	1.397
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.221869e-02	1.374
Myoclonic epilepsy of Lafora	R-HSA-3785653	4.221869e-02	1.374
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	4.221869e-02	1.374
Modulation by Mtb of host immune system	R-HSA-9637628	4.221869e-02	1.374
AKT phosphorylates targets in the cytosol	R-HSA-198323	4.230444e-02	1.374
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	4.230444e-02	1.374
p75NTR recruits signalling complexes	R-HSA-209543	4.230444e-02	1.374
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	4.271732e-02	1.369
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	4.271732e-02	1.369
Signaling by PDGFR in disease	R-HSA-9671555	4.271732e-02	1.369
Ion homeostasis	R-HSA-5578775	4.291054e-02	1.367
MET promotes cell motility	R-HSA-8875878	4.311968e-02	1.365
Regulation of necroptotic cell death	R-HSA-5675482	4.386734e-02	1.358
Negative regulation of FGFR1 signaling	R-HSA-5654726	4.386734e-02	1.358
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	4.387721e-02	1.358
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.387721e-02	1.358
Interaction between L1 and Ankyrins	R-HSA-445095	4.387721e-02	1.358
Interleukin-1 signaling	R-HSA-9020702	4.636115e-02	1.334
Proteasome assembly	R-HSA-9907900	4.689600e-02	1.329
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	4.854454e-02	1.314
Manipulation of host energy metabolism	R-HSA-9636667	4.922328e-02	1.308
Breakdown of the nuclear lamina	R-HSA-352238	4.922328e-02	1.308
FGFR2 alternative splicing	R-HSA-6803529	5.002652e-02	1.301
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	5.002652e-02	1.301
HIV elongation arrest and recovery	R-HSA-167287	5.051038e-02	1.297
Pausing and recovery of HIV elongation	R-HSA-167290	5.051038e-02	1.297
Nectin/Necl trans heterodimerization	R-HSA-420597	5.060288e-02	1.296
NrCAM interactions	R-HSA-447038	5.060288e-02	1.296
Dual incision in TC-NER	R-HSA-6782135	5.216095e-02	1.283
Platelet Adhesion to exposed collagen	R-HSA-75892	5.222793e-02	1.282
CD28 dependent Vav1 pathway	R-HSA-389359	5.222793e-02	1.282
Membrane binding and targetting of GAG proteins	R-HSA-174490	5.222793e-02	1.282
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	5.222793e-02	1.282
DAG and IP3 signaling	R-HSA-1489509	5.227340e-02	1.282
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	5.227340e-02	1.282
Somitogenesis	R-HSA-9824272	5.227340e-02	1.282
CLEC7A (Dectin-1) signaling	R-HSA-5607764	5.338672e-02	1.273
Cellular response to hypoxia	R-HSA-1234174	5.391829e-02	1.268
Generation of second messenger molecules	R-HSA-202433	5.451674e-02	1.263
Glycogen metabolism	R-HSA-8982491	5.451674e-02	1.263
AKT phosphorylates targets in the nucleus	R-HSA-198693	5.469821e-02	1.262
Inactivation of CDC42 and RAC1	R-HSA-428543	5.469821e-02	1.262
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	5.469821e-02	1.262
Unwinding of DNA	R-HSA-176974	5.469821e-02	1.262
Cellular response to mitochondrial stress	R-HSA-9840373	5.469821e-02	1.262
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.510797e-02	1.259
Transcriptional Regulation by NPAS4	R-HSA-9634815	5.510797e-02	1.259
Transmission across Chemical Synapses	R-HSA-112315	5.577116e-02	1.254
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.643037e-02	1.248
NPAS4 regulates expression of target genes	R-HSA-9768919	5.643037e-02	1.248
Signaling by ERBB2 ECD mutants	R-HSA-9665348	5.667392e-02	1.247
Apoptotic factor-mediated response	R-HSA-111471	5.667392e-02	1.247
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	5.667392e-02	1.247
Regulation of TP53 Activity through Methylation	R-HSA-6804760	5.667392e-02	1.247
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	5.680992e-02	1.246
Late endosomal microautophagy	R-HSA-9615710	5.775870e-02	1.238
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	5.775870e-02	1.238
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.775870e-02	1.238
Regulation of TNFR1 signaling	R-HSA-5357905	5.804956e-02	1.236
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	5.808080e-02	1.236
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.808080e-02	1.236
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	5.808080e-02	1.236
Growth hormone receptor signaling	R-HSA-982772	5.808080e-02	1.236
Signaling by MET	R-HSA-6806834	6.080402e-02	1.216
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.083519e-02	1.216
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.155029e-02	1.211
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.155029e-02	1.211
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.155029e-02	1.211
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.339481e-02	1.198
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	6.339481e-02	1.198
NRIF signals cell death from the nucleus	R-HSA-205043	6.339481e-02	1.198
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	6.350210e-02	1.197
IKK complex recruitment mediated by RIP1	R-HSA-937041	6.657888e-02	1.177
HCMV Late Events	R-HSA-9610379	6.677906e-02	1.175
CD209 (DC-SIGN) signaling	R-HSA-5621575	6.689072e-02	1.175
Potential therapeutics for SARS	R-HSA-9679191	6.791577e-02	1.168
Formation of paraxial mesoderm	R-HSA-9793380	6.844777e-02	1.165
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	6.894992e-02	1.161
2-LTR circle formation	R-HSA-164843	6.894992e-02	1.161
Formation of apoptosome	R-HSA-111458	6.894992e-02	1.161
Regulation of CDH11 function	R-HSA-9762292	6.894992e-02	1.161
Regulation of the apoptosome activity	R-HSA-9627069	6.894992e-02	1.161
Signal attenuation	R-HSA-74749	6.894992e-02	1.161
Pexophagy	R-HSA-9664873	6.894992e-02	1.161
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	6.946267e-02	1.158
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.946267e-02	1.158
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.946267e-02	1.158
Regulation of CDH19 Expression and Function	R-HSA-9764302	6.946267e-02	1.158
Innate Immune System	R-HSA-168249	6.974085e-02	1.157
Gluconeogenesis	R-HSA-70263	7.082820e-02	1.150
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.084272e-02	1.150
Calmodulin induced events	R-HSA-111933	7.111156e-02	1.148
GPVI-mediated activation cascade	R-HSA-114604	7.111156e-02	1.148
CaM pathway	R-HSA-111997	7.111156e-02	1.148
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.215806e-02	1.142
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.215806e-02	1.142
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.215806e-02	1.142
RNA Polymerase I Transcription Initiation	R-HSA-73762	7.505391e-02	1.125
IRF3-mediated induction of type I IFN	R-HSA-3270619	7.579770e-02	1.120
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	7.579770e-02	1.120
ERBB2 Regulates Cell Motility	R-HSA-6785631	7.579770e-02	1.120
Translesion synthesis by REV1	R-HSA-110312	7.579770e-02	1.120
Protein methylation	R-HSA-8876725	7.579770e-02	1.120
p75NTR signals via NF-kB	R-HSA-193639	7.579770e-02	1.120
Formation of definitive endoderm	R-HSA-9823730	7.742849e-02	1.111
DNA Damage Bypass	R-HSA-73893	7.784175e-02	1.109
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	7.784175e-02	1.109
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.954216e-02	1.099
Antigen processing-Cross presentation	R-HSA-1236975	7.954216e-02	1.099
TNF signaling	R-HSA-75893	7.974973e-02	1.098
Detoxification of Reactive Oxygen Species	R-HSA-3299685	7.974973e-02	1.098
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	8.114688e-02	1.091
Diseases of Cellular Senescence	R-HSA-9630747	8.114688e-02	1.091
Diseases of cellular response to stress	R-HSA-9675132	8.114688e-02	1.091
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	8.114688e-02	1.091
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	8.114688e-02	1.091
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	8.114688e-02	1.091
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	R-HSA-1299308	8.114688e-02	1.091
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	R-HSA-180897	8.114688e-02	1.091
Signaling by FGFR4	R-HSA-5654743	8.284250e-02	1.082
Diseases of mitotic cell cycle	R-HSA-9675126	8.328010e-02	1.079
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.328010e-02	1.079
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	8.344671e-02	1.079
Drug resistance of KIT mutants	R-HSA-9669937	1.108019e-01	0.955
KIT mutants bind TKIs	R-HSA-9669921	1.108019e-01	0.955
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.108019e-01	0.955
Evasion of Oncogene Induced Senescence Due to p14ARF Defects	R-HSA-9646303	1.108019e-01	0.955
Sunitinib-resistant KIT mutants	R-HSA-9669934	1.108019e-01	0.955
Sorafenib-resistant KIT mutants	R-HSA-9669936	1.108019e-01	0.955
Regorafenib-resistant KIT mutants	R-HSA-9669929	1.108019e-01	0.955
Masitinib-resistant KIT mutants	R-HSA-9669924	1.108019e-01	0.955
Imatinib-resistant KIT mutants	R-HSA-9669917	1.108019e-01	0.955
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	R-HSA-9646304	1.108019e-01	0.955
Nilotinib-resistant KIT mutants	R-HSA-9669926	1.108019e-01	0.955
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	1.108019e-01	0.955
Dasatinib-resistant KIT mutants	R-HSA-9669914	1.108019e-01	0.955
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.176700e-01	0.929
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.176700e-01	0.929
MET activates PTPN11	R-HSA-8865999	1.176700e-01	0.929
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.573826e-01	0.803
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.573826e-01	0.803
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.573826e-01	0.803
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	1.573826e-01	0.803
NOSTRIN mediated eNOS trafficking	R-HSA-203641	1.149365e-01	0.940
Recycling of eIF2:GDP	R-HSA-72731	1.149365e-01	0.940
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.149365e-01	0.940
Activated NTRK2 signals through FYN	R-HSA-9032500	1.409356e-01	0.851
Type I hemidesmosome assembly	R-HSA-446107	1.409356e-01	0.851
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	1.409356e-01	0.851
Signaling by MRAS-complex mutants	R-HSA-9660537	1.409356e-01	0.851
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.409356e-01	0.851
Translesion synthesis by POLI	R-HSA-5656121	8.941317e-02	1.049
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	8.941317e-02	1.049
Regulation of IFNG signaling	R-HSA-877312	1.216189e-01	0.915
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.216189e-01	0.915
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.686712e-01	0.773
ARMS-mediated activation	R-HSA-170984	1.686712e-01	0.773
Lipophagy	R-HSA-9613354	1.686712e-01	0.773
WNT mediated activation of DVL	R-HSA-201688	1.686712e-01	0.773
Calcineurin activates NFAT	R-HSA-2025928	1.686712e-01	0.773
ALK mutants bind TKIs	R-HSA-9700645	1.686712e-01	0.773
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.042032e-01	0.982
GRB2 events in ERBB2 signaling	R-HSA-1963640	1.042032e-01	0.982
Translesion synthesis by POLK	R-HSA-5655862	1.042032e-01	0.982
ERK/MAPK targets	R-HSA-198753	8.921418e-02	1.050
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.201168e-01	0.920
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.201168e-01	0.920
PI3K events in ERBB2 signaling	R-HSA-1963642	1.201168e-01	0.920
GAB1 signalosome	R-HSA-180292	1.370916e-01	0.863
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	9.787123e-02	1.009
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	9.787123e-02	1.009
Signaling by CSF3 (G-CSF)	R-HSA-9674555	1.222331e-01	0.913
Dual Incision in GG-NER	R-HSA-5696400	1.144781e-01	0.941
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.354728e-01	0.868
Nuclear signaling by ERBB4	R-HSA-1251985	1.069765e-01	0.971
Signaling by ERBB4	R-HSA-1236394	1.094817e-01	0.961
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	1.267976e-01	0.897
Post-translational protein phosphorylation	R-HSA-8957275	9.814542e-02	1.008
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.481385e-01	0.829
Early Phase of HIV Life Cycle	R-HSA-162594	8.921418e-02	1.050
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.795943e-02	1.056
Platelet Aggregation (Plug Formation)	R-HSA-76009	9.984605e-02	1.001
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.299732e-01	0.886
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.452501e-01	0.838
Activation of the pre-replicative complex	R-HSA-68962	1.354728e-01	0.868
Interferon alpha/beta signaling	R-HSA-909733	8.848539e-02	1.053
TGFBR3 expression	R-HSA-9839394	1.613007e-01	0.792
MicroRNA (miRNA) biogenesis	R-HSA-203927	1.613007e-01	0.792
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.941317e-02	1.049
CD28 dependent PI3K/Akt signaling	R-HSA-389357	9.787123e-02	1.009
RUNX3 regulates p14-ARF	R-HSA-8951936	1.216189e-01	0.915
E2F mediated regulation of DNA replication	R-HSA-113510	1.550556e-01	0.810
NADE modulates death signalling	R-HSA-205025	1.573826e-01	0.803
Adrenoceptors	R-HSA-390696	1.409356e-01	0.851
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	1.216189e-01	0.915
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	8.921418e-02	1.050
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	1.638728e-01	0.785
Platelet sensitization by LDL	R-HSA-432142	1.370916e-01	0.863
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	1.611468e-01	0.793
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	1.686712e-01	0.773
Glycogen breakdown (glycogenolysis)	R-HSA-70221	1.613007e-01	0.792
Signaling by NOTCH1	R-HSA-1980143	1.252673e-01	0.902
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	1.611468e-01	0.793
Mitophagy	R-HSA-5205647	1.144781e-01	0.941
CHL1 interactions	R-HSA-447041	1.149365e-01	0.940
Basigin interactions	R-HSA-210991	8.921418e-02	1.050
Post-translational protein modification	R-HSA-597592	1.427286e-01	0.845
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	9.305459e-02	1.031
C-type lectin receptors (CLRs)	R-HSA-5621481	1.357202e-01	0.867
Suppression of apoptosis	R-HSA-9635465	8.491539e-02	1.071
ROBO receptors bind AKAP5	R-HSA-9010642	1.409356e-01	0.851
Malate-aspartate shuttle	R-HSA-9856872	1.638728e-01	0.785
PLC beta mediated events	R-HSA-112043	1.190195e-01	0.924
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.270639e-01	0.896
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	1.042032e-01	0.982
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	1.550556e-01	0.810
Signaling by FGFR	R-HSA-190236	9.814542e-02	1.008
Signaling by FGFR3	R-HSA-5654741	9.984605e-02	1.001
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.176700e-01	0.929
MTF1 activates gene expression	R-HSA-5660489	1.573826e-01	0.803
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	1.216189e-01	0.915
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	1.096915e-01	0.960
NOD1/2 Signaling Pathway	R-HSA-168638	1.144781e-01	0.941
Signaling by FGFR1	R-HSA-5654736	1.386790e-01	0.858
Circadian clock	R-HSA-9909396	1.597219e-01	0.797
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	8.679013e-02	1.062
Ion transport by P-type ATPases	R-HSA-936837	8.775651e-02	1.057
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.020582e-01	0.991
Mitochondrial biogenesis	R-HSA-1592230	9.914879e-02	1.004
Netrin-1 signaling	R-HSA-373752	9.110679e-02	1.040
MyD88 dependent cascade initiated on endosome	R-HSA-975155	8.457973e-02	1.073
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	1.686712e-01	0.773
Uptake and function of diphtheria toxin	R-HSA-5336415	1.149365e-01	0.940
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.409356e-01	0.851
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	1.067947e-01	0.971
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	9.494953e-02	1.023
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	1.216189e-01	0.915
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	1.216189e-01	0.915
Syndecan interactions	R-HSA-3000170	1.299732e-01	0.886
STING mediated induction of host immune responses	R-HSA-1834941	1.550556e-01	0.810
Assembly Of The HIV Virion	R-HSA-175474	1.019186e-01	0.992
Signal regulatory protein family interactions	R-HSA-391160	1.638728e-01	0.785
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.719846e-02	1.012
Regulation of NF-kappa B signaling	R-HSA-9758274	8.941317e-02	1.049
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	8.921418e-02	1.050
NF-kB is activated and signals survival	R-HSA-209560	1.025081e-01	0.989
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.216189e-01	0.915
IRAK1 recruits IKK complex	R-HSA-937039	1.216189e-01	0.915
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	8.921418e-02	1.050
Activation of ATR in response to replication stress	R-HSA-176187	9.305459e-02	1.031
Interleukin-1 family signaling	R-HSA-446652	1.093781e-01	0.961
Hedgehog 'on' state	R-HSA-5632684	8.815606e-02	1.055
Regulation of gene expression in beta cells	R-HSA-210745	1.222331e-01	0.913
Formation of RNA Pol II elongation complex	R-HSA-112382	1.738131e-01	0.760
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	1.739292e-01	0.760
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.739292e-01	0.760
Protein hydroxylation	R-HSA-9629569	1.739292e-01	0.760
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	1.739292e-01	0.760
Glycogen synthesis	R-HSA-3322077	1.739292e-01	0.760
Suppression of phagosomal maturation	R-HSA-9637687	1.780734e-01	0.749
G-protein mediated events	R-HSA-112040	1.782369e-01	0.749
Signaling by ALK	R-HSA-201556	1.782888e-01	0.749
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.797799e-01	0.745
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.822401e-01	0.739
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.822401e-01	0.739
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.822401e-01	0.739
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.822401e-01	0.739
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.822401e-01	0.739
Transport to the Golgi and subsequent modification	R-HSA-948021	1.824737e-01	0.739
Iron uptake and transport	R-HSA-917937	1.845511e-01	0.734
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	1.848138e-01	0.733
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	1.848138e-01	0.733
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.860747e-01	0.730
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	1.867266e-01	0.729
p38MAPK events	R-HSA-171007	1.867266e-01	0.729
Regulated Necrosis	R-HSA-5218859	1.892882e-01	0.723
mRNA Splicing - Minor Pathway	R-HSA-72165	1.896085e-01	0.722
Signaling by TGFBR3	R-HSA-9839373	1.896085e-01	0.722
Regulation of pyruvate metabolism	R-HSA-9861718	1.896085e-01	0.722
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.926325e-01	0.715
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.926325e-01	0.715
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	1.936264e-01	0.713
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.936264e-01	0.713
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.948015e-01	0.710
Cristae formation	R-HSA-8949613	1.955127e-01	0.709
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.955127e-01	0.709
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.955127e-01	0.709
MAPK3 (ERK1) activation	R-HSA-110056	1.978134e-01	0.704
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	1.978134e-01	0.704
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	1.978134e-01	0.704
PI3K/AKT activation	R-HSA-198203	1.978134e-01	0.704
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	1.991304e-01	0.701
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	1.991304e-01	0.701
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	1.991304e-01	0.701
Co-inhibition by BTLA	R-HSA-9927353	1.991304e-01	0.701
IRS activation	R-HSA-74713	1.991304e-01	0.701
Post-transcriptional silencing by small RNAs	R-HSA-426496	1.991304e-01	0.701
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.991304e-01	0.701
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.991304e-01	0.701
NTRK2 activates RAC1	R-HSA-9032759	1.991304e-01	0.701
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	1.991304e-01	0.701
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	1.991304e-01	0.701
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	1.991304e-01	0.701
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	1.991304e-01	0.701
SMAC (DIABLO) binds to IAPs	R-HSA-111463	1.991304e-01	0.701
Opioid Signalling	R-HSA-111885	2.021087e-01	0.694
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.074377e-01	0.683
Diseases of Telomere Maintenance	R-HSA-9673013	2.093324e-01	0.679
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.093324e-01	0.679
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.093324e-01	0.679
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.093324e-01	0.679
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	2.093324e-01	0.679
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.093324e-01	0.679
TICAM1 deficiency - HSE	R-HSA-5602566	2.093324e-01	0.679
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	2.093324e-01	0.679
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.093324e-01	0.679
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.093324e-01	0.679
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9632697	2.093324e-01	0.679
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9630791	2.093324e-01	0.679
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	2.093324e-01	0.679
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	2.093324e-01	0.679
Defective F8 binding to von Willebrand factor	R-HSA-9672393	2.093324e-01	0.679
Hereditary fructose intolerance	R-HSA-5657560	2.093324e-01	0.679
SARS-CoV-1 targets PDZ proteins in cell-cell junction	R-HSA-9692912	2.093324e-01	0.679
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.093324e-01	0.679
Inhibition of PKR	R-HSA-169131	2.093324e-01	0.679
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	2.105278e-01	0.677
Signaling by NOTCH2	R-HSA-1980145	2.110410e-01	0.676
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	2.135591e-01	0.670
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	2.135591e-01	0.670
Toll-like Receptor Cascades	R-HSA-168898	2.142643e-01	0.669
Nuclear Receptor transcription pathway	R-HSA-383280	2.174367e-01	0.663
ABC transporter disorders	R-HSA-5619084	2.174367e-01	0.663
Death Receptor Signaling	R-HSA-73887	2.249208e-01	0.648
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	2.280426e-01	0.642
p75 NTR receptor-mediated signalling	R-HSA-193704	2.285135e-01	0.641
FOXO-mediated transcription	R-HSA-9614085	2.285135e-01	0.641
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	2.313186e-01	0.636
Termination of translesion DNA synthesis	R-HSA-5656169	2.321508e-01	0.634
Platelet calcium homeostasis	R-HSA-418360	2.321508e-01	0.634
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.351205e-01	0.629
Disorders of Developmental Biology	R-HSA-9675151	2.351205e-01	0.629
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.351205e-01	0.629
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	2.351205e-01	0.629
RAF-independent MAPK1/3 activation	R-HSA-112409	2.351278e-01	0.629
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.406457e-01	0.619
Noncanonical activation of NOTCH3	R-HSA-9017802	2.419754e-01	0.616
Phosphorylation of Emi1	R-HSA-176417	2.419754e-01	0.616
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.419754e-01	0.616
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.419754e-01	0.616
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	2.419754e-01	0.616
Sodium-coupled phosphate cotransporters	R-HSA-427652	2.419754e-01	0.616
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	2.431868e-01	0.614
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	2.438337e-01	0.613
Pyruvate metabolism	R-HSA-70268	2.441306e-01	0.612
Lysosome Vesicle Biogenesis	R-HSA-432720	2.449103e-01	0.611
RUNX2 regulates bone development	R-HSA-8941326	2.449103e-01	0.611
Interleukin-37 signaling	R-HSA-9008059	2.512236e-01	0.600
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	2.583551e-01	0.588
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	2.590560e-01	0.587
ERKs are inactivated	R-HSA-202670	2.590560e-01	0.587
Signaling by AMER1 mutants	R-HSA-4839748	2.590560e-01	0.587
Signaling by GSK3beta mutants	R-HSA-5339716	2.590560e-01	0.587
Reduction of cytosolic Ca++ levels	R-HSA-418359	2.590560e-01	0.587
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	2.590560e-01	0.587
Activation of RAC1	R-HSA-428540	2.590560e-01	0.587
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	2.603498e-01	0.584
Regulation of FZD by ubiquitination	R-HSA-4641263	2.603498e-01	0.584
Glycogen storage diseases	R-HSA-3229121	2.603498e-01	0.584
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.615669e-01	0.582
Budding and maturation of HIV virion	R-HSA-162588	2.707125e-01	0.567
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	2.753076e-01	0.560
Uptake and actions of bacterial toxins	R-HSA-5339562	2.766773e-01	0.558
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	2.771175e-01	0.557
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	2.803208e-01	0.552
PTK6 promotes HIF1A stabilization	R-HSA-8857538	2.851624e-01	0.545
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	2.851624e-01	0.545
Erythropoietin activates STAT5	R-HSA-9027283	2.851624e-01	0.545
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	2.851624e-01	0.545
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	2.851624e-01	0.545
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	2.851624e-01	0.545
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.851624e-01	0.545
Neurofascin interactions	R-HSA-447043	2.851624e-01	0.545
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.851624e-01	0.545
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	2.860646e-01	0.544
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.860646e-01	0.544
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.860646e-01	0.544
DNA strand elongation	R-HSA-69190	2.905518e-01	0.537
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.905716e-01	0.537
Disorders of Nervous System Development	R-HSA-9697154	2.905716e-01	0.537
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	2.905716e-01	0.537
Pervasive developmental disorders	R-HSA-9005895	2.905716e-01	0.537
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.905716e-01	0.537
Scavenging by Class F Receptors	R-HSA-3000484	2.905716e-01	0.537
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.905716e-01	0.537
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.905716e-01	0.537
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.905716e-01	0.537
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.905716e-01	0.537
Signaling by LTK	R-HSA-9842663	2.905716e-01	0.537
Signaling by juxtamembrane domain KIT mutants	R-HSA-9669935	2.969501e-01	0.527
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	2.969501e-01	0.527
Signaling by extracellular domain mutants of KIT	R-HSA-9680187	2.969501e-01	0.527
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	2.969501e-01	0.527
Interactions of Tat with host cellular proteins	R-HSA-176034	2.969501e-01	0.527
Defective HK1 causes hexokinase deficiency (HK deficiency)	R-HSA-5619056	2.969501e-01	0.527
Signaling by TCF7L2 mutants	R-HSA-5339700	2.969501e-01	0.527
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.969501e-01	0.527
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	2.969501e-01	0.527
Signaling by kinase domain mutants of KIT	R-HSA-9669933	2.969501e-01	0.527
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	2.969501e-01	0.527
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.969501e-01	0.527
PTEN Loss of Function in Cancer	R-HSA-5674404	2.969501e-01	0.527
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	2.969501e-01	0.527
TRAF3 deficiency - HSE	R-HSA-5602571	2.969501e-01	0.527
Defective VWF binding to collagen type I	R-HSA-9845622	2.969501e-01	0.527
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.969501e-01	0.527
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.969501e-01	0.527
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	2.969501e-01	0.527
Mitochondrial transcription initiation	R-HSA-163282	2.969501e-01	0.527
Transport of connexins along the secretory pathway	R-HSA-190827	2.969501e-01	0.527
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.969501e-01	0.527
Oligomerization of connexins into connexons	R-HSA-190704	2.969501e-01	0.527
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.984833e-01	0.525
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	2.984833e-01	0.525
Plasma lipoprotein clearance	R-HSA-8964043	2.984833e-01	0.525
Tight junction interactions	R-HSA-420029	3.012327e-01	0.521
VEGFR2 mediated cell proliferation	R-HSA-5218921	3.012327e-01	0.521
Parasite infection	R-HSA-9664407	3.042840e-01	0.517
Leishmania phagocytosis	R-HSA-9664417	3.042840e-01	0.517
FCGR3A-mediated phagocytosis	R-HSA-9664422	3.042840e-01	0.517
G-protein beta:gamma signalling	R-HSA-397795	3.106759e-01	0.508
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.106759e-01	0.508
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.121190e-01	0.506
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	3.121190e-01	0.506
O2/CO2 exchange in erythrocytes	R-HSA-1480926	3.121190e-01	0.506
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.121190e-01	0.506
HIV Transcription Elongation	R-HSA-167169	3.168854e-01	0.499
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	3.168854e-01	0.499
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	3.210824e-01	0.493
Formation of axial mesoderm	R-HSA-9796292	3.223313e-01	0.492
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	3.223313e-01	0.492
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	3.223313e-01	0.492
PI5P Regulates TP53 Acetylation	R-HSA-6811555	3.223313e-01	0.492
Interleukin-6 signaling	R-HSA-1059683	3.223313e-01	0.492
Maturation of nucleoprotein	R-HSA-9683610	3.223313e-01	0.492
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	3.223313e-01	0.492
Gastrulation	R-HSA-9758941	3.231572e-01	0.491
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	3.239192e-01	0.490
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	3.239192e-01	0.490
MECP2 regulates transcription factors	R-HSA-9022707	3.280899e-01	0.484
RUNX3 regulates WNT signaling	R-HSA-8951430	3.280899e-01	0.484
MET activates PI3K/AKT signaling	R-HSA-8851907	3.280899e-01	0.484
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.280899e-01	0.484
TRIF-mediated programmed cell death	R-HSA-2562578	3.280899e-01	0.484
SOS-mediated signalling	R-HSA-112412	3.280899e-01	0.484
Disinhibition of SNARE formation	R-HSA-114516	3.280899e-01	0.484
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.280899e-01	0.484
Nef Mediated CD4 Down-regulation	R-HSA-167590	3.280899e-01	0.484
Activated NTRK2 signals through CDK5	R-HSA-9032845	3.280899e-01	0.484
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	3.280899e-01	0.484
Synthesis of PIPs in the nucleus	R-HSA-8847453	3.280899e-01	0.484
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	3.280899e-01	0.484
Regulation of PD-L1(CD274) translation	R-HSA-9909620	3.383741e-01	0.471
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	3.383741e-01	0.471
VxPx cargo-targeting to cilium	R-HSA-5620916	3.383741e-01	0.471
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	3.467802e-01	0.460
Insulin processing	R-HSA-264876	3.467802e-01	0.460
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	3.541020e-01	0.451
CRMPs in Sema3A signaling	R-HSA-399956	3.541020e-01	0.451
Retrograde neurotrophin signalling	R-HSA-177504	3.541020e-01	0.451
Translation of Structural Proteins	R-HSA-9683701	3.542148e-01	0.451
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	3.553687e-01	0.449
Ca2+ pathway	R-HSA-4086398	3.559959e-01	0.449
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.562750e-01	0.448
Signalling to RAS	R-HSA-167044	3.646993e-01	0.438
Phase 0 - rapid depolarisation	R-HSA-5576892	3.697299e-01	0.432
phospho-PLA2 pathway	R-HSA-111995	3.702855e-01	0.431
MET receptor recycling	R-HSA-8875656	3.702855e-01	0.431
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.702855e-01	0.431
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	3.702855e-01	0.431
RSK activation	R-HSA-444257	3.702855e-01	0.431
Rab regulation of trafficking	R-HSA-9007101	3.728712e-01	0.428
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.748630e-01	0.426
Defective F8 cleavage by thrombin	R-HSA-9672391	3.748630e-01	0.426
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	3.748630e-01	0.426
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	3.748630e-01	0.426
Potassium transport channels	R-HSA-1296067	3.748630e-01	0.426
Defective AHCY causes HMAHCHD	R-HSA-5578997	3.748630e-01	0.426
Influenza Virus Induced Apoptosis	R-HSA-168277	3.748630e-01	0.426
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.748630e-01	0.426
Transcription from mitochondrial promoters	R-HSA-75944	3.748630e-01	0.426
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.748630e-01	0.426
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	3.748630e-01	0.426
Neuronal System	R-HSA-112316	3.830428e-01	0.417
Beta-catenin phosphorylation cascade	R-HSA-196299	3.856762e-01	0.414
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	3.856762e-01	0.414
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	3.856762e-01	0.414
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	3.856762e-01	0.414
Deadenylation-dependent mRNA decay	R-HSA-429914	3.889832e-01	0.410
Regulation of beta-cell development	R-HSA-186712	3.889832e-01	0.410
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	3.909730e-01	0.408
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	3.926863e-01	0.406
DARPP-32 events	R-HSA-180024	3.926863e-01	0.406
G1/S-Specific Transcription	R-HSA-69205	3.927456e-01	0.406
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.927456e-01	0.406
RNA Polymerase III Transcription	R-HSA-74158	3.927456e-01	0.406
FLT3 signaling in disease	R-HSA-9682385	3.927456e-01	0.406
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	3.986394e-01	0.399
Transcription of the HIV genome	R-HSA-167172	4.026606e-01	0.395
RAB geranylgeranylation	R-HSA-8873719	4.054024e-01	0.392
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	4.113843e-01	0.386
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	4.113843e-01	0.386
MASTL Facilitates Mitotic Progression	R-HSA-2465910	4.113843e-01	0.386
Regulation of CDH11 gene transcription	R-HSA-9762293	4.113843e-01	0.386
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.113843e-01	0.386
Respiratory syncytial virus genome replication	R-HSA-9834752	4.113843e-01	0.386
Butyrophilin (BTN) family interactions	R-HSA-8851680	4.113843e-01	0.386
DAP12 signaling	R-HSA-2424491	4.155722e-01	0.381
Phase 4 - resting membrane potential	R-HSA-5576886	4.168716e-01	0.380
Phosphorylation of the APC/C	R-HSA-176412	4.168716e-01	0.380
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	4.168716e-01	0.380
Killing mechanisms	R-HSA-9664420	4.168716e-01	0.380
Notch-HLH transcription pathway	R-HSA-350054	4.170832e-01	0.380
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	4.170832e-01	0.380
Regulation of IFNA/IFNB signaling	R-HSA-912694	4.170832e-01	0.380
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.170832e-01	0.380
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.170832e-01	0.380
Fanconi Anemia Pathway	R-HSA-6783310	4.296660e-01	0.367
Regulation of PTEN mRNA translation	R-HSA-8943723	4.429279e-01	0.354
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	4.429279e-01	0.354
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	4.429279e-01	0.354
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	4.429279e-01	0.354
Extra-nuclear estrogen signaling	R-HSA-9009391	4.437559e-01	0.353
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.441456e-01	0.352
Classical Kir channels	R-HSA-1296053	4.441456e-01	0.352
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.441456e-01	0.352
MET activates STAT3	R-HSA-8875791	4.441456e-01	0.352
Intracellular oxygen transport	R-HSA-8981607	4.441456e-01	0.352
CASP5-mediated substrate cleavage	R-HSA-9960525	4.441456e-01	0.352
Histamine receptors	R-HSA-390650	4.441456e-01	0.352
CASP4-mediated substrate cleavage	R-HSA-9960519	4.441456e-01	0.352
G beta:gamma signalling through CDC42	R-HSA-8964616	4.475308e-01	0.349
SHC1 events in ERBB4 signaling	R-HSA-1250347	4.475308e-01	0.349
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	4.475308e-01	0.349
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	4.475308e-01	0.349
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	4.475308e-01	0.349
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	4.484375e-01	0.348
Binding and entry of HIV virion	R-HSA-173107	4.511115e-01	0.346
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	4.511115e-01	0.346
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	4.511115e-01	0.346
EGFR Transactivation by Gastrin	R-HSA-2179392	4.511115e-01	0.346
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.511115e-01	0.346
Receptor Mediated Mitophagy	R-HSA-8934903	4.511115e-01	0.346
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.511115e-01	0.346
Tandem pore domain potassium channels	R-HSA-1296346	4.511115e-01	0.346
Signaling by Leptin	R-HSA-2586552	4.511115e-01	0.346
Pentose phosphate pathway	R-HSA-71336	4.542870e-01	0.343
RAS processing	R-HSA-9648002	4.542870e-01	0.343
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	4.542870e-01	0.343
Signaling by WNT in cancer	R-HSA-4791275	4.608488e-01	0.336
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	4.684154e-01	0.329
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	4.684154e-01	0.329
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	4.745132e-01	0.324
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	4.745132e-01	0.324
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	4.775193e-01	0.321
Elevation of cytosolic Ca2+ levels	R-HSA-139853	4.775193e-01	0.321
Regulation of NPAS4 gene expression	R-HSA-9768759	4.775193e-01	0.321
Uptake and function of anthrax toxins	R-HSA-5210891	4.775193e-01	0.321
Nuclear RNA decay	R-HSA-9930044	4.831108e-01	0.316
NGF-stimulated transcription	R-HSA-9031628	4.855916e-01	0.314
Inositol phosphate metabolism	R-HSA-1483249	4.890864e-01	0.311
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	4.892663e-01	0.310
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	4.892663e-01	0.310
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	4.892663e-01	0.310
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	4.892663e-01	0.310
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	4.892663e-01	0.310
Ionotropic activity of kainate receptors	R-HSA-451306	4.892663e-01	0.310
Bicarbonate transporters	R-HSA-425381	4.892663e-01	0.310
Signaling by APC mutants	R-HSA-4839744	4.892663e-01	0.310
vRNP Assembly	R-HSA-192905	4.892663e-01	0.310
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.892663e-01	0.310
HDMs demethylate histones	R-HSA-3214842	4.934637e-01	0.307
Interleukin-7 signaling	R-HSA-1266695	4.934637e-01	0.307
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	5.039028e-01	0.298
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.050451e-01	0.297
Effects of PIP2 hydrolysis	R-HSA-114508	5.050451e-01	0.297
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.057533e-01	0.296
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.057533e-01	0.296
GRB7 events in ERBB2 signaling	R-HSA-1306955	5.057533e-01	0.296
Extrinsic Pathway of Fibrin Clot Formation	R-HSA-140834	5.057533e-01	0.296
TNFR1-mediated ceramide production	R-HSA-5626978	5.057533e-01	0.296
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.057533e-01	0.296
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	5.057533e-01	0.296
Activation of NOXA and translocation to mitochondria	R-HSA-111448	5.057533e-01	0.296
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	5.057533e-01	0.296
Toxicity of tetanus toxin (tetX)	R-HSA-5250982	5.057533e-01	0.296
RNA Polymerase III Transcription Termination	R-HSA-73980	5.067248e-01	0.295
Polo-like kinase mediated events	R-HSA-156711	5.067248e-01	0.295
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	5.067248e-01	0.295
Signaling by FGFR1 in disease	R-HSA-5655302	5.142597e-01	0.289
MET activates PTK2 signaling	R-HSA-8874081	5.180010e-01	0.286
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.189622e-01	0.285
Azathioprine ADME	R-HSA-9748787	5.219930e-01	0.282
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.257094e-01	0.279
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	5.257094e-01	0.279
PI3K events in ERBB4 signaling	R-HSA-1250342	5.257094e-01	0.279
Signaling by AXIN mutants	R-HSA-4839735	5.257094e-01	0.279
eNOS activation	R-HSA-203615	5.266011e-01	0.279
Calnexin/calreticulin cycle	R-HSA-901042	5.266011e-01	0.279
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	5.337005e-01	0.273
Impaired BRCA2 binding to PALB2	R-HSA-9709603	5.350553e-01	0.272
Signaling by FGFR2 IIIa TM	R-HSA-8851708	5.350553e-01	0.272
The NLRP3 inflammasome	R-HSA-844456	5.350553e-01	0.272
Maturation of nucleoprotein	R-HSA-9694631	5.350553e-01	0.272
Protein localization	R-HSA-9609507	5.374159e-01	0.270
The phototransduction cascade	R-HSA-2514856	5.398323e-01	0.268
RNA Polymerase I Transcription Termination	R-HSA-73863	5.419650e-01	0.266
ER Quality Control Compartment (ERQC)	R-HSA-901032	5.419650e-01	0.266
Metabolism of polyamines	R-HSA-351202	5.452832e-01	0.263
Neddylation	R-HSA-8951664	5.483582e-01	0.261
TBC/RABGAPs	R-HSA-8854214	5.528057e-01	0.257
G alpha (12/13) signalling events	R-HSA-416482	5.547717e-01	0.256
Neurexins and neuroligins	R-HSA-6794361	5.573933e-01	0.254
Cardiac conduction	R-HSA-5576891	5.578687e-01	0.253
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.589985e-01	0.253
Repression of WNT target genes	R-HSA-4641265	5.603516e-01	0.252
Polymerase switching	R-HSA-69091	5.603516e-01	0.252
Leading Strand Synthesis	R-HSA-69109	5.603516e-01	0.252
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.603516e-01	0.252
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.603516e-01	0.252
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.603516e-01	0.252
OAS antiviral response	R-HSA-8983711	5.603516e-01	0.252
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.605360e-01	0.251
G2 Phase	R-HSA-68911	5.605360e-01	0.251
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.605360e-01	0.251
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.605360e-01	0.251
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.605360e-01	0.251
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.605360e-01	0.251
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.605360e-01	0.251
Activation of AKT2	R-HSA-165158	5.605360e-01	0.251
Suppression of autophagy	R-HSA-9636569	5.605360e-01	0.251
Muscarinic acetylcholine receptors	R-HSA-390648	5.605360e-01	0.251
Pyrophosphate hydrolysis	R-HSA-71737	5.605360e-01	0.251
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.605360e-01	0.251
Reelin signalling pathway	R-HSA-8866376	5.605360e-01	0.251
Ion channel transport	R-HSA-983712	5.620932e-01	0.250
Formation of ATP by chemiosmotic coupling	R-HSA-163210	5.624373e-01	0.250
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	5.624373e-01	0.250
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	5.624373e-01	0.250
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	5.624373e-01	0.250
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	5.624373e-01	0.250
Signaling by NODAL	R-HSA-1181150	5.624373e-01	0.250
Mitochondrial protein degradation	R-HSA-9837999	5.629618e-01	0.250
Telomere Extension By Telomerase	R-HSA-171319	5.653023e-01	0.248
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	5.653023e-01	0.248
Formation of the Early Elongation Complex	R-HSA-113418	5.653023e-01	0.248
NCAM signaling for neurite out-growth	R-HSA-375165	5.776919e-01	0.238
Signaling by Erythropoietin	R-HSA-9006335	5.879686e-01	0.231
mRNA Capping	R-HSA-72086	5.879686e-01	0.231
TNFR1-induced proapoptotic signaling	R-HSA-5357786	5.888143e-01	0.230
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	5.888143e-01	0.230
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	5.888143e-01	0.230
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.931442e-01	0.227
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	5.931442e-01	0.227
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	5.931442e-01	0.227
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.931442e-01	0.227
Reversible hydration of carbon dioxide	R-HSA-1475029	5.931442e-01	0.227
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.931442e-01	0.227
G alpha (z) signalling events	R-HSA-418597	6.081678e-01	0.216
Insulin receptor signalling cascade	R-HSA-74751	6.089906e-01	0.215
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.092494e-01	0.215
Plus-strand DNA synthesis	R-HSA-164525	6.092494e-01	0.215
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.092494e-01	0.215
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.092494e-01	0.215
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.092494e-01	0.215
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.092494e-01	0.215
Signaling by MAPK mutants	R-HSA-9652817	6.092494e-01	0.215
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.092494e-01	0.215
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	6.092494e-01	0.215
Pentose phosphate pathway disease	R-HSA-6791465	6.092494e-01	0.215
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.092494e-01	0.215
PKB-mediated events	R-HSA-109703	6.092494e-01	0.215
CDC6 association with the ORC:origin complex	R-HSA-68689	6.092494e-01	0.215
PDE3B signalling	R-HSA-165160	6.092494e-01	0.215
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	6.092494e-01	0.215
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.092494e-01	0.215
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.092494e-01	0.215
RNA Polymerase III Transcription Initiation	R-HSA-76046	6.099275e-01	0.215
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	6.099275e-01	0.215
Mitochondrial calcium ion transport	R-HSA-8949215	6.141447e-01	0.212
Ribavirin ADME	R-HSA-9755088	6.141447e-01	0.212
Disorders of transmembrane transporters	R-HSA-5619115	6.208816e-01	0.207
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	6.240718e-01	0.205
Signaling by FGFR4 in disease	R-HSA-5655291	6.240718e-01	0.205
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	6.240718e-01	0.205
NRAGE signals death through JNK	R-HSA-193648	6.243887e-01	0.205
Signaling by FGFR in disease	R-HSA-1226099	6.244479e-01	0.205
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.273060e-01	0.203
Neurotoxicity of clostridium toxins	R-HSA-168799	6.384008e-01	0.195
LDL clearance	R-HSA-8964038	6.384008e-01	0.195
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.458228e-01	0.190
Protein-protein interactions at synapses	R-HSA-6794362	6.514819e-01	0.186
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.525656e-01	0.185
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.525656e-01	0.185
Autointegration results in viral DNA circles	R-HSA-177539	6.525656e-01	0.185
G2/M DNA replication checkpoint	R-HSA-69478	6.525656e-01	0.185
Uncoating of the HIV Virion	R-HSA-162585	6.525656e-01	0.185
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.525656e-01	0.185
MET Receptor Activation	R-HSA-6806942	6.525656e-01	0.185
Integration of viral DNA into host genomic DNA	R-HSA-175567	6.525656e-01	0.185
Regulation of NFE2L2 gene expression	R-HSA-9818749	6.525656e-01	0.185
Defective factor VIII causes hemophilia A	R-HSA-9662001	6.525656e-01	0.185
CREB phosphorylation	R-HSA-199920	6.525656e-01	0.185
VLDL assembly	R-HSA-8866423	6.525656e-01	0.185
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	6.531448e-01	0.185
Erythropoietin activates RAS	R-HSA-9027284	6.531448e-01	0.185
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	6.531448e-01	0.185
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	6.531448e-01	0.185
Signaling by Activin	R-HSA-1502540	6.531448e-01	0.185
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.679956e-01	0.175
Extension of Telomeres	R-HSA-180786	6.707193e-01	0.173
Peroxisomal protein import	R-HSA-9033241	6.707193e-01	0.173
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.713076e-01	0.173
FGFR1 mutant receptor activation	R-HSA-1839124	6.713076e-01	0.173
PI3K Cascade	R-HSA-109704	6.749487e-01	0.171
Leishmania infection	R-HSA-9658195	6.780442e-01	0.169
Parasitic Infection Pathways	R-HSA-9824443	6.780442e-01	0.169
Integrin cell surface interactions	R-HSA-216083	6.788493e-01	0.168
Class I peroxisomal membrane protein import	R-HSA-9603798	6.803943e-01	0.167
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.803943e-01	0.167
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	6.803943e-01	0.167
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.803943e-01	0.167
Differentiation of T cells	R-HSA-9945266	6.803943e-01	0.167
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.803943e-01	0.167
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.803943e-01	0.167
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	6.810761e-01	0.167
HIV Transcription Initiation	R-HSA-167161	6.810761e-01	0.167
RNA Polymerase II Transcription Initiation	R-HSA-75953	6.810761e-01	0.167
Interferon gamma signaling	R-HSA-877300	6.832268e-01	0.165
TRAF6 mediated NF-kB activation	R-HSA-933542	6.836361e-01	0.165
Mitochondrial RNA degradation	R-HSA-9836573	6.836361e-01	0.165
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	6.836361e-01	0.165
Interleukin-6 family signaling	R-HSA-6783589	6.836361e-01	0.165
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.902177e-01	0.161
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.910822e-01	0.160
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.910822e-01	0.160
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	6.910822e-01	0.160
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.910822e-01	0.160
PTK6 Expression	R-HSA-8849473	6.910822e-01	0.160
Opsins	R-HSA-419771	6.910822e-01	0.160
Mitochondrial ABC transporters	R-HSA-1369007	6.910822e-01	0.160
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.910822e-01	0.160
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.910822e-01	0.160
VLDL clearance	R-HSA-8964046	6.910822e-01	0.160
LDL remodeling	R-HSA-8964041	6.910822e-01	0.160
Netrin mediated repulsion signals	R-HSA-418886	6.910822e-01	0.160
IRS-related events triggered by IGF1R	R-HSA-2428928	6.995539e-01	0.155
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	7.046131e-01	0.152
Formation of the nephric duct	R-HSA-9830364	7.046131e-01	0.152
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.046131e-01	0.152
Acetylcholine regulates insulin secretion	R-HSA-399997	7.058672e-01	0.151
Coenzyme A biosynthesis	R-HSA-196783	7.058672e-01	0.151
Passive transport by Aquaporins	R-HSA-432047	7.058672e-01	0.151
Synthesis of PG	R-HSA-1483148	7.058672e-01	0.151
Response to metal ions	R-HSA-5660526	7.058672e-01	0.151
RSV-host interactions	R-HSA-9833110	7.076604e-01	0.150
Signal amplification	R-HSA-392518	7.083417e-01	0.150
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.083417e-01	0.150
tRNA processing	R-HSA-72306	7.094377e-01	0.149
FCERI mediated NF-kB activation	R-HSA-2871837	7.109865e-01	0.148
Mitochondrial protein import	R-HSA-1268020	7.133331e-01	0.147
Heme signaling	R-HSA-9707616	7.133331e-01	0.147
RNA Polymerase II Promoter Escape	R-HSA-73776	7.138933e-01	0.146
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	7.208814e-01	0.142
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.245085e-01	0.140
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.245085e-01	0.140
Reverse Transcription of HIV RNA	R-HSA-162589	7.253309e-01	0.139
Minus-strand DNA synthesis	R-HSA-164516	7.253309e-01	0.139
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.253309e-01	0.139
Activated NTRK2 signals through PI3K	R-HSA-9028335	7.253309e-01	0.139
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.253309e-01	0.139
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.253309e-01	0.139
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	7.253309e-01	0.139
Regulation by c-FLIP	R-HSA-3371378	7.253309e-01	0.139
FGFR1b ligand binding and activation	R-HSA-190370	7.253309e-01	0.139
Co-stimulation by ICOS	R-HSA-9927354	7.253309e-01	0.139
Interleukin-9 signaling	R-HSA-8985947	7.253309e-01	0.139
TGFBR3 PTM regulation	R-HSA-9839383	7.253309e-01	0.139
SLC-mediated bile acid transport	R-HSA-9958517	7.253309e-01	0.139
Dimerization of procaspase-8	R-HSA-69416	7.253309e-01	0.139
Interleukin-23 signaling	R-HSA-9020933	7.253309e-01	0.139
Platelet homeostasis	R-HSA-418346	7.286192e-01	0.137
DAP12 interactions	R-HSA-2172127	7.293779e-01	0.137
Amine ligand-binding receptors	R-HSA-375280	7.293779e-01	0.137
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	7.296225e-01	0.137
Specification of primordial germ cells	R-HSA-9827857	7.296225e-01	0.137
Replication of the SARS-CoV-2 genome	R-HSA-9694686	7.296225e-01	0.137
IGF1R signaling cascade	R-HSA-2428924	7.395959e-01	0.131
Triglyceride catabolism	R-HSA-163560	7.422386e-01	0.129
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	7.433401e-01	0.129
Maturation of hRSV A proteins	R-HSA-9828806	7.433401e-01	0.129
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.442468e-01	0.128
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.442468e-01	0.128
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	7.517279e-01	0.124
PKA activation	R-HSA-163615	7.517279e-01	0.124
PKA activation in glucagon signalling	R-HSA-164378	7.517279e-01	0.124
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	7.517279e-01	0.124
Synaptic adhesion-like molecules	R-HSA-8849932	7.517279e-01	0.124
Nephron development	R-HSA-9831926	7.517279e-01	0.124
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	7.517279e-01	0.124
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	7.520767e-01	0.124
MAPK1 (ERK2) activation	R-HSA-112411	7.557844e-01	0.122
CASP8 activity is inhibited	R-HSA-5218900	7.557844e-01	0.122
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.557844e-01	0.122
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.557844e-01	0.122
Interleukin-21 signaling	R-HSA-9020958	7.557844e-01	0.122
Regulation of signaling by NODAL	R-HSA-1433617	7.557844e-01	0.122
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.557844e-01	0.122
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.557844e-01	0.122
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.557844e-01	0.122
Regulated proteolysis of p75NTR	R-HSA-193692	7.557844e-01	0.122
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	7.557844e-01	0.122
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.557844e-01	0.122
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	7.557844e-01	0.122
Signaling by Insulin receptor	R-HSA-74752	7.565132e-01	0.121
TRAF6 mediated IRF7 activation	R-HSA-933541	7.580254e-01	0.120
Activation of kainate receptors upon glutamate binding	R-HSA-451326	7.611307e-01	0.119
Pyroptosis	R-HSA-5620971	7.611307e-01	0.119
Inflammasomes	R-HSA-622312	7.611307e-01	0.119
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.721548e-01	0.112
PI-3K cascade:FGFR3	R-HSA-5654710	7.722571e-01	0.112
Germ layer formation at gastrulation	R-HSA-9754189	7.722571e-01	0.112
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.722571e-01	0.112
Other interleukin signaling	R-HSA-449836	7.722571e-01	0.112
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.722571e-01	0.112
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.730526e-01	0.112
IRS-mediated signalling	R-HSA-112399	7.733508e-01	0.112
Metabolism of amino acids and derivatives	R-HSA-71291	7.772699e-01	0.109
Impaired BRCA2 binding to RAD51	R-HSA-9709570	7.779078e-01	0.109
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	7.779195e-01	0.109
Translation of Structural Proteins	R-HSA-9694635	7.788391e-01	0.109
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.828629e-01	0.106
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.828629e-01	0.106
Interleukin-27 signaling	R-HSA-9020956	7.828629e-01	0.106
GPER1 signaling	R-HSA-9634597	7.852080e-01	0.105
PI-3K cascade:FGFR4	R-HSA-5654720	7.912879e-01	0.102
Creatine metabolism	R-HSA-71288	7.912879e-01	0.102
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	7.937025e-01	0.100
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.937025e-01	0.100
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	7.937025e-01	0.100
Interleukin-2 family signaling	R-HSA-451927	8.008898e-01	0.096
Conjugation of benzoate with glycine	R-HSA-177135	8.069404e-01	0.093
vRNA Synthesis	R-HSA-192814	8.069404e-01	0.093
Chylomicron assembly	R-HSA-8963888	8.069404e-01	0.093
RHOBTB3 ATPase cycle	R-HSA-9706019	8.069404e-01	0.093
Vitamin B1 (thiamin) metabolism	R-HSA-196819	8.069404e-01	0.093
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.069404e-01	0.093
Interleukin-2 signaling	R-HSA-9020558	8.069404e-01	0.093
Dissolution of Fibrin Clot	R-HSA-75205	8.069404e-01	0.093
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.085487e-01	0.092
Downstream signal transduction	R-HSA-186763	8.085487e-01	0.092
Molecules associated with elastic fibres	R-HSA-2129379	8.085487e-01	0.092
MyD88 deficiency (TLR2/4)	R-HSA-5602498	8.089000e-01	0.092
Lagging Strand Synthesis	R-HSA-69186	8.089000e-01	0.092
G-protein activation	R-HSA-202040	8.089000e-01	0.092
PKA-mediated phosphorylation of CREB	R-HSA-111931	8.089000e-01	0.092
Zygotic genome activation (ZGA)	R-HSA-9819196	8.089000e-01	0.092
Signaling by FGFR2 in disease	R-HSA-5655253	8.095617e-01	0.092
Resolution of Abasic Sites (AP sites)	R-HSA-73933	8.137361e-01	0.090
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.137361e-01	0.090
Inwardly rectifying K+ channels	R-HSA-1296065	8.224821e-01	0.085
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.224821e-01	0.085
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	8.251740e-01	0.083
Serine metabolism	R-HSA-977347	8.251740e-01	0.083
Signaling by NTRK3 (TRKC)	R-HSA-9034015	8.251740e-01	0.083
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	8.251740e-01	0.083
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.258946e-01	0.083
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.283493e-01	0.082
Proton-coupled monocarboxylate transport	R-HSA-433692	8.283493e-01	0.082
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	8.283493e-01	0.082
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	8.283493e-01	0.082
Plasmalogen biosynthesis	R-HSA-75896	8.283493e-01	0.082
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	8.283493e-01	0.082
Sensing of DNA Double Strand Breaks	R-HSA-5693548	8.283493e-01	0.082
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.287037e-01	0.082
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	8.355403e-01	0.078
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.355403e-01	0.078
Cytoprotection by HMOX1	R-HSA-9707564	8.361223e-01	0.078
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.383663e-01	0.077
PI-3K cascade:FGFR1	R-HSA-5654689	8.401901e-01	0.076
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	8.401901e-01	0.076
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	8.401901e-01	0.076
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	8.401901e-01	0.076
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	8.401901e-01	0.076
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.443600e-01	0.073
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.443600e-01	0.073
MET activates RAS signaling	R-HSA-8851805	8.473853e-01	0.072
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.473853e-01	0.072
GRB2 events in EGFR signaling	R-HSA-179812	8.473853e-01	0.072
Acetylation	R-HSA-156582	8.473853e-01	0.072
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.473853e-01	0.072
Conjugation of salicylate with glycine	R-HSA-177128	8.473853e-01	0.072
Interleukin-35 Signalling	R-HSA-8984722	8.473853e-01	0.072
Trafficking and processing of endosomal TLR	R-HSA-1679131	8.473853e-01	0.072
Synthesis of GDP-mannose	R-HSA-446205	8.473853e-01	0.072
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.473853e-01	0.072
Resolution of D-Loop Structures	R-HSA-5693537	8.477616e-01	0.072
Glucagon signaling in metabolic regulation	R-HSA-163359	8.477616e-01	0.072
Glutamate and glutamine metabolism	R-HSA-8964539	8.477616e-01	0.072
Interleukin receptor SHC signaling	R-HSA-912526	8.540271e-01	0.069
Formation of the ureteric bud	R-HSA-9830674	8.540271e-01	0.069
Mitochondrial mRNA modification	R-HSA-9937008	8.540271e-01	0.069
Interleukin-20 family signaling	R-HSA-8854691	8.540271e-01	0.069
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.591849e-01	0.066
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.591849e-01	0.066
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.591849e-01	0.066
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.643111e-01	0.063
Processing of SMDT1	R-HSA-8949664	8.643111e-01	0.063
FGFR1c ligand binding and activation	R-HSA-190373	8.643111e-01	0.063
rRNA modification in the mitochondrion	R-HSA-6793080	8.643111e-01	0.063
Infection with Mycobacterium tuberculosis	R-HSA-9635486	8.666198e-01	0.062
Plasma lipoprotein assembly	R-HSA-8963898	8.667616e-01	0.062
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	8.673484e-01	0.062
Transferrin endocytosis and recycling	R-HSA-917977	8.698492e-01	0.061
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	8.698492e-01	0.061
Kidney development	R-HSA-9830369	8.726874e-01	0.059
SLC transporter disorders	R-HSA-5619102	8.729195e-01	0.059
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.771731e-01	0.057
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.771731e-01	0.057
Dectin-2 family	R-HSA-5621480	8.778454e-01	0.057
PI-3K cascade:FGFR2	R-HSA-5654695	8.784681e-01	0.056
G protein gated Potassium channels	R-HSA-1296059	8.784681e-01	0.056
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.784681e-01	0.056
Activation of G protein gated Potassium channels	R-HSA-1296041	8.784681e-01	0.056
Polymerase switching on the C-strand of the telomere	R-HSA-174411	8.784681e-01	0.056
Laminin interactions	R-HSA-3000157	8.784681e-01	0.056
Removal of the Flap Intermediate	R-HSA-69166	8.793607e-01	0.056
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.793607e-01	0.056
Hydrolysis of LPC	R-HSA-1483115	8.793607e-01	0.056
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.793607e-01	0.056
Non-canonical inflammasome activation	R-HSA-9686114	8.793607e-01	0.056
HDL assembly	R-HSA-8963896	8.793607e-01	0.056
Acyl chain remodeling of CL	R-HSA-1482798	8.793607e-01	0.056
Zinc transporters	R-HSA-435354	8.793607e-01	0.056
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.797933e-01	0.056
FGFR2 mutant receptor activation	R-HSA-1839126	8.797933e-01	0.056
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.805924e-01	0.055
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.835909e-01	0.054
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.836928e-01	0.054
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.856610e-01	0.053
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.892178e-01	0.051
TRP channels	R-HSA-3295583	8.892178e-01	0.051
Regulation of insulin secretion	R-HSA-422356	8.915430e-01	0.050
SHC1 events in EGFR signaling	R-HSA-180336	8.927418e-01	0.049
RNA Polymerase III Chain Elongation	R-HSA-73780	8.927418e-01	0.049
G beta:gamma signalling through BTK	R-HSA-8964315	8.927418e-01	0.049
Processive synthesis on the lagging strand	R-HSA-69183	8.927418e-01	0.049
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	8.927418e-01	0.049
Lysosphingolipid and LPA receptors	R-HSA-419408	8.927418e-01	0.049
Other semaphorin interactions	R-HSA-416700	8.927418e-01	0.049
DNA Damage Reversal	R-HSA-73942	8.927418e-01	0.049
COPII-mediated vesicle transport	R-HSA-204005	8.942368e-01	0.049
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	8.976734e-01	0.047
Elastic fibre formation	R-HSA-1566948	8.976734e-01	0.047
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.990789e-01	0.046
Signaling by FGFR3 in disease	R-HSA-5655332	8.990789e-01	0.046
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.000111e-01	0.046
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.016935e-01	0.045
Defective GALNT3 causes HFTC	R-HSA-5083625	9.046395e-01	0.044
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	9.046395e-01	0.044
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.046395e-01	0.044
Activation of the phototransduction cascade	R-HSA-2485179	9.046395e-01	0.044
Fructose catabolism	R-HSA-70350	9.046395e-01	0.044
Induction of Cell-Cell Fusion	R-HSA-9733458	9.046395e-01	0.044
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	9.046395e-01	0.044
Activation of SMO	R-HSA-5635838	9.046395e-01	0.044
Attachment and Entry	R-HSA-9678110	9.046395e-01	0.044
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.056836e-01	0.043
Aquaporin-mediated transport	R-HSA-445717	9.065807e-01	0.043
Insulin receptor recycling	R-HSA-77387	9.081163e-01	0.042
Diseases of carbohydrate metabolism	R-HSA-5663084	9.125919e-01	0.040
Signaling by PDGF	R-HSA-186797	9.127699e-01	0.040
Diseases of Immune System	R-HSA-5260271	9.131218e-01	0.039
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.131218e-01	0.039
Fibronectin matrix formation	R-HSA-1566977	9.152180e-01	0.038
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.152180e-01	0.038
Heme assimilation	R-HSA-9927020	9.152180e-01	0.038
Transcriptional regulation of testis differentiation	R-HSA-9690406	9.152180e-01	0.038
Galactose catabolism	R-HSA-70370	9.152180e-01	0.038
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.152180e-01	0.038
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.152180e-01	0.038
tRNA modification in the mitochondrion	R-HSA-6787450	9.152180e-01	0.038
Downstream signaling of activated FGFR3	R-HSA-5654708	9.163912e-01	0.038
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.163912e-01	0.038
Extracellular matrix organization	R-HSA-1474244	9.190771e-01	0.037
Downstream signaling of activated FGFR4	R-HSA-5654716	9.239617e-01	0.034
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.239617e-01	0.034
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	9.246235e-01	0.034
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.246235e-01	0.034
Sulfide oxidation to sulfate	R-HSA-1614517	9.246235e-01	0.034
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	9.246235e-01	0.034
Choline catabolism	R-HSA-6798163	9.246235e-01	0.034
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.246235e-01	0.034
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	9.246235e-01	0.034
Cell surface interactions at the vascular wall	R-HSA-202733	9.256484e-01	0.034
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.264185e-01	0.033
Intra-Golgi traffic	R-HSA-6811438	9.264185e-01	0.033
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.264185e-01	0.033
Amino acids regulate mTORC1	R-HSA-9639288	9.267354e-01	0.033
Nucleotide biosynthesis	R-HSA-8956320	9.267354e-01	0.033
Cytosolic tRNA aminoacylation	R-HSA-379716	9.323418e-01	0.030
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.323418e-01	0.030
G beta:gamma signalling through PLC beta	R-HSA-418217	9.329862e-01	0.030
Presynaptic function of Kainate receptors	R-HSA-500657	9.329862e-01	0.030
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.329862e-01	0.030
FGFR1 ligand binding and activation	R-HSA-190242	9.329862e-01	0.030
FOXO-mediated transcription of cell death genes	R-HSA-9614657	9.329862e-01	0.030
Tie2 Signaling	R-HSA-210993	9.329862e-01	0.030
Mismatch Repair	R-HSA-5358508	9.329862e-01	0.030
Paracetamol ADME	R-HSA-9753281	9.371277e-01	0.028
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	9.404214e-01	0.027
Specification of the neural plate border	R-HSA-9834899	9.404214e-01	0.027
Conjugation of carboxylic acids	R-HSA-159424	9.404214e-01	0.027
Amino Acid conjugation	R-HSA-156587	9.404214e-01	0.027
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.404214e-01	0.027
Diseases of hemostasis	R-HSA-9671793	9.404214e-01	0.027
Methionine salvage pathway	R-HSA-1237112	9.404214e-01	0.027
Stimuli-sensing channels	R-HSA-2672351	9.413482e-01	0.026
Cardiogenesis	R-HSA-9733709	9.429733e-01	0.026
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.429733e-01	0.026
Integration of energy metabolism	R-HSA-163685	9.451210e-01	0.025
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.470321e-01	0.024
Acyl chain remodelling of PI	R-HSA-1482922	9.470321e-01	0.024
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.470321e-01	0.024
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.475728e-01	0.023
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.482364e-01	0.023
Miscellaneous transport and binding events	R-HSA-5223345	9.482364e-01	0.023
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.502192e-01	0.022
Diseases of DNA repair	R-HSA-9675135	9.518954e-01	0.021
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.529097e-01	0.021
Phenylalanine metabolism	R-HSA-8964208	9.529097e-01	0.021
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.529097e-01	0.021
Acyl chain remodelling of PG	R-HSA-1482925	9.529097e-01	0.021
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.529097e-01	0.021
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.530341e-01	0.021
Hyaluronan metabolism	R-HSA-2142845	9.530341e-01	0.021
FCERI mediated MAPK activation	R-HSA-2871796	9.537043e-01	0.021
Amino acid transport across the plasma membrane	R-HSA-352230	9.539935e-01	0.020
Triglyceride metabolism	R-HSA-8979227	9.539935e-01	0.020
ECM proteoglycans	R-HSA-3000178	9.540690e-01	0.020
Synthesis of PC	R-HSA-1483191	9.558833e-01	0.020
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.570258e-01	0.019
Adipogenesis	R-HSA-9843745	9.572779e-01	0.019
Downstream signaling of activated FGFR2	R-HSA-5654696	9.574048e-01	0.019
Downstream signaling of activated FGFR1	R-HSA-5654687	9.574048e-01	0.019
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.581353e-01	0.019
Androgen biosynthesis	R-HSA-193048	9.581353e-01	0.019
Attachment and Entry	R-HSA-9694614	9.581353e-01	0.019
Formation of the cornified envelope	R-HSA-6809371	9.614904e-01	0.017
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.627813e-01	0.016
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.627813e-01	0.016
Fructose metabolism	R-HSA-5652084	9.627813e-01	0.016
Ethanol oxidation	R-HSA-71384	9.627813e-01	0.016
Chemokine receptors bind chemokines	R-HSA-380108	9.629473e-01	0.016
Asparagine N-linked glycosylation	R-HSA-446203	9.651543e-01	0.015
Termination of O-glycan biosynthesis	R-HSA-977068	9.669120e-01	0.015
Biosynthesis of maresins	R-HSA-9018682	9.669120e-01	0.015
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.669120e-01	0.015
ABC transporters in lipid homeostasis	R-HSA-1369062	9.669120e-01	0.015
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.677814e-01	0.014
CYP2E1 reactions	R-HSA-211999	9.705844e-01	0.013
Thromboxane signalling through TP receptor	R-HSA-428930	9.705844e-01	0.013
Complex III assembly	R-HSA-9865881	9.705844e-01	0.013
TNFs bind their physiological receptors	R-HSA-5669034	9.705844e-01	0.013
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.738495e-01	0.012
Acyl chain remodelling of PS	R-HSA-1482801	9.738495e-01	0.012
Hyaluronan degradation	R-HSA-2160916	9.738495e-01	0.012
SLC-mediated transport of amino acids	R-HSA-9958863	9.759223e-01	0.011
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.767523e-01	0.010
Signaling by FLT3 fusion proteins	R-HSA-9703465	9.767523e-01	0.010
Urea cycle	R-HSA-70635	9.767523e-01	0.010
Sphingolipid catabolism	R-HSA-9845614	9.767523e-01	0.010
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.767523e-01	0.010
PI Metabolism	R-HSA-1483255	9.782494e-01	0.010
Scavenging by Class A Receptors	R-HSA-3000480	9.787238e-01	0.009
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.793330e-01	0.009
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.793330e-01	0.009
Activation of GABAB receptors	R-HSA-991365	9.807580e-01	0.008
GABA B receptor activation	R-HSA-977444	9.807580e-01	0.008
FCGR activation	R-HSA-2029481	9.811145e-01	0.008
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.816274e-01	0.008
Pyrimidine salvage	R-HSA-73614	9.816274e-01	0.008
Prednisone ADME	R-HSA-9757110	9.816274e-01	0.008
Synthesis of PA	R-HSA-1483166	9.818751e-01	0.008
Thyroxine biosynthesis	R-HSA-209968	9.836672e-01	0.007
Glucagon-type ligand receptors	R-HSA-420092	9.836672e-01	0.007
Role of phospholipids in phagocytosis	R-HSA-2029485	9.837914e-01	0.007
Methylation	R-HSA-156581	9.842756e-01	0.007
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.849000e-01	0.007
Neurotransmitter clearance	R-HSA-112311	9.854806e-01	0.006
Degradation of cysteine and homocysteine	R-HSA-1614558	9.857913e-01	0.006
Peptide hormone metabolism	R-HSA-2980736	9.858787e-01	0.006
Potassium Channels	R-HSA-1296071	9.860112e-01	0.006
tRNA Aminoacylation	R-HSA-379724	9.862247e-01	0.006
Signaling by Retinoic Acid	R-HSA-5362517	9.862247e-01	0.006
Cargo concentration in the ER	R-HSA-5694530	9.870928e-01	0.006
Aspartate and asparagine metabolism	R-HSA-8963693	9.870928e-01	0.006
Leishmania parasite growth and survival	R-HSA-9664433	9.888679e-01	0.005
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.888679e-01	0.005
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.896653e-01	0.005
Recycling of bile acids and salts	R-HSA-159418	9.898002e-01	0.004
Degradation of the extracellular matrix	R-HSA-1474228	9.901183e-01	0.004
Neurotransmitter release cycle	R-HSA-112310	9.903033e-01	0.004
SLC-mediated transport of organic anions	R-HSA-9955298	9.905218e-01	0.004
Acyl chain remodelling of PC	R-HSA-1482788	9.909329e-01	0.004
Heme degradation	R-HSA-189483	9.909329e-01	0.004
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.919399e-01	0.004
RA biosynthesis pathway	R-HSA-5365859	9.919399e-01	0.004
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.921134e-01	0.003
Acyl chain remodelling of PE	R-HSA-1482839	9.928351e-01	0.003
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.928351e-01	0.003
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.928351e-01	0.003
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.932176e-01	0.003
NCAM1 interactions	R-HSA-419037	9.943385e-01	0.002
Voltage gated Potassium channels	R-HSA-1296072	9.943385e-01	0.002
Phenylalanine and tyrosine metabolism	R-HSA-8963691	9.943385e-01	0.002
SLC-mediated transport of organic cations	R-HSA-549127	9.943385e-01	0.002
Collagen chain trimerization	R-HSA-8948216	9.943385e-01	0.002
Metabolism of folate and pterines	R-HSA-196757	9.943385e-01	0.002
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.949674e-01	0.002
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.949988e-01	0.002
Sulfur amino acid metabolism	R-HSA-1614635	9.957096e-01	0.002
Aspirin ADME	R-HSA-9749641	9.959395e-01	0.002
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.960235e-01	0.002
rRNA processing in the mitochondrion	R-HSA-8868766	9.960235e-01	0.002
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.960235e-01	0.002
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.963108e-01	0.002
ROS and RNS production in phagocytes	R-HSA-1222556	9.963108e-01	0.002
Maturation of spike protein	R-HSA-9694548	9.964653e-01	0.002
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.966489e-01	0.001
GABA receptor activation	R-HSA-977443	9.969812e-01	0.001
Class B/2 (Secretin family receptors)	R-HSA-373080	9.970057e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.971624e-01	0.001
G alpha (q) signalling events	R-HSA-416476	9.974456e-01	0.001
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.975176e-01	0.001
Pyrimidine catabolism	R-HSA-73621	9.975176e-01	0.001
Surfactant metabolism	R-HSA-5683826	9.977934e-01	0.001
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.977934e-01	0.001
CD22 mediated BCR regulation	R-HSA-5690714	9.980176e-01	0.001
The canonical retinoid cycle in rods (twilight vision)	R-HSA-2453902	9.980387e-01	0.001
Collagen formation	R-HSA-1474290	9.981009e-01	0.001
Nicotinate metabolism	R-HSA-196807	9.985564e-01	0.001
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.985590e-01	0.001
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.985888e-01	0.001
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.985961e-01	0.001
Metal ion SLC transporters	R-HSA-425410	9.986227e-01	0.001
Plasma lipoprotein remodeling	R-HSA-8963899	9.986227e-01	0.001
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.987016e-01	0.001
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.987758e-01	0.001
Visual phototransduction	R-HSA-2187338	9.988682e-01	0.000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.989119e-01	0.000
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.989502e-01	0.000
Complex IV assembly	R-HSA-9864848	9.990329e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.990562e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.993843e-01	0.000
PPARA activates gene expression	R-HSA-1989781	9.994007e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.994519e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.994636e-01	0.000
Interleukin-10 signaling	R-HSA-6783783	9.995537e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.996068e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.996379e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.996477e-01	0.000
Transport of small molecules	R-HSA-382551	9.996709e-01	0.000
Nucleotide salvage	R-HSA-8956321	9.997025e-01	0.000
Collagen degradation	R-HSA-1442490	9.997025e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.997650e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.997686e-01	0.000
Drug ADME	R-HSA-9748784	9.997814e-01	0.000
Xenobiotics	R-HSA-211981	9.997912e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998534e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.998534e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.998666e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.998697e-01	0.000
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.999086e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.999086e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.999086e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.999086e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999166e-01	0.000
Keratinization	R-HSA-6805567	9.999273e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.999600e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.999644e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999644e-01	0.000
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999719e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999719e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999763e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999766e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999922e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999962e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.999967e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999968e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999974e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999985e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.999986e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999987e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999992e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999994e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999994e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999995e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999995e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999995e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999996e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999998e-01	0.000
Complement cascade	R-HSA-166658	9.999999e-01	0.000
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Mitochondrial translation	R-HSA-5368287	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000