CSK

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A5A3E0 Y1062 Sugiyama POTEF A26C1B GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCL_______
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00116 Y645 Sugiyama AGPS AAG5 QWLKESIsDVGFGMLKSVKEyVDPNNIFGNRNLL_______
O00299 Y233 Sugiyama CLIC1 G6 NCC27 AyAREEFAstCPDDEEIELAyEQVAKALK____________
O00469 Y444 Sugiyama PLOD2 LWSNFWGALSPDGYYARsEDyVDIVQGNRVGVWNVPYMANV
O14818 Y176 Sugiyama PSMA7 HSPC WKANAIGRGAKSVREFLEKNyTDEAIETDDLTIKLVIKALL
O14950 Y156 Sugiyama MYL12B MRLC2 MYLC2B DEEVDELyREAPIDKKGNFNyIEFtRILKHGAKDKDD____
O15371 Y50 Sugiyama EIF3D EIF3S7 yQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGGSQYA
O15492 Y168 iPTMNet RGS16 RGSR TATCFDAAQGKTRTLMEKDSyPRFLKSPAyRDLAAQASAAS
O43390 Y136 Sugiyama HNRNPR HNRPR QESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O43707 Y212 Sugiyama ACTN4 WKDGLAFNALIHRHRPELIEyDKLRKDDPVTNLNNAFEVAE
O43707 Y441 Sugiyama ACTN4 KAsIHEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEs
O43852 Y106 Sugiyama CALU GFVtVDELKDWIKFAQKRWIyEDVERQWKGHDLNEDGLVsW
O43852 Y263 Sugiyama CALU KNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNKDG
O43852 Y47 Sugiyama CALU RVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQLtPE
O60331 Y649 GPS6|EPSD PIP5K1C KIAA0589 DEEDAPATDIyFPTDERSWVysPLHYSAQAPPAsDGEsDT_
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60506 Y133 Sugiyama SYNCRIP HNRPQ NSAP1 ADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60664 Y95 Sugiyama PLIN3 M6PRBP1 TIP47 VsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQPTE
O60739 Y30 Sugiyama EIF1B FDPFADATKGDDLLPAGTEDyIHIRIQQRNGRKtLttVQGI
O75116 Y936 Sugiyama ROCK2 KIAA0619 EITLTKADSEQLARsIAEEQysDLEKEKIMKELEIKEMMAR
O75223 Y156 Sugiyama GGCT C7orf24 CRF21 sPQYKKIICMGAKENGLPLEyQEKLKAIEPNDytGKVsEEI
O75347 Y75 Sugiyama TBCA EILQEsRMMIPDCQRRLEAAyLDLQRILENEKDLEEAEEyK
O75347 Y94 Sugiyama TBCA AyLDLQRILENEKDLEEAEEyKEARLVLDsVKLEA______
O95218 Y167 Sugiyama ZRANB2 ZIS ZNF265 EVEDKEsEGEEEDEDEDLsKyKLDEDEDEDDADLsKyNLDA
O95297 Y263 Sugiyama MPZL1 PZR UNQ849/PRO1787 QLDHsGGHHSDKINKSEsVVyADIRKN______________
O95757 Y30 Sugiyama HSPA4L APG1 HSPH3 OSP94 FLNCYIAVARsGGIETIANEySDRCtPACIsLGSRTRAIGN
P00338 Y10 Sugiyama LDHA PIG19 ___________MAtLKDQLIyNLLKEEQtPQNKITVVGVGA
P00338 Y239 Sugiyama LDHA PIG19 GtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVADL
P00390 Y371 Sugiyama GSR GLUR GRD1 TDDKGHIIVDEFQNtNVKGIyAVGDVCGKALLtPVAIAAGR
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P00558 Y196 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 MVGVNLPQKAGGFLMKKELNyFAKALEsPERPFLAILGGAK
P00966 Y163 Sugiyama ASS1 ASS APWRMPEFYNRFKGRNDLMEyAKQHGIPIPVtPKNPWSMDE
P02786 Y152 Sugiyama TFRC sEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVENQ
P04080 Y97 Sugiyama CSTB CST6 STFB NKPLtLsNyQTNKAKHDELtyF___________________
P04406 Y314 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 tFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsK
P04632 Y87 Sugiyama CAPNS1 CAPN4 CAPNS sAISEAAAQYNPEPPPPRtHysNIEANEsEEVRQFRRLFAQ
P05362 Y455 Sugiyama ICAM1 GtFPLPIGEsVtVtRDLEGtyLCRARSTQGEVTRKVTVNVL
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05787 Y204 Sugiyama KRT8 CYK8 NKRTEMENEFVLIKKDVDEAyMNKVELESRLEGLTDEINFL
P06239 Y505 GPS6|SIGNOR|iPTMNet|EPSD|PSP LCK PTFDyLRSVLEDFFtAtEGQyQPQP________________
P06241 Y531 GPS6|ELM|iPTMNet|EPSD|PSP FYN PTFEYLQSFLEDYFtAtEPQyQPGENL______________
P06733 S268 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 ASEFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyP
P06733 Y257 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 TDKVVIGMDVAASEFFRsGKyDLDFKsPDDPsRyIsPDQLA
P06733 Y270 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P06733 Y280 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 DFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDD
P06733 Y407 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GLCtGQIKTGAPCRSERLAKyNQLLRIEEELGsKAKFAGRN
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07237 Y94 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNGDTASPK
P07355 Y188 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D RKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVKRKGT
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07437 Y51 Sugiyama TUBB TUBB5 OK/SW-cl.56 DPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPG
P07686 Y547 Sugiyama HEXB HCC7 DRLTRHRCRMVERGIAAQPLyAGyCNHENM___________
P07814 Y1504 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 KPLCELQPGAKCVCGKNPAKyytLFGRsy____________
P07814 Y1505 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PLCELQPGAKCVCGKNPAKyytLFGRsy_____________
P07900 Y197 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA GEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIGyP
P07900 Y284 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEEEEKKDGDKKKKKKIKEKyIDQEELNKtKPIWtRNPDDI
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900 Y313 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P07900 Y492 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLR
P07900 Y493 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLRK
P07900 Y61 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA KEIFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLI
P07947 Y537 GPS6|EPSD|PSP YES1 YES PTFEYIQSFLEDYFTATEPQyQPGENL______________
P07948 Y508 GPS6|SIGNOR|ELM|iPTMNet|EPSD LYN JTK8 PTFDYLQsVLDDFytAtEGQyQQQP________________
P08238 Y192 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIGyP
P08238 Y276 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEEDDsGKDKKKKTKKIKEKyIDQEELNKtKPIWtRNPDDI
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238 Y472 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB sELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEsKE
P08238 Y484 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P08238 Y485 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB EMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRK
P08238 Y56 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEIFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDII
P08575 Y1218 SIGNOR PTPRC CD45 FQVVKALRKARPGMVSTFEQyQFLYDVIASTYPAQNGQVKK
P08631 Y411 EPSD|PSP HCK ASLVCKIADFGLARVIEDNEytAREGAKFPIKWTAPEAINF
P08631 Y522 iPTMNet HCK PTFEYIQSVLDDFYTAtEsQyQQQP________________
P09104 Y44 Sugiyama ENO2 LyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKGVLK
P09651 Y341 Sugiyama HNRNPA1 HNRPA1 QSSNFGPMKGGNFGGRssGPyGGGGQyFAKPRNQGGyGGss
P09651 Y347 Sugiyama HNRNPA1 HNRPA1 PMKGGNFGGRssGPyGGGGQyFAKPRNQGGyGGssssssyG
P09769 Y523 GPS6|SIGNOR|ELM|iPTMNet|EPSD FGR SRC2 PTFEYLQSFLEDYFTSAEPQyQPGDQT______________
P0CG38 Y1062 Sugiyama POTEI GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P0CG39 Y1025 Sugiyama POTEJ GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P10636 Y29 PSP MAPT MAPTL MTBT1 TAU EVMEDHAGTyGLGDRKDQGGytMHQDQEGDtDAGLKEsPLQ
P11047 Y352 Sugiyama LAMC1 LAMB2 tAEsASECLPCDCNGRsQECyFDPELyRSTGHGGHCTNCQD
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11940 Y194 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 KSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLFGKF
P11940 Y291 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 ERQTELKRKFEQMKQDRITRyQGVNLyVKNLDDGIDDERLR
P11940 Y297 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 KRKFEQMKQDRITRyQGVNLyVKNLDDGIDDERLRKEFsPF
P12004 Y249 Sugiyama PCNA MSADVPLVVEYKIADMGHLKyyLAPKIEDEEGs________
P12004 Y250 Sugiyama PCNA SADVPLVVEYKIADMGHLKyyLAPKIEDEEGs_________
P12277 Y125 Sugiyama CKB CKBB EHKTDLNPDNLQGGDDLDPNyVLssRVRTGRSIRGFCLPPH
P12277 Y39 Sugiyama CKB CKBB EFPDLSAHNNHMAKVLtPELyAELRAKSTPSGFTLDDVIQT
P12814 Y842 Sugiyama ACTN1 DTDTADQVMASFKILAGDKNyITMDELRRELPPDQAEyCIA
P12931 Y419 EPSD|PSP SRC SRC1 ENLVCKVADFGLARLIEDNEytARQGAKFPIKWTAPEAALy
P12931 Y530 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SRC SRC1 PTFEYLQAFLEDyFtstEPQyQPGENL______________
P13639 Y671 Sugiyama EEF2 EF2 CFGPDGTGPNILTDITKGVQyLNEIKDSVVAGFQWATKEGA
P13667 Y565 Sugiyama PDIA4 ERP70 ERP72 DVLIEFYAPWCGHCKQLEPVyNsLAKKYKGQKGLVIAKMDA
P13674 Y282 Sugiyama P4HA1 P4HA ASDDQSDQKTTPKKKGVAVDyLPERQKyEMLCRGEGIKMTP
P13929 Y44 Sugiyama ENO3 LHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKGVLK
P14314 Y106 Sugiyama PRKCSH G19P1 yIPSNRVNDGVCDCCDGtDEyNsGVICENtCKEKGRKEREs
P14625 Y258 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GNTLGRGTTITLVLKEEAsDyLELDTIKNLVKKYSQFINFP
P14625 Y429 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IKLYVRRVFITDDFHDMMPKyLNFVKGVVDsDDLPLNVsRE
P14625 Y539 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDItsLDQyVERMKEKQDKIyFMAGsSRKEAEssPFVERLL
P14649 S87 Sugiyama MYL6B MLC1SA EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK
P14649 Y86 Sugiyama MYL6B MLC1SA LEEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVL
P15259 Y92 Sugiyama PGAM2 PGAMM DGTDQMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEEQV
P15880 S249 Sugiyama RPS2 RPS4 CtAtLGNFAKATFDAISKTysyLtPDLWKEtVFtKsPyQEF
P15880 Y250 Sugiyama RPS2 RPS4 tAtLGNFAKATFDAISKTysyLtPDLWKEtVFtKsPyQEFt
P15941 Y1229 GPS6|EPSD MUC1 PUM yPtyHtHGRyVPPsstDRsPyEKVsAGNGGssLsytNPAVA
P16284 Y713 SIGNOR PECAM1 VQVSsAEsHKDLGKKDtEtVysEVRKAVPDAVEsRYsRtEG
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17987 S544 Sugiyama TCP1 CCT1 CCTA ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________
P17987 Y545 Sugiyama TCP1 CCT1 CCTA LRIDDLIKLHPESKDDKHGsyEDAVHsGALND_________
P18206 Y822 Sugiyama VCL KAVAGNIsDPGLQKsFLDsGyRILGAVAKVREAFQPQEPDF
P18615 Y133 Sugiyama NELFE RD RDBP sIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEA
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P18621 Y4 Sugiyama RPL17 _________________MVRysLDPENPtKsCKSRGSNLRV
P18669 S137 Sugiyama PGAM1 PGAMA CDABP0006 RsyDVPPPPMEPDHPFysNIsKDRRyADLtEDQLPsCEsLK
P18669 Y119 Sugiyama PGAM1 PGAMA CDABP0006 NKAETAAKHGEAQVKIWRRsyDVPPPPMEPDHPFysNIsKD
P18669 Y142 Sugiyama PGAM1 PGAMA CDABP0006 PPPPMEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIAR
P18669 Y92 Sugiyama PGAM1 PGAMA CDABP0006 DAIDQMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEAQV
P19105 Y155 Sugiyama MYL12A MLCB MRLC3 RLC DEEVDELyREAPIDKKGNFNyIEFtRILKHGAKDKDD____
P19338 T464 Sugiyama NCL KTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWsGE
P19338 Y462 Sugiyama NCL AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P20618 Y150 Sugiyama PSMB1 PSC5 FPYYVYNIIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSAS
P20618 Y158 Sugiyama PSMB1 PSC5 IGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLD
P21980 Y369 Sugiyama TGM2 PGYEGWQALDPTPQEKsEGtyCCGPVPVRAIKEGDLstKyD
P22234 Y22 Sugiyama PAICS ADE2 AIRC PAIS AtAEVLNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAG
P22314 Y55 Sugiyama UBA1 A1S9T UBE1 SVPTNGMAKNGsEADIDEGLysRQLyVLGHEAMKRLQTSSV
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23246 S491 Sugiyama SFPQ PSF QKEREtPPRFAQHGtFEyEysQRWKsLDEMEKQQREQVEKN
P23246 Y488 Sugiyama SFPQ PSF PMYQKEREtPPRFAQHGtFEyEysQRWKsLDEMEKQQREQV
P23246 Y490 Sugiyama SFPQ PSF YQKEREtPPRFAQHGtFEyEysQRWKsLDEMEKQQREQVEK
P23284 Y119 Sugiyama PPIB CYPB DFMIQGGDFtRGDGtGGKsIyGERFPDENFKLKHyGPGWVs
P23434 Y139 Sugiyama GCSH EVTEINEALAENPGLVNKSCyEDGWLIKMtLsNPsELDELM
P23528 Y140 Sugiyama CFL1 CFL SKDAIKKKLtGIKHELQANCyEEVKDRCTLAEKLGGsAVIs
P23528 Y68 Sugiyama CFL1 CFL ILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAt
P24752 Y214 Sugiyama ACAT1 ACAT MAT GsCAENTAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNE
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P25786 Y6 Sugiyama PSMA1 HC2 NU PROS30 PSC2 _______________MFRNQyDNDVtVWsPQGRIHQIEYAM
P26196 Y469 Sugiyama DDX6 HLR2 RCK IEEQLGTEIKPIPsNIDKSLyVAEyHsEPVEDEKP______
P26196 Y473 Sugiyama DDX6 HLR2 RCK LGTEIKPIPsNIDKSLyVAEyHsEPVEDEKP__________
P27348 Y149 Sugiyama YWHAQ LAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHPIRLG
P27348 Y48 Sugiyama YWHAQ AVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSIEQK
P27695 Y45 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 KSKTAAKKNDKEAAGEGPALyEDPPDQKtsPsGKPAtLKIC
P27797 Y109 Sugiyama CALR CRTC QTLVVQFTVKHEQNIDCGGGyVKLFPNSLDQTDMHGDSEYN
P27816 Y47 Sugiyama MAP4 AtLEAEAFDDVVGETVGKTDyIPLLDVDEKtGNsESKKKPC
P29401 Y481 Sugiyama TKT AANTKGICFIRTsRPENAIIyNNNEDFQVGQAKVVLKSKDD
P29692 Y26 Sugiyama EEF1D EF1D LAHEKIWFDKFKYDDAERRFyEQMNGPVAGAsRQENGAsVI
P30043 Y205 Sugiyama BLVRB FLR SCAN MLRCLttDEyDGHstyPsHQyQ___________________
P30085 Y49 Sugiyama CMPK1 CMK CMPK UCK UMK UMPK ytHLSAGELLRDERKNPDsQyGELIEKYIKEGKIVPVEITI
P30086 Y64 Sugiyama PEBP1 PBP PEBP tQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREW
P30101 Y100 Sugiyama PDIA3 ERP57 ERP60 GRP58 LAKVDCTANTNTCNKyGVsGyPtLKIFRDGEEAGAyDGPRt
P30101 Y115 Sugiyama PDIA3 ERP57 ERP60 GRP58 yGVsGyPtLKIFRDGEEAGAyDGPRtADGIVsHLKKQAGPA
P30101 Y67 Sugiyama PDIA3 ERP57 ERP60 GRP58 LMLVEFFAPWCGHCKRLAPEyEAAAtRLKGIVPLAKVDCTA
P30101 Y95 Sugiyama PDIA3 ERP57 ERP60 GRP58 KGIVPLAKVDCTANTNTCNKyGVsGyPtLKIFRDGEEAGAy
P31943 Y266 Sugiyama HNRNPH1 HNRPH HNRPH1 yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P31946 Y151 Sugiyama YWHAB LsEVAsGDNKQTtVsNsQQAyQEAFEIsKKEMQPTHPIRLG
P31946 Y50 Sugiyama YWHAB AVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P31947 Y151 Sugiyama SFN HME1 LAEVATGDDKKRIIDSARsAyQEAMDISKKEMPPTNPIRLG
P31947 Y48 Sugiyama SFN HME1 GAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsIEQK
P31948 Y354 Sugiyama STIP1 DVLKKCQQAEKILKEQERLAyINPDLALEEKNKGNECFQKG
P31948 Y41 Sugiyama STIP1 DDALQCysEAIKLDPHNHVLysNRsAAyAKKGDYQKAyEDG
P32969 Y180 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932 Y30 Sugiyama HSPA4 APG2 HSPH2 FQSCYVAVARAGGIETIANEysDRCtPACIsFGPKNRSIGA
P35222 Y654 GPS6|EPSD CTNNB1 CTNNB OK/SW-cl.35 PRO2286 EGATAPLTELLHsRNEGVAtyAAAVLFRMSEDKPQDyKKRL
P35222 Y86 GPS6|EPSD CTNNB1 CTNNB OK/SW-cl.35 PRO2286 WEQGFSQsFTQEQVADIDGQyAMTRAQRVRAAMFPEtLDEG
P36871 Y476 Sugiyama PGM1 GKQFSANDKVYtVEKADNFEysDPVDGsIsRNQGLRLIFTD
P37802 Y192 Sugiyama TAGLN2 KIAA0120 CDABP0035 NVIGLQMGtNRGAsQAGMtGyGMPRQIL_____________
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P38646 Y196 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 EtAENyLGHtAKNAVItVPAyFNDsQRQAtKDAGQIsGLNV
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P40261 Y11 Sugiyama NNMT __________MESGFTSKDTyLSHFNPRDYLEKYYKFGSRH
P40429 Y149 Sugiyama RPL13A LKPTRKFAYLGRLAHEVGWKyQAVtAtLEEKRKEKAKIHYR
P41240 Y116 Sugiyama CSK LyPPETGLFLVRESTNYPGDyTLCVSCDGKVEHYRIMYHAS
P41240 Y184 Sugiyama CSK CTRLIKPKVMEGTVAAQDEFyRSGWALNMKELKLLQTIGKG
P41240 Y214 Sugiyama CSK ELKLLQTIGKGEFGDVMLGDyRGNKVAVKCIKNDATAQAFL
P41240 Y263 Sugiyama CSK LRHSNLVQLLGVIVEEKGGLyIVTEyMAKGSLVDYLRSRGR
P41240 Y268 Sugiyama CSK LVQLLGVIVEEKGGLyIVTEyMAKGSLVDYLRSRGRSVLGG
P41240 Y304 SIGNOR|iPTMNet CSK SVLGGDCLLKFSLDVCEAMEyLEGNNFVHRDLAARNVLVSE
P41240 Y416 Sugiyama CSK VPRVEKGYKMDAPDGCPPAVyEVMKNCWHLDAAMRPSFLQL
P41240 Y64 Sugiyama CSK DPNWYKAKNKVGREGIIPANyVQKREGVKAGTKLSLMPWFH
P41567 Y30 Sugiyama EIF1 SUI1 FDPFADAsKGDDLLPAGTEDyIHIRIQQRNGRKtLttVQGI
P47712 Y535 Sugiyama PLA2G4A CPLA2 PLA2G4 sFDDDELDAAVADPDEFERIyEPLDVKSKKIHVVDSGLTFN
P47756 Y59 Sugiyama CAPZB LLSSVDQPLKIARDKVVGKDyLLCDyNRDGDSyRsPWSNKy
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49023 Y40 iPTMNet PXN KRPVFLSEETPySYPTGNHTyQEIAVPPPVPPPPSSEALNG
P49023 Y88 iPTMNet PXN QWQPSSSRFIHQQPQsssPVyGssAKtssVsNPQDsVGsPC
P49207 Y34 Sugiyama RPL34 NtASNKTRLSRTPGNRIVyLytKKVGKAPKSACGVCPGRLR
P49327 Y2034 Sugiyama FASN FAS DYFVVFSSVSCGRGNAGQsNyGFANsAMERICEKRRHEGLP
P50897 Y264 Sugiyama PPT1 CLN1 PPT FGFYRsGQAKEtIPLQEtsLytQDRLGLKEMDNAGQLVFLA
P50990 Y30 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 GFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTTRTAYGPN
P50991 Y269 Sugiyama CCT4 CCTD SRB IQFCLSAPKTDMDNQIVVSDyAQMDRVLREERAYILNLVKQ
P51858 Y66 Sugiyama HDGF HMG1L2 QVFFFGTHETAFLGPKDLFPyEEsKEKFGKPNKRKGFsEGL
P51965 Y77 Sugiyama UBE2E1 UBCH6 ADITLDPPPNCSAGPKGDNIyEWRSTILGPPGSVYEGGVFF
P52209 Y137 Sugiyama PGD PGDH KAKGILFVGsGVsGGEEGARyGPSLMPGGNKEAWPHIKTIF
P54577 Y289 Sugiyama YARS1 YARS FPLKSEFVILRDEKWGGNKTytAyVDLEKDFAAEVVHPGDL
P54577 Y292 Sugiyama YARS1 YARS KSEFVILRDEKWGGNKTytAyVDLEKDFAAEVVHPGDLKNS
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55060 Y369 Sugiyama CSE1L CAS XPO2 VPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAACDL
P55209 Y106 Sugiyama NAP1L1 NRP VKCAQIEAKFyEEVHDLERKyAVLyQPLFDKRFEIINAIYE
P55209 Y110 Sugiyama NAP1L1 NRP QIEAKFyEEVHDLERKyAVLyQPLFDKRFEIINAIYEPTEE
P55795 Y266 Sugiyama HNRNPH2 FTP3 HNRPH2 YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60228 Y445 Sugiyama EIF3E EIF3S6 INT6 KLNQNSRSEAPNWAtQDsGFy____________________
P60660 S30 Sugiyama MYL6 AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK
P60660 Y29 Sugiyama MYL6 TAEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVL
P60660 Y86 Sugiyama MYL6 DFEHFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMG
P60660 Y89 Sugiyama MYL6 HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 Y198 Sugiyama ACTB LDLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCy
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y362 Sugiyama ACTB GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P60842 Y197 Sugiyama EIF4A1 DDX2A EIF4A KMFVLDEADEMLsRGFKDQIyDIFQKLNsNtQVVLLSATMP
P61081 Y172 Sugiyama UBE2M UBC12 VLQNNRRLFEQNVQRSMRGGyIGstyFERCLK_________
P61081 Y177 Sugiyama UBE2M UBC12 RRLFEQNVQRSMRGGyIGstyFERCLK______________
P61221 Y594 Sugiyama ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40 RPRINKLNsIKDVEQKKsGNyFFLDD_______________
P61247 Y256 Sugiyama RPS3A FTE1 MFTL sssGKAtGDEtGAKVERADGyEPPVQEsV____________
P61353 Y85 Sugiyama RPL27 RSKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPA
P61604 Y100 Sugiyama HSPE1 KVVLDDKDyFLFRDGDILGKyVD__________________
P61604 Y76 Sugiyama HSPE1 KGGEIQPVsVKVGDKVLLPEyGGtKVVLDDKDyFLFRDGDI
P61604 Y88 Sugiyama HSPE1 GDKVLLPEyGGtKVVLDDKDyFLFRDGDILGKyVD______
P61978 Y72 Sugiyama HNRNPK HNRPK KNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISA
P61981 Y49 Sugiyama YWHAG NVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P62081 Y177 Sugiyama RPS7 HLDKAQQNNVEHKVEtFsGVyKKLTGKDVNFEFPEFQL___
P62191 Y184 Sugiyama PSMC1 MDDTDPLVTVMKVEKAPQETyADIGGLDNQIQEIKESVELP
P62191 Y439 Sugiyama PSMC1 FKKSKENVLyKKQEGtPEGLyL___________________
P62249 Y115 Sugiyama RPS16 YYQKYVDEASKKEIKDILIQyDRtLLVADPRRCESKKFGGP
P62258 Y152 Sugiyama YWHAE LAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHPIRLG
P62258 Y49 Sugiyama YWHAE KVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssIEQK
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62280 Y55 Sugiyama RPS11 RYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILsG
P62495 Y345 Sugiyama ETF1 ERF1 RF1 SUP45L1 NLDIMRYVLHCQGTEEEKILyLTPEQEKDKSHFTDKETGQE
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62750 Y144 Sugiyama RPL23A VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P62826 Y146 Sugiyama RAN ARA24 OK/SW-cl.81 IKDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLAR
P62906 Y11 Sugiyama RPL10A NEDD6 __________MSSKVsRDtLyEAVREVLHGNQRKRRKFLET
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P63104 Y149 Sugiyama YWHAZ LAEVAAGDDKKGIVDQsQQAyQEAFEIsKKEMQPTHPIRLG
P63104 Y48 Sugiyama YWHAZ sVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssIEQK
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 Y198 Sugiyama ACTG1 ACTG LDLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCy
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y362 Sugiyama ACTG1 ACTG GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 Y72 Sugiyama YBX1 NSEP1 YB1 KKVIATKVLGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIK
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q00610 Y883 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 EARIHEGCEEPAtHNALAKIyIDsNNNPERFLRENPyyDsR
Q00839 Y257 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 QKGGDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVE
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01130 Y44 Sugiyama SRSF2 SFRS2 RtsPDtLRRVFEKYGRVGDVyIPRDRYTKESRGFAFVRFHD
Q02878 Y115 Sugiyama RPL6 TXREB1 PVGGDKNGGTRVVKLRKMPRyyPtEDVPRKLLSHGKKPFSQ
Q04837 Y73 Sugiyama SSBP1 SSBP PVTIFSLATNEMWRsGDsEVyQLGDVsQKTTWHRISVFRPG
Q04917 Y49 Sugiyama YWHAH YWHA1 AVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSIEQK
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q13263 Y133 Sugiyama TRIM28 KAP1 RNF96 TIF1B TVVDCPVCKQQCFSKDIVENyFMRDsGsKAATDAQDANQCC
Q13263 Y242 Sugiyama TRIM28 KAP1 RNF96 TIF1B ESCDTLTCRDCQLNAHKDHQyQFLEDAVRNQRKLLAsLVKR
Q13310 Y194 Sugiyama PABPC4 APP1 PABP4 KSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELFsQF
Q13442 S19 Sugiyama PDAP1 HASPP28 __MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13561 Y6 Sugiyama DCTN2 DCTN50 _______________MADPKyADLPGIARNEPDVYETSDLP
Q13765 Y120 Sugiyama NACA HSD48 KNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAAA
Q14152 Y697 Sugiyama EIF3A EIF3S10 KIAA0139 LEKEKKELQERLKNQEKKIDyFERAKRLEEIPLIKSAYEEQ
Q14247 Y334 Sugiyama CTTN EMS1 KDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKtsNIRANF
Q14247 Y446 Sugiyama CTTN EMS1 sFKAELsyRGPVsGtEPEPVysMEAADyREASSQQGLAYAT
Q14257 Y311 Sugiyama RCN2 ERC55 NPDLFLtsEAtDyGRQLHDDyFyHDEL______________
Q14257 Y313 Sugiyama RCN2 ERC55 DLFLtsEAtDyGRQLHDDyFyHDEL________________
Q14568 Y283 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 sDEEEEKKDGDKKKKKTKEKyIDQEELNKTKPIWTRNPDDI
Q15056 Y101 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 FKGFCyVEFDEVDsLKEALtyDGALLGDRsLRVDIAEGRKQ
Q15181 Y169 Sugiyama PPA1 IOPPP PP EGETDWKVIAINVDDPDAANyNDINDVKRLKPGYLEATVDW
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q15427 Y16 Sugiyama SF3B4 SAP49 _____MAAGPISERNQDAtVyVGGLDEKVSEPLLWELFLQA
Q15527 Y123 Sugiyama SURF2 GRRYQRALCKYEECQKQGVEyVPACLVHRRRRREDQMDGDG
Q15785 Y25 Sugiyama TOMM34 URCC3 FPDsVEELRAAGNESFRNGQyAEASALyGRALRVLQAQGss
Q15819 Y143 Sugiyama UBE2V2 MMS2 UEV2 RRLMMSKENMKLPQPPEGQtyNN__________________
Q16719 Y441 Sugiyama KYNU RGVVCDKRNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsA
Q16719 Y448 Sugiyama KYNU RNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsAETKN___
Q16719 Y86 Sugiyama KYNU ENAIYFLGNSLGLQPKMVKtyLEEELDKWAKIAAYGHEVGK
Q4VXU2 Y291 Sugiyama PABPC1L C20orf119 ERQNELKRRFEQMKQDRLRRyQGVNLyVKNLDDSIDDDKLR
Q4VXU2 Y297 Sugiyama PABPC1L C20orf119 KRRFEQMKQDRLRRyQGVNLyVKNLDDSIDDDKLRKEFSPY
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF6 Y167 Sugiyama HSP90AB4P GEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIGCL
Q58FF6 Y32 Sugiyama HSP90AB4P KEIFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDII
Q58FF7 Y171 Sugiyama HSP90AB3P HSP90BC GEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIGyP
Q58FF7 Y56 Sugiyama HSP90AB3P HSP90BC EEIFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDII
Q58FF8 Y198 Sugiyama HSP90AB2P HSP90BB DEEDDsGKDKKKKTKKIKEKyIDQEELNKTKPIWTRNTEDI
Q58FF8 Y260 Sugiyama HSP90AB2P HSP90BB VRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVW
Q58FF8 Y261 Sugiyama HSP90AB2P HSP90BB RYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVWK
Q58FF8 Y56 Sugiyama HSP90AB2P HSP90BB KEIFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDII
Q58FG0 Y177 Sugiyama HSP90AA5P HSP90AE GQLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQ
Q58FG0 Y178 Sugiyama HSP90AA5P HSP90AE QLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQK
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6S8J3 Y1062 Sugiyama POTEE A26C1A POTE2 GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q7KZF4 Y476 Sugiyama SND1 TDRD11 SKGLATVIRYRQDDDQRssHyDELLAAEARAIKNGKGLHSK
Q8N0Y7 S137 Sugiyama PGAM4 PGAM3 RsyDVPPPPMEPDHPFysNIsKDRRYADLTEDQLPSYESPK
Q8N0Y7 Y119 Sugiyama PGAM4 PGAM3 NKAETAAKHGEAQVKIWRRsyDVPPPPMEPDHPFysNIsKD
Q8N0Y7 Y92 Sugiyama PGAM4 PGAM3 DAIDQMWLPVVRTWRLNERHyGGLtGLNKAETAAKHGEAQV
Q8NBS9 T248 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 EQLALGLEHSETVKIGKVDCtQHyELCsGNQVRGyPtLLWF
Q8NI22 Y135 Sugiyama MCFD2 SDNSF DELINIIDGVLRDDDKNNDGyIDyAEFAKSLQ_________
Q8NI22 Y138 Sugiyama MCFD2 SDNSF INIIDGVLRDDDKNNDGyIDyAEFAKSLQ____________
Q8TEW0 S386 Sugiyama PARD3 PAR3 PAR3A YEQLSQSEKNNyyssRFsPDsQyIDNRSVNSAGLHTVQRAP
Q92598 Y641 Sugiyama HSPH1 HSP105 HSP110 KIAA0201 MIMQDKLEKERNDAKNAVEEyVyEFRDKLCGPYEKFICEQD
Q92598 Y643 Sugiyama HSPH1 HSP105 HSP110 KIAA0201 MQDKLEKERNDAKNAVEEyVyEFRDKLCGPYEKFICEQDHQ
Q969T4 Y91 Sugiyama UBE2E3 UBCE4 UBCH9 AEITLDPPPNCSAGPKGDNIyEWRSTILGPPGSVYEGGVFF
Q96LR5 Y85 Sugiyama UBE2E2 UBCH8 AEITLDPPPNCSAGPKGDNIyEWRSTILGPPGSVYEGGVFF
Q99733 Y95 Sugiyama NAP1L4 NAP2 VRCAHIEAKFyEEVHDLERKyAALyQPLFDKRREFItGDVE
Q99733 Y99 Sugiyama NAP1L4 NAP2 HIEAKFyEEVHDLERKyAALyQPLFDKRREFItGDVEPtDA
Q9BQE3 Y432 Sugiyama TUBA1C TUBA6 GMEEGEFSEAREDMAALEKDyEEVGADsADGEDEGEEy___
Q9BRL6 Y44 Sugiyama SRSF8 SFRS2B SRP46 RtsPDsLRRVFEKYGRVGDVyIPREPHTKAPRGFAFVRFHD
Q9BY32 Y45 Sugiyama ITPA C20orf37 My049 OK/SW-cl.9 QILGDKFPCTLVAQKIDLPEyQGEPDEIsIQKCQEAVRQVQ
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BYX7 Y362 Sugiyama POTEKP ACTBL3 FKSG30 GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q9HB07 Y189 Sugiyama MYG1 C12orf10 VEEVDAVDNGISQWAEGEPRyALttTLsARVARLNPTWNHP
Q9NP74 Y174 Sugiyama PALMD C1orf11 PALML RLRKEINEEKEDDEQNRKALyAMEIKVEKDLKTGESTVLSs
Q9NVS9 Y256 Sugiyama PNPO LPtGDsPLGPMTHRGEEDWLyERLAP_______________
Q9UBR2 Y76 Sugiyama CTSZ YLSPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHA
Q9UI15 Y192 Sugiyama TAGLN3 NP25 NVIGLQMGSNKGAsQAGMtGyGMPRQIM_____________
Q9UMX5 Y65 Sugiyama NENF CIR2 SPUF RLFtEEELARYGGEEEDQPIyLAVKGVVFDVtSGKEFYGRG
Q9Y2B0 Y71 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEICDRMKE
Q9Y2T7 Y107 Sugiyama YBX2 CSDA3 MSY2 KPVLAIQVLGTVKWFNVRNGyGFINRNDtKEDVFVHQtAIK
Q9Y3D8 Y31 Sugiyama AK6 CINAP AD-004 CGI-137 TPGVGKTTLGKELASKSGLKyINVGDLAREEQLYDGYDEEY
Q9Y3F4 T109 Sugiyama STRAP MAWD UNRIP VSGDELMTLAHKHIVKtVDFtQDSNyLLtGGQDKLLRIYDL
Q9Y4L1 Y759 Sugiyama HYOU1 GRP170 HSPH4 ORP150 AANsLEAFIFEtQDKLyQPEyQEVsTEEQREEISGKLSAAS
Q9Y639 Y216 Sugiyama NPTN SDFR1 SDR1 KNASNMEYRINKPRAEDsGEyHCVyHFVsAPKANATIEVKA
Q9Y639 Y220 Sugiyama NPTN SDFR1 SDR1 NMEYRINKPRAEDsGEyHCVyHFVsAPKANATIEVKAAPDI
Q9Y696 Y244 Sugiyama CLIC4 AysRDEFtNtCPsDKEVEIAysDVAKRLTK___________
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.793766e-14 13.108 0 0
Packaging Of Telomere Ends R-HSA-171306 2.161604e-13 12.665 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.161604e-13 12.665 0 0
DNA methylation R-HSA-5334118 4.051204e-13 12.392 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.726664e-13 12.012 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.409539e-12 11.851 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.281975e-12 11.892 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.180145e-12 11.662 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.180145e-12 11.662 0 0
PRC2 methylates histones and DNA R-HSA-212300 3.611778e-12 11.442 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 4.606759e-12 11.337 0 0
Cleavage of the damaged purine R-HSA-110331 4.606759e-12 11.337 0 0
Depurination R-HSA-73927 5.842549e-12 11.233 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.247669e-12 11.204 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 7.545742e-12 11.122 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.622347e-12 11.118 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.247936e-12 11.034 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.247936e-12 11.034 0 0
HDACs deacetylate histones R-HSA-3214815 1.090228e-11 10.962 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.154699e-11 10.938 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.154699e-11 10.938 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.774936e-11 10.751 0 0
Depyrimidination R-HSA-73928 1.774936e-11 10.751 0 0
Defective pyroptosis R-HSA-9710421 2.185918e-11 10.660 0 0
Nucleosome assembly R-HSA-774815 3.274125e-11 10.485 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.274125e-11 10.485 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.610001e-11 10.442 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.983291e-11 10.400 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.830114e-11 10.234 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.205192e-11 10.207 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 9.144363e-11 10.039 0 0
Meiotic recombination R-HSA-912446 1.005843e-10 9.997 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.413986e-10 9.850 0 0
Meiotic synapsis R-HSA-1221632 1.423921e-10 9.847 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.413986e-10 9.850 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.628708e-10 9.788 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.686615e-10 9.773 0 0
Cell-Cell communication R-HSA-1500931 2.535360e-10 9.596 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.815066e-10 9.551 0 0
Cell-cell junction organization R-HSA-421270 2.940117e-10 9.532 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.229170e-10 9.491 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.773817e-10 9.423 0 0
RNA Polymerase I Transcription R-HSA-73864 3.662736e-10 9.436 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.399530e-10 9.357 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.548285e-10 9.342 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.734818e-10 9.325 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.082871e-10 9.216 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.937280e-10 9.226 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.749897e-10 9.171 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 7.099797e-10 9.149 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 7.099797e-10 9.149 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.768546e-10 9.110 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.711235e-10 9.060 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.711235e-10 9.060 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.711235e-10 9.060 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.220460e-10 9.035 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.220460e-10 9.035 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.053078e-09 8.978 0 0
DNA Double Strand Break Response R-HSA-5693606 1.209027e-09 8.918 0 0
Cell junction organization R-HSA-446728 1.381539e-09 8.860 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.808655e-09 8.743 0 0
Adherens junctions interactions R-HSA-418990 2.023073e-09 8.694 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.957205e-09 8.708 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.711534e-09 8.567 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.017673e-09 8.520 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.482272e-09 8.458 0 0
Mitotic Prophase R-HSA-68875 5.061609e-09 8.296 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.949783e-09 8.158 0 0
Amyloid fiber formation R-HSA-977225 6.949783e-09 8.158 0 0
Meiosis R-HSA-1500620 1.084930e-08 7.965 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.144324e-08 7.941 0 0
Developmental Biology R-HSA-1266738 1.277256e-08 7.894 0 0
Gene Silencing by RNA R-HSA-211000 1.315956e-08 7.881 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.576855e-08 7.802 0 0
Diseases of programmed cell death R-HSA-9645723 1.659541e-08 7.780 0 0
Base Excision Repair R-HSA-73884 2.037939e-08 7.691 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.242161e-08 7.649 0 0
Signal Transduction R-HSA-162582 3.754908e-08 7.425 1 0
ESR-mediated signaling R-HSA-8939211 4.047168e-08 7.393 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.777130e-08 7.321 1 0
Telomere Maintenance R-HSA-157579 4.870158e-08 7.312 0 0
HATs acetylate histones R-HSA-3214847 5.846668e-08 7.233 0 0
Cellular Senescence R-HSA-2559583 6.803659e-08 7.167 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.638589e-08 7.117 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.203017e-07 6.920 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.939632e-07 6.712 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.235296e-07 6.651 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.377124e-07 6.471 0 0
Homology Directed Repair R-HSA-5693538 3.521316e-07 6.453 0 0
Chromosome Maintenance R-HSA-73886 4.381581e-07 6.358 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.708485e-07 6.327 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.053566e-07 6.296 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.988610e-07 6.223 1 0
DNA Replication R-HSA-69306 6.203224e-07 6.207 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.872803e-07 6.163 1 0
G2/M Checkpoints R-HSA-69481 7.147037e-07 6.146 0 0
HCMV Late Events R-HSA-9610379 7.879715e-07 6.103 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.741240e-07 6.058 0 0
Reproduction R-HSA-1474165 9.338209e-07 6.030 0 0
HCMV Early Events R-HSA-9609690 1.088283e-06 5.963 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.643740e-06 5.784 0 0
Signaling by NOTCH R-HSA-157118 1.601659e-06 5.795 0 0
HCMV Infection R-HSA-9609646 2.468428e-06 5.608 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.807704e-06 5.552 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.897653e-06 5.409 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.186050e-06 5.378 0 0
Protein ubiquitination R-HSA-8852135 5.087225e-06 5.294 0 0
G alpha (12/13) signalling events R-HSA-416482 6.570822e-06 5.182 0 0
Epigenetic regulation of gene expression R-HSA-212165 8.206556e-06 5.086 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.167994e-05 4.933 0 0
Ub-specific processing proteases R-HSA-5689880 1.225320e-05 4.912 0 0
Signaling by ERBB2 R-HSA-1227986 1.318568e-05 4.880 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.947311e-05 4.711 0 0
Adaptive Immune System R-HSA-1280218 2.098554e-05 4.678 1 0
Chromatin modifying enzymes R-HSA-3247509 3.237843e-05 4.490 0 0
Co-inhibition by PD-1 R-HSA-389948 4.028708e-05 4.395 1 1
RAF/MAP kinase cascade R-HSA-5673001 4.941210e-05 4.306 1 0
Regulation of KIT signaling R-HSA-1433559 5.523819e-05 4.258 0 0
Chromatin organization R-HSA-4839726 5.586017e-05 4.253 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.852554e-05 4.233 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.183491e-05 4.209 1 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.866875e-05 4.163 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 7.291087e-05 4.137 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 7.291087e-05 4.137 0 0
NRAGE signals death through JNK R-HSA-193648 9.202292e-05 4.036 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 9.971708e-05 4.001 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.072409e-04 3.970 0 0
Immune System R-HSA-168256 1.524810e-04 3.817 1 0
Regulation of signaling by CBL R-HSA-912631 1.657645e-04 3.781 0 0
Activation of TRKA receptors R-HSA-187015 2.074262e-04 3.683 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.587419e-04 3.587 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.669577e-04 3.574 0 0
MAPK family signaling cascades R-HSA-5683057 2.656293e-04 3.576 1 0
Generic Transcription Pathway R-HSA-212436 2.799286e-04 3.553 0 0
Disease R-HSA-1643685 2.616325e-04 3.582 1 0
PIP3 activates AKT signaling R-HSA-1257604 2.394915e-04 3.621 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.590764e-04 3.587 0 0
Gene expression (Transcription) R-HSA-74160 2.877163e-04 3.541 0 0
Deubiquitination R-HSA-5688426 2.895474e-04 3.538 0 0
Signaling by SCF-KIT R-HSA-1433557 2.921297e-04 3.534 0 0
Signaling by KIT in disease R-HSA-9669938 2.966890e-04 3.528 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.966890e-04 3.528 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.966890e-04 3.528 0 0
RNA Polymerase II Transcription R-HSA-73857 2.985045e-04 3.525 0 0
Cell Cycle Checkpoints R-HSA-69620 3.170892e-04 3.499 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.239574e-04 3.490 0 0
Cell Cycle, Mitotic R-HSA-69278 3.299886e-04 3.482 0 0
Developmental Cell Lineages R-HSA-9734767 3.678952e-04 3.434 0 0
Deadenylation of mRNA R-HSA-429947 3.843025e-04 3.415 0 0
Parasite infection R-HSA-9664407 4.173161e-04 3.380 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.173161e-04 3.380 0 0
Leishmania phagocytosis R-HSA-9664417 4.173161e-04 3.380 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.344065e-04 3.362 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.509266e-04 3.259 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.721241e-04 3.173 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 6.721241e-04 3.173 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.483171e-04 3.261 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.483171e-04 3.261 0 0
Signaling by NTRKs R-HSA-166520 5.994028e-04 3.222 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.819928e-04 3.166 0 0
Interleukin-2 signaling R-HSA-9020558 5.509266e-04 3.259 0 0
M Phase R-HSA-68886 6.357865e-04 3.197 0 0
PECAM1 interactions R-HSA-210990 5.509266e-04 3.259 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.819928e-04 3.166 0 0
Infectious disease R-HSA-5663205 6.035197e-04 3.219 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.091025e-04 3.092 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 8.091025e-04 3.092 0 0
Signaling by LTK R-HSA-9842663 8.091025e-04 3.092 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.122897e-04 3.090 0 0
Signaling by WNT R-HSA-195721 9.519255e-04 3.021 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 9.546450e-04 3.020 0 0
Viral Infection Pathways R-HSA-9824446 9.971095e-04 3.001 0 0
Integrin signaling R-HSA-354192 1.015885e-03 2.993 1 1
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.219743e-03 2.914 0 0
Cellular responses to stimuli R-HSA-8953897 1.237768e-03 2.907 0 0
Cellular responses to stress R-HSA-2262752 1.298680e-03 2.886 0 0
Erythropoietin activates RAS R-HSA-9027284 1.322267e-03 2.879 0 0
Signalling to ERKs R-HSA-187687 1.331698e-03 2.876 0 0
TRKA activation by NGF R-HSA-187042 1.480785e-03 2.830 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.556965e-03 2.808 0 0
Axon guidance R-HSA-422475 1.774385e-03 2.751 0 0
Signaling by ALK R-HSA-201556 1.851631e-03 2.732 0 0
Regulation of gap junction activity R-HSA-191650 2.116837e-03 2.674 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.116837e-03 2.674 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.116837e-03 2.674 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.116837e-03 2.674 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.158009e-03 2.666 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.869178e-03 2.542 0 0
DAP12 interactions R-HSA-2172127 2.872420e-03 2.542 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.872420e-03 2.542 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.872420e-03 2.542 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.073462e-03 2.512 1 0
Signalling to RAS R-HSA-167044 3.201430e-03 2.495 0 0
Nervous system development R-HSA-9675108 3.220092e-03 2.492 0 0
Death Receptor Signaling R-HSA-73887 3.348112e-03 2.475 0 0
Cell Cycle R-HSA-1640170 3.360218e-03 2.474 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.503958e-03 2.455 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.556342e-03 2.449 0 0
NGF-independant TRKA activation R-HSA-187024 3.708847e-03 2.431 0 0
Co-stimulation by CD28 R-HSA-389356 3.733826e-03 2.428 0 0
GPER1 signaling R-HSA-9634597 3.733826e-03 2.428 0 0
DNA Repair R-HSA-73894 3.756715e-03 2.425 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.761591e-03 2.322 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.686326e-03 2.245 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.711422e-03 2.243 0 0
Signaling by EGFR R-HSA-177929 5.950060e-03 2.225 1 0
EPH-Ephrin signaling R-HSA-2682334 5.952965e-03 2.225 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.195856e-03 2.208 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.711501e-03 2.173 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.860828e-03 2.164 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.860828e-03 2.164 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.860828e-03 2.164 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.966633e-03 2.157 0 0
Regulation of beta-cell development R-HSA-186712 6.966633e-03 2.157 0 0
Signaling by Erythropoietin R-HSA-9006335 7.262572e-03 2.139 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.262572e-03 2.139 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.262572e-03 2.139 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.839694e-03 2.106 0 0
DAP12 signaling R-HSA-2424491 7.839694e-03 2.106 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.105939e-03 2.091 0 0
Downstream signal transduction R-HSA-186763 8.443141e-03 2.073 0 0
Semaphorin interactions R-HSA-373755 8.491922e-03 2.071 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 8.491922e-03 2.071 0 0
Signaling by PTK6 R-HSA-8848021 8.491922e-03 2.071 0 0
IGF1R signaling cascade R-HSA-2428924 8.904679e-03 2.050 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.330326e-03 2.030 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 9.444524e-03 2.025 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.087439e-02 1.964 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.105473e-02 1.956 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.105473e-02 1.956 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.105473e-02 1.956 0 0
KIT mutants bind TKIs R-HSA-9669921 1.105473e-02 1.956 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.105473e-02 1.956 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.105473e-02 1.956 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.105473e-02 1.956 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.105473e-02 1.956 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.105473e-02 1.956 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.105473e-02 1.956 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.105473e-02 1.956 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.105473e-02 1.956 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.105473e-02 1.956 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.105473e-02 1.956 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.105473e-02 1.956 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.105473e-02 1.956 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.105473e-02 1.956 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.105473e-02 1.956 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.105473e-02 1.956 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.105473e-02 1.956 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.105473e-02 1.956 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.105473e-02 1.956 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.105473e-02 1.956 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.105473e-02 1.956 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.105473e-02 1.956 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.105473e-02 1.956 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.105473e-02 1.956 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.105473e-02 1.956 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.105473e-02 1.956 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.105473e-02 1.956 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.105473e-02 1.956 0 0
RAF activation R-HSA-5673000 1.112496e-02 1.954 0 0
MET activates RAS signaling R-HSA-8851805 1.399935e-02 1.854 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.399935e-02 1.854 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.746399e-02 1.758 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.781249e-02 1.749 1 1
MAP2K and MAPK activation R-HSA-5674135 1.781249e-02 1.749 1 1
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.746399e-02 1.758 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.342337e-02 1.872 1 1
GPVI-mediated activation cascade R-HSA-114604 1.262955e-02 1.899 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.399935e-02 1.854 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 1.520489e-02 1.818 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.520489e-02 1.818 0 0
Interleukin-2 family signaling R-HSA-451927 1.597243e-02 1.797 0 0
Signal regulatory protein family interactions R-HSA-391160 1.746399e-02 1.758 0 0
RUNX2 regulates bone development R-HSA-8941326 1.262955e-02 1.899 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.432734e-02 1.844 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.931859e-02 1.714 0 0
DCC mediated attractive signaling R-HSA-418885 1.931859e-02 1.714 0 0
Signaling by FGFR4 R-HSA-5654743 1.976577e-02 1.704 0 0
Parasitic Infection Pathways R-HSA-9824443 2.012660e-02 1.696 0 0
Leishmania infection R-HSA-9658195 2.012660e-02 1.696 0 0
Signaling by VEGF R-HSA-194138 2.079989e-02 1.682 0 0
Prolonged ERK activation events R-HSA-169893 2.125204e-02 1.673 0 0
Signaling by FGFR3 R-HSA-5654741 2.183261e-02 1.661 0 0
Activation and oligomerization of BAK protein R-HSA-111452 2.198793e-02 1.658 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.198793e-02 1.658 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.198793e-02 1.658 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.253074e-02 1.647 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.290867e-02 1.640 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.290867e-02 1.640 1 1
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.290867e-02 1.640 1 1
Signaling by RAS mutants R-HSA-6802949 2.290867e-02 1.640 1 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.534775e-02 1.596 0 0
Degradation of CDH1 R-HSA-9766229 2.630729e-02 1.580 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.750621e-02 1.561 0 0
GAB1 signalosome R-HSA-180292 2.750621e-02 1.561 1 1
Nephron development R-HSA-9831926 2.750621e-02 1.561 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.750621e-02 1.561 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.784970e-02 1.555 0 0
FCGR activation R-HSA-2029481 2.871634e-02 1.542 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.203508e-02 1.494 0 0
Formation of definitive endoderm R-HSA-9823730 3.203508e-02 1.494 0 0
Translation initiation complex formation R-HSA-72649 3.253783e-02 1.488 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.257662e-02 1.487 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.280092e-02 1.484 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.280092e-02 1.484 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.280092e-02 1.484 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.280092e-02 1.484 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.280092e-02 1.484 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.328886e-02 1.478 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 3.440188e-02 1.463 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.522673e-02 1.453 0 0
Signaling by FGFR1 R-HSA-5654736 3.522673e-02 1.453 0 0
Regulation of CDH1 Function R-HSA-9764561 3.661296e-02 1.436 0 0
Dectin-2 family R-HSA-5621480 3.661296e-02 1.436 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 3.683457e-02 1.434 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.683457e-02 1.434 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.683457e-02 1.434 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.723593e-02 1.429 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.802692e-02 1.420 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.349502e-02 1.362 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 4.349502e-02 1.362 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 4.349502e-02 1.362 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 4.349502e-02 1.362 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.349502e-02 1.362 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.349502e-02 1.362 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.349502e-02 1.362 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.349502e-02 1.362 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.349502e-02 1.362 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.349502e-02 1.362 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.349502e-02 1.362 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.349502e-02 1.362 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.349502e-02 1.362 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.349502e-02 1.362 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.364082e-02 1.360 0 0
Signaling by PDGF R-HSA-186797 4.395739e-02 1.357 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 4.451083e-02 1.352 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.451083e-02 1.352 0 0
Tight junction interactions R-HSA-420029 4.719008e-02 1.326 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.726440e-02 1.325 1 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.783685e-02 1.320 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.868965e-02 1.313 1 1
MET activates PTK2 signaling R-HSA-8874081 4.992688e-02 1.302 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.992688e-02 1.302 0 0
FCERI mediated MAPK activation R-HSA-2871796 5.062696e-02 1.296 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 5.271963e-02 1.278 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.271963e-02 1.278 0 0
PLC-gamma1 signalling R-HSA-167021 5.407154e-02 1.267 0 0
MET interacts with TNS proteins R-HSA-8875513 5.407154e-02 1.267 0 0
MET activates PTPN11 R-HSA-8865999 5.407154e-02 1.267 0 0
Invadopodia formation R-HSA-8941237 5.407154e-02 1.267 0 0
Signalling to STAT3 R-HSA-198745 5.407154e-02 1.267 0 0
MET activates STAT3 R-HSA-8875791 5.407154e-02 1.267 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 6.453175e-02 1.190 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 6.453175e-02 1.190 0 0
NTRK2 activates RAC1 R-HSA-9032759 7.487693e-02 1.126 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 7.487693e-02 1.126 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 8.510834e-02 1.070 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 8.510834e-02 1.070 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.510834e-02 1.070 0 0
Phosphorylation of Emi1 R-HSA-176417 8.510834e-02 1.070 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 8.510834e-02 1.070 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 9.522722e-02 1.021 0 0
Erythropoietin activates STAT5 R-HSA-9027283 9.522722e-02 1.021 0 0
STAT5 Activation R-HSA-9645135 9.522722e-02 1.021 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 1.052348e-01 0.978 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.052348e-01 0.978 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.052348e-01 0.978 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.151323e-01 0.939 0 0
Formation of annular gap junctions R-HSA-196025 1.151323e-01 0.939 0 0
MET receptor recycling R-HSA-8875656 1.151323e-01 0.939 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.151323e-01 0.939 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.370834e-02 1.132 0 0
MET promotes cell motility R-HSA-8875878 9.005729e-02 1.045 0 0
Signaling by MET R-HSA-6806834 7.583131e-02 1.120 0 0
FLT3 Signaling R-HSA-9607240 1.003299e-01 0.999 1 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.052348e-01 0.978 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.608598e-02 1.065 1 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.052348e-01 0.978 0 0
Reelin signalling pathway R-HSA-8866376 7.487693e-02 1.126 0 0
Signaling by MST1 R-HSA-8852405 8.510834e-02 1.070 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 1.151323e-01 0.939 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.141820e-02 1.212 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.689496e-02 1.114 0 0
MET Receptor Activation R-HSA-6806942 9.522722e-02 1.021 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 6.453175e-02 1.190 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 8.510834e-02 1.070 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 1.031559e-01 0.987 0 0
RET signaling R-HSA-8853659 8.339557e-02 1.079 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.453175e-02 1.190 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 8.510834e-02 1.070 0 0
VLDL clearance R-HSA-8964046 1.052348e-01 0.978 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.353275e-02 1.134 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.038239e-01 0.984 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.003299e-01 0.999 0 0
Netrin-1 signaling R-HSA-373752 1.144990e-01 0.941 0 0
Netrin mediated repulsion signals R-HSA-418886 1.052348e-01 0.978 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 8.510834e-02 1.070 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 8.510834e-02 1.070 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.151323e-01 0.939 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.220143e-02 1.206 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.846681e-02 1.233 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.141820e-02 1.212 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.012448e-02 1.096 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.012448e-02 1.096 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.886618e-02 1.230 0 0
Signaling by ERBB4 R-HSA-1236394 6.430023e-02 1.192 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.288622e-02 1.201 1 0
Innate Immune System R-HSA-168249 7.417011e-02 1.130 0 0
Signaling by FGFR2 R-HSA-5654738 7.583131e-02 1.120 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.151323e-01 0.939 0 0
Signaling by Interleukins R-HSA-449147 1.074301e-01 0.969 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 6.218740e-02 1.206 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 1.038239e-01 0.984 0 0
Cyclin D associated events in G1 R-HSA-69231 1.144990e-01 0.941 0 0
G1 Phase R-HSA-69236 1.144990e-01 0.941 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.746922e-02 1.171 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.013655e-01 0.994 0 0
SARS-CoV Infections R-HSA-9679506 1.105091e-01 0.957 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 1.176398e-01 0.929 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.187901e-01 0.925 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.197168e-01 0.922 0 0
Apoptotic execution phase R-HSA-75153 1.217655e-01 0.914 0 0
Signaling by FGFR R-HSA-190236 1.224592e-01 0.912 0 0
FOXO-mediated transcription R-HSA-9614085 1.248958e-01 0.903 0 0
ARMS-mediated activation R-HSA-170984 1.249209e-01 0.903 0 0
Gap junction degradation R-HSA-190873 1.249209e-01 0.903 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 1.249209e-01 0.903 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.249209e-01 0.903 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.263368e-01 0.898 0 0
Gap junction trafficking and regulation R-HSA-157858 1.328683e-01 0.877 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.346019e-01 0.871 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.346019e-01 0.871 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.346019e-01 0.871 0 0
Regulation of CDH11 function R-HSA-9762292 1.346019e-01 0.871 0 0
PI3K/AKT activation R-HSA-198203 1.346019e-01 0.871 0 0
Signal attenuation R-HSA-74749 1.346019e-01 0.871 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.346019e-01 0.871 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.441698e-01 0.841 0 0
Conjugation of benzoate with glycine R-HSA-177135 1.441763e-01 0.841 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 1.441763e-01 0.841 0 0
Dissolution of Fibrin Clot R-HSA-75205 1.441763e-01 0.841 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.458724e-01 0.836 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.475814e-01 0.831 0 0
Signaling by ALK in cancer R-HSA-9700206 1.475814e-01 0.831 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.501809e-01 0.823 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.501809e-01 0.823 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.536454e-01 0.813 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.598004e-01 0.796 0 0
G alpha (s) signalling events R-HSA-418555 1.626300e-01 0.789 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.630103e-01 0.788 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.630103e-01 0.788 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.630103e-01 0.788 0 0
Conjugation of salicylate with glycine R-HSA-177128 1.630103e-01 0.788 0 0
Interleukin-15 signaling R-HSA-8983432 1.630103e-01 0.788 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.630103e-01 0.788 0 0
Disorders of Nervous System Development R-HSA-9697154 1.630103e-01 0.788 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.630103e-01 0.788 0 0
Pervasive developmental disorders R-HSA-9005895 1.630103e-01 0.788 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.634777e-01 0.787 0 0
Neutrophil degranulation R-HSA-6798695 1.650946e-01 0.782 0 0
Leishmania parasite growth and survival R-HSA-9664433 1.668786e-01 0.778 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 1.668786e-01 0.778 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.711668e-01 0.767 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.722721e-01 0.764 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.722721e-01 0.764 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 1.722721e-01 0.764 0 0
Frs2-mediated activation R-HSA-170968 1.722721e-01 0.764 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.722721e-01 0.764 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.722721e-01 0.764 0 0
Kinesins R-HSA-983189 1.752609e-01 0.756 0 0
GPCR downstream signalling R-HSA-388396 1.763118e-01 0.754 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.769403e-01 0.752 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.769403e-01 0.752 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.814320e-01 0.741 0 0
Hemostasis R-HSA-109582 1.868983e-01 0.728 1 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.904912e-01 0.720 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.904912e-01 0.720 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.904912e-01 0.720 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.904912e-01 0.720 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.904912e-01 0.720 0 0
p38MAPK events R-HSA-171007 1.904912e-01 0.720 0 0
Protein methylation R-HSA-8876725 1.904912e-01 0.720 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.904912e-01 0.720 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.904912e-01 0.720 0 0
Insulin receptor signalling cascade R-HSA-74751 1.911711e-01 0.719 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.951791e-01 0.710 0 0
Negative regulation of FLT3 R-HSA-9706369 1.994506e-01 0.700 1 1
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.994506e-01 0.700 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 1.994506e-01 0.700 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 1.994506e-01 0.700 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.994506e-01 0.700 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.994506e-01 0.700 0 0
Differentiation of T cells R-HSA-9945266 1.994506e-01 0.700 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 1.994506e-01 0.700 0 0
Kidney development R-HSA-9830369 2.032263e-01 0.692 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.083114e-01 0.681 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.083114e-01 0.681 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.083114e-01 0.681 0 0
Disorders of Developmental Biology R-HSA-9675151 2.083114e-01 0.681 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.113104e-01 0.675 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.136736e-01 0.670 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.170746e-01 0.663 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.170746e-01 0.663 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 2.170746e-01 0.663 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.170746e-01 0.663 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.170746e-01 0.663 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.170746e-01 0.663 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.257414e-01 0.646 0 0
Ephrin signaling R-HSA-3928664 2.257414e-01 0.646 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.257414e-01 0.646 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.257414e-01 0.646 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.257414e-01 0.646 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.257414e-01 0.646 0 0
Apoptotic factor-mediated response R-HSA-111471 2.257414e-01 0.646 0 0
Tie2 Signaling R-HSA-210993 2.257414e-01 0.646 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.275679e-01 0.643 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.276727e-01 0.643 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.279439e-01 0.642 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.343128e-01 0.630 0 0
Conjugation of carboxylic acids R-HSA-159424 2.343128e-01 0.630 0 0
Amino Acid conjugation R-HSA-156587 2.343128e-01 0.630 0 0
Rap1 signalling R-HSA-392517 2.343128e-01 0.630 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.357310e-01 0.628 0 0
mRNA Splicing R-HSA-72172 2.395133e-01 0.621 0 0
Interleukin-12 signaling R-HSA-9020591 2.398189e-01 0.620 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.405612e-01 0.619 0 0
Negative regulation of MET activity R-HSA-6807004 2.427899e-01 0.615 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.427899e-01 0.615 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.511736e-01 0.600 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.511736e-01 0.600 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.511736e-01 0.600 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.514540e-01 0.600 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.594649e-01 0.586 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.594649e-01 0.586 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.644005e-01 0.578 0 0
Notch-HLH transcription pathway R-HSA-350054 2.676650e-01 0.572 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.676650e-01 0.572 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.676650e-01 0.572 0 0
LDL clearance R-HSA-8964038 2.676650e-01 0.572 0 0
Signaling by GPCR R-HSA-372790 2.723295e-01 0.565 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.753030e-01 0.560 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.757748e-01 0.559 0 0
Termination of O-glycan biosynthesis R-HSA-977068 2.757748e-01 0.559 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.757748e-01 0.559 0 0
Growth hormone receptor signaling R-HSA-982772 2.757748e-01 0.559 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.767017e-01 0.558 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.837953e-01 0.547 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.837953e-01 0.547 0 0
Interleukin-6 family signaling R-HSA-6783589 2.837953e-01 0.547 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 2.837953e-01 0.547 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.848971e-01 0.545 0 0
Potential therapeutics for SARS R-HSA-9679191 2.873177e-01 0.542 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.889918e-01 0.539 0 0
Interleukin-12 family signaling R-HSA-447115 2.889918e-01 0.539 0 0
Long-term potentiation R-HSA-9620244 2.917274e-01 0.535 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.917274e-01 0.535 0 0
Peptide chain elongation R-HSA-156902 2.930839e-01 0.533 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 2.933414e-01 0.533 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.995722e-01 0.523 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.995722e-01 0.523 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 3.073306e-01 0.512 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 3.073306e-01 0.512 1 1
Triglyceride biosynthesis R-HSA-75109 3.073306e-01 0.512 0 0
Synthesis of PE R-HSA-1483213 3.073306e-01 0.512 0 0
IRE1alpha activates chaperones R-HSA-381070 3.094172e-01 0.509 0 0
Protein folding R-HSA-391251 3.134897e-01 0.504 0 0
Signaling by Insulin receptor R-HSA-74752 3.134897e-01 0.504 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 3.150035e-01 0.502 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.150035e-01 0.502 0 0
Pyroptosis R-HSA-5620971 3.150035e-01 0.502 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.225919e-01 0.491 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.225919e-01 0.491 0 0
Apoptosis R-HSA-109581 3.235574e-01 0.490 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.300967e-01 0.481 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.300967e-01 0.481 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.300967e-01 0.481 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 3.300967e-01 0.481 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.337681e-01 0.477 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.337681e-01 0.477 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.375188e-01 0.472 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.375188e-01 0.472 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.375188e-01 0.472 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.448591e-01 0.462 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.448591e-01 0.462 0 0
G0 and Early G1 R-HSA-1538133 3.448591e-01 0.462 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.521185e-01 0.453 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.521185e-01 0.453 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.521185e-01 0.453 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.521185e-01 0.453 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.521185e-01 0.453 0 0
G-protein beta:gamma signalling R-HSA-397795 3.521185e-01 0.453 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.521185e-01 0.453 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.521185e-01 0.453 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.521185e-01 0.453 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.592980e-01 0.445 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.592980e-01 0.445 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.592980e-01 0.445 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 3.663983e-01 0.436 0 0
Gap junction assembly R-HSA-190861 3.663983e-01 0.436 0 0
Nuclear import of Rev protein R-HSA-180746 3.663983e-01 0.436 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.663983e-01 0.436 0 0
Signal amplification R-HSA-392518 3.663983e-01 0.436 0 0
Mitophagy R-HSA-5205647 3.663983e-01 0.436 0 0
RSV-host interactions R-HSA-9833110 3.698053e-01 0.432 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.734204e-01 0.428 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.734204e-01 0.428 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.734204e-01 0.428 0 0
PERK regulates gene expression R-HSA-381042 3.734204e-01 0.428 0 0
FLT3 signaling in disease R-HSA-9682385 3.803651e-01 0.420 0 0
HSF1 activation R-HSA-3371511 3.803651e-01 0.420 0 0
Translation R-HSA-72766 3.844144e-01 0.415 0 0
Voltage gated Potassium channels R-HSA-1296072 3.872332e-01 0.412 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.872332e-01 0.412 0 0
SLC-mediated transport of organic cations R-HSA-549127 3.872332e-01 0.412 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.912625e-01 0.408 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.940256e-01 0.404 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.007432e-01 0.397 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.007432e-01 0.397 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.007432e-01 0.397 0 0
Plasma lipoprotein clearance R-HSA-8964043 4.007432e-01 0.397 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.011868e-01 0.397 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.011868e-01 0.397 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.073867e-01 0.390 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.073867e-01 0.390 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.073867e-01 0.390 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.073867e-01 0.390 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 4.073867e-01 0.390 0 0
Diseases of Immune System R-HSA-5260271 4.073867e-01 0.390 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.073867e-01 0.390 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.073867e-01 0.390 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.073867e-01 0.390 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.089201e-01 0.388 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.139569e-01 0.383 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.139569e-01 0.383 0 0
HIV Transcription Initiation R-HSA-167161 4.204547e-01 0.376 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.204547e-01 0.376 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.204547e-01 0.376 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.204547e-01 0.376 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.268809e-01 0.370 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.332362e-01 0.363 0 0
Gap junction trafficking R-HSA-190828 4.395214e-01 0.357 0 0
Cellular response to heat stress R-HSA-3371556 4.430978e-01 0.354 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.457373e-01 0.351 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.457373e-01 0.351 0 0
Signaling by ROBO receptors R-HSA-376176 4.487223e-01 0.348 0 0
MHC class II antigen presentation R-HSA-2132295 4.505460e-01 0.346 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.518847e-01 0.345 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.518847e-01 0.345 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.518847e-01 0.345 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.518847e-01 0.345 0 0
Formation of the cornified envelope R-HSA-6809371 4.542491e-01 0.343 0 0
Programmed Cell Death R-HSA-5357801 4.573690e-01 0.340 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.579642e-01 0.339 0 0
Recycling pathway of L1 R-HSA-437239 4.579642e-01 0.339 0 0
Synthesis of PC R-HSA-1483191 4.579642e-01 0.339 0 0
Interferon Signaling R-HSA-913531 4.673395e-01 0.330 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.699228e-01 0.328 0 0
PI3K Cascade R-HSA-109704 4.758034e-01 0.323 0 0
Azathioprine ADME R-HSA-9748787 4.758034e-01 0.323 0 0
mRNA 3'-end processing R-HSA-72187 4.873706e-01 0.312 0 0
Neurexins and neuroligins R-HSA-6794361 4.873706e-01 0.312 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.873706e-01 0.312 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.930587e-01 0.307 0 0
Smooth Muscle Contraction R-HSA-445355 4.930587e-01 0.307 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.986839e-01 0.302 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.986839e-01 0.302 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.042472e-01 0.297 0 0
Signaling by NOTCH3 R-HSA-9012852 5.042472e-01 0.297 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.097490e-01 0.293 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 5.097490e-01 0.293 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.114842e-01 0.291 0 0
IRS-mediated signalling R-HSA-112399 5.151901e-01 0.288 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.151901e-01 0.288 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.205711e-01 0.284 0 0
Metabolism of non-coding RNA R-HSA-194441 5.258928e-01 0.279 0 0
snRNP Assembly R-HSA-191859 5.258928e-01 0.279 0 0
Peroxisomal protein import R-HSA-9033241 5.258928e-01 0.279 0 0
Triglyceride metabolism R-HSA-8979227 5.258928e-01 0.279 0 0
RAB geranylgeranylation R-HSA-8873719 5.311557e-01 0.275 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.311557e-01 0.275 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.311557e-01 0.275 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.311557e-01 0.275 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.311557e-01 0.275 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.311557e-01 0.275 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.311557e-01 0.275 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.319184e-01 0.274 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.319184e-01 0.274 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.363605e-01 0.271 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.363605e-01 0.271 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.363605e-01 0.271 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.415078e-01 0.266 0 0
Heme signaling R-HSA-9707616 5.415078e-01 0.266 0 0
tRNA processing in the nucleus R-HSA-6784531 5.415078e-01 0.266 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.415078e-01 0.266 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.415078e-01 0.266 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.465983e-01 0.262 0 0
Extracellular matrix organization R-HSA-1474244 5.490817e-01 0.260 0 0
CD22 mediated BCR regulation R-HSA-5690714 5.516326e-01 0.258 0 0
Gastrulation R-HSA-9758941 5.550168e-01 0.256 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.646680e-01 0.248 0 0
O-linked glycosylation of mucins R-HSA-913709 5.712200e-01 0.243 0 0
Transcription of the HIV genome R-HSA-167172 5.712200e-01 0.243 0 0
Regulated Necrosis R-HSA-5218859 5.712200e-01 0.243 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.741691e-01 0.241 0 0
PPARA activates gene expression R-HSA-1989781 5.741691e-01 0.241 0 0
Autophagy R-HSA-9612973 5.773026e-01 0.239 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 5.804194e-01 0.236 0 0
HIV Life Cycle R-HSA-162587 5.804194e-01 0.236 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.853500e-01 0.233 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.853500e-01 0.233 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 5.853500e-01 0.233 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.853500e-01 0.233 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.899563e-01 0.229 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.945118e-01 0.226 0 0
Aspirin ADME R-HSA-9749641 5.945118e-01 0.226 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.990169e-01 0.223 0 0
Signaling by FGFR in disease R-HSA-1226099 5.990169e-01 0.223 0 0
Signaling by NOTCH4 R-HSA-9013694 5.990169e-01 0.223 0 0
Signaling by NOTCH1 R-HSA-1980143 6.078783e-01 0.216 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.122357e-01 0.213 0 0
Metabolism of RNA R-HSA-8953854 6.151599e-01 0.211 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.165449e-01 0.210 0 0
Integrin cell surface interactions R-HSA-216083 6.165449e-01 0.210 0 0
Membrane Trafficking R-HSA-199991 6.173500e-01 0.209 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.208065e-01 0.207 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.250211e-01 0.204 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.291890e-01 0.201 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.364469e-01 0.196 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.373872e-01 0.196 0 0
Influenza Infection R-HSA-168255 6.474725e-01 0.189 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.493477e-01 0.188 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.532467e-01 0.185 0 0
Post NMDA receptor activation events R-HSA-438064 6.571026e-01 0.182 0 0
Selective autophagy R-HSA-9663891 6.609158e-01 0.180 0 0
ER-Phagosome pathway R-HSA-1236974 6.646869e-01 0.177 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.721044e-01 0.173 0 0
Bacterial Infection Pathways R-HSA-9824439 6.724982e-01 0.172 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.757517e-01 0.170 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.793587e-01 0.168 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.814880e-01 0.167 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.899419e-01 0.161 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.933919e-01 0.159 0 0
Eukaryotic Translation Termination R-HSA-72764 6.933919e-01 0.159 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.968037e-01 0.157 0 0
Potassium Channels R-HSA-1296071 6.968037e-01 0.157 0 0
Vesicle-mediated transport R-HSA-5653656 7.072240e-01 0.150 0 0
Glycolysis R-HSA-70171 7.100775e-01 0.149 0 0
Selenocysteine synthesis R-HSA-2408557 7.133047e-01 0.147 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.164961e-01 0.145 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.164961e-01 0.145 0 0
PI Metabolism R-HSA-1483255 7.164961e-01 0.145 0 0
Keratinization R-HSA-6805567 7.173723e-01 0.144 0 0
Viral mRNA Translation R-HSA-192823 7.196522e-01 0.143 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.227733e-01 0.141 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.227733e-01 0.141 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.349161e-01 0.134 0 0
Synthesis of DNA R-HSA-69239 7.349161e-01 0.134 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.378682e-01 0.132 0 0
Stimuli-sensing channels R-HSA-2672351 7.378682e-01 0.132 0 0
Drug ADME R-HSA-9748784 7.435938e-01 0.129 0 0
TCR signaling R-HSA-202403 7.436748e-01 0.129 1 0
Antimicrobial peptides R-HSA-6803157 7.465299e-01 0.127 0 0
Inositol phosphate metabolism R-HSA-1483249 7.493534e-01 0.125 0 0
HIV Infection R-HSA-162906 7.618767e-01 0.118 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.630085e-01 0.117 0 0
Metabolism of proteins R-HSA-392499 7.648230e-01 0.116 0 0
L1CAM interactions R-HSA-373760 7.656494e-01 0.116 0 0
Glucose metabolism R-HSA-70326 7.682610e-01 0.114 0 0
Rab regulation of trafficking R-HSA-9007101 7.682610e-01 0.114 0 0
Mitochondrial biogenesis R-HSA-1592230 7.682610e-01 0.114 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.733978e-01 0.112 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.733978e-01 0.112 0 0
Post-translational protein modification R-HSA-597592 7.774156e-01 0.109 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.808915e-01 0.107 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.808915e-01 0.107 0 0
Host Interactions of HIV factors R-HSA-162909 7.857498e-01 0.105 0 0
Neuronal System R-HSA-112316 7.952744e-01 0.099 0 0
Adipogenesis R-HSA-9843745 8.063199e-01 0.093 0 0
Circadian clock R-HSA-9909396 8.084806e-01 0.092 0 0
Degradation of the extracellular matrix R-HSA-1474228 8.084806e-01 0.092 0 0
O-linked glycosylation R-HSA-5173105 8.209505e-01 0.086 0 0
Ribosome-associated quality control R-HSA-9948299 8.229489e-01 0.085 0 0
PTEN Regulation R-HSA-6807070 8.249250e-01 0.084 0 0
Macroautophagy R-HSA-1632852 8.288118e-01 0.082 0 0
Cellular response to chemical stress R-HSA-9711123 8.315588e-01 0.080 0 0
Clathrin-mediated endocytosis R-HSA-8856828 8.344817e-01 0.079 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.363298e-01 0.078 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.435194e-01 0.074 0 0
S Phase R-HSA-69242 8.435194e-01 0.074 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 8.469955e-01 0.072 0 0
Protein localization R-HSA-9609507 8.520662e-01 0.070 0 0
Cellular response to starvation R-HSA-9711097 8.601487e-01 0.065 0 0
Interferon gamma signaling R-HSA-877300 8.617117e-01 0.065 0 0
Phospholipid metabolism R-HSA-1483257 8.668670e-01 0.062 0 0
Selenoamino acid metabolism R-HSA-2408522 8.692700e-01 0.061 0 0
SLC transporter disorders R-HSA-5619102 8.736062e-01 0.059 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.791662e-01 0.056 0 0
tRNA processing R-HSA-72306 8.791662e-01 0.056 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.933986e-01 0.049 0 0
Diseases of glycosylation R-HSA-3781865 8.967787e-01 0.047 0 0
G2/M Transition R-HSA-69275 8.990770e-01 0.046 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.013244e-01 0.045 0 0
Mitotic G2-G2/M phases R-HSA-453274 9.013244e-01 0.045 0 0
Ion channel transport R-HSA-983712 9.024293e-01 0.045 0 0
Cilium Assembly R-HSA-5617833 9.035220e-01 0.044 0 0
Toll-like Receptor Cascades R-HSA-168898 9.046025e-01 0.044 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.166667e-01 0.038 0 0
Muscle contraction R-HSA-397014 9.255521e-01 0.034 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.255521e-01 0.034 0 0
Mitotic Anaphase R-HSA-68882 9.288365e-01 0.032 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 9.296349e-01 0.032 0 0
rRNA processing R-HSA-72312 9.405944e-01 0.027 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.406453e-01 0.027 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.451105e-01 0.025 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.498550e-01 0.022 0 0
G alpha (q) signalling events R-HSA-416476 9.586258e-01 0.018 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.662540e-01 0.015 0 0
Transmission across Chemical Synapses R-HSA-112315 9.788044e-01 0.009 0 0
Metabolism of steroids R-HSA-8957322 9.790438e-01 0.009 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.909757e-01 0.004 0 0
G alpha (i) signalling events R-HSA-418594 9.919493e-01 0.004 0 0
Diseases of metabolism R-HSA-5668914 9.935940e-01 0.003 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.953504e-01 0.002 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.958537e-01 0.002 0 0
Biological oxidations R-HSA-211859 9.978699e-01 0.001 0 0
Transport of small molecules R-HSA-382551 9.991588e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.992883e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999724e-01 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell-Cell communication R-HSA-1500931 2.673950e-11 10.573 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.716272e-11 10.566 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.716272e-11 10.566 0 0
EPH-Ephrin signaling R-HSA-2682334 4.506495e-11 10.346 0 0
Regulation of CDH1 Function R-HSA-9764561 7.741652e-11 10.111 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.697636e-10 9.770 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.663019e-10 9.247 0 0
Cell junction organization R-HSA-446728 1.309894e-09 8.883 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.213436e-09 8.916 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.671535e-09 8.246 0 0
PECAM1 interactions R-HSA-210990 7.860493e-09 8.105 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 9.789870e-09 8.009 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 9.789870e-09 8.009 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.119016e-08 7.951 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.404336e-08 7.853 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 3.930742e-08 7.406 0 0
Activation of BH3-only proteins R-HSA-114452 9.247259e-08 7.034 0 0
Cell-cell junction organization R-HSA-421270 1.022800e-07 6.990 0 0
Adherens junctions interactions R-HSA-418990 1.343290e-07 6.872 0 0
Ephrin signaling R-HSA-3928664 1.436435e-07 6.843 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.531338e-07 6.452 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.530900e-07 6.452 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.850094e-07 6.105 0 0
Axon guidance R-HSA-422475 9.464524e-07 6.024 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.155453e-06 5.937 0 0
Regulation of KIT signaling R-HSA-1433559 1.201867e-06 5.920 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.365144e-06 5.865 0 0
Infectious disease R-HSA-5663205 1.387160e-06 5.858 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.618200e-06 5.791 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.613510e-06 5.792 1 0
Cell-extracellular matrix interactions R-HSA-446353 1.562472e-06 5.806 0 0
Signaling by VEGF R-HSA-194138 1.622492e-06 5.790 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.222241e-06 5.653 0 0
Nef and signal transduction R-HSA-164944 2.334256e-06 5.632 0 0
Nervous system development R-HSA-9675108 2.461882e-06 5.609 0 0
Smooth Muscle Contraction R-HSA-445355 3.019147e-06 5.520 0 0
Muscle contraction R-HSA-397014 4.030596e-06 5.395 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.122209e-06 5.385 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.168947e-06 5.380 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.875698e-06 5.231 0 0
Semaphorin interactions R-HSA-373755 8.048435e-06 5.094 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.011150e-05 4.995 0 0
Signaling by KIT in disease R-HSA-9669938 1.011150e-05 4.995 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.087770e-05 4.963 1 1
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.591397e-05 4.798 0 0
Glycolysis R-HSA-70171 1.716643e-05 4.765 0 0
Programmed Cell Death R-HSA-5357801 1.722185e-05 4.764 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.871333e-05 4.728 1 1
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.871333e-05 4.728 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.871333e-05 4.728 1 1
Signaling by RAS mutants R-HSA-6802949 1.871333e-05 4.728 1 0
G2/M DNA damage checkpoint R-HSA-69473 2.015574e-05 4.696 0 0
Gluconeogenesis R-HSA-70263 2.290293e-05 4.640 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.693890e-05 4.570 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.255577e-05 4.487 0 0
Non-canonical inflammasome activation R-HSA-9686114 3.485630e-05 4.458 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.294162e-05 4.367 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.663043e-05 4.331 0 0
Striated Muscle Contraction R-HSA-390522 5.470775e-05 4.262 0 0
Glucose metabolism R-HSA-70326 5.475002e-05 4.262 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.140910e-05 4.212 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.187335e-05 4.208 1 0
HSF1 activation R-HSA-3371511 7.669850e-05 4.115 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.536395e-05 4.069 1 1
Signaling by Interleukins R-HSA-449147 7.835884e-05 4.106 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.619341e-05 4.065 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 9.796233e-05 4.009 1 1
Regulation of signaling by CBL R-HSA-912631 1.052172e-04 3.978 0 0
Attenuation phase R-HSA-3371568 1.159322e-04 3.936 0 0
FOXO-mediated transcription R-HSA-9614085 1.252722e-04 3.902 0 0
MAP2K and MAPK activation R-HSA-5674135 1.405512e-04 3.852 1 1
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.542676e-04 3.812 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.603780e-04 3.795 0 0
Signaling by SCF-KIT R-HSA-1433557 1.689845e-04 3.772 0 0
Parasite infection R-HSA-9664407 1.879844e-04 3.726 0 0
Leishmania phagocytosis R-HSA-9664417 1.879844e-04 3.726 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 1.879844e-04 3.726 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.890573e-04 3.723 0 0
Interleukin-18 signaling R-HSA-9012546 1.934790e-04 3.713 0 0
Extracellular matrix organization R-HSA-1474244 2.128724e-04 3.672 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.158915e-04 3.666 0 0
Parasitic Infection Pathways R-HSA-9824443 2.234660e-04 3.651 0 0
Leishmania infection R-HSA-9658195 2.234660e-04 3.651 0 0
Degradation of CDH1 R-HSA-9766229 2.810685e-04 3.551 0 0
Co-stimulation by CD28 R-HSA-389356 2.593001e-04 3.586 0 0
CASP4 inflammasome assembly R-HSA-9948001 3.147808e-04 3.502 0 0
HSF1-dependent transactivation R-HSA-3371571 3.287387e-04 3.483 0 0
Cell Cycle R-HSA-1640170 3.423736e-04 3.465 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.564805e-04 3.448 1 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.903243e-04 3.409 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.275573e-04 3.369 0 0
Cellular response to heat stress R-HSA-3371556 4.283122e-04 3.368 0 0
Cell Cycle Checkpoints R-HSA-69620 4.873780e-04 3.312 0 0
Apoptosis R-HSA-109581 4.642350e-04 3.333 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 5.529808e-04 3.257 0 0
Platelet degranulation R-HSA-114608 5.763081e-04 3.239 0 0
G2/M Checkpoints R-HSA-69481 5.763081e-04 3.239 0 0
FCGR activation R-HSA-2029481 6.070801e-04 3.217 0 0
SARS-CoV Infections R-HSA-9679506 6.360507e-04 3.197 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 6.838906e-04 3.165 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 6.838906e-04 3.165 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.548461e-04 3.122 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.548461e-04 3.122 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.623809e-04 3.118 0 0
AURKA Activation by TPX2 R-HSA-8854518 9.067450e-04 3.043 0 0
GPVI-mediated activation cascade R-HSA-114604 9.379298e-04 3.028 0 0
Signal Transduction R-HSA-162582 8.099772e-04 3.092 1 0
Bacterial Infection Pathways R-HSA-9824439 8.541889e-04 3.068 0 0
Viral Infection Pathways R-HSA-9824446 9.606325e-04 3.017 0 0
Membrane Trafficking R-HSA-199991 1.030693e-03 2.987 0 0
Hemostasis R-HSA-109582 1.073171e-03 2.969 1 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.154515e-03 2.938 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.324572e-03 2.878 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.348601e-03 2.870 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.402025e-03 2.853 0 0
Vesicle-mediated transport R-HSA-5653656 1.486508e-03 2.828 0 0
Centrosome maturation R-HSA-380287 1.499808e-03 2.824 0 0
Interleukin-12 signaling R-HSA-9020591 1.579924e-03 2.801 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.625831e-03 2.789 0 0
L1CAM interactions R-HSA-373760 1.976414e-03 2.704 0 0
Disease R-HSA-1643685 2.306207e-03 2.637 1 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.549678e-03 2.594 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.338635e-03 2.631 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.708073e-03 2.567 1 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.367144e-03 2.626 0 0
Interleukin-12 family signaling R-HSA-447115 2.804072e-03 2.552 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.930191e-03 2.533 0 0
Developmental Biology R-HSA-1266738 3.050243e-03 2.516 0 0
Syndecan interactions R-HSA-3000170 3.114269e-03 2.507 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.125248e-03 2.505 0 0
Leishmania parasite growth and survival R-HSA-9664433 3.171599e-03 2.499 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 3.171599e-03 2.499 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.194656e-03 2.496 0 0
Cell surface interactions at the vascular wall R-HSA-202733 4.260756e-03 2.371 0 0
G2/M Transition R-HSA-69275 4.515903e-03 2.345 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.540367e-03 2.343 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.755933e-03 2.323 0 0
Immune System R-HSA-168256 4.812919e-03 2.318 1 0
Signaling by ERBB2 R-HSA-1227986 4.853513e-03 2.314 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.094562e-03 2.293 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 5.458538e-03 2.263 0 0
Formation of annular gap junctions R-HSA-196025 5.458538e-03 2.263 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.548838e-03 2.256 0 0
DAP12 signaling R-HSA-2424491 5.666357e-03 2.247 0 0
Gap junction degradation R-HSA-190873 6.454398e-03 2.190 0 0
Integrin signaling R-HSA-354192 7.051544e-03 2.152 1 1
GP1b-IX-V activation signalling R-HSA-430116 6.454398e-03 2.190 0 0
Ion transport by P-type ATPases R-HSA-936837 5.918969e-03 2.228 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.454398e-03 2.190 0 0
Innate Immune System R-HSA-168249 7.234782e-03 2.141 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.885090e-03 2.230 1 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.207748e-03 2.207 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.526350e-03 2.123 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.526350e-03 2.123 0 0
RAF activation R-HSA-5673000 8.076911e-03 2.093 0 0
eNOS activation R-HSA-203615 8.076911e-03 2.093 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 1.037901e-02 1.984 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.118315e-02 1.951 0 0
Cellular responses to stimuli R-HSA-8953897 1.133162e-02 1.946 0 0
Generation of second messenger molecules R-HSA-202433 1.165825e-02 1.933 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.206285e-02 1.919 0 0
FLT3 Signaling R-HSA-9607240 1.233037e-02 1.909 1 0
CD28 dependent Vav1 pathway R-HSA-389359 1.254398e-02 1.902 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.397327e-02 1.855 0 0
Signal regulatory protein family interactions R-HSA-391160 1.397327e-02 1.855 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.447808e-02 1.839 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.505927e-02 1.822 0 0
DAP12 interactions R-HSA-2172127 1.523805e-02 1.817 0 0
DCC mediated attractive signaling R-HSA-418885 1.546957e-02 1.811 0 0
Protein methylation R-HSA-8876725 1.546957e-02 1.811 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.602018e-02 1.795 1 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.703142e-02 1.769 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.703142e-02 1.769 0 0
Recycling pathway of L1 R-HSA-437239 1.765117e-02 1.753 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.034618e-02 1.692 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.034618e-02 1.692 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.209632e-02 1.656 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.865742e-02 1.729 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.390648e-02 1.621 0 0
Gap junction trafficking and regulation R-HSA-157858 1.937142e-02 1.713 0 0
Rap1 signalling R-HSA-392517 2.390648e-02 1.621 0 0
Adaptive Immune System R-HSA-1280218 1.866138e-02 1.729 1 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.044929e-02 1.689 1 0
Uptake and function of anthrax toxins R-HSA-5210891 2.034618e-02 1.692 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.034108e-02 1.692 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.209632e-02 1.656 0 0
Signaling by Hippo R-HSA-2028269 2.034618e-02 1.692 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.898722e-02 1.722 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.568585e-02 1.590 0 0
Nephrin family interactions R-HSA-373753 2.577533e-02 1.589 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.577533e-02 1.589 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.577533e-02 1.589 0 0
Signal transduction by L1 R-HSA-445144 2.577533e-02 1.589 0 0
Formation of definitive endoderm R-HSA-9823730 2.577533e-02 1.589 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 2.609794e-02 1.583 0 0
Basigin interactions R-HSA-210991 2.770157e-02 1.557 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.770157e-02 1.557 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.792081e-02 1.554 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.968389e-02 1.527 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.968389e-02 1.527 0 0
MAPK family signaling cascades R-HSA-5683057 3.013273e-02 1.521 1 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.043394e-02 1.517 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.273539e-02 1.485 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.464167e-02 1.460 1 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 3.595476e-02 1.444 0 0
Neurodegenerative Diseases R-HSA-8863678 3.595476e-02 1.444 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.595476e-02 1.444 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.595476e-02 1.444 0 0
HIV Infection R-HSA-162906 3.682327e-02 1.434 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.708478e-02 1.431 0 0
Long-term potentiation R-HSA-9620244 3.814889e-02 1.419 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.814889e-02 1.419 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.814889e-02 1.419 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.873067e-02 1.412 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.873067e-02 1.412 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.873067e-02 1.412 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.873067e-02 1.412 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.873067e-02 1.412 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.873067e-02 1.412 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.873067e-02 1.412 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.873067e-02 1.412 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.873067e-02 1.412 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.873067e-02 1.412 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.873067e-02 1.412 0 0
Axonal growth stimulation R-HSA-209563 4.817811e-02 1.317 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.016778e-02 1.396 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.281916e-02 1.368 0 0
Integrin cell surface interactions R-HSA-216083 5.427286e-02 1.265 0 0
MET activates PTK2 signaling R-HSA-8874081 4.039294e-02 1.394 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 4.268572e-02 1.370 1 1
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.741285e-02 1.324 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.873067e-02 1.412 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 4.817811e-02 1.317 0 0
MET interacts with TNS proteins R-HSA-8875513 4.817811e-02 1.317 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.268572e-02 1.370 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.832727e-02 1.416 1 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.817811e-02 1.317 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.984494e-02 1.302 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.817811e-02 1.317 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.268572e-02 1.370 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.232122e-02 1.281 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.484060e-02 1.261 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.268572e-02 1.370 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.268572e-02 1.370 0 0
Cilium Assembly R-HSA-5617833 5.736436e-02 1.241 0 0
Signaling by NOTCH4 R-HSA-9013694 4.837818e-02 1.315 0 0
Metabolism of RNA R-HSA-8953854 4.483043e-02 1.348 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.268572e-02 1.370 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.740202e-02 1.241 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 4.984494e-02 1.302 0 0
Cellular responses to stress R-HSA-2262752 5.219955e-02 1.282 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.273142e-02 1.369 0 0
Regulated Necrosis R-HSA-5218859 4.016778e-02 1.396 0 0
Host Interactions of HIV factors R-HSA-162909 4.883697e-02 1.311 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.268572e-02 1.370 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.502607e-02 1.347 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 4.761166e-02 1.322 0 0
Regulation of gap junction activity R-HSA-191650 5.753327e-02 1.240 0 0
NADE modulates death signalling R-HSA-205025 5.753327e-02 1.240 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.890930e-02 1.230 0 0
Mitotic Prometaphase R-HSA-68877 6.021373e-02 1.220 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.118121e-02 1.213 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.264672e-02 1.203 0 0
Developmental Cell Lineages R-HSA-9734767 6.291826e-02 1.201 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.532795e-02 1.185 0 0
Signalling to ERKs R-HSA-187687 6.532795e-02 1.185 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.679705e-02 1.175 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.679705e-02 1.175 0 0
Suppression of autophagy R-HSA-9636569 6.679705e-02 1.175 0 0
Reelin signalling pathway R-HSA-8866376 6.679705e-02 1.175 0 0
Cell Cycle, Mitotic R-HSA-69278 6.692803e-02 1.174 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.734065e-02 1.172 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.804707e-02 1.167 0 0
RUNX2 regulates bone development R-HSA-8941326 6.804707e-02 1.167 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.893453e-02 1.162 0 0
mRNA Splicing R-HSA-72172 7.240453e-02 1.140 0 0
MET promotes cell motility R-HSA-8875878 7.359506e-02 1.133 0 0
Elastic fibre formation R-HSA-1566948 7.359506e-02 1.133 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 7.359506e-02 1.133 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.509593e-02 1.124 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.597035e-02 1.119 0 0
Phosphorylation of Emi1 R-HSA-176417 7.597035e-02 1.119 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 7.597035e-02 1.119 0 0
Cam-PDE 1 activation R-HSA-111957 7.597035e-02 1.119 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 7.597035e-02 1.119 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 7.597035e-02 1.119 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 7.597035e-02 1.119 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 7.642199e-02 1.117 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.642199e-02 1.117 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.928294e-02 1.101 0 0
Protein folding R-HSA-391251 8.103376e-02 1.091 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.217697e-02 1.085 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.286618e-02 1.082 0 0
Signaling by NTRKs R-HSA-166520 8.328295e-02 1.079 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.471639e-02 1.072 0 0
Erythropoietin activates STAT5 R-HSA-9027283 8.505404e-02 1.070 0 0
VLDL assembly R-HSA-8866423 8.505404e-02 1.070 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 9.404898e-02 1.027 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 9.404898e-02 1.027 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.029560e-01 0.987 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.029560e-01 0.987 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.205099e-01 0.919 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.205099e-01 0.919 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.205099e-01 0.919 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.462027e-01 0.835 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.629155e-01 0.788 0 0
Erythropoietin activates RAS R-HSA-9027284 1.711496e-01 0.767 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.001858e-01 0.999 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.224129e-01 0.912 0 0
Translation initiation complex formation R-HSA-72649 1.256803e-01 0.901 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.322768e-01 0.879 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.117761e-01 0.952 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 1.362171e-01 0.866 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 9.404898e-02 1.027 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.029560e-01 0.987 0 0
Regulation of CDH11 function R-HSA-9762292 1.205099e-01 0.919 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.525094e-01 0.817 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.205099e-01 0.919 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.462027e-01 0.835 0 0
PTK6 Expression R-HSA-8849473 9.404898e-02 1.027 0 0
Calcineurin activates NFAT R-HSA-2025928 1.117761e-01 0.952 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.629155e-01 0.788 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.711496e-01 0.767 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.184448e-01 0.926 0 0
p75NTR regulates axonogenesis R-HSA-193697 1.117761e-01 0.952 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 1.205099e-01 0.919 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.291585e-01 0.889 0 0
vRNP Assembly R-HSA-192905 1.291585e-01 0.889 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.462027e-01 0.835 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.546002e-01 0.811 0 0
Frs2-mediated activation R-HSA-170968 1.546002e-01 0.811 0 0
TCR signaling R-HSA-202403 1.208559e-01 0.918 1 0
Interleukin-1 processing R-HSA-448706 1.117761e-01 0.952 0 0
Chylomicron assembly R-HSA-8963888 1.291585e-01 0.889 0 0
p38MAPK events R-HSA-171007 1.711496e-01 0.767 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.546002e-01 0.811 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.525094e-01 0.817 0 0
LDL remodeling R-HSA-8964041 9.404898e-02 1.027 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 9.404898e-02 1.027 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.029560e-01 0.987 0 0
ARMS-mediated activation R-HSA-170984 1.117761e-01 0.952 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.205099e-01 0.919 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.377224e-01 0.861 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.546002e-01 0.811 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.711496e-01 0.767 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.001858e-01 0.999 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.389508e-01 0.857 0 0
Ion homeostasis R-HSA-5578775 1.322768e-01 0.879 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.497383e-01 0.825 0 0
Netrin-1 signaling R-HSA-373752 9.406590e-02 1.027 0 0
Netrin mediated repulsion signals R-HSA-418886 9.404898e-02 1.027 0 0
Sodium/Calcium exchangers R-HSA-425561 1.377224e-01 0.861 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.711496e-01 0.767 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.256803e-01 0.901 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 1.001858e-01 0.999 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 1.001858e-01 0.999 0 0
CHL1 interactions R-HSA-447041 9.404898e-02 1.027 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 9.404898e-02 1.027 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.029560e-01 0.987 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.117761e-01 0.952 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 1.117761e-01 0.952 0 0
Pervasive developmental disorders R-HSA-9005895 1.462027e-01 0.835 0 0
Disorders of Nervous System Development R-HSA-9697154 1.462027e-01 0.835 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.462027e-01 0.835 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.629155e-01 0.788 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.711496e-01 0.767 0 0
Gap junction trafficking R-HSA-190828 9.406590e-02 1.027 0 0
GPER1 signaling R-HSA-9634597 1.064135e-01 0.973 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.629155e-01 0.788 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.205099e-01 0.919 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.322768e-01 0.879 0 0
ESR-mediated signaling R-HSA-8939211 1.122883e-01 0.950 0 0
Ion channel transport R-HSA-983712 1.515635e-01 0.819 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.356045e-01 0.868 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.462027e-01 0.835 0 0
Other semaphorin interactions R-HSA-416700 1.711496e-01 0.767 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.201016e-01 0.920 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.029560e-01 0.987 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.711496e-01 0.767 0 0
Interleukin-23 signaling R-HSA-9020933 1.029560e-01 0.987 0 0
Dectin-2 family R-HSA-5621480 1.356045e-01 0.868 0 0
Potential therapeutics for SARS R-HSA-9679191 8.610599e-02 1.065 0 0
Generic Transcription Pathway R-HSA-212436 9.588084e-02 1.018 0 0
G1 Phase R-HSA-69236 9.406590e-02 1.027 0 0
Cyclin D associated events in G1 R-HSA-69231 9.406590e-02 1.027 0 0
Mitochondrial biogenesis R-HSA-1592230 1.407248e-01 0.852 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 1.498880e-01 0.824 0 0
Interleukin-2 signaling R-HSA-9020558 1.291585e-01 0.889 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.104853e-02 1.041 0 0
PIP3 activates AKT signaling R-HSA-1257604 9.341836e-02 1.030 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.191670e-01 0.924 0 0
Signaling by EGFR R-HSA-177929 1.322768e-01 0.879 1 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 9.229171e-02 1.035 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.732967e-01 0.761 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.751524e-01 0.757 0 0
RNA Polymerase II Transcription R-HSA-73857 1.779223e-01 0.750 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 1.779724e-01 0.750 0 0
Phosphorylation of the APC/C R-HSA-176412 1.793031e-01 0.746 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.793031e-01 0.746 0 0
Prolonged ERK activation events R-HSA-169893 1.793031e-01 0.746 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.793031e-01 0.746 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.838574e-01 0.736 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.838574e-01 0.736 0 0
ECM proteoglycans R-HSA-3000178 1.838574e-01 0.736 0 0
Metabolism of cofactors R-HSA-8978934 1.838574e-01 0.736 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.873770e-01 0.727 0 0
Fibronectin matrix formation R-HSA-1566977 1.873770e-01 0.727 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.873770e-01 0.727 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.873770e-01 0.727 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.873770e-01 0.727 0 0
Disorders of Developmental Biology R-HSA-9675151 1.873770e-01 0.727 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.873986e-01 0.727 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.909493e-01 0.719 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.953719e-01 0.709 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.953719e-01 0.709 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 1.953719e-01 0.709 0 0
Neutrophil degranulation R-HSA-6798695 1.954216e-01 0.709 0 0
Protein ubiquitination R-HSA-8852135 1.980775e-01 0.703 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.032887e-01 0.692 0 0
PKA activation R-HSA-163615 2.032887e-01 0.692 0 0
GAB1 signalosome R-HSA-180292 2.032887e-01 0.692 1 1
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.032887e-01 0.692 0 0
Interleukin-10 signaling R-HSA-6783783 2.088288e-01 0.680 0 0
M Phase R-HSA-68886 2.095945e-01 0.679 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.111280e-01 0.675 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.111280e-01 0.675 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.111280e-01 0.675 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.111280e-01 0.675 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 2.111280e-01 0.675 0 0
The NLRP3 inflammasome R-HSA-844456 2.111280e-01 0.675 0 0
Sensory processing of sound R-HSA-9659379 2.124263e-01 0.673 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.134488e-01 0.671 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.160299e-01 0.665 0 0
Signaling by MET R-HSA-6806834 2.160299e-01 0.665 0 0
Signaling by FGFR2 R-HSA-5654738 2.160299e-01 0.665 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.188907e-01 0.660 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.232536e-01 0.651 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.265775e-01 0.645 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.265775e-01 0.645 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.265775e-01 0.645 0 0
Signalling to RAS R-HSA-167044 2.265775e-01 0.645 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.265775e-01 0.645 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.265775e-01 0.645 0 0
Gastrulation R-HSA-9758941 2.288823e-01 0.640 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.314754e-01 0.635 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.341891e-01 0.630 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.341891e-01 0.630 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.341891e-01 0.630 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.341891e-01 0.630 0 0
Ribavirin ADME R-HSA-9755088 2.341891e-01 0.630 0 0
Interleukin-1 family signaling R-HSA-446652 2.366779e-01 0.626 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.377542e-01 0.624 0 0
rRNA processing R-HSA-72312 2.390420e-01 0.622 0 0
DNA Replication R-HSA-69306 2.392870e-01 0.621 0 0
Gene expression (Transcription) R-HSA-74160 2.410183e-01 0.618 0 0
FGFR2 alternative splicing R-HSA-6803529 2.417263e-01 0.617 0 0
mTORC1-mediated signalling R-HSA-166208 2.417263e-01 0.617 0 0
Post NMDA receptor activation events R-HSA-438064 2.450243e-01 0.611 0 0
Pyruvate metabolism R-HSA-70268 2.450243e-01 0.611 0 0
Autophagy R-HSA-9612973 2.471433e-01 0.607 0 0
Diseases of programmed cell death R-HSA-9645723 2.486628e-01 0.604 0 0
Selective autophagy R-HSA-9663891 2.486628e-01 0.604 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.491897e-01 0.603 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.491897e-01 0.603 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.491897e-01 0.603 0 0
Formation of the ureteric bud R-HSA-9830674 2.491897e-01 0.603 0 0
Growth hormone receptor signaling R-HSA-982772 2.491897e-01 0.603 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.491897e-01 0.603 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.524035e-01 0.598 0 0
Downstream TCR signaling R-HSA-202424 2.559451e-01 0.592 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.565802e-01 0.591 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.565802e-01 0.591 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 2.565802e-01 0.591 0 0
Mitochondrial RNA degradation R-HSA-9836573 2.565802e-01 0.591 0 0
Regulation of TP53 Activity R-HSA-5633007 2.576802e-01 0.589 0 0
Signaling by TGFB family members R-HSA-9006936 2.576802e-01 0.589 0 0
Laminin interactions R-HSA-3000157 2.638983e-01 0.579 0 0
Tight junction interactions R-HSA-420029 2.638983e-01 0.579 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.638983e-01 0.579 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.638983e-01 0.579 0 0
Acyl chain remodelling of PS R-HSA-1482801 2.638983e-01 0.579 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.638983e-01 0.579 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 2.638983e-01 0.579 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.705193e-01 0.568 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.711449e-01 0.567 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.711449e-01 0.567 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.711449e-01 0.567 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.778056e-01 0.556 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.783206e-01 0.555 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.783206e-01 0.555 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.783206e-01 0.555 0 0
Insulin processing R-HSA-264876 2.783206e-01 0.555 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.814473e-01 0.551 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 2.850877e-01 0.545 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.850877e-01 0.545 0 0
HIV elongation arrest and recovery R-HSA-167287 2.854260e-01 0.545 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.854260e-01 0.545 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.854260e-01 0.545 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.854260e-01 0.545 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.854260e-01 0.545 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.854260e-01 0.545 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.854260e-01 0.545 0 0
Inflammasomes R-HSA-622312 2.854260e-01 0.545 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.854260e-01 0.545 0 0
Pyroptosis R-HSA-5620971 2.854260e-01 0.545 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.887263e-01 0.540 0 0
Post-translational protein phosphorylation R-HSA-8957275 2.923629e-01 0.534 0 0
Signaling by FGFR R-HSA-190236 2.923629e-01 0.534 0 0
Signaling by Erythropoietin R-HSA-9006335 2.924620e-01 0.534 0 0
mRNA Capping R-HSA-72086 2.924620e-01 0.534 0 0
Thyroxine biosynthesis R-HSA-209968 2.924620e-01 0.534 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.924620e-01 0.534 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.924620e-01 0.534 0 0
DARPP-32 events R-HSA-180024 2.924620e-01 0.534 0 0
Platelet calcium homeostasis R-HSA-418360 2.924620e-01 0.534 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.924620e-01 0.534 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.959972e-01 0.529 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.994291e-01 0.524 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 2.994291e-01 0.524 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.994291e-01 0.524 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.996289e-01 0.523 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.063280e-01 0.514 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 3.063280e-01 0.514 0 0
Budding and maturation of HIV virion R-HSA-162588 3.063280e-01 0.514 0 0
Trafficking of AMPA receptors R-HSA-399719 3.063280e-01 0.514 0 0
Downstream signal transduction R-HSA-186763 3.063280e-01 0.514 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.068831e-01 0.513 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.131594e-01 0.504 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.131594e-01 0.504 0 0
Cellular Senescence R-HSA-2559583 3.137649e-01 0.503 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.199239e-01 0.495 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.199239e-01 0.495 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.199239e-01 0.495 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.199239e-01 0.495 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.199239e-01 0.495 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.199239e-01 0.495 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.199239e-01 0.495 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.199239e-01 0.495 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.266223e-01 0.486 0 0
Acyl chain remodelling of PC R-HSA-1482788 3.266223e-01 0.486 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.266223e-01 0.486 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.280817e-01 0.484 0 0
Synthesis of DNA R-HSA-69239 3.285526e-01 0.483 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.321479e-01 0.479 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.321479e-01 0.479 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.332550e-01 0.477 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.332550e-01 0.477 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.332550e-01 0.477 0 0
Signal amplification R-HSA-392518 3.332550e-01 0.477 0 0
Mitophagy R-HSA-5205647 3.332550e-01 0.477 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.357378e-01 0.474 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.398229e-01 0.469 0 0
Acyl chain remodelling of PE R-HSA-1482839 3.398229e-01 0.469 0 0
Oncogene Induced Senescence R-HSA-2559585 3.398229e-01 0.469 0 0
CaM pathway R-HSA-111997 3.463264e-01 0.461 0 0
Calmodulin induced events R-HSA-111933 3.463264e-01 0.461 0 0
Triglyceride catabolism R-HSA-163560 3.463264e-01 0.461 0 0
RET signaling R-HSA-8853659 3.463264e-01 0.461 0 0
FCERI mediated MAPK activation R-HSA-2871796 3.464729e-01 0.460 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.486742e-01 0.458 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.527663e-01 0.453 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.571515e-01 0.447 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.654575e-01 0.437 0 0
Stabilization of p53 R-HSA-69541 3.654575e-01 0.437 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.654575e-01 0.437 0 0
RAS processing R-HSA-9648002 3.654575e-01 0.437 0 0
Signaling by ALK R-HSA-201556 3.654575e-01 0.437 0 0
Co-inhibition by PD-1 R-HSA-389948 3.674818e-01 0.435 1 1
Cap-dependent Translation Initiation R-HSA-72737 3.677678e-01 0.434 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.677678e-01 0.434 0 0
Rab regulation of trafficking R-HSA-9007101 3.712917e-01 0.430 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.717101e-01 0.430 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.717101e-01 0.430 0 0
HIV Transcription Elongation R-HSA-167169 3.717101e-01 0.430 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.717101e-01 0.430 0 0
Aggrephagy R-HSA-9646399 3.717101e-01 0.430 0 0
Glycogen metabolism R-HSA-8982491 3.717101e-01 0.430 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.717101e-01 0.430 0 0
Interleukin-2 family signaling R-HSA-451927 3.717101e-01 0.430 0 0
Infection with Enterobacteria R-HSA-9640148 3.754990e-01 0.425 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.779014e-01 0.423 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 3.779014e-01 0.423 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.783162e-01 0.422 0 0
Intra-Golgi traffic R-HSA-6811438 3.840321e-01 0.416 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.840321e-01 0.416 0 0
Ca-dependent events R-HSA-111996 3.901028e-01 0.409 0 0
MTOR signalling R-HSA-165159 3.901028e-01 0.409 0 0
TBC/RABGAPs R-HSA-8854214 3.961140e-01 0.402 0 0
Signaling by FGFR4 R-HSA-5654743 3.961140e-01 0.402 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.020656e-01 0.396 0 0
DAG and IP3 signaling R-HSA-1489509 4.079604e-01 0.389 0 0
Nucleosome assembly R-HSA-774815 4.079604e-01 0.389 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.079604e-01 0.389 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.079604e-01 0.389 0 0
Signaling by FGFR3 R-HSA-5654741 4.079604e-01 0.389 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.129253e-01 0.384 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 4.137967e-01 0.383 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.137967e-01 0.383 0 0
Apoptotic execution phase R-HSA-75153 4.137967e-01 0.383 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.195758e-01 0.377 0 0
Metal ion SLC transporters R-HSA-425410 4.252983e-01 0.371 0 0
Plasma lipoprotein remodeling R-HSA-8963899 4.252983e-01 0.371 0 0
Cardiac conduction R-HSA-5576891 4.265056e-01 0.370 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.309647e-01 0.366 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.309647e-01 0.366 0 0
Azathioprine ADME R-HSA-9748787 4.365756e-01 0.360 0 0
Meiotic recombination R-HSA-912446 4.421316e-01 0.354 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.421316e-01 0.354 0 0
The phototransduction cascade R-HSA-2514856 4.421316e-01 0.354 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 4.464495e-01 0.350 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.465662e-01 0.350 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.476330e-01 0.349 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.476330e-01 0.349 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.476330e-01 0.349 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.476330e-01 0.349 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.530806e-01 0.344 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.530806e-01 0.344 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.530806e-01 0.344 0 0
Nucleotide biosynthesis R-HSA-8956320 4.530806e-01 0.344 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.584748e-01 0.339 0 0
Macroautophagy R-HSA-1632852 4.629835e-01 0.334 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.638161e-01 0.334 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.638161e-01 0.334 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.691050e-01 0.329 0 0
Metabolism of amine-derived hormones R-HSA-209776 4.691050e-01 0.329 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.691050e-01 0.329 0 0
Signaling by FGFR1 R-HSA-5654736 4.691050e-01 0.329 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.694709e-01 0.328 0 0
Signaling by NOTCH R-HSA-157118 4.744784e-01 0.324 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.823056e-01 0.317 0 0
Triglyceride metabolism R-HSA-8979227 4.846628e-01 0.315 0 0
S Phase R-HSA-69242 4.886516e-01 0.311 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 4.897474e-01 0.310 0 0
RAB geranylgeranylation R-HSA-8873719 4.897474e-01 0.310 0 0
PLC beta mediated events R-HSA-112043 4.947821e-01 0.306 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 4.949491e-01 0.305 0 0
Signaling by PDGF R-HSA-186797 4.997675e-01 0.301 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.997675e-01 0.301 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.047039e-01 0.297 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.047039e-01 0.297 0 0
Signaling by PTK6 R-HSA-8848021 5.047039e-01 0.297 0 0
Death Receptor Signaling R-HSA-73887 5.073970e-01 0.295 0 0
CD22 mediated BCR regulation R-HSA-5690714 5.095920e-01 0.293 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.095920e-01 0.293 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.104779e-01 0.292 0 0
HIV Life Cycle R-HSA-162587 5.166021e-01 0.287 0 0
G-protein mediated events R-HSA-112040 5.239704e-01 0.281 0 0
Kidney development R-HSA-9830369 5.239704e-01 0.281 0 0
Transcription of the HIV genome R-HSA-167172 5.286694e-01 0.277 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 5.286694e-01 0.277 0 0
Separation of Sister Chromatids R-HSA-2467813 5.376364e-01 0.270 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.379298e-01 0.269 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.379298e-01 0.269 0 0
COPII-mediated vesicle transport R-HSA-204005 5.379298e-01 0.269 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.424919e-01 0.266 0 0
Cellular response to chemical stress R-HSA-9711123 5.426888e-01 0.265 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 5.470093e-01 0.262 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.470093e-01 0.262 0 0
Ca2+ pathway R-HSA-4086398 5.514823e-01 0.258 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.514823e-01 0.258 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.559115e-01 0.255 0 0
Signaling by ERBB4 R-HSA-1236394 5.559115e-01 0.255 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.602971e-01 0.252 0 0
G alpha (s) signalling events R-HSA-418555 5.609000e-01 0.251 0 0
UCH proteinases R-HSA-5689603 5.646398e-01 0.248 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.668559e-01 0.247 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.731976e-01 0.242 0 0
Influenza Infection R-HSA-168255 5.833230e-01 0.234 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.942167e-01 0.226 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.978809e-01 0.223 0 0
Meiosis R-HSA-1500620 6.018546e-01 0.221 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.018546e-01 0.221 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.057893e-01 0.218 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.057893e-01 0.218 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.057893e-01 0.218 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.096853e-01 0.215 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.096853e-01 0.215 0 0
Signaling by WNT R-HSA-195721 6.098417e-01 0.215 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.135430e-01 0.212 0 0
Peptide chain elongation R-HSA-156902 6.173629e-01 0.209 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.285988e-01 0.202 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.285988e-01 0.202 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.322707e-01 0.199 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.359066e-01 0.197 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.359066e-01 0.197 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.381476e-01 0.195 0 0
Mitochondrial protein degradation R-HSA-9837999 6.430715e-01 0.192 0 0
Collagen formation R-HSA-1474290 6.430715e-01 0.192 0 0
Signaling by ROBO receptors R-HSA-376176 6.455040e-01 0.190 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.466012e-01 0.189 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 6.466012e-01 0.189 0 0
Eukaryotic Translation Termination R-HSA-72764 6.500963e-01 0.187 0 0
Transmission across Chemical Synapses R-HSA-112315 6.605948e-01 0.180 0 0
HATs acetylate histones R-HSA-3214847 6.637363e-01 0.178 0 0
Selenocysteine synthesis R-HSA-2408557 6.703569e-01 0.174 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.736184e-01 0.172 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.736184e-01 0.172 0 0
PI Metabolism R-HSA-1483255 6.736184e-01 0.172 0 0
Viral mRNA Translation R-HSA-192823 6.768479e-01 0.170 0 0
Mitotic Anaphase R-HSA-68882 6.782861e-01 0.169 0 0
Opioid Signalling R-HSA-111885 6.800456e-01 0.167 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.800456e-01 0.167 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 6.805313e-01 0.167 0 0
RSV-host interactions R-HSA-9833110 6.832118e-01 0.165 0 0
Nucleotide Excision Repair R-HSA-5696398 6.863470e-01 0.163 0 0
Platelet homeostasis R-HSA-418346 6.894513e-01 0.161 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.925250e-01 0.160 0 0
Gene Silencing by RNA R-HSA-211000 6.925250e-01 0.160 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.925250e-01 0.160 0 0
Signaling by ALK in cancer R-HSA-9700206 6.925250e-01 0.160 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 6.941050e-01 0.159 0 0
Stimuli-sensing channels R-HSA-2672351 6.955685e-01 0.158 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 6.985821e-01 0.156 0 0
Antimicrobial peptides R-HSA-6803157 7.045206e-01 0.152 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 7.074462e-01 0.150 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 7.074462e-01 0.150 0 0
Inositol phosphate metabolism R-HSA-1483249 7.074462e-01 0.150 0 0
Metabolism of nucleotides R-HSA-15869 7.208129e-01 0.142 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.216475e-01 0.142 0 0
Peptide hormone metabolism R-HSA-2980736 7.271344e-01 0.138 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.377876e-01 0.132 0 0
Chromosome Maintenance R-HSA-73886 7.377876e-01 0.132 0 0
MHC class II antigen presentation R-HSA-2132295 7.429582e-01 0.129 0 0
Deubiquitination R-HSA-5688426 7.567582e-01 0.121 0 0
Reproduction R-HSA-1474165 7.650000e-01 0.116 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 7.696371e-01 0.114 0 0
Circadian clock R-HSA-9909396 7.696371e-01 0.114 0 0
Degradation of the extracellular matrix R-HSA-1474228 7.696371e-01 0.114 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 7.808360e-01 0.107 0 0
Ribosome-associated quality control R-HSA-9948299 7.851625e-01 0.105 0 0
Signaling by Hedgehog R-HSA-5358351 7.851625e-01 0.105 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.996477e-01 0.097 0 0
Visual phototransduction R-HSA-2187338 8.055546e-01 0.094 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.055546e-01 0.094 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.150172e-01 0.089 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.186728e-01 0.087 0 0
Phospholipid metabolism R-HSA-1483257 8.196102e-01 0.086 0 0
Cellular response to starvation R-HSA-9711097 8.257701e-01 0.083 0 0
Selenoamino acid metabolism R-HSA-2408522 8.359016e-01 0.078 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.500114e-01 0.071 0 0
Ub-specific processing proteases R-HSA-5689880 8.515027e-01 0.070 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 8.544413e-01 0.068 0 0
Respiratory electron transport R-HSA-611105 8.587412e-01 0.066 0 0
Neuronal System R-HSA-112316 8.641635e-01 0.063 0 0
HCMV Early Events R-HSA-9609690 8.820148e-01 0.055 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.888920e-01 0.051 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 8.899988e-01 0.051 0 0
Metabolism of vitamins and cofactors R-HSA-196854 8.947611e-01 0.048 0 0
Drug ADME R-HSA-9748784 9.062887e-01 0.043 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 9.135106e-01 0.039 0 0
Chromatin modifying enzymes R-HSA-3247509 9.201791e-01 0.036 0 0
G alpha (i) signalling events R-HSA-418594 9.262982e-01 0.033 0 0
Chromatin organization R-HSA-4839726 9.313356e-01 0.031 0 0
HCMV Infection R-HSA-9609646 9.320217e-01 0.031 0 0
Translation R-HSA-72766 9.385149e-01 0.028 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.486967e-01 0.023 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.673970e-01 0.014 0 0
Transport of small molecules R-HSA-382551 9.723204e-01 0.012 0 0
Post-translational protein modification R-HSA-597592 9.740848e-01 0.011 0 0
DNA Repair R-HSA-73894 9.775637e-01 0.010 0 0
Interferon Signaling R-HSA-913531 9.824019e-01 0.008 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.847293e-01 0.007 0 0
Fatty acid metabolism R-HSA-8978868 9.862019e-01 0.006 0 0
GPCR downstream signalling R-HSA-388396 9.862377e-01 0.006 0 0
Metabolism of proteins R-HSA-392499 9.866072e-01 0.006 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.878913e-01 0.005 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.881502e-01 0.005 0 0
Signaling by GPCR R-HSA-372790 9.930184e-01 0.003 0 0
Biological oxidations R-HSA-211859 9.957645e-01 0.002 0 0
Sensory Perception R-HSA-9709957 9.997471e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.998590e-01 0.000 0 0
Metabolism R-HSA-1430728 9.999129e-01 0.000 0 0
Negative regulation of FLT3 R-HSA-9706369 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways