NEK11

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Y Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Log-Odds: Y Sites / Y Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0	S939	Sugiyama	POTEF A26C1B	VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A5A3E0	T949	Sugiyama	POTEF A26C1B	TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
A5A3E0	Y940	Sugiyama	POTEF A26C1B	ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
A6NMY6	T163	Sugiyama	ANXA2P2 ANX2L2 ANX2P2 LPC2B	INRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDG
O15371	T49	Sugiyama	EIF3D EIF3S7	PyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGGSQY
O43242	T69	Sugiyama	PSMD3	GEADGKtAAAAAEHsQRELDtVtLEDIKEHVKQLEKAVSGK
O43242	T71	Sugiyama	PSMD3	ADGKtAAAAAEHsQRELDtVtLEDIKEHVKQLEKAVSGKEP
O43423	T101	Sugiyama	ANP32CP PP32R1	EKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCEV
O43852	T196	Sugiyama	CALU	FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O43852	T89	Sugiyama	CALU	sKERLGKIVSKIDGDKDGFVtVDELKDWIKFAQKRWIyEDV
O60220	S94	Sugiyama	TIMM8A DDP DDP1 TIM8A	SQFILNRLEQTQKSKPVFSEsLsD_________________
O60814	S39	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841	S190	Sugiyama	EIF5B IF2 KIAA0741	NsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGP
O60841	S222	Sugiyama	EIF5B IF2 KIAA0741	KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O60841	T78	Sugiyama	EIF5B IF2 KIAA0741	ILKELEELsLEAQGIKADREtVAVKPTENNEEEFtsKDKKK
O95218	T50	Sugiyama	ZRANB2 ZIS ZNF265	SCNRCGREKTTEAKMMKAGGtEIGKtLAEKSRGLFsANDWQ
O95218	T55	Sugiyama	ZRANB2 ZIS ZNF265	GREKTTEAKMMKAGGtEIGKtLAEKSRGLFsANDWQCKTCs
O95626	T105	Sugiyama	ANP32D PP32R2	EKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCEV
O95678	S162	Sugiyama	KRT75 K6HF KB18	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338	T322	Sugiyama	LDHA PIG19	DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00558	S390	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	IIGGGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPG
P00558	S399	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558	T168	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P02538	S176	Sugiyama	KRT6A K6A KRT6D	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04259	S176	Sugiyama	KRT6B K6B KRTL1	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406	S210	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T211	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406	T246	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05388	T122	Sugiyama	RPLP0	LLANKVPAAARAGAIAPCEVtVPAQNtGLGPEKTSFFQALG
P05388	T128	Sugiyama	RPLP0	PAAARAGAIAPCEVtVPAQNtGLGPEKTSFFQALGItTKIS
P05787	S104	Sugiyama	KRT8 CYK8	IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P06733	T100	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	KKLNVtEQEKIDKLMIEMDGtENKsKFGANAILGVsLAVCK
P06733	T19	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	__MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGA
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733	T26	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195	S320	Sugiyama	LDHB	GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195	T323	Sugiyama	LDHB	sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205	S390	Sugiyama	PGK2 PGKB	VIGGGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPG
P07205	S399	Sugiyama	PGK2 PGKB	CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205	T168	Sugiyama	PGK2 PGKB	EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07355	T163	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	INRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDG
P07437	S75	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
P07437	T72	Sugiyama	TUBB TUBB5 OK/SW-cl.56	NEAtGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
P07737	T65	Sugiyama	PFN1	PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737	Y60	Sugiyama	PFN1	FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07814	S1511	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	PGAKCVCGKNPAKyytLFGRsy___________________
P07814	T1506	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	LCELQPGAKCVCGKNPAKyytLFGRsy______________
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S52	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900	S641	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD
P07900	T645	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKDLVIL
P08729	S104	Sugiyama	KRT7 SCL	LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09382	T58	Sugiyama	LGALS1	DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09651	S360	Sugiyama	HNRNPA1 HNRPA1	PyGGGGQyFAKPRNQGGyGGssssssyGsGRRF________
P09651	S362	Sugiyama	HNRNPA1 HNRPA1	GGGGQyFAKPRNQGGyGGssssssyGsGRRF__________
P09651	S363	Sugiyama	HNRNPA1 HNRPA1	GGGQyFAKPRNQGGyGGssssssyGsGRRF___________
P09923	S111	Sugiyama	ALPI	DRFPYLALSKTYNVDRQVPDsAATATAYLCGVKANFQTIGL
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7	T73	Sugiyama	TUBA3C TUBA2	FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
P0DPH7	T80	Sugiyama	TUBA3C TUBA2	KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAA
P0DPH7	T82	Sugiyama	TUBA3C TUBA2	VPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAANN
P0DPH7	Y83	Sugiyama	TUBA3C TUBA2	PRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAANNy
P10412	S55	Sugiyama	H1-4 H1F4 HIST1H1E	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10809	T117	Sugiyama	HSPD1 HSP60	LVQDVANNtNEEAGDGtttAtVLARSIAKEGFEKISKGANP
P11142	T163	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142	T47	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtNtV
P11142	T64	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142	T66	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P12035	S211	Sugiyama	KRT3	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639	S38	Sugiyama	EEF2 EF2	NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639	S732	Sugiyama	EEF2 EF2	DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13639	T5	Sugiyama	EEF2 EF2	________________MVNFtVDQIRAIMDKKANIRNMsVI
P13639	T735	Sugiyama	EEF2 EF2	HRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCPEQV
P13639	Y730	Sugiyama	EEF2 EF2	HADAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQ
P13647	S181	Sugiyama	KRT5	IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13674	T140	Sugiyama	P4HA1 P4HA	YFPNDEDQVGAAKALLRLQDtyNLDTDtIsKGNLPGVKHKS
P13674	T147	Sugiyama	P4HA1 P4HA	QVGAAKALLRLQDtyNLDTDtIsKGNLPGVKHKSFLTAEDC
P13674	Y141	Sugiyama	P4HA1 P4HA	FPNDEDQVGAAKALLRLQDtyNLDTDtIsKGNLPGVKHKSF
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314	T469	Sugiyama	PRKCSH G19P1	WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14314	Y465	Sugiyama	PRKCSH G19P1	sLGtWGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLC
P14618	T50	Sugiyama	PKM OIP3 PK2 PK3 PKM2	MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P15880	T202	Sugiyama	RPS2 RPS4	CKVTGRCGsVLVRLIPAPRGtGIVsAPVPKKLLMMAGIDDC
P15880	T230	Sugiyama	RPS2 RPS4	PKKLLMMAGIDDCytsARGCtAtLGNFAKATFDAISKTysy
P15880	T232	Sugiyama	RPS2 RPS4	KLLMMAGIDDCytsARGCtAtLGNFAKATFDAISKTysyLt
P16402	S56	Sugiyama	H1-3 H1F3 HIST1H1D	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403	S55	Sugiyama	H1-2 H1F2 HIST1H1C	AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P17066	T228	Sugiyama	HSPA6 HSP70B'	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17066	T49	Sugiyama	HSPA6 HSP70B'	EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P18669	S155	Sugiyama	PGAM1 PGAMA CDABP0006	NIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQI
P18669	T159	Sugiyama	PGAM1 PGAMA CDABP0006	DRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQIKEGK
P20290	T131	Sugiyama	BTF3 NACB OK/SW-cl.8	NQGTVIHFNNPKVQAsLAANtFtItGHAEtKQLTEMLPsIL
P20290	T133	Sugiyama	BTF3 NACB OK/SW-cl.8	GTVIHFNNPKVQAsLAANtFtItGHAEtKQLTEMLPsILNQ
P23528	T63	Sugiyama	CFL1 CFL	DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528	T70	Sugiyama	CFL1 CFL	EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P25786	T11	Sugiyama	PSMA1 HC2 NU PROS30 PSC2	__________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26373	S109	Sugiyama	RPL13 BBC1 OK/SW-cl.46	KVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILFPR
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T148	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373	T151	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26641	T287	Sugiyama	EEF1G EF1G PRO1608	EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29692	S162	Sugiyama	EEF1D EF1D	AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P30050	S157	Sugiyama	RPL12	QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30304	S79	GPS6\|EPSD\|PSP	CDC25A	yEQPLEVKNNSNLQRMGsSEstDsGFCLDsPGPLDSKENLE
P30304	S82	GPS6\|SIGNOR\|EPSD\|PSP	CDC25A	PLEVKNNSNLQRMGsSEstDsGFCLDsPGPLDSKENLENPM
P30304	S88	GPS6\|SIGNOR\|EPSD\|PSP	CDC25A	NSNLQRMGsSEstDsGFCLDsPGPLDSKENLENPMRRIHsL
P31949	T33	Sugiyama	S100A11 MLN70 S100C	CIESLIAVFQKYAGKDGyNytLsKtEFLsFMNTELAAFTKN
P34931	T228	Sugiyama	HSPA1L	DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931	T49	Sugiyama	HSPA1L	EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQNTV
P35579	T1904	Sugiyama	MYH9	EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35579	T1906	Sugiyama	MYH9	AQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRGDL
P35908	S191	Sugiyama	KRT2 KRT2A KRT2E	IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37108	S25	Sugiyama	SRP14	EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37108	T29	Sugiyama	SRP14	FLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGtVEGF
P37108	Y27	Sugiyama	SRP14	EQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGtVE
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38646	T116	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P39019	T36	Sugiyama	RPS19	RALAAFLKKSGKLKVPEWVDtVKLAKHKELAPyDENWFytR
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39687	T105	Sugiyama	ANP32A C15orf1 LANP MAPM PHAP1	EKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCEV
P40429	T153	Sugiyama	RPL13A	RKFAYLGRLAHEVGWKyQAVtAtLEEKRKEKAKIHYRKKKQ
P40429	T155	Sugiyama	RPL13A	FAYLGRLAHEVGWKyQAVtAtLEEKRKEKAKIHYRKKKQLM
P41091	T22	Sugiyama	EIF2S3 EIF2G	AGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAtI
P42766	T64	Sugiyama	RPL35	LsKIRVVRKSIARVLtVINQtQKENLRKFYKGKKyKPLDLR
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P46776	S106	Sugiyama	RPL27A	tRVNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKA
P46776	T72	Sugiyama	RPL27A	yFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRVNAAK
P46776	Y108	Sugiyama	RPL27A	VNAAKNKtGAAPIIDVVRsGyyKVLGKGKLPKQPVIVKAKF
P46777	S172	Sugiyama	RPL5 MSTP030	RTTTGNKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNA
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46777	T177	Sugiyama	RPL5 MSTP030	NKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHRK
P47914	S142	Sugiyama	RPL29	KAKAKAKAKDQTKAQAAAPAsVPAQAPKRtQAPtKAsE___
P48668	S176	Sugiyama	KRT6C KRT6E	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741	T228	Sugiyama	HSPA7 HSP70B	DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P48741	T49	Sugiyama	HSPA7 HSP70B	EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P54132	S338	EPSD\|PSP	BLM RECQ2 RECQL3	CLSTLKDLDtsDRKEDVLstsKDLLSKPEKMsMQELNPEts
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652	T48	Sugiyama	HSPA2	EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTNTI
P57053	S39	Sugiyama	H2BC12L H2BFS H2BS1	VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876	S39	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174	T217	Sugiyama	TPI1 TPI	VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174	T38	Sugiyama	TPI1 TPI	RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60174	T46	Sugiyama	TPI1 TPI	IGtLNAAKVPADtEVVCAPPtAyIDFARQKLDPKIAVAAQN
P60174	T90	Sugiyama	TPI1 TPI	VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S239	Sugiyama	ACTB	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709	S323	Sugiyama	ACTB	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709	T249	Sugiyama	ACTB	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709	T297	Sugiyama	ACTB	TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P60709	T304	Sugiyama	ACTB	KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P60709	T318	Sugiyama	ACTB	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709	T324	Sugiyama	ACTB	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709	Y240	Sugiyama	ACTB	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709	Y53	Sugiyama	ACTB	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61247	S263	Sugiyama	RPS3A FTE1 MFTL	GDEtGAKVERADGyEPPVQEsV___________________
P61254	T8	Sugiyama	RPL26	_____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61254	T93	Sugiyama	RPL26	VYRKKyVIyIERVQREKANGttVHVGIHPSKVVITRLKLDK
P61254	T94	Sugiyama	RPL26	YRKKyVIyIERVQREKANGttVHVGIHPSKVVITRLKLDKD
P61353	T94	Sugiyama	RPL27	VyNyNHLMPtRysVDIPLDKtVVNKDVFRDPALKRKARREA
P61978	S401	Sugiyama	HNRNPK HNRPK	GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280	T15	Sugiyama	RPS11	______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62280	T54	Sugiyama	RPS11	PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62316	T40	Sugiyama	SNRPD2 SNRPD1	EEEEFNtGPLsVLtQsVKNNtQVLINCRNNKKLLGRVKAFD
P62424	T84	Sugiyama	RPL7A SURF-3 SURF3	QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62736	S241	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736	S325	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736	T251	Sugiyama	ACTA2 ACTSA ACTVS GIG46	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736	T320	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736	T326	Sugiyama	ACTA2 ACTSA ACTVS GIG46	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736	Y242	Sugiyama	ACTA2 ACTSA ACTVS GIG46	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62736	Y55	Sugiyama	ACTA2 ACTSA ACTVS GIG46	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62753	T127	Sugiyama	RPS6 OK/SW-cl.2	SVLNLVIVKKGEKDIPGLtDttVPRRLGPKRASRIRKLFNL
P62807	S39	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62826	T66	Sugiyama	RAN ARA24 OK/SW-cl.81	EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62899	T119	Sugiyama	RPL31	PNKLytLVtyVPVttFKNLQtVNVDEN______________
P62899	T22	Sugiyama	RPL31	APAKKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRA
P62899	T26	Sugiyama	RPL31	KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62917	T135	Sugiyama	RPL8	CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917	T146	Sugiyama	RPL8	LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917	Y133	Sugiyama	RPL8	VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62937	T157	Sugiyama	PPIA CYPA	NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62942	T7	Sugiyama	FKBP1A FKBP1 FKBP12	______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62979	S134	Sugiyama	RPS27A UBA80 UBCEP1	IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P62979	T147	Sugiyama	RPS27A UBA80 UBCEP1	GAGVFMAsHFDRHyCGKCCLtyCFNKPEDK___________
P63173	T14	Sugiyama	RPL38	_______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S239	Sugiyama	ACTG1 ACTG	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261	S323	Sugiyama	ACTG1 ACTG	ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261	T249	Sugiyama	ACTG1 ACTG	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261	T297	Sugiyama	ACTG1 ACTG	TTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEI
P63261	T304	Sugiyama	ACTG1 ACTG	KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P63261	T318	Sugiyama	ACTG1 ACTG	VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261	T324	Sugiyama	ACTG1 ACTG	tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261	Y240	Sugiyama	ACTG1 ACTG	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261	Y53	Sugiyama	ACTG1 ACTG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267	S240	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267	S324	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267	T250	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267	T319	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267	T325	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267	Y241	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63267	Y54	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032	S241	Sugiyama	ACTC1 ACTC	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032	S325	Sugiyama	ACTC1 ACTC	tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032	T251	Sugiyama	ACTC1 ACTC	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032	T320	Sugiyama	ACTC1 ACTC	VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032	T326	Sugiyama	ACTC1 ACTC	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032	Y242	Sugiyama	ACTC1 ACTC	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032	Y55	Sugiyama	ACTC1 ACTC	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104	T261	Sugiyama	EEF1A1 EEF1A EF1A LENG7	PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
P68133	S241	Sugiyama	ACTA1 ACTA	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133	S325	Sugiyama	ACTA1 ACTA	TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	T251	Sugiyama	ACTA1 ACTA	tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133	T320	Sugiyama	ACTA1 ACTA	VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133	T326	Sugiyama	ACTA1 ACTA	TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133	Y242	Sugiyama	ACTA1 ACTA	ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133	Y55	Sugiyama	ACTA1 ACTA	sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731	S7	Sugiyama	RPL24	______________MKVELCsFsGyKIYPGHGRRYARTDGK
P84098	S37	Sugiyama	RPL19	CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098	T29	Sugiyama	RPL19	RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q01105	S165	Sugiyama	SET	PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q01546	S196	Sugiyama	KRT76 KRT2B KRT2P	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q05639	T261	Sugiyama	EEF1A2 EEF1AL STN	PTDKPLRLPLQDVyKIGGIGtVPVGRVETGILRPGMVVTFA
Q07020	S140	Sugiyama	RPL18	ILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAPGtPH
Q07020	T136	Sugiyama	RPL18	AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07020	T79	Sugiyama	RPL18	PPLsLsRMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLK
Q07020	T85	Sugiyama	RPL18	RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q13509	S75	Sugiyama	TUBB3 TUBB4	SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS
Q13509	T72	Sugiyama	TUBB3 TUBB4	NEASSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIF
Q13885	S75	Sugiyama	TUBB2A TUBB2	AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q13885	T72	Sugiyama	TUBB2A TUBB2	NEAAGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
Q14157	T256	Sugiyama	UBAP2L KIAA0144 NICE4	AWRtAtEEWGtEDWNEDLsEtKIFtAsNVssVPLPAENVtI
Q14192	T234	Sugiyama	FHL2 DRAL SLIM3	CDLyAKKCAGCTNPISGLGGtKyIsFEERQWHNDCFNCKKC
Q14568	S52	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14CN4	S138	Sugiyama	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15185	T69	Sugiyama	PTGES3 P23 TEBP	HLNEIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRL
Q2VIR3	T22	Sugiyama	EIF2S3B	AGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAtI
Q3SY84	S143	Sugiyama	KRT71 K6IRS1 KB34 KRT6IRS1	IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q562R1	S240	Sugiyama	ACTBL2	VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q562R1	T250	Sugiyama	ACTBL2	RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q562R1	Y241	Sugiyama	ACTBL2	ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q5QNW6	S39	Sugiyama	H2BC18 HIST2H2BF	VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5VTE0	T261	Sugiyama	EEF1A1P5 EEF1AL3	PTDKPLRLPLQDVyKIGGIGtVPVGRVEtGVLKPGMVVtFA
Q5XKE5	S155	Sugiyama	KRT79 K6L KB38 KRT6L	IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6PEY2	T73	Sugiyama	TUBA3E	FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
Q6PEY2	T80	Sugiyama	TUBA3E	KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAA
Q6PEY2	T82	Sugiyama	TUBA3E	VPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAASN
Q6PEY2	Y83	Sugiyama	TUBA3E	PRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAASNY
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3	S939	Sugiyama	POTEE A26C1A POTE2	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6S8J3	T949	Sugiyama	POTEE A26C1A POTE2	tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q6S8J3	Y940	Sugiyama	POTEE A26C1A POTE2	ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZN18	S206	Sugiyama	AEBP2	DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q7RTS7	S153	Sugiyama	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z794	S177	Sugiyama	KRT77 KRT1B	IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86Y46	S145	Sugiyama	KRT73 K6IRS3 KB36 KRT6IRS3	IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8NFD5	S1744	Sugiyama	ARID1B BAF250B DAN15 KIAA1235 OSA2	ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8NG66	S12	Sugiyama	NEK11	_________MLKFQEAAKCVsGStAIStyPKtLIARRYVLQ
Q8NG66	S251	Sugiyama	NEK11	AFAGSNFLSIVLKIVEGDtPsLPERYPKELNAIMESMLNKN
Q8NG66	S37	Sugiyama	NEK11	IStyPKtLIARRYVLQQKLGsGsFGtVYLVSDKKAKRGEEL
Q8NG66	S39	Sugiyama	NEK11	tyPKtLIARRYVLQQKLGsGsFGtVYLVSDKKAKRGEELKV
Q8NG66	S412	Sugiyama	NEK11	HEKTHLKGMEEKEEQPEGRLsCsPQDEDEERWQGREEESDE
Q8NG66	S414	Sugiyama	NEK11	KTHLKGMEEKEEQPEGRLsCsPQDEDEERWQGREEESDEPT
Q8NG66	S511	Sugiyama	NEK11	DEEEEEIALERPEKEIRNEGsQPAyRtNQQDsDIEALARCL
Q8NG66	S522	Sugiyama	NEK11	PEKEIRNEGsQPAyRtNQQDsDIEALARCLENVLGCTSLDT
Q8NG66	S64	Sugiyama	NEK11	YLVSDKKAKRGEELKVLKEIsVGELNPNEtVQANLEAQLLS
Q8NG66	T15	Sugiyama	NEK11	______MLKFQEAAKCVsGStAIStyPKtLIARRYVLQQKL
Q8NG66	T19	Sugiyama	NEK11	__MLKFQEAAKCVsGStAIStyPKtLIARRYVLQQKLGsGs
Q8NG66	T23	Sugiyama	NEK11	KFQEAAKCVsGStAIStyPKtLIARRYVLQQKLGsGsFGtV
Q8NG66	T249	Sugiyama	NEK11	NHAFAGSNFLSIVLKIVEGDtPsLPERYPKELNAIMESMLN
Q8NG66	T302	Sugiyama	NEK11	LKIPYLDEQLQNLMCRYSEMtLEDKNLDCQKEAAHIINAMQ
Q8NG66	T42	Sugiyama	NEK11	KtLIARRYVLQQKLGsGsFGtVYLVSDKKAKRGEELKVLKE
Q8NG66	T517	Sugiyama	NEK11	IALERPEKEIRNEGsQPAyRtNQQDsDIEALARCLENVLGC
Q8NG66	T73	Sugiyama	NEK11	RGEELKVLKEIsVGELNPNEtVQANLEAQLLSKLDHPAIVK
Q8NG66	Y20	Sugiyama	NEK11	_MLKFQEAAKCVsGStAIStyPKtLIARRYVLQQKLGsGsF
Q8NG66	Y515	Sugiyama	NEK11	EEIALERPEKEIRNEGsQPAyRtNQQDsDIEALARCLENVL
Q8NHW5	T122	Sugiyama	RPLP0P6	LLANKVPAAARAGAIAPCEVtVPAQNtGLGPEKTSFFQALG
Q8NHW5	T128	Sugiyama	RPLP0P6	PAAARAGAIAPCEVtVPAQNtGLGPEKTSFFQALGItTKIS
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TD08	S415	Sugiyama	MAPK15 ERK7 ERK8	GHDPAEHESPRAAKNVPRQNsAPLLQtALLGNGERPPGAKE
Q8TD08	T421	Sugiyama	MAPK15 ERK7 ERK8	HESPRAAKNVPRQNsAPLLQtALLGNGERPPGAKEAPPLtL
Q93079	S39	Sugiyama	H2BC9 H2BFJ HIST1H2BH	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99832	S59	Sugiyama	CCT7 CCTH NIP7-1	TLGPRGMDKLIVDGRGKAtIsNDGAtILKLLDVVHPAAKTL
Q99832	T64	Sugiyama	CCT7 CCTH NIP7-1	GMDKLIVDGRGKAtIsNDGAtILKLLDVVHPAAKTLVDIAK
Q99848	S270	Sugiyama	EBNA1BP2 EBP2	FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q99877	S39	Sugiyama	H2BC15 H2BFD HIST1H2BN	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879	S39	Sugiyama	H2BC14 H2BFE HIST1H2BM	INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880	S39	Sugiyama	H2BC13 H2BFC HIST1H2BL	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BRS2	S507	Sugiyama	RIOK1 RIO1	ENQVEERtCsDsEDIGssECsDtDSEEQGDHARPKKHTTDP
Q9BVA1	S75	Sugiyama	TUBB2B	tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs
Q9BVA1	T72	Sugiyama	TUBB2B	NEAtGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF
Q9BYX7	S239	Sugiyama	POTEKP ACTBL3 FKSG30	VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7	T249	Sugiyama	POTEKP ACTBL3 FKSG30	MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9BYX7	Y240	Sugiyama	POTEKP ACTBL3 FKSG30	ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9H173	T125	Sugiyama	SIL1 UNQ545/PRO836	QYEDKFRNNLKGKRLDINtNtytsQDLKSALAKFKEGAEME
Q9NSB2	S178	Sugiyama	KRT84 KRTHB4	AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9UNF1	T92	Sugiyama	MAGED2 BCG1	tPEAREAPAtQAssttQLtDtQVLAAENKSLAADTKKQNAD
Q9UNX3	T8	Sugiyama	RPL26L1 RPL26P1	_____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UNX3	T93	Sugiyama	RPL26L1 RPL26P1	VYRKKyVIyIERVQREKANGttVHVGIHPSKVVITRLKLDK
Q9UNX3	T94	Sugiyama	RPL26L1 RPL26P1	YRKKyVIyIERVQREKANGttVHVGIHPSKVVITRLKLDKD
Q9UPQ0	S377	Sugiyama	LIMCH1 KIAA1102	LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ35	S2692	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y2B0	T132	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	NGEssELDLQGIRIDsDISGtLKFACEsIVEEyEDELIEFF
Q9Y2T7	T143	Sugiyama	YBX2 CSDA3 MSY2	QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y2W1	T227	Sugiyama	THRAP3 BCLAF2 TRAP150	sGGtsQDTKAsEssKPWPDAtyGtGsAsRAsAVsELsPRER
Q9Y2W1	T230	Sugiyama	THRAP3 BCLAF2 TRAP150	tsQDTKAsEssKPWPDAtyGtGsAsRAsAVsELsPRERsPA
Q9Y5L4	S57	Sugiyama	TIMM13 TIM13B TIMM13A TIMM13B	ELLQRMTDKCFRKCIGKPGGsLDNSEQKCIAMCMDRyMDAW

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Post NMDA receptor activation events	R-HSA-438064	3.762540e-10	9.425
Aggrephagy	R-HSA-9646399	1.457108e-09	8.837
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.626369e-09	8.789
Apoptotic execution phase	R-HSA-75153	1.431647e-09	8.844
M Phase	R-HSA-68886	2.274501e-09	8.643
Cell Cycle, Mitotic	R-HSA-69278	3.516001e-09	8.454
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	5.793842e-09	8.237
Axon guidance	R-HSA-422475	5.590868e-09	8.253
Signal Transduction	R-HSA-162582	1.071741e-08	7.970
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.881927e-08	7.725
Nervous system development	R-HSA-9675108	2.197763e-08	7.658
Selective autophagy	R-HSA-9663891	5.871088e-08	7.231
Mitotic Prometaphase	R-HSA-68877	1.398553e-07	6.854
Cell Cycle	R-HSA-1640170	1.509157e-07	6.821
Apoptosis	R-HSA-109581	1.927939e-07	6.715
Autophagy	R-HSA-9612973	3.471501e-07	6.459
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	4.524682e-07	6.344
Programmed Cell Death	R-HSA-5357801	4.760326e-07	6.322
ISG15 antiviral mechanism	R-HSA-1169408	6.209839e-07	6.207
G2/M Transition	R-HSA-69275	7.191136e-07	6.143
Separation of Sister Chromatids	R-HSA-2467813	7.918611e-07	6.101
Mitotic G2-G2/M phases	R-HSA-453274	8.658803e-07	6.063
Downregulation of ERBB4 signaling	R-HSA-1253288	1.128074e-06	5.948
Mitotic Anaphase	R-HSA-68882	1.240529e-06	5.906
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.348905e-06	5.870
Downregulation of ERBB2 signaling	R-HSA-8863795	1.479586e-06	5.830
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.629592e-06	5.788
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.918627e-06	5.717
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	2.064787e-06	5.685
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.477264e-06	5.606
Macroautophagy	R-HSA-1632852	2.488422e-06	5.604
Long-term potentiation	R-HSA-9620244	2.750202e-06	5.561
Regulation of CDH1 Function	R-HSA-9764561	3.390202e-06	5.470
Apoptosis induced DNA fragmentation	R-HSA-140342	3.353330e-06	5.475
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	3.846506e-06	5.415
DNA Damage Bypass	R-HSA-73893	4.109243e-06	5.386
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	4.034734e-06	5.394
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.478098e-06	5.349
L1CAM interactions	R-HSA-373760	5.007667e-06	5.300
MAPK family signaling cascades	R-HSA-5683057	6.236650e-06	5.205
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	7.189817e-06	5.143
Late Phase of HIV Life Cycle	R-HSA-162599	9.808917e-06	5.008
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.165540e-05	4.933
Signaling by VEGF	R-HSA-194138	1.439239e-05	4.842
Recycling pathway of L1	R-HSA-437239	1.471650e-05	4.832
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	1.571821e-05	4.804
Chaperone Mediated Autophagy	R-HSA-9613829	1.592905e-05	4.798
Nuclear Envelope Breakdown	R-HSA-2980766	1.621041e-05	4.790
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.819344e-05	4.740
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.869475e-05	4.728
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	1.893326e-05	4.723
Transport of the SLBP independent Mature mRNA	R-HSA-159227	1.964783e-05	4.707
Translesion Synthesis by POLH	R-HSA-110320	2.150427e-05	4.667
Interferon Signaling	R-HSA-913531	2.228774e-05	4.652
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.428927e-05	4.615
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.547654e-05	4.594
Hedgehog 'off' state	R-HSA-5610787	2.650668e-05	4.577
Cell-Cell communication	R-HSA-1500931	2.984908e-05	4.525
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.018847e-05	4.520
Cell-extracellular matrix interactions	R-HSA-446353	3.760747e-05	4.425
HIV Life Cycle	R-HSA-162587	3.710843e-05	4.431
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	3.886458e-05	4.410
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.011430e-05	4.397
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	4.353989e-05	4.361
Membrane Trafficking	R-HSA-199991	4.455025e-05	4.351
Signaling by Hedgehog	R-HSA-5358351	5.818684e-05	4.235
SARS-CoV-2-host interactions	R-HSA-9705683	5.935354e-05	4.227
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	7.680995e-05	4.115
Evasion by RSV of host interferon responses	R-HSA-9833109	7.536965e-05	4.123
NS1 Mediated Effects on Host Pathways	R-HSA-168276	7.680995e-05	4.115
Cytokine Signaling in Immune system	R-HSA-1280215	8.616718e-05	4.065
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	9.141425e-05	4.039
Cellular response to heat stress	R-HSA-3371556	8.972530e-05	4.047
Apoptotic cleavage of cellular proteins	R-HSA-111465	9.199738e-05	4.036
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.314929e-05	4.031
Cell junction organization	R-HSA-446728	9.415384e-05	4.026
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.006504e-04	3.997
Signaling by ERBB2	R-HSA-1227986	1.093733e-04	3.961
MAPK1/MAPK3 signaling	R-HSA-5684996	1.141524e-04	3.943
Transport of connexons to the plasma membrane	R-HSA-190872	1.222026e-04	3.913
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.452751e-04	3.838
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.500957e-04	3.824
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.593442e-04	3.798
Nuclear import of Rev protein	R-HSA-180746	1.613823e-04	3.792
RAF/MAP kinase cascade	R-HSA-5673001	1.741326e-04	3.759
SARS-CoV-2 Infection	R-HSA-9694516	1.741650e-04	3.759
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	1.880792e-04	3.726
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	1.880792e-04	3.726
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.924959e-04	3.716
Post-chaperonin tubulin folding pathway	R-HSA-389977	2.023633e-04	3.694
Chaperonin-mediated protein folding	R-HSA-390466	2.171017e-04	3.663
Signaling by NOTCH3	R-HSA-9012852	2.283162e-04	3.641
Calmodulin induced events	R-HSA-111933	2.284440e-04	3.641
CaM pathway	R-HSA-111997	2.284440e-04	3.641
Cellular responses to stimuli	R-HSA-8953897	2.305179e-04	3.637
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.332844e-04	3.632
Translesion synthesis by REV1	R-HSA-110312	3.055137e-04	3.515
Termination of translesion DNA synthesis	R-HSA-5656169	2.826031e-04	3.549
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.751411e-04	3.560
Signaling downstream of RAS mutants	R-HSA-9649948	2.751411e-04	3.560
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.751411e-04	3.560
PKR-mediated signaling	R-HSA-9833482	3.189165e-04	3.496
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	2.982929e-04	3.525
Deubiquitination	R-HSA-5688426	3.038926e-04	3.517
Signaling by RAS mutants	R-HSA-6802949	2.751411e-04	3.560
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.171569e-04	3.499
Ovarian tumor domain proteases	R-HSA-5689896	2.697940e-04	3.569
Signaling by CSF3 (G-CSF)	R-HSA-9674555	2.826031e-04	3.549
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	3.189165e-04	3.496
Spry regulation of FGF signaling	R-HSA-1295596	3.055137e-04	3.515
Regulated Necrosis	R-HSA-5218859	2.982929e-04	3.525
p75NTR signals via NF-kB	R-HSA-193639	3.055137e-04	3.515
Glycolysis	R-HSA-70171	2.925025e-04	3.534
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	3.204159e-04	3.494
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	3.204159e-04	3.494
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	3.204159e-04	3.494
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	3.204159e-04	3.494
FLT3 signaling by CBL mutants	R-HSA-9706377	3.571915e-04	3.447
Translesion synthesis by POLI	R-HSA-5656121	3.997742e-04	3.398
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.401271e-04	3.468
Protein folding	R-HSA-391251	3.949051e-04	3.404
Regulation of TP53 Expression and Degradation	R-HSA-6806003	3.711886e-04	3.430
Josephin domain DUBs	R-HSA-5689877	4.019178e-04	3.396
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.972837e-04	3.401
Pexophagy	R-HSA-9664873	4.019178e-04	3.396
Regulation of NF-kappa B signaling	R-HSA-9758274	3.997742e-04	3.398
Negative regulation of FLT3	R-HSA-9706369	3.997742e-04	3.398
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	4.068499e-04	3.391
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	4.068499e-04	3.391
Gap junction trafficking and regulation	R-HSA-157858	4.179842e-04	3.379
Kinesins	R-HSA-983189	4.306073e-04	3.366
Interactions of Rev with host cellular proteins	R-HSA-177243	4.325900e-04	3.364
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.678870e-04	3.330
FLT3 Signaling	R-HSA-9607240	5.021085e-04	3.299
Translesion synthesis by POLK	R-HSA-5655862	5.153374e-04	3.288
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	5.153374e-04	3.288
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.211252e-04	3.283
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.605459e-04	3.251
IPs transport between nucleus and cytosol	R-HSA-1855170	5.722264e-04	3.242
Signaling by NOTCH4	R-HSA-9013694	5.793687e-04	3.237
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	5.722264e-04	3.242
Negative regulation of MAPK pathway	R-HSA-5675221	5.805387e-04	3.236
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	5.859490e-04	3.232
Amplification of signal from the kinetochores	R-HSA-141424	5.859490e-04	3.232
Maturation of protein E	R-HSA-9683683	5.874913e-04	3.231
Maturation of protein E	R-HSA-9694493	5.874913e-04	3.231
Death Receptor Signaling	R-HSA-73887	5.919662e-04	3.228
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	6.121024e-04	3.213
Signaling by PTK6	R-HSA-8848021	6.121024e-04	3.213
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	6.450450e-04	3.190
Ca-dependent events	R-HSA-111996	6.687223e-04	3.175
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	6.732286e-04	3.172
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	7.620746e-04	3.118
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	7.620746e-04	3.118
NF-kB is activated and signals survival	R-HSA-209560	7.620746e-04	3.118
Mitophagy	R-HSA-5205647	7.881265e-04	3.103
Mitotic Prophase	R-HSA-68875	7.017414e-04	3.154
HIV Infection	R-HSA-162906	7.381958e-04	3.132
p75 NTR receptor-mediated signalling	R-HSA-193704	8.143861e-04	3.089
Regulation of CDH1 Expression and Function	R-HSA-9764265	8.758840e-04	3.058
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	8.758840e-04	3.058
Gap junction trafficking	R-HSA-190828	8.779556e-04	3.057
Mitotic Spindle Checkpoint	R-HSA-69618	8.867124e-04	3.052
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	8.904706e-04	3.050
Oncogene Induced Senescence	R-HSA-2559585	9.182753e-04	3.037
Host Interactions of HIV factors	R-HSA-162909	9.500943e-04	3.022
Signaling by EGFR	R-HSA-177929	1.000790e-03	3.000
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.000928e-03	3.000
DAG and IP3 signaling	R-HSA-1489509	1.000928e-03	3.000
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.013284e-03	2.994
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	1.013284e-03	2.994
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	1.013284e-03	2.994
p75NTR recruits signalling complexes	R-HSA-209543	1.013284e-03	2.994
Regulation of signaling by CBL	R-HSA-912631	1.022259e-03	2.990
Regulation of TP53 Degradation	R-HSA-6804757	1.065101e-03	2.973
Intracellular signaling by second messengers	R-HSA-9006925	1.070335e-03	2.970
Regulation of TNFR1 signaling	R-HSA-5357905	1.137499e-03	2.944
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.288749e-03	2.890
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.230100e-03	2.910
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.137499e-03	2.944
Glycogen synthesis	R-HSA-3322077	1.256429e-03	2.901
Membrane binding and targetting of GAG proteins	R-HSA-174490	1.321252e-03	2.879
Cellular Senescence	R-HSA-2559583	1.333351e-03	2.875
Regulation of PTEN localization	R-HSA-8948747	1.333471e-03	2.875
Cellular responses to stress	R-HSA-2262752	1.360621e-03	2.866
HCMV Early Events	R-HSA-9609690	1.443666e-03	2.841
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.443666e-03	2.841
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	1.750188e-03	2.757
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.529531e-03	2.815
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.529531e-03	2.815
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.566087e-03	2.805
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.639836e-03	2.785
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.559670e-03	2.807
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.559670e-03	2.807
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.559670e-03	2.807
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.559670e-03	2.807
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.693298e-03	2.771
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.559670e-03	2.807
Cell Cycle Checkpoints	R-HSA-69620	1.658041e-03	2.780
Glucose metabolism	R-HSA-70326	1.521843e-03	2.818
Clathrin-mediated endocytosis	R-HSA-8856828	1.794439e-03	2.746
Transmission across Chemical Synapses	R-HSA-112315	1.835889e-03	2.736
COPI-mediated anterograde transport	R-HSA-6807878	1.842681e-03	2.735
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.842681e-03	2.735
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.845600e-03	2.734
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.850107e-03	2.733
ROBO receptors bind AKAP5	R-HSA-9010642	1.882626e-03	2.725
Myoclonic epilepsy of Lafora	R-HSA-3785653	1.882626e-03	2.725
Modulation by Mtb of host immune system	R-HSA-9637628	1.882626e-03	2.725
Signaling by ERBB4	R-HSA-1236394	1.902489e-03	2.721
Golgi-to-ER retrograde transport	R-HSA-8856688	1.915135e-03	2.718
tRNA processing in the nucleus	R-HSA-6784531	1.921655e-03	2.716
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.921655e-03	2.716
EGFR downregulation	R-HSA-182971	1.960794e-03	2.708
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.960794e-03	2.708
Ub-specific processing proteases	R-HSA-5689880	2.058449e-03	2.686
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.104095e-03	2.677
Signaling by ROBO receptors	R-HSA-376176	2.104129e-03	2.677
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.107963e-03	2.676
MyD88-independent TLR4 cascade	R-HSA-166166	2.107963e-03	2.676
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.126509e-03	2.672
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.126509e-03	2.672
Semaphorin interactions	R-HSA-373755	2.126509e-03	2.672
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.136924e-03	2.670
Signaling by RAF1 mutants	R-HSA-9656223	2.384717e-03	2.623
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.588905e-03	2.587
Degradation of GLI1 by the proteasome	R-HSA-5610780	2.384717e-03	2.623
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	2.571309e-03	2.590
Regulation of necroptotic cell death	R-HSA-5675482	2.620613e-03	2.582
Degradation of GLI2 by the proteasome	R-HSA-5610783	2.384717e-03	2.623
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	2.384717e-03	2.623
Signaling by NOTCH1	R-HSA-1980143	2.285462e-03	2.641
Cell-cell junction organization	R-HSA-421270	2.462717e-03	2.609
Adherens junctions interactions	R-HSA-418990	2.206109e-03	2.656
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	2.620613e-03	2.582
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	2.659756e-03	2.575
Transcriptional Regulation by TP53	R-HSA-3700989	2.820295e-03	2.550
AURKA Activation by TPX2	R-HSA-8854518	2.848524e-03	2.545
Influenza Infection	R-HSA-168255	2.869457e-03	2.542
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.093793e-03	2.510
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	3.093793e-03	2.510
Neuronal System	R-HSA-112316	3.113360e-03	2.507
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	3.269485e-03	2.486
Folding of actin by CCT/TriC	R-HSA-390450	3.415584e-03	2.467
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	3.415584e-03	2.467
RAF activation	R-HSA-5673000	3.438932e-03	2.464
Gap junction assembly	R-HSA-190861	3.438932e-03	2.464
TNF signaling	R-HSA-75893	3.511080e-03	2.455
Vesicle-mediated transport	R-HSA-5653656	3.808647e-03	2.419
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	3.822560e-03	2.418
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.894076e-03	2.410
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.897463e-03	2.409
Regulation of FZD by ubiquitination	R-HSA-4641263	3.973821e-03	2.401
Signaling by EGFR in Cancer	R-HSA-1643713	4.219747e-03	2.375
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.219747e-03	2.375
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	4.430908e-03	2.354
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	4.477064e-03	2.349
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	4.477064e-03	2.349
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	4.484867e-03	2.348
NrCAM interactions	R-HSA-447038	4.484867e-03	2.348
PKA activation in glucagon signalling	R-HSA-164378	4.780429e-03	2.321
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	5.696889e-03	2.244
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.884353e-03	2.311
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	5.014065e-03	2.300
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	5.300461e-03	2.276
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	5.300461e-03	2.276
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	4.702374e-03	2.328
Oncogenic MAPK signaling	R-HSA-6802957	4.852891e-03	2.314
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	4.884353e-03	2.311
Regulation of TP53 Activity	R-HSA-5633007	4.854955e-03	2.314
Regulation of TP53 Activity through Methylation	R-HSA-6804760	4.780429e-03	2.321
PKA activation	R-HSA-163615	4.780429e-03	2.321
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	5.622778e-03	2.250
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.787619e-03	2.320
RIPK1-mediated regulated necrosis	R-HSA-5213460	5.643722e-03	2.248
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	5.674004e-03	2.246
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.622778e-03	2.250
Viral Messenger RNA Synthesis	R-HSA-168325	5.656580e-03	2.247
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	5.405139e-03	2.267
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	5.405139e-03	2.267
Transcriptional regulation by small RNAs	R-HSA-5578749	4.873984e-03	2.312
MAPK6/MAPK4 signaling	R-HSA-5687128	4.852891e-03	2.314
PLC beta mediated events	R-HSA-112043	5.656580e-03	2.247
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.816225e-03	2.235
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.816225e-03	2.235
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.816225e-03	2.235
Rap1 signalling	R-HSA-392517	5.696889e-03	2.244
Centrosome maturation	R-HSA-380287	6.240670e-03	2.205
Late endosomal microautophagy	R-HSA-9615710	6.439572e-03	2.191
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	6.439572e-03	2.191
Signaling by ERBB2 KD Mutants	R-HSA-9664565	6.439572e-03	2.191
Negative regulation of FGFR4 signaling	R-HSA-5654733	6.439572e-03	2.191
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	6.470229e-03	2.189
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	6.470229e-03	2.189
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.628131e-03	2.179
Negative regulation of MET activity	R-HSA-6807004	6.730646e-03	2.172
IRAK1 recruits IKK complex	R-HSA-937039	7.032651e-03	2.153
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	7.032651e-03	2.153
VLDLR internalisation and degradation	R-HSA-8866427	7.032651e-03	2.153
Negative regulation of NOTCH4 signaling	R-HSA-9604323	7.078157e-03	2.150
Glycogen metabolism	R-HSA-8982491	7.078157e-03	2.150
Signaling by ERBB2 in Cancer	R-HSA-1227990	7.339264e-03	2.134
G alpha (12/13) signalling events	R-HSA-416482	7.888361e-03	2.103
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	7.888964e-03	2.103
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.888964e-03	2.103
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	7.888964e-03	2.103
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.888964e-03	2.103
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	8.843290e-03	2.053
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	8.904465e-03	2.050
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	1.048327e-02	1.980
MAP2K and MAPK activation	R-HSA-5674135	8.766449e-03	2.057
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.048327e-02	1.980
Trafficking of AMPA receptors	R-HSA-399719	8.326340e-03	2.080
DNA Double Strand Break Response	R-HSA-5693606	9.430369e-03	2.025
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.326340e-03	2.080
Listeria monocytogenes entry into host cells	R-HSA-8876384	9.178890e-03	2.037
HCMV Infection	R-HSA-9609646	9.163684e-03	2.038
Cilium Assembly	R-HSA-5617833	1.043173e-02	1.982
G-protein mediated events	R-HSA-112040	9.430369e-03	2.025
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.058028e-02	1.976
NRIF signals cell death from the nucleus	R-HSA-205043	1.048327e-02	1.980
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.215297e-03	2.085
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.058028e-02	1.976
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.977227e-03	2.098
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.048327e-02	1.980
Assembly Of The HIV Virion	R-HSA-175474	9.178890e-03	2.037
EPH-Ephrin signaling	R-HSA-2682334	9.305691e-03	2.031
Viral Infection Pathways	R-HSA-9824446	9.314823e-03	2.031
HDL assembly	R-HSA-8963896	1.048327e-02	1.980
SARS-CoV-1-host interactions	R-HSA-9692914	1.044073e-02	1.981
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	9.178890e-03	2.037
Translation of Structural Proteins	R-HSA-9683701	8.766449e-03	2.057
SARS-CoV Infections	R-HSA-9679506	8.744795e-03	2.058
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.060721e-02	1.974
Neutrophil degranulation	R-HSA-6798695	1.076327e-02	1.968
SARS-CoV-1 Infection	R-HSA-9678108	1.077064e-02	1.968
Developmental Biology	R-HSA-1266738	1.082988e-02	1.965
Toll-like Receptor Cascades	R-HSA-168898	1.090353e-02	1.962
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.109280e-02	1.955
Signaling by ALK in cancer	R-HSA-9700206	1.109280e-02	1.955
NRAGE signals death through JNK	R-HSA-193648	1.116232e-02	1.952
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.177584e-02	1.929
Cation-coupled Chloride cotransporters	R-HSA-426117	1.180722e-02	1.928
ER to Golgi Anterograde Transport	R-HSA-199977	1.183582e-02	1.927
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.218044e-02	1.914
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.249075e-02	1.903
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.255586e-02	1.901
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.255586e-02	1.901
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	1.255586e-02	1.901
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	1.255586e-02	1.901
DNA Repair	R-HSA-73894	1.283470e-02	1.892
Cargo trafficking to the periciliary membrane	R-HSA-5620920	1.283970e-02	1.891
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.323581e-02	1.878
Signaling by NOTCH2	R-HSA-1980145	1.323581e-02	1.878
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.323581e-02	1.878
TRAF6 mediated NF-kB activation	R-HSA-933542	1.390475e-02	1.857
Deadenylation of mRNA	R-HSA-429947	1.390475e-02	1.857
Metabolism of non-coding RNA	R-HSA-194441	1.431348e-02	1.844
snRNP Assembly	R-HSA-191859	1.431348e-02	1.844
KEAP1-NFE2L2 pathway	R-HSA-9755511	1.437606e-02	1.842
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	1.468619e-02	1.833
Regulation of BACH1 activity	R-HSA-9708530	1.487322e-02	1.828
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	1.519252e-02	1.818
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.519252e-02	1.818
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.524964e-02	1.817
Regulation of TP53 Expression	R-HSA-6804754	1.524964e-02	1.817
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.524964e-02	1.817
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.524964e-02	1.817
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.524964e-02	1.817
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.524964e-02	1.817
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.524964e-02	1.817
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.524964e-02	1.817
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.524964e-02	1.817
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.524964e-02	1.817
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.524964e-02	1.817
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.524964e-02	1.817
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.524964e-02	1.817
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.559552e-02	1.807
RET signaling	R-HSA-8853659	1.632559e-02	1.787
FLT3 signaling in disease	R-HSA-9682385	1.632559e-02	1.787
MAP kinase activation	R-HSA-450294	1.674534e-02	1.776
Intraflagellar transport	R-HSA-5620924	1.702156e-02	1.769
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.708962e-02	1.767
GRB2 events in ERBB2 signaling	R-HSA-1963640	1.744390e-02	1.758
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	1.744390e-02	1.758
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.744390e-02	1.758
Metalloprotease DUBs	R-HSA-5689901	1.782959e-02	1.749
UCH proteinases	R-HSA-5689603	1.829584e-02	1.738
Degradation of CDH1	R-HSA-9766229	1.853724e-02	1.732
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	1.853724e-02	1.732
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	1.906939e-02	1.720
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.914775e-02	1.718
Interferon alpha/beta signaling	R-HSA-909733	1.946791e-02	1.711
Translation of Structural Proteins	R-HSA-9694635	1.956276e-02	1.709
Signaling by Interleukins	R-HSA-449147	1.994653e-02	1.700
Interaction between L1 and Ankyrins	R-HSA-445095	2.004068e-02	1.698
Signaling by Hippo	R-HSA-2028269	2.027527e-02	1.693
Glycogen storage diseases	R-HSA-3229121	2.027527e-02	1.693
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.061077e-02	1.686
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	2.067914e-02	1.684
Signaling by NOTCH	R-HSA-157118	2.161418e-02	1.665
HSF1-dependent transactivation	R-HSA-3371571	2.184786e-02	1.661
Pyroptosis	R-HSA-5620971	2.242391e-02	1.649
Late SARS-CoV-2 Infection Events	R-HSA-9772573	2.289863e-02	1.640
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	2.311533e-02	1.636
FOXO-mediated transcription of cell death genes	R-HSA-9614657	2.337359e-02	1.631
Synaptic adhesion-like molecules	R-HSA-8849932	2.337359e-02	1.631
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.337359e-02	1.631
Platelet sensitization by LDL	R-HSA-432142	2.337359e-02	1.631
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	2.344238e-02	1.630
Receptor Mediated Mitophagy	R-HSA-8934903	2.344238e-02	1.630
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	2.344238e-02	1.630
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	2.364773e-02	1.626
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	2.374325e-02	1.624
Transcriptional regulation by RUNX1	R-HSA-8878171	2.382678e-02	1.623
Immune System	R-HSA-168256	2.409436e-02	1.618
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	3.229504e-02	1.491
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	3.229504e-02	1.491
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	3.229504e-02	1.491
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	3.229504e-02	1.491
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.831211e-02	1.548
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.831211e-02	1.548
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.831211e-02	1.548
Signaling by GSK3beta mutants	R-HSA-5339716	3.367569e-02	1.473
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	2.498354e-02	1.602
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	3.064685e-02	1.514
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.869077e-02	1.542
Transcription of the HIV genome	R-HSA-167172	2.759833e-02	1.559
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.614324e-02	1.583
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	3.431592e-02	1.465
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	3.039045e-02	1.517
SHC1 events in ERBB2 signaling	R-HSA-1250196	2.772339e-02	1.557
Specification of the neural plate border	R-HSA-9834899	2.674398e-02	1.573
Budding and maturation of HIV virion	R-HSA-162588	3.064685e-02	1.514
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	3.630802e-02	1.440
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.614324e-02	1.583
MTF1 activates gene expression	R-HSA-5660489	3.229504e-02	1.491
FLT3 signaling through SRC family kinases	R-HSA-9706374	3.229504e-02	1.491
Ionotropic activity of kainate receptors	R-HSA-451306	2.831211e-02	1.548
Signaling by APC mutants	R-HSA-4839744	2.831211e-02	1.548
Signaling by AMER1 mutants	R-HSA-4839748	3.367569e-02	1.473
Signaling by AXIN mutants	R-HSA-4839735	3.367569e-02	1.473
Estrogen-dependent gene expression	R-HSA-9018519	2.926797e-02	1.534
Smooth Muscle Contraction	R-HSA-445355	2.554710e-02	1.593
IKK complex recruitment mediated by RIP1	R-HSA-937041	2.674398e-02	1.573
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	3.375687e-02	1.472
Signaling by FGFR4	R-HSA-5654743	3.359505e-02	1.474
Signaling by FGFR1	R-HSA-5654736	3.186379e-02	1.497
EPHB-mediated forward signaling	R-HSA-3928662	3.635472e-02	1.439
Interleukin-17 signaling	R-HSA-448424	3.142937e-02	1.503
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	3.431592e-02	1.465
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	3.431592e-02	1.465
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.759833e-02	1.559
Response of Mtb to phagocytosis	R-HSA-9637690	3.359505e-02	1.474
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	3.186379e-02	1.497
Gene Silencing by RNA	R-HSA-211000	2.556737e-02	1.592
MHC class II antigen presentation	R-HSA-2132295	2.900835e-02	1.537
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.660987e-02	1.436
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.705593e-02	1.431
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	3.925567e-02	1.406
Signaling by FGFR3	R-HSA-5654741	3.925567e-02	1.406
RUNX3 regulates NOTCH signaling	R-HSA-8941856	3.952714e-02	1.403
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	3.952714e-02	1.403
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.952714e-02	1.403
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	3.952714e-02	1.403
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	3.952714e-02	1.403
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	3.952714e-02	1.403
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	3.952714e-02	1.403
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.014888e-02	1.396
Striated Muscle Contraction	R-HSA-390522	4.054610e-02	1.392
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.054610e-02	1.392
DNA Damage Recognition in GG-NER	R-HSA-5696394	4.054610e-02	1.392
Glucagon signaling in metabolic regulation	R-HSA-163359	4.054610e-02	1.392
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.120359e-02	1.385
PIP3 activates AKT signaling	R-HSA-1257604	4.131011e-02	1.384
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	4.265361e-02	1.370
Co-inhibition by BTLA	R-HSA-9927353	4.265361e-02	1.370
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	4.301038e-02	1.366
mTORC1-mediated signalling	R-HSA-166208	4.301038e-02	1.366
Dual Incision in GG-NER	R-HSA-5696400	4.422898e-02	1.354
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	4.422898e-02	1.354
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	4.422898e-02	1.354
NOD1/2 Signaling Pathway	R-HSA-168638	4.422898e-02	1.354
Calnexin/calreticulin cycle	R-HSA-901042	4.422898e-02	1.354
Opioid Signalling	R-HSA-111885	4.537282e-02	1.343
Response of endothelial cells to shear stress	R-HSA-9860931	4.537282e-02	1.343
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	4.539001e-02	1.343
Loss of Function of TP53 in Cancer	R-HSA-9723907	4.539001e-02	1.343
Leishmania infection	R-HSA-9658195	4.578724e-02	1.339
Parasitic Infection Pathways	R-HSA-9824443	4.578724e-02	1.339
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	4.585783e-02	1.339
Muscle contraction	R-HSA-397014	4.689537e-02	1.329
RSV-host interactions	R-HSA-9833110	4.756073e-02	1.323
Regulation of Apoptosis	R-HSA-169911	4.810573e-02	1.318
Gene expression (Transcription)	R-HSA-74160	4.942243e-02	1.306
Organelle biogenesis and maintenance	R-HSA-1852241	5.019909e-02	1.299
Eukaryotic Translation Elongation	R-HSA-156842	5.175328e-02	1.286
Vif-mediated degradation of APOBEC3G	R-HSA-180585	5.217707e-02	1.283
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	5.217707e-02	1.283
HSF1 activation	R-HSA-3371511	5.217707e-02	1.283
GPVI-mediated activation cascade	R-HSA-114604	5.217707e-02	1.283
Regulation of KIT signaling	R-HSA-1433559	5.265678e-02	1.279
Plasma lipoprotein assembly	R-HSA-8963898	5.283048e-02	1.277
Sensory processing of sound	R-HSA-9659379	5.313516e-02	1.275
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.355348e-02	1.271
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.406540e-02	1.267
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.406540e-02	1.267
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	5.406540e-02	1.267
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.406540e-02	1.267
Release of apoptotic factors from the mitochondria	R-HSA-111457	5.406540e-02	1.267
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	5.406540e-02	1.267
Regulation of CDH19 Expression and Function	R-HSA-9764302	5.406540e-02	1.267
TCF dependent signaling in response to WNT	R-HSA-201681	5.408178e-02	1.267
TRAF6 mediated IRF7 activation	R-HSA-933541	5.644331e-02	1.248
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	5.644331e-02	1.248
Degradation of DVL	R-HSA-4641258	5.644331e-02	1.248
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.644331e-02	1.248
Stimuli-sensing channels	R-HSA-2672351	5.701731e-02	1.244
Interleukin-1 family signaling	R-HSA-446652	5.795965e-02	1.237
Sema4D in semaphorin signaling	R-HSA-400685	5.815954e-02	1.235
Processing of DNA double-strand break ends	R-HSA-5693607	5.900398e-02	1.229
Activation of NF-kappaB in B cells	R-HSA-1169091	5.970661e-02	1.224
Beta-catenin phosphorylation cascade	R-HSA-196299	5.991104e-02	1.222
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.991104e-02	1.222
Ribosome-associated quality control	R-HSA-9948299	6.197560e-02	1.208
Innate Immune System	R-HSA-168249	6.272835e-02	1.203
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.360055e-02	1.197
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	6.363078e-02	1.196
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	6.376455e-02	1.195
Suppression of phagosomal maturation	R-HSA-9637687	6.376455e-02	1.195
C-type lectin receptors (CLRs)	R-HSA-5621481	6.425778e-02	1.192
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.552199e-02	1.184
Stabilization of p53	R-HSA-69541	6.555956e-02	1.183
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	6.555956e-02	1.183
Transcriptional Regulation by E2F6	R-HSA-8953750	6.555956e-02	1.183
RAS processing	R-HSA-9648002	6.555956e-02	1.183
Regulation of NFE2L2 gene expression	R-HSA-9818749	6.641374e-02	1.178
Nef and signal transduction	R-HSA-164944	6.641374e-02	1.178
Inositol phosphate metabolism	R-HSA-1483249	6.762919e-02	1.170
Meiotic synapsis	R-HSA-1221632	6.770320e-02	1.169
Transcriptional regulation by RUNX3	R-HSA-8878159	6.852799e-02	1.164
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	6.964198e-02	1.157
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	6.964198e-02	1.157
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	6.964198e-02	1.157
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	6.964198e-02	1.157
ER Quality Control Compartment (ERQC)	R-HSA-901032	6.964198e-02	1.157
Nuclear signaling by ERBB4	R-HSA-1251985	7.040810e-02	1.152
Regulation of RUNX3 expression and activity	R-HSA-8941858	7.040810e-02	1.152
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	7.040810e-02	1.152
Translation initiation complex formation	R-HSA-72649	7.192368e-02	1.143
Protein-protein interactions at synapses	R-HSA-6794362	7.192500e-02	1.143
Cellular responses to mechanical stimuli	R-HSA-9855142	7.337701e-02	1.134
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.471859e-02	1.127
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	7.544863e-02	1.122
Hh mutants are degraded by ERAD	R-HSA-5362768	7.544863e-02	1.122
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	7.544863e-02	1.122
SHC1 events in ERBB4 signaling	R-HSA-1250347	7.572525e-02	1.121
TRAF3-dependent IRF activation pathway	R-HSA-918233	7.572525e-02	1.121
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	7.572525e-02	1.121
HIV elongation arrest and recovery	R-HSA-167287	7.578757e-02	1.120
Pausing and recovery of HIV elongation	R-HSA-167290	7.578757e-02	1.120
Hedgehog 'on' state	R-HSA-5632684	7.866309e-02	1.104
Cohesin Loading onto Chromatin	R-HSA-2470946	7.959033e-02	1.099
Disinhibition of SNARE formation	R-HSA-114516	7.959033e-02	1.099
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	7.959033e-02	1.099
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	7.959033e-02	1.099
MECP2 regulates transcription factors	R-HSA-9022707	7.959033e-02	1.099
Uptake and function of diphtheria toxin	R-HSA-5336415	7.959033e-02	1.099
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.067943e-02	1.093
HIV Transcription Initiation	R-HSA-167161	8.067943e-02	1.093
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.067943e-02	1.093
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.080701e-02	1.093
Activation, translocation and oligomerization of BAX	R-HSA-114294	8.872240e-02	1.052
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	8.872240e-02	1.052
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	8.872240e-02	1.052
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	8.872240e-02	1.052
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	8.872240e-02	1.052
SARS-CoV-1 targets PDZ proteins in cell-cell junction	R-HSA-9692912	8.872240e-02	1.052
Defective Mismatch Repair Associated With MSH3	R-HSA-5632927	8.872240e-02	1.052
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	8.872240e-02	1.052
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	8.872240e-02	1.052
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	R-HSA-73930	1.300903e-01	0.886
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	1.300903e-01	0.886
Defective SLC12A3 causes Gitelman syndrome (GS)	R-HSA-5619087	1.300903e-01	0.886
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	1.300903e-01	0.886
Formation of annular gap junctions	R-HSA-196025	9.349478e-02	1.029
Signaling by MRAS-complex mutants	R-HSA-9660537	9.349478e-02	1.029
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	9.349478e-02	1.029
ARMS-mediated activation	R-HSA-170984	1.080341e-01	0.966
Gap junction degradation	R-HSA-190873	1.080341e-01	0.966
WNT mediated activation of DVL	R-HSA-201688	1.080341e-01	0.966
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	1.080341e-01	0.966
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.231221e-01	0.910
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.386792e-01	0.858
ERKs are inactivated	R-HSA-202670	1.546320e-01	0.811
PI3K events in ERBB4 signaling	R-HSA-1250342	1.546320e-01	0.811
Signaling by ERBB2 ECD mutants	R-HSA-9665348	9.316714e-02	1.031
Co-inhibition by CTLA4	R-HSA-389513	1.120876e-01	0.950
MyD88 deficiency (TLR2/4)	R-HSA-5602498	1.220529e-01	0.913
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	1.323277e-01	0.878
Notch-HLH transcription pathway	R-HSA-350054	1.428916e-01	0.845
RNA Polymerase II Promoter Escape	R-HSA-73776	9.170333e-02	1.038
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	1.034593e-01	0.985
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.034593e-01	0.985
Nucleosome assembly	R-HSA-774815	1.034593e-01	0.985
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.096040e-01	0.960
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.159218e-01	0.936
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	1.499630e-01	0.824
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.572297e-01	0.803
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.572297e-01	0.803
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	1.201899e-01	0.920
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.092233e-01	0.962
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	8.886283e-02	1.051
Mismatch Repair	R-HSA-5358508	9.316714e-02	1.031
EGFR Transactivation by Gastrin	R-HSA-2179392	1.231221e-01	0.910
GAB1 signalosome	R-HSA-180292	9.316714e-02	1.031
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	1.323277e-01	0.878
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	1.258269e-01	0.900
Regulation of CDH11 function	R-HSA-9762292	1.231221e-01	0.910
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	1.499630e-01	0.824
Neddylation	R-HSA-8951664	1.588686e-01	0.799
Cap-dependent Translation Initiation	R-HSA-72737	8.576644e-02	1.067
Eukaryotic Translation Initiation	R-HSA-72613	8.576644e-02	1.067
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	1.428427e-01	0.845
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	1.404847e-01	0.852
PI3K events in ERBB2 signaling	R-HSA-1963642	8.425176e-02	1.074
Deadenylation-dependent mRNA decay	R-HSA-429914	9.522518e-02	1.021
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.258269e-01	0.900
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	1.338931e-01	0.873
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	1.338931e-01	0.873
Fanconi Anemia Pathway	R-HSA-6783310	1.034593e-01	0.985
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.112428e-01	0.954
Rab regulation of trafficking	R-HSA-9007101	1.608390e-01	0.794
Cellular response to hypoxia	R-HSA-1234174	1.278524e-01	0.893
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.371156e-01	0.863
Adipogenesis	R-HSA-9843745	8.582570e-02	1.066
Interleukin-2 signaling	R-HSA-9020558	1.386792e-01	0.858
Neurexins and neuroligins	R-HSA-6794361	1.499630e-01	0.824
FCGR3A-mediated phagocytosis	R-HSA-9664422	1.195408e-01	0.922
Parasite infection	R-HSA-9664407	1.195408e-01	0.922
Leishmania phagocytosis	R-HSA-9664417	1.195408e-01	0.922
DNA Double-Strand Break Repair	R-HSA-5693532	1.067079e-01	0.972
Homology Directed Repair	R-HSA-5693538	9.240949e-02	1.034
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.170333e-02	1.038
TCR signaling	R-HSA-202403	1.195420e-01	0.922
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.290609e-01	0.889
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.290609e-01	0.889
Regulation of PTEN stability and activity	R-HSA-8948751	1.572297e-01	0.803
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.404847e-01	0.852
Formation of editosomes by ADAR proteins	R-HSA-77042	8.872240e-02	1.052
Inhibition of PKR	R-HSA-169131	8.872240e-02	1.052
Manipulation of host energy metabolism	R-HSA-9636667	1.300903e-01	0.886
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	1.300903e-01	0.886
Inactivation of CDC42 and RAC1	R-HSA-428543	1.080341e-01	0.966
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.546320e-01	0.811
DARPP-32 events	R-HSA-180024	8.219637e-02	1.085
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	1.034593e-01	0.985
Defective CFTR causes cystic fibrosis	R-HSA-5678895	1.034593e-01	0.985
Degradation of AXIN	R-HSA-4641257	1.506319e-01	0.822
GPER1 signaling	R-HSA-9634597	1.224088e-01	0.912
Generic Transcription Pathway	R-HSA-212436	1.237011e-01	0.908
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	1.516365e-01	0.819
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.586216e-01	0.800
Ephrin signaling	R-HSA-3928664	9.316714e-02	1.031
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.170333e-02	1.038
G1/S DNA Damage Checkpoints	R-HSA-69615	1.164327e-01	0.934
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.297473e-01	0.887
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.103194e-01	0.957
Cellular response to chemical stress	R-HSA-9711123	8.404090e-02	1.076
Transport to the Golgi and subsequent modification	R-HSA-948021	9.654391e-02	1.015
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	1.350632e-01	0.869
Regulation of T cell activation by CD28 family	R-HSA-388841	9.806281e-02	1.008
Vpu mediated degradation of CD4	R-HSA-180534	1.179744e-01	0.928
Diseases of DNA repair	R-HSA-9675135	1.096040e-01	0.960
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.055513e-01	0.977
NGF-stimulated transcription	R-HSA-9031628	1.224088e-01	0.912
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.295843e-01	0.887
Signaling by WNT	R-HSA-195721	1.625871e-01	0.789
G2/M Checkpoints	R-HSA-69481	1.300601e-01	0.886
Signaling by FGFR2	R-HSA-5654738	1.194390e-01	0.923
Co-stimulation by CD28	R-HSA-389356	1.224088e-01	0.912
Breakdown of the nuclear lamina	R-HSA-352238	1.300903e-01	0.886
SLC-mediated bile acid transport	R-HSA-9958517	9.349478e-02	1.029
GP1b-IX-V activation signalling	R-HSA-430116	1.080341e-01	0.966
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	1.231221e-01	0.910
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	1.034593e-01	0.985
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	8.272651e-02	1.082
PCP/CE pathway	R-HSA-4086400	1.095727e-01	0.960
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.342228e-01	0.872
Interleukin-1 signaling	R-HSA-9020702	8.140360e-02	1.089
Adaptive Immune System	R-HSA-1280218	1.539667e-01	0.813
Signaling by FGFR	R-HSA-190236	1.393456e-01	0.856
PECAM1 interactions	R-HSA-210990	1.386792e-01	0.858
PI3K/AKT Signaling in Cancer	R-HSA-2219528	9.240949e-02	1.034
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.034593e-01	0.985
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.034593e-01	0.985
Hedgehog ligand biogenesis	R-HSA-5358346	1.428427e-01	0.845
NTRK3 as a dependence receptor	R-HSA-9603505	1.300903e-01	0.886
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	1.231221e-01	0.910
Activation of RAC1	R-HSA-428540	1.546320e-01	0.811
G1 Phase	R-HSA-69236	9.749128e-02	1.011
Cyclin D associated events in G1	R-HSA-69231	9.749128e-02	1.011
Signaling by NTRKs	R-HSA-166520	9.109388e-02	1.041
Regulation of MECP2 expression and activity	R-HSA-9022692	1.103439e-01	0.957
Signaling by Leptin	R-HSA-2586552	1.231221e-01	0.910
MTOR signalling	R-HSA-165159	8.609847e-02	1.065
Infectious disease	R-HSA-5663205	1.194279e-01	0.923
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	9.349478e-02	1.029
Respiratory syncytial virus genome replication	R-HSA-9834752	1.080341e-01	0.966
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.272651e-02	1.082
SLC-mediated transport of inorganic anions	R-HSA-9958790	1.592865e-01	0.798
Ion channel transport	R-HSA-983712	1.107257e-01	0.956
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.586216e-01	0.800
Antigen processing-Cross presentation	R-HSA-1236975	1.112428e-01	0.954
Signaling by MET	R-HSA-6806834	1.194390e-01	0.923
Disorders of transmembrane transporters	R-HSA-5619115	1.227480e-01	0.911
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	1.200273e-01	0.921
Signaling by PDGFR in disease	R-HSA-9671555	1.323277e-01	0.878
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.506319e-01	0.822
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.278524e-01	0.893
SLC transporter disorders	R-HSA-5619102	1.581953e-01	0.801
Interleukin-37 signaling	R-HSA-9008059	8.886283e-02	1.051
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	1.068053e-01	0.971
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.646377e-01	0.783
Thromboxane signalling through TP receptor	R-HSA-428930	1.648042e-01	0.783
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	1.651325e-01	0.782
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.681189e-01	0.774
Plasma lipoprotein clearance	R-HSA-8964043	1.681189e-01	0.774
Peptide chain elongation	R-HSA-156902	1.691056e-01	0.772
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.695827e-01	0.771
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.695827e-01	0.771
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	1.695827e-01	0.771
Potassium transport channels	R-HSA-1296067	1.695827e-01	0.771
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	1.695827e-01	0.771
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	R-HSA-5619104	1.695827e-01	0.771
mRNA Editing: A to I Conversion	R-HSA-75064	1.695827e-01	0.771
C6 deamination of adenosine	R-HSA-75102	1.695827e-01	0.771
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	1.695827e-01	0.771
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.709126e-01	0.767
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.709126e-01	0.767
Disorders of Nervous System Development	R-HSA-9697154	1.709126e-01	0.767
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	1.709126e-01	0.767
Pervasive developmental disorders	R-HSA-9005895	1.709126e-01	0.767
Regulation of IFNG signaling	R-HSA-877312	1.709126e-01	0.767
OAS antiviral response	R-HSA-8983711	1.709126e-01	0.767
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.709126e-01	0.767
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.721118e-01	0.764
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.721818e-01	0.764
G alpha (z) signalling events	R-HSA-418597	1.721818e-01	0.764
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.729098e-01	0.762
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.749027e-01	0.757
ER-Phagosome pathway	R-HSA-1236974	1.751173e-01	0.757
RNA Polymerase II Transcription	R-HSA-73857	1.758635e-01	0.755
Polymerase switching on the C-strand of the telomere	R-HSA-174411	1.761120e-01	0.754
VEGFR2 mediated cell proliferation	R-HSA-5218921	1.761120e-01	0.754
Interleukin-7 signaling	R-HSA-1266695	1.761120e-01	0.754
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.771198e-01	0.752
HIV Transcription Elongation	R-HSA-167169	1.771198e-01	0.752
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.771198e-01	0.752
Attenuation phase	R-HSA-3371568	1.771198e-01	0.752
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.771198e-01	0.752
Diseases of Immune System	R-HSA-5260271	1.771198e-01	0.752
Diseases associated with the TLR signaling cascade	R-HSA-5602358	1.771198e-01	0.752
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.798565e-01	0.745
Ribosomal scanning and start codon recognition	R-HSA-72702	1.798565e-01	0.745
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.798565e-01	0.745
Nuclear events mediated by NFE2L2	R-HSA-9759194	1.811374e-01	0.742
Downstream TCR signaling	R-HSA-202424	1.812195e-01	0.742
Transcriptional Regulation by VENTX	R-HSA-8853884	1.862794e-01	0.730
Adenylate cyclase activating pathway	R-HSA-170660	1.874584e-01	0.727
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	1.874584e-01	0.727
Maturation of nucleoprotein	R-HSA-9683610	1.874584e-01	0.727
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	1.874584e-01	0.727
Protein ubiquitination	R-HSA-8852135	1.922570e-01	0.716
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	1.922570e-01	0.716
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.922570e-01	0.716
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.936850e-01	0.713
Hemostasis	R-HSA-109582	1.937949e-01	0.713
PTEN Regulation	R-HSA-6807070	1.944112e-01	0.711
Dual incision in TC-NER	R-HSA-6782135	1.955759e-01	0.709
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.955759e-01	0.709
Degradation of CRY and PER proteins	R-HSA-9932298	1.955883e-01	0.709
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.990825e-01	0.701
Interleukin-12 signaling	R-HSA-9020591	1.992904e-01	0.701
Packaging Of Telomere Ends	R-HSA-171306	1.993296e-01	0.700
Peroxisomal protein import	R-HSA-9033241	2.036092e-01	0.691
cGMP effects	R-HSA-418457	2.042120e-01	0.690
CRMPs in Sema3A signaling	R-HSA-399956	2.042120e-01	0.690
Signal regulatory protein family interactions	R-HSA-391160	2.042120e-01	0.690
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	2.050368e-01	0.688
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.072845e-01	0.683
Defective GCLC causes HAGGSD	R-HSA-5578999	2.072845e-01	0.683
MET activates PTPN11	R-HSA-8865999	2.072845e-01	0.683
Activation of BIM and translocation to mitochondria	R-HSA-111446	2.072845e-01	0.683
Activation of kainate receptors upon glutamate binding	R-HSA-451326	2.112002e-01	0.675
RAB geranylgeranylation	R-HSA-8873719	2.117506e-01	0.674
Regulation of PTEN gene transcription	R-HSA-8943724	2.117506e-01	0.674
TBC/RABGAPs	R-HSA-8854214	2.146153e-01	0.668
Signaling by SCF-KIT	R-HSA-1433557	2.146153e-01	0.668
Aquaporin-mediated transport	R-HSA-445717	2.199944e-01	0.658
ESR-mediated signaling	R-HSA-8939211	2.208937e-01	0.656
Adenylate cyclase inhibitory pathway	R-HSA-170670	2.211204e-01	0.655
Telomere C-strand synthesis initiation	R-HSA-174430	2.211204e-01	0.655
Lysosphingolipid and LPA receptors	R-HSA-419408	2.211204e-01	0.655
DCC mediated attractive signaling	R-HSA-418885	2.211204e-01	0.655
Protein methylation	R-HSA-8876725	2.211204e-01	0.655
Disease	R-HSA-1643685	2.225634e-01	0.653
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.232197e-01	0.651
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.232197e-01	0.651
Co-inhibition by PD-1	R-HSA-389948	2.238641e-01	0.650
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.243139e-01	0.649
Netrin-1 signaling	R-HSA-373752	2.243139e-01	0.649
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	2.283346e-01	0.641
Asymmetric localization of PCP proteins	R-HSA-4608870	2.341232e-01	0.631
Amyloid fiber formation	R-HSA-977225	2.357822e-01	0.627
rRNA modification in the nucleus and cytosol	R-HSA-6790901	2.367655e-01	0.626
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	2.381353e-01	0.623
Killing mechanisms	R-HSA-9664420	2.381353e-01	0.623
Prolonged ERK activation events	R-HSA-169893	2.381353e-01	0.623
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	2.381353e-01	0.623
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.381353e-01	0.623
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	2.432768e-01	0.614
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.432768e-01	0.614
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.432768e-01	0.614
Nucleotide catabolism defects	R-HSA-9735786	2.432768e-01	0.614
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	R-HSA-9735763	2.432768e-01	0.614
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.432768e-01	0.614
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.432768e-01	0.614
Regulation of gap junction activity	R-HSA-191650	2.432768e-01	0.614
TNFR1-mediated ceramide production	R-HSA-5626978	2.432768e-01	0.614
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	2.432768e-01	0.614
Transcriptional activation of p53 responsive genes	R-HSA-69560	2.432768e-01	0.614
Activation of NOXA and translocation to mitochondria	R-HSA-111448	2.432768e-01	0.614
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	2.440336e-01	0.613
Signaling by TGFBR3	R-HSA-9839373	2.440336e-01	0.613
Regulation of pyruvate metabolism	R-HSA-9861718	2.440336e-01	0.613
S Phase	R-HSA-69242	2.474129e-01	0.607
HATs acetylate histones	R-HSA-3214847	2.535559e-01	0.596
Circadian clock	R-HSA-9909396	2.540635e-01	0.595
Disorders of Developmental Biology	R-HSA-9675151	2.552122e-01	0.593
Acetylcholine regulates insulin secretion	R-HSA-399997	2.552122e-01	0.593
Synthesis of PG	R-HSA-1483148	2.552122e-01	0.593
Response to metal ions	R-HSA-5660526	2.552122e-01	0.593
Signaling by WNT in cancer	R-HSA-4791275	2.599882e-01	0.585
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.599882e-01	0.585
Metabolism of RNA	R-HSA-8953854	2.661606e-01	0.575
Meiosis	R-HSA-1500620	2.663280e-01	0.575
tRNA processing	R-HSA-72306	2.673428e-01	0.573
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.723104e-01	0.565
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.723104e-01	0.565
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	2.723104e-01	0.565
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	2.723104e-01	0.565
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	2.723104e-01	0.565
Specification of primordial germ cells	R-HSA-9827857	2.723104e-01	0.565
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	2.723104e-01	0.565
Integrin signaling	R-HSA-354192	2.724225e-01	0.565
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	2.724225e-01	0.565
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	2.741186e-01	0.562
Oxidative Stress Induced Senescence	R-HSA-2559580	2.746456e-01	0.561
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.776370e-01	0.557
IRS activation	R-HSA-74713	2.776370e-01	0.557
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.776370e-01	0.557
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.776370e-01	0.557
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	2.776370e-01	0.557
Defective SLC1A3 causes episodic ataxia 6 (EA6)	R-HSA-5619062	2.776370e-01	0.557
Activation of AKT2	R-HSA-165158	2.776370e-01	0.557
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	2.776370e-01	0.557
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	2.776370e-01	0.557
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.776370e-01	0.557
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.776370e-01	0.557
Regulation of PD-L1(CD274) expression	R-HSA-9909648	2.781723e-01	0.556
Transcriptional regulation by RUNX2	R-HSA-8878166	2.803818e-01	0.552
Integration of energy metabolism	R-HSA-163685	2.843956e-01	0.546
Beta-catenin independent WNT signaling	R-HSA-3858494	2.843956e-01	0.546
Regulation of RAS by GAPs	R-HSA-5658442	2.844980e-01	0.546
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	2.849180e-01	0.545
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	2.849180e-01	0.545
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	2.889504e-01	0.539
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	2.893928e-01	0.539
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	2.893928e-01	0.539
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.893928e-01	0.539
Vitamin D (calciferol) metabolism	R-HSA-196791	2.893928e-01	0.539
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.893928e-01	0.539
Apoptotic factor-mediated response	R-HSA-111471	2.893928e-01	0.539
Interleukin-12 family signaling	R-HSA-447115	2.898561e-01	0.538
MITF-M-regulated melanocyte development	R-HSA-9730414	2.911802e-01	0.536
Post-translational protein modification	R-HSA-597592	2.928846e-01	0.533
Chromosome Maintenance	R-HSA-73886	2.936386e-01	0.532
Platelet activation, signaling and aggregation	R-HSA-76002	2.959353e-01	0.529
Signal amplification	R-HSA-392518	2.974589e-01	0.527
Regulation of TLR by endogenous ligand	R-HSA-5686938	2.974589e-01	0.527
NPAS4 regulates expression of target genes	R-HSA-9768919	2.974589e-01	0.527
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	2.974589e-01	0.527
Diseases of programmed cell death	R-HSA-9645723	2.977950e-01	0.526
Cyclin E associated events during G1/S transition	R-HSA-69202	2.978229e-01	0.526
HCMV Late Events	R-HSA-9610379	2.988927e-01	0.524
Nucleotide Excision Repair	R-HSA-5696398	3.034230e-01	0.518
Formation of RNA Pol II elongation complex	R-HSA-112382	3.050959e-01	0.516
Orc1 removal from chromatin	R-HSA-68949	3.050959e-01	0.516
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.064258e-01	0.514
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.064258e-01	0.514
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.064258e-01	0.514
The NLRP3 inflammasome	R-HSA-844456	3.064258e-01	0.514
Maturation of nucleoprotein	R-HSA-9694631	3.064258e-01	0.514
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.067670e-01	0.513
Regulation of mitotic cell cycle	R-HSA-453276	3.067670e-01	0.513
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	3.104390e-01	0.508
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	3.104390e-01	0.508
IkBA variant leads to EDA-ID	R-HSA-5603029	3.104390e-01	0.508
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.104390e-01	0.508
Phase 1 - inactivation of fast Na+ channels	R-HSA-5576894	3.104390e-01	0.508
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	3.104390e-01	0.508
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	3.104390e-01	0.508
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	3.104390e-01	0.508
Synthesis of PS	R-HSA-1483101	3.104390e-01	0.508
Signalling to p38 via RIT and RIN	R-HSA-187706	3.104390e-01	0.508
CLEC7A/inflammasome pathway	R-HSA-5660668	3.104390e-01	0.508
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	3.104390e-01	0.508
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	3.104390e-01	0.508
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.104390e-01	0.508
Platelet homeostasis	R-HSA-418346	3.107145e-01	0.508
Base Excision Repair	R-HSA-73884	3.137925e-01	0.503
RNA Polymerase II Transcription Elongation	R-HSA-75955	3.154554e-01	0.501
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	3.157494e-01	0.501
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	3.180389e-01	0.498
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	3.218433e-01	0.492
Transcriptional Regulation by MECP2	R-HSA-8986944	3.218433e-01	0.492
Triglyceride catabolism	R-HSA-163560	3.226165e-01	0.491
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.233787e-01	0.490
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.233787e-01	0.490
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.233787e-01	0.490
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.233787e-01	0.490
Nephrin family interactions	R-HSA-373753	3.233787e-01	0.490
Signal transduction by L1	R-HSA-445144	3.233787e-01	0.490
Switching of origins to a post-replicative state	R-HSA-69052	3.247645e-01	0.488
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.273819e-01	0.485
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.273819e-01	0.485
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.273819e-01	0.485
Class I MHC mediated antigen processing & presentation	R-HSA-983169	3.313687e-01	0.480
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	3.325127e-01	0.478
DNA Replication Pre-Initiation	R-HSA-69002	3.327742e-01	0.478
G2/M DNA damage checkpoint	R-HSA-69473	3.338067e-01	0.477
Voltage gated Potassium channels	R-HSA-1296072	3.352047e-01	0.475
Cleavage of the damaged purine	R-HSA-110331	3.352047e-01	0.475
ERK/MAPK targets	R-HSA-198753	3.402236e-01	0.468
Zygotic genome activation (ZGA)	R-HSA-9819196	3.402236e-01	0.468
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.417534e-01	0.466
STAT5 Activation	R-HSA-9645135	3.417534e-01	0.466
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	3.417534e-01	0.466
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.417534e-01	0.466
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.417534e-01	0.466
Assembly of the pre-replicative complex	R-HSA-68867	3.461556e-01	0.461
Ion homeostasis	R-HSA-5578775	3.466759e-01	0.460
Intrinsic Pathway for Apoptosis	R-HSA-109606	3.466759e-01	0.460
Depurination	R-HSA-73927	3.477812e-01	0.459
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.550484e-01	0.450
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.550484e-01	0.450
Signaling by NTRK3 (TRKC)	R-HSA-9034015	3.569355e-01	0.447
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.569355e-01	0.447
Mitochondrial calcium ion transport	R-HSA-8949215	3.569355e-01	0.447
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.571034e-01	0.447
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.603332e-01	0.443
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	3.603332e-01	0.443
Reproduction	R-HSA-1474165	3.686685e-01	0.433
ABC transporter disorders	R-HSA-5619084	3.701408e-01	0.432
Formation of a pool of free 40S subunits	R-HSA-72689	3.706270e-01	0.431
Eukaryotic Translation Termination	R-HSA-72764	3.706270e-01	0.431
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.716475e-01	0.430
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	3.716475e-01	0.430
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.716475e-01	0.430
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.716475e-01	0.430
IFNG signaling activates MAPKs	R-HSA-9732724	3.716475e-01	0.430
SOS-mediated signalling	R-HSA-112412	3.716475e-01	0.430
RUNX3 regulates WNT signaling	R-HSA-8951430	3.716475e-01	0.430
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.716475e-01	0.430
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.716475e-01	0.430
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.716475e-01	0.430
Netrin mediated repulsion signals	R-HSA-418886	3.716475e-01	0.430
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.728487e-01	0.428
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	3.728487e-01	0.428
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	3.728487e-01	0.428
Interleukin-2 family signaling	R-HSA-451927	3.728487e-01	0.428
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	3.734917e-01	0.428
Regulation of IFNA/IFNB signaling	R-HSA-912694	3.734917e-01	0.428
Triglyceride metabolism	R-HSA-8979227	3.779438e-01	0.423
Resolution of Abasic Sites (AP sites)	R-HSA-73933	3.853162e-01	0.414
Maturation of spike protein	R-HSA-9694548	3.853162e-01	0.414
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.869797e-01	0.412
Interleukin receptor SHC signaling	R-HSA-912526	3.898720e-01	0.409
Carnitine shuttle	R-HSA-200425	3.898720e-01	0.409
Syndecan interactions	R-HSA-3000170	3.898720e-01	0.409
Growth hormone receptor signaling	R-HSA-982772	3.898720e-01	0.409
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	3.898720e-01	0.409
rRNA processing	R-HSA-72312	3.901430e-01	0.409
Regulation of insulin secretion	R-HSA-422356	3.951567e-01	0.403
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	3.977248e-01	0.400
DNA Replication	R-HSA-69306	3.994692e-01	0.399
Type I hemidesmosome assembly	R-HSA-446107	4.001858e-01	0.398
EGFR interacts with phospholipase C-gamma	R-HSA-212718	4.001858e-01	0.398
Regulation by c-FLIP	R-HSA-3371378	4.001858e-01	0.398
FGFR1b ligand binding and activation	R-HSA-190370	4.001858e-01	0.398
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	4.001858e-01	0.398
Dimerization of procaspase-8	R-HSA-69416	4.001858e-01	0.398
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	4.001858e-01	0.398
Adrenoceptors	R-HSA-390696	4.001858e-01	0.398
RSK activation	R-HSA-444257	4.001858e-01	0.398
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.001858e-01	0.398
FOXO-mediated transcription	R-HSA-9614085	4.033294e-01	0.394
Asparagine N-linked glycosylation	R-HSA-446203	4.052372e-01	0.392
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.059872e-01	0.391
Cleavage of the damaged pyrimidine	R-HSA-110329	4.100642e-01	0.387
Depyrimidination	R-HSA-73928	4.100642e-01	0.387
Selenocysteine synthesis	R-HSA-2408557	4.196485e-01	0.377
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.220341e-01	0.375
Tight junction interactions	R-HSA-420029	4.220341e-01	0.375
TGFBR3 expression	R-HSA-9839394	4.220341e-01	0.375
Glycogen breakdown (glycogenolysis)	R-HSA-70221	4.220341e-01	0.375
Formation of the nephric duct	R-HSA-9830364	4.220341e-01	0.375
Defective pyroptosis	R-HSA-9710421	4.223249e-01	0.374
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	4.274295e-01	0.369
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	4.274295e-01	0.369
CASP8 activity is inhibited	R-HSA-5218900	4.274295e-01	0.369
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.274295e-01	0.369
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.274295e-01	0.369
mRNA Editing	R-HSA-75072	4.274295e-01	0.369
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.274295e-01	0.369
MAPK1 (ERK2) activation	R-HSA-112411	4.274295e-01	0.369
Regulation of CDH11 gene transcription	R-HSA-9762293	4.274295e-01	0.369
AKT phosphorylates targets in the nucleus	R-HSA-198693	4.274295e-01	0.369
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	4.274295e-01	0.369
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.274295e-01	0.369
Regulated proteolysis of p75NTR	R-HSA-193692	4.274295e-01	0.369
Interleukin-1 processing	R-HSA-448706	4.274295e-01	0.369
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	4.274295e-01	0.369
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.274295e-01	0.369
Ion transport by P-type ATPases	R-HSA-936837	4.296346e-01	0.367
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.320498e-01	0.364
Translation	R-HSA-72766	4.337723e-01	0.363
Viral mRNA Translation	R-HSA-192823	4.359104e-01	0.361
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	4.377856e-01	0.359
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.377856e-01	0.359
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	4.377856e-01	0.359
Myogenesis	R-HSA-525793	4.377856e-01	0.359
TRP channels	R-HSA-3295583	4.377856e-01	0.359
Interferon gamma signaling	R-HSA-877300	4.385544e-01	0.358
Signaling by TGFB family members	R-HSA-9006936	4.450512e-01	0.352
Platelet Aggregation (Plug Formation)	R-HSA-76009	4.465742e-01	0.350
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.465742e-01	0.350
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	4.500138e-01	0.347
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	4.521679e-01	0.345
Processive synthesis on the C-strand of the telomere	R-HSA-174414	4.533000e-01	0.344
CD28 dependent PI3K/Akt signaling	R-HSA-389357	4.533000e-01	0.344
EPHA-mediated growth cone collapse	R-HSA-3928663	4.533000e-01	0.344
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.533000e-01	0.344
PI3K/AKT activation	R-HSA-198203	4.534374e-01	0.343
Signal attenuation	R-HSA-74749	4.534374e-01	0.343
MET activates RAP1 and RAC1	R-HSA-8875555	4.534374e-01	0.343
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.534374e-01	0.343
Maturation of spike protein	R-HSA-9683686	4.534374e-01	0.343
MAPK3 (ERK1) activation	R-HSA-110056	4.534374e-01	0.343
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.534374e-01	0.343
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	4.534374e-01	0.343
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	4.585462e-01	0.339
Pyruvate metabolism	R-HSA-70268	4.604145e-01	0.337
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.685665e-01	0.329
Formation of the Early Elongation Complex	R-HSA-113418	4.685665e-01	0.329
Telomere Extension By Telomerase	R-HSA-171319	4.685665e-01	0.329
Phase 0 - rapid depolarisation	R-HSA-5576892	4.685665e-01	0.329
Inflammasomes	R-HSA-622312	4.685665e-01	0.329
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.704065e-01	0.328
Synthesis of PC	R-HSA-1483191	4.704065e-01	0.328
Synthesis of DNA	R-HSA-69239	4.761516e-01	0.322
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.782655e-01	0.320
vRNP Assembly	R-HSA-192905	4.782655e-01	0.320
Bicarbonate transporters	R-HSA-425381	4.782655e-01	0.320
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.782655e-01	0.320
Transport of RCbl within the body	R-HSA-9758890	4.782655e-01	0.320
Synthesis of PIPs at the ER membrane	R-HSA-1483248	4.782655e-01	0.320
LGI-ADAM interactions	R-HSA-5682910	4.782655e-01	0.320
SARS-CoV-2 modulates autophagy	R-HSA-9754560	4.782655e-01	0.320
Suppression of apoptosis	R-HSA-9635465	4.782655e-01	0.320
Prostanoid ligand receptors	R-HSA-391908	4.782655e-01	0.320
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	4.816491e-01	0.317
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	4.821481e-01	0.317
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.821481e-01	0.317
Impaired BRCA2 binding to RAD51	R-HSA-9709570	4.835755e-01	0.316
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	4.835755e-01	0.316
Regulation of CDH1 Gene Transcription	R-HSA-9764560	4.900186e-01	0.310
DAP12 signaling	R-HSA-2424491	4.983189e-01	0.302
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.983189e-01	0.302
Activation of BH3-only proteins	R-HSA-114452	4.983189e-01	0.302
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	4.983189e-01	0.302
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	4.998348e-01	0.301
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	5.019672e-01	0.299
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	5.019672e-01	0.299
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	5.019672e-01	0.299
Plasmalogen biosynthesis	R-HSA-75896	5.019672e-01	0.299
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.019672e-01	0.299
Reduction of cytosolic Ca++ levels	R-HSA-418359	5.019672e-01	0.299
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.019672e-01	0.299
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.019672e-01	0.299
PI3K Cascade	R-HSA-109704	5.052502e-01	0.296
Negative regulation of the PI3K/AKT network	R-HSA-199418	5.106783e-01	0.292
Cargo concentration in the ER	R-HSA-5694530	5.127900e-01	0.290
Chromatin modifying enzymes	R-HSA-3247509	5.159182e-01	0.287
Diseases of carbohydrate metabolism	R-HSA-5663084	5.192155e-01	0.285
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.245935e-01	0.280
RUNX3 regulates p14-ARF	R-HSA-8951936	5.245935e-01	0.280
Scavenging by Class F Receptors	R-HSA-3000484	5.245935e-01	0.280
Polymerase switching	R-HSA-69091	5.245935e-01	0.280
Leading Strand Synthesis	R-HSA-69109	5.245935e-01	0.280
GRB2 events in EGFR signaling	R-HSA-179812	5.245935e-01	0.280
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.245935e-01	0.280
Signaling by LTK	R-HSA-9842663	5.245935e-01	0.280
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.245935e-01	0.280
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.245935e-01	0.280
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	5.245935e-01	0.280
Transcriptional Regulation by NPAS4	R-HSA-9634815	5.278071e-01	0.278
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	5.298391e-01	0.276
Iron uptake and transport	R-HSA-917937	5.382354e-01	0.269
Golgi Associated Vesicle Biogenesis	R-HSA-432722	5.388690e-01	0.269
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	5.388690e-01	0.269
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	5.391187e-01	0.268
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	5.408933e-01	0.267
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	5.408933e-01	0.267
Nuclear RNA decay	R-HSA-9930044	5.408933e-01	0.267
FGFR1 mutant receptor activation	R-HSA-1839124	5.408933e-01	0.267
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	5.408933e-01	0.267
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.461932e-01	0.263
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	5.461932e-01	0.263
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	5.461932e-01	0.263
Frs2-mediated activation	R-HSA-170968	5.461932e-01	0.263
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	5.461932e-01	0.263
Diseases of nucleotide metabolism	R-HSA-9735804	5.461932e-01	0.263
FGFR1c ligand binding and activation	R-HSA-190373	5.461932e-01	0.263
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.461932e-01	0.263
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.461932e-01	0.263
CD28 dependent Vav1 pathway	R-HSA-389359	5.461932e-01	0.263
Interleukin-6 signaling	R-HSA-1059683	5.461932e-01	0.263
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	5.497810e-01	0.260
Base-Excision Repair, AP Site Formation	R-HSA-73929	5.497810e-01	0.260
Developmental Cell Lineages	R-HSA-9734767	5.539169e-01	0.257
Resolution of D-Loop Structures	R-HSA-5693537	5.545174e-01	0.256
Miscellaneous transport and binding events	R-HSA-5223345	5.545174e-01	0.256
HDACs deacetylate histones	R-HSA-3214815	5.605392e-01	0.251
Nuclear Receptor transcription pathway	R-HSA-383280	5.660313e-01	0.247
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.668127e-01	0.247
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	5.668127e-01	0.247
Formation of the active cofactor, UDP-glucuronate	R-HSA-173599	5.668127e-01	0.247
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.668127e-01	0.247
Prolactin receptor signaling	R-HSA-1170546	5.668127e-01	0.247
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	5.678525e-01	0.246
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	5.678525e-01	0.246
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	5.678525e-01	0.246
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	5.678525e-01	0.246
Signalling to ERKs	R-HSA-187687	5.808968e-01	0.236
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.808968e-01	0.236
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.808968e-01	0.236
IRS-mediated signalling	R-HSA-112399	5.815818e-01	0.235
SHC1 events in EGFR signaling	R-HSA-180336	5.864966e-01	0.232
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.864966e-01	0.232
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	5.864966e-01	0.232
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	5.864966e-01	0.232
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.864966e-01	0.232
ABC-family proteins mediated transport	R-HSA-382556	5.871287e-01	0.231
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.928800e-01	0.227
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	5.936491e-01	0.226
RNA Polymerase III Transcription	R-HSA-74158	5.936491e-01	0.226
Chromatin organization	R-HSA-4839726	5.951015e-01	0.225
Infection with Mycobacterium tuberculosis	R-HSA-9635486	5.976106e-01	0.224
Extension of Telomeres	R-HSA-180786	6.019750e-01	0.220
Regulation of beta-cell development	R-HSA-186712	6.019750e-01	0.220
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.052872e-01	0.218
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	6.052872e-01	0.218
Phosphorylation of the APC/C	R-HSA-176412	6.052872e-01	0.218
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	6.052872e-01	0.218
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	6.052872e-01	0.218
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.052872e-01	0.218
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	6.052872e-01	0.218
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.052872e-01	0.218
Induction of Cell-Cell Fusion	R-HSA-9733458	6.052872e-01	0.218
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	6.052872e-01	0.218
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.052872e-01	0.218
Differentiation of T cells	R-HSA-9945266	6.052872e-01	0.218
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.052872e-01	0.218
Activation of SMO	R-HSA-5635838	6.052872e-01	0.218
Attachment and Entry	R-HSA-9678110	6.052872e-01	0.218
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	6.119227e-01	0.213
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.182770e-01	0.209
Formation of the cornified envelope	R-HSA-6809371	6.186769e-01	0.209
IRS-related events triggered by IGF1R	R-HSA-2428928	6.217022e-01	0.206
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.232250e-01	0.205
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	6.232250e-01	0.205
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	6.232250e-01	0.205
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	6.232250e-01	0.205
Biosynthesis of maresin-like SPMs	R-HSA-9027307	6.232250e-01	0.205
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	6.232250e-01	0.205
Galactose catabolism	R-HSA-70370	6.232250e-01	0.205
Signaling by ALK	R-HSA-201556	6.301535e-01	0.201
Heme signaling	R-HSA-9707616	6.313123e-01	0.200
G1/S Transition	R-HSA-69206	6.323689e-01	0.199
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	6.403486e-01	0.194
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.403486e-01	0.194
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	6.403486e-01	0.194
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	6.417401e-01	0.193
Generation of second messenger molecules	R-HSA-202433	6.417401e-01	0.193
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	6.435119e-01	0.191
XBP1(S) activates chaperone genes	R-HSA-381038	6.435119e-01	0.191
Insulin receptor signalling cascade	R-HSA-74751	6.500205e-01	0.187
IGF1R signaling cascade	R-HSA-2428924	6.500205e-01	0.187
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	6.530386e-01	0.185
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.530386e-01	0.185
mRNA Splicing - Major Pathway	R-HSA-72163	6.565768e-01	0.183
Polo-like kinase mediated events	R-HSA-156711	6.566950e-01	0.183
RNA Polymerase III Transcription Termination	R-HSA-73980	6.566950e-01	0.183
FGFR1 ligand binding and activation	R-HSA-190242	6.566950e-01	0.183
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.566950e-01	0.183
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.566950e-01	0.183
Tie2 Signaling	R-HSA-210993	6.566950e-01	0.183
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	6.591173e-01	0.181
MITF-M-dependent gene expression	R-HSA-9856651	6.632870e-01	0.178
Signaling by FGFR1 in disease	R-HSA-5655302	6.640512e-01	0.178
Intra-Golgi traffic	R-HSA-6811438	6.640512e-01	0.178
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	6.678552e-01	0.175
Leishmania parasite growth and survival	R-HSA-9664433	6.678552e-01	0.175
G alpha (q) signalling events	R-HSA-416476	6.679568e-01	0.175
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.722994e-01	0.172
PI-3K cascade:FGFR3	R-HSA-5654710	6.722994e-01	0.172
O2/CO2 exchange in erythrocytes	R-HSA-1480926	6.722994e-01	0.172
Pre-NOTCH Processing in Golgi	R-HSA-1912420	6.722994e-01	0.172
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	6.722994e-01	0.172
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	6.722994e-01	0.172
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.747805e-01	0.171
Activation of GABAB receptors	R-HSA-991365	6.747805e-01	0.171
GABA B receptor activation	R-HSA-977444	6.747805e-01	0.171
Protein localization	R-HSA-9609507	6.809142e-01	0.167
Pre-NOTCH Transcription and Translation	R-HSA-1912408	6.824124e-01	0.166
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	6.853767e-01	0.164
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	6.871954e-01	0.163
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	6.871954e-01	0.163
VxPx cargo-targeting to cilium	R-HSA-5620916	6.871954e-01	0.163
PI-3K cascade:FGFR4	R-HSA-5654720	6.871954e-01	0.163
Wax and plasmalogen biosynthesis	R-HSA-8848584	6.871954e-01	0.163
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	6.871954e-01	0.163
Common Pathway of Fibrin Clot Formation	R-HSA-140875	6.871954e-01	0.163
Eicosanoid ligand-binding receptors	R-HSA-391903	6.871954e-01	0.163
Pre-NOTCH Expression and Processing	R-HSA-1912422	6.891932e-01	0.162
IRE1alpha activates chaperones	R-HSA-381070	6.898243e-01	0.161
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.902803e-01	0.161
DAP12 interactions	R-HSA-2172127	6.954016e-01	0.158
Signaling by Nuclear Receptors	R-HSA-9006931	6.993538e-01	0.155
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.014152e-01	0.154
Lagging Strand Synthesis	R-HSA-69186	7.014152e-01	0.154
COPII-mediated vesicle transport	R-HSA-204005	7.020260e-01	0.154
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	7.028993e-01	0.153
Cellular response to starvation	R-HSA-9711097	7.089684e-01	0.149
NoRC negatively regulates rRNA expression	R-HSA-427413	7.100952e-01	0.149
mRNA Splicing	R-HSA-72172	7.126338e-01	0.147
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.149294e-01	0.146
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.149294e-01	0.146
FRS-mediated FGFR3 signaling	R-HSA-5654706	7.149894e-01	0.146
Glutathione synthesis and recycling	R-HSA-174403	7.149894e-01	0.146
Attachment and Entry	R-HSA-9694614	7.149894e-01	0.146
Ribavirin ADME	R-HSA-9755088	7.149894e-01	0.146
trans-Golgi Network Vesicle Budding	R-HSA-199992	7.179954e-01	0.144
Epigenetic regulation of gene expression	R-HSA-212165	7.225806e-01	0.141
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.242930e-01	0.140
Ca2+ pathway	R-HSA-4086398	7.257276e-01	0.139
Mitochondrial biogenesis	R-HSA-1592230	7.272773e-01	0.138
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.279472e-01	0.138
FGFR2 alternative splicing	R-HSA-6803529	7.279472e-01	0.138
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.279472e-01	0.138
PI-3K cascade:FGFR1	R-HSA-5654689	7.279472e-01	0.138
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.279472e-01	0.138
FRS-mediated FGFR4 signaling	R-HSA-5654712	7.279472e-01	0.138
RAF-independent MAPK1/3 activation	R-HSA-112409	7.279472e-01	0.138
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.279472e-01	0.138
Potassium Channels	R-HSA-1296071	7.317064e-01	0.136
Signaling by FGFR in disease	R-HSA-1226099	7.332931e-01	0.135
Gluconeogenesis	R-HSA-70263	7.333953e-01	0.135
Telomere Maintenance	R-HSA-157579	7.382571e-01	0.132
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.403167e-01	0.131
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.403167e-01	0.131
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.403167e-01	0.131
Biosynthesis of maresins	R-HSA-9018682	7.403167e-01	0.131
Formation of the ureteric bud	R-HSA-9830674	7.403167e-01	0.131
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	7.403167e-01	0.131
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	7.403167e-01	0.131
Interleukin-20 family signaling	R-HSA-8854691	7.403167e-01	0.131
Selenoamino acid metabolism	R-HSA-2408522	7.404011e-01	0.131
Post-translational protein phosphorylation	R-HSA-8957275	7.446863e-01	0.128
CYP2E1 reactions	R-HSA-211999	7.521245e-01	0.124
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	7.521245e-01	0.124
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	7.521245e-01	0.124
Interleukin-6 family signaling	R-HSA-6783589	7.521245e-01	0.124
TNFs bind their physiological receptors	R-HSA-5669034	7.521245e-01	0.124
Neurodegenerative Diseases	R-HSA-8863678	7.521245e-01	0.124
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	7.521245e-01	0.124
Meiotic recombination	R-HSA-912446	7.591791e-01	0.120
FCERI mediated NF-kB activation	R-HSA-2871837	7.626769e-01	0.118
PI-3K cascade:FGFR2	R-HSA-5654695	7.633961e-01	0.117
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.633961e-01	0.117
ATP-dependent chromatin remodelers	R-HSA-9932444	7.633961e-01	0.117
SWI/SNF chromatin remodelers	R-HSA-9932451	7.633961e-01	0.117
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.633961e-01	0.117
Acyl chain remodelling of PS	R-HSA-1482801	7.633961e-01	0.117
HDMs demethylate histones	R-HSA-3214842	7.633961e-01	0.117
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.633961e-01	0.117
mRNA 3'-end processing	R-HSA-72187	7.672814e-01	0.115
Uptake and actions of bacterial toxins	R-HSA-5339562	7.672814e-01	0.115
Mitotic G1 phase and G1/S transition	R-HSA-453279	7.726199e-01	0.112
Signaling by FLT3 fusion proteins	R-HSA-9703465	7.741558e-01	0.111
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	7.741558e-01	0.111
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	7.741558e-01	0.111
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.741558e-01	0.111
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.741558e-01	0.111
Sphingolipid catabolism	R-HSA-9845614	7.741558e-01	0.111
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	7.741558e-01	0.111
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.752666e-01	0.111
RNA Polymerase I Transcription Termination	R-HSA-73863	7.844268e-01	0.105
Cristae formation	R-HSA-8949613	7.844268e-01	0.105
RNA Polymerase I Promoter Opening	R-HSA-73728	7.844268e-01	0.105
Triglyceride biosynthesis	R-HSA-75109	7.844268e-01	0.105
Signaling by NTRK2 (TRKB)	R-HSA-9006115	7.844268e-01	0.105
Maturation of hRSV A proteins	R-HSA-9828806	7.844268e-01	0.105
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	7.863480e-01	0.104
Activation of HOX genes during differentiation	R-HSA-5619507	7.863480e-01	0.104
Gastrulation	R-HSA-9758941	7.869460e-01	0.104
Potential therapeutics for SARS	R-HSA-9679191	7.915660e-01	0.102
Cytoprotection by HMOX1	R-HSA-9707564	7.941352e-01	0.100
FRS-mediated FGFR2 signaling	R-HSA-5654700	7.942313e-01	0.100
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	7.942313e-01	0.100
Detoxification of Reactive Oxygen Species	R-HSA-3299685	7.973586e-01	0.098
DNA methylation	R-HSA-5334118	8.035905e-01	0.095
mRNA Capping	R-HSA-72086	8.035905e-01	0.095
Thyroxine biosynthesis	R-HSA-209968	8.035905e-01	0.095
Downstream signaling of activated FGFR3	R-HSA-5654708	8.035905e-01	0.095
Regulation of gene expression in beta cells	R-HSA-210745	8.035905e-01	0.095
Platelet calcium homeostasis	R-HSA-418360	8.035905e-01	0.095
Synthesis of PA	R-HSA-1483166	8.043196e-01	0.095
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.110672e-01	0.091
Cardiac conduction	R-HSA-5576891	8.120307e-01	0.090
Activation of the pre-replicative complex	R-HSA-68962	8.125245e-01	0.090
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	8.125245e-01	0.090
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.125245e-01	0.090
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.125245e-01	0.090
Downstream signaling of activated FGFR4	R-HSA-5654716	8.125245e-01	0.090
PPARA activates gene expression	R-HSA-1989781	8.135212e-01	0.090
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.210526e-01	0.086
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	8.210526e-01	0.086
Downstream signal transduction	R-HSA-186763	8.210526e-01	0.086
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.217793e-01	0.085
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	8.239424e-01	0.084
GABA receptor activation	R-HSA-977443	8.239424e-01	0.084
G0 and Early G1	R-HSA-1538133	8.291933e-01	0.081
DNA strand elongation	R-HSA-69190	8.291933e-01	0.081
Diseases of mitotic cell cycle	R-HSA-9675126	8.291933e-01	0.081
Inwardly rectifying K+ channels	R-HSA-1296065	8.291933e-01	0.081
RNA Polymerase II Transcription Termination	R-HSA-73856	8.300799e-01	0.081
Formation of paraxial mesoderm	R-HSA-9793380	8.300799e-01	0.081
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.360239e-01	0.078
Mitochondrial protein import	R-HSA-1268020	8.360239e-01	0.078
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	8.369642e-01	0.077
Activation of ATR in response to replication stress	R-HSA-176187	8.369642e-01	0.077
Assembly of the ORC complex at the origin of replication	R-HSA-68616	8.369642e-01	0.077
Cardiogenesis	R-HSA-9733709	8.369642e-01	0.077
G-protein beta:gamma signalling	R-HSA-397795	8.369642e-01	0.077
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	8.369642e-01	0.077
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	8.406541e-01	0.075
Effects of PIP2 hydrolysis	R-HSA-114508	8.443819e-01	0.073
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.443819e-01	0.073
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.443819e-01	0.073
Heme degradation	R-HSA-189483	8.443819e-01	0.073
Unfolded Protein Response (UPR)	R-HSA-381119	8.496112e-01	0.071
eNOS activation	R-HSA-203615	8.514626e-01	0.070
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.514626e-01	0.070
Signaling by Insulin receptor	R-HSA-74752	8.523292e-01	0.069
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	8.568333e-01	0.067
Downstream signaling of activated FGFR2	R-HSA-5654696	8.582215e-01	0.066
Downstream signaling of activated FGFR1	R-HSA-5654687	8.582215e-01	0.066
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	8.582215e-01	0.066
PERK regulates gene expression	R-HSA-381042	8.582215e-01	0.066
Kidney development	R-HSA-9830369	8.630112e-01	0.064
PRC2 methylates histones and DNA	R-HSA-212300	8.646733e-01	0.063
Lysosome Vesicle Biogenesis	R-HSA-432720	8.646733e-01	0.063
G1/S-Specific Transcription	R-HSA-69205	8.646733e-01	0.063
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.646733e-01	0.063
FGFR2 mutant receptor activation	R-HSA-1839126	8.646733e-01	0.063
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.708318e-01	0.060
SLC-mediated transport of organic cations	R-HSA-549127	8.708318e-01	0.060
Metabolism of folate and pterines	R-HSA-196757	8.708318e-01	0.060
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	8.767105e-01	0.057
MET promotes cell motility	R-HSA-8875878	8.767105e-01	0.057
Purine salvage	R-HSA-74217	8.767105e-01	0.057
Metabolism of proteins	R-HSA-392499	8.783161e-01	0.056
Metabolism of cofactors	R-HSA-8978934	8.816030e-01	0.055
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.823219e-01	0.054
Glycerophospholipid biosynthesis	R-HSA-1483206	8.899981e-01	0.051
Extracellular matrix organization	R-HSA-1474244	8.900119e-01	0.051
Extra-nuclear estrogen signaling	R-HSA-9009391	8.922308e-01	0.050
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	8.927911e-01	0.049
PKMTs methylate histone lysines	R-HSA-3214841	8.927911e-01	0.049
ROS and RNS production in phagocytes	R-HSA-1222556	8.939856e-01	0.049
Platelet degranulation	R-HSA-114608	8.956280e-01	0.048
Regulation of endogenous retroelements	R-HSA-9842860	8.956363e-01	0.048
PI Metabolism	R-HSA-1483255	8.956363e-01	0.048
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.976716e-01	0.047
GPCR downstream signalling	R-HSA-388396	8.981237e-01	0.047
RNA Polymerase I Promoter Clearance	R-HSA-73854	9.015602e-01	0.045
Cytosolic tRNA aminoacylation	R-HSA-379716	9.023301e-01	0.045
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.023301e-01	0.045
RNA Polymerase I Transcription	R-HSA-73864	9.086274e-01	0.042
SLC-mediated transport of organic anions	R-HSA-9955298	9.086274e-01	0.042
Surfactant metabolism	R-HSA-5683826	9.110214e-01	0.040
Amine ligand-binding receptors	R-HSA-375280	9.110214e-01	0.040
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.110214e-01	0.040
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.119803e-01	0.040
mRNA Splicing - Minor Pathway	R-HSA-72165	9.189402e-01	0.037
Condensation of Prophase Chromosomes	R-HSA-2299718	9.189402e-01	0.037
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.189402e-01	0.037
Phospholipid metabolism	R-HSA-1483257	9.193812e-01	0.037
FCERI mediated MAPK activation	R-HSA-2871796	9.271783e-01	0.033
Azathioprine ADME	R-HSA-9748787	9.327286e-01	0.030
Signaling by FGFR2 in disease	R-HSA-5655253	9.327286e-01	0.030
G alpha (i) signalling events	R-HSA-418594	9.331699e-01	0.030
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.349312e-01	0.029
The phototransduction cascade	R-HSA-2514856	9.357928e-01	0.029
Signaling by GPCR	R-HSA-372790	9.369035e-01	0.028
Role of phospholipids in phagocytosis	R-HSA-2029485	9.383984e-01	0.028
RNA Polymerase I Promoter Escape	R-HSA-73772	9.387177e-01	0.027
G alpha (s) signalling events	R-HSA-418555	9.399206e-01	0.027
Nucleotide biosynthesis	R-HSA-8956320	9.415094e-01	0.026
Neurotransmitter release cycle	R-HSA-112310	9.441590e-01	0.025
Glucuronidation	R-HSA-156588	9.441742e-01	0.025
Paracetamol ADME	R-HSA-9753281	9.467177e-01	0.024
Metabolism of amine-derived hormones	R-HSA-209776	9.491454e-01	0.023
Keratinization	R-HSA-6805567	9.506892e-01	0.022
Dectin-2 family	R-HSA-5621480	9.514627e-01	0.022
FCGR activation	R-HSA-2029481	9.521332e-01	0.021
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.536746e-01	0.021
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.557857e-01	0.020
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.578008e-01	0.019
tRNA Aminoacylation	R-HSA-379724	9.578008e-01	0.019
Glutathione conjugation	R-HSA-156590	9.578008e-01	0.019
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.590129e-01	0.018
Nucleotide salvage	R-HSA-8956321	9.597242e-01	0.018
Collagen degradation	R-HSA-1442490	9.597242e-01	0.018
NCAM signaling for neurite out-growth	R-HSA-375165	9.615600e-01	0.017
Transcriptional regulation of granulopoiesis	R-HSA-9616222	9.615600e-01	0.017
Signaling by PDGF	R-HSA-186797	9.615600e-01	0.017
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.633122e-01	0.016
Xenobiotics	R-HSA-211981	9.649847e-01	0.015
CD22 mediated BCR regulation	R-HSA-5690714	9.649847e-01	0.015
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.681046e-01	0.014
SLC-mediated transport of amino acids	R-HSA-9958863	9.695589e-01	0.013
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.735362e-01	0.012
Retinoid metabolism and transport	R-HSA-975634	9.747431e-01	0.011
Metabolism of porphyrins	R-HSA-189445	9.747431e-01	0.011
Purine catabolism	R-HSA-74259	9.758951e-01	0.011
Aspirin ADME	R-HSA-9749641	9.769945e-01	0.010
Citric acid cycle (TCA cycle)	R-HSA-71403	9.790455e-01	0.009
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.809138e-01	0.008
Integrin cell surface interactions	R-HSA-216083	9.817846e-01	0.008
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.821280e-01	0.008
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.826158e-01	0.008
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.828304e-01	0.008
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.841661e-01	0.007
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.841661e-01	0.007
Transport of small molecules	R-HSA-382551	9.866994e-01	0.006
Class B/2 (Secretin family receptors)	R-HSA-373080	9.900764e-01	0.004
Mitochondrial protein degradation	R-HSA-9837999	9.921447e-01	0.003
Collagen formation	R-HSA-1474290	9.921447e-01	0.003
Mitochondrial translation elongation	R-HSA-5389840	9.931728e-01	0.003
Mitochondrial translation initiation	R-HSA-5368286	9.937824e-01	0.003
Synthesis of bile acids and bile salts	R-HSA-192105	9.940665e-01	0.003
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.950790e-01	0.002
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.955186e-01	0.002
Visual phototransduction	R-HSA-2187338	9.960562e-01	0.002
Peptide ligand-binding receptors	R-HSA-375276	9.960688e-01	0.002
Mitochondrial translation termination	R-HSA-5419276	9.964535e-01	0.002
Bile acid and bile salt metabolism	R-HSA-194068	9.966157e-01	0.001
Bacterial Infection Pathways	R-HSA-9824439	9.966460e-01	0.001
Nucleotide catabolism	R-HSA-8956319	9.987923e-01	0.001
Drug ADME	R-HSA-9748784	9.989073e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.989692e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.989988e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.992762e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.992789e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.993202e-01	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.994558e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.996082e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.996139e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.996224e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.996317e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.998237e-01	0.000
Diseases of metabolism	R-HSA-5668914	9.998782e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999022e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999161e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999186e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999220e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999244e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999285e-01	0.000
GPCR ligand binding	R-HSA-500792	9.999986e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999995e-01	0.000
Biological oxidations	R-HSA-211859	9.999998e-01	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
M Phase	R-HSA-68886	1.110223e-16	15.955
Cell Cycle, Mitotic	R-HSA-69278	1.110223e-16	15.955
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955
Axon guidance	R-HSA-422475	1.110223e-16	15.955
Nervous system development	R-HSA-9675108	1.110223e-16	15.955
Cellular responses to stimuli	R-HSA-8953897	1.110223e-16	15.955
Cellular responses to stress	R-HSA-2262752	1.110223e-16	15.955
Mitotic Prophase	R-HSA-68875	6.661338e-16	15.176
Cell-Cell communication	R-HSA-1500931	1.443290e-15	14.841
Transcriptional regulation by small RNAs	R-HSA-5578749	8.104628e-15	14.091
Developmental Biology	R-HSA-1266738	1.121325e-14	13.950
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.521006e-14	13.818
HDACs deacetylate histones	R-HSA-3214815	1.443290e-14	13.841
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.153833e-14	13.667
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	3.619327e-14	13.441
RNA Polymerase I Promoter Opening	R-HSA-73728	3.552714e-14	13.449
Assembly of the ORC complex at the origin of replication	R-HSA-68616	6.261658e-14	13.203
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	8.038015e-14	13.095
Regulation of CDH1 Expression and Function	R-HSA-9764265	8.038015e-14	13.095
DNA methylation	R-HSA-5334118	9.869883e-14	13.006
Viral Infection Pathways	R-HSA-9824446	1.290079e-13	12.889
HCMV Early Events	R-HSA-9609690	1.713074e-13	12.766
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	2.975398e-13	12.526
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.909895e-13	12.536
Condensation of Prophase Chromosomes	R-HSA-2299718	3.266276e-13	12.486
PRC2 methylates histones and DNA	R-HSA-212300	3.641532e-13	12.439
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.540812e-13	12.343
Eukaryotic Translation Elongation	R-HSA-156842	4.457545e-13	12.351
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	5.608847e-13	12.251
Assembly of the pre-replicative complex	R-HSA-68867	5.636602e-13	12.249
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	6.932233e-13	12.159
Cap-dependent Translation Initiation	R-HSA-72737	1.198819e-12	11.921
Eukaryotic Translation Initiation	R-HSA-72613	1.198819e-12	11.921
Cell junction organization	R-HSA-446728	1.142864e-12	11.942
Adherens junctions interactions	R-HSA-418990	1.192157e-12	11.924
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.458944e-12	11.836
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.458944e-12	11.836
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.586265e-12	11.587
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	3.197220e-12	11.495
Meiotic synapsis	R-HSA-1221632	3.408607e-12	11.467
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.944955e-12	11.404
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.159006e-12	11.381
Packaging Of Telomere Ends	R-HSA-171306	4.375722e-12	11.359
SIRT1 negatively regulates rRNA expression	R-HSA-427359	4.959810e-12	11.305
HCMV Infection	R-HSA-9609646	5.617840e-12	11.250
Signaling by ROBO receptors	R-HSA-376176	7.266743e-12	11.139
Defective pyroptosis	R-HSA-9710421	7.529977e-12	11.123
Meiosis	R-HSA-1500620	1.030598e-11	10.987
NoRC negatively regulates rRNA expression	R-HSA-427413	1.207157e-11	10.918
Meiotic recombination	R-HSA-912446	1.336897e-11	10.874
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.375355e-11	10.862
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.504408e-11	10.823
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.476652e-11	10.831
Nucleosome assembly	R-HSA-774815	1.476652e-11	10.831
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.516964e-11	10.819
Gene Silencing by RNA	R-HSA-211000	1.715694e-11	10.766
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.956468e-11	10.709
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	2.083944e-11	10.681
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.012790e-11	10.696
Cell-cell junction organization	R-HSA-421270	2.183642e-11	10.661
DNA Replication Pre-Initiation	R-HSA-69002	2.526157e-11	10.598
Regulation of endogenous retroelements	R-HSA-9842860	2.627021e-11	10.581
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	2.929645e-11	10.533
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	3.793932e-11	10.421
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.568157e-11	10.340
RNA Polymerase I Transcription	R-HSA-73864	6.613543e-11	10.180
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	7.445455e-11	10.128
Maternal to zygotic transition (MZT)	R-HSA-9816359	9.749512e-11	10.011
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.042991e-10	9.982
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.180716e-10	9.928
RNA Polymerase I Promoter Escape	R-HSA-73772	1.262249e-10	9.899
Oxidative Stress Induced Senescence	R-HSA-2559580	1.302822e-10	9.885
Peptide chain elongation	R-HSA-156902	1.360575e-10	9.866
DNA Double Strand Break Response	R-HSA-5693606	1.639374e-10	9.785
Recycling pathway of L1	R-HSA-437239	2.033301e-10	9.692
Influenza Infection	R-HSA-168255	2.101027e-10	9.678
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	2.300525e-10	9.638
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.359192e-10	9.627
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	2.384110e-10	9.623
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.521932e-10	9.598
Cellular Senescence	R-HSA-2559583	2.400081e-10	9.620
Metabolism of RNA	R-HSA-8953854	2.864161e-10	9.543
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.082271e-10	9.511
Estrogen-dependent gene expression	R-HSA-9018519	3.046363e-10	9.516
Cleavage of the damaged pyrimidine	R-HSA-110329	3.185052e-10	9.497
Depyrimidination	R-HSA-73928	3.185052e-10	9.497
Cleavage of the damaged purine	R-HSA-110331	3.445826e-10	9.463
Depurination	R-HSA-73927	4.814205e-10	9.317
Mitotic Anaphase	R-HSA-68882	5.449365e-10	9.264
L1CAM interactions	R-HSA-373760	5.858831e-10	9.232
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	6.371335e-10	9.196
Mitotic Metaphase and Anaphase	R-HSA-2555396	6.123378e-10	9.213
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	6.714153e-10	9.173
Selective autophagy	R-HSA-9663891	7.002982e-10	9.155
Amyloid fiber formation	R-HSA-977225	7.014537e-10	9.154
Formation of a pool of free 40S subunits	R-HSA-72689	8.109861e-10	9.091
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	8.924422e-10	9.049
Aggrephagy	R-HSA-9646399	9.166663e-10	9.038
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.419545e-10	9.026
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.419545e-10	9.026
DNA Replication	R-HSA-69306	1.069243e-09	8.971
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.128537e-09	8.947
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.205778e-09	8.919
Translation initiation complex formation	R-HSA-72649	1.417213e-09	8.849
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.408534e-09	8.851
Ribosome-associated quality control	R-HSA-9948299	1.660733e-09	8.780
HATs acetylate histones	R-HSA-3214847	1.688986e-09	8.772
Transcriptional regulation by RUNX1	R-HSA-8878171	1.696377e-09	8.770
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	1.706750e-09	8.768
Diseases of programmed cell death	R-HSA-9645723	3.458980e-09	8.461
G2/M Checkpoints	R-HSA-69481	3.893848e-09	8.410
Cell Cycle Checkpoints	R-HSA-69620	4.924723e-09	8.308
Chromosome Maintenance	R-HSA-73886	5.503341e-09	8.259
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	6.034743e-09	8.219
Apoptotic execution phase	R-HSA-75153	6.959086e-09	8.157
Signaling by NOTCH	R-HSA-157118	7.471295e-09	8.127
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.632450e-09	8.064
Transcriptional regulation of granulopoiesis	R-HSA-9616222	9.702984e-09	8.013
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.075960e-08	7.968
Ribosomal scanning and start codon recognition	R-HSA-72702	1.389724e-08	7.857
Chaperonin-mediated protein folding	R-HSA-390466	1.367165e-08	7.864
Eukaryotic Translation Termination	R-HSA-72764	1.728434e-08	7.762
Processing of DNA double-strand break ends	R-HSA-5693607	1.782239e-08	7.749
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.006174e-08	7.698
Autophagy	R-HSA-9612973	2.133268e-08	7.671
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.189374e-08	7.660
Cellular response to heat stress	R-HSA-3371556	2.203988e-08	7.657
G2/M DNA damage checkpoint	R-HSA-69473	2.276368e-08	7.643
Telomere Maintenance	R-HSA-157579	2.413767e-08	7.617
Reproduction	R-HSA-1474165	2.686679e-08	7.571
Co-inhibition by PD-1	R-HSA-389948	3.059246e-08	7.514
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	3.484541e-08	7.458
Macroautophagy	R-HSA-1632852	3.581639e-08	7.446
Protein folding	R-HSA-391251	3.892154e-08	7.410
Selenocysteine synthesis	R-HSA-2408557	4.598794e-08	7.337
ESR-mediated signaling	R-HSA-8939211	5.015487e-08	7.300
Transport of connexons to the plasma membrane	R-HSA-190872	5.423946e-08	7.266
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	5.506980e-08	7.259
Separation of Sister Chromatids	R-HSA-2467813	5.588428e-08	7.253
Homology Directed Repair	R-HSA-5693538	5.596280e-08	7.252
Viral mRNA Translation	R-HSA-192823	6.277552e-08	7.202
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.016280e-08	7.154
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	7.078554e-08	7.150
Signal Transduction	R-HSA-162582	8.020952e-08	7.096
HCMV Late Events	R-HSA-9610379	8.308432e-08	7.080
rRNA processing in the nucleus and cytosol	R-HSA-8868773	8.514270e-08	7.070
Gap junction trafficking and regulation	R-HSA-157858	8.960915e-08	7.048
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	9.262762e-08	7.033
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	9.797738e-08	7.009
Regulation of T cell activation by CD28 family	R-HSA-388841	1.010295e-07	6.996
Base Excision Repair	R-HSA-73884	1.033520e-07	6.986
Chromatin modifying enzymes	R-HSA-3247509	1.102545e-07	6.958
SARS-CoV-1-host interactions	R-HSA-9692914	1.145467e-07	6.941
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.237504e-07	6.907
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	1.325744e-07	6.878
Downregulation of ERBB4 signaling	R-HSA-1253288	1.599417e-07	6.796
Ub-specific processing proteases	R-HSA-5689880	1.717804e-07	6.765
DNA Double-Strand Break Repair	R-HSA-5693532	1.753297e-07	6.756
SARS-CoV-1 Infection	R-HSA-9678108	2.128902e-07	6.672
Post NMDA receptor activation events	R-HSA-438064	2.728875e-07	6.564
Cellular response to starvation	R-HSA-9711097	3.089261e-07	6.510
PKR-mediated signaling	R-HSA-9833482	3.179529e-07	6.498
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	3.372461e-07	6.472
Activation of HOX genes during differentiation	R-HSA-5619507	3.372461e-07	6.472
Infectious disease	R-HSA-5663205	3.659679e-07	6.437
Chromatin organization	R-HSA-4839726	4.217978e-07	6.375
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	4.295291e-07	6.367
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	4.368600e-07	6.360
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	4.582647e-07	6.339
TCF dependent signaling in response to WNT	R-HSA-201681	4.867935e-07	6.313
Ephrin signaling	R-HSA-3928664	5.118230e-07	6.291
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	5.933448e-07	6.227
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	5.933448e-07	6.227
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	5.933448e-07	6.227
EPH-Ephrin signaling	R-HSA-2682334	6.890286e-07	6.162
Gap junction trafficking	R-HSA-190828	9.144386e-07	6.039
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.363025e-07	6.029
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.121294e-06	5.950
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.410703e-06	5.851
Mitotic Prometaphase	R-HSA-68877	1.281836e-06	5.892
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	1.411891e-06	5.850
Striated Muscle Contraction	R-HSA-390522	1.824529e-06	5.739
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	1.865989e-06	5.729
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.894441e-06	5.723
Signaling by ALK in cancer	R-HSA-9700206	1.894441e-06	5.723
G2/M Transition	R-HSA-69275	1.928910e-06	5.715
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	2.201399e-06	5.657
Mitotic G2-G2/M phases	R-HSA-453274	2.321797e-06	5.634
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.398638e-06	5.620
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.443642e-06	5.612
Regulation of CDH1 Function	R-HSA-9764561	2.457499e-06	5.610
ISG15 antiviral mechanism	R-HSA-1169408	2.620040e-06	5.582
Epigenetic regulation of gene expression	R-HSA-212165	2.840707e-06	5.547
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.163008e-06	5.500
Translation	R-HSA-72766	3.306260e-06	5.481
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	3.639171e-06	5.439
SARS-CoV Infections	R-HSA-9679506	3.828314e-06	5.417
SARS-CoV-2-host interactions	R-HSA-9705683	3.833788e-06	5.416
HSF1-dependent transactivation	R-HSA-3371571	3.857027e-06	5.414
Chaperone Mediated Autophagy	R-HSA-9613829	4.394233e-06	5.357
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	4.634300e-06	5.334
Downregulation of ERBB2 signaling	R-HSA-8863795	4.100356e-06	5.387
Apoptosis	R-HSA-109581	4.497786e-06	5.347
Deubiquitination	R-HSA-5688426	4.732547e-06	5.325
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	5.154179e-06	5.288
rRNA processing	R-HSA-72312	5.276693e-06	5.278
Selenoamino acid metabolism	R-HSA-2408522	5.446507e-06	5.264
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	6.143037e-06	5.212
Folding of actin by CCT/TriC	R-HSA-390450	6.731100e-06	5.172
Signaling by WNT	R-HSA-195721	6.986855e-06	5.156
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	7.277797e-06	5.138
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	7.277797e-06	5.138
Signaling downstream of RAS mutants	R-HSA-9649948	7.277797e-06	5.138
Signaling by RAS mutants	R-HSA-6802949	7.277797e-06	5.138
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	7.966066e-06	5.099
Post-chaperonin tubulin folding pathway	R-HSA-389977	8.496191e-06	5.071
Metalloprotease DUBs	R-HSA-5689901	9.195612e-06	5.036
mRNA Splicing - Major Pathway	R-HSA-72163	1.091357e-05	4.962
Programmed Cell Death	R-HSA-5357801	1.097221e-05	4.960
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.120052e-05	4.951
Nuclear Envelope Breakdown	R-HSA-2980766	1.129581e-05	4.947
Interleukin-12 signaling	R-HSA-9020591	1.237371e-05	4.908
Cytokine Signaling in Immune system	R-HSA-1280215	1.270011e-05	4.896
Gap junction assembly	R-HSA-190861	1.360623e-05	4.866
Signaling by RAF1 mutants	R-HSA-9656223	1.370888e-05	4.863
Host Interactions of HIV factors	R-HSA-162909	1.718181e-05	4.765
HSF1 activation	R-HSA-3371511	2.094929e-05	4.679
mRNA Splicing	R-HSA-72172	2.636731e-05	4.579
EPHB-mediated forward signaling	R-HSA-3928662	2.433392e-05	4.614
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	2.517196e-05	4.599
RMTs methylate histone arginines	R-HSA-3214858	2.433392e-05	4.614
Interferon Signaling	R-HSA-913531	2.416983e-05	4.617
Glycolysis	R-HSA-70171	3.006183e-05	4.522
FLT3 signaling by CBL mutants	R-HSA-9706377	3.802406e-05	4.420
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.944701e-05	4.404
Protein ubiquitination	R-HSA-8852135	4.124862e-05	4.385
Attenuation phase	R-HSA-3371568	4.634327e-05	4.334
Interleukin-12 family signaling	R-HSA-447115	5.955854e-05	4.225
DNA Repair	R-HSA-73894	6.107851e-05	4.214
HIV Life Cycle	R-HSA-162587	6.486598e-05	4.188
SARS-CoV-2 Infection	R-HSA-9694516	7.056061e-05	4.151
Nuclear import of Rev protein	R-HSA-180746	7.258621e-05	4.139
Signaling by ERBB2	R-HSA-1227986	7.587694e-05	4.120
Gene expression (Transcription)	R-HSA-74160	7.605215e-05	4.119
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.005839e-05	4.045
Hedgehog 'off' state	R-HSA-5610787	9.771995e-05	4.010
Developmental Lineages of the Mammary Gland	R-HSA-9924644	1.025021e-04	3.989
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.025021e-04	3.989
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.066614e-04	3.972
Smooth Muscle Contraction	R-HSA-445355	1.089103e-04	3.963
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.114676e-04	3.953
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.263947e-04	3.898
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.267249e-04	3.897
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	1.282381e-04	3.892
Late Phase of HIV Life Cycle	R-HSA-162599	1.348423e-04	3.870
HIV Infection	R-HSA-162906	1.352016e-04	3.869
Oncogenic MAPK signaling	R-HSA-6802957	1.422197e-04	3.847
Disease	R-HSA-1643685	1.605466e-04	3.794
UCH proteinases	R-HSA-5689603	1.684045e-04	3.774
Signaling by EGFR	R-HSA-177929	1.686729e-04	3.773
Signaling by Hippo	R-HSA-2028269	1.795526e-04	3.746
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.825712e-04	3.739
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.162861e-04	3.665
Interactions of Rev with host cellular proteins	R-HSA-177243	2.162861e-04	3.665
Glucose metabolism	R-HSA-70326	2.305683e-04	3.637
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.463347e-04	3.608
Long-term potentiation	R-HSA-9620244	2.587331e-04	3.587
Muscle contraction	R-HSA-397014	2.741338e-04	3.562
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.809948e-04	3.551
Kinesins	R-HSA-983189	2.902656e-04	3.537
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.957085e-04	3.529
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	2.957085e-04	3.529
Signaling by Nuclear Receptors	R-HSA-9006931	2.972584e-04	3.527
MAP2K and MAPK activation	R-HSA-5674135	2.995244e-04	3.524
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.022587e-04	3.520
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.075485e-04	3.512
Myoclonic epilepsy of Lafora	R-HSA-3785653	3.075485e-04	3.512
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.075485e-04	3.512
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	3.529960e-04	3.452
Mitophagy	R-HSA-5205647	3.529960e-04	3.452
Signal transduction by L1	R-HSA-445144	3.848905e-04	3.415
Negative regulation of MET activity	R-HSA-6807004	3.848905e-04	3.415
Nephrin family interactions	R-HSA-373753	3.848905e-04	3.415
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	4.191420e-04	3.378
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	4.555243e-04	3.341
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.846672e-04	3.315
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.846672e-04	3.315
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	4.846672e-04	3.315
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.366569e-04	3.270
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.366569e-04	3.270
Spry regulation of FGF signaling	R-HSA-1295596	5.366569e-04	3.270
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.394176e-04	3.268
Late endosomal microautophagy	R-HSA-9615710	5.713928e-04	3.243
Vpr-mediated nuclear import of PICs	R-HSA-180910	5.821450e-04	3.235
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.040397e-04	3.219
Listeria monocytogenes entry into host cells	R-HSA-8876384	6.040397e-04	3.219
Signaling by Hedgehog	R-HSA-5358351	6.222261e-04	3.206
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	6.304277e-04	3.200
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	6.516307e-04	3.186
Josephin domain DUBs	R-HSA-5689877	6.516307e-04	3.186
Pexophagy	R-HSA-9664873	6.516307e-04	3.186
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	6.846240e-04	3.165
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	8.152697e-04	3.089
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	8.152697e-04	3.089
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.237693e-04	3.140
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	7.237693e-04	3.140
Neutrophil degranulation	R-HSA-6798695	7.978333e-04	3.098
mTORC1-mediated signalling	R-HSA-166208	7.456423e-04	3.127
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.152697e-04	3.089
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	6.812507e-04	3.167
Negative regulation of FLT3	R-HSA-9706369	6.991795e-04	3.155
NS1 Mediated Effects on Host Pathways	R-HSA-168276	7.937136e-04	3.100
KEAP1-NFE2L2 pathway	R-HSA-9755511	6.958465e-04	3.157
Maturation of protein E	R-HSA-9683683	8.746911e-04	3.058
Maturation of protein E	R-HSA-9694493	8.746911e-04	3.058
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	9.049592e-04	3.043
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	9.049592e-04	3.043
Interactions of Vpr with host cellular proteins	R-HSA-176033	9.208416e-04	3.036
RNA Polymerase II Transcription	R-HSA-73857	9.313126e-04	3.031
MAPK family signaling cascades	R-HSA-5683057	1.036575e-03	2.984
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.064016e-03	2.973
Developmental Cell Lineages	R-HSA-9734767	1.092171e-03	2.962
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.106961e-03	2.956
IPs transport between nucleus and cytosol	R-HSA-1855170	1.136467e-03	2.944
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.190175e-03	2.924
NF-kB is activated and signals survival	R-HSA-209560	1.225107e-03	2.912
Signaling by VEGF	R-HSA-194138	1.294776e-03	2.888
G1/S Transition	R-HSA-69206	1.294776e-03	2.888
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.331119e-03	2.876
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	1.377271e-03	2.861
mRNA 3'-end processing	R-HSA-72187	1.377271e-03	2.861
MAPK1/MAPK3 signaling	R-HSA-5684996	1.386022e-03	2.858
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.421004e-03	2.847
Semaphorin interactions	R-HSA-373755	1.441811e-03	2.841
Signaling by PTK6	R-HSA-8848021	1.441811e-03	2.841
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.441811e-03	2.841
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.552901e-03	2.809
Signaling by EGFR in Cancer	R-HSA-1643713	1.593160e-03	2.798
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.604722e-03	2.795
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.622076e-03	2.790
VLDLR internalisation and degradation	R-HSA-8866427	1.622076e-03	2.790
p75NTR recruits signalling complexes	R-HSA-209543	1.622076e-03	2.790
Cilium Assembly	R-HSA-5617833	1.701542e-03	2.769
Regulation of signaling by CBL	R-HSA-912631	1.757151e-03	2.755
RAF/MAP kinase cascade	R-HSA-5673001	1.946475e-03	2.711
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.958666e-03	2.708
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	1.958666e-03	2.708
Regulation of PTEN localization	R-HSA-8948747	1.969160e-03	2.706
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	2.073991e-03	2.683
Regulation of TP53 Degradation	R-HSA-6804757	2.078078e-03	2.682
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.106177e-03	2.677
Immune System	R-HSA-168256	2.106293e-03	2.676
Glycogen synthesis	R-HSA-3322077	2.150381e-03	2.667
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	2.191421e-03	2.659
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	2.231285e-03	2.651
Adaptive Immune System	R-HSA-1280218	2.303934e-03	2.638
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.687926e-03	2.571
NRIF signals cell death from the nucleus	R-HSA-205043	2.687926e-03	2.571
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.687926e-03	2.571
Formation of annular gap junctions	R-HSA-196025	2.768813e-03	2.558
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.768813e-03	2.558
Modulation by Mtb of host immune system	R-HSA-9637628	2.768813e-03	2.558
Sema3A PAK dependent Axon repulsion	R-HSA-399954	3.377947e-03	2.471
EGFR downregulation	R-HSA-182971	3.537800e-03	2.451
Regulation of mitotic cell cycle	R-HSA-453276	3.242279e-03	2.489
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.242279e-03	2.489
DCC mediated attractive signaling	R-HSA-418885	3.377947e-03	2.471
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	3.377947e-03	2.471
Budding and maturation of HIV virion	R-HSA-162588	3.537800e-03	2.451
Protein methylation	R-HSA-8876725	3.377947e-03	2.471
p75NTR signals via NF-kB	R-HSA-193639	3.377947e-03	2.471
Intraflagellar transport	R-HSA-5620924	2.976420e-03	2.526
Metabolism of non-coding RNA	R-HSA-194441	3.025895e-03	2.519
snRNP Assembly	R-HSA-191859	3.025895e-03	2.519
RNA Polymerase II Transcription Termination	R-HSA-73856	3.710562e-03	2.431
Cell-extracellular matrix interactions	R-HSA-446353	3.377947e-03	2.471
Transcriptional Regulation by E2F6	R-HSA-8953750	3.120934e-03	2.506
Regulation of TP53 Expression and Degradation	R-HSA-6806003	3.120934e-03	2.506
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	2.837418e-03	2.547
Signaling by Interleukins	R-HSA-449147	3.662350e-03	2.436
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.732065e-03	2.428
Gap junction degradation	R-HSA-190873	3.766367e-03	2.424
Regulation of gap junction activity	R-HSA-191650	3.944545e-03	2.404
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	4.015731e-03	2.396
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	4.015731e-03	2.396
FLT3 Signaling	R-HSA-9607240	4.015731e-03	2.396
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	4.096074e-03	2.388
Signaling by ERBB4	R-HSA-1236394	4.263598e-03	2.370
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	4.512541e-03	2.346
Loss of Nlp from mitotic centrosomes	R-HSA-380259	4.512541e-03	2.346
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.632131e-03	2.334
Non-integrin membrane-ECM interactions	R-HSA-3000171	4.655796e-03	2.332
Regulation of MECP2 expression and activity	R-HSA-9022692	4.687490e-03	2.329
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.893470e-03	2.310
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	4.927802e-03	2.307
Apoptosis induced DNA fragmentation	R-HSA-140342	4.982865e-03	2.303
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	4.991487e-03	2.302
MTOR signalling	R-HSA-165159	5.096453e-03	2.293
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	5.140738e-03	2.289
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	5.183036e-03	2.285
Clathrin-mediated endocytosis	R-HSA-8856828	5.229300e-03	2.282
DNA Damage Recognition in GG-NER	R-HSA-5696394	5.358191e-03	2.271
Nuclear events mediated by NFE2L2	R-HSA-9759194	5.397281e-03	2.268
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	5.678908e-03	2.246
AURKA Activation by TPX2	R-HSA-8854518	5.964523e-03	2.224
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	6.006392e-03	2.221
Mitotic Spindle Checkpoint	R-HSA-69618	6.090159e-03	2.215
RAF activation	R-HSA-5673000	6.098366e-03	2.215
MHC class II antigen presentation	R-HSA-2132295	6.135590e-03	2.212
Glycogen storage diseases	R-HSA-3229121	6.203613e-03	2.207
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	6.460400e-03	2.190
Platelet activation, signaling and aggregation	R-HSA-76002	6.794514e-03	2.168
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	6.912225e-03	2.160
Membrane Trafficking	R-HSA-199991	6.957991e-03	2.158
S Phase	R-HSA-69242	6.970809e-03	2.157
Myogenesis	R-HSA-525793	7.009680e-03	2.154
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.009680e-03	2.154
G1/S-Specific Transcription	R-HSA-69205	7.803991e-03	2.108
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.910247e-03	2.102
EPHA-mediated growth cone collapse	R-HSA-3928663	8.079518e-03	2.093
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	8.150564e-03	2.089
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.150564e-03	2.089
Platelet degranulation	R-HSA-114608	8.340631e-03	2.079
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	8.438525e-03	2.074
Cyclin E associated events during G1/S transition	R-HSA-69202	8.438525e-03	2.074
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.767260e-03	2.057
Ovarian tumor domain proteases	R-HSA-5689896	8.777878e-03	2.057
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	8.777878e-03	2.057
Translesion Synthesis by POLH	R-HSA-110320	8.820320e-03	2.055
Negative regulation of FGFR3 signaling	R-HSA-5654732	9.261917e-03	2.033
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	9.617845e-03	2.017
Gluconeogenesis	R-HSA-70263	9.691813e-03	2.014
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	9.938591e-03	2.003
Manipulation of host energy metabolism	R-HSA-9636667	1.085504e-02	1.964
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.188207e-02	1.925
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.013706e-02	1.994
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	1.499149e-02	1.824
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	1.211434e-02	1.917
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	1.056291e-02	1.976
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	1.354405e-02	1.868
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	1.098875e-02	1.959
Negative regulation of NOTCH4 signaling	R-HSA-9604323	1.223399e-02	1.912
Orc1 removal from chromatin	R-HSA-68949	1.412626e-02	1.850
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.076084e-02	1.968
Signaling by NOTCH4	R-HSA-9013694	1.163370e-02	1.934
Centrosome maturation	R-HSA-380287	1.255904e-02	1.901
Amplification of signal from the kinetochores	R-HSA-141424	1.113439e-02	1.953
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.113439e-02	1.953
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.211434e-02	1.917
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.198838e-02	1.921
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.056291e-02	1.976
DNA Damage Bypass	R-HSA-73893	1.068696e-02	1.971
Membrane binding and targetting of GAG proteins	R-HSA-174490	1.241286e-02	1.906
Switching of origins to a post-replicative state	R-HSA-69052	1.076084e-02	1.968
Breakdown of the nuclear lamina	R-HSA-352238	1.085504e-02	1.964
Regulation of RUNX3 expression and activity	R-HSA-8941858	1.223399e-02	1.912
Hh mutants are degraded by ERAD	R-HSA-5362768	1.357783e-02	1.867
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.241286e-02	1.906
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	1.499149e-02	1.824
Activation of NF-kappaB in B cells	R-HSA-1169091	1.290118e-02	1.889
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	1.403769e-02	1.853
Metabolism of proteins	R-HSA-392499	1.193883e-02	1.923
Negative regulation of FGFR4 signaling	R-HSA-5654733	1.056291e-02	1.976
Degradation of CDH1	R-HSA-9766229	1.068696e-02	1.971
MAP kinase activation	R-HSA-450294	1.092165e-02	1.962
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.076084e-02	1.968
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	1.013706e-02	1.994
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	1.013706e-02	1.994
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	1.211434e-02	1.917
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.403769e-02	1.853
tRNA processing in the nucleus	R-HSA-6784531	1.189297e-02	1.925
Generic Transcription Pathway	R-HSA-212436	1.475940e-02	1.831
MAPK6/MAPK4 signaling	R-HSA-5687128	1.035482e-02	1.985
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.013706e-02	1.994
IRAK1 recruits IKK complex	R-HSA-937039	1.013706e-02	1.994
Assembly Of The HIV Virion	R-HSA-175474	1.403769e-02	1.853
Organelle biogenesis and maintenance	R-HSA-1852241	1.239444e-02	1.907
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.403769e-02	1.853
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.122964e-02	1.950
Degradation of GLI1 by the proteasome	R-HSA-5610780	1.502424e-02	1.823
Negative regulation of MAPK pathway	R-HSA-5675221	1.502424e-02	1.823
Regulation of PTEN stability and activity	R-HSA-8948751	1.543393e-02	1.812
PCP/CE pathway	R-HSA-4086400	1.566845e-02	1.805
Uptake and function of diphtheria toxin	R-HSA-5336415	1.569626e-02	1.804
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.572417e-02	1.803
Cellular responses to mechanical stimuli	R-HSA-9855142	1.596105e-02	1.797
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	1.615617e-02	1.792
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	1.621978e-02	1.790
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.657706e-02	1.780
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	1.682707e-02	1.774
Integrin signaling	R-HSA-354192	1.706790e-02	1.768
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.706790e-02	1.768
Cellular response to chemical stress	R-HSA-9711123	1.724152e-02	1.763
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.788474e-02	1.748
Translesion synthesis by REV1	R-HSA-110312	1.788474e-02	1.748
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	1.788474e-02	1.748
PTEN Regulation	R-HSA-6807070	1.795871e-02	1.746
Signaling by MET	R-HSA-6806834	1.803754e-02	1.744
Hh mutants abrogate ligand secretion	R-HSA-5387390	1.824004e-02	1.739
Signaling by NOTCH3	R-HSA-9012852	1.830854e-02	1.737
Response of endothelial cells to shear stress	R-HSA-9860931	1.857617e-02	1.731
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.857617e-02	1.731
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.865490e-02	1.729
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.865490e-02	1.729
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	1.865490e-02	1.729
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.865490e-02	1.729
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.865490e-02	1.729
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.865490e-02	1.729
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.865490e-02	1.729
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.865490e-02	1.729
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	1.865490e-02	1.729
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.865490e-02	1.729
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.865490e-02	1.729
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.865490e-02	1.729
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.865490e-02	1.729
Vpu mediated degradation of CD4	R-HSA-180534	1.904646e-02	1.720
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.988110e-02	1.702
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	1.988110e-02	1.702
Cyclin D associated events in G1	R-HSA-69231	2.001680e-02	1.699
G1 Phase	R-HSA-69236	2.001680e-02	1.699
Deadenylation of mRNA	R-HSA-429947	2.100785e-02	1.678
Translesion synthesis by POLI	R-HSA-5656121	2.110266e-02	1.676
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.110266e-02	1.676
Regulation of NF-kappa B signaling	R-HSA-9758274	2.110266e-02	1.676
Regulation of BACH1 activity	R-HSA-9708530	2.110266e-02	1.676
Dual Incision in GG-NER	R-HSA-5696400	2.117594e-02	1.674
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	2.117594e-02	1.674
Negative regulation of FGFR2 signaling	R-HSA-5654727	2.117594e-02	1.674
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	2.117594e-02	1.674
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	2.117594e-02	1.674
Asymmetric localization of PCP proteins	R-HSA-4608870	2.191085e-02	1.659
Defective CFTR causes cystic fibrosis	R-HSA-5678895	2.191085e-02	1.659
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	2.191085e-02	1.659
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	2.191085e-02	1.659
Interleukin-17 signaling	R-HSA-448424	2.212480e-02	1.655
Synthesis of DNA	R-HSA-69239	2.337833e-02	1.631
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	2.346087e-02	1.630
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	2.346087e-02	1.630
Regulation of Apoptosis	R-HSA-169911	2.346087e-02	1.630
Oncogene Induced Senescence	R-HSA-2559585	2.346087e-02	1.630
Hedgehog 'on' state	R-HSA-5632684	2.374470e-02	1.624
HDMs demethylate histones	R-HSA-3214842	2.375418e-02	1.624
GRB2 events in ERBB2 signaling	R-HSA-1963640	2.465353e-02	1.608
Translesion synthesis by POLK	R-HSA-5655862	2.465353e-02	1.608
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	2.465353e-02	1.608
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	2.465353e-02	1.608
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	2.465353e-02	1.608
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.516186e-02	1.599
Regulation of TP53 Activity	R-HSA-5633007	2.565046e-02	1.591
COPI-mediated anterograde transport	R-HSA-6807878	2.583033e-02	1.588
Vif-mediated degradation of APOBEC3G	R-HSA-180585	2.590548e-02	1.587
FLT3 signaling in disease	R-HSA-9682385	2.590548e-02	1.587
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	2.672261e-02	1.573
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	2.818138e-02	1.550
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.841795e-02	1.546
Degradation of DVL	R-HSA-4641258	2.851370e-02	1.545
Degradation of AXIN	R-HSA-4641257	2.851370e-02	1.545
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	2.851370e-02	1.545
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.851370e-02	1.545
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.854389e-02	1.544
Regulation of FZD by ubiquitination	R-HSA-4641263	2.854389e-02	1.544
Viral Messenger RNA Synthesis	R-HSA-168325	2.920189e-02	1.535
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	2.991576e-02	1.524
ER Quality Control Compartment (ERQC)	R-HSA-901032	2.991576e-02	1.524
Pyruvate metabolism	R-HSA-70268	3.018835e-02	1.520
p75 NTR receptor-mediated signalling	R-HSA-193704	3.062344e-02	1.514
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	3.107145e-02	1.508
Potential therapeutics for SARS	R-HSA-9679191	3.153469e-02	1.501
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.277860e-02	1.484
Hemostasis	R-HSA-109582	3.346805e-02	1.475
Transcriptional Regulation by TP53	R-HSA-3700989	3.389823e-02	1.470
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	3.423501e-02	1.466
Stabilization of p53	R-HSA-69541	3.423501e-02	1.466
Unfolded Protein Response (UPR)	R-HSA-381119	3.555420e-02	1.449
Hedgehog ligand biogenesis	R-HSA-5358346	3.591372e-02	1.445
Termination of translesion DNA synthesis	R-HSA-5656169	3.699867e-02	1.432
Signaling by CSF3 (G-CSF)	R-HSA-9674555	3.699867e-02	1.432
Regulation of gene expression in beta cells	R-HSA-210745	3.699867e-02	1.432
Nuclear signaling by ERBB4	R-HSA-1251985	3.735428e-02	1.428
Formation of Incision Complex in GG-NER	R-HSA-5696395	3.735428e-02	1.428
Glycogen metabolism	R-HSA-8982491	3.735428e-02	1.428
IKK complex recruitment mediated by RIP1	R-HSA-937041	3.736090e-02	1.428
Cellular response to hypoxia	R-HSA-1234174	3.854934e-02	1.414
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	3.871292e-02	1.412
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	3.924098e-02	1.406
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	3.924098e-02	1.406
Defective LFNG causes SCDO3	R-HSA-5083630	3.924098e-02	1.406
NADE modulates death signalling	R-HSA-205025	3.924098e-02	1.406
MTF1 activates gene expression	R-HSA-5660489	3.924098e-02	1.406
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	3.924098e-02	1.406
PKMTs methylate histone lysines	R-HSA-3214841	4.064950e-02	1.391
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.064950e-02	1.391
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	4.064950e-02	1.391
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	4.064950e-02	1.391
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.089410e-02	1.388
Signaling by FGFR2	R-HSA-5654738	4.226988e-02	1.374
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	4.229242e-02	1.374
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	4.229242e-02	1.374
HDR through Homologous Recombination (HRR)	R-HSA-5685942	4.389777e-02	1.358
Activation of RAC1	R-HSA-428540	4.394711e-02	1.357
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	4.394711e-02	1.357
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.402666e-02	1.356
Degradation of CRY and PER proteins	R-HSA-9932298	4.412288e-02	1.355
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.412288e-02	1.355
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.412288e-02	1.355
Translation of Structural Proteins	R-HSA-9683701	4.412288e-02	1.355
Nucleotide Excision Repair	R-HSA-5696398	4.420689e-02	1.355
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	4.502866e-02	1.347
Evasion by RSV of host interferon responses	R-HSA-9833109	4.502866e-02	1.347
Regulated Necrosis	R-HSA-5218859	4.674642e-02	1.330
Transcriptional regulation by RUNX2	R-HSA-8878166	4.739658e-02	1.324
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	4.757329e-02	1.323
Basigin interactions	R-HSA-210991	4.757329e-02	1.323
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	4.757329e-02	1.323
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.777625e-02	1.321
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.940385e-02	1.306
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	4.971319e-02	1.304
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	5.041582e-02	1.297
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	5.041582e-02	1.297
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	5.131860e-02	1.290
Signaling by FGFR4	R-HSA-5654743	5.161112e-02	1.287
Response of Mtb to phagocytosis	R-HSA-9637690	5.161112e-02	1.287
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	5.165527e-02	1.287
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	5.165527e-02	1.287
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	5.320220e-02	1.274
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	5.320220e-02	1.274
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	5.320220e-02	1.274
Regulation of necroptotic cell death	R-HSA-5675482	5.402051e-02	1.267
CLEC7A (Dectin-1) signaling	R-HSA-5607764	5.500418e-02	1.260
Netrin-1 signaling	R-HSA-373752	5.562859e-02	1.255
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	5.562859e-02	1.255
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	5.562859e-02	1.255
Transmission across Chemical Synapses	R-HSA-112315	5.816664e-02	1.235
Beta-catenin independent WNT signaling	R-HSA-3858494	5.887797e-02	1.230
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	5.917648e-02	1.228
trans-Golgi Network Vesicle Budding	R-HSA-199992	5.933343e-02	1.227
Reversible hydration of carbon dioxide	R-HSA-1475029	5.941306e-02	1.226
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	5.941306e-02	1.226
Platelet Aggregation (Plug Formation)	R-HSA-76009	5.982941e-02	1.223
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	5.982941e-02	1.223
Signaling by FGFR3	R-HSA-5654741	5.982941e-02	1.223
Deadenylation-dependent mRNA decay	R-HSA-429914	6.229192e-02	1.206
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	6.397834e-02	1.194
Signaling by NOTCH2	R-HSA-1980145	6.397834e-02	1.194
NOD1/2 Signaling Pathway	R-HSA-168638	6.397834e-02	1.194
Calnexin/calreticulin cycle	R-HSA-901042	6.397834e-02	1.194
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	6.421399e-02	1.192
Regulation of pyruvate metabolism	R-HSA-9861718	6.421399e-02	1.192
Diseases of Telomere Maintenance	R-HSA-9673013	9.829279e-02	1.007
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	9.829279e-02	1.007
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	9.829279e-02	1.007
Hereditary fructose intolerance	R-HSA-5657560	9.829279e-02	1.007
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	9.829279e-02	1.007
RPIA deficiency: failed conversion of RU5P to R5P	R-HSA-6791461	9.829279e-02	1.007
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	9.829279e-02	1.007
RPIA deficiency: failed conversion of R5P to RU5P	R-HSA-5659996	9.829279e-02	1.007
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.525990e-02	1.185
PTK6 promotes HIF1A stabilization	R-HSA-8857538	7.990359e-02	1.097
G2/M DNA replication checkpoint	R-HSA-69478	7.990359e-02	1.097
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	7.990359e-02	1.097
MECP2 regulates transcription factors	R-HSA-9022707	9.544728e-02	1.020
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	9.544728e-02	1.020
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	9.544728e-02	1.020
Type I hemidesmosome assembly	R-HSA-446107	1.117632e-01	0.952
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	1.117632e-01	0.952
Lipophagy	R-HSA-9613354	1.287343e-01	0.890
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	1.287343e-01	0.890
5-Phosphoribose 1-diphosphate biosynthesis	R-HSA-73843	1.287343e-01	0.890
ALK mutants bind TKIs	R-HSA-9700645	1.287343e-01	0.890
Phosphorylation of the APC/C	R-HSA-176412	8.665844e-02	1.062
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	8.665844e-02	1.062
G beta:gamma signalling through CDC42	R-HSA-8964616	9.672534e-02	1.014
Disorders of Developmental Biology	R-HSA-9675151	9.672534e-02	1.014
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.672534e-02	1.014
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	9.672534e-02	1.014
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.072413e-01	0.970
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.072413e-01	0.970
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.181790e-01	0.927
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	8.643123e-02	1.063
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.405079e-02	1.027
Interaction between L1 and Ankyrins	R-HSA-445095	9.405079e-02	1.027
Transcriptional Regulation by MECP2	R-HSA-8986944	7.933620e-02	1.101
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	1.237637e-01	0.907
GAB1 signalosome	R-HSA-180292	1.181790e-01	0.927
PERK regulates gene expression	R-HSA-381042	6.931798e-02	1.159
E2F mediated regulation of DNA replication	R-HSA-113510	1.295103e-01	0.888
PI3K events in ERBB2 signaling	R-HSA-1963642	1.072413e-01	0.970
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.000105e-01	1.000
Negative feedback regulation of MAPK pathway	R-HSA-5674499	6.525990e-02	1.185
Calcineurin activates NFAT	R-HSA-2025928	1.287343e-01	0.890
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	9.672534e-02	1.014
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.138359e-01	0.944
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	7.990359e-02	1.097
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	1.295103e-01	0.888
Inhibition of PKR	R-HSA-169131	9.829279e-02	1.007
Cellular response to mitochondrial stress	R-HSA-9840373	1.287343e-01	0.890
Regulation of PTEN gene transcription	R-HSA-8943724	6.624396e-02	1.179
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	1.019760e-01	0.992
C-type lectin receptors (CLRs)	R-HSA-5621481	7.363778e-02	1.133
Regulation of CDH11 gene transcription	R-HSA-9762293	1.287343e-01	0.890
Vesicle-mediated transport	R-HSA-5653656	1.178471e-01	0.929
CHL1 interactions	R-HSA-447041	9.544728e-02	1.020
Regulation of RAS by GAPs	R-HSA-5658442	8.358530e-02	1.078
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	8.665844e-02	1.062
Signaling by TGFB family members	R-HSA-9006936	8.364752e-02	1.078
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	6.525990e-02	1.185
GP1b-IX-V activation signalling	R-HSA-430116	1.287343e-01	0.890
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	8.888222e-02	1.051
ER to Golgi Anterograde Transport	R-HSA-199977	9.197578e-02	1.036
Transcriptional regulation by RUNX3	R-HSA-8878159	1.124368e-01	0.949
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.675787e-02	1.062
Sema4D in semaphorin signaling	R-HSA-400685	7.912631e-02	1.102
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.170432e-01	0.932
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.170432e-01	0.932
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.170432e-01	0.932
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	1.117632e-01	0.952
G1/S DNA Damage Checkpoints	R-HSA-69615	7.898712e-02	1.102
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.287343e-01	0.890
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	7.846885e-02	1.105
Golgi-to-ER retrograde transport	R-HSA-8856688	8.773196e-02	1.057
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.117632e-01	0.952
Respiratory syncytial virus genome replication	R-HSA-9834752	1.287343e-01	0.890
TCR signaling	R-HSA-202403	1.061794e-01	0.974
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.846885e-02	1.105
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.846885e-02	1.105
Plasma lipoprotein clearance	R-HSA-8964043	9.303547e-02	1.031
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.031610e-01	0.986
Signaling by FGFR1	R-HSA-5654736	1.180051e-01	0.928
Suppression of phagosomal maturation	R-HSA-9637687	8.643123e-02	1.063
Signaling by FGFR	R-HSA-190236	1.170432e-01	0.932
IRE1alpha activates chaperones	R-HSA-381070	8.310495e-02	1.080
XBP1(S) activates chaperone genes	R-HSA-381038	1.239528e-01	0.907
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	1.181790e-01	0.927
Dual incision in TC-NER	R-HSA-6782135	1.308364e-01	0.883
Diseases of carbohydrate metabolism	R-HSA-5663084	1.308853e-01	0.883
Interleukin-1 signaling	R-HSA-9020702	1.314695e-01	0.881
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	1.330355e-01	0.876
Intracellular signaling by second messengers	R-HSA-9006925	1.335602e-01	0.874
Diseases of mitotic cell cycle	R-HSA-9675126	1.365277e-01	0.865
Protein hydroxylation	R-HSA-9629569	1.412069e-01	0.850
Interactions of Tat with host cellular proteins	R-HSA-176034	1.437586e-01	0.842
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	1.437586e-01	0.842
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	1.437586e-01	0.842
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	1.437586e-01	0.842
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	1.437586e-01	0.842
Transport of connexins along the secretory pathway	R-HSA-190827	1.437586e-01	0.842
Oligomerization of connexins into connexons	R-HSA-190704	1.437586e-01	0.842
G-protein beta:gamma signalling	R-HSA-397795	1.458220e-01	0.836
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.458220e-01	0.836
Nuclear RNA decay	R-HSA-9930044	1.458220e-01	0.836
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.458220e-01	0.836
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.462532e-01	0.835
MAPK3 (ERK1) activation	R-HSA-110056	1.462532e-01	0.835
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.462532e-01	0.835
Receptor Mediated Mitophagy	R-HSA-8934903	1.462532e-01	0.835
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	1.462532e-01	0.835
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.462532e-01	0.835
PIP3 activates AKT signaling	R-HSA-1257604	1.467190e-01	0.834
Circadian clock	R-HSA-9909396	1.505147e-01	0.822
mRNA Splicing - Minor Pathway	R-HSA-72165	1.509813e-01	0.821
Regulation of RUNX2 expression and activity	R-HSA-8939902	1.512665e-01	0.820
RSV-host interactions	R-HSA-9833110	1.520790e-01	0.818
Early Phase of HIV Life Cycle	R-HSA-162594	1.532403e-01	0.815
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.574678e-01	0.803
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.591044e-01	0.798
ABC transporter disorders	R-HSA-5619084	1.619144e-01	0.791
PECAM1 interactions	R-HSA-210990	1.642216e-01	0.785
Mitochondrial calcium ion transport	R-HSA-8949215	1.655821e-01	0.781
rRNA modification in the nucleus and cytosol	R-HSA-6790901	1.656280e-01	0.781
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.674011e-01	0.776
Sensory processing of sound	R-HSA-9659379	1.684878e-01	0.773
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	1.730179e-01	0.762
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	1.741760e-01	0.759
FGFR2 alternative splicing	R-HSA-6803529	1.782043e-01	0.749
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	1.782043e-01	0.749
MyD88 dependent cascade initiated on endosome	R-HSA-975155	1.799202e-01	0.745
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	1.825500e-01	0.739
PI3K events in ERBB4 signaling	R-HSA-1250342	1.825500e-01	0.739
Integration of provirus	R-HSA-162592	1.825500e-01	0.739
Condensation of Prometaphase Chromosomes	R-HSA-2514853	1.825500e-01	0.739
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	1.825500e-01	0.739
Lysosome Vesicle Biogenesis	R-HSA-432720	1.852543e-01	0.732
RUNX2 regulates bone development	R-HSA-8941326	1.852543e-01	0.732
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.857486e-01	0.731
MyD88-independent TLR4 cascade	R-HSA-166166	1.857486e-01	0.731
Death Receptor Signaling	R-HSA-73887	1.860866e-01	0.730
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	1.869346e-01	0.728
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	1.869346e-01	0.728
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	1.869346e-01	0.728
Potassium transport channels	R-HSA-1296067	1.869346e-01	0.728
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	1.869346e-01	0.728
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	1.869346e-01	0.728
Regulation of cortical dendrite branching	R-HSA-8985801	1.869346e-01	0.728
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	1.869346e-01	0.728
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	1.869346e-01	0.728
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	1.869346e-01	0.728
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	1.869346e-01	0.728
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.910789e-01	0.719
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	1.910789e-01	0.719
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.910789e-01	0.719
Syndecan interactions	R-HSA-3000170	1.910789e-01	0.719
Post-translational protein modification	R-HSA-597592	1.935697e-01	0.713
Neuronal System	R-HSA-112316	1.953209e-01	0.709
Disorders of Nervous System Development	R-HSA-9697154	2.011564e-01	0.696
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	2.011564e-01	0.696
Pervasive developmental disorders	R-HSA-9005895	2.011564e-01	0.696
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.011564e-01	0.696
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	2.011564e-01	0.696
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	2.037190e-01	0.691
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	2.041787e-01	0.690
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.041787e-01	0.690
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.041787e-01	0.690
Neurodegenerative Diseases	R-HSA-8863678	2.041787e-01	0.690
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.096352e-01	0.679
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	2.168304e-01	0.664
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	2.168304e-01	0.664
RAS processing	R-HSA-9648002	2.168304e-01	0.664
VEGFR2 mediated cell proliferation	R-HSA-5218921	2.174770e-01	0.663
Interleukin-7 signaling	R-HSA-1266695	2.174770e-01	0.663
Formation of axial mesoderm	R-HSA-9796292	2.199663e-01	0.658
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	2.199663e-01	0.658
Processing of SMDT1	R-HSA-8949664	2.199663e-01	0.658
Platelet Adhesion to exposed collagen	R-HSA-75892	2.199663e-01	0.658
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	2.199663e-01	0.658
Maturation of nucleoprotein	R-HSA-9683610	2.199663e-01	0.658
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.199777e-01	0.658
ABC-family proteins mediated transport	R-HSA-382556	2.207532e-01	0.656
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	2.223722e-01	0.653
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	2.249336e-01	0.648
Disorders of transmembrane transporters	R-HSA-5619115	2.264687e-01	0.645
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.279358e-01	0.642
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.279358e-01	0.642
MET interacts with TNS proteins	R-HSA-8875513	2.279358e-01	0.642
CASP5-mediated substrate cleavage	R-HSA-9960525	2.279358e-01	0.642
CASP4-mediated substrate cleavage	R-HSA-9960519	2.279358e-01	0.642
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.281926e-01	0.642
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.309477e-01	0.636
MET activates PTK2 signaling	R-HSA-8874081	2.309477e-01	0.636
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.386348e-01	0.622
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.389121e-01	0.622
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.389121e-01	0.622
Regulation of KIT signaling	R-HSA-1433559	2.389121e-01	0.622
Signal regulatory protein family interactions	R-HSA-391160	2.389121e-01	0.622
TNF signaling	R-HSA-75893	2.391084e-01	0.621
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.445656e-01	0.612
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.445656e-01	0.612
ER-Phagosome pathway	R-HSA-1236974	2.476246e-01	0.606
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.488945e-01	0.604
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	2.548093e-01	0.594
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	2.548093e-01	0.594
Downstream TCR signaling	R-HSA-202424	2.553414e-01	0.593
Processive synthesis on the lagging strand	R-HSA-69183	2.579323e-01	0.588
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	2.579323e-01	0.588
G beta:gamma signalling through BTK	R-HSA-8964315	2.579323e-01	0.588
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.579323e-01	0.588
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.579323e-01	0.588
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.579323e-01	0.588
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	2.579323e-01	0.588
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.579323e-01	0.588
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.579323e-01	0.588
Early SARS-CoV-2 Infection Events	R-HSA-9772572	2.582257e-01	0.588
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	2.583060e-01	0.588
Pyroptosis	R-HSA-5620971	2.583060e-01	0.588
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.609188e-01	0.583
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.668719e-01	0.574
Signaling by MAP2K mutants	R-HSA-9652169	2.668719e-01	0.574
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	2.668719e-01	0.574
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	2.668719e-01	0.574
Dopamine receptors	R-HSA-390651	2.668719e-01	0.574
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.668719e-01	0.574
FLT3 signaling through SRC family kinases	R-HSA-9706374	2.668719e-01	0.574
Peroxisomal protein import	R-HSA-9033241	2.679184e-01	0.572
Regulation of beta-cell development	R-HSA-186712	2.679184e-01	0.572
Signaling by NOTCH1	R-HSA-1980143	2.706034e-01	0.568
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	2.711014e-01	0.567
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	2.721455e-01	0.565
Regulation of CDH11 Expression and Function	R-HSA-9759475	2.721455e-01	0.565
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	2.749728e-01	0.561
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	2.749728e-01	0.561
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	2.769714e-01	0.558
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.769714e-01	0.558
Prolonged ERK activation events	R-HSA-169893	2.769714e-01	0.558
Translation of Structural Proteins	R-HSA-9694635	2.793136e-01	0.554
Stimuli-sensing channels	R-HSA-2672351	2.846311e-01	0.546
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.860612e-01	0.544
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	2.860612e-01	0.544
G alpha (12/13) signalling events	R-HSA-416482	2.880868e-01	0.540
Fanconi Anemia Pathway	R-HSA-6783310	2.950188e-01	0.530
Somitogenesis	R-HSA-9824272	2.950188e-01	0.530
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.959790e-01	0.529
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	2.959790e-01	0.529
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.959790e-01	0.529
Response to metal ions	R-HSA-5660526	2.959790e-01	0.529
Trafficking of AMPA receptors	R-HSA-399719	3.000313e-01	0.523
Downstream signal transduction	R-HSA-186763	3.000313e-01	0.523
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	3.029604e-01	0.519
IRS activation	R-HSA-74713	3.038465e-01	0.517
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	3.038465e-01	0.517
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	3.038465e-01	0.517
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	3.038465e-01	0.517
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	3.038465e-01	0.517
Reelin signalling pathway	R-HSA-8866376	3.038465e-01	0.517
Muscarinic acetylcholine receptors	R-HSA-390648	3.038465e-01	0.517
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	3.038465e-01	0.517
Nectin/Necl trans heterodimerization	R-HSA-420597	3.038465e-01	0.517
SMAC (DIABLO) binds to IAPs	R-HSA-111463	3.038465e-01	0.517
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	3.057993e-01	0.515
Regulation of TNFR1 signaling	R-HSA-5357905	3.065154e-01	0.514
DNA strand elongation	R-HSA-69190	3.140350e-01	0.503
G0 and Early G1	R-HSA-1538133	3.140350e-01	0.503
Inwardly rectifying K+ channels	R-HSA-1296065	3.140350e-01	0.503
Inositol phosphate metabolism	R-HSA-1483249	3.144465e-01	0.502
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.149102e-01	0.502
Elevation of cytosolic Ca2+ levels	R-HSA-139853	3.149102e-01	0.502
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.149102e-01	0.502
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.149102e-01	0.502
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.236152e-01	0.490
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.280523e-01	0.484
Activation of ATR in response to replication stress	R-HSA-176187	3.280523e-01	0.484
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	3.280523e-01	0.484
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.280523e-01	0.484
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.280523e-01	0.484
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.280523e-01	0.484
GPER1 signaling	R-HSA-9634597	3.296320e-01	0.482
Co-stimulation by CD28	R-HSA-389356	3.296320e-01	0.482
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	3.327004e-01	0.478
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.337242e-01	0.477
G beta:gamma signalling through PLC beta	R-HSA-418217	3.337242e-01	0.477
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.337242e-01	0.477
Presynaptic function of Kainate receptors	R-HSA-500657	3.337242e-01	0.477
Polo-like kinase mediated events	R-HSA-156711	3.337242e-01	0.477
Nephron development	R-HSA-9831926	3.337242e-01	0.477
Mismatch Repair	R-HSA-5358508	3.337242e-01	0.477
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.337242e-01	0.477
Plus-strand DNA synthesis	R-HSA-164525	3.389586e-01	0.470
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	3.389586e-01	0.470
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	3.389586e-01	0.470
Noncanonical activation of NOTCH3	R-HSA-9017802	3.389586e-01	0.470
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	3.389586e-01	0.470
Aryl hydrocarbon receptor signalling	R-HSA-8937144	3.389586e-01	0.470
Pentose phosphate pathway disease	R-HSA-6791465	3.389586e-01	0.470
CDC6 association with the ORC:origin complex	R-HSA-68689	3.389586e-01	0.470
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	3.389586e-01	0.470
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	3.389586e-01	0.470
Phosphorylation of Emi1	R-HSA-176417	3.389586e-01	0.470
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	3.389586e-01	0.470
Sodium-coupled phosphate cotransporters	R-HSA-427652	3.389586e-01	0.470
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	3.389586e-01	0.470
Regulation of CDH19 Expression and Function	R-HSA-9764302	3.389586e-01	0.470
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.389586e-01	0.470
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.389586e-01	0.470
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.412291e-01	0.467
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	3.420643e-01	0.466
Pre-NOTCH Processing in Golgi	R-HSA-1912420	3.523849e-01	0.453
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	3.523849e-01	0.453
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	3.523849e-01	0.453
O2/CO2 exchange in erythrocytes	R-HSA-1480926	3.523849e-01	0.453
Maturation of nucleoprotein	R-HSA-9694631	3.523849e-01	0.453
Signal amplification	R-HSA-392518	3.560529e-01	0.448
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	3.560529e-01	0.448
Signaling by NTRKs	R-HSA-166520	3.580835e-01	0.446
Transport to the Golgi and subsequent modification	R-HSA-948021	3.589494e-01	0.445
Extra-nuclear estrogen signaling	R-HSA-9009391	3.604849e-01	0.443
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	3.689608e-01	0.433
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.700012e-01	0.432
Signalling to ERKs	R-HSA-187687	3.700012e-01	0.432
Regulation of PD-L1(CD274) translation	R-HSA-9909620	3.708599e-01	0.431
Formation of ATP by chemiosmotic coupling	R-HSA-163210	3.708599e-01	0.431
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.708599e-01	0.431
Co-inhibition by CTLA4	R-HSA-389513	3.708599e-01	0.431
Signaling by LTK in cancer	R-HSA-9842640	3.723017e-01	0.429
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	3.723017e-01	0.429
Erythropoietin activates STAT5	R-HSA-9027283	3.723017e-01	0.429
Uncoating of the HIV Virion	R-HSA-162585	3.723017e-01	0.429
Autointegration results in viral DNA circles	R-HSA-177539	3.723017e-01	0.429
CREB phosphorylation	R-HSA-199920	3.723017e-01	0.429
Integration of viral DNA into host genomic DNA	R-HSA-175567	3.723017e-01	0.429
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.723017e-01	0.429
Nef and signal transduction	R-HSA-164944	3.723017e-01	0.429
Uptake and actions of bacterial toxins	R-HSA-5339562	3.760463e-01	0.425
Calmodulin induced events	R-HSA-111933	3.838931e-01	0.416
CaM pathway	R-HSA-111997	3.838931e-01	0.416
RET signaling	R-HSA-8853659	3.838931e-01	0.416
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	3.853281e-01	0.414
G-protein activation	R-HSA-202040	3.891204e-01	0.410
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	3.891204e-01	0.410
Lagging Strand Synthesis	R-HSA-69186	3.891204e-01	0.410
ERK/MAPK targets	R-HSA-198753	3.891204e-01	0.410
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	3.982396e-01	0.400
IFNG signaling activates MAPKs	R-HSA-9732724	4.039648e-01	0.394
SOS-mediated signalling	R-HSA-112412	4.039648e-01	0.394
DAG1 core M1 glycosylations	R-HSA-8932506	4.039648e-01	0.394
Cohesin Loading onto Chromatin	R-HSA-2470946	4.039648e-01	0.394
Recycling of eIF2:GDP	R-HSA-72731	4.039648e-01	0.394
Disinhibition of SNARE formation	R-HSA-114516	4.039648e-01	0.394
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	4.039648e-01	0.394
Activated NTRK3 signals through PI3K	R-HSA-9603381	4.039648e-01	0.394
Netrin mediated repulsion signals	R-HSA-418886	4.039648e-01	0.394
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	4.039648e-01	0.394
Displacement of DNA glycosylase by APEX1	R-HSA-110357	4.039648e-01	0.394
Glutathione synthesis and recycling	R-HSA-174403	4.071412e-01	0.390
Ribavirin ADME	R-HSA-9755088	4.071412e-01	0.390
G alpha (z) signalling events	R-HSA-418597	4.106913e-01	0.386
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	4.114479e-01	0.386
MET promotes cell motility	R-HSA-8875878	4.114479e-01	0.386
Ion homeostasis	R-HSA-5578775	4.221580e-01	0.375
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.221580e-01	0.375
Leishmania phagocytosis	R-HSA-9664417	4.244936e-01	0.372
Parasite infection	R-HSA-9664407	4.244936e-01	0.372
FCGR3A-mediated phagocytosis	R-HSA-9664422	4.244936e-01	0.372
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	4.249000e-01	0.372
Notch-HLH transcription pathway	R-HSA-350054	4.249000e-01	0.372
RAF-independent MAPK1/3 activation	R-HSA-112409	4.249000e-01	0.372
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.249000e-01	0.372
Pentose phosphate pathway	R-HSA-71336	4.250833e-01	0.372
Signaling by ALK	R-HSA-201556	4.250833e-01	0.372
Antigen processing-Cross presentation	R-HSA-1236975	4.271174e-01	0.369
Iron uptake and transport	R-HSA-917937	4.284610e-01	0.368
Late SARS-CoV-2 Infection Events	R-HSA-9772573	4.325726e-01	0.364
Reverse Transcription of HIV RNA	R-HSA-162589	4.340326e-01	0.362
Minus-strand DNA synthesis	R-HSA-164516	4.340326e-01	0.362
EGFR interacts with phospholipase C-gamma	R-HSA-212718	4.340326e-01	0.362
DAG1 core M2 glycosylations	R-HSA-8932504	4.340326e-01	0.362
Signaling by MRAS-complex mutants	R-HSA-9660537	4.340326e-01	0.362
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.340326e-01	0.362
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	4.340326e-01	0.362
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.340326e-01	0.362
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	4.340326e-01	0.362
Activated NTRK2 signals through FYN	R-HSA-9032500	4.340326e-01	0.362
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.340326e-01	0.362
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	4.386073e-01	0.358
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	4.386073e-01	0.358
Generation of second messenger molecules	R-HSA-202433	4.386073e-01	0.358
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.423774e-01	0.354
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	4.423774e-01	0.354
Extension of Telomeres	R-HSA-180786	4.561967e-01	0.341
Thromboxane signalling through TP receptor	R-HSA-428930	4.595567e-01	0.338
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	4.595567e-01	0.338
ARMS-mediated activation	R-HSA-170984	4.625853e-01	0.335
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.625853e-01	0.335
AKT phosphorylates targets in the nucleus	R-HSA-198693	4.625853e-01	0.335
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.625853e-01	0.335
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.625853e-01	0.335
Unwinding of DNA	R-HSA-176974	4.625853e-01	0.335
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.625853e-01	0.335
p75NTR regulates axonogenesis	R-HSA-193697	4.625853e-01	0.335
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.625853e-01	0.335
Regulation of signaling by NODAL	R-HSA-1433617	4.625853e-01	0.335
WNT mediated activation of DVL	R-HSA-201688	4.625853e-01	0.335
MASTL Facilitates Mitotic Progression	R-HSA-2465910	4.625853e-01	0.335
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	4.625853e-01	0.335
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	4.625853e-01	0.335
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	4.625853e-01	0.335
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.673972e-01	0.330
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.673972e-01	0.330
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.673972e-01	0.330
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.673972e-01	0.330
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.673972e-01	0.330
SWI/SNF chromatin remodelers	R-HSA-9932451	4.764234e-01	0.322
ATP-dependent chromatin remodelers	R-HSA-9932444	4.764234e-01	0.322
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	4.764234e-01	0.322
Activation of G protein gated Potassium channels	R-HSA-1296041	4.764234e-01	0.322
G protein gated Potassium channels	R-HSA-1296059	4.764234e-01	0.322
TGFBR3 expression	R-HSA-9839394	4.764234e-01	0.322
Laminin interactions	R-HSA-3000157	4.764234e-01	0.322
Neddylation	R-HSA-8951664	4.776628e-01	0.321
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.783993e-01	0.320
Ca-dependent events	R-HSA-111996	4.783993e-01	0.320
Formation of paraxial mesoderm	R-HSA-9793380	4.785130e-01	0.320
SLC transporter disorders	R-HSA-5619102	4.876772e-01	0.312
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.892548e-01	0.310
NCAM signaling for neurite out-growth	R-HSA-375165	4.895379e-01	0.310
Heme signaling	R-HSA-9707616	4.895379e-01	0.310
Binding and entry of HIV virion	R-HSA-173107	4.896992e-01	0.310
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.896992e-01	0.310
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.896992e-01	0.310
PI3K/AKT activation	R-HSA-198203	4.896992e-01	0.310
EGFR Transactivation by Gastrin	R-HSA-2179392	4.896992e-01	0.310
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.896992e-01	0.310
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.896992e-01	0.310
Signal attenuation	R-HSA-74749	4.896992e-01	0.310
Regulation of CDH11 function	R-HSA-9762292	4.896992e-01	0.310
2-LTR circle formation	R-HSA-164843	4.896992e-01	0.310
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	4.896992e-01	0.310
Sperm Motility And Taxes	R-HSA-1300642	4.896992e-01	0.310
Metal sequestration by antimicrobial proteins	R-HSA-6799990	4.896992e-01	0.310
Signaling by Leptin	R-HSA-2586552	4.896992e-01	0.310
Signaling by SCF-KIT	R-HSA-1433557	4.913703e-01	0.309
TP53 Regulates Metabolic Genes	R-HSA-5628897	4.928817e-01	0.307
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	4.929654e-01	0.307
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.929654e-01	0.307
TRP channels	R-HSA-3295583	4.929654e-01	0.307
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.091725e-01	0.293
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	5.091725e-01	0.293
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	5.091725e-01	0.293
RNA Polymerase I Transcription Termination	R-HSA-73863	5.091725e-01	0.293
CD28 dependent PI3K/Akt signaling	R-HSA-389357	5.091725e-01	0.293
Cristae formation	R-HSA-8949613	5.091725e-01	0.293
tRNA processing	R-HSA-72306	5.144482e-01	0.289
DAG1 core M3 glycosylations	R-HSA-8932505	5.154467e-01	0.288
Signaling by APC mutants	R-HSA-4839744	5.154467e-01	0.288
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	5.154467e-01	0.288
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	5.154467e-01	0.288
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	5.154467e-01	0.288
vRNP Assembly	R-HSA-192905	5.154467e-01	0.288
Bicarbonate transporters	R-HSA-425381	5.154467e-01	0.288
Regulation of localization of FOXO transcription factors	R-HSA-9614399	5.154467e-01	0.288
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	5.154467e-01	0.288
CD163 mediating an anti-inflammatory response	R-HSA-9662834	5.154467e-01	0.288
Interleukin-2 signaling	R-HSA-9020558	5.154467e-01	0.288
Dissolution of Fibrin Clot	R-HSA-75205	5.154467e-01	0.288
DAG and IP3 signaling	R-HSA-1489509	5.168219e-01	0.287
Interleukin-1 family signaling	R-HSA-446652	5.174811e-01	0.286
Protein localization	R-HSA-9609507	5.244608e-01	0.280
PI3K/AKT Signaling in Cancer	R-HSA-2219528	5.249233e-01	0.280
HIV elongation arrest and recovery	R-HSA-167287	5.250365e-01	0.280
Pausing and recovery of HIV elongation	R-HSA-167290	5.250365e-01	0.280
Telomere Extension By Telomerase	R-HSA-171319	5.250365e-01	0.280
Phase 0 - rapid depolarisation	R-HSA-5576892	5.250365e-01	0.280
Activation of kainate receptors upon glutamate binding	R-HSA-451326	5.250365e-01	0.280
Signaling by TGFBR3	R-HSA-9839373	5.292880e-01	0.276
Synthesis of diphthamide-EEF2	R-HSA-5358493	5.398966e-01	0.268
Signaling by GSK3beta mutants	R-HSA-5339716	5.398966e-01	0.268
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.398966e-01	0.268
Mitotic Telophase/Cytokinesis	R-HSA-68884	5.398966e-01	0.268
Plasmalogen biosynthesis	R-HSA-75896	5.398966e-01	0.268
Signaling by AMER1 mutants	R-HSA-4839748	5.398966e-01	0.268
Signaling by AXIN mutants	R-HSA-4839735	5.398966e-01	0.268
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	5.398966e-01	0.268
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	5.398966e-01	0.268
Cytochrome c-mediated apoptotic response	R-HSA-111461	5.398966e-01	0.268
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.405506e-01	0.267
Platelet calcium homeostasis	R-HSA-418360	5.405506e-01	0.267
Glucagon-type ligand receptors	R-HSA-420092	5.405506e-01	0.267
MITF-M-regulated melanocyte development	R-HSA-9730414	5.453220e-01	0.263
Transcription of the HIV genome	R-HSA-167172	5.534601e-01	0.257
Activation of the pre-replicative complex	R-HSA-68962	5.557099e-01	0.255
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	5.557099e-01	0.255
Activation of BH3-only proteins	R-HSA-114452	5.557099e-01	0.255
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	5.557099e-01	0.255
Innate Immune System	R-HSA-168249	5.595868e-01	0.252
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.631141e-01	0.249
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.631141e-01	0.249
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	5.631141e-01	0.249
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	5.631141e-01	0.249
Scavenging by Class F Receptors	R-HSA-3000484	5.631141e-01	0.249
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	5.631141e-01	0.249
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	5.631141e-01	0.249
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	5.631141e-01	0.249
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	5.631141e-01	0.249
RUNX3 regulates p14-ARF	R-HSA-8951936	5.631141e-01	0.249
GRB2 events in EGFR signaling	R-HSA-179812	5.631141e-01	0.249
Serotonin clearance from the synaptic cleft	R-HSA-380615	5.631141e-01	0.249
Polymerase switching	R-HSA-69091	5.631141e-01	0.249
Regulation of IFNG signaling	R-HSA-877312	5.631141e-01	0.249
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.631141e-01	0.249
Role of second messengers in netrin-1 signaling	R-HSA-418890	5.631141e-01	0.249
Leading Strand Synthesis	R-HSA-69109	5.631141e-01	0.249
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	5.705106e-01	0.244
Molecules associated with elastic fibres	R-HSA-2129379	5.705106e-01	0.244
Formation of the cornified envelope	R-HSA-6809371	5.714553e-01	0.243
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	5.837792e-01	0.234
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	5.849503e-01	0.233
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.851615e-01	0.233
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.851615e-01	0.233
Frs2-mediated activation	R-HSA-170968	5.851615e-01	0.233
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.851615e-01	0.233
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.851615e-01	0.233
CD28 dependent Vav1 pathway	R-HSA-389359	5.851615e-01	0.233
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	5.851615e-01	0.233
Interleukin-6 signaling	R-HSA-1059683	5.851615e-01	0.233
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.851615e-01	0.233
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	5.936172e-01	0.226
FGFR1 mutant receptor activation	R-HSA-1839124	5.990278e-01	0.223
FCERI mediated NF-kB activation	R-HSA-2871837	5.996566e-01	0.222
Formation of RNA Pol II elongation complex	R-HSA-112382	6.000976e-01	0.222
Removal of the Flap Intermediate	R-HSA-69166	6.060974e-01	0.217
Retrograde neurotrophin signalling	R-HSA-177504	6.060974e-01	0.217
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.060974e-01	0.217
Respiratory syncytial virus genome transcription	R-HSA-9828642	6.060974e-01	0.217
Malate-aspartate shuttle	R-HSA-9856872	6.060974e-01	0.217
Non-canonical inflammasome activation	R-HSA-9686114	6.060974e-01	0.217
Zinc transporters	R-HSA-435354	6.060974e-01	0.217
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	6.060974e-01	0.217
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.072686e-01	0.217
RNA Polymerase II Transcription Elongation	R-HSA-75955	6.111967e-01	0.214
Effects of PIP2 hydrolysis	R-HSA-114508	6.127428e-01	0.213
Glucagon signaling in metabolic regulation	R-HSA-163359	6.127428e-01	0.213
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.127428e-01	0.213
RNA Polymerase II Pre-transcription Events	R-HSA-674695	6.128735e-01	0.213
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	6.157781e-01	0.211
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	6.222871e-01	0.206
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.228798e-01	0.206
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	6.241785e-01	0.205
Erythropoietin activates RAS	R-HSA-9027284	6.259780e-01	0.203
SHC1 events in EGFR signaling	R-HSA-180336	6.259780e-01	0.203
Beta-catenin phosphorylation cascade	R-HSA-196299	6.259780e-01	0.203
p38MAPK events	R-HSA-171007	6.259780e-01	0.203
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.259780e-01	0.203
Other semaphorin interactions	R-HSA-416700	6.259780e-01	0.203
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	6.260960e-01	0.203
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	6.260960e-01	0.203
eNOS activation	R-HSA-203615	6.260960e-01	0.203
Ion channel transport	R-HSA-983712	6.341514e-01	0.198
Adipogenesis	R-HSA-9843745	6.369309e-01	0.196
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	6.390891e-01	0.194
NRAGE signals death through JNK	R-HSA-193648	6.432373e-01	0.192
Defective GALNT12 causes CRCS1	R-HSA-5083636	6.448563e-01	0.191
Defective GALNT3 causes HFTC	R-HSA-5083625	6.448563e-01	0.191
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	6.448563e-01	0.191
Atorvastatin ADME	R-HSA-9754706	6.448563e-01	0.191
Fructose catabolism	R-HSA-70350	6.448563e-01	0.191
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.448563e-01	0.191
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.448563e-01	0.191
Activation of SMO	R-HSA-5635838	6.448563e-01	0.191
Attachment and Entry	R-HSA-9678110	6.448563e-01	0.191
GPVI-mediated activation cascade	R-HSA-114604	6.517243e-01	0.186
Dectin-2 family	R-HSA-5621480	6.534941e-01	0.185
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	6.534941e-01	0.185
Interferon alpha/beta signaling	R-HSA-909733	6.565516e-01	0.183
Fibronectin matrix formation	R-HSA-1566977	6.627829e-01	0.179
Transcriptional regulation of testis differentiation	R-HSA-9690406	6.627829e-01	0.179
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.627829e-01	0.179
Galactose catabolism	R-HSA-70370	6.627829e-01	0.179
Biosynthesis of maresin-like SPMs	R-HSA-9027307	6.627829e-01	0.179
Acetylcholine regulates insulin secretion	R-HSA-399997	6.627829e-01	0.179
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.627829e-01	0.179
Mitochondrial biogenesis	R-HSA-1592230	6.708359e-01	0.173
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	6.759339e-01	0.170
Elastic fibre formation	R-HSA-1566948	6.759339e-01	0.170
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.759339e-01	0.170
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.798056e-01	0.168
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	6.798056e-01	0.168
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	6.798056e-01	0.168
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.798056e-01	0.168
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	6.798056e-01	0.168
Uptake and function of anthrax toxins	R-HSA-5210891	6.798056e-01	0.168
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.798056e-01	0.168
RAB geranylgeranylation	R-HSA-8873719	6.829862e-01	0.166
tRNA Aminoacylation	R-HSA-379724	6.829862e-01	0.166
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	6.875161e-01	0.163
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	6.875161e-01	0.163
PLC beta mediated events	R-HSA-112043	6.923913e-01	0.160
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	6.958374e-01	0.157
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	6.959700e-01	0.157
Apoptotic factor-mediated response	R-HSA-111471	6.959700e-01	0.157
Infection with Mycobacterium tuberculosis	R-HSA-9635486	6.982486e-01	0.156
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	6.987558e-01	0.156
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	6.987558e-01	0.156
HIV Transcription Elongation	R-HSA-167169	6.987558e-01	0.156
Mitochondrial tRNA aminoacylation	R-HSA-379726	6.987558e-01	0.156
Mitochondrial protein import	R-HSA-1268020	7.015846e-01	0.154
Signaling by PDGF	R-HSA-186797	7.015846e-01	0.154
Opioid Signalling	R-HSA-111885	7.089950e-01	0.149
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	7.096581e-01	0.149
Transcriptional Regulation by VENTX	R-HSA-8853884	7.096581e-01	0.149
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.113193e-01	0.148
Germ layer formation at gastrulation	R-HSA-9754189	7.113193e-01	0.148
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	7.113193e-01	0.148
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	7.113193e-01	0.148
The NLRP3 inflammasome	R-HSA-844456	7.113193e-01	0.148
Rap1 signalling	R-HSA-392517	7.113193e-01	0.148
STING mediated induction of host immune responses	R-HSA-1834941	7.113193e-01	0.148
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	7.113193e-01	0.148
Other interleukin signaling	R-HSA-449836	7.113193e-01	0.148
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.113193e-01	0.148
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	7.113264e-01	0.148
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	7.113677e-01	0.148
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.159580e-01	0.145
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.202285e-01	0.143
Signaling by FGFR1 in disease	R-HSA-5655302	7.202285e-01	0.143
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	7.258945e-01	0.139
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.258945e-01	0.139
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.258945e-01	0.139
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.258945e-01	0.139
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.258945e-01	0.139
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.258945e-01	0.139
Wax and plasmalogen biosynthesis	R-HSA-8848584	7.258945e-01	0.139
Signaling by NODAL	R-HSA-1181150	7.258945e-01	0.139
Creatine metabolism	R-HSA-71288	7.258945e-01	0.139
Cytosolic tRNA aminoacylation	R-HSA-379716	7.304725e-01	0.136
Activation of GABAB receptors	R-HSA-991365	7.304725e-01	0.136
GABA B receptor activation	R-HSA-977444	7.304725e-01	0.136
Metabolism of amino acids and derivatives	R-HSA-71291	7.305443e-01	0.136
Matriglycan biosynthesis on DAG1	R-HSA-9939291	7.397347e-01	0.131
Signalling to RAS	R-HSA-167044	7.397347e-01	0.131
Zygotic genome activation (ZGA)	R-HSA-9819196	7.397347e-01	0.131
G-protein mediated events	R-HSA-112040	7.444182e-01	0.128
Kidney development	R-HSA-9830369	7.444182e-01	0.128
Proteasome assembly	R-HSA-9907900	7.500061e-01	0.125
Amine ligand-binding receptors	R-HSA-375280	7.500061e-01	0.125
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	7.528769e-01	0.123
Signaling by NTRK3 (TRKC)	R-HSA-9034015	7.528769e-01	0.123
Attachment and Entry	R-HSA-9694614	7.528769e-01	0.123
Signaling by PDGFR in disease	R-HSA-9671555	7.528769e-01	0.123
Toll-like Receptor Cascades	R-HSA-168898	7.573713e-01	0.121
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.593082e-01	0.120
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.593082e-01	0.120
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.593082e-01	0.120
Gastrulation	R-HSA-9758941	7.597223e-01	0.119
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.653562e-01	0.116
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.653562e-01	0.116
Signaling by KIT in disease	R-HSA-9669938	7.653562e-01	0.116
LDL clearance	R-HSA-8964038	7.653562e-01	0.116
Fructose metabolism	R-HSA-5652084	7.653562e-01	0.116
Ethanol oxidation	R-HSA-71384	7.653562e-01	0.116
Diseases of DNA repair	R-HSA-9675135	7.683092e-01	0.114
Class I MHC mediated antigen processing & presentation	R-HSA-983169	7.697226e-01	0.114
ECM proteoglycans	R-HSA-3000178	7.750365e-01	0.111
Synthesis of PC	R-HSA-1483191	7.770157e-01	0.110
Termination of O-glycan biosynthesis	R-HSA-977068	7.772060e-01	0.109
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.772060e-01	0.109
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.772060e-01	0.109
Formation of the ureteric bud	R-HSA-9830674	7.772060e-01	0.109
Biosynthesis of maresins	R-HSA-9018682	7.772060e-01	0.109
Growth hormone receptor signaling	R-HSA-982772	7.772060e-01	0.109
NGF-stimulated transcription	R-HSA-9031628	7.854346e-01	0.105
Interleukin-6 family signaling	R-HSA-6783589	7.884581e-01	0.103
Ca2+ pathway	R-HSA-4086398	7.891815e-01	0.103
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	7.991425e-01	0.097
Tight junction interactions	R-HSA-420029	7.991425e-01	0.097
Acyl chain remodelling of PS	R-HSA-1482801	7.991425e-01	0.097
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.991425e-01	0.097
Hyaluronan degradation	R-HSA-2160916	7.991425e-01	0.097
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.991425e-01	0.097
Fertilization	R-HSA-1187000	7.991425e-01	0.097
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.991425e-01	0.097
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.991425e-01	0.097
Azathioprine ADME	R-HSA-9748787	8.014367e-01	0.096
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.031836e-01	0.095
Potassium Channels	R-HSA-1296071	8.031836e-01	0.095
Rab regulation of trafficking	R-HSA-9007101	8.067675e-01	0.093
Signaling by FLT3 fusion proteins	R-HSA-9703465	8.092880e-01	0.092
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	8.092880e-01	0.092
Urea cycle	R-HSA-70635	8.092880e-01	0.092
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.092880e-01	0.092
Regulation of insulin secretion	R-HSA-422356	8.144607e-01	0.089
Neurexins and neuroligins	R-HSA-6794361	8.163706e-01	0.088
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.189215e-01	0.087
Maturation of hRSV A proteins	R-HSA-9828806	8.189215e-01	0.087
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.189215e-01	0.087
Nuclear Receptor transcription pathway	R-HSA-383280	8.213312e-01	0.085
Amino acids regulate mTORC1	R-HSA-9639288	8.234542e-01	0.084
Nucleotide biosynthesis	R-HSA-8956320	8.234542e-01	0.084
Asparagine N-linked glycosylation	R-HSA-446203	8.244568e-01	0.084
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	8.272352e-01	0.082
Inflammasomes	R-HSA-622312	8.280690e-01	0.082
Prednisone ADME	R-HSA-9757110	8.280690e-01	0.082
Signaling by Erythropoietin	R-HSA-9006335	8.367549e-01	0.077
mRNA Capping	R-HSA-72086	8.367549e-01	0.077
Paracetamol ADME	R-HSA-9753281	8.368890e-01	0.077
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.385431e-01	0.076
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.432537e-01	0.074
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.450025e-01	0.073
DAP12 signaling	R-HSA-2424491	8.450025e-01	0.073
GABA synthesis, release, reuptake and degradation	R-HSA-888590	8.450025e-01	0.073
Neurotransmitter clearance	R-HSA-112311	8.450025e-01	0.073
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.450025e-01	0.073
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.450025e-01	0.073
Cytoprotection by HMOX1	R-HSA-9707564	8.492062e-01	0.071
Parasitic Infection Pathways	R-HSA-9824443	8.526754e-01	0.069
Leishmania infection	R-HSA-9658195	8.526754e-01	0.069
Platelet homeostasis	R-HSA-418346	8.588099e-01	0.066
Protein-protein interactions at synapses	R-HSA-6794362	8.592513e-01	0.066
DAG1 glycosylations	R-HSA-8931838	8.602701e-01	0.065
Signaling by WNT in cancer	R-HSA-4791275	8.602701e-01	0.065
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.602701e-01	0.065
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.610170e-01	0.065
MITF-M-dependent gene expression	R-HSA-9856651	8.655267e-01	0.063
GABA receptor activation	R-HSA-977443	8.665162e-01	0.062
Glutathione conjugation	R-HSA-156590	8.665162e-01	0.062
Metabolism of polyamines	R-HSA-351202	8.665162e-01	0.062
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	8.673309e-01	0.062
Cardiogenesis	R-HSA-9733709	8.673309e-01	0.062
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	8.673309e-01	0.062
Recycling of bile acids and salts	R-HSA-159418	8.673309e-01	0.062
Aquaporin-mediated transport	R-HSA-445717	8.718150e-01	0.060
Resolution of D-Loop Structures	R-HSA-5693537	8.740353e-01	0.058
Acyl chain remodelling of PC	R-HSA-1482788	8.740353e-01	0.058
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.740353e-01	0.058
Hyaluronan metabolism	R-HSA-2142845	8.804014e-01	0.055
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	8.804014e-01	0.055
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.804014e-01	0.055
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.818361e-01	0.055
Acyl chain remodelling of PE	R-HSA-1482839	8.864460e-01	0.052
Ion transport by P-type ATPases	R-HSA-936837	8.865705e-01	0.052
Aerobic respiration and respiratory electron transport	R-HSA-1428517	8.913105e-01	0.050
RNA Polymerase III Transcription	R-HSA-74158	8.921855e-01	0.050
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	8.921855e-01	0.050
Interferon gamma signaling	R-HSA-877300	8.947627e-01	0.048
Voltage gated Potassium channels	R-HSA-1296072	8.976353e-01	0.047
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.028098e-01	0.044
Mitochondrial protein degradation	R-HSA-9837999	9.046365e-01	0.044
COPII-mediated vesicle transport	R-HSA-204005	9.114703e-01	0.040
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.123883e-01	0.040
Interleukin-2 family signaling	R-HSA-451927	9.123883e-01	0.040
Extracellular matrix organization	R-HSA-1474244	9.163085e-01	0.038
Aflatoxin activation and detoxification	R-HSA-5423646	9.168179e-01	0.038
Post-translational protein phosphorylation	R-HSA-8957275	9.205143e-01	0.036
HIV Transcription Initiation	R-HSA-167161	9.210239e-01	0.036
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.210239e-01	0.036
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.210239e-01	0.036
Intra-Golgi traffic	R-HSA-6811438	9.210239e-01	0.036
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.210239e-01	0.036
Aspirin ADME	R-HSA-9749641	9.219057e-01	0.035
Signaling by FGFR in disease	R-HSA-1226099	9.251189e-01	0.034
G alpha (s) signalling events	R-HSA-418555	9.273199e-01	0.033
RNA Polymerase II Promoter Escape	R-HSA-73776	9.288091e-01	0.032
TBC/RABGAPs	R-HSA-8854214	9.288091e-01	0.032
DAP12 interactions	R-HSA-2172127	9.324094e-01	0.030
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.358278e-01	0.029
Integrin cell surface interactions	R-HSA-216083	9.367652e-01	0.028
Interleukin-10 signaling	R-HSA-6783783	9.367652e-01	0.028
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.390735e-01	0.027
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.390735e-01	0.027
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.390735e-01	0.027
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.421552e-01	0.026
Metal ion SLC transporters	R-HSA-425410	9.450812e-01	0.025
Cardiac conduction	R-HSA-5576891	9.455510e-01	0.024
Keratinization	R-HSA-6805567	9.468504e-01	0.024
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.476865e-01	0.023
PI3K Cascade	R-HSA-109704	9.504972e-01	0.022
Complex IV assembly	R-HSA-9864848	9.530017e-01	0.021
The phototransduction cascade	R-HSA-2514856	9.530017e-01	0.021
Metabolism of nucleotides	R-HSA-15869	9.536778e-01	0.021
FCERI mediated MAPK activation	R-HSA-2871796	9.547376e-01	0.020
Integration of energy metabolism	R-HSA-163685	9.558136e-01	0.020
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.596683e-01	0.018
Class B/2 (Secretin family receptors)	R-HSA-373080	9.638509e-01	0.016
IRS-mediated signalling	R-HSA-112399	9.655836e-01	0.015
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.673256e-01	0.014
FCGR activation	R-HSA-2029481	9.696464e-01	0.013
Leishmania parasite growth and survival	R-HSA-9664433	9.701307e-01	0.013
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.701307e-01	0.013
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.705498e-01	0.013
Collagen formation	R-HSA-1474290	9.709490e-01	0.013
IRS-related events triggered by IGF1R	R-HSA-2428928	9.720407e-01	0.012
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.745413e-01	0.011
Insulin receptor signalling cascade	R-HSA-74751	9.760760e-01	0.011
IGF1R signaling cascade	R-HSA-2428924	9.760760e-01	0.011
Xenobiotics	R-HSA-211981	9.760760e-01	0.011
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	9.772875e-01	0.010
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.784376e-01	0.009
PPARA activates gene expression	R-HSA-1989781	9.784928e-01	0.009
Cell surface interactions at the vascular wall	R-HSA-202733	9.789854e-01	0.009
G alpha (q) signalling events	R-HSA-416476	9.793416e-01	0.009
Diseases of glycosylation	R-HSA-3781865	9.794904e-01	0.009
Nicotinate metabolism	R-HSA-196807	9.795296e-01	0.009
Bacterial Infection Pathways	R-HSA-9824439	9.795433e-01	0.009
O-linked glycosylation of mucins	R-HSA-913709	9.805663e-01	0.009
Metabolism of cofactors	R-HSA-8978934	9.833723e-01	0.007
Purine catabolism	R-HSA-74259	9.842147e-01	0.007
ROS and RNS production in phagocytes	R-HSA-1222556	9.857736e-01	0.006
Bile acid and bile salt metabolism	R-HSA-194068	9.869514e-01	0.006
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.878284e-01	0.005
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.890308e-01	0.005
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.901146e-01	0.004
Role of phospholipids in phagocytosis	R-HSA-2029485	9.904885e-01	0.004
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.904885e-01	0.004
Neurotransmitter release cycle	R-HSA-112310	9.941249e-01	0.003
Drug ADME	R-HSA-9748784	9.941545e-01	0.003
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.944984e-01	0.002
Signaling by Insulin receptor	R-HSA-74752	9.949743e-01	0.002
Diseases of metabolism	R-HSA-5668914	9.963512e-01	0.002
Synthesis of bile acids and bile salts	R-HSA-192105	9.966866e-01	0.001
FOXO-mediated transcription	R-HSA-9614085	9.966866e-01	0.001
Glycerophospholipid biosynthesis	R-HSA-1483206	9.967444e-01	0.001
O-linked glycosylation	R-HSA-5173105	9.969805e-01	0.001
Antimicrobial peptides	R-HSA-6803157	9.983170e-01	0.001
Peptide ligand-binding receptors	R-HSA-375276	9.983929e-01	0.001
Nucleotide catabolism	R-HSA-8956319	9.994372e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.995366e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.995432e-01	0.000
Respiratory electron transport	R-HSA-611105	9.996013e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.996806e-01	0.000
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.997684e-01	0.000
Visual phototransduction	R-HSA-2187338	9.998121e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.998393e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999120e-01	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.999340e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.999345e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999367e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999676e-01	0.000
Phase I - Functionalization of compounds	R-HSA-211945	9.999756e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999801e-01	0.000
Transport of small molecules	R-HSA-382551	9.999829e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999839e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999894e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.999958e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999978e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.999994e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000