PLK4

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
A6NMY6 S164 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGS
O00444 S179 Sugiyama PLK4 SAK STK18 TQLKMPHEKHytLCGtPNyIsPEIATRSAHGLESDVWSLGC
O00444 S22 EPSD|PSP|Sugiyama PLK4 SAK STK18 ATCIGEKIEDFKVGNLLGKGsFAGVYRAESIHTGLEVAIKM
O00444 S305 SIGNOR|EPSD|PSP PLK4 SAK STK18 SGHATISTAITASSSTSISGsLFDKRRLLIGQPLPNKMTVF
O00444 S401 Sugiyama PLK4 SAK STK18 RSGTSNSQSQAKTYTMERCHsAEMLSVsKRsGGGENEERys
O00444 S408 Sugiyama PLK4 SAK STK18 QSQAKTYTMERCHsAEMLSVsKRsGGGENEERysPtDNNAN
O00444 S411 Sugiyama PLK4 SAK STK18 AKTYTMERCHsAEMLSVsKRsGGGENEERysPtDNNANIFN
O00444 S421 Sugiyama PLK4 SAK STK18 sAEMLSVsKRsGGGENEERysPtDNNANIFNFFKEKTSSSs
O00444 S441 Sugiyama PLK4 SAK STK18 sPtDNNANIFNFFKEKTSSSsGsFERPDNNQALSNHLCPGK
O00444 S443 Sugiyama PLK4 SAK STK18 tDNNANIFNFFKEKTSSSsGsFERPDNNQALSNHLCPGKTP
O00444 S497 Sugiyama PLK4 SAK STK18 QQWFGNLQINAHLRKTTEYDsIsPNRDFQGHPDLQKDTSKN
O00444 S499 Sugiyama PLK4 SAK STK18 WFGNLQINAHLRKTTEYDsIsPNRDFQGHPDLQKDTSKNAW
O00444 S592 Sugiyama PLK4 SAK STK18 KTRGMEPPWGYQNRTLRsItsPLVAHRLKPIRQKTKKAVVS
O00444 S640 Sugiyama PLK4 SAK STK18 CVELVKEYASQEYVKEVLQIsSDGNTItIYYPNGGRGFPLA
O00444 S817 Sugiyama PLK4 SAK STK18 PFFPIIIGRKPGSTSSPKALsPPPsVDsNYPTRERASFNRM
O00444 S821 Sugiyama PLK4 SAK STK18 IIIGRKPGSTSSPKALsPPPsVDsNYPTRERASFNRMVMHS
O00444 S824 Sugiyama PLK4 SAK STK18 GRKPGSTSSPKALsPPPsVDsNYPTRERASFNRMVMHSAAS
O00444 T170 EPSD|PSP|Sugiyama PLK4 SAK STK18 IKIADFGLATQLKMPHEKHytLCGtPNyIsPEIATRSAHGL
O00444 T174 Sugiyama PLK4 SAK STK18 DFGLATQLKMPHEKHytLCGtPNyIsPEIATRSAHGLESDV
O00444 T647 Sugiyama PLK4 SAK STK18 YASQEYVKEVLQIsSDGNTItIYYPNGGRGFPLADRPPsPT
O00444 Y169 Sugiyama PLK4 SAK STK18 NIKIADFGLATQLKMPHEKHytLCGtPNyIsPEIATRSAHG
O00444 Y177 EPSD|PSP|Sugiyama PLK4 SAK STK18 LATQLKMPHEKHytLCGtPNyIsPEIATRSAHGLESDVWSL
O14974 S912 Sugiyama PPP1R12A MBS MYPT1 TssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDSTDF
O43303 S98 EPSD|PSP CCP110 CEP110 CP110 KIAA0419 LLTRVQEILDNVQVRKAPNAsDFDQWEMETVYSNSEVRNLN
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60907 S569 Sugiyama TBL1X TBL1 IFEVCWNARGDKVGASASDGsVCVLDLRK____________
O75643 S26 Sugiyama SNRNP200 ASCC3L1 BRR2 HELIC2 KIAA0788 ARsLQYEYKANsNLVLQADRsLIDRTRRDEPTGEVLsLVGK
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95425 S238 Sugiyama SVIL HDLsPAAEsssTFsFSGRDssFtEVPRsPKHAHSssLQQAA
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P04040 S517 Sugiyama CAT LDKYNAEKPKNAIHtFVQsGsHLAAREKANL__________
P04040 T511 Sugiyama CAT SHIQALLDKYNAEKPKNAIHtFVQsGsHLAAREKANL____
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S356 Sugiyama ALDOA ALDA sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T246 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787 S410 Sugiyama KRT8 CYK8 TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 T55 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 VPsGAstGIyEALELRDNDKtRYMGKGVSKAVEHINKtIAP
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07355 S164 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGs
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P08238 S497 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09972 S356 Sugiyama ALDOC ALDC GLAAQGKYEGSGEDGGAAAQsLyIANHAY____________
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10809 S488 Sugiyama HSPD1 HSP60 IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14854 S52 Sugiyama COX6B1 COX6B QNyLDFHRCQKAMTAKGGDIsVCEWyQRVYQsLCPtsWVTD
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17987 S35 Sugiyama TCP1 CCT1 CCTA EtIRsQNVMAAAsIANIVKssLGPVGLDKMLVDDIGDVTIT
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22626 S225 Sugiyama HNRNPA2B1 HNRPA2B1 GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P23381 S358 Sugiyama WARS1 IFI53 WARS WRS TFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTKVNKHAFs
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P25786 T11 Sugiyama PSMA1 HC2 NU PROS30 PSC2 __________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692 S60 Sugiyama EEF1D EF1D ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P31327 S898 Sugiyama CPS1 LYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQIS
P31943 S269 Sugiyama HNRNPH1 HNRPH HNRPH1 YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQsttGH
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37108 S25 Sugiyama SRP14 EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P40855 S149 Sugiyama PEX19 HK33 PXF OK/SW-cl.22 LKETLSGLAKNATDLQNssMsEEELTKAMEGLGMDEGDGEG
P41091 T21 Sugiyama EIF2S3 EIF2G MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49588 S627 Sugiyama AARS1 AARS ATHILNFALRSVLGEADQKGsLVAPDRLRFDFTAKGAMSTQ
P50897 S262 Sugiyama PPT1 CLN1 PPT EWFGFYRsGQAKEtIPLQEtsLytQDRLGLKEMDNAGQLVF
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P52789 S889 Sugiyama HK2 PHFAKVMHETVKDLAPKCDVsFLQsEDGSGKGAALITAVAC
P52948 S683 Sugiyama NUP98 ADAR2 IAKPIPQtPEsAGNKHsNsNsVDDtIVALNMRAALRNGLEG
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P55060 S342 Sugiyama CSE1L CAS XPO2 ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF
P55795 S269 Sugiyama HNRNPH2 FTP3 HNRPH2 YNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQstTGH
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T90 Sugiyama TPI1 TPI VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T304 Sugiyama ACTB KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P61160 T237 EPSD|PSP ACTR2 ARP2 KEKLCYVGYNIEQEQKLALEttVLVESYTLPDGRIIKVGGE
P61160 T238 EPSD|PSP ACTR2 ARP2 EKLCYVGYNIEQEQKLALEttVLVESYTLPDGRIIKVGGER
P61353 T94 Sugiyama RPL27 VyNyNHLMPtRysVDIPLDKtVVNKDVFRDPALKRKARREA
P61604 S21 Sugiyama HSPE1 MAGQAFRKFLPLFDRVLVERsAAETVTKGGIMLPEKSQGKV
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62857 S41 Sugiyama RPS28 tGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtLLEs
P62937 S51 Sugiyama PPIA CYPA KtAENFRALSTGEKGFGYKGsCFHRIIPGFMCQGGDFtRHN
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T304 Sugiyama ACTG1 ACTG KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q06323 S55 Sugiyama PSME1 IFI5111 KKIsELDAFLKEPALNEANLsNLKAPLDIPVPDPVKEKEKE
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q13765 T119 Sugiyama NACA HSD48 SKNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAA
Q14247 S135 Sugiyama CTTN EMS1 VDsVRGFGGKFGVQMDRVDQsAVGFEyQGKtEKHAsQKDys
Q14247 S209 Sugiyama CTTN EMS1 RDYSKGFGGKyGIDKDKVDKsAVGFEyQGKtEKHESQKDyV
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15154 S372 EPSD|PSP PCM1 QLRDSQPPAVPDNRRQAESLsLTREVSQSRKPSASERLPDE
Q15185 S72 Sugiyama PTGES3 P23 TEBP EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15427 T14 Sugiyama SF3B4 SAP49 _______MAAGPISERNQDAtVyVGGLDEKVSEPLLWELFL
Q15468 S1116 EPSD|PSP STIL SIL LHINTDRSTVGLsLIsPNNMsFATKKYMKRYGLLQssDNsE
Q15468 S428 GPS6|PSP STIL SIL PsPHPVSQKISKIQPSVPELsLVLDGNFIESNPLPTPLEMV
Q2VIR3 T21 Sugiyama EIF2S3B MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF7 S370 Sugiyama HSP90AB3P HSP90BC KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z417 S655 Sugiyama NUFIP2 KIAA1321 PIG1 LGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsIWNL
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8NHV4 S325 GPS6|SIGNOR|PSP NEDD1 LTKSSLNKGCSNKPTTVNKRsVNVNAAsGGVQNsGIVREAP
Q8NHV4 S338 PSP NEDD1 PTTVNKRsVNVNAAsGGVQNsGIVREAPATSIATVLPQPMT
Q8NHV4 S404 PSP NEDD1 SKEtDsGKNQDFssFDDtGKssLGDMFsPIRDDAVVNKGsD
Q8NHV4 S568 PSP NEDD1 sstPNPKIAssVtAGVAssLsEKIADsIGNNRQNAPLTsIQ
Q8NHV4 T23 PSP NEDD1 ENLRFASSGDDIKIWDASSMtLVDKFNPHTSPHGISSICWS
Q8NHV4 T303 PSP NEDD1 PVKtISAHKTSVQCIAFQYStVLTKSSLNKGCSNKPTTVNK
Q8TDX7 S204 PSP NEK7 RFFssKttAAHsLVGtPyYMsPERIHENGYNFKSDIWSLGC
Q8WU90 T345 Sugiyama ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730 DsVsVNDIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDEN
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q969U6 S151 SIGNOR|EPSD|PSP FBXW5 FBW5 PP3971 ADMRPYNWSYTQFSQFNKDDsLLLASGVFLGPHNSSSGEIA
Q96D15 S76 Sugiyama RCN3 UNQ239/PRO272 HEAFLGREVAKEFDQLtPEEsQARLGRIVDRMDRAGDGDGW
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96RT7 S1060 SIGNOR TUBGCP6 GCP6 KIAA1669 ASEIAPTRPRWNTHGHVSDAsIRVGENVSDVAPTQPRWNTH
Q96RT7 S1087 SIGNOR TUBGCP6 GCP6 KIAA1669 VSDVAPTQPRWNTHGHVSNAsISLGESVSDVAPTRPRWNIH
Q96RT7 S1114 SIGNOR TUBGCP6 GCP6 KIAA1669 VSDVAPTRPRWNIHGHVSNAsIRVGENVSDVAPTRPRWNTH
Q96RT7 S1168 SIGNOR TUBGCP6 GCP6 KIAA1669 VSDVAPTRPRWNTHGHVSDAsISLGESVsDMAPARPRWNTH
Q96RT7 S1176 SIGNOR TUBGCP6 GCP6 KIAA1669 PRWNTHGHVSDAsISLGESVsDMAPARPRWNTHGHVSDAsI
Q96RT7 S1195 SIGNOR TUBGCP6 GCP6 KIAA1669 VsDMAPARPRWNTHGHVSDAsISLGESVSDMAPTRPRWNTH
Q96RT7 S1249 SIGNOR TUBGCP6 GCP6 KIAA1669 VSDVAPIRsRCNTHGHVSDAsISLGEPVSDVVSTRPRWNTH
Q96RT7 S1437 SIGNOR TUBGCP6 GCP6 KIAA1669 AYLAGLAGQYHLERYPDSYEsMSEPPIAHLLRPVLPRAFAF
Q96RT7 S1465 SIGNOR TUBGCP6 GCP6 KIAA1669 HLLRPVLPRAFAFPVDPQVQsAADETAVQLSELLTLPVLMK
Q96RT7 S392 SIGNOR TUBGCP6 GCP6 KIAA1669 QPAQAFVVKRGVHVSGASPEsISSLLSEVAEYGTCYTRLSH
Q96T49 S69 PSP PPP1R16B ANKRD4 KIAA0823 RKHERKRSTGGRRKKVSFEAsVALLEASLRNDAEEVRYFLK
Q99497 S57 Sugiyama PARK7 GLAGKDPVQCsRDVVICPDAsLEDAKKEGPyDVVVLPGGNL
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BZK7 S506 Sugiyama TBL1XR1 IRA1 TBLR1 IFEVCWNAAGDKVGASASDGsVCVLDLRK____________
Q9HC77 S595 GPS6|SIGNOR|EPSD|PSP CPAP CENPJ LAP LIP1 LDEFLFLEQAADEIsFSSNSsFVLKILERDQQICKGHRMSS
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9UPN4 S21 PSP CEP131 AZI1 KIAA1118 MKGTRAIGSVPERsPAGVDLsLTGLPPPVSRRPGsAATtKP
Q9UPN4 S78 PSP CEP131 AZI1 KIAA1118 VLEATGPGGSQAINNLRRsNsttQVSQPRsGsPRPtEPtDF
Q9UPN4 T205 PSP CEP131 AZI1 KIAA1118 MVHNRYTPSERAPPLKSSNQtAPsLNNIIKAATCEGsESsG
Q9Y2B0 S55 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDELEWEIAQVDPKKTIQMGsFRINPDGsQsVVEVPyARsE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.819966e-14 13.550 1 0
Signal Transduction R-HSA-162582 1.134315e-12 11.945 0 0
Mitotic Prometaphase R-HSA-68877 1.106437e-11 10.956 1 0
Cell Cycle Checkpoints R-HSA-69620 8.374268e-11 10.077 0 0
M Phase R-HSA-68886 2.223975e-10 9.653 1 0
Cell Cycle, Mitotic R-HSA-69278 7.254740e-10 9.139 1 0
Mitotic Anaphase R-HSA-68882 1.097736e-09 8.960 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.162602e-09 8.935 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.306407e-09 8.884 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.895929e-09 8.722 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.589216e-09 8.587 0 0
Separation of Sister Chromatids R-HSA-2467813 3.525589e-09 8.453 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.809705e-09 8.419 0 0
Apoptosis R-HSA-109581 5.795887e-09 8.237 0 0
Apoptotic execution phase R-HSA-75153 8.871540e-09 8.052 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.497155e-07 6.825 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.497155e-07 6.825 0 0
Programmed Cell Death R-HSA-5357801 2.140645e-07 6.669 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.943691e-07 6.404 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.098182e-07 6.387 0 0
Cellular response to heat stress R-HSA-3371556 5.445345e-07 6.264 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.198425e-07 6.208 0 0
Signaling by ERBB2 R-HSA-1227986 8.807404e-07 6.055 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.068154e-06 5.971 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.083079e-06 5.681 0 0
Signaling by VEGF R-HSA-194138 3.178955e-06 5.498 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.758881e-06 5.425 0 0
G2/M Checkpoints R-HSA-69481 4.479101e-06 5.349 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.044143e-06 5.219 0 0
Axon guidance R-HSA-422475 5.949843e-06 5.225 0 0
Platelet activation, signaling and aggregation R-HSA-76002 7.559486e-06 5.122 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.487868e-06 5.023 0 0
SARS-CoV-1-host interactions R-HSA-9692914 9.589716e-06 5.018 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.010948e-05 4.995 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.224402e-05 4.912 0 0
Regulation of TP53 Activity R-HSA-5633007 1.235768e-05 4.908 0 0
Selective autophagy R-HSA-9663891 1.417729e-05 4.848 0 0
Cellular responses to stimuli R-HSA-8953897 1.449747e-05 4.839 0 0
Aggrephagy R-HSA-9646399 1.910762e-05 4.719 0 0
Death Receptor Signaling R-HSA-73887 2.194726e-05 4.659 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.317285e-05 4.635 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.901842e-05 4.537 0 0
G2/M Transition R-HSA-69275 2.934946e-05 4.532 1 0
SARS-CoV-2-host interactions R-HSA-9705683 3.199534e-05 4.495 0 0
Glycolysis R-HSA-70171 3.390142e-05 4.470 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.587216e-05 4.445 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.757446e-05 4.425 1 0
Nervous system development R-HSA-9675108 3.869293e-05 4.412 0 0
Autophagy R-HSA-9612973 5.735482e-05 4.241 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 5.834629e-05 4.234 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.450702e-05 4.190 0 0
Cellular responses to stress R-HSA-2262752 6.482092e-05 4.188 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.597221e-05 4.119 1 1
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.616531e-05 4.118 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.885999e-05 4.103 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.574384e-05 4.067 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.038180e-04 3.984 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.038180e-04 3.984 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.013060e-04 3.994 0 0
Nuclear import of Rev protein R-HSA-180746 1.054681e-04 3.977 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.044150e-04 3.981 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.067804e-04 3.972 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.067804e-04 3.972 0 0
Diseases of DNA repair R-HSA-9675135 1.234333e-04 3.909 0 0
Membrane Trafficking R-HSA-199991 1.250479e-04 3.903 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.396465e-04 3.855 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.362754e-04 3.866 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.398785e-04 3.854 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.312315e-04 3.882 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.468210e-04 3.833 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.652068e-04 3.782 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.908580e-04 3.719 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.848596e-04 3.733 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.864047e-04 3.730 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.763650e-04 3.754 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.824660e-04 3.739 1 1
Interactions of Rev with host cellular proteins R-HSA-177243 1.763650e-04 3.754 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.763650e-04 3.754 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.956731e-04 3.708 0 0
Homology Directed Repair R-HSA-5693538 1.947905e-04 3.710 0 0
Rap1 signalling R-HSA-392517 2.031085e-04 3.692 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.958126e-04 3.708 0 0
PKR-mediated signaling R-HSA-9833482 2.004036e-04 3.698 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.044353e-04 3.689 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 2.074417e-04 3.683 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.384529e-04 3.623 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.429542e-04 3.614 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.458299e-04 3.609 0 0
Activation of BH3-only proteins R-HSA-114452 2.482025e-04 3.605 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.630618e-04 3.580 0 0
Signaling by ALK in cancer R-HSA-9700206 2.630618e-04 3.580 0 0
Signaling by PTK6 R-HSA-8848021 2.732544e-04 3.563 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.732544e-04 3.563 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.827749e-04 3.549 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.096764e-04 3.509 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.629991e-04 3.440 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.210043e-04 3.493 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.210043e-04 3.493 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.629991e-04 3.440 0 0
G alpha (12/13) signalling events R-HSA-416482 3.233863e-04 3.490 0 0
Glucose metabolism R-HSA-70326 3.418790e-04 3.466 0 0
Macroautophagy R-HSA-1632852 3.898357e-04 3.409 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.917859e-04 3.407 0 0
Recycling pathway of L1 R-HSA-437239 4.182812e-04 3.379 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.026777e-04 3.395 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.026777e-04 3.395 0 0
ESR-mediated signaling R-HSA-8939211 4.266437e-04 3.370 0 0
Cell-Cell communication R-HSA-1500931 4.033894e-04 3.394 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.526425e-04 3.344 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.526425e-04 3.344 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.787970e-04 3.320 1 1
Transcriptional Regulation by TP53 R-HSA-3700989 4.959948e-04 3.305 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.409190e-04 3.267 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.290458e-04 3.277 0 0
Ribosome-associated quality control R-HSA-9948299 5.121714e-04 3.291 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.392911e-04 3.268 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.023680e-04 3.299 0 0
Influenza Infection R-HSA-168255 5.126033e-04 3.290 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.953685e-04 3.225 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.291997e-04 3.201 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.348726e-04 3.197 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.429509e-04 3.192 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.518961e-04 3.186 1 1
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.518961e-04 3.186 1 1
Ovarian tumor domain proteases R-HSA-5689896 6.766410e-04 3.170 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.766410e-04 3.170 0 0
Nuclear Receptor transcription pathway R-HSA-383280 7.203455e-04 3.142 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.891575e-04 3.162 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.766410e-04 3.170 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.707163e-04 3.173 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.456884e-04 3.127 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.801969e-04 3.108 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.823892e-04 3.107 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.512323e-04 3.070 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.530766e-04 3.069 0 0
Signaling by RAS mutants R-HSA-6802949 8.707558e-04 3.060 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.707558e-04 3.060 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.707558e-04 3.060 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.707558e-04 3.060 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.707558e-04 3.060 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 9.264968e-04 3.033 0 0
NRAGE signals death through JNK R-HSA-193648 1.010470e-03 2.995 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.010470e-03 2.995 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.043108e-03 2.982 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.071517e-03 2.970 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.087759e-03 2.963 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.087759e-03 2.963 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.087759e-03 2.963 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.211051e-03 2.917 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.141608e-03 2.942 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.141608e-03 2.942 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.140892e-03 2.943 1 1
Regulation of CDH1 Function R-HSA-9764561 1.210919e-03 2.917 0 0
MAPK family signaling cascades R-HSA-5683057 1.112418e-03 2.954 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.165989e-03 2.933 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.211051e-03 2.917 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.118945e-03 2.951 0 0
L1CAM interactions R-HSA-373760 1.141608e-03 2.942 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.217761e-03 2.914 0 0
Interferon Signaling R-HSA-913531 1.220176e-03 2.914 0 0
Metabolism of RNA R-HSA-8953854 1.290927e-03 2.889 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.337023e-03 2.874 0 0
Signaling by Hippo R-HSA-2028269 1.352216e-03 2.869 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.389903e-03 2.857 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.389903e-03 2.857 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.401696e-03 2.853 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.401696e-03 2.853 0 0
RET signaling R-HSA-8853659 1.461407e-03 2.835 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.540887e-03 2.812 1 1
Host Interactions of HIV factors R-HSA-162909 1.571113e-03 2.804 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.752738e-03 2.756 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.752738e-03 2.756 0 0
Late endosomal microautophagy R-HSA-9615710 1.718342e-03 2.765 0 0
FLT3 Signaling R-HSA-9607240 1.633600e-03 2.787 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.633600e-03 2.787 0 0
p75NTR signals via NF-kB R-HSA-193639 1.752738e-03 2.756 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.595363e-03 2.797 0 0
Signaling by NTRKs R-HSA-166520 1.733549e-03 2.761 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.633600e-03 2.787 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.760137e-03 2.754 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.774607e-03 2.751 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.817567e-03 2.741 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.817567e-03 2.741 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.924165e-03 2.716 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.931889e-03 2.714 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.185406e-03 2.660 0 0
MAP2K and MAPK activation R-HSA-5674135 2.000256e-03 2.699 0 0
Centrosome maturation R-HSA-380287 2.083378e-03 2.681 1 0
Oncogenic MAPK signaling R-HSA-6802957 2.046798e-03 2.689 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.980226e-03 2.703 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.980226e-03 2.703 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.145872e-03 2.668 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.185713e-03 2.660 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.185713e-03 2.660 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.185713e-03 2.660 0 0
Kinesins R-HSA-983189 2.027761e-03 2.693 0 0
Interleukin-37 signaling R-HSA-9008059 2.185406e-03 2.660 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.231738e-03 2.651 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.421274e-03 2.616 0 0
Mitophagy R-HSA-5205647 2.495596e-03 2.603 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.522039e-03 2.598 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.651697e-03 2.576 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.651697e-03 2.576 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.651697e-03 2.576 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.651697e-03 2.576 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.651697e-03 2.576 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.651697e-03 2.576 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.651697e-03 2.576 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.651697e-03 2.576 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.651697e-03 2.576 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.651697e-03 2.576 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.651697e-03 2.576 0 0
Josephin domain DUBs R-HSA-5689877 2.759078e-03 2.559 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.997561e-03 2.523 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.752078e-03 2.560 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.983748e-03 2.525 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.806053e-03 2.552 0 0
Signalling to ERKs R-HSA-187687 3.082488e-03 2.511 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.730796e-03 2.564 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.881239e-03 2.540 0 0
tRNA processing in the nucleus R-HSA-6784531 2.798863e-03 2.553 0 0
Cell junction organization R-HSA-446728 2.937786e-03 2.532 0 0
Gene expression (Transcription) R-HSA-74160 2.842157e-03 2.546 0 0
Pexophagy R-HSA-9664873 2.759078e-03 2.559 0 0
Post NMDA receptor activation events R-HSA-438064 3.065196e-03 2.514 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.881239e-03 2.540 0 0
Signaling by ROBO receptors R-HSA-376176 2.871400e-03 2.542 0 0
Co-stimulation by CD28 R-HSA-389356 3.084901e-03 2.511 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.183254e-03 2.497 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.209711e-03 2.494 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.209711e-03 2.494 0 0
Interleukin-6 signaling R-HSA-1059683 3.212617e-03 2.493 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 3.212617e-03 2.493 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.242489e-03 2.489 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.354136e-03 2.474 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.354136e-03 2.474 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.354136e-03 2.474 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.354136e-03 2.474 0 0
Peptide chain elongation R-HSA-156902 3.488101e-03 2.457 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.534189e-03 2.452 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.582298e-03 2.446 0 0
Translation initiation complex formation R-HSA-72649 3.753722e-03 2.426 0 0
HSF1 activation R-HSA-3371511 3.777817e-03 2.423 0 0
snRNP Assembly R-HSA-191859 3.795710e-03 2.421 0 0
Metabolism of non-coding RNA R-HSA-194441 3.795710e-03 2.421 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.801974e-03 2.420 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.037481e-03 2.394 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.115703e-03 2.386 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.733212e-03 2.325 0 0
G-protein beta:gamma signalling R-HSA-397795 4.245726e-03 2.372 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.481009e-03 2.349 0 0
Deubiquitination R-HSA-5688426 4.681831e-03 2.330 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.184919e-03 2.378 0 0
G alpha (z) signalling events R-HSA-418597 4.406205e-03 2.356 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.733212e-03 2.325 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.117437e-03 2.385 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.499325e-03 2.347 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.481009e-03 2.349 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.245726e-03 2.372 0 0
HIV Life Cycle R-HSA-162587 4.147050e-03 2.382 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 4.499325e-03 2.347 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.221976e-03 2.374 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.062156e-03 2.296 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 5.099090e-03 2.293 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.099090e-03 2.293 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.109865e-03 2.292 0 0
MAP kinase activation R-HSA-450294 5.137946e-03 2.289 0 0
Signaling by EGFR R-HSA-177929 5.149247e-03 2.288 0 0
TNF signaling R-HSA-75893 5.149247e-03 2.288 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.206304e-03 2.283 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.473593e-03 2.262 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 5.664630e-03 2.247 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.664630e-03 2.247 0 0
G-protein mediated events R-HSA-112040 5.853232e-03 2.233 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.860709e-03 2.232 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.907043e-03 2.229 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.907043e-03 2.229 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.907043e-03 2.229 0 0
NF-kB is activated and signals survival R-HSA-209560 5.925298e-03 2.227 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.925298e-03 2.227 0 0
Mitotic Prophase R-HSA-68875 5.925351e-03 2.227 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.942621e-03 2.226 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.137214e-03 2.212 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.149135e-03 2.211 0 0
Dual Incision in GG-NER R-HSA-5696400 6.333532e-03 2.198 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.540329e-03 2.184 0 0
Inositol phosphate metabolism R-HSA-1483249 6.587703e-03 2.181 0 0
EGFR downregulation R-HSA-182971 7.191137e-03 2.143 0 0
GPER1 signaling R-HSA-9634597 6.966723e-03 2.157 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.936660e-03 2.159 0 0
Signaling by FGFR4 R-HSA-5654743 6.863853e-03 2.163 0 0
Translesion Synthesis by POLH R-HSA-110320 7.806590e-03 2.108 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.699836e-03 2.114 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.191137e-03 2.143 0 0
HIV Infection R-HSA-162906 7.977838e-03 2.098 0 0
Semaphorin interactions R-HSA-373755 6.847424e-03 2.164 0 0
Opioid Signalling R-HSA-111885 8.112942e-03 2.091 0 0
Prolonged ERK activation events R-HSA-169893 8.221736e-03 2.085 0 0
Negative regulation of FLT3 R-HSA-9706369 8.221736e-03 2.085 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.221736e-03 2.085 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 8.271311e-03 2.082 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.518073e-03 2.070 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.530951e-03 2.069 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 9.062340e-03 2.043 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.165774e-03 2.038 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.213415e-03 2.036 0 0
Signaling by FGFR3 R-HSA-5654741 9.501671e-03 2.022 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.833026e-03 2.007 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.958953e-03 2.002 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 9.987571e-03 2.001 0 0
Nephrin family interactions R-HSA-373753 9.987571e-03 2.001 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.998492e-03 2.000 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.053180e-02 1.977 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.055600e-02 1.977 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.055600e-02 1.977 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.080497e-02 1.966 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.091148e-02 1.962 0 0
Signal attenuation R-HSA-74749 1.101695e-02 1.958 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.101695e-02 1.958 0 0
Regulation of CDH11 function R-HSA-9762292 1.101695e-02 1.958 0 0
Frs2-mediated activation R-HSA-170968 1.123783e-02 1.949 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.125850e-02 1.949 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.125850e-02 1.949 0 0
Neurodegenerative Diseases R-HSA-8863678 1.125850e-02 1.949 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.125850e-02 1.949 0 0
Signaling by Interleukins R-HSA-449147 1.160143e-02 1.935 0 0
Interleukin-1 family signaling R-HSA-446652 1.180772e-02 1.928 0 0
Regulation of PTEN localization R-HSA-8948747 1.438314e-02 1.842 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.438314e-02 1.842 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.490728e-02 1.827 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.383540e-02 1.859 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.211499e-02 1.917 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.211499e-02 1.917 0 0
Striated Muscle Contraction R-HSA-390522 1.263973e-02 1.898 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.319144e-02 1.880 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.359623e-02 1.867 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.263973e-02 1.898 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 1.296996e-02 1.887 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.373189e-02 1.862 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.305754e-02 1.884 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.262383e-02 1.899 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.386243e-02 1.858 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.291637e-02 1.889 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.406677e-02 1.852 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.212244e-02 1.916 0 0
MTOR signalling R-HSA-165159 1.296996e-02 1.887 0 0
Signaling by TGFB family members R-HSA-9006936 1.401773e-02 1.853 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.296996e-02 1.887 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.446758e-02 1.840 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.387885e-02 1.858 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.267988e-02 1.897 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 1.290492e-02 1.889 0 0
Signal amplification R-HSA-392518 1.502448e-02 1.823 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.502448e-02 1.823 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.516747e-02 1.819 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.531287e-02 1.815 0 0
DNA Repair R-HSA-73894 1.539730e-02 1.813 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.561601e-02 1.806 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.561601e-02 1.806 0 0
Assembly Of The HIV Virion R-HSA-175474 1.568500e-02 1.805 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.596771e-02 1.797 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.611228e-02 1.793 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.632263e-02 1.787 0 0
RNA Polymerase II Transcription R-HSA-73857 1.657498e-02 1.781 0 0
Interleukin-17 signaling R-HSA-448424 1.675936e-02 1.776 0 0
DNA Damage Bypass R-HSA-73893 1.713287e-02 1.766 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.713287e-02 1.766 0 0
Gap junction trafficking and regulation R-HSA-157858 1.713287e-02 1.766 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.728351e-02 1.762 0 0
Gap junction trafficking R-HSA-190828 1.750094e-02 1.757 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.758369e-02 1.755 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.758369e-02 1.755 0 0
Eukaryotic Translation Termination R-HSA-72764 1.763009e-02 1.754 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.772061e-02 1.752 0 0
Attenuation phase R-HSA-3371568 1.772061e-02 1.752 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.788737e-02 1.747 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.791804e-02 1.747 0 0
IRE1alpha activates chaperones R-HSA-381070 1.869901e-02 1.728 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.935824e-02 1.713 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.947891e-02 1.710 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.947891e-02 1.710 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.952136e-02 1.709 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.981926e-02 1.703 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.007317e-02 1.697 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 2.017491e-02 1.695 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.022257e-02 1.694 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.022257e-02 1.694 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.027832e-02 1.693 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.027832e-02 1.693 0 0
EPH-Ephrin signaling R-HSA-2682334 2.063582e-02 1.685 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.064522e-02 1.685 0 0
Gene Silencing by RNA R-HSA-211000 2.064669e-02 1.685 0 0
Activation of RAC1 R-HSA-428540 2.064896e-02 1.685 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.064896e-02 1.685 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.064896e-02 1.685 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.070604e-02 1.684 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.079779e-02 1.682 0 0
Signaling by FGFR1 R-HSA-5654736 2.153789e-02 1.667 0 0
The NLRP3 inflammasome R-HSA-844456 2.194945e-02 1.659 0 0
MHC class II antigen presentation R-HSA-2132295 2.197594e-02 1.658 0 0
DNA Double Strand Break Response R-HSA-5693606 2.213866e-02 1.655 0 0
HSF1-dependent transactivation R-HSA-3371571 2.238224e-02 1.650 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.348232e-02 1.629 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.423585e-02 1.616 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.441834e-02 1.612 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.441834e-02 1.612 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.441834e-02 1.612 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.441834e-02 1.612 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.276046e-02 1.485 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.276046e-02 1.485 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.276046e-02 1.485 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.276046e-02 1.485 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.276046e-02 1.485 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.276046e-02 1.485 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.276046e-02 1.485 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.745883e-02 1.561 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.745883e-02 1.561 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.861110e-02 1.543 0 0
Gap junction degradation R-HSA-190873 2.861110e-02 1.543 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.861110e-02 1.543 0 0
ALK mutants bind TKIs R-HSA-9700645 2.861110e-02 1.543 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.712137e-02 1.567 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.712137e-02 1.567 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.702923e-02 1.568 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.702923e-02 1.568 0 0
ERK/MAPK targets R-HSA-198753 3.287128e-02 1.483 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.287128e-02 1.483 0 0
Deadenylation of mRNA R-HSA-429947 2.824760e-02 1.549 0 0
mRNA Splicing R-HSA-72172 2.799104e-02 1.553 0 0
Nucleotide Excision Repair R-HSA-5696398 2.866456e-02 1.543 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 3.287128e-02 1.483 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.275274e-02 1.485 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.728775e-02 1.564 0 0
Toll-like Receptor Cascades R-HSA-168898 2.493408e-02 1.603 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.867544e-02 1.542 0 0
Negative regulation of MET activity R-HSA-6807004 2.702923e-02 1.568 0 0
Signaling by SCF-KIT R-HSA-1433557 3.126027e-02 1.505 0 0
Glucagon-type ligand receptors R-HSA-420092 2.867544e-02 1.542 0 0
Muscle contraction R-HSA-397014 3.131964e-02 1.504 0 0
Generic Transcription Pathway R-HSA-212436 3.116042e-02 1.506 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.712137e-02 1.567 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.712137e-02 1.567 0 0
Smooth Muscle Contraction R-HSA-445355 2.875821e-02 1.541 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.864964e-02 1.543 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.872954e-02 1.542 0 0
Maturation of protein E R-HSA-9683683 2.745883e-02 1.561 0 0
Maturation of protein E R-HSA-9694493 2.745883e-02 1.561 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.318306e-02 1.479 0 0
RAF activation R-HSA-5673000 3.318306e-02 1.479 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.318306e-02 1.479 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.318306e-02 1.479 0 0
Degradation of CDH1 R-HSA-9766229 3.401576e-02 1.468 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.446630e-02 1.463 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.481041e-02 1.458 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.481041e-02 1.458 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 3.481041e-02 1.458 0 0
Protein folding R-HSA-391251 3.501361e-02 1.456 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.557728e-02 1.449 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.768654e-02 1.424 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.768654e-02 1.424 0 0
PTEN Regulation R-HSA-6807070 3.790405e-02 1.421 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.808663e-02 1.419 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.808663e-02 1.419 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.808663e-02 1.419 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.819967e-02 1.418 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.831159e-02 1.417 0 0
Budding and maturation of HIV virion R-HSA-162588 3.928438e-02 1.406 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.928438e-02 1.406 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.951075e-02 1.403 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.951075e-02 1.403 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.951804e-02 1.403 0 0
Hemostasis R-HSA-109582 3.975701e-02 1.401 0 0
Metalloprotease DUBs R-HSA-5689901 3.977675e-02 1.400 0 0
DAG and IP3 signaling R-HSA-1489509 4.030414e-02 1.395 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.036969e-02 1.394 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.220263e-02 1.375 0 0
TCR signaling R-HSA-202403 4.304476e-02 1.366 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.377854e-02 1.359 0 0
FLT3 signaling in disease R-HSA-9682385 4.396806e-02 1.357 0 0
GPVI-mediated activation cascade R-HSA-114604 4.396806e-02 1.357 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.545722e-02 1.342 0 0
Hedgehog 'off' state R-HSA-5610787 4.578780e-02 1.339 0 0
Platelet sensitization by LDL R-HSA-432142 4.630578e-02 1.334 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.630578e-02 1.334 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.658946e-02 1.332 0 0
Signaling by FGFR2 R-HSA-5654738 4.687612e-02 1.329 0 0
Notch-HLH transcription pathway R-HSA-350054 4.700533e-02 1.328 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.700533e-02 1.328 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.868625e-02 1.313 0 0
S Phase R-HSA-69242 4.933506e-02 1.307 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.953614e-02 1.305 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.953614e-02 1.305 0 0
Interleukin-2 signaling R-HSA-9020558 4.953614e-02 1.305 0 0
Selenocysteine synthesis R-HSA-2408557 4.956560e-02 1.305 0 0
Platelet degranulation R-HSA-114608 5.014791e-02 1.300 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.105143e-02 1.292 0 0
SARS-CoV Infections R-HSA-9679506 5.172210e-02 1.286 0 0
IGF1R signaling cascade R-HSA-2428924 5.224292e-02 1.282 0 0
Signaling by Hedgehog R-HSA-5358351 5.322737e-02 1.274 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.368624e-02 1.270 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.368624e-02 1.270 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.368624e-02 1.270 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.368624e-02 1.270 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.368624e-02 1.270 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.386123e-02 1.269 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.386123e-02 1.269 0 0
Ca-dependent events R-HSA-111996 5.399530e-02 1.268 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.406910e-02 1.267 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.406910e-02 1.267 0 0
Translesion synthesis by REV1 R-HSA-110312 5.406910e-02 1.267 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.406910e-02 1.267 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.413099e-02 1.267 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.413099e-02 1.267 0 0
IFNG signaling activates MAPKs R-HSA-9732724 5.413099e-02 1.267 0 0
PTK6 Expression R-HSA-8849473 5.413099e-02 1.267 0 0
Disinhibition of SNARE formation R-HSA-114516 5.413099e-02 1.267 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.413571e-02 1.267 0 0
Vesicle-mediated transport R-HSA-5653656 5.414926e-02 1.266 0 0
Signaling by WNT R-HSA-195721 5.434405e-02 1.265 0 0
UCH proteinases R-HSA-5689603 5.494129e-02 1.260 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.536168e-02 1.257 0 0
Growth hormone receptor signaling R-HSA-982772 5.536168e-02 1.257 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.557900e-02 1.255 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.677315e-02 1.246 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.694153e-02 1.245 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.709998e-02 1.243 0 0
Defective Base Excision Repair Associated with OGG1 R-HSA-9656249 6.731718e-02 1.172 0 0
Manipulation of host energy metabolism R-HSA-9636667 6.731718e-02 1.172 0 0
IKBKB deficiency causes SCID R-HSA-5602636 6.731718e-02 1.172 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 6.731718e-02 1.172 0 0
IRS activation R-HSA-74713 7.713593e-02 1.113 0 0
Regulation by c-FLIP R-HSA-3371378 7.128545e-02 1.147 0 0
Dimerization of procaspase-8 R-HSA-69416 7.128545e-02 1.147 0 0
Formation of annular gap junctions R-HSA-196025 7.128545e-02 1.147 0 0
ERKs are inactivated R-HSA-202670 6.264796e-02 1.203 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.264796e-02 1.203 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.752712e-02 1.111 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.752712e-02 1.111 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.752712e-02 1.111 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.752712e-02 1.111 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.752712e-02 1.111 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.752712e-02 1.111 0 0
Translesion synthesis by POLI R-HSA-5656121 6.570580e-02 1.182 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.869272e-02 1.104 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.869272e-02 1.104 0 0
Translesion synthesis by POLK R-HSA-5655862 7.869272e-02 1.104 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.592836e-02 1.181 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.243507e-02 1.205 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.243507e-02 1.205 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 6.243507e-02 1.205 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.980209e-02 1.223 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.222837e-02 1.141 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.222837e-02 1.141 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.807621e-02 1.107 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.275532e-02 1.138 0 0
mRNA 3'-end processing R-HSA-72187 8.603653e-02 1.065 0 0
Viral mRNA Translation R-HSA-192823 5.778496e-02 1.238 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.754602e-02 1.240 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.754218e-02 1.240 0 0
Interleukin-2 family signaling R-HSA-451927 7.222837e-02 1.141 0 0
Regulated Necrosis R-HSA-5218859 7.561818e-02 1.121 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 6.460790e-02 1.190 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.869272e-02 1.104 0 0
Interleukin-6 family signaling R-HSA-6783589 6.460790e-02 1.190 0 0
Signaling by NOTCH3 R-HSA-9012852 6.596303e-02 1.181 0 0
Interleukin-9 signaling R-HSA-8985947 7.128545e-02 1.147 0 0
VLDLR internalisation and degradation R-HSA-8866427 7.752712e-02 1.111 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.752712e-02 1.111 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.570580e-02 1.182 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.596303e-02 1.181 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.046770e-02 1.094 0 0
Signaling by LTK R-HSA-9842663 7.752712e-02 1.111 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.731718e-02 1.172 0 0
Ca2+ pathway R-HSA-4086398 7.028944e-02 1.153 0 0
Cilium Assembly R-HSA-5617833 6.918294e-02 1.160 1 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 7.869272e-02 1.104 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.475672e-02 1.126 0 0
Adherens junctions interactions R-HSA-418990 6.100555e-02 1.215 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 7.713593e-02 1.113 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.264796e-02 1.203 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.869272e-02 1.104 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.326805e-02 1.080 0 0
Cell-cell junction organization R-HSA-421270 6.511659e-02 1.186 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.475672e-02 1.126 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.128545e-02 1.147 0 0
PLC beta mediated events R-HSA-112043 6.780398e-02 1.169 0 0
Chromatin organization R-HSA-4839726 5.925720e-02 1.227 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.128545e-02 1.147 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.736380e-02 1.111 0 0
Calmodulin induced events R-HSA-111933 8.625684e-02 1.064 0 0
CaM pathway R-HSA-111997 8.625684e-02 1.064 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.450602e-02 1.073 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.869272e-02 1.104 0 0
Insulin receptor signalling cascade R-HSA-74751 8.880787e-02 1.052 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.954358e-02 1.048 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.954358e-02 1.048 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 8.954358e-02 1.048 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.990360e-02 1.046 0 0
Signaling by FGFR1 in disease R-HSA-5655302 8.990360e-02 1.046 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.990360e-02 1.046 0 0
Interleukin-12 family signaling R-HSA-447115 9.000116e-02 1.046 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 9.087176e-02 1.042 0 0
ARMS-mediated activation R-HSA-170984 9.087176e-02 1.042 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 9.087176e-02 1.042 0 0
MAPK1 (ERK2) activation R-HSA-112411 9.087176e-02 1.042 0 0
CASP8 activity is inhibited R-HSA-5218900 9.087176e-02 1.042 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 9.087176e-02 1.042 0 0
CD28 dependent Vav1 pathway R-HSA-389359 9.413278e-02 1.026 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 9.413278e-02 1.026 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 9.413278e-02 1.026 0 0
Chromatin modifying enzymes R-HSA-3247509 9.590007e-02 1.018 0 0
Activation of GABAB receptors R-HSA-991365 9.964561e-02 1.002 0 0
GABA B receptor activation R-HSA-977444 9.964561e-02 1.002 0 0
Cellular response to chemical stress R-HSA-9711123 1.028476e-01 0.988 0 0
Integrin signaling R-HSA-354192 1.033552e-01 0.986 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.033552e-01 0.986 0 0
mTORC1-mediated signalling R-HSA-166208 1.034725e-01 0.985 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.034725e-01 0.985 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.038458e-01 0.984 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.042693e-01 0.982 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.042693e-01 0.982 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.043800e-01 0.981 0 0
Polo-like kinase mediated events R-HSA-156711 1.086399e-01 0.964 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.086399e-01 0.964 0 0
Ephrin signaling R-HSA-3928664 1.086399e-01 0.964 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.086399e-01 0.964 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.086399e-01 0.964 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.086399e-01 0.964 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.092103e-01 0.962 0 0
Potassium transport channels R-HSA-1296067 1.094196e-01 0.961 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 1.094196e-01 0.961 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 1.094196e-01 0.961 0 0
Developmental Biology R-HSA-1266738 1.098492e-01 0.959 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.099883e-01 0.959 0 0
Inflammasomes R-HSA-622312 1.106233e-01 0.956 0 0
Meiosis R-HSA-1500620 1.121130e-01 0.950 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.123947e-01 0.949 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.123947e-01 0.949 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.127319e-01 0.948 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 1.127319e-01 0.948 0 0
Interleukin-27 signaling R-HSA-9020956 1.127319e-01 0.948 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.134094e-01 0.945 0 0
Interleukin-1 signaling R-HSA-9020702 1.162485e-01 0.935 0 0
Signaling by ALK R-HSA-201556 1.188013e-01 0.925 0 0
Signaling by NOTCH4 R-HSA-9013694 1.219948e-01 0.914 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.221839e-01 0.913 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.228853e-01 0.911 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.236871e-01 0.908 0 0
PI Metabolism R-HSA-1483255 1.236871e-01 0.908 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.239128e-01 0.907 0 0
Regulation of signaling by CBL R-HSA-912631 1.255182e-01 0.901 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.255182e-01 0.901 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 1.255182e-01 0.901 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.284189e-01 0.891 0 0
Gap junction assembly R-HSA-190861 1.284189e-01 0.891 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.298158e-01 0.887 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.309777e-01 0.883 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.310007e-01 0.883 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.310007e-01 0.883 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.310007e-01 0.883 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.310007e-01 0.883 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.310007e-01 0.883 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.310007e-01 0.883 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.310007e-01 0.883 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.310007e-01 0.883 0 0
Defective OGG1 Localization R-HSA-9657050 1.310007e-01 0.883 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.310007e-01 0.883 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.310007e-01 0.883 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.310007e-01 0.883 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.310007e-01 0.883 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.310007e-01 0.883 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.310007e-01 0.883 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.310007e-01 0.883 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.310007e-01 0.883 0 0
Defective OGG1 Substrate Binding R-HSA-9656255 1.310007e-01 0.883 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.310007e-01 0.883 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.310629e-01 0.883 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.310629e-01 0.883 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.320680e-01 0.879 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 1.322171e-01 0.879 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.322171e-01 0.879 0 0
p38MAPK events R-HSA-171007 1.322171e-01 0.879 0 0
Protein methylation R-HSA-8876725 1.322171e-01 0.879 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.324482e-01 0.878 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.324482e-01 0.878 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.324482e-01 0.878 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.331181e-01 0.876 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.331882e-01 0.876 0 0
Signaling by LTK in cancer R-HSA-9842640 1.345598e-01 0.871 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 1.345598e-01 0.871 0 0
Nef and signal transduction R-HSA-164944 1.345598e-01 0.871 0 0
PECAM1 interactions R-HSA-210990 1.366648e-01 0.864 0 0
Signaling by APC mutants R-HSA-4839744 1.366648e-01 0.864 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.366648e-01 0.864 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.366648e-01 0.864 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.366648e-01 0.864 0 0
Suppression of apoptosis R-HSA-9635465 1.366648e-01 0.864 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.366648e-01 0.864 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 1.389157e-01 0.857 0 0
Integration of energy metabolism R-HSA-163685 1.392433e-01 0.856 0 0
Signaling by NOTCH1 R-HSA-1980143 1.405066e-01 0.852 0 0
Interleukin-12 signaling R-HSA-9020591 1.405066e-01 0.852 0 0
Signaling by FGFR R-HSA-190236 1.416871e-01 0.849 0 0
Signal transduction by L1 R-HSA-445144 1.435859e-01 0.843 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.437949e-01 0.842 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.437949e-01 0.842 0 0
Dual incision in TC-NER R-HSA-6782135 1.440628e-01 0.841 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.484781e-01 0.828 0 0
FOXO-mediated transcription R-HSA-9614085 1.502839e-01 0.823 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.534831e-01 0.814 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.539350e-01 0.813 0 0
Downstream signal transduction R-HSA-186763 1.542963e-01 0.812 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.542963e-01 0.812 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.542963e-01 0.812 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.448468e-01 0.611 0 0
Defective OGG1 Substrate Processing R-HSA-9656256 2.448468e-01 0.611 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.448468e-01 0.611 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.448468e-01 0.611 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.448468e-01 0.611 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 2.448468e-01 0.611 0 0
Defective MOGS causes CDG-2b R-HSA-4793954 2.448468e-01 0.611 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.448468e-01 0.611 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.448468e-01 0.611 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.448468e-01 0.611 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.448468e-01 0.611 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.448468e-01 0.611 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.448468e-01 0.611 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.448468e-01 0.611 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.564994e-01 0.805 0 0
Axonal growth stimulation R-HSA-209563 1.564994e-01 0.805 0 0
Invadopodia formation R-HSA-8941237 1.564994e-01 0.805 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 1.564994e-01 0.805 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.065313e-01 0.685 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.065313e-01 0.685 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.065313e-01 0.685 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.065313e-01 0.685 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.674458e-01 0.776 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.674458e-01 0.776 0 0
SOS-mediated signalling R-HSA-112412 1.674458e-01 0.776 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 1.674458e-01 0.776 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.674458e-01 0.776 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.579347e-01 0.588 0 0
Activation of AKT2 R-HSA-165158 2.579347e-01 0.588 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 2.579347e-01 0.588 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 2.579347e-01 0.588 0 0
Type I hemidesmosome assembly R-HSA-446107 2.023627e-01 0.694 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.023627e-01 0.694 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.023627e-01 0.694 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.897997e-01 0.722 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.387661e-01 0.622 0 0
Interleukin-21 signaling R-HSA-9020958 2.387661e-01 0.622 0 0
TRAIL signaling R-HSA-75158 3.094924e-01 0.509 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.094924e-01 0.509 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.094924e-01 0.509 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.094924e-01 0.509 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 3.094924e-01 0.509 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.094924e-01 0.509 0 0
Signaling by MAPK mutants R-HSA-9652817 3.094924e-01 0.509 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.094924e-01 0.509 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.760588e-01 0.754 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.627662e-01 0.788 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.627662e-01 0.788 0 0
PI3K/AKT activation R-HSA-198203 2.761472e-01 0.559 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.761472e-01 0.559 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.997973e-01 0.699 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.997973e-01 0.699 0 0
PKA activation in glucagon signalling R-HSA-164378 2.245432e-01 0.649 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.862349e-01 0.730 0 0
Erythropoietin activates RAS R-HSA-9027284 2.787709e-01 0.555 0 0
G beta:gamma signalling through BTK R-HSA-8964315 2.787709e-01 0.555 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.563917e-01 0.806 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.260646e-01 0.646 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.048810e-01 0.688 0 0
Meiotic synapsis R-HSA-1221632 1.565268e-01 0.805 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.565268e-01 0.805 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.457029e-01 0.610 0 0
G protein gated Potassium channels R-HSA-1296059 2.720240e-01 0.565 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 2.720240e-01 0.565 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 2.720240e-01 0.565 0 0
G-protein activation R-HSA-202040 3.032137e-01 0.518 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.200974e-01 0.657 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.952619e-01 0.709 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.610304e-01 0.583 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.327826e-01 0.633 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.327826e-01 0.633 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.280414e-01 0.642 0 0
Orc1 removal from chromatin R-HSA-68949 2.280414e-01 0.642 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.280414e-01 0.642 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 2.493324e-01 0.603 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.807064e-01 0.552 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.435412e-01 0.613 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.435412e-01 0.613 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.756209e-01 0.560 0 0
Neutrophil degranulation R-HSA-6798695 2.488615e-01 0.604 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 2.048810e-01 0.688 0 0
Ub-specific processing proteases R-HSA-5689880 1.872943e-01 0.727 0 0
Interleukin-15 signaling R-HSA-8983432 1.897997e-01 0.722 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.245432e-01 0.649 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.166642e-01 0.664 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.032137e-01 0.518 0 0
Chromosome Maintenance R-HSA-73886 2.703272e-01 0.568 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.761472e-01 0.559 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.041054e-01 0.690 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.794089e-01 0.746 0 0
Downstream TCR signaling R-HSA-202424 1.651123e-01 0.782 0 0
Signalling to RAS R-HSA-167044 1.627662e-01 0.788 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.627662e-01 0.788 0 0
IRS-mediated signalling R-HSA-112399 3.089077e-01 0.510 0 0
Adipogenesis R-HSA-9843745 2.564716e-01 0.591 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.579347e-01 0.588 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 2.720240e-01 0.565 0 0
Myogenesis R-HSA-525793 1.678716e-01 0.775 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.862349e-01 0.730 0 0
TRP channels R-HSA-3295583 2.958010e-01 0.529 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.761472e-01 0.559 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 1.678716e-01 0.775 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.787709e-01 0.555 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.417924e-01 0.617 0 0
PI3K Cascade R-HSA-109704 3.011628e-01 0.521 0 0
NGF-stimulated transcription R-HSA-9031628 2.662735e-01 0.575 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.829715e-01 0.738 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.482302e-01 0.605 0 0
Regulation of Apoptosis R-HSA-169911 2.417924e-01 0.617 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.378555e-01 0.624 0 0
Rab regulation of trafficking R-HSA-9007101 3.007848e-01 0.522 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 1.674458e-01 0.776 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.065313e-01 0.685 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 2.065313e-01 0.685 0 0
Transmission across Electrical Synapses R-HSA-112307 2.065313e-01 0.685 0 0
p75NTR regulates axonogenesis R-HSA-193697 2.387661e-01 0.622 0 0
MAPK3 (ERK1) activation R-HSA-110056 2.761472e-01 0.559 0 0
cGMP effects R-HSA-418457 2.482302e-01 0.605 0 0
ER-Phagosome pathway R-HSA-1236974 2.231088e-01 0.651 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.176541e-01 0.662 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.873271e-01 0.727 0 0
Long-term potentiation R-HSA-9620244 2.720240e-01 0.565 0 0
Inwardly rectifying K+ channels R-HSA-1296065 2.882166e-01 0.540 0 0
Degradation of DVL R-HSA-4641258 2.807064e-01 0.552 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 2.919291e-01 0.535 0 0
Regulation of insulin secretion R-HSA-422356 2.019881e-01 0.695 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.829715e-01 0.738 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.539613e-01 0.595 0 0
Interleukin-35 Signalling R-HSA-8984722 1.897997e-01 0.722 0 0
Interleukin-7 signaling R-HSA-1266695 2.720240e-01 0.565 0 0
Signaling by WNT in cancer R-HSA-4791275 2.882166e-01 0.540 0 0
Sensory perception of sour taste R-HSA-9729555 2.065313e-01 0.685 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.579347e-01 0.588 0 0
Adrenoceptors R-HSA-390696 2.023627e-01 0.694 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 2.023627e-01 0.694 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 2.387661e-01 0.622 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.184857e-01 0.661 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.761472e-01 0.559 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 1.997973e-01 0.699 0 0
HDL assembly R-HSA-8963896 2.482302e-01 0.605 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.671867e-01 0.777 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.671867e-01 0.777 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.671867e-01 0.777 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.671867e-01 0.777 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.549894e-01 0.810 0 0
Adaptive Immune System R-HSA-1280218 2.296831e-01 0.639 0 0
Signaling by BMP R-HSA-201451 1.862349e-01 0.730 0 0
Cellular response to starvation R-HSA-9711097 1.655453e-01 0.781 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.508628e-01 0.601 0 0
Signaling by MET R-HSA-6806834 2.606617e-01 0.584 0 0
Regulation of KIT signaling R-HSA-1433559 2.482302e-01 0.605 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.919291e-01 0.535 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.464181e-01 0.608 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 2.065313e-01 0.685 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.572329e-01 0.803 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.572329e-01 0.803 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 2.166642e-01 0.664 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.129457e-01 0.672 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.873271e-01 0.727 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.836211e-01 0.547 0 0
Cellular Senescence R-HSA-2559583 1.904621e-01 0.720 0 0
Platelet homeostasis R-HSA-418346 1.650242e-01 0.782 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.376722e-01 0.624 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.392847e-01 0.621 1 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.448468e-01 0.611 0 0
SDK interactions R-HSA-373756 2.448468e-01 0.611 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.564994e-01 0.805 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.564994e-01 0.805 0 0
RSK activation R-HSA-444257 2.023627e-01 0.694 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.624382e-01 0.789 0 0
Signaling by AXIN mutants R-HSA-4839735 1.624382e-01 0.789 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.094924e-01 0.509 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.094924e-01 0.509 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.761472e-01 0.559 0 0
DCC mediated attractive signaling R-HSA-418885 2.787709e-01 0.555 0 0
TBC/RABGAPs R-HSA-8854214 1.858721e-01 0.731 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.794089e-01 0.746 0 0
PCP/CE pathway R-HSA-4086400 1.604968e-01 0.795 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.978534e-01 0.526 0 0
Leishmania infection R-HSA-9658195 3.011135e-01 0.521 0 0
Parasitic Infection Pathways R-HSA-9824443 3.011135e-01 0.521 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.671867e-01 0.777 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.032952e-01 0.692 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.374106e-01 0.624 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.862349e-01 0.730 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.829715e-01 0.738 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.604968e-01 0.795 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.674458e-01 0.776 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.674458e-01 0.776 0 0
Interleukin-1 processing R-HSA-448706 2.387661e-01 0.622 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.674458e-01 0.776 0 0
Signaling by Leptin R-HSA-2586552 2.761472e-01 0.559 0 0
Oncogene Induced Senescence R-HSA-2559585 2.417924e-01 0.617 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.761472e-01 0.559 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.041054e-01 0.690 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.873271e-01 0.727 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.829715e-01 0.738 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.897997e-01 0.722 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.897997e-01 0.722 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.689732e-01 0.772 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.628822e-01 0.788 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.761472e-01 0.559 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.138152e-01 0.670 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.032137e-01 0.518 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.862349e-01 0.730 0 0
Diseases of Base Excision Repair R-HSA-9605308 3.094924e-01 0.509 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 2.387661e-01 0.622 0 0
Apoptotic factor-mediated response R-HSA-111471 2.245432e-01 0.649 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.787709e-01 0.555 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.094924e-01 0.509 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.952619e-01 0.709 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 3.098547e-01 0.509 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.098547e-01 0.509 0 0
Phosphorylation of the APC/C R-HSA-176412 3.098547e-01 0.509 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.098547e-01 0.509 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 3.098547e-01 0.509 0 0
Differentiation of T cells R-HSA-9945266 3.098547e-01 0.509 0 0
Regulation of BACH1 activity R-HSA-9708530 3.098547e-01 0.509 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.100876e-01 0.509 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.100876e-01 0.509 0 0
RMTs methylate histone arginines R-HSA-3214858 3.107913e-01 0.508 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.112967e-01 0.507 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 3.140420e-01 0.503 0 0
Bicarbonate transporters R-HSA-425381 3.140420e-01 0.503 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.140420e-01 0.503 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.211137e-01 0.493 0 0
RAS processing R-HSA-9648002 3.211137e-01 0.493 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.211137e-01 0.493 0 0
Stabilization of p53 R-HSA-69541 3.211137e-01 0.493 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.211960e-01 0.493 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.211960e-01 0.493 0 0
Hedgehog 'on' state R-HSA-5632684 3.211960e-01 0.493 0 0
G1/S Transition R-HSA-69206 3.270895e-01 0.485 0 0
HCMV Early Events R-HSA-9609690 3.270975e-01 0.485 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.278436e-01 0.484 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 3.299108e-01 0.482 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.299108e-01 0.482 0 0
Nucleosome assembly R-HSA-774815 3.299108e-01 0.482 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.299108e-01 0.482 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.303798e-01 0.481 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.303798e-01 0.481 0 0
Cellular response to hypoxia R-HSA-1234174 3.317653e-01 0.479 0 0
Effects of PIP2 hydrolysis R-HSA-114508 3.322569e-01 0.479 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.322569e-01 0.479 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.337894e-01 0.477 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.412423e-01 0.467 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.412423e-01 0.467 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.412423e-01 0.467 0 0
Disorders of Developmental Biology R-HSA-9675151 3.412423e-01 0.467 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.412423e-01 0.467 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.412423e-01 0.467 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.417145e-01 0.466 0 0
Diseases of Immune System R-HSA-5260271 3.417145e-01 0.466 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.437839e-01 0.464 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.437839e-01 0.464 0 0
Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 R-HSA-9916720 3.437839e-01 0.464 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.437839e-01 0.464 0 0
Intestinal infectious diseases R-HSA-8942233 3.437839e-01 0.464 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.437839e-01 0.464 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.437839e-01 0.464 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 3.437839e-01 0.464 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.437839e-01 0.464 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.437839e-01 0.464 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.437839e-01 0.464 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.437839e-01 0.464 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.437839e-01 0.464 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.437839e-01 0.464 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 3.437839e-01 0.464 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.437839e-01 0.464 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.520367e-01 0.453 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.520367e-01 0.453 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 3.520367e-01 0.453 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.520367e-01 0.453 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.520367e-01 0.453 0 0
Integration of provirus R-HSA-162592 3.520367e-01 0.453 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 3.520367e-01 0.453 0 0
Signaling by NOTCH2 R-HSA-1980145 3.546420e-01 0.450 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.546420e-01 0.450 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.546420e-01 0.450 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.577599e-01 0.446 0 0
Signaling by KIT in disease R-HSA-9669938 3.577599e-01 0.446 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.577599e-01 0.446 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.602821e-01 0.443 0 0
STAT5 Activation R-HSA-9645135 3.602821e-01 0.443 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.602821e-01 0.443 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.602821e-01 0.443 0 0
GABA receptor activation R-HSA-977443 3.604617e-01 0.443 0 0
Signaling by NOTCH R-HSA-157118 3.607285e-01 0.443 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.624938e-01 0.441 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.624938e-01 0.441 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.671684e-01 0.435 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.684406e-01 0.434 0 0
Signaling by Erythropoietin R-HSA-9006335 3.689894e-01 0.433 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.689894e-01 0.433 0 0
DARPP-32 events R-HSA-180024 3.689894e-01 0.433 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.727105e-01 0.429 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.727105e-01 0.429 0 0
Glycogen storage diseases R-HSA-3229121 3.727105e-01 0.429 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 3.737565e-01 0.427 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.771623e-01 0.423 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.771623e-01 0.423 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.771623e-01 0.423 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.814369e-01 0.419 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.833880e-01 0.416 0 0
Translation of Structural Proteins R-HSA-9683701 3.833880e-01 0.416 0 0
Syndecan interactions R-HSA-3000170 3.852098e-01 0.414 0 0
Intraflagellar transport R-HSA-5620924 3.882870e-01 0.411 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.897696e-01 0.409 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.897696e-01 0.409 0 0
Polymerase switching R-HSA-69091 3.897696e-01 0.409 0 0
Regulation of IFNG signaling R-HSA-877312 3.897696e-01 0.409 0 0
Leading Strand Synthesis R-HSA-69109 3.897696e-01 0.409 0 0
Repression of WNT target genes R-HSA-4641265 3.897696e-01 0.409 0 0
Pervasive developmental disorders R-HSA-9005895 3.897696e-01 0.409 0 0
Disorders of Nervous System Development R-HSA-9697154 3.897696e-01 0.409 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.897696e-01 0.409 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.936489e-01 0.405 0 0
DAP12 signaling R-HSA-2424491 3.936489e-01 0.405 0 0
Activation of the pre-replicative complex R-HSA-68962 3.936489e-01 0.405 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 3.946471e-01 0.404 0 0
GAB1 signalosome R-HSA-180292 4.040549e-01 0.394 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.040549e-01 0.394 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.040549e-01 0.394 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.040549e-01 0.394 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.040549e-01 0.394 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 4.040549e-01 0.394 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.040549e-01 0.394 0 0
Synthesis of DNA R-HSA-69239 4.078413e-01 0.390 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.096204e-01 0.388 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.096204e-01 0.388 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 4.096204e-01 0.388 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.096204e-01 0.388 0 0
Thromboxane signalling through TP receptor R-HSA-428930 4.125940e-01 0.384 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.125940e-01 0.384 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.130746e-01 0.384 0 0
Selenoamino acid metabolism R-HSA-2408522 4.131883e-01 0.384 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.139213e-01 0.383 0 0
Trafficking of AMPA receptors R-HSA-399719 4.182730e-01 0.379 0 0
Viral Infection Pathways R-HSA-9824446 4.206945e-01 0.376 0 0
Stimuli-sensing channels R-HSA-2672351 4.213898e-01 0.375 0 0
Degradation of AXIN R-HSA-4641257 4.222990e-01 0.374 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.243400e-01 0.372 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 4.269306e-01 0.370 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.269306e-01 0.370 0 0
Formation of axial mesoderm R-HSA-9796292 4.269306e-01 0.370 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 4.269306e-01 0.370 0 0
Maturation of nucleoprotein R-HSA-9683610 4.269306e-01 0.370 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.297636e-01 0.367 0 0
Signalling to ERK5 R-HSA-198765 4.297636e-01 0.367 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.297636e-01 0.367 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 4.297636e-01 0.367 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 4.297636e-01 0.367 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.297636e-01 0.367 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.297636e-01 0.367 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 4.297636e-01 0.367 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.297636e-01 0.367 0 0
Signaling by RAS GAP mutants R-HSA-9753510 4.297636e-01 0.367 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.297636e-01 0.367 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.297636e-01 0.367 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.297636e-01 0.367 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.297636e-01 0.367 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.297636e-01 0.367 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.297636e-01 0.367 0 0
C6 deamination of adenosine R-HSA-75102 4.297636e-01 0.367 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 4.297636e-01 0.367 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.297636e-01 0.367 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.297636e-01 0.367 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.297636e-01 0.367 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.317750e-01 0.365 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.317750e-01 0.365 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.339073e-01 0.363 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.350912e-01 0.361 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.351518e-01 0.361 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.397873e-01 0.357 0 0
Acyl chain remodelling of PS R-HSA-1482801 4.397873e-01 0.357 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 4.397873e-01 0.357 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.447686e-01 0.352 0 0
Netrin-1 signaling R-HSA-373752 4.461503e-01 0.351 0 0
SLC transporter disorders R-HSA-5619102 4.461809e-01 0.350 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.477926e-01 0.349 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.477926e-01 0.349 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.486703e-01 0.348 0 0
Sensory processing of sound R-HSA-9659379 4.487374e-01 0.348 0 0
HCMV Infection R-HSA-9609646 4.511589e-01 0.346 0 0
phospho-PLA2 pathway R-HSA-111995 4.570161e-01 0.340 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.570161e-01 0.340 0 0
Sodium/Proton exchangers R-HSA-425986 4.570161e-01 0.340 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.570161e-01 0.340 0 0
Interleukin-23 signaling R-HSA-9020933 4.570161e-01 0.340 0 0
Co-stimulation by ICOS R-HSA-9927354 4.570161e-01 0.340 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.609769e-01 0.336 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.632597e-01 0.334 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.632597e-01 0.334 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.632597e-01 0.334 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.632597e-01 0.334 0 0
Signal regulatory protein family interactions R-HSA-391160 4.632597e-01 0.334 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.632597e-01 0.334 0 0
Signaling by Insulin receptor R-HSA-74752 4.637241e-01 0.334 0 0
Signaling by NODAL R-HSA-1181150 4.656555e-01 0.332 0 0
Glycogen synthesis R-HSA-3322077 4.656555e-01 0.332 0 0
Extension of Telomeres R-HSA-180786 4.662160e-01 0.331 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.666748e-01 0.331 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.666748e-01 0.331 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.666748e-01 0.331 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 4.666748e-01 0.331 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.670514e-01 0.331 0 0
Plasma lipoprotein clearance R-HSA-8964043 4.670811e-01 0.331 0 0
Translation R-HSA-72766 4.759173e-01 0.322 0 0
rRNA processing R-HSA-72312 4.811561e-01 0.318 0 0
Signaling by ERBB4 R-HSA-1236394 4.819508e-01 0.317 0 0
Signaling by FGFR in disease R-HSA-1226099 4.819508e-01 0.317 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.874906e-01 0.312 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.874906e-01 0.312 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.931527e-01 0.307 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.931527e-01 0.307 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.931527e-01 0.307 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.931527e-01 0.307 0 0
Diseases of programmed cell death R-HSA-9645723 4.949548e-01 0.305 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.956044e-01 0.305 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.956044e-01 0.305 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 4.956044e-01 0.305 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.966646e-01 0.304 0 0
Protein ubiquitination R-HSA-8852135 4.985059e-01 0.302 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.985434e-01 0.302 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.985434e-01 0.302 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.985434e-01 0.302 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 4.985434e-01 0.302 0 0
Signaling by Activin R-HSA-1502540 4.985434e-01 0.302 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 4.985434e-01 0.302 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 4.985434e-01 0.302 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.005045e-01 0.301 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 5.021313e-01 0.299 0 0
Calcineurin activates NFAT R-HSA-2025928 5.021313e-01 0.299 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 5.021313e-01 0.299 0 0
Unwinding of DNA R-HSA-176974 5.021313e-01 0.299 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.021313e-01 0.299 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.021313e-01 0.299 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.021313e-01 0.299 0 0
Aquaporin-mediated transport R-HSA-445717 5.026947e-01 0.299 0 0
MET activates STAT3 R-HSA-8875791 5.044823e-01 0.297 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 5.044823e-01 0.297 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 5.044823e-01 0.297 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.044823e-01 0.297 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.044823e-01 0.297 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.044823e-01 0.297 0 0
Classical Kir channels R-HSA-1296053 5.044823e-01 0.297 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.044823e-01 0.297 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.044823e-01 0.297 0 0
Defective CYP1B1 causes Glaucoma R-HSA-5579000 5.044823e-01 0.297 0 0
Defective ABCA1 causes TGD R-HSA-5682113 5.044823e-01 0.297 0 0
MET activates PTPN11 R-HSA-8865999 5.044823e-01 0.297 0 0
Signalling to STAT3 R-HSA-198745 5.044823e-01 0.297 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 5.044823e-01 0.297 0 0
MET interacts with TNS proteins R-HSA-8875513 5.044823e-01 0.297 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.044823e-01 0.297 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.044823e-01 0.297 0 0
Histamine receptors R-HSA-390650 5.044823e-01 0.297 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.044823e-01 0.297 0 0
FasL/ CD95L signaling R-HSA-75157 5.044823e-01 0.297 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.078551e-01 0.294 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.109862e-01 0.292 0 0
Neddylation R-HSA-8951664 5.121943e-01 0.291 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.146634e-01 0.288 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.191283e-01 0.285 0 0
Telomere Extension By Telomerase R-HSA-171319 5.191283e-01 0.285 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.191283e-01 0.285 0 0
Pyroptosis R-HSA-5620971 5.191283e-01 0.285 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.206811e-01 0.283 0 0
HDACs deacetylate histones R-HSA-3214815 5.240781e-01 0.281 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.248149e-01 0.280 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.248149e-01 0.280 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.248149e-01 0.280 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.279544e-01 0.277 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.280983e-01 0.277 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.324663e-01 0.274 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.326116e-01 0.274 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.326116e-01 0.274 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.326116e-01 0.274 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.326116e-01 0.274 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.346306e-01 0.272 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.371236e-01 0.270 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.378553e-01 0.269 0 0
Interferon alpha/beta signaling R-HSA-909733 5.422841e-01 0.266 0 0
Ion homeostasis R-HSA-5578775 5.427806e-01 0.265 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.444181e-01 0.264 0 0
Platelet calcium homeostasis R-HSA-418360 5.445203e-01 0.264 0 0
2-LTR circle formation R-HSA-164843 5.447500e-01 0.264 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.447500e-01 0.264 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.447500e-01 0.264 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.447500e-01 0.264 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.447500e-01 0.264 0 0
Formation of apoptosome R-HSA-111458 5.447500e-01 0.264 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.477468e-01 0.261 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.477468e-01 0.261 0 0
FGFR2 alternative splicing R-HSA-6803529 5.531834e-01 0.257 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 5.531834e-01 0.257 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 5.531834e-01 0.257 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.535645e-01 0.257 0 0
Disorders of transmembrane transporters R-HSA-5619115 5.544304e-01 0.256 0 0
RUNX2 regulates bone development R-HSA-8941326 5.605575e-01 0.251 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.605575e-01 0.251 0 0
RNA Polymerase III Transcription R-HSA-74158 5.605575e-01 0.251 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.653328e-01 0.248 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.653328e-01 0.248 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.653328e-01 0.248 0 0
tRNA processing R-HSA-72306 5.681707e-01 0.246 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.692583e-01 0.245 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.692583e-01 0.245 0 0
HCN channels R-HSA-1296061 5.694142e-01 0.245 0 0
Nucleotide catabolism defects R-HSA-9735786 5.694142e-01 0.245 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 5.694142e-01 0.245 0 0
Signaling by LRP5 mutants R-HSA-5339717 5.694142e-01 0.245 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.694142e-01 0.245 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.694142e-01 0.245 0 0
Regulation of gap junction activity R-HSA-191650 5.694142e-01 0.245 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.694142e-01 0.245 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.694142e-01 0.245 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.694142e-01 0.245 0 0
NADE modulates death signalling R-HSA-205025 5.694142e-01 0.245 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.694142e-01 0.245 0 0
Interleukin-38 signaling R-HSA-9007892 5.694142e-01 0.245 0 0
Vasopressin-like receptors R-HSA-388479 5.694142e-01 0.245 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 5.806247e-01 0.236 0 0
Carnitine shuttle R-HSA-200425 5.806247e-01 0.236 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.806247e-01 0.236 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.840966e-01 0.234 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 5.847519e-01 0.233 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.847519e-01 0.233 0 0
Formation of the posterior neural plate R-HSA-9832991 5.847519e-01 0.233 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 5.847519e-01 0.233 0 0
Transport of RCbl within the body R-HSA-9758890 5.847519e-01 0.233 0 0
Synthesis of PI R-HSA-1483226 5.847519e-01 0.233 0 0
Dissolution of Fibrin Clot R-HSA-75205 5.847519e-01 0.233 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.894488e-01 0.230 0 0
G1 Phase R-HSA-69236 5.944437e-01 0.226 0 0
Cyclin D associated events in G1 R-HSA-69231 5.944437e-01 0.226 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.944437e-01 0.226 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.966106e-01 0.224 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.966106e-01 0.224 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.966106e-01 0.224 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.966106e-01 0.224 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 5.966106e-01 0.224 0 0
Peroxisomal protein import R-HSA-9033241 5.970534e-01 0.224 0 0
Circadian clock R-HSA-9909396 5.981171e-01 0.223 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.049183e-01 0.218 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 6.049183e-01 0.218 0 0
Neurexins and neuroligins R-HSA-6794361 6.049183e-01 0.218 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.049183e-01 0.218 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.070711e-01 0.217 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.070711e-01 0.217 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.103237e-01 0.214 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.141512e-01 0.212 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.144399e-01 0.212 0 0
Iron uptake and transport R-HSA-917937 6.159473e-01 0.210 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.159473e-01 0.210 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.165433e-01 0.210 0 0
G0 and Early G1 R-HSA-1538133 6.165433e-01 0.210 0 0
DNA strand elongation R-HSA-69190 6.165433e-01 0.210 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.165433e-01 0.210 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.220909e-01 0.206 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.220909e-01 0.206 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 6.220909e-01 0.206 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 6.220909e-01 0.206 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 6.220909e-01 0.206 0 0
Sodium/Calcium exchangers R-HSA-425561 6.220909e-01 0.206 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.231370e-01 0.205 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.243720e-01 0.205 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.258408e-01 0.204 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.258408e-01 0.204 0 0
NrCAM interactions R-HSA-447038 6.258408e-01 0.204 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.258408e-01 0.204 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.258408e-01 0.204 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.258408e-01 0.204 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 6.258408e-01 0.204 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.258408e-01 0.204 0 0
Defective F9 activation R-HSA-9673221 6.258408e-01 0.204 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.258408e-01 0.204 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.258408e-01 0.204 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.258408e-01 0.204 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 6.258408e-01 0.204 0 0
PTK6 Activates STAT3 R-HSA-8849474 6.258408e-01 0.204 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.258408e-01 0.204 0 0
Suppression of autophagy R-HSA-9636569 6.258408e-01 0.204 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.258408e-01 0.204 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.258408e-01 0.204 0 0
Co-inhibition by BTLA R-HSA-9927353 6.258408e-01 0.204 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.258408e-01 0.204 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.258408e-01 0.204 0 0
Mismatch Repair R-HSA-5358508 6.263792e-01 0.203 0 0
PKA activation R-HSA-163615 6.263792e-01 0.203 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.263792e-01 0.203 0 0
Tie2 Signaling R-HSA-210993 6.263792e-01 0.203 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.282704e-01 0.202 0 0
Base Excision Repair R-HSA-73884 6.322605e-01 0.199 0 0
TGFBR3 expression R-HSA-9839394 6.324705e-01 0.199 0 0
Tight junction interactions R-HSA-420029 6.324705e-01 0.199 0 0
HDMs demethylate histones R-HSA-3214842 6.324705e-01 0.199 0 0
Formation of the nephric duct R-HSA-9830364 6.324705e-01 0.199 0 0
Regulation of pyruvate metabolism R-HSA-9861718 6.333296e-01 0.198 0 0
Transmission across Chemical Synapses R-HSA-112315 6.433805e-01 0.192 0 0
Neuronal System R-HSA-112316 6.446127e-01 0.191 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.455460e-01 0.190 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.455460e-01 0.190 0 0
Generation of second messenger molecules R-HSA-202433 6.455460e-01 0.190 0 0
Glycogen metabolism R-HSA-8982491 6.455460e-01 0.190 0 0
Translation of Structural Proteins R-HSA-9694635 6.464339e-01 0.189 0 0
Signaling by PDGF R-HSA-186797 6.480182e-01 0.188 0 0
Heme signaling R-HSA-9707616 6.480182e-01 0.188 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.519537e-01 0.186 0 0
HCMV Late Events R-HSA-9610379 6.526551e-01 0.185 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.532945e-01 0.185 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.545992e-01 0.184 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.545992e-01 0.184 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.545992e-01 0.184 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.545992e-01 0.184 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.545992e-01 0.184 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.545992e-01 0.184 0 0
Other interleukin signaling R-HSA-449836 6.545992e-01 0.184 0 0
Maturation of nucleoprotein R-HSA-9694631 6.545992e-01 0.184 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 6.567779e-01 0.183 0 0
Scavenging by Class F Receptors R-HSA-3000484 6.567779e-01 0.183 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.567779e-01 0.183 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.567779e-01 0.183 0 0
MET activates RAS signaling R-HSA-8851805 6.567779e-01 0.183 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 6.567779e-01 0.183 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 6.567779e-01 0.183 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.567779e-01 0.183 0 0
OAS antiviral response R-HSA-8983711 6.567779e-01 0.183 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.567856e-01 0.183 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.567856e-01 0.183 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 6.567856e-01 0.183 0 0
Suppression of phagosomal maturation R-HSA-9637687 6.567856e-01 0.183 0 0
Immune System R-HSA-168256 6.629610e-01 0.179 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.629726e-01 0.179 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.672907e-01 0.176 0 0
Metal ion SLC transporters R-HSA-425410 6.700030e-01 0.174 0 0
Plus-strand DNA synthesis R-HSA-164525 6.748758e-01 0.171 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.748758e-01 0.171 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.748758e-01 0.171 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.748758e-01 0.171 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.748758e-01 0.171 0 0
Signaling by MST1 R-HSA-8852405 6.748758e-01 0.171 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.748758e-01 0.171 0 0
NGF-independant TRKA activation R-HSA-187024 6.748758e-01 0.171 0 0
PDE3B signalling R-HSA-165160 6.748758e-01 0.171 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.748758e-01 0.171 0 0
Phosphorylation of Emi1 R-HSA-176417 6.748758e-01 0.171 0 0
PKB-mediated events R-HSA-109703 6.748758e-01 0.171 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.748758e-01 0.171 0 0
Synthesis of PS R-HSA-1483101 6.748758e-01 0.171 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.748758e-01 0.171 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.748758e-01 0.171 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.748758e-01 0.171 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.748758e-01 0.171 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.748758e-01 0.171 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.748758e-01 0.171 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.748758e-01 0.171 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.799922e-01 0.167 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.799922e-01 0.167 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.799922e-01 0.167 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.799922e-01 0.167 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.812542e-01 0.167 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.812542e-01 0.167 0 0
Formation of definitive endoderm R-HSA-9823730 6.812542e-01 0.167 0 0
Protein hydroxylation R-HSA-9629569 6.812542e-01 0.167 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.813906e-01 0.167 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.813906e-01 0.167 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.813906e-01 0.167 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.840852e-01 0.165 0 0
HIV Transcription Initiation R-HSA-167161 6.840852e-01 0.165 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.840852e-01 0.165 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.874611e-01 0.163 0 0
Processing of SMDT1 R-HSA-8949664 6.888668e-01 0.162 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 6.888668e-01 0.162 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 6.888668e-01 0.162 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.888668e-01 0.162 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.978681e-01 0.156 0 0
G alpha (q) signalling events R-HSA-416476 6.988141e-01 0.156 0 0
PERK regulates gene expression R-HSA-381042 7.012855e-01 0.154 0 0
HIV elongation arrest and recovery R-HSA-167287 7.020777e-01 0.154 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.020777e-01 0.154 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.020777e-01 0.154 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.063467e-01 0.151 0 0
Lagging Strand Synthesis R-HSA-69186 7.063467e-01 0.151 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.063467e-01 0.151 0 0
Basigin interactions R-HSA-210991 7.063467e-01 0.151 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.100815e-01 0.149 0 0
Co-inhibition by PD-1 R-HSA-389948 7.158725e-01 0.145 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.174870e-01 0.144 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.174870e-01 0.144 0 0
Uncoating of the HIV Virion R-HSA-162585 7.174870e-01 0.144 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.174870e-01 0.144 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.174870e-01 0.144 0 0
CREB phosphorylation R-HSA-199920 7.174870e-01 0.144 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.174870e-01 0.144 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 7.174870e-01 0.144 0 0
NADPH regeneration R-HSA-389542 7.174870e-01 0.144 0 0
HDL clearance R-HSA-8964011 7.174870e-01 0.144 0 0
VLDL assembly R-HSA-8866423 7.174870e-01 0.144 0 0
Neurofascin interactions R-HSA-447043 7.174870e-01 0.144 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.184426e-01 0.144 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 7.184426e-01 0.144 0 0
Physiological factors R-HSA-5578768 7.184426e-01 0.144 0 0
Glycerophospholipid catabolism R-HSA-6814848 7.184426e-01 0.144 0 0
Malate-aspartate shuttle R-HSA-9856872 7.184426e-01 0.144 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.197777e-01 0.143 0 0
Meiotic recombination R-HSA-912446 7.205570e-01 0.142 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.230399e-01 0.141 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.230399e-01 0.141 0 0
G alpha (s) signalling events R-HSA-418555 7.254564e-01 0.139 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.294046e-01 0.137 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.298956e-01 0.137 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.298956e-01 0.137 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.298956e-01 0.137 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.298956e-01 0.137 0 0
Ribavirin ADME R-HSA-9755088 7.298956e-01 0.137 0 0
Potassium Channels R-HSA-1296071 7.351813e-01 0.134 0 0
Proteasome assembly R-HSA-9907900 7.365366e-01 0.133 0 0
DAP12 interactions R-HSA-2172127 7.365366e-01 0.133 0 0
Transcription of the HIV genome R-HSA-167172 7.381057e-01 0.132 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.384356e-01 0.132 0 0
Reproduction R-HSA-1474165 7.405906e-01 0.130 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.439206e-01 0.128 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 7.456128e-01 0.127 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 7.456128e-01 0.127 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.456128e-01 0.127 0 0
Formation of the anterior neural plate R-HSA-9823739 7.456128e-01 0.127 0 0
Telomere Maintenance R-HSA-157579 7.466180e-01 0.127 0 0
RSV-host interactions R-HSA-9833110 7.491605e-01 0.125 0 0
Cardiac conduction R-HSA-5576891 7.503399e-01 0.125 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.519327e-01 0.124 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.519327e-01 0.124 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.525689e-01 0.123 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.545157e-01 0.122 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.545157e-01 0.122 0 0
Recycling of eIF2:GDP R-HSA-72731 7.545157e-01 0.122 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.545157e-01 0.122 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.545157e-01 0.122 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 7.545157e-01 0.122 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.545157e-01 0.122 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.545157e-01 0.122 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.545157e-01 0.122 0 0
Ca2+ activated K+ channels R-HSA-1296052 7.545157e-01 0.122 0 0
LDL remodeling R-HSA-8964041 7.545157e-01 0.122 0 0
VLDL clearance R-HSA-8964046 7.545157e-01 0.122 0 0
Activation of TRKA receptors R-HSA-187015 7.545157e-01 0.122 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.545157e-01 0.122 0 0
CHL1 interactions R-HSA-447041 7.545157e-01 0.122 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.545157e-01 0.122 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.545157e-01 0.122 0 0
ABC transporter disorders R-HSA-5619084 7.648166e-01 0.116 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.657321e-01 0.116 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.669863e-01 0.115 0 0
Signaling by TGFBR3 R-HSA-9839373 7.678782e-01 0.115 0 0
HATs acetylate histones R-HSA-3214847 7.684948e-01 0.114 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 7.704999e-01 0.113 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 7.704999e-01 0.113 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.704999e-01 0.113 0 0
Activation of the phototransduction cascade R-HSA-2485179 7.704999e-01 0.113 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.704999e-01 0.113 0 0
Killing mechanisms R-HSA-9664420 7.704999e-01 0.113 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 7.704999e-01 0.113 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 7.720836e-01 0.112 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.720836e-01 0.112 0 0
Pentose phosphate pathway R-HSA-71336 7.720836e-01 0.112 0 0
Interleukin-20 family signaling R-HSA-8854691 7.725004e-01 0.112 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.725004e-01 0.112 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.725004e-01 0.112 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.770551e-01 0.110 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 7.775713e-01 0.109 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.792933e-01 0.108 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.824715e-01 0.107 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.866929e-01 0.104 0 0
Minus-strand DNA synthesis R-HSA-164516 7.866929e-01 0.104 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.866929e-01 0.104 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.866929e-01 0.104 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.866929e-01 0.104 0 0
MET receptor recycling R-HSA-8875656 7.866929e-01 0.104 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.866929e-01 0.104 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.866929e-01 0.104 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.866929e-01 0.104 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.866929e-01 0.104 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.866929e-01 0.104 0 0
Activation of RAS in B cells R-HSA-1169092 7.866929e-01 0.104 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.866929e-01 0.104 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.866929e-01 0.104 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.866929e-01 0.104 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.866929e-01 0.104 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 7.876195e-01 0.104 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.876195e-01 0.104 0 0
Pyruvate metabolism R-HSA-70268 7.879856e-01 0.103 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.886922e-01 0.103 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.909268e-01 0.102 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.916491e-01 0.101 0 0
Phase 2 - plateau phase R-HSA-5576893 7.932354e-01 0.101 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.932354e-01 0.101 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.932354e-01 0.101 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.932354e-01 0.101 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 7.932354e-01 0.101 0 0
Gluconeogenesis R-HSA-70263 7.963586e-01 0.099 0 0
Potential therapeutics for SARS R-HSA-9679191 7.987937e-01 0.098 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.990327e-01 0.097 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.094358e-01 0.092 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.094358e-01 0.092 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.094358e-01 0.092 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.114893e-01 0.091 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.139558e-01 0.089 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.139558e-01 0.089 0 0
Lipophagy R-HSA-9613354 8.146541e-01 0.089 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 8.146541e-01 0.089 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 8.146541e-01 0.089 0 0
mRNA Editing R-HSA-75072 8.146541e-01 0.089 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 8.146541e-01 0.089 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.146541e-01 0.089 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.146541e-01 0.089 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.146541e-01 0.089 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.146541e-01 0.089 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 8.146541e-01 0.089 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.162003e-01 0.088 0 0
Mitochondrial biogenesis R-HSA-1592230 8.176421e-01 0.087 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.190490e-01 0.087 0 0
DNA Replication R-HSA-69306 8.216387e-01 0.085 0 0
Azathioprine ADME R-HSA-9748787 8.220673e-01 0.085 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.260879e-01 0.083 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.278354e-01 0.082 0 0
Regulation of beta-cell development R-HSA-186712 8.284123e-01 0.082 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.292886e-01 0.081 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.292886e-01 0.081 0 0
Depyrimidination R-HSA-73928 8.292886e-01 0.081 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.317236e-01 0.080 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.327985e-01 0.079 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 8.327985e-01 0.079 0 0
Parasite infection R-HSA-9664407 8.345565e-01 0.079 0 0
Leishmania phagocytosis R-HSA-9664417 8.345565e-01 0.079 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.345565e-01 0.079 0 0
Binding and entry of HIV virion R-HSA-173107 8.389514e-01 0.076 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.389514e-01 0.076 0 0
DNA replication initiation R-HSA-68952 8.389514e-01 0.076 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.389514e-01 0.076 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.389514e-01 0.076 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.389514e-01 0.076 0 0
Maturation of spike protein R-HSA-9683686 8.389514e-01 0.076 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.389514e-01 0.076 0 0
Cristae formation R-HSA-8949613 8.411705e-01 0.075 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.411705e-01 0.075 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.454999e-01 0.073 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.495038e-01 0.071 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.498997e-01 0.071 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.498997e-01 0.071 0 0
Specification of the neural plate border R-HSA-9834899 8.498997e-01 0.071 0 0
Diseases of hemostasis R-HSA-9671793 8.498997e-01 0.071 0 0
RNA Polymerase I Transcription R-HSA-73864 8.505309e-01 0.070 0 0
ABC-family proteins mediated transport R-HSA-382556 8.519700e-01 0.070 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.524728e-01 0.069 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.543032e-01 0.068 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.552488e-01 0.068 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.552488e-01 0.068 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.552488e-01 0.068 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.557174e-01 0.068 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 8.592894e-01 0.066 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.600648e-01 0.065 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.600648e-01 0.065 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.600648e-01 0.065 0 0
vRNP Assembly R-HSA-192905 8.600648e-01 0.065 0 0
vRNA Synthesis R-HSA-192814 8.600648e-01 0.065 0 0
Chylomicron assembly R-HSA-8963888 8.600648e-01 0.065 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.600648e-01 0.065 0 0
Prostanoid ligand receptors R-HSA-391908 8.600648e-01 0.065 0 0
Mitochondrial protein degradation R-HSA-9837999 8.617230e-01 0.065 0 0
Somitogenesis R-HSA-9824272 8.640504e-01 0.063 0 0
Voltage gated Potassium channels R-HSA-1296072 8.643398e-01 0.063 0 0
SLC-mediated transport of organic cations R-HSA-549127 8.643398e-01 0.063 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.653920e-01 0.063 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.653920e-01 0.063 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.653920e-01 0.063 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.653920e-01 0.063 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.653920e-01 0.063 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.657017e-01 0.063 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.742302e-01 0.058 0 0
MET promotes cell motility R-HSA-8875878 8.753785e-01 0.058 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.753785e-01 0.058 0 0
Depurination R-HSA-73927 8.753785e-01 0.058 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.784113e-01 0.056 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.784113e-01 0.056 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.784113e-01 0.056 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.784113e-01 0.056 0 0
FMO oxidises nucleophiles R-HSA-217271 8.784113e-01 0.056 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.784113e-01 0.056 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.784113e-01 0.056 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.784113e-01 0.056 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.784113e-01 0.056 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.794034e-01 0.056 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.801593e-01 0.055 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 8.801593e-01 0.055 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.801593e-01 0.055 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.822165e-01 0.054 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.822165e-01 0.054 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.822165e-01 0.054 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.839504e-01 0.054 0 0
FCERI mediated MAPK activation R-HSA-2871796 8.853617e-01 0.053 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.856312e-01 0.053 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 8.865433e-01 0.052 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.911235e-01 0.050 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.920558e-01 0.050 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.943533e-01 0.048 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.943533e-01 0.048 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.943533e-01 0.048 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.951399e-01 0.048 0 0
HIV Transcription Elongation R-HSA-167169 8.951399e-01 0.048 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.951399e-01 0.048 0 0
Ion channel transport R-HSA-983712 8.978547e-01 0.047 0 0
GPCR downstream signalling R-HSA-388396 9.004479e-01 0.046 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.011793e-01 0.045 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.034645e-01 0.044 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.034645e-01 0.044 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.034645e-01 0.044 0 0
LDL clearance R-HSA-8964038 9.034645e-01 0.044 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.039463e-01 0.044 0 0
Maturation of spike protein R-HSA-9694548 9.039463e-01 0.044 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.082059e-01 0.042 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.082059e-01 0.042 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 9.082059e-01 0.042 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.082059e-01 0.042 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.082059e-01 0.042 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.082059e-01 0.042 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.082059e-01 0.042 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.082059e-01 0.042 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.082059e-01 0.042 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.087021e-01 0.042 0 0
Nuclear RNA decay R-HSA-9930044 9.103890e-01 0.041 0 0
Cardiogenesis R-HSA-9733709 9.103890e-01 0.041 0 0
Intra-Golgi traffic R-HSA-6811438 9.120914e-01 0.040 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.137382e-01 0.039 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.137382e-01 0.039 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.137382e-01 0.039 0 0
Formation of the cornified envelope R-HSA-6809371 9.159351e-01 0.038 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.188121e-01 0.037 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.188121e-01 0.037 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.188121e-01 0.037 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.196151e-01 0.036 0 0
COPII-mediated vesicle transport R-HSA-204005 9.198901e-01 0.036 0 0
Prolactin receptor signaling R-HSA-1170546 9.202428e-01 0.036 0 0
Removal of the Flap Intermediate R-HSA-69166 9.202428e-01 0.036 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.202428e-01 0.036 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.202428e-01 0.036 0 0
Hydrolysis of LPC R-HSA-1483115 9.202428e-01 0.036 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 9.202428e-01 0.036 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 9.202428e-01 0.036 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 9.202428e-01 0.036 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 9.202428e-01 0.036 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.202428e-01 0.036 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.202428e-01 0.036 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.202428e-01 0.036 0 0
Zinc transporters R-HSA-435354 9.202428e-01 0.036 0 0
P2Y receptors R-HSA-417957 9.202428e-01 0.036 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.226078e-01 0.035 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.265060e-01 0.033 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.265777e-01 0.033 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.265777e-01 0.033 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.307020e-01 0.031 0 0
Processive synthesis on the lagging strand R-HSA-69183 9.307020e-01 0.031 0 0
Protein lipoylation R-HSA-9857492 9.307020e-01 0.031 0 0
DNA Damage Reversal R-HSA-73942 9.307020e-01 0.031 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.307020e-01 0.031 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 9.307020e-01 0.031 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.312790e-01 0.031 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.321536e-01 0.031 0 0
Amine ligand-binding receptors R-HSA-375280 9.329526e-01 0.030 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.338400e-01 0.030 0 0
Innate Immune System R-HSA-168249 9.377765e-01 0.028 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.387279e-01 0.027 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.387279e-01 0.027 0 0
Urea cycle R-HSA-70635 9.387279e-01 0.027 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 9.387279e-01 0.027 0 0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 9.397901e-01 0.027 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.397901e-01 0.027 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.397901e-01 0.027 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.397901e-01 0.027 0 0
Synthesis of wybutosine at G37 of tRNA(Phe) R-HSA-6782861 9.397901e-01 0.027 0 0
Atorvastatin ADME R-HSA-9754706 9.397901e-01 0.027 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.397901e-01 0.027 0 0
Attachment and Entry R-HSA-9678110 9.397901e-01 0.027 0 0
G1/S-Specific Transcription R-HSA-69205 9.399212e-01 0.027 0 0
Triglyceride catabolism R-HSA-163560 9.399212e-01 0.027 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.417701e-01 0.026 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.433415e-01 0.025 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.442528e-01 0.025 0 0
Packaging Of Telomere Ends R-HSA-171306 9.454055e-01 0.024 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.454055e-01 0.024 0 0
Insulin processing R-HSA-264876 9.454055e-01 0.024 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.454055e-01 0.024 0 0
Cleavage of the damaged purine R-HSA-110331 9.457430e-01 0.024 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 9.476867e-01 0.023 0 0
Glycine degradation R-HSA-6783984 9.476867e-01 0.023 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.476867e-01 0.023 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 9.476867e-01 0.023 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.476867e-01 0.023 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.479182e-01 0.023 0 0
Infectious disease R-HSA-5663205 9.500085e-01 0.022 0 0
PPARA activates gene expression R-HSA-1989781 9.506751e-01 0.022 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.510365e-01 0.022 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.513861e-01 0.022 0 0
Phospholipid metabolism R-HSA-1483257 9.531144e-01 0.021 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.537157e-01 0.021 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.545481e-01 0.020 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.545481e-01 0.020 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.545481e-01 0.020 0 0
Uptake and function of anthrax toxins R-HSA-5210891 9.545481e-01 0.020 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.557492e-01 0.020 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.557492e-01 0.020 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.558447e-01 0.020 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.559355e-01 0.020 0 0
Integrin cell surface interactions R-HSA-216083 9.564547e-01 0.019 0 0
mRNA Capping R-HSA-72086 9.567375e-01 0.019 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.605100e-01 0.017 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.605100e-01 0.017 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.605100e-01 0.017 0 0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 9.605100e-01 0.017 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.605100e-01 0.017 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.612239e-01 0.017 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.651423e-01 0.015 0 0
The phototransduction cascade R-HSA-2514856 9.652987e-01 0.015 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.656901e-01 0.015 0 0
Pyrimidine biosynthesis R-HSA-500753 9.656901e-01 0.015 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.656901e-01 0.015 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.656901e-01 0.015 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.656901e-01 0.015 0 0
Protein localization R-HSA-9609507 9.664372e-01 0.015 0 0
Mitochondrial protein import R-HSA-1268020 9.675984e-01 0.014 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.676819e-01 0.014 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.684865e-01 0.014 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.701909e-01 0.013 0 0
Melanin biosynthesis R-HSA-5662702 9.701909e-01 0.013 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.701909e-01 0.013 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.701909e-01 0.013 0 0
Creatine metabolism R-HSA-71288 9.701909e-01 0.013 0 0
Pregnenolone biosynthesis R-HSA-196108 9.701909e-01 0.013 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.701909e-01 0.013 0 0
Ion transport by P-type ATPases R-HSA-936837 9.729922e-01 0.012 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.730139e-01 0.012 0 0
Recycling of bile acids and salts R-HSA-159418 9.730139e-01 0.012 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.741016e-01 0.011 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.741016e-01 0.011 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.741016e-01 0.011 0 0
Phenylalanine metabolism R-HSA-8964208 9.741016e-01 0.011 0 0
Abacavir metabolism R-HSA-2161541 9.741016e-01 0.011 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.741016e-01 0.011 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.741016e-01 0.011 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.760474e-01 0.011 0 0
Heme degradation R-HSA-189483 9.760474e-01 0.011 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.765695e-01 0.010 0 0
Serine metabolism R-HSA-977347 9.774994e-01 0.010 0 0
Glutathione synthesis and recycling R-HSA-174403 9.774994e-01 0.010 0 0
Attachment and Entry R-HSA-9694614 9.774994e-01 0.010 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.775414e-01 0.010 0 0
eNOS activation R-HSA-203615 9.787496e-01 0.009 0 0
Hyaluronan metabolism R-HSA-2142845 9.787496e-01 0.009 0 0
Developmental Cell Lineages R-HSA-9734767 9.795731e-01 0.009 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.804516e-01 0.009 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.804516e-01 0.009 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.811553e-01 0.008 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.815293e-01 0.008 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.815293e-01 0.008 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.830166e-01 0.007 0 0
Biosynthesis of maresins R-HSA-9018682 9.830166e-01 0.007 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.830644e-01 0.007 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.832957e-01 0.007 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.845740e-01 0.007 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.851990e-01 0.006 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.851990e-01 0.006 0 0
CYP2E1 reactions R-HSA-211999 9.852452e-01 0.006 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.852452e-01 0.006 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.852452e-01 0.006 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.852452e-01 0.006 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.852452e-01 0.006 0 0
RAB geranylgeranylation R-HSA-8873719 9.857860e-01 0.006 0 0
tRNA Aminoacylation R-HSA-379724 9.857860e-01 0.006 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.859753e-01 0.006 0 0
Metabolism of cofactors R-HSA-8978934 9.859753e-01 0.006 0 0
Gastrulation R-HSA-9758941 9.863197e-01 0.006 0 0
Interferon gamma signaling R-HSA-877300 9.870682e-01 0.006 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.871815e-01 0.006 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.871815e-01 0.006 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.871815e-01 0.006 0 0
Hyaluronan degradation R-HSA-2160916 9.871815e-01 0.006 0 0
Laminin interactions R-HSA-3000157 9.871815e-01 0.006 0 0
G alpha (i) signalling events R-HSA-418594 9.880385e-01 0.005 0 0
Signaling by GPCR R-HSA-372790 9.881216e-01 0.005 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.883932e-01 0.005 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.884251e-01 0.005 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.888637e-01 0.005 0 0
Sphingolipid catabolism R-HSA-9845614 9.888637e-01 0.005 0 0
Abacavir ADME R-HSA-2161522 9.888637e-01 0.005 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.888637e-01 0.005 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.894796e-01 0.005 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.902386e-01 0.004 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.903253e-01 0.004 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.903253e-01 0.004 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.903253e-01 0.004 0 0
Insulin receptor recycling R-HSA-77387 9.915951e-01 0.004 0 0
Pyrimidine salvage R-HSA-73614 9.915951e-01 0.004 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.919616e-01 0.004 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.919616e-01 0.004 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.923868e-01 0.003 0 0
DNA methylation R-HSA-5334118 9.926983e-01 0.003 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.928927e-01 0.003 0 0
Paracetamol ADME R-HSA-9753281 9.930240e-01 0.003 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.931045e-01 0.003 0 0
Kidney development R-HSA-9830369 9.931045e-01 0.003 0 0
Disease R-HSA-1643685 9.931803e-01 0.003 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.935668e-01 0.003 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.936568e-01 0.003 0 0
Neurotransmitter clearance R-HSA-112311 9.936568e-01 0.003 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.939399e-01 0.003 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.941759e-01 0.003 0 0
Synthesis of PA R-HSA-1483166 9.944351e-01 0.002 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.944895e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.944895e-01 0.002 0 0
Cargo concentration in the ER R-HSA-5694530 9.944895e-01 0.002 0 0
Amyloid fiber formation R-HSA-977225 9.947296e-01 0.002 0 0
DAG1 glycosylations R-HSA-8931838 9.952129e-01 0.002 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.954833e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.954833e-01 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.955676e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.955676e-01 0.002 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.955676e-01 0.002 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.956699e-01 0.002 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.958414e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.960464e-01 0.002 0 0
Synthesis of PC R-HSA-1483191 9.961772e-01 0.002 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.963874e-01 0.002 0 0
Endogenous sterols R-HSA-211976 9.964748e-01 0.002 0 0
Post-translational protein modification R-HSA-597592 9.965298e-01 0.002 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.968618e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.972739e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.972739e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.972739e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.973843e-01 0.001 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.976318e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.976318e-01 0.001 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.979429e-01 0.001 0 0
Ubiquinol biosynthesis R-HSA-2142789 9.979429e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.979429e-01 0.001 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.979429e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.979429e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.980032e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.981638e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.981995e-01 0.001 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.981995e-01 0.001 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.982130e-01 0.001 0 0
Purine salvage R-HSA-74217 9.982130e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.982130e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.982406e-01 0.001 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.984477e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.986516e-01 0.001 0 0
Tryptophan catabolism R-HSA-71240 9.986516e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.986516e-01 0.001 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.988287e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.988287e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.988612e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.988750e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.989151e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.992158e-01 0.000 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.992324e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.992330e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.992596e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.993149e-01 0.000 0 0
Methylation R-HSA-156581 9.993332e-01 0.000 0 0
Surfactant metabolism R-HSA-5683826 9.993332e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.993332e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.993483e-01 0.000 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.994208e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.994208e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.995000e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.995562e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.996205e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.996704e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.996704e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.996983e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.997137e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.997348e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.997348e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.997513e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.997513e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998200e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.998371e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.998470e-01 0.000 0 0
Keratinization R-HSA-6805567 9.998669e-01 0.000 0 0
Digestion R-HSA-8935690 9.998771e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.998780e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.998950e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999133e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.999195e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999201e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999259e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.999275e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999275e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.999301e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999364e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999440e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999542e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999602e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999629e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999669e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999702e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999739e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999834e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999846e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999848e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999852e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999871e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999875e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999888e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999903e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999945e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999964e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999964e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999982e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999985e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999986e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999989e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999989e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999993e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999994e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999995e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999996e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999997e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999998e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999999e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 1 0
Cell Cycle, Mitotic R-HSA-69278 1.110223e-16 15.955 1 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 2.220446e-16 15.654 0 0
M Phase R-HSA-68886 7.760459e-14 13.110 1 0
HSF1-dependent transactivation R-HSA-3371571 7.207568e-13 12.142 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.669553e-12 11.777 0 0
Attenuation phase R-HSA-3371568 9.179657e-12 11.037 0 0
Axon guidance R-HSA-422475 1.266676e-11 10.897 0 0
Cell Cycle Checkpoints R-HSA-69620 2.004752e-11 10.698 0 0
HSF1 activation R-HSA-3371511 1.901074e-10 9.721 0 0
G2/M Checkpoints R-HSA-69481 2.764045e-10 9.558 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.967890e-10 9.528 0 0
Nervous system development R-HSA-9675108 3.299456e-10 9.482 0 0
Membrane Trafficking R-HSA-199991 4.079044e-10 9.389 0 0
Metabolism of RNA R-HSA-8953854 9.561630e-10 9.019 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.307723e-09 8.883 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.307723e-09 8.883 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.446514e-09 8.840 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.446514e-09 8.840 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.140265e-09 8.670 0 0
Mitotic Prophase R-HSA-68875 3.502660e-09 8.456 0 0
Cell-Cell communication R-HSA-1500931 3.424325e-09 8.465 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.895293e-09 8.409 0 0
Translation initiation complex formation R-HSA-72649 4.025839e-09 8.395 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.921219e-09 8.308 0 0
Deubiquitination R-HSA-5688426 4.915227e-09 8.308 0 0
SARS-CoV-2-host interactions R-HSA-9705683 5.892208e-09 8.230 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.003013e-08 7.999 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.485069e-08 7.828 0 0
G2/M Transition R-HSA-69275 1.695397e-08 7.771 1 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.781253e-08 7.749 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.331878e-08 7.632 1 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.975607e-08 7.526 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.307748e-08 7.480 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.964523e-08 7.402 0 0
Homology Directed Repair R-HSA-5693538 5.166768e-08 7.287 0 0
SARS-CoV-1-host interactions R-HSA-9692914 6.429030e-08 7.192 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.687438e-08 7.175 0 0
Influenza Infection R-HSA-168255 7.598917e-08 7.119 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.954090e-08 7.099 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.138738e-07 6.944 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.282892e-07 6.892 0 0
Peptide chain elongation R-HSA-156902 1.373940e-07 6.862 0 0
PKR-mediated signaling R-HSA-9833482 1.555750e-07 6.808 0 0
Nucleosome assembly R-HSA-774815 1.873824e-07 6.727 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.873824e-07 6.727 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.804815e-07 6.744 0 0
Separation of Sister Chromatids R-HSA-2467813 1.962662e-07 6.707 0 0
Cell junction organization R-HSA-446728 2.098392e-07 6.678 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.460727e-07 6.609 0 0
Mitotic Prometaphase R-HSA-68877 2.646625e-07 6.577 1 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.729302e-07 6.564 0 0
Mitotic Anaphase R-HSA-68882 3.046015e-07 6.516 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.177547e-07 6.498 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.478689e-07 6.459 0 0
Recycling pathway of L1 R-HSA-437239 3.522082e-07 6.453 0 0
Ub-specific processing proteases R-HSA-5689880 3.861690e-07 6.413 0 0
Adherens junctions interactions R-HSA-418990 3.968740e-07 6.401 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.147263e-07 6.382 0 0
Cellular Senescence R-HSA-2559583 4.710541e-07 6.327 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.940813e-07 6.306 0 0
Signaling by ROBO receptors R-HSA-376176 4.787574e-07 6.320 0 0
Ribosome-associated quality control R-HSA-9948299 4.979624e-07 6.303 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.778886e-07 6.238 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.778886e-07 6.238 0 0
Signal Transduction R-HSA-162582 5.955381e-07 6.225 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 6.523693e-07 6.186 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.524184e-07 6.185 0 0
L1CAM interactions R-HSA-373760 6.663076e-07 6.176 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.435033e-07 6.129 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.007985e-07 6.096 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.160156e-07 6.088 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 8.673443e-07 6.062 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.434282e-07 6.025 0 0
Selective autophagy R-HSA-9663891 1.168993e-06 5.932 0 0
Cell-cell junction organization R-HSA-421270 1.245664e-06 5.905 0 0
Aggrephagy R-HSA-9646399 1.532758e-06 5.815 0 0
Interferon Signaling R-HSA-913531 1.532984e-06 5.814 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.599213e-06 5.796 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.757808e-06 5.755 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.959282e-06 5.708 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.959282e-06 5.708 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.085157e-06 5.681 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.152802e-06 5.667 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.258088e-06 5.646 0 0
Apoptotic execution phase R-HSA-75153 3.378827e-06 5.471 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.563054e-06 5.448 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 4.040883e-06 5.394 0 0
Apoptosis R-HSA-109581 4.030722e-06 5.395 0 0
Viral mRNA Translation R-HSA-192823 4.263498e-06 5.370 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.655214e-06 5.332 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.937979e-06 5.306 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.700060e-06 5.244 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.787011e-06 5.238 0 0
DNA Double Strand Break Response R-HSA-5693606 6.010751e-06 5.221 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.451610e-06 5.190 0 0
Eukaryotic Translation Termination R-HSA-72764 6.729020e-06 5.172 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 6.870613e-06 5.163 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.308916e-06 5.136 0 0
Selenocysteine synthesis R-HSA-2408557 7.636404e-06 5.117 0 0
Vesicle-mediated transport R-HSA-5653656 8.904662e-06 5.050 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.005789e-05 4.997 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.005789e-05 4.997 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.012692e-05 4.995 0 0
Signaling by RAS mutants R-HSA-6802949 1.143739e-05 4.942 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.143739e-05 4.942 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.143739e-05 4.942 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.143739e-05 4.942 0 0
Kinesins R-HSA-983189 1.106485e-05 4.956 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.180337e-05 4.928 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.233649e-05 4.909 0 0
Meiotic recombination R-HSA-912446 1.253614e-05 4.902 0 0
Signaling by WNT R-HSA-195721 1.285301e-05 4.891 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.406345e-05 4.852 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.510492e-05 4.821 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.599019e-05 4.796 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.856132e-05 4.731 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.995099e-05 4.700 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.407139e-05 4.618 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.411954e-05 4.618 0 0
Gap junction trafficking and regulation R-HSA-157858 2.429285e-05 4.615 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.557212e-05 4.592 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.769428e-05 4.558 0 0
Viral Infection Pathways R-HSA-9824446 2.861517e-05 4.543 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.525999e-05 4.344 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.650352e-05 4.333 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.962022e-05 4.304 0 0
Post NMDA receptor activation events R-HSA-438064 4.884015e-05 4.311 0 0
Regulation of CDH1 Function R-HSA-9764561 4.967671e-05 4.304 0 0
Chromosome Maintenance R-HSA-73886 4.971900e-05 4.303 0 0
COPI-mediated anterograde transport R-HSA-6807878 4.996536e-05 4.301 0 0
Cellular response to starvation R-HSA-9711097 5.004317e-05 4.301 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 5.152139e-05 4.288 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.427643e-05 4.265 0 0
Packaging Of Telomere Ends R-HSA-171306 5.564308e-05 4.255 0 0
Meiotic synapsis R-HSA-1221632 6.093777e-05 4.215 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.786001e-05 4.238 1 1
DNA Replication R-HSA-69306 5.628933e-05 4.250 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.175258e-05 4.209 1 1
S Phase R-HSA-69242 6.327058e-05 4.199 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.663854e-05 4.176 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.663854e-05 4.176 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.809854e-05 4.167 0 0
Gap junction trafficking R-HSA-190828 7.148675e-05 4.146 0 0
Meiosis R-HSA-1500620 7.326432e-05 4.135 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.813936e-05 4.107 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.214990e-05 4.085 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.330276e-05 4.079 0 0
ISG15 antiviral mechanism R-HSA-1169408 8.255589e-05 4.083 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.993749e-05 4.046 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.029040e-05 4.044 0 0
DNA Repair R-HSA-73894 9.066941e-05 4.043 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.231194e-05 4.035 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.860438e-05 4.006 0 0
Programmed Cell Death R-HSA-5357801 9.866280e-05 4.006 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.012939e-04 3.994 0 0
DNA methylation R-HSA-5334118 1.023530e-04 3.990 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.026553e-04 3.989 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.098689e-04 3.959 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.098689e-04 3.959 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.222470e-04 3.913 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.135012e-04 3.945 0 0
rRNA processing R-HSA-72312 1.164695e-04 3.934 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.146997e-04 3.940 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.222470e-04 3.913 0 0
Gene Silencing by RNA R-HSA-211000 1.310590e-04 3.883 0 0
RNA Polymerase I Transcription R-HSA-73864 1.392656e-04 3.856 0 0
Chromatin modifying enzymes R-HSA-3247509 1.404656e-04 3.852 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.542053e-04 3.812 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.571216e-04 3.804 0 0
Autophagy R-HSA-9612973 1.628378e-04 3.788 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.678446e-04 3.775 0 0
Chromatin organization R-HSA-4839726 1.701411e-04 3.769 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.779293e-04 3.750 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.793759e-04 3.746 0 0
HATs acetylate histones R-HSA-3214847 1.847118e-04 3.734 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.941864e-04 3.712 0 0
G1/S Transition R-HSA-69206 2.092809e-04 3.679 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.236201e-04 3.650 0 0
HCMV Early Events R-HSA-9609690 2.396047e-04 3.621 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.478315e-04 3.606 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 2.649908e-04 3.577 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.692172e-04 3.570 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.730739e-04 3.564 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.854253e-04 3.545 0 0
Protein folding R-HSA-391251 3.006590e-04 3.522 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.036148e-04 3.518 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.108597e-04 3.507 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.137468e-04 3.503 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.141718e-04 3.503 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.223824e-04 3.492 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.223824e-04 3.492 0 0
Cleavage of the damaged purine R-HSA-110331 3.223824e-04 3.492 0 0
Host Interactions of HIV factors R-HSA-162909 3.408546e-04 3.467 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.889679e-04 3.410 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.948826e-04 3.404 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.697299e-04 3.432 0 0
Signaling by Hippo R-HSA-2028269 3.632402e-04 3.440 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.889679e-04 3.410 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.943836e-04 3.404 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.988302e-04 3.399 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.919101e-04 3.407 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.784543e-04 3.422 0 0
SARS-CoV Infections R-HSA-9679506 4.051016e-04 3.392 0 0
Depurination R-HSA-73927 4.057392e-04 3.392 0 0
Macroautophagy R-HSA-1632852 4.202251e-04 3.377 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.642265e-04 3.333 0 0
Signaling by TGFB family members R-HSA-9006936 4.873880e-04 3.312 0 0
Nuclear import of Rev protein R-HSA-180746 4.940142e-04 3.306 0 0
Defective pyroptosis R-HSA-9710421 5.063436e-04 3.296 0 0
Protein ubiquitination R-HSA-8852135 5.084188e-04 3.294 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.265414e-04 3.279 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.265414e-04 3.279 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.269525e-04 3.278 0 0
Metalloprotease DUBs R-HSA-5689901 5.459857e-04 3.263 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.961443e-04 3.225 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.961443e-04 3.225 0 0
Signaling by ERBB2 R-HSA-1227986 6.444841e-04 3.191 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.203580e-04 3.207 0 0
Signaling by ALK in cancer R-HSA-9700206 6.203580e-04 3.207 0 0
Co-inhibition by PD-1 R-HSA-389948 6.350411e-04 3.197 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.289026e-04 3.201 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.289026e-04 3.201 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.137132e-04 3.212 0 0
MHC class II antigen presentation R-HSA-2132295 6.190369e-04 3.208 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.444841e-04 3.191 0 0
Gap junction degradation R-HSA-190873 6.557152e-04 3.183 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.622574e-04 3.179 0 0
EPH-Ephrin signaling R-HSA-2682334 6.733029e-04 3.172 0 0
HIV Life Cycle R-HSA-162587 6.801745e-04 3.167 0 0
HIV Infection R-HSA-162906 7.457542e-04 3.127 0 0
Repression of WNT target genes R-HSA-4641265 7.501812e-04 3.125 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.831816e-04 3.054 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.004380e-04 3.046 0 0
MAP2K and MAPK activation R-HSA-5674135 9.489637e-04 3.023 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 9.545624e-04 3.020 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 9.562135e-04 3.019 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 9.647175e-04 3.016 0 0
ESR-mediated signaling R-HSA-8939211 9.803591e-04 3.009 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 9.846532e-04 3.007 1 1
Base Excision Repair R-HSA-73884 9.846532e-04 3.007 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.009894e-03 2.996 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.038292e-03 2.984 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.100456e-03 2.958 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.101047e-03 2.958 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.101047e-03 2.958 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.154802e-03 2.937 0 0
Depyrimidination R-HSA-73928 1.154802e-03 2.937 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.188173e-03 2.925 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.195503e-03 2.922 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.364483e-03 2.865 0 0
Regulation of PTEN localization R-HSA-8948747 1.364483e-03 2.865 0 0
Metabolism of non-coding RNA R-HSA-194441 1.352368e-03 2.869 0 0
snRNP Assembly R-HSA-191859 1.352368e-03 2.869 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.290812e-03 2.889 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.396994e-03 2.855 0 0
Signaling by NOTCH R-HSA-157118 1.239422e-03 2.907 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.453432e-03 2.838 0 0
Telomere Maintenance R-HSA-157579 1.458596e-03 2.836 0 0
Cilium Assembly R-HSA-5617833 1.463680e-03 2.835 1 0
RAF activation R-HSA-5673000 1.482720e-03 2.829 0 0
Dual Incision in GG-NER R-HSA-5696400 1.482720e-03 2.829 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.482720e-03 2.829 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.518692e-03 2.819 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.518692e-03 2.819 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.577876e-03 2.802 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.578196e-03 2.802 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.578196e-03 2.802 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.607509e-03 2.794 0 0
Diseases of programmed cell death R-HSA-9645723 1.635982e-03 2.786 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.674769e-03 2.776 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.680371e-03 2.775 1 1
EPHB-mediated forward signaling R-HSA-3928662 1.680401e-03 2.775 0 0
mRNA Splicing R-HSA-72172 1.700948e-03 2.769 0 0
HDACs deacetylate histones R-HSA-3214815 1.729278e-03 2.762 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.752936e-03 2.756 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.805229e-03 2.743 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.824952e-03 2.739 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.839443e-03 2.735 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.879580e-03 2.726 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.946871e-03 2.711 0 0
Ephrin signaling R-HSA-3928664 1.947479e-03 2.711 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.017117e-03 2.695 1 1
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.030366e-03 2.692 0 0
Signaling by EGFR R-HSA-177929 2.030366e-03 2.692 0 0
Nucleotide Excision Repair R-HSA-5696398 2.059509e-03 2.686 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.133255e-03 2.671 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.186707e-03 2.660 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.186707e-03 2.660 0 0
Formation of annular gap junctions R-HSA-196025 2.190926e-03 2.659 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.274006e-03 2.643 0 0
G0 and Early G1 R-HSA-1538133 2.284021e-03 2.641 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.284021e-03 2.641 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.378954e-03 2.624 0 0
Integrin signaling R-HSA-354192 2.809049e-03 2.551 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.498030e-03 2.602 1 1
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.498030e-03 2.602 1 1
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.969279e-03 2.527 0 0
Centrosome maturation R-HSA-380287 2.647284e-03 2.577 1 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.705899e-03 2.568 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.969279e-03 2.527 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.705899e-03 2.568 0 0
Amyloid fiber formation R-HSA-977225 2.680560e-03 2.572 0 0
UCH proteinases R-HSA-5689603 3.019732e-03 2.520 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.290692e-03 2.483 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.290692e-03 2.483 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.323067e-03 2.478 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.347904e-03 2.475 0 0
Nephrin family interactions R-HSA-373753 3.360665e-03 2.474 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.432134e-03 2.464 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.432134e-03 2.464 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.527736e-03 2.453 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.552719e-03 2.449 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.708922e-03 2.431 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.708922e-03 2.431 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.708922e-03 2.431 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.708922e-03 2.431 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.708922e-03 2.431 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.753749e-03 2.426 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.773404e-03 2.423 0 0
DNA Damage Bypass R-HSA-73893 3.914279e-03 2.407 0 0
HCMV Infection R-HSA-9609646 4.145677e-03 2.382 0 0
Mitophagy R-HSA-5205647 4.152556e-03 2.382 0 0
Selenoamino acid metabolism R-HSA-2408522 4.189499e-03 2.378 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.318694e-03 2.365 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.318694e-03 2.365 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.456425e-03 2.351 0 0
Rab regulation of trafficking R-HSA-9007101 4.632507e-03 2.334 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.664598e-03 2.331 0 0
tRNA processing in the nucleus R-HSA-6784531 4.903486e-03 2.309 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.907635e-03 2.309 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.907635e-03 2.309 0 0
Pexophagy R-HSA-9664873 4.907635e-03 2.309 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.976095e-03 2.303 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.995055e-03 2.301 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.074038e-03 2.295 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.465959e-03 2.262 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.477288e-03 2.261 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.477288e-03 2.261 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.507376e-03 2.259 0 0
MAPK family signaling cascades R-HSA-5683057 5.756332e-03 2.240 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.885949e-03 2.230 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.968460e-03 2.224 0 0
FLT3 signaling in disease R-HSA-9682385 5.968460e-03 2.224 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.150574e-03 2.211 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.294223e-03 2.201 0 0
Dual incision in TC-NER R-HSA-6782135 6.312791e-03 2.200 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.411156e-03 2.193 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.182556e-03 2.144 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.662330e-03 2.116 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.849200e-03 2.164 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 7.087893e-03 2.149 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.662330e-03 2.116 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.662330e-03 2.116 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.086277e-03 2.150 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.662330e-03 2.116 0 0
DCC mediated attractive signaling R-HSA-418885 8.132234e-03 2.090 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.662330e-03 2.116 0 0
Gene expression (Transcription) R-HSA-74160 6.869670e-03 2.163 0 0
Activation of HOX genes during differentiation R-HSA-5619507 6.952405e-03 2.158 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.952405e-03 2.158 0 0
Translation R-HSA-72766 6.857264e-03 2.164 0 0
p75NTR signals via NF-kB R-HSA-193639 8.132234e-03 2.090 0 0
Cell-extracellular matrix interactions R-HSA-446353 8.132234e-03 2.090 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.709140e-03 2.173 0 0
Smooth Muscle Contraction R-HSA-445355 7.087893e-03 2.149 0 0
PECAM1 interactions R-HSA-210990 6.944190e-03 2.158 0 0
Cytokine Signaling in Immune system R-HSA-1280215 7.369240e-03 2.133 0 0
Hedgehog 'off' state R-HSA-5610787 7.966026e-03 2.099 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 7.662330e-03 2.116 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.161007e-03 2.088 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.167457e-03 2.088 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 8.501464e-03 2.071 0 0
Regulation of signaling by CBL R-HSA-912631 8.556869e-03 2.068 0 0
Translesion Synthesis by POLH R-HSA-110320 8.556869e-03 2.068 0 0
Signaling by SCF-KIT R-HSA-1433557 8.846284e-03 2.053 0 0
Degradation of CDH1 R-HSA-9766229 9.150886e-03 2.039 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.180486e-03 2.037 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 9.180486e-03 2.037 0 0
Synthesis of DNA R-HSA-69239 9.273934e-03 2.033 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.312293e-03 2.031 1 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.461299e-03 2.024 0 0
Integration of provirus R-HSA-162592 9.531454e-03 2.021 0 0
Late endosomal microautophagy R-HSA-9615710 9.843043e-03 2.007 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.843043e-03 2.007 0 0
Reproduction R-HSA-1474165 9.922962e-03 2.003 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.020087e-02 1.991 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.025664e-02 1.989 0 0
Signaling by VEGF R-HSA-194138 1.046145e-02 1.980 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.052113e-02 1.978 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.052113e-02 1.978 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.052113e-02 1.978 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.052113e-02 1.978 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.054802e-02 1.977 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.054802e-02 1.977 0 0
Negative regulation of MET activity R-HSA-6807004 1.072930e-02 1.969 0 0
Gap junction assembly R-HSA-190861 1.080391e-02 1.966 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.091362e-02 1.962 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.140076e-02 1.943 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.150754e-02 1.939 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.177706e-02 1.929 0 0
Activation of the pre-replicative complex R-HSA-68962 1.177706e-02 1.929 0 0
Activation of BH3-only proteins R-HSA-114452 1.177706e-02 1.929 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.183621e-02 1.927 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.183621e-02 1.927 0 0
Interleukin-12 family signaling R-HSA-447115 1.201628e-02 1.920 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.264283e-02 1.898 0 0
Long-term potentiation R-HSA-9620244 1.265001e-02 1.898 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.274115e-02 1.895 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.274115e-02 1.895 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.274115e-02 1.895 0 0
Signaling by NOTCH1 R-HSA-1980143 1.283449e-02 1.892 0 0
Interleukin-12 signaling R-HSA-9020591 1.283449e-02 1.892 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.292337e-02 1.889 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.328472e-02 1.877 0 0
Basigin interactions R-HSA-210991 1.328472e-02 1.877 0 0
FLT3 Signaling R-HSA-9607240 1.328651e-02 1.877 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.341318e-02 1.872 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.344696e-02 1.871 0 0
Orc1 removal from chromatin R-HSA-68949 1.369818e-02 1.863 0 0
EGFR downregulation R-HSA-182971 1.398496e-02 1.854 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.479006e-02 1.830 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.479006e-02 1.830 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.479006e-02 1.830 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.521473e-02 1.818 0 0
Maturation of protein E R-HSA-9683683 1.565888e-02 1.805 0 0
Maturation of protein E R-HSA-9694493 1.565888e-02 1.805 0 0
Regulation of CDH11 function R-HSA-9762292 2.008600e-02 1.697 0 0
2-LTR circle formation R-HSA-164843 2.008600e-02 1.697 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.687638e-02 1.773 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.625847e-02 1.789 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.625847e-02 1.789 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.729461e-02 1.762 0 0
PTEN Regulation R-HSA-6807070 2.142211e-02 1.669 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.145971e-02 1.668 0 0
MTOR signalling R-HSA-165159 1.763044e-02 1.754 0 0
mTORC1-mediated signalling R-HSA-166208 1.968470e-02 1.706 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.088104e-02 1.680 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.129339e-02 1.672 0 0
Signaling by NOTCH3 R-HSA-9012852 1.981898e-02 1.703 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.664106e-02 1.779 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.968470e-02 1.706 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.981898e-02 1.703 0 0
Signaling by NOTCH4 R-HSA-9013694 2.019264e-02 1.695 0 0
Josephin domain DUBs R-HSA-5689877 2.008600e-02 1.697 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.856036e-02 1.731 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.129339e-02 1.672 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.129339e-02 1.672 0 0
Regulation of KIT signaling R-HSA-1433559 2.129339e-02 1.672 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.625847e-02 1.789 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.684861e-02 1.773 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.968470e-02 1.706 0 0
Signaling by KIT in disease R-HSA-9669938 1.968470e-02 1.706 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.205338e-02 1.657 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.205338e-02 1.657 0 0
Ion homeostasis R-HSA-5578775 2.225991e-02 1.652 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.271477e-02 1.644 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.291758e-02 1.640 0 0
Regulation of TP53 Activity R-HSA-5633007 2.323673e-02 1.634 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.377240e-02 1.624 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.377240e-02 1.624 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.377240e-02 1.624 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.377240e-02 1.624 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.377240e-02 1.624 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.377240e-02 1.624 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.377240e-02 1.624 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.377240e-02 1.624 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.377240e-02 1.624 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.377240e-02 1.624 0 0
Signaling by PTK6 R-HSA-8848021 2.413050e-02 1.617 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.413050e-02 1.617 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.517835e-02 1.599 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.519120e-02 1.599 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.519120e-02 1.599 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.550234e-02 1.593 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.559227e-02 1.592 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.573579e-02 1.589 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 2.603403e-02 1.584 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 2.603403e-02 1.584 0 0
Glycolysis R-HSA-70171 2.607342e-02 1.584 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.621086e-02 1.582 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.621086e-02 1.582 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 2.648992e-02 1.577 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.648992e-02 1.577 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.675344e-02 1.573 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.675344e-02 1.573 0 0
Translesion synthesis by REV1 R-HSA-110312 2.675344e-02 1.573 0 0
Protein methylation R-HSA-8876725 2.675344e-02 1.573 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.675344e-02 1.573 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.751643e-02 1.560 0 0
mRNA 3'-end processing R-HSA-72187 2.869094e-02 1.542 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.939557e-02 1.532 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.939557e-02 1.532 0 0
Cellular response to hypoxia R-HSA-1234174 2.969734e-02 1.527 0 0
PCP/CE pathway R-HSA-4086400 2.975834e-02 1.526 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.983315e-02 1.525 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.983315e-02 1.525 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.983315e-02 1.525 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.983315e-02 1.525 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.988012e-02 1.525 0 0
Regulation of Apoptosis R-HSA-169911 2.988012e-02 1.525 0 0
Muscle contraction R-HSA-397014 2.993232e-02 1.524 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.077759e-02 1.512 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.190015e-02 1.496 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.190015e-02 1.496 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.207523e-02 1.494 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.299185e-02 1.482 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.299185e-02 1.482 0 0
Translesion synthesis by POLI R-HSA-5656121 3.306849e-02 1.481 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.306849e-02 1.481 0 0
Trafficking of AMPA receptors R-HSA-399719 3.398999e-02 1.469 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.398999e-02 1.469 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.398999e-02 1.469 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.406544e-02 1.468 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.406544e-02 1.468 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.406544e-02 1.468 0 0
NF-kB is activated and signals survival R-HSA-209560 3.406544e-02 1.468 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.406544e-02 1.468 0 0
G1/S-Specific Transcription R-HSA-69205 3.417025e-02 1.466 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.417025e-02 1.466 0 0
IRE1alpha activates chaperones R-HSA-381070 3.456851e-02 1.461 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 3.499339e-02 1.456 0 0
Signaling by MET R-HSA-6806834 3.564413e-02 1.448 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.581310e-02 1.446 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.609052e-02 1.443 0 0
TCR signaling R-HSA-202403 3.622000e-02 1.441 0 0
RNA Polymerase II Transcription R-HSA-73857 3.659868e-02 1.437 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.667828e-02 1.436 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.667828e-02 1.436 0 0
Co-stimulation by CD28 R-HSA-389356 3.703865e-02 1.431 0 0
Intraflagellar transport R-HSA-5620924 3.703865e-02 1.431 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.794303e-02 1.421 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.794303e-02 1.421 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.812467e-02 1.419 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.852911e-02 1.414 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.872976e-02 1.412 0 0
Degradation of DVL R-HSA-4641258 3.887252e-02 1.410 0 0
Disorders of Developmental Biology R-HSA-9675151 4.027699e-02 1.395 0 0
Translesion synthesis by POLK R-HSA-5655862 4.027699e-02 1.395 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.027699e-02 1.395 0 0
Adrenoceptors R-HSA-390696 4.269200e-02 1.370 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 4.269200e-02 1.370 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.269200e-02 1.370 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.269200e-02 1.370 0 0
Modulation by Mtb of host immune system R-HSA-9637628 4.269200e-02 1.370 0 0
Signaling by FGFR4 R-HSA-5654743 4.282132e-02 1.368 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.285795e-02 1.368 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 4.285795e-02 1.368 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 4.285795e-02 1.368 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 4.341529e-02 1.362 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.341529e-02 1.362 0 0
Assembly Of The HIV Virion R-HSA-175474 4.341529e-02 1.362 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.394278e-02 1.357 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.465561e-02 1.350 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.470577e-02 1.350 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.470577e-02 1.350 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.470577e-02 1.350 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.470577e-02 1.350 0 0
Semaphorin interactions R-HSA-373755 4.601946e-02 1.337 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.601946e-02 1.337 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.954667e-02 1.305 0 0
ALK mutants bind TKIs R-HSA-9700645 5.529424e-02 1.257 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.289434e-02 1.277 0 0
Removal of the Flap Intermediate R-HSA-69166 6.418337e-02 1.193 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.748088e-02 1.240 0 0
Notch-HLH transcription pathway R-HSA-350054 5.082707e-02 1.294 0 0
Deadenylation of mRNA R-HSA-429947 6.791664e-02 1.168 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.874416e-02 1.231 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.874416e-02 1.231 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.082522e-02 1.294 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.465065e-02 1.189 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 6.465065e-02 1.189 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.632327e-02 1.249 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.554283e-02 1.183 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 6.554283e-02 1.183 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.203260e-02 1.207 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.203260e-02 1.207 0 0
Neutrophil degranulation R-HSA-6798695 6.873963e-02 1.163 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.747019e-02 1.241 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.750514e-02 1.171 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.337603e-02 1.273 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.501847e-02 1.259 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.105568e-02 1.292 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.747019e-02 1.241 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.954235e-02 1.305 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.559449e-02 1.255 0 0
G alpha (12/13) signalling events R-HSA-416482 5.315971e-02 1.274 0 0
Signaling by FGFR2 R-HSA-5654738 6.236946e-02 1.205 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.300334e-02 1.201 0 0
Polo-like kinase mediated events R-HSA-156711 5.748088e-02 1.240 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.747019e-02 1.241 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.903230e-02 1.161 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.903230e-02 1.161 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.901742e-02 1.229 0 0
Signaling by FGFR3 R-HSA-5654741 5.337603e-02 1.273 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.791664e-02 1.168 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.207868e-02 1.207 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.811169e-02 1.167 0 0
Death Receptor Signaling R-HSA-73887 5.874788e-02 1.231 0 0
Interleukin-6 signaling R-HSA-1059683 5.289434e-02 1.277 0 0
Developmental Biology R-HSA-1266738 5.854756e-02 1.232 0 0
DAG and IP3 signaling R-HSA-1489509 5.337603e-02 1.273 0 0
Oncogene Induced Senescence R-HSA-2559585 6.465065e-02 1.189 0 0
Glucose metabolism R-HSA-70326 6.664608e-02 1.176 0 0
Signaling by Hedgehog R-HSA-5358351 5.046602e-02 1.297 0 0
HCMV Late Events R-HSA-9610379 6.911390e-02 1.160 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.967985e-02 1.157 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.967985e-02 1.157 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.967985e-02 1.157 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 7.006361e-02 1.155 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 7.006361e-02 1.155 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 7.006361e-02 1.155 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.153010e-02 1.146 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.237375e-02 1.140 0 0
Calmodulin induced events R-HSA-111933 7.237375e-02 1.140 0 0
CaM pathway R-HSA-111997 7.237375e-02 1.140 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.456566e-02 1.127 0 0
Budding and maturation of HIV virion R-HSA-162588 7.535432e-02 1.123 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.535432e-02 1.123 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.609811e-02 1.119 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.617954e-02 1.118 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.646081e-02 1.117 0 0
Ca-dependent events R-HSA-111996 7.646081e-02 1.117 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 7.671647e-02 1.115 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.671647e-02 1.115 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.671647e-02 1.115 0 0
Glycogen synthesis R-HSA-3322077 7.848065e-02 1.105 0 0
Degradation of AXIN R-HSA-4641257 8.064373e-02 1.093 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.064373e-02 1.093 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.139830e-02 1.089 0 0
Signaling by FGFR1 R-HSA-5654736 8.139830e-02 1.089 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 8.165803e-02 1.088 0 0
mRNA Editing: A to I Conversion R-HSA-75064 8.165803e-02 1.088 0 0
Regulation of TP53 Expression R-HSA-6804754 8.165803e-02 1.088 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 8.165803e-02 1.088 0 0
Signalling to ERK5 R-HSA-198765 8.165803e-02 1.088 0 0
C6 deamination of adenosine R-HSA-75102 8.165803e-02 1.088 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 8.165803e-02 1.088 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 8.165803e-02 1.088 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 8.165803e-02 1.088 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 8.165803e-02 1.088 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 8.165803e-02 1.088 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 8.165803e-02 1.088 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 8.165803e-02 1.088 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 8.165803e-02 1.088 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 8.165803e-02 1.088 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.272836e-02 1.082 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.461774e-02 1.073 0 0
DNA strand elongation R-HSA-69190 8.461774e-02 1.073 0 0
ChREBP activates metabolic gene expression R-HSA-163765 8.578831e-02 1.067 0 0
Myogenesis R-HSA-525793 8.806444e-02 1.055 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.806444e-02 1.055 0 0
Adaptive Immune System R-HSA-1280218 8.859453e-02 1.053 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.861207e-02 1.053 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.946192e-02 1.048 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.962281e-02 1.048 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.011207e-02 1.045 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.011207e-02 1.045 0 0
Hedgehog 'on' state R-HSA-5632684 9.011207e-02 1.045 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.039792e-02 1.044 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.039792e-02 1.044 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.039792e-02 1.044 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 9.046891e-02 1.044 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 9.046891e-02 1.044 0 0
Negative regulation of FLT3 R-HSA-9706369 9.046891e-02 1.044 0 0
Regulation of BACH1 activity R-HSA-9708530 9.046891e-02 1.044 0 0
Nef and signal transduction R-HSA-164944 9.176602e-02 1.037 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.451870e-02 1.024 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 9.451870e-02 1.024 0 0
Stabilization of p53 R-HSA-69541 9.882666e-02 1.005 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.882666e-02 1.005 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.882666e-02 1.005 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 9.927663e-02 1.003 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.927663e-02 1.003 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.927663e-02 1.003 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.016175e-01 0.993 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.033085e-01 0.986 0 0
Activation of RAC1 R-HSA-428540 1.035309e-01 0.985 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.035309e-01 0.985 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.041860e-01 0.982 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.050511e-01 0.979 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.050511e-01 0.979 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.054012e-01 0.977 0 0
Infectious disease R-HSA-5663205 1.075701e-01 0.968 0 0
Generic Transcription Pathway R-HSA-212436 1.076362e-01 0.968 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.111883e-01 0.954 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.111883e-01 0.954 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.111883e-01 0.954 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.111883e-01 0.954 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.117993e-01 0.952 0 0
Signaling by ERBB4 R-HSA-1236394 1.117993e-01 0.952 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.121331e-01 0.950 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 1.158643e-01 0.936 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.158643e-01 0.936 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.158643e-01 0.936 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.162051e-01 0.935 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.162051e-01 0.935 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.162051e-01 0.935 0 0
Signaling by NOTCH2 R-HSA-1980145 1.162051e-01 0.935 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.162051e-01 0.935 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.169758e-01 0.932 0 0
FasL/ CD95L signaling R-HSA-75157 1.183801e-01 0.927 0 0
Axonal growth stimulation R-HSA-209563 1.183801e-01 0.927 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.183801e-01 0.927 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.183801e-01 0.927 0 0
MET activates PTPN11 R-HSA-8865999 1.183801e-01 0.927 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.191748e-01 0.924 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.198688e-01 0.921 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.205645e-01 0.919 0 0
PLC beta mediated events R-HSA-112043 1.212797e-01 0.916 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.214609e-01 0.916 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.214609e-01 0.916 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.214609e-01 0.916 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 1.214609e-01 0.916 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.214609e-01 0.916 0 0
Polymerase switching R-HSA-69091 1.227961e-01 0.911 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.227961e-01 0.911 0 0
Leading Strand Synthesis R-HSA-69109 1.227961e-01 0.911 0 0
Regulation of IFNG signaling R-HSA-877312 1.227961e-01 0.911 0 0
Platelet degranulation R-HSA-114608 1.232765e-01 0.909 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.279669e-01 0.893 0 0
PERK regulates gene expression R-HSA-381042 1.279669e-01 0.893 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.301406e-01 0.886 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.301406e-01 0.886 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.301406e-01 0.886 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.315754e-01 0.881 0 0
Interferon alpha/beta signaling R-HSA-909733 1.356078e-01 0.868 0 0
Interleukin-37 signaling R-HSA-9008059 1.372893e-01 0.862 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.385841e-01 0.858 0 0
GAB1 signalosome R-HSA-180292 1.385841e-01 0.858 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.385841e-01 0.858 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 1.385841e-01 0.858 0 0
Mismatch Repair R-HSA-5358508 1.385841e-01 0.858 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.385841e-01 0.858 0 0
RET signaling R-HSA-8853659 1.403193e-01 0.853 0 0
NRAGE signals death through JNK R-HSA-193648 1.410912e-01 0.851 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.100196e-01 0.678 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.100196e-01 0.678 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.100196e-01 0.678 0 0
Defective MOGS causes CDG-2b R-HSA-4793954 2.100196e-01 0.678 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 2.100196e-01 0.678 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.100196e-01 0.678 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.100196e-01 0.678 0 0
Regulation of gap junction activity R-HSA-191650 1.582917e-01 0.801 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.582917e-01 0.801 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.582917e-01 0.801 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.582917e-01 0.801 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.002304e-01 0.698 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.002304e-01 0.698 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.002304e-01 0.698 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.002304e-01 0.698 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.002304e-01 0.698 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.002304e-01 0.698 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.699385e-01 0.770 0 0
Lipophagy R-HSA-9613354 1.699385e-01 0.770 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.699385e-01 0.770 0 0
WNT mediated activation of DVL R-HSA-201688 1.699385e-01 0.770 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.432527e-01 0.614 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.432527e-01 0.614 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.432527e-01 0.614 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.432527e-01 0.614 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.432527e-01 0.614 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.434544e-01 0.843 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.865996e-01 0.543 0 0
HDL clearance R-HSA-8964011 2.865996e-01 0.543 0 0
STAT5 Activation R-HSA-9645135 2.865996e-01 0.543 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.865996e-01 0.543 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.865996e-01 0.543 0 0
p38MAPK events R-HSA-171007 1.883718e-01 0.725 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.566973e-01 0.805 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.566973e-01 0.805 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.566973e-01 0.805 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 1.469960e-01 0.833 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.757193e-01 0.755 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.757193e-01 0.755 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.757193e-01 0.755 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.757193e-01 0.755 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.757193e-01 0.755 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.123236e-01 0.673 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 2.607954e-01 0.584 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 2.607954e-01 0.584 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.370611e-01 0.625 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.370611e-01 0.625 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.976865e-01 0.704 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.976865e-01 0.704 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.624281e-01 0.581 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.624281e-01 0.581 0 0
G-protein beta:gamma signalling R-HSA-397795 1.813207e-01 0.742 0 0
FGFR2 alternative splicing R-HSA-6803529 2.373450e-01 0.625 0 0
Striated Muscle Contraction R-HSA-390522 1.971750e-01 0.705 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.345967e-01 0.630 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.345967e-01 0.630 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.765043e-01 0.753 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.537987e-01 0.596 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.812847e-01 0.551 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.476778e-01 0.606 0 0
RNA Polymerase III Transcription R-HSA-74158 2.476778e-01 0.606 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.537987e-01 0.596 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.537987e-01 0.596 0 0
Lagging Strand Synthesis R-HSA-69186 1.955628e-01 0.709 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.812847e-01 0.551 0 0
Signal amplification R-HSA-392518 2.135495e-01 0.671 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.235430e-01 0.651 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.235430e-01 0.651 0 0
Activation of SMO R-HSA-5635838 2.123236e-01 0.673 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.955628e-01 0.709 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.235430e-01 0.651 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.571253e-01 0.804 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.865996e-01 0.543 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.992459e-01 0.701 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.537987e-01 0.596 0 0
Downstream TCR signaling R-HSA-202424 1.982527e-01 0.703 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.560534e-01 0.592 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.582917e-01 0.801 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.002304e-01 0.698 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.757193e-01 0.755 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.373450e-01 0.625 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.667101e-01 0.778 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.645050e-01 0.784 0 0
GPVI-mediated activation cascade R-HSA-114604 2.476778e-01 0.606 0 0
Ca2+ pathway R-HSA-4086398 1.670483e-01 0.777 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.703770e-01 0.568 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.807525e-01 0.743 0 0
Circadian clock R-HSA-9909396 2.255245e-01 0.647 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.432527e-01 0.614 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.883718e-01 0.725 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.631904e-01 0.787 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.370611e-01 0.625 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.813207e-01 0.742 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.590931e-01 0.587 0 0
Signal transduction by L1 R-HSA-445144 1.757193e-01 0.755 0 0
RMTs methylate histone arginines R-HSA-3214858 1.660438e-01 0.780 0 0
G-protein mediated events R-HSA-112040 1.812752e-01 0.742 0 0
Post-translational protein modification R-HSA-597592 2.601175e-01 0.585 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.434544e-01 0.843 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 2.476778e-01 0.606 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.801062e-01 0.744 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.432527e-01 0.614 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 2.296333e-01 0.639 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.624281e-01 0.581 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.254791e-01 0.647 0 0
Opioid Signalling R-HSA-111885 2.061252e-01 0.686 0 0
Cyclin D associated events in G1 R-HSA-69231 1.660438e-01 0.780 0 0
G1 Phase R-HSA-69236 1.660438e-01 0.780 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.445162e-01 0.612 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.992459e-01 0.701 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.865996e-01 0.543 0 0
TBC/RABGAPs R-HSA-8854214 1.535917e-01 0.814 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.535917e-01 0.814 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.347153e-01 0.629 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.347153e-01 0.629 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.101151e-01 0.678 0 0
Signalling to ERKs R-HSA-187687 2.303993e-01 0.638 0 0
MAP kinase activation R-HSA-450294 1.970969e-01 0.705 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.504079e-01 0.823 0 0
Inhibition of PKR R-HSA-169131 2.100196e-01 0.678 0 0
MTF1 activates gene expression R-HSA-5660489 1.582917e-01 0.801 0 0
Reelin signalling pathway R-HSA-8866376 2.002304e-01 0.698 0 0
ARMS-mediated activation R-HSA-170984 1.699385e-01 0.770 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 1.699385e-01 0.770 0 0
Unwinding of DNA R-HSA-176974 1.699385e-01 0.770 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.432527e-01 0.614 0 0
Protein hydroxylation R-HSA-9629569 1.757193e-01 0.755 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.607954e-01 0.584 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.607954e-01 0.584 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.158710e-01 0.666 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.789545e-01 0.747 0 0
Signaling by FGFR R-HSA-190236 1.529903e-01 0.815 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.784690e-01 0.555 0 0
Signaling by Leptin R-HSA-2586552 1.992459e-01 0.701 0 0
Hemostasis R-HSA-109582 2.095154e-01 0.679 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.370611e-01 0.625 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.970969e-01 0.705 0 0
Signal regulatory protein family interactions R-HSA-391160 1.653633e-01 0.782 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 1.757193e-01 0.755 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.646964e-01 0.577 0 0
Interleukin-1 signaling R-HSA-9020702 1.785532e-01 0.748 0 0
Netrin-1 signaling R-HSA-373752 1.660438e-01 0.780 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.801062e-01 0.744 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.992459e-01 0.701 0 0
Signaling by NTRKs R-HSA-166520 2.458370e-01 0.609 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.955628e-01 0.709 0 0
Ion transport by P-type ATPases R-HSA-936837 2.347611e-01 0.629 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.699385e-01 0.770 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.432527e-01 0.614 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.865996e-01 0.543 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.345967e-01 0.630 0 0
Diseases of DNA repair R-HSA-9675135 1.923016e-01 0.716 0 0
Zinc transporters R-HSA-435354 1.653633e-01 0.782 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.434544e-01 0.843 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.161362e-01 0.665 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.737714e-01 0.563 0 0
Neurodegenerative Diseases R-HSA-8863678 1.469960e-01 0.833 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.469960e-01 0.833 0 0
Iron uptake and transport R-HSA-917937 2.784690e-01 0.555 0 0
Interleukin-1 family signaling R-HSA-446652 2.139463e-01 0.670 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.646964e-01 0.577 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.801112e-01 0.553 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.151061e-01 0.667 0 0
Interleukin-6 family signaling R-HSA-6783589 2.812847e-01 0.551 0 0
NrCAM interactions R-HSA-447038 2.002304e-01 0.698 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.653633e-01 0.782 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.161362e-01 0.665 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.161362e-01 0.665 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.101151e-01 0.678 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.566973e-01 0.805 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.432527e-01 0.614 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.883718e-01 0.725 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.370611e-01 0.625 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.573440e-01 0.589 0 0
Translation of Structural Proteins R-HSA-9683701 2.254791e-01 0.647 0 0
Glycogen storage diseases R-HSA-3229121 2.624281e-01 0.581 0 0
Platelet sensitization by LDL R-HSA-432142 2.882719e-01 0.540 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.882719e-01 0.540 0 0
Nephron development R-HSA-9831926 2.882719e-01 0.540 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.904782e-01 0.537 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.904782e-01 0.537 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.924484e-01 0.534 0 0
Pervasive developmental disorders R-HSA-9005895 2.924484e-01 0.534 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.924484e-01 0.534 0 0
Disorders of Nervous System Development R-HSA-9697154 2.924484e-01 0.534 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.924484e-01 0.534 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.924484e-01 0.534 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.924484e-01 0.534 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 2.978664e-01 0.526 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.978664e-01 0.526 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.978664e-01 0.526 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.978664e-01 0.526 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.978664e-01 0.526 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.978664e-01 0.526 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.978664e-01 0.526 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.978664e-01 0.526 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.978664e-01 0.526 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.978664e-01 0.526 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 2.978664e-01 0.526 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.978664e-01 0.526 0 0
Inositol phosphate metabolism R-HSA-1483249 2.989776e-01 0.524 0 0
Metabolism of proteins R-HSA-392499 3.001800e-01 0.523 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.016017e-01 0.521 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.038246e-01 0.517 0 0
TGFBR3 expression R-HSA-9839394 3.038246e-01 0.517 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.038246e-01 0.517 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.089925e-01 0.510 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.089925e-01 0.510 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.089925e-01 0.510 0 0
Nuclear RNA decay R-HSA-9930044 3.136011e-01 0.504 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.136011e-01 0.504 0 0
Rap1 signalling R-HSA-392517 3.144455e-01 0.502 0 0
The NLRP3 inflammasome R-HSA-844456 3.144455e-01 0.502 0 0
Maturation of nucleoprotein R-HSA-9694631 3.144455e-01 0.502 0 0
Mitochondrial protein import R-HSA-1268020 3.147116e-01 0.502 0 0
Interleukin-17 signaling R-HSA-448424 3.169584e-01 0.499 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.169584e-01 0.499 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.197278e-01 0.495 0 0
Generation of second messenger molecules R-HSA-202433 3.201083e-01 0.495 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.201083e-01 0.495 0 0
Glycogen metabolism R-HSA-8982491 3.201083e-01 0.495 0 0
Formation of axial mesoderm R-HSA-9796292 3.243326e-01 0.489 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.243326e-01 0.489 0 0
Processing of SMDT1 R-HSA-8949664 3.243326e-01 0.489 0 0
Frs2-mediated activation R-HSA-170968 3.243326e-01 0.489 0 0
Maturation of nucleoprotein R-HSA-9683610 3.243326e-01 0.489 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.245762e-01 0.489 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.296674e-01 0.482 0 0
SOS-mediated signalling R-HSA-112412 3.296674e-01 0.482 0 0
Recycling of eIF2:GDP R-HSA-72731 3.296674e-01 0.482 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.296674e-01 0.482 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.296674e-01 0.482 0 0
Netrin mediated repulsion signals R-HSA-418886 3.296674e-01 0.482 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.296674e-01 0.482 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.313064e-01 0.480 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.314416e-01 0.480 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.387990e-01 0.470 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.390714e-01 0.470 0 0
Signaling by Interleukins R-HSA-449147 3.416594e-01 0.466 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.446288e-01 0.463 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.457193e-01 0.461 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.495807e-01 0.456 0 0
Signaling by BMP R-HSA-201451 3.495807e-01 0.456 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.495807e-01 0.456 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 3.495807e-01 0.456 0 0
Retrograde neurotrophin signalling R-HSA-177504 3.562140e-01 0.448 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.562140e-01 0.448 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.562140e-01 0.448 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.564797e-01 0.448 0 0
Intra-Golgi traffic R-HSA-6811438 3.576251e-01 0.447 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.621964e-01 0.441 0 0
ERK/MAPK targets R-HSA-198753 3.672321e-01 0.435 0 0
Signalling to RAS R-HSA-167044 3.672321e-01 0.435 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.672321e-01 0.435 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.672321e-01 0.435 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.719824e-01 0.429 0 0
Type I hemidesmosome assembly R-HSA-446107 3.719824e-01 0.429 0 0
RSK activation R-HSA-444257 3.719824e-01 0.429 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.719824e-01 0.429 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.719824e-01 0.429 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.719824e-01 0.429 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.719824e-01 0.429 0 0
Interleukin-9 signaling R-HSA-8985947 3.719824e-01 0.429 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.719824e-01 0.429 0 0
HIV elongation arrest and recovery R-HSA-167287 3.726204e-01 0.429 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.726204e-01 0.429 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 3.726204e-01 0.429 0 0
ER-Phagosome pathway R-HSA-1236974 3.726613e-01 0.429 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.759492e-01 0.425 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.759492e-01 0.425 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.759492e-01 0.425 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.759492e-01 0.425 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 3.759492e-01 0.425 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 3.759492e-01 0.425 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.759492e-01 0.425 0 0
Defective ABCB6 causes MCOPCB7 R-HSA-5683371 3.759492e-01 0.425 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.759492e-01 0.425 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.759492e-01 0.425 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 3.759492e-01 0.425 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.759492e-01 0.425 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.759492e-01 0.425 0 0
Cellular response to chemical stress R-HSA-9711123 3.840119e-01 0.416 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.842059e-01 0.415 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.878845e-01 0.411 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.878845e-01 0.411 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 3.878845e-01 0.411 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 3.878845e-01 0.411 0 0
Regulation of beta-cell development R-HSA-186712 3.930535e-01 0.406 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.935916e-01 0.405 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.956569e-01 0.403 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.018136e-01 0.396 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.018136e-01 0.396 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.018136e-01 0.396 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.045035e-01 0.393 0 0
Transcription of the HIV genome R-HSA-167172 4.070229e-01 0.390 0 0
Regulated Necrosis R-HSA-5218859 4.070229e-01 0.390 0 0
RAB geranylgeranylation R-HSA-8873719 4.095373e-01 0.388 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 4.131797e-01 0.384 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.131797e-01 0.384 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 4.131797e-01 0.384 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.131797e-01 0.384 0 0
mRNA Editing R-HSA-75072 4.131797e-01 0.384 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.131797e-01 0.384 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.131797e-01 0.384 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.131797e-01 0.384 0 0
Interleukin-21 signaling R-HSA-9020958 4.131797e-01 0.384 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.131797e-01 0.384 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.131797e-01 0.384 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 4.131797e-01 0.384 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.161308e-01 0.381 0 0
DAP12 signaling R-HSA-2424491 4.186126e-01 0.378 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.186126e-01 0.378 0 0
Phosphorylation of the APC/C R-HSA-176412 4.191614e-01 0.378 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 4.191614e-01 0.378 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.191614e-01 0.378 0 0
Prolonged ERK activation events R-HSA-169893 4.191614e-01 0.378 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 4.191614e-01 0.378 0 0
FOXO-mediated transcription R-HSA-9614085 4.231255e-01 0.374 0 0
Formation of paraxial mesoderm R-HSA-9793380 4.260184e-01 0.371 0 0
ABC transporter disorders R-HSA-5619084 4.340775e-01 0.362 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.370070e-01 0.360 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.370070e-01 0.360 0 0
COPII-mediated vesicle transport R-HSA-204005 4.381393e-01 0.358 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.408442e-01 0.356 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.414152e-01 0.355 0 0
Downstream signal transduction R-HSA-186763 4.414152e-01 0.355 0 0
MET activates STAT3 R-HSA-8875791 4.453526e-01 0.351 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.453526e-01 0.351 0 0
Signalling to STAT3 R-HSA-198745 4.453526e-01 0.351 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.453526e-01 0.351 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.453526e-01 0.351 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.453526e-01 0.351 0 0
MET interacts with TNS proteins R-HSA-8875513 4.453526e-01 0.351 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.453526e-01 0.351 0 0
Intracellular oxygen transport R-HSA-8981607 4.453526e-01 0.351 0 0
Histamine receptors R-HSA-390650 4.453526e-01 0.351 0 0
Growth hormone receptor signaling R-HSA-982772 4.456824e-01 0.351 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.487482e-01 0.348 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 4.498873e-01 0.347 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.498873e-01 0.347 0 0
Signaling by TGFBR3 R-HSA-9839373 4.521766e-01 0.345 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.521766e-01 0.345 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.529847e-01 0.344 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.529847e-01 0.344 0 0
PI3K/AKT activation R-HSA-198203 4.529847e-01 0.344 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.529847e-01 0.344 0 0
DNA replication initiation R-HSA-68952 4.529847e-01 0.344 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.529847e-01 0.344 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.529847e-01 0.344 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.529847e-01 0.344 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.529847e-01 0.344 0 0
Interleukin-27 signaling R-HSA-9020956 4.529847e-01 0.344 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.529847e-01 0.344 0 0
Pyruvate metabolism R-HSA-70268 4.584123e-01 0.339 0 0
G alpha (z) signalling events R-HSA-418597 4.645560e-01 0.333 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.698893e-01 0.328 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.698893e-01 0.328 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.780103e-01 0.321 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.799280e-01 0.319 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.799280e-01 0.319 0 0
TNF signaling R-HSA-75893 4.818731e-01 0.317 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.818731e-01 0.317 0 0
Ion channel transport R-HSA-983712 4.880813e-01 0.312 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.894034e-01 0.310 0 0
Gluconeogenesis R-HSA-70263 4.894034e-01 0.310 0 0
Metal ion SLC transporters R-HSA-425410 4.894034e-01 0.310 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.910721e-01 0.309 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.911977e-01 0.309 0 0
Signaling by APC mutants R-HSA-4839744 4.911977e-01 0.309 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.911977e-01 0.309 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.911977e-01 0.309 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.911977e-01 0.309 0 0
Bicarbonate transporters R-HSA-425381 4.911977e-01 0.309 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.911977e-01 0.309 0 0
vRNP Assembly R-HSA-192905 4.911977e-01 0.309 0 0
Suppression of apoptosis R-HSA-9635465 4.911977e-01 0.309 0 0
Interleukin-2 signaling R-HSA-9020558 4.911977e-01 0.309 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.963062e-01 0.304 0 0
Tight junction interactions R-HSA-420029 4.963062e-01 0.304 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.070410e-01 0.295 0 0
HCN channels R-HSA-1296061 5.070410e-01 0.295 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.070410e-01 0.295 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.070410e-01 0.295 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.070410e-01 0.295 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 5.070410e-01 0.295 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 5.070410e-01 0.295 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.070410e-01 0.295 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.070410e-01 0.295 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.070410e-01 0.295 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.070410e-01 0.295 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.070410e-01 0.295 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.070410e-01 0.295 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.070410e-01 0.295 0 0
NADE modulates death signalling R-HSA-205025 5.070410e-01 0.295 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 5.077385e-01 0.294 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.082613e-01 0.294 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.091717e-01 0.293 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.134852e-01 0.289 0 0
Interferon gamma signaling R-HSA-877300 5.174660e-01 0.286 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.178087e-01 0.286 0 0
Suppression of phagosomal maturation R-HSA-9637687 5.208702e-01 0.283 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.276804e-01 0.278 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.276804e-01 0.278 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.276804e-01 0.278 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.276804e-01 0.278 0 0
Signaling by AXIN mutants R-HSA-4839735 5.276804e-01 0.278 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.276804e-01 0.278 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.298360e-01 0.276 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.298360e-01 0.276 0 0
Extension of Telomeres R-HSA-180786 5.328413e-01 0.273 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.372621e-01 0.270 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.375268e-01 0.270 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 5.375268e-01 0.270 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.375268e-01 0.270 0 0
Translation of Structural Proteins R-HSA-9694635 5.447356e-01 0.264 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 5.448497e-01 0.264 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.448497e-01 0.264 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.448497e-01 0.264 0 0
Cristae formation R-HSA-8949613 5.448497e-01 0.264 0 0
Maturation of hRSV A proteins R-HSA-9828806 5.448497e-01 0.264 0 0
ABC-family proteins mediated transport R-HSA-382556 5.464164e-01 0.262 0 0
Transmission across Chemical Synapses R-HSA-112315 5.487720e-01 0.261 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.592682e-01 0.252 0 0
Neurexins and neuroligins R-HSA-6794361 5.612523e-01 0.251 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.612523e-01 0.251 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.618715e-01 0.250 0 0
IRS activation R-HSA-74713 5.618715e-01 0.250 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.618715e-01 0.250 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.618715e-01 0.250 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.618715e-01 0.250 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.618715e-01 0.250 0 0
PTK6 Activates STAT3 R-HSA-8849474 5.618715e-01 0.250 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.618715e-01 0.250 0 0
PTK6 Down-Regulation R-HSA-8849472 5.618715e-01 0.250 0 0
Activation of AKT2 R-HSA-165158 5.618715e-01 0.250 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.618715e-01 0.250 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.618715e-01 0.250 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.618715e-01 0.250 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.618715e-01 0.250 0 0
Inositol transporters R-HSA-429593 5.618715e-01 0.250 0 0
Co-inhibition by BTLA R-HSA-9927353 5.618715e-01 0.250 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.618715e-01 0.250 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.618715e-01 0.250 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.618715e-01 0.250 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.621451e-01 0.250 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.623451e-01 0.250 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.623451e-01 0.250 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.623451e-01 0.250 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.623451e-01 0.250 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.623451e-01 0.250 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.623451e-01 0.250 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.623451e-01 0.250 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.623451e-01 0.250 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.623451e-01 0.250 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.623451e-01 0.250 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.623451e-01 0.250 0 0
Interleukin-35 Signalling R-HSA-8984722 5.623451e-01 0.250 0 0
Interleukin-15 signaling R-HSA-8983432 5.623451e-01 0.250 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.623451e-01 0.250 0 0
Immune System R-HSA-168256 5.624826e-01 0.250 0 0
Formation of definitive endoderm R-HSA-9823730 5.649207e-01 0.248 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.649207e-01 0.248 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.681920e-01 0.246 0 0
Inflammasomes R-HSA-622312 5.681920e-01 0.246 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.681920e-01 0.246 0 0
RUNX2 regulates bone development R-HSA-8941326 5.716464e-01 0.243 0 0
Amine ligand-binding receptors R-HSA-375280 5.751055e-01 0.240 0 0
Mitochondrial biogenesis R-HSA-1592230 5.793058e-01 0.237 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.818112e-01 0.235 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.818112e-01 0.235 0 0
G-protein activation R-HSA-202040 5.912976e-01 0.228 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.934374e-01 0.227 0 0
Somitogenesis R-HSA-9824272 5.934374e-01 0.227 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.951449e-01 0.225 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.951449e-01 0.225 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.951449e-01 0.225 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.951449e-01 0.225 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.951449e-01 0.225 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.951449e-01 0.225 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.951449e-01 0.225 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.970845e-01 0.224 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 5.998642e-01 0.222 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.021876e-01 0.220 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.106062e-01 0.214 0 0
Plus-strand DNA synthesis R-HSA-164525 6.106062e-01 0.214 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.106062e-01 0.214 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.106062e-01 0.214 0 0
Phosphorylation of Emi1 R-HSA-176417 6.106062e-01 0.214 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.106062e-01 0.214 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.106062e-01 0.214 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.106062e-01 0.214 0 0
Signaling by MST1 R-HSA-8852405 6.106062e-01 0.214 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 6.106062e-01 0.214 0 0
TRAIL signaling R-HSA-75158 6.106062e-01 0.214 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.106062e-01 0.214 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.106062e-01 0.214 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.113429e-01 0.214 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.113429e-01 0.214 0 0
MET promotes cell motility R-HSA-8875878 6.114339e-01 0.214 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 6.114339e-01 0.214 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 6.127978e-01 0.213 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.127978e-01 0.213 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.166170e-01 0.210 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.260658e-01 0.203 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.260658e-01 0.203 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.260658e-01 0.203 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 6.260658e-01 0.203 0 0
Prolactin receptor signaling R-HSA-1170546 6.260658e-01 0.203 0 0
Malate-aspartate shuttle R-HSA-9856872 6.260658e-01 0.203 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.260658e-01 0.203 0 0
Signaling by FGFR in disease R-HSA-1226099 6.287409e-01 0.202 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.288014e-01 0.201 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.304989e-01 0.200 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.304989e-01 0.200 0 0
RAS processing R-HSA-9648002 6.304989e-01 0.200 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.318233e-01 0.199 0 0
tRNA processing R-HSA-72306 6.362419e-01 0.196 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.408519e-01 0.193 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.408519e-01 0.193 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.408519e-01 0.193 0 0
LDL clearance R-HSA-8964038 6.408519e-01 0.193 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.489833e-01 0.188 0 0
HIV Transcription Elongation R-HSA-167169 6.489833e-01 0.188 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.489833e-01 0.188 0 0
Interleukin-2 family signaling R-HSA-451927 6.489833e-01 0.188 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.539225e-01 0.184 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.539225e-01 0.184 0 0
Uncoating of the HIV Virion R-HSA-162585 6.539225e-01 0.184 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.539225e-01 0.184 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.539225e-01 0.184 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.539225e-01 0.184 0 0
Abacavir transmembrane transport R-HSA-2161517 6.539225e-01 0.184 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 6.539225e-01 0.184 0 0
CREB phosphorylation R-HSA-199920 6.539225e-01 0.184 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.539225e-01 0.184 0 0
MET Receptor Activation R-HSA-6806942 6.539225e-01 0.184 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.544313e-01 0.184 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.551198e-01 0.184 0 0
Erythropoietin activates RAS R-HSA-9027284 6.551198e-01 0.184 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.551198e-01 0.184 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.551198e-01 0.184 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.551198e-01 0.184 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.551198e-01 0.184 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.551198e-01 0.184 0 0
Biotin transport and metabolism R-HSA-196780 6.551198e-01 0.184 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 6.557814e-01 0.183 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.563343e-01 0.183 0 0
Cardiac conduction R-HSA-5576891 6.584611e-01 0.181 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.639872e-01 0.178 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.639872e-01 0.178 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.639872e-01 0.178 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.639872e-01 0.178 0 0
Interleukin-20 family signaling R-HSA-8854691 6.639872e-01 0.178 0 0
Syndecan interactions R-HSA-3000170 6.639872e-01 0.178 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 6.639872e-01 0.178 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.716892e-01 0.173 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.726157e-01 0.172 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.740849e-01 0.171 0 0
Gastrulation R-HSA-9758941 6.794958e-01 0.168 0 0
Killing mechanisms R-HSA-9664420 6.823397e-01 0.166 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.823397e-01 0.166 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.823397e-01 0.166 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.823397e-01 0.166 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.829646e-01 0.166 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.841522e-01 0.165 0 0
HIV Transcription Initiation R-HSA-167161 6.841522e-01 0.165 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.841522e-01 0.165 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 6.860184e-01 0.164 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.860184e-01 0.164 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.860184e-01 0.164 0 0
Potential therapeutics for SARS R-HSA-9679191 6.888241e-01 0.162 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.889615e-01 0.162 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.924226e-01 0.160 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.924226e-01 0.160 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.924226e-01 0.160 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.924226e-01 0.160 0 0
DAG1 core M1 glycosylations R-HSA-8932506 6.924226e-01 0.160 0 0
Disinhibition of SNARE formation R-HSA-114516 6.924226e-01 0.160 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.924226e-01 0.160 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.924226e-01 0.160 0 0
Mitochondrial ABC transporters R-HSA-1369007 6.924226e-01 0.160 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.924226e-01 0.160 0 0
VLDL clearance R-HSA-8964046 6.924226e-01 0.160 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.924226e-01 0.160 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.924226e-01 0.160 0 0
CHL1 interactions R-HSA-447041 6.924226e-01 0.160 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.924226e-01 0.160 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.924226e-01 0.160 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.928174e-01 0.159 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.929497e-01 0.159 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.929497e-01 0.159 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.008172e-01 0.154 0 0
Aquaporin-mediated transport R-HSA-445717 7.031122e-01 0.153 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.069498e-01 0.151 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.077738e-01 0.150 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.077738e-01 0.150 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.077738e-01 0.150 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 7.077738e-01 0.150 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.077738e-01 0.150 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 7.077738e-01 0.150 0 0
Galactose catabolism R-HSA-70370 7.077738e-01 0.150 0 0
Coenzyme A biosynthesis R-HSA-196783 7.077738e-01 0.150 0 0
Passive transport by Aquaporins R-HSA-432047 7.077738e-01 0.150 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 7.077738e-01 0.150 0 0
Response to metal ions R-HSA-5660526 7.077738e-01 0.150 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.110223e-01 0.148 0 0
Protein localization R-HSA-9609507 7.158662e-01 0.145 0 0
Heme signaling R-HSA-9707616 7.168313e-01 0.145 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.168623e-01 0.145 0 0
Amino acids regulate mTORC1 R-HSA-9639288 7.233794e-01 0.141 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.266416e-01 0.139 0 0
Minus-strand DNA synthesis R-HSA-164516 7.266416e-01 0.139 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.266416e-01 0.139 0 0
phospho-PLA2 pathway R-HSA-111995 7.266416e-01 0.139 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.266416e-01 0.139 0 0
DAG1 core M2 glycosylations R-HSA-8932504 7.266416e-01 0.139 0 0
MET receptor recycling R-HSA-8875656 7.266416e-01 0.139 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.266416e-01 0.139 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.266416e-01 0.139 0 0
Interleukin-23 signaling R-HSA-9020933 7.266416e-01 0.139 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.266416e-01 0.139 0 0
Regulation by c-FLIP R-HSA-3371378 7.266416e-01 0.139 0 0
Fructose biosynthesis R-HSA-5652227 7.266416e-01 0.139 0 0
Activation of RAS in B cells R-HSA-1169092 7.266416e-01 0.139 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.266416e-01 0.139 0 0
Dimerization of procaspase-8 R-HSA-69416 7.266416e-01 0.139 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.266416e-01 0.139 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.266416e-01 0.139 0 0
Sodium/Proton exchangers R-HSA-425986 7.266416e-01 0.139 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.266416e-01 0.139 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.267933e-01 0.139 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 7.267933e-01 0.139 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.267933e-01 0.139 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.267933e-01 0.139 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.283044e-01 0.138 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.314827e-01 0.136 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.314827e-01 0.136 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.314827e-01 0.136 0 0
DAP12 interactions R-HSA-2172127 7.322861e-01 0.135 0 0
Triglyceride catabolism R-HSA-163560 7.448014e-01 0.128 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.455675e-01 0.128 0 0
Insulin processing R-HSA-264876 7.455675e-01 0.128 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.470903e-01 0.127 0 0
Stimuli-sensing channels R-HSA-2672351 7.528770e-01 0.123 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.535352e-01 0.123 0 0
PKA activation in glucagon signalling R-HSA-164378 7.535352e-01 0.123 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.535352e-01 0.123 0 0
PKA activation R-HSA-163615 7.535352e-01 0.123 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.535352e-01 0.123 0 0
Apoptotic factor-mediated response R-HSA-111471 7.535352e-01 0.123 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.535352e-01 0.123 0 0
Tie2 Signaling R-HSA-210993 7.535352e-01 0.123 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.535352e-01 0.123 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.535352e-01 0.123 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 7.570555e-01 0.121 0 0
CASP8 activity is inhibited R-HSA-5218900 7.570555e-01 0.121 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.570555e-01 0.121 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.570555e-01 0.121 0 0
Calcineurin activates NFAT R-HSA-2025928 7.570555e-01 0.121 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.570555e-01 0.121 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.570555e-01 0.121 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.570555e-01 0.121 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.570555e-01 0.121 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.570555e-01 0.121 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.570555e-01 0.121 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.612790e-01 0.118 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.612790e-01 0.118 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.632962e-01 0.117 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.632962e-01 0.117 0 0
Insulin receptor recycling R-HSA-77387 7.632962e-01 0.117 0 0
Neddylation R-HSA-8951664 7.656477e-01 0.116 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.740065e-01 0.111 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.740065e-01 0.111 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.740065e-01 0.111 0 0
Other interleukin signaling R-HSA-449836 7.740065e-01 0.111 0 0
Crosslinking of collagen fibrils R-HSA-2243919 7.740065e-01 0.111 0 0
Synthesis of PC R-HSA-1483191 7.748588e-01 0.111 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.754815e-01 0.110 0 0
Elastic fibre formation R-HSA-1566948 7.754815e-01 0.110 0 0
IRS-mediated signalling R-HSA-112399 7.762910e-01 0.110 0 0
SLC-mediated transport of amino acids R-HSA-9958863 7.788870e-01 0.109 0 0
Signaling by Erythropoietin R-HSA-9006335 7.800077e-01 0.108 0 0
mRNA Capping R-HSA-72086 7.800077e-01 0.108 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.800077e-01 0.108 0 0
Platelet calcium homeostasis R-HSA-418360 7.800077e-01 0.108 0 0
DARPP-32 events R-HSA-180024 7.800077e-01 0.108 0 0
Glucagon-type ligand receptors R-HSA-420092 7.800077e-01 0.108 0 0
Binding and entry of HIV virion R-HSA-173107 7.840870e-01 0.106 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.840870e-01 0.106 0 0
Metabolism of serotonin R-HSA-380612 7.840870e-01 0.106 0 0
Signal attenuation R-HSA-74749 7.840870e-01 0.106 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.840870e-01 0.106 0 0
Maturation of spike protein R-HSA-9683686 7.840870e-01 0.106 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.840870e-01 0.106 0 0
Sperm Motility And Taxes R-HSA-1300642 7.840870e-01 0.106 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.840870e-01 0.106 0 0
Formation of apoptosome R-HSA-111458 7.840870e-01 0.106 0 0
GPER1 signaling R-HSA-9634597 7.878381e-01 0.104 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.896925e-01 0.103 0 0
Signaling by ALK R-HSA-201556 7.896925e-01 0.103 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.896925e-01 0.103 0 0
Neuronal System R-HSA-112316 7.922474e-01 0.101 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.929752e-01 0.101 0 0
Signaling by NODAL R-HSA-1181150 7.929752e-01 0.101 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.929752e-01 0.101 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.957338e-01 0.099 0 0
Disease R-HSA-1643685 7.975730e-01 0.098 0 0
Peroxisomal protein import R-HSA-9033241 7.997237e-01 0.097 0 0
Amino acid transport across the plasma membrane R-HSA-352230 7.997237e-01 0.097 0 0
RSV-host interactions R-HSA-9833110 8.025469e-01 0.096 0 0
Sensory processing of sound R-HSA-9659379 8.025574e-01 0.096 0 0
Toll-like Receptor Cascades R-HSA-168898 8.030064e-01 0.095 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.081123e-01 0.093 0 0
Chylomicron assembly R-HSA-8963888 8.081123e-01 0.093 0 0
vRNA Synthesis R-HSA-192814 8.081123e-01 0.093 0 0
Conjugation of benzoate with glycine R-HSA-177135 8.081123e-01 0.093 0 0
Propionyl-CoA catabolism R-HSA-71032 8.081123e-01 0.093 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.081123e-01 0.093 0 0
Synthesis of PI R-HSA-1483226 8.081123e-01 0.093 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.081123e-01 0.093 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.081123e-01 0.093 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.081123e-01 0.093 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.081123e-01 0.093 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.105223e-01 0.091 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 8.105223e-01 0.091 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.105223e-01 0.091 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.105223e-01 0.091 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.105223e-01 0.091 0 0
PI3K Cascade R-HSA-109704 8.120384e-01 0.090 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.128045e-01 0.090 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.142353e-01 0.089 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.212112e-01 0.086 0 0
Signaling by WNT in cancer R-HSA-4791275 8.243697e-01 0.084 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.244306e-01 0.084 0 0
Leishmania phagocytosis R-HSA-9664417 8.244306e-01 0.084 0 0
Parasite infection R-HSA-9664407 8.244306e-01 0.084 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.267292e-01 0.083 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.267292e-01 0.083 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.267292e-01 0.083 0 0
Ribavirin ADME R-HSA-9755088 8.267292e-01 0.083 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.280264e-01 0.082 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.294655e-01 0.081 0 0
ERKs are inactivated R-HSA-202670 8.294655e-01 0.081 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.294655e-01 0.081 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.294655e-01 0.081 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.294655e-01 0.081 0 0
Plasmalogen biosynthesis R-HSA-75896 8.294655e-01 0.081 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.294655e-01 0.081 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.294655e-01 0.081 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.294655e-01 0.081 0 0
Sodium/Calcium exchangers R-HSA-425561 8.294655e-01 0.081 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.294655e-01 0.081 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.302463e-01 0.081 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.389555e-01 0.076 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.394419e-01 0.076 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.416768e-01 0.075 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.416768e-01 0.075 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 8.416768e-01 0.075 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.416768e-01 0.075 0 0
Signaling by Insulin receptor R-HSA-74752 8.472620e-01 0.072 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 8.472620e-01 0.072 0 0
Conjugation of salicylate with glycine R-HSA-177128 8.484436e-01 0.071 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.484436e-01 0.071 0 0
MET activates RAS signaling R-HSA-8851805 8.484436e-01 0.071 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.484436e-01 0.071 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.484436e-01 0.071 0 0
OAS antiviral response R-HSA-8983711 8.484436e-01 0.071 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.495011e-01 0.071 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.495011e-01 0.071 0 0
IGF1R signaling cascade R-HSA-2428924 8.499649e-01 0.071 0 0
Insulin receptor signalling cascade R-HSA-74751 8.499649e-01 0.071 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.526397e-01 0.069 0 0
PI Metabolism R-HSA-1483255 8.551411e-01 0.068 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.562347e-01 0.067 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.586672e-01 0.066 0 0
Proteasome assembly R-HSA-9907900 8.603680e-01 0.065 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.653107e-01 0.063 0 0
Chylomicron remodeling R-HSA-8963901 8.653107e-01 0.063 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.653107e-01 0.063 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.653107e-01 0.063 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.653107e-01 0.063 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.681102e-01 0.061 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.689193e-01 0.061 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.698429e-01 0.061 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.699275e-01 0.061 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.714403e-01 0.060 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.716938e-01 0.060 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.789178e-01 0.056 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.797480e-01 0.056 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.797480e-01 0.056 0 0
G protein gated Potassium channels R-HSA-1296059 8.797480e-01 0.056 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.797480e-01 0.056 0 0
Formation of the nephric duct R-HSA-9830364 8.797480e-01 0.056 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.797480e-01 0.056 0 0
HDMs demethylate histones R-HSA-3214842 8.797480e-01 0.056 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.797480e-01 0.056 0 0
Interleukin-7 signaling R-HSA-1266695 8.797480e-01 0.056 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.797480e-01 0.056 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.797947e-01 0.056 0 0
HDL assembly R-HSA-8963896 8.803015e-01 0.055 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.803015e-01 0.055 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.803015e-01 0.055 0 0
Hydrolysis of LPC R-HSA-1483115 8.803015e-01 0.055 0 0
cGMP effects R-HSA-418457 8.803015e-01 0.055 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.803015e-01 0.055 0 0
Ciprofloxacin ADME R-HSA-9793528 8.803015e-01 0.055 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.803015e-01 0.055 0 0
P2Y receptors R-HSA-417957 8.803015e-01 0.055 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.803015e-01 0.055 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.813110e-01 0.055 0 0
Platelet homeostasis R-HSA-418346 8.870648e-01 0.052 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.875022e-01 0.052 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.876363e-01 0.052 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.894025e-01 0.051 0 0
MET activates PTK2 signaling R-HSA-8874081 8.904301e-01 0.050 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.904301e-01 0.050 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.904301e-01 0.050 0 0
Urea cycle R-HSA-70635 8.904301e-01 0.050 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.936246e-01 0.049 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.936246e-01 0.049 0 0
Protein lipoylation R-HSA-9857492 8.936246e-01 0.049 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.936246e-01 0.049 0 0
Signaling by Activin R-HSA-1502540 8.936246e-01 0.049 0 0
Transport and metabolism of PAPS R-HSA-174362 8.936246e-01 0.049 0 0
DNA Damage Reversal R-HSA-73942 8.936246e-01 0.049 0 0
Protein repair R-HSA-5676934 8.936246e-01 0.049 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.936246e-01 0.049 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.990477e-01 0.046 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.002249e-01 0.046 0 0
tRNA Aminoacylation R-HSA-379724 9.016998e-01 0.045 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.054654e-01 0.043 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.054654e-01 0.043 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.054654e-01 0.043 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.054654e-01 0.043 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 9.054654e-01 0.043 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.054654e-01 0.043 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.054654e-01 0.043 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.054654e-01 0.043 0 0
Differentiation of T cells R-HSA-9945266 9.054654e-01 0.043 0 0
Carnitine synthesis R-HSA-71262 9.054654e-01 0.043 0 0
Attachment and Entry R-HSA-9678110 9.054654e-01 0.043 0 0
Pentose phosphate pathway R-HSA-71336 9.069885e-01 0.042 0 0
Telomere Extension By Telomerase R-HSA-171319 9.091976e-01 0.041 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.091976e-01 0.041 0 0
Integration of energy metabolism R-HSA-163685 9.106019e-01 0.041 0 0
Signaling by PDGF R-HSA-186797 9.143120e-01 0.039 0 0
Diseases of Immune System R-HSA-5260271 9.143590e-01 0.039 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.143590e-01 0.039 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.143590e-01 0.039 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.143590e-01 0.039 0 0
Glycine degradation R-HSA-6783984 9.159889e-01 0.038 0 0
Scavenging by Class B Receptors R-HSA-3000471 9.159889e-01 0.038 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.159889e-01 0.038 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.159889e-01 0.038 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.159889e-01 0.038 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.159889e-01 0.038 0 0
Leishmania infection R-HSA-9658195 9.159971e-01 0.038 0 0
Parasitic Infection Pathways R-HSA-9824443 9.159971e-01 0.038 0 0
The phototransduction cascade R-HSA-2514856 9.161985e-01 0.038 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.169741e-01 0.038 0 0
SLC transporter disorders R-HSA-5619102 9.184595e-01 0.037 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.200672e-01 0.036 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.211937e-01 0.036 0 0
Mitochondrial protein degradation R-HSA-9837999 9.218444e-01 0.035 0 0
G alpha (q) signalling events R-HSA-416476 9.224201e-01 0.035 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.249195e-01 0.034 0 0
Neurotransmitter clearance R-HSA-112311 9.249195e-01 0.034 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.249195e-01 0.034 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.253414e-01 0.034 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.253414e-01 0.034 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.253414e-01 0.034 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.253414e-01 0.034 0 0
Choline catabolism R-HSA-6798163 9.253414e-01 0.034 0 0
Specification of primordial germ cells R-HSA-9827857 9.253414e-01 0.034 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.253414e-01 0.034 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.275260e-01 0.033 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.317813e-01 0.031 0 0
Cargo concentration in the ER R-HSA-5694530 9.317813e-01 0.031 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.317813e-01 0.031 0 0
Activation of GABAB receptors R-HSA-991365 9.333877e-01 0.030 0 0
GABA B receptor activation R-HSA-977444 9.333877e-01 0.030 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 9.336533e-01 0.030 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.336533e-01 0.030 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.336533e-01 0.030 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.380465e-01 0.028 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.404431e-01 0.027 0 0
HDL remodeling R-HSA-8964058 9.410402e-01 0.026 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.410402e-01 0.026 0 0
Amino Acid conjugation R-HSA-156587 9.410402e-01 0.026 0 0
Conjugation of carboxylic acids R-HSA-159424 9.410402e-01 0.026 0 0
Diseases of hemostasis R-HSA-9671793 9.410402e-01 0.026 0 0
Specification of the neural plate border R-HSA-9834899 9.410402e-01 0.026 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.410402e-01 0.026 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.410402e-01 0.026 0 0
Regulation of insulin secretion R-HSA-422356 9.421213e-01 0.026 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.424181e-01 0.026 0 0
Cardiogenesis R-HSA-9733709 9.437627e-01 0.025 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.476051e-01 0.023 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.476051e-01 0.023 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.476051e-01 0.023 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.476051e-01 0.023 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.476051e-01 0.023 0 0
Creatine metabolism R-HSA-71288 9.476051e-01 0.023 0 0
Pregnenolone biosynthesis R-HSA-196108 9.476051e-01 0.023 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.489745e-01 0.023 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.489745e-01 0.023 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.489745e-01 0.023 0 0
Heme degradation R-HSA-189483 9.489745e-01 0.023 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.511655e-01 0.022 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.534393e-01 0.021 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.534393e-01 0.021 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.534393e-01 0.021 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.534393e-01 0.021 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.534393e-01 0.021 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.534393e-01 0.021 0 0
eNOS activation R-HSA-203615 9.537233e-01 0.021 0 0
RA biosynthesis pathway R-HSA-5365859 9.537233e-01 0.021 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.537233e-01 0.021 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.548867e-01 0.020 0 0
Triglyceride metabolism R-HSA-8979227 9.548867e-01 0.020 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.562751e-01 0.019 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.580476e-01 0.019 0 0
Metabolism of polyamines R-HSA-351202 9.583447e-01 0.018 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.586242e-01 0.018 0 0
Glutathione synthesis and recycling R-HSA-174403 9.586242e-01 0.018 0 0
Attachment and Entry R-HSA-9694614 9.586242e-01 0.018 0 0
NGF-stimulated transcription R-HSA-9031628 9.602843e-01 0.018 0 0
Glycosphingolipid transport R-HSA-9845576 9.619831e-01 0.017 0 0
Developmental Cell Lineages R-HSA-9734767 9.630712e-01 0.016 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.632320e-01 0.016 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.632320e-01 0.016 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.632320e-01 0.016 0 0
Fructose metabolism R-HSA-5652084 9.632320e-01 0.016 0 0
Reactions specific to the complex N-glycan synthesis pathway R-HSA-975578 9.632320e-01 0.016 0 0
Ethanol oxidation R-HSA-71384 9.632320e-01 0.016 0 0
Cellular hexose transport R-HSA-189200 9.632320e-01 0.016 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.655626e-01 0.015 0 0
Metabolism of folate and pterines R-HSA-196757 9.655626e-01 0.015 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.667019e-01 0.015 0 0
Azathioprine ADME R-HSA-9748787 9.667019e-01 0.015 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.670391e-01 0.015 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.673269e-01 0.014 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.673269e-01 0.014 0 0
Carnitine shuttle R-HSA-200425 9.673269e-01 0.014 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.673269e-01 0.014 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.673269e-01 0.014 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.673269e-01 0.014 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 9.709659e-01 0.013 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.709659e-01 0.013 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.709659e-01 0.013 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.709659e-01 0.013 0 0
Complex III assembly R-HSA-9865881 9.709659e-01 0.013 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.717732e-01 0.012 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.741998e-01 0.011 0 0
Hyaluronan degradation R-HSA-2160916 9.741998e-01 0.011 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.741998e-01 0.011 0 0
Fertilization R-HSA-1187000 9.741998e-01 0.011 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.744583e-01 0.011 0 0
Tryptophan catabolism R-HSA-71240 9.744583e-01 0.011 0 0
Nucleotide biosynthesis R-HSA-8956320 9.745206e-01 0.011 0 0
Kidney development R-HSA-9830369 9.764682e-01 0.010 0 0
Maturation of spike protein R-HSA-9694548 9.768957e-01 0.010 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.768957e-01 0.010 0 0
TRP channels R-HSA-3295583 9.770737e-01 0.010 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.770737e-01 0.010 0 0
Abacavir ADME R-HSA-2161522 9.770737e-01 0.010 0 0
Sphingolipid catabolism R-HSA-9845614 9.770737e-01 0.010 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.796277e-01 0.009 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.796277e-01 0.009 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.796277e-01 0.009 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.805741e-01 0.009 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.811128e-01 0.008 0 0
FCGR activation R-HSA-2029481 9.816416e-01 0.008 0 0
Pyroptosis R-HSA-5620971 9.818972e-01 0.008 0 0
Dectin-2 family R-HSA-5621480 9.822670e-01 0.008 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.839140e-01 0.007 0 0
Surfactant metabolism R-HSA-5683826 9.845787e-01 0.007 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.847130e-01 0.007 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.857063e-01 0.006 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.858069e-01 0.006 0 0
GABA receptor activation R-HSA-977443 9.865397e-01 0.006 0 0
DAG1 glycosylations R-HSA-8931838 9.887142e-01 0.005 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.887142e-01 0.005 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.896933e-01 0.004 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.899718e-01 0.004 0 0
Innate Immune System R-HSA-168249 9.903755e-01 0.004 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.910894e-01 0.004 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.916599e-01 0.004 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.918421e-01 0.004 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.920825e-01 0.003 0 0
Hyaluronan metabolism R-HSA-2142845 9.920825e-01 0.003 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.920825e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.923133e-01 0.003 0 0
Complex IV assembly R-HSA-9864848 9.924784e-01 0.003 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.929649e-01 0.003 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.929649e-01 0.003 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.929649e-01 0.003 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.932182e-01 0.003 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.932355e-01 0.003 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.937491e-01 0.003 0 0
G alpha (s) signalling events R-HSA-418555 9.940544e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.944459e-01 0.002 0 0
Glucuronidation R-HSA-156588 9.944902e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.947404e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.947784e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.947784e-01 0.002 0 0
Paracetamol ADME R-HSA-9753281 9.950353e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.950650e-01 0.002 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.956152e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.959715e-01 0.002 0 0
N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975576 9.961040e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.964166e-01 0.002 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.964513e-01 0.002 0 0
Formation of the cornified envelope R-HSA-6809371 9.967322e-01 0.001 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.969244e-01 0.001 0 0
Heme biosynthesis R-HSA-189451 9.969244e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.970597e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.970597e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.975681e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.975681e-01 0.001 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.975721e-01 0.001 0 0
Methylation R-HSA-156581 9.978428e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.980834e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.981666e-01 0.001 0 0
Adipogenesis R-HSA-9843745 9.984031e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.984364e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.984372e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.984871e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.986106e-01 0.001 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.986106e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.986106e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.986559e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.986560e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.988058e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.988058e-01 0.001 0 0
Peptide ligand-binding receptors R-HSA-375276 9.990704e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.990851e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.990851e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.990851e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.990851e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.990851e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.991105e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.991779e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.992663e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.992753e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.992907e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.993262e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.993262e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.993416e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.994076e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.995810e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.996287e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.996612e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.996880e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.997113e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.997722e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.997779e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998101e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.998581e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.998581e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.998581e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998740e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.998740e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998965e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999006e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999061e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999280e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999303e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999352e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999450e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999562e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.999615e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999635e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999640e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999649e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999658e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999686e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999781e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999798e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999811e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999814e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999838e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999867e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999870e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999907e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999912e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999959e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999964e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999973e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999984e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999985e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999990e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999993e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999993e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999995e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999995e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999995e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999996e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999998e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999998e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999998e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways