VRK1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O75469 S350 EPSD|PSP NR1I2 PXR LKKLQLHEEEYVLMQAISLFsPDRPGVLQHRVVDQLQEQFA
O75531 S4 GPS6|SIGNOR|EPSD|PSP BANF1 BAF BCRG1 _________________MttsQKHRDFVAEPMGEKPVGSLA
O75531 T2 GPS6|SIGNOR|EPSD|PSP BANF1 BAF BCRG1 ___________________MttsQKHRDFVAEPMGEKPVGS
O75531 T3 GPS6|SIGNOR|EPSD|PSP BANF1 BAF BCRG1 __________________MttsQKHRDFVAEPMGEKPVGSL
O75822 T33 Sugiyama EIF3J EIF3S1 PRO0391 sWDADAFsVEDPVRKVGGGGtAGGDRWEGEDEDEDVKDNWD
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04637 T18 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP TP53 P53 ___MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQ
P04792 S86 Sugiyama HSPB1 HSP27 HSP28 PAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVNHFAP
P05412 S63 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP JUN ADPVGSLKPHLRAKNsDLLtsPDVGLLKLAsPELERLIIQS
P05412 S73 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP JUN LRAKNsDLLtsPDVGLLKLAsPELERLIIQSSNGHItttPt
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P0C0S8 T121 EPSD H2AC11 H2AFP HIST1H2AG; H2AC13 H2AFC HIST1H2AI; H2AC15 H2AFD HIST1H2AK; H2AC16 H2AFI HIST1H2AL; H2AC17 H2AFN HIST1H2AM VtIAQGGVLPNIQAVLLPKKtEsHHKAKGK___________
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11586 T128 Sugiyama MTHFD1 MTHFC MTHFD SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P15336 S62 SIGNOR|EPSD|PSP ATF2 CREB2 CREBP1 LAVHKHKHEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEV
P15336 T73 GPS6|SIGNOR|EPSD|PSP ATF2 CREB2 CREBP1 LKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELAsPFE
P24752 T220 Sugiyama ACAT1 ACAT MAT TAKKLNIARNEQDAyAINsytRSKAAWEAGKFGNEVIPVtV
P27695 T97 Sugiyama APEX1 APE APE1 APEX APX HAP1 REF1 KKKGLDWVKEEAPDILCLQEtKCSENKLPAELQELPGLSHQ
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P35221 S641 Sugiyama CTNNA1 GIRDIRKAVLMIRtPEELDDsDFEtEDFDVRsRtsVQtEDD
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P38432 S184 EPSD|PSP COIL CLN80 RKNKATCGTVGDDNEEAKRKsPKKKEKCEYKKKAKNPKsPK
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P49327 S207 Sugiyama FASN FAS GINVLLKPNTSVQFLRLGMLsPEGtCKAFDtAGNGYCRSEG
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P68431 S11 GPS6|SIGNOR|ELM|iPTMNet|EPSD H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J __________MARtKQtARKstGGKAPRKQLATKAARKsAP
P68431 T4 GPS6|ELM|iPTMNet|EPSD H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J _________________MARtKQtARKstGGKAPRKQLATK
Q13769 S314 Sugiyama THOC5 C22orf19 KIAA0983 VDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQLD
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q8WU90 T348 Sugiyama ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730 sVNDIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLs
Q92993 T158 PSP KAT5 HTATIP TIP60 SCLQPNHRSTKRKVEVVsPAtPVPSETAPASVFPQNGAARR
Q99986 S376 PSP VRK1 KKRKKEIEESKEPGVEDTEWsNtQtEEAIQtRSRTRKRVQK
Q99986 T355 GPS6|EPSD|PSP VRK1 DDGKLDLsVVENGGLKAKTItKKRKKEIEESKEPGVEDTEW
Q99986 T386 PSP VRK1 KEPGVEDTEWsNtQtEEAIQtRSRTRKRVQK__________
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 9.460729e-09 8.024 1 0
Signal Transduction R-HSA-162582 1.457960e-08 7.836 0 0
EPH-Ephrin signaling R-HSA-2682334 3.317999e-07 6.479 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.468643e-07 6.460 0 0
Post NMDA receptor activation events R-HSA-438064 6.676739e-07 6.175 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.519213e-07 6.186 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.333364e-07 6.030 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.264277e-06 5.645 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.216767e-06 5.654 0 0
Cell Cycle, Mitotic R-HSA-69278 2.244249e-06 5.649 1 0
Axon guidance R-HSA-422475 1.872279e-06 5.728 0 0
Apoptotic execution phase R-HSA-75153 3.085632e-06 5.511 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.703673e-06 5.244 0 0
Signaling by ERBB2 R-HSA-1227986 6.051550e-06 5.218 0 0
Signaling by VEGF R-HSA-194138 6.987242e-06 5.156 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.694158e-06 5.114 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.202244e-06 5.086 0 0
Semaphorin interactions R-HSA-373755 9.510980e-06 5.022 0 0
Nervous system development R-HSA-9675108 9.799687e-06 5.009 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.042595e-05 4.982 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.135544e-05 4.945 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.357194e-05 4.867 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.563834e-05 4.806 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.524072e-05 4.817 0 0
PKR-mediated signaling R-HSA-9833482 2.049816e-05 4.688 0 0
Co-stimulation by CD28 R-HSA-389356 2.426254e-05 4.615 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.347913e-05 4.629 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.933546e-05 4.405 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.109940e-05 4.386 0 0
Transport of connexons to the plasma membrane R-HSA-190872 5.186902e-05 4.285 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.756274e-05 4.240 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.690363e-05 4.175 0 0
M Phase R-HSA-68886 6.588531e-05 4.181 1 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 9.898616e-05 4.004 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.217384e-04 3.915 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.345302e-04 3.871 0 0
Aggrephagy R-HSA-9646399 1.579482e-04 3.801 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.686824e-04 3.773 0 0
Apoptosis R-HSA-109581 1.894337e-04 3.723 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.136559e-04 3.670 0 0
Selective autophagy R-HSA-9663891 2.140611e-04 3.669 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.617153e-04 3.582 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.172309e-04 3.499 1 0
Sema4D in semaphorin signaling R-HSA-400685 3.181068e-04 3.497 0 0
NRAGE signals death through JNK R-HSA-193648 3.482385e-04 3.458 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.408151e-04 3.467 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.586016e-04 3.445 1 0
Mitotic Anaphase R-HSA-68882 3.390396e-04 3.470 1 0
G2/M Transition R-HSA-69275 3.540395e-04 3.451 0 0
Signaling by Interleukins R-HSA-449147 3.680569e-04 3.434 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.994039e-04 3.399 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.007376e-04 3.397 0 0
Homology Directed Repair R-HSA-5693538 4.126609e-04 3.384 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.543316e-04 3.343 0 0
Signaling by ALK in cancer R-HSA-9700206 4.543316e-04 3.343 0 0
Programmed Cell Death R-HSA-5357801 4.511056e-04 3.346 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.950154e-04 3.305 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.220508e-04 3.206 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.220508e-04 3.206 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.220508e-04 3.206 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.220508e-04 3.206 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.220508e-04 3.206 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.220508e-04 3.206 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.220508e-04 3.206 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.220508e-04 3.206 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.220508e-04 3.206 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.220508e-04 3.206 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.220508e-04 3.206 0 0
Mitotic Prometaphase R-HSA-68877 5.355935e-04 3.271 0 0
Separation of Sister Chromatids R-HSA-2467813 5.863544e-04 3.232 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.177720e-04 3.209 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.336541e-04 3.273 0 0
Kinesins R-HSA-983189 5.540762e-04 3.256 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.631419e-04 3.117 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.388677e-04 3.131 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.850367e-04 3.105 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.631419e-04 3.117 0 0
Membrane Trafficking R-HSA-199991 7.514372e-04 3.124 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.747469e-04 3.058 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.933429e-04 3.049 0 0
PCP/CE pathway R-HSA-4086400 9.292858e-04 3.032 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.437302e-04 3.025 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.053648e-03 2.977 0 0
Cellular responses to stress R-HSA-2262752 1.020440e-03 2.991 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.136603e-03 2.944 0 0
Erythropoietin activates RAS R-HSA-9027284 1.169209e-03 2.932 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.217838e-03 2.914 0 0
DNA Double Strand Break Response R-HSA-5693606 1.152206e-03 2.938 0 0
Cell Cycle Checkpoints R-HSA-69620 1.230243e-03 2.910 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.205937e-03 2.919 0 0
Hemostasis R-HSA-109582 1.249648e-03 2.903 0 0
Interferon Signaling R-HSA-913531 1.324189e-03 2.878 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.559053e-03 2.807 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.490060e-03 2.827 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.559053e-03 2.807 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.559070e-03 2.807 0 0
Gap junction trafficking R-HSA-190828 1.461172e-03 2.835 0 0
Gap junction assembly R-HSA-190861 1.598326e-03 2.796 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.682134e-03 2.774 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.841508e-03 2.735 0 0
Immune System R-HSA-168256 1.981033e-03 2.703 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.012863e-03 2.696 0 0
Regulation of CDH11 function R-HSA-9762292 2.081341e-03 2.682 0 0
Myogenesis R-HSA-525793 2.147316e-03 2.668 0 0
Interleukin-12 family signaling R-HSA-447115 2.184177e-03 2.661 0 0
Hedgehog 'off' state R-HSA-5610787 2.258080e-03 2.646 0 0
G2/M Checkpoints R-HSA-69481 2.349584e-03 2.629 0 0
Autophagy R-HSA-9612973 2.376567e-03 2.624 0 0
Macroautophagy R-HSA-1632852 2.385001e-03 2.623 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.497639e-03 2.602 0 0
Neutrophil degranulation R-HSA-6798695 2.470084e-03 2.607 0 0
MAPK family signaling cascades R-HSA-5683057 2.555837e-03 2.592 0 0
Gap junction trafficking and regulation R-HSA-157858 2.561942e-03 2.591 0 0
Interleukin-12 signaling R-HSA-9020591 2.605357e-03 2.584 0 0
Cellular responses to stimuli R-HSA-8953897 2.636349e-03 2.579 0 0
Ephrin signaling R-HSA-3928664 2.666106e-03 2.574 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.324999e-03 2.478 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.324999e-03 2.478 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.324999e-03 2.478 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.324999e-03 2.478 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.789549e-03 2.421 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.789549e-03 2.421 0 0
Activation of RAC1 R-HSA-428540 3.463743e-03 2.460 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.463743e-03 2.460 0 0
DNA Repair R-HSA-73894 4.045574e-03 2.393 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.345063e-03 2.362 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 4.416900e-03 2.355 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.416900e-03 2.355 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.416900e-03 2.355 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.496340e-03 2.347 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.639376e-03 2.334 0 0
MTOR signalling R-HSA-165159 4.719029e-03 2.326 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.216970e-03 2.283 0 0
Signaling by SCF-KIT R-HSA-1433557 5.239814e-03 2.281 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.366207e-03 2.270 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.255283e-03 2.279 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.561211e-03 2.255 1 1
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.569260e-03 2.254 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.569260e-03 2.254 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.582037e-03 2.253 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.633224e-03 2.249 0 0
Vesicle-mediated transport R-HSA-5653656 5.803762e-03 2.236 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.057167e-03 2.218 0 0
Signaling by KIT in disease R-HSA-9669938 6.057167e-03 2.218 0 0
Nef and signal transduction R-HSA-164944 6.105105e-03 2.214 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.474163e-03 2.189 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.572293e-03 2.182 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 7.762834e-03 2.110 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.034022e-03 2.153 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 7.107971e-03 2.148 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.034022e-03 2.153 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.993853e-03 2.155 0 0
Developmental Biology R-HSA-1266738 7.448447e-03 2.128 0 0
Innate Immune System R-HSA-168249 7.298429e-03 2.137 0 0
Recycling pathway of L1 R-HSA-437239 7.762834e-03 2.110 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.862513e-03 2.104 0 0
Signalling to ERKs R-HSA-187687 7.862513e-03 2.104 0 0
Cell-extracellular matrix interactions R-HSA-446353 7.864273e-03 2.104 0 0
Cellular Senescence R-HSA-2559583 8.245300e-03 2.084 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.560604e-03 2.067 0 0
GPVI-mediated activation cascade R-HSA-114604 8.759003e-03 2.058 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.780063e-03 2.057 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.173496e-03 2.037 0 0
Signaling by PTK6 R-HSA-8848021 9.173496e-03 2.037 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 9.290150e-03 2.032 0 0
Mitotic Prophase R-HSA-68875 9.552643e-03 2.020 1 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.006785e-02 1.997 0 0
Cellular response to heat stress R-HSA-3371556 1.008102e-02 1.996 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.171361e-02 1.931 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.050659e-02 1.979 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.076752e-02 1.968 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.156029e-02 1.937 0 0
Signaling by ROBO receptors R-HSA-376176 1.031847e-02 1.986 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.171361e-02 1.931 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.102494e-02 1.958 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.171361e-02 1.931 0 0
Regulation of TP53 Expression R-HSA-6804754 1.173293e-02 1.931 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.173293e-02 1.931 0 0
Signaling by WNT R-HSA-195721 1.177846e-02 1.929 0 0
Host Interactions of HIV factors R-HSA-162909 1.180276e-02 1.928 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.240376e-02 1.906 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.324428e-02 1.878 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.287207e-02 1.890 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.287207e-02 1.890 0 0
Signaling by Erythropoietin R-HSA-9006335 1.473781e-02 1.832 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.475266e-02 1.831 0 0
FCERI mediated MAPK activation R-HSA-2871796 1.358038e-02 1.867 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.324428e-02 1.878 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.361681e-02 1.866 0 0
Signaling by Hippo R-HSA-2028269 1.287207e-02 1.890 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.324428e-02 1.878 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.309645e-02 1.883 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.490558e-02 1.827 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.490558e-02 1.827 0 0
Muscle contraction R-HSA-397014 1.521418e-02 1.818 0 0
Regulation of TP53 Activity R-HSA-5633007 1.530122e-02 1.815 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.555636e-02 1.808 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.635095e-02 1.786 0 0
Signaling by EGFR R-HSA-177929 1.655770e-02 1.781 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.713103e-02 1.766 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.713103e-02 1.766 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.717475e-02 1.765 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.770474e-02 1.752 0 0
Regulation of CDH1 Function R-HSA-9764561 1.784652e-02 1.748 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.785393e-02 1.748 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.983142e-02 1.703 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.983142e-02 1.703 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.955333e-02 1.709 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.955333e-02 1.709 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.955333e-02 1.709 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.955333e-02 1.709 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.217675e-02 1.654 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.217675e-02 1.654 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.217675e-02 1.654 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.871256e-02 1.728 0 0
Centrosome maturation R-HSA-380287 2.124984e-02 1.673 0 0
Signalling to RAS R-HSA-167044 2.217675e-02 1.654 0 0
RAB geranylgeranylation R-HSA-8873719 2.213367e-02 1.655 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.983142e-02 1.703 0 0
L1CAM interactions R-HSA-373760 1.850900e-02 1.733 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.226191e-02 1.652 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.226191e-02 1.652 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.226191e-02 1.652 0 0
G-protein beta:gamma signalling R-HSA-397795 2.226191e-02 1.652 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.368801e-02 1.625 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.368801e-02 1.625 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.368801e-02 1.625 0 0
Diseases of DNA repair R-HSA-9675135 2.389284e-02 1.622 0 0
Striated Muscle Contraction R-HSA-390522 2.446914e-02 1.611 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.446914e-02 1.611 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.446914e-02 1.611 0 0
Protein folding R-HSA-391251 2.486233e-02 1.604 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.500489e-02 1.602 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.500489e-02 1.602 1 1
Transmission across Chemical Synapses R-HSA-112315 2.503291e-02 1.601 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.504051e-02 1.601 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.504051e-02 1.601 0 0
G alpha (12/13) signalling events R-HSA-416482 2.549844e-02 1.593 0 0
HIV Infection R-HSA-162906 2.573780e-02 1.589 0 0
Signaling by Hedgehog R-HSA-5358351 2.614821e-02 1.583 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.625373e-02 1.581 0 0
RAF activation R-HSA-5673000 2.681236e-02 1.572 0 0
PTEN Regulation R-HSA-6807070 2.727236e-02 1.564 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.792082e-02 1.554 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.792082e-02 1.554 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.792082e-02 1.554 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.792082e-02 1.554 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.792082e-02 1.554 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.792082e-02 1.554 0 0
Signaling by LTK R-HSA-9842663 2.792082e-02 1.554 0 0
mTORC1-mediated signalling R-HSA-166208 2.804072e-02 1.552 0 0
Degradation of CDH1 R-HSA-9766229 2.995234e-02 1.524 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.077599e-02 1.512 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.128658e-02 1.505 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.128658e-02 1.505 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.252798e-02 1.488 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.252798e-02 1.488 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.841469e-02 1.416 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.948221e-02 1.404 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.948221e-02 1.404 0 0
HSF1-dependent transactivation R-HSA-3371571 3.450519e-02 1.462 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 3.954922e-02 1.403 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 3.319889e-02 1.479 0 0
Platelet degranulation R-HSA-114608 3.216765e-02 1.493 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.467969e-02 1.460 0 0
Deubiquitination R-HSA-5688426 3.379847e-02 1.471 0 0
Viral Infection Pathways R-HSA-9824446 3.627646e-02 1.440 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.474419e-02 1.459 0 0
Neurodegenerative Diseases R-HSA-8863678 3.474419e-02 1.459 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.587054e-02 1.445 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 3.962218e-02 1.402 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 3.962218e-02 1.402 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 3.962218e-02 1.402 0 0
Adaptive Immune System R-HSA-1280218 4.036017e-02 1.394 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.064005e-02 1.391 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.064005e-02 1.391 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.064005e-02 1.391 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 4.064005e-02 1.391 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.117698e-02 1.385 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 4.171371e-02 1.380 0 0
Phosphorylation of Emi1 R-HSA-176417 4.224102e-02 1.374 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.229862e-02 1.374 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.229862e-02 1.374 0 0
Metalloprotease DUBs R-HSA-5689901 4.229862e-02 1.374 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.229862e-02 1.374 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.284913e-02 1.368 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.284913e-02 1.368 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.284913e-02 1.368 0 0
p38MAPK events R-HSA-171007 4.284913e-02 1.368 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.284913e-02 1.368 0 0
Mitochondrial biogenesis R-HSA-1592230 4.319037e-02 1.365 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.383874e-02 1.358 0 0
Generation of second messenger molecules R-HSA-202433 4.383874e-02 1.358 0 0
Neuronal System R-HSA-112316 4.426520e-02 1.354 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.639597e-02 1.334 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.718422e-02 1.326 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.718422e-02 1.326 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.776285e-02 1.321 0 0
Cilium Assembly R-HSA-5617833 4.829577e-02 1.316 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 4.855125e-02 1.314 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 4.855125e-02 1.314 0 0
Killing mechanisms R-HSA-9664420 4.855125e-02 1.314 0 0
RAF/MAP kinase cascade R-HSA-5673001 4.988561e-02 1.302 0 0
Death Receptor Signaling R-HSA-73887 5.032329e-02 1.298 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.067704e-02 1.295 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.208428e-02 1.283 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.424590e-02 1.266 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.431748e-02 1.265 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.460431e-02 1.263 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.470670e-02 1.262 0 0
MHC class II antigen presentation R-HSA-2132295 5.501583e-02 1.260 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.522824e-02 1.258 0 0
Disinhibition of SNARE formation R-HSA-114516 6.265121e-02 1.203 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.265121e-02 1.203 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.386920e-02 1.132 0 0
Activation of RAS in B cells R-HSA-1169092 7.386920e-02 1.132 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.386920e-02 1.132 0 0
DAP12 signaling R-HSA-2424491 5.996055e-02 1.222 0 0
Signaling by RAS mutants R-HSA-6802949 7.035259e-02 1.153 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.035259e-02 1.153 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.035259e-02 1.153 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.035259e-02 1.153 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.098069e-02 1.149 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.098069e-02 1.149 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.982117e-02 1.223 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.456767e-02 1.190 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.612366e-02 1.180 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.772649e-02 1.169 0 0
Trafficking of AMPA receptors R-HSA-399719 6.490112e-02 1.188 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.996055e-02 1.222 0 0
Clathrin-mediated endocytosis R-HSA-8856828 6.634808e-02 1.178 0 0
Signaling by WNT in cancer R-HSA-4791275 7.004750e-02 1.155 0 0
TCR signaling R-HSA-202403 6.302284e-02 1.201 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.941151e-02 1.226 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.378611e-02 1.195 0 0
DAG and IP3 signaling R-HSA-1489509 6.612366e-02 1.180 0 0
Somitogenesis R-HSA-9824272 6.612366e-02 1.180 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.812122e-02 1.236 0 0
Activation of BH3-only proteins R-HSA-114452 5.996055e-02 1.222 0 0
Cell junction organization R-HSA-446728 6.299604e-02 1.201 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.226590e-02 1.141 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.412334e-02 1.193 0 0
TBC/RABGAPs R-HSA-8854214 5.810556e-02 1.236 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.265121e-02 1.203 0 0
Downstream signal transduction R-HSA-186763 6.490112e-02 1.188 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.256120e-02 1.139 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.472699e-02 1.127 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.472699e-02 1.127 0 0
IGF1R signaling cascade R-HSA-2428924 7.474607e-02 1.126 0 0
Regulation of signaling by CBL R-HSA-912631 7.477503e-02 1.126 0 0
Rap1 signalling R-HSA-392517 7.477503e-02 1.126 0 0
Maturation of nucleoprotein R-HSA-9694631 7.477503e-02 1.126 0 0
mRNA Splicing R-HSA-72172 7.526717e-02 1.123 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.539682e-02 1.123 0 0
Integrin signaling R-HSA-354192 7.539682e-02 1.123 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 7.539682e-02 1.123 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.539682e-02 1.123 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.574304e-02 1.121 0 0
Reproduction R-HSA-1474165 7.644443e-02 1.117 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.718599e-02 1.112 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 7.767675e-02 1.110 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 7.767675e-02 1.110 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 7.767675e-02 1.110 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 7.767675e-02 1.110 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 7.767675e-02 1.110 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.862305e-02 1.104 0 0
Intraflagellar transport R-HSA-5620924 7.924578e-02 1.101 0 0
Gluconeogenesis R-HSA-70263 7.924578e-02 1.101 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.928289e-02 1.101 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.094583e-02 1.092 0 0
Circadian clock R-HSA-9909396 8.182399e-02 1.087 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.213359e-02 1.085 0 0
Formation of definitive endoderm R-HSA-9823730 8.213359e-02 1.085 0 0
Signal transduction by L1 R-HSA-445144 8.213359e-02 1.085 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.213359e-02 1.085 0 0
AURKA Activation by TPX2 R-HSA-8854518 8.261115e-02 1.083 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 1.142257e-01 0.942 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 1.142257e-01 0.942 0 0
Lipophagy R-HSA-9613354 8.567023e-02 1.067 0 0
Binding and entry of HIV virion R-HSA-173107 9.799067e-02 1.009 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 9.799067e-02 1.009 0 0
Folding of actin by CCT/TriC R-HSA-390450 9.799067e-02 1.009 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 9.799067e-02 1.009 0 0
Signaling by APC mutants R-HSA-4839744 1.107710e-01 0.956 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.107710e-01 0.956 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.107710e-01 0.956 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.107710e-01 0.956 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.239555e-01 0.907 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.979022e-02 1.047 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.773249e-02 1.010 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.773249e-02 1.010 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 1.144224e-01 0.941 0 0
Thromboxane signalling through TP receptor R-HSA-428930 1.231436e-01 0.910 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 1.231436e-01 0.910 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.669089e-02 1.062 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.875308e-02 1.005 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.147862e-01 0.940 0 0
Amplification of signal from the kinetochores R-HSA-141424 9.030467e-02 1.044 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 9.030467e-02 1.044 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.484341e-02 1.071 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.102703e-01 0.958 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.135928e-01 0.945 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.041924e-01 0.982 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.041924e-01 0.982 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.050614e-01 0.979 0 0
Meiosis R-HSA-1500620 8.657641e-02 1.063 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.979022e-02 1.047 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.262807e-02 1.033 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.059476e-01 0.975 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.088299e-01 0.963 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.229290e-01 0.910 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.262807e-02 1.033 0 0
Signaling by NOTCH3 R-HSA-9012852 1.147862e-01 0.940 0 0
Meiotic recombination R-HSA-912446 9.365441e-02 1.028 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 9.799067e-02 1.009 0 0
Hedgehog 'on' state R-HSA-5632684 1.041924e-01 0.982 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.158436e-02 1.038 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.080334e-01 0.966 0 0
Protein localization R-HSA-9609507 9.133836e-02 1.039 0 0
Stabilization of p53 R-HSA-69541 1.182082e-01 0.927 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.966042e-02 1.001 0 0
Calmodulin induced events R-HSA-111933 9.875308e-02 1.005 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.142257e-01 0.942 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 8.567023e-02 1.067 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 9.799067e-02 1.009 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.239555e-01 0.907 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.239555e-01 0.907 0 0
Signaling by AXIN mutants R-HSA-4839735 1.239555e-01 0.907 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.239555e-01 0.907 0 0
CaM pathway R-HSA-111997 9.875308e-02 1.005 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.875308e-02 1.005 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.567023e-02 1.067 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 9.773249e-02 1.010 0 0
Smooth Muscle Contraction R-HSA-445355 1.039530e-01 0.983 0 0
ESR-mediated signaling R-HSA-8939211 1.035972e-01 0.985 0 0
Adherens junctions interactions R-HSA-418990 1.079183e-01 0.967 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 9.423952e-02 1.026 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 9.423952e-02 1.026 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.142257e-01 0.942 0 0
GP1b-IX-V activation signalling R-HSA-430116 8.567023e-02 1.067 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.059476e-01 0.975 0 0
Basigin interactions R-HSA-210991 8.979022e-02 1.047 0 0
Integration of provirus R-HSA-162592 1.239555e-01 0.907 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.817632e-02 1.055 0 0
Glycolysis R-HSA-70171 8.484341e-02 1.071 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 8.567023e-02 1.067 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 9.799067e-02 1.009 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 9.773249e-02 1.010 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.144224e-01 0.941 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.144224e-01 0.941 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.319595e-02 1.080 0 0
Prostanoid ligand receptors R-HSA-391908 1.107710e-01 0.956 0 0
Stimuli-sensing channels R-HSA-2672351 1.175169e-01 0.930 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.669089e-02 1.062 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.773249e-02 1.010 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.088299e-01 0.963 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 8.567023e-02 1.067 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.107710e-01 0.956 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.773249e-02 1.010 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.966042e-02 1.001 0 0
G1/S Transition R-HSA-69206 1.187654e-01 0.925 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.331433e-02 1.079 0 0
PECAM1 interactions R-HSA-210990 1.107710e-01 0.956 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.107710e-01 0.956 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.932219e-02 1.003 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.203973e-01 0.919 0 0
Interleukin-2 signaling R-HSA-9020558 1.107710e-01 0.956 0 0
Attenuation phase R-HSA-3371568 1.250364e-01 0.903 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.250364e-01 0.903 0 0
Interleukin-2 family signaling R-HSA-451927 1.250364e-01 0.903 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.319948e-01 0.879 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 1.319948e-01 0.879 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.320272e-01 0.879 0 0
FLT3 Signaling R-HSA-9607240 1.320272e-01 0.879 0 0
Long-term potentiation R-HSA-9620244 1.320978e-01 0.879 0 0
HDMs demethylate histones R-HSA-3214842 1.320978e-01 0.879 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.323761e-01 0.878 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.329601e-01 0.876 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.374922e-01 0.862 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.374922e-01 0.862 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.374922e-01 0.862 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.374922e-01 0.862 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.374922e-01 0.862 0 0
MET activates RAS signaling R-HSA-8851805 1.374922e-01 0.862 0 0
OAS antiviral response R-HSA-8983711 1.374922e-01 0.862 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.391750e-01 0.856 0 0
Intra-Golgi traffic R-HSA-6811438 1.391750e-01 0.856 0 0
S Phase R-HSA-69242 1.403394e-01 0.853 0 0
Signaling by NTRKs R-HSA-166520 1.403394e-01 0.853 0 0
Cell-Cell communication R-HSA-1500931 1.421344e-01 0.847 0 0
Ion channel transport R-HSA-983712 1.422685e-01 0.847 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.440736e-01 0.841 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.464739e-01 0.834 0 0
Ca-dependent events R-HSA-111996 1.464739e-01 0.834 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.493284e-01 0.826 0 0
DSCAM interactions R-HSA-376172 1.493284e-01 0.826 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.493284e-01 0.826 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 1.493284e-01 0.826 0 0
Axonal growth stimulation R-HSA-209563 1.830420e-01 0.737 0 0
Classical Kir channels R-HSA-1296053 1.830420e-01 0.737 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.830420e-01 0.737 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.830420e-01 0.737 0 0
Invadopodia formation R-HSA-8941237 1.830420e-01 0.737 0 0
NADE modulates death signalling R-HSA-205025 2.154215e-01 0.667 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.154215e-01 0.667 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 2.154215e-01 0.667 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.154215e-01 0.667 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.465196e-01 0.608 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 2.465196e-01 0.608 0 0
Plus-strand DNA synthesis R-HSA-164525 2.763869e-01 0.558 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.763869e-01 0.558 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.763869e-01 0.558 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.763869e-01 0.558 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.763869e-01 0.558 0 0
Signaling by RNF43 mutants R-HSA-5340588 2.763869e-01 0.558 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 2.763869e-01 0.558 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.513327e-01 0.820 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.654317e-01 0.781 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.942398e-01 0.712 0 0
Phosphorylation of the APC/C R-HSA-176412 1.942398e-01 0.712 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.088732e-01 0.680 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.088732e-01 0.680 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.088732e-01 0.680 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.088732e-01 0.680 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 1.506506e-01 0.822 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.236135e-01 0.651 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.384293e-01 0.623 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.699725e-01 0.770 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.798882e-01 0.745 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.532916e-01 0.596 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.899561e-01 0.721 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.899561e-01 0.721 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.899561e-01 0.721 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.104964e-01 0.677 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.830500e-01 0.548 0 0
Dual Incision in GG-NER R-HSA-5696400 2.314920e-01 0.635 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.421300e-01 0.616 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.421300e-01 0.616 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.095738e-01 0.679 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.264261e-01 0.645 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.349789e-01 0.629 0 0
Translation initiation complex formation R-HSA-72649 2.436077e-01 0.613 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.610685e-01 0.583 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.157983e-01 0.666 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.605024e-01 0.584 0 0
EGFR downregulation R-HSA-182971 1.899561e-01 0.721 0 0
Ribosome-associated quality control R-HSA-9948299 2.929037e-01 0.533 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.942398e-01 0.712 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.528456e-01 0.597 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.566087e-01 0.805 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.605024e-01 0.584 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 2.472676e-01 0.607 0 0
GAB1 signalosome R-HSA-180292 2.384293e-01 0.623 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.465196e-01 0.608 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.942398e-01 0.712 0 0
Regulation of Apoptosis R-HSA-169911 2.421300e-01 0.616 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.962618e-01 0.528 0 0
Pyroptosis R-HSA-5620971 1.602222e-01 0.795 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.605757e-01 0.794 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.605757e-01 0.794 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.088732e-01 0.680 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.506506e-01 0.822 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.528456e-01 0.597 0 0
Degradation of DVL R-HSA-4641258 2.636275e-01 0.579 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.681734e-01 0.572 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.421300e-01 0.616 0 0
Activation of AKT2 R-HSA-165158 2.465196e-01 0.608 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.465196e-01 0.608 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.236135e-01 0.651 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.314920e-01 0.635 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.636275e-01 0.579 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.721506e-01 0.764 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.157983e-01 0.666 0 0
HCMV Early Events R-HSA-9609690 1.667582e-01 0.778 0 0
ER-Phagosome pathway R-HSA-1236974 2.084473e-01 0.681 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.513327e-01 0.820 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.107621e-01 0.676 0 0
HIV Life Cycle R-HSA-162587 2.800386e-01 0.553 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.154215e-01 0.667 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.154215e-01 0.667 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.763869e-01 0.558 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.654317e-01 0.781 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.209435e-01 0.656 0 0
HSF1 activation R-HSA-3371511 2.528456e-01 0.597 0 0
Signaling by NOTCH4 R-HSA-9013694 2.398335e-01 0.620 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.088732e-01 0.680 0 0
Developmental Cell Lineages R-HSA-9734767 1.780654e-01 0.749 0 0
Neurexins and neuroligins R-HSA-6794361 2.264261e-01 0.645 0 0
DAP12 interactions R-HSA-2172127 1.615013e-01 0.792 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 1.830420e-01 0.737 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.830420e-01 0.737 0 0
NTRK2 activates RAC1 R-HSA-9032759 2.465196e-01 0.608 0 0
Pentose phosphate pathway disease R-HSA-6791465 2.763869e-01 0.558 0 0
PDE3B signalling R-HSA-165160 2.763869e-01 0.558 0 0
Ceramide signalling R-HSA-193681 2.763869e-01 0.558 0 0
PKB-mediated events R-HSA-109703 2.763869e-01 0.558 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.513327e-01 0.820 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.236135e-01 0.651 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.012870e-01 0.696 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.012870e-01 0.696 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.636275e-01 0.579 0 0
Metabolism of non-coding RNA R-HSA-194441 2.876759e-01 0.541 0 0
snRNP Assembly R-HSA-191859 2.876759e-01 0.541 0 0
Signaling by FGFR2 R-HSA-5654738 2.852417e-01 0.545 0 0
Signaling by FGFR4 R-HSA-5654743 1.539180e-01 0.813 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.157983e-01 0.666 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.654317e-01 0.781 0 0
Polo-like kinase mediated events R-HSA-156711 2.384293e-01 0.623 0 0
Signaling by FGFR3 R-HSA-5654741 1.692175e-01 0.772 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.465196e-01 0.608 0 0
Mitochondrial protein import R-HSA-1268020 1.566087e-01 0.805 0 0
Extension of Telomeres R-HSA-180786 2.876759e-01 0.541 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.677879e-01 0.775 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.630391e-01 0.788 0 0
Signal amplification R-HSA-392518 2.314920e-01 0.635 0 0
Signaling by FGFR1 R-HSA-5654736 2.610685e-01 0.583 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.154215e-01 0.667 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.692175e-01 0.772 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.209435e-01 0.656 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.314920e-01 0.635 0 0
The NLRP3 inflammasome R-HSA-844456 2.532916e-01 0.596 0 0
Frs2-mediated activation R-HSA-170968 1.513327e-01 0.820 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.813582e-01 0.551 0 0
Regulation of KIT signaling R-HSA-1433559 1.654317e-01 0.781 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 1.770605e-01 0.752 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 1.770605e-01 0.752 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.251570e-01 0.648 0 0
Cell-cell junction organization R-HSA-421270 2.130308e-01 0.672 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 1.830420e-01 0.737 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 2.154215e-01 0.667 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.763869e-01 0.558 0 0
DCC mediated attractive signaling R-HSA-418885 1.797472e-01 0.745 0 0
Disorders of Developmental Biology R-HSA-9675151 2.088732e-01 0.680 0 0
Activation of the pre-replicative complex R-HSA-68962 1.798882e-01 0.745 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.532916e-01 0.596 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.209435e-01 0.656 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.943260e-01 0.531 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.943260e-01 0.531 0 0
Interleukin-6 signaling R-HSA-1059683 1.513327e-01 0.820 0 0
Ub-specific processing proteases R-HSA-5689880 1.599630e-01 0.796 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.692175e-01 0.772 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.797472e-01 0.745 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.797472e-01 0.745 0 0
Nuclear import of Rev protein R-HSA-180746 2.314920e-01 0.635 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.623082e-01 0.581 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.692175e-01 0.772 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.692175e-01 0.772 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.236135e-01 0.651 0 0
Prolonged ERK activation events R-HSA-169893 1.942398e-01 0.712 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 1.830420e-01 0.737 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.154215e-01 0.667 0 0
Dopamine receptors R-HSA-390651 2.154215e-01 0.667 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.465196e-01 0.608 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 2.763869e-01 0.558 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.104964e-01 0.677 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.962618e-01 0.528 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.962618e-01 0.528 0 0
Glucose metabolism R-HSA-70326 1.652443e-01 0.782 0 0
Disease R-HSA-1643685 2.308740e-01 0.637 0 0
Netrin-1 signaling R-HSA-373752 1.615013e-01 0.792 0 0
Biotin transport and metabolism R-HSA-196780 1.797472e-01 0.745 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 1.493284e-01 0.826 0 0
Interleukin-38 signaling R-HSA-9007892 2.154215e-01 0.667 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.763869e-01 0.558 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.797472e-01 0.745 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.797472e-01 0.745 0 0
Synthesis of PG R-HSA-1483148 2.088732e-01 0.680 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.744646e-01 0.562 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.853462e-01 0.545 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.107621e-01 0.676 0 0
Rab regulation of trafficking R-HSA-9007101 1.652443e-01 0.782 0 0
Inositol phosphate metabolism R-HSA-1483249 2.391557e-01 0.621 0 0
Infectious disease R-HSA-5663205 2.477499e-01 0.606 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.001631e-01 0.699 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.853931e-01 0.545 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.763869e-01 0.558 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.853462e-01 0.545 0 0
Influenza Infection R-HSA-168255 2.831777e-01 0.548 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.763869e-01 0.558 0 0
Tie2 Signaling R-HSA-210993 2.384293e-01 0.623 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.630391e-01 0.788 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.610685e-01 0.583 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.382666e-01 0.623 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.437580e-01 0.613 0 0
Signaling by PDGF R-HSA-186797 1.566087e-01 0.805 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.699725e-01 0.770 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.610685e-01 0.583 0 0
Ion homeostasis R-HSA-5578775 2.610685e-01 0.583 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.211103e-01 0.655 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 2.775526e-01 0.557 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.104964e-01 0.677 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.808559e-01 0.552 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.808559e-01 0.552 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.808559e-01 0.552 0 0
Specification of primordial germ cells R-HSA-9827857 2.236135e-01 0.651 0 0
Signaling by ALK R-HSA-201556 2.853462e-01 0.545 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.384293e-01 0.623 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.615013e-01 0.792 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.850499e-01 0.733 0 0
Translation of Structural Proteins R-HSA-9694635 2.623082e-01 0.581 0 0
Cellular response to chemical stress R-HSA-9711123 2.801519e-01 0.553 0 0
SARS-CoV Infections R-HSA-9679506 2.431895e-01 0.614 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.485234e-01 0.605 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.978984e-01 0.526 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.978984e-01 0.526 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 2.978984e-01 0.526 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.978984e-01 0.526 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.978984e-01 0.526 0 0
Metabolism of RNA R-HSA-8953854 2.998239e-01 0.523 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.007343e-01 0.522 0 0
HCMV Infection R-HSA-9609646 3.010754e-01 0.521 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 3.045616e-01 0.516 0 0
Parasite infection R-HSA-9664407 3.045616e-01 0.516 0 0
Leishmania phagocytosis R-HSA-9664417 3.045616e-01 0.516 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.050719e-01 0.516 0 0
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) R-HSA-3656244 3.050719e-01 0.516 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.050719e-01 0.516 0 0
Uncoating of the HIV Virion R-HSA-162585 3.050719e-01 0.516 0 0
Defective ST3GAL3 causes MCT12 and EIEE15 R-HSA-3656243 3.050719e-01 0.516 0 0
Defective CHST6 causes MCDC1 R-HSA-3656225 3.050719e-01 0.516 0 0
NADPH regeneration R-HSA-389542 3.050719e-01 0.516 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 3.050719e-01 0.516 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.050719e-01 0.516 0 0
Leukotriene receptors R-HSA-391906 3.050719e-01 0.516 0 0
PLC beta mediated events R-HSA-112043 3.056220e-01 0.515 0 0
MAP kinase activation R-HSA-450294 3.056220e-01 0.515 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.072014e-01 0.513 0 0
PI Metabolism R-HSA-1483255 3.085129e-01 0.511 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.126975e-01 0.505 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.126975e-01 0.505 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 3.126975e-01 0.505 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.126975e-01 0.505 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.126975e-01 0.505 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.133304e-01 0.504 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.133304e-01 0.504 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.146402e-01 0.502 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.163547e-01 0.500 0 0
MAP2K and MAPK activation R-HSA-5674135 3.181554e-01 0.497 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.181554e-01 0.497 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.181554e-01 0.497 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.181554e-01 0.497 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.181554e-01 0.497 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.181554e-01 0.497 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.197161e-01 0.495 0 0
Formation of the cornified envelope R-HSA-6809371 3.261239e-01 0.487 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.274279e-01 0.485 0 0
Growth hormone receptor signaling R-HSA-982772 3.274279e-01 0.485 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.326216e-01 0.478 0 0
Regulation of PTEN localization R-HSA-8948747 3.326216e-01 0.478 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.326216e-01 0.478 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.326216e-01 0.478 0 0
SOS-mediated signalling R-HSA-112412 3.326216e-01 0.478 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.326216e-01 0.478 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.326216e-01 0.478 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 3.326216e-01 0.478 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.326216e-01 0.478 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.326216e-01 0.478 0 0
CHL1 interactions R-HSA-447041 3.326216e-01 0.478 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.326216e-01 0.478 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.326216e-01 0.478 0 0
Insulin receptor signalling cascade R-HSA-74751 3.327389e-01 0.478 0 0
Ion transport by P-type ATPases R-HSA-936837 3.327389e-01 0.478 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.327389e-01 0.478 0 0
Leishmania infection R-HSA-9658195 3.355358e-01 0.474 0 0
Parasitic Infection Pathways R-HSA-9824443 3.355358e-01 0.474 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.366066e-01 0.473 0 0
Deadenylation of mRNA R-HSA-429947 3.420719e-01 0.466 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.420719e-01 0.466 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.420719e-01 0.466 0 0
Interleukin-6 family signaling R-HSA-6783589 3.420719e-01 0.466 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.508851e-01 0.455 0 0
G1 Phase R-HSA-69236 3.510117e-01 0.455 0 0
Cyclin D associated events in G1 R-HSA-69231 3.510117e-01 0.455 0 0
Peptide chain elongation R-HSA-156902 3.557727e-01 0.449 0 0
Diseases of programmed cell death R-HSA-9645723 3.557727e-01 0.449 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 3.566131e-01 0.448 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.566131e-01 0.448 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 3.566131e-01 0.448 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.578632e-01 0.446 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.584263e-01 0.446 0 0
Reverse Transcription of HIV RNA R-HSA-162589 3.590807e-01 0.445 0 0
Minus-strand DNA synthesis R-HSA-164516 3.590807e-01 0.445 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.590807e-01 0.445 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.590807e-01 0.445 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.590807e-01 0.445 0 0
Formation of annular gap junctions R-HSA-196025 3.590807e-01 0.445 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.590807e-01 0.445 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.590807e-01 0.445 0 0
Interleukin-9 signaling R-HSA-8985947 3.590807e-01 0.445 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.590807e-01 0.445 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.590807e-01 0.445 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.590807e-01 0.445 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.590807e-01 0.445 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.590807e-01 0.445 0 0
G-protein mediated events R-HSA-112040 3.599632e-01 0.444 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.619332e-01 0.441 0 0
Signaling by NOTCH R-HSA-157118 3.621086e-01 0.441 0 0
Gastrulation R-HSA-9758941 3.640980e-01 0.439 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.649707e-01 0.438 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.649707e-01 0.438 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.684231e-01 0.434 0 0
Regulated Necrosis R-HSA-5218859 3.690380e-01 0.433 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.690380e-01 0.433 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.710369e-01 0.431 0 0
TRP channels R-HSA-3295583 3.710369e-01 0.431 0 0
Downstream TCR signaling R-HSA-202424 3.716127e-01 0.430 0 0
Base Excision Repair R-HSA-73884 3.716127e-01 0.430 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.720850e-01 0.429 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.720850e-01 0.429 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.728260e-01 0.428 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.728260e-01 0.428 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.728260e-01 0.428 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.795349e-01 0.421 0 0
Interleukin-1 family signaling R-HSA-446652 3.822132e-01 0.418 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.823296e-01 0.418 0 0
Cardiac conduction R-HSA-5576891 3.844680e-01 0.415 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.844923e-01 0.415 0 0
Gap junction degradation R-HSA-190873 3.844923e-01 0.415 0 0
WNT mediated activation of DVL R-HSA-201688 3.844923e-01 0.415 0 0
ALK mutants bind TKIs R-HSA-9700645 3.844923e-01 0.415 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.844923e-01 0.415 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.844923e-01 0.415 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.844923e-01 0.415 0 0
Interleukin-21 signaling R-HSA-9020958 3.844923e-01 0.415 0 0
Calcineurin activates NFAT R-HSA-2025928 3.844923e-01 0.415 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.844923e-01 0.415 0 0
Interleukin-1 processing R-HSA-448706 3.844923e-01 0.415 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 3.844923e-01 0.415 0 0
Cristae formation R-HSA-8949613 3.853295e-01 0.414 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.853295e-01 0.414 0 0
Signaling by FGFR3 in disease R-HSA-5655332 3.853295e-01 0.414 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.853295e-01 0.414 0 0
Maturation of hRSV A proteins R-HSA-9828806 3.853295e-01 0.414 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.863247e-01 0.413 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.863247e-01 0.413 0 0
COPII-mediated vesicle transport R-HSA-204005 3.871585e-01 0.412 0 0
Interleukin-17 signaling R-HSA-448424 3.871585e-01 0.412 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.874541e-01 0.412 0 0
IRE1alpha activates chaperones R-HSA-381070 3.874541e-01 0.412 0 0
GPCR downstream signalling R-HSA-388396 3.929834e-01 0.406 0 0
Co-inhibition by PD-1 R-HSA-389948 3.931717e-01 0.405 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.934452e-01 0.405 0 0
GPER1 signaling R-HSA-9634597 3.944955e-01 0.404 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.953673e-01 0.403 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 3.953673e-01 0.403 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.961951e-01 0.402 0 0
Metabolism of cofactors R-HSA-8978934 3.961951e-01 0.402 0 0
Telomere Extension By Telomerase R-HSA-171319 3.994789e-01 0.399 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 3.994789e-01 0.399 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.994789e-01 0.399 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.994789e-01 0.399 0 0
Inflammasomes R-HSA-622312 3.994789e-01 0.399 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.088979e-01 0.388 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.088979e-01 0.388 0 0
2-LTR circle formation R-HSA-164843 4.088979e-01 0.388 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.088979e-01 0.388 0 0
DNA replication initiation R-HSA-68952 4.088979e-01 0.388 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 4.088979e-01 0.388 0 0
Signal attenuation R-HSA-74749 4.088979e-01 0.388 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.088979e-01 0.388 0 0
Interleukin-27 signaling R-HSA-9020956 4.088979e-01 0.388 0 0
Sperm Motility And Taxes R-HSA-1300642 4.088979e-01 0.388 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.088979e-01 0.388 0 0
Late endosomal microautophagy R-HSA-9615710 4.134739e-01 0.384 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.134739e-01 0.384 0 0
Platelet calcium homeostasis R-HSA-418360 4.134739e-01 0.384 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.134739e-01 0.384 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.141990e-01 0.383 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.147821e-01 0.382 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 4.185383e-01 0.378 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.190400e-01 0.378 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.266069e-01 0.370 0 0
Eukaryotic Translation Termination R-HSA-72764 4.268989e-01 0.370 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.273045e-01 0.369 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 4.273045e-01 0.369 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.273045e-01 0.369 0 0
Interleukin-37 signaling R-HSA-9008059 4.273045e-01 0.369 0 0
Protein ubiquitination R-HSA-8852135 4.320830e-01 0.364 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.323372e-01 0.364 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.323372e-01 0.364 0 0
vRNP Assembly R-HSA-192905 4.323372e-01 0.364 0 0
vRNA Synthesis R-HSA-192814 4.323372e-01 0.364 0 0
Synthesis of PI R-HSA-1483226 4.323372e-01 0.364 0 0
Transport of RCbl within the body R-HSA-9758890 4.323372e-01 0.364 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 4.323372e-01 0.364 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.323372e-01 0.364 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.323372e-01 0.364 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.323372e-01 0.364 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.347369e-01 0.362 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.371809e-01 0.359 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.371809e-01 0.359 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.371809e-01 0.359 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.371809e-01 0.359 0 0
Budding and maturation of HIV virion R-HSA-162588 4.409618e-01 0.356 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.409618e-01 0.356 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 4.409618e-01 0.356 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.409703e-01 0.356 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.425515e-01 0.354 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.425515e-01 0.354 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.476805e-01 0.349 0 0
Meiotic synapsis R-HSA-1221632 4.476805e-01 0.349 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.476805e-01 0.349 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.476805e-01 0.349 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.501294e-01 0.347 0 0
Signaling by FGFR R-HSA-190236 4.503399e-01 0.346 0 0
Chromatin modifying enzymes R-HSA-3247509 4.507798e-01 0.346 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.544377e-01 0.343 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.544377e-01 0.343 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.548484e-01 0.342 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.548484e-01 0.342 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 4.548484e-01 0.342 0 0
NF-kB is activated and signals survival R-HSA-209560 4.548484e-01 0.342 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.548484e-01 0.342 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.548484e-01 0.342 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.548484e-01 0.342 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.581007e-01 0.339 0 0
RNA Polymerase I Transcription R-HSA-73864 4.586169e-01 0.339 0 0
Chromosome Maintenance R-HSA-73886 4.641450e-01 0.333 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.641450e-01 0.333 0 0
Sensory processing of sound R-HSA-9659379 4.673694e-01 0.330 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.677253e-01 0.330 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.688564e-01 0.329 0 0
Selenocysteine synthesis R-HSA-2408557 4.735230e-01 0.325 0 0
Toll-like Receptor Cascades R-HSA-168898 4.759231e-01 0.322 0 0
Signaling by MET R-HSA-6806834 4.760703e-01 0.322 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.764682e-01 0.322 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.764682e-01 0.322 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.764682e-01 0.322 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.764682e-01 0.322 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.764682e-01 0.322 0 0
Regulation of IFNG signaling R-HSA-877312 4.764682e-01 0.322 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.764682e-01 0.322 0 0
Interleukin-35 Signalling R-HSA-8984722 4.764682e-01 0.322 0 0
Interleukin-15 signaling R-HSA-8983432 4.764682e-01 0.322 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 4.764682e-01 0.322 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.764682e-01 0.322 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.764682e-01 0.322 0 0
Disorders of Nervous System Development R-HSA-9697154 4.764682e-01 0.322 0 0
Pervasive developmental disorders R-HSA-9005895 4.764682e-01 0.322 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 4.764682e-01 0.322 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.786830e-01 0.320 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.808182e-01 0.318 0 0
Vpu mediated degradation of CD4 R-HSA-180534 4.808182e-01 0.318 0 0
Viral mRNA Translation R-HSA-192823 4.888027e-01 0.311 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.888363e-01 0.311 0 0
IRS-mediated signalling R-HSA-112399 4.888363e-01 0.311 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.937111e-01 0.307 0 0
Mitophagy R-HSA-5205647 4.937111e-01 0.307 0 0
eNOS activation R-HSA-203615 4.937111e-01 0.307 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 4.937111e-01 0.307 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 4.937111e-01 0.307 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 4.937111e-01 0.307 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.937111e-01 0.307 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.937111e-01 0.307 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.963831e-01 0.304 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.963831e-01 0.304 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.963831e-01 0.304 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.972319e-01 0.303 0 0
Formation of axial mesoderm R-HSA-9796292 4.972319e-01 0.303 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.972319e-01 0.303 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.972319e-01 0.303 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.987425e-01 0.302 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.987425e-01 0.302 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.987425e-01 0.302 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.988923e-01 0.302 0 0
Dual incision in TC-NER R-HSA-6782135 4.988923e-01 0.302 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.063991e-01 0.296 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.063991e-01 0.296 0 0
Oncogene Induced Senescence R-HSA-2559585 5.063991e-01 0.296 0 0
PERK regulates gene expression R-HSA-381042 5.063991e-01 0.296 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.069603e-01 0.295 0 0
Peroxisomal protein import R-HSA-9033241 5.088472e-01 0.293 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.088472e-01 0.293 0 0
Regulation of beta-cell development R-HSA-186712 5.088472e-01 0.293 0 0
Nucleotide Excision Repair R-HSA-5696398 5.114143e-01 0.291 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.171733e-01 0.286 0 0
cGMP effects R-HSA-418457 5.171733e-01 0.286 0 0
Removal of the Flap Intermediate R-HSA-69166 5.171733e-01 0.286 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.171733e-01 0.286 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.171733e-01 0.286 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.171733e-01 0.286 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.171733e-01 0.286 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 5.171733e-01 0.286 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.171733e-01 0.286 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.186967e-01 0.285 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.188612e-01 0.285 0 0
RET signaling R-HSA-8853659 5.188783e-01 0.285 0 0
Chromatin organization R-HSA-4839726 5.259888e-01 0.279 0 0
Synthesis of DNA R-HSA-69239 5.262597e-01 0.279 0 0
Gene Silencing by RNA R-HSA-211000 5.262597e-01 0.279 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.270274e-01 0.278 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.270274e-01 0.278 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.284402e-01 0.277 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.284402e-01 0.277 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.284402e-01 0.277 0 0
Voltage gated Potassium channels R-HSA-1296072 5.311453e-01 0.275 0 0
Degradation of AXIN R-HSA-4641257 5.311453e-01 0.275 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.311453e-01 0.275 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.318458e-01 0.274 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.352877e-01 0.271 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.363249e-01 0.271 0 0
p75NTR signals via NF-kB R-HSA-193639 5.363249e-01 0.271 0 0
Translesion synthesis by REV1 R-HSA-110312 5.363249e-01 0.271 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.363249e-01 0.271 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.363249e-01 0.271 0 0
Protein methylation R-HSA-8876725 5.363249e-01 0.271 0 0
DNA Damage Reversal R-HSA-73942 5.363249e-01 0.271 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.380721e-01 0.269 0 0
tRNA processing in the nucleus R-HSA-6784531 5.380721e-01 0.269 0 0
Heme signaling R-HSA-9707616 5.380721e-01 0.269 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.431973e-01 0.265 0 0
MET promotes cell motility R-HSA-8875878 5.431973e-01 0.265 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.441039e-01 0.264 0 0
Adipogenesis R-HSA-9843745 5.457916e-01 0.263 0 0
PPARA activates gene expression R-HSA-1989781 5.501828e-01 0.259 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.547180e-01 0.256 0 0
Translesion synthesis by POLI R-HSA-5656121 5.547180e-01 0.256 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 5.547180e-01 0.256 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 5.547180e-01 0.256 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.547180e-01 0.256 0 0
Activation of SMO R-HSA-5635838 5.547180e-01 0.256 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.547180e-01 0.256 0 0
Phase 4 - resting membrane potential R-HSA-5576886 5.547180e-01 0.256 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.547180e-01 0.256 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.547180e-01 0.256 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.547180e-01 0.256 0 0
Differentiation of T cells R-HSA-9945266 5.547180e-01 0.256 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.547180e-01 0.256 0 0
RAS processing R-HSA-9648002 5.550320e-01 0.256 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.550320e-01 0.256 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 5.550320e-01 0.256 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.550320e-01 0.256 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 5.550320e-01 0.256 0 0
Signaling by GPCR R-HSA-372790 5.583085e-01 0.253 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 5.622351e-01 0.250 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.666478e-01 0.247 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.666478e-01 0.247 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.666478e-01 0.247 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.666478e-01 0.247 0 0
HIV Transcription Elongation R-HSA-167169 5.666478e-01 0.247 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 5.666478e-01 0.247 0 0
Glycogen metabolism R-HSA-8982491 5.666478e-01 0.247 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.666478e-01 0.247 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.675246e-01 0.246 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.695399e-01 0.244 0 0
Translesion synthesis by POLK R-HSA-5655862 5.723826e-01 0.242 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.723826e-01 0.242 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.723826e-01 0.242 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 5.723826e-01 0.242 0 0
Scavenging by Class B Receptors R-HSA-3000471 5.723826e-01 0.242 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.723826e-01 0.242 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 5.723826e-01 0.242 0 0
tRNA modification in the mitochondrion R-HSA-6787450 5.723826e-01 0.242 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.754599e-01 0.240 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.765538e-01 0.239 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.780433e-01 0.238 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.780433e-01 0.238 0 0
Maturation of spike protein R-HSA-9694548 5.780433e-01 0.238 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.780433e-01 0.238 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 5.780433e-01 0.238 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.780433e-01 0.238 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.780433e-01 0.238 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.892177e-01 0.230 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.893474e-01 0.230 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 5.893474e-01 0.230 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.893474e-01 0.230 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 5.893474e-01 0.230 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.893474e-01 0.230 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.893474e-01 0.230 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.893474e-01 0.230 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.893474e-01 0.230 0 0
Sulfide oxidation to sulfate R-HSA-1614517 5.893474e-01 0.230 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.893474e-01 0.230 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.893474e-01 0.230 0 0
Signaling by Insulin receptor R-HSA-74752 5.909684e-01 0.228 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.934034e-01 0.227 0 0
Interferon alpha/beta signaling R-HSA-909733 5.972266e-01 0.224 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 6.001707e-01 0.222 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.056401e-01 0.218 0 0
Mismatch Repair R-HSA-5358508 6.056401e-01 0.218 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.056401e-01 0.218 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.056401e-01 0.218 0 0
Apoptotic factor-mediated response R-HSA-111471 6.056401e-01 0.218 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.056401e-01 0.218 0 0
Mitochondrial protein degradation R-HSA-9837999 6.061389e-01 0.217 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.109023e-01 0.214 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.109023e-01 0.214 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.109023e-01 0.214 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.135943e-01 0.212 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.194050e-01 0.208 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.212874e-01 0.207 0 0
Translesion Synthesis by POLH R-HSA-110320 6.212874e-01 0.207 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.212874e-01 0.207 0 0
Specification of the neural plate border R-HSA-9834899 6.212874e-01 0.207 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.212874e-01 0.207 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.212874e-01 0.207 0 0
Other interleukin signaling R-HSA-449836 6.212874e-01 0.207 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.212874e-01 0.207 0 0
Proteasome assembly R-HSA-9907900 6.214127e-01 0.207 0 0
RMTs methylate histone arginines R-HSA-3214858 6.214127e-01 0.207 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.214127e-01 0.207 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.278171e-01 0.202 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.303026e-01 0.200 0 0
Nucleosome assembly R-HSA-774815 6.317026e-01 0.199 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.317026e-01 0.199 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.317026e-01 0.199 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 6.317026e-01 0.199 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.317026e-01 0.199 0 0
Telomere Maintenance R-HSA-157579 6.354290e-01 0.197 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.361004e-01 0.196 0 0
Ca2+ pathway R-HSA-4086398 6.361004e-01 0.196 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.363148e-01 0.196 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.363148e-01 0.196 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.363148e-01 0.196 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.363148e-01 0.196 0 0
Keratan sulfate degradation R-HSA-2022857 6.363148e-01 0.196 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.363148e-01 0.196 0 0
Creatine metabolism R-HSA-71288 6.363148e-01 0.196 0 0
Protein hydroxylation R-HSA-9629569 6.363148e-01 0.196 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.417730e-01 0.193 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.417730e-01 0.193 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.421006e-01 0.192 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 6.442541e-01 0.191 0 0
Signaling by FGFR in disease R-HSA-1226099 6.442541e-01 0.191 0 0
Signaling by ERBB4 R-HSA-1236394 6.442541e-01 0.191 0 0
ROS and RNS production in phagocytes R-HSA-1222556 6.442541e-01 0.191 0 0
FOXO-mediated transcription R-HSA-9614085 6.495343e-01 0.187 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.507467e-01 0.187 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.507467e-01 0.187 0 0
Lagging Strand Synthesis R-HSA-69186 6.507467e-01 0.187 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 6.507467e-01 0.187 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.507467e-01 0.187 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 6.507467e-01 0.187 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.507467e-01 0.187 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.507467e-01 0.187 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 6.516251e-01 0.186 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 6.522780e-01 0.186 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 6.522780e-01 0.186 0 0
UCH proteinases R-HSA-5689603 6.601718e-01 0.180 0 0
Interleukin-1 signaling R-HSA-9020702 6.632727e-01 0.178 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.646069e-01 0.177 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.646069e-01 0.177 0 0
Assembly Of The HIV Virion R-HSA-175474 6.646069e-01 0.177 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.684800e-01 0.175 0 0
DNA Damage Bypass R-HSA-73893 6.706803e-01 0.173 0 0
Potential therapeutics for SARS R-HSA-9679191 6.731834e-01 0.172 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.779177e-01 0.169 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.779177e-01 0.169 0 0
FGFR2 alternative splicing R-HSA-6803529 6.779177e-01 0.169 0 0
Notch-HLH transcription pathway R-HSA-350054 6.779177e-01 0.169 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.779177e-01 0.169 0 0
PI3K Cascade R-HSA-109704 6.798871e-01 0.168 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.798871e-01 0.168 0 0
Azathioprine ADME R-HSA-9748787 6.798871e-01 0.168 0 0
Opioid Signalling R-HSA-111885 6.831846e-01 0.165 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.888826e-01 0.162 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.888826e-01 0.162 0 0
DNA Replication R-HSA-69306 6.893874e-01 0.162 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.904445e-01 0.161 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.904445e-01 0.161 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.907011e-01 0.161 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.907011e-01 0.161 0 0
Termination of O-glycan biosynthesis R-HSA-977068 6.907011e-01 0.161 0 0
Biosynthesis of maresins R-HSA-9018682 6.907011e-01 0.161 0 0
Interleukin-20 family signaling R-HSA-8854691 6.907011e-01 0.161 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 6.907011e-01 0.161 0 0
Carnitine shuttle R-HSA-200425 6.907011e-01 0.161 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 6.907011e-01 0.161 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 6.976693e-01 0.156 0 0
Orc1 removal from chromatin R-HSA-68949 6.976693e-01 0.156 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.976693e-01 0.156 0 0
Amyloid fiber formation R-HSA-977225 6.976880e-01 0.156 0 0
CYP2E1 reactions R-HSA-211999 7.029779e-01 0.153 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.029779e-01 0.153 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.029779e-01 0.153 0 0
Complex III assembly R-HSA-9865881 7.029779e-01 0.153 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.029779e-01 0.153 0 0
Cell surface interactions at the vascular wall R-HSA-202733 7.113140e-01 0.148 0 0
G alpha (q) signalling events R-HSA-416476 7.115477e-01 0.148 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.117880e-01 0.148 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.146255e-01 0.146 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.147681e-01 0.146 0 0
G protein gated Potassium channels R-HSA-1296059 7.147681e-01 0.146 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.147681e-01 0.146 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.147681e-01 0.146 0 0
TGFBR3 expression R-HSA-9839394 7.147681e-01 0.146 0 0
Fertilization R-HSA-1187000 7.147681e-01 0.146 0 0
Formation of the nephric duct R-HSA-9830364 7.147681e-01 0.146 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.147681e-01 0.146 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.147681e-01 0.146 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.147681e-01 0.146 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.147681e-01 0.146 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.186458e-01 0.143 0 0
Gene expression (Transcription) R-HSA-74160 7.189368e-01 0.143 0 0
HDACs deacetylate histones R-HSA-3214815 7.228002e-01 0.141 0 0
G alpha (z) signalling events R-HSA-418597 7.228002e-01 0.141 0 0
Signaling by TGFB family members R-HSA-9006936 7.250979e-01 0.140 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.260909e-01 0.139 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.260909e-01 0.139 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.260909e-01 0.139 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.260909e-01 0.139 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.260909e-01 0.139 0 0
Phospholipid metabolism R-HSA-1483257 7.272935e-01 0.138 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.307765e-01 0.136 0 0
TNF signaling R-HSA-75893 7.307765e-01 0.136 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.312255e-01 0.136 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.369650e-01 0.133 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.369650e-01 0.133 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.369650e-01 0.133 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.369650e-01 0.133 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.369650e-01 0.133 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 7.369650e-01 0.133 0 0
Insulin processing R-HSA-264876 7.369650e-01 0.133 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.384586e-01 0.132 0 0
Dectin-2 family R-HSA-5621480 7.385571e-01 0.132 0 0
Synthesis of PA R-HSA-1483166 7.385571e-01 0.132 0 0
Integration of energy metabolism R-HSA-163685 7.402997e-01 0.131 0 0
Selenoamino acid metabolism R-HSA-2408522 7.441713e-01 0.128 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.461449e-01 0.127 0 0
Generic Transcription Pathway R-HSA-212436 7.461622e-01 0.127 0 0
HIV elongation arrest and recovery R-HSA-167287 7.474080e-01 0.126 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.474080e-01 0.126 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.474080e-01 0.126 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.474080e-01 0.126 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.474080e-01 0.126 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.474080e-01 0.126 0 0
mRNA Capping R-HSA-72086 7.574370e-01 0.121 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.574370e-01 0.121 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.574370e-01 0.121 0 0
Metabolism of polyamines R-HSA-351202 7.607547e-01 0.119 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.670684e-01 0.115 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.670684e-01 0.115 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 7.670684e-01 0.115 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.670684e-01 0.115 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.763179e-01 0.110 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.763179e-01 0.110 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.813015e-01 0.107 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.831924e-01 0.106 0 0
G0 and Early G1 R-HSA-1538133 7.852007e-01 0.105 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.852007e-01 0.105 0 0
DNA strand elongation R-HSA-69190 7.852007e-01 0.105 0 0
Diseases of mitotic cell cycle R-HSA-9675126 7.852007e-01 0.105 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.858915e-01 0.105 0 0
Post-translational protein modification R-HSA-597592 7.931757e-01 0.101 0 0
Keratan sulfate biosynthesis R-HSA-2022854 7.937312e-01 0.100 0 0
Nuclear RNA decay R-HSA-9930044 7.937312e-01 0.100 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.937312e-01 0.100 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.937312e-01 0.100 0 0
Recycling of bile acids and salts R-HSA-159418 7.937312e-01 0.100 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.937312e-01 0.100 0 0
Cardiogenesis R-HSA-9733709 7.937312e-01 0.100 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.937312e-01 0.100 0 0
Cellular response to hypoxia R-HSA-1234174 7.941251e-01 0.100 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.019235e-01 0.096 0 0
RNA Polymerase II Transcription R-HSA-73857 8.062549e-01 0.094 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.062798e-01 0.094 0 0
Potassium Channels R-HSA-1296071 8.068073e-01 0.093 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.068073e-01 0.093 0 0
Keratinization R-HSA-6805567 8.073024e-01 0.093 0 0
Translation R-HSA-72766 8.079635e-01 0.093 0 0
Signaling by NOTCH2 R-HSA-1980145 8.097908e-01 0.092 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.097908e-01 0.092 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.097908e-01 0.092 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.097908e-01 0.092 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 8.097908e-01 0.092 0 0
Transcription of the HIV genome R-HSA-167172 8.121146e-01 0.090 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.165347e-01 0.088 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.173462e-01 0.088 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 8.173462e-01 0.088 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.177921e-01 0.087 0 0
HATs acetylate histones R-HSA-3214847 8.213422e-01 0.085 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.233154e-01 0.084 0 0
RNA Polymerase III Transcription R-HSA-74158 8.246019e-01 0.084 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.246019e-01 0.084 0 0
G1/S-Specific Transcription R-HSA-69205 8.246019e-01 0.084 0 0
Triglyceride catabolism R-HSA-163560 8.246019e-01 0.084 0 0
FLT3 signaling in disease R-HSA-9682385 8.246019e-01 0.084 0 0
RUNX2 regulates bone development R-HSA-8941326 8.246019e-01 0.084 0 0
ECM proteoglycans R-HSA-3000178 8.286881e-01 0.082 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.286881e-01 0.082 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.315698e-01 0.080 0 0
Ubiquinol biosynthesis R-HSA-2142789 8.315698e-01 0.080 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.315698e-01 0.080 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.315698e-01 0.080 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.382613e-01 0.077 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 8.382613e-01 0.077 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.382613e-01 0.077 0 0
Cellular response to starvation R-HSA-9711097 8.387433e-01 0.076 0 0
Interferon gamma signaling R-HSA-877300 8.422219e-01 0.075 0 0
Pentose phosphate pathway R-HSA-71336 8.446873e-01 0.073 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.476288e-01 0.072 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.476288e-01 0.072 0 0
RSV-host interactions R-HSA-9833110 8.476288e-01 0.072 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.487354e-01 0.071 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.508584e-01 0.070 0 0
Diseases of Immune System R-HSA-5260271 8.508584e-01 0.070 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.508584e-01 0.070 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.508584e-01 0.070 0 0
Tryptophan catabolism R-HSA-71240 8.508584e-01 0.070 0 0
Platelet homeostasis R-HSA-418346 8.556127e-01 0.068 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.567847e-01 0.067 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.567847e-01 0.067 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.606213e-01 0.065 0 0
ABC transporter disorders R-HSA-5619084 8.623448e-01 0.064 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.624758e-01 0.064 0 0
HIV Transcription Initiation R-HSA-167161 8.624758e-01 0.064 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.624758e-01 0.064 0 0
Scavenging by Class A Receptors R-HSA-3000480 8.624758e-01 0.064 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.679411e-01 0.062 0 0
Activation of GABAB receptors R-HSA-991365 8.679411e-01 0.062 0 0
GABA B receptor activation R-HSA-977444 8.679411e-01 0.062 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.679411e-01 0.062 0 0
Depyrimidination R-HSA-73928 8.679411e-01 0.062 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.679411e-01 0.062 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 8.683099e-01 0.061 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.731895e-01 0.059 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 8.782297e-01 0.056 0 0
Amine ligand-binding receptors R-HSA-375280 8.782297e-01 0.056 0 0
tRNA processing R-HSA-72306 8.793313e-01 0.056 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.825563e-01 0.054 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.830698e-01 0.054 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 8.830698e-01 0.054 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.830698e-01 0.054 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 8.830698e-01 0.054 0 0
rRNA processing R-HSA-72312 8.831774e-01 0.054 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 8.877178e-01 0.052 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.877178e-01 0.052 0 0
Signaling by TGFBR3 R-HSA-9839373 8.877178e-01 0.052 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 8.921813e-01 0.050 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 8.932885e-01 0.049 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 8.932885e-01 0.049 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.964677e-01 0.047 0 0
NGF-stimulated transcription R-HSA-9031628 8.964677e-01 0.047 0 0
Peptide hormone metabolism R-HSA-2980736 8.991066e-01 0.046 0 0
Pyruvate metabolism R-HSA-70268 8.999935e-01 0.046 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.005839e-01 0.045 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.005839e-01 0.045 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.005839e-01 0.045 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.078750e-01 0.042 0 0
Complex IV assembly R-HSA-9864848 9.083326e-01 0.042 0 0
Neurotransmitter release cycle R-HSA-112310 9.092654e-01 0.041 0 0
mRNA 3'-end processing R-HSA-72187 9.119777e-01 0.040 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.119777e-01 0.040 0 0
Nucleotide biosynthesis R-HSA-8956320 9.154781e-01 0.038 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.188395e-01 0.037 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.203801e-01 0.036 0 0
Paracetamol ADME R-HSA-9753281 9.220675e-01 0.035 0 0
HCMV Late Events R-HSA-9610379 9.231568e-01 0.035 0 0
G alpha (i) signalling events R-HSA-418594 9.282148e-01 0.032 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.302045e-01 0.031 0 0
Triglyceride metabolism R-HSA-8979227 9.337471e-01 0.030 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.337471e-01 0.030 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.346761e-01 0.029 0 0
Regulation of insulin secretion R-HSA-422356 9.346761e-01 0.029 0 0
Metabolism of proteins R-HSA-392499 9.359697e-01 0.029 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.363829e-01 0.029 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.363829e-01 0.029 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.363829e-01 0.029 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.363829e-01 0.029 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.363829e-01 0.029 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.363829e-01 0.029 0 0
tRNA Aminoacylation R-HSA-379724 9.363829e-01 0.029 0 0
GABA receptor activation R-HSA-977443 9.363829e-01 0.029 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.363829e-01 0.029 0 0
ABC-family proteins mediated transport R-HSA-382556 9.388755e-01 0.027 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 9.389141e-01 0.027 0 0
Endogenous sterols R-HSA-211976 9.389141e-01 0.027 0 0
Aquaporin-mediated transport R-HSA-445717 9.389141e-01 0.027 0 0
SLC transporter disorders R-HSA-5619102 9.410477e-01 0.026 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.413446e-01 0.026 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.428180e-01 0.026 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.452642e-01 0.024 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.453550e-01 0.024 0 0
Xenobiotics R-HSA-211981 9.459199e-01 0.024 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.459199e-01 0.024 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.501388e-01 0.022 0 0
Kidney development R-HSA-9830369 9.521233e-01 0.021 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.521233e-01 0.021 0 0
O-linked glycosylation of mucins R-HSA-913709 9.540290e-01 0.020 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.576161e-01 0.019 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.576161e-01 0.019 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.587985e-01 0.018 0 0
Antimicrobial peptides R-HSA-6803157 9.591594e-01 0.018 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.593035e-01 0.018 0 0
Retinoid metabolism and transport R-HSA-975634 9.593035e-01 0.018 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.609237e-01 0.017 0 0
Purine catabolism R-HSA-74259 9.609237e-01 0.017 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.609237e-01 0.017 0 0
Aspirin ADME R-HSA-9749641 9.624796e-01 0.017 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.624796e-01 0.017 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.643531e-01 0.016 0 0
Peptide ligand-binding receptors R-HSA-375276 9.659521e-01 0.015 0 0
Signaling by NOTCH1 R-HSA-1980143 9.667858e-01 0.015 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.693787e-01 0.014 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.705984e-01 0.013 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.708950e-01 0.013 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.728941e-01 0.012 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.728941e-01 0.012 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.729020e-01 0.012 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.739740e-01 0.011 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.760065e-01 0.011 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.783901e-01 0.009 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.787620e-01 0.009 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.787620e-01 0.009 0 0
Nucleotide catabolism R-HSA-8956319 9.801580e-01 0.009 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.804211e-01 0.009 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.819508e-01 0.008 0 0
G alpha (s) signalling events R-HSA-418555 9.828361e-01 0.008 0 0
FCGR activation R-HSA-2029481 9.846614e-01 0.007 0 0
Neddylation R-HSA-8951664 9.879872e-01 0.005 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.884637e-01 0.005 0 0
Metabolism of nucleotides R-HSA-15869 9.923499e-01 0.003 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.929230e-01 0.003 0 0
Bacterial Infection Pathways R-HSA-9824439 9.936224e-01 0.003 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.942398e-01 0.003 0 0
Metabolism of steroids R-HSA-8957322 9.944811e-01 0.002 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.949343e-01 0.002 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.953669e-01 0.002 0 0
Extracellular matrix organization R-HSA-1474244 9.954587e-01 0.002 0 0
Drug ADME R-HSA-9748784 9.963989e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.964029e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.964029e-01 0.002 0 0
Regulation of Complement cascade R-HSA-977606 9.964605e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.967378e-01 0.001 0 0
Respiratory electron transport R-HSA-611105 9.969999e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.975481e-01 0.001 0 0
Diseases of glycosylation R-HSA-3781865 9.975888e-01 0.001 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.975922e-01 0.001 0 0
O-linked glycosylation R-HSA-5173105 9.980806e-01 0.001 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.985577e-01 0.001 0 0
Complement cascade R-HSA-166658 9.986709e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.987751e-01 0.001 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.995368e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.995592e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.997170e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.997734e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.998019e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.998209e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999342e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999938e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999995e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999999e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 1 0
Cell Cycle, Mitotic R-HSA-69278 5.551115e-16 15.256 1 0
Metabolism of RNA R-HSA-8953854 2.697842e-13 12.569 0 0
M Phase R-HSA-68886 3.099954e-11 10.509 1 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.149589e-10 9.939 0 0
Cell Cycle Checkpoints R-HSA-69620 1.563734e-10 9.806 0 0
Cellular responses to stress R-HSA-2262752 2.349524e-09 8.629 0 0
Mitotic Anaphase R-HSA-68882 2.942258e-09 8.531 1 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.500155e-09 8.456 1 0
mRNA Splicing - Major Pathway R-HSA-72163 5.975149e-09 8.224 0 0
Cellular responses to stimuli R-HSA-8953897 7.463753e-09 8.127 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.017156e-08 7.993 0 0
mRNA Splicing R-HSA-72172 1.853867e-08 7.732 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.872581e-08 7.412 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.014151e-08 7.300 0 0
Cellular Senescence R-HSA-2559583 1.298685e-07 6.886 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.295198e-07 6.888 0 0
Signaling by ROBO receptors R-HSA-376176 1.285785e-07 6.891 0 0
G2/M Checkpoints R-HSA-69481 1.512929e-07 6.820 0 0
Axon guidance R-HSA-422475 1.577012e-07 6.802 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.802390e-07 6.744 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.802390e-07 6.744 0 0
Cellular response to heat stress R-HSA-3371556 2.097842e-07 6.678 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.092269e-07 6.510 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.213192e-07 6.493 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.514262e-07 6.454 0 0
Chromatin organization R-HSA-4839726 4.741206e-07 6.324 0 0
Nervous system development R-HSA-9675108 6.496330e-07 6.187 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.900321e-07 6.102 0 0
Ribosome-associated quality control R-HSA-9948299 7.806527e-07 6.108 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.667934e-07 6.115 0 0
Orc1 removal from chromatin R-HSA-68949 8.462956e-07 6.072 0 0
Mitotic Prophase R-HSA-68875 9.677179e-07 6.014 1 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.001347e-06 5.999 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.376597e-06 5.861 0 0
Separation of Sister Chromatids R-HSA-2467813 1.581490e-06 5.801 0 0
Chromatin modifying enzymes R-HSA-3247509 1.665547e-06 5.778 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.314019e-06 5.636 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.779023e-06 5.556 0 0
G1/S Transition R-HSA-69206 2.955360e-06 5.529 0 0
Regulation of CDH1 Function R-HSA-9764561 3.634077e-06 5.440 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.674172e-06 5.435 0 0
Signaling by ALK in cancer R-HSA-9700206 3.674172e-06 5.435 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.882832e-06 5.411 0 0
rRNA processing R-HSA-72312 4.597028e-06 5.338 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.517664e-06 5.258 0 0
UCH proteinases R-HSA-5689603 7.541824e-06 5.123 0 0
Cell junction organization R-HSA-446728 9.142200e-06 5.039 0 0
Apoptosis R-HSA-109581 1.006433e-05 4.997 0 0
S Phase R-HSA-69242 1.037821e-05 4.984 0 0
Stabilization of p53 R-HSA-69541 1.074583e-05 4.969 0 0
Translation initiation complex formation R-HSA-72649 1.329728e-05 4.876 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.338930e-05 4.873 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.416867e-05 4.849 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.416867e-05 4.849 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.449703e-05 4.839 0 0
Cell-Cell communication R-HSA-1500931 1.922583e-05 4.716 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.054921e-05 4.687 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.054921e-05 4.687 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.222404e-05 4.653 0 0
DNA Replication R-HSA-69306 2.179692e-05 4.662 0 0
Host Interactions of HIV factors R-HSA-162909 2.165921e-05 4.664 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.846877e-05 4.546 1 1
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.849982e-05 4.545 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.849982e-05 4.545 0 0
Signaling by NOTCH4 R-HSA-9013694 3.094977e-05 4.509 0 0
Apoptotic execution phase R-HSA-75153 3.655607e-05 4.437 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.043096e-05 4.393 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.896606e-05 4.409 0 0
Metalloprotease DUBs R-HSA-5689901 4.045483e-05 4.393 0 0
Synthesis of DNA R-HSA-69239 4.205286e-05 4.376 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.240171e-05 4.373 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.507467e-05 4.346 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.629773e-05 4.334 0 0
Degradation of DVL R-HSA-4641258 5.706528e-05 4.244 0 0
Regulation of TP53 Activity R-HSA-5633007 5.748883e-05 4.240 0 0
Adherens junctions interactions R-HSA-418990 5.807044e-05 4.236 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.978641e-05 4.223 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.167567e-05 4.145 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.593426e-05 4.120 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.764856e-05 4.110 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 8.209643e-05 4.086 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.549796e-05 4.068 0 0
ISG15 antiviral mechanism R-HSA-1169408 9.196825e-05 4.036 0 0
Oncogene Induced Senescence R-HSA-2559585 9.672273e-05 4.014 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.007250e-04 3.997 0 0
Peptide chain elongation R-HSA-156902 1.045838e-04 3.981 0 0
Deubiquitination R-HSA-5688426 1.109369e-04 3.955 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.143044e-04 3.942 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.118840e-04 3.951 0 0
HSF1-dependent transactivation R-HSA-3371571 1.279549e-04 3.893 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.287234e-04 3.890 0 0
Attenuation phase R-HSA-3371568 1.320190e-04 3.879 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.320190e-04 3.879 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.326756e-04 3.877 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.497146e-04 3.825 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.542945e-04 3.812 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.611885e-04 3.793 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.703701e-04 3.769 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.715682e-04 3.766 0 0
Cellular response to hypoxia R-HSA-1234174 1.695017e-04 3.771 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.715682e-04 3.766 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.763812e-04 3.754 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.823400e-04 3.739 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.957936e-04 3.708 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.957936e-04 3.708 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.081437e-04 3.682 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.018310e-04 3.695 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.175592e-04 3.662 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.175592e-04 3.662 0 0
Eukaryotic Translation Termination R-HSA-72764 2.217712e-04 3.654 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.327155e-04 3.633 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.327155e-04 3.633 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.222826e-04 3.653 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.222826e-04 3.653 0 0
Programmed Cell Death R-HSA-5357801 2.331425e-04 3.632 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.337583e-04 3.631 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.385767e-04 3.622 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.512498e-04 3.600 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.749082e-04 3.561 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.807078e-04 3.552 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.857345e-04 3.544 0 0
Regulation of Apoptosis R-HSA-169911 2.857345e-04 3.544 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.867430e-04 3.543 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.868545e-04 3.542 0 0
PTEN Regulation R-HSA-6807070 2.911645e-04 3.536 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.016710e-04 3.520 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.016710e-04 3.520 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.094127e-04 3.509 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.094127e-04 3.509 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.110067e-04 3.507 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.372449e-04 3.472 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.372449e-04 3.472 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.456321e-04 3.461 0 0
HSF1 activation R-HSA-3371511 3.717122e-04 3.430 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.717122e-04 3.430 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.425090e-04 3.354 0 0
Striated Muscle Contraction R-HSA-390522 4.810671e-04 3.318 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.689250e-04 3.329 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.791849e-04 3.319 0 0
RMTs methylate histone arginines R-HSA-3214858 4.524899e-04 3.344 0 0
Vpu mediated degradation of CD4 R-HSA-180534 4.810671e-04 3.318 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.833139e-04 3.316 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.029522e-04 3.298 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.267452e-04 3.278 0 0
Degradation of CDH1 R-HSA-9766229 5.358777e-04 3.271 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 5.663174e-04 3.247 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.663174e-04 3.247 0 0
Cell-cell junction organization R-HSA-421270 5.707661e-04 3.244 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.925511e-04 3.227 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.925511e-04 3.227 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.925511e-04 3.227 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.040673e-04 3.152 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.553674e-04 3.122 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.694314e-04 3.114 0 0
G alpha (12/13) signalling events R-HSA-416482 7.976286e-04 3.098 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.996379e-04 3.097 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.996379e-04 3.097 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.096374e-04 3.092 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.109079e-04 3.091 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.109079e-04 3.091 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.753443e-04 3.058 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.753443e-04 3.058 0 0
Regulation of PTEN localization R-HSA-8948747 9.027597e-04 3.044 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 9.125736e-04 3.040 0 0
Mitotic G2-G2/M phases R-HSA-453274 9.144776e-04 3.039 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.744691e-04 3.011 1 1
Interactions of Vpr with host cellular proteins R-HSA-176033 9.760004e-04 3.011 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.823474e-04 3.008 0 0
mRNA 3'-end processing R-HSA-72187 9.890019e-04 3.005 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.030221e-03 2.987 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.030221e-03 2.987 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.043837e-03 2.981 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.050645e-03 2.979 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.059819e-03 2.975 0 0
Influenza Infection R-HSA-168255 1.061677e-03 2.974 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.180836e-03 2.928 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.199638e-03 2.921 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.201552e-03 2.920 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.217993e-03 2.914 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.332748e-03 2.875 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.282380e-03 2.892 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.361976e-03 2.866 0 0
G2/M Transition R-HSA-69275 1.261841e-03 2.899 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.319190e-03 2.880 0 0
Degradation of AXIN R-HSA-4641257 1.282380e-03 2.892 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.407196e-03 2.852 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.407196e-03 2.852 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.407196e-03 2.852 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.427250e-03 2.845 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.436507e-03 2.843 0 0
Mitotic Prometaphase R-HSA-68877 1.485623e-03 2.828 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.488246e-03 2.827 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.508985e-03 2.821 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.581064e-03 2.801 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.640219e-03 2.785 0 0
Ub-specific processing proteases R-HSA-5689880 1.663779e-03 2.779 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.685970e-03 2.773 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.759026e-03 2.755 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.871307e-03 2.728 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.875951e-03 2.727 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.206145e-03 2.656 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.990608e-03 2.701 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.098272e-03 2.678 0 0
TCR signaling R-HSA-202403 2.117550e-03 2.674 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.206145e-03 2.656 0 0
Signaling by Hippo R-HSA-2028269 2.122622e-03 2.673 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.098272e-03 2.678 0 0
NRAGE signals death through JNK R-HSA-193648 2.075615e-03 2.683 0 0
Selenocysteine synthesis R-HSA-2408557 2.114896e-03 2.675 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.217997e-03 2.654 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.221545e-03 2.653 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.221545e-03 2.653 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.252851e-03 2.647 1 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.289815e-03 2.640 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.307383e-03 2.637 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.308319e-03 2.637 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.452187e-03 2.610 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.452187e-03 2.610 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.650861e-03 2.577 0 0
Viral mRNA Translation R-HSA-192823 2.721724e-03 2.565 0 0
Proteasome assembly R-HSA-9907900 2.755133e-03 2.560 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.789475e-03 2.554 0 0
Co-inhibition by PD-1 R-HSA-389948 2.800974e-03 2.553 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.310929e-03 2.480 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.310929e-03 2.480 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.310929e-03 2.480 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.310929e-03 2.480 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.310929e-03 2.480 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.310929e-03 2.480 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.310929e-03 2.480 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.310929e-03 2.480 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.310929e-03 2.480 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.310929e-03 2.480 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.310929e-03 2.480 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.251284e-03 2.488 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.903700e-03 2.537 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.006714e-03 2.522 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.243235e-03 2.489 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.995941e-03 2.523 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.198471e-03 2.495 0 0
Semaphorin interactions R-HSA-373755 3.075764e-03 2.512 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.953989e-03 2.530 0 0
HIV Infection R-HSA-162906 2.988879e-03 2.524 0 0
PCP/CE pathway R-HSA-4086400 3.382907e-03 2.471 0 0
snRNP Assembly R-HSA-191859 3.439747e-03 2.463 0 0
Metabolism of non-coding RNA R-HSA-194441 3.439747e-03 2.463 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.439747e-03 2.463 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.476587e-03 2.459 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.684654e-03 2.434 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.826900e-03 2.417 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.870651e-03 2.412 0 0
Josephin domain DUBs R-HSA-5689877 3.870651e-03 2.412 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.870651e-03 2.412 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.989059e-03 2.399 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.989059e-03 2.399 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.989059e-03 2.399 0 0
Signaling by RAS mutants R-HSA-6802949 3.989059e-03 2.399 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.183335e-03 2.378 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.280123e-03 2.369 0 0
Gene expression (Transcription) R-HSA-74160 4.377364e-03 2.359 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.645247e-03 2.333 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.645247e-03 2.333 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.645247e-03 2.333 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.873125e-03 2.312 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.873125e-03 2.312 0 0
Hedgehog 'on' state R-HSA-5632684 4.972032e-03 2.303 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.034221e-03 2.298 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.145565e-03 2.289 0 0
Cyclin D associated events in G1 R-HSA-69231 6.288682e-03 2.201 0 0
G1 Phase R-HSA-69236 6.288682e-03 2.201 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.825368e-03 2.235 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.671011e-03 2.246 0 0
G1/S-Specific Transcription R-HSA-69205 6.402917e-03 2.194 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.446295e-03 2.191 0 0
RNA Polymerase I Transcription R-HSA-73864 6.589179e-03 2.181 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.953991e-03 2.158 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.994292e-03 2.155 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.482414e-03 2.126 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 7.619133e-03 2.118 0 0
Intracellular signaling by second messengers R-HSA-9006925 7.627444e-03 2.118 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.668993e-03 2.115 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.787890e-03 2.109 0 0
Signaling by NOTCH R-HSA-157118 7.985225e-03 2.098 0 0
HDACs deacetylate histones R-HSA-3214815 8.099240e-03 2.092 0 0
Signaling by NOTCH3 R-HSA-9012852 8.099240e-03 2.092 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 8.190759e-03 2.087 0 0
Signaling by ERBB2 R-HSA-1227986 8.297611e-03 2.081 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.322257e-03 2.080 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.498616e-03 2.071 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.498616e-03 2.071 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 9.264649e-03 2.033 0 0
Activation of the pre-replicative complex R-HSA-68962 9.311422e-03 2.031 0 0
Processing of DNA double-strand break ends R-HSA-5693607 9.608003e-03 2.017 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.670172e-03 2.015 0 0
Nuclear import of Rev protein R-HSA-180746 1.027510e-02 1.988 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.032322e-02 1.986 0 0
Translation R-HSA-72766 1.075684e-02 1.968 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.081302e-02 1.966 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.095859e-02 1.960 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.100937e-02 1.958 0 0
DNA Double Strand Break Response R-HSA-5693606 1.102214e-02 1.958 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 1.103046e-02 1.957 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.135058e-02 1.945 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.135058e-02 1.945 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.137063e-02 1.944 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.217513e-02 1.915 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.242729e-02 1.906 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.231138e-02 1.910 0 0
G0 and Early G1 R-HSA-1538133 1.368993e-02 1.864 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.366059e-02 1.865 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.368993e-02 1.864 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.253973e-02 1.902 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.160312e-02 1.935 0 0
Death Receptor Signaling R-HSA-73887 1.325961e-02 1.877 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 1.368993e-02 1.864 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.380217e-02 1.860 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.443999e-02 1.840 0 0
L1CAM interactions R-HSA-373760 1.519761e-02 1.818 0 0
Protein ubiquitination R-HSA-8852135 1.585437e-02 1.800 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.629266e-02 1.788 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.639529e-02 1.785 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.639529e-02 1.785 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.646381e-02 1.783 0 0
Deadenylation of mRNA R-HSA-429947 1.663506e-02 1.779 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.663506e-02 1.779 0 0
Neurodegenerative Diseases R-HSA-8863678 1.663506e-02 1.779 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.730404e-02 1.762 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.730404e-02 1.762 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.808087e-02 1.743 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.808087e-02 1.743 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.808087e-02 1.743 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.832548e-02 1.737 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.897091e-02 1.722 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.009231e-02 1.697 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.009231e-02 1.697 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.019614e-02 1.695 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.029200e-02 1.693 0 0
Nucleotide Excision Repair R-HSA-5696398 2.037010e-02 1.691 0 0
DNA Repair R-HSA-73894 2.051054e-02 1.688 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.083883e-02 1.681 0 0
tRNA processing in the nucleus R-HSA-6784531 2.097129e-02 1.678 0 0
Recycling pathway of L1 R-HSA-437239 2.112428e-02 1.675 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.115505e-02 1.675 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.188867e-02 1.660 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.193268e-02 1.659 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.193268e-02 1.659 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.234688e-02 1.651 0 0
Diseases of Cellular Senescence R-HSA-9630747 2.289132e-02 1.640 0 0
Diseases of cellular response to stress R-HSA-9675132 2.289132e-02 1.640 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.289132e-02 1.640 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.298956e-02 1.638 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.369541e-02 1.625 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.404405e-02 1.619 0 0
Smooth Muscle Contraction R-HSA-445355 2.418603e-02 1.616 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.450321e-02 1.611 0 0
ER-Phagosome pathway R-HSA-1236974 2.577330e-02 1.589 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.598451e-02 1.585 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.598451e-02 1.585 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.599794e-02 1.585 0 0
Translesion synthesis by REV1 R-HSA-110312 2.599794e-02 1.585 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.615468e-02 1.582 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.615468e-02 1.582 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.615468e-02 1.582 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.690416e-02 1.570 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.288899e-02 1.483 0 0
Translesion synthesis by POLI R-HSA-5656121 3.288899e-02 1.483 0 0
mTORC1-mediated signalling R-HSA-166208 2.728874e-02 1.564 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.169617e-02 1.499 0 0
Nucleosome assembly R-HSA-774815 3.169617e-02 1.499 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.673920e-02 1.573 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.830953e-02 1.548 0 0
Translesion Synthesis by POLH R-HSA-110320 3.015063e-02 1.521 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 3.240336e-02 1.489 0 0
Cellular response to starvation R-HSA-9711097 2.756581e-02 1.560 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.288899e-02 1.483 0 0
Signaling by TGFB family members R-HSA-9006936 3.173216e-02 1.499 0 0
Homology Directed Repair R-HSA-5693538 2.915429e-02 1.535 0 0
ESR-mediated signaling R-HSA-8939211 2.867681e-02 1.542 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.770055e-02 1.558 0 0
Somitogenesis R-HSA-9824272 3.169617e-02 1.499 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.049160e-02 1.516 0 0
Regulation of BACH1 activity R-HSA-9708530 3.288899e-02 1.483 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.983278e-02 1.525 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.946509e-02 1.531 0 0
RNA Polymerase II Transcription R-HSA-73857 3.289545e-02 1.483 0 0
Maturation of protein E R-HSA-9683683 3.336733e-02 1.477 0 0
Maturation of protein E R-HSA-9694493 3.336733e-02 1.477 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.419673e-02 1.466 0 0
MAPK family signaling cascades R-HSA-5683057 3.470750e-02 1.460 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.497083e-02 1.456 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.497083e-02 1.456 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.509209e-02 1.455 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.578886e-02 1.446 0 0
G-protein beta:gamma signalling R-HSA-397795 3.578886e-02 1.446 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.578886e-02 1.446 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.589414e-02 1.445 0 0
MAP2K and MAPK activation R-HSA-5674135 3.633942e-02 1.440 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.669370e-02 1.435 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.669370e-02 1.435 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.669370e-02 1.435 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.669370e-02 1.435 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.669370e-02 1.435 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.669370e-02 1.435 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.686469e-02 1.433 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.013190e-02 1.397 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.013190e-02 1.397 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.013190e-02 1.397 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.015717e-02 1.396 0 0
Late endosomal microautophagy R-HSA-9615710 4.084963e-02 1.389 0 0
Translesion synthesis by POLK R-HSA-5655862 4.090094e-02 1.388 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.090094e-02 1.388 0 0
Platelet degranulation R-HSA-114608 4.117109e-02 1.385 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.155654e-02 1.381 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.173690e-02 1.379 0 0
Signaling by WNT R-HSA-195721 4.360523e-02 1.360 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.388077e-02 1.358 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.395148e-02 1.357 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.473137e-02 1.349 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.473137e-02 1.349 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.473137e-02 1.349 0 0
Meiotic synapsis R-HSA-1221632 4.509421e-02 1.346 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.536197e-02 1.343 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.617647e-02 1.336 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.653146e-02 1.332 0 0
HATs acetylate histones R-HSA-3214847 4.659064e-02 1.332 0 0
Downstream TCR signaling R-HSA-202424 4.679135e-02 1.330 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.724138e-02 1.326 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.760130e-02 1.322 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.760130e-02 1.322 0 0
Pexophagy R-HSA-9664873 4.760130e-02 1.322 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.764849e-02 1.322 0 0
Interleukin-37 signaling R-HSA-9008059 4.764849e-02 1.322 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.886532e-02 1.311 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.962147e-02 1.304 0 0
DNA Damage Bypass R-HSA-73893 5.189213e-02 1.285 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.314374e-02 1.275 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.467455e-02 1.262 0 0
Myogenesis R-HSA-525793 5.467455e-02 1.262 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.467455e-02 1.262 0 0
PERK regulates gene expression R-HSA-381042 5.494915e-02 1.260 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.516829e-02 1.258 0 0
HIV Life Cycle R-HSA-162587 5.545050e-02 1.256 0 0
Signal Transduction R-HSA-162582 5.572450e-02 1.254 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.587273e-02 1.253 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.587273e-02 1.253 0 0
Manipulation of host energy metabolism R-HSA-9636667 7.497320e-02 1.125 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 7.497320e-02 1.125 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 7.497320e-02 1.125 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 7.497320e-02 1.125 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 7.497320e-02 1.125 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 7.497320e-02 1.125 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 7.497320e-02 1.125 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 7.497320e-02 1.125 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 7.497320e-02 1.125 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 6.230578e-02 1.205 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 6.230578e-02 1.205 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 6.230578e-02 1.205 0 0
MECP2 regulates transcription factors R-HSA-9022707 6.492719e-02 1.188 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.492719e-02 1.188 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.492719e-02 1.188 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 6.492719e-02 1.188 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.854164e-02 1.164 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.854164e-02 1.164 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.047376e-02 1.218 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.277411e-02 1.202 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.359087e-02 1.197 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.359087e-02 1.197 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.261429e-02 1.203 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.136044e-02 1.212 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.190217e-02 1.143 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.371508e-02 1.196 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.244707e-02 1.140 0 0
Signaling by EGFR R-HSA-177929 6.243579e-02 1.205 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 7.094571e-02 1.149 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.624865e-02 1.179 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.697929e-02 1.174 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.342520e-02 1.134 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.497320e-02 1.125 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.854164e-02 1.164 0 0
Signaling by TGFBR3 R-HSA-9839373 6.697929e-02 1.174 0 0
Diseases of programmed cell death R-HSA-9645723 6.317216e-02 1.199 0 0
Circadian clock R-HSA-9909396 6.268398e-02 1.203 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.337796e-02 1.134 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.743272e-02 1.241 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.854164e-02 1.164 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 6.089916e-02 1.215 0 0
Signaling by Interleukins R-HSA-449147 6.286059e-02 1.202 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 5.981418e-02 1.223 0 0
Integration of provirus R-HSA-162592 7.703925e-02 1.113 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 7.703925e-02 1.113 0 0
NF-kB is activated and signals survival R-HSA-209560 7.703925e-02 1.113 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.703925e-02 1.113 0 0
Hedgehog 'off' state R-HSA-5610787 7.795181e-02 1.108 0 0
ABC-family proteins mediated transport R-HSA-382556 7.795181e-02 1.108 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.935011e-02 1.100 0 0
Phosphorylation of the APC/C R-HSA-176412 8.273847e-02 1.082 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 8.273847e-02 1.082 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.273847e-02 1.082 0 0
Negative regulation of FLT3 R-HSA-9706369 8.273847e-02 1.082 0 0
NGF-stimulated transcription R-HSA-9031628 8.294598e-02 1.081 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 8.294598e-02 1.081 0 0
Chromosome Maintenance R-HSA-73886 8.331248e-02 1.079 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.379858e-02 1.077 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.404450e-02 1.075 0 0
Type I hemidesmosome assembly R-HSA-446107 8.496014e-02 1.071 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 8.496014e-02 1.071 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 8.496014e-02 1.071 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 8.496014e-02 1.071 0 0
Modulation by Mtb of host immune system R-HSA-9637628 8.496014e-02 1.071 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.510403e-02 1.070 0 0
Interleukin-12 signaling R-HSA-9020591 8.624004e-02 1.064 0 0
Inositol phosphate metabolism R-HSA-1483249 8.660681e-02 1.062 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 8.897716e-02 1.051 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 8.897716e-02 1.051 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 8.897716e-02 1.051 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 8.897716e-02 1.051 0 0
Interleukin-12 family signaling R-HSA-447115 9.104776e-02 1.041 0 0
Dual Incision in GG-NER R-HSA-5696400 9.278457e-02 1.033 0 0
Signaling by NOTCH2 R-HSA-1980145 9.278457e-02 1.033 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.278457e-02 1.033 0 0
EPH-Ephrin signaling R-HSA-2682334 9.301805e-02 1.031 0 0
Muscle contraction R-HSA-397014 9.353581e-02 1.029 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 9.471890e-02 1.024 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 9.471890e-02 1.024 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 9.471890e-02 1.024 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 9.471890e-02 1.024 0 0
Activation of BH3-only proteins R-HSA-114452 9.559156e-02 1.020 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.594939e-02 1.018 0 0
Disorders of Developmental Biology R-HSA-9675151 9.843956e-02 1.007 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.843956e-02 1.007 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 9.843956e-02 1.007 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.843956e-02 1.007 0 0
Basigin interactions R-HSA-210991 9.900452e-02 1.004 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.900452e-02 1.004 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.900452e-02 1.004 0 0
Aggrephagy R-HSA-9646399 1.000171e-01 1.000 0 0
ABC transporter disorders R-HSA-5619084 1.011525e-01 0.995 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.029187e-01 0.988 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.037649e-01 0.984 0 0
TNF signaling R-HSA-75893 1.055802e-01 0.976 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.055802e-01 0.976 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.388442e-01 0.857 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.388442e-01 0.857 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.388442e-01 0.857 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.388442e-01 0.857 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.388442e-01 0.857 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.388442e-01 0.857 0 0
Regulation of TP53 Expression R-HSA-6804754 1.211943e-01 0.917 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.195606e-01 0.922 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 1.195606e-01 0.922 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.195606e-01 0.922 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 1.195606e-01 0.922 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.195606e-01 0.922 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.195606e-01 0.922 0 0
ALK mutants bind TKIs R-HSA-9700645 1.076268e-01 0.968 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 1.533952e-01 0.814 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.533952e-01 0.814 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.533952e-01 0.814 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.326968e-01 0.877 0 0
2-LTR circle formation R-HSA-164843 1.326968e-01 0.877 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.326968e-01 0.877 0 0
Formation of axial mesoderm R-HSA-9796292 1.142720e-01 0.942 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.355812e-01 0.868 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.585026e-01 0.800 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 1.341495e-01 0.872 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.142660e-01 0.942 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.142660e-01 0.942 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.540074e-01 0.812 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.540074e-01 0.812 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.262205e-01 0.899 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.262205e-01 0.899 0 0
Packaging Of Telomere Ends R-HSA-171306 1.262205e-01 0.899 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 1.418739e-01 0.848 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.161894e-01 0.935 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.584386e-01 0.800 0 0
DNA methylation R-HSA-5334118 1.584386e-01 0.800 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.584386e-01 0.800 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.211824e-01 0.917 0 0
RNA Polymerase III Transcription R-HSA-74158 1.161894e-01 0.935 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.110710e-01 0.954 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.354138e-01 0.868 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.270663e-01 0.896 0 0
EGFR downregulation R-HSA-182971 1.080126e-01 0.967 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.155987e-01 0.937 0 0
DNA strand elongation R-HSA-69190 1.212937e-01 0.916 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.066798e-01 0.972 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.306821e-01 0.884 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.526791e-01 0.816 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.076268e-01 0.968 0 0
Regulation of CDH11 function R-HSA-9762292 1.326968e-01 0.877 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.355812e-01 0.868 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.485884e-01 0.828 0 0
Mismatch Repair R-HSA-5358508 1.341495e-01 0.872 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.473495e-01 0.832 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.473495e-01 0.832 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.473495e-01 0.832 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.473495e-01 0.832 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.482006e-01 0.829 0 0
Neurofascin interactions R-HSA-447043 1.533952e-01 0.814 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.533952e-01 0.814 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.168021e-01 0.933 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.263713e-01 0.898 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.520184e-01 0.818 0 0
Signaling by NOTCH1 R-HSA-1980143 1.336792e-01 0.874 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.142660e-01 0.942 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.104165e-01 0.957 0 0
The NLRP3 inflammasome R-HSA-844456 1.540074e-01 0.812 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.140639e-01 0.943 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.195606e-01 0.922 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.142720e-01 0.942 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.585026e-01 0.800 0 0
Cardiogenesis R-HSA-9733709 1.354138e-01 0.868 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.540074e-01 0.812 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.339981e-01 0.873 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.354138e-01 0.868 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.585026e-01 0.800 0 0
Cellular response to chemical stress R-HSA-9711123 1.272038e-01 0.896 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.473495e-01 0.832 0 0
Developmental Biology R-HSA-1266738 1.406318e-01 0.852 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 1.211943e-01 0.917 0 0
Unwinding of DNA R-HSA-176974 1.076268e-01 0.968 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.585026e-01 0.800 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.341495e-01 0.872 0 0
Presynaptic function of Kainate receptors R-HSA-500657 1.341495e-01 0.872 0 0
MTOR signalling R-HSA-165159 1.351856e-01 0.869 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.405714e-01 0.852 0 0
Signaling by Hedgehog R-HSA-5358351 1.340696e-01 0.873 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.093530e-01 0.961 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.585026e-01 0.800 0 0
Syndecan interactions R-HSA-3000170 1.482006e-01 0.829 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.168021e-01 0.933 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.585026e-01 0.800 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.497101e-01 0.825 0 0
Interleukin-1 signaling R-HSA-9020702 1.237085e-01 0.908 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.533952e-01 0.814 0 0
p75NTR signals via NF-kB R-HSA-193639 1.585026e-01 0.800 0 0
Interleukin-1 family signaling R-HSA-446652 1.146629e-01 0.941 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.142660e-01 0.942 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.195606e-01 0.922 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.584101e-01 0.800 0 0
FLT3 Signaling R-HSA-9607240 1.110710e-01 0.954 0 0
Selenoamino acid metabolism R-HSA-2408522 1.146887e-01 0.940 0 0
PECAM1 interactions R-HSA-210990 1.598964e-01 0.796 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.598964e-01 0.796 0 0
Generic Transcription Pathway R-HSA-212436 1.617474e-01 0.791 0 0
Meiosis R-HSA-1500620 1.652049e-01 0.782 0 0
RAF activation R-HSA-5673000 1.660527e-01 0.780 0 0
Mitophagy R-HSA-5205647 1.660527e-01 0.780 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.660527e-01 0.780 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.663365e-01 0.779 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 1.667576e-01 0.778 0 0
Signaling by NTRKs R-HSA-166520 1.709132e-01 0.767 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.711444e-01 0.767 0 0
Generation of second messenger molecules R-HSA-202433 1.717876e-01 0.765 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.717876e-01 0.765 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.717876e-01 0.765 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.717967e-01 0.765 0 0
MET interacts with TNS proteins R-HSA-8875513 1.724155e-01 0.763 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.724155e-01 0.763 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.724155e-01 0.763 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.724155e-01 0.763 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 1.750727e-01 0.757 0 0
Negative regulation of MET activity R-HSA-6807004 1.750727e-01 0.757 0 0
Nephrin family interactions R-HSA-373753 1.750727e-01 0.757 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.758647e-01 0.755 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.758647e-01 0.755 0 0
Interferon Signaling R-HSA-913531 1.761184e-01 0.754 0 0
DAG and IP3 signaling R-HSA-1489509 1.761328e-01 0.754 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.761328e-01 0.754 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.761328e-01 0.754 0 0
Prolonged ERK activation events R-HSA-169893 1.828712e-01 0.738 0 0
Signaling by PTK6 R-HSA-8848021 1.837251e-01 0.736 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.837251e-01 0.736 0 0
Long-term potentiation R-HSA-9620244 1.862795e-01 0.730 0 0
TGFBR3 expression R-HSA-9839394 1.862795e-01 0.730 0 0
PI Metabolism R-HSA-1483255 1.862908e-01 0.730 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.873742e-01 0.727 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 1.889235e-01 0.724 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.897978e-01 0.722 0 0
CHL1 interactions R-HSA-447041 1.897978e-01 0.722 0 0
Neurexins and neuroligins R-HSA-6794361 1.935821e-01 0.713 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.940955e-01 0.712 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.949536e-01 0.710 0 0
Dual incision in TC-NER R-HSA-6782135 1.954534e-01 0.709 0 0
Telomere Maintenance R-HSA-157579 1.972126e-01 0.705 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.972332e-01 0.705 0 0
CaM pathway R-HSA-111997 1.996327e-01 0.700 0 0
Calmodulin induced events R-HSA-111933 1.996327e-01 0.700 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.035676e-01 0.691 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.085069e-01 0.681 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.085069e-01 0.681 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.085069e-01 0.681 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.085069e-01 0.681 0 0
Selective autophagy R-HSA-9663891 2.096189e-01 0.679 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.104625e-01 0.677 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.130678e-01 0.671 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.584177e-01 0.588 0 0
MGMT-mediated DNA damage reversal R-HSA-5657655 2.584177e-01 0.588 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.584177e-01 0.588 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.584177e-01 0.588 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.584177e-01 0.588 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.584177e-01 0.588 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.584177e-01 0.588 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.584177e-01 0.588 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.584177e-01 0.588 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.584177e-01 0.588 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.584177e-01 0.588 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.584177e-01 0.588 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.263587e-01 0.645 0 0
HCN channels R-HSA-1296061 2.263587e-01 0.645 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.263587e-01 0.645 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.263587e-01 0.645 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.263587e-01 0.645 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.263587e-01 0.645 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 3.613940e-01 0.442 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.613940e-01 0.442 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.613940e-01 0.442 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.613940e-01 0.442 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.613940e-01 0.442 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.613940e-01 0.442 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 3.613940e-01 0.442 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.613940e-01 0.442 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.613940e-01 0.442 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.613940e-01 0.442 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.613940e-01 0.442 0 0
IRS activation R-HSA-74713 2.812815e-01 0.551 0 0
G2 Phase R-HSA-68911 2.812815e-01 0.551 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.812815e-01 0.551 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 2.812815e-01 0.551 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 2.812815e-01 0.551 0 0
Formation of annular gap junctions R-HSA-196025 2.281000e-01 0.642 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.676727e-01 0.572 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.676727e-01 0.572 0 0
ARMS-mediated activation R-HSA-170984 2.676727e-01 0.572 0 0
Gap junction degradation R-HSA-190873 2.676727e-01 0.572 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 2.676727e-01 0.572 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.676727e-01 0.572 0 0
Calcineurin activates NFAT R-HSA-2025928 2.676727e-01 0.572 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.358725e-01 0.474 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.358725e-01 0.474 0 0
Cam-PDE 1 activation R-HSA-111957 3.358725e-01 0.474 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.358725e-01 0.474 0 0
Phosphorylation of Emi1 R-HSA-176417 3.358725e-01 0.474 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.358725e-01 0.474 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 2.511878e-01 0.600 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.079416e-01 0.512 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.079416e-01 0.512 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.352197e-01 0.629 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.352197e-01 0.629 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.203670e-01 0.657 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.891654e-01 0.410 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.891654e-01 0.410 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 3.891654e-01 0.410 0 0
Polo-like kinase mediated events R-HSA-156711 2.628147e-01 0.580 0 0
Ephrin signaling R-HSA-3928664 2.628147e-01 0.580 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.628147e-01 0.580 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.278831e-01 0.642 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.169593e-01 0.499 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.169593e-01 0.499 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.169593e-01 0.499 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.910962e-01 0.536 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.690350e-01 0.570 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.327138e-01 0.633 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.203273e-01 0.657 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.722827e-01 0.565 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.943006e-01 0.531 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.198717e-01 0.495 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.198717e-01 0.495 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.198717e-01 0.495 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.198717e-01 0.495 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.504153e-01 0.455 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.885900e-01 0.411 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.885900e-01 0.411 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.737348e-01 0.563 0 0
G protein gated Potassium channels R-HSA-1296059 3.200074e-01 0.495 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 3.200074e-01 0.495 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 3.200074e-01 0.495 0 0
Lagging Strand Synthesis R-HSA-69186 3.489551e-01 0.457 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.489551e-01 0.457 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.489551e-01 0.457 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.186907e-01 0.497 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.460225e-01 0.461 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.281471e-01 0.368 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.281471e-01 0.368 0 0
Pervasive developmental disorders R-HSA-9005895 4.281471e-01 0.368 0 0
Disorders of Nervous System Development R-HSA-9697154 4.281471e-01 0.368 0 0
Polymerase switching R-HSA-69091 4.281471e-01 0.368 0 0
Leading Strand Synthesis R-HSA-69109 4.281471e-01 0.368 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.281471e-01 0.368 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.281471e-01 0.368 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.281471e-01 0.368 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.281471e-01 0.368 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.281471e-01 0.368 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.921110e-01 0.534 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.109954e-01 0.507 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.722171e-01 0.429 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.171538e-01 0.380 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.171538e-01 0.380 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.827083e-01 0.549 0 0
Notch-HLH transcription pathway R-HSA-350054 4.073467e-01 0.390 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.073467e-01 0.390 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.177769e-01 0.498 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.903215e-01 0.409 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.296216e-01 0.482 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.246565e-01 0.372 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.143518e-01 0.383 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.050668e-01 0.392 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.050668e-01 0.392 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.745082e-01 0.427 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.745082e-01 0.427 0 0
Centrosome maturation R-HSA-380287 3.618339e-01 0.441 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.503338e-01 0.456 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.654104e-01 0.437 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.273537e-01 0.369 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.805911e-01 0.420 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.332516e-01 0.477 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.938037e-01 0.532 0 0
Extension of Telomeres R-HSA-180786 4.188208e-01 0.378 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.111688e-01 0.386 0 0
Adipogenesis R-HSA-9843745 3.599948e-01 0.444 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.722171e-01 0.429 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 4.171538e-01 0.380 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.073467e-01 0.390 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.169593e-01 0.499 0 0
DARPP-32 events R-HSA-180024 4.246565e-01 0.372 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.443454e-01 0.612 0 0
Nuclear RNA decay R-HSA-9930044 2.327138e-01 0.633 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.174095e-01 0.663 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.504153e-01 0.455 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.171538e-01 0.380 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.460225e-01 0.461 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.737348e-01 0.563 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.263587e-01 0.645 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.613940e-01 0.442 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.511878e-01 0.600 0 0
CREB phosphorylation R-HSA-199920 3.891654e-01 0.410 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.169593e-01 0.499 0 0
Trafficking of AMPA receptors R-HSA-399719 3.186907e-01 0.497 0 0
Budding and maturation of HIV virion R-HSA-162588 3.186907e-01 0.497 0 0
Ca2+ pathway R-HSA-4086398 3.296216e-01 0.482 0 0
Signal amplification R-HSA-392518 2.737348e-01 0.563 0 0
FOXO-mediated transcription R-HSA-9614085 2.948435e-01 0.530 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.912857e-01 0.536 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.912857e-01 0.536 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.194610e-01 0.659 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.497015e-01 0.603 0 0
Ca-dependent events R-HSA-111996 3.343206e-01 0.476 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.546674e-01 0.594 0 0
Membrane Trafficking R-HSA-199991 3.184551e-01 0.497 0 0
Activation and oligomerization of BAK protein R-HSA-111452 2.584177e-01 0.588 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.812815e-01 0.551 0 0
TGFBR3 PTM regulation R-HSA-9839383 2.281000e-01 0.642 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.194610e-01 0.659 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.358725e-01 0.474 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.352197e-01 0.629 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.352197e-01 0.629 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.327138e-01 0.633 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.171538e-01 0.380 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.171538e-01 0.380 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.898331e-01 0.409 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.903215e-01 0.409 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.628147e-01 0.580 0 0
Signal transduction by L1 R-HSA-445144 3.198717e-01 0.495 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.812815e-01 0.551 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.305320e-01 0.481 0 0
Signaling by VEGF R-HSA-194138 2.777578e-01 0.556 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.837884e-01 0.547 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 3.483955e-01 0.458 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.705656e-01 0.568 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.938037e-01 0.532 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.891654e-01 0.410 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.628147e-01 0.580 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.838931e-01 0.416 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.139213e-01 0.503 0 0
TBC/RABGAPs R-HSA-8854214 3.549378e-01 0.450 0 0
Protein methylation R-HSA-8876725 3.169593e-01 0.499 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.548230e-01 0.594 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.781689e-01 0.422 0 0
Glycogen metabolism R-HSA-8982491 4.050668e-01 0.392 0 0
Glycogen synthesis R-HSA-3322077 3.198717e-01 0.495 0 0
HDMs demethylate histones R-HSA-3214842 3.200074e-01 0.495 0 0
Gastrulation R-HSA-9758941 2.964014e-01 0.528 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.164535e-01 0.500 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.584177e-01 0.588 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.584177e-01 0.588 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.263587e-01 0.645 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.613940e-01 0.442 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.676727e-01 0.572 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.676727e-01 0.572 0 0
Proton/oligopeptide cotransporters R-HSA-427975 3.358725e-01 0.474 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.497818e-01 0.602 0 0
Protein hydroxylation R-HSA-9629569 3.198717e-01 0.495 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.737348e-01 0.563 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.460225e-01 0.461 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.281471e-01 0.368 0 0
Meiotic recombination R-HSA-912446 2.725304e-01 0.565 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.392421e-01 0.469 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.938037e-01 0.532 0 0
Heme signaling R-HSA-9707616 3.568067e-01 0.448 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.676727e-01 0.572 0 0
Regulation of signaling by CBL R-HSA-912631 2.910962e-01 0.536 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.186907e-01 0.497 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.676727e-01 0.572 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.676727e-01 0.572 0 0
Glycogen storage diseases R-HSA-3229121 2.352197e-01 0.629 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.443454e-01 0.612 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.605341e-01 0.443 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.546674e-01 0.594 0 0
Inflammasomes R-HSA-622312 3.984675e-01 0.400 0 0
Glycolysis R-HSA-70171 3.079923e-01 0.511 0 0
Calnexin/calreticulin cycle R-HSA-901042 4.143518e-01 0.383 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.923082e-01 0.406 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.984675e-01 0.400 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.246565e-01 0.372 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.460225e-01 0.461 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.358725e-01 0.474 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.885900e-01 0.411 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.376092e-01 0.624 0 0
RET signaling R-HSA-8853659 3.165505e-01 0.500 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.663058e-01 0.436 0 0
Defective pyroptosis R-HSA-9710421 3.549378e-01 0.450 0 0
Base Excision Repair R-HSA-73884 3.162707e-01 0.500 0 0
PKR-mediated signaling R-HSA-9833482 3.404200e-01 0.468 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.343206e-01 0.476 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.358725e-01 0.474 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.949574e-01 0.530 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.527085e-01 0.597 0 0
Signaling by ALK R-HSA-201556 3.827695e-01 0.417 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.489551e-01 0.457 0 0
Diseases of DNA repair R-HSA-9675135 4.174716e-01 0.379 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.605341e-01 0.443 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.194610e-01 0.659 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.194610e-01 0.659 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.837884e-01 0.547 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.203273e-01 0.657 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.504153e-01 0.455 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.838931e-01 0.416 0 0
Depyrimidination R-HSA-73928 2.203273e-01 0.657 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.050668e-01 0.392 0 0
Sensory processing of sound R-HSA-9659379 3.250363e-01 0.488 0 0
Signaling by ERBB4 R-HSA-1236394 3.456539e-01 0.461 0 0
Cleavage of the damaged purine R-HSA-110331 3.384355e-01 0.471 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 3.722171e-01 0.429 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.827695e-01 0.417 0 0
Depurination R-HSA-73927 3.605341e-01 0.443 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 3.838931e-01 0.416 0 0
SARS-CoV Infections R-HSA-9679506 3.099016e-01 0.509 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.611728e-01 0.583 0 0
IRE1alpha activates chaperones R-HSA-381070 2.588984e-01 0.587 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.169593e-01 0.499 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.246565e-01 0.372 0 0
Gene Silencing by RNA R-HSA-211000 2.518922e-01 0.599 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.194610e-01 0.659 0 0
Metabolism of polyamines R-HSA-351202 3.218533e-01 0.492 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.359157e-01 0.361 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.359157e-01 0.361 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.359157e-01 0.361 0 0
Kinesins R-HSA-983189 4.375521e-01 0.359 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.383085e-01 0.358 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.383422e-01 0.358 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.383422e-01 0.358 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.404683e-01 0.356 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.404683e-01 0.356 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 4.404683e-01 0.356 0 0
Recycling of eIF2:GDP R-HSA-72731 4.404683e-01 0.356 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 4.404683e-01 0.356 0 0
SOS-mediated signalling R-HSA-112412 4.404683e-01 0.356 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.404683e-01 0.356 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 4.404683e-01 0.356 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.404683e-01 0.356 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.404683e-01 0.356 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.404683e-01 0.356 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 4.404683e-01 0.356 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 4.404683e-01 0.356 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.404683e-01 0.356 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 4.404683e-01 0.356 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.478535e-01 0.349 0 0
Translation of Structural Proteins R-HSA-9683701 4.495609e-01 0.347 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.499844e-01 0.347 0 0
GAB1 signalosome R-HSA-180292 4.499844e-01 0.347 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.499844e-01 0.347 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.500761e-01 0.347 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 4.500761e-01 0.347 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.500761e-01 0.347 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.500761e-01 0.347 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.500761e-01 0.347 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.500761e-01 0.347 0 0
Defective DHDDS causes RP59 R-HSA-4755609 4.500761e-01 0.347 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.500761e-01 0.347 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.500761e-01 0.347 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.500761e-01 0.347 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.500761e-01 0.347 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.500761e-01 0.347 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 4.500761e-01 0.347 0 0
C6 deamination of adenosine R-HSA-75102 4.500761e-01 0.347 0 0
Signalling to ERK5 R-HSA-198765 4.500761e-01 0.347 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 4.500761e-01 0.347 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.500761e-01 0.347 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.506747e-01 0.346 0 0
Opioid Signalling R-HSA-111885 4.542965e-01 0.343 0 0
PLC beta mediated events R-HSA-112043 4.562393e-01 0.341 0 0
Protein folding R-HSA-391251 4.572213e-01 0.340 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.599145e-01 0.337 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.599145e-01 0.337 0 0
FLT3 signaling in disease R-HSA-9682385 4.621087e-01 0.335 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.649916e-01 0.333 0 0
Frs2-mediated activation R-HSA-170968 4.667529e-01 0.331 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.667529e-01 0.331 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.667529e-01 0.331 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.667529e-01 0.331 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 4.667529e-01 0.331 0 0
Maturation of nucleoprotein R-HSA-9683610 4.667529e-01 0.331 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.689438e-01 0.329 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.781449e-01 0.320 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.797824e-01 0.319 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.802059e-01 0.319 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.821985e-01 0.317 0 0
E2F mediated regulation of DNA replication R-HSA-113510 4.821985e-01 0.317 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.821985e-01 0.317 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.821985e-01 0.317 0 0
Rap1 signalling R-HSA-392517 4.821985e-01 0.317 0 0
Maturation of nucleoprotein R-HSA-9694631 4.821985e-01 0.317 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.893065e-01 0.310 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.893065e-01 0.310 0 0
MET receptor recycling R-HSA-8875656 4.893065e-01 0.310 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.893065e-01 0.310 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.893065e-01 0.310 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.893065e-01 0.310 0 0
Interleukin-9 signaling R-HSA-8985947 4.893065e-01 0.310 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 4.893065e-01 0.310 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.893065e-01 0.310 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.893065e-01 0.310 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.893065e-01 0.310 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.931917e-01 0.307 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 4.931917e-01 0.307 0 0
Signaling by FGFR4 R-HSA-5654743 4.934777e-01 0.307 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.018008e-01 0.299 0 0
Removal of the Flap Intermediate R-HSA-69166 5.041537e-01 0.297 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.041537e-01 0.297 0 0
Regulation of KIT signaling R-HSA-1433559 5.041537e-01 0.297 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 5.136361e-01 0.289 0 0
Formation of definitive endoderm R-HSA-9823730 5.136361e-01 0.289 0 0
Signaling by NODAL R-HSA-1181150 5.136361e-01 0.289 0 0
Creatine metabolism R-HSA-71288 5.136361e-01 0.289 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.150679e-01 0.288 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.206979e-01 0.283 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.208226e-01 0.283 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.208226e-01 0.283 0 0
Neddylation R-HSA-8951664 5.242397e-01 0.280 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.253232e-01 0.280 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.264474e-01 0.279 0 0
PLC-gamma1 signalling R-HSA-167021 5.264474e-01 0.279 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.264474e-01 0.279 0 0
Classical Kir channels R-HSA-1296053 5.264474e-01 0.279 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 5.264474e-01 0.279 0 0
MET activates PTPN11 R-HSA-8865999 5.264474e-01 0.279 0 0
Inhibition of nitric oxide production R-HSA-9636249 5.264474e-01 0.279 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 5.264474e-01 0.279 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.264474e-01 0.279 0 0
Histamine receptors R-HSA-390650 5.264474e-01 0.279 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.267320e-01 0.278 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.267320e-01 0.278 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.267320e-01 0.278 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.267320e-01 0.278 0 0
Viral Infection Pathways R-HSA-9824446 5.301665e-01 0.276 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.318228e-01 0.274 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.329740e-01 0.273 0 0
Lipophagy R-HSA-9613354 5.353752e-01 0.271 0 0
WNT mediated activation of DVL R-HSA-201688 5.353752e-01 0.271 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 5.353752e-01 0.271 0 0
Interleukin-21 signaling R-HSA-9020958 5.353752e-01 0.271 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.353752e-01 0.271 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.353752e-01 0.271 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.353752e-01 0.271 0 0
Interleukin-1 processing R-HSA-448706 5.353752e-01 0.271 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.353752e-01 0.271 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.353752e-01 0.271 0 0
Signaling by FGFR3 R-HSA-5654741 5.363402e-01 0.271 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.401503e-01 0.267 0 0
DNA Damage Reversal R-HSA-73942 5.401503e-01 0.267 0 0
G-protein activation R-HSA-202040 5.441624e-01 0.264 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 5.441624e-01 0.264 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.441624e-01 0.264 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.441624e-01 0.264 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.441624e-01 0.264 0 0
Regulation of beta-cell development R-HSA-186712 5.441901e-01 0.264 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.477865e-01 0.261 0 0
Cristae formation R-HSA-8949613 5.477865e-01 0.261 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.477865e-01 0.261 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.477865e-01 0.261 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.477865e-01 0.261 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.511393e-01 0.259 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.511393e-01 0.259 0 0
Regulation of pyruvate metabolism R-HSA-9861718 5.572459e-01 0.254 0 0
G-protein mediated events R-HSA-112040 5.653338e-01 0.248 0 0
Amyloid fiber formation R-HSA-977225 5.702054e-01 0.244 0 0
Assembly Of The HIV Virion R-HSA-175474 5.736670e-01 0.241 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.736670e-01 0.241 0 0
Telomere Extension By Telomerase R-HSA-171319 5.739999e-01 0.241 0 0
HIV elongation arrest and recovery R-HSA-167287 5.739999e-01 0.241 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.739999e-01 0.241 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.739999e-01 0.241 0 0
Activation of SMO R-HSA-5635838 5.745927e-01 0.241 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.745927e-01 0.241 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.745927e-01 0.241 0 0
Killing mechanisms R-HSA-9664420 5.745927e-01 0.241 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.749569e-01 0.240 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.749569e-01 0.240 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 5.785018e-01 0.238 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.785018e-01 0.238 0 0
Formation of apoptosome R-HSA-111458 5.785018e-01 0.238 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.785018e-01 0.238 0 0
PI3K/AKT activation R-HSA-198203 5.785018e-01 0.238 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.785018e-01 0.238 0 0
Signal attenuation R-HSA-74749 5.785018e-01 0.238 0 0
Interleukin-27 signaling R-HSA-9020956 5.785018e-01 0.238 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.785018e-01 0.238 0 0
Signaling by Leptin R-HSA-2586552 5.785018e-01 0.238 0 0
Disorders of transmembrane transporters R-HSA-5619115 5.794200e-01 0.237 0 0
Glucose metabolism R-HSA-70326 5.831036e-01 0.234 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.922164e-01 0.228 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.922164e-01 0.228 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.922164e-01 0.228 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.922164e-01 0.228 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 5.922164e-01 0.228 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 5.922164e-01 0.228 0 0
Regulation of gap junction activity R-HSA-191650 5.922164e-01 0.228 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.922164e-01 0.228 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.922164e-01 0.228 0 0
Alanine metabolism R-HSA-8964540 5.922164e-01 0.228 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.922164e-01 0.228 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.922164e-01 0.228 0 0
Sensory perception of sour taste R-HSA-9729555 5.922164e-01 0.228 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.922164e-01 0.228 0 0
Dopamine receptors R-HSA-390651 5.922164e-01 0.228 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.945439e-01 0.226 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.976941e-01 0.224 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.976941e-01 0.224 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.993042e-01 0.222 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.993925e-01 0.222 0 0
Platelet calcium homeostasis R-HSA-418360 5.993925e-01 0.222 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.993925e-01 0.222 0 0
FGFR2 alternative splicing R-HSA-6803529 6.020621e-01 0.220 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.020621e-01 0.220 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.041051e-01 0.219 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.053168e-01 0.218 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 6.073747e-01 0.217 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.073747e-01 0.217 0 0
Potential therapeutics for SARS R-HSA-9679191 6.154628e-01 0.211 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.164436e-01 0.210 0 0
Signaling by FGFR1 R-HSA-5654736 6.166933e-01 0.210 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.185638e-01 0.209 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.186149e-01 0.209 0 0
Signaling by APC mutants R-HSA-4839744 6.186149e-01 0.209 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 6.186149e-01 0.209 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 6.186149e-01 0.209 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 6.186149e-01 0.209 0 0
Formation of the posterior neural plate R-HSA-9832991 6.186149e-01 0.209 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 6.186149e-01 0.209 0 0
Suppression of apoptosis R-HSA-9635465 6.186149e-01 0.209 0 0
Prostanoid ligand receptors R-HSA-391908 6.186149e-01 0.209 0 0
ChREBP activates metabolic gene expression R-HSA-163765 6.186149e-01 0.209 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 6.186149e-01 0.209 0 0
RUNX2 regulates bone development R-HSA-8941326 6.206051e-01 0.207 0 0
DAP12 signaling R-HSA-2424491 6.239075e-01 0.205 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.239075e-01 0.205 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.239075e-01 0.205 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.239075e-01 0.205 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.277884e-01 0.202 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.292810e-01 0.201 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.292810e-01 0.201 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.292810e-01 0.201 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.324601e-01 0.199 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.325197e-01 0.199 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.384275e-01 0.195 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.384275e-01 0.195 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.384275e-01 0.195 0 0
Downstream signal transduction R-HSA-186763 6.474997e-01 0.189 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.488544e-01 0.188 0 0
Defective F9 activation R-HSA-9673221 6.488544e-01 0.188 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.488544e-01 0.188 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 6.488544e-01 0.188 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 6.488544e-01 0.188 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.488544e-01 0.188 0 0
Activation of AKT2 R-HSA-165158 6.488544e-01 0.188 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 6.488544e-01 0.188 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.488544e-01 0.188 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.488544e-01 0.188 0 0
Reelin signalling pathway R-HSA-8866376 6.488544e-01 0.188 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.488544e-01 0.188 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.488544e-01 0.188 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.488544e-01 0.188 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.488544e-01 0.188 0 0
NrCAM interactions R-HSA-447038 6.488544e-01 0.188 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.488544e-01 0.188 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.488544e-01 0.188 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.488544e-01 0.188 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 6.488544e-01 0.188 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.552758e-01 0.184 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.552758e-01 0.184 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.552758e-01 0.184 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 6.552758e-01 0.184 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.552758e-01 0.184 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.557197e-01 0.183 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.557197e-01 0.183 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.557197e-01 0.183 0 0
Signaling by AXIN mutants R-HSA-4839735 6.557197e-01 0.183 0 0
Macroautophagy R-HSA-1632852 6.590995e-01 0.181 0 0
Signaling by FGFR2 R-HSA-5654738 6.628429e-01 0.179 0 0
Signaling by MET R-HSA-6806834 6.628429e-01 0.179 0 0
MET promotes cell motility R-HSA-8875878 6.633249e-01 0.178 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.633249e-01 0.178 0 0
PKA activation R-HSA-163615 6.677149e-01 0.175 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.677149e-01 0.175 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.677149e-01 0.175 0 0
Apoptotic factor-mediated response R-HSA-111471 6.677149e-01 0.175 0 0
Peroxisomal protein import R-HSA-9033241 6.693207e-01 0.174 0 0
HCMV Early Events R-HSA-9609690 6.720322e-01 0.173 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.728362e-01 0.172 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.728362e-01 0.172 0 0
Post NMDA receptor activation events R-HSA-438064 6.757207e-01 0.170 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.774244e-01 0.169 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.774244e-01 0.169 0 0
Signaling by FGFR in disease R-HSA-1226099 6.796998e-01 0.168 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.800158e-01 0.167 0 0
Interleukin-7 signaling R-HSA-1266695 6.800158e-01 0.167 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.800158e-01 0.167 0 0
Autophagy R-HSA-9612973 6.807955e-01 0.167 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.835118e-01 0.165 0 0
RAS processing R-HSA-9648002 6.835118e-01 0.165 0 0
Repression of WNT target genes R-HSA-4641265 6.898778e-01 0.161 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.898778e-01 0.161 0 0
Scavenging by Class F Receptors R-HSA-3000484 6.898778e-01 0.161 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 6.898778e-01 0.161 0 0
Interleukin-35 Signalling R-HSA-8984722 6.898778e-01 0.161 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 6.898778e-01 0.161 0 0
Regulation of IFNG signaling R-HSA-877312 6.898778e-01 0.161 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.898778e-01 0.161 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.901977e-01 0.161 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.901977e-01 0.161 0 0
HCMV Late Events R-HSA-9610379 6.910838e-01 0.160 0 0
Integrin signaling R-HSA-354192 6.917923e-01 0.160 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.952278e-01 0.158 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.952278e-01 0.158 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.952278e-01 0.158 0 0
Other interleukin signaling R-HSA-449836 6.952278e-01 0.158 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 6.952278e-01 0.158 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.976286e-01 0.156 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.976286e-01 0.156 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.976286e-01 0.156 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.976286e-01 0.156 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.976286e-01 0.156 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.976286e-01 0.156 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.976286e-01 0.156 0 0
Threonine catabolism R-HSA-8849175 6.976286e-01 0.156 0 0
PDE3B signalling R-HSA-165160 6.976286e-01 0.156 0 0
PKB-mediated events R-HSA-109703 6.976286e-01 0.156 0 0
Synthesis of PS R-HSA-1483101 6.976286e-01 0.156 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.976286e-01 0.156 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.976286e-01 0.156 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.976286e-01 0.156 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 6.976286e-01 0.156 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.976286e-01 0.156 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.976286e-01 0.156 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.978256e-01 0.156 0 0
MAP kinase activation R-HSA-450294 7.019071e-01 0.154 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.028913e-01 0.153 0 0
HIV Transcription Elongation R-HSA-167169 7.028913e-01 0.153 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.028913e-01 0.153 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.034856e-01 0.153 0 0
Stimuli-sensing channels R-HSA-2672351 7.092459e-01 0.149 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.190635e-01 0.143 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.209801e-01 0.142 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.209801e-01 0.142 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.209801e-01 0.142 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.209801e-01 0.142 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.211920e-01 0.142 0 0
FGFR1c ligand binding and activation R-HSA-190373 7.211920e-01 0.142 0 0
CD28 dependent Vav1 pathway R-HSA-389359 7.211920e-01 0.142 0 0
Interleukin-6 signaling R-HSA-1059683 7.211920e-01 0.142 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 7.211920e-01 0.142 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.211920e-01 0.142 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.256829e-01 0.139 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.256829e-01 0.139 0 0
GPER1 signaling R-HSA-9634597 7.302265e-01 0.137 0 0
Co-stimulation by CD28 R-HSA-389356 7.302265e-01 0.137 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.339288e-01 0.134 0 0
Integrin cell surface interactions R-HSA-216083 7.363258e-01 0.133 0 0
Ion homeostasis R-HSA-5578775 7.386856e-01 0.132 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.396305e-01 0.131 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.396305e-01 0.131 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.396305e-01 0.131 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 7.396305e-01 0.131 0 0
Lactose synthesis R-HSA-5653890 7.396305e-01 0.131 0 0
Metabolism of vitamin K R-HSA-6806664 7.396305e-01 0.131 0 0
Nef and signal transduction R-HSA-164944 7.396305e-01 0.131 0 0
Leukotriene receptors R-HSA-391906 7.396305e-01 0.131 0 0
CREB3 factors activate genes R-HSA-8874211 7.396305e-01 0.131 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.422222e-01 0.129 0 0
ERK/MAPK targets R-HSA-198753 7.450038e-01 0.128 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.450038e-01 0.128 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.450038e-01 0.128 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.466168e-01 0.127 0 0
Pyrimidine salvage R-HSA-73614 7.466168e-01 0.127 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.495211e-01 0.125 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.495211e-01 0.125 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.495211e-01 0.125 0 0
Regulation of insulin secretion R-HSA-422356 7.495211e-01 0.125 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.497931e-01 0.125 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.497931e-01 0.125 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.497931e-01 0.125 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.497931e-01 0.125 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.497931e-01 0.125 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 7.497931e-01 0.125 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.497931e-01 0.125 0 0
Zinc transporters R-HSA-435354 7.497931e-01 0.125 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.497931e-01 0.125 0 0
Signalling to ERKs R-HSA-187687 7.507905e-01 0.124 0 0
Rab regulation of trafficking R-HSA-9007101 7.517845e-01 0.124 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.545714e-01 0.122 0 0
Activation of GABAB receptors R-HSA-991365 7.561057e-01 0.121 0 0
GABA B receptor activation R-HSA-977444 7.561057e-01 0.121 0 0
tRNA processing R-HSA-72306 7.563519e-01 0.121 0 0
Reproduction R-HSA-1474165 7.572481e-01 0.121 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.649923e-01 0.116 0 0
Signaling by Erythropoietin R-HSA-9006335 7.663064e-01 0.116 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.663064e-01 0.116 0 0
Glucagon-type ligand receptors R-HSA-420092 7.663064e-01 0.116 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.673459e-01 0.115 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.681417e-01 0.115 0 0
Developmental Cell Lineages R-HSA-9734767 7.684688e-01 0.114 0 0
GPVI-mediated activation cascade R-HSA-114604 7.684733e-01 0.114 0 0
Signaling by SCF-KIT R-HSA-1433557 7.722030e-01 0.112 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.758000e-01 0.110 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 7.758000e-01 0.110 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.758000e-01 0.110 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.758000e-01 0.110 0 0
Disinhibition of SNARE formation R-HSA-114516 7.758000e-01 0.110 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.758000e-01 0.110 0 0
PTK6 Expression R-HSA-8849473 7.758000e-01 0.110 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.758000e-01 0.110 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.758000e-01 0.110 0 0
Reuptake of GABA R-HSA-888593 7.758000e-01 0.110 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.758000e-01 0.110 0 0
VLDL clearance R-HSA-8964046 7.758000e-01 0.110 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.758000e-01 0.110 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.758000e-01 0.110 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.758000e-01 0.110 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.758306e-01 0.110 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.758306e-01 0.110 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.758306e-01 0.110 0 0
DCC mediated attractive signaling R-HSA-418885 7.758306e-01 0.110 0 0
Signaling by Activin R-HSA-1502540 7.758306e-01 0.110 0 0
Other semaphorin interactions R-HSA-416700 7.758306e-01 0.110 0 0
Formation of the anterior neural plate R-HSA-9823739 7.758306e-01 0.110 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.800171e-01 0.108 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.847788e-01 0.105 0 0
Protein localization R-HSA-9609507 7.871349e-01 0.104 0 0
Netrin-1 signaling R-HSA-373752 7.874920e-01 0.104 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.880646e-01 0.103 0 0
LDL clearance R-HSA-8964038 7.880646e-01 0.103 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.887481e-01 0.103 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.908460e-01 0.102 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.927621e-01 0.101 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.947679e-01 0.100 0 0
Neutrophil degranulation R-HSA-6798695 7.964693e-01 0.099 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.985221e-01 0.098 0 0
Regulated Necrosis R-HSA-5218859 7.990662e-01 0.097 0 0
Phase 4 - resting membrane potential R-HSA-5576886 7.994646e-01 0.097 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 7.994646e-01 0.097 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 7.994646e-01 0.097 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.994646e-01 0.097 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.994646e-01 0.097 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 7.994646e-01 0.097 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.009435e-01 0.096 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.019857e-01 0.096 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 8.069468e-01 0.093 0 0
RSK activation R-HSA-444257 8.069468e-01 0.093 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 8.069468e-01 0.093 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 8.069468e-01 0.093 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 8.069468e-01 0.093 0 0
Adrenoceptors R-HSA-390696 8.069468e-01 0.093 0 0
SLC-mediated bile acid transport R-HSA-9958517 8.069468e-01 0.093 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 8.069468e-01 0.093 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 8.069468e-01 0.093 0 0
Alpha-defensins R-HSA-1462054 8.069468e-01 0.093 0 0
Sodium/Proton exchangers R-HSA-425986 8.069468e-01 0.093 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.072270e-01 0.093 0 0
Growth hormone receptor signaling R-HSA-982772 8.072270e-01 0.093 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.107905e-01 0.091 0 0
Translation of Structural Proteins R-HSA-9694635 8.145426e-01 0.089 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.157005e-01 0.088 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.157005e-01 0.088 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.157749e-01 0.088 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.182128e-01 0.087 0 0
Signaling by WNT in cancer R-HSA-4791275 8.182128e-01 0.087 0 0
Signaling by PDGF R-HSA-186797 8.192350e-01 0.087 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.208603e-01 0.086 0 0
Fibronectin matrix formation R-HSA-1566977 8.208603e-01 0.086 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.208603e-01 0.086 0 0
Interleukin-17 signaling R-HSA-448424 8.219908e-01 0.085 0 0
Complex III assembly R-HSA-9865881 8.249062e-01 0.084 0 0
Signaling by FGFR R-HSA-190236 8.264310e-01 0.083 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 8.332570e-01 0.079 0 0
MAPK1 (ERK2) activation R-HSA-112411 8.337681e-01 0.079 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 8.337681e-01 0.079 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.337681e-01 0.079 0 0
mRNA Editing R-HSA-75072 8.337681e-01 0.079 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.337681e-01 0.079 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 8.337681e-01 0.079 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.337681e-01 0.079 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.337681e-01 0.079 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.337681e-01 0.079 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.337681e-01 0.079 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.337681e-01 0.079 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.351901e-01 0.078 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.384658e-01 0.077 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.401835e-01 0.076 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.401835e-01 0.076 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.401835e-01 0.076 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.401835e-01 0.076 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.411793e-01 0.075 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.411793e-01 0.075 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.411793e-01 0.075 0 0
Hyaluronan degradation R-HSA-2160916 8.411793e-01 0.075 0 0
Pyruvate metabolism R-HSA-70268 8.471276e-01 0.072 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.472471e-01 0.072 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.472471e-01 0.072 0 0
Intra-Golgi traffic R-HSA-6811438 8.549911e-01 0.068 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.561259e-01 0.067 0 0
TRP channels R-HSA-3295583 8.561259e-01 0.067 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 8.568644e-01 0.067 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.568644e-01 0.067 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.568644e-01 0.067 0 0
CASP4 inflammasome assembly R-HSA-9948001 8.568644e-01 0.067 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.568644e-01 0.067 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.568644e-01 0.067 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.568644e-01 0.067 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.568644e-01 0.067 0 0
Tandem pore domain potassium channels R-HSA-1296346 8.568644e-01 0.067 0 0
Maturation of spike protein R-HSA-9683686 8.568644e-01 0.067 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.575968e-01 0.067 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.575968e-01 0.067 0 0
PKA activation in glucagon signalling R-HSA-164378 8.575968e-01 0.067 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 8.575968e-01 0.067 0 0
Nephron development R-HSA-9831926 8.575968e-01 0.067 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 8.575968e-01 0.067 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.602318e-01 0.065 0 0
Hyaluronan metabolism R-HSA-2142845 8.602318e-01 0.065 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.602318e-01 0.065 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.602318e-01 0.065 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.616656e-01 0.065 0 0
PI3K Cascade R-HSA-109704 8.631842e-01 0.064 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.631842e-01 0.064 0 0
HCMV Infection R-HSA-9609646 8.632310e-01 0.064 0 0
Signaling by BMP R-HSA-201451 8.698262e-01 0.061 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 8.698262e-01 0.061 0 0
Insulin processing R-HSA-264876 8.698262e-01 0.061 0 0
Iron uptake and transport R-HSA-917937 8.704904e-01 0.060 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.713158e-01 0.060 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.722612e-01 0.059 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.722612e-01 0.059 0 0
Pyrimidine biosynthesis R-HSA-500753 8.732579e-01 0.059 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.732579e-01 0.059 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.732579e-01 0.059 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.732579e-01 0.059 0 0
Specification of the neural plate border R-HSA-9834899 8.732579e-01 0.059 0 0
Diseases of hemostasis R-HSA-9671793 8.732579e-01 0.059 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.732579e-01 0.059 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.735283e-01 0.059 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.767529e-01 0.057 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.767529e-01 0.057 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.767529e-01 0.057 0 0
Interleukin-2 signaling R-HSA-9020558 8.767529e-01 0.057 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.767529e-01 0.057 0 0
vRNP Assembly R-HSA-192905 8.767529e-01 0.057 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.767529e-01 0.057 0 0
Synthesis of PI R-HSA-1483226 8.767529e-01 0.057 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.767529e-01 0.057 0 0
Bicarbonate transporters R-HSA-425381 8.767529e-01 0.057 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.767529e-01 0.057 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.767529e-01 0.057 0 0
Transcription of the HIV genome R-HSA-167172 8.791612e-01 0.056 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.791772e-01 0.056 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.812205e-01 0.055 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.815552e-01 0.055 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.823603e-01 0.054 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.823603e-01 0.054 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.823603e-01 0.054 0 0
Pyroptosis R-HSA-5620971 8.823603e-01 0.054 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.828398e-01 0.054 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.833861e-01 0.054 0 0
DAP12 interactions R-HSA-2172127 8.869848e-01 0.052 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.873174e-01 0.052 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.873174e-01 0.052 0 0
Aquaporin-mediated transport R-HSA-445717 8.889491e-01 0.051 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.913884e-01 0.050 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.913884e-01 0.050 0 0
Nucleotide biosynthesis R-HSA-8956320 8.917387e-01 0.050 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.936572e-01 0.049 0 0
Collagen chain trimerization R-HSA-8948216 8.936572e-01 0.049 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.937772e-01 0.049 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.938788e-01 0.049 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.938788e-01 0.049 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.938788e-01 0.049 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.938788e-01 0.049 0 0
Plasmalogen biosynthesis R-HSA-75896 8.938788e-01 0.049 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.938788e-01 0.049 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.938788e-01 0.049 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.938788e-01 0.049 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.938788e-01 0.049 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.938788e-01 0.049 0 0
Anchoring fibril formation R-HSA-2214320 8.938788e-01 0.049 0 0
Activation of RAC1 R-HSA-428540 8.938788e-01 0.049 0 0
Sodium/Calcium exchangers R-HSA-425561 8.938788e-01 0.049 0 0
DS-GAG biosynthesis R-HSA-2022923 8.938788e-01 0.049 0 0
COPII-mediated vesicle transport R-HSA-204005 8.950762e-01 0.048 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.042427e-01 0.044 0 0
G alpha (z) signalling events R-HSA-418597 9.078170e-01 0.042 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.081891e-01 0.042 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.081891e-01 0.042 0 0
Interleukin-15 signaling R-HSA-8983432 9.086259e-01 0.042 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 9.086259e-01 0.042 0 0
GRB2 events in EGFR signaling R-HSA-179812 9.086259e-01 0.042 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 9.086259e-01 0.042 0 0
Signaling by LTK R-HSA-9842663 9.086259e-01 0.042 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 9.086259e-01 0.042 0 0
OAS antiviral response R-HSA-8983711 9.086259e-01 0.042 0 0
Vesicle-mediated transport R-HSA-5653656 9.100668e-01 0.041 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.111935e-01 0.040 0 0
Pentose phosphate pathway R-HSA-71336 9.118392e-01 0.040 0 0
Interferon alpha/beta signaling R-HSA-909733 9.126870e-01 0.040 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.137417e-01 0.039 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.137417e-01 0.039 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.139199e-01 0.039 0 0
Integration of energy metabolism R-HSA-163685 9.149492e-01 0.039 0 0
SLC transporter disorders R-HSA-5619102 9.193771e-01 0.037 0 0
Interleukin-2 family signaling R-HSA-451927 9.198478e-01 0.036 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.198478e-01 0.036 0 0
Diseases of Immune System R-HSA-5260271 9.198478e-01 0.036 0 0
Gluconeogenesis R-HSA-70263 9.200705e-01 0.036 0 0
Metal ion SLC transporters R-HSA-425410 9.200705e-01 0.036 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.212688e-01 0.036 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.212688e-01 0.036 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.212688e-01 0.036 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.212688e-01 0.036 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.212688e-01 0.036 0 0
Signaling by KIT in disease R-HSA-9669938 9.212688e-01 0.036 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 9.213243e-01 0.036 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.213243e-01 0.036 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 9.213243e-01 0.036 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.213243e-01 0.036 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.213243e-01 0.036 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.213243e-01 0.036 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.213243e-01 0.036 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.213243e-01 0.036 0 0
IRS-mediated signalling R-HSA-112399 9.217869e-01 0.035 0 0
Mitochondrial biogenesis R-HSA-1592230 9.224949e-01 0.035 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.236643e-01 0.034 0 0
Neurotransmitter release cycle R-HSA-112310 9.239582e-01 0.034 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.253308e-01 0.034 0 0
Toll-like Receptor Cascades R-HSA-168898 9.268234e-01 0.033 0 0
Gap junction trafficking and regulation R-HSA-157858 9.268708e-01 0.033 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.271978e-01 0.033 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.302597e-01 0.031 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.302597e-01 0.031 0 0
Adaptive Immune System R-HSA-1280218 9.317731e-01 0.031 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.322587e-01 0.030 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.322587e-01 0.030 0 0
Prolactin receptor signaling R-HSA-1170546 9.322587e-01 0.030 0 0
Signal regulatory protein family interactions R-HSA-391160 9.322587e-01 0.030 0 0
Physiological factors R-HSA-5578768 9.322587e-01 0.030 0 0
Malate-aspartate shuttle R-HSA-9856872 9.322587e-01 0.030 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.322587e-01 0.030 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.322587e-01 0.030 0 0
P2Y receptors R-HSA-417957 9.322587e-01 0.030 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.339343e-01 0.030 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.373117e-01 0.028 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.382730e-01 0.028 0 0
Interleukin-6 family signaling R-HSA-6783589 9.382730e-01 0.028 0 0
GABA receptor activation R-HSA-977443 9.392607e-01 0.027 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.399965e-01 0.027 0 0
Erythropoietin activates RAS R-HSA-9027284 9.416740e-01 0.026 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.416740e-01 0.026 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.416740e-01 0.026 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.416740e-01 0.026 0 0
Protein repair R-HSA-5676934 9.416740e-01 0.026 0 0
Protein lipoylation R-HSA-9857492 9.416740e-01 0.026 0 0
Biotin transport and metabolism R-HSA-196780 9.416740e-01 0.026 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.416740e-01 0.026 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.416740e-01 0.026 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.416740e-01 0.026 0 0
eNOS activation R-HSA-203615 9.437396e-01 0.025 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.442601e-01 0.025 0 0
Collagen degradation R-HSA-1442490 9.442601e-01 0.025 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.454065e-01 0.024 0 0
Tight junction interactions R-HSA-420029 9.454065e-01 0.024 0 0
Laminin interactions R-HSA-3000157 9.454065e-01 0.024 0 0
Formation of the nephric duct R-HSA-9830364 9.454065e-01 0.024 0 0
MHC class II antigen presentation R-HSA-2132295 9.465231e-01 0.024 0 0
Cilium Assembly R-HSA-5617833 9.479720e-01 0.023 0 0
Mitochondrial protein import R-HSA-1268020 9.488878e-01 0.023 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.494586e-01 0.023 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.497811e-01 0.022 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 9.497811e-01 0.022 0 0
Fructose catabolism R-HSA-70350 9.497811e-01 0.022 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.497811e-01 0.022 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.497811e-01 0.022 0 0
Differentiation of T cells R-HSA-9945266 9.497811e-01 0.022 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 9.497811e-01 0.022 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.497811e-01 0.022 0 0
Attachment and Entry R-HSA-9678110 9.497811e-01 0.022 0 0
Virus Assembly and Release R-HSA-168268 9.497811e-01 0.022 0 0
Gap junction trafficking R-HSA-190828 9.508856e-01 0.022 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.517502e-01 0.021 0 0
MET activates PTK2 signaling R-HSA-8874081 9.517502e-01 0.021 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.517502e-01 0.021 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.547980e-01 0.020 0 0
Glycosphingolipid transport R-HSA-9845576 9.547980e-01 0.020 0 0
Triglyceride catabolism R-HSA-163560 9.547980e-01 0.020 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 9.567617e-01 0.019 0 0
Heme assimilation R-HSA-9927020 9.567617e-01 0.019 0 0
Passive transport by Aquaporins R-HSA-432047 9.567617e-01 0.019 0 0
Synthesis of PG R-HSA-1483148 9.567617e-01 0.019 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.567617e-01 0.019 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.567617e-01 0.019 0 0
Potassium Channels R-HSA-1296071 9.570668e-01 0.019 0 0
IGF1R signaling cascade R-HSA-2428924 9.571197e-01 0.019 0 0
Insulin receptor signalling cascade R-HSA-74751 9.571197e-01 0.019 0 0
Ion transport by P-type ATPases R-HSA-936837 9.571197e-01 0.019 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.573856e-01 0.019 0 0
Triglyceride biosynthesis R-HSA-75109 9.573856e-01 0.019 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.573856e-01 0.019 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.574978e-01 0.019 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.607674e-01 0.017 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.623870e-01 0.017 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.627724e-01 0.016 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.627724e-01 0.016 0 0
Choline catabolism R-HSA-6798163 9.627724e-01 0.016 0 0
Specification of primordial germ cells R-HSA-9827857 9.627724e-01 0.016 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.630174e-01 0.016 0 0
Elastic fibre formation R-HSA-1566948 9.637955e-01 0.016 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.637955e-01 0.016 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.638818e-01 0.016 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.641304e-01 0.016 0 0
Ion channel transport R-HSA-983712 9.641932e-01 0.016 0 0
Interferon gamma signaling R-HSA-877300 9.664949e-01 0.015 0 0
mRNA Capping R-HSA-72086 9.668218e-01 0.015 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.672279e-01 0.014 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.679478e-01 0.014 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.679478e-01 0.014 0 0
Platelet sensitization by LDL R-HSA-432142 9.679478e-01 0.014 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.679478e-01 0.014 0 0
Tie2 Signaling R-HSA-210993 9.679478e-01 0.014 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.679478e-01 0.014 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.683414e-01 0.014 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.683616e-01 0.014 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.695915e-01 0.013 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.710856e-01 0.013 0 0
Triglyceride metabolism R-HSA-8979227 9.712612e-01 0.013 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.721255e-01 0.012 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.722665e-01 0.012 0 0
Mitochondrial protein degradation R-HSA-9837999 9.722665e-01 0.012 0 0
Cardiac conduction R-HSA-5576891 9.723930e-01 0.012 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.724039e-01 0.012 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.724039e-01 0.012 0 0
Azathioprine ADME R-HSA-9748787 9.734250e-01 0.012 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.762408e-01 0.010 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.762408e-01 0.010 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.762408e-01 0.010 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.762408e-01 0.010 0 0
Hemostasis R-HSA-109582 9.767613e-01 0.010 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.769698e-01 0.010 0 0
HIV Transcription Initiation R-HSA-167161 9.769698e-01 0.010 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.769698e-01 0.010 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.769698e-01 0.010 0 0
Transmission across Chemical Synapses R-HSA-112315 9.781279e-01 0.010 0 0
RSV-host interactions R-HSA-9833110 9.784587e-01 0.009 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.794658e-01 0.009 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.795444e-01 0.009 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.795444e-01 0.009 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.795444e-01 0.009 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.795444e-01 0.009 0 0
Phenylalanine metabolism R-HSA-8964208 9.795444e-01 0.009 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.795444e-01 0.009 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.795444e-01 0.009 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.811999e-01 0.008 0 0
Phospholipid metabolism R-HSA-1483257 9.813389e-01 0.008 0 0
Platelet homeostasis R-HSA-418346 9.816325e-01 0.008 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.817024e-01 0.008 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.823888e-01 0.008 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.823888e-01 0.008 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.823888e-01 0.008 0 0
Serine metabolism R-HSA-977347 9.823888e-01 0.008 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.823888e-01 0.008 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.823888e-01 0.008 0 0
Attachment and Entry R-HSA-9694614 9.823888e-01 0.008 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.824273e-01 0.008 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.826964e-01 0.008 0 0
Surfactant metabolism R-HSA-5683826 9.837050e-01 0.007 0 0
Amine ligand-binding receptors R-HSA-375280 9.837050e-01 0.007 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.843681e-01 0.007 0 0
RA biosynthesis pathway R-HSA-5365859 9.845479e-01 0.007 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.846289e-01 0.007 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.848378e-01 0.007 0 0
Cellular hexose transport R-HSA-189200 9.848378e-01 0.007 0 0
Fructose metabolism R-HSA-5652084 9.848378e-01 0.007 0 0
Ethanol oxidation R-HSA-71384 9.848378e-01 0.007 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.848378e-01 0.007 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.854967e-01 0.006 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.864187e-01 0.006 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.869464e-01 0.006 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.869464e-01 0.006 0 0
Interleukin-20 family signaling R-HSA-8854691 9.869464e-01 0.006 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.869464e-01 0.006 0 0
Formation of the ureteric bud R-HSA-9830674 9.869464e-01 0.006 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.869464e-01 0.006 0 0
Kidney development R-HSA-9830369 9.870527e-01 0.006 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.870984e-01 0.006 0 0
Collagen formation R-HSA-1474290 9.871111e-01 0.006 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.880681e-01 0.005 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.883124e-01 0.005 0 0
Interleukin-10 signaling R-HSA-6783783 9.883644e-01 0.005 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.885294e-01 0.005 0 0
Synthesis of PC R-HSA-1483191 9.885294e-01 0.005 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.887618e-01 0.005 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.887618e-01 0.005 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.887618e-01 0.005 0 0
Metabolism of folate and pterines R-HSA-196757 9.895215e-01 0.005 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.898847e-01 0.004 0 0
Extracellular matrix organization R-HSA-1474244 9.901625e-01 0.004 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.903249e-01 0.004 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.903249e-01 0.004 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.903249e-01 0.004 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.903249e-01 0.004 0 0
RAB geranylgeranylation R-HSA-8873719 9.909400e-01 0.004 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.909400e-01 0.004 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.909400e-01 0.004 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.912580e-01 0.004 0 0
ECM proteoglycans R-HSA-3000178 9.914309e-01 0.004 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.916706e-01 0.004 0 0
Urea cycle R-HSA-70635 9.916706e-01 0.004 0 0
Sphingolipid catabolism R-HSA-9845614 9.916706e-01 0.004 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.916706e-01 0.004 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.918620e-01 0.004 0 0
Nucleotide salvage R-HSA-8956321 9.918894e-01 0.004 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.927431e-01 0.003 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.928292e-01 0.003 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.928292e-01 0.003 0 0
Synthesis of PE R-HSA-1483213 9.928292e-01 0.003 0 0
The phototransduction cascade R-HSA-2514856 9.928684e-01 0.003 0 0
Signaling by Insulin receptor R-HSA-74752 9.935982e-01 0.003 0 0
Maturation of spike protein R-HSA-9694548 9.937916e-01 0.003 0 0
Insulin receptor recycling R-HSA-77387 9.938268e-01 0.003 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.945579e-01 0.002 0 0
Heme biosynthesis R-HSA-189451 9.945579e-01 0.002 0 0
Neuronal System R-HSA-112316 9.946661e-01 0.002 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.946856e-01 0.002 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.946856e-01 0.002 0 0
Neurotransmitter clearance R-HSA-112311 9.954249e-01 0.002 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.956233e-01 0.002 0 0
PPARA activates gene expression R-HSA-1989781 9.960165e-01 0.002 0 0
Cargo concentration in the ER R-HSA-5694530 9.960615e-01 0.002 0 0
Mitochondrial translation elongation R-HSA-5389840 9.960647e-01 0.002 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.961030e-01 0.002 0 0
Methylation R-HSA-156581 9.963418e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.965509e-01 0.002 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.966067e-01 0.001 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.970813e-01 0.001 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.974874e-01 0.001 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.974874e-01 0.001 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.974874e-01 0.001 0 0
Heme degradation R-HSA-189483 9.974874e-01 0.001 0 0
Leishmania infection R-HSA-9658195 9.975128e-01 0.001 0 0
Parasitic Infection Pathways R-HSA-9824443 9.975128e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.976143e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.976732e-01 0.001 0 0
Gap junction assembly R-HSA-190861 9.978371e-01 0.001 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.978371e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.981240e-01 0.001 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.981381e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.981381e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.983551e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.983599e-01 0.001 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.984477e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.984774e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.985665e-01 0.001 0 0
Voltage gated Potassium channels R-HSA-1296072 9.986203e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.986203e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.986203e-01 0.001 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.986203e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.986560e-01 0.001 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.986865e-01 0.001 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.988124e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.988124e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.989074e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.989376e-01 0.000 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.989777e-01 0.000 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.989777e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.990276e-01 0.000 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.991200e-01 0.000 0 0
Tryptophan catabolism R-HSA-71240 9.991200e-01 0.000 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.991200e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.991653e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.992304e-01 0.000 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.992477e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.993649e-01 0.000 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.993824e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.993983e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.993983e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.994388e-01 0.000 0 0
Defensins R-HSA-1461973 9.995169e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.995716e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.995808e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.995842e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.995893e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.996421e-01 0.000 0 0
Immune System R-HSA-168256 9.996640e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.997071e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.997244e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.997348e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.997541e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.997674e-01 0.000 0 0
Intraflagellar transport R-HSA-5620924 9.997718e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.997838e-01 0.000 0 0
Parasite infection R-HSA-9664407 9.997945e-01 0.000 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.997945e-01 0.000 0 0
Leishmania phagocytosis R-HSA-9664417 9.997945e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.998108e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.998545e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.998545e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998592e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.998812e-01 0.000 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.998922e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.998932e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.998990e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999054e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999070e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.999202e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999295e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999331e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.999409e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999474e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999501e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999501e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999562e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999768e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999769e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999799e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999824e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999848e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999855e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999868e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.999868e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999868e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999879e-01 0.000 0 0
Disease R-HSA-1643685 9.999903e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999916e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999928e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999928e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999934e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999938e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999951e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999954e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999972e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999978e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999983e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999986e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999992e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999996e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999998e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999998e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999998e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999999e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999999e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999999e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999999e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999999e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways