ALK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0	S1065	Sugiyama	POTEF A26C1B	ILASLSTFQQMWISKQEyDEsGPsIVHRKCL__________
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0	S939	Sugiyama	POTEF A26C1B	VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
O00170	T48	Sugiyama	AIP XAP2	FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF
O00299	S221	Sugiyama	CLIC1 G6 NCC27	EAFRGVHRYLsNAyAREEFAstCPDDEEIELAyEQVAKALK
O00299	T222	Sugiyama	CLIC1 G6 NCC27	AFRGVHRYLsNAyAREEFAstCPDDEEIELAyEQVAKALK_
O00505	S60	Sugiyama	KPNA3 QIP2	KRDEHLLKKRNVPQEEsLEDsDVDADFKAQNVTLEAILQNA
O00592	T556	Sugiyama	PODXL PCLP PCLP1	DsWIVPLDNLTKDDLDEEEDtHL__________________
O00625	S225	Sugiyama	PIR	PDDAQQKIEPHHTAVLGEGDsVQVENKDPKRSHFVLIAGEP
O15173	S208	Sugiyama	PGRMC2 DG6 PMBP	MQFKEKYDYVGRLLKPGEEPsEytDEEDtKDHNKQD_____
O15173	T211	Sugiyama	PGRMC2 DG6 PMBP	KEKYDYVGRLLKPGEEPsEytDEEDtKDHNKQD________
O15427	S464	Sugiyama	SLC16A3 MCT3 MCT4	EHFLKAEPEKNGEVVHtPEtsV___________________
O43719	S714	Sugiyama	HTATSF1	EKLFEDDDsNEKLFDEEEDssEKLFDDsDERGTLGGFGSVE
O43823	T681	Sugiyama	AKAP8 AKAP95	ESAQTRVAPAPAAADAEVEQtDAEsKDAVPTE_________
O43852	Y263	Sugiyama	CALU	KNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNKDG
O60220	S96	Sugiyama	TIMM8A DDP DDP1 TIM8A	FILNRLEQTQKSKPVFSEsLsD___________________
O60231	S106	Sugiyama	DHX16 DBP2 DDX16 KIAA0577 PRP2	EARALLEKNRSYRLLEDsEEssEEtVsRAGsSLQKKRKKRK
O60231	S319	Sugiyama	DHX16 DBP2 DDX16 KIAA0577 PRP2	HMPKETRGQPARAVDLVEEEsGAPGEEQRRWEEARLGAASL
O60664	S93	Sugiyama	PLIN3 M6PRBP1 TIP47	AAVsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQP
O60763	S952	Sugiyama	USO1 VDP	HPVEEEDELEsGDQEDEDDEsEDPGKDLDHI__________
O60841	S190	Sugiyama	EIF5B IF2 KIAA0741	NsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGP
O75533	T316	Sugiyama	SF3B1 SAP155	tPKtERDtPGHGsGWAEtPRtDRGGDsIGEtPtPGAsKRKs
O75822	S127	Sugiyama	EIF3J EIF3S1 PRO0391	VLtPEEQLADKLRLKKLQEEsDLELAKEtFGVNNAVyGIDA
O94992	S268	Sugiyama	HEXIM1 CLP1 EDG1 HIS1 MAQ1	EDGGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELI
O95218	S188	Sugiyama	ZRANB2 ZIS ZNF265	KLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRRSRSKSRS
O95218	T100	Sugiyama	ZRANB2 ZIS ZNF265	ARRsECNMCNtPKYAKLEERtGYGGGFNERENVEyIEREEs
O95757	S508	Sugiyama	HSPA4L APG1 HSPH3 OSP94	GIFSVASASVIEKQNLEGDHsDAPMETEtsFKNENKDNMDK
O95831	S118	Sugiyama	AIFM1 AIF PDCD8	RIsGLGLtPEQKQKKAALsAsEGEEVPQDKAPSHVPFLLIG
P00338	T220	Sugiyama	LDHA PIG19	VWSGMNVAGVSLKtLHPDLGtDKDKEQWKEVHKQVVEsAyE
P00558	S399	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558	T394	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P04075	S17	Sugiyama	ALDOA ALDA	____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083	S189	Sugiyama	ANXA1 ANX1 LPC1	tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04083	T169	Sugiyama	ANXA1 ANX1 LPC1	IRDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRs
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	T246	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05198	T284	Sugiyama	EIF2S1 EIF2A	EKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVDGDD
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05388	S304	Sugiyama	RPLP0	AttAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
P05388	S307	Sugiyama	RPLP0	AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
P05455	S83	Sugiyama	SSB	TDFNVIVEALSKSKAELMEIsEDKTKIRRsPsKPLPEVTDE
P05556	S503	Sugiyama	ITGB1 FNRB MDF2 MSK12	TFECGACRCNEGRVGRHCECstDEVNsEDMDAYCRKENSSE
P06733	S37	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	NPtVEVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRY
P06733	T100	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	KKLNVtEQEKIDKLMIEMDGtENKsKFGANAILGVsLAVCK
P06733	T205	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733	T41	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P07195	T18	Sugiyama	LDHB	___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07205	S399	Sugiyama	PGK2 PGKB	CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205	T394	Sugiyama	PGK2 PGKB	GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07237	S427	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07237	S88	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P07237	T335	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	VRLITLEEEMTKyKPEsEELtAERItEFCHRFLEGKIKPHL
P07237	T85	Sugiyama	P4HB ERBA2L PDI PDIA1 PO4DB	KAAGKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFF
P07437	T55	Sugiyama	TUBB TUBB5 OK/SW-cl.56	tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07814	S739	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07900	S165	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900	S263	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK
P07900	S391	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900	T195	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900	T305	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P08195	S598	Sugiyama	SLC3A2 MDU1	LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08238	S160	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238	S383	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238	S468	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238	S48	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238	T190	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238	T297	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238	T467	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238	Y301	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08670	S299	Sugiyama	VIM	VAAKNLQEAEEWyKSKFADLsEAANRNNDALRQAKQESTEY
P08708	S89	Sugiyama	RPS17 RPS17L	ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P09104	S37	Sugiyama	ENO2	NPtVEVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRY
P09104	T41	Sugiyama	ENO2	EVDLyTAKGLFRAAVPsGAstGIyEALELRDGDKQRYLGKG
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09874	S542	Sugiyama	PARP1 ADPRT PPOL	RMKLTLKGGAAVDPDsGLEHsAHVLEKGGKVFSATLGLVDI
P09972	T123	Sugiyama	ALDOC ALDC	IVVGIKVDKGVVPLAGtDGEtttQGLDGLsERCAQYKKDGA
P09972	T52	Sugiyama	ALDOC ALDC	AADEsVGsMAKRLsQIGVENtEENRRLYRQVLFsADDRVKK
P0CG38	S1065	Sugiyama	POTEI	ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1028	Sugiyama	POTEJ	ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P0DPH7	T51	Sugiyama	TUBA3C TUBA2	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P11142	T226	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P12643	S111	Sugiyama	BMP2 BMP2A	GSPAPDHRLERAASRANTVRsFHHEEsLEELPETSGKTTRR
P12643	S117	Sugiyama	BMP2 BMP2A	HRLERAASRANTVRsFHHEEsLEELPETSGKTTRRFFFNLS
P12956	S560	Sugiyama	XRCC6 G22P1	VtKRKHDNEGSGSKRPKVEysEEELKTHISKGTLGKFTVPM
P13489	S290	Sugiyama	RNH1 PRI RNH	AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13639	S587	Sugiyama	EEF2 EF2	CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13667	S468	Sugiyama	PDIA4 ERP70 ERP72	ytFAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAM
P13667	S470	Sugiyama	PDIA4 ERP70 ERP72	FAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAMEP
P13798	S185	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	VAEKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQ
P13804	S197	Sugiyama	ETFA	ATsGGsASsEKAsStsPVEIsEWLDQKLTKSDRPELTGAKV
P13929	S37	Sugiyama	ENO3	NPtVEVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRY
P13929	T41	Sugiyama	ENO3	EVDLHtAKGRFRAAVPsGAstGIyEALELRDGDKGRYLGKG
P14314	T103	Sugiyama	PRKCSH G19P1	KPLyIPSNRVNDGVCDCCDGtDEyNsGVICENtCKEKGRKE
P14625	S109	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625	T522	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	NRtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIyFMA
P15311	S539	Sugiyama	EZR VIL2	TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P17812	S574	Sugiyama	CTPS1 CTPS	YLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD___
P18669	T146	Sugiyama	PGAM1 PGAMA CDABP0006	MEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIARALPF
P19338	S619	Sugiyama	NCL	RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P19338	T583	Sugiyama	NCL	sPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARIVTD
P20042	S67	Sugiyama	EIF2S2 EIF2B	EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK
P20042	T33	Sugiyama	EIF2S2 EIF2B	sKKKKKKKKPFMLDEEGDtQtEEtQPsETKEVEPEPtEDKD
P20042	T36	Sugiyama	EIF2S2 EIF2B	KKKKKKPFMLDEEGDtQtEEtQPsETKEVEPEPtEDKDLEA
P20645	S267	Sugiyama	M6PR MPR46 MPRD	KPRNVPAAYRGVGDDQLGEEsEERDDHLLPM__________
P20810	S373	Sugiyama	CAST	LPEPEEKPKPRsEsELIDELsEDFDRsECKEKPSKPTEKTE
P22314	S46	Sugiyama	UBA1 A1S9T UBE1	AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P23528	T63	Sugiyama	CFL1 CFL	DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P25205	S704	Sugiyama	MCM3	DQEQKRKRRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPK
P25205	S711	Sugiyama	MCM3	RRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPKTADsQEt
P25205	Y708	Sugiyama	MCM3	KRKRRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPKTADs
P25705	S65	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	KtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARVH
P25788	S250	Sugiyama	PSMA3 HC8 PSC8	KDIREEAEKyAKEsLKEEDEsDDDNM_______________
P25788	Y239	Sugiyama	PSMA3 HC8 PSC8	ELTNGRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM____
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26196	S475	Sugiyama	DDX6 HLR2 RCK	TEIKPIPsNIDKSLyVAEyHsEPVEDEKP____________
P26639	T700	Sugiyama	TARS1 TARS	EKISGTVNIRTRDNKVHGERtIsEtIERLQQLKEFRSKQAE
P27348	S37	Sugiyama	YWHAQ	ERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKNVVGGRRS
P27695	T19	Sugiyama	APEX1 APE APE1 APEX APX HAP1 REF1	__MPKRGKKGAVAEDGDELRtEPEAKKSKTAAKKNDKEAAG
P27797	S195	Sugiyama	CALR CRTC	IVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIKDPDAsK
P27797	S214	Sugiyama	CALR CRTC	GsLEDDWDFLPPKKIKDPDAsKPEDWDERAKIDDPtDsKPE
P29692	S162	Sugiyama	EEF1D EF1D	AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692	S70	Sugiyama	EEF1D EF1D	IARARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVE
P29692	S71	Sugiyama	EEF1D EF1D	ARARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVEN
P29692	T73	Sugiyama	EEF1D EF1D	ARENIQKsLAGssGPGAssGtsGDHGELVVRIAsLEVENQs
P30041	T95	Sugiyama	PRDX6 AOP2 KIAA0106	SVEDHLAWSKDINAyNCEEPtEKLPFPIIDDRNRELAILLG
P30101	T485	Sugiyama	PDIA3 ERP57 ERP60 GRP58	KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P31946	S39	Sugiyama	YWHAB	ERyDDMAAAMKAVtEQGHELsNEERNLLsVAyKNVVGARRS
P33993	S314	Sugiyama	MCM7 CDC47 MCM2	SETyLEAHRIVKMNKSEDDEsGAGELtREELRQIAEEDFyE
P33993	T582	Sugiyama	MCM7 CDC47 MCM2	YIAMCREKQPMVPESLADYItAAYVEMRREAWASKDATyTS
P34932	S31	Sugiyama	HSPA4 APG2 HSPH2	QSCYVAVARAGGIETIANEysDRCtPACIsFGPKNRSIGAA
P34932	S415	Sugiyama	HSPA4 APG2 HSPH2	TDVVPYPISLRWNsPAEEGssDCEVFSKNHAAPFSKVLTFy
P35579	S169	Sugiyama	MYH9	HIyAITDtAyRSMMQDREDQsILCTGESGAGKTENTKKVIQ
P35579	T1904	Sugiyama	MYH9	EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35580	T1911	Sugiyama	MYH10	EEATRANASRRKLQRELDDAtEANEGLSREVSTLKNRLRRG
P35659	S231	Sugiyama	DEK	SGMARKAKRTKCPEILsDEsssDEDEKKNKEEssDDEDKEs
P36871	S477	Sugiyama	PGM1	KQFSANDKVYtVEKADNFEysDPVDGsIsRNQGLRLIFTDG
P36871	Y476	Sugiyama	PGM1	GKQFSANDKVYtVEKADNFEysDPVDGsIsRNQGLRLIFTD
P37802	T180	Sugiyama	TAGLN2 KIAA0120 CDABP0035	RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P41227	S216	Sugiyama	NAA10 ARD1 ARD1A TE2	EEKGLAAEDsGGDsKDLsEVsEtTEstDVKDssEAsDsAs_
P43121	T299	Sugiyama	MCAM MUC18	PPHFSISKQNPstREAEEEttNDNGVLVLEPARKEHSGRYE
P47756	T202	Sugiyama	CAPZB	SGsGtMNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMEN
P48643	S270	Sugiyama	CCT5 CCTE KIAA0098	ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ
P49327	S2198	Sugiyama	FASN FAS	EVRQLTLRKLQELSSKADEAsELACPtPKEDGLAQQQtQLN
P49589	S305	Sugiyama	CARS1 CARS	KLVPEAVGDQKALQEGEGDLsIsADRLsEKRSPNDFALWKA
P49736	T457	Sugiyama	MCM2 BM28 CCNL1 CDCL1 KIAA0030	TVILANHVAKKDNKVAVGELtDEDVKMITSLSKDQQIGEKI
P50502	S79	Sugiyama	ST13 AAG2 FAM10A1 HIP SNC6	KPDSKKVEEDLKADEPssEEsDLEIDKEGVIEPDTDAPQEM
P51114	S60	Sugiyama	FXR1	RQVPFNEVRLPPPPDIKKEIsEGDEVEVYSRANDQEPCGWW
P53618	T507	Sugiyama	COPB1 COPB MSTP026	PIVESEIKKEAGELKPEEEItVGPVQKLVTEMGtyAtQSAL
P54578	S492	Sugiyama	USP14 TGT	WHIAYVLLYGPRRVEIMEEEsEQ__________________
P54652	T229	Sugiyama	HSPA2	DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P55060	S366	Sugiyama	CSE1L CAS XPO2	KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P57721	S82	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK
P60660	T85	Sugiyama	MYL6	LDFEHFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVM
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S239	Sugiyama	ACTB	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709	S365	Sugiyama	ACTB	ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P61221	S218	Sugiyama	ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40	AIVCQQLDLTHLKERNVEDLsGGELQRFACAVVCIQKADIF
P61247	S236	Sugiyama	RPS3A FTE1 MFTL	KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247	S238	Sugiyama	RPS3A FTE1 MFTL	LKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyEP
P61247	S263	Sugiyama	RPS3A FTE1 MFTL	GDEtGAKVERADGyEPPVQEsV___________________
P61313	S100	Sugiyama	RPL15 EC45 TCBAP0781	tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61604	S21	Sugiyama	HSPE1	MAGQAFRKFLPLFDRVLVERsAAETVTKGGIMLPEKSQGKV
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	S38	Sugiyama	YWHAG	ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS
P61981	T31	Sugiyama	YWHAG	ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62269	T60	Sugiyama	RPS18 D6S218E	YAHVVLRKADIDLTKRAGELtEDEVERVItIMQNPRQYKIP
P62273	Y7	Sugiyama	RPS29	______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62495	S295	Sugiyama	ETF1 ERF1 RF1 SUP45L1	LSNVKFIQEKKLIGRyFDEIsQDtGKyCFGVEDTLKALEMG
P62736	S241	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	S37	Sugiyama	YWHAZ	ERyDDMAACMKsVtEQGAELsNEERNLLsVAyKNVVGARRs
P63104	Y211	Sugiyama	YWHAZ	LAKtAFDEAIAELDtLsEEsyKDstLIMQLLRDNLtLWtsD
P63167	S14	Sugiyama	DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1	_______MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNI
P63167	S21	Sugiyama	DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1	MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S239	Sugiyama	ACTG1 ACTG	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261	S365	Sugiyama	ACTG1 ACTG	ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63267	S240	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P67809	S313	Sugiyama	YBX1 NSEP1 YB1	ENPKPQDGKETKAADPPAENssAPEAEQGGAE_________
P67809	S314	Sugiyama	YBX1 NSEP1 YB1	NPKPQDGKETKAADPPAENssAPEAEQGGAE__________
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032	S241	Sugiyama	ACTC1 ACTC	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133	S241	Sugiyama	ACTA1 ACTA	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68363	T51	Sugiyama	TUBA1B	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P68363	T73	Sugiyama	TUBA1B	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363	T80	Sugiyama	TUBA1B	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q00341	S35	Sugiyama	HDLBP HBP VGL	HRSGLVPQQIKVAtLNsEEEsDPPtyKDAFPPLPEKAACLE
Q00796	S73	Sugiyama	SORD	EYGRIGNFIVKKPMVLGHEAsGtVEKVGSSVKHLKPGDRVA
Q00839	Y260	Sugiyama	HNRNPU C1orf199 HNRPU SAFA U21.1	GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01105	S161	Sugiyama	SET	FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105	S166	Sugiyama	SET	yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01581	S516	Sugiyama	HMGCS1 HMGCS	PAKKVPRLPAtAAEPEAAVIsNGEH________________
Q04637	S1430	Sugiyama	EIF4G1 EIF4F EIF4G EIF4GI	GQDIGAFVAEQKVEyTLGEEsEAPGQRALPsEELNRQLEKL
Q04917	S150	Sugiyama	YWHAH YWHA1	YYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQMQPTHP
Q07021	S210	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q07157	S1064	Sugiyama	TJP1 ZO1	PYVEKQAsRDLEQPtyRyEsssytDQFsRNYEHRLRYEDRV
Q09161	T27	Sugiyama	NCBP1 CBP80 NCBP	sDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKSACSLE
Q12792	T348	Sugiyama	TWF1 PTK9	GPAGKRGIRRLIRGPAEtEAttD__________________
Q12874	T131	Sugiyama	SF3A3 SAP61	EELLKARENPSEEAQNLVEFtDEEGyGRYLDLHDCYLKYIN
Q12906	T300	Sugiyama	ILF3 DRBF MPHOSPH4 NF90	ASGIVMPDGSGIYDPCEKEAtDAIGHLDRQQREDItQsAQH
Q13011	S43	Sugiyama	ECH1	NYPGLSISLRLtGssAQEEAsGVALGEAPDHSYESLRVTSA
Q13263	S479	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	ssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERLDLDLtA
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13283	T241	Sugiyama	G3BP1 G3BP	ETAPEDAQKsssPAPADIAQtVQEDLRtFsWAsVtsKNLPP
Q13428	S88	Sugiyama	TCOF1	DAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRLAst
Q13442	S63	Sugiyama	PDAP1 HASPP28	GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13601	S284	Sugiyama	KRR1 HRB2	KEYtPFPPPQPESQIDKELAsGEyFLKANQKKRQKMEAIKA
Q14137	S126	Sugiyama	BOP1 KIAA0124	tPCPRTEMASARIGDEyAEDssDEEDIRNTVGNVPLEWYDD
Q14152	S1188	Sugiyama	EIF3A EIF3S10 KIAA0139	PWRPLVKPGGWREKEKAREEsWGPPRESRPsEEREWDREKE
Q14152	S1256	Sugiyama	EIF3A EIF3S10 KIAA0139	EDRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRE
Q14152	S1257	Sugiyama	EIF3A EIF3S10 KIAA0139	DRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRER
Q14247	S432	Sugiyama	CTTN EMS1	EERLPssPVyEDAAsFKAELsyRGPVsGtEPEPVysMEAAD
Q14257	T137	Sugiyama	RCN2 ERC55	VTWDEyNIQMyDRVIDFDENtALDDAEEEsFRKLHLKDKKR
Q14566	T321	Sugiyama	MCM6	CCVAPTNPRFGGKELRDEEQtAEsIKNQMTVKEWEKVFEMs
Q14568	S165	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14677	S166	Sugiyama	CLINT1 ENTH EPN4 EPNR KIAA0171	REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q15056	T201	Sugiyama	EIF4H KIAA0038 WBSCR1 WSCR1	GSRFRDGPPLRGsNMDFREPtEEERAQRPRLQLKPRtVAtP
Q15185	S113	Sugiyama	PTGES3 P23 TEBP	RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15365	S50	Sugiyama	PCBP1	GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK
Q15366	S50	Sugiyama	PCBP2	GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK
Q15427	T14	Sugiyama	SF3B4 SAP49	_______MAAGPISERNQDAtVyVGGLDEKVSEPLLWELFL
Q15642	S298	Sugiyama	TRIP10 CIP4 STOT STP	RPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRT
Q15642	S299	Sugiyama	TRIP10 CIP4 STOT STP	PGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRSRTK
Q15797	S462	iPTMNet	SMAD1 BSP1 MADH1 MADR1	GPLQWLDKVLTQMGsPHNPIssVs_________________
Q15797	S463	SIGNOR\|iPTMNet	SMAD1 BSP1 MADH1 MADR1	PLQWLDKVLTQMGsPHNPIssVs__________________
Q15797	S465	SIGNOR\|iPTMNet	SMAD1 BSP1 MADH1 MADR1	QWLDKVLTQMGsPHNPIssVs____________________
Q16576	S163	Sugiyama	RBBP7 RBAP46	tPssDVLVFDyTKHPAKPDPsGECNPDLRLRGHQKEGYGLS
Q16576	T10	Sugiyama	RBBP7 RBAP46	___________MAsKEMFEDtVEERVINEEYKIWKKNTPFL
Q16637	S31	Sugiyama	SMN1 SMN SMNT; SMN2 SMNC	GVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVAsFK
Q2T9J0	S171	Sugiyama	TYSND1	FGDEAAEQWRFSSAARDDEVsEDEEADQLRALGWFALLGVR
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q562R1	S240	Sugiyama	ACTBL2	VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q58FF6	T165	Sugiyama	HSP90AB4P	DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7	T169	Sugiyama	HSP90AB3P HSP90BC	DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q5H9R7	S617	Sugiyama	PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3	NIALFEACCKERIQQFDDGGsDEEDIWEEKHIAFtPEsQRR
Q5T5C0	S700	Sugiyama	STXBP5 LLGL3	REPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKSPTSGSSsP
Q5T5C0	T703	Sugiyama	STXBP5 LLGL3	RSPRKsRQPsGAGLCDIsEGtVVPEDRCKSPTSGSSsPHNs
Q6NVY1	T368	Sugiyama	HIBCH	AVLIDKDQSPKWKPADLKEVtEEDLNNHFKSLGsSDLKF__
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PEY2	T51	Sugiyama	TUBA3E	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6S8J3	S1065	Sugiyama	POTEE A26C1A POTE2	ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3	S939	Sugiyama	POTEE A26C1A POTE2	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6UXH1	S295	Sugiyama	CRELD2 UNQ185/PRO211	KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q6YN16	T288	Sugiyama	HSDL2 C9orf99 SDR13C1	LQPDFFLDEYPEAVSKKVEstGAVPEFKEEKLQLQPKPRSG
Q71RC2	T424	Sugiyama	LARP4 PP13296	SSRNFPAERHNPTVTGHQEQtyLQKETSTLQVEQNGDYGRG
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36	T51	Sugiyama	TUBA1A TUBA3	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q71U36	T73	Sugiyama	TUBA1A TUBA3	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36	T80	Sugiyama	TUBA1A TUBA3	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q7Z4V5	S369	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	EKERRRERADRGEAERGsGGssGDELREDDEPVKKRGRKGR
Q8N392	S209	Sugiyama	ARHGAP18	TEsQSLRTNENKYQGRDDEAsNLVGEEKLIPPEETPAPETD
Q8NE71	S595	Sugiyama	ABCF1 ABC50	TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP
Q8NEY1	T1281	Sugiyama	NAV1 KIAA1151 KIAA1213 POMFIL3 STEERIN1	TEtAsPSIKsstsSSVGTDVtEGPAHPAPHTRLFHANEEEE
Q8NHW5	S304	Sugiyama	RPLP0P6	DTTAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
Q8NHW5	S307	Sugiyama	RPLP0P6	AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TDD1	S644	Sugiyama	DDX54	sRPALQEKQPEKEEEEEAGEsVEDIFSEVVGRKRQRSGPNR
Q8WU90	S231	Sugiyama	ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730	LPPGFVLKKDKKKEEKEDEIsLEDLIERERSALGPNVTKIT
Q92598	S509	Sugiyama	HSPH1 HSP105 HSP110 KIAA0201	IFTISTASMVEKVPtEENEMssEADMECLNQRPPENPDTDK
Q92769	S422	Sugiyama	HDAC2	PDKRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGA
Q92769	S424	Sugiyama	HDAC2	KRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGAKK
Q92890	S209	Sugiyama	UFD1 UFD1L	VDFDAPLGYKEPERQVQHEEstEGEADHsGyAGELGFRAFs
Q92890	T210	Sugiyama	UFD1 UFD1L	DFDAPLGYKEPERQVQHEEstEGEADHsGyAGELGFRAFsG
Q96C86	S24	Sugiyama	DCPS DCS1 HINT5 HSPC015	AAPQLGKRKRELDVEEAHAAstEEKEAGVGNGTCAPVRLPF
Q96C86	T25	Sugiyama	DCPS DCS1 HINT5 HSPC015	APQLGKRKRELDVEEAHAAstEEKEAGVGNGTCAPVRLPFS
Q96G46	T87	Sugiyama	DUS3L	LAEPEAKRIRLEDGQtADGQtEEAAEPGEQLQtQKRARGQN
Q96MH2	S194	Sugiyama	HEXIM2 L3	EAGDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELV
Q96QK1	S760	Sugiyama	VPS35 MEM3 TCCCTA00141	IQVLNQLIQKIREDLPNLEssEEtEQINKHFHNtLEHLRLR
Q96S66	Y68	Sugiyama	CLCC1 KIAA0761 MCLC	ISGEKDVSPDLsCADEIsECyHKLDSLTYKIDECEKKKRED
Q99613	S39	Sugiyama	EIF3C EIF3S8	GEELVTKPVGGNyGKQPLLLsEDEEDTKRVVRSAKDKRFEE
Q99733	S121	Sugiyama	NAP1L4 NAP2	PLFDKRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKV
Q99733	T117	Sugiyama	NAP1L4 NAP2	ALyQPLFDKRREFItGDVEPtDAEsEWHsENEEEEKLAGDM
Q99816	S299	Sugiyama	TSG101	QEVAEVDKNIELLKKKDEELssALEKMENQsENNDIDEVII
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BQE3	T51	Sugiyama	TUBA1C TUBA6	QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BQE3	T73	Sugiyama	TUBA1C TUBA6	FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3	T80	Sugiyama	TUBA1C TUBA6	KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BYX7	S239	Sugiyama	POTEKP ACTBL3 FKSG30	VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7	S365	Sugiyama	POTEKP ACTBL3 FKSG30	ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9C0C2	T1323	Sugiyama	TNKS1BP1 KIAA1741 TAB182	ELGVGQMDWGNNLGLRDLEVtCDPDsGGsQGLRGCGVGQMD
Q9H501	S312	Sugiyama	ESF1 ABTAP C20orf6 HDCMC28P	DDDKsDsGPDLARGKGNIEtssEDEDDtADLFPEESGFEHA
Q9HCC0	S256	Sugiyama	MCCC2 MCCB	QGTIFLAGPPLVKAATGEEVsAEDLGGADLHCRKSGVSDHW
Q9NR30	S121	Sugiyama	DDX21	PIEKKVVSSKTKKVTKNEEPsEEEIDAPKPKKMKKEKEMNG
Q9NRX4	T119	Sugiyama	PHPT1 PHP14 CGI-202 HSPC141	PAQHAISTEKIKAKyPDyEVtWANDGy______________
Q9NWX6	S298	Sugiyama	THG1L ICF45	HCDIIGDAFWKEHPEILDEDs____________________
Q9UHI6	S678	Sugiyama	DDX20 DP103 GEMIN3	SySSRTSSQSKGNKsyLEGssDNQLKDsEstPVDDRIsLEQ
Q9UI30	T123	Sugiyama	TRMT112 AD-001 HSPC152 HSPC170	SGRMFPISRGIPNMLLsEEEtEs__________________
Q9UPQ0	S201	Sugiyama	LIMCH1 KIAA1102	DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV
Q9UPR3	S475	Sugiyama	SMG5 EST1B KIAA1089	RLSCLRRRRHPPKVGDDSDLsEGFEsDSSHDSARASEGSDS
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7	T143	Sugiyama	YBX2 CSDA3 MSY2	QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y3F4	S312	Sugiyama	STRAP MAWD UNRIP	WQTVVGKtyGLWKCVLPEEDsGELAKPKIGFPETTEEELEE
Q9Y5S9	S56	Sugiyama	RBM8A RBM8 HSPC114 MDS014	KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	4.024699e-07	6.395
DNA Double-Strand Break Repair	R-HSA-5693532	8.975296e-06	5.047
mRNA Splicing - Major Pathway	R-HSA-72163	3.492410e-05	4.457
mRNA Splicing	R-HSA-72172	2.946968e-05	4.531
Chromatin organization	R-HSA-4839726	3.900835e-05	4.409
Metabolism of RNA	R-HSA-8953854	3.092714e-05	4.510
Chromatin modifying enzymes	R-HSA-3247509	3.611958e-05	4.442
DNA Repair	R-HSA-73894	6.800510e-05	4.167
MITF-M-dependent gene expression	R-HSA-9856651	6.092737e-05	4.215
Apoptotic cleavage of cellular proteins	R-HSA-111465	9.292205e-05	4.032
Regulation of MECP2 expression and activity	R-HSA-9022692	1.127133e-04	3.948
Cell Cycle	R-HSA-1640170	1.251435e-04	3.903
Formation of RNA Pol II elongation complex	R-HSA-112382	1.527885e-04	3.816
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.758476e-04	3.755
Epigenetic regulation of gene expression	R-HSA-212165	2.209496e-04	3.656
Apoptotic execution phase	R-HSA-75153	2.780329e-04	3.556
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.685643e-04	3.433
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	5.904139e-04	3.229
Signaling by Hippo	R-HSA-2028269	6.598768e-04	3.181
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	9.118087e-04	3.040
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	9.260905e-04	3.033
MECP2 regulates transcription factors	R-HSA-9022707	1.339975e-03	2.873
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.414385e-03	2.849
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.756822e-03	2.755
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.703124e-03	2.769
Homology Directed Repair	R-HSA-5693538	1.657102e-03	2.781
MITF-M-regulated melanocyte development	R-HSA-9730414	1.737129e-03	2.760
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.922110e-03	2.716
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.891718e-03	2.723
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.891718e-03	2.723
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	2.933420e-03	2.533
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.838825e-03	2.547
DNA Double Strand Break Response	R-HSA-5693606	3.157875e-03	2.501
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	3.271050e-03	2.485
Disorders of Developmental Biology	R-HSA-9675151	3.287970e-03	2.483
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	3.431752e-03	2.464
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	3.541489e-03	2.451
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	3.860347e-03	2.413
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	4.062945e-03	2.391
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	4.515957e-03	2.345
NoRC negatively regulates rRNA expression	R-HSA-427413	4.515957e-03	2.345
snRNP Assembly	R-HSA-191859	4.742363e-03	2.324
Metabolism of non-coding RNA	R-HSA-194441	4.742363e-03	2.324
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.493874e-03	2.187
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	7.064938e-03	2.151
Disorders of Nervous System Development	R-HSA-9697154	7.064938e-03	2.151
Pervasive developmental disorders	R-HSA-9005895	7.064938e-03	2.151
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	7.064938e-03	2.151
Cell Cycle Checkpoints	R-HSA-69620	6.709606e-03	2.173
ISG15 antiviral mechanism	R-HSA-1169408	6.296589e-03	2.201
G2/M Checkpoints	R-HSA-69481	7.809044e-03	2.107
PKMTs methylate histone lysines	R-HSA-3214841	7.943457e-03	2.100
Cap-dependent Translation Initiation	R-HSA-72737	9.083744e-03	2.042
Eukaryotic Translation Initiation	R-HSA-72613	9.083744e-03	2.042
DNA strand elongation	R-HSA-69190	9.462695e-03	2.024
RNA Polymerase I Transcription Initiation	R-HSA-73762	9.779421e-03	2.010
Nucleotide Excision Repair	R-HSA-5696398	9.914412e-03	2.004
Processing of DNA double-strand break ends	R-HSA-5693607	9.937602e-03	2.003
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.053041e-02	1.978
HDACs deacetylate histones	R-HSA-3214815	1.031176e-02	1.987
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.064441e-02	1.973
Activation of ATR in response to replication stress	R-HSA-176187	1.064441e-02	1.973
Notch-HLH transcription pathway	R-HSA-350054	1.066356e-02	1.972
Cell Cycle, Mitotic	R-HSA-69278	1.186168e-02	1.926
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.188877e-02	1.925
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.224455e-02	1.912
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.308793e-02	1.883
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.496852e-02	1.825
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.560597e-02	1.807
SWI/SNF chromatin remodelers	R-HSA-9932451	1.586755e-02	1.799
ATP-dependent chromatin remodelers	R-HSA-9932444	1.586755e-02	1.799
G2/M DNA damage checkpoint	R-HSA-69473	1.606579e-02	1.794
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.722089e-02	1.764
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.913568e-02	1.718
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.792088e-02	1.747
rRNA processing in the nucleus and cytosol	R-HSA-8868773	1.913516e-02	1.718
Unwinding of DNA	R-HSA-176974	1.913568e-02	1.718
Gene expression (Transcription)	R-HSA-74160	1.972364e-02	1.705
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.999473e-02	1.699
RNA Polymerase I Transcription Termination	R-HSA-73863	2.014233e-02	1.696
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.196530e-02	1.658
Transcriptional Regulation by MECP2	R-HSA-8986944	2.050841e-02	1.688
Regulation of TP53 Activity	R-HSA-5633007	2.184711e-02	1.661
Ephrin signaling	R-HSA-3928664	2.347328e-02	1.629
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.406279e-02	1.619
mRNA 3'-end processing	R-HSA-72187	2.379671e-02	1.623
Interactions of Rev with host cellular proteins	R-HSA-177243	2.406279e-02	1.619
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	2.317251e-02	1.635
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	2.352286e-02	1.629
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.347328e-02	1.629
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.570680e-02	1.590
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.578152e-02	1.589
Signaling by ALK in cancer	R-HSA-9700206	2.578152e-02	1.589
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.629021e-02	1.580
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	3.237365e-02	1.490
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.051728e-02	1.515
Ribosomal scanning and start codon recognition	R-HSA-72702	3.205831e-02	1.494
Signaling by EGFR	R-HSA-177929	3.205831e-02	1.494
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.163905e-02	1.500
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.339652e-02	1.476
NF-kB is activated and signals survival	R-HSA-209560	3.378836e-02	1.471
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.723343e-02	1.429
Dual incision in TC-NER	R-HSA-6782135	3.682982e-02	1.434
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	3.420437e-02	1.466
G0 and Early G1	R-HSA-1538133	3.392013e-02	1.470
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.723343e-02	1.429
Nuclear Envelope Breakdown	R-HSA-2980766	3.438915e-02	1.464
p75 NTR receptor-mediated signalling	R-HSA-193704	3.572276e-02	1.447
Deubiquitination	R-HSA-5688426	3.595710e-02	1.444
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	3.655215e-02	1.437
HIV Life Cycle	R-HSA-162587	3.765101e-02	1.424
Post NMDA receptor activation events	R-HSA-438064	3.819370e-02	1.418
Ub-specific processing proteases	R-HSA-5689880	3.831642e-02	1.417
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.867956e-02	1.413
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	3.867956e-02	1.413
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	4.073844e-02	1.390
Drug resistance of PDGFR mutants	R-HSA-9674415	4.544930e-02	1.342
PDGFR mutants bind TKIs	R-HSA-9674428	4.544930e-02	1.342
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	4.544930e-02	1.342
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	4.544930e-02	1.342
Imatinib-resistant PDGFR mutants	R-HSA-9674396	4.544930e-02	1.342
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	4.544930e-02	1.342
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.275576e-02	1.369
RNA Polymerase II Transcription Termination	R-HSA-73856	4.482604e-02	1.348
Transcriptional regulation by RUNX1	R-HSA-8878171	4.273535e-02	1.369
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.600731e-02	1.337
Heme signaling	R-HSA-9707616	4.772059e-02	1.321
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	4.797092e-02	1.319
IkBA variant leads to EDA-ID	R-HSA-5603029	5.419277e-02	1.266
Deadenylation of mRNA	R-HSA-429947	5.303909e-02	1.275
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	5.241737e-02	1.281
EPH-Ephrin signaling	R-HSA-2682334	5.210199e-02	1.283
RNA Polymerase III Transcription	R-HSA-74158	5.241737e-02	1.281
Regulation of TP53 Degradation	R-HSA-6804757	5.241737e-02	1.281
RNA Polymerase I Transcription	R-HSA-73864	5.066313e-02	1.295
rRNA modification in the nucleus and cytosol	R-HSA-6790901	5.073157e-02	1.295
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	5.066313e-02	1.295
Cellular response to heat stress	R-HSA-3371556	5.448238e-02	1.264
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	8.883559e-02	1.051
Diseases of Telomere Maintenance	R-HSA-9673013	8.883559e-02	1.051
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	8.883559e-02	1.051
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	8.883559e-02	1.051
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	8.883559e-02	1.051
CREB phosphorylation	R-HSA-199920	6.656762e-02	1.177
Recycling of eIF2:GDP	R-HSA-72731	7.977170e-02	1.098
Cohesin Loading onto Chromatin	R-HSA-2470946	7.977170e-02	1.098
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	6.010125e-02	1.221
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.781770e-02	1.169
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	8.450869e-02	1.073
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	6.990775e-02	1.155
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	6.990775e-02	1.155
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	7.607348e-02	1.119
Formation of the Early Elongation Complex	R-HSA-113418	7.607348e-02	1.119
HIV elongation arrest and recovery	R-HSA-167287	7.607348e-02	1.119
Pausing and recovery of HIV elongation	R-HSA-167290	7.607348e-02	1.119
Vpr-mediated nuclear import of PICs	R-HSA-180910	5.670067e-02	1.246
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	7.071956e-02	1.150
Golgi Associated Vesicle Biogenesis	R-HSA-432722	6.804233e-02	1.167
Translation initiation complex formation	R-HSA-72649	7.228065e-02	1.141
Post-translational protein phosphorylation	R-HSA-8957275	7.207740e-02	1.142
HIV Transcription Elongation	R-HSA-167169	7.071956e-02	1.150
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	7.071956e-02	1.150
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	6.585253e-02	1.181
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.895688e-02	1.161
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	5.936618e-02	1.226
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.585253e-02	1.181
Regulation of TP53 Expression and Degradation	R-HSA-6806003	6.585253e-02	1.181
Aggrephagy	R-HSA-9646399	7.071956e-02	1.150
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	5.742140e-02	1.241
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.316881e-02	1.080
HDR through Homologous Recombination (HRR)	R-HSA-5685942	6.395541e-02	1.194
p75NTR signals via NF-kB	R-HSA-193639	6.010125e-02	1.221
Activated NTRK3 signals through PI3K	R-HSA-9603381	7.977170e-02	1.098
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	6.401069e-02	1.194
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	8.536297e-02	1.069
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	8.250289e-02	1.084
Interactions of Vpr with host cellular proteins	R-HSA-176033	7.071956e-02	1.150
rRNA processing	R-HSA-72312	8.520059e-02	1.070
Resolution of Abasic Sites (AP sites)	R-HSA-73933	7.577899e-02	1.120
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.670067e-02	1.246
HDMs demethylate histones	R-HSA-3214842	5.838661e-02	1.234
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	8.536297e-02	1.069
MTOR signalling	R-HSA-165159	8.646777e-02	1.063
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.616657e-02	1.179
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	6.395245e-02	1.194
Constitutive Signaling by EGFRvIII	R-HSA-5637810	8.450869e-02	1.073
Signaling by EGFRvIII in Cancer	R-HSA-5637812	8.450869e-02	1.073
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	7.944451e-02	1.100
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	7.977170e-02	1.098
Signaling by ALK	R-HSA-201556	6.585253e-02	1.181
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.102909e-02	1.091
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	6.401069e-02	1.194
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	8.919036e-02	1.050
Activation of the pre-replicative complex	R-HSA-68962	8.919036e-02	1.050
DAP12 signaling	R-HSA-2424491	8.919036e-02	1.050
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.919036e-02	1.050
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	9.070643e-02	1.042
Defective SLC17A5 causes Salla disease (SD) and ISSD	R-HSA-5619035	1.302524e-01	0.885
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	1.302524e-01	0.885
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	1.302524e-01	0.885
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.697890e-01	0.770
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.697890e-01	0.770
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.697890e-01	0.770
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.697890e-01	0.770
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.697890e-01	0.770
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.697890e-01	0.770
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.697890e-01	0.770
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.697890e-01	0.770
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.697890e-01	0.770
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.697890e-01	0.770
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.697890e-01	0.770
Activated NTRK3 signals through PLCG1	R-HSA-9034793	2.075307e-01	0.683
PLC-gamma1 signalling	R-HSA-167021	2.075307e-01	0.683
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.075307e-01	0.683
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	2.075307e-01	0.683
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.075307e-01	0.683
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	2.075307e-01	0.683
Defective ABCD4 causes MAHCJ	R-HSA-5683329	2.075307e-01	0.683
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.075307e-01	0.683
Invadopodia formation	R-HSA-8941237	2.075307e-01	0.683
Alternative complement activation	R-HSA-173736	2.435588e-01	0.613
Activated NTRK2 signals through PLCG1	R-HSA-9026527	2.435588e-01	0.613
PLCG1 events in ERBB2 signaling	R-HSA-1251932	2.435588e-01	0.613
Inhibition of TSC complex formation by PKB	R-HSA-165181	2.435588e-01	0.613
2-LTR circle formation	R-HSA-164843	1.233887e-01	0.909
IRS activation	R-HSA-74713	2.779510e-01	0.556
FLT3 signaling by CBL mutants	R-HSA-9706377	2.779510e-01	0.556
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	9.344741e-02	1.029
RNA Polymerase III Transcription Termination	R-HSA-73980	9.344741e-02	1.029
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.027563e-01	0.988
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.712640e-01	0.766
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.712640e-01	0.766
Leading Strand Synthesis	R-HSA-69109	1.712640e-01	0.766
Polymerase switching	R-HSA-69091	1.712640e-01	0.766
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	3.107816e-01	0.508
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	1.878371e-01	0.726
Lagging Strand Synthesis	R-HSA-69186	1.224051e-01	0.912
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	1.327043e-01	0.877
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.327043e-01	0.877
Autointegration results in viral DNA circles	R-HSA-177539	3.421213e-01	0.466
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	3.421213e-01	0.466
Defective CHST3 causes SEDCJD	R-HSA-3595172	3.421213e-01	0.466
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	R-HSA-5619070	3.421213e-01	0.466
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	3.421213e-01	0.466
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	9.612968e-02	1.017
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	9.612968e-02	1.017
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	1.432926e-01	0.844
Spry regulation of FGF signaling	R-HSA-1295596	2.215515e-01	0.655
Processive synthesis on the lagging strand	R-HSA-69183	2.215515e-01	0.655
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	2.215515e-01	0.655
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	2.215515e-01	0.655
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.215515e-01	0.655
RNA Polymerase III Chain Elongation	R-HSA-73780	2.215515e-01	0.655
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	1.541493e-01	0.812
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	1.541493e-01	0.812
IPs transport between nucleus and cytosol	R-HSA-1855170	1.107365e-01	0.956
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.385913e-01	0.622
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.720377e-01	0.429
SOS-mediated signalling	R-HSA-112412	3.720377e-01	0.429
Defective CHSY1 causes TPBS	R-HSA-3595177	3.720377e-01	0.429
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.343525e-01	0.872
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.556921e-01	0.592
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.038893e-01	0.983
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.100548e-01	0.958
mRNA Splicing - Minor Pathway	R-HSA-72165	1.100548e-01	0.958
EPHA-mediated growth cone collapse	R-HSA-3928663	1.998501e-01	0.699
EGFR interacts with phospholipase C-gamma	R-HSA-212718	4.005955e-01	0.397
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	4.005955e-01	0.397
Activated NTRK2 signals through PI3K	R-HSA-9028335	4.005955e-01	0.397
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.007884e-01	0.997
Activation of AMPK downstream of NMDARs	R-HSA-9619483	2.117436e-01	0.674
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.237856e-01	0.650
Regulation of signaling by CBL	R-HSA-912631	3.069711e-01	0.513
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.069711e-01	0.513
ARMS-mediated activation	R-HSA-170984	4.278562e-01	0.369
WNT mediated activation of DVL	R-HSA-201688	4.278562e-01	0.369
ALK mutants bind TKIs	R-HSA-9700645	4.278562e-01	0.369
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.239435e-01	0.490
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.239435e-01	0.490
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.239435e-01	0.490
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.239435e-01	0.490
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.538787e-01	0.343
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.538787e-01	0.343
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.855877e-01	0.544
Striated Muscle Contraction	R-HSA-390522	2.855877e-01	0.544
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	2.547746e-01	0.594
FGFR2 alternative splicing	R-HSA-6803529	3.741080e-01	0.427
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	3.905031e-01	0.408
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.067029e-01	0.391
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.898369e-01	0.538
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.226913e-01	0.374
Amplification of signal from the kinetochores	R-HSA-141424	2.751019e-01	0.561
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.751019e-01	0.561
MET activates PTK2 signaling	R-HSA-8874081	4.384540e-01	0.358
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	3.985352e-01	0.400
HIV Transcription Initiation	R-HSA-167161	3.985352e-01	0.400
RNA Polymerase II Transcription Initiation	R-HSA-75953	3.985352e-01	0.400
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.684479e-01	0.434
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	3.310165e-01	0.480
RNA Polymerase II Promoter Escape	R-HSA-73776	4.231576e-01	0.373
Formation of a pool of free 40S subunits	R-HSA-72689	3.717853e-01	0.430
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	4.474257e-01	0.349
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.474257e-01	0.349
Nucleosome assembly	R-HSA-774815	4.474257e-01	0.349
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.562841e-01	0.448
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.562841e-01	0.448
Transcription of the HIV genome	R-HSA-167172	2.809690e-01	0.551
EGFR downregulation	R-HSA-182971	2.482408e-01	0.605
Downstream signal transduction	R-HSA-186763	9.612968e-02	1.017
Signaling by PDGFR in disease	R-HSA-9671555	1.327043e-01	0.877
mRNA Capping	R-HSA-72086	2.237856e-01	0.650
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	2.359574e-01	0.627
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	4.526435e-01	0.344
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	3.148565e-01	0.502
Integration of provirus	R-HSA-162592	1.549556e-01	0.810
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	3.861142e-01	0.413
Asymmetric localization of PCP proteins	R-HSA-4608870	4.474257e-01	0.349
Ribosome-associated quality control	R-HSA-9948299	4.326238e-01	0.364
Integrin signaling	R-HSA-354192	2.730727e-01	0.564
Apoptosis induced DNA fragmentation	R-HSA-140342	4.538787e-01	0.343
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	4.067029e-01	0.391
PI3K/AKT activation	R-HSA-198203	1.233887e-01	0.909
Activation of C3 and C5	R-HSA-174577	2.779510e-01	0.556
Eukaryotic Translation Termination	R-HSA-72764	3.717853e-01	0.430
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.998501e-01	0.699
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.348225e-01	0.629
Resolution of D-Loop Structures	R-HSA-5693537	1.183890e-01	0.927
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.271995e-01	0.644
EPHB-mediated forward signaling	R-HSA-3928662	4.353403e-01	0.361
Generation of second messenger molecules	R-HSA-202433	3.736335e-01	0.428
Regulation of gap junction activity	R-HSA-191650	2.435588e-01	0.613
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	1.327043e-01	0.877
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	1.107365e-01	0.956
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.556921e-01	0.592
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	1.776910e-01	0.750
Translesion Synthesis by POLH	R-HSA-110320	3.069711e-01	0.513
IRS-related events triggered by IGF1R	R-HSA-2428928	3.996725e-01	0.398
Separation of Sister Chromatids	R-HSA-2467813	3.421385e-01	0.466
Signaling by PDGF	R-HSA-186797	2.291203e-01	0.640
Repression of WNT target genes	R-HSA-4641265	1.712640e-01	0.766
Long-term potentiation	R-HSA-9620244	1.765854e-01	0.753
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.899175e-01	0.538
PKA-mediated phosphorylation of CREB	R-HSA-111931	3.408068e-01	0.467
Mitotic Spindle Checkpoint	R-HSA-69618	2.615734e-01	0.582
Chromosome Maintenance	R-HSA-73886	1.820805e-01	0.740
Mitotic Prometaphase	R-HSA-68877	1.941251e-01	0.712
Late Phase of HIV Life Cycle	R-HSA-162599	1.317634e-01	0.880
Extension of Telomeres	R-HSA-180786	3.788759e-01	0.422
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.827375e-01	0.549
Telomere Maintenance	R-HSA-157579	3.881605e-01	0.411
Formation of the posterior neural plate	R-HSA-9832991	1.389745e-01	0.857
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	2.779510e-01	0.556
Activation of AKT2	R-HSA-165158	2.779510e-01	0.556
PTK6 Expression	R-HSA-8849473	3.720377e-01	0.429
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.295749e-01	0.887
Negative regulation of MET activity	R-HSA-6807004	3.239435e-01	0.490
Post-chaperonin tubulin folding pathway	R-HSA-389977	3.239435e-01	0.490
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.730727e-01	0.564
Mitochondrial biogenesis	R-HSA-1592230	1.617050e-01	0.791
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.226913e-01	0.374
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	3.985352e-01	0.400
Eukaryotic Translation Elongation	R-HSA-156842	3.391359e-01	0.470
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.465805e-01	0.834
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.007884e-01	0.997
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.007884e-01	0.997
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.007884e-01	0.997
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.007884e-01	0.997
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.820805e-01	0.740
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.881242e-01	0.726
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	1.432926e-01	0.844
RUNX3 regulates WNT signaling	R-HSA-8951430	3.720377e-01	0.429
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.006766e-01	0.997
Transcriptional regulation by small RNAs	R-HSA-5578749	1.724704e-01	0.763
Formation of Incision Complex in GG-NER	R-HSA-5696395	3.736335e-01	0.428
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	3.736335e-01	0.428
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	4.384540e-01	0.358
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.359574e-01	0.627
Signaling by NOTCH3	R-HSA-9012852	3.371310e-01	0.472
Synthesis of DNA	R-HSA-69239	3.192074e-01	0.496
Signaling by ERBB2 KD Mutants	R-HSA-9664565	2.237856e-01	0.650
Signaling by FGFR2	R-HSA-5654738	2.291947e-01	0.640
MET promotes cell motility	R-HSA-8875878	3.485371e-01	0.458
TCR signaling	R-HSA-202403	2.119119e-01	0.674
Translation	R-HSA-72766	4.362296e-01	0.360
Signaling by FGFR4	R-HSA-5654743	2.152731e-01	0.667
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	2.359574e-01	0.627
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.278562e-01	0.369
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.981473e-01	0.526
Signaling by FGFR3	R-HSA-5654741	2.348225e-01	0.629
Signaling by ERBB2 ECD mutants	R-HSA-9665348	9.344741e-02	1.029
IGF1R signaling cascade	R-HSA-2428924	4.306200e-01	0.366
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	2.435588e-01	0.613
AKT-mediated inactivation of FOXO1A	R-HSA-211163	2.435588e-01	0.613
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	1.549556e-01	0.810
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.549556e-01	0.810
PDE3B signalling	R-HSA-165160	3.107816e-01	0.508
PKB-mediated events	R-HSA-109703	3.107816e-01	0.508
Noncanonical activation of NOTCH3	R-HSA-9017802	3.107816e-01	0.508
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.878371e-01	0.726
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.878371e-01	0.726
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	1.327043e-01	0.877
mTORC1-mediated signalling	R-HSA-166208	1.432926e-01	0.844
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	2.215515e-01	0.655
Class I peroxisomal membrane protein import	R-HSA-9603798	2.385913e-01	0.622
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.728132e-01	0.564
Co-stimulation by ICOS	R-HSA-9927354	4.005955e-01	0.397
Viral Messenger RNA Synthesis	R-HSA-168325	1.060417e-01	0.975
Signaling by FGFR2 IIIa TM	R-HSA-8851708	3.069711e-01	0.513
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.538787e-01	0.343
Deadenylation-dependent mRNA decay	R-HSA-429914	2.043345e-01	0.690
Signaling by NOTCH2	R-HSA-1980145	2.981473e-01	0.526
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.981473e-01	0.526
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	4.067029e-01	0.391
TRAF6 mediated NF-kB activation	R-HSA-933542	4.067029e-01	0.391
Myogenesis	R-HSA-525793	4.384540e-01	0.358
Signaling by FGFR1	R-HSA-5654736	3.475681e-01	0.459
Chaperone Mediated Autophagy	R-HSA-9613829	2.899175e-01	0.538
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.408453e-01	0.356
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.792215e-01	0.747
Organelle biogenesis and maintenance	R-HSA-1852241	3.222597e-01	0.492
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.067029e-01	0.391
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	3.167123e-01	0.499
Extra-nuclear estrogen signaling	R-HSA-9009391	4.208681e-01	0.376
Signaling by FGFR1 in disease	R-HSA-5655302	3.985352e-01	0.400
HIV Infection	R-HSA-162906	2.646588e-01	0.577
Mitotic Anaphase	R-HSA-68882	3.079688e-01	0.511
Regulation of CDH11 gene transcription	R-HSA-9762293	1.082721e-01	0.965
ERK/MAPK targets	R-HSA-198753	1.224051e-01	0.912
NRIF signals cell death from the nucleus	R-HSA-205043	2.046173e-01	0.689
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.107365e-01	0.956
Signal attenuation	R-HSA-74749	4.538787e-01	0.343
M Phase	R-HSA-68886	1.342518e-01	0.872
DAP12 interactions	R-HSA-2172127	2.249927e-01	0.648
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.130897e-01	0.504
Signaling by FGFR	R-HSA-190236	3.963479e-01	0.402
S Phase	R-HSA-69242	1.563452e-01	0.806
Regulated proteolysis of p75NTR	R-HSA-193692	1.082721e-01	0.965
Muscarinic acetylcholine receptors	R-HSA-390648	2.779510e-01	0.556
Signaling by LTK	R-HSA-9842663	1.712640e-01	0.766
Signaling by FGFR4 in disease	R-HSA-5655291	2.046173e-01	0.689
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.183890e-01	0.927
MET activates PI3K/AKT signaling	R-HSA-8851907	3.720377e-01	0.429
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.100548e-01	0.958
MET activates RAP1 and RAC1	R-HSA-8875555	4.538787e-01	0.343
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	3.485371e-01	0.458
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.059337e-01	0.686
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.554904e-01	0.593
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.343525e-01	0.872
Signaling by NOTCH1	R-HSA-1980143	2.000867e-01	0.699
Autophagy	R-HSA-9612973	4.205397e-01	0.376
Netrin-1 signaling	R-HSA-373752	4.353403e-01	0.361
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	4.237061e-01	0.373
Cellular Senescence	R-HSA-2559583	4.465022e-01	0.350
Acyl chain remodelling of PS	R-HSA-1482801	1.765854e-01	0.753
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	4.452552e-01	0.351
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	4.237061e-01	0.373
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.460944e-01	0.351
Membrane Trafficking	R-HSA-199991	3.900072e-01	0.409
RMTs methylate histone arginines	R-HSA-3214858	9.790082e-02	1.009
CD209 (DC-SIGN) signaling	R-HSA-5621575	4.067029e-01	0.391
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.683933e-01	0.434
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.460944e-01	0.351
Signaling by VEGF	R-HSA-194138	3.286593e-01	0.483
Diseases associated with the TLR signaling cascade	R-HSA-5602358	3.736335e-01	0.428
Diseases of Immune System	R-HSA-5260271	3.736335e-01	0.428
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.877206e-01	0.726
Macroautophagy	R-HSA-1632852	3.169826e-01	0.499
Signaling by FGFR in disease	R-HSA-1226099	3.347995e-01	0.475
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.224051e-01	0.912
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.224051e-01	0.912
Calmodulin induced events	R-HSA-111933	1.426462e-01	0.846
Signaling by ERBB2	R-HSA-1227986	3.892864e-01	0.410
MAP kinase activation	R-HSA-450294	3.996725e-01	0.398
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.138482e-01	0.383
Breakdown of the nuclear lamina	R-HSA-352238	1.302524e-01	0.885
Depolymerization of the Nuclear Lamina	R-HSA-4419969	9.344741e-02	1.029
Early Phase of HIV Life Cycle	R-HSA-162594	1.224051e-01	0.912
Integration of viral DNA into host genomic DNA	R-HSA-175567	3.421213e-01	0.466
Ca2+ activated K+ channels	R-HSA-1296052	3.720377e-01	0.429
Signaling by EGFR in Cancer	R-HSA-1643713	1.881242e-01	0.726
CaM pathway	R-HSA-111997	1.426462e-01	0.846
TGFBR3 PTM regulation	R-HSA-9839383	4.005955e-01	0.397
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.007884e-01	0.997
Transcriptional Regulation by E2F6	R-HSA-8953750	1.686680e-01	0.773
Transport of connexons to the plasma membrane	R-HSA-190872	2.899175e-01	0.538
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	4.278562e-01	0.369
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	1.200340e-01	0.921
PI3K/AKT Signaling in Cancer	R-HSA-2219528	9.301115e-02	1.031
Signaling by MET	R-HSA-6806834	2.291947e-01	0.640
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.861142e-01	0.413
Metalloprotease DUBs	R-HSA-5689901	4.384540e-01	0.358
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.900578e-01	0.538
Circadian clock	R-HSA-9909396	3.839167e-01	0.416
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.413891e-01	0.467
DAG and IP3 signaling	R-HSA-1489509	1.038893e-01	0.983
MyD88-independent TLR4 cascade	R-HSA-166166	3.413891e-01	0.467
Intracellular signaling by second messengers	R-HSA-9006925	1.810360e-01	0.742
PIP3 activates AKT signaling	R-HSA-1257604	3.016006e-01	0.521
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.045616e-01	0.516
Signaling by NTRK3 (TRKC)	R-HSA-9034015	1.327043e-01	0.877
Axon guidance	R-HSA-422475	3.241308e-01	0.489
Response of endothelial cells to shear stress	R-HSA-9860931	1.715685e-01	0.766
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.492618e-01	0.457
Pexophagy	R-HSA-9664873	4.538787e-01	0.343
Selective autophagy	R-HSA-9663891	2.988279e-01	0.525
Nervous system development	R-HSA-9675108	3.103034e-01	0.508
Uptake and function of anthrax toxins	R-HSA-5210891	2.728132e-01	0.564
Ca-dependent events	R-HSA-111996	2.056735e-01	0.687
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.257426e-01	0.487
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.421213e-01	0.466
Nuclear import of Rev protein	R-HSA-180746	1.262638e-01	0.899
Kinesins	R-HSA-983189	1.007884e-01	0.997
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	4.278562e-01	0.369
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.107364e-01	0.508
RNA Polymerase II Transcription	R-HSA-73857	2.110060e-01	0.676
Cellular responses to mechanical stimuli	R-HSA-9855142	1.378847e-01	0.860
Golgi-to-ER retrograde transport	R-HSA-8856688	3.839167e-01	0.416
GAB1 signalosome	R-HSA-180292	2.899175e-01	0.538
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.339487e-01	0.631
FLT3 signaling in disease	R-HSA-9682385	1.426462e-01	0.846
Regulation of PTEN gene transcription	R-HSA-8943724	1.007884e-01	0.997
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.107365e-01	0.956
Bicarbonate transporters	R-HSA-425381	1.389745e-01	0.857
CLEC7A/inflammasome pathway	R-HSA-5660668	3.107816e-01	0.508
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.124156e-01	0.949
Signaling by LTK in cancer	R-HSA-9842640	3.421213e-01	0.466
Cation-coupled Chloride cotransporters	R-HSA-426117	3.720377e-01	0.429
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.005955e-01	0.397
Sodium/Proton exchangers	R-HSA-425986	4.005955e-01	0.397
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.868727e-01	0.728
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	4.278562e-01	0.369
Signaling by FGFR2 in disease	R-HSA-5655253	2.852931e-01	0.545
Smooth Muscle Contraction	R-HSA-445355	3.163018e-01	0.500
PLC beta mediated events	R-HSA-112043	3.996725e-01	0.398
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.239569e-01	0.490
ESR-mediated signaling	R-HSA-8939211	3.127121e-01	0.505
Mitotic Prophase	R-HSA-68875	9.998845e-02	1.000
Nuclear signaling by ERBB4	R-HSA-1251985	3.736335e-01	0.428
Regulation of endogenous retroelements	R-HSA-9842860	2.757202e-01	0.560
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.479055e-01	0.830
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.033141e-01	0.986
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	2.728132e-01	0.564
Maternal to zygotic transition (MZT)	R-HSA-9816359	3.082771e-01	0.511
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	1.424959e-01	0.846
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	1.697890e-01	0.770
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	2.779510e-01	0.556
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.549556e-01	0.810
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	3.107816e-01	0.508
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	1.878371e-01	0.726
Formation of the anterior neural plate	R-HSA-9823739	2.215515e-01	0.655
CHL1 interactions	R-HSA-447041	3.720377e-01	0.429
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	2.728132e-01	0.564
Activation of the AP-1 family of transcription factors	R-HSA-450341	4.278562e-01	0.369
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.278562e-01	0.369
Interleukin-1 processing	R-HSA-448706	4.278562e-01	0.369
Basigin interactions	R-HSA-210991	3.408068e-01	0.467
Amino acid transport across the plasma membrane	R-HSA-352230	3.788759e-01	0.422
MyD88 cascade initiated on plasma membrane	R-HSA-975871	3.963479e-01	0.402
Adherens junctions interactions	R-HSA-418990	4.291627e-01	0.367
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	3.963479e-01	0.402
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	3.963479e-01	0.402
Protein ubiquitination	R-HSA-8852135	1.930333e-01	0.714
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.246214e-01	0.904
FLT3 Signaling	R-HSA-9607240	3.861142e-01	0.413
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.652537e-01	0.782
Neurodegenerative Diseases	R-HSA-8863678	1.652537e-01	0.782
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	2.899175e-01	0.538
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.998501e-01	0.699
Adrenoceptors	R-HSA-390696	4.005955e-01	0.397
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	4.005955e-01	0.397
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.686680e-01	0.773
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.899175e-01	0.538
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	4.278562e-01	0.369
Cellular response to mitochondrial stress	R-HSA-9840373	4.278562e-01	0.369
Sphingolipid de novo biosynthesis	R-HSA-1660661	3.892864e-01	0.410
Apoptosis	R-HSA-109581	1.394420e-01	0.856
Influenza Infection	R-HSA-168255	2.166597e-01	0.664
Death Receptor Signaling	R-HSA-73887	2.827375e-01	0.549
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.327043e-01	0.877
ROBO receptors bind AKAP5	R-HSA-9010642	4.005955e-01	0.397
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	3.239435e-01	0.490
tRNA processing in the nucleus	R-HSA-6784531	4.100277e-01	0.387
Inositol phosphate metabolism	R-HSA-1483249	3.562841e-01	0.448
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.475681e-01	0.459
Estrogen-dependent gene expression	R-HSA-9018519	4.187213e-01	0.378
Syndecan interactions	R-HSA-3000170	3.905031e-01	0.408
Nectin/Necl trans heterodimerization	R-HSA-420597	2.779510e-01	0.556
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.278562e-01	0.369
Mismatch Repair	R-HSA-5358508	2.899175e-01	0.538
Interleukin-7 signaling	R-HSA-1266695	1.765854e-01	0.753
Programmed Cell Death	R-HSA-5357801	3.567541e-01	0.448
GP1b-IX-V activation signalling	R-HSA-430116	4.278562e-01	0.369
Signaling by TGF-beta Receptor Complex	R-HSA-170834	3.881605e-01	0.411
PTEN Regulation	R-HSA-6807070	4.395625e-01	0.357
Signaling by Leptin	R-HSA-2586552	4.538787e-01	0.343
Unfolded Protein Response (UPR)	R-HSA-381119	4.395625e-01	0.357
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.005955e-01	0.397
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	2.987538e-01	0.525
Semaphorin interactions	R-HSA-373755	4.203455e-01	0.376
SLC-mediated transport of inorganic anions	R-HSA-9958790	3.485371e-01	0.458
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.215515e-01	0.655
NPAS4 regulates expression of target genes	R-HSA-9768919	2.981473e-01	0.526
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.730727e-01	0.564
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	1.712640e-01	0.766
Sema4D in semaphorin signaling	R-HSA-400685	4.226913e-01	0.374
IRE1alpha activates chaperones	R-HSA-381070	3.310165e-01	0.480
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.538787e-01	0.343
XBP1(S) activates chaperone genes	R-HSA-381038	4.526435e-01	0.344
DNA Damage Reversal	R-HSA-73942	2.215515e-01	0.655
MHC class II antigen presentation	R-HSA-2132295	4.535254e-01	0.343
Processive synthesis on the C-strand of the telomere	R-HSA-174414	4.539786e-01	0.343
Signaling by FGFR3 in disease	R-HSA-5655332	4.539786e-01	0.343
Signaling by NTRK2 (TRKB)	R-HSA-9006115	4.539786e-01	0.343
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	4.594060e-01	0.338
Condensation of Prophase Chromosomes	R-HSA-2299718	4.594060e-01	0.338
Diseases of DNA repair	R-HSA-9675135	4.594060e-01	0.338
Host Interactions of HIV factors	R-HSA-162909	4.609365e-01	0.336
G-protein mediated events	R-HSA-112040	4.611259e-01	0.336
SLC-mediated transport of amino acids	R-HSA-9958863	4.611259e-01	0.336
Chaperonin-mediated protein folding	R-HSA-390466	4.615539e-01	0.336
Negative regulation of FGFR3 signaling	R-HSA-5654732	4.692541e-01	0.329
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.704216e-01	0.328
Peptide chain elongation	R-HSA-156902	4.704216e-01	0.328
Recycling pathway of L1	R-HSA-437239	4.712737e-01	0.327
Clathrin-mediated endocytosis	R-HSA-8856828	4.740512e-01	0.324
G1/S Transition	R-HSA-69206	4.756900e-01	0.323
Gene Silencing by RNA	R-HSA-211000	4.774190e-01	0.321
Synthesis of PI	R-HSA-1483226	4.787191e-01	0.320
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.787191e-01	0.320
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	4.787191e-01	0.320
PECAM1 interactions	R-HSA-210990	4.787191e-01	0.320
Transport of RCbl within the body	R-HSA-9758890	4.787191e-01	0.320
CD163 mediating an anti-inflammatory response	R-HSA-9662834	4.787191e-01	0.320
Co-stimulation by CD28	R-HSA-389356	4.830219e-01	0.316
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.830219e-01	0.316
G2/M Transition	R-HSA-69275	4.831877e-01	0.316
Late endosomal microautophagy	R-HSA-9615710	4.842710e-01	0.315
Negative regulation of FGFR4 signaling	R-HSA-5654733	4.842710e-01	0.315
Termination of translesion DNA synthesis	R-HSA-5656169	4.842710e-01	0.315
Regulation of gene expression in beta cells	R-HSA-210745	4.842710e-01	0.315
Downstream signaling of activated FGFR3	R-HSA-5654708	4.842710e-01	0.315
Signaling by Erythropoietin	R-HSA-9006335	4.842710e-01	0.315
DARPP-32 events	R-HSA-180024	4.842710e-01	0.315
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.842710e-01	0.315
SARS-CoV-2-host interactions	R-HSA-9705683	4.848488e-01	0.314
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	4.853778e-01	0.314
Base Excision Repair	R-HSA-73884	4.880142e-01	0.312
Interleukin-17 signaling	R-HSA-448424	4.910455e-01	0.309
MyD88 dependent cascade initiated on endosome	R-HSA-975155	4.932983e-01	0.307
DNA Damage Bypass	R-HSA-73893	4.946442e-01	0.306
Gap junction trafficking and regulation	R-HSA-157858	4.946442e-01	0.306
Mitotic G2-G2/M phases	R-HSA-453274	4.953047e-01	0.305
Transcriptional Regulation by TP53	R-HSA-3700989	4.955572e-01	0.305
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	4.967324e-01	0.304
Downstream signaling of activated FGFR4	R-HSA-5654716	4.990214e-01	0.302
Downregulation of ERBB2 signaling	R-HSA-8863795	4.990214e-01	0.302
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	5.008664e-01	0.300
DS-GAG biosynthesis	R-HSA-2022923	5.024311e-01	0.299
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.024311e-01	0.299
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	5.024311e-01	0.299
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	5.024311e-01	0.299
PI3K events in ERBB4 signaling	R-HSA-1250342	5.024311e-01	0.299
Proton-coupled monocarboxylate transport	R-HSA-433692	5.024311e-01	0.299
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	5.024311e-01	0.299
Sensing of DNA Double Strand Breaks	R-HSA-5693548	5.024311e-01	0.299
ERKs are inactivated	R-HSA-202670	5.024311e-01	0.299
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.024311e-01	0.299
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.024311e-01	0.299
Uptake of dietary cobalamins into enterocytes	R-HSA-9758881	5.024311e-01	0.299
PI3K Cascade	R-HSA-109704	5.061347e-01	0.296
Signaling by NTRKs	R-HSA-166520	5.080274e-01	0.294
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	5.106039e-01	0.292
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	5.134983e-01	0.289
Cargo concentration in the ER	R-HSA-5694530	5.134983e-01	0.289
Molecules associated with elastic fibres	R-HSA-2129379	5.134983e-01	0.289
Trafficking of AMPA receptors	R-HSA-399719	5.134983e-01	0.289
Protein folding	R-HSA-391251	5.139965e-01	0.289
Activation of NF-kappaB in B cells	R-HSA-1169091	5.174881e-01	0.286
Switching of origins to a post-replicative state	R-HSA-69052	5.202543e-01	0.284
Potential therapeutics for SARS	R-HSA-9679191	5.214258e-01	0.283
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.245480e-01	0.280
Scavenging by Class F Receptors	R-HSA-3000484	5.250659e-01	0.280
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.250659e-01	0.280
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.250659e-01	0.280
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	5.250659e-01	0.280
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	5.250659e-01	0.280
Role of second messengers in netrin-1 signaling	R-HSA-418890	5.250659e-01	0.280
p75NTR recruits signalling complexes	R-HSA-209543	5.250659e-01	0.280
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.250659e-01	0.280
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	5.250659e-01	0.280
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.250659e-01	0.280
Adipogenesis	R-HSA-9843745	5.263791e-01	0.279
Diseases of mitotic cell cycle	R-HSA-9675126	5.276961e-01	0.278
RNA Polymerase I Promoter Escape	R-HSA-73772	5.286994e-01	0.277
Orc1 removal from chromatin	R-HSA-68949	5.286994e-01	0.277
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.286994e-01	0.277
Transcriptional Regulation by NPAS4	R-HSA-9634815	5.286994e-01	0.277
Signaling by ERBB4	R-HSA-1236394	5.298138e-01	0.276
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	5.310111e-01	0.275
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	5.346952e-01	0.272
Regulation of CDH1 Expression and Function	R-HSA-9764265	5.358983e-01	0.271
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	5.358983e-01	0.271
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	5.394180e-01	0.268
DNA Replication	R-HSA-69306	5.412779e-01	0.267
Negative regulation of FGFR1 signaling	R-HSA-5654726	5.416104e-01	0.266
FGFR1 mutant receptor activation	R-HSA-1839124	5.416104e-01	0.266
G-protein beta:gamma signalling	R-HSA-397795	5.416104e-01	0.266
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.416104e-01	0.266
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	5.416104e-01	0.266
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.416104e-01	0.266
HCMV Early Events	R-HSA-9609690	5.429510e-01	0.265
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	5.429510e-01	0.265
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	5.466722e-01	0.262
Platelet Adhesion to exposed collagen	R-HSA-75892	5.466722e-01	0.262
Maturation of nucleoprotein	R-HSA-9683610	5.466722e-01	0.262
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	5.466722e-01	0.262
Interleukin-6 signaling	R-HSA-1059683	5.466722e-01	0.262
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.466722e-01	0.262
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.474669e-01	0.262
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	5.506780e-01	0.259
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.552374e-01	0.256
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	5.552374e-01	0.256
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	5.560181e-01	0.255
COPI-mediated anterograde transport	R-HSA-6807878	5.560181e-01	0.255
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	5.614376e-01	0.251
L1CAM interactions	R-HSA-373760	5.624682e-01	0.250
Transcriptional regulation by RUNX3	R-HSA-8878159	5.642066e-01	0.249
Integrin cell surface interactions	R-HSA-216083	5.670774e-01	0.246
Removal of the Flap Intermediate	R-HSA-69166	5.672969e-01	0.246
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	5.672969e-01	0.246
cGMP effects	R-HSA-418457	5.672969e-01	0.246
Regulation of KIT signaling	R-HSA-1433559	5.672969e-01	0.246
Signal regulatory protein family interactions	R-HSA-391160	5.672969e-01	0.246
Zinc transporters	R-HSA-435354	5.672969e-01	0.246
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.672969e-01	0.246
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.685746e-01	0.245
Dual Incision in GG-NER	R-HSA-5696400	5.685746e-01	0.245
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	5.685746e-01	0.245
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	5.685746e-01	0.245
Gap junction assembly	R-HSA-190861	5.685746e-01	0.245
NOD1/2 Signaling Pathway	R-HSA-168638	5.685746e-01	0.245
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.685746e-01	0.245
NRAGE signals death through JNK	R-HSA-193648	5.720395e-01	0.243
Downstream signaling of activated FGFR2	R-HSA-5654696	5.816201e-01	0.235
Downstream signaling of activated FGFR1	R-HSA-5654687	5.816201e-01	0.235
PERK regulates gene expression	R-HSA-381042	5.816201e-01	0.235
Signalling to ERKs	R-HSA-187687	5.816201e-01	0.235
IRS-mediated signalling	R-HSA-112399	5.824809e-01	0.235
Signaling by ROBO receptors	R-HSA-376176	5.832350e-01	0.234
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	5.850847e-01	0.233
PKR-mediated signaling	R-HSA-9833482	5.850847e-01	0.233
Signaling by TGFB family members	R-HSA-9006936	5.862588e-01	0.232
G beta:gamma signalling through BTK	R-HSA-8964315	5.869845e-01	0.231
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	5.869845e-01	0.231
DCC mediated attractive signaling	R-HSA-418885	5.869845e-01	0.231
Translesion synthesis by REV1	R-HSA-110312	5.869845e-01	0.231
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	5.869845e-01	0.231
p38MAPK events	R-HSA-171007	5.869845e-01	0.231
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.869845e-01	0.231
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.869845e-01	0.231
IRF3-mediated induction of type I IFN	R-HSA-3270619	5.869845e-01	0.231
Activation of BAD and translocation to mitochondria	R-HSA-111447	5.869845e-01	0.231
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	5.869845e-01	0.231
Protein methylation	R-HSA-8876725	5.869845e-01	0.231
Cell-extracellular matrix interactions	R-HSA-446353	5.869845e-01	0.231
ABC-family proteins mediated transport	R-HSA-382556	5.883009e-01	0.230
Glycolysis	R-HSA-70171	5.883009e-01	0.230
SARS-CoV Infections	R-HSA-9679506	5.891081e-01	0.230
Cellular responses to stimuli	R-HSA-8953897	5.891875e-01	0.230
Lysosome Vesicle Biogenesis	R-HSA-432720	5.943728e-01	0.226
HSF1 activation	R-HSA-3371511	5.943728e-01	0.226
GPVI-mediated activation cascade	R-HSA-114604	5.943728e-01	0.226
RET signaling	R-HSA-8853659	5.943728e-01	0.226
FGFR2 mutant receptor activation	R-HSA-1839126	5.943728e-01	0.226
Selenocysteine synthesis	R-HSA-2408557	5.961689e-01	0.225
TCF dependent signaling in response to WNT	R-HSA-201681	5.963228e-01	0.225
Cell-Cell communication	R-HSA-1500931	5.988074e-01	0.223
Peroxisomal protein import	R-HSA-9033241	6.028722e-01	0.220
Regulation of beta-cell development	R-HSA-186712	6.028722e-01	0.220
Oxidative Stress Induced Senescence	R-HSA-2559580	6.039522e-01	0.219
Interferon Signaling	R-HSA-913531	6.054397e-01	0.218
Translesion synthesis by POLI	R-HSA-5656121	6.057774e-01	0.218
Phosphorylation of the APC/C	R-HSA-176412	6.057774e-01	0.218
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	6.057774e-01	0.218
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.057774e-01	0.218
Killing mechanisms	R-HSA-9664420	6.057774e-01	0.218
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.057774e-01	0.218
Prolonged ERK activation events	R-HSA-169893	6.057774e-01	0.218
Negative regulation of FLT3	R-HSA-9706369	6.057774e-01	0.218
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	6.057774e-01	0.218
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	6.057774e-01	0.218
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	6.057774e-01	0.218
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	6.068324e-01	0.217
Cell-cell junction organization	R-HSA-421270	6.070465e-01	0.217
Viral mRNA Translation	R-HSA-192823	6.116494e-01	0.213
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	6.148790e-01	0.211
Signal Transduction	R-HSA-162582	6.181738e-01	0.209
Elastic fibre formation	R-HSA-1566948	6.189992e-01	0.208
Opioid Signalling	R-HSA-111885	6.192591e-01	0.208
Generic Transcription Pathway	R-HSA-212436	6.229139e-01	0.206
Translesion synthesis by POLK	R-HSA-5655862	6.237163e-01	0.205
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	6.237163e-01	0.205
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	6.237163e-01	0.205
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	6.237163e-01	0.205
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	6.237163e-01	0.205
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	6.237163e-01	0.205
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.237163e-01	0.205
Synthesis of PG	R-HSA-1483148	6.237163e-01	0.205
Activation of HOX genes during differentiation	R-HSA-5619507	6.267798e-01	0.203
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	6.267798e-01	0.203
Oncogenic MAPK signaling	R-HSA-6802957	6.281368e-01	0.202
MAPK6/MAPK4 signaling	R-HSA-5687128	6.281368e-01	0.202
SLC transporter disorders	R-HSA-5619102	6.290325e-01	0.201
Cell junction organization	R-HSA-446728	6.294640e-01	0.201
Stabilization of p53	R-HSA-69541	6.308739e-01	0.200
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	6.322022e-01	0.199
NCAM signaling for neurite out-growth	R-HSA-375165	6.322022e-01	0.199
Cilium Assembly	R-HSA-5617833	6.362699e-01	0.196
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	6.378519e-01	0.195
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	6.408400e-01	0.193
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	6.408400e-01	0.193
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	6.408400e-01	0.193
PI3K events in ERBB2 signaling	R-HSA-1963642	6.408400e-01	0.193
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	6.408400e-01	0.193
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.408400e-01	0.193
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	6.408400e-01	0.193
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.408400e-01	0.193
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	6.416383e-01	0.193
Loss of Nlp from mitotic centrosomes	R-HSA-380259	6.416383e-01	0.193
G1/S DNA Damage Checkpoints	R-HSA-69615	6.416383e-01	0.193
Signaling by PTK6	R-HSA-8848021	6.416383e-01	0.193
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	6.416383e-01	0.193
Toll-like Receptor Cascades	R-HSA-168898	6.417984e-01	0.193
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.424580e-01	0.192
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.424580e-01	0.192
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.424580e-01	0.192
ER to Golgi Anterograde Transport	R-HSA-199977	6.464369e-01	0.189
Platelet degranulation	R-HSA-114608	6.470243e-01	0.189
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	6.487970e-01	0.188
Insulin receptor signalling cascade	R-HSA-74751	6.509028e-01	0.186
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.509028e-01	0.186
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	6.537533e-01	0.185
Transcriptional Regulation by VENTX	R-HSA-8853884	6.537533e-01	0.185
Cellular responses to stress	R-HSA-2262752	6.563339e-01	0.183
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	6.571854e-01	0.182
PKA activation	R-HSA-163615	6.571854e-01	0.182
Synaptic adhesion-like molecules	R-HSA-8849932	6.571854e-01	0.182
PKA activation in glucagon signalling	R-HSA-164378	6.571854e-01	0.182
Polo-like kinase mediated events	R-HSA-156711	6.571854e-01	0.182
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	6.571854e-01	0.182
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	6.571854e-01	0.182
Tie2 Signaling	R-HSA-210993	6.571854e-01	0.182
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.571854e-01	0.182
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	6.599951e-01	0.180
DNA Replication Pre-Initiation	R-HSA-69002	6.630112e-01	0.178
Signaling by RAF1 mutants	R-HSA-9656223	6.647620e-01	0.177
Intra-Golgi traffic	R-HSA-6811438	6.647620e-01	0.177
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	6.647620e-01	0.177
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.665448e-01	0.176
AURKA Activation by TPX2	R-HSA-8854518	6.689151e-01	0.175
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	6.689151e-01	0.175
PI-3K cascade:FGFR3	R-HSA-5654710	6.727878e-01	0.172
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.727878e-01	0.172
Pyrimidine biosynthesis	R-HSA-500753	6.727878e-01	0.172
Germ layer formation at gastrulation	R-HSA-9754189	6.727878e-01	0.172
Other interleukin signaling	R-HSA-449836	6.727878e-01	0.172
O2/CO2 exchange in erythrocytes	R-HSA-1480926	6.727878e-01	0.172
Specification of the neural plate border	R-HSA-9834899	6.727878e-01	0.172
Pre-NOTCH Processing in Golgi	R-HSA-1912420	6.727878e-01	0.172
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	6.727878e-01	0.172
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.727878e-01	0.172
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.727878e-01	0.172
Maturation of nucleoprotein	R-HSA-9694631	6.727878e-01	0.172
The NLRP3 inflammasome	R-HSA-844456	6.727878e-01	0.172
STING mediated induction of host immune responses	R-HSA-1834941	6.727878e-01	0.172
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	6.727878e-01	0.172
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	6.754870e-01	0.170
Downstream TCR signaling	R-HSA-202424	6.758805e-01	0.170
TBC/RABGAPs	R-HSA-8854214	6.859312e-01	0.164
Signaling by SCF-KIT	R-HSA-1433557	6.859312e-01	0.164
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	6.859312e-01	0.164
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	6.862381e-01	0.164
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	6.862381e-01	0.164
PI-3K cascade:FGFR4	R-HSA-5654720	6.876811e-01	0.163
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	6.876811e-01	0.163
Common Pathway of Fibrin Clot Formation	R-HSA-140875	6.876811e-01	0.163
Co-inhibition by CTLA4	R-HSA-389513	6.876811e-01	0.163
Creatine metabolism	R-HSA-71288	6.876811e-01	0.163
Nephrin family interactions	R-HSA-373753	6.876811e-01	0.163
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.914896e-01	0.160
Surfactant metabolism	R-HSA-5683826	6.960979e-01	0.157
Gap junction trafficking	R-HSA-190828	6.960979e-01	0.157
Amine ligand-binding receptors	R-HSA-375280	6.960979e-01	0.157
Disorders of transmembrane transporters	R-HSA-5619115	6.970819e-01	0.157
Signaling by Nuclear Receptors	R-HSA-9006931	7.012963e-01	0.154
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	7.018973e-01	0.154
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.018973e-01	0.154
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.018973e-01	0.154
Signalling to RAS	R-HSA-167044	7.018973e-01	0.154
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.018973e-01	0.154
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	7.018973e-01	0.154
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	7.028744e-01	0.153
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.028744e-01	0.153
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	7.052537e-01	0.152
Assembly of the pre-replicative complex	R-HSA-68867	7.052537e-01	0.152
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.059907e-01	0.151
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.059907e-01	0.151
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	7.059907e-01	0.151
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	7.059907e-01	0.151
Fanconi Anemia Pathway	R-HSA-6783310	7.059907e-01	0.151
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	7.102453e-01	0.149
ECM proteoglycans	R-HSA-3000178	7.109366e-01	0.148
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.109366e-01	0.148
Platelet activation, signaling and aggregation	R-HSA-76002	7.138053e-01	0.146
CS-GAG biosynthesis	R-HSA-2022870	7.154673e-01	0.145
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.154673e-01	0.145
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.154673e-01	0.145
Listeria monocytogenes entry into host cells	R-HSA-8876384	7.154673e-01	0.145
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	7.156135e-01	0.145
Signaling downstream of RAS mutants	R-HSA-9649948	7.156135e-01	0.145
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	7.156135e-01	0.145
Signaling by RAS mutants	R-HSA-6802949	7.156135e-01	0.145
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.156135e-01	0.145
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.156135e-01	0.145
Signaling by TGFBR3	R-HSA-9839373	7.156135e-01	0.145
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	7.188295e-01	0.143
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	7.191982e-01	0.143
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	7.249704e-01	0.140
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.249704e-01	0.140
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.249704e-01	0.140
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	7.265539e-01	0.139
Glucose metabolism	R-HSA-70326	7.283351e-01	0.138
PI-3K cascade:FGFR1	R-HSA-5654689	7.284203e-01	0.138
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.284203e-01	0.138
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.284203e-01	0.138
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	7.284203e-01	0.138
Signaling by KIT in disease	R-HSA-9669938	7.284203e-01	0.138
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.284203e-01	0.138
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	7.284203e-01	0.138
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.284203e-01	0.138
CLEC7A (Dectin-1) signaling	R-HSA-5607764	7.326497e-01	0.135
Intraflagellar transport	R-HSA-5620924	7.340656e-01	0.134
Metal ion SLC transporters	R-HSA-425410	7.340656e-01	0.134
SARS-CoV-2 Infection	R-HSA-9694516	7.348869e-01	0.134
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.407844e-01	0.130
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.407844e-01	0.130
ABC transporters in lipid homeostasis	R-HSA-1369062	7.407844e-01	0.130
Interleukin receptor SHC signaling	R-HSA-912526	7.407844e-01	0.130
Growth hormone receptor signaling	R-HSA-982772	7.407844e-01	0.130
Centrosome maturation	R-HSA-380287	7.415030e-01	0.130
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.429036e-01	0.129
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.429036e-01	0.129
Muscle contraction	R-HSA-397014	7.508314e-01	0.124
HATs acetylate histones	R-HSA-3214847	7.519107e-01	0.124
FOXO-mediated transcription	R-HSA-9614085	7.519107e-01	0.124
Complex III assembly	R-HSA-9865881	7.525863e-01	0.123
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.525863e-01	0.123
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	7.525863e-01	0.123
Interleukin-6 family signaling	R-HSA-6783589	7.525863e-01	0.123
HSF1-dependent transactivation	R-HSA-3371571	7.598262e-01	0.119
PCP/CE pathway	R-HSA-4086400	7.626992e-01	0.118
ABC transporter disorders	R-HSA-5619084	7.626992e-01	0.118
G alpha (12/13) signalling events	R-HSA-416482	7.626992e-01	0.118
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	7.628837e-01	0.118
PI-3K cascade:FGFR2	R-HSA-5654695	7.638516e-01	0.117
VEGFR2 mediated cell proliferation	R-HSA-5218921	7.638516e-01	0.117
TGFBR3 expression	R-HSA-9839394	7.638516e-01	0.117
Laminin interactions	R-HSA-3000157	7.638516e-01	0.117
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.638516e-01	0.117
Hyaluronan degradation	R-HSA-2160916	7.638516e-01	0.117
Defects in cobalamin (B12) metabolism	R-HSA-3296469	7.638516e-01	0.117
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.638516e-01	0.117
Signaling by NOTCH	R-HSA-157118	7.678202e-01	0.115
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	7.679202e-01	0.115
Neurexins and neuroligins	R-HSA-6794361	7.679202e-01	0.115
Uptake and actions of bacterial toxins	R-HSA-5339562	7.679202e-01	0.115
Sensory processing of sound	R-HSA-9659379	7.694439e-01	0.114
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	7.746046e-01	0.111
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.746046e-01	0.111
TRP channels	R-HSA-3295583	7.746046e-01	0.111
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.746046e-01	0.111
Sphingolipid catabolism	R-HSA-9845614	7.746046e-01	0.111
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.746046e-01	0.111
Meiotic synapsis	R-HSA-1221632	7.757759e-01	0.110
Regulation of PTEN stability and activity	R-HSA-8948751	7.757759e-01	0.110
Mitochondrial ribosome-associated quality control	R-HSA-9937383	7.759101e-01	0.110
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	7.788681e-01	0.109
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	7.788681e-01	0.109
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	7.788681e-01	0.109
Interaction between L1 and Ankyrins	R-HSA-445095	7.848686e-01	0.105
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	7.848686e-01	0.105
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	7.848686e-01	0.105
ER Quality Control Compartment (ERQC)	R-HSA-901032	7.848686e-01	0.105
Maturation of hRSV A proteins	R-HSA-9828806	7.848686e-01	0.105
Gastrulation	R-HSA-9758941	7.879823e-01	0.103
Telomere Extension By Telomerase	R-HSA-171319	7.946658e-01	0.100
Phase 0 - rapid depolarisation	R-HSA-5576892	7.946658e-01	0.100
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	7.946658e-01	0.100
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	7.946658e-01	0.100
Inflammasomes	R-HSA-622312	7.946658e-01	0.100
Cytoprotection by HMOX1	R-HSA-9707564	7.948706e-01	0.100
Vesicle-mediated transport	R-HSA-5653656	7.965771e-01	0.099
SARS-CoV-1 Infection	R-HSA-9678108	7.970093e-01	0.099
Viral Infection Pathways	R-HSA-9824446	7.971647e-01	0.098
Ion homeostasis	R-HSA-5578775	7.979619e-01	0.098
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.979619e-01	0.098
SARS-CoV-1-host interactions	R-HSA-9692914	7.980407e-01	0.098
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	8.008495e-01	0.096
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	8.040174e-01	0.095
DNA methylation	R-HSA-5334118	8.040174e-01	0.095
Platelet calcium homeostasis	R-HSA-418360	8.040174e-01	0.095
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.040174e-01	0.095
HCMV Infection	R-HSA-9609646	8.052727e-01	0.094
Protein-protein interactions at synapses	R-HSA-6794362	8.066816e-01	0.093
Meiosis	R-HSA-1500620	8.066816e-01	0.093
MAPK family signaling cascades	R-HSA-5683057	8.067529e-01	0.093
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.095905e-01	0.092
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	8.116517e-01	0.091
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.116517e-01	0.091
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.129436e-01	0.090
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	8.129436e-01	0.090
Activation of BH3-only proteins	R-HSA-114452	8.129436e-01	0.090
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.214638e-01	0.085
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	8.214638e-01	0.085
Cellular response to starvation	R-HSA-9711097	8.267316e-01	0.083
Diseases of programmed cell death	R-HSA-9645723	8.285883e-01	0.082
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.365696e-01	0.077
Transcriptional regulation of granulopoiesis	R-HSA-9616222	8.365696e-01	0.077
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.365696e-01	0.077
Nuclear RNA decay	R-HSA-9930044	8.373590e-01	0.077
Hemostasis	R-HSA-109582	8.406704e-01	0.075
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.423152e-01	0.075
CS/DS degradation	R-HSA-2024101	8.447685e-01	0.073
Acyl chain remodelling of PC	R-HSA-1482788	8.447685e-01	0.073
Glucagon signaling in metabolic regulation	R-HSA-163359	8.447685e-01	0.073
Effects of PIP2 hydrolysis	R-HSA-114508	8.447685e-01	0.073
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	8.518408e-01	0.070
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	8.518408e-01	0.070
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	8.518408e-01	0.070
Mitophagy	R-HSA-5205647	8.518408e-01	0.070
RAF activation	R-HSA-5673000	8.518408e-01	0.070
Calnexin/calreticulin cycle	R-HSA-901042	8.518408e-01	0.070
Hyaluronan metabolism	R-HSA-2142845	8.518408e-01	0.070
Signaling by Insulin receptor	R-HSA-74752	8.529494e-01	0.069
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	8.532598e-01	0.069
Rab regulation of trafficking	R-HSA-9007101	8.579959e-01	0.067
Acyl chain remodelling of PE	R-HSA-1482839	8.585913e-01	0.066
Oncogene Induced Senescence	R-HSA-2559585	8.585913e-01	0.066
Defects in vitamin and cofactor metabolism	R-HSA-3296482	8.585913e-01	0.066
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.650347e-01	0.063
PRC2 methylates histones and DNA	R-HSA-212300	8.650347e-01	0.063
Glycosphingolipid transport	R-HSA-9845576	8.650347e-01	0.063
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.650347e-01	0.063
G1/S-Specific Transcription	R-HSA-69205	8.650347e-01	0.063
RUNX2 regulates bone development	R-HSA-8941326	8.650347e-01	0.063
Developmental Biology	R-HSA-1266738	8.694695e-01	0.061
Voltage gated Potassium channels	R-HSA-1296072	8.711848e-01	0.060
SIRT1 negatively regulates rRNA expression	R-HSA-427359	8.711848e-01	0.060
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	8.711848e-01	0.060
Degradation of DVL	R-HSA-4641258	8.711848e-01	0.060
TRAF6 mediated IRF7 activation	R-HSA-933541	8.711848e-01	0.060
Degradation of AXIN	R-HSA-4641257	8.711848e-01	0.060
Ovarian tumor domain proteases	R-HSA-5689896	8.711848e-01	0.060
Metabolism of folate and pterines	R-HSA-196757	8.711848e-01	0.060
Transmission across Chemical Synapses	R-HSA-112315	8.733811e-01	0.059
Signaling by WNT	R-HSA-195721	8.735036e-01	0.059
Mitochondrial translation elongation	R-HSA-5389840	8.742347e-01	0.058
Degradation of beta-catenin by the destruction complex	R-HSA-195253	8.776534e-01	0.057
Cyclin E associated events during G1/S transition	R-HSA-69202	8.776534e-01	0.057
Mitochondrial translation initiation	R-HSA-5368286	8.819553e-01	0.055
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.826581e-01	0.054
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.826581e-01	0.054
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.843735e-01	0.053
Attenuation phase	R-HSA-3371568	8.880061e-01	0.052
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.880061e-01	0.052
Interleukin-2 family signaling	R-HSA-451927	8.880061e-01	0.052
Transport to the Golgi and subsequent modification	R-HSA-948021	8.881721e-01	0.052
Hedgehog 'off' state	R-HSA-5610787	8.892513e-01	0.051
Interleukin-1 signaling	R-HSA-9020702	8.927458e-01	0.049
Parasitic Infection Pathways	R-HSA-9824443	8.928439e-01	0.049
Leishmania infection	R-HSA-9658195	8.928439e-01	0.049
Hh mutants are degraded by ERAD	R-HSA-5362768	8.931107e-01	0.049
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	8.931107e-01	0.049
Maturation of spike protein	R-HSA-9694548	8.931107e-01	0.049
KEAP1-NFE2L2 pathway	R-HSA-9755511	8.933559e-01	0.049
Signaling by NOTCH4	R-HSA-9013694	8.944136e-01	0.048
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.961704e-01	0.048
MAP2K and MAPK activation	R-HSA-5674135	8.979829e-01	0.047
Degradation of CRY and PER proteins	R-HSA-9932298	8.979829e-01	0.047
Translation of Structural Proteins	R-HSA-9683701	8.979829e-01	0.047
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.982568e-01	0.047
Post-translational protein modification	R-HSA-597592	9.002386e-01	0.046
UCH proteinases	R-HSA-5689603	9.019693e-01	0.045
Interleukin-12 signaling	R-HSA-9020591	9.019693e-01	0.045
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.026334e-01	0.044
PPARA activates gene expression	R-HSA-1989781	9.042317e-01	0.044
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.055552e-01	0.043
Translation of Structural Proteins	R-HSA-9694635	9.055552e-01	0.043
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.070721e-01	0.042
Nuclear Receptor transcription pathway	R-HSA-383280	9.090181e-01	0.041
SLC-mediated transport of organic anions	R-HSA-9955298	9.090181e-01	0.041
RAF/MAP kinase cascade	R-HSA-5673001	9.092363e-01	0.041
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.092983e-01	0.041
HCMV Late Events	R-HSA-9610379	9.092983e-01	0.041
Methylation	R-HSA-156581	9.113087e-01	0.040
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.113087e-01	0.040
G1 Phase	R-HSA-69236	9.113087e-01	0.040
Cyclin D associated events in G1	R-HSA-69231	9.113087e-01	0.040
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.123619e-01	0.040
Neuronal System	R-HSA-112316	9.132938e-01	0.039
Somitogenesis	R-HSA-9824272	9.153524e-01	0.038
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.153524e-01	0.038
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.153524e-01	0.038
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.153524e-01	0.038
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.192120e-01	0.037
Regulation of pyruvate metabolism	R-HSA-9861718	9.192120e-01	0.037
Mitochondrial translation termination	R-HSA-5419276	9.200020e-01	0.036
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	9.217147e-01	0.035
MAPK1/MAPK3 signaling	R-HSA-5684996	9.218015e-01	0.035
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.228958e-01	0.035
Beta-catenin independent WNT signaling	R-HSA-3858494	9.250633e-01	0.034
Selenoamino acid metabolism	R-HSA-2408522	9.252284e-01	0.034
NGF-stimulated transcription	R-HSA-9031628	9.264119e-01	0.033
GPER1 signaling	R-HSA-9634597	9.264119e-01	0.033
Gluconeogenesis	R-HSA-70263	9.264119e-01	0.033
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.268623e-01	0.033
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.272918e-01	0.033
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	9.274190e-01	0.033
Mitochondrial translation	R-HSA-5368287	9.294604e-01	0.032
Signaling by Hedgehog	R-HSA-5358351	9.294604e-01	0.032
Degradation of CDH1	R-HSA-9766229	9.297678e-01	0.032
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.297678e-01	0.032
Chemokine receptors bind chemokines	R-HSA-380108	9.297678e-01	0.032
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.327292e-01	0.030
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.327292e-01	0.030
Regulation of RAS by GAPs	R-HSA-5658442	9.329709e-01	0.030
Parasite infection	R-HSA-9664407	9.336234e-01	0.030
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.336234e-01	0.030
Leishmania phagocytosis	R-HSA-9664417	9.336234e-01	0.030
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.356204e-01	0.029
Hedgehog ligand biogenesis	R-HSA-5358346	9.360281e-01	0.029
Meiotic recombination	R-HSA-912446	9.360281e-01	0.029
Interleukin-12 family signaling	R-HSA-447115	9.376704e-01	0.028
tRNA processing	R-HSA-72306	9.386259e-01	0.028
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.387544e-01	0.027
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.389460e-01	0.027
C-type lectin receptors (CLRs)	R-HSA-5621481	9.403531e-01	0.027
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.417310e-01	0.026
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	9.417310e-01	0.026
Nucleotide biosynthesis	R-HSA-8956320	9.417310e-01	0.026
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.420364e-01	0.026
ER-Phagosome pathway	R-HSA-1236974	9.422661e-01	0.026
Sphingolipid metabolism	R-HSA-428157	9.424298e-01	0.026
Regulation of T cell activation by CD28 family	R-HSA-388841	9.427445e-01	0.026
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.443891e-01	0.025
Neurotransmitter release cycle	R-HSA-112310	9.444413e-01	0.025
Transcriptional regulation by RUNX2	R-HSA-8878166	9.465236e-01	0.024
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.469261e-01	0.024
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.469261e-01	0.024
G alpha (z) signalling events	R-HSA-418597	9.469261e-01	0.024
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	9.493476e-01	0.023
Intrinsic Pathway for Apoptosis	R-HSA-109606	9.493476e-01	0.023
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.500552e-01	0.022
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.505087e-01	0.022
Regulation of CDH1 Function	R-HSA-9764561	9.516587e-01	0.022
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	9.516587e-01	0.022
Sialic acid metabolism	R-HSA-4085001	9.559697e-01	0.020
Cellular response to chemical stress	R-HSA-9711123	9.574756e-01	0.019
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.592399e-01	0.018
Potassium Channels	R-HSA-1296071	9.592399e-01	0.018
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.593882e-01	0.018
Formation of paraxial mesoderm	R-HSA-9793380	9.598967e-01	0.018
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.598967e-01	0.018
Aquaporin-mediated transport	R-HSA-445717	9.598967e-01	0.018
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.617271e-01	0.017
Regulation of insulin secretion	R-HSA-422356	9.623017e-01	0.017
Ion transport by P-type ATPases	R-HSA-936837	9.651412e-01	0.015
Reproduction	R-HSA-1474165	9.658892e-01	0.015
PI Metabolism	R-HSA-1483255	9.677761e-01	0.014
Degradation of the extracellular matrix	R-HSA-1474228	9.682042e-01	0.014
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.682512e-01	0.014
Nicotinate metabolism	R-HSA-196807	9.697007e-01	0.013
RSV-host interactions	R-HSA-9833110	9.713713e-01	0.013
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.713713e-01	0.013
Metabolism of proteins	R-HSA-392499	9.728665e-01	0.012
Platelet homeostasis	R-HSA-418346	9.735497e-01	0.012
COPII-mediated vesicle transport	R-HSA-204005	9.736644e-01	0.012
Glycosphingolipid catabolism	R-HSA-9840310	9.736644e-01	0.012
Co-inhibition by PD-1	R-HSA-389948	9.747906e-01	0.011
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	9.748671e-01	0.011
Regulation of mitotic cell cycle	R-HSA-453276	9.748671e-01	0.011
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.755677e-01	0.011
Antigen processing-Cross presentation	R-HSA-1236975	9.755677e-01	0.011
Stimuli-sensing channels	R-HSA-2672351	9.755677e-01	0.011
Developmental Lineages of the Mammary Gland	R-HSA-9924644	9.760148e-01	0.011
Glycerophospholipid biosynthesis	R-HSA-1483206	9.770176e-01	0.010
Ca2+ pathway	R-HSA-4086398	9.771103e-01	0.010
Aspirin ADME	R-HSA-9749641	9.771103e-01	0.010
Developmental Cell Lineages	R-HSA-9734767	9.773489e-01	0.010
Cytokine Signaling in Immune system	R-HSA-1280215	9.781668e-01	0.010
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.782603e-01	0.010
Leishmania parasite growth and survival	R-HSA-9664433	9.782603e-01	0.010
Citric acid cycle (TCA cycle)	R-HSA-71403	9.791535e-01	0.009
FCERI mediated MAPK activation	R-HSA-2871796	9.791667e-01	0.009
Pre-NOTCH Expression and Processing	R-HSA-1912422	9.799828e-01	0.009
FCERI mediated NF-kB activation	R-HSA-2871837	9.807032e-01	0.008
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.807439e-01	0.008
TP53 Regulates Metabolic Genes	R-HSA-5628897	9.822497e-01	0.008
Extracellular matrix organization	R-HSA-1474244	9.825330e-01	0.008
Role of phospholipids in phagocytosis	R-HSA-2029485	9.829484e-01	0.007
Amyloid fiber formation	R-HSA-977225	9.842536e-01	0.007
Adaptive Immune System	R-HSA-1280218	9.845228e-01	0.007
Interleukin-1 family signaling	R-HSA-446652	9.855718e-01	0.006
Protein localization	R-HSA-9609507	9.860904e-01	0.006
SLC-mediated transmembrane transport	R-HSA-425407	9.863809e-01	0.006
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.868081e-01	0.006
Neutrophil degranulation	R-HSA-6798695	9.875476e-01	0.005
Regulation of Complement cascade	R-HSA-977606	9.886166e-01	0.005
Signaling by Interleukins	R-HSA-449147	9.886485e-01	0.005
Pyruvate metabolism	R-HSA-70268	9.886509e-01	0.005
Interferon gamma signaling	R-HSA-877300	9.888454e-01	0.005
G alpha (i) signalling events	R-HSA-418594	9.894287e-01	0.005
Class B/2 (Secretin family receptors)	R-HSA-373080	9.901374e-01	0.004
Pre-NOTCH Transcription and Translation	R-HSA-1912408	9.905884e-01	0.004
Phospholipid metabolism	R-HSA-1483257	9.909921e-01	0.004
Cardiac conduction	R-HSA-5576891	9.917859e-01	0.004
Cell surface interactions at the vascular wall	R-HSA-202733	9.924948e-01	0.003
G alpha (s) signalling events	R-HSA-418555	9.931290e-01	0.003
Integration of energy metabolism	R-HSA-163685	9.935794e-01	0.003
Synthesis of bile acids and bile salts	R-HSA-192105	9.941070e-01	0.003
Complement cascade	R-HSA-166658	9.957534e-01	0.002
Neddylation	R-HSA-8951664	9.959974e-01	0.002
Peptide ligand-binding receptors	R-HSA-375276	9.961095e-01	0.002
Ion channel transport	R-HSA-983712	9.965318e-01	0.002
Bile acid and bile salt metabolism	R-HSA-194068	9.966413e-01	0.001
Infectious disease	R-HSA-5663205	9.968248e-01	0.001
Initial triggering of complement	R-HSA-166663	9.973431e-01	0.001
Glycosphingolipid metabolism	R-HSA-1660662	9.983377e-01	0.001
Formation of the cornified envelope	R-HSA-6809371	9.984139e-01	0.001
Asparagine N-linked glycosylation	R-HSA-446203	9.987282e-01	0.001
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.989603e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.991719e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.993292e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.994628e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.996123e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.997210e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.998516e-01	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.998912e-01	0.000
Disease	R-HSA-1643685	9.998939e-01	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	9.998940e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999009e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999253e-01	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999555e-01	0.000
Signaling by GPCR	R-HSA-372790	9.999658e-01	0.000
Innate Immune System	R-HSA-168249	9.999722e-01	0.000
Keratinization	R-HSA-6805567	9.999747e-01	0.000
Drug ADME	R-HSA-9748784	9.999857e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999857e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999930e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999939e-01	0.000
Transport of small molecules	R-HSA-382551	9.999943e-01	0.000
Phase II - Conjugation of compounds	R-HSA-156580	9.999947e-01	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	9.999974e-01	0.000
Immune System	R-HSA-168256	9.999980e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999992e-01	0.000
GPCR ligand binding	R-HSA-500792	9.999997e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Biological oxidations	R-HSA-211859	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955
Metabolism of RNA	R-HSA-8953854	1.110223e-16	15.955
Cell Cycle, Mitotic	R-HSA-69278	6.994405e-15	14.155
M Phase	R-HSA-68886	2.561062e-12	11.592
G2/M Checkpoints	R-HSA-69481	2.423484e-11	10.616
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.609547e-10	9.793
Cell Cycle Checkpoints	R-HSA-69620	2.916282e-10	9.535
rRNA processing in the nucleus and cytosol	R-HSA-8868773	4.111484e-10	9.386
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	3.983676e-10	9.400
Chromatin organization	R-HSA-4839726	4.848293e-10	9.314
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.064081e-09	8.973
mRNA Splicing - Major Pathway	R-HSA-72163	1.105991e-09	8.956
Cellular responses to stimuli	R-HSA-8953897	1.642386e-09	8.785
Chromatin modifying enzymes	R-HSA-3247509	2.061857e-09	8.686
mRNA Splicing	R-HSA-72172	2.397415e-09	8.620
Cellular responses to stress	R-HSA-2262752	4.432643e-09	8.353
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	8.004291e-09	8.097
Cell-Cell communication	R-HSA-1500931	8.070630e-09	8.093
G2/M DNA damage checkpoint	R-HSA-69473	1.768028e-08	7.753
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	8.096473e-08	7.092
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	8.096473e-08	7.092
Regulation of CDH1 Expression and Function	R-HSA-9764265	8.204766e-08	7.086
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	8.204766e-08	7.086
Cell junction organization	R-HSA-446728	1.089028e-07	6.963
rRNA processing	R-HSA-72312	1.161662e-07	6.935
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.583240e-07	6.800
Cap-dependent Translation Initiation	R-HSA-72737	1.565091e-07	6.805
Eukaryotic Translation Initiation	R-HSA-72613	1.565091e-07	6.805
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.769825e-07	6.752
Translation initiation complex formation	R-HSA-72649	2.250163e-07	6.648
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	2.307801e-07	6.637
Adherens junctions interactions	R-HSA-418990	2.358118e-07	6.627
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.863776e-07	6.543
Processing of DNA double-strand break ends	R-HSA-5693607	3.185884e-07	6.497
Mitotic Prophase	R-HSA-68875	3.168696e-07	6.499
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	3.464670e-07	6.460
Ribosomal scanning and start codon recognition	R-HSA-72702	3.859518e-07	6.413
Oxidative Stress Induced Senescence	R-HSA-2559580	4.655365e-07	6.332
DNA Double Strand Break Response	R-HSA-5693606	4.802309e-07	6.319
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.935707e-07	6.307
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.856598e-07	6.232
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	5.733918e-07	6.242
Aggrephagy	R-HSA-9646399	7.111316e-07	6.148
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	7.111316e-07	6.148
Protein ubiquitination	R-HSA-8852135	8.929294e-07	6.049
Mitotic Anaphase	R-HSA-68882	9.294213e-07	6.032
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.046705e-06	5.980
Cell-cell junction organization	R-HSA-421270	1.079479e-06	5.967
Mitotic Prometaphase	R-HSA-68877	1.248172e-06	5.904
Regulation of endogenous retroelements	R-HSA-9842860	1.330350e-06	5.876
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.369372e-06	5.863
Signaling by ALK in cancer	R-HSA-9700206	1.369372e-06	5.863
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	1.625924e-06	5.789
Separation of Sister Chromatids	R-HSA-2467813	1.705788e-06	5.768
DNA Double-Strand Break Repair	R-HSA-5693532	2.167683e-06	5.664
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	2.343032e-06	5.630
Cellular Senescence	R-HSA-2559583	2.871159e-06	5.542
ISG15 antiviral mechanism	R-HSA-1169408	2.819563e-06	5.550
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.142735e-06	5.503
SARS-CoV-1-host interactions	R-HSA-9692914	3.151301e-06	5.502
HDACs deacetylate histones	R-HSA-3214815	3.816235e-06	5.418
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.063776e-06	5.391
Epigenetic regulation of gene expression	R-HSA-212165	5.155201e-06	5.288
RNA Polymerase I Transcription	R-HSA-73864	5.145772e-06	5.289
rRNA modification in the nucleus and cytosol	R-HSA-6790901	7.042650e-06	5.152
Apoptosis	R-HSA-109581	7.083077e-06	5.150
Meiotic synapsis	R-HSA-1221632	8.126124e-06	5.090
L1CAM interactions	R-HSA-373760	8.065347e-06	5.093
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.790822e-06	5.009
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.038567e-05	4.984
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.073391e-05	4.969
Regulation of TP53 Activity	R-HSA-5633007	1.250121e-05	4.903
DNA Replication Pre-Initiation	R-HSA-69002	1.333211e-05	4.875
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	1.344998e-05	4.871
Assembly of the pre-replicative complex	R-HSA-68867	1.368833e-05	4.864
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	1.396037e-05	4.855
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.670761e-05	4.777
Apoptotic execution phase	R-HSA-75153	1.819591e-05	4.740
HIV Life Cycle	R-HSA-162587	1.941464e-05	4.712
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.874933e-05	4.727
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.545209e-05	4.594
Homology Directed Repair	R-HSA-5693538	2.662618e-05	4.575
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.784241e-05	4.555
Eukaryotic Translation Elongation	R-HSA-156842	3.097654e-05	4.509
Post NMDA receptor activation events	R-HSA-438064	3.106307e-05	4.508
Nervous system development	R-HSA-9675108	3.026904e-05	4.519
Transcriptional Regulation by TP53	R-HSA-3700989	3.112746e-05	4.507
Interleukin-12 signaling	R-HSA-9020591	2.998285e-05	4.523
NoRC negatively regulates rRNA expression	R-HSA-427413	3.455740e-05	4.461
Diseases of programmed cell death	R-HSA-9645723	3.659810e-05	4.437
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	4.145870e-05	4.382
PRC2 methylates histones and DNA	R-HSA-212300	5.334928e-05	4.273
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	5.448715e-05	4.264
Axon guidance	R-HSA-422475	5.714475e-05	4.243
G2/M Transition	R-HSA-69275	5.714595e-05	4.243
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	6.123121e-05	4.213
Activation of ATR in response to replication stress	R-HSA-176187	6.939405e-05	4.159
Mitotic G2-G2/M phases	R-HSA-453274	7.019259e-05	4.154
ESR-mediated signaling	R-HSA-8939211	7.247746e-05	4.140
Estrogen-dependent gene expression	R-HSA-9018519	7.481702e-05	4.126
G1/S Transition	R-HSA-69206	7.676702e-05	4.115
Interleukin-12 family signaling	R-HSA-447115	8.189639e-05	4.087
Cohesin Loading onto Chromatin	R-HSA-2470946	9.259203e-05	4.033
Selective autophagy	R-HSA-9663891	9.552144e-05	4.020
Deubiquitination	R-HSA-5688426	9.836925e-05	4.007
FLT3 signaling by CBL mutants	R-HSA-9706377	9.899502e-05	4.004
HATs acetylate histones	R-HSA-3214847	1.030660e-04	3.987
Programmed Cell Death	R-HSA-5357801	1.030670e-04	3.987
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.135956e-04	3.945
HDMs demethylate histones	R-HSA-3214842	1.124391e-04	3.949
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.138745e-04	3.944
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.161517e-04	3.935
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.244518e-04	3.905
Meiosis	R-HSA-1500620	1.328393e-04	3.877
S Phase	R-HSA-69242	1.529353e-04	3.815
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.584328e-04	3.800
PKR-mediated signaling	R-HSA-9833482	1.584328e-04	3.800
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.604304e-04	3.795
COPI-mediated anterograde transport	R-HSA-6807878	1.645738e-04	3.784
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	1.653331e-04	3.782
Regulation of TP53 Degradation	R-HSA-6804757	1.880805e-04	3.726
Regulation of CDH1 Function	R-HSA-9764561	1.824909e-04	3.739
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	1.851174e-04	3.733
Condensation of Prophase Chromosomes	R-HSA-2299718	1.950369e-04	3.710
Signaling by RAF1 mutants	R-HSA-9656223	2.168390e-04	3.664
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	2.187570e-04	3.660
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	2.234898e-04	3.651
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.277537e-04	3.643
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.366072e-04	3.626
Recycling pathway of L1	R-HSA-437239	2.383592e-04	3.623
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.397433e-04	3.620
Ub-specific processing proteases	R-HSA-5689880	2.583274e-04	3.588
DNA Replication	R-HSA-69306	2.600014e-04	3.585
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.518024e-04	3.599
SARS-CoV-1 Infection	R-HSA-9678108	3.129506e-04	3.505
Defective pyroptosis	R-HSA-9710421	3.283212e-04	3.484
DNA methylation	R-HSA-5334118	3.345990e-04	3.475
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	3.359322e-04	3.474
Late Phase of HIV Life Cycle	R-HSA-162599	3.513344e-04	3.454
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.646120e-04	3.438
Transcriptional Regulation by E2F6	R-HSA-8953750	3.665966e-04	3.436
Regulation of TP53 Expression and Degradation	R-HSA-6806003	3.665966e-04	3.436
HIV Infection	R-HSA-162906	3.786936e-04	3.422
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.162735e-04	3.381
RNA Polymerase II Pre-transcription Events	R-HSA-674695	4.173859e-04	3.379
SARS-CoV-2-host interactions	R-HSA-9705683	4.109165e-04	3.386
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.278090e-04	3.369
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.278090e-04	3.369
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	4.338806e-04	3.363
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.341139e-04	3.362
ATP-dependent chromatin remodelers	R-HSA-9932444	4.400503e-04	3.356
SWI/SNF chromatin remodelers	R-HSA-9932451	4.400503e-04	3.356
Translation	R-HSA-72766	4.541805e-04	3.343
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	4.678577e-04	3.330
DNA Repair	R-HSA-73894	4.835468e-04	3.316
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	4.858821e-04	3.313
Nucleosome assembly	R-HSA-774815	4.858821e-04	3.313
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	5.297761e-04	3.276
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.341950e-04	3.272
Signaling by ROBO receptors	R-HSA-376176	5.494148e-04	3.260
Signaling downstream of RAS mutants	R-HSA-9649948	5.863535e-04	3.232
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.863535e-04	3.232
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.863535e-04	3.232
Signaling by RAS mutants	R-HSA-6802949	5.863535e-04	3.232
Regulation of localization of FOXO transcription factors	R-HSA-9614399	6.886491e-04	3.162
Viral Infection Pathways	R-HSA-9824446	7.114849e-04	3.148
Transport of connexons to the plasma membrane	R-HSA-190872	7.230039e-04	3.141
RNA Polymerase I Promoter Opening	R-HSA-73728	7.302964e-04	3.137
Packaging Of Telomere Ends	R-HSA-171306	7.302964e-04	3.137
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	7.436928e-04	3.129
Formation of a pool of free 40S subunits	R-HSA-72689	7.894491e-04	3.103
Ca-dependent events	R-HSA-111996	8.151868e-04	3.089
Assembly of the ORC complex at the origin of replication	R-HSA-68616	8.513946e-04	3.070
Signaling by VEGF	R-HSA-194138	7.920716e-04	3.101
Transcriptional regulation by small RNAs	R-HSA-5578749	7.812280e-04	3.107
Interferon Signaling	R-HSA-913531	8.029054e-04	3.095
Ribosome-associated quality control	R-HSA-9948299	8.763980e-04	3.057
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	8.856290e-04	3.053
p75NTR signals via NF-kB	R-HSA-193639	8.856290e-04	3.053
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.856290e-04	3.053
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	9.462383e-04	3.024
Cellular response to heat stress	R-HSA-3371556	9.713800e-04	3.013
PLC beta mediated events	R-HSA-112043	9.760782e-04	3.011
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	9.767078e-04	3.010
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.967368e-04	3.001
NF-kB is activated and signals survival	R-HSA-209560	1.023372e-03	2.990
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.023372e-03	2.990
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.058727e-03	2.975
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.058727e-03	2.975
Transcriptional regulation by RUNX1	R-HSA-8878171	1.131316e-03	2.946
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.281739e-03	2.892
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.293565e-03	2.888
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.315032e-03	2.881
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.315032e-03	2.881
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.195687e-03	2.922
Peptide chain elongation	R-HSA-156902	1.335430e-03	2.874
Autophagy	R-HSA-9612973	1.355935e-03	2.868
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.368601e-03	2.864
Downregulation of ERBB2 signaling	R-HSA-8863795	1.450241e-03	2.839
p75NTR recruits signalling complexes	R-HSA-209543	1.474328e-03	2.831
Oncogene Induced Senescence	R-HSA-2559585	1.577390e-03	2.802
Influenza Infection	R-HSA-168255	1.602520e-03	2.795
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.634778e-03	2.787
Orc1 removal from chromatin	R-HSA-68949	1.637652e-03	2.786
Formation of RNA Pol II elongation complex	R-HSA-112382	1.637652e-03	2.786
RNA Polymerase I Promoter Escape	R-HSA-73772	1.637652e-03	2.786
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	1.642491e-03	2.784
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	1.755570e-03	2.756
Eukaryotic Translation Termination	R-HSA-72764	1.747315e-03	2.758
HCMV Early Events	R-HSA-9609690	1.883861e-03	2.725
CaM pathway	R-HSA-111997	1.910601e-03	2.719
Calmodulin induced events	R-HSA-111933	1.910601e-03	2.719
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.910601e-03	2.719
Gene expression (Transcription)	R-HSA-74160	1.804943e-03	2.744
Signaling by Hedgehog	R-HSA-5358351	1.730567e-03	2.762
G1/S-Specific Transcription	R-HSA-69205	1.910601e-03	2.719
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.810465e-03	2.742
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.914005e-03	2.718
Smooth Muscle Contraction	R-HSA-445355	1.914005e-03	2.718
Signaling by EGFR in Cancer	R-HSA-1643713	1.991645e-03	2.701
Regulation of PTEN gene transcription	R-HSA-8943724	2.131128e-03	2.671
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.145662e-03	2.668
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.145662e-03	2.668
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	2.145662e-03	2.668
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.145662e-03	2.668
Switching of origins to a post-replicative state	R-HSA-69052	2.156753e-03	2.666
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.185495e-03	2.660
G0 and Early G1	R-HSA-1538133	2.195021e-03	2.659
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.195021e-03	2.659
Signaling by Hippo	R-HSA-2028269	2.198846e-03	2.658
Macroautophagy	R-HSA-1632852	2.271064e-03	2.644
G-protein mediated events	R-HSA-112040	2.309668e-03	2.636
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.347280e-03	2.629
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	2.433681e-03	2.614
Folding of actin by CCT/TriC	R-HSA-390450	2.433681e-03	2.614
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	2.433681e-03	2.614
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	2.477637e-03	2.606
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	2.669582e-03	2.574
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	2.669582e-03	2.574
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	2.748281e-03	2.561
MITF-M-dependent gene expression	R-HSA-9856651	2.860220e-03	2.544
Chaperone Mediated Autophagy	R-HSA-9613829	2.874857e-03	2.541
Striated Muscle Contraction	R-HSA-390522	3.223644e-03	2.492
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	3.338130e-03	2.476
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	3.329875e-03	2.478
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.014503e-03	2.521
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.054353e-03	2.515
Hedgehog 'off' state	R-HSA-5610787	3.015366e-03	2.521
Golgi-to-ER retrograde transport	R-HSA-8856688	3.403736e-03	2.468
Nuclear Envelope Breakdown	R-HSA-2980766	3.436721e-03	2.464
PTEN Regulation	R-HSA-6807070	3.606720e-03	2.443
Regulation of signaling by CBL	R-HSA-912631	3.702741e-03	2.431
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.702741e-03	2.431
Translesion Synthesis by POLH	R-HSA-110320	3.702741e-03	2.431
DAG and IP3 signaling	R-HSA-1489509	3.777956e-03	2.423
Spry regulation of FGF signaling	R-HSA-1295596	3.788941e-03	2.421
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	3.788941e-03	2.421
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	3.866389e-03	2.413
Chromosome Maintenance	R-HSA-73886	3.907837e-03	2.408
Regulation of PTEN localization	R-HSA-8948747	3.945520e-03	2.404
MITF-M-regulated melanocyte development	R-HSA-9730414	3.977079e-03	2.400
Membrane Trafficking	R-HSA-199991	3.996283e-03	2.398
MAPK6/MAPK4 signaling	R-HSA-5687128	4.068738e-03	2.391
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	4.109643e-03	2.386
Neurodegenerative Diseases	R-HSA-8863678	4.248022e-03	2.372
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	4.248022e-03	2.372
Influenza Viral RNA Transcription and Replication	R-HSA-168273	4.295478e-03	2.367
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	4.549862e-03	2.342
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.703858e-03	2.328
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	4.703858e-03	2.328
Signal transduction by L1	R-HSA-445144	4.703858e-03	2.328
Nephrin family interactions	R-HSA-373753	4.703858e-03	2.328
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	4.849058e-03	2.314
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	5.851954e-03	2.233
Long-term potentiation	R-HSA-9620244	5.224677e-03	2.282
Chaperonin-mediated protein folding	R-HSA-390466	5.631326e-03	2.249
Signaling by ERBB2	R-HSA-1227986	5.137071e-03	2.289
Regulation of NF-kappa B signaling	R-HSA-9758274	4.978391e-03	2.303
Kinesins	R-HSA-983189	5.137071e-03	2.289
RNA Polymerase I Transcription Initiation	R-HSA-73762	6.200569e-03	2.208
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	6.244662e-03	2.204
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	6.425479e-03	2.192
Cleavage of the damaged purine	R-HSA-110331	6.425479e-03	2.192
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	6.564630e-03	2.183
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	6.564630e-03	2.183
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	6.611714e-03	2.180
TCF dependent signaling in response to WNT	R-HSA-201681	6.739860e-03	2.171
Gap junction trafficking and regulation	R-HSA-157858	6.768700e-03	2.169
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.906106e-03	2.161
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	7.181749e-03	2.144
Signaling by EGFR	R-HSA-177929	7.181749e-03	2.144
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.181749e-03	2.144
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	7.315292e-03	2.136
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	7.411011e-03	2.130
ER to Golgi Anterograde Transport	R-HSA-199977	7.426192e-03	2.129
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	7.462162e-03	2.127
Loss of Nlp from mitotic centrosomes	R-HSA-380259	7.462162e-03	2.127
Depurination	R-HSA-73927	7.523704e-03	2.124
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	7.548505e-03	2.122
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	7.631475e-03	2.117
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	7.654291e-03	2.116
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	7.691497e-03	2.114
Interaction between L1 and Ankyrins	R-HSA-445095	7.691497e-03	2.114
Regulation of MECP2 expression and activity	R-HSA-9022692	7.720457e-03	2.112
Signaling by NOTCH	R-HSA-157118	8.089242e-03	2.092
Gap junction trafficking	R-HSA-190828	8.292358e-03	2.081
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	8.301414e-03	2.081
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	8.330596e-03	2.079
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	8.330596e-03	2.079
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	8.330596e-03	2.079
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	8.330596e-03	2.079
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	8.330596e-03	2.079
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	8.330596e-03	2.079
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	8.330596e-03	2.079
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	8.330596e-03	2.079
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	8.330596e-03	2.079
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	8.330596e-03	2.079
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	8.330596e-03	2.079
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	8.682629e-03	2.061
DNA Damage Recognition in GG-NER	R-HSA-5696394	9.101575e-03	2.041
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	8.762797e-03	2.057
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.015408e-02	1.993
Metabolism of non-coding RNA	R-HSA-194441	1.038580e-02	1.984
snRNP Assembly	R-HSA-191859	1.038580e-02	1.984
Protein folding	R-HSA-391251	1.022896e-02	1.990
mTORC1-mediated signalling	R-HSA-166208	8.971693e-03	2.047
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	9.527882e-03	2.021
Meiotic recombination	R-HSA-912446	8.844138e-03	2.053
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	8.971693e-03	2.047
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	9.655297e-03	2.015
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.024047e-02	1.990
HCMV Infection	R-HSA-9609646	9.066930e-03	2.043
Intracellular signaling by second messengers	R-HSA-9006925	1.010391e-02	1.996
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	8.971693e-03	2.047
Transcriptional regulation by RUNX3	R-HSA-8878159	9.113956e-03	2.040
Muscle contraction	R-HSA-397014	1.020313e-02	1.991
Reproduction	R-HSA-1474165	9.874158e-03	2.005
Maturation of protein E	R-HSA-9694493	9.655297e-03	2.015
Maturation of protein E	R-HSA-9683683	9.655297e-03	2.015
AURKA Activation by TPX2	R-HSA-8854518	1.055974e-02	1.976
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.066413e-02	1.972
Calnexin/calreticulin cycle	R-HSA-901042	1.066413e-02	1.972
Cilium Assembly	R-HSA-5617833	1.069803e-02	1.971
SARS-CoV Infections	R-HSA-9679506	1.120600e-02	1.951
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.124989e-02	1.949
NRIF signals cell death from the nucleus	R-HSA-205043	1.124989e-02	1.949
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	1.145085e-02	1.941
Josephin domain DUBs	R-HSA-5689877	1.145085e-02	1.941
Pexophagy	R-HSA-9664873	1.145085e-02	1.941
Amyloid fiber formation	R-HSA-977225	1.166804e-02	1.933
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.170904e-02	1.931
Hh mutants are degraded by ERAD	R-HSA-5362768	1.170904e-02	1.931
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	1.170904e-02	1.931
Signaling by NOTCH4	R-HSA-9013694	1.178036e-02	1.929
Glycolysis	R-HSA-70171	1.194249e-02	1.923
ABC-family proteins mediated transport	R-HSA-382556	1.194249e-02	1.923
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.242227e-02	1.906
Synthesis of DNA	R-HSA-69239	1.257389e-02	1.901
Gene Silencing by RNA	R-HSA-211000	1.257389e-02	1.901
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	1.285653e-02	1.891
Activation of the pre-replicative complex	R-HSA-68962	1.293903e-02	1.888
Activation of BH3-only proteins	R-HSA-114452	1.293903e-02	1.888
Platelet degranulation	R-HSA-114608	1.299870e-02	1.886
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	1.310244e-02	1.883
Transcription of the HIV genome	R-HSA-167172	1.313210e-02	1.882
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.313210e-02	1.882
MAP2K and MAPK activation	R-HSA-5674135	1.343923e-02	1.872
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	1.409548e-02	1.851
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.418808e-02	1.848
Signaling by LTK in cancer	R-HSA-9842640	1.429344e-02	1.845
IRF3-mediated induction of type I IFN	R-HSA-3270619	1.431133e-02	1.844
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.431133e-02	1.844
Translesion synthesis by REV1	R-HSA-110312	1.431133e-02	1.844
Protein methylation	R-HSA-8876725	1.431133e-02	1.844
Cell-extracellular matrix interactions	R-HSA-446353	1.431133e-02	1.844
FLT3 signaling in disease	R-HSA-9682385	1.439017e-02	1.842
Signaling by NOTCH3	R-HSA-9012852	1.446617e-02	1.840
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.461375e-02	1.835
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	1.510268e-02	1.821
EGFR downregulation	R-HSA-182971	1.517196e-02	1.819
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.517196e-02	1.819
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	1.528675e-02	1.816
Cleavage of the damaged pyrimidine	R-HSA-110329	1.535623e-02	1.814
Depyrimidination	R-HSA-73928	1.535623e-02	1.814
Cellular response to starvation	R-HSA-9711097	1.610362e-02	1.793
Cyclin E associated events during G1/S transition	R-HSA-69202	1.616720e-02	1.791
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.658189e-02	1.780
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.658189e-02	1.780
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	1.814398e-02	1.741
Recycling of eIF2:GDP	R-HSA-72731	2.014027e-02	1.696
Condensation of Prometaphase Chromosomes	R-HSA-2514853	1.989738e-02	1.701
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.989738e-02	1.701
Negative regulation of FLT3	R-HSA-9706369	1.790914e-02	1.747
Translesion synthesis by POLI	R-HSA-5656121	1.790914e-02	1.747
Translesion synthesis by POLK	R-HSA-5655862	2.208206e-02	1.656
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.870956e-02	1.728
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.870956e-02	1.728
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.046826e-02	1.689
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	2.256898e-02	1.646
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.256898e-02	1.646
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.169580e-02	1.664
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	2.169580e-02	1.664
Co-inhibition by PD-1	R-HSA-389948	1.947108e-02	1.711
Telomere Maintenance	R-HSA-157579	1.743141e-02	1.759
Oncogenic MAPK signaling	R-HSA-6802957	1.708121e-02	1.767
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.989738e-02	1.701
Regulation of T cell activation by CD28 family	R-HSA-388841	1.928462e-02	1.715
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.971457e-02	1.705
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.208206e-02	1.656
RMTs methylate histone arginines	R-HSA-3214858	1.979654e-02	1.703
Hh mutants abrogate ligand secretion	R-HSA-5387390	1.747154e-02	1.758
Mitotic Spindle Checkpoint	R-HSA-69618	2.226872e-02	1.652
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	2.208206e-02	1.656
Stabilization of p53	R-HSA-69541	2.169194e-02	1.664
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	2.208206e-02	1.656
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	2.238523e-02	1.650
Defective CFTR causes cystic fibrosis	R-HSA-5678895	2.234237e-02	1.651
Hedgehog ligand biogenesis	R-HSA-5358346	2.016676e-02	1.695
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	2.256898e-02	1.646
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.238523e-02	1.650
Signaling by TGFB family members	R-HSA-9006936	1.832166e-02	1.737
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.814295e-02	1.741
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.234237e-02	1.651
Cytokine Signaling in Immune system	R-HSA-1280215	2.225747e-02	1.653
ER Quality Control Compartment (ERQC)	R-HSA-901032	2.168472e-02	1.664
Unfolded Protein Response (UPR)	R-HSA-381119	2.034423e-02	1.692
SARS-CoV-2 Infection	R-HSA-9694516	2.027215e-02	1.693
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.356500e-02	1.628
Selenocysteine synthesis	R-HSA-2408557	2.409061e-02	1.618
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.463697e-02	1.608
Interactions of Rev with host cellular proteins	R-HSA-177243	2.463697e-02	1.608
Negative regulation of NOTCH4 signaling	R-HSA-9604323	2.463697e-02	1.608
Regulation of RUNX3 expression and activity	R-HSA-8941858	2.463697e-02	1.608
Organelle biogenesis and maintenance	R-HSA-1852241	2.492114e-02	1.603
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	2.511991e-02	1.600
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.517591e-02	1.599
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.517591e-02	1.599
HIV elongation arrest and recovery	R-HSA-167287	2.526765e-02	1.597
Pausing and recovery of HIV elongation	R-HSA-167290	2.526765e-02	1.597
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	2.526765e-02	1.597
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	2.533473e-02	1.596
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	2.533473e-02	1.596
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	2.533473e-02	1.596
IRAK1 recruits IKK complex	R-HSA-937039	2.533473e-02	1.596
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	2.533473e-02	1.596
Centrosome maturation	R-HSA-380287	2.610384e-02	1.583
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.686475e-02	1.571
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.686475e-02	1.571
NPAS4 regulates expression of target genes	R-HSA-9768919	2.698187e-02	1.569
Gap junction assembly	R-HSA-190861	2.698187e-02	1.569
Myoclonic epilepsy of Lafora	R-HSA-3785653	2.726935e-02	1.564
Downregulation of ERBB4 signaling	R-HSA-1253288	2.726935e-02	1.564
Modulation by Mtb of host immune system	R-HSA-9637628	2.726935e-02	1.564
FLT3 Signaling	R-HSA-9607240	2.785898e-02	1.555
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	2.785898e-02	1.555
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	2.799650e-02	1.553
Viral mRNA Translation	R-HSA-192823	2.807203e-02	1.552
Clathrin-mediated endocytosis	R-HSA-8856828	2.812031e-02	1.551
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	2.813966e-02	1.551
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.813966e-02	1.551
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.815348e-02	1.550
UCH proteinases	R-HSA-5689603	2.854255e-02	1.545
TCR signaling	R-HSA-202403	2.867576e-02	1.542
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	2.924421e-02	1.534
Host Interactions of HIV factors	R-HSA-162909	2.948144e-02	1.530
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.023925e-02	1.519
Response of endothelial cells to shear stress	R-HSA-9860931	3.023925e-02	1.519
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	3.038061e-02	1.517
Platelet activation, signaling and aggregation	R-HSA-76002	3.050244e-02	1.516
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	3.073363e-02	1.512
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	3.103936e-02	1.508
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.117265e-02	1.506
Intraflagellar transport	R-HSA-5620924	3.141168e-02	1.503
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.164112e-02	1.500
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.164112e-02	1.500
Membrane binding and targetting of GAG proteins	R-HSA-174490	3.164112e-02	1.500
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	3.164112e-02	1.500
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	3.164112e-02	1.500
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.228735e-02	1.491
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	3.431279e-02	1.465
Nucleotide Excision Repair	R-HSA-5696398	3.494541e-02	1.457
Degradation of CDH1	R-HSA-9766229	3.494554e-02	1.457
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	3.494554e-02	1.457
p53-Dependent G1 DNA Damage Response	R-HSA-69563	3.494554e-02	1.457
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	3.494554e-02	1.457
MTOR signalling	R-HSA-165159	3.518130e-02	1.454
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	3.518284e-02	1.454
Amplification of signal from the kinetochores	R-HSA-141424	3.518284e-02	1.454
Cargo trafficking to the periciliary membrane	R-HSA-5620920	3.533228e-02	1.452
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	3.572812e-02	1.447
GP1b-IX-V activation signalling	R-HSA-430116	3.572812e-02	1.447
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	3.572812e-02	1.447
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.572812e-02	1.447
Cellular response to mitochondrial stress	R-HSA-9840373	3.572812e-02	1.447
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	3.575044e-02	1.447
Nectin/Necl trans heterodimerization	R-HSA-420597	3.575044e-02	1.447
NrCAM interactions	R-HSA-447038	3.575044e-02	1.447
Manipulation of host energy metabolism	R-HSA-9636667	3.820131e-02	1.418
2-LTR circle formation	R-HSA-164843	4.553908e-02	1.342
Sema3A PAK dependent Axon repulsion	R-HSA-399954	4.697936e-02	1.328
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	3.837501e-02	1.416
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.604459e-02	1.251
Class I peroxisomal membrane protein import	R-HSA-9603798	5.604459e-02	1.251
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	3.844588e-02	1.415
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	5.504713e-02	1.259
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	5.504713e-02	1.259
Vpr-mediated nuclear import of PICs	R-HSA-180910	3.929549e-02	1.406
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.557561e-02	1.255
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	4.934584e-02	1.307
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	4.934584e-02	1.307
HIV Transcription Elongation	R-HSA-167169	5.495314e-02	1.260
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	5.495314e-02	1.260
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	5.362559e-02	1.271
mRNA 3'-end processing	R-HSA-72187	4.720493e-02	1.326
Dual incision in TC-NER	R-HSA-6782135	4.158224e-02	1.381
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	5.186952e-02	1.285
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	4.932665e-02	1.307
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.440592e-02	1.264
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	4.940709e-02	1.306
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	3.844588e-02	1.415
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	4.553908e-02	1.342
Metalloprotease DUBs	R-HSA-5689901	4.825261e-02	1.316
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	5.298497e-02	1.276
Budding and maturation of HIV virion	R-HSA-162588	3.844588e-02	1.415
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	4.412946e-02	1.355
Regulation of PTEN stability and activity	R-HSA-8948751	5.186952e-02	1.285
Breakdown of the nuclear lamina	R-HSA-352238	3.820131e-02	1.418
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	4.697936e-02	1.328
Negative regulation of MET activity	R-HSA-6807004	4.514767e-02	1.345
MAPK family signaling cascades	R-HSA-5683057	5.157251e-02	1.288
Ovarian tumor domain proteases	R-HSA-5689896	3.929549e-02	1.406
Cellular responses to mechanical stimuli	R-HSA-9855142	3.787878e-02	1.422
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	4.697936e-02	1.328
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	3.884873e-02	1.411
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	5.504713e-02	1.259
Opioid Signalling	R-HSA-111885	5.218646e-02	1.282
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	4.825261e-02	1.316
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	3.884873e-02	1.411
Interactions of Vpr with host cellular proteins	R-HSA-176033	5.495314e-02	1.260
Early Phase of HIV Life Cycle	R-HSA-162594	5.261988e-02	1.279
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	4.697936e-02	1.328
STING mediated induction of host immune responses	R-HSA-1834941	3.837501e-02	1.416
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	4.940709e-02	1.306
Vpu mediated degradation of CD4	R-HSA-180534	5.557561e-02	1.255
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.370041e-02	1.360
Glucose metabolism	R-HSA-70326	5.222491e-02	1.282
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.934584e-02	1.307
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	5.670165e-02	1.246
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	5.670165e-02	1.246
Base-Excision Repair, AP Site Formation	R-HSA-73929	5.683404e-02	1.245
Signaling by WNT	R-HSA-195721	5.770876e-02	1.239
RNA Polymerase II Transcription	R-HSA-73857	5.888446e-02	1.230
tRNA processing in the nucleus	R-HSA-6784531	5.919998e-02	1.228
Post-translational protein phosphorylation	R-HSA-8957275	5.933746e-02	1.227
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.080070e-02	1.216
Listeria monocytogenes entry into host cells	R-HSA-8876384	6.080070e-02	1.216
PKMTs methylate histone lysines	R-HSA-3214841	6.095837e-02	1.215
Neutrophil degranulation	R-HSA-6798695	6.180445e-02	1.209
Signaling by NOTCH2	R-HSA-1980145	6.221346e-02	1.206
Nuclear import of Rev protein	R-HSA-180746	6.221346e-02	1.206
Mitophagy	R-HSA-5205647	6.221346e-02	1.206
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	6.221346e-02	1.206
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	6.221346e-02	1.206
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	6.240850e-02	1.205
Formation of the Early Elongation Complex	R-HSA-113418	6.240850e-02	1.205
Negative regulation of FGFR3 signaling	R-HSA-5654732	6.240850e-02	1.205
p75 NTR receptor-mediated signalling	R-HSA-193704	6.332743e-02	1.198
Diseases of cellular response to stress	R-HSA-9675132	6.358831e-02	1.197
Diseases of Cellular Senescence	R-HSA-9630747	6.358831e-02	1.197
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	6.358831e-02	1.197
Semaphorin interactions	R-HSA-373755	6.427829e-02	1.192
Gluconeogenesis	R-HSA-70263	6.487716e-02	1.188
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	6.566083e-02	1.183
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.566083e-02	1.183
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.578492e-02	1.182
Regulation of mitotic cell cycle	R-HSA-453276	6.578492e-02	1.182
Hedgehog 'on' state	R-HSA-5632684	6.578492e-02	1.182
Nuclear events mediated by NFE2L2	R-HSA-9759194	6.619624e-02	1.179
Signaling by Nuclear Receptors	R-HSA-9006931	6.631036e-02	1.178
XBP1(S) activates chaperone genes	R-HSA-381038	6.732269e-02	1.172
Degradation of GLI1 by the proteasome	R-HSA-5610780	6.736696e-02	1.172
Degradation of GLI2 by the proteasome	R-HSA-5610783	6.736696e-02	1.172
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	6.736696e-02	1.172
Ion homeostasis	R-HSA-5578775	6.768328e-02	1.170
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	6.768328e-02	1.170
Integration of provirus	R-HSA-162592	6.919434e-02	1.160
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	6.932590e-02	1.159
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	6.932590e-02	1.159
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	6.932590e-02	1.159
Regulation of Apoptosis	R-HSA-169911	6.932590e-02	1.159
Notch-HLH transcription pathway	R-HSA-350054	6.969372e-02	1.157
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.969372e-02	1.157
Late endosomal microautophagy	R-HSA-9615710	7.034143e-02	1.153
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	7.034143e-02	1.153
Signaling by CSF3 (G-CSF)	R-HSA-9674555	7.034143e-02	1.153
Negative regulation of FGFR4 signaling	R-HSA-5654733	7.034143e-02	1.153
DNA Damage Bypass	R-HSA-73893	7.103022e-02	1.149
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	7.418275e-02	1.130
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	7.691589e-02	1.114
RNA Polymerase III Transcription	R-HSA-74158	7.691589e-02	1.114
HSF1 activation	R-HSA-3371511	7.691589e-02	1.114
Vif-mediated degradation of APOBEC3G	R-HSA-180585	7.691589e-02	1.114
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	7.884728e-02	1.103
Signaling by ERBB2 in Cancer	R-HSA-1227990	7.884728e-02	1.103
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.884728e-02	1.103
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.929719e-02	1.101
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	7.929719e-02	1.101
Signaling by FGFR4	R-HSA-5654743	8.140794e-02	1.089
Response of Mtb to phagocytosis	R-HSA-9637690	8.140794e-02	1.089
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	8.297725e-02	1.081
Disorders of Nervous System Development	R-HSA-9697154	8.297725e-02	1.081
Pervasive developmental disorders	R-HSA-9005895	8.297725e-02	1.081
Scavenging by Class F Receptors	R-HSA-3000484	8.297725e-02	1.081
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	8.297725e-02	1.081
VLDLR internalisation and degradation	R-HSA-8866427	8.297725e-02	1.081
Uptake and function of diphtheria toxin	R-HSA-5336415	8.378426e-02	1.077
HSF1-dependent transactivation	R-HSA-3371571	8.440615e-02	1.074
Activation of NF-kappaB in B cells	R-HSA-1169091	8.440615e-02	1.074
Degradation of DVL	R-HSA-4641258	8.498413e-02	1.071
Degradation of AXIN	R-HSA-4641257	8.498413e-02	1.071
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.498413e-02	1.071
HDR through Homologous Recombination (HRR)	R-HSA-5685942	8.739941e-02	1.058
Base Excision Repair	R-HSA-73884	8.751175e-02	1.058
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	8.792404e-02	1.056
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	8.792404e-02	1.056
Trafficking of AMPA receptors	R-HSA-399719	8.792404e-02	1.056
Evasion by RSV of host interferon responses	R-HSA-9833109	8.792404e-02	1.056
Ephrin signaling	R-HSA-3928664	8.881662e-02	1.052
GAB1 signalosome	R-HSA-180292	8.881662e-02	1.052
PKA activation	R-HSA-163615	8.881662e-02	1.052
Apoptotic factor-mediated response	R-HSA-111471	8.881662e-02	1.052
Regulation of TP53 Activity through Methylation	R-HSA-6804760	8.881662e-02	1.052
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.904309e-02	1.050
G1 Phase	R-HSA-69236	8.904309e-02	1.050
Cyclin D associated events in G1	R-HSA-69231	8.904309e-02	1.050
TRAF6 mediated NF-kB activation	R-HSA-933542	8.960417e-02	1.048
Deadenylation of mRNA	R-HSA-429947	8.960417e-02	1.048
Activation of HOX genes during differentiation	R-HSA-5619507	9.109894e-02	1.040
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	9.109894e-02	1.040
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.163146e-02	1.038
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	9.308518e-02	1.031
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	9.315455e-02	1.031
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	9.315455e-02	1.031
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	9.315455e-02	1.031
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	9.315455e-02	1.031
Signaling by NOTCH1 in Cancer	R-HSA-2644603	9.315455e-02	1.031
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	9.389133e-02	1.027
Drug resistance of FLT3 mutants	R-HSA-9702506	9.688885e-02	1.014
FLT3 mutants bind TKIs	R-HSA-9702509	9.688885e-02	1.014
tandutinib-resistant FLT3 mutants	R-HSA-9702636	9.688885e-02	1.014
linifanib-resistant FLT3 mutants	R-HSA-9702998	9.688885e-02	1.014
midostaurin-resistant FLT3 mutants	R-HSA-9702600	9.688885e-02	1.014
sunitinib-resistant FLT3 mutants	R-HSA-9702632	9.688885e-02	1.014
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	R-HSA-9646304	9.688885e-02	1.014
sorafenib-resistant FLT3 mutants	R-HSA-9702624	9.688885e-02	1.014
Evasion of Oncogene Induced Senescence Due to p14ARF Defects	R-HSA-9646303	9.688885e-02	1.014
KW2449-resistant FLT3 mutants	R-HSA-9702569	9.688885e-02	1.014
quizartinib-resistant FLT3 mutants	R-HSA-9702620	9.688885e-02	1.014
gilteritinib-resistant FLT3 mutants	R-HSA-9702590	9.688885e-02	1.014
lestaurtinib-resistant FLT3 mutants	R-HSA-9702596	9.688885e-02	1.014
tamatinib-resistant FLT3 mutants	R-HSA-9703009	9.688885e-02	1.014
crenolanib-resistant FLT3 mutants	R-HSA-9702581	9.688885e-02	1.014
semaxanib-resistant FLT3 mutants	R-HSA-9702577	9.688885e-02	1.014
pexidartinib-resistant FLT3 mutants	R-HSA-9702605	9.688885e-02	1.014
ponatinib-resistant FLT3 mutants	R-HSA-9702614	9.688885e-02	1.014
Asymmetric localization of PCP proteins	R-HSA-4608870	9.708712e-02	1.013
Signaling by FGFR3	R-HSA-5654741	9.708712e-02	1.013
IRE1alpha activates chaperones	R-HSA-381070	9.890958e-02	1.005
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.843954e-01	0.734
Diseases of Telomere Maintenance	R-HSA-9673013	1.843954e-01	0.734
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.843954e-01	0.734
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9632697	1.843954e-01	0.734
UNC93B1 deficiency - HSE	R-HSA-5602415	1.843954e-01	0.734
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.843954e-01	0.734
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.843954e-01	0.734
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.843954e-01	0.734
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.843954e-01	0.734
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.843954e-01	0.734
Hereditary fructose intolerance	R-HSA-5657560	1.843954e-01	0.734
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9630791	1.843954e-01	0.734
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	1.843954e-01	0.734
FLT3 signaling through SRC family kinases	R-HSA-9706374	1.256582e-01	0.901
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.256582e-01	0.901
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	1.256582e-01	0.901
Signaling by MAP2K mutants	R-HSA-9652169	1.256582e-01	0.901
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.604352e-01	0.795
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.604352e-01	0.795
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	1.037815e-01	0.984
Type I hemidesmosome assembly	R-HSA-446107	1.037815e-01	0.984
Formation of annular gap junctions	R-HSA-196025	1.037815e-01	0.984
Gap junction degradation	R-HSA-190873	1.254478e-01	0.902
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.254478e-01	0.902
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	1.966839e-01	0.706
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.966839e-01	0.706
Negative feedback regulation of MAPK pathway	R-HSA-5674499	1.966839e-01	0.706
Noncanonical activation of NOTCH3	R-HSA-9017802	1.966839e-01	0.706
IkBA variant leads to EDA-ID	R-HSA-5603029	1.966839e-01	0.706
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	1.966839e-01	0.706
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.485690e-01	0.828
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	1.485690e-01	0.828
PECAM1 interactions	R-HSA-210990	1.729278e-01	0.762
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.729278e-01	0.762
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	1.314459e-01	0.881
Phosphorylation of the APC/C	R-HSA-176412	1.497117e-01	0.825
Activation of RAC1	R-HSA-428540	1.983094e-01	0.703
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	1.295208e-01	0.888
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.688804e-01	0.772
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	1.122763e-01	0.950
IPs transport between nucleus and cytosol	R-HSA-1855170	1.077661e-01	0.968
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.511182e-01	0.821
Termination of translesion DNA synthesis	R-HSA-5656169	1.511182e-01	0.821
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.511182e-01	0.821
Dual Incision in GG-NER	R-HSA-5696400	1.297884e-01	0.887
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	1.120313e-01	0.951
mRNA Splicing - Minor Pathway	R-HSA-72165	1.055373e-01	0.977
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	1.143893e-01	0.942
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	1.323664e-01	0.878
HIV Transcription Initiation	R-HSA-167161	1.323664e-01	0.878
RNA Polymerase II Transcription Initiation	R-HSA-75953	1.323664e-01	0.878
RNA Polymerase II Transcription Termination	R-HSA-73856	1.003166e-01	0.999
RNA Polymerase II Promoter Escape	R-HSA-73776	1.544452e-01	0.811
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	1.781499e-01	0.749
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.781499e-01	0.749
EPHB-mediated forward signaling	R-HSA-3928662	1.661027e-01	0.780
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	1.697165e-01	0.770
EPH-Ephrin signaling	R-HSA-2682334	1.652886e-01	0.782
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	1.120313e-01	0.951
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	1.120313e-01	0.951
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	1.219746e-01	0.914
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.914601e-01	0.718
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.120313e-01	0.951
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.914601e-01	0.718
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.914601e-01	0.718
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	1.910763e-01	0.719
DNA strand elongation	R-HSA-69190	1.950637e-01	0.710
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.151250e-01	0.939
PKA-mediated phosphorylation of CREB	R-HSA-111931	1.295208e-01	0.888
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.314459e-01	0.881
Disorders of Developmental Biology	R-HSA-9675151	1.688804e-01	0.772
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.604352e-01	0.795
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	1.254478e-01	0.902
Regulation of CDH11 function	R-HSA-9762292	1.485690e-01	0.828
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.141775e-01	0.942
Diseases of mitotic cell cycle	R-HSA-9675126	1.950637e-01	0.710
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.256582e-01	0.901
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	1.536755e-01	0.813
Prolonged ERK activation events	R-HSA-169893	1.497117e-01	0.825
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.332738e-01	0.875
Pyrophosphate hydrolysis	R-HSA-71737	1.604352e-01	0.795
IKK complex recruitment mediated by RIP1	R-HSA-937041	1.015439e-01	0.993
Activation of SMO	R-HSA-5635838	1.497117e-01	0.825
Degradation of CRY and PER proteins	R-HSA-9932298	1.323664e-01	0.878
Fanconi Anemia Pathway	R-HSA-6783310	1.781499e-01	0.749
MAPK1/MAPK3 signaling	R-HSA-5684996	1.718385e-01	0.765
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	1.015439e-01	0.993
ER-Phagosome pathway	R-HSA-1236974	1.339093e-01	0.873
Neurexins and neuroligins	R-HSA-6794361	1.644189e-01	0.784
RAF/MAP kinase cascade	R-HSA-5673001	1.819826e-01	0.740
Signaling by NOTCH1	R-HSA-1980143	1.559591e-01	0.807
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.877668e-01	0.726
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.254478e-01	0.902
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.077320e-01	0.968
MyD88-independent TLR4 cascade	R-HSA-166166	1.877668e-01	0.726
DARPP-32 events	R-HSA-180024	1.511182e-01	0.821
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.492710e-01	0.826
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.212956e-01	0.916
ROBO receptors bind AKAP5	R-HSA-9010642	1.037815e-01	0.984
Regulation of TNFR1 signaling	R-HSA-5357905	1.055373e-01	0.977
Vesicle-mediated transport	R-HSA-5653656	1.106003e-01	0.956
Transcriptional Regulation by VENTX	R-HSA-8853884	1.219746e-01	0.914
PIP3 activates AKT signaling	R-HSA-1257604	1.283795e-01	0.892
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.256582e-01	0.901
Unwinding of DNA	R-HSA-176974	1.254478e-01	0.902
CDC6 association with the ORC:origin complex	R-HSA-68689	1.966839e-01	0.706
Bicarbonate transporters	R-HSA-425381	1.729278e-01	0.762
Ionotropic activity of kainate receptors	R-HSA-451306	1.729278e-01	0.762
Regulation of FZD by ubiquitination	R-HSA-4641263	1.888533e-01	0.724
Phase 0 - rapid depolarisation	R-HSA-5576892	1.375608e-01	0.862
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.297884e-01	0.887
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	1.148794e-01	0.940
Interleukin-1 signaling	R-HSA-9020702	1.155577e-01	0.937
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.077661e-01	0.968
CLEC7A (Dectin-1) signaling	R-HSA-5607764	1.383314e-01	0.859
Signal Transduction	R-HSA-162582	1.187444e-01	0.925
Suppression of apoptosis	R-HSA-9635465	1.729278e-01	0.762
Non-integrin membrane-ECM interactions	R-HSA-3000171	1.472438e-01	0.832
Adrenoceptors	R-HSA-390696	1.037815e-01	0.984
Transport to the Golgi and subsequent modification	R-HSA-948021	1.458271e-01	0.836
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.155885e-01	0.937
Signaling by PTK6	R-HSA-8848021	1.155885e-01	0.937
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.306126e-01	0.884
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	1.484244e-01	0.828
Basigin interactions	R-HSA-210991	1.295208e-01	0.888
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.185115e-01	0.926
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.905680e-01	0.720
G1/S DNA Damage Checkpoints	R-HSA-69615	1.155885e-01	0.937
Signaling by FGFR2	R-HSA-5654738	1.212956e-01	0.916
Generic Transcription Pathway	R-HSA-212436	1.196410e-01	0.922
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	1.185115e-01	0.926
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.605723e-01	0.794
Degradation of beta-catenin by the destruction complex	R-HSA-195253	1.785670e-01	0.748
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.661027e-01	0.780
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	1.256582e-01	0.901
Regulation of the apoptosome activity	R-HSA-9627069	1.485690e-01	0.828
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	1.295208e-01	0.888
Signaling by PDGFR in disease	R-HSA-9671555	1.446865e-01	0.840
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	1.077661e-01	0.968
PCP/CE pathway	R-HSA-4086400	1.741594e-01	0.759
Cellular response to chemical stress	R-HSA-9711123	1.677994e-01	0.775
Formation of apoptosome	R-HSA-111458	1.485690e-01	0.828
Cytochrome c-mediated apoptotic response	R-HSA-111461	1.983094e-01	0.703
Assembly Of The HIV Virion	R-HSA-175474	1.446865e-01	0.840
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	1.077661e-01	0.968
Potential therapeutics for SARS	R-HSA-9679191	1.441908e-01	0.841
Pre-NOTCH Transcription and Translation	R-HSA-1912408	1.491546e-01	0.826
Sensory processing of sound	R-HSA-9659379	1.836305e-01	0.736
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	1.219746e-01	0.914
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	1.781499e-01	0.749
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.966839e-01	0.706
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.688804e-01	0.772
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	1.446865e-01	0.840
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	1.781499e-01	0.749
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	1.781499e-01	0.749
MHC class II antigen presentation	R-HSA-2132295	1.142709e-01	0.942
Glycogen synthesis	R-HSA-3322077	1.151250e-01	0.939
Regulation of BACH1 activity	R-HSA-9708530	1.497117e-01	0.825
Glycogen storage diseases	R-HSA-3229121	1.888533e-01	0.724
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	1.595145e-01	0.797
Assembly of Viral Components at the Budding Site	R-HSA-168316	1.604352e-01	0.795
Signaling by Interleukins	R-HSA-449147	1.991037e-01	0.701
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	2.033373e-01	0.692
Developmental Biology	R-HSA-1266738	2.037746e-01	0.691
Ion transport by P-type ATPases	R-HSA-936837	2.048695e-01	0.689
Transcriptional regulation by RUNX2	R-HSA-8878166	2.059286e-01	0.686
Attenuation phase	R-HSA-3371568	2.074971e-01	0.683
RNA Polymerase III Transcription Termination	R-HSA-73980	2.095293e-01	0.679
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	2.095293e-01	0.679
PKA activation in glucagon signalling	R-HSA-164378	2.095293e-01	0.679
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.095293e-01	0.679
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.106808e-01	0.676
G-protein beta:gamma signalling	R-HSA-397795	2.106808e-01	0.676
Regulation of necroptotic cell death	R-HSA-5675482	2.106808e-01	0.676
TNF signaling	R-HSA-75893	2.106974e-01	0.676
Signaling by FGFR1	R-HSA-5654736	2.106974e-01	0.676
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	2.106974e-01	0.676
VEGFR2 mediated cell proliferation	R-HSA-5218921	2.119986e-01	0.674
Sema4D in semaphorin signaling	R-HSA-400685	2.119986e-01	0.674
Downstream TCR signaling	R-HSA-202424	2.163589e-01	0.665
Signaling by ERBB4	R-HSA-1236394	2.205339e-01	0.657
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.218946e-01	0.654
Beta-catenin independent WNT signaling	R-HSA-3858494	2.237703e-01	0.650
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.245058e-01	0.649
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	2.245058e-01	0.649
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.245058e-01	0.649
Repression of WNT target genes	R-HSA-4641265	2.245058e-01	0.649
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.281799e-01	0.642
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.281799e-01	0.642
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.281799e-01	0.642
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.308064e-01	0.637
Death Receptor Signaling	R-HSA-73887	2.316597e-01	0.635
Autointegration results in viral DNA circles	R-HSA-177539	2.337932e-01	0.631
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.337932e-01	0.631
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.337932e-01	0.631
Negative regulation of MAPK pathway	R-HSA-5675221	2.366304e-01	0.626
Selenoamino acid metabolism	R-HSA-2408522	2.388851e-01	0.622
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	2.431281e-01	0.614
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	2.431281e-01	0.614
NOD1/2 Signaling Pathway	R-HSA-168638	2.431281e-01	0.614
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	2.431281e-01	0.614
Regulation of RAS by GAPs	R-HSA-5658442	2.435363e-01	0.613
EPHA-mediated growth cone collapse	R-HSA-3928663	2.488291e-01	0.604
CD28 dependent PI3K/Akt signaling	R-HSA-389357	2.488291e-01	0.604
RNA Polymerase I Transcription Termination	R-HSA-73863	2.488291e-01	0.604
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	2.488291e-01	0.604
Frs2-mediated activation	R-HSA-170968	2.513183e-01	0.600
Formation of ATP by chemiosmotic coupling	R-HSA-163210	2.525832e-01	0.598
Co-inhibition by CTLA4	R-HSA-389513	2.525832e-01	0.598
Protein hydroxylation	R-HSA-9629569	2.525832e-01	0.598
Extra-nuclear estrogen signaling	R-HSA-9009391	2.578048e-01	0.589
PERK regulates gene expression	R-HSA-381042	2.598745e-01	0.585
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.598745e-01	0.585
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	2.634155e-01	0.579
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	2.634277e-01	0.579
Interactions of Tat with host cellular proteins	R-HSA-176034	2.634277e-01	0.579
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	2.634277e-01	0.579
Defective PGM1 causes PGM1-CDG	R-HSA-5609974	2.634277e-01	0.579
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.634277e-01	0.579
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	2.634277e-01	0.579
IKBKB deficiency causes SCID	R-HSA-5602636	2.634277e-01	0.579
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	2.634277e-01	0.579
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.634277e-01	0.579
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	2.634277e-01	0.579
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	2.634277e-01	0.579
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	2.634277e-01	0.579
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.634277e-01	0.579
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	2.642218e-01	0.578
ABC transporter disorders	R-HSA-5619084	2.660357e-01	0.575
Telomere Extension By Telomerase	R-HSA-171319	2.678234e-01	0.572
Activation of kainate receptors upon glutamate binding	R-HSA-451326	2.678234e-01	0.572
MECP2 regulates transcription factors	R-HSA-9022707	2.712564e-01	0.567
MET activates PI3K/AKT signaling	R-HSA-8851907	2.712564e-01	0.567
RUNX3 regulates WNT signaling	R-HSA-8951430	2.712564e-01	0.567
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	2.712564e-01	0.567
Disinhibition of SNARE formation	R-HSA-114516	2.712564e-01	0.567
Cation-coupled Chloride cotransporters	R-HSA-426117	2.712564e-01	0.567
CHL1 interactions	R-HSA-447041	2.712564e-01	0.567
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	2.712564e-01	0.567
IFNG signaling activates MAPKs	R-HSA-9732724	2.712564e-01	0.567
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	2.712564e-01	0.567
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.712564e-01	0.567
Uptake and actions of bacterial toxins	R-HSA-5339562	2.716812e-01	0.566
Viral Messenger RNA Synthesis	R-HSA-168325	2.747581e-01	0.561
MAP kinase activation	R-HSA-450294	2.747581e-01	0.561
Regulation of RUNX2 expression and activity	R-HSA-8939902	2.747581e-01	0.561
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.747602e-01	0.561
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	2.747602e-01	0.561
RET signaling	R-HSA-8853659	2.769123e-01	0.558
Regulation of KIT signaling	R-HSA-1433559	2.785599e-01	0.555
mRNA Capping	R-HSA-72086	2.871211e-01	0.542
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.893829e-01	0.539
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.979536e-01	0.526
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	3.019964e-01	0.520
RNA Polymerase III Chain Elongation	R-HSA-73780	3.060568e-01	0.514
Signaling by Activin	R-HSA-1502540	3.060568e-01	0.514
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	3.066612e-01	0.513
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	3.066612e-01	0.513
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	3.086568e-01	0.511
phospho-PLA2 pathway	R-HSA-111995	3.086568e-01	0.511
Activated NTRK2 signals through PI3K	R-HSA-9028335	3.086568e-01	0.511
Sodium/Proton exchangers	R-HSA-425986	3.086568e-01	0.511
RSK activation	R-HSA-444257	3.086568e-01	0.511
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	3.116906e-01	0.506
RIPK1-mediated regulated necrosis	R-HSA-5213460	3.116906e-01	0.506
SLC-mediated transport of inorganic anions	R-HSA-9958790	3.116906e-01	0.506
Diseases of DNA repair	R-HSA-9675135	3.142961e-01	0.503
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	3.199310e-01	0.495
FGFR2 alternative splicing	R-HSA-6803529	3.199310e-01	0.495
Signaling by FGFR	R-HSA-190236	3.228206e-01	0.491
Transcriptional Regulation by MECP2	R-HSA-8986944	3.248084e-01	0.488
Signaling by ALK	R-HSA-201556	3.293461e-01	0.482
Cellular response to hypoxia	R-HSA-1234174	3.295226e-01	0.482
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	3.336493e-01	0.477
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	3.336493e-01	0.477
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	3.336493e-01	0.477
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	3.336493e-01	0.477
HCMV Late Events	R-HSA-9610379	3.338421e-01	0.476
Defective PAPSS2 causes SEMD-PA	R-HSA-3560796	3.348060e-01	0.475
Defective ALG9 causes CDG-1l	R-HSA-4720454	3.348060e-01	0.475
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.348060e-01	0.475
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	3.348060e-01	0.475
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	3.348060e-01	0.475
TGFBR2 Kinase Domain Mutants in Cancer	R-HSA-3645790	3.348060e-01	0.475
Regulation of cortical dendrite branching	R-HSA-8985801	3.348060e-01	0.475
Loss of Function of TGFBR2 in Cancer	R-HSA-3642278	3.348060e-01	0.475
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.348060e-01	0.475
Antagonism of Activin by Follistatin	R-HSA-2473224	3.348060e-01	0.475
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	R-HSA-9708296	3.348060e-01	0.475
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.425183e-01	0.465
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.425183e-01	0.465
Antigen processing-Cross presentation	R-HSA-1236975	3.425183e-01	0.465
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	3.427427e-01	0.465
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	3.427427e-01	0.465
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	3.456552e-01	0.461
ARMS-mediated activation	R-HSA-170984	3.456552e-01	0.461
Calcineurin activates NFAT	R-HSA-2025928	3.456552e-01	0.461
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	3.456552e-01	0.461
ALK mutants bind TKIs	R-HSA-9700645	3.456552e-01	0.461
MASTL Facilitates Mitotic Progression	R-HSA-2465910	3.456552e-01	0.461
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	3.456552e-01	0.461
Respiratory syncytial virus genome replication	R-HSA-9834752	3.456552e-01	0.461
Co-stimulation by CD28	R-HSA-389356	3.466299e-01	0.460
Generation of second messenger molecules	R-HSA-202433	3.471235e-01	0.460
Glycogen metabolism	R-HSA-8982491	3.471235e-01	0.460
Protein-protein interactions at synapses	R-HSA-6794362	3.516827e-01	0.454
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.535288e-01	0.452
TRAF3-dependent IRF activation pathway	R-HSA-918233	3.611920e-01	0.442
Acetylcholine regulates insulin secretion	R-HSA-399997	3.611920e-01	0.442
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	3.611920e-01	0.442
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	3.611920e-01	0.442
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	3.611920e-01	0.442
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.655916e-01	0.437
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.655916e-01	0.437
Nuclear RNA decay	R-HSA-9930044	3.661464e-01	0.436
Peroxisomal protein import	R-HSA-9033241	3.755827e-01	0.425
Extension of Telomeres	R-HSA-180786	3.755827e-01	0.425
Deadenylation-dependent mRNA decay	R-HSA-429914	3.755827e-01	0.425
Amino acid transport across the plasma membrane	R-HSA-352230	3.755827e-01	0.425
MAPK3 (ERK1) activation	R-HSA-110056	3.819783e-01	0.418
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.819783e-01	0.418
Apoptosis induced DNA fragmentation	R-HSA-140342	3.819783e-01	0.418
EGFR Transactivation by Gastrin	R-HSA-2179392	3.819783e-01	0.418
Signal attenuation	R-HSA-74749	3.819783e-01	0.418
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.819783e-01	0.418
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	3.821637e-01	0.418
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	3.821637e-01	0.418
Inositol phosphate metabolism	R-HSA-1483249	3.868957e-01	0.412
Polymerase switching on the C-strand of the telomere	R-HSA-174411	3.883987e-01	0.411
Acyl chain remodelling of PS	R-HSA-1482801	3.883987e-01	0.411
PI3K events in ERBB2 signaling	R-HSA-1963642	3.885542e-01	0.411
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	3.885542e-01	0.411
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.885542e-01	0.411
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.885542e-01	0.411
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.885542e-01	0.411
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	3.885542e-01	0.411
Uptake and function of anthrax toxins	R-HSA-5210891	3.885542e-01	0.411
Post-translational protein modification	R-HSA-597592	3.912258e-01	0.408
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	3.980982e-01	0.400
MET activates PTPN11	R-HSA-8865999	3.992711e-01	0.399
3-Methylcrotonyl-CoA carboxylase deficiency	R-HSA-9909438	3.992711e-01	0.399
Adrenaline signalling through Alpha-2 adrenergic receptor	R-HSA-392023	3.992711e-01	0.399
Activation of BIM and translocation to mitochondria	R-HSA-111446	3.992711e-01	0.399
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.992711e-01	0.399
Interleukin-17 signaling	R-HSA-448424	4.002753e-01	0.398
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	4.007864e-01	0.397
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	4.035203e-01	0.394
RAF activation	R-HSA-5673000	4.059698e-01	0.392
Myogenesis	R-HSA-525793	4.110907e-01	0.386
Signaling by FLT3 fusion proteins	R-HSA-9703465	4.110907e-01	0.386
Suppression of phagosomal maturation	R-HSA-9637687	4.110907e-01	0.386
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	4.145881e-01	0.382
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	4.145881e-01	0.382
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.156194e-01	0.381
Mismatch Repair	R-HSA-5358508	4.156194e-01	0.381
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	4.156194e-01	0.381
Polo-like kinase mediated events	R-HSA-156711	4.156194e-01	0.381
vRNP Assembly	R-HSA-192905	4.174098e-01	0.379
Metabolism of proteins	R-HSA-392499	4.186181e-01	0.378
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.278929e-01	0.369
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.287846e-01	0.368
Infectious disease	R-HSA-5663205	4.312171e-01	0.365
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.316878e-01	0.365
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	4.318146e-01	0.365
Processive synthesis on the C-strand of the telomere	R-HSA-174414	4.335997e-01	0.363
Cristae formation	R-HSA-8949613	4.335997e-01	0.363
Signaling by FGFR2 IIIa TM	R-HSA-8851708	4.422849e-01	0.354
Rap1 signalling	R-HSA-392517	4.422849e-01	0.354
E2F mediated regulation of DNA replication	R-HSA-113510	4.422849e-01	0.354
Lysosome Vesicle Biogenesis	R-HSA-432720	4.454561e-01	0.351
GPVI-mediated activation cascade	R-HSA-114604	4.454561e-01	0.351
ERKs are inactivated	R-HSA-202670	4.517815e-01	0.345
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.517815e-01	0.345
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	4.517815e-01	0.345
Reduction of cytosolic Ca++ levels	R-HSA-418359	4.517815e-01	0.345
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	4.517815e-01	0.345
Sodium/Calcium exchangers	R-HSA-425561	4.517815e-01	0.345
Platelet Aggregation (Plug Formation)	R-HSA-76009	4.541624e-01	0.343
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.574922e-01	0.340
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.574922e-01	0.340
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.574922e-01	0.340
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	4.574922e-01	0.340
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.574922e-01	0.340
Defective LFNG causes SCDO3	R-HSA-5083630	4.574922e-01	0.340
Regulation of gap junction activity	R-HSA-191650	4.574922e-01	0.340
NADE modulates death signalling	R-HSA-205025	4.574922e-01	0.340
Mitochondrial biogenesis	R-HSA-1592230	4.655033e-01	0.332
Interleukin-1 family signaling	R-HSA-446652	4.673159e-01	0.330
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	4.684614e-01	0.329
Regulation of pyruvate metabolism	R-HSA-9861718	4.717315e-01	0.326
Signaling by TGFBR3	R-HSA-9839373	4.717315e-01	0.326
Hemostasis	R-HSA-109582	4.722330e-01	0.326
Protein localization	R-HSA-9609507	4.771406e-01	0.321
Signaling by Erythropoietin	R-HSA-9006335	4.778267e-01	0.321
Platelet calcium homeostasis	R-HSA-418360	4.778267e-01	0.321
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.778267e-01	0.321
Elastic fibre formation	R-HSA-1566948	4.842530e-01	0.315
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	4.849661e-01	0.314
Polymerase switching	R-HSA-69091	4.849661e-01	0.314
Leading Strand Synthesis	R-HSA-69109	4.849661e-01	0.314
Trafficking and processing of endosomal TLR	R-HSA-1679131	4.849661e-01	0.314
RUNX3 regulates p14-ARF	R-HSA-8951936	4.849661e-01	0.314
OAS antiviral response	R-HSA-8983711	4.849661e-01	0.314
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.891385e-01	0.311
Lagging Strand Synthesis	R-HSA-69186	4.940721e-01	0.306
SLC-mediated transport of amino acids	R-HSA-9958863	4.964158e-01	0.304
SHC1 events in ERBB2 signaling	R-HSA-1250196	4.994377e-01	0.302
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.018540e-01	0.299
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.032964e-01	0.298
RAS processing	R-HSA-9648002	5.032964e-01	0.298
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	5.032964e-01	0.298
Plasma lipoprotein clearance	R-HSA-8964043	5.032964e-01	0.298
Metal ion SLC transporters	R-HSA-425410	5.063556e-01	0.296
G2 Phase	R-HSA-68911	5.100738e-01	0.292
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.100738e-01	0.292
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.100738e-01	0.292
Defective F9 activation	R-HSA-9673221	5.100738e-01	0.292
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.100738e-01	0.292
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.100738e-01	0.292
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.100738e-01	0.292
Activation of AKT2	R-HSA-165158	5.100738e-01	0.292
Toxicity of botulinum toxin type G (botG)	R-HSA-5250989	5.100738e-01	0.292
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.100738e-01	0.292
Regulated Necrosis	R-HSA-5218859	5.111527e-01	0.291
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	5.168709e-01	0.287
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.168709e-01	0.287
Formation of axial mesoderm	R-HSA-9796292	5.168709e-01	0.287
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.168709e-01	0.287
Platelet Adhesion to exposed collagen	R-HSA-75892	5.168709e-01	0.287
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	5.168709e-01	0.287
Replication of the SARS-CoV-1 genome	R-HSA-9682706	5.168709e-01	0.287
Transmission across Chemical Synapses	R-HSA-112315	5.200721e-01	0.284
Molecules associated with elastic fibres	R-HSA-2129379	5.206518e-01	0.283
Diseases of Immune System	R-HSA-5260271	5.220578e-01	0.282
Diseases associated with the TLR signaling cascade	R-HSA-5602358	5.220578e-01	0.282
Nuclear signaling by ERBB4	R-HSA-1251985	5.220578e-01	0.282
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	5.414292e-01	0.266
TP53 Regulates Metabolic Genes	R-HSA-5628897	5.421842e-01	0.266
RAF-independent MAPK1/3 activation	R-HSA-112409	5.433473e-01	0.265
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	5.474322e-01	0.262
Signaling by FGFR4 in disease	R-HSA-5655291	5.474322e-01	0.262
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	5.474322e-01	0.262
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.575618e-01	0.254
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.575618e-01	0.254
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.575618e-01	0.254
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	5.575618e-01	0.254
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	5.575618e-01	0.254
Signaling by MAPK mutants	R-HSA-9652817	5.575618e-01	0.254
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	5.575618e-01	0.254
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.575618e-01	0.254
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.575618e-01	0.254
PDE3B signalling	R-HSA-165160	5.575618e-01	0.254
Cam-PDE 1 activation	R-HSA-111957	5.575618e-01	0.254
PKB-mediated events	R-HSA-109703	5.575618e-01	0.254
Phosphorylation of Emi1	R-HSA-176417	5.575618e-01	0.254
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.575618e-01	0.254
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.575618e-01	0.254
Release of apoptotic factors from the mitochondria	R-HSA-111457	5.575618e-01	0.254
Sodium-coupled phosphate cotransporters	R-HSA-427652	5.575618e-01	0.254
Orexin and neuropeptides FF and QRFP bind to their respective receptors	R-HSA-389397	5.575618e-01	0.254
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.575618e-01	0.254
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	5.575618e-01	0.254
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	5.575618e-01	0.254
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	5.575618e-01	0.254
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	5.575618e-01	0.254
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.575618e-01	0.254
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	5.586169e-01	0.253
Signaling by FGFR1 in disease	R-HSA-5655302	5.586169e-01	0.253
Translation of Structural Proteins	R-HSA-9683701	5.586169e-01	0.253
Integrin signaling	R-HSA-354192	5.617355e-01	0.250
FGFR1 mutant receptor activation	R-HSA-1839124	5.617355e-01	0.250
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.617355e-01	0.250
C-type lectin receptors (CLRs)	R-HSA-5621481	5.638969e-01	0.249
FOXO-mediated transcription	R-HSA-9614085	5.653794e-01	0.248
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.669140e-01	0.246
Syndecan interactions	R-HSA-3000170	5.669140e-01	0.246
Growth hormone receptor signaling	R-HSA-982772	5.669140e-01	0.246
Processive synthesis on the lagging strand	R-HSA-69183	5.766108e-01	0.239
Telomere C-strand synthesis initiation	R-HSA-174430	5.766108e-01	0.239
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	5.766108e-01	0.239
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	5.766108e-01	0.239
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	5.815410e-01	0.235
Miscellaneous transport and binding events	R-HSA-5223345	5.815410e-01	0.235
Glucagon signaling in metabolic regulation	R-HSA-163359	5.815410e-01	0.235
Ca2+ pathway	R-HSA-4086398	5.823808e-01	0.235
CD209 (DC-SIGN) signaling	R-HSA-5621575	5.897175e-01	0.229
Signaling by FGFR in disease	R-HSA-1226099	5.960373e-01	0.225
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.996642e-01	0.222
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.004493e-01	0.222
Erythropoietin activates STAT5	R-HSA-9027283	6.004493e-01	0.222
STAT5 Activation	R-HSA-9645135	6.004493e-01	0.222
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.004493e-01	0.222
G2/M DNA replication checkpoint	R-HSA-69478	6.004493e-01	0.222
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	6.004493e-01	0.222
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	6.004493e-01	0.222
Defective CHST3 causes SEDCJD	R-HSA-3595172	6.004493e-01	0.222
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.004493e-01	0.222
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	6.004493e-01	0.222
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	6.004493e-01	0.222
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	6.004493e-01	0.222
Neurofascin interactions	R-HSA-447043	6.004493e-01	0.222
Abacavir transmembrane transport	R-HSA-2161517	6.004493e-01	0.222
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.004493e-01	0.222
Nef and signal transduction	R-HSA-164944	6.004493e-01	0.222
VLDL assembly	R-HSA-8866423	6.004493e-01	0.222
HDL clearance	R-HSA-8964011	6.004493e-01	0.222
eNOS activation	R-HSA-203615	6.008209e-01	0.221
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	6.043876e-01	0.219
Virus Assembly and Release	R-HSA-168268	6.043876e-01	0.219
Iron uptake and transport	R-HSA-917937	6.094696e-01	0.215
Proteasome assembly	R-HSA-9907900	6.106850e-01	0.214
Tight junction interactions	R-HSA-420029	6.117318e-01	0.213
TGFBR3 expression	R-HSA-9839394	6.117318e-01	0.213
Interleukin-7 signaling	R-HSA-1266695	6.117318e-01	0.213
Signalling to ERKs	R-HSA-187687	6.195546e-01	0.208
Somitogenesis	R-HSA-9824272	6.272257e-01	0.203
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	6.272257e-01	0.203
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	6.307601e-01	0.200
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	6.329383e-01	0.199
Detoxification of Reactive Oxygen Species	R-HSA-3299685	6.345898e-01	0.198
Adipogenesis	R-HSA-9843745	6.357628e-01	0.197
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.391819e-01	0.194
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.391819e-01	0.194
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.391819e-01	0.194
Defective CHSY1 causes TPBS	R-HSA-3595177	6.391819e-01	0.194
DAG1 core M1 glycosylations	R-HSA-8932506	6.391819e-01	0.194
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.391819e-01	0.194
PTK6 Expression	R-HSA-8849473	6.391819e-01	0.194
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.391819e-01	0.194
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.391819e-01	0.194
LDL remodeling	R-HSA-8964041	6.391819e-01	0.194
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.391819e-01	0.194
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	6.391819e-01	0.194
Circadian clock	R-HSA-9909396	6.455034e-01	0.190
Toll-like Receptor Cascades	R-HSA-168898	6.493909e-01	0.187
Signaling by NTRK2 (TRKB)	R-HSA-9006115	6.533254e-01	0.185
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.557396e-01	0.183
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	6.557396e-01	0.183
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	6.557396e-01	0.183
Specification of primordial germ cells	R-HSA-9827857	6.557396e-01	0.183
Replication of the SARS-CoV-2 genome	R-HSA-9694686	6.557396e-01	0.183
Regulation of insulin secretion	R-HSA-422356	6.718353e-01	0.173
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	6.723347e-01	0.172
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	6.728876e-01	0.172
Signaling by MET	R-HSA-6806834	6.729510e-01	0.172
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.741618e-01	0.171
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.741618e-01	0.171
DAG1 core M2 glycosylations	R-HSA-8932504	6.741618e-01	0.171
Signaling by MRAS-complex mutants	R-HSA-9660537	6.741618e-01	0.171
MET receptor recycling	R-HSA-8875656	6.741618e-01	0.171
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	6.741618e-01	0.171
Toxicity of botulinum toxin type B (botB)	R-HSA-5250958	6.741618e-01	0.171
Co-stimulation by ICOS	R-HSA-9927354	6.741618e-01	0.171
TGFBR3 PTM regulation	R-HSA-9839383	6.741618e-01	0.171
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	6.741618e-01	0.171
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	6.741618e-01	0.171
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	6.741618e-01	0.171
Interleukin-23 signaling	R-HSA-9020933	6.741618e-01	0.171
GPER1 signaling	R-HSA-9634597	6.742161e-01	0.171
NGF-stimulated transcription	R-HSA-9031628	6.742161e-01	0.171
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	6.784155e-01	0.169
G beta:gamma signalling through PLC beta	R-HSA-418217	6.793483e-01	0.168
Platelet sensitization by LDL	R-HSA-432142	6.793483e-01	0.168
Presynaptic function of Kainate receptors	R-HSA-500657	6.793483e-01	0.168
Synaptic adhesion-like molecules	R-HSA-8849932	6.793483e-01	0.168
Nephron development	R-HSA-9831926	6.793483e-01	0.168
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.793483e-01	0.168
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	6.887576e-01	0.162
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	6.887576e-01	0.162
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	6.916245e-01	0.160
Regulation of gene expression in beta cells	R-HSA-210745	6.916245e-01	0.160
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.919692e-01	0.160
Pre-NOTCH Processing in Golgi	R-HSA-1912420	7.016171e-01	0.154
PI-3K cascade:FGFR3	R-HSA-5654710	7.016171e-01	0.154
Impaired BRCA2 binding to PALB2	R-HSA-9709603	7.016171e-01	0.154
Germ layer formation at gastrulation	R-HSA-9754189	7.016171e-01	0.154
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	7.016171e-01	0.154
Signaling by FGFR2 in disease	R-HSA-5655253	7.032706e-01	0.153
Formation of paraxial mesoderm	R-HSA-9793380	7.038547e-01	0.153
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.055264e-01	0.151
Lipophagy	R-HSA-9613354	7.057524e-01	0.151
MAPK1 (ERK2) activation	R-HSA-112411	7.057524e-01	0.151
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.057524e-01	0.151
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.057524e-01	0.151
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.057524e-01	0.151
Regulation of CDH11 gene transcription	R-HSA-9762293	7.057524e-01	0.151
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.057524e-01	0.151
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.057524e-01	0.151
Regulated proteolysis of p75NTR	R-HSA-193692	7.057524e-01	0.151
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.057524e-01	0.151
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.057524e-01	0.151
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	7.078546e-01	0.150
DAP12 signaling	R-HSA-2424491	7.095408e-01	0.149
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	7.095408e-01	0.149
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.095408e-01	0.149
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	7.095408e-01	0.149
Heme signaling	R-HSA-9707616	7.165810e-01	0.145
Resolution of Abasic Sites (AP sites)	R-HSA-73933	7.198271e-01	0.143
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.225839e-01	0.141
PI-3K cascade:FGFR4	R-HSA-5654720	7.225839e-01	0.141
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.225839e-01	0.141
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	7.225839e-01	0.141
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	7.225839e-01	0.141
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	7.225839e-01	0.141
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	7.225839e-01	0.141
VxPx cargo-targeting to cilium	R-HSA-5620916	7.225839e-01	0.141
Common Pathway of Fibrin Clot Formation	R-HSA-140875	7.225839e-01	0.141
Formation of definitive endoderm	R-HSA-9823730	7.225839e-01	0.141
Signaling by NODAL	R-HSA-1181150	7.225839e-01	0.141
Neddylation	R-HSA-8951664	7.262977e-01	0.139
Downstream signal transduction	R-HSA-186763	7.266452e-01	0.139
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	7.289244e-01	0.137
Cardiac conduction	R-HSA-5576891	7.318866e-01	0.136
MET activates RAP1 and RAC1	R-HSA-8875555	7.342819e-01	0.134
Binding and entry of HIV virion	R-HSA-173107	7.342819e-01	0.134
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	7.342819e-01	0.134
PI3K/AKT activation	R-HSA-198203	7.342819e-01	0.134
CASP4 inflammasome assembly	R-HSA-9948001	7.342819e-01	0.134
Defective factor IX causes hemophilia B	R-HSA-9668250	7.342819e-01	0.134
Interleukin-27 signaling	R-HSA-9020956	7.342819e-01	0.134
Maturation of spike protein	R-HSA-9683686	7.342819e-01	0.134
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	7.342819e-01	0.134
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	7.360721e-01	0.133
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	7.394852e-01	0.131
Insulin receptor signalling cascade	R-HSA-74751	7.408843e-01	0.130
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.422918e-01	0.129
ERK/MAPK targets	R-HSA-198753	7.422918e-01	0.129
TNFR1-induced proapoptotic signaling	R-HSA-5357786	7.422918e-01	0.129
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	7.422918e-01	0.129
RSV-host interactions	R-HSA-9833110	7.425645e-01	0.129
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.485408e-01	0.126
Cytosolic tRNA aminoacylation	R-HSA-379716	7.485408e-01	0.126
Asparagine N-linked glycosylation	R-HSA-446203	7.545540e-01	0.122
Cardiogenesis	R-HSA-9733709	7.584697e-01	0.120
DAG1 core M3 glycosylations	R-HSA-8932505	7.600468e-01	0.119
Chylomicron assembly	R-HSA-8963888	7.600468e-01	0.119
RHOBTB3 ATPase cycle	R-HSA-9706019	7.600468e-01	0.119
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.600468e-01	0.119
Dissolution of Fibrin Clot	R-HSA-75205	7.600468e-01	0.119
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	7.607877e-01	0.119
Serine metabolism	R-HSA-977347	7.607877e-01	0.119
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	7.607877e-01	0.119
Translation of Structural Proteins	R-HSA-9694635	7.613974e-01	0.118
Signaling by SCF-KIT	R-HSA-1433557	7.620272e-01	0.118
Integrin cell surface interactions	R-HSA-216083	7.715929e-01	0.113
G alpha (12/13) signalling events	R-HSA-416482	7.715929e-01	0.113
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	7.732229e-01	0.112
PI-3K cascade:FGFR1	R-HSA-5654689	7.781214e-01	0.109
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.781214e-01	0.109
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.781214e-01	0.109
Neurotoxicity of clostridium toxins	R-HSA-168799	7.781214e-01	0.109
Signaling by KIT in disease	R-HSA-9669938	7.781214e-01	0.109
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.781214e-01	0.109
NRAGE signals death through JNK	R-HSA-193648	7.793361e-01	0.108
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	7.814649e-01	0.107
DS-GAG biosynthesis	R-HSA-2022923	7.833148e-01	0.106
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.833148e-01	0.106
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	7.833148e-01	0.106
PI3K events in ERBB4 signaling	R-HSA-1250342	7.833148e-01	0.106
Proton-coupled monocarboxylate transport	R-HSA-433692	7.833148e-01	0.106
Plasmalogen biosynthesis	R-HSA-75896	7.833148e-01	0.106
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	7.833148e-01	0.106
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.872289e-01	0.104
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.873014e-01	0.104
Developmental Cell Lineages	R-HSA-9734767	7.897400e-01	0.103
Adaptive Immune System	R-HSA-1280218	7.917523e-01	0.101
Free fatty acids regulate insulin secretion	R-HSA-400451	7.943443e-01	0.100
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.010687e-01	0.096
Negative regulation of the PI3K/AKT network	R-HSA-199418	8.011844e-01	0.096
Maple Syrup Urine Disease	R-HSA-9865114	8.043277e-01	0.095
GRB2 events in EGFR signaling	R-HSA-179812	8.043277e-01	0.095
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	8.043277e-01	0.095
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.043277e-01	0.095
Signaling by LTK	R-HSA-9842663	8.043277e-01	0.095
Interleukin-35 Signalling	R-HSA-8984722	8.043277e-01	0.095
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.043277e-01	0.095
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	8.095087e-01	0.092
Complex III assembly	R-HSA-9865881	8.095087e-01	0.092
Plasma lipoprotein assembly	R-HSA-8963898	8.095087e-01	0.092
RUNX2 regulates bone development	R-HSA-8941326	8.130875e-01	0.090
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.130875e-01	0.090
FGFR2 mutant receptor activation	R-HSA-1839126	8.130875e-01	0.090
tRNA Aminoacylation	R-HSA-379724	8.210748e-01	0.086
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.210748e-01	0.086
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	8.220729e-01	0.085
Microbial factors inhibit CASP4 activity	R-HSA-9956593	8.233041e-01	0.084
CD28 dependent Vav1 pathway	R-HSA-389359	8.233041e-01	0.084
Interleukin-6 signaling	R-HSA-1059683	8.233041e-01	0.084
PI-3K cascade:FGFR2	R-HSA-5654695	8.236673e-01	0.084
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	8.236673e-01	0.084
Glycogen breakdown (glycogenolysis)	R-HSA-70221	8.236673e-01	0.084
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	8.236673e-01	0.084
Formation of the nephric duct	R-HSA-9830364	8.236673e-01	0.084
TRAF6 mediated IRF7 activation	R-HSA-933541	8.249867e-01	0.084
IRS-related events triggered by IGF1R	R-HSA-2428928	8.304523e-01	0.081
Aquaporin-mediated transport	R-HSA-445717	8.304523e-01	0.081
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.311733e-01	0.080
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	8.368725e-01	0.077
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	8.368725e-01	0.077
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	8.368725e-01	0.077
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.368725e-01	0.077
NCAM signaling for neurite out-growth	R-HSA-375165	8.394256e-01	0.076
Mitochondrial protein import	R-HSA-1268020	8.394256e-01	0.076
Signaling by PDGF	R-HSA-186797	8.394256e-01	0.076
Removal of the Flap Intermediate	R-HSA-69166	8.404412e-01	0.075
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	8.404412e-01	0.075
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.404412e-01	0.075
CRMPs in Sema3A signaling	R-HSA-399956	8.404412e-01	0.075
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.404412e-01	0.075
Hydrolysis of LPC	R-HSA-1483115	8.404412e-01	0.075
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.404412e-01	0.075
Non-canonical inflammasome activation	R-HSA-9686114	8.404412e-01	0.075
HDL assembly	R-HSA-8963896	8.404412e-01	0.075
Signal regulatory protein family interactions	R-HSA-391160	8.404412e-01	0.075
Acyl chain remodeling of CL	R-HSA-1482798	8.404412e-01	0.075
Zinc transporters	R-HSA-435354	8.404412e-01	0.075
PI3K Cascade	R-HSA-109704	8.411257e-01	0.075
Ion channel transport	R-HSA-983712	8.487012e-01	0.071
Insulin processing	R-HSA-264876	8.491761e-01	0.071
Signaling by FGFR3 in disease	R-HSA-5655332	8.491761e-01	0.071
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.491761e-01	0.071
Maturation of hRSV A proteins	R-HSA-9828806	8.491761e-01	0.071
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	8.492123e-01	0.071
Erythropoietin activates RAS	R-HSA-9027284	8.559171e-01	0.068
SHC1 events in EGFR signaling	R-HSA-180336	8.559171e-01	0.068
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.559171e-01	0.068
DCC mediated attractive signaling	R-HSA-418885	8.559171e-01	0.068
Transport and metabolism of PAPS	R-HSA-174362	8.559171e-01	0.068
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	8.559171e-01	0.068
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	8.559171e-01	0.068
Protein lipoylation	R-HSA-9857492	8.559171e-01	0.068
Biotin transport and metabolism	R-HSA-196780	8.559171e-01	0.068
DNA Damage Reversal	R-HSA-73942	8.559171e-01	0.068
IGF1R signaling cascade	R-HSA-2428924	8.562012e-01	0.067
Pyruvate metabolism	R-HSA-70268	8.563485e-01	0.067
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.606287e-01	0.065
Pyroptosis	R-HSA-5620971	8.606287e-01	0.065
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	8.640250e-01	0.063
tRNA processing	R-HSA-72306	8.646495e-01	0.063
Disorders of transmembrane transporters	R-HSA-5619115	8.671039e-01	0.062
Disease	R-HSA-1643685	8.692663e-01	0.061
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.698928e-01	0.061
Defective GALNT3 causes HFTC	R-HSA-5083625	8.698928e-01	0.061
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.698928e-01	0.061
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.698928e-01	0.061
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.698928e-01	0.061
Fructose catabolism	R-HSA-70350	8.698928e-01	0.061
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	8.698928e-01	0.061
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.698928e-01	0.061
Attachment and Entry	R-HSA-9678110	8.698928e-01	0.061
Atorvastatin ADME	R-HSA-9754706	8.698928e-01	0.061
Downstream signaling of activated FGFR3	R-HSA-5654708	8.712795e-01	0.060
Intra-Golgi traffic	R-HSA-6811438	8.751778e-01	0.058
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.791546e-01	0.056
Downstream signaling of activated FGFR4	R-HSA-5654716	8.811763e-01	0.055
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.811763e-01	0.055
Interleukin-37 signaling	R-HSA-9008059	8.811763e-01	0.055
G beta:gamma signalling through CDC42	R-HSA-8964616	8.825136e-01	0.054
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	8.825136e-01	0.054
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	8.825136e-01	0.054
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	8.825136e-01	0.054
GRB2 events in ERBB2 signaling	R-HSA-1963640	8.825136e-01	0.054
Fibronectin matrix formation	R-HSA-1566977	8.825136e-01	0.054
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	8.825136e-01	0.054
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	8.825136e-01	0.054
Passive transport by Aquaporins	R-HSA-432047	8.825136e-01	0.054
Synthesis of PG	R-HSA-1483148	8.825136e-01	0.054
Galactose catabolism	R-HSA-70370	8.825136e-01	0.054
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	8.825136e-01	0.054
Coenzyme A biosynthesis	R-HSA-196783	8.825136e-01	0.054
tRNA modification in the mitochondrion	R-HSA-6787450	8.825136e-01	0.054
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	8.825136e-01	0.054
Neuronal System	R-HSA-112316	8.869058e-01	0.052
Class I MHC mediated antigen processing & presentation	R-HSA-983169	8.896255e-01	0.051
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.903652e-01	0.050
Extracellular matrix organization	R-HSA-1474244	8.935055e-01	0.049
Signaling by Insulin receptor	R-HSA-74752	8.935819e-01	0.049
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	8.935819e-01	0.049
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.935819e-01	0.049
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	8.939108e-01	0.049
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	8.939108e-01	0.049
Regulation of NPAS4 gene expression	R-HSA-9768759	8.939108e-01	0.049
IRS-mediated signalling	R-HSA-112399	8.968690e-01	0.047
FCERI mediated NF-kB activation	R-HSA-2871837	8.974682e-01	0.047
DAP12 interactions	R-HSA-2172127	8.987593e-01	0.046
Amine ligand-binding receptors	R-HSA-375280	8.987593e-01	0.046
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.988902e-01	0.046
Mitochondrial protein degradation	R-HSA-9837999	9.040296e-01	0.044
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.042031e-01	0.044
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	9.042031e-01	0.044
Tie2 Signaling	R-HSA-210993	9.042031e-01	0.044
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	9.067937e-01	0.042
Regulation of beta-cell development	R-HSA-186712	9.092585e-01	0.041
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.093202e-01	0.041
Interferon gamma signaling	R-HSA-877300	9.109075e-01	0.041
Pyrimidine biosynthesis	R-HSA-500753	9.134973e-01	0.039
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.134973e-01	0.039
The NLRP3 inflammasome	R-HSA-844456	9.134973e-01	0.039
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.134973e-01	0.039
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.134973e-01	0.039
Methionine salvage pathway	R-HSA-1237112	9.134973e-01	0.039
Specification of the neural plate border	R-HSA-9834899	9.134973e-01	0.039
Diseases of hemostasis	R-HSA-9671793	9.134973e-01	0.039
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.134973e-01	0.039
Maturation of nucleoprotein	R-HSA-9694631	9.134973e-01	0.039
Other interleukin signaling	R-HSA-449836	9.134973e-01	0.039
Resolution of D-Loop Structures	R-HSA-5693537	9.141160e-01	0.039
Acyl chain remodelling of PC	R-HSA-1482788	9.141160e-01	0.039
Effects of PIP2 hydrolysis	R-HSA-114508	9.141160e-01	0.039
Glutamate and glutamine metabolism	R-HSA-8964539	9.141160e-01	0.039
Diseases of carbohydrate metabolism	R-HSA-5663084	9.145755e-01	0.039
Metabolism of polyamines	R-HSA-351202	9.149427e-01	0.039
Signaling by NTRK1 (TRKA)	R-HSA-187037	9.160108e-01	0.038
Gastrulation	R-HSA-9758941	9.170862e-01	0.038
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.208955e-01	0.036
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.208955e-01	0.036
Hyaluronan metabolism	R-HSA-2142845	9.208955e-01	0.036
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.208955e-01	0.036
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.218903e-01	0.035
Acyl chain remodelling of PI	R-HSA-1482922	9.218903e-01	0.035
Creatine metabolism	R-HSA-71288	9.218903e-01	0.035
Acyl chain remodelling of PE	R-HSA-1482839	9.271685e-01	0.033
Downstream signaling of activated FGFR2	R-HSA-5654696	9.271685e-01	0.033
Downstream signaling of activated FGFR1	R-HSA-5654687	9.271685e-01	0.033
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.272672e-01	0.033
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.294695e-01	0.032
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.294695e-01	0.032
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.294695e-01	0.032
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.294695e-01	0.032
Zygotic genome activation (ZGA)	R-HSA-9819196	9.294695e-01	0.032
Acyl chain remodelling of PG	R-HSA-1482925	9.294695e-01	0.032
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.309807e-01	0.031
Triglyceride catabolism	R-HSA-163560	9.329694e-01	0.030
Azathioprine ADME	R-HSA-9748787	9.342538e-01	0.030
Immune System	R-HSA-168256	9.353888e-01	0.029
CS-GAG biosynthesis	R-HSA-2022870	9.363136e-01	0.029
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.363136e-01	0.029
Attachment and Entry	R-HSA-9694614	9.363136e-01	0.029
Ribavirin ADME	R-HSA-9755088	9.363136e-01	0.029
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.375388e-01	0.028
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	9.424939e-01	0.026
Fructose metabolism	R-HSA-5652084	9.424939e-01	0.026
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.424939e-01	0.026
Kidney development	R-HSA-9830369	9.465680e-01	0.024
Amino acids regulate mTORC1	R-HSA-9639288	9.473226e-01	0.024
Nucleotide biosynthesis	R-HSA-8956320	9.473226e-01	0.024
Integration of energy metabolism	R-HSA-163685	9.479799e-01	0.023
Termination of O-glycan biosynthesis	R-HSA-977068	9.480749e-01	0.023
Interleukin receptor SHC signaling	R-HSA-912526	9.480749e-01	0.023
Formation of the ureteric bud	R-HSA-9830674	9.480749e-01	0.023
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.480749e-01	0.023
Organic anion transport by SLCO transporters	R-HSA-879518	9.480749e-01	0.023
ABC transporters in lipid homeostasis	R-HSA-1369062	9.480749e-01	0.023
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.480749e-01	0.023
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.490411e-01	0.023
Signaling by NTRKs	R-HSA-166520	9.497698e-01	0.022
Interferon alpha/beta signaling	R-HSA-909733	9.505900e-01	0.022
Tryptophan catabolism	R-HSA-71240	9.520753e-01	0.021
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.520753e-01	0.021
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	9.529273e-01	0.021
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.531144e-01	0.021
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.531144e-01	0.021
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.531144e-01	0.021
Mitochondrial RNA degradation	R-HSA-9836573	9.531144e-01	0.021
Interleukin-6 family signaling	R-HSA-6783589	9.531144e-01	0.021
Cytoprotection by HMOX1	R-HSA-9707564	9.540223e-01	0.020
G alpha (z) signalling events	R-HSA-418597	9.546454e-01	0.020
Paracetamol ADME	R-HSA-9753281	9.546454e-01	0.020
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.559674e-01	0.020
Maturation of spike protein	R-HSA-9694548	9.559674e-01	0.020
COPII-mediated vesicle transport	R-HSA-204005	9.564819e-01	0.019
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.574140e-01	0.019
Leishmania phagocytosis	R-HSA-9664417	9.574140e-01	0.019
Parasite infection	R-HSA-9664407	9.574140e-01	0.019
Hyaluronan degradation	R-HSA-2160916	9.576652e-01	0.019
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.576652e-01	0.019
Laminin interactions	R-HSA-3000157	9.576652e-01	0.019
ECM proteoglycans	R-HSA-3000178	9.593894e-01	0.018
Scavenging by Class A Receptors	R-HSA-3000480	9.595557e-01	0.018
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.595557e-01	0.018
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.595557e-01	0.018
Stimuli-sensing channels	R-HSA-2672351	9.602107e-01	0.018
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.607339e-01	0.017
Dectin-2 family	R-HSA-5621480	9.610070e-01	0.017
Synthesis of PA	R-HSA-1483166	9.610070e-01	0.017
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.617745e-01	0.017
TRP channels	R-HSA-3295583	9.617745e-01	0.017
Urea cycle	R-HSA-70635	9.617745e-01	0.017
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.617745e-01	0.017
Sphingolipid catabolism	R-HSA-9845614	9.617745e-01	0.017
Abacavir ADME	R-HSA-2161522	9.617745e-01	0.017
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.620987e-01	0.017
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.654851e-01	0.015
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	9.654851e-01	0.015
Triglyceride biosynthesis	R-HSA-75109	9.654851e-01	0.015
TBC/RABGAPs	R-HSA-8854214	9.659087e-01	0.015
Triglyceride metabolism	R-HSA-8979227	9.665227e-01	0.015
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.665227e-01	0.015
Insulin receptor recycling	R-HSA-77387	9.688357e-01	0.014
Prednisone ADME	R-HSA-9757110	9.688357e-01	0.014
Inflammasomes	R-HSA-622312	9.688357e-01	0.014
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.712957e-01	0.013
Thyroxine biosynthesis	R-HSA-209968	9.718613e-01	0.012
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.736714e-01	0.012
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.736714e-01	0.012
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.736714e-01	0.012
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	9.745932e-01	0.011
Synthesis of PC	R-HSA-1483191	9.758565e-01	0.011
Cargo concentration in the ER	R-HSA-5694530	9.770601e-01	0.010
DAG1 glycosylations	R-HSA-8931838	9.792876e-01	0.009
Rab regulation of trafficking	R-HSA-9007101	9.793139e-01	0.009
Platelet homeostasis	R-HSA-418346	9.802971e-01	0.009
SLC transporter disorders	R-HSA-5619102	9.807481e-01	0.008
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.812989e-01	0.008
Recycling of bile acids and salts	R-HSA-159418	9.812989e-01	0.008
Branched-chain amino acid catabolism	R-HSA-70895	9.829684e-01	0.007
The phototransduction cascade	R-HSA-2514856	9.829684e-01	0.007
CS/DS degradation	R-HSA-2024101	9.831150e-01	0.007
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.831150e-01	0.007
Heme degradation	R-HSA-189483	9.831150e-01	0.007
Degradation of the extracellular matrix	R-HSA-1474228	9.831987e-01	0.007
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.847548e-01	0.007
Signal amplification	R-HSA-392518	9.847548e-01	0.007
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.858451e-01	0.006
Transferrin endocytosis and recycling	R-HSA-917977	9.862355e-01	0.006
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.862355e-01	0.006
FCERI mediated MAPK activation	R-HSA-2871796	9.866740e-01	0.006
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.869322e-01	0.006
Metabolism of cofactors	R-HSA-8978934	9.869322e-01	0.006
NCAM1 interactions	R-HSA-419037	9.887796e-01	0.005
Collagen chain trimerization	R-HSA-8948216	9.887796e-01	0.005
Metabolism of folate and pterines	R-HSA-196757	9.887796e-01	0.005
tRNA processing in the mitochondrion	R-HSA-6785470	9.898696e-01	0.004
MET promotes cell motility	R-HSA-8875878	9.898696e-01	0.004
Neurotransmitter release cycle	R-HSA-112310	9.904694e-01	0.004
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.908271e-01	0.004
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.908537e-01	0.004
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.908537e-01	0.004
Pentose phosphate pathway	R-HSA-71336	9.908537e-01	0.004
Leishmania infection	R-HSA-9658195	9.909115e-01	0.004
Parasitic Infection Pathways	R-HSA-9824443	9.909115e-01	0.004
rRNA processing in the mitochondrion	R-HSA-8868766	9.917423e-01	0.004
Interleukin-2 family signaling	R-HSA-451927	9.917423e-01	0.004
Collagen formation	R-HSA-1474290	9.934777e-01	0.003
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	9.935855e-01	0.003
Leishmania parasite growth and survival	R-HSA-9664433	9.938104e-01	0.003
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.938104e-01	0.003
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.939230e-01	0.003
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	9.945136e-01	0.002
Innate Immune System	R-HSA-168249	9.949529e-01	0.002
Netrin-1 signaling	R-HSA-373752	9.950467e-01	0.002
Methylation	R-HSA-156581	9.950467e-01	0.002
Surfactant metabolism	R-HSA-5683826	9.950467e-01	0.002
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.955261e-01	0.002
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.962671e-01	0.002
Plasma lipoprotein remodeling	R-HSA-8963899	9.967095e-01	0.001
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.967216e-01	0.001
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.969019e-01	0.001
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.969957e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.970293e-01	0.001
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.973521e-01	0.001
Complex IV assembly	R-HSA-9864848	9.975789e-01	0.001
Citric acid cycle (TCA cycle)	R-HSA-71403	9.980278e-01	0.001
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.980278e-01	0.001
Formation of the cornified envelope	R-HSA-6809371	9.983312e-01	0.001
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.983583e-01	0.001
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.983919e-01	0.001
SLC-mediated transport of organic anions	R-HSA-9955298	9.985025e-01	0.001
Interleukin-10 signaling	R-HSA-6783783	9.985025e-01	0.001
Metabolism of amine-derived hormones	R-HSA-209776	9.985483e-01	0.001
PPARA activates gene expression	R-HSA-1989781	9.987113e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.988650e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.990937e-01	0.000
Collagen degradation	R-HSA-1442490	9.991297e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.992908e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.993056e-01	0.000
SLC-mediated transmembrane transport	R-HSA-425407	9.993318e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.993598e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.995749e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.995992e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.996433e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.996504e-01	0.000
Glycosphingolipid catabolism	R-HSA-9840310	9.996536e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.996873e-01	0.000
FCGR activation	R-HSA-2029481	9.996910e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.997438e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.997452e-01	0.000
Aspirin ADME	R-HSA-9749641	9.997453e-01	0.000
ROS and RNS production in phagocytes	R-HSA-1222556	9.997701e-01	0.000
Transport of small molecules	R-HSA-382551	9.997756e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.997877e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.997877e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.998241e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.998399e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.998407e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.998416e-01	0.000
Nuclear Receptor transcription pathway	R-HSA-383280	9.998474e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.998474e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.998549e-01	0.000
PI Metabolism	R-HSA-1483255	9.998793e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.998953e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999070e-01	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999153e-01	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	9.999164e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999175e-01	0.000
Sulfur amino acid metabolism	R-HSA-1614635	9.999393e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999434e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999532e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999602e-01	0.000
Sensory perception of taste	R-HSA-9717189	9.999620e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999665e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999774e-01	0.000
Metabolism of nucleotides	R-HSA-15869	9.999908e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.999955e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999973e-01	0.000
O-linked glycosylation	R-HSA-5173105	9.999976e-01	0.000
Keratinization	R-HSA-6805567	9.999988e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999992e-01	0.000
Glycosphingolipid metabolism	R-HSA-1660662	9.999992e-01	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	9.999993e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999993e-01	0.000
Drug ADME	R-HSA-9748784	9.999996e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999996e-01	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999997e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999997e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999999e-01	0.000
Complement cascade	R-HSA-166658	9.999999e-01	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000