ERBB2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O43157 Y1708 EPSD|PSP PLXNB1 KIAA0407 PLXN5 SEP TNWMSICLYTFVRDSVGEPLyMLFRGIKHQVDKGPVDSVTG
O43157 Y1732 EPSD|PSP PLXNB1 KIAA0407 PLXN5 SEP RGIKHQVDKGPVDSVTGKAKyTLNDNRLLREDVEYRPLTLN
O75347 Y75 Sugiyama TBCA EILQEsRMMIPDCQRRLEAAyLDLQRILENEKDLEEAEEyK
P00338 Y10 EPSD|PSP LDHA PIG19 ___________MAtLKDQLIyNLLKEEQtPQNKITVVGVGA
P00338 Y239 Sugiyama LDHA PIG19 GtDKDKEQWKEVHKQVVEsAyEVIKLKGYtSWAIGLSVADL
P00533 Y1069 iPTMNet|EPSD EGFR ERBB ERBB1 HER1 CIDRNGLQsCPIKEDsFLQRyssDPtGALtEDsIDDtFLPV
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P04626 S1054 Sugiyama ERBB2 HER2 MLN19 NEU NGL DPAPGAGGMVHHRHRssstRsGGGDLtLGLEPsEEEAPRsP
P04626 S1100 Sugiyama ERBB2 HER2 MLN19 NEU NGL GAGsDVFDGDLGMGAAKGLQsLPtHDPsPLQRySEDPTVPL
P04626 S1107 Sugiyama ERBB2 HER2 MLN19 NEU NGL DGDLGMGAAKGLQsLPtHDPsPLQRySEDPTVPLPSETDGY
P04626 T1103 Sugiyama ERBB2 HER2 MLN19 NEU NGL sDVFDGDLGMGAAKGLQsLPtHDPsPLQRySEDPTVPLPSE
P04626 Y1023 SIGNOR|EPSD|PSP ERBB2 HER2 MLN19 NEU NGL tFyRSLLEDDDMGDLVDAEEyLVPQQGFFCPDPAPGAGGMV
P04626 Y1112 SIGNOR|EPSD|PSP ERBB2 HER2 MLN19 NEU NGL MGAAKGLQsLPtHDPsPLQRySEDPTVPLPSETDGYVAPLT
P04626 Y1139 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ERBB2 HER2 MLN19 NEU NGL PLPSETDGYVAPLTCSPQPEyVNQPDVRPQPPsPREGPLPA
P04626 Y1196 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ERBB2 HER2 MLN19 NEU NGL GKNGVVKDVFAFGGAVENPEyLTPQGGAAPQPHPPPAFSPA
P04626 Y1221 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ERBB2 HER2 MLN19 NEU NGL GGAAPQPHPPPAFSPAFDNLyyWDQDPPERGAPPstFKGtP
P04626 Y1222 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ERBB2 HER2 MLN19 NEU NGL GAAPQPHPPPAFSPAFDNLyyWDQDPPERGAPPstFKGtPt
P04626 Y1248 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP ERBB2 HER2 MLN19 NEU NGL PERGAPPstFKGtPtAENPEyLGLDVPV_____________
P04626 Y877 EPSD|PSP|Sugiyama ERBB2 HER2 MLN19 NEU NGL NHVKITDFGLARLLDIDEtEyHADGGKVPIKWMALESILRR
P06493 Y15 SIGNOR|EPSD|PSP CDK1 CDC2 CDC28A CDKN1 P34CDC2 ______MEDyTKIEKIGEGtyGVVyKGRHKTTGQVVAMKKI
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07355 Y188 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D RKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVKRKGT
P07355 Y199 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D RAEDGsVIDyELIDQDARDLyDAGVKRKGTDVPKWIsIMTE
P07814 S883 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 QYKEKTGKEyIPGQPPLsQssDssPtRNsEPAGLEtPEAKV
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900 Y313 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238 Y484 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P13667 Y458 Sugiyama PDIA4 ERP70 ERP72 VLEVAKDFPEytFAIADEEDyAGEVKDLGLsEsGEDVNAAI
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P35222 Y654 EPSD|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 EGATAPLTELLHsRNEGVAtyAAAVLFRMSEDKPQDyKKRL
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P42685 S498 Sugiyama FRK PTK5 RAK PTFETLRWKLEDyFETDssysDANNFIR_____________
P42685 Y490 Sugiyama FRK PTK5 RAK WNAEPKERPTFETLRWKLEDyFETDssysDANNFIR_____
P42685 Y497 Sugiyama FRK PTK5 RAK RPTFETLRWKLEDyFETDssysDANNFIR____________
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P51991 Y360 Sugiyama HNRNPA3 HNRPA3 QSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF__
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P60660 Y89 Sugiyama MYL6 HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P63220 Y53 Sugiyama RPS21 QMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRLA
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q01082 S2165 Sugiyama SPTBN1 SPTB2 VDTsEMVNGAtEQRtssKEssPIPsPtsDRKAKTALPAQsA
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q13615 T618 Sugiyama MTMR3 KIAA0371 ZFYVE10 TSPDDPPLSRLPKtRsyDNLttACDNTVPLASRRCsDPSLN
Q58FF8 Y260 Sugiyama HSP90AB2P HSP90BB VRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVW
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q86TC9 S928 Sugiyama MYPN MYOP FEQRLMNEIEFRLERtPVDEsDDEIQHDEIPTGKCIAPIFD
Q86V81 Y250 Sugiyama ALYREF ALY BEF THOC4 AGRNSKQQLsAEELDAQLDAyNARMDts_____________
Q86W56 Y832 Sugiyama PARG DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8NI22 Y135 Sugiyama MCFD2 SDNSF DELINIIDGVLRDDDKNNDGyIDyAEFAKSLQ_________
Q92574 S511 Sugiyama TSC1 KIAA0243 TSC TAEAEPVVPRGGFDsPFyRDsLPGsQRKtHsAAsssQGASV
Q92574 Y508 Sugiyama TSC1 KIAA0243 TSC EITTAEAEPVVPRGGFDsPFyRDsLPGsQRKtHsAAsssQG
Q96N67 Y1257 SIGNOR|EPSD|PSP DOCK7 KIAA1771 RVAMLYLPLIGIIMETVPQLyDFTETHNQRGRPICIATDDY
Q9BQE3 Y432 Sugiyama TUBA1C TUBA6 GMEEGEFSEAREDMAALEKDyEEVGADsADGEDEGEEy___
Q9BXH1 Y152 SIGNOR|EPSD|PSP BBC3 PUMA QWAREIGAQLRRMADDLNAQyERRRQEEQQRHRPSPWRVLy
Q9BXH1 Y172 SIGNOR|EPSD|PSP BBC3 PUMA yERRRQEEQQRHRPSPWRVLyNLIMGLLPLPRGHRAPEMEP
Q9BXH1 Y58 SIGNOR|EPSD|PSP BBC3 PUMA GLCEPGLAAAPAAPTLLPAAyLCAPTAPPAVTAALGGSRWP
Q9H1E3 Y146 Sugiyama NUCKS1 NUCKS JC7 QEKDsGsDEDFLMEDDDDsDyGSsKKKNKKMVKKSKPERKE
Q9HB20 S248 Sugiyama PLEKHA3 FAPP1 PVstLHRLsQRRRRtYsDtDsCsDIPLEDPDRPVHCSKNTL
Q9NWB6 S76 Sugiyama ARGLU1 sRsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLD
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Packaging Of Telomere Ends R-HSA-171306 1.583178e-13 12.800 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.583178e-13 12.800 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.706546e-14 13.244 0 0
DNA methylation R-HSA-5334118 2.968736e-13 12.527 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.815482e-13 12.008 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.133183e-13 12.147 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.404699e-13 12.027 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.600386e-12 11.796 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.600386e-12 11.796 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.652767e-12 11.576 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.384515e-12 11.471 0 0
Cleavage of the damaged purine R-HSA-110331 3.384515e-12 11.471 0 0
Depurination R-HSA-73927 4.293566e-12 11.367 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.323297e-12 11.274 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.800005e-12 11.167 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.800005e-12 11.167 0 0
HDACs deacetylate histones R-HSA-3214815 7.814194e-12 11.107 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.492873e-12 11.071 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.492873e-12 11.071 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.306222e-11 10.884 0 0
Depyrimidination R-HSA-73928 1.306222e-11 10.884 0 0
Defective pyroptosis R-HSA-9710421 1.609124e-11 10.793 0 0
Cell-Cell communication R-HSA-1500931 2.189482e-11 10.660 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.411560e-11 10.618 0 0
Nucleosome assembly R-HSA-774815 2.411560e-11 10.618 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.592659e-11 10.586 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.934719e-11 10.532 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.996747e-11 10.398 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.297829e-11 10.367 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.866507e-11 10.313 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 6.578615e-11 10.182 0 0
Meiotic recombination R-HSA-912446 7.421141e-11 10.130 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.845757e-11 10.053 0 0
Meiotic synapsis R-HSA-1221632 1.051168e-10 9.978 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.051168e-10 9.978 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.173059e-10 9.931 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.245448e-10 9.905 0 0
Assembly of the pre-replicative complex R-HSA-68867 1.566626e-10 9.805 0 0
Adherens junctions interactions R-HSA-418990 1.698448e-10 9.770 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.387218e-10 9.622 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.790647e-10 9.554 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.254268e-10 9.488 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.393628e-10 9.357 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.394205e-10 9.357 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.675520e-10 9.330 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.675520e-10 9.330 0 0
Cell junction organization R-HSA-446728 8.550068e-10 9.068 0 0
DNA Double Strand Break Response R-HSA-5693606 8.960727e-10 9.048 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.075624e-09 8.968 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.341625e-09 8.872 0 0
Cell-cell junction organization R-HSA-421270 1.295901e-09 8.887 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.390230e-09 8.857 1 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.417712e-09 8.848 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.529193e-09 8.816 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.529193e-09 8.816 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.240984e-09 8.650 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.308632e-09 8.637 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.867522e-09 8.542 0 0
RNA Polymerase I Transcription R-HSA-73864 3.646416e-09 8.438 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.609368e-09 8.336 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.171262e-09 8.286 0 0
Amyloid fiber formation R-HSA-977225 5.171262e-09 8.286 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.253852e-09 8.139 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.253852e-09 8.139 0 0
Meiosis R-HSA-1500620 8.081977e-09 8.092 0 0
Gene Silencing by RNA R-HSA-211000 9.583862e-09 8.018 0 0
Diseases of programmed cell death R-HSA-9645723 1.237639e-08 7.907 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.493951e-08 7.826 0 0
Base Excision Repair R-HSA-73884 1.520696e-08 7.818 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.635710e-08 7.786 0 0
Mitotic Prophase R-HSA-68875 3.465450e-08 7.460 0 0
Telomere Maintenance R-HSA-157579 3.643312e-08 7.439 0 0
HATs acetylate histones R-HSA-3214847 4.376295e-08 7.359 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.544351e-08 7.256 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.544351e-08 7.256 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.544351e-08 7.256 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.722401e-08 7.242 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.722401e-08 7.242 0 0
DNA Replication R-HSA-69306 6.062311e-08 7.217 0 0
Signal Transduction R-HSA-162582 6.809520e-08 7.167 1 0
G2/M Checkpoints R-HSA-69481 6.452264e-08 7.190 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.426295e-07 6.846 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.680697e-07 6.775 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.120410e-07 6.674 0 0
Ub-specific processing proteases R-HSA-5689880 2.248367e-07 6.648 0 0
Homology Directed Repair R-HSA-5693538 2.652113e-07 6.576 0 0
Chromosome Maintenance R-HSA-73886 3.302813e-07 6.481 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.798332e-07 6.420 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.811492e-07 6.419 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.871684e-07 6.312 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.607629e-07 6.180 1 0
Reproduction R-HSA-1474165 7.060867e-07 6.151 0 0
Developmental Biology R-HSA-1266738 7.262771e-07 6.139 1 0
Co-inhibition by PD-1 R-HSA-389948 9.677994e-07 6.014 0 0
ESR-mediated signaling R-HSA-8939211 9.993726e-07 6.000 0 0
Signaling by NOTCH R-HSA-157118 1.143348e-06 5.942 0 0
Chromatin organization R-HSA-4839726 1.693352e-06 5.771 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.273427e-06 5.643 0 0
Cellular Senescence R-HSA-2559583 2.181676e-06 5.661 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.451076e-06 5.611 1 1
TCF dependent signaling in response to WNT R-HSA-201681 2.539132e-06 5.595 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.016864e-06 5.520 1 1
DNA Double-Strand Break Repair R-HSA-5693532 3.187428e-06 5.497 0 0
Immune System R-HSA-168256 3.289701e-06 5.483 0 0
Protein ubiquitination R-HSA-8852135 4.129622e-06 5.384 0 0
Adaptive Immune System R-HSA-1280218 4.295942e-06 5.367 0 0
HCMV Early Events R-HSA-9609690 4.757411e-06 5.323 0 0
Chromatin modifying enzymes R-HSA-3247509 4.804610e-06 5.318 0 0
Deubiquitination R-HSA-5688426 1.110323e-05 4.955 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.620668e-05 4.790 1 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.027636e-05 4.693 0 0
Interleukin-2 signaling R-HSA-9020558 1.873063e-05 4.727 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.098813e-05 4.678 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.377802e-05 4.624 1 0
HCMV Late Events R-HSA-9610379 2.458429e-05 4.609 0 0
M Phase R-HSA-68886 3.739204e-05 4.427 0 0
HCMV Infection R-HSA-9609646 4.396354e-05 4.357 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.476032e-05 4.349 1 1
MAPK1/MAPK3 signaling R-HSA-5684996 4.621228e-05 4.335 1 0
Signaling by WNT R-HSA-195721 4.923987e-05 4.308 0 0
Cell Cycle Checkpoints R-HSA-69620 5.795432e-05 4.237 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.390634e-05 4.027 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 9.928982e-05 4.003 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.265109e-04 3.898 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.546738e-04 3.811 1 1
Intracellular signaling by second messengers R-HSA-9006925 1.764822e-04 3.753 1 0
Activation of TRKA receptors R-HSA-187015 1.908742e-04 3.719 0 0
MAPK family signaling cascades R-HSA-5683057 2.013783e-04 3.696 1 0
Cell Cycle, Mitotic R-HSA-69278 2.363049e-04 3.627 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.607912e-04 3.584 1 0
Viral Infection Pathways R-HSA-9824446 2.808622e-04 3.552 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.952535e-04 3.403 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 5.610937e-04 3.251 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.135798e-04 3.212 0 0
Disease R-HSA-1643685 8.490798e-04 3.071 1 0
Signaling by VEGF R-HSA-194138 9.017428e-04 3.045 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 9.026565e-04 3.044 0 0
Signal regulatory protein family interactions R-HSA-391160 1.044920e-03 2.981 0 0
TRKA activation by NGF R-HSA-187042 1.400431e-03 2.854 0 0
Infectious disease R-HSA-5663205 1.490989e-03 2.827 0 0
Interleukin-2 family signaling R-HSA-451927 1.805281e-03 2.743 0 0
FLT3 Signaling R-HSA-9607240 1.947627e-03 2.710 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.002379e-03 2.698 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.088544e-03 2.680 1 0
IRS activation R-HSA-74713 2.706227e-03 2.568 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.255275e-03 2.647 0 0
Potential therapeutics for SARS R-HSA-9679191 2.517053e-03 2.599 0 0
Cell Cycle R-HSA-1640170 2.505355e-03 2.601 0 0
DNA Repair R-HSA-73894 3.029601e-03 2.519 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.285283e-03 2.483 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.285283e-03 2.483 0 0
NGF-independant TRKA activation R-HSA-187024 3.509743e-03 2.455 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.775047e-03 2.423 0 0
Developmental Cell Lineages R-HSA-9734767 3.915706e-03 2.407 1 0
Interleukin-20 family signaling R-HSA-8854691 4.007318e-03 2.397 0 0
STAT5 Activation R-HSA-9645135 4.410727e-03 2.355 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.410727e-03 2.355 0 0
Signaling by Interleukins R-HSA-449147 4.635394e-03 2.334 0 0
Interleukin-7 signaling R-HSA-1266695 4.818705e-03 2.317 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.818705e-03 2.317 1 0
EPH-Ephrin signaling R-HSA-2682334 5.292620e-03 2.276 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.407015e-03 2.267 0 0
Regulation of beta-cell development R-HSA-186712 6.315960e-03 2.200 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.496479e-03 2.187 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.496479e-03 2.187 0 0
Interleukin-9 signaling R-HSA-8985947 6.496479e-03 2.187 0 0
Interleukin-18 signaling R-HSA-9012546 6.496479e-03 2.187 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 6.496479e-03 2.187 0 0
Signaling by Erythropoietin R-HSA-9006335 6.721122e-03 2.173 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.721122e-03 2.173 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.988165e-03 2.156 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 8.946591e-03 2.048 0 0
Interleukin-21 signaling R-HSA-9020958 7.677025e-03 2.115 0 0
PI3K/AKT activation R-HSA-198203 8.946591e-03 2.048 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.470850e-03 2.072 0 0
IGF1R signaling cascade R-HSA-2428924 8.082513e-03 2.092 0 0
Signal attenuation R-HSA-74749 8.946591e-03 2.048 0 0
Signaling by Leptin R-HSA-2586552 8.946591e-03 2.048 0 0
Cellular responses to stimuli R-HSA-8953897 7.752650e-03 2.111 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.402364e-03 2.076 0 0
Signaling by NTRKs R-HSA-166520 9.791446e-03 2.009 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.030315e-02 1.987 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.030315e-02 1.987 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.033953e-02 1.985 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.074760e-02 1.969 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.074760e-02 1.969 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.074760e-02 1.969 0 0
KIT mutants bind TKIs R-HSA-9669921 1.074760e-02 1.969 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.074760e-02 1.969 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.074760e-02 1.969 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.074760e-02 1.969 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.074760e-02 1.969 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.074760e-02 1.969 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.074760e-02 1.969 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.074760e-02 1.969 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.074760e-02 1.969 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.074760e-02 1.969 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.074760e-02 1.969 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.074760e-02 1.969 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.074760e-02 1.969 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.074760e-02 1.969 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.074760e-02 1.969 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.074760e-02 1.969 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.074760e-02 1.969 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.074760e-02 1.969 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.074760e-02 1.969 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.074760e-02 1.969 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.074760e-02 1.969 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.074760e-02 1.969 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.074760e-02 1.969 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.074760e-02 1.969 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.074760e-02 1.969 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.074760e-02 1.969 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.074760e-02 1.969 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.074760e-02 1.969 0 0
GPVI-mediated activation cascade R-HSA-114604 1.170884e-02 1.931 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.174471e-02 1.930 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.655991e-02 1.781 0 0
Interleukin-15 signaling R-HSA-8983432 1.326930e-02 1.877 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.655991e-02 1.781 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.566520e-02 1.805 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.396894e-02 1.855 0 0
Cellular responses to stress R-HSA-2262752 1.762470e-02 1.754 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.787682e-02 1.748 0 0
Erythropoietin activates RAS R-HSA-9027284 1.832216e-02 1.737 0 0
DCC mediated attractive signaling R-HSA-418885 1.832216e-02 1.737 0 0
Signaling by SCF-KIT R-HSA-1433557 1.835722e-02 1.736 0 0
Generic Transcription Pathway R-HSA-212436 1.928502e-02 1.715 1 0
Negative regulation of FLT3 R-HSA-9706369 2.015992e-02 1.696 0 0
Prolonged ERK activation events R-HSA-169893 2.015992e-02 1.696 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.023053e-02 1.694 0 0
Axon guidance R-HSA-422475 2.071401e-02 1.684 1 0
Apoptotic execution phase R-HSA-75153 2.129015e-02 1.672 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.138035e-02 1.670 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 2.207137e-02 1.656 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.207137e-02 1.656 1 1
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.232147e-02 1.651 0 0
Degradation of CDH1 R-HSA-9766229 2.446469e-02 1.611 0 0
Nephron development R-HSA-9831926 2.610827e-02 1.583 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.797216e-02 1.553 0 0
Regulation of signaling by CBL R-HSA-912631 2.823027e-02 1.549 0 0
Leishmania phagocytosis R-HSA-9664417 2.867771e-02 1.542 0 0
Parasite infection R-HSA-9664407 2.867771e-02 1.542 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.867771e-02 1.542 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.935464e-02 1.532 0 0
Formation of definitive endoderm R-HSA-9823730 3.041902e-02 1.517 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.046795e-02 1.516 0 0
Nervous system development R-HSA-9675108 3.159278e-02 1.500 1 0
NTRK3 as a dependence receptor R-HSA-9603505 3.189947e-02 1.496 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.189947e-02 1.496 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.189947e-02 1.496 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.189947e-02 1.496 0 0
Regulation of CDH1 Function R-HSA-9764561 3.410766e-02 1.467 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 3.451890e-02 1.462 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.499019e-02 1.456 0 0
Signaling by KIT in disease R-HSA-9669938 3.736936e-02 1.427 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 3.736936e-02 1.427 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.736936e-02 1.427 1 1
Growth hormone receptor signaling R-HSA-982772 3.980882e-02 1.400 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 4.230615e-02 1.374 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 4.230615e-02 1.374 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 4.230615e-02 1.374 0 0
NTF3 activates NTRK3 signaling R-HSA-9034013 4.230615e-02 1.374 0 0
PLC-gamma1 signalling R-HSA-167021 5.260161e-02 1.279 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.260161e-02 1.279 0 0
MET interacts with TNS proteins R-HSA-8875513 5.260161e-02 1.279 0 0
Signalling to STAT3 R-HSA-198745 5.260161e-02 1.279 0 0
MET activates PTPN11 R-HSA-8865999 5.260161e-02 1.279 0 0
MET activates PTK2 signaling R-HSA-8874081 4.747341e-02 1.324 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.013869e-02 1.300 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.230699e-02 1.374 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.747341e-02 1.324 0 0
Downstream signal transduction R-HSA-186763 6.131326e-02 1.212 0 0
DAP12 signaling R-HSA-2424491 5.844540e-02 1.233 0 0
Interferon alpha/beta signaling R-HSA-909733 5.231594e-02 1.281 0 0
Insulin receptor signalling cascade R-HSA-74751 4.392953e-02 1.357 0 0
MET activates STAT3 R-HSA-8875791 5.260161e-02 1.279 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.562610e-02 1.255 1 1
CD209 (DC-SIGN) signaling R-HSA-5621575 4.230699e-02 1.374 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.956081e-02 1.225 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.167954e-02 1.380 0 0
TCR signaling R-HSA-202403 4.428617e-02 1.354 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.107348e-02 1.386 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.244871e-02 1.372 1 0
Signaling by PTK6 R-HSA-8848021 4.244871e-02 1.372 1 0
Signaling by ALK in cancer R-HSA-9700206 4.107348e-02 1.386 0 0
RNA Polymerase II Transcription R-HSA-73857 4.835675e-02 1.316 1 0
Semaphorin interactions R-HSA-373755 4.244871e-02 1.372 1 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.500249e-02 1.260 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.747341e-02 1.324 0 0
SARS-CoV Infections R-HSA-9679506 4.932213e-02 1.307 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 6.278702e-02 1.202 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 6.278702e-02 1.202 1 1
Regulation of gap junction activity R-HSA-191650 6.278702e-02 1.202 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 6.278702e-02 1.202 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 6.278702e-02 1.202 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.278702e-02 1.202 0 0
Interleukin-12 signaling R-HSA-9020591 6.364799e-02 1.196 0 0
Integrin signaling R-HSA-354192 6.718923e-02 1.173 0 0
Integrin cell surface interactions R-HSA-216083 6.727200e-02 1.172 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 7.286355e-02 1.137 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 7.286355e-02 1.137 0 0
NTRK2 activates RAC1 R-HSA-9032759 7.286355e-02 1.137 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 7.286355e-02 1.137 0 0
Reelin signalling pathway R-HSA-8866376 7.286355e-02 1.137 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 7.286355e-02 1.137 0 0
RAF activation R-HSA-5673000 7.324345e-02 1.135 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.633420e-02 1.117 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.633420e-02 1.117 0 0
Signalling to ERKs R-HSA-187687 7.633420e-02 1.117 0 0
FLT3 signaling in disease R-HSA-9682385 7.946571e-02 1.100 0 0
Voltage gated Potassium channels R-HSA-1296072 8.263677e-02 1.083 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.263677e-02 1.083 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 8.283235e-02 1.082 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 8.283235e-02 1.082 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.283235e-02 1.082 0 0
Phosphorylation of Emi1 R-HSA-176417 8.283235e-02 1.082 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 8.283235e-02 1.082 0 0
Signaling by MST1 R-HSA-8852405 8.283235e-02 1.082 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 8.283235e-02 1.082 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 8.283235e-02 1.082 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 8.283235e-02 1.082 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 8.283235e-02 1.082 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 8.283235e-02 1.082 0 0
MET promotes cell motility R-HSA-8875878 8.584616e-02 1.066 0 0
Interleukin-12 family signaling R-HSA-447115 8.674271e-02 1.062 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.694847e-02 1.061 0 0
Signaling by ALK R-HSA-201556 8.909271e-02 1.050 0 0
Generation of second messenger molecules R-HSA-202433 9.237526e-02 1.034 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 9.269458e-02 1.033 0 0
MET Receptor Activation R-HSA-6806942 9.269458e-02 1.033 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 1.024514e-01 0.989 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.024514e-01 0.989 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.024514e-01 0.989 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.024514e-01 0.989 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.024514e-01 0.989 0 0
SOS-mediated signalling R-HSA-112412 1.024514e-01 0.989 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.121038e-01 0.950 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 1.121038e-01 0.950 0 0
MET receptor recycling R-HSA-8875656 1.121038e-01 0.950 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.121038e-01 0.950 0 0
ARMS-mediated activation R-HSA-170984 1.216531e-01 0.915 0 0
ALK mutants bind TKIs R-HSA-9700645 1.216531e-01 0.915 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.311002e-01 0.882 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.311002e-01 0.882 0 0
PECAM1 interactions R-HSA-210990 1.404463e-01 0.852 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.404463e-01 0.852 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.496924e-01 0.825 0 0
MET activates RAS signaling R-HSA-8851805 1.588397e-01 0.799 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.588397e-01 0.799 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.588397e-01 0.799 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.588397e-01 0.799 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.678891e-01 0.775 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.678891e-01 0.775 0 0
Regulation of KIT signaling R-HSA-1433559 1.768417e-01 0.752 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.768417e-01 0.752 1 1
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.856985e-01 0.731 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.856985e-01 0.731 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.856985e-01 0.731 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.856985e-01 0.731 1 1
Signaling by RAF1 mutants R-HSA-9656223 9.904385e-02 1.004 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.162681e-01 0.935 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.162681e-01 0.935 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.415093e-01 0.849 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.024514e-01 0.989 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.496924e-01 0.825 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.162681e-01 0.935 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.162681e-01 0.935 0 0
MAP2K and MAPK activation R-HSA-5674135 9.904385e-02 1.004 0 0
Regulation of CDH11 function R-HSA-9762292 1.311002e-01 0.882 0 0
Signaling by RAS mutants R-HSA-6802949 1.162681e-01 0.935 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 1.121038e-01 0.950 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.754321e-01 0.756 0 0
Signaling by PDGF R-HSA-186797 1.754321e-01 0.756 0 0
Interleukin-6 signaling R-HSA-1059683 1.678891e-01 0.775 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.678891e-01 0.775 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 1.678891e-01 0.775 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 1.024514e-01 0.989 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.588397e-01 0.799 0 0
Signaling by Insulin receptor R-HSA-74752 9.944085e-02 1.002 0 0
Interleukin-23 signaling R-HSA-9020933 1.121038e-01 0.950 0 0
Proteasome assembly R-HSA-9907900 1.092890e-01 0.961 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.311002e-01 0.882 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 1.311002e-01 0.882 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.588397e-01 0.799 1 1
VLDLR internalisation and degradation R-HSA-8866427 1.588397e-01 0.799 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.856985e-01 0.731 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.452061e-01 0.838 0 0
Dectin-2 family R-HSA-5621480 1.564132e-01 0.806 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 1.016266e-01 0.993 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.244965e-01 0.905 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 1.644400e-01 0.784 0 0
IRS-mediated signalling R-HSA-112399 1.564132e-01 0.806 0 0
Cellular response to heat stress R-HSA-3371556 1.803014e-01 0.744 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.216531e-01 0.915 0 0
Interleukin-27 signaling R-HSA-9020956 1.311002e-01 0.882 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.768417e-01 0.752 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.245613e-01 0.905 0 0
Frs2-mediated activation R-HSA-170968 1.678891e-01 0.775 0 0
Smooth Muscle Contraction R-HSA-445355 1.415093e-01 0.849 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.127643e-01 0.948 0 0
DAP12 interactions R-HSA-2172127 1.092890e-01 0.961 0 0
FCERI mediated MAPK activation R-HSA-2871796 1.515641e-01 0.819 0 0
MAPK1 (ERK2) activation R-HSA-112411 1.216531e-01 0.915 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 1.588397e-01 0.799 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.292782e-01 0.888 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.904385e-02 1.004 0 0
Netrin-1 signaling R-HSA-373752 1.092890e-01 0.961 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 1.768417e-01 0.752 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.566749e-01 0.805 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.311002e-01 0.882 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.588397e-01 0.799 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.216531e-01 0.915 0 0
Gene expression (Transcription) R-HSA-74160 1.263228e-01 0.899 1 0
Kinesins R-HSA-983189 1.677782e-01 0.775 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.404463e-01 0.852 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 1.404463e-01 0.852 0 0
Pervasive developmental disorders R-HSA-9005895 1.588397e-01 0.799 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.588397e-01 0.799 0 0
Disorders of Nervous System Development R-HSA-9697154 1.588397e-01 0.799 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.856985e-01 0.731 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.105586e-01 0.956 0 0
PI3K Cascade R-HSA-109704 1.305481e-01 0.884 0 0
Interleukin-35 Signalling R-HSA-8984722 1.588397e-01 0.799 0 0
MHC class II antigen presentation R-HSA-2132295 1.856791e-01 0.731 0 0
Prolactin receptor signaling R-HSA-1170546 1.768417e-01 0.752 0 0
NRAGE signals death through JNK R-HSA-193648 1.526588e-01 0.816 0 0
Hemostasis R-HSA-109582 9.785124e-02 1.009 0 0
RSV-host interactions R-HSA-9833110 1.316934e-01 0.880 0 0
Signaling by LTK R-HSA-9842663 1.588397e-01 0.799 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.856985e-01 0.731 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.856985e-01 0.731 0 0
Interleukin-1 family signaling R-HSA-446652 1.136940e-01 0.944 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.749676e-01 0.757 0 0
Azathioprine ADME R-HSA-9748787 1.305481e-01 0.884 0 0
Dissolution of Fibrin Clot R-HSA-75205 1.404463e-01 0.852 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.092890e-01 0.961 1 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.174493e-01 0.930 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 9.512788e-02 1.022 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.233571e-01 0.909 0 0
Apoptosis R-HSA-109581 1.320429e-01 0.879 0 0
Death Receptor Signaling R-HSA-73887 1.172679e-01 0.931 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.870136e-01 0.728 0 0
Cellular response to hypoxia R-HSA-1234174 1.870136e-01 0.728 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.870136e-01 0.728 0 0
Host Interactions of HIV factors R-HSA-162909 1.883839e-01 0.725 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.944606e-01 0.711 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 1.944606e-01 0.711 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.944606e-01 0.711 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 1.944606e-01 0.711 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 1.944606e-01 0.711 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.944606e-01 0.711 0 0
Differentiation of T cells R-HSA-9945266 1.944606e-01 0.711 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 1.944606e-01 0.711 0 0
Kidney development R-HSA-9830369 1.947934e-01 0.710 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.000174e-01 0.699 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.026139e-01 0.693 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 2.031289e-01 0.692 0 0
Disorders of Developmental Biology R-HSA-9675151 2.031289e-01 0.692 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.031289e-01 0.692 0 0
Innate Immune System R-HSA-168249 2.085973e-01 0.681 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.104696e-01 0.677 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.104696e-01 0.677 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.117045e-01 0.674 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 2.117045e-01 0.674 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.117045e-01 0.674 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.117045e-01 0.674 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 2.117045e-01 0.674 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.117045e-01 0.674 1 1
Signaling by Hippo R-HSA-2028269 2.117045e-01 0.674 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.144092e-01 0.669 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.159546e-01 0.666 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.183557e-01 0.661 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.183557e-01 0.661 0 0
Platelet sensitization by LDL R-HSA-432142 2.201883e-01 0.657 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 2.201883e-01 0.657 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.201883e-01 0.657 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.201883e-01 0.657 0 0
GAB1 signalosome R-HSA-180292 2.201883e-01 0.657 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.201883e-01 0.657 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 2.201883e-01 0.657 0 0
mRNA Splicing R-HSA-72172 2.246958e-01 0.648 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.262673e-01 0.645 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.262673e-01 0.645 0 0
Programmed Cell Death R-HSA-5357801 2.269785e-01 0.644 0 0
Leishmania infection R-HSA-9658195 2.275020e-01 0.643 0 0
Parasitic Infection Pathways R-HSA-9824443 2.275020e-01 0.643 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 2.285813e-01 0.641 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.285813e-01 0.641 0 0
Rap1 signalling R-HSA-392517 2.285813e-01 0.641 0 0
Other interleukin signaling R-HSA-449836 2.285813e-01 0.641 0 0
Integration of energy metabolism R-HSA-163685 2.300486e-01 0.638 0 0
Negative regulation of MET activity R-HSA-6807004 2.368845e-01 0.625 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.368845e-01 0.625 0 0
Signal transduction by L1 R-HSA-445144 2.368845e-01 0.625 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.368845e-01 0.625 1 1
PCP/CE pathway R-HSA-4086400 2.381722e-01 0.623 0 0
G alpha (12/13) signalling events R-HSA-416482 2.381722e-01 0.623 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.450989e-01 0.611 0 0
Signalling to RAS R-HSA-167044 2.450989e-01 0.611 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 2.450989e-01 0.611 0 0
Basigin interactions R-HSA-210991 2.450989e-01 0.611 0 0
Signaling by MET R-HSA-6806834 2.461274e-01 0.609 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.461274e-01 0.609 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.500541e-01 0.602 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.532253e-01 0.596 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.532253e-01 0.596 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.532253e-01 0.596 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.532253e-01 0.596 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.612647e-01 0.583 0 0
Notch-HLH transcription pathway R-HSA-350054 2.612647e-01 0.583 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 2.612647e-01 0.583 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.612647e-01 0.583 0 0
LDL clearance R-HSA-8964038 2.612647e-01 0.583 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 2.612647e-01 0.583 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.660501e-01 0.575 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.692181e-01 0.570 0 0
Termination of O-glycan biosynthesis R-HSA-977068 2.692181e-01 0.570 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.692181e-01 0.570 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.692181e-01 0.570 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.692181e-01 0.570 0 0
Biosynthesis of maresins R-HSA-9018682 2.692181e-01 0.570 0 0
Gastrulation R-HSA-9758941 2.703101e-01 0.568 0 0
Interferon Signaling R-HSA-913531 2.728919e-01 0.564 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 2.770864e-01 0.557 0 0
Interleukin-6 family signaling R-HSA-6783589 2.770864e-01 0.557 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.770864e-01 0.557 1 1
Chaperonin-mediated protein folding R-HSA-390466 2.780081e-01 0.556 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 2.790498e-01 0.554 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.808946e-01 0.551 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 2.832884e-01 0.548 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 2.848704e-01 0.545 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 2.848704e-01 0.545 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.848704e-01 0.545 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.848704e-01 0.545 0 0
Myogenesis R-HSA-525793 2.925711e-01 0.534 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.925711e-01 0.534 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.925711e-01 0.534 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.001893e-01 0.523 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 3.001893e-01 0.523 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 3.001893e-01 0.523 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.001893e-01 0.523 0 0
Protein folding R-HSA-391251 3.018776e-01 0.520 0 0
Insulin receptor recycling R-HSA-77387 3.077259e-01 0.512 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.077259e-01 0.512 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.151819e-01 0.501 1 1
Regulation of CDH11 Expression and Function R-HSA-9759475 3.151819e-01 0.501 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 3.151819e-01 0.501 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 3.216697e-01 0.493 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.216697e-01 0.493 0 0
Potassium Channels R-HSA-1296071 3.216697e-01 0.493 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.225580e-01 0.491 1 1
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.225580e-01 0.491 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.225580e-01 0.491 1 1
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.225580e-01 0.491 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.225580e-01 0.491 1 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 3.225580e-01 0.491 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.298551e-01 0.482 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.298551e-01 0.482 0 0
Trafficking of AMPA receptors R-HSA-399719 3.298551e-01 0.482 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 3.298551e-01 0.482 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 3.298551e-01 0.482 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.298551e-01 0.482 0 0
Extracellular matrix organization R-HSA-1474244 3.302851e-01 0.481 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.370740e-01 0.472 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.370740e-01 0.472 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.370740e-01 0.472 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.413234e-01 0.467 0 0
Interleukin-1 signaling R-HSA-9020702 3.413234e-01 0.467 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.442157e-01 0.463 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.442157e-01 0.463 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.442157e-01 0.463 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.442157e-01 0.463 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.442157e-01 0.463 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.442157e-01 0.463 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.495123e-01 0.457 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.512808e-01 0.454 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.512808e-01 0.454 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.512808e-01 0.454 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.582702e-01 0.446 0 0
Nuclear import of Rev protein R-HSA-180746 3.582702e-01 0.446 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.582702e-01 0.446 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.582702e-01 0.446 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.582702e-01 0.446 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 3.582702e-01 0.446 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.651848e-01 0.437 0 0
Regulation of Apoptosis R-HSA-169911 3.651848e-01 0.437 0 0
Synthesis of DNA R-HSA-69239 3.685308e-01 0.434 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.720253e-01 0.429 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.720253e-01 0.429 0 0
HSF1 activation R-HSA-3371511 3.720253e-01 0.429 0 0
RUNX2 regulates bone development R-HSA-8941326 3.720253e-01 0.429 0 0
RET signaling R-HSA-8853659 3.720253e-01 0.429 0 0
Degradation of DVL R-HSA-4641258 3.787925e-01 0.422 0 0
Degradation of AXIN R-HSA-4641257 3.787925e-01 0.422 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.787925e-01 0.422 0 0
SLC-mediated transport of organic cations R-HSA-549127 3.787925e-01 0.422 0 0
G2/M Transition R-HSA-69275 3.817033e-01 0.418 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.854872e-01 0.414 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.854872e-01 0.414 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.875239e-01 0.412 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.921101e-01 0.407 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 3.921101e-01 0.407 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.921101e-01 0.407 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.921101e-01 0.407 0 0
RAS processing R-HSA-9648002 3.921101e-01 0.407 0 0
Stabilization of p53 R-HSA-69541 3.921101e-01 0.407 0 0
Attenuation phase R-HSA-3371568 3.986621e-01 0.399 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.986621e-01 0.399 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.986621e-01 0.399 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.986621e-01 0.399 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.048125e-01 0.393 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 4.051439e-01 0.392 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.051439e-01 0.392 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.051439e-01 0.392 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.051439e-01 0.392 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.051439e-01 0.392 0 0
L1CAM interactions R-HSA-373760 4.103563e-01 0.387 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.115561e-01 0.386 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.115561e-01 0.386 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.115561e-01 0.386 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.115561e-01 0.386 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.115561e-01 0.386 0 0
Neutrophil degranulation R-HSA-6798695 4.133912e-01 0.384 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.178997e-01 0.379 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.221438e-01 0.375 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.241753e-01 0.372 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 4.303836e-01 0.366 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.303836e-01 0.366 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.303836e-01 0.366 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.365253e-01 0.360 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.365253e-01 0.360 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.365253e-01 0.360 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.365253e-01 0.360 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.365253e-01 0.360 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.365253e-01 0.360 0 0
Somitogenesis R-HSA-9824272 4.365253e-01 0.360 0 0
Formation of the cornified envelope R-HSA-6809371 4.399176e-01 0.357 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.426012e-01 0.354 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 4.426012e-01 0.354 0 0
Recycling pathway of L1 R-HSA-437239 4.486119e-01 0.348 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.486119e-01 0.348 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.486119e-01 0.348 0 0
Platelet degranulation R-HSA-114608 4.543949e-01 0.343 0 0
Co-stimulation by CD28 R-HSA-389356 4.545582e-01 0.342 0 0
Gap junction trafficking and regulation R-HSA-157858 4.604408e-01 0.337 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.604408e-01 0.337 0 0
Chemokine receptors bind chemokines R-HSA-380108 4.604408e-01 0.337 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.604408e-01 0.337 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.604408e-01 0.337 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.662602e-01 0.331 0 0
Mitotic Anaphase R-HSA-68882 4.699987e-01 0.328 0 0
HSF1-dependent transactivation R-HSA-3371571 4.720173e-01 0.326 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.720173e-01 0.326 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.720173e-01 0.326 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.720173e-01 0.326 0 0
The phototransduction cascade R-HSA-2514856 4.720173e-01 0.326 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.727608e-01 0.325 0 0
Circadian clock R-HSA-9909396 4.757060e-01 0.323 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.777126e-01 0.321 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.777126e-01 0.321 0 0
Orc1 removal from chromatin R-HSA-68949 4.777126e-01 0.321 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.777126e-01 0.321 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.777126e-01 0.321 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.792091e-01 0.319 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.833468e-01 0.316 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.833468e-01 0.316 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.930782e-01 0.307 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.944346e-01 0.306 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.944346e-01 0.306 0 0
G alpha (z) signalling events R-HSA-418597 4.944346e-01 0.306 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.998894e-01 0.301 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 4.998894e-01 0.301 0 0
Signaling by EGFR R-HSA-177929 4.998894e-01 0.301 0 0
TNF signaling R-HSA-75893 4.998894e-01 0.301 0 0
HIV Infection R-HSA-162906 5.000140e-01 0.301 0 0
PTEN Regulation R-HSA-6807070 5.033269e-01 0.298 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.052857e-01 0.296 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.106242e-01 0.292 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 5.106242e-01 0.292 0 0
Amino acid transport across the plasma membrane R-HSA-352230 5.159053e-01 0.287 0 0
Signaling by ERBB2 R-HSA-1227986 5.211298e-01 0.283 1 1
Regulation of PTEN gene transcription R-HSA-8943724 5.211298e-01 0.283 0 0
Metabolism of polyamines R-HSA-351202 5.211298e-01 0.283 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 5.211298e-01 0.283 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.211298e-01 0.283 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.211298e-01 0.283 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.211298e-01 0.283 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.211298e-01 0.283 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.211298e-01 0.283 0 0
FCERI mediated NF-kB activation R-HSA-2871837 5.234217e-01 0.281 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.262982e-01 0.279 0 0
MAP kinase activation R-HSA-450294 5.262982e-01 0.279 0 0
Endogenous sterols R-HSA-211976 5.262982e-01 0.279 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.262982e-01 0.279 0 0
Cell surface interactions at the vascular wall R-HSA-202733 5.265454e-01 0.279 0 0
Heme signaling R-HSA-9707616 5.314112e-01 0.275 0 0
tRNA processing in the nucleus R-HSA-6784531 5.314112e-01 0.275 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.314112e-01 0.275 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.314112e-01 0.275 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.314112e-01 0.275 0 0
Complex I biogenesis R-HSA-6799198 5.364692e-01 0.270 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.364692e-01 0.270 0 0
S Phase R-HSA-69242 5.365140e-01 0.270 0 0
CD22 mediated BCR regulation R-HSA-5690714 5.414730e-01 0.266 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.414730e-01 0.266 0 0
Xenobiotics R-HSA-211981 5.414730e-01 0.266 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.556879e-01 0.255 0 0
SLC-mediated transport of amino acids R-HSA-9958863 5.561644e-01 0.255 0 0
PPARA activates gene expression R-HSA-1989781 5.588289e-01 0.253 0 0
O-linked glycosylation of mucins R-HSA-913709 5.609568e-01 0.251 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.609568e-01 0.251 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 5.650636e-01 0.248 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.662714e-01 0.247 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.703877e-01 0.244 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 5.703877e-01 0.244 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.703877e-01 0.244 0 0
Interleukin-17 signaling R-HSA-448424 5.703877e-01 0.244 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.703877e-01 0.244 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.703877e-01 0.244 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 5.750274e-01 0.240 0 0
Hedgehog 'on' state R-HSA-5632684 5.750274e-01 0.240 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 5.796172e-01 0.237 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.796172e-01 0.237 0 0
Signaling by NOTCH4 R-HSA-9013694 5.886495e-01 0.230 0 0
Signaling by ERBB4 R-HSA-1236394 5.886495e-01 0.230 0 0
Signaling by FGFR in disease R-HSA-1226099 5.886495e-01 0.230 0 0
UCH proteinases R-HSA-5689603 5.974889e-01 0.224 0 0
Signaling by NOTCH1 R-HSA-1980143 5.974889e-01 0.224 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.018375e-01 0.221 0 0
Cellular response to chemical stress R-HSA-9711123 6.035853e-01 0.219 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.061394e-01 0.217 0 0
Interleukin-10 signaling R-HSA-6783783 6.061394e-01 0.217 0 0
ABC transporter disorders R-HSA-5619084 6.061394e-01 0.217 0 0
Sensory processing of sound R-HSA-9659379 6.103950e-01 0.214 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.103950e-01 0.214 0 0
Neuronal System R-HSA-112316 6.110947e-01 0.214 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.146050e-01 0.211 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 6.187697e-01 0.208 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.187697e-01 0.208 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.211328e-01 0.207 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.269653e-01 0.203 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.269653e-01 0.203 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.309972e-01 0.200 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.349858e-01 0.197 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.349858e-01 0.197 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.355752e-01 0.197 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.375471e-01 0.195 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.389315e-01 0.195 0 0
ER-Phagosome pathway R-HSA-1236974 6.542947e-01 0.184 0 0
Neurotransmitter release cycle R-HSA-112310 6.580328e-01 0.182 0 0
Downstream TCR signaling R-HSA-202424 6.580328e-01 0.182 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.690078e-01 0.175 0 0
FCGR activation R-HSA-2029481 6.725877e-01 0.172 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.830981e-01 0.166 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.865265e-01 0.163 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.932730e-01 0.159 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.932730e-01 0.159 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.932730e-01 0.159 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.932730e-01 0.159 0 0
Regulation of insulin secretion R-HSA-422356 6.932730e-01 0.159 0 0
Signaling by ROBO receptors R-HSA-376176 6.934131e-01 0.159 0 0
Hedgehog 'off' state R-HSA-5610787 6.998752e-01 0.155 0 0
ABC-family proteins mediated transport R-HSA-382556 6.998752e-01 0.155 0 0
Keratinization R-HSA-6805567 7.027609e-01 0.153 0 0
PI Metabolism R-HSA-1483255 7.063360e-01 0.151 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.126585e-01 0.147 0 0
Muscle contraction R-HSA-397014 7.163400e-01 0.145 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.188457e-01 0.143 0 0
Platelet homeostasis R-HSA-418346 7.218894e-01 0.142 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.218894e-01 0.142 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.278790e-01 0.138 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.278790e-01 0.138 0 0
Stimuli-sensing channels R-HSA-2672351 7.278790e-01 0.138 0 0
Drug ADME R-HSA-9748784 7.293977e-01 0.137 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 7.308254e-01 0.136 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.308254e-01 0.136 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.337402e-01 0.134 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.337402e-01 0.134 0 0
Post-translational protein modification R-HSA-597592 7.385997e-01 0.132 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.422975e-01 0.129 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.478500e-01 0.126 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.505814e-01 0.125 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.532834e-01 0.123 0 0
Mitochondrial biogenesis R-HSA-1592230 7.586004e-01 0.120 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.638035e-01 0.117 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.638035e-01 0.117 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.688951e-01 0.114 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.713998e-01 0.113 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.713998e-01 0.113 0 0
G1/S Transition R-HSA-69206 7.811516e-01 0.107 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.835242e-01 0.106 0 0
Adipogenesis R-HSA-9843745 7.972323e-01 0.098 0 0
Degradation of the extracellular matrix R-HSA-1474228 7.994315e-01 0.097 0 0
O-linked glycosylation R-HSA-5173105 8.121377e-01 0.090 0 0
Ribosome-associated quality control R-HSA-9948299 8.141761e-01 0.089 0 0
Signaling by Hedgehog R-HSA-5358351 8.141761e-01 0.089 0 0
Macroautophagy R-HSA-1632852 8.201605e-01 0.086 0 0
Bacterial Infection Pathways R-HSA-9824439 8.233317e-01 0.084 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.240432e-01 0.084 0 0
Clathrin-mediated endocytosis R-HSA-8856828 8.259532e-01 0.083 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 8.259532e-01 0.083 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 8.315604e-01 0.080 0 0
SLC-mediated transmembrane transport R-HSA-425407 8.319596e-01 0.080 0 0
Visual phototransduction R-HSA-2187338 8.333892e-01 0.079 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.351983e-01 0.078 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 8.387581e-01 0.076 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.405093e-01 0.075 0 0
Arachidonate metabolism R-HSA-2142753 8.422415e-01 0.075 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.422415e-01 0.075 0 0
Protein localization R-HSA-9609507 8.439550e-01 0.074 0 0
Autophagy R-HSA-9612973 8.489853e-01 0.071 0 0
HIV Life Cycle R-HSA-162587 8.506260e-01 0.070 0 0
Membrane Trafficking R-HSA-199991 8.524907e-01 0.069 0 0
Interferon gamma signaling R-HSA-877300 8.538544e-01 0.069 0 0
Separation of Sister Chromatids R-HSA-2467813 8.616250e-01 0.065 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 8.660887e-01 0.062 0 0
tRNA processing R-HSA-72306 8.718184e-01 0.060 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.759551e-01 0.058 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.759551e-01 0.058 0 0
Respiratory electron transport R-HSA-611105 8.825567e-01 0.054 0 0
Influenza Infection R-HSA-168255 8.838345e-01 0.054 0 0
Transmission across Chemical Synapses R-HSA-112315 8.870058e-01 0.052 0 0
Vesicle-mediated transport R-HSA-5653656 8.881029e-01 0.052 0 0
Diseases of glycosylation R-HSA-3781865 8.900190e-01 0.051 0 0
Peptide ligand-binding receptors R-HSA-375276 8.924001e-01 0.049 0 0
Ion channel transport R-HSA-983712 8.958760e-01 0.048 0 0
Toll-like Receptor Cascades R-HSA-168898 8.981311e-01 0.047 0 0
Mitotic Prometaphase R-HSA-68877 9.003375e-01 0.046 0 0
Metabolism of RNA R-HSA-8953854 9.048329e-01 0.043 0 0
Sphingolipid metabolism R-HSA-428157 9.086982e-01 0.042 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.199494e-01 0.036 0 0
Neddylation R-HSA-8951664 9.274729e-01 0.033 0 0
Metabolism of nucleotides R-HSA-15869 9.384814e-01 0.028 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.454828e-01 0.024 0 0
G alpha (i) signalling events R-HSA-418594 9.470245e-01 0.024 0 0
Fatty acid metabolism R-HSA-8978868 9.470245e-01 0.024 0 0
G alpha (q) signalling events R-HSA-416476 9.547760e-01 0.020 0 0
Metabolism of proteins R-HSA-392499 9.547856e-01 0.020 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.612331e-01 0.017 0 0
Transport of small molecules R-HSA-382551 9.628494e-01 0.016 0 0
Phospholipid metabolism R-HSA-1483257 9.678533e-01 0.014 0 0
GPCR downstream signalling R-HSA-388396 9.743968e-01 0.011 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.756004e-01 0.011 0 0
Metabolism of steroids R-HSA-8957322 9.766545e-01 0.010 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.806517e-01 0.008 0 0
Signaling by GPCR R-HSA-372790 9.868654e-01 0.006 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.893591e-01 0.005 0 0
Diseases of metabolism R-HSA-5668914 9.926235e-01 0.003 0 0
Translation R-HSA-72766 9.927856e-01 0.003 0 0
Biological oxidations R-HSA-211859 9.974705e-01 0.001 0 0
Metabolism of lipids R-HSA-556833 9.976758e-01 0.001 0 0
GPCR ligand binding R-HSA-500792 9.987927e-01 0.001 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.991286e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999888e-01 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.000000e+00 0.000 1 1
GRB2 events in ERBB2 signaling R-HSA-1963640 1.000000e+00 0.000 1 1
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.000000e+00 0.000 1 1
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.000000e+00 0.000 1 1
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.000000e+00 0.000 1 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.000000e+00 0.000 1 1
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.000000e+00 0.000 1 1
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.000000e+00 0.000 1 1
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.000000e+00 0.000 1 1
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.000000e+00 0.000 1 1
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.000000e+00 0.000 1 1
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.000000e+00 0.000 1 1
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.000000e+00 0.000 1 1
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.000000e+00 0.000 1 1
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Attenuation phase R-HSA-3371568 1.110223e-16 15.955 0 0
HSF1-dependent transactivation R-HSA-3371571 1.110223e-16 15.955 0 0
HSF1 activation R-HSA-3371511 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 2.220557e-12 11.654 0 0
Cellular responses to stress R-HSA-2262752 1.525080e-11 10.817 0 0
Apoptosis R-HSA-109581 1.576220e-06 5.802 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.478994e-06 5.830 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.965745e-06 5.706 0 0
Programmed Cell Death R-HSA-5357801 2.733362e-06 5.563 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.021894e-06 5.520 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.000223e-06 5.398 1 1
Activation of BH3-only proteins R-HSA-114452 4.691940e-06 5.329 0 0
G2/M Checkpoints R-HSA-69481 7.429201e-06 5.129 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 9.518511e-06 5.021 0 0
Signaling by ERBB2 R-HSA-1227986 1.688712e-05 4.772 1 1
Transcriptional Regulation by TP53 R-HSA-3700989 1.627953e-05 4.788 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.405366e-05 4.468 0 0
Signaling by LTK R-HSA-9842663 4.073164e-05 4.390 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.470716e-05 4.262 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.013904e-05 4.154 1 1
Activation of BAD and translocation to mitochondria R-HSA-111447 7.884142e-05 4.103 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.884142e-05 4.103 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 7.884142e-05 4.103 0 0
PKR-mediated signaling R-HSA-9833482 8.464935e-05 4.072 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.129967e-05 4.040 1 0
SARS-CoV-1 Infection R-HSA-9678108 1.007258e-04 3.997 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.155622e-04 3.937 1 1
Axon guidance R-HSA-422475 1.136472e-04 3.944 1 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.135055e-04 3.945 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.633256e-04 3.787 1 1
Chaperone Mediated Autophagy R-HSA-9613829 1.633256e-04 3.787 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.681058e-04 3.774 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.321195e-04 3.634 0 0
Nervous system development R-HSA-9675108 2.453991e-04 3.610 1 0
RAF/MAP kinase cascade R-HSA-5673001 2.864166e-04 3.543 1 1
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.430118e-04 3.465 1 1
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.483376e-04 3.458 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 3.721092e-04 3.429 1 0
MAPK family signaling cascades R-HSA-5683057 3.844451e-04 3.415 1 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.440023e-04 3.353 1 1
Cell Cycle Checkpoints R-HSA-69620 4.388364e-04 3.358 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.284638e-04 3.368 0 0
Manipulation of host energy metabolism R-HSA-9636667 5.836765e-04 3.234 0 0
Cell-Cell communication R-HSA-1500931 5.988435e-04 3.223 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 6.157192e-04 3.211 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.029798e-03 2.987 1 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.029798e-03 2.987 1 1
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.029798e-03 2.987 1 1
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.029798e-03 2.987 1 1
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.029798e-03 2.987 1 1
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.029798e-03 2.987 1 1
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.029798e-03 2.987 1 1
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.029798e-03 2.987 1 1
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.029798e-03 2.987 1 1
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.029798e-03 2.987 1 1
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.029798e-03 2.987 1 1
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 9.036784e-04 3.044 1 1
SHC-related events triggered by IGF1R R-HSA-2428933 9.036784e-04 3.044 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.866009e-04 3.104 1 1
Signaling by ERBB2 in Cancer R-HSA-1227990 8.725952e-04 3.059 1 0
Translation initiation complex formation R-HSA-72649 8.352699e-04 3.078 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.610629e-04 3.017 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 8.725952e-04 3.059 1 1
Smooth Muscle Contraction R-HSA-445355 7.771902e-04 3.109 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.064100e-03 2.973 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.100422e-03 2.958 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.190593e-03 2.924 1 0
Striated Muscle Contraction R-HSA-390522 1.283332e-03 2.892 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.513975e-03 2.820 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.513975e-03 2.820 0 0
Neutrophil degranulation R-HSA-6798695 1.443905e-03 2.840 0 0
Protein methylation R-HSA-8876725 1.475410e-03 2.831 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.403984e-03 2.853 0 0
Semaphorin interactions R-HSA-373755 1.513975e-03 2.820 1 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.532587e-03 2.815 1 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.739908e-03 2.759 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.811301e-03 2.742 0 0
Adherens junctions interactions R-HSA-418990 1.959552e-03 2.708 0 0
Cell Cycle R-HSA-1640170 2.118213e-03 2.674 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.233244e-03 2.651 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.233244e-03 2.651 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.282170e-03 2.642 1 1
Transcriptional Regulation by VENTX R-HSA-8853884 2.478133e-03 2.606 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.668737e-03 2.574 0 0
Cell junction organization R-HSA-446728 2.651854e-03 2.576 0 0
G2/M Transition R-HSA-69275 2.856448e-03 2.544 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.866283e-03 2.543 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.907770e-03 2.536 1 0
Centrosome maturation R-HSA-380287 2.960020e-03 2.529 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.028224e-03 2.519 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.028224e-03 2.519 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.564275e-03 2.448 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.564275e-03 2.448 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.195379e-03 2.495 1 1
Formation of definitive endoderm R-HSA-9823730 3.195379e-03 2.495 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.294106e-03 2.482 1 0
MITF-M-dependent gene expression R-HSA-9856651 3.636648e-03 2.439 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.763486e-03 2.424 0 0
Apoptotic execution phase R-HSA-75153 3.763486e-03 2.424 0 0
Phosphorylation of Emi1 R-HSA-176417 3.996235e-03 2.398 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.033688e-03 2.394 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.127673e-03 2.384 0 0
Gluconeogenesis R-HSA-70263 4.276261e-03 2.369 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.560401e-03 2.341 0 0
Cell-cell junction organization R-HSA-421270 4.575260e-03 2.340 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.822850e-03 2.317 0 0
Peptide chain elongation R-HSA-156902 5.676097e-03 2.246 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.676097e-03 2.246 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.793098e-03 2.237 1 0
Muscle contraction R-HSA-397014 5.927665e-03 2.227 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.092627e-03 2.215 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.150478e-03 2.211 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.171998e-03 2.210 0 0
Developmental Biology R-HSA-1266738 6.221631e-03 2.206 1 0
Signaling by EGFR in Cancer R-HSA-1643713 6.318832e-03 2.199 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.971835e-03 2.157 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.386143e-03 2.132 0 0
Unwinding of DNA R-HSA-176974 8.724114e-03 2.059 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.724114e-03 2.059 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 8.724114e-03 2.059 0 0
Interleukin-37 signaling R-HSA-9008059 8.700806e-03 2.060 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.248886e-03 2.084 0 0
Signaling by Interleukins R-HSA-449147 8.434848e-03 2.074 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.224603e-03 2.035 0 0
FOXO-mediated transcription R-HSA-9614085 9.454027e-03 2.024 0 0
rRNA processing R-HSA-72312 9.481589e-03 2.023 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.148454e-02 1.940 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.148454e-02 1.940 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.148454e-02 1.940 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.148454e-02 1.940 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.148454e-02 1.940 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.148454e-02 1.940 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.016191e-02 1.993 0 0
Signal attenuation R-HSA-74749 1.016191e-02 1.993 0 0
Integrin signaling R-HSA-354192 1.078863e-02 1.967 0 0
Regulation of CDH11 function R-HSA-9762292 1.016191e-02 1.993 0 0
IGF1R signaling cascade R-HSA-2428924 1.014448e-02 1.994 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.062591e-02 1.974 0 0
Cellular response to hypoxia R-HSA-1234174 1.062591e-02 1.974 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.078863e-02 1.967 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.016191e-02 1.993 0 0
Signaling by PTK6 R-HSA-8848021 9.677438e-03 2.014 1 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.677438e-03 2.014 1 0
Metabolism of RNA R-HSA-8953854 1.072275e-02 1.970 0 0
Signaling by Leptin R-HSA-2586552 1.016191e-02 1.993 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.015855e-02 1.993 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 1.154331e-02 1.938 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.157605e-02 1.936 1 1
PECAM1 interactions R-HSA-210990 1.169707e-02 1.932 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.169707e-02 1.932 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.169707e-02 1.932 0 0
Interleukin-2 signaling R-HSA-9020558 1.169707e-02 1.932 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.232769e-02 1.909 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.256193e-02 1.901 0 0
Signal Transduction R-HSA-162582 1.293289e-02 1.888 1 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.309430e-02 1.883 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.332721e-02 1.875 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.332721e-02 1.875 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.333667e-02 1.875 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.333667e-02 1.875 0 0
Interleukin-15 signaling R-HSA-8983432 1.504997e-02 1.822 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.504997e-02 1.822 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.398626e-02 1.854 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.501295e-02 1.824 0 0
Autophagy R-HSA-9612973 1.632937e-02 1.787 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.486074e-02 1.828 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.441116e-02 1.841 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.501295e-02 1.824 0 0
RNA Polymerase II Transcription R-HSA-73857 1.410273e-02 1.851 1 0
Generic Transcription Pathway R-HSA-212436 1.427964e-02 1.845 1 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 1.670069e-02 1.777 0 0
SARS-CoV Infections R-HSA-9679506 1.702126e-02 1.769 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.764533e-02 1.753 0 0
Interleukin-2 family signaling R-HSA-451927 1.766636e-02 1.753 0 0
Developmental Cell Lineages R-HSA-9734767 1.783710e-02 1.749 1 0
Cap-dependent Translation Initiation R-HSA-72737 1.817457e-02 1.741 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.817457e-02 1.741 0 0
L1CAM interactions R-HSA-373760 1.817457e-02 1.741 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.825901e-02 1.739 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.876409e-02 1.727 1 1
Signal regulatory protein family interactions R-HSA-391160 1.876409e-02 1.727 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.876409e-02 1.727 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.926427e-02 1.715 1 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.074694e-02 1.683 0 0
Erythropoietin activates RAS R-HSA-9027284 2.075094e-02 1.683 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.075094e-02 1.683 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.075094e-02 1.683 1 1
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.075094e-02 1.683 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.282137e-02 1.642 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.283790e-02 1.641 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.283790e-02 1.641 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.497322e-02 1.603 1 1
PI3K events in ERBB2 signaling R-HSA-1963642 2.720437e-02 1.565 1 1
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.720437e-02 1.565 0 0
Degradation of CDH1 R-HSA-9766229 2.900825e-02 1.537 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.953756e-02 1.530 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.047043e-02 1.516 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.495442e-02 1.603 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.495442e-02 1.603 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.497322e-02 1.603 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.410357e-02 1.618 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.951273e-02 1.530 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.574499e-02 1.589 1 0
Selective autophagy R-HSA-9663891 2.684204e-02 1.571 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.739832e-02 1.562 1 0
Signaling by VEGF R-HSA-194138 2.404997e-02 1.619 0 0
GPER1 signaling R-HSA-9634597 2.773620e-02 1.557 0 0
G1/S Transition R-HSA-69206 2.404997e-02 1.619 0 0
Signaling by Hippo R-HSA-2028269 2.720437e-02 1.565 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.951273e-02 1.530 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.497322e-02 1.603 0 0
Downstream TCR signaling R-HSA-202424 2.862190e-02 1.543 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.951273e-02 1.530 0 0
Influenza Infection R-HSA-168255 2.839820e-02 1.547 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.238799e-02 1.490 0 0
Orc1 removal from chromatin R-HSA-68949 3.300699e-02 1.481 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.300699e-02 1.481 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.337275e-02 1.477 1 1
PTEN Loss of Function in Cancer R-HSA-5674404 3.406154e-02 1.468 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.406154e-02 1.468 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.406154e-02 1.468 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.406154e-02 1.468 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.406154e-02 1.468 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.414320e-02 1.467 0 0
Signal transduction by L1 R-HSA-445144 3.435296e-02 1.464 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.437485e-02 1.464 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.437485e-02 1.464 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.440048e-02 1.463 0 0
Ribosome-associated quality control R-HSA-9948299 3.495073e-02 1.457 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.539434e-02 1.451 0 0
Eukaryotic Translation Termination R-HSA-72764 3.539434e-02 1.451 0 0
PTEN Regulation R-HSA-6807070 3.577001e-02 1.446 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 3.688083e-02 1.433 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.688083e-02 1.433 0 0
Macroautophagy R-HSA-1632852 3.744399e-02 1.427 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 3.947794e-02 1.404 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.947794e-02 1.404 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.947794e-02 1.404 0 0
Immune System R-HSA-168256 4.013337e-02 1.396 0 0
Regulation of CDH1 Function R-HSA-9764561 4.027432e-02 1.395 0 0
Glycolysis R-HSA-70171 4.075310e-02 1.390 0 0
Cell Cycle, Mitotic R-HSA-69278 4.096723e-02 1.388 0 0
Selenocysteine synthesis R-HSA-2408557 4.187718e-02 1.378 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 4.515696e-02 1.345 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 4.766584e-02 1.322 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 4.766584e-02 1.322 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 5.641036e-02 1.249 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.641036e-02 1.249 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.641036e-02 1.249 0 0
Signaling by Erythropoietin R-HSA-9006335 6.252596e-02 1.204 0 0
Late endosomal microautophagy R-HSA-9615710 6.252596e-02 1.204 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.252596e-02 1.204 0 0
Viral mRNA Translation R-HSA-192823 4.417769e-02 1.355 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.023385e-02 1.299 0 0
Activation of the pre-replicative complex R-HSA-68962 6.566451e-02 1.183 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.672344e-02 1.246 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.672344e-02 1.246 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 5.641036e-02 1.249 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.828071e-02 1.316 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.448318e-02 1.191 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.448318e-02 1.191 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.566451e-02 1.183 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.487230e-02 1.348 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.277787e-02 1.278 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 5.612561e-02 1.251 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.257285e-02 1.204 0 0
Diseases of Cellular Senescence R-HSA-9630747 4.515696e-02 1.345 0 0
Diseases of cellular response to stress R-HSA-9675132 4.515696e-02 1.345 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.535410e-02 1.343 0 0
TCR signaling R-HSA-202403 5.407582e-02 1.267 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.252596e-02 1.204 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.943973e-02 1.226 0 0
Synthesis of DNA R-HSA-69239 5.023385e-02 1.299 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.535410e-02 1.343 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.152262e-02 1.288 0 0
Membrane Trafficking R-HSA-199991 4.781909e-02 1.320 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.252596e-02 1.204 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.566451e-02 1.183 0 0
Signaling by NTRKs R-HSA-166520 4.461608e-02 1.351 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.849022e-02 1.314 0 0
Potential therapeutics for SARS R-HSA-9679191 4.652903e-02 1.332 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.641036e-02 1.249 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.641036e-02 1.249 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.023385e-02 1.299 0 0
Growth hormone receptor signaling R-HSA-982772 4.487230e-02 1.348 0 0
Signaling by ALK in cancer R-HSA-9700206 5.023385e-02 1.299 0 0
Viral Infection Pathways R-HSA-9824446 4.383787e-02 1.358 0 0
Gene expression (Transcription) R-HSA-74160 5.137891e-02 1.289 1 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 5.641036e-02 1.249 0 0
Glucose metabolism R-HSA-70326 6.652839e-02 1.177 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 6.696892e-02 1.174 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 6.696892e-02 1.174 1 1
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 6.696892e-02 1.174 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 6.696892e-02 1.174 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 6.696892e-02 1.174 0 0
Downstream signal transduction R-HSA-186763 6.885473e-02 1.162 0 0
Diseases of mitotic cell cycle R-HSA-9675126 7.209503e-02 1.142 0 0
DNA strand elongation R-HSA-69190 7.209503e-02 1.142 0 0
G0 and Early G1 R-HSA-1538133 7.209503e-02 1.142 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.538385e-02 1.123 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.538385e-02 1.123 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.538385e-02 1.123 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.538385e-02 1.123 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.538385e-02 1.123 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.558820e-02 1.122 1 1
Disease R-HSA-1643685 7.677215e-02 1.115 1 0
IRS activation R-HSA-74713 7.768833e-02 1.110 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 7.768833e-02 1.110 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 7.768833e-02 1.110 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 7.768833e-02 1.110 0 0
Integrin cell surface interactions R-HSA-216083 7.858969e-02 1.105 0 0
ESR-mediated signaling R-HSA-8939211 7.916170e-02 1.101 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.210099e-02 1.086 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.210099e-02 1.086 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.828524e-02 1.054 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 8.828524e-02 1.054 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 8.828524e-02 1.054 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 9.876105e-02 1.005 0 0
Erythropoietin activates STAT5 R-HSA-9027283 9.876105e-02 1.005 0 0
G2/M DNA replication checkpoint R-HSA-69478 9.876105e-02 1.005 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 9.876105e-02 1.005 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.091171e-01 0.962 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.091171e-01 0.962 0 0
Regulation of PTEN localization R-HSA-8948747 1.091171e-01 0.962 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.091171e-01 0.962 0 0
SOS-mediated signalling R-HSA-112412 1.091171e-01 0.962 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.091171e-01 0.962 0 0
Type I hemidesmosome assembly R-HSA-446107 1.193548e-01 0.923 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 1.193548e-01 0.923 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.193548e-01 0.923 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.193548e-01 0.923 0 0
Lipophagy R-HSA-9613354 1.294755e-01 0.888 0 0
CASP8 activity is inhibited R-HSA-5218900 1.294755e-01 0.888 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.394805e-01 0.855 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.493711e-01 0.826 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.591486e-01 0.798 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 1.591486e-01 0.798 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.591486e-01 0.798 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.552634e-02 1.068 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.295651e-01 0.888 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.295651e-01 0.888 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.531894e-01 0.815 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.572058e-01 0.804 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.022390e-01 0.990 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.106185e-01 0.956 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.295651e-01 0.888 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.295651e-01 0.888 0 0
PI3K/AKT activation R-HSA-198203 1.394805e-01 0.855 0 0
Signaling by RAS mutants R-HSA-6802949 1.295651e-01 0.888 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.605223e-02 1.017 0 0
Aggrephagy R-HSA-9646399 1.032639e-01 0.986 0 0
mRNA Splicing R-HSA-72172 1.193975e-01 0.923 0 0
PTK6 Expression R-HSA-8849473 1.091171e-01 0.962 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.193548e-01 0.923 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.591486e-01 0.798 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.250336e-02 1.034 0 0
MAP2K and MAPK activation R-HSA-5674135 1.106185e-01 0.956 0 0
Meiotic synapsis R-HSA-1221632 1.572058e-01 0.804 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.295651e-01 0.888 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 8.828524e-02 1.054 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 1.118093e-01 0.952 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.572058e-01 0.804 0 0
Regulation by c-FLIP R-HSA-3371378 1.193548e-01 0.923 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 1.394805e-01 0.855 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.394805e-01 0.855 0 0
vRNP Assembly R-HSA-192905 1.493711e-01 0.826 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.069240e-01 0.971 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.491939e-01 0.826 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.531894e-01 0.815 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.572058e-01 0.804 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 1.572058e-01 0.804 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.612419e-01 0.793 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.552634e-02 1.068 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.069240e-01 0.971 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 1.091171e-01 0.962 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.257167e-01 0.901 0 0
Signalling to ERKs R-HSA-187687 8.552634e-02 1.068 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 1.193548e-01 0.923 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.394805e-01 0.855 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.591486e-01 0.798 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 9.605223e-02 1.017 0 0
RET signaling R-HSA-8853659 8.899427e-02 1.051 0 0
Dimerization of procaspase-8 R-HSA-69416 1.193548e-01 0.923 0 0
ARMS-mediated activation R-HSA-170984 1.294755e-01 0.888 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.294755e-01 0.888 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 1.591486e-01 0.798 0 0
DNA Replication R-HSA-69306 1.374433e-01 0.862 0 0
Signaling by WNT R-HSA-195721 1.642025e-01 0.785 0 0
Somitogenesis R-HSA-9824272 1.257167e-01 0.901 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.552634e-02 1.068 0 0
Gastrulation R-HSA-9758941 1.293158e-01 0.888 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 9.876105e-02 1.005 0 0
WNT mediated activation of DVL R-HSA-201688 1.294755e-01 0.888 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.294755e-01 0.888 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.394805e-01 0.855 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.591486e-01 0.798 0 0
MTOR signalling R-HSA-165159 1.143463e-01 0.942 0 0
Diseases of DNA repair R-HSA-9675135 1.295651e-01 0.888 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 8.828524e-02 1.054 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 8.828524e-02 1.054 0 0
Nef and signal transduction R-HSA-164944 9.876105e-02 1.005 0 0
CHL1 interactions R-HSA-447041 1.091171e-01 0.962 0 0
Mitotic Prometaphase R-HSA-68877 1.007445e-01 0.997 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.257167e-01 0.901 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.257167e-01 0.901 0 0
S Phase R-HSA-69242 1.273164e-01 0.895 0 0
Generation of second messenger molecules R-HSA-202433 1.032639e-01 0.986 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.552634e-02 1.068 0 0
Innate Immune System R-HSA-168249 1.005759e-01 0.998 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.552634e-02 1.068 0 0
Vesicle-mediated transport R-HSA-5653656 1.008371e-01 0.996 0 0
Cilium Assembly R-HSA-5617833 9.632816e-02 1.016 0 0
Cellular response to starvation R-HSA-9711097 1.478849e-01 0.830 0 0
Co-inhibition by PD-1 R-HSA-389948 1.114366e-01 0.953 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.091171e-01 0.962 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.850467e-02 1.007 0 0
Complex IV assembly R-HSA-9864848 1.491939e-01 0.826 0 0
Signaling by FGFR4 R-HSA-5654743 1.181061e-01 0.928 0 0
Signaling by FGFR3 R-HSA-5654741 1.257167e-01 0.901 0 0
Infectious disease R-HSA-5663205 9.013265e-02 1.045 0 0
G1/S-Specific Transcription R-HSA-69205 8.899427e-02 1.051 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.181061e-01 0.928 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 9.963951e-02 1.002 0 0
Selenoamino acid metabolism R-HSA-2408522 1.608061e-01 0.794 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.605223e-02 1.017 0 0
Signaling by ROBO receptors R-HSA-376176 1.161814e-01 0.935 0 0
Dissolution of Fibrin Clot R-HSA-75205 1.493711e-01 0.826 0 0
Signaling by ALK R-HSA-201556 9.963951e-02 1.002 0 0
PI Metabolism R-HSA-1483255 1.435247e-01 0.843 0 0
Regulation of TP53 Activity R-HSA-5633007 1.521459e-01 0.818 0 0
Interleukin-1 family signaling R-HSA-446652 1.353922e-01 0.868 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.652969e-01 0.782 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.688144e-01 0.773 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.688144e-01 0.773 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.688144e-01 0.773 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.688144e-01 0.773 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.688144e-01 0.773 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.688144e-01 0.773 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.688144e-01 0.773 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.688144e-01 0.773 0 0
MET activates RAS signaling R-HSA-8851805 1.688144e-01 0.773 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.688144e-01 0.773 1 1
Signaling by EGFR R-HSA-177929 1.693698e-01 0.771 0 0
TNF signaling R-HSA-75893 1.693698e-01 0.771 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.693698e-01 0.771 0 0
Signaling by FGFR1 R-HSA-5654736 1.693698e-01 0.771 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.775655e-01 0.751 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.780860e-01 0.749 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.783696e-01 0.749 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.783696e-01 0.749 0 0
Frs2-mediated activation R-HSA-170968 1.783696e-01 0.749 0 0
Formation of axial mesoderm R-HSA-9796292 1.783696e-01 0.749 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.783696e-01 0.749 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.855054e-01 0.732 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.858218e-01 0.731 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.858218e-01 0.731 0 0
Prolactin receptor signaling R-HSA-1170546 1.878156e-01 0.726 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 1.878156e-01 0.726 0 0
Interferon Signaling R-HSA-913531 1.885443e-01 0.725 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.899704e-01 0.721 0 0
Signaling by PDGF R-HSA-186797 1.941316e-01 0.712 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.941316e-01 0.712 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.971535e-01 0.705 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.971535e-01 0.705 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.971535e-01 0.705 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.971535e-01 0.705 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.971535e-01 0.705 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.971535e-01 0.705 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.971535e-01 0.705 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.971535e-01 0.705 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.983045e-01 0.703 0 0
Bacterial Infection Pathways R-HSA-9824439 1.996251e-01 0.700 0 0
Insulin receptor signalling cascade R-HSA-74751 2.024883e-01 0.694 0 0
Ion transport by P-type ATPases R-HSA-936837 2.024883e-01 0.694 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.063847e-01 0.685 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.063847e-01 0.685 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 2.063847e-01 0.685 0 0
Phosphorylation of the APC/C R-HSA-176412 2.063847e-01 0.685 0 0
Prolonged ERK activation events R-HSA-169893 2.063847e-01 0.685 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.065724e-01 0.685 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.066822e-01 0.685 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.066822e-01 0.685 0 0
Deubiquitination R-HSA-5688426 2.139359e-01 0.670 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.150971e-01 0.667 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.155103e-01 0.667 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.155103e-01 0.667 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.155103e-01 0.667 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.155103e-01 0.667 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.155103e-01 0.667 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.155103e-01 0.667 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.159930e-01 0.666 0 0
Regulated Necrosis R-HSA-5218859 2.193167e-01 0.659 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.235434e-01 0.651 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.245315e-01 0.649 0 0
Glycogen storage diseases R-HSA-3229121 2.245315e-01 0.649 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.277764e-01 0.642 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.277764e-01 0.642 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.282957e-01 0.642 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.296861e-01 0.639 0 0
GAB1 signalosome R-HSA-180292 2.334495e-01 0.632 0 0
Platelet sensitization by LDL R-HSA-432142 2.334495e-01 0.632 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.334495e-01 0.632 0 0
Tie2 Signaling R-HSA-210993 2.334495e-01 0.632 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.362588e-01 0.627 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.362588e-01 0.627 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.422655e-01 0.616 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.422655e-01 0.616 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.422655e-01 0.616 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.422655e-01 0.616 0 0
Specification of the neural plate border R-HSA-9834899 2.422655e-01 0.616 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.422655e-01 0.616 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.422655e-01 0.616 0 0
Rap1 signalling R-HSA-392517 2.422655e-01 0.616 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.422655e-01 0.616 0 0
The NLRP3 inflammasome R-HSA-844456 2.422655e-01 0.616 0 0
Other interleukin signaling R-HSA-449836 2.422655e-01 0.616 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.422655e-01 0.616 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.447585e-01 0.611 0 0
Signaling by ERBB4 R-HSA-1236394 2.447585e-01 0.611 0 0
Circadian clock R-HSA-9909396 2.449277e-01 0.611 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 2.490132e-01 0.604 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.509806e-01 0.600 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.509806e-01 0.600 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.509806e-01 0.600 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.509806e-01 0.600 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.509806e-01 0.600 0 0
Glycogen synthesis R-HSA-3322077 2.509806e-01 0.600 0 0
Interleukin-12 signaling R-HSA-9020591 2.532703e-01 0.596 0 0
Signalling to RAS R-HSA-167044 2.595961e-01 0.586 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.603261e-01 0.584 0 0
G alpha (12/13) signalling events R-HSA-416482 2.617892e-01 0.582 0 0
PCP/CE pathway R-HSA-4086400 2.617892e-01 0.582 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.648613e-01 0.577 0 0
Translation R-HSA-72766 2.655272e-01 0.576 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.681130e-01 0.572 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.681130e-01 0.572 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.681130e-01 0.572 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.681130e-01 0.572 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.681130e-01 0.572 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.681130e-01 0.572 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.703106e-01 0.568 0 0
Signaling by MET R-HSA-6806834 2.703106e-01 0.568 0 0
Signaling by FGFR2 R-HSA-5654738 2.703106e-01 0.568 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.745707e-01 0.561 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 2.765324e-01 0.558 0 0
mTORC1-mediated signalling R-HSA-166208 2.765324e-01 0.558 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.765324e-01 0.558 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 2.765324e-01 0.558 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.788298e-01 0.555 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.820846e-01 0.550 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.829371e-01 0.548 0 0
Cytoprotection by HMOX1 R-HSA-9707564 2.830872e-01 0.548 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.848555e-01 0.545 0 0
Syndecan interactions R-HSA-3000170 2.848555e-01 0.545 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.848555e-01 0.545 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.848555e-01 0.545 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.852077e-01 0.545 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.915952e-01 0.535 0 0
Meiosis R-HSA-1500620 2.915952e-01 0.535 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.915952e-01 0.535 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 2.958448e-01 0.529 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.977271e-01 0.526 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.000906e-01 0.523 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.012170e-01 0.521 0 0
Long-term potentiation R-HSA-9620244 3.012170e-01 0.521 0 0
Formation of the nephric duct R-HSA-9830364 3.012170e-01 0.521 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 3.012170e-01 0.521 0 0
Interleukin-7 signaling R-HSA-1266695 3.012170e-01 0.521 0 0
Post NMDA receptor activation events R-HSA-438064 3.043324e-01 0.517 0 0
Interleukin-12 family signaling R-HSA-447115 3.043324e-01 0.517 0 0
Myogenesis R-HSA-525793 3.092576e-01 0.510 0 0
TRP channels R-HSA-3295583 3.092576e-01 0.510 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.092576e-01 0.510 0 0
Metalloprotease DUBs R-HSA-5689901 3.092576e-01 0.510 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.092576e-01 0.510 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.092576e-01 0.510 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.172062e-01 0.499 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.172062e-01 0.499 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.172062e-01 0.499 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 3.172062e-01 0.499 0 0
Death Receptor Signaling R-HSA-73887 3.197046e-01 0.495 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.212494e-01 0.493 0 0
M Phase R-HSA-68886 3.229626e-01 0.491 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 3.248145e-01 0.488 0 0
HIV elongation arrest and recovery R-HSA-167287 3.250637e-01 0.488 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.250637e-01 0.488 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.250637e-01 0.488 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.250637e-01 0.488 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.250637e-01 0.488 0 0
Inflammasomes R-HSA-622312 3.250637e-01 0.488 0 0
IRE1alpha activates chaperones R-HSA-381070 3.254639e-01 0.487 0 0
Signaling by Insulin receptor R-HSA-74752 3.296717e-01 0.482 0 0
EPH-Ephrin signaling R-HSA-2682334 3.296717e-01 0.482 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 3.328314e-01 0.478 0 0
DAP12 signaling R-HSA-2424491 3.405101e-01 0.468 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.405101e-01 0.468 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 3.405101e-01 0.468 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 3.405101e-01 0.468 0 0
EGFR downregulation R-HSA-182971 3.481009e-01 0.458 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.481009e-01 0.458 0 0
Molecules associated with elastic fibres R-HSA-2129379 3.481009e-01 0.458 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 3.481009e-01 0.458 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.481009e-01 0.458 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.505960e-01 0.455 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.547554e-01 0.450 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 3.556048e-01 0.449 0 0
Signaling by WNT in cancer R-HSA-4791275 3.556048e-01 0.449 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.567872e-01 0.448 0 0
Signaling by FGFR R-HSA-190236 3.589055e-01 0.445 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.630228e-01 0.440 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.630228e-01 0.440 0 0
Nuclear RNA decay R-HSA-9930044 3.630228e-01 0.440 0 0
Cardiogenesis R-HSA-9733709 3.630228e-01 0.440 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.703559e-01 0.431 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.703559e-01 0.431 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.754058e-01 0.425 0 0
G alpha (s) signalling events R-HSA-418555 3.761517e-01 0.425 0 0
RAF activation R-HSA-5673000 3.776050e-01 0.423 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.776050e-01 0.423 0 0
eNOS activation R-HSA-203615 3.776050e-01 0.423 0 0
Mitophagy R-HSA-5205647 3.776050e-01 0.423 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.776050e-01 0.423 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.776050e-01 0.423 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 3.776050e-01 0.423 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.776050e-01 0.423 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.792687e-01 0.421 0 0
Extracellular matrix organization R-HSA-1474244 3.818751e-01 0.418 0 0
Ub-specific processing proteases R-HSA-5689880 3.823824e-01 0.418 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.847710e-01 0.415 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.847710e-01 0.415 0 0
Regulation of Apoptosis R-HSA-169911 3.847710e-01 0.415 0 0
Oncogene Induced Senescence R-HSA-2559585 3.847710e-01 0.415 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.917319e-01 0.407 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.918550e-01 0.407 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.918550e-01 0.407 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.918550e-01 0.407 0 0
Respiratory electron transport R-HSA-611105 3.978971e-01 0.400 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.988579e-01 0.399 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 3.988579e-01 0.399 0 0
Degradation of DVL R-HSA-4641258 3.988579e-01 0.399 0 0
Degradation of AXIN R-HSA-4641257 3.988579e-01 0.399 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.988579e-01 0.399 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 4.057805e-01 0.392 0 0
Elastic fibre formation R-HSA-1566948 4.057805e-01 0.392 0 0
MET promotes cell motility R-HSA-8875878 4.057805e-01 0.392 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.118672e-01 0.385 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.118672e-01 0.385 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.126239e-01 0.384 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 4.126239e-01 0.384 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.126239e-01 0.384 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 4.126239e-01 0.384 0 0
Stabilization of p53 R-HSA-69541 4.126239e-01 0.384 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.126239e-01 0.384 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.193888e-01 0.377 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.193888e-01 0.377 0 0
HIV Transcription Elongation R-HSA-167169 4.193888e-01 0.377 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.193888e-01 0.377 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.193888e-01 0.377 0 0
Glycogen metabolism R-HSA-8982491 4.193888e-01 0.377 0 0
Inositol phosphate metabolism R-HSA-1483249 4.198302e-01 0.377 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.260763e-01 0.371 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.260763e-01 0.371 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.260763e-01 0.371 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.260763e-01 0.371 0 0
Cellular response to chemical stress R-HSA-9711123 4.261742e-01 0.370 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.277385e-01 0.369 0 0
Ion channel transport R-HSA-983712 4.316353e-01 0.365 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.326871e-01 0.364 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.326871e-01 0.364 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.326871e-01 0.364 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.326871e-01 0.364 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.326871e-01 0.364 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.326871e-01 0.364 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.392222e-01 0.357 0 0
Depyrimidination R-HSA-73928 4.392222e-01 0.357 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 4.392222e-01 0.357 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.415397e-01 0.355 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.456825e-01 0.351 0 0
TBC/RABGAPs R-HSA-8854214 4.456825e-01 0.351 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.456825e-01 0.351 0 0
Homology Directed Repair R-HSA-5693538 4.511187e-01 0.346 0 0
G1 Phase R-HSA-69236 4.520687e-01 0.345 0 0
Cyclin D associated events in G1 R-HSA-69231 4.520687e-01 0.345 0 0
DAP12 interactions R-HSA-2172127 4.520687e-01 0.345 0 0
Proteasome assembly R-HSA-9907900 4.520687e-01 0.345 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.520687e-01 0.345 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.549633e-01 0.342 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.583817e-01 0.339 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.583817e-01 0.339 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.583817e-01 0.339 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 4.626061e-01 0.335 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.646223e-01 0.333 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.646223e-01 0.333 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.646223e-01 0.333 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.646223e-01 0.333 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.646223e-01 0.333 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.705987e-01 0.327 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.707915e-01 0.327 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.707915e-01 0.327 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.707915e-01 0.327 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 4.720350e-01 0.326 0 0
Host Interactions of HIV factors R-HSA-162909 4.739525e-01 0.324 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 4.768899e-01 0.322 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.829184e-01 0.316 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.829184e-01 0.316 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.829184e-01 0.316 0 0
Platelet degranulation R-HSA-114608 4.888554e-01 0.311 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.888779e-01 0.311 0 0
PI3K Cascade R-HSA-109704 4.888779e-01 0.311 0 0
Meiotic recombination R-HSA-912446 4.947690e-01 0.306 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.947690e-01 0.306 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.947690e-01 0.306 0 0
mRNA 3'-end processing R-HSA-72187 5.005925e-01 0.301 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.005925e-01 0.301 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.005925e-01 0.301 0 0
Neurexins and neuroligins R-HSA-6794361 5.005925e-01 0.301 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.005925e-01 0.301 0 0
Reproduction R-HSA-1474165 5.034933e-01 0.298 0 0
Cardiac conduction R-HSA-5576891 5.071106e-01 0.295 0 0
Degradation of the extracellular matrix R-HSA-1474228 5.107108e-01 0.292 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.120401e-01 0.291 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.142939e-01 0.289 0 0
Signaling by NOTCH3 R-HSA-9012852 5.176656e-01 0.286 0 0
NRAGE signals death through JNK R-HSA-193648 5.232267e-01 0.281 0 0
Ion homeostasis R-HSA-5578775 5.232267e-01 0.281 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.284531e-01 0.277 0 0
IRS-mediated signalling R-HSA-112399 5.287239e-01 0.277 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.287239e-01 0.277 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.287239e-01 0.277 0 0
Unfolded Protein Response (UPR) R-HSA-381119 5.388887e-01 0.269 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.395300e-01 0.268 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.395300e-01 0.268 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 5.395300e-01 0.268 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 5.423320e-01 0.266 0 0
Leishmania phagocytosis R-HSA-9664417 5.423320e-01 0.266 0 0
Parasite infection R-HSA-9664407 5.423320e-01 0.266 0 0
HIV Infection R-HSA-162906 5.446336e-01 0.264 0 0
Metabolism of polyamines R-HSA-351202 5.448402e-01 0.264 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.500896e-01 0.260 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.500896e-01 0.260 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.500896e-01 0.260 0 0
Collagen degradation R-HSA-1442490 5.500896e-01 0.260 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.654790e-01 0.248 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.725169e-01 0.242 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.754466e-01 0.240 0 0
DNA Double Strand Break Response R-HSA-5693606 5.803448e-01 0.236 0 0
Kidney development R-HSA-9830369 5.803448e-01 0.236 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.822543e-01 0.235 0 0
Transcription of the HIV genome R-HSA-167172 5.851868e-01 0.233 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.854639e-01 0.232 0 0
Hemostasis R-HSA-109582 5.871897e-01 0.231 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.886554e-01 0.230 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.947047e-01 0.226 0 0
COPII-mediated vesicle transport R-HSA-204005 5.947047e-01 0.226 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.947047e-01 0.226 0 0
ECM proteoglycans R-HSA-3000178 5.993818e-01 0.222 0 0
Metabolism of cofactors R-HSA-8978934 5.993818e-01 0.222 0 0
Hedgehog 'on' state R-HSA-5632684 5.993818e-01 0.222 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 6.014563e-01 0.221 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.085757e-01 0.216 0 0
Ca2+ pathway R-HSA-4086398 6.085757e-01 0.216 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.085757e-01 0.216 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 6.085757e-01 0.216 0 0
Signaling by NOTCH4 R-HSA-9013694 6.130936e-01 0.212 0 0
Protein ubiquitination R-HSA-8852135 6.175597e-01 0.209 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.175597e-01 0.209 0 0
UCH proteinases R-HSA-5689603 6.219744e-01 0.206 0 0
ABC transporter disorders R-HSA-5619084 6.306525e-01 0.200 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.391324e-01 0.194 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.474186e-01 0.189 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.514905e-01 0.186 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.555156e-01 0.183 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 6.570629e-01 0.182 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.594944e-01 0.181 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 6.673155e-01 0.176 0 0
Cellular Senescence R-HSA-2559583 6.706802e-01 0.173 0 0
Pyruvate metabolism R-HSA-70268 6.711588e-01 0.173 0 0
Diseases of programmed cell death R-HSA-9645723 6.749579e-01 0.171 0 0
Leishmania infection R-HSA-9658195 6.774321e-01 0.169 0 0
Parasitic Infection Pathways R-HSA-9824443 6.774321e-01 0.169 0 0
ER-Phagosome pathway R-HSA-1236974 6.787133e-01 0.168 0 0
Neurotransmitter release cycle R-HSA-112310 6.824256e-01 0.166 0 0
Base Excision Repair R-HSA-73884 6.824256e-01 0.166 0 0
Protein folding R-HSA-391251 6.933085e-01 0.159 0 0
FCGR activation R-HSA-2029481 6.968530e-01 0.157 0 0
Toll-like Receptor Cascades R-HSA-168898 6.991040e-01 0.155 0 0
Collagen formation R-HSA-1474290 7.003568e-01 0.155 0 0
Phospholipid metabolism R-HSA-1483257 7.068184e-01 0.151 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.072440e-01 0.150 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 7.106283e-01 0.148 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.106283e-01 0.148 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.106283e-01 0.148 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.139737e-01 0.146 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 7.205495e-01 0.142 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.208301e-01 0.142 0 0
Hedgehog 'off' state R-HSA-5610787 7.237808e-01 0.140 0 0
ABC-family proteins mediated transport R-HSA-382556 7.237808e-01 0.140 0 0
Interleukin-1 signaling R-HSA-9020702 7.269750e-01 0.138 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.277744e-01 0.138 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.301324e-01 0.137 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.363386e-01 0.133 0 0
RSV-host interactions R-HSA-9833110 7.393883e-01 0.131 0 0
Platelet homeostasis R-HSA-418346 7.453828e-01 0.128 0 0
Gene Silencing by RNA R-HSA-211000 7.483285e-01 0.126 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 7.498781e-01 0.125 0 0
Stimuli-sensing channels R-HSA-2672351 7.512402e-01 0.124 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.512402e-01 0.124 0 0
Asparagine N-linked glycosylation R-HSA-446203 7.549530e-01 0.122 0 0
Mitotic Anaphase R-HSA-68882 7.582809e-01 0.120 0 0
Transmission across Chemical Synapses R-HSA-112315 7.594049e-01 0.120 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.603434e-01 0.119 0 0
FCERI mediated MAPK activation R-HSA-2871796 7.625558e-01 0.118 0 0
Neddylation R-HSA-8951664 7.684423e-01 0.114 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 7.759830e-01 0.110 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.759830e-01 0.110 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 7.782321e-01 0.109 0 0
Rab regulation of trafficking R-HSA-9007101 7.811399e-01 0.107 0 0
Peptide hormone metabolism R-HSA-2980736 7.811399e-01 0.107 0 0
Mitotic Prophase R-HSA-68875 7.886547e-01 0.103 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.911022e-01 0.102 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.911022e-01 0.102 0 0
Adaptive Immune System R-HSA-1280218 7.939397e-01 0.100 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 7.959128e-01 0.099 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.959128e-01 0.099 0 0
Signaling by NOTCH R-HSA-157118 8.037476e-01 0.095 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 8.052060e-01 0.094 0 0
DNA Repair R-HSA-73894 8.169736e-01 0.088 0 0
Sensory perception of taste R-HSA-9717189 8.183624e-01 0.087 0 0
Neuronal System R-HSA-112316 8.188463e-01 0.087 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.204676e-01 0.086 0 0
Signaling by Hedgehog R-HSA-5358351 8.345393e-01 0.079 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.439136e-01 0.074 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.475136e-01 0.072 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 8.578257e-01 0.067 0 0
Metabolism of amino acids and derivatives R-HSA-71291 8.642363e-01 0.063 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.653668e-01 0.063 0 0
HIV Life Cycle R-HSA-162587 8.689828e-01 0.061 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.705039e-01 0.060 0 0
Signaling by TGFB family members R-HSA-9006936 8.734936e-01 0.059 0 0
Separation of Sister Chromatids R-HSA-2467813 8.792686e-01 0.056 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.900437e-01 0.051 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.925845e-01 0.049 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.925845e-01 0.049 0 0
GPCR downstream signalling R-HSA-388396 9.008015e-01 0.045 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.149910e-01 0.039 0 0
HCMV Early Events R-HSA-9609690 9.179245e-01 0.037 0 0
Signaling by GPCR R-HSA-372790 9.430275e-01 0.025 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.487202e-01 0.023 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.553935e-01 0.020 0 0
HCMV Infection R-HSA-9609646 9.569380e-01 0.019 0 0
Post-translational protein modification R-HSA-597592 9.577426e-01 0.019 0 0
G alpha (q) signalling events R-HSA-416476 9.634712e-01 0.016 0 0
Metabolism of proteins R-HSA-392499 9.652116e-01 0.015 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.690177e-01 0.014 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.887702e-01 0.005 0 0
Diseases of metabolism R-HSA-5668914 9.947422e-01 0.002 0 0
Transport of small molecules R-HSA-382551 9.974320e-01 0.001 0 0
Biological oxidations R-HSA-211859 9.983253e-01 0.001 0 0
Metabolism R-HSA-1430728 9.999967e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999977e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999997e-01 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways