PDHK1

Normalized values from positional scanning peptide array
TYR version of PSPA with Y as phospho-acceptor
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O00141 S422 GPS6 SGK1 SGK PDsVLVTAsVKEAAEAFLGFsYAPPTDSFL___________
O00141 T256 GPS6 SGK1 SGK IVLTDFGLCKENIEHNsTtstFCGtPEyLAPEVLHKQPYDR
O15530 S241 GPS6 PDPK1 PDK1 ITDFGTAKVLSPESKQARANsFVGtAQYVSPELLTEKSACK
O15530 S25 GPS6 PDPK1 PDK1 TSQLyDAVPIQSSVVLCSCPsPSMVRTQtESstPPGIPGGS
O15530 S393 GPS6 PDPK1 PDK1 yGNyDNLLSQFGCMQVSSSSssHsLsASDTGLPQRSGsNIE
O15530 S396 GPS6 PDPK1 PDK1 yDNLLSQFGCMQVSSSSssHsLsASDTGLPQRSGsNIEQYI
O15530 S410 GPS6 PDPK1 PDK1 SSSssHsLsASDTGLPQRSGsNIEQYIHDLDSNSFELDLQF
O15530 T513 GPS6 PDPK1 PDK1 VLKGEIPWSQELRPEAKNFKtFFVHTPNRTYYLMDPSGNAH
O43707 Y878 Sugiyama ACTN4 DKNFITAEELRRELPPDQAEyCIARMAPyQGPDAVPGALDy
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60664 Y95 Sugiyama PLIN3 M6PRBP1 TIP47 VsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQPTE
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05106 T777 GPS6 ITGB3 GP3A EEERARAKWDtANNPLyKEAtstFtNItyRGt_________
P05106 T779 GPS6|iPTMNet ITGB3 GP3A ERARAKWDtANNPLyKEAtstFtNItyRGt___________
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S470 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08559 S232 iPTMNet|PSP PDHA1 PHE1A ALWKLPCIFICENNRYGMGtsVERAAAsTDYYKRGDFIPGL
P08559 S293 GPS6|ELM|iPTMNet|PSP PDHA1 PHE1A CRSGKGPILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsK
P08559 S300 GPS6|ELM|iPTMNet|PSP PDHA1 PHE1A ILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsKsDPIMLL
P0DPH7 S48 Sugiyama TUBA3C TUBA2 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P12814 Y859 Sugiyama ACTN1 DKNyITMDELRRELPPDQAEyCIARMAPYTGPDSVPGALDY
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13667 S379 Sugiyama PDIA4 ERP70 ERP72 QPEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGH
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23443 S427 GPS6 RPS6KB1 STK14A VFLGFtYVAPSVLESVKEKFsFEPKIRsPRRFIGsPRtPVs
P23443 T252 GPS6 RPS6KB1 STK14A VKLTDFGLCKEsIHDGTVtHtFCGTIEYMAPEILMRSGHNR
P23443 T390 iPTMNet RPS6KB1 STK14A KPLLQsEEDVsQFDSKFtRQtPVDsPDDstLsEsANQVFLG
P23443 T412 GPS6 RPS6KB1 STK14A VDsPDDstLsEsANQVFLGFtYVAPSVLESVKEKFsFEPKI
P26232 T657 Sugiyama CTNNA2 CAPR EDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P28066 Y8 Sugiyama PSMA5 _____________MFLTRsEyDRGVNtFsPEGRLFQVEyAI
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29803 S230 PSP PDHA2 PDHAL ALWKLPCVFICENNLYGMGTsTERAAASPDYYKRGNFIPGL
P29803 S291 PSP PDHA2 PDHAL CRSGKGPILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsK
P29803 S298 PSP PDHA2 PDHAL ILMELQTYRyHGHsMsDPGVsyRtREEIQEVRsKRDPIIIL
P31749 S473 GPS6 AKT1 PKB RAC DQDDSMECVDSERRPHFPQFsysAsGtA_____________
P31749 T308 GPS6 AKT1 PKB RAC IKITDFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGR
P31751 T309 GPS6 AKT2 IKITDFGLCKEGISDGATMKtFCGtPEyLAPEVLEDNDyGR
P31943 Y266 Sugiyama HNRNPH1 HNRPH HNRPH1 yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P35221 T658 Sugiyama CTNNA1 LDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQLPQ
P36507 S226 GPS6 MAP2K2 MEK2 MKK2 PRKMK2 GEIKLCDFGVsGQLIDsMANsFVGtRSYMAPERLQGTHYSV
P48643 S270 Sugiyama CCT5 CCTE KIAA0098 ILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMIQ
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55060 S342 Sugiyama CSE1L CAS XPO2 ASVCERPHYKNLFEDQNtLtsICEKVIVPNMEFRAADEEAF
P55795 Y266 Sugiyama HNRNPH2 FTP3 HNRPH2 YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P68363 S48 Sugiyama TUBA1B HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q02156 T566 GPS6 PRKCE PKCE CKLADFGMCKEGILNGVTTTtFCGTPDyIAPEILQELEYGP
Q02750 S222 GPS6 MAP2K1 MEK1 PRKMK1 GEIKLCDFGVsGQLIDsMANsFVGtRSYMsPERLQGTHYSV
Q05513 T410 GPS6 PRKCZ PKC2 IKLTDYGMCKEGLGPGDTTstFCGTPNyIAPEILRGEEyGF
Q05655 T507 GPS6 PRKCD PKCD IKIADFGMCKENIFGEsRAstFCGtPDyIAPEILQGLKyTF
Q13153 T423 GPS6 PAK1 VKLTDFGFCAQITPEQSKRstMVGTPYWMAPEVVTRKAYGP
Q15118 S27 Sugiyama PDK1 PDHK1 LRGAALAGPGPGLRAAGFsRsFsSDSGSSPASERGVPGQVD
Q15118 S29 Sugiyama PDK1 PDHK1 GAALAGPGPGLRAAGFsRsFsSDSGSSPASERGVPGQVDFy
Q15118 S396 Sugiyama PDK1 PDHK1 YSLEGYGTDAVIYIKALsTDsIERLPVyNKAAWKHyNtNHE
Q15118 S424 Sugiyama PDK1 PDHK1 NKAAWKHyNtNHEADDWCVPsREPKDMTTFRSA________
Q15118 S67 Sugiyama PDK1 PDHK1 DFyARFSPSPLSMKQFLDFGsVNACEKTSFMFLRQELPVRL
Q15118 T413 Sugiyama PDK1 PDHK1 sTDsIERLPVyNKAAWKHyNtNHEADDWCVPsREPKDMTTF
Q15118 Y136 Sugiyama PDK1 PDHK1 QSLQELLDFKDKSAEDAKAIyDFTDTVIRIRNRHNDVIPTM
Q15118 Y368 Sugiyama PDK1 PDHK1 RAVPLAGFGYGLPISRLYAQyFQGDLKLYSLEGYGTDAVIY
Q15118 Y403 Sugiyama PDK1 PDHK1 TDAVIYIKALsTDsIERLPVyNKAAWKHyNtNHEADDWCVP
Q15118 Y411 Sugiyama PDK1 PDHK1 ALsTDsIERLPVyNKAAWKHyNtNHEADDWCVPsREPKDMT
Q15118 Y49 Sugiyama PDK1 PDHK1 sSDSGSSPASERGVPGQVDFyARFSPSPLSMKQFLDFGsVN
Q15418 S221 GPS6 RPS6KA1 MAPKAPK1A RSK1 IKLTDFGLSKEAIDHEKKAysFCGtVEYMAPEVVNRQGHSH
Q16512 T774 GPS6 PKN1 PAK1 PKN PRK1 PRKCL1 VKIADFGLCKEGMGyGDRtstFCGtPEFLAPEVLTDTSYTR
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16513 T816 GPS6 PKN2 PRK2 PRKCL2 VKIADFGLCKEGMGYGDRtstFCGtPEFLAPEVLTETSYTR
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q6PEY2 S48 Sugiyama TUBA3E HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71U36 S48 Sugiyama TUBA1A TUBA3 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q96BR1 T320 GPS6 SGK3 CISK SGKL VVLTDFGLCKEGIAISDTTTtFCGTPEYLAPEVIRKQPYDN
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q99683 T838 GPS6 MAP3K5 ASK1 MAPKKK5 MEKK5 LKISDFGtSKRLAGINPCTEtFTGtLQyMAPEIIDKGPRGY
Q9BQE3 S48 Sugiyama TUBA1C TUBA6 HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9UPQ0 S207 Sugiyama LIMCH1 KIAA1102 RsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVVLRGssD
Q9Y243 T305 GPS6 AKT3 PKBG IKITDFGLCKEGITDAATMKtFCGtPEyLAPEVLEDNDyGR
Q9Y639 Y220 Sugiyama NPTN SDFR1 SDR1 NMEYRINKPRAEDsGEyHCVyHFVsAPKANATIEVKAAPDI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.957176e-08 7.708 0 0
Cell Cycle R-HSA-1640170 3.369650e-08 7.472 0 0
Cell Cycle, Mitotic R-HSA-69278 1.165647e-07 6.933 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.217760e-07 6.654 0 0
Signaling by ALK in cancer R-HSA-9700206 2.217760e-07 6.654 0 0
Axon guidance R-HSA-422475 2.144073e-07 6.669 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.429025e-07 6.265 0 0
Nervous system development R-HSA-9675108 7.861205e-07 6.105 0 0
Mitotic Prometaphase R-HSA-68877 1.144945e-06 5.941 0 0
G2/M Transition R-HSA-69275 1.727993e-06 5.762 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.658644e-06 5.116 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 8.680470e-06 5.061 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.185925e-05 4.926 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.150563e-05 4.939 0 0
M Phase R-HSA-68886 1.557850e-05 4.807 0 0
Oncogene Induced Senescence R-HSA-2559585 1.786213e-05 4.748 0 0
HSF1 activation R-HSA-3371511 2.445658e-05 4.612 0 0
Autophagy R-HSA-9612973 2.398813e-05 4.620 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.043725e-05 4.517 0 0
Death Receptor Signaling R-HSA-73887 3.626400e-05 4.441 0 0
Signal Transduction R-HSA-162582 3.520219e-05 4.453 1 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.027820e-05 4.395 0 0
Post NMDA receptor activation events R-HSA-438064 4.160396e-05 4.381 0 0
Centrosome maturation R-HSA-380287 4.603215e-05 4.337 0 0
Membrane Trafficking R-HSA-199991 4.632181e-05 4.334 0 0
Selective autophagy R-HSA-9663891 5.012072e-05 4.300 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.500854e-05 4.260 0 0
Apoptotic execution phase R-HSA-75153 5.800585e-05 4.237 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.105875e-05 4.148 0 0
Aggrephagy R-HSA-9646399 7.795873e-05 4.108 0 0
Macroautophagy R-HSA-1632852 8.270413e-05 4.082 0 0
Interleukin-37 signaling R-HSA-9008059 9.666049e-05 4.015 0 0
FLT3 Signaling R-HSA-9607240 1.018705e-04 3.992 0 0
Apoptosis R-HSA-109581 1.032838e-04 3.986 0 0
Cell Cycle Checkpoints R-HSA-69620 1.367821e-04 3.864 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.496676e-04 3.825 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.496676e-04 3.825 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.621981e-04 3.790 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.602783e-04 3.795 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.673392e-04 3.776 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.047449e-04 3.689 0 0
Kinesins R-HSA-983189 2.012336e-04 3.696 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.174386e-04 3.663 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.467279e-04 3.608 0 0
Separation of Sister Chromatids R-HSA-2467813 2.458195e-04 3.609 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.707256e-04 3.567 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.726498e-04 3.564 0 0
NRAGE signals death through JNK R-HSA-193648 5.446398e-04 3.264 0 0
EPH-Ephrin signaling R-HSA-2682334 5.625573e-04 3.250 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.029934e-04 3.220 0 0
Attenuation phase R-HSA-3371568 6.247118e-04 3.204 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 6.850869e-04 3.164 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.850869e-04 3.164 0 0
Late endosomal microautophagy R-HSA-9615710 7.112223e-04 3.148 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.838014e-04 3.106 0 0
Mitotic Anaphase R-HSA-68882 7.728455e-04 3.112 0 0
Cellular response to heat stress R-HSA-3371556 8.263520e-04 3.083 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.474978e-04 3.072 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.818693e-04 3.055 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.153520e-03 2.938 0 0
HSF1-dependent transactivation R-HSA-3371571 1.202434e-03 2.920 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.207556e-03 2.918 0 0
MAPK family signaling cascades R-HSA-5683057 1.270493e-03 2.896 0 0
Programmed Cell Death R-HSA-5357801 1.288316e-03 2.890 0 0
Regulation of CDH1 Function R-HSA-9764561 1.543419e-03 2.812 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.514186e-03 2.820 0 0
L1CAM interactions R-HSA-373760 1.589966e-03 2.799 0 0
Regulation of TP53 Activity R-HSA-5633007 1.609012e-03 2.793 0 0
NF-kB is activated and signals survival R-HSA-209560 1.710998e-03 2.767 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.756343e-03 2.755 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.926949e-03 2.715 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.015933e-03 2.696 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.015933e-03 2.696 0 0
Translesion synthesis by REV1 R-HSA-110312 2.015933e-03 2.696 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.958804e-03 2.708 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.928661e-03 2.715 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.015933e-03 2.696 0 0
Ephrin signaling R-HSA-3928664 2.165822e-03 2.664 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.823565e-03 2.549 0 0
Translesion synthesis by POLI R-HSA-5656121 2.823565e-03 2.549 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.775665e-03 2.557 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.650304e-03 2.577 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.517167e-03 2.599 0 0
Signaling by ROBO receptors R-HSA-376176 2.640225e-03 2.578 0 0
Dual Incision in GG-NER R-HSA-5696400 3.001468e-03 2.523 0 0
Mitophagy R-HSA-5205647 3.001468e-03 2.523 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.001468e-03 2.523 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.065302e-03 2.514 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.065302e-03 2.514 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.277657e-03 2.484 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.327159e-03 2.478 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.707190e-03 2.431 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.579047e-03 2.446 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.535010e-03 2.452 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.535010e-03 2.452 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.497698e-03 2.456 0 0
Regulation of PTEN localization R-HSA-8948747 3.579047e-03 2.446 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.747832e-03 2.426 0 0
Translesion synthesis by POLK R-HSA-5655862 3.867588e-03 2.413 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.013301e-03 2.396 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.602948e-03 2.337 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.453510e-03 2.351 0 0
FLT3 signaling in disease R-HSA-9682385 4.520406e-03 2.345 0 0
RET signaling R-HSA-8853659 4.520406e-03 2.345 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.520406e-03 2.345 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.795652e-03 2.319 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.795652e-03 2.319 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.084299e-03 2.294 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 5.063268e-03 2.296 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.226137e-03 2.282 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.226137e-03 2.282 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.030886e-03 2.298 0 0
Signaling by Hippo R-HSA-2028269 5.191779e-03 2.285 0 0
Regulation of KIT signaling R-HSA-1433559 5.084299e-03 2.294 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.485082e-03 2.261 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.485082e-03 2.261 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.629484e-03 2.250 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 5.629484e-03 2.250 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.629484e-03 2.250 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.072216e-03 2.217 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.072216e-03 2.217 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.072216e-03 2.217 0 0
G2/M Checkpoints R-HSA-69481 5.870561e-03 2.231 0 0
Signaling by RAS mutants R-HSA-6802949 6.072216e-03 2.217 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.827608e-03 2.235 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.827608e-03 2.235 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.173900e-03 2.209 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 6.237430e-03 2.205 0 0
TNF signaling R-HSA-75893 6.322357e-03 2.199 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 6.610748e-03 2.180 0 0
Signaling by AMER1 mutants R-HSA-4839748 6.610748e-03 2.180 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.610748e-03 2.180 0 0
p75NTR signals via NF-kB R-HSA-193639 6.931628e-03 2.159 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.608663e-03 2.180 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.859364e-03 2.164 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.889636e-03 2.162 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.106172e-03 2.148 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.156732e-03 2.145 0 0
Recycling pathway of L1 R-HSA-437239 7.156732e-03 2.145 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.328663e-03 2.135 0 0
TRP channels R-HSA-3295583 7.579616e-03 2.120 0 0
Cell-Cell communication R-HSA-1500931 7.874564e-03 2.104 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 8.221029e-03 2.085 0 0
p75NTR recruits signalling complexes R-HSA-209543 9.205981e-03 2.036 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 9.205981e-03 2.036 0 0
IRAK1 recruits IKK complex R-HSA-937039 9.205981e-03 2.036 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 9.205981e-03 2.036 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 9.205981e-03 2.036 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 9.205981e-03 2.036 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 9.205981e-03 2.036 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 9.205981e-03 2.036 0 0
Negative regulation of FLT3 R-HSA-9706369 9.245463e-03 2.034 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.966749e-03 2.001 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.966749e-03 2.001 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.761917e-03 2.057 0 0
Translesion Synthesis by POLH R-HSA-110320 8.868154e-03 2.052 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 8.427850e-03 2.074 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.376185e-03 2.028 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.351262e-03 2.029 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.486781e-03 2.023 0 0
Interleukin-1 family signaling R-HSA-446652 9.892572e-03 2.005 0 0
PKR-mediated signaling R-HSA-9833482 1.017792e-02 1.992 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.018773e-02 1.992 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.045347e-02 1.981 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.100562e-02 1.958 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.131804e-02 1.946 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.148438e-02 1.940 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.157127e-02 1.937 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.247788e-02 1.904 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.209079e-02 1.918 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.226266e-02 1.911 0 0
MAP2K and MAPK activation R-HSA-5674135 1.305391e-02 1.884 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.305391e-02 1.884 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.209079e-02 1.918 0 0
Hedgehog 'off' state R-HSA-5610787 1.209237e-02 1.917 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.226266e-02 1.911 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.247788e-02 1.904 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.246711e-02 1.904 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.376206e-02 1.861 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.393631e-02 1.856 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.470227e-02 1.833 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.470227e-02 1.833 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.678658e-02 1.775 0 0
Signaling by APC mutants R-HSA-4839744 1.678658e-02 1.775 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.678658e-02 1.775 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.678658e-02 1.775 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.678658e-02 1.775 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.651304e-02 1.782 0 0
Rab regulation of trafficking R-HSA-9007101 1.673380e-02 1.776 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.651304e-02 1.782 0 0
PECAM1 interactions R-HSA-210990 1.678658e-02 1.775 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.651636e-02 1.782 0 0
Signaling by PTK6 R-HSA-8848021 1.651636e-02 1.782 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.738444e-02 1.760 0 0
Signaling by SCF-KIT R-HSA-1433557 1.771477e-02 1.752 0 0
Signaling by Hedgehog R-HSA-5358351 1.869865e-02 1.728 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.912332e-02 1.718 0 0
Polo-like kinase mediated events R-HSA-156711 1.963119e-02 1.707 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.963119e-02 1.707 0 0
EGFR downregulation R-HSA-182971 1.999976e-02 1.699 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.999976e-02 1.699 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.240709e-02 1.650 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.240709e-02 1.650 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.258383e-02 1.646 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.139302e-02 1.670 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.139302e-02 1.670 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.139302e-02 1.670 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.304732e-02 1.637 0 0
Signaling by NOTCH1 R-HSA-1980143 2.171057e-02 1.663 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.025317e-02 1.694 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.018557e-02 1.695 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.045141e-02 1.689 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.298612e-02 1.639 0 0
Signaling by VEGF R-HSA-194138 2.226536e-02 1.652 0 0
Cilium Assembly R-HSA-5617833 2.106651e-02 1.676 0 0
Cellular responses to stimuli R-HSA-8953897 2.280950e-02 1.642 0 0
Signaling by AXIN mutants R-HSA-4839735 2.258383e-02 1.646 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.170577e-02 1.663 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.025317e-02 1.694 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.240709e-02 1.650 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.352448e-02 1.628 0 0
DAG and IP3 signaling R-HSA-1489509 2.354360e-02 1.628 0 0
Signaling by WNT in cancer R-HSA-4791275 2.367422e-02 1.626 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.385189e-02 1.622 0 0
Calmodulin induced events R-HSA-111933 2.392427e-02 1.621 0 0
CaM pathway R-HSA-111997 2.392427e-02 1.621 0 0
Regulation of signaling by CBL R-HSA-912631 2.444731e-02 1.612 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.542857e-02 1.595 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.542857e-02 1.595 0 0
Signaling by EGFR R-HSA-177929 2.542857e-02 1.595 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.542857e-02 1.595 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.932630e-02 1.533 0 0
Phosphorylation of Emi1 R-HSA-176417 2.932630e-02 1.533 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.959470e-02 1.529 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.959470e-02 1.529 0 0
Phosphorylation of the APC/C R-HSA-176412 2.719218e-02 1.566 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.738350e-02 1.563 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.682038e-02 1.572 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.977254e-02 1.526 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.815067e-02 1.551 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.959470e-02 1.529 0 0
Homology Directed Repair R-HSA-5693538 2.947753e-02 1.531 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.867815e-02 1.542 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.887260e-02 1.540 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.887260e-02 1.540 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.887260e-02 1.540 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.932630e-02 1.533 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.643811e-02 1.578 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.977254e-02 1.526 0 0
Regulated Necrosis R-HSA-5218859 2.950436e-02 1.530 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.918186e-02 1.535 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.637388e-02 1.579 0 0
Cell junction organization R-HSA-446728 2.809416e-02 1.551 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.950436e-02 1.530 0 0
Maturation of protein E R-HSA-9694493 2.932630e-02 1.533 0 0
Maturation of protein E R-HSA-9683683 2.932630e-02 1.533 0 0
G alpha (12/13) signalling events R-HSA-416482 2.682038e-02 1.572 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.003442e-02 1.522 0 0
Nephrin family interactions R-HSA-373753 3.003442e-02 1.522 0 0
CASP8 activity is inhibited R-HSA-5218900 3.089200e-02 1.510 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.107935e-02 1.508 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.107935e-02 1.508 0 0
Signaling by NOTCH4 R-HSA-9013694 3.123987e-02 1.505 0 0
Ca-dependent events R-HSA-111996 3.151889e-02 1.501 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.162888e-02 1.500 0 0
Neurodegenerative Diseases R-HSA-8863678 3.162888e-02 1.500 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.234944e-02 1.490 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.234944e-02 1.490 0 0
DARPP-32 events R-HSA-180024 3.234944e-02 1.490 0 0
Striated Muscle Contraction R-HSA-390522 3.245790e-02 1.489 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.245790e-02 1.489 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.245790e-02 1.489 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.322254e-02 1.479 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.322254e-02 1.479 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.355131e-02 1.474 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 3.403425e-02 1.468 0 0
Activation and oligomerization of BAK protein R-HSA-111452 3.403425e-02 1.468 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.403425e-02 1.468 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.403425e-02 1.468 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.403425e-02 1.468 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.403425e-02 1.468 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.403425e-02 1.468 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.403425e-02 1.468 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.621081e-02 1.441 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.027035e-02 1.395 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.027035e-02 1.395 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.027035e-02 1.395 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.027035e-02 1.395 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.027035e-02 1.395 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.649445e-02 1.438 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.649445e-02 1.438 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.728771e-02 1.428 0 0
DNA Damage Bypass R-HSA-73893 3.931132e-02 1.405 0 0
Signaling by ERBB2 R-HSA-1227986 4.027035e-02 1.395 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.029417e-02 1.395 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.029417e-02 1.395 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.644081e-02 1.438 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.608555e-02 1.443 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.527352e-02 1.453 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.761478e-02 1.425 0 0
Long-term potentiation R-HSA-9620244 3.761478e-02 1.425 0 0
TBC/RABGAPs R-HSA-8854214 3.595758e-02 1.444 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.653455e-02 1.437 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.391804e-02 1.470 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.457488e-02 1.461 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.762190e-02 1.425 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.082517e-02 1.389 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.115332e-02 1.386 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.115332e-02 1.386 0 0
Josephin domain DUBs R-HSA-5689877 4.115332e-02 1.386 0 0
Pexophagy R-HSA-9664873 4.115332e-02 1.386 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.179849e-02 1.379 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.210670e-02 1.376 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 4.210670e-02 1.376 0 0
STAT5 Activation R-HSA-9645135 4.210670e-02 1.376 0 0
Neurofascin interactions R-HSA-447043 4.210670e-02 1.376 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.219879e-02 1.375 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.223120e-02 1.374 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.224174e-02 1.374 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.296702e-02 1.367 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 4.333362e-02 1.363 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.370792e-02 1.359 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.406258e-02 1.356 0 0
Trafficking of AMPA receptors R-HSA-399719 4.410877e-02 1.355 0 0
Budding and maturation of HIV virion R-HSA-162588 4.410877e-02 1.355 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.432969e-02 1.353 0 0
PLC beta mediated events R-HSA-112043 4.479270e-02 1.349 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.555623e-02 1.341 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.645262e-02 1.248 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.645262e-02 1.248 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.645262e-02 1.248 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.645262e-02 1.248 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.645262e-02 1.248 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 5.645262e-02 1.248 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 5.645262e-02 1.248 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.756463e-02 1.240 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.070308e-02 1.295 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.070308e-02 1.295 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.070308e-02 1.295 0 0
PKA activation R-HSA-163615 5.070308e-02 1.295 0 0
PKA activation in glucagon signalling R-HSA-164378 5.070308e-02 1.295 0 0
Notch-HLH transcription pathway R-HSA-350054 5.186962e-02 1.285 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.425913e-02 1.266 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.425913e-02 1.266 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.816596e-02 1.235 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.526529e-02 1.258 0 0
Dual incision in TC-NER R-HSA-6782135 5.810213e-02 1.236 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.810213e-02 1.236 0 0
Signaling by ERBB4 R-HSA-1236394 5.369028e-02 1.270 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.661311e-02 1.247 0 0
Nucleotide Excision Repair R-HSA-5696398 5.576239e-02 1.254 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.648313e-02 1.248 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.966422e-02 1.304 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.713961e-02 1.327 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.186962e-02 1.285 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.959653e-02 1.305 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.959653e-02 1.305 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.796802e-02 1.319 0 0
Platelet sensitization by LDL R-HSA-432142 5.070308e-02 1.295 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 5.242270e-02 1.280 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.961451e-02 1.304 0 0
Vesicle-mediated transport R-HSA-5653656 5.076262e-02 1.294 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.851053e-02 1.314 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 5.070308e-02 1.295 0 0
Transport of connexons to the plasma membrane R-HSA-190872 5.070308e-02 1.295 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.847293e-02 1.233 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.847293e-02 1.233 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.847293e-02 1.233 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.847293e-02 1.233 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.860259e-02 1.232 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.860259e-02 1.232 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.877818e-02 1.231 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.027669e-02 1.220 0 0
Cellular responses to stress R-HSA-2262752 6.034376e-02 1.219 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.049623e-02 1.218 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.071971e-02 1.217 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.122643e-02 1.213 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.122643e-02 1.213 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.139507e-02 1.212 0 0
Platelet degranulation R-HSA-114608 6.140864e-02 1.212 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.144431e-02 1.212 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.719755e-02 1.173 0 0
Translation initiation complex formation R-HSA-72649 6.807163e-02 1.167 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.840393e-02 1.165 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 6.910249e-02 1.161 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.910249e-02 1.161 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.926637e-02 1.159 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.940664e-02 1.159 0 0
Stimuli-sensing channels R-HSA-2672351 6.940664e-02 1.159 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.970648e-02 1.157 0 0
Manipulation of host energy metabolism R-HSA-9636667 6.980422e-02 1.156 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 6.980422e-02 1.156 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 6.980422e-02 1.156 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 6.980422e-02 1.156 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.993369e-02 1.155 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 7.105801e-02 1.148 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 7.105801e-02 1.148 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 7.105801e-02 1.148 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 8.094804e-02 1.092 0 0
NrCAM interactions R-HSA-447038 8.094804e-02 1.092 0 0
IRS activation R-HSA-74713 8.094804e-02 1.092 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 8.094804e-02 1.092 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 8.094804e-02 1.092 0 0
Type I hemidesmosome assembly R-HSA-446107 7.564810e-02 1.121 0 0
Regulation by c-FLIP R-HSA-3371378 7.564810e-02 1.121 0 0
Dimerization of procaspase-8 R-HSA-69416 7.564810e-02 1.121 0 0
Formation of annular gap junctions R-HSA-196025 7.564810e-02 1.121 0 0
Polymerase switching R-HSA-69091 8.297903e-02 1.081 0 0
Leading Strand Synthesis R-HSA-69109 8.297903e-02 1.081 0 0
Regulation of IFNG signaling R-HSA-877312 8.297903e-02 1.081 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.491727e-02 1.071 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.491727e-02 1.071 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.186546e-02 1.143 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.414418e-02 1.075 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.558699e-02 1.122 0 0
RAF activation R-HSA-5673000 7.558699e-02 1.122 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.558699e-02 1.122 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.558699e-02 1.122 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.270165e-02 1.082 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.118169e-02 1.091 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.546557e-02 1.020 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.464110e-02 1.072 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.053116e-02 1.043 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.345698e-02 1.134 0 0
Deubiquitination R-HSA-5688426 7.616406e-02 1.118 0 0
Interferon alpha/beta signaling R-HSA-909733 8.512079e-02 1.070 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 7.204154e-02 1.142 0 0
Mitotic Prophase R-HSA-68875 7.970423e-02 1.099 0 0
TGFBR3 expression R-HSA-9839394 8.193501e-02 1.087 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.414418e-02 1.075 0 0
Stabilization of p53 R-HSA-69541 7.204154e-02 1.142 0 0
Peptide chain elongation R-HSA-156902 7.223132e-02 1.141 0 0
Signaling by TGFB family members R-HSA-9006936 8.636041e-02 1.064 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.297903e-02 1.081 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.384382e-02 1.028 0 0
G-protein mediated events R-HSA-112040 7.959326e-02 1.099 0 0
Semaphorin interactions R-HSA-373755 9.273564e-02 1.033 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.520092e-02 1.070 0 0
DNA Double Strand Break Response R-HSA-5693606 7.959326e-02 1.099 0 0
Degradation of CDH1 R-HSA-9766229 7.214100e-02 1.142 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.212814e-02 1.086 0 0
Negative regulation of MET activity R-HSA-6807004 7.186546e-02 1.143 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.920137e-02 1.050 0 0
Circadian clock R-HSA-9909396 8.953113e-02 1.048 0 0
Glycogen synthesis R-HSA-3322077 7.186546e-02 1.143 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.839954e-02 1.054 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.564810e-02 1.121 0 0
Signaling by TGFBR3 R-HSA-9839373 9.391558e-02 1.027 0 0
Heme signaling R-HSA-9707616 8.495722e-02 1.071 0 0
Glycolysis R-HSA-70171 8.497500e-02 1.071 0 0
Signaling by NOTCH3 R-HSA-9012852 7.515534e-02 1.124 0 0
Diseases of DNA repair R-HSA-9675135 9.391558e-02 1.027 0 0
Sensory processing of sound R-HSA-9659379 8.243492e-02 1.084 0 0
Modulation by Mtb of host immune system R-HSA-9637628 7.564810e-02 1.121 0 0
RUNX2 regulates bone development R-HSA-8941326 9.552364e-02 1.020 0 0
Regulated proteolysis of p75NTR R-HSA-193692 9.623375e-02 1.017 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 9.623375e-02 1.017 0 0
Gap junction degradation R-HSA-190873 9.623375e-02 1.017 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 9.623375e-02 1.017 0 0
ALK mutants bind TKIs R-HSA-9700645 9.623375e-02 1.017 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 9.623375e-02 1.017 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 9.623375e-02 1.017 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 9.630880e-02 1.016 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.754670e-02 1.011 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.754670e-02 1.011 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 9.754670e-02 1.011 0 0
Assembly Of The HIV Virion R-HSA-175474 9.754670e-02 1.011 0 0
Cellular Senescence R-HSA-2559583 9.788589e-02 1.009 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.000572e-01 1.000 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.005393e-01 0.998 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.005393e-01 0.998 0 0
Interleukin-6 signaling R-HSA-1059683 1.005393e-01 0.998 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.005393e-01 0.998 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.005393e-01 0.998 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.010986e-01 0.995 0 0
HIV Life Cycle R-HSA-162587 1.023098e-01 0.990 0 0
UCH proteinases R-HSA-5689603 1.031667e-01 0.986 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.035315e-01 0.985 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.037793e-01 0.984 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.051784e-01 0.978 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.335873e-01 0.874 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.335873e-01 0.874 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.335873e-01 0.874 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.335873e-01 0.874 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.335873e-01 0.874 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.335873e-01 0.874 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.335873e-01 0.874 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.335873e-01 0.874 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.335873e-01 0.874 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.335873e-01 0.874 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.335873e-01 0.874 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.335873e-01 0.874 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.335873e-01 0.874 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.335873e-01 0.874 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.335873e-01 0.874 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.335873e-01 0.874 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.335873e-01 0.874 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.335873e-01 0.874 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.335873e-01 0.874 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.335873e-01 0.874 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.335873e-01 0.874 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.335873e-01 0.874 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.335873e-01 0.874 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.132563e-01 0.946 0 0
Regulation of TP53 Expression R-HSA-6804754 1.132563e-01 0.946 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.132563e-01 0.946 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.132563e-01 0.946 0 0
Diseases of cellular response to stress R-HSA-9675132 1.132563e-01 0.946 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.132563e-01 0.946 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.132563e-01 0.946 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.132563e-01 0.946 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.132563e-01 0.946 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.132563e-01 0.946 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.132563e-01 0.946 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.132563e-01 0.946 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.132563e-01 0.946 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.132563e-01 0.946 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.132563e-01 0.946 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.092073e-01 0.962 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 1.092073e-01 0.962 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 1.092073e-01 0.962 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.092073e-01 0.962 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.092073e-01 0.962 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.092073e-01 0.962 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.406611e-01 0.852 0 0
G2/M DNA replication checkpoint R-HSA-69478 1.406611e-01 0.852 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.191409e-01 0.924 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.191409e-01 0.924 0 0
DCC mediated attractive signaling R-HSA-418885 1.406309e-01 0.852 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.406309e-01 0.852 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.406309e-01 0.852 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.536356e-01 0.814 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.133725e-01 0.945 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.264308e-01 0.898 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.264308e-01 0.898 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.506043e-01 0.822 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.402524e-01 0.853 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.306914e-01 0.884 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.137101e-01 0.944 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.437725e-01 0.842 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.437725e-01 0.842 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 1.437725e-01 0.842 0 0
snRNP Assembly R-HSA-191859 1.081488e-01 0.966 0 0
Metabolism of non-coding RNA R-HSA-194441 1.081488e-01 0.966 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.591001e-01 0.798 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.475509e-01 0.831 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.485814e-01 0.828 0 0
Ribosome-associated quality control R-HSA-9948299 1.318267e-01 0.880 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.486515e-01 0.828 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.535188e-01 0.814 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.591814e-01 0.798 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.065522e-01 0.972 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.437725e-01 0.842 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 1.406611e-01 0.852 0 0
Signal attenuation R-HSA-74749 1.191409e-01 0.924 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.461042e-01 0.835 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.461042e-01 0.835 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.558472e-01 0.807 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.370442e-01 0.863 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.120513e-01 0.951 0 0
Hedgehog 'on' state R-HSA-5632684 1.105946e-01 0.956 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.197936e-01 0.922 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 1.120513e-01 0.951 0 0
Eukaryotic Translation Termination R-HSA-72764 1.354475e-01 0.868 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.218639e-01 0.914 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.361177e-01 0.866 0 0
CREB phosphorylation R-HSA-199920 1.406611e-01 0.852 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.282659e-01 0.892 0 0
Nuclear import of Rev protein R-HSA-180746 1.402524e-01 0.853 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.437725e-01 0.842 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.437725e-01 0.842 0 0
Signaling by FGFR4 R-HSA-5654743 1.218639e-01 0.914 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.182789e-01 0.927 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.426848e-01 0.846 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.061724e-01 0.974 0 0
Signaling by FGFR3 R-HSA-5654741 1.461042e-01 0.835 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.092073e-01 0.962 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.167314e-01 0.933 0 0
PCP/CE pathway R-HSA-4086400 1.196894e-01 0.922 0 0
Interleukin-1 signaling R-HSA-9020702 1.344097e-01 0.872 0 0
MAP kinase activation R-HSA-450294 1.274508e-01 0.895 0 0
Interferon Signaling R-HSA-913531 1.567847e-01 0.805 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.350978e-01 0.869 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.274508e-01 0.895 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.092073e-01 0.962 0 0
Nef and signal transduction R-HSA-164944 1.406611e-01 0.852 0 0
S Phase R-HSA-69242 1.221881e-01 0.913 0 0
G1 Phase R-HSA-69236 1.336863e-01 0.874 0 0
Cyclin D associated events in G1 R-HSA-69231 1.336863e-01 0.874 0 0
Rap1 signalling R-HSA-392517 1.345829e-01 0.871 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.186798e-01 0.926 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.406309e-01 0.852 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.132563e-01 0.946 0 0
Smooth Muscle Contraction R-HSA-445355 1.061724e-01 0.974 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.437725e-01 0.842 0 0
MTOR signalling R-HSA-165159 1.106507e-01 0.956 0 0
Signaling by Leptin R-HSA-2586552 1.191409e-01 0.924 0 0
Syndecan interactions R-HSA-3000170 1.276245e-01 0.894 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.442217e-01 0.841 0 0
HIV Infection R-HSA-162906 1.515991e-01 0.819 0 0
Gap junction trafficking and regulation R-HSA-157858 1.244457e-01 0.905 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.441455e-01 0.841 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.276245e-01 0.894 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.191409e-01 0.924 0 0
MHC class II antigen presentation R-HSA-2132295 1.367005e-01 0.864 0 0
Gap junction trafficking R-HSA-190828 1.336863e-01 0.874 0 0
Signaling by KIT in disease R-HSA-9669938 1.120513e-01 0.951 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.486470e-01 0.828 0 0
Interleukin-12 signaling R-HSA-9020591 1.582730e-01 0.801 0 0
Neurexins and neuroligins R-HSA-6794361 1.598947e-01 0.796 0 0
G1/S Transition R-HSA-69206 1.599864e-01 0.796 0 0
Opioid Signalling R-HSA-111885 1.600872e-01 0.796 0 0
FasL/ CD95L signaling R-HSA-75157 1.617015e-01 0.791 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.617015e-01 0.791 0 0
Axonal growth stimulation R-HSA-209563 1.617015e-01 0.791 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.617015e-01 0.791 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.617015e-01 0.791 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.629192e-01 0.788 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.629192e-01 0.788 0 0
Prolonged ERK activation events R-HSA-169893 1.629192e-01 0.788 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.629192e-01 0.788 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.629192e-01 0.788 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.669259e-01 0.777 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.669259e-01 0.777 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.669259e-01 0.777 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.669259e-01 0.777 0 0
mRNA Splicing R-HSA-72172 1.686341e-01 0.773 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.700737e-01 0.769 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.709930e-01 0.767 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.709930e-01 0.767 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.714691e-01 0.766 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 1.718512e-01 0.765 0 0
HIV Transcription Initiation R-HSA-167161 1.718512e-01 0.765 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 1.718512e-01 0.765 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 1.726535e-01 0.763 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 1.738013e-01 0.760 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.738013e-01 0.760 0 0
Lagging Strand Synthesis R-HSA-69186 1.738013e-01 0.760 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.738013e-01 0.760 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.738013e-01 0.760 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.738013e-01 0.760 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.747084e-01 0.758 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.747084e-01 0.758 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.747084e-01 0.758 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.747084e-01 0.758 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.747084e-01 0.758 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.747084e-01 0.758 0 0
SOS-mediated signalling R-HSA-112412 1.747084e-01 0.758 0 0
Adherens junctions interactions R-HSA-418990 1.758120e-01 0.755 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.762843e-01 0.754 0 0
Muscle contraction R-HSA-397014 1.789258e-01 0.747 0 0
Cell-cell junction organization R-HSA-421270 1.793782e-01 0.746 0 0
Metalloprotease DUBs R-HSA-5689901 1.802623e-01 0.744 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.802623e-01 0.744 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.493357e-01 0.603 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.493357e-01 0.603 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.493357e-01 0.603 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.493357e-01 0.603 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.493357e-01 0.603 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.493357e-01 0.603 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.493357e-01 0.603 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.493357e-01 0.603 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.493357e-01 0.603 0 0
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) R-HSA-5619110 2.493357e-01 0.603 0 0
Defective SLC33A1 causes spastic paraplegia 42 (SPG42) R-HSA-5619061 2.493357e-01 0.603 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.493357e-01 0.603 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.493357e-01 0.603 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.493357e-01 0.603 0 0
NADE modulates death signalling R-HSA-205025 2.130315e-01 0.672 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.130315e-01 0.672 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.130315e-01 0.672 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.130315e-01 0.672 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.496264e-01 0.456 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.496264e-01 0.456 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.496264e-01 0.456 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.496264e-01 0.456 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.496264e-01 0.456 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.496264e-01 0.456 0 0
Defective GALE causes EDG R-HSA-5609977 3.496264e-01 0.456 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.496264e-01 0.456 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.496264e-01 0.456 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.496264e-01 0.456 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.496264e-01 0.456 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.496264e-01 0.456 0 0
Defective APRT disrupts adenine salvage R-HSA-9734195 3.496264e-01 0.456 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.496264e-01 0.456 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.496264e-01 0.456 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.496264e-01 0.456 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.496264e-01 0.456 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.496264e-01 0.456 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.496264e-01 0.456 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.496264e-01 0.456 0 0
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) R-HSA-5619048 3.496264e-01 0.456 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 3.496264e-01 0.456 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.656121e-01 0.576 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.656121e-01 0.576 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.656121e-01 0.576 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.656121e-01 0.576 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.656121e-01 0.576 0 0
G2 Phase R-HSA-68911 2.656121e-01 0.576 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 2.656121e-01 0.576 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.656121e-01 0.576 0 0
Defective F9 activation R-HSA-9673221 2.656121e-01 0.576 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 2.656121e-01 0.576 0 0
RSK activation R-HSA-444257 2.107509e-01 0.676 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.107509e-01 0.676 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.994098e-01 0.700 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.994098e-01 0.700 0 0
Repression of WNT target genes R-HSA-4641265 1.994098e-01 0.700 0 0
Pervasive developmental disorders R-HSA-9005895 1.994098e-01 0.700 0 0
Disorders of Nervous System Development R-HSA-9697154 1.994098e-01 0.700 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.994098e-01 0.700 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.994098e-01 0.700 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.482161e-01 0.605 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.482161e-01 0.605 0 0
Interleukin-21 signaling R-HSA-9020958 2.482161e-01 0.605 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.482161e-01 0.605 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.181937e-01 0.497 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 3.181937e-01 0.497 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 3.181937e-01 0.497 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.181937e-01 0.497 0 0
PKB-mediated events R-HSA-109703 3.181937e-01 0.497 0 0
PDE3B signalling R-HSA-165160 3.181937e-01 0.497 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.181937e-01 0.497 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.865096e-01 0.729 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.865096e-01 0.729 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.865096e-01 0.729 0 0
Formation of axial mesoderm R-HSA-9796292 2.291137e-01 0.640 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.112414e-01 0.675 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.112414e-01 0.675 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.949814e-01 0.710 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.598219e-01 0.585 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.369459e-01 0.625 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.369459e-01 0.625 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 3.253415e-01 0.488 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.995722e-01 0.700 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.912581e-01 0.536 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.399503e-01 0.620 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.018197e-01 0.695 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.018197e-01 0.695 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.867942e-01 0.729 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.403889e-01 0.619 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.635089e-01 0.579 0 0
Deadenylation of mRNA R-HSA-429947 2.635089e-01 0.579 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.635089e-01 0.579 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.905835e-01 0.537 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 2.022972e-01 0.694 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.617291e-01 0.582 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.617291e-01 0.582 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.617291e-01 0.582 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.589272e-01 0.587 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.552740e-01 0.449 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 2.348370e-01 0.629 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.517944e-01 0.599 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.460578e-01 0.461 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.088641e-01 0.680 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 1.913897e-01 0.718 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.478571e-01 0.606 0 0
mRNA 3'-end processing R-HSA-72187 2.478571e-01 0.606 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.994273e-01 0.524 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.692294e-01 0.570 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.636976e-01 0.579 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.412312e-01 0.467 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 3.516672e-01 0.454 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.682610e-01 0.571 0 0
Ub-specific processing proteases R-HSA-5689880 2.193011e-01 0.659 0 0
Viral mRNA Translation R-HSA-192823 2.864856e-01 0.543 0 0
Signaling by NOTCH2 R-HSA-1980145 2.393388e-01 0.621 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.048664e-01 0.689 0 0
Interleukin-15 signaling R-HSA-8983432 1.994098e-01 0.700 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.583353e-01 0.588 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.531366e-01 0.597 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.552740e-01 0.449 0 0
Myogenesis R-HSA-525793 3.121802e-01 0.506 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.865731e-01 0.543 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.112414e-01 0.675 0 0
Co-stimulation by CD28 R-HSA-389356 1.867405e-01 0.729 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.857151e-01 0.731 0 0
Protein folding R-HSA-391251 2.196536e-01 0.658 0 0
Activation of SMO R-HSA-5635838 3.231582e-01 0.491 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.617291e-01 0.582 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.121802e-01 0.506 0 0
Interleukin-2 family signaling R-HSA-451927 2.373767e-01 0.625 0 0
Interleukin-20 family signaling R-HSA-8854691 2.399503e-01 0.620 0 0
Integrin signaling R-HSA-354192 2.018197e-01 0.695 0 0
Platelet calcium homeostasis R-HSA-418360 2.403889e-01 0.619 0 0
Degradation of AXIN R-HSA-4641257 2.994273e-01 0.524 0 0
Apoptotic factor-mediated response R-HSA-111471 2.369459e-01 0.625 0 0
Degradation of DVL R-HSA-4641258 1.860048e-01 0.730 0 0
Adipogenesis R-HSA-9843745 2.221503e-01 0.653 0 0
Interleukin-9 signaling R-HSA-8985947 2.107509e-01 0.676 0 0
Frs2-mediated activation R-HSA-170968 2.291137e-01 0.640 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 2.876253e-01 0.541 0 0
Disorders of Developmental Biology R-HSA-9675151 3.552740e-01 0.449 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.930839e-01 0.533 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.417061e-01 0.466 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.130315e-01 0.672 0 0
Regulation of CDH11 function R-HSA-9762292 2.865731e-01 0.543 0 0
DNA strand elongation R-HSA-69190 1.840153e-01 0.735 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.876253e-01 0.541 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.876253e-01 0.541 0 0
Regulation of Apoptosis R-HSA-169911 2.589272e-01 0.587 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.164068e-01 0.665 0 0
GPVI-mediated activation cascade R-HSA-114604 2.789796e-01 0.554 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.989836e-01 0.524 0 0
Netrin-1 signaling R-HSA-373752 3.319132e-01 0.479 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.373767e-01 0.625 0 0
Diseases of Immune System R-HSA-5260271 2.373767e-01 0.625 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.284267e-01 0.484 0 0
Signalling to ERKs R-HSA-187687 2.589272e-01 0.587 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.202814e-01 0.657 0 0
PTEN Regulation R-HSA-6807070 2.467174e-01 0.608 0 0
Mismatch Repair R-HSA-5358508 2.369459e-01 0.625 0 0
Interleukin-6 family signaling R-HSA-6783589 2.635089e-01 0.579 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.995722e-01 0.700 0 0
FOXO-mediated transcription R-HSA-9614085 2.384557e-01 0.623 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.634508e-01 0.579 0 0
Activation of RAC1 R-HSA-428540 3.640963e-01 0.439 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.552740e-01 0.449 0 0
Orc1 removal from chromatin R-HSA-68949 3.603913e-01 0.443 0 0
Cellular response to starvation R-HSA-9711097 3.160128e-01 0.500 0 0
Interleukin-2 signaling R-HSA-9020558 3.253415e-01 0.488 0 0
Activation of BH3-only proteins R-HSA-114452 2.617291e-01 0.582 0 0
Interleukin-7 signaling R-HSA-1266695 2.876253e-01 0.541 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.123667e-01 0.505 0 0
Toll-like Receptor Cascades R-HSA-168898 2.072719e-01 0.683 0 0
Synthesis of DNA R-HSA-69239 2.682610e-01 0.571 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 2.865731e-01 0.543 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.781530e-01 0.556 0 0
Signaling by NOTCH R-HSA-157118 1.923969e-01 0.716 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.741211e-01 0.562 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.013347e-01 0.696 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.013347e-01 0.696 0 0
DNA Repair R-HSA-73894 2.028430e-01 0.693 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.130315e-01 0.672 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.656121e-01 0.576 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.482161e-01 0.605 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.181937e-01 0.497 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.181937e-01 0.497 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.112414e-01 0.675 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.112414e-01 0.675 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.598219e-01 0.585 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 3.640963e-01 0.439 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.512564e-01 0.454 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.355425e-01 0.628 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.185721e-01 0.497 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 2.741211e-01 0.562 0 0
Signaling by FGFR1 R-HSA-5654736 2.141203e-01 0.669 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.553508e-01 0.593 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.197027e-01 0.658 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.474604e-01 0.459 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.031210e-01 0.692 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.181937e-01 0.497 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.170688e-01 0.663 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.253415e-01 0.488 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.460578e-01 0.461 0 0
Interleukin-17 signaling R-HSA-448424 2.356379e-01 0.628 0 0
Signaling by Interleukins R-HSA-449147 2.986120e-01 0.525 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.237349e-01 0.490 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.656121e-01 0.576 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.865731e-01 0.543 0 0
ERK/MAPK targets R-HSA-198753 3.181741e-01 0.497 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.284267e-01 0.484 0 0
Integration of energy metabolism R-HSA-163685 3.571938e-01 0.447 0 0
Metabolism of RNA R-HSA-8953854 2.932129e-01 0.533 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.555338e-01 0.593 0 0
Regulation of pyruvate metabolism R-HSA-9861718 2.517944e-01 0.599 1 0
Signaling by NTRKs R-HSA-166520 2.813015e-01 0.551 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.072297e-01 0.513 0 0
Transmission across Chemical Synapses R-HSA-112315 2.622549e-01 0.581 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.493357e-01 0.603 0 0
SDK interactions R-HSA-373756 2.493357e-01 0.603 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.496264e-01 0.456 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.496264e-01 0.456 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.656121e-01 0.576 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.482161e-01 0.605 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.181937e-01 0.497 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.994273e-01 0.524 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.808165e-01 0.552 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.925023e-01 0.716 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.417061e-01 0.466 0 0
Growth hormone receptor signaling R-HSA-982772 2.399503e-01 0.620 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.960237e-01 0.708 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.441625e-01 0.463 0 0
Hemostasis R-HSA-109582 2.186748e-01 0.660 0 0
G0 and Early G1 R-HSA-1538133 1.840153e-01 0.735 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.552740e-01 0.449 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.373767e-01 0.625 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.018197e-01 0.695 0 0
Inositol phosphate metabolism R-HSA-1483249 3.293159e-01 0.482 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.636419e-01 0.439 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.930839e-01 0.533 0 0
Host Interactions of HIV factors R-HSA-162909 3.380086e-01 0.471 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.482161e-01 0.605 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.181937e-01 0.497 0 0
Glycogen storage diseases R-HSA-3229121 2.112414e-01 0.675 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.202814e-01 0.657 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.640963e-01 0.439 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.512564e-01 0.454 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.681748e-01 0.572 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.193011e-01 0.659 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.193011e-01 0.659 0 0
Interleukin-12 family signaling R-HSA-447115 2.235672e-01 0.651 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.516672e-01 0.454 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.516672e-01 0.454 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.853864e-01 0.545 0 0
Glucose metabolism R-HSA-70326 2.570915e-01 0.590 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.496264e-01 0.456 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 3.181937e-01 0.497 0 0
TRAIL signaling R-HSA-75158 3.181937e-01 0.497 0 0
The NLRP3 inflammasome R-HSA-844456 2.634508e-01 0.579 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.373767e-01 0.625 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.460578e-01 0.461 0 0
Plasma lipoprotein assembly R-HSA-8963898 2.635089e-01 0.579 0 0
Mitochondrial calcium ion transport R-HSA-8949215 3.460578e-01 0.461 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.121802e-01 0.506 0 0
Selenocysteine synthesis R-HSA-2408557 2.620502e-01 0.582 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.865096e-01 0.729 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.873884e-01 0.542 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.181741e-01 0.497 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.123667e-01 0.505 0 0
Signaling by ALK R-HSA-201556 3.412312e-01 0.467 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.496264e-01 0.456 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.656121e-01 0.576 0 0
Co-inhibition by BTLA R-HSA-9927353 2.656121e-01 0.576 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.403889e-01 0.619 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.624489e-01 0.441 0 0
HDL assembly R-HSA-8963896 2.598219e-01 0.585 0 0
Other semaphorin interactions R-HSA-416700 2.912581e-01 0.536 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.202010e-01 0.495 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.412312e-01 0.467 0 0
Regulation of BACH1 activity R-HSA-9708530 3.231582e-01 0.491 0 0
Extension of Telomeres R-HSA-180786 3.678303e-01 0.434 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.678303e-01 0.434 0 0
Chromatin organization R-HSA-4839726 3.682079e-01 0.434 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.698380e-01 0.432 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.698380e-01 0.432 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.698380e-01 0.432 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.715729e-01 0.430 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.740773e-01 0.427 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.742396e-01 0.427 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.742396e-01 0.427 0 0
Gap junction assembly R-HSA-190861 3.742396e-01 0.427 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 3.837866e-01 0.416 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.837866e-01 0.416 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.837866e-01 0.416 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.837866e-01 0.416 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.837866e-01 0.416 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.873118e-01 0.412 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.873118e-01 0.412 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.873765e-01 0.412 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.873765e-01 0.412 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 3.873765e-01 0.412 0 0
Specification of primordial germ cells R-HSA-9827857 3.873765e-01 0.412 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.963020e-01 0.402 0 0
PERK regulates gene expression R-HSA-381042 3.972927e-01 0.401 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 3.972927e-01 0.401 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.024695e-01 0.395 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.024695e-01 0.395 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.024695e-01 0.395 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.024695e-01 0.395 0 0
OAS antiviral response R-HSA-8983711 4.024695e-01 0.395 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.036562e-01 0.394 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.036562e-01 0.394 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.051782e-01 0.392 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.051782e-01 0.392 0 0
Influenza Infection R-HSA-168255 4.056691e-01 0.392 0 0
Transcription of the HIV genome R-HSA-167172 4.084813e-01 0.389 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.084813e-01 0.389 0 0
DAP12 signaling R-HSA-2424491 4.124757e-01 0.385 0 0
Activation of the pre-replicative complex R-HSA-68962 4.124757e-01 0.385 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.124757e-01 0.385 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.140665e-01 0.383 0 0
Cellular response to chemical stress R-HSA-9711123 4.155387e-01 0.381 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.164882e-01 0.380 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.170185e-01 0.380 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.178974e-01 0.379 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.192574e-01 0.378 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.192574e-01 0.378 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.198573e-01 0.377 0 0
PTK6 Expression R-HSA-8849473 4.198573e-01 0.377 0 0
Recycling of eIF2:GDP R-HSA-72731 4.198573e-01 0.377 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 4.198573e-01 0.377 0 0
Disinhibition of SNARE formation R-HSA-114516 4.198573e-01 0.377 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.198573e-01 0.377 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.198573e-01 0.377 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.198573e-01 0.377 0 0
Netrin mediated repulsion signals R-HSA-418886 4.198573e-01 0.377 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 4.198573e-01 0.377 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 4.198573e-01 0.377 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 4.198573e-01 0.377 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.198573e-01 0.377 0 0
Diseases of programmed cell death R-HSA-9645723 4.198658e-01 0.377 0 0
G1/S-Specific Transcription R-HSA-69205 4.203352e-01 0.376 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 4.241556e-01 0.372 0 0
Neuronal System R-HSA-112316 4.261841e-01 0.370 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.299415e-01 0.367 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.311468e-01 0.365 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.365231e-01 0.360 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 4.365231e-01 0.360 0 0
Defective UGT1A4 causes hyperbilirubinemia R-HSA-5579016 4.365231e-01 0.360 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.365231e-01 0.360 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.365231e-01 0.360 0 0
Defective visual phototransduction due to STRA6 loss of function R-HSA-9918449 4.365231e-01 0.360 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.365231e-01 0.360 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 4.365231e-01 0.360 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.365231e-01 0.360 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.365231e-01 0.360 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.365231e-01 0.360 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.365231e-01 0.360 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.365231e-01 0.360 0 0
C6 deamination of adenosine R-HSA-75102 4.365231e-01 0.360 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.365231e-01 0.360 0 0
DSCAM interactions R-HSA-376172 4.365231e-01 0.360 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.365231e-01 0.360 0 0
Signaling by WNT R-HSA-195721 4.370579e-01 0.359 0 0
Downstream signal transduction R-HSA-186763 4.375284e-01 0.359 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.375284e-01 0.359 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.401487e-01 0.356 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.401487e-01 0.356 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.401487e-01 0.356 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.401487e-01 0.356 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.401487e-01 0.356 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.401487e-01 0.356 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.401487e-01 0.356 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.401487e-01 0.356 0 0
Maturation of nucleoprotein R-HSA-9683610 4.401487e-01 0.356 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.427856e-01 0.354 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.507309e-01 0.346 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.507309e-01 0.346 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 4.507309e-01 0.346 0 0
Maturation of nucleoprotein R-HSA-9694631 4.507309e-01 0.346 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.507309e-01 0.346 0 0
PI3K Cascade R-HSA-109704 4.516328e-01 0.345 0 0
PI Metabolism R-HSA-1483255 4.542413e-01 0.343 0 0
IRS-mediated signalling R-HSA-112399 4.548009e-01 0.342 0 0
Insulin receptor signalling cascade R-HSA-74751 4.575213e-01 0.340 0 0
IGF1R signaling cascade R-HSA-2428924 4.575213e-01 0.340 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.575218e-01 0.340 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.660865e-01 0.332 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.670832e-01 0.331 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.677641e-01 0.330 0 0
MET receptor recycling R-HSA-8875656 4.677641e-01 0.330 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.677641e-01 0.330 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.677641e-01 0.330 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 4.677641e-01 0.330 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.677641e-01 0.330 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.677641e-01 0.330 0 0
Sodium/Proton exchangers R-HSA-425986 4.677641e-01 0.330 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.690521e-01 0.329 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.735748e-01 0.325 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.753642e-01 0.323 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.768746e-01 0.322 0 0
Removal of the Flap Intermediate R-HSA-69166 4.768746e-01 0.322 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.768746e-01 0.322 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.768746e-01 0.322 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.768746e-01 0.322 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.768746e-01 0.322 0 0
Signal regulatory protein family interactions R-HSA-391160 4.768746e-01 0.322 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.769327e-01 0.322 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 4.788560e-01 0.320 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.816334e-01 0.317 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.816334e-01 0.317 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.816334e-01 0.317 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.816334e-01 0.317 0 0
Formation of definitive endoderm R-HSA-9823730 4.816334e-01 0.317 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.816334e-01 0.317 0 0
TCR signaling R-HSA-202403 4.835623e-01 0.316 0 0
Chromatin modifying enzymes R-HSA-3247509 4.839503e-01 0.315 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.847106e-01 0.315 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.847106e-01 0.315 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.869346e-01 0.313 0 0
Plasma lipoprotein clearance R-HSA-8964043 4.886555e-01 0.311 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.900495e-01 0.310 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.900495e-01 0.310 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.900495e-01 0.310 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.900495e-01 0.310 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.912165e-01 0.309 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.931552e-01 0.307 0 0
Ca2+ pathway R-HSA-4086398 4.938718e-01 0.306 0 0
Signaling by FGFR2 R-HSA-5654738 4.945714e-01 0.306 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 4.957897e-01 0.305 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.981465e-01 0.303 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.999255e-01 0.301 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.106934e-01 0.292 0 0
Pyruvate metabolism R-HSA-70268 5.107380e-01 0.292 1 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.108114e-01 0.292 0 0
Glycogen metabolism R-HSA-8982491 5.109348e-01 0.292 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.114053e-01 0.291 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.114053e-01 0.291 0 0
Signaling by BMP R-HSA-201451 5.114053e-01 0.291 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.114053e-01 0.291 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.114053e-01 0.291 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.114053e-01 0.291 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.114053e-01 0.291 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 5.114053e-01 0.291 0 0
Invadopodia formation R-HSA-8941237 5.118138e-01 0.291 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 5.118138e-01 0.291 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 5.118138e-01 0.291 0 0
MET activates PTPN11 R-HSA-8865999 5.118138e-01 0.291 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 5.118138e-01 0.291 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.118138e-01 0.291 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 5.118138e-01 0.291 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 5.118234e-01 0.291 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.118234e-01 0.291 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.118234e-01 0.291 0 0
Ion channel transport R-HSA-983712 5.119289e-01 0.291 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.124375e-01 0.290 0 0
Erythropoietin activates RAS R-HSA-9027284 5.124375e-01 0.290 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.124375e-01 0.290 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.124375e-01 0.290 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.124375e-01 0.290 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.124375e-01 0.290 0 0
Protein methylation R-HSA-8876725 5.124375e-01 0.290 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.124375e-01 0.290 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.124375e-01 0.290 0 0
ARMS-mediated activation R-HSA-170984 5.132301e-01 0.290 0 0
Lipophagy R-HSA-9613354 5.132301e-01 0.290 0 0
WNT mediated activation of DVL R-HSA-201688 5.132301e-01 0.290 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 5.132301e-01 0.290 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.132301e-01 0.290 0 0
Calcineurin activates NFAT R-HSA-2025928 5.132301e-01 0.290 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.132301e-01 0.290 0 0
Unwinding of DNA R-HSA-176974 5.132301e-01 0.290 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.132301e-01 0.290 0 0
MAPK1 (ERK2) activation R-HSA-112411 5.132301e-01 0.290 0 0
Interleukin-1 processing R-HSA-448706 5.132301e-01 0.290 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.225373e-01 0.282 0 0
Platelet homeostasis R-HSA-418346 5.248640e-01 0.280 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.248640e-01 0.280 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.256624e-01 0.279 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.300894e-01 0.276 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.328670e-01 0.273 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.348724e-01 0.272 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.367656e-01 0.270 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.367656e-01 0.270 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.367656e-01 0.270 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.375157e-01 0.270 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.375157e-01 0.270 0 0
Inflammasomes R-HSA-622312 5.375157e-01 0.270 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.411814e-01 0.267 0 0
Neutrophil degranulation R-HSA-6798695 5.432203e-01 0.265 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.466729e-01 0.262 0 0
Atorvastatin ADME R-HSA-9754706 5.466729e-01 0.262 0 0
Killing mechanisms R-HSA-9664420 5.466729e-01 0.262 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.466729e-01 0.262 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.466729e-01 0.262 0 0
tRNA processing in the nucleus R-HSA-6784531 5.470048e-01 0.262 0 0
Intraflagellar transport R-HSA-5620924 5.514417e-01 0.259 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.524676e-01 0.258 0 0
Co-inhibition by PD-1 R-HSA-389948 5.531024e-01 0.257 0 0
Translation of Structural Proteins R-HSA-9683701 5.544001e-01 0.256 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 5.560523e-01 0.255 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.560523e-01 0.255 0 0
2-LTR circle formation R-HSA-164843 5.560523e-01 0.255 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.560523e-01 0.255 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.560523e-01 0.255 0 0
Formation of apoptosome R-HSA-111458 5.560523e-01 0.255 0 0
PI3K/AKT activation R-HSA-198203 5.560523e-01 0.255 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.560523e-01 0.255 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.560523e-01 0.255 0 0
Interleukin-27 signaling R-HSA-9020956 5.560523e-01 0.255 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.560523e-01 0.255 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 5.560523e-01 0.255 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.560523e-01 0.255 0 0
Signaling by Erythropoietin R-HSA-9006335 5.629633e-01 0.250 0 0
Chromosome Maintenance R-HSA-73886 5.632703e-01 0.249 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.660701e-01 0.247 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.674018e-01 0.246 0 0
mTORC1-mediated signalling R-HSA-166208 5.696081e-01 0.244 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.696081e-01 0.244 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.754872e-01 0.240 0 0
HCN channels R-HSA-1296061 5.770481e-01 0.239 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.770481e-01 0.239 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 5.770481e-01 0.239 0 0
Defective FMO3 causes TMAU R-HSA-5579019 5.770481e-01 0.239 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.770481e-01 0.239 0 0
Signaling by LRP5 mutants R-HSA-5339717 5.770481e-01 0.239 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.770481e-01 0.239 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.770481e-01 0.239 0 0
Regulation of gap junction activity R-HSA-191650 5.770481e-01 0.239 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.770481e-01 0.239 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.770481e-01 0.239 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.770481e-01 0.239 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.770481e-01 0.239 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.770481e-01 0.239 0 0
GABA synthesis R-HSA-888568 5.770481e-01 0.239 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.770481e-01 0.239 0 0
Dopamine receptors R-HSA-390651 5.770481e-01 0.239 0 0
Transmission across Electrical Synapses R-HSA-112307 5.770481e-01 0.239 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.770481e-01 0.239 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.789832e-01 0.237 0 0
Generic Transcription Pathway R-HSA-212436 5.811770e-01 0.236 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 5.876815e-01 0.231 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.876815e-01 0.231 0 0
RNA Polymerase II Transcription R-HSA-73857 5.877780e-01 0.231 0 0
Gene expression (Transcription) R-HSA-74160 5.931466e-01 0.227 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.961256e-01 0.225 0 0
Dissolution of Fibrin Clot R-HSA-75205 5.961256e-01 0.225 0 0
Formation of the posterior neural plate R-HSA-9832991 5.961256e-01 0.225 0 0
Chylomicron assembly R-HSA-8963888 5.961256e-01 0.225 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.961256e-01 0.225 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.961256e-01 0.225 0 0
Suppression of apoptosis R-HSA-9635465 5.961256e-01 0.225 0 0
LGI-ADAM interactions R-HSA-5682910 5.961256e-01 0.225 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 5.970238e-01 0.224 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 5.970238e-01 0.224 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.970238e-01 0.224 0 0
Cellular response to hypoxia R-HSA-1234174 5.994186e-01 0.222 0 0
Signaling by MET R-HSA-6806834 6.074759e-01 0.216 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.107013e-01 0.214 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.107013e-01 0.214 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.107013e-01 0.214 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.149352e-01 0.211 0 0
DAP12 interactions R-HSA-2172127 6.161627e-01 0.210 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.161627e-01 0.210 0 0
Regulation of beta-cell development R-HSA-186712 6.216585e-01 0.206 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.227273e-01 0.206 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.233667e-01 0.205 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.280371e-01 0.202 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.334198e-01 0.198 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.334198e-01 0.198 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 6.334198e-01 0.198 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.334198e-01 0.198 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 6.334198e-01 0.198 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.334198e-01 0.198 0 0
ERKs are inactivated R-HSA-202670 6.334198e-01 0.198 0 0
Integration of provirus R-HSA-162592 6.334198e-01 0.198 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.335687e-01 0.198 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 6.335687e-01 0.198 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.335687e-01 0.198 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.335687e-01 0.198 0 0
NTRK2 activates RAC1 R-HSA-9032759 6.335687e-01 0.198 0 0
Activation of AKT2 R-HSA-165158 6.335687e-01 0.198 0 0
PTK6 Down-Regulation R-HSA-8849472 6.335687e-01 0.198 0 0
Suppression of autophagy R-HSA-9636569 6.335687e-01 0.198 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.335687e-01 0.198 0 0
Reelin signalling pathway R-HSA-8866376 6.335687e-01 0.198 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.356840e-01 0.197 0 0
Nucleosome assembly R-HSA-774815 6.356840e-01 0.197 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.356840e-01 0.197 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 6.403495e-01 0.194 0 0
GAB1 signalosome R-HSA-180292 6.403495e-01 0.194 0 0
Tie2 Signaling R-HSA-210993 6.403495e-01 0.194 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.432954e-01 0.192 0 0
RAS processing R-HSA-9648002 6.450710e-01 0.190 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.460322e-01 0.190 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.485913e-01 0.188 0 0
Tight junction interactions R-HSA-420029 6.485913e-01 0.188 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.485913e-01 0.188 0 0
DNA Replication R-HSA-69306 6.487797e-01 0.188 0 0
Aquaporin-mediated transport R-HSA-445717 6.555720e-01 0.183 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.569581e-01 0.182 0 0
Base Excision Repair R-HSA-73884 6.611616e-01 0.180 0 0
rRNA processing R-HSA-72312 6.626130e-01 0.179 0 0
Generation of second messenger molecules R-HSA-202433 6.651150e-01 0.177 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 6.679621e-01 0.175 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 6.679621e-01 0.175 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 6.679621e-01 0.175 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.679621e-01 0.175 0 0
Interleukin-35 Signalling R-HSA-8984722 6.679621e-01 0.175 0 0
Signaling by LTK R-HSA-9842663 6.679621e-01 0.175 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.683716e-01 0.175 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.683716e-01 0.175 0 0
Other interleukin signaling R-HSA-449836 6.683716e-01 0.175 0 0
Signaling by PDGF R-HSA-186797 6.718562e-01 0.173 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.726671e-01 0.172 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.726671e-01 0.172 0 0
Translation of Structural Proteins R-HSA-9694635 6.727647e-01 0.172 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 6.729625e-01 0.172 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.747490e-01 0.171 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.783074e-01 0.169 0 0
COPII-mediated vesicle transport R-HSA-204005 6.797150e-01 0.168 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.825391e-01 0.166 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.825391e-01 0.166 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.825391e-01 0.166 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.825391e-01 0.166 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 6.825391e-01 0.166 0 0
Synthesis of PS R-HSA-1483101 6.825391e-01 0.166 0 0
Ceramide signalling R-HSA-193681 6.825391e-01 0.166 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.825391e-01 0.166 0 0
Intestinal hexose absorption R-HSA-8981373 6.825391e-01 0.166 0 0
Relaxin receptors R-HSA-444821 6.825391e-01 0.166 0 0
Ligand-receptor interactions R-HSA-5632681 6.825391e-01 0.166 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.876724e-01 0.163 0 0
IRE1alpha activates chaperones R-HSA-381070 6.880212e-01 0.162 0 0
NGF-stimulated transcription R-HSA-9031628 6.906815e-01 0.161 0 0
GPER1 signaling R-HSA-9634597 6.906815e-01 0.161 0 0
Mitochondrial biogenesis R-HSA-1592230 6.919100e-01 0.160 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.942278e-01 0.158 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.945596e-01 0.158 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.947608e-01 0.158 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.947608e-01 0.158 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.947608e-01 0.158 0 0
Signaling by NODAL R-HSA-1181150 6.947608e-01 0.158 0 0
Signal transduction by L1 R-HSA-445144 6.947608e-01 0.158 0 0
Signaling by FGFR R-HSA-190236 6.950717e-01 0.158 0 0
Cristae formation R-HSA-8949613 6.955767e-01 0.158 0 0
Ion homeostasis R-HSA-5578775 6.969001e-01 0.157 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.987497e-01 0.156 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.987497e-01 0.156 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.987497e-01 0.156 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.998219e-01 0.155 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 6.998219e-01 0.155 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 6.998219e-01 0.155 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.998219e-01 0.155 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 6.998219e-01 0.155 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 6.998219e-01 0.155 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.998219e-01 0.155 0 0
Signaling by Insulin receptor R-HSA-74752 7.009701e-01 0.154 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.009701e-01 0.154 0 0
HATs acetylate histones R-HSA-3214847 7.074158e-01 0.150 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.074979e-01 0.150 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.077689e-01 0.150 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.173147e-01 0.144 0 0
Telomere Extension By Telomerase R-HSA-171319 7.173147e-01 0.144 0 0
Pyroptosis R-HSA-5620971 7.173147e-01 0.144 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.182756e-01 0.144 0 0
Signalling to RAS R-HSA-167044 7.195291e-01 0.143 0 0
Basigin interactions R-HSA-210991 7.195291e-01 0.143 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.214561e-01 0.142 0 0
Chylomicron clearance R-HSA-8964026 7.249674e-01 0.140 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.249674e-01 0.140 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.249674e-01 0.140 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 7.249674e-01 0.140 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 7.249674e-01 0.140 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.249674e-01 0.140 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.249674e-01 0.140 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.249674e-01 0.140 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.249674e-01 0.140 0 0
Intracellular metabolism of fatty acids regulates insulin secretion R-HSA-434313 7.249674e-01 0.140 0 0
HDL clearance R-HSA-8964011 7.249674e-01 0.140 0 0
VLDL assembly R-HSA-8866423 7.249674e-01 0.140 0 0
Lipid particle organization R-HSA-8964572 7.249674e-01 0.140 0 0
Leukotriene receptors R-HSA-391906 7.249674e-01 0.140 0 0
CREB3 factors activate genes R-HSA-8874211 7.249674e-01 0.140 0 0
cGMP effects R-HSA-418457 7.290991e-01 0.137 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.290991e-01 0.137 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 7.290991e-01 0.137 0 0
Prolactin receptor signaling R-HSA-1170546 7.290991e-01 0.137 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.290991e-01 0.137 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.368827e-01 0.133 0 0
RNA Polymerase III Transcription R-HSA-74158 7.368827e-01 0.133 0 0
Triglyceride catabolism R-HSA-163560 7.368827e-01 0.133 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.427044e-01 0.129 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.427044e-01 0.129 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.427044e-01 0.129 0 0
ER-Phagosome pathway R-HSA-1236974 7.451132e-01 0.128 0 0
Protein ubiquitination R-HSA-8852135 7.495518e-01 0.125 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.495518e-01 0.125 0 0
Selenoamino acid metabolism R-HSA-2408522 7.555762e-01 0.122 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.559149e-01 0.122 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 7.559149e-01 0.122 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.559149e-01 0.122 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.559149e-01 0.122 0 0
Signaling by Activin R-HSA-1502540 7.559149e-01 0.122 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.559149e-01 0.122 0 0
Biotin transport and metabolism R-HSA-196780 7.559149e-01 0.122 0 0
Formation of the anterior neural plate R-HSA-9823739 7.559149e-01 0.122 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.617274e-01 0.118 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.617274e-01 0.118 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.617274e-01 0.118 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.617274e-01 0.118 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 7.617274e-01 0.118 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.617274e-01 0.118 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.617274e-01 0.118 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.617274e-01 0.118 0 0
LDL remodeling R-HSA-8964041 7.617274e-01 0.118 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 7.617274e-01 0.118 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.617274e-01 0.118 0 0
CHL1 interactions R-HSA-447041 7.617274e-01 0.118 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.643273e-01 0.117 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.643273e-01 0.117 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.643273e-01 0.117 0 0
Meiotic synapsis R-HSA-1221632 7.696844e-01 0.114 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 7.696844e-01 0.114 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.697342e-01 0.114 0 0
Somitogenesis R-HSA-9824272 7.697342e-01 0.114 0 0
Developmental Biology R-HSA-1266738 7.701078e-01 0.113 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.706443e-01 0.113 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.712653e-01 0.113 0 0
Telomere Maintenance R-HSA-157579 7.715669e-01 0.113 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 7.722737e-01 0.112 0 0
RSV-host interactions R-HSA-9833110 7.748646e-01 0.111 0 0
Meiosis R-HSA-1500620 7.767533e-01 0.110 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.804041e-01 0.108 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 7.804041e-01 0.108 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.804041e-01 0.108 0 0
Differentiation of T cells R-HSA-9945266 7.804041e-01 0.108 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.804041e-01 0.108 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 7.804041e-01 0.108 0 0
Regulation of insulin secretion R-HSA-422356 7.821230e-01 0.107 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.835549e-01 0.106 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.837062e-01 0.106 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.837062e-01 0.106 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.844482e-01 0.105 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.844482e-01 0.105 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.844482e-01 0.105 0 0
Carnitine shuttle R-HSA-200425 7.844482e-01 0.105 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.845385e-01 0.105 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.845385e-01 0.105 0 0
Adaptive Immune System R-HSA-1280218 7.852713e-01 0.105 0 0
ABC transporter disorders R-HSA-5619084 7.860849e-01 0.105 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.872565e-01 0.104 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.921929e-01 0.101 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.935759e-01 0.100 0 0
phospho-PLA2 pathway R-HSA-111995 7.935759e-01 0.100 0 0
Activation of RAS in B cells R-HSA-1169092 7.935759e-01 0.100 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.935759e-01 0.100 0 0
Adrenoceptors R-HSA-390696 7.935759e-01 0.100 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.935759e-01 0.100 0 0
Co-stimulation by ICOS R-HSA-9927354 7.935759e-01 0.100 0 0
Nucleotide salvage defects R-HSA-9734207 7.935759e-01 0.100 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.935759e-01 0.100 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.935759e-01 0.100 0 0
Intestinal absorption R-HSA-8963676 7.935759e-01 0.100 0 0
Interleukin-23 signaling R-HSA-9020933 7.935759e-01 0.100 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.964857e-01 0.099 0 0
Parasite infection R-HSA-9664407 7.997794e-01 0.097 0 0
Leishmania phagocytosis R-HSA-9664417 7.997794e-01 0.097 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.997794e-01 0.097 0 0
ABC-family proteins mediated transport R-HSA-382556 8.021947e-01 0.096 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.022780e-01 0.096 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.022780e-01 0.096 0 0
HIV Transcription Elongation R-HSA-167169 8.022780e-01 0.096 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 8.027096e-01 0.095 0 0
Phase 2 - plateau phase R-HSA-5576893 8.027096e-01 0.095 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.027096e-01 0.095 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 8.027096e-01 0.095 0 0
Galactose catabolism R-HSA-70370 8.027096e-01 0.095 0 0
Synthesis of PG R-HSA-1483148 8.027096e-01 0.095 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.027096e-01 0.095 0 0
PPARA activates gene expression R-HSA-1989781 8.056595e-01 0.094 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.078531e-01 0.093 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.078531e-01 0.093 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.082022e-01 0.092 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.088718e-01 0.092 0 0
Recycling of bile acids and salts R-HSA-159418 8.088718e-01 0.092 0 0
Gluconeogenesis R-HSA-70263 8.119571e-01 0.090 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.133953e-01 0.090 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.204219e-01 0.086 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.204219e-01 0.086 0 0
HDMs demethylate histones R-HSA-3214842 8.204219e-01 0.086 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.207158e-01 0.086 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.211691e-01 0.086 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.211691e-01 0.086 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.211691e-01 0.086 0 0
Enzymatic degradation of Dopamine by monoamine oxidase R-HSA-379398 8.211691e-01 0.086 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 8.211691e-01 0.086 0 0
mRNA Editing R-HSA-75072 8.211691e-01 0.086 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.211691e-01 0.086 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.211691e-01 0.086 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.211691e-01 0.086 0 0
Cellular response to mitochondrial stress R-HSA-9840373 8.211691e-01 0.086 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.211691e-01 0.086 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.229774e-01 0.085 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.229774e-01 0.085 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.229774e-01 0.085 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.229774e-01 0.085 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.229774e-01 0.085 0 0
Heme degradation R-HSA-189483 8.239406e-01 0.084 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.239406e-01 0.084 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.279213e-01 0.082 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.290318e-01 0.081 0 0
Signaling by FGFR in disease R-HSA-1226099 8.291428e-01 0.081 0 0
Intra-Golgi traffic R-HSA-6811438 8.297903e-01 0.081 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 8.328088e-01 0.079 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.364057e-01 0.078 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.364057e-01 0.078 0 0
Downstream TCR signaling R-HSA-202424 8.377305e-01 0.077 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.380121e-01 0.077 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.380121e-01 0.077 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.381098e-01 0.077 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.408322e-01 0.075 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.413536e-01 0.075 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.413536e-01 0.075 0 0
Nephron development R-HSA-9831926 8.413536e-01 0.075 0 0
Peroxisomal protein import R-HSA-9033241 8.436263e-01 0.074 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.436263e-01 0.074 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.450752e-01 0.073 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 8.450752e-01 0.073 0 0
Enzymatic degradation of dopamine by COMT R-HSA-379397 8.450752e-01 0.073 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.450752e-01 0.073 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.450752e-01 0.073 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.450752e-01 0.073 0 0
Arachidonate production from DAG R-HSA-426048 8.450752e-01 0.073 0 0
Sperm Motility And Taxes R-HSA-1300642 8.450752e-01 0.073 0 0
Parasitic Infection Pathways R-HSA-9824443 8.474592e-01 0.072 0 0
Leishmania infection R-HSA-9658195 8.474592e-01 0.072 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.485624e-01 0.071 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.511464e-01 0.070 0 0
RAB geranylgeranylation R-HSA-8873719 8.538753e-01 0.069 0 0
tRNA Aminoacylation R-HSA-379724 8.538753e-01 0.069 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.544708e-01 0.068 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.579818e-01 0.067 0 0
HDL remodeling R-HSA-8964058 8.579818e-01 0.067 0 0
Specification of the neural plate border R-HSA-9834899 8.579818e-01 0.067 0 0
Diseases of hemostasis R-HSA-9671793 8.579818e-01 0.067 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.579818e-01 0.067 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.584995e-01 0.066 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.633320e-01 0.064 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.633320e-01 0.064 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.635726e-01 0.064 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.638090e-01 0.064 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.647148e-01 0.063 0 0
Insulin receptor recycling R-HSA-77387 8.647148e-01 0.063 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.647148e-01 0.063 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.647148e-01 0.063 0 0
Proteasome assembly R-HSA-9907900 8.651310e-01 0.063 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.657867e-01 0.063 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.657867e-01 0.063 0 0
vRNA Synthesis R-HSA-192814 8.657867e-01 0.063 0 0
Synthesis of PI R-HSA-1483226 8.657867e-01 0.063 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.657867e-01 0.063 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.657867e-01 0.063 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.657867e-01 0.063 0 0
Prostanoid ligand receptors R-HSA-391908 8.657867e-01 0.063 0 0
RNA Polymerase I Transcription R-HSA-73864 8.661932e-01 0.062 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.678968e-01 0.062 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 8.685249e-01 0.061 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.730007e-01 0.059 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.730007e-01 0.059 0 0
Protein hydroxylation R-HSA-9629569 8.730007e-01 0.059 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.730007e-01 0.059 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 8.730007e-01 0.059 0 0
Melanin biosynthesis R-HSA-5662702 8.730007e-01 0.059 0 0
Voltage gated Potassium channels R-HSA-1296072 8.746684e-01 0.058 0 0
Metabolism of folate and pterines R-HSA-196757 8.746684e-01 0.058 0 0
mRNA Capping R-HSA-72086 8.771817e-01 0.057 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.771817e-01 0.057 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.771817e-01 0.057 0 0
Mitochondrial protein degradation R-HSA-9837999 8.780151e-01 0.056 1 1
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.837304e-01 0.054 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.837304e-01 0.054 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.837304e-01 0.054 0 0
DS-GAG biosynthesis R-HSA-2022923 8.837304e-01 0.054 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.837304e-01 0.054 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.837304e-01 0.054 0 0
FMO oxidises nucleophiles R-HSA-217271 8.837304e-01 0.054 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.837304e-01 0.054 0 0
Sodium/Calcium exchangers R-HSA-425561 8.837304e-01 0.054 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.865434e-01 0.052 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.865434e-01 0.052 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.865434e-01 0.052 0 0
G alpha (z) signalling events R-HSA-418597 8.868033e-01 0.052 0 0
HDACs deacetylate histones R-HSA-3214815 8.868033e-01 0.052 0 0
Reproduction R-HSA-1474165 8.874137e-01 0.052 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.886173e-01 0.051 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.886173e-01 0.051 0 0
Neurotransmitter clearance R-HSA-112311 8.886173e-01 0.051 0 0
Amyloid fiber formation R-HSA-977225 8.894925e-01 0.051 0 0
Pentose phosphate pathway R-HSA-71336 8.949181e-01 0.048 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.949181e-01 0.048 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.951046e-01 0.048 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.987361e-01 0.046 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 8.987361e-01 0.046 0 0
Serine metabolism R-HSA-977347 8.987361e-01 0.046 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.992760e-01 0.046 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.992760e-01 0.046 0 0
MET activates RAS signaling R-HSA-8851805 8.992760e-01 0.046 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.992760e-01 0.046 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.992760e-01 0.046 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.992760e-01 0.046 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.992760e-01 0.046 0 0
Metal ion SLC transporters R-HSA-425410 9.024570e-01 0.045 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.030776e-01 0.044 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.039206e-01 0.044 0 0
Iron uptake and transport R-HSA-917937 9.066709e-01 0.043 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.086666e-01 0.042 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.096976e-01 0.041 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.096976e-01 0.041 0 0
FGFR2 alternative splicing R-HSA-6803529 9.096976e-01 0.041 0 0
LDL clearance R-HSA-8964038 9.096976e-01 0.041 0 0
Chylomicron remodeling R-HSA-8963901 9.127439e-01 0.040 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.127439e-01 0.040 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.127439e-01 0.040 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.127439e-01 0.040 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.127439e-01 0.040 0 0
Triglyceride metabolism R-HSA-8979227 9.169508e-01 0.038 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.169508e-01 0.038 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 9.174110e-01 0.037 0 0
G-protein beta:gamma signalling R-HSA-397795 9.174110e-01 0.037 0 0
Cardiogenesis R-HSA-9733709 9.174110e-01 0.037 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.195390e-01 0.036 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.195390e-01 0.036 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.195390e-01 0.036 0 0
Biosynthesis of maresins R-HSA-9018682 9.195390e-01 0.036 0 0
Interferon gamma signaling R-HSA-877300 9.204793e-01 0.036 0 0
Translation R-HSA-72766 9.211895e-01 0.036 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.232947e-01 0.035 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 9.232947e-01 0.035 0 0
Meiotic recombination R-HSA-912446 9.242154e-01 0.034 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.244117e-01 0.034 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.244117e-01 0.034 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.244117e-01 0.034 0 0
Hydrolysis of LPC R-HSA-1483115 9.244117e-01 0.034 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.244117e-01 0.034 0 0
Malate-aspartate shuttle R-HSA-9856872 9.244117e-01 0.034 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.244117e-01 0.034 0 0
Zinc transporters R-HSA-435354 9.244117e-01 0.034 0 0
P2Y receptors R-HSA-417957 9.244117e-01 0.034 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.253849e-01 0.034 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.253849e-01 0.034 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.253849e-01 0.034 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.262084e-01 0.033 1 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.283640e-01 0.032 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.283640e-01 0.032 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.283640e-01 0.032 0 0
Formation of the cornified envelope R-HSA-6809371 9.287489e-01 0.032 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.291260e-01 0.032 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.304464e-01 0.031 0 0
Cardiac conduction R-HSA-5576891 9.314943e-01 0.031 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.326467e-01 0.030 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.345198e-01 0.029 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.345198e-01 0.029 0 0
Transport and metabolism of PAPS R-HSA-174362 9.345198e-01 0.029 0 0
p38MAPK events R-HSA-171007 9.345198e-01 0.029 0 0
Protein repair R-HSA-5676934 9.345198e-01 0.029 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.345198e-01 0.029 0 0
Mitochondrial protein import R-HSA-1268020 9.347173e-01 0.029 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.362682e-01 0.029 0 0
Laminin interactions R-HSA-3000157 9.362682e-01 0.029 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.392519e-01 0.027 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.392519e-01 0.027 0 0
RMTs methylate histone arginines R-HSA-3214858 9.394179e-01 0.027 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.432767e-01 0.025 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.432767e-01 0.025 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.432767e-01 0.025 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 9.432767e-01 0.025 0 0
Fructose catabolism R-HSA-70350 9.432767e-01 0.025 0 0
Attachment and Entry R-HSA-9678110 9.432767e-01 0.025 0 0
Ion transport by P-type ATPases R-HSA-936837 9.446045e-01 0.025 0 0
ESR-mediated signaling R-HSA-8939211 9.448926e-01 0.025 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.452527e-01 0.024 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 9.496609e-01 0.022 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 9.496609e-01 0.022 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.496609e-01 0.022 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.496609e-01 0.022 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.499114e-01 0.022 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.499114e-01 0.022 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.506985e-01 0.022 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.508630e-01 0.022 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.508630e-01 0.022 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.508630e-01 0.022 0 0
Heme assimilation R-HSA-9927020 9.508630e-01 0.022 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.508630e-01 0.022 0 0
Passive transport by Aquaporins R-HSA-432047 9.508630e-01 0.022 0 0
Gene Silencing by RNA R-HSA-211000 9.528983e-01 0.021 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.549156e-01 0.020 0 0
Protein localization R-HSA-9609507 9.549839e-01 0.020 0 0
HIV elongation arrest and recovery R-HSA-167287 9.553050e-01 0.020 0 0
Pausing and recovery of HIV elongation R-HSA-167290 9.553050e-01 0.020 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.553050e-01 0.020 0 0
Prednisone ADME R-HSA-9757110 9.553050e-01 0.020 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.556353e-01 0.020 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.574351e-01 0.019 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 9.574351e-01 0.019 0 0
Catecholamine biosynthesis R-HSA-209905 9.574351e-01 0.019 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.574351e-01 0.019 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.579071e-01 0.019 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.587109e-01 0.018 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.601061e-01 0.018 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.603402e-01 0.018 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.603402e-01 0.018 1 1
Regulation of endogenous retroelements R-HSA-9842860 9.613325e-01 0.017 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.615595e-01 0.017 0 0
Integrin cell surface interactions R-HSA-216083 9.623200e-01 0.017 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.631284e-01 0.016 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.631284e-01 0.016 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.631284e-01 0.016 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.631284e-01 0.016 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.631284e-01 0.016 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.641510e-01 0.016 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.641510e-01 0.016 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.648285e-01 0.016 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.652453e-01 0.015 0 0
SARS-CoV Infections R-HSA-9679506 9.676117e-01 0.014 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.678070e-01 0.014 0 0
Maturation of spike protein R-HSA-9694548 9.678070e-01 0.014 0 0
Pyrimidine biosynthesis R-HSA-500753 9.680606e-01 0.014 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.680606e-01 0.014 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.680606e-01 0.014 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.680606e-01 0.014 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.680606e-01 0.014 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.688260e-01 0.014 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.688260e-01 0.014 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.711087e-01 0.013 0 0
Neurotransmitter release cycle R-HSA-112310 9.719678e-01 0.012 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.721762e-01 0.012 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 9.723332e-01 0.012 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.723332e-01 0.012 0 0
Creatine metabolism R-HSA-71288 9.723332e-01 0.012 0 0
Pregnenolone biosynthesis R-HSA-196108 9.723332e-01 0.012 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.723836e-01 0.012 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.730846e-01 0.012 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.735075e-01 0.012 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.737672e-01 0.012 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.740878e-01 0.011 0 0
Depyrimidination R-HSA-73928 9.740878e-01 0.011 0 0
Nucleotide biosynthesis R-HSA-8956320 9.748315e-01 0.011 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.749607e-01 0.011 0 0
HCMV Early Events R-HSA-9609690 9.751315e-01 0.011 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.755476e-01 0.011 0 0
Nuclear RNA decay R-HSA-9930044 9.755476e-01 0.011 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.760345e-01 0.011 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.760345e-01 0.011 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.767736e-01 0.010 0 0
Glucuronidation R-HSA-156588 9.772473e-01 0.010 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.783595e-01 0.010 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.790422e-01 0.009 0 0
Amine ligand-binding receptors R-HSA-375280 9.791931e-01 0.009 0 0
CS-GAG biosynthesis R-HSA-2022870 9.792408e-01 0.009 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.792408e-01 0.009 0 0
Attachment and Entry R-HSA-9694614 9.792408e-01 0.009 0 0
Extracellular matrix organization R-HSA-1474244 9.796830e-01 0.009 0 0
Gastrulation R-HSA-9758941 9.801563e-01 0.009 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.808570e-01 0.008 0 0
eNOS activation R-HSA-203615 9.808570e-01 0.008 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.820183e-01 0.008 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.820183e-01 0.008 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.820183e-01 0.008 0 0
Reactions specific to the complex N-glycan synthesis pathway R-HSA-975578 9.820183e-01 0.008 0 0
Fructose metabolism R-HSA-5652084 9.820183e-01 0.008 0 0
Ethanol oxidation R-HSA-71384 9.820183e-01 0.008 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.820183e-01 0.008 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.820183e-01 0.008 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.830737e-01 0.007 0 0
Synthesis of PA R-HSA-1483166 9.832496e-01 0.007 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.833299e-01 0.007 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.844243e-01 0.007 0 0
Formation of the ureteric bud R-HSA-9830674 9.844243e-01 0.007 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.844243e-01 0.007 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.844243e-01 0.007 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.848922e-01 0.007 0 0
Glycosphingolipid transport R-HSA-9845576 9.850401e-01 0.007 0 0
CYP2E1 reactions R-HSA-211999 9.865085e-01 0.006 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.865085e-01 0.006 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.865085e-01 0.006 0 0
Complex III assembly R-HSA-9865881 9.865085e-01 0.006 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.865085e-01 0.006 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.867834e-01 0.006 0 0
Collagen chain trimerization R-HSA-8948216 9.867834e-01 0.006 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.868248e-01 0.006 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.868248e-01 0.006 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.877297e-01 0.005 1 1
Metabolism of cofactors R-HSA-8978934 9.880560e-01 0.005 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.883139e-01 0.005 0 0
Hyaluronan degradation R-HSA-2160916 9.883139e-01 0.005 0 0
Fertilization R-HSA-1187000 9.883139e-01 0.005 0 0
Formation of the nephric duct R-HSA-9830364 9.883139e-01 0.005 0 0
Retinoid cycle disease events R-HSA-2453864 9.883139e-01 0.005 0 0
Diseases of the neuronal system R-HSA-9675143 9.883139e-01 0.005 0 0
Diseases associated with visual transduction R-HSA-2474795 9.883139e-01 0.005 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.883139e-01 0.005 0 0
MET promotes cell motility R-HSA-8875878 9.883282e-01 0.005 0 0
Elastic fibre formation R-HSA-1566948 9.883282e-01 0.005 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.888480e-01 0.005 0 0
Collagen degradation R-HSA-1442490 9.889505e-01 0.005 0 0
Azathioprine ADME R-HSA-9748787 9.893657e-01 0.005 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.896964e-01 0.004 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.898778e-01 0.004 0 0
Urea cycle R-HSA-70635 9.898778e-01 0.004 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.898778e-01 0.004 0 0
Sphingolipid catabolism R-HSA-9845614 9.898778e-01 0.004 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.898778e-01 0.004 0 0
Potential therapeutics for SARS R-HSA-9679191 9.900427e-01 0.004 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 9.900547e-01 0.004 0 0
Aspirin ADME R-HSA-9749641 9.901990e-01 0.004 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.901990e-01 0.004 0 0
Immune System R-HSA-168256 9.902297e-01 0.004 0 0
The phototransduction cascade R-HSA-2514856 9.905075e-01 0.004 0 0
Tryptophan catabolism R-HSA-71240 9.909075e-01 0.004 0 0
Packaging Of Telomere Ends R-HSA-171306 9.912325e-01 0.004 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.912325e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.912325e-01 0.004 0 0
Insulin processing R-HSA-264876 9.912325e-01 0.004 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.912477e-01 0.004 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.915306e-01 0.004 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.916210e-01 0.004 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.919732e-01 0.004 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.919790e-01 0.003 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.919790e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.920795e-01 0.003 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.924467e-01 0.003 0 0
HCMV Infection R-HSA-9609646 9.926833e-01 0.003 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.932666e-01 0.003 0 0
DNA methylation R-HSA-5334118 9.934224e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.935041e-01 0.003 0 0
Activation of GABAB receptors R-HSA-991365 9.937645e-01 0.003 0 0
GABA B receptor activation R-HSA-977444 9.937645e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.937645e-01 0.003 0 0
Kidney development R-HSA-9830369 9.941669e-01 0.003 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.943029e-01 0.002 0 0
SLC transporter disorders R-HSA-5619102 9.943614e-01 0.002 0 0
Developmental Cell Lineages R-HSA-9734767 9.943719e-01 0.002 0 0
Innate Immune System R-HSA-168249 9.944944e-01 0.002 0 0
Neddylation R-HSA-8951664 9.949976e-01 0.002 0 0
Cargo concentration in the ER R-HSA-5694530 9.950655e-01 0.002 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.957261e-01 0.002 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.957261e-01 0.002 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.957360e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.962235e-01 0.002 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.962235e-01 0.002 0 0
Metabolism of porphyrins R-HSA-189445 9.962235e-01 0.002 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.966490e-01 0.001 0 0
Metabolism of polyamines R-HSA-351202 9.966490e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.966519e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.966519e-01 0.001 0 0
CS/DS degradation R-HSA-2024101 9.967939e-01 0.001 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.967939e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.967946e-01 0.001 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.969790e-01 0.001 0 0
Viral Infection Pathways R-HSA-9824446 9.970814e-01 0.001 0 0
HCMV Late Events R-HSA-9610379 9.971289e-01 0.001 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.972232e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.972232e-01 0.001 0 0
RA biosynthesis pathway R-HSA-5365859 9.972232e-01 0.001 0 0
Signal amplification R-HSA-392518 9.972232e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.972857e-01 0.001 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.974301e-01 0.001 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.974301e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.975950e-01 0.001 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.977495e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.977495e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.978528e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.979613e-01 0.001 0 0
tRNA processing R-HSA-72306 9.979763e-01 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.980472e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.981312e-01 0.001 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.981960e-01 0.001 0 0
Cleavage of the damaged purine R-HSA-110331 9.981960e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.981960e-01 0.001 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.981960e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.982615e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.983418e-01 0.001 0 0
Depurination R-HSA-73927 9.984376e-01 0.001 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.984376e-01 0.001 0 0
Purine salvage R-HSA-74217 9.984376e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.984376e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.985669e-01 0.001 0 0
Phospholipid metabolism R-HSA-1483257 9.986994e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.987041e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.988195e-01 0.001 0 0
N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975576 9.988281e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.989631e-01 0.000 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.989851e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.990786e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.990878e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.991211e-01 0.000 0 0
Defective pyroptosis R-HSA-9710421 9.993408e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.993408e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.993840e-01 0.000 0 0
Methylation R-HSA-156581 9.994291e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.994595e-01 0.000 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.995056e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.995056e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.995380e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.996292e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.996292e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.996352e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.997527e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997542e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997542e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.997915e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.998455e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998551e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.998731e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.998828e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999040e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.999121e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999123e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999459e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999500e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.999506e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999553e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999617e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999617e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999629e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999629e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999650e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999679e-01 0.000 0 0
Disease R-HSA-1643685 9.999753e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999792e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999796e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999801e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999820e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999829e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.999865e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999878e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999883e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999890e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999899e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999924e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999956e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.999957e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999957e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999962e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999963e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999964e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999966e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999974e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999978e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999979e-01 0.000 1 0
Peroxisomal lipid metabolism R-HSA-390918 9.999982e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999983e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999983e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999987e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999987e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999988e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999988e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999990e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999991e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999995e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999997e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999998e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999998e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999998e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999999e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 1 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
mRNA Splicing - Major Pathway R-HSA-72163 1.190499e-07 6.924 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.837288e-08 7.106 0 0
mRNA Splicing R-HSA-72172 2.101123e-07 6.678 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.000355e-07 6.046 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.134062e-06 5.945 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.775891e-06 5.751 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.998481e-06 5.699 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.311061e-06 5.636 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.421880e-06 5.616 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.864921e-06 5.543 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.149404e-06 5.089 0 0
Apoptotic execution phase R-HSA-75153 1.295551e-05 4.888 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.863955e-05 4.730 0 0
Gap junction trafficking and regulation R-HSA-157858 1.751804e-05 4.757 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 3.566814e-05 4.448 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 3.827585e-05 4.417 0 0
Gap junction assembly R-HSA-190861 4.512812e-05 4.346 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.957364e-05 4.158 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.046358e-05 4.152 0 0
Aggrephagy R-HSA-9646399 8.545601e-05 4.068 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 9.573587e-05 4.019 0 0
Developmental Biology R-HSA-1266738 1.001557e-04 3.999 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.037083e-04 3.984 0 0
Gap junction trafficking R-HSA-190828 1.365286e-04 3.865 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.684531e-04 3.774 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.767663e-04 3.753 0 0
Recycling pathway of L1 R-HSA-437239 1.767663e-04 3.753 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.915434e-04 3.718 0 0
MHC class II antigen presentation R-HSA-2132295 3.160622e-04 3.500 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 4.215787e-04 3.375 0 0
Kinesins R-HSA-983189 4.639824e-04 3.333 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.285081e-04 3.277 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.990350e-04 3.302 0 0
G2/M Transition R-HSA-69275 7.022437e-04 3.154 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.473777e-04 3.126 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.056225e-04 3.043 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.385691e-04 3.028 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.011241e-03 2.995 0 0
Signaling by Hippo R-HSA-2028269 1.187091e-03 2.926 0 0
Ephrin signaling R-HSA-3928664 1.347330e-03 2.871 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.281569e-03 2.892 0 0
Cell Cycle R-HSA-1640170 1.253702e-03 2.902 0 0
Nervous system development R-HSA-9675108 1.514719e-03 2.820 0 0
L1CAM interactions R-HSA-373760 1.423113e-03 2.847 0 0
PKR-mediated signaling R-HSA-9833482 1.453870e-03 2.837 0 0
Mitotic Anaphase R-HSA-68882 1.707415e-03 2.768 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.752663e-03 2.756 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.810865e-03 2.742 0 0
Intraflagellar transport R-HSA-5620924 1.932434e-03 2.714 0 0
Formation of the cornified envelope R-HSA-6809371 1.917983e-03 2.717 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.208534e-03 2.656 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.208534e-03 2.656 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.121734e-03 2.673 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.338942e-03 2.631 0 0
Selective autophagy R-HSA-9663891 2.214737e-03 2.655 0 0
Post NMDA receptor activation events R-HSA-438064 2.118362e-03 2.674 0 0
Axon guidance R-HSA-422475 2.444221e-03 2.612 0 0
Metabolism of RNA R-HSA-8953854 2.536562e-03 2.596 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.592392e-03 2.586 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.592392e-03 2.586 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.592392e-03 2.586 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.362107e-03 2.473 0 0
Cilium Assembly R-HSA-5617833 3.516153e-03 2.454 0 0
Mitotic Prometaphase R-HSA-68877 3.797803e-03 2.420 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.858908e-03 2.414 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.490051e-03 2.348 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.490051e-03 2.348 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.096300e-03 2.388 0 0
M Phase R-HSA-68886 4.515636e-03 2.345 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.490051e-03 2.348 0 0
Signaling by PTK6 R-HSA-8848021 4.490051e-03 2.348 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.227209e-03 2.374 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.521595e-03 2.345 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.746366e-03 2.324 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.813170e-03 2.318 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.187307e-03 2.285 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.424942e-03 2.266 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.578933e-03 2.253 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.613722e-03 2.251 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.641897e-03 2.178 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.224948e-03 2.206 0 0
Regulation of CDH11 function R-HSA-9762292 6.641897e-03 2.178 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.693603e-03 2.245 0 0
Signal Transduction R-HSA-162582 6.759022e-03 2.170 1 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.763840e-03 2.170 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.791941e-03 2.168 0 0
Cell junction organization R-HSA-446728 6.867129e-03 2.163 0 0
Apoptosis R-HSA-109581 6.905158e-03 2.161 0 0
Adherens junctions interactions R-HSA-418990 7.012861e-03 2.154 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 7.087837e-03 2.149 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.656746e-03 2.116 0 0
Centrosome maturation R-HSA-380287 7.704920e-03 2.113 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 8.321542e-03 2.080 0 0
Cell Cycle, Mitotic R-HSA-69278 8.720672e-03 2.059 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 8.765095e-03 2.057 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.035812e-02 1.985 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.235615e-02 1.908 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.091749e-02 1.962 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.258535e-02 1.900 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.282344e-02 1.892 0 0
Cell-Cell communication R-HSA-1500931 1.343108e-02 1.872 0 0
Cell-cell junction organization R-HSA-421270 1.357526e-02 1.867 0 0
DCC mediated attractive signaling R-HSA-418885 1.368478e-02 1.864 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.393760e-02 1.856 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.417106e-02 1.849 0 0
EPH-Ephrin signaling R-HSA-2682334 1.537882e-02 1.813 0 0
Protein folding R-HSA-391251 1.537882e-02 1.813 0 0
HCMV Early Events R-HSA-9609690 1.547087e-02 1.810 0 0
Macroautophagy R-HSA-1632852 1.629286e-02 1.788 0 0
Degradation of CDH1 R-HSA-9766229 1.633787e-02 1.787 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.833681e-02 1.737 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.833681e-02 1.737 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.833681e-02 1.737 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.833681e-02 1.737 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.833681e-02 1.737 0 0
Keratinization R-HSA-6805567 1.924286e-02 1.716 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.957831e-02 1.708 0 0
Potential therapeutics for SARS R-HSA-9679191 2.060202e-02 1.686 0 0
Hedgehog 'off' state R-HSA-5610787 2.025313e-02 1.694 0 0
Programmed Cell Death R-HSA-5357801 1.887631e-02 1.724 0 0
Membrane Trafficking R-HSA-199991 2.211208e-02 1.655 0 0
Formation of definitive endoderm R-HSA-9823730 2.285629e-02 1.641 0 0
Regulation of CDH1 Function R-HSA-9764561 2.297748e-02 1.639 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.297748e-02 1.639 0 0
Autophagy R-HSA-9612973 2.351452e-02 1.629 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.634312e-02 1.579 0 0
Separation of Sister Chromatids R-HSA-2467813 2.779442e-02 1.556 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.816214e-02 1.550 0 0
FGFR2 alternative splicing R-HSA-6803529 2.816214e-02 1.550 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.816214e-02 1.550 0 0
Deadenylation of mRNA R-HSA-429947 3.194611e-02 1.496 0 0
Interferon Signaling R-HSA-913531 3.506875e-02 1.455 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.633961e-02 1.440 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.797141e-02 1.421 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.797141e-02 1.421 0 0
HIV elongation arrest and recovery R-HSA-167287 4.006900e-02 1.397 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.006900e-02 1.397 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.887928e-02 1.311 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.220953e-02 1.375 0 0
Developmental Cell Lineages R-HSA-9734767 4.883847e-02 1.311 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.220953e-02 1.375 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.922843e-02 1.406 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.965755e-02 1.402 0 0
HCMV Infection R-HSA-9609646 4.050049e-02 1.393 0 0
Viral Infection Pathways R-HSA-9824446 3.731164e-02 1.428 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.439205e-02 1.353 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.661561e-02 1.331 0 0
Cellular responses to stimuli R-HSA-8953897 4.219263e-02 1.375 0 0
Signaling by FGFR2 R-HSA-5654738 4.901676e-02 1.310 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.118216e-02 1.291 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.352332e-02 1.271 0 0
Regulation of gap junction activity R-HSA-191650 5.401442e-02 1.267 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.401442e-02 1.267 0 0
Signaling by Hedgehog R-HSA-5358351 5.676959e-02 1.246 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.831699e-02 1.234 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.831699e-02 1.234 0 0
Cellular responses to stress R-HSA-2262752 5.850178e-02 1.233 0 0
FLT3 signaling in disease R-HSA-9682385 6.076775e-02 1.216 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.273069e-02 1.203 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.325332e-02 1.199 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.546355e-02 1.184 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.832554e-02 1.165 0 0
Adaptive Immune System R-HSA-1280218 7.006075e-02 1.155 0 0
Gastrulation R-HSA-9758941 7.045174e-02 1.152 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.091056e-02 1.149 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.091056e-02 1.149 0 0
HIV Transcription Elongation R-HSA-167169 7.091056e-02 1.149 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.091056e-02 1.149 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.091056e-02 1.149 0 0
Diseases of Immune System R-HSA-5260271 7.091056e-02 1.149 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 7.136719e-02 1.147 0 0
Phosphorylation of Emi1 R-HSA-176417 7.136719e-02 1.147 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 7.136719e-02 1.147 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.166213e-02 1.145 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.352710e-02 1.134 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.992463e-02 1.097 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.071083e-01 0.970 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.100668e-01 0.958 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.100668e-01 0.958 0 0
PTK6 Expression R-HSA-8849473 8.840374e-02 1.054 0 0
MAP2K and MAPK activation R-HSA-5674135 7.617438e-02 1.118 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.617438e-02 1.118 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.984494e-02 1.047 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.984494e-02 1.047 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.984494e-02 1.047 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.051298e-01 0.978 0 0
Unwinding of DNA R-HSA-176974 1.051298e-01 0.978 0 0
Signaling by RAS mutants R-HSA-6802949 8.984494e-02 1.047 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 9.550193e-02 1.020 0 0
Vesicle-mediated transport R-HSA-5653656 8.407174e-02 1.075 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 8.822614e-02 1.054 0 0
Cellular Senescence R-HSA-2559583 1.142460e-01 0.942 0 0
Signaling by FGFR R-HSA-190236 8.125809e-02 1.090 0 0
RSV-host interactions R-HSA-9833110 9.361217e-02 1.029 0 0
SARS-CoV Infections R-HSA-9679506 8.794044e-02 1.056 0 0
Netrin-1 signaling R-HSA-373752 8.429289e-02 1.074 0 0
Transmission across Chemical Synapses R-HSA-112315 1.002230e-01 0.999 0 0
HDACs deacetylate histones R-HSA-3214815 1.160477e-01 0.935 0 0
Signaling by NOTCH3 R-HSA-9012852 1.160477e-01 0.935 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.183345e-01 0.927 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.184310e-01 0.927 0 0
Signaling by EGFR R-HSA-177929 1.190687e-01 0.924 0 0
Transport of RCbl within the body R-HSA-9758890 1.215510e-01 0.915 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.282469e-01 0.892 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.282469e-01 0.892 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.376728e-01 0.861 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.456232e-01 0.837 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.690401e-01 0.772 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 1.690401e-01 0.772 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 1.690401e-01 0.772 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.690401e-01 0.772 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.842960e-01 0.734 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 1.842960e-01 0.734 0 0
Regulation of signaling by CBL R-HSA-912631 1.992737e-01 0.701 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.992737e-01 0.701 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 2.139782e-01 0.670 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 2.212295e-01 0.655 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.355334e-01 0.628 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.355334e-01 0.628 0 0
Termination of O-glycan biosynthesis R-HSA-977068 2.355334e-01 0.628 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.599111e-01 0.796 0 0
Transcription of the HIV genome R-HSA-167172 1.566805e-01 0.805 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.470679e-01 0.832 0 0
Formation of axial mesoderm R-HSA-9796292 1.456232e-01 0.837 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.066598e-01 0.685 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.762395e-01 0.754 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.842960e-01 0.734 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.613062e-01 0.792 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.856157e-01 0.731 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.565015e-01 0.591 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.664088e-01 0.779 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.879321e-01 0.726 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 1.535008e-01 0.814 0 0
UCH proteinases R-HSA-5689603 1.828437e-01 0.738 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.095876e-01 0.679 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.129604e-01 0.672 0 0
NF-kB is activated and signals survival R-HSA-209560 1.296490e-01 0.887 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 1.918193e-01 0.717 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 1.992737e-01 0.701 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.344556e-01 0.871 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.918193e-01 0.717 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.664088e-01 0.779 0 0
Negative regulation of MET activity R-HSA-6807004 2.066598e-01 0.685 0 0
HIV Life Cycle R-HSA-162587 2.210868e-01 0.655 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.696750e-01 0.770 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.961571e-01 0.707 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.469197e-01 0.607 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.729520e-01 0.762 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.613062e-01 0.792 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 1.376728e-01 0.861 0 0
Protein lipoylation R-HSA-9857492 1.613062e-01 0.792 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.613062e-01 0.792 0 0
Negative regulation of FLT3 R-HSA-9706369 1.690401e-01 0.772 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.425872e-01 0.615 0 0
TGFBR3 expression R-HSA-9839394 2.495764e-01 0.603 0 0
DNA Double Strand Break Response R-HSA-5693606 1.534628e-01 0.814 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.565015e-01 0.591 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.313426e-01 0.882 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.894841e-01 0.722 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.114870e-01 0.675 0 0
p75NTR signals via NF-kB R-HSA-193639 1.613062e-01 0.792 0 0
Myogenesis R-HSA-525793 2.565015e-01 0.591 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 2.066598e-01 0.685 0 0
Chromosome Maintenance R-HSA-73886 1.306309e-01 0.884 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.139782e-01 0.670 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.139782e-01 0.670 0 0
Regulation of KIT signaling R-HSA-1433559 1.535008e-01 0.814 0 0
mTORC1-mediated signalling R-HSA-166208 2.284144e-01 0.641 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 2.495764e-01 0.603 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 2.565015e-01 0.591 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.139782e-01 0.670 0 0
HDMs demethylate histones R-HSA-3214842 2.495764e-01 0.603 0 0
Mitotic Prophase R-HSA-68875 1.285673e-01 0.891 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.767031e-01 0.753 0 0
Deubiquitination R-HSA-5688426 2.511341e-01 0.600 0 0
Signaling by FGFR in disease R-HSA-1226099 1.762395e-01 0.754 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.613062e-01 0.792 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.495764e-01 0.603 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.495764e-01 0.603 0 0
Post-translational protein modification R-HSA-597592 1.450477e-01 0.838 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.565015e-01 0.591 0 0
GAB1 signalosome R-HSA-180292 1.918193e-01 0.717 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.918193e-01 0.717 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 2.565015e-01 0.591 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.696262e-01 0.771 0 0
Hemostasis R-HSA-109582 2.131640e-01 0.671 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.664088e-01 0.779 0 0
Infectious disease R-HSA-5663205 1.645477e-01 0.784 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 2.495764e-01 0.603 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.131397e-01 0.671 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.984618e-01 0.702 0 0
Integrin cell surface interactions R-HSA-216083 1.894841e-01 0.722 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.284144e-01 0.641 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.347273e-01 0.629 0 0
Signaling by VEGF R-HSA-194138 1.411218e-01 0.850 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 2.495764e-01 0.603 0 0
Chromatin organization R-HSA-4839726 2.391557e-01 0.621 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.856157e-01 0.731 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.842960e-01 0.734 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.842960e-01 0.734 0 0
Interleukin-6 signaling R-HSA-1059683 1.456232e-01 0.837 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.708554e-01 0.767 0 0
Interleukin-6 family signaling R-HSA-6783589 2.425872e-01 0.615 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 1.718852e-01 0.765 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.633631e-01 0.579 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.633631e-01 0.579 0 0
Telomere Maintenance R-HSA-157579 2.639876e-01 0.578 0 0
Post-translational protein phosphorylation R-HSA-8957275 2.674031e-01 0.573 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.701618e-01 0.568 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.701618e-01 0.568 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 2.701618e-01 0.568 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.701618e-01 0.568 0 0
DNA Repair R-HSA-73894 2.764912e-01 0.558 0 0
mRNA Capping R-HSA-72086 2.768981e-01 0.558 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 2.768981e-01 0.558 0 0
Neutrophil degranulation R-HSA-6798695 2.824619e-01 0.549 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.835727e-01 0.547 0 0
Activation of the pre-replicative complex R-HSA-68962 2.835727e-01 0.547 0 0
DAP12 signaling R-HSA-2424491 2.835727e-01 0.547 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.835727e-01 0.547 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.878849e-01 0.541 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.878849e-01 0.541 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.901861e-01 0.537 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.901861e-01 0.537 0 0
EGFR downregulation R-HSA-182971 2.901861e-01 0.537 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.912942e-01 0.536 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.912942e-01 0.536 0 0
Nucleotide Excision Repair R-HSA-5696398 2.947015e-01 0.531 0 0
DNA strand elongation R-HSA-69190 2.967389e-01 0.528 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.981065e-01 0.526 0 0
Neuronal System R-HSA-112316 3.000122e-01 0.523 0 0
Synthesis of DNA R-HSA-69239 3.015092e-01 0.521 0 0
Gene Silencing by RNA R-HSA-211000 3.015092e-01 0.521 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.032315e-01 0.518 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.032315e-01 0.518 0 0
Integrin signaling R-HSA-354192 3.032315e-01 0.518 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.032315e-01 0.518 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.032315e-01 0.518 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.032315e-01 0.518 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.032315e-01 0.518 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.032315e-01 0.518 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.083061e-01 0.511 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.096647e-01 0.509 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.096647e-01 0.509 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.096647e-01 0.509 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.096647e-01 0.509 0 0
Heme degradation R-HSA-189483 3.096647e-01 0.509 0 0
TCR signaling R-HSA-202403 3.116999e-01 0.506 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.146969e-01 0.502 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.160388e-01 0.500 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 3.160388e-01 0.500 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 3.160388e-01 0.500 0 0
Nuclear import of Rev protein R-HSA-180746 3.160388e-01 0.500 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 3.160388e-01 0.500 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 3.223545e-01 0.492 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.223545e-01 0.492 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.252390e-01 0.488 0 0
RUNX2 regulates bone development R-HSA-8941326 3.286122e-01 0.483 0 0
GPVI-mediated activation cascade R-HSA-114604 3.286122e-01 0.483 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.286122e-01 0.483 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 3.286122e-01 0.483 0 0
FGFR2 mutant receptor activation R-HSA-1839126 3.286122e-01 0.483 0 0
RET signaling R-HSA-8853659 3.286122e-01 0.483 0 0
RNA Polymerase III Transcription R-HSA-74158 3.286122e-01 0.483 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.286122e-01 0.483 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.286136e-01 0.483 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.348125e-01 0.475 0 0
Interferon alpha/beta signaling R-HSA-909733 3.353493e-01 0.475 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.409560e-01 0.467 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.470430e-01 0.460 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.470430e-01 0.460 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.470430e-01 0.460 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.470430e-01 0.460 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.470430e-01 0.460 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.487605e-01 0.457 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.487605e-01 0.457 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.530743e-01 0.452 0 0
Generation of second messenger molecules R-HSA-202433 3.530743e-01 0.452 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.530743e-01 0.452 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.530743e-01 0.452 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.530743e-01 0.452 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.530743e-01 0.452 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.554330e-01 0.449 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.587604e-01 0.445 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.587604e-01 0.445 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.590502e-01 0.445 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.590502e-01 0.445 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.590502e-01 0.445 0 0
FLT3 Signaling R-HSA-9607240 3.590502e-01 0.445 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.590502e-01 0.445 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.649712e-01 0.438 0 0
HIV Transcription Initiation R-HSA-167161 3.649712e-01 0.438 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.649712e-01 0.438 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.649712e-01 0.438 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.708380e-01 0.431 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.708380e-01 0.431 0 0
MTOR signalling R-HSA-165159 3.708380e-01 0.431 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.766509e-01 0.424 0 0
Signaling by FGFR4 R-HSA-5654743 3.766509e-01 0.424 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.766509e-01 0.424 0 0
Signaling by SCF-KIT R-HSA-1433557 3.766509e-01 0.424 0 0
G2/M Checkpoints R-HSA-69481 3.785895e-01 0.422 0 0
Platelet degranulation R-HSA-114608 3.785895e-01 0.422 0 0
Gene expression (Transcription) R-HSA-74160 3.823523e-01 0.418 0 0
DAP12 interactions R-HSA-2172127 3.824104e-01 0.417 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 3.824104e-01 0.417 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.824104e-01 0.417 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 3.824104e-01 0.417 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.881171e-01 0.411 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.881171e-01 0.411 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.881171e-01 0.411 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.881171e-01 0.411 0 0
Nucleosome assembly R-HSA-774815 3.881171e-01 0.411 0 0
Signaling by FGFR3 R-HSA-5654741 3.881171e-01 0.411 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.937714e-01 0.405 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.937714e-01 0.405 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.937714e-01 0.405 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.937714e-01 0.405 1 0
Signaling by TGFBR3 R-HSA-9839373 3.937714e-01 0.405 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 3.993738e-01 0.399 0 0
HIV Infection R-HSA-162906 4.006894e-01 0.397 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.013978e-01 0.396 0 0
NGF-stimulated transcription R-HSA-9031628 4.049247e-01 0.393 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.158743e-01 0.381 0 0
Chromatin modifying enzymes R-HSA-3247509 4.179709e-01 0.379 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.212737e-01 0.375 0 0
PTEN Regulation R-HSA-6807070 4.238105e-01 0.373 0 0
ESR-mediated signaling R-HSA-8939211 4.253295e-01 0.371 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.266236e-01 0.370 0 0
Orc1 removal from chromatin R-HSA-68949 4.266236e-01 0.370 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.266236e-01 0.370 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.319244e-01 0.365 0 0
Smooth Muscle Contraction R-HSA-445355 4.319244e-01 0.365 0 0
Translation initiation complex formation R-HSA-72649 4.371765e-01 0.359 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.371765e-01 0.359 0 0
Paracetamol ADME R-HSA-9753281 4.423803e-01 0.354 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.458187e-01 0.351 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.475364e-01 0.349 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.475364e-01 0.349 0 0
Signaling by FGFR1 R-HSA-5654736 4.475364e-01 0.349 0 0
Dectin-2 family R-HSA-5621480 4.526451e-01 0.344 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.526451e-01 0.344 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.550641e-01 0.342 0 0
S Phase R-HSA-69242 4.550641e-01 0.342 0 0
Dual incision in TC-NER R-HSA-6782135 4.577069e-01 0.339 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.577069e-01 0.339 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.577069e-01 0.339 0 0
Metabolism of non-coding RNA R-HSA-194441 4.627221e-01 0.335 0 0
snRNP Assembly R-HSA-191859 4.627221e-01 0.335 0 0
Amino acid transport across the plasma membrane R-HSA-352230 4.627221e-01 0.335 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.642521e-01 0.333 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 4.672948e-01 0.330 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 4.676913e-01 0.330 0 0
DNA Replication R-HSA-69306 4.703272e-01 0.328 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.733495e-01 0.325 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.763614e-01 0.322 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.774932e-01 0.321 0 0
tRNA processing in the nucleus R-HSA-6784531 4.774932e-01 0.321 0 0
Heme signaling R-HSA-9707616 4.774932e-01 0.321 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.774932e-01 0.321 0 0
Complex I biogenesis R-HSA-6799198 4.823267e-01 0.317 0 0
Regulation of TP53 Activity R-HSA-5633007 4.912644e-01 0.309 0 0
Signaling by TGFB family members R-HSA-9006936 4.912644e-01 0.309 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.965623e-01 0.304 0 0
SLC-mediated transport of amino acids R-HSA-9958863 5.012205e-01 0.300 0 0
O-linked glycosylation of mucins R-HSA-913709 5.058359e-01 0.296 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.058359e-01 0.296 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.129678e-01 0.290 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.149399e-01 0.288 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.149399e-01 0.288 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.157315e-01 0.288 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.194292e-01 0.284 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.194292e-01 0.284 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 5.194292e-01 0.284 0 0
Metabolism of porphyrins R-HSA-189445 5.194292e-01 0.284 0 0
Immune System R-HSA-168256 5.202087e-01 0.284 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.238773e-01 0.281 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.238773e-01 0.281 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 5.238773e-01 0.281 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.259312e-01 0.279 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.282844e-01 0.277 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.310031e-01 0.275 0 0
Ub-specific processing proteases R-HSA-5689880 5.315539e-01 0.274 0 0
G2/M DNA damage checkpoint R-HSA-69473 5.326510e-01 0.274 0 0
Signaling by ERBB4 R-HSA-1236394 5.326510e-01 0.274 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.369775e-01 0.270 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.369775e-01 0.270 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.371314e-01 0.270 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.412642e-01 0.267 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 5.455114e-01 0.263 0 0
Influenza Infection R-HSA-168255 5.481500e-01 0.261 0 0
RNA Polymerase I Transcription R-HSA-73864 5.497196e-01 0.260 0 0
Sensory processing of sound R-HSA-9659379 5.538891e-01 0.257 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.552620e-01 0.256 0 0
Signaling by MET R-HSA-6806834 5.580203e-01 0.253 0 0
Processing of DNA double-strand break ends R-HSA-5693607 5.621134e-01 0.250 0 0
Amyloid fiber formation R-HSA-977225 5.621134e-01 0.250 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 5.661689e-01 0.247 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.661689e-01 0.247 0 0
Disease R-HSA-1643685 5.683735e-01 0.245 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.701871e-01 0.244 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.741683e-01 0.241 0 0
Metabolism of proteins R-HSA-392499 5.791166e-01 0.237 1 0
Toll-like Receptor Cascades R-HSA-168898 5.801017e-01 0.236 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.820211e-01 0.235 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.826890e-01 0.235 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.858934e-01 0.232 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.858934e-01 0.232 0 0
Pyruvate metabolism R-HSA-70268 5.897301e-01 0.229 1 0
ER-Phagosome pathway R-HSA-1236974 5.972979e-01 0.224 0 0
Downstream TCR signaling R-HSA-202424 6.010296e-01 0.221 0 0
Neurotransmitter release cycle R-HSA-112310 6.010296e-01 0.221 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.103797e-01 0.214 0 0
Mitochondrial protein degradation R-HSA-9837999 6.191791e-01 0.208 1 1
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 6.227094e-01 0.206 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.227094e-01 0.206 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.296727e-01 0.201 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.331063e-01 0.199 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.331063e-01 0.199 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.365083e-01 0.196 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.365083e-01 0.196 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.365083e-01 0.196 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.398790e-01 0.194 0 0
Glycolysis R-HSA-70171 6.432186e-01 0.192 0 0
ABC-family proteins mediated transport R-HSA-382556 6.432186e-01 0.192 0 0
Interleukin-1 signaling R-HSA-9020702 6.465274e-01 0.189 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.498058e-01 0.187 0 0
PI Metabolism R-HSA-1483255 6.498058e-01 0.187 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 6.530540e-01 0.185 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 6.594608e-01 0.181 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.610617e-01 0.180 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.626200e-01 0.179 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.719240e-01 0.173 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.719240e-01 0.173 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.719240e-01 0.173 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.719240e-01 0.173 0 0
Stimuli-sensing channels R-HSA-2672351 6.719240e-01 0.173 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.749683e-01 0.171 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.779846e-01 0.169 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.779846e-01 0.169 0 0
FCERI mediated MAPK activation R-HSA-2871796 6.839340e-01 0.165 0 0
Inositol phosphate metabolism R-HSA-1483249 6.839340e-01 0.165 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.868676e-01 0.163 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.897742e-01 0.161 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.905625e-01 0.161 1 0
Signaling by NOTCH R-HSA-157118 6.952921e-01 0.158 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.955072e-01 0.158 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 6.983341e-01 0.156 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.011350e-01 0.154 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.011350e-01 0.154 0 0
Rab regulation of trafficking R-HSA-9007101 7.039100e-01 0.152 0 0
Glucose metabolism R-HSA-70326 7.039100e-01 0.152 0 0
Generic Transcription Pathway R-HSA-212436 7.057958e-01 0.151 0 0
Homology Directed Repair R-HSA-5693538 7.066594e-01 0.151 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.093834e-01 0.149 0 0
Innate Immune System R-HSA-168249 7.126073e-01 0.147 0 0
Cellular response to heat stress R-HSA-3371556 7.147564e-01 0.146 0 0
Host Interactions of HIV factors R-HSA-162909 7.226314e-01 0.141 0 0
G1/S Transition R-HSA-69206 7.277610e-01 0.138 0 0
Cell Cycle Checkpoints R-HSA-69620 7.299085e-01 0.137 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 7.352792e-01 0.134 0 0
Bacterial Infection Pathways R-HSA-9824439 7.353346e-01 0.134 0 0
Degradation of the extracellular matrix R-HSA-1474228 7.473541e-01 0.126 0 0
Cellular response to chemical stress R-HSA-9711123 7.476713e-01 0.126 0 0
O-linked glycosylation R-HSA-5173105 7.611237e-01 0.119 0 0
Mitochondrial translation R-HSA-5368287 7.633450e-01 0.117 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.783302e-01 0.109 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.817481e-01 0.107 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.824358e-01 0.107 0 0
Signaling by NTRKs R-HSA-166520 7.864659e-01 0.104 0 0
PIP3 activates AKT signaling R-HSA-1257604 7.907198e-01 0.102 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.921833e-01 0.101 0 0
Interleukin-1 family signaling R-HSA-446652 7.943050e-01 0.100 0 0
Arachidonate metabolism R-HSA-2142753 7.943050e-01 0.100 0 0
Protein localization R-HSA-9609507 7.962197e-01 0.099 0 0
Death Receptor Signaling R-HSA-73887 7.981167e-01 0.098 0 0
HCMV Late Events R-HSA-9610379 8.037030e-01 0.095 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.055308e-01 0.094 0 0
RNA Polymerase II Transcription R-HSA-73857 8.128620e-01 0.090 0 0
SLC transporter disorders R-HSA-5619102 8.212383e-01 0.086 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.278086e-01 0.082 0 0
tRNA processing R-HSA-72306 8.278086e-01 0.082 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.310032e-01 0.080 0 0
Extracellular matrix organization R-HSA-1474244 8.380405e-01 0.077 0 0
Respiratory electron transport R-HSA-611105 8.402380e-01 0.076 0 0
Diseases of glycosylation R-HSA-3781865 8.489713e-01 0.071 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 8.493626e-01 0.071 1 0
Intracellular signaling by second messengers R-HSA-9006925 8.504546e-01 0.070 0 0
Peptide ligand-binding receptors R-HSA-375276 8.517758e-01 0.070 0 0
Signaling by Interleukins R-HSA-449147 8.522250e-01 0.069 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.545284e-01 0.068 0 0
MAPK family signaling cascades R-HSA-5683057 8.558080e-01 0.068 0 0
Ion channel transport R-HSA-983712 8.558857e-01 0.068 0 0
Co-inhibition by PD-1 R-HSA-389948 8.700101e-01 0.060 0 0
Sphingolipid metabolism R-HSA-428157 8.712238e-01 0.060 0 0
Signaling by ROBO receptors R-HSA-376176 8.736175e-01 0.059 0 0
Muscle contraction R-HSA-397014 8.849392e-01 0.053 0 0
Drug ADME R-HSA-9748784 8.912425e-01 0.050 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.019208e-01 0.045 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.028382e-01 0.044 0 0
rRNA processing R-HSA-72312 9.046477e-01 0.044 0 0
Metabolism of nucleotides R-HSA-15869 9.081668e-01 0.042 0 0
Fatty acid metabolism R-HSA-8978868 9.084449e-01 0.042 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.171931e-01 0.038 0 0
Translation R-HSA-72766 9.225803e-01 0.035 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.239184e-01 0.034 0 0
Phospholipid metabolism R-HSA-1483257 9.473221e-01 0.024 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.725716e-01 0.012 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.795611e-01 0.009 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.801353e-01 0.009 0 0
G alpha (i) signalling events R-HSA-418594 9.819360e-01 0.008 0 0
Diseases of metabolism R-HSA-5668914 9.850653e-01 0.007 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.885619e-01 0.005 0 0
Transport of small molecules R-HSA-382551 9.958623e-01 0.002 0 0
GPCR ligand binding R-HSA-500792 9.968298e-01 0.001 0 0
GPCR downstream signalling R-HSA-388396 9.994707e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.997645e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999423e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999946e-01 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 1 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 1.000000e+00 0.000 1 1
Signaling by Retinoic Acid R-HSA-5362517 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 1.507905e-11 10.822 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.041845e-11 10.517 0 0
Signal Transduction R-HSA-162582 9.425150e-11 10.026 1 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.950207e-09 8.403 0 0
HSF1-dependent transactivation R-HSA-3371571 5.286035e-09 8.277 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.093163e-09 8.215 0 0
Attenuation phase R-HSA-3371568 8.310489e-09 8.080 0 0
Cell Cycle, Mitotic R-HSA-69278 1.025848e-08 7.989 0 0
Cell Cycle R-HSA-1640170 2.632436e-08 7.580 0 0
Cell-Cell communication R-HSA-1500931 3.938585e-08 7.405 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.852383e-07 6.732 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.947260e-07 6.531 0 0
HSF1 activation R-HSA-3371511 3.460973e-07 6.461 0 0
Cell junction organization R-HSA-446728 5.811743e-07 6.236 0 0
Nervous system development R-HSA-9675108 9.209573e-07 6.036 0 0
Signaling by VEGF R-HSA-194138 1.556480e-06 5.808 0 0
Axon guidance R-HSA-422475 1.551711e-06 5.809 0 0
Apoptotic execution phase R-HSA-75153 1.450360e-06 5.839 0 0
Recycling pathway of L1 R-HSA-437239 1.992011e-06 5.701 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.134165e-06 5.671 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.134165e-06 5.671 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.354786e-06 5.628 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.473032e-06 5.607 0 0
Post NMDA receptor activation events R-HSA-438064 3.040774e-06 5.517 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.555584e-06 5.449 0 0
Signaling by ALK in cancer R-HSA-9700206 4.282988e-06 5.368 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.282988e-06 5.368 0 0
Cell-cell junction organization R-HSA-421270 5.137810e-06 5.289 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.471680e-06 5.262 0 0
Apoptosis R-HSA-109581 5.955444e-06 5.225 0 0
L1CAM interactions R-HSA-373760 6.422195e-06 5.192 0 0
Cellular responses to stimuli R-HSA-8953897 6.576583e-06 5.182 0 0
Chromatin organization R-HSA-4839726 7.364107e-06 5.133 0 0
M Phase R-HSA-68886 7.824618e-06 5.107 0 0
Programmed Cell Death R-HSA-5357801 7.763439e-06 5.110 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.095908e-05 4.960 0 0
Adherens junctions interactions R-HSA-418990 1.167823e-05 4.933 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.367278e-05 4.864 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.369417e-05 4.863 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.991801e-05 4.701 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.145113e-05 4.669 0 0
Chromatin modifying enzymes R-HSA-3247509 2.411578e-05 4.618 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.678975e-05 4.572 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.117996e-05 4.506 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.064466e-05 4.514 0 0
Separation of Sister Chromatids R-HSA-2467813 3.123390e-05 4.505 0 0
Cellular responses to stress R-HSA-2262752 3.492642e-05 4.457 0 0
mRNA Splicing R-HSA-72172 4.399406e-05 4.357 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.937214e-05 4.226 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.866775e-05 4.163 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 7.459324e-05 4.127 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.132654e-05 4.090 0 0
Nuclear Envelope Breakdown R-HSA-2980766 8.318940e-05 4.080 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.581915e-05 4.066 0 0
Mitotic Anaphase R-HSA-68882 9.799596e-05 4.009 0 0
ESR-mediated signaling R-HSA-8939211 1.036048e-04 3.985 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.094055e-04 3.961 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.375616e-04 3.862 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.612658e-04 3.792 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.668865e-04 3.778 0 0
Mitotic Prometaphase R-HSA-68877 2.024650e-04 3.694 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.370145e-04 3.625 0 0
Cellular Senescence R-HSA-2559583 2.601875e-04 3.585 0 0
Prolonged ERK activation events R-HSA-169893 2.964363e-04 3.528 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.987386e-04 3.525 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.987386e-04 3.525 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.987386e-04 3.525 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.844289e-04 3.546 0 0
Signaling by RAS mutants R-HSA-6802949 2.987386e-04 3.525 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.189409e-04 3.496 0 0
HDACs deacetylate histones R-HSA-3214815 3.395916e-04 3.469 0 0
Membrane Trafficking R-HSA-199991 3.499229e-04 3.456 0 0
Signaling by ERBB2 R-HSA-1227986 3.904612e-04 3.408 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.054465e-04 3.392 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.394917e-04 3.357 0 0
Mitotic Prophase R-HSA-68875 4.610788e-04 3.336 0 0
Cell Cycle Checkpoints R-HSA-69620 4.827779e-04 3.316 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.099535e-04 3.292 0 0
Regulation of CDH1 Function R-HSA-9764561 5.110467e-04 3.292 0 0
Interferon Signaling R-HSA-913531 5.222828e-04 3.282 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.355697e-04 3.271 0 0
ALK mutants bind TKIs R-HSA-9700645 5.689745e-04 3.245 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 5.809304e-04 3.236 0 0
Deubiquitination R-HSA-5688426 5.952716e-04 3.225 0 0
UCH proteinases R-HSA-5689603 6.282960e-04 3.202 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 7.104050e-04 3.148 0 0
Amplification of signal from the kinetochores R-HSA-141424 7.104050e-04 3.148 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.932845e-04 3.159 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.817513e-04 3.166 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.596527e-04 3.119 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.560139e-04 3.068 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 9.476314e-04 3.023 0 0
Folding of actin by CCT/TriC R-HSA-390450 9.476314e-04 3.023 0 0
Ephrin signaling R-HSA-3928664 9.226585e-04 3.035 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.672672e-04 3.014 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.030189e-03 2.987 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.101183e-03 2.958 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.113234e-03 2.953 0 0
EPH-Ephrin signaling R-HSA-2682334 1.161439e-03 2.935 0 0
RMTs methylate histone arginines R-HSA-3214858 1.230699e-03 2.910 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.230699e-03 2.910 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.270684e-03 2.896 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.305336e-03 2.884 0 0
Frs2-mediated activation R-HSA-170968 1.322086e-03 2.879 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.322086e-03 2.879 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.420120e-03 2.848 0 0
Gap junction trafficking and regulation R-HSA-157858 1.403236e-03 2.853 0 0
G2/M Transition R-HSA-69275 1.440274e-03 2.842 0 0
PECAM1 interactions R-HSA-210990 1.505537e-03 2.822 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.547402e-03 2.810 0 0
Signaling by PTK6 R-HSA-8848021 1.547402e-03 2.810 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.447062e-03 2.840 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.533731e-03 2.814 0 0
Gene expression (Transcription) R-HSA-74160 1.488937e-03 2.827 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.540310e-03 2.812 0 0
RSK activation R-HSA-444257 1.607539e-03 2.794 0 0
Formation of annular gap junctions R-HSA-196025 1.607539e-03 2.794 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.743208e-03 2.759 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.870139e-03 2.728 1 0
Regulation of KIT signaling R-HSA-1433559 1.939557e-03 2.712 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.026368e-03 2.693 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.123549e-03 2.673 0 0
Selective autophagy R-HSA-9663891 2.237162e-03 2.650 0 0
Protein folding R-HSA-391251 2.277673e-03 2.643 0 0
Signaling by SCF-KIT R-HSA-1433557 2.425266e-03 2.615 0 0
Oncogenic MAPK signaling R-HSA-6802957 2.516493e-03 2.599 0 0
Gap junction degradation R-HSA-190873 2.601320e-03 2.585 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.601320e-03 2.585 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.604665e-03 2.584 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.613695e-03 2.583 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.613695e-03 2.583 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.768062e-03 2.558 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.956109e-03 2.529 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.956109e-03 2.529 0 0
RET signaling R-HSA-8853659 2.794091e-03 2.554 0 0
Gap junction trafficking R-HSA-190828 2.942468e-03 2.531 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.085262e-03 2.511 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.389334e-03 2.470 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.389334e-03 2.470 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.389334e-03 2.470 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.389334e-03 2.470 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.389334e-03 2.470 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.389334e-03 2.470 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.389334e-03 2.470 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.389334e-03 2.470 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.389334e-03 2.470 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.389334e-03 2.470 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.389334e-03 2.470 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.381909e-03 2.471 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.161632e-03 2.500 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.161632e-03 2.500 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.443965e-03 2.463 0 0
snRNP Assembly R-HSA-191859 3.695414e-03 2.432 0 0
Metabolism of non-coding RNA R-HSA-194441 3.695414e-03 2.432 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.735917e-03 2.428 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.890129e-03 2.410 0 0
Signal attenuation R-HSA-74749 4.010460e-03 2.397 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.132623e-03 2.384 0 0
Nuclear import of Rev protein R-HSA-180746 4.544746e-03 2.342 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.856856e-03 2.314 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.856856e-03 2.314 0 0
Signaling by EGFR R-HSA-177929 4.837980e-03 2.315 0 0
PKR-mediated signaling R-HSA-9833482 4.822106e-03 2.317 0 0
Signaling by ALK R-HSA-201556 5.116124e-03 2.291 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 5.116124e-03 2.291 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.116124e-03 2.291 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.248092e-03 2.280 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.316450e-03 2.274 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.316450e-03 2.274 0 0
Signal transduction by L1 R-HSA-445144 5.380264e-03 2.269 0 0
S Phase R-HSA-69242 5.387822e-03 2.269 0 0
Signaling by NTRKs R-HSA-166520 5.387822e-03 2.269 0 0
mRNA 3'-end processing R-HSA-72187 5.396587e-03 2.268 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.565351e-03 2.255 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.873476e-03 2.231 0 0
MAPK family signaling cascades R-HSA-5683057 5.967931e-03 2.224 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.025489e-03 2.220 0 0
Regulation of TP53 Activity R-HSA-5633007 6.079928e-03 2.216 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.705801e-03 2.174 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 6.705801e-03 2.174 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.599622e-03 2.180 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.149454e-03 2.211 0 0
Semaphorin interactions R-HSA-373755 6.799134e-03 2.168 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.264104e-03 2.203 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.482979e-03 2.188 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.003711e-03 2.155 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.049080e-03 2.152 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.049080e-03 2.152 0 0
Metabolism of RNA R-HSA-8953854 7.277941e-03 2.138 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 7.358632e-03 2.133 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 7.365678e-03 2.133 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 7.512701e-03 2.124 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 7.825596e-03 2.106 0 0
Nucleosome assembly R-HSA-774815 7.904646e-03 2.102 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.904646e-03 2.102 0 0
DAG and IP3 signaling R-HSA-1489509 7.904646e-03 2.102 0 0
Ub-specific processing proteases R-HSA-5689880 7.992019e-03 2.097 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 8.009926e-03 2.096 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.156326e-03 2.089 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.935201e-03 2.049 0 0
MAP2K and MAPK activation R-HSA-5674135 8.799911e-03 2.056 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 9.176852e-03 2.037 0 0
Long-term potentiation R-HSA-9620244 8.499095e-03 2.071 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.176852e-03 2.037 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.906540e-03 2.050 0 0
Cell-extracellular matrix interactions R-HSA-446353 9.089531e-03 2.041 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.955597e-03 2.048 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.799911e-03 2.056 0 0
PTEN Regulation R-HSA-6807070 9.373172e-03 2.028 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.419792e-03 2.026 0 0
NRAGE signals death through JNK R-HSA-193648 9.990114e-03 2.000 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.018877e-02 1.992 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.031047e-02 1.987 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.041234e-02 1.982 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.041234e-02 1.982 0 0
Ca-dependent events R-HSA-111996 1.041234e-02 1.982 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.043395e-02 1.982 0 0
RAF activation R-HSA-5673000 1.080264e-02 1.966 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.080264e-02 1.966 0 0
Autophagy R-HSA-9612973 1.094511e-02 1.961 0 0
Notch-HLH transcription pathway R-HSA-350054 1.127833e-02 1.948 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.144889e-02 1.941 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.168322e-02 1.932 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.173228e-02 1.931 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.173228e-02 1.931 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.176960e-02 1.929 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.357871e-02 1.867 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.357871e-02 1.867 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.249543e-02 1.903 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.303630e-02 1.885 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.332042e-02 1.875 0 0
Oncogene Induced Senescence R-HSA-2559585 1.293274e-02 1.888 0 0
Co-stimulation by CD28 R-HSA-389356 1.271247e-02 1.896 0 0
Signalling to ERKs R-HSA-187687 1.293274e-02 1.888 0 0
PCP/CE pathway R-HSA-4086400 1.321473e-02 1.879 0 0
Aggrephagy R-HSA-9646399 1.373511e-02 1.862 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.332042e-02 1.875 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.373511e-02 1.862 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.373511e-02 1.862 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.488661e-02 1.827 0 0
RNA Polymerase II Transcription R-HSA-73857 1.495288e-02 1.825 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.498931e-02 1.824 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.498931e-02 1.824 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.500447e-02 1.824 0 0
Formation of definitive endoderm R-HSA-9823730 1.500447e-02 1.824 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.536650e-02 1.813 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.536650e-02 1.813 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.536650e-02 1.813 0 0
RUNX2 regulates bone development R-HSA-8941326 1.537221e-02 1.813 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.537221e-02 1.813 0 0
Calmodulin induced events R-HSA-111933 1.537221e-02 1.813 0 0
CaM pathway R-HSA-111997 1.537221e-02 1.813 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.581247e-02 1.801 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.581247e-02 1.801 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.581765e-02 1.801 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.581765e-02 1.801 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.581765e-02 1.801 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.876072e-02 1.727 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.876072e-02 1.727 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 1.732273e-02 1.761 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.727275e-02 1.763 0 0
Centrosome maturation R-HSA-380287 1.690625e-02 1.772 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.613491e-02 1.792 0 0
FLT3 Signaling R-HSA-9607240 1.613491e-02 1.792 0 0
Integrin signaling R-HSA-354192 1.715903e-02 1.766 0 0
HATs acetylate histones R-HSA-3214847 1.867925e-02 1.729 0 0
Macroautophagy R-HSA-1632852 1.774788e-02 1.751 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.665332e-02 1.778 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.715903e-02 1.766 0 0
Kinesins R-HSA-983189 1.727275e-02 1.763 0 0
Potential therapeutics for SARS R-HSA-9679191 1.639829e-02 1.785 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.867925e-02 1.729 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.715903e-02 1.766 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.908351e-02 1.719 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.929523e-02 1.715 0 0
Signaling by WNT R-HSA-195721 1.939815e-02 1.712 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.947669e-02 1.710 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.002115e-02 1.699 0 0
Signaling by Hippo R-HSA-2028269 2.002115e-02 1.699 0 0
Striated Muscle Contraction R-HSA-390522 2.037627e-02 1.691 0 0
Interleukin-2 signaling R-HSA-9020558 2.067099e-02 1.685 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.073894e-02 1.683 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.075901e-02 1.683 0 0
Signal regulatory protein family interactions R-HSA-391160 2.080901e-02 1.682 0 0
TCR signaling R-HSA-202403 2.115462e-02 1.675 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.128476e-02 1.672 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.160670e-02 1.665 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.160670e-02 1.665 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.222556e-02 1.653 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.240183e-02 1.650 0 0
IRS activation R-HSA-74713 2.240183e-02 1.650 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.282346e-02 1.642 0 0
Diseases of cellular response to stress R-HSA-9675132 2.328373e-02 1.633 0 0
Diseases of Cellular Senescence R-HSA-9630747 2.328373e-02 1.633 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.328373e-02 1.633 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.680214e-02 1.572 0 0
MET receptor recycling R-HSA-8875656 2.680214e-02 1.572 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.680904e-02 1.572 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.680904e-02 1.572 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.516299e-02 1.599 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.516299e-02 1.599 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.516299e-02 1.599 0 0
Downstream signal transduction R-HSA-186763 2.707246e-02 1.567 0 0
Trafficking of AMPA receptors R-HSA-399719 2.707246e-02 1.567 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.547692e-02 1.594 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.547677e-02 1.594 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.463957e-02 1.608 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.560936e-02 1.592 0 0
Neutrophil degranulation R-HSA-6798695 2.651068e-02 1.577 0 0
Adipogenesis R-HSA-9843745 2.764028e-02 1.558 0 0
RNA Polymerase I Transcription R-HSA-73864 2.365286e-02 1.626 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.417552e-02 1.617 0 0
Apoptotic factor-mediated response R-HSA-111471 2.516299e-02 1.599 0 0
G1/S Transition R-HSA-69206 2.450685e-02 1.611 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.680214e-02 1.572 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.547692e-02 1.594 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.547520e-02 1.594 0 0
Smooth Muscle Contraction R-HSA-445355 2.547677e-02 1.594 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.765782e-02 1.558 0 0
Activation of RAC1 R-HSA-428540 2.765782e-02 1.558 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.823958e-02 1.549 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.828777e-02 1.548 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.857135e-02 1.544 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.874780e-02 1.541 0 0
Interleukin-2 family signaling R-HSA-451927 2.874780e-02 1.541 0 0
Degradation of CDH1 R-HSA-9766229 2.906994e-02 1.537 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.978356e-02 1.526 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.978356e-02 1.526 0 0
MHC class II antigen presentation R-HSA-2132295 3.005011e-02 1.522 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.026223e-02 1.519 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 3.078100e-02 1.512 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.116143e-02 1.506 0 0
G0 and Early G1 R-HSA-1538133 3.186367e-02 1.497 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.186367e-02 1.497 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.210886e-02 1.493 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.312255e-02 1.480 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.312255e-02 1.480 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.328711e-02 1.478 0 0
Death Receptor Signaling R-HSA-73887 3.361186e-02 1.474 0 0
Hedgehog 'off' state R-HSA-5610787 3.380076e-02 1.471 0 0
Glycolysis R-HSA-70171 3.380076e-02 1.471 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.388893e-02 1.470 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.388893e-02 1.470 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.413284e-02 1.467 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.448834e-02 1.462 0 0
Developmental Biology R-HSA-1266738 3.554327e-02 1.449 0 0
Interleukin-15 signaling R-HSA-8983432 3.604774e-02 1.443 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.674722e-02 1.435 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 3.713527e-02 1.430 0 0
MET interacts with TNS proteins R-HSA-8875513 4.079165e-02 1.389 0 0
MET activates PTPN11 R-HSA-8865999 4.079165e-02 1.389 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 4.211226e-02 1.376 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.807101e-02 1.419 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.807101e-02 1.419 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.807101e-02 1.419 0 0
Deadenylation of mRNA R-HSA-429947 4.076038e-02 1.390 0 0
Signaling by Erythropoietin R-HSA-9006335 4.236952e-02 1.373 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.319348e-02 1.365 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.603556e-02 1.337 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.475828e-02 1.349 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.475828e-02 1.349 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.837617e-02 1.416 0 0
DNA Double Strand Break Response R-HSA-5693606 3.913189e-02 1.407 0 0
MTOR signalling R-HSA-165159 4.327141e-02 1.364 0 0
ERK/MAPK targets R-HSA-198753 4.593787e-02 1.338 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.722796e-02 1.429 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.310184e-02 1.366 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.795674e-02 1.421 0 0
G alpha (12/13) signalling events R-HSA-416482 4.064200e-02 1.391 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.780945e-02 1.422 0 0
Generic Transcription Pathway R-HSA-212436 4.023911e-02 1.395 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.020970e-02 1.396 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.722796e-02 1.429 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.203879e-02 1.376 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.777785e-02 1.423 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.120416e-02 1.385 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.689170e-02 1.329 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.820636e-02 1.317 0 0
STAT5 Activation R-HSA-9645135 4.864856e-02 1.313 0 0
Formation of apoptosome R-HSA-111458 4.870751e-02 1.312 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.870751e-02 1.312 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 4.870751e-02 1.312 0 0
Signaling by Leptin R-HSA-2586552 4.870751e-02 1.312 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.938283e-02 1.306 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.963413e-02 1.304 0 0
Insulin receptor signalling cascade R-HSA-74751 4.966241e-02 1.304 0 0
Host Interactions of HIV factors R-HSA-162909 4.970083e-02 1.304 0 0
Gap junction assembly R-HSA-190861 4.978518e-02 1.303 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 4.978518e-02 1.303 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.129110e-02 1.290 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.129110e-02 1.290 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.150362e-02 1.288 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.152829e-02 1.288 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.152829e-02 1.288 0 0
Translation initiation complex formation R-HSA-72649 5.277519e-02 1.278 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.541675e-02 1.256 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.640093e-02 1.249 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.640093e-02 1.249 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.650017e-02 1.248 0 0
Metalloprotease DUBs R-HSA-5689901 5.650017e-02 1.248 0 0
EGFR downregulation R-HSA-182971 5.713212e-02 1.243 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.713212e-02 1.243 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.730858e-02 1.242 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.730858e-02 1.242 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.805237e-02 1.236 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.827963e-02 1.234 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.827963e-02 1.234 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.827963e-02 1.234 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.827963e-02 1.234 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.827963e-02 1.234 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.077176e-02 1.216 0 0
Polo-like kinase mediated events R-HSA-156711 6.217093e-02 1.206 0 0
Signaling by FGFR3 R-HSA-5654741 6.227923e-02 1.206 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.227923e-02 1.206 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.227923e-02 1.206 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 6.269720e-02 1.203 0 0
Signaling by APC mutants R-HSA-4839744 6.269720e-02 1.203 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 6.269720e-02 1.203 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 6.269720e-02 1.203 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 6.269720e-02 1.203 0 0
Suppression of apoptosis R-HSA-9635465 6.269720e-02 1.203 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.271649e-02 1.203 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.290187e-02 1.201 0 0
PLC beta mediated events R-HSA-112043 6.290187e-02 1.201 0 0
Regulation of gap junction activity R-HSA-191650 6.328716e-02 1.199 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 6.328716e-02 1.199 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 6.328716e-02 1.199 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 6.328716e-02 1.199 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 6.328716e-02 1.199 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 6.328716e-02 1.199 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 6.328716e-02 1.199 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 6.328716e-02 1.199 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.341443e-02 1.198 0 0
PKMTs methylate histone lysines R-HSA-3214841 6.375969e-02 1.195 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 7.582843e-02 1.120 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 7.582843e-02 1.120 0 0
Manipulation of host energy metabolism R-HSA-9636667 7.582843e-02 1.120 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 7.582843e-02 1.120 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 7.582843e-02 1.120 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 7.582843e-02 1.120 0 0
IKBKB deficiency causes SCID R-HSA-5602636 7.582843e-02 1.120 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 7.582843e-02 1.120 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.617373e-02 1.179 0 0
PTK6 Expression R-HSA-8849473 6.617373e-02 1.179 0 0
Disinhibition of SNARE formation R-HSA-114516 6.617373e-02 1.179 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 8.653120e-02 1.063 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.871591e-02 1.104 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.871591e-02 1.104 0 0
Erythropoietin activates RAS R-HSA-9027284 7.025140e-02 1.153 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.025140e-02 1.153 0 0
Negative regulation of FLT3 R-HSA-9706369 8.474078e-02 1.072 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.474078e-02 1.072 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.474078e-02 1.072 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 8.474078e-02 1.072 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 7.405818e-02 1.130 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.566411e-02 1.183 0 0
Degradation of DVL R-HSA-4641258 7.351182e-02 1.134 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.496348e-02 1.071 0 0
MET promotes cell motility R-HSA-8875878 8.278235e-02 1.082 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.968541e-02 1.157 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.521753e-02 1.186 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.521753e-02 1.186 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.489877e-02 1.126 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.281215e-02 1.082 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.281215e-02 1.082 0 0
Meiotic synapsis R-HSA-1221632 8.281215e-02 1.082 0 0
HCMV Early Events R-HSA-9609690 7.840485e-02 1.106 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.935010e-02 1.159 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.929363e-02 1.101 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.686323e-02 1.175 0 0
Growth hormone receptor signaling R-HSA-982772 7.559774e-02 1.121 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.871591e-02 1.104 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.337312e-02 1.079 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 8.653120e-02 1.063 0 0
DNA Repair R-HSA-73894 8.623259e-02 1.064 0 0
Breakdown of the nuclear lamina R-HSA-352238 7.582843e-02 1.120 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.030094e-02 1.095 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.310864e-02 1.080 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.675557e-02 1.115 0 0
G2/M Checkpoints R-HSA-69481 6.569603e-02 1.182 0 0
Cilium Assembly R-HSA-5617833 7.806945e-02 1.108 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.491125e-02 1.125 0 0
Signaling by AXIN mutants R-HSA-4839735 7.871591e-02 1.104 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.489877e-02 1.126 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.665400e-02 1.062 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.665400e-02 1.062 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.665400e-02 1.062 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.665400e-02 1.062 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.710331e-02 1.060 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.710331e-02 1.060 0 0
Negative regulation of MET activity R-HSA-6807004 8.719205e-02 1.060 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 8.719205e-02 1.060 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 8.719205e-02 1.060 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 8.719205e-02 1.060 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 8.719205e-02 1.060 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 8.755708e-02 1.058 0 0
Defective pyroptosis R-HSA-9710421 8.949877e-02 1.048 0 0
Interleukin-12 signaling R-HSA-9020591 9.025463e-02 1.045 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 9.031865e-02 1.044 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 9.031865e-02 1.044 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.123958e-02 1.040 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.127462e-02 1.040 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.128090e-02 1.040 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.396995e-01 0.855 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.396995e-01 0.855 0 0
Drug resistance of ALK mutants R-HSA-9700649 1.396995e-01 0.855 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.396995e-01 0.855 0 0
KIT mutants bind TKIs R-HSA-9669921 1.396995e-01 0.855 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.396995e-01 0.855 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.396995e-01 0.855 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.396995e-01 0.855 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.396995e-01 0.855 0 0
crizotinib-resistant ALK mutants R-HSA-9717326 1.396995e-01 0.855 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.396995e-01 0.855 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.396995e-01 0.855 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.396995e-01 0.855 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.396995e-01 0.855 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.396995e-01 0.855 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.396995e-01 0.855 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.396995e-01 0.855 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.396995e-01 0.855 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.396995e-01 0.855 0 0
NVP-TAE684-resistant ALK mutants R-HSA-9717301 1.396995e-01 0.855 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.396995e-01 0.855 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.396995e-01 0.855 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.396995e-01 0.855 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.396995e-01 0.855 0 0
ceritinib-resistant ALK mutants R-HSA-9717323 1.396995e-01 0.855 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.396995e-01 0.855 0 0
brigatinib-resistant ALK mutants R-HSA-9717319 1.396995e-01 0.855 0 0
ASP-3026-resistant ALK mutants R-HSA-9717264 1.396995e-01 0.855 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.396995e-01 0.855 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.396995e-01 0.855 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.396995e-01 0.855 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.396995e-01 0.855 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.396995e-01 0.855 0 0
lorlatinib-resistant ALK mutants R-HSA-9717329 1.396995e-01 0.855 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.396995e-01 0.855 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.396995e-01 0.855 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.396995e-01 0.855 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.396995e-01 0.855 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.396995e-01 0.855 0 0
alectinib-resistant ALK mutants R-HSA-9717316 1.396995e-01 0.855 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.396995e-01 0.855 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.396995e-01 0.855 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.396995e-01 0.855 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.396995e-01 0.855 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 1.225030e-01 0.912 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.225030e-01 0.912 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.225030e-01 0.912 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.212843e-01 0.916 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.095423e-01 0.960 0 0
WNT mediated activation of DVL R-HSA-201688 1.095423e-01 0.960 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.095423e-01 0.960 0 0
Calcineurin activates NFAT R-HSA-2025928 1.095423e-01 0.960 0 0
MAPK1 (ERK2) activation R-HSA-112411 1.095423e-01 0.960 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 9.671193e-02 1.015 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 9.671193e-02 1.015 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 9.671193e-02 1.015 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 9.671193e-02 1.015 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 9.671193e-02 1.015 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 9.671193e-02 1.015 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 9.671193e-02 1.015 0 0
MAPK3 (ERK1) activation R-HSA-110056 1.349679e-01 0.870 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.349679e-01 0.870 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.349679e-01 0.870 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.165951e-01 0.933 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.165951e-01 0.933 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.165951e-01 0.933 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.165951e-01 0.933 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.165951e-01 0.933 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 1.007495e-01 0.997 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.007495e-01 0.997 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.382426e-01 0.859 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.382426e-01 0.859 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.182275e-01 0.927 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.015588e-01 0.993 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.015588e-01 0.993 0 0
GAB1 signalosome R-HSA-180292 1.371042e-01 0.863 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 1.371042e-01 0.863 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.171298e-01 0.931 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.171298e-01 0.931 0 0
TGFBR3 expression R-HSA-9839394 1.005523e-01 0.998 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 1.338622e-01 0.873 0 0
mTORC1-mediated signalling R-HSA-166208 1.338622e-01 0.873 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.579610e-02 1.019 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.579610e-02 1.019 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.112017e-01 0.954 0 0
Signaling by FGFR3 in disease R-HSA-5655332 1.295754e-01 0.887 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.295754e-01 0.887 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.033998e-01 0.985 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.197831e-01 0.922 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.147422e-01 0.940 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.001836e-01 0.999 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.324822e-01 0.878 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.367578e-01 0.864 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.082247e-01 0.966 0 0
G1 Phase R-HSA-69236 9.931900e-02 1.003 0 0
Cyclin D associated events in G1 R-HSA-69231 9.931900e-02 1.003 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.392097e-01 0.856 0 0
G-protein beta:gamma signalling R-HSA-397795 1.392097e-01 0.856 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.367578e-01 0.864 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.015588e-01 0.993 0 0
Meiosis R-HSA-1500620 1.163606e-01 0.934 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.392097e-01 0.856 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.097603e-01 0.960 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.371937e-01 0.863 0 0
GPVI-mediated activation cascade R-HSA-114604 1.197831e-01 0.922 0 0
Josephin domain DUBs R-HSA-5689877 1.349679e-01 0.870 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.848636e-02 1.007 0 0
PI3K Cascade R-HSA-109704 1.048960e-01 0.979 0 0
Rab regulation of trafficking R-HSA-9007101 9.888833e-02 1.005 0 0
Regulation of TP53 Expression R-HSA-6804754 1.225030e-01 0.912 0 0
Regulation of Apoptosis R-HSA-169911 1.074057e-01 0.969 0 0
Meiotic recombination R-HSA-912446 1.151070e-01 0.939 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.027978e-01 0.988 0 0
Myogenesis R-HSA-525793 1.145672e-01 0.941 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.579610e-02 1.019 0 0
Regulation of IFNG signaling R-HSA-877312 9.671193e-02 1.015 0 0
Synthesis of DNA R-HSA-69239 9.623224e-02 1.017 0 0
Signaling by FGFR in disease R-HSA-1226099 1.201365e-01 0.920 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.074057e-01 0.969 0 0
G-protein mediated events R-HSA-112040 1.080969e-01 0.966 0 0
Vesicle-mediated transport R-HSA-5653656 1.402204e-01 0.853 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.007495e-01 0.997 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.366156e-01 0.864 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 9.671193e-02 1.015 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.212843e-01 0.916 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.001836e-01 0.999 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.589851e-02 1.018 0 0
Signaling by NOTCH4 R-HSA-9013694 1.201365e-01 0.920 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.295754e-01 0.887 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 1.212843e-01 0.916 0 0
Unwinding of DNA R-HSA-176974 1.095423e-01 0.960 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.171298e-01 0.931 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.579610e-02 1.019 0 0
Orc1 removal from chromatin R-HSA-68949 1.258756e-01 0.900 0 0
Muscle contraction R-HSA-397014 1.005461e-01 0.998 0 0
tRNA processing in the nucleus R-HSA-6784531 1.136983e-01 0.944 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.337122e-01 0.874 0 0
Specification of primordial germ cells R-HSA-9827857 1.182275e-01 0.927 0 0
Glucose metabolism R-HSA-70326 1.402373e-01 0.853 0 0
Signaling by ROBO receptors R-HSA-376176 1.104863e-01 0.957 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.392097e-01 0.856 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.371042e-01 0.863 0 0
Gene Silencing by RNA R-HSA-211000 9.623224e-02 1.017 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.349679e-01 0.870 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.096442e-01 0.960 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.407048e-01 0.852 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.410888e-01 0.851 0 0
Cellular response to hypoxia R-HSA-1234174 1.443143e-01 0.841 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.467762e-01 0.833 0 0
Homology Directed Repair R-HSA-5693538 1.482583e-01 0.829 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.517004e-01 0.819 0 0
Syndecan interactions R-HSA-3000170 1.517004e-01 0.819 0 0
Signaling by FGFR4 R-HSA-5654743 1.527814e-01 0.816 0 0
TBC/RABGAPs R-HSA-8854214 1.527814e-01 0.816 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.538159e-01 0.813 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.544489e-01 0.811 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.555078e-01 0.808 0 0
Erythropoietin activates STAT5 R-HSA-9027283 1.555078e-01 0.808 0 0
Nef and signal transduction R-HSA-164944 1.555078e-01 0.808 0 0
CREB phosphorylation R-HSA-199920 1.555078e-01 0.808 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 1.572908e-01 0.803 0 0
Regulation of signaling by CBL R-HSA-912631 1.572908e-01 0.803 0 0
DNA Damage Bypass R-HSA-73893 1.575811e-01 0.802 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.599025e-01 0.796 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.613458e-01 0.792 0 0
Stabilization of p53 R-HSA-69541 1.613458e-01 0.792 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.615048e-01 0.792 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.615048e-01 0.792 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.615048e-01 0.792 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.615048e-01 0.792 0 0
DNA methylation R-HSA-5334118 1.624194e-01 0.789 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.625259e-01 0.789 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.625259e-01 0.789 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.625259e-01 0.789 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.645239e-01 0.784 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.645239e-01 0.784 0 0
MAP kinase activation R-HSA-450294 1.645239e-01 0.784 0 0
Co-inhibition by PD-1 R-HSA-389948 1.646399e-01 0.783 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.667391e-01 0.778 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.704650e-01 0.768 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.704650e-01 0.768 0 0
Dual Incision in GG-NER R-HSA-5696400 1.704650e-01 0.768 0 0
Mitophagy R-HSA-5205647 1.704650e-01 0.768 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.704650e-01 0.768 0 0
DNA Replication R-HSA-69306 1.710544e-01 0.767 0 0
Nucleotide Excision Repair R-HSA-5696398 1.739722e-01 0.760 0 0
TRKA activation by NGF R-HSA-187042 1.741757e-01 0.759 0 0
PLC-gamma1 signalling R-HSA-167021 1.741757e-01 0.759 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.741757e-01 0.759 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.741757e-01 0.759 0 0
Generation of second messenger molecules R-HSA-202433 1.765917e-01 0.753 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.765917e-01 0.753 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.769463e-01 0.752 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.786836e-01 0.748 0 0
Nephrin family interactions R-HSA-373753 1.786836e-01 0.748 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.789930e-01 0.747 0 0
Activation of the pre-replicative complex R-HSA-68962 1.801578e-01 0.744 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.801578e-01 0.744 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.801578e-01 0.744 0 0
Activation of BH3-only proteins R-HSA-114452 1.801578e-01 0.744 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.805675e-01 0.743 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.812961e-01 0.742 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.812961e-01 0.742 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.812961e-01 0.742 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.817520e-01 0.741 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.831982e-01 0.737 0 0
Inositol phosphate metabolism R-HSA-1483249 1.835504e-01 0.736 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.849186e-01 0.733 0 0
Phosphorylation of the APC/C R-HSA-176412 1.862111e-01 0.730 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.872153e-01 0.728 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.872153e-01 0.728 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.872153e-01 0.728 0 0
IRS-mediated signalling R-HSA-112399 1.877003e-01 0.727 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.598900e-01 0.585 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.598900e-01 0.585 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.598900e-01 0.585 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.598900e-01 0.585 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.598900e-01 0.585 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.598900e-01 0.585 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.598900e-01 0.585 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.598900e-01 0.585 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.598900e-01 0.585 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.598900e-01 0.585 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.598900e-01 0.585 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.598900e-01 0.585 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.598900e-01 0.585 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.598900e-01 0.585 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.285405e-01 0.641 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.285405e-01 0.641 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.285405e-01 0.641 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 3.632949e-01 0.440 0 0
Signaling by FGFR3 fusions in cancer R-HSA-8853334 3.632949e-01 0.440 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.632949e-01 0.440 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.632949e-01 0.440 0 0
t(4;14) translocations of FGFR3 R-HSA-2033515 3.632949e-01 0.440 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.632949e-01 0.440 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.632949e-01 0.440 0 0
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) R-HSA-5619048 3.632949e-01 0.440 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.632949e-01 0.440 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.632949e-01 0.440 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.632949e-01 0.440 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.632949e-01 0.440 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.632949e-01 0.440 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.922923e-01 0.716 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.922923e-01 0.716 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.922923e-01 0.716 0 0
SOS-mediated signalling R-HSA-112412 1.922923e-01 0.716 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.922923e-01 0.716 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.838377e-01 0.547 0 0
Activation of AKT2 R-HSA-165158 2.838377e-01 0.547 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.838377e-01 0.547 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.838377e-01 0.547 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.838377e-01 0.547 0 0
Type I hemidesmosome assembly R-HSA-446107 2.309580e-01 0.636 0 0
Interleukin-18 signaling R-HSA-9012546 2.309580e-01 0.636 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.309580e-01 0.636 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 2.309580e-01 0.636 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.919063e-01 0.717 0 0
ERKs are inactivated R-HSA-202670 1.919063e-01 0.717 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.708666e-01 0.567 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.708666e-01 0.567 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 2.708666e-01 0.567 0 0
ARMS-mediated activation R-HSA-170984 2.708666e-01 0.567 0 0
Interleukin-21 signaling R-HSA-9020958 2.708666e-01 0.567 0 0
Lipophagy R-HSA-9613354 2.708666e-01 0.567 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.387463e-01 0.470 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 3.387463e-01 0.470 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.387463e-01 0.470 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.387463e-01 0.470 0 0
Phosphorylation of Emi1 R-HSA-176417 3.387463e-01 0.470 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.387463e-01 0.470 0 0
Signaling by MAPK mutants R-HSA-9652817 3.387463e-01 0.470 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.387463e-01 0.470 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 2.548341e-01 0.594 0 0
FGFR3 mutant receptor activation R-HSA-2033514 2.548341e-01 0.594 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 2.548341e-01 0.594 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.011662e-01 0.696 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.114369e-01 0.507 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.392054e-01 0.621 0 0
Tight junction interactions R-HSA-420029 1.904160e-01 0.720 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.904160e-01 0.720 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.246130e-01 0.649 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 2.877333e-01 0.541 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.111313e-01 0.675 0 0
Signaling by KIT in disease R-HSA-9669938 2.488916e-01 0.604 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.488916e-01 0.604 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.488916e-01 0.604 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.326312e-01 0.633 0 0
Packaging Of Telomere Ends R-HSA-171306 2.326312e-01 0.633 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.211748e-01 0.493 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 3.211748e-01 0.493 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.211748e-01 0.493 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.089683e-01 0.680 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 2.775942e-01 0.557 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.246887e-01 0.489 0 0
DAP12 signaling R-HSA-2424491 3.008546e-01 0.522 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.619335e-01 0.582 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.484212e-01 0.458 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.971366e-01 0.527 0 0
Signaling by ERBB4 R-HSA-1236394 2.590184e-01 0.587 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.716193e-01 0.566 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.706860e-01 0.431 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.191420e-01 0.496 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.708141e-01 0.431 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.537655e-01 0.451 0 0
FLT3 signaling in disease R-HSA-9682385 2.046524e-01 0.689 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.176088e-01 0.662 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.170353e-01 0.663 0 0
Developmental Cell Lineages R-HSA-9734767 3.189045e-01 0.496 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.725254e-01 0.429 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 3.447111e-01 0.463 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.191420e-01 0.496 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.515839e-01 0.454 0 0
Signaling by MET R-HSA-6806834 2.576789e-01 0.589 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.801690e-01 0.553 0 0
Signaling by FGFR1 R-HSA-5654736 2.617185e-01 0.582 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.326312e-01 0.633 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.794785e-01 0.554 0 0
Downstream TCR signaling R-HSA-202424 2.418828e-01 0.616 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.838377e-01 0.547 0 0
Signaling by Insulin receptor R-HSA-74752 2.807977e-01 0.552 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.114369e-01 0.507 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.997656e-01 0.699 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.368832e-01 0.473 0 0
Signaling by WNT in cancer R-HSA-4791275 2.179708e-01 0.662 0 0
Interleukin-7 signaling R-HSA-1266695 3.253477e-01 0.488 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 1.922923e-01 0.716 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 2.838377e-01 0.547 0 0
PI3K/AKT activation R-HSA-198203 3.114369e-01 0.507 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.392054e-01 0.621 0 0
DNA strand elongation R-HSA-69190 3.484212e-01 0.458 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.448808e-01 0.462 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.032978e-01 0.692 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.708666e-01 0.567 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.725254e-01 0.429 0 0
Interleukin-9 signaling R-HSA-8985947 2.309580e-01 0.636 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.904160e-01 0.720 0 0
IGF1R signaling cascade R-HSA-2428924 2.031176e-01 0.692 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.227848e-01 0.652 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.211748e-01 0.493 0 0
Translesion Synthesis by POLH R-HSA-110320 2.956591e-01 0.529 0 0
Regulated Necrosis R-HSA-5218859 3.596295e-01 0.444 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.569137e-01 0.447 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.089683e-01 0.680 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.738655e-01 0.562 0 0
G alpha (z) signalling events R-HSA-418597 3.520197e-01 0.453 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.168271e-01 0.664 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.140405e-01 0.503 0 0
HCMV Infection R-HSA-9609646 3.174749e-01 0.498 0 0
Signaling by NOTCH3 R-HSA-9012852 3.520197e-01 0.453 0 0
Adaptive Immune System R-HSA-1280218 3.695165e-01 0.432 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.975028e-01 0.527 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.838377e-01 0.547 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 3.387463e-01 0.470 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.877333e-01 0.541 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.548702e-01 0.450 0 0
Killing mechanisms R-HSA-9664420 3.548702e-01 0.450 0 0
Intraflagellar transport R-HSA-5620924 2.282524e-01 0.642 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.001892e-01 0.523 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.725254e-01 0.429 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.738655e-01 0.562 0 0
ER-Phagosome pathway R-HSA-1236974 2.294287e-01 0.639 0 0
Signaling by NOTCH R-HSA-157118 2.868018e-01 0.542 0 0
Proteasome assembly R-HSA-9907900 2.616080e-01 0.582 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.426876e-01 0.465 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 2.708666e-01 0.567 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.387463e-01 0.470 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.111313e-01 0.675 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.779748e-01 0.423 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.537655e-01 0.451 0 0
Signaling by Interleukins R-HSA-449147 2.229282e-01 0.652 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.001892e-01 0.523 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.246130e-01 0.649 0 0
Opioid Signalling R-HSA-111885 2.883159e-01 0.540 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.114369e-01 0.507 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.227239e-01 0.652 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.246887e-01 0.489 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.768886e-01 0.558 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.619660e-01 0.441 0 0
Netrin-1 signaling R-HSA-373752 2.616080e-01 0.582 0 0
Platelet sensitization by LDL R-HSA-432142 2.670995e-01 0.573 0 0
Protein methylation R-HSA-8876725 3.211748e-01 0.493 0 0
Cleavage of the damaged purine R-HSA-110331 3.448808e-01 0.462 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.956591e-01 0.529 0 0
Cellular response to chemical stress R-HSA-9711123 3.071628e-01 0.513 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 3.001892e-01 0.523 0 0
Depurination R-HSA-73927 3.671747e-01 0.435 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.309345e-01 0.637 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.049978e-01 0.688 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.297186e-01 0.482 0 0
Inhibition of PKR R-HSA-169131 2.598900e-01 0.585 0 0
SDK interactions R-HSA-373756 2.598900e-01 0.585 0 0
MTF1 activates gene expression R-HSA-5660489 2.285405e-01 0.641 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.632949e-01 0.440 0 0
Co-inhibition by BTLA R-HSA-9927353 2.838377e-01 0.547 0 0
VEGF ligand-receptor interactions R-HSA-194313 3.387463e-01 0.470 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.387463e-01 0.470 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.877333e-01 0.541 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.179708e-01 0.662 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.924788e-01 0.716 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.227239e-01 0.652 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.779748e-01 0.423 0 0
Reproduction R-HSA-1474165 2.852529e-01 0.545 0 0
Interleukin-12 family signaling R-HSA-447115 2.053921e-01 0.687 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.706860e-01 0.431 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.179708e-01 0.662 0 0
Heme signaling R-HSA-9707616 2.611003e-01 0.583 0 0
Signaling by Hedgehog R-HSA-5358351 3.156268e-01 0.501 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 1.933417e-01 0.714 0 0
Interleukin-17 signaling R-HSA-448424 2.906696e-01 0.537 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.779748e-01 0.423 0 0
Neuronal System R-HSA-112316 3.586603e-01 0.445 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.922923e-01 0.716 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 1.922923e-01 0.716 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.387463e-01 0.470 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.211748e-01 0.493 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 3.246887e-01 0.489 0 0
Basigin interactions R-HSA-210991 3.539996e-01 0.451 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.205388e-01 0.494 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.361314e-01 0.627 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.922923e-01 0.716 0 0
TNF signaling R-HSA-75893 3.706860e-01 0.431 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.632949e-01 0.440 0 0
Inhibition of membrane repair R-HSA-9635644 3.632949e-01 0.440 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.838377e-01 0.547 0 0
SLC-mediated bile acid transport R-HSA-9958517 2.309580e-01 0.636 0 0
Physiological factors R-HSA-5578768 2.877333e-01 0.541 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 2.179708e-01 0.662 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.584376e-01 0.588 0 0
Diseases of programmed cell death R-HSA-9645723 2.172602e-01 0.663 0 0
Formation of paraxial mesoderm R-HSA-9793380 3.472799e-01 0.459 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.246130e-01 0.649 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.605427e-01 0.584 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 2.605427e-01 0.584 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.430256e-01 0.614 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.768886e-01 0.558 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.227803e-01 0.491 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.632949e-01 0.440 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.838377e-01 0.547 0 0
Sodium/Proton exchangers R-HSA-425986 2.309580e-01 0.636 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.548702e-01 0.450 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.227803e-01 0.491 0 0
Degradation of AXIN R-HSA-4641257 3.448808e-01 0.462 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.411526e-01 0.467 0 0
Depyrimidination R-HSA-73928 3.411526e-01 0.467 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.779748e-01 0.423 0 0
Sensory processing of sound R-HSA-9659379 2.440166e-01 0.613 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.448814e-01 0.611 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.448814e-01 0.611 0 0
G1/S-Specific Transcription R-HSA-69205 3.227803e-01 0.491 0 0
Diseases of DNA repair R-HSA-9675135 2.988563e-01 0.525 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.387463e-01 0.470 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.521532e-01 0.453 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.211748e-01 0.493 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.584376e-01 0.588 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.794785e-01 0.554 0 0
SARS-CoV Infections R-HSA-9679506 2.252172e-01 0.647 0 0
Regulation of beta-cell development R-HSA-186712 2.158364e-01 0.666 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.725254e-01 0.429 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.598426e-01 0.444 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.387463e-01 0.470 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 2.794785e-01 0.554 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.808128e-01 0.419 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.808128e-01 0.419 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 3.834128e-01 0.416 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.834128e-01 0.416 0 0
Circadian clock R-HSA-9909396 3.842537e-01 0.415 0 0
Transmission across Chemical Synapses R-HSA-112315 3.872045e-01 0.412 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 3.885541e-01 0.411 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.885541e-01 0.411 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 3.885541e-01 0.411 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.885541e-01 0.411 0 0
Disorders of Developmental Biology R-HSA-9675151 3.885541e-01 0.411 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.885541e-01 0.411 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.885541e-01 0.411 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.895844e-01 0.409 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.922960e-01 0.406 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.922960e-01 0.406 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.922960e-01 0.406 0 0
Neurofascin interactions R-HSA-447043 3.922960e-01 0.406 0 0
Signaling by LTK in cancer R-HSA-9842640 3.922960e-01 0.406 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 3.925682e-01 0.406 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 3.925682e-01 0.406 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.925682e-01 0.406 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.925682e-01 0.406 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.925682e-01 0.406 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.964479e-01 0.402 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.967132e-01 0.402 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.967132e-01 0.402 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.039361e-01 0.394 0 0
Somitogenesis R-HSA-9824272 4.039361e-01 0.394 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.043956e-01 0.393 0 0
Pyroptosis R-HSA-5620971 4.043956e-01 0.393 0 0
Dual incision in TC-NER R-HSA-6782135 4.083035e-01 0.389 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.120340e-01 0.385 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 4.136759e-01 0.383 0 0
Mitochondrial biogenesis R-HSA-1592230 4.151841e-01 0.382 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.163049e-01 0.381 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.208916e-01 0.376 0 0
Base Excision Repair R-HSA-73884 4.212680e-01 0.375 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.219862e-01 0.375 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.219862e-01 0.375 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.249690e-01 0.372 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.249690e-01 0.372 0 0
Signaling by TGFBR3 R-HSA-9839373 4.249690e-01 0.372 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.249690e-01 0.372 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.307286e-01 0.366 0 0
Late endosomal microautophagy R-HSA-9615710 4.307286e-01 0.366 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.307286e-01 0.366 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.323028e-01 0.364 0 0
Repression of WNT target genes R-HSA-4641265 4.323028e-01 0.364 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.323028e-01 0.364 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 4.323028e-01 0.364 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.323028e-01 0.364 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.323028e-01 0.364 0 0
p75NTR recruits signalling complexes R-HSA-209543 4.323028e-01 0.364 0 0
Pervasive developmental disorders R-HSA-9005895 4.323028e-01 0.364 0 0
Disorders of Nervous System Development R-HSA-9697154 4.323028e-01 0.364 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.323028e-01 0.364 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.344509e-01 0.362 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.344509e-01 0.362 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.353990e-01 0.361 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 4.418882e-01 0.355 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.430402e-01 0.354 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.437950e-01 0.353 0 0
Activation of TRKA receptors R-HSA-187015 4.437950e-01 0.353 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.437950e-01 0.353 0 0
Regulation of PTEN localization R-HSA-8948747 4.437950e-01 0.353 0 0
Recycling of eIF2:GDP R-HSA-72731 4.437950e-01 0.353 0 0
DAG1 core M1 glycosylations R-HSA-8932506 4.437950e-01 0.353 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 4.437950e-01 0.353 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.437950e-01 0.353 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.437950e-01 0.353 0 0
CHL1 interactions R-HSA-447041 4.437950e-01 0.353 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.437950e-01 0.353 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.437950e-01 0.353 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.448741e-01 0.352 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.459544e-01 0.351 0 0
IRE1alpha activates chaperones R-HSA-381070 4.521812e-01 0.345 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.522576e-01 0.345 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.522576e-01 0.345 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.522576e-01 0.345 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.522576e-01 0.345 0 0
Defective OPLAH causes OPLAHD R-HSA-5578998 4.522576e-01 0.345 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.522576e-01 0.345 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.522576e-01 0.345 0 0
Defective visual phototransduction due to STRA6 loss of function R-HSA-9918449 4.522576e-01 0.345 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.522576e-01 0.345 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.522576e-01 0.345 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.522576e-01 0.345 0 0
Signalling to ERK5 R-HSA-198765 4.522576e-01 0.345 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 4.522576e-01 0.345 0 0
Signaling by FGFR2 R-HSA-5654738 4.535322e-01 0.343 0 0
Tie2 Signaling R-HSA-210993 4.549532e-01 0.342 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.549532e-01 0.342 0 0
PKA activation R-HSA-163615 4.549532e-01 0.342 0 0
PKA activation in glucagon signalling R-HSA-164378 4.549532e-01 0.342 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.549532e-01 0.342 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.549532e-01 0.342 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.549532e-01 0.342 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.559463e-01 0.341 0 0
Intra-Golgi traffic R-HSA-6811438 4.567654e-01 0.340 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.567654e-01 0.340 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.567654e-01 0.340 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 4.568636e-01 0.340 0 0
Interleukin-37 signaling R-HSA-9008059 4.568636e-01 0.340 0 0
GPER1 signaling R-HSA-9634597 4.668360e-01 0.331 0 0
Chromosome Maintenance R-HSA-73886 4.688332e-01 0.329 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.706549e-01 0.327 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.706549e-01 0.327 0 0
Formation of axial mesoderm R-HSA-9796292 4.710434e-01 0.327 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 4.710434e-01 0.327 0 0
Interleukin-6 signaling R-HSA-1059683 4.710434e-01 0.327 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.710434e-01 0.327 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.710434e-01 0.327 0 0
Maturation of nucleoprotein R-HSA-9683610 4.710434e-01 0.327 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.710434e-01 0.327 0 0
Signaling by FGFR R-HSA-190236 4.739028e-01 0.324 0 0
Signaling by PDGF R-HSA-186797 4.834586e-01 0.316 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 4.872691e-01 0.312 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.872691e-01 0.312 0 0
Other interleukin signaling R-HSA-449836 4.872691e-01 0.312 0 0
STING mediated induction of host immune responses R-HSA-1834941 4.872691e-01 0.312 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.925115e-01 0.308 0 0
Immune System R-HSA-168256 4.925229e-01 0.308 0 0
phospho-PLA2 pathway R-HSA-111995 4.927712e-01 0.307 0 0
DAG1 core M2 glycosylations R-HSA-8932504 4.927712e-01 0.307 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.927712e-01 0.307 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.927712e-01 0.307 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.927712e-01 0.307 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.927712e-01 0.307 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.927712e-01 0.307 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.927712e-01 0.307 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.927712e-01 0.307 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.944181e-01 0.306 0 0
Ion homeostasis R-HSA-5578775 4.951746e-01 0.305 0 0
Parasite infection R-HSA-9664407 4.966454e-01 0.304 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.966454e-01 0.304 0 0
Leishmania phagocytosis R-HSA-9664417 4.966454e-01 0.304 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 4.989347e-01 0.302 0 0
HDMs demethylate histones R-HSA-3214842 4.989347e-01 0.302 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.008284e-01 0.300 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.081776e-01 0.294 0 0
Prolactin receptor signaling R-HSA-1170546 5.085374e-01 0.294 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.085374e-01 0.294 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.085374e-01 0.294 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.085374e-01 0.294 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.085374e-01 0.294 0 0
Signaling by TGFB family members R-HSA-9006936 5.092966e-01 0.293 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.132825e-01 0.290 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.158218e-01 0.288 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.158218e-01 0.288 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 5.187746e-01 0.285 0 0
MET activates PTK2 signaling R-HSA-8874081 5.266161e-01 0.279 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.266161e-01 0.279 0 0
TRP channels R-HSA-3295583 5.266161e-01 0.279 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.283377e-01 0.277 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.287946e-01 0.277 0 0
Axonal growth stimulation R-HSA-209563 5.287946e-01 0.277 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.287946e-01 0.277 0 0
Defective gamma-carboxylation of F9 R-HSA-9673240 5.287946e-01 0.277 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 5.287946e-01 0.277 0 0
Signalling to STAT3 R-HSA-198745 5.287946e-01 0.277 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.287946e-01 0.277 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 5.287946e-01 0.277 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 5.287946e-01 0.277 0 0
FasL/ CD95L signaling R-HSA-75157 5.287946e-01 0.277 0 0
MET activates STAT3 R-HSA-8875791 5.287946e-01 0.277 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 5.287946e-01 0.277 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.287946e-01 0.277 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.287946e-01 0.277 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.287946e-01 0.277 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.305975e-01 0.275 0 0
PI Metabolism R-HSA-1483255 5.328888e-01 0.273 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.331114e-01 0.273 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.331114e-01 0.273 0 0
HIV Infection R-HSA-162906 5.332772e-01 0.273 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.336423e-01 0.273 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.389242e-01 0.268 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.389242e-01 0.268 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 5.389242e-01 0.268 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 5.389242e-01 0.268 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.389242e-01 0.268 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 5.389242e-01 0.268 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 5.389242e-01 0.268 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.389242e-01 0.268 0 0
Cellular response to mitochondrial stress R-HSA-9840373 5.389242e-01 0.268 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 5.389242e-01 0.268 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.437481e-01 0.265 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.437481e-01 0.265 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.445879e-01 0.264 0 0
FGFR3 ligand binding and activation R-HSA-190239 5.445879e-01 0.264 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.445879e-01 0.264 0 0
DCC mediated attractive signaling R-HSA-418885 5.445879e-01 0.264 0 0
Translesion synthesis by REV1 R-HSA-110312 5.445879e-01 0.264 0 0
p75NTR signals via NF-kB R-HSA-193639 5.445879e-01 0.264 0 0
Other semaphorin interactions R-HSA-416700 5.445879e-01 0.264 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.471636e-01 0.262 0 0
Neurexins and neuroligins R-HSA-6794361 5.483001e-01 0.261 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.493364e-01 0.260 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 5.493364e-01 0.260 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.493364e-01 0.260 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.536024e-01 0.257 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.536024e-01 0.257 0 0
Hemostasis R-HSA-109582 5.548804e-01 0.256 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.578192e-01 0.254 0 0
Diseases of Immune System R-HSA-5260271 5.611974e-01 0.251 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.611974e-01 0.251 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.646503e-01 0.248 0 0
Toll-like Receptor Cascades R-HSA-168898 5.668986e-01 0.246 0 0
Interleukin-1 family signaling R-HSA-446652 5.727230e-01 0.242 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 5.788460e-01 0.237 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.788460e-01 0.237 0 0
Ribavirin ADME R-HSA-9755088 5.788460e-01 0.237 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 5.788460e-01 0.237 0 0
Translesion synthesis by POLI R-HSA-5656121 5.790476e-01 0.237 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 5.790476e-01 0.237 0 0
Differentiation of T cells R-HSA-9945266 5.790476e-01 0.237 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 5.790476e-01 0.237 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.790476e-01 0.237 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.798115e-01 0.237 0 0
Signal amplification R-HSA-392518 5.813367e-01 0.236 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.820868e-01 0.235 0 0
Regulation of CDH11 function R-HSA-9762292 5.820868e-01 0.235 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 5.820868e-01 0.235 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 5.820868e-01 0.235 0 0
Pexophagy R-HSA-9664873 5.820868e-01 0.235 0 0
Interleukin-27 signaling R-HSA-9020956 5.820868e-01 0.235 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.820868e-01 0.235 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.851215e-01 0.233 0 0
Synthesis of PC R-HSA-1483191 5.851215e-01 0.233 0 0
FOXO-mediated transcription R-HSA-9614085 5.873987e-01 0.231 0 0
Protein ubiquitination R-HSA-8852135 5.934526e-01 0.227 0 0
HCN channels R-HSA-1296061 5.946407e-01 0.226 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.946407e-01 0.226 0 0
Nucleotide catabolism defects R-HSA-9735786 5.946407e-01 0.226 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.946407e-01 0.226 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.946407e-01 0.226 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 5.946407e-01 0.226 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.946407e-01 0.226 0 0
Signaling by LRP5 mutants R-HSA-5339717 5.946407e-01 0.226 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.946407e-01 0.226 0 0
MDK and PTN in ALK signaling R-HSA-9851151 5.946407e-01 0.226 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.946407e-01 0.226 0 0
Transmission across Electrical Synapses R-HSA-112307 5.946407e-01 0.226 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.946407e-01 0.226 0 0
Sensory perception of sour taste R-HSA-9729555 5.946407e-01 0.226 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.044734e-01 0.219 0 0
PERK regulates gene expression R-HSA-381042 6.044734e-01 0.219 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.051747e-01 0.218 0 0
Platelet calcium homeostasis R-HSA-418360 6.051747e-01 0.218 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.072177e-01 0.217 0 0
LDL clearance R-HSA-8964038 6.072177e-01 0.217 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.072177e-01 0.217 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.072177e-01 0.217 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.083636e-01 0.216 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.111429e-01 0.214 0 0
Translesion synthesis by POLK R-HSA-5655862 6.118134e-01 0.213 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.118134e-01 0.213 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.118134e-01 0.213 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.118134e-01 0.213 0 0
Interleukin-1 signaling R-HSA-9020702 6.156630e-01 0.211 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.203244e-01 0.207 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.203244e-01 0.207 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 6.221935e-01 0.206 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 6.221935e-01 0.206 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.221935e-01 0.206 0 0
Bicarbonate transporters R-HSA-425381 6.221935e-01 0.206 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 6.221935e-01 0.206 0 0
Dissolution of Fibrin Clot R-HSA-75205 6.221935e-01 0.206 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.245805e-01 0.204 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.268945e-01 0.203 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.283822e-01 0.202 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.296369e-01 0.201 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.296369e-01 0.201 0 0
Interleukin-20 family signaling R-HSA-8854691 6.343870e-01 0.198 0 0
Formation of the ureteric bud R-HSA-9830674 6.343870e-01 0.198 0 0
Hedgehog 'on' state R-HSA-5632684 6.413134e-01 0.193 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.416380e-01 0.193 0 0
Ion transport by P-type ATPases R-HSA-936837 6.416380e-01 0.193 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.428200e-01 0.192 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.428200e-01 0.192 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.445261e-01 0.191 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.455512e-01 0.190 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.472441e-01 0.189 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.482283e-01 0.188 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.512887e-01 0.186 0 0
PTK6 Down-Regulation R-HSA-8849472 6.512887e-01 0.186 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 6.512887e-01 0.186 0 0
Defective F9 activation R-HSA-9673221 6.512887e-01 0.186 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.512887e-01 0.186 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.512887e-01 0.186 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.512887e-01 0.186 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.512887e-01 0.186 0 0
Activation of C3 and C5 R-HSA-174577 6.512887e-01 0.186 0 0
PTK6 Activates STAT3 R-HSA-8849474 6.512887e-01 0.186 0 0
Reelin signalling pathway R-HSA-8866376 6.512887e-01 0.186 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.512887e-01 0.186 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.512887e-01 0.186 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.512887e-01 0.186 0 0
Interferon gamma signaling R-HSA-877300 6.513299e-01 0.186 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.525812e-01 0.185 0 0
Molecules associated with elastic fibres R-HSA-2129379 6.531549e-01 0.185 0 0
Parasitic Infection Pathways R-HSA-9824443 6.549064e-01 0.184 0 0
Leishmania infection R-HSA-9658195 6.549064e-01 0.184 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.576015e-01 0.182 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.576015e-01 0.182 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.592555e-01 0.181 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.592555e-01 0.181 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.592555e-01 0.181 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 6.592555e-01 0.181 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 6.592555e-01 0.181 0 0
NF-kB is activated and signals survival R-HSA-209560 6.592555e-01 0.181 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.603087e-01 0.180 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.603087e-01 0.180 0 0
Interleukin-6 family signaling R-HSA-6783589 6.603087e-01 0.180 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.603087e-01 0.180 0 0
DAP12 interactions R-HSA-2172127 6.650849e-01 0.177 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 6.695289e-01 0.174 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 6.695289e-01 0.174 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 6.695289e-01 0.174 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.712616e-01 0.173 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.720347e-01 0.173 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.720347e-01 0.173 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.720347e-01 0.173 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.798280e-01 0.168 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.839444e-01 0.165 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.849546e-01 0.164 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.849546e-01 0.164 0 0
G protein gated Potassium channels R-HSA-1296059 6.849546e-01 0.164 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.849546e-01 0.164 0 0
Laminin interactions R-HSA-3000157 6.849546e-01 0.164 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.895215e-01 0.161 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.931827e-01 0.159 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.931827e-01 0.159 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.931827e-01 0.159 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.931827e-01 0.159 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.931827e-01 0.159 0 0
MET activates RAS signaling R-HSA-8851805 6.933403e-01 0.159 0 0
Leading Strand Synthesis R-HSA-69109 6.933403e-01 0.159 0 0
Polymerase switching R-HSA-69091 6.933403e-01 0.159 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.933403e-01 0.159 0 0
Interleukin-35 Signalling R-HSA-8984722 6.933403e-01 0.159 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.933403e-01 0.159 0 0
Signaling by LTK R-HSA-9842663 6.933403e-01 0.159 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.933403e-01 0.159 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.933403e-01 0.159 0 0
OAS antiviral response R-HSA-8983711 6.933403e-01 0.159 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.970659e-01 0.157 0 0
Nuclear RNA decay R-HSA-9930044 6.972428e-01 0.157 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.994522e-01 0.155 0 0
The NLRP3 inflammasome R-HSA-844456 6.994522e-01 0.155 0 0
Maturation of nucleoprotein R-HSA-9694631 6.994522e-01 0.155 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 7.000231e-01 0.155 0 0
NGF-independant TRKA activation R-HSA-187024 7.000231e-01 0.155 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.000231e-01 0.155 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 7.000231e-01 0.155 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 7.000231e-01 0.155 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.000231e-01 0.155 0 0
Signaling by RNF43 mutants R-HSA-5340588 7.000231e-01 0.155 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 7.000231e-01 0.155 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 7.000231e-01 0.155 0 0
TRAIL signaling R-HSA-75158 7.000231e-01 0.155 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 7.000231e-01 0.155 0 0
PKB-mediated events R-HSA-109703 7.000231e-01 0.155 0 0
PDE3B signalling R-HSA-165160 7.000231e-01 0.155 0 0
Synthesis of PS R-HSA-1483101 7.000231e-01 0.155 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 7.000231e-01 0.155 0 0
Threonine catabolism R-HSA-8849175 7.000231e-01 0.155 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 7.000231e-01 0.155 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 7.000231e-01 0.155 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 7.000231e-01 0.155 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 7.000231e-01 0.155 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 7.000231e-01 0.155 0 0
HCMV Late Events R-HSA-9610379 7.028104e-01 0.153 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.083118e-01 0.150 0 0
Aquaporin-mediated transport R-HSA-445717 7.090807e-01 0.149 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.186373e-01 0.143 0 0
Influenza Infection R-HSA-168255 7.217002e-01 0.142 0 0
Mitochondrial protein import R-HSA-1268020 7.244380e-01 0.140 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.245563e-01 0.140 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 7.245563e-01 0.140 0 0
Signaling by NODAL R-HSA-1181150 7.250896e-01 0.140 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.285966e-01 0.138 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.302268e-01 0.137 0 0
Cristae formation R-HSA-8949613 7.303807e-01 0.136 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 7.303807e-01 0.136 0 0
NGF-stimulated transcription R-HSA-9031628 7.363374e-01 0.133 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.373054e-01 0.132 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.373054e-01 0.132 0 0
Interferon alpha/beta signaling R-HSA-909733 7.396186e-01 0.131 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.419491e-01 0.130 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 7.419491e-01 0.130 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.419491e-01 0.130 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 7.419491e-01 0.130 0 0
MET Receptor Activation R-HSA-6806942 7.419491e-01 0.130 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.419491e-01 0.130 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.419491e-01 0.130 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.419491e-01 0.130 0 0
Abacavir transmembrane transport R-HSA-2161517 7.419491e-01 0.130 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.419491e-01 0.130 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 7.419491e-01 0.130 0 0
NADPH regeneration R-HSA-389542 7.419491e-01 0.130 0 0
HDL clearance R-HSA-8964011 7.419491e-01 0.130 0 0
Lipid particle organization R-HSA-8964572 7.419491e-01 0.130 0 0
Integrin cell surface interactions R-HSA-216083 7.438435e-01 0.129 0 0
Lagging Strand Synthesis R-HSA-69186 7.489823e-01 0.126 0 0
G-protein activation R-HSA-202040 7.489823e-01 0.126 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.489823e-01 0.126 0 0
Signalling to RAS R-HSA-167044 7.489823e-01 0.126 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.489823e-01 0.126 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.489823e-01 0.126 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 7.515112e-01 0.124 0 0
FGFR3c ligand binding and activation R-HSA-190372 7.530393e-01 0.123 0 0
Removal of the Flap Intermediate R-HSA-69166 7.530393e-01 0.123 0 0
Malate-aspartate shuttle R-HSA-9856872 7.530393e-01 0.123 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.558237e-01 0.122 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.615434e-01 0.118 0 0
Gastrulation R-HSA-9758941 7.618524e-01 0.118 0 0
Azathioprine ADME R-HSA-9748787 7.677185e-01 0.115 0 0
DARPP-32 events R-HSA-180024 7.707095e-01 0.113 0 0
Glucagon-type ligand receptors R-HSA-420092 7.707095e-01 0.113 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.711804e-01 0.113 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.711804e-01 0.113 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.724397e-01 0.112 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.735104e-01 0.112 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.764186e-01 0.110 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.780173e-01 0.109 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 7.780173e-01 0.109 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.780173e-01 0.109 0 0
FGFR3b ligand binding and activation R-HSA-190371 7.780173e-01 0.109 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.780173e-01 0.109 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 7.780173e-01 0.109 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.780173e-01 0.109 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.780173e-01 0.109 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.780173e-01 0.109 0 0
Reuptake of GABA R-HSA-888593 7.780173e-01 0.109 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.780173e-01 0.109 0 0
VLDL clearance R-HSA-8964046 7.780173e-01 0.109 0 0
Ca2+ activated K+ channels R-HSA-1296052 7.780173e-01 0.109 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.780173e-01 0.109 0 0
Netrin mediated repulsion signals R-HSA-418886 7.780173e-01 0.109 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.780173e-01 0.109 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.780173e-01 0.109 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.789435e-01 0.108 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.789435e-01 0.108 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.789435e-01 0.108 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.789435e-01 0.108 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.789435e-01 0.108 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.789435e-01 0.108 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 7.789435e-01 0.108 0 0
Signaling by Activin R-HSA-1502540 7.789435e-01 0.108 0 0
Ribosome-associated quality control R-HSA-9948299 7.832673e-01 0.106 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.890203e-01 0.103 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.917453e-01 0.101 0 0
FGFR2 alternative splicing R-HSA-6803529 7.917453e-01 0.101 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.917453e-01 0.101 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.917453e-01 0.101 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.962795e-01 0.099 0 0
Metabolism of polyamines R-HSA-351202 8.005182e-01 0.097 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.024332e-01 0.096 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.024332e-01 0.096 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.024332e-01 0.096 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.024332e-01 0.096 0 0
Elastic fibre formation R-HSA-1566948 8.054735e-01 0.094 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.054735e-01 0.094 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.061410e-01 0.094 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.069025e-01 0.093 0 0
Regulation by c-FLIP R-HSA-3371378 8.090461e-01 0.092 0 0
Dimerization of procaspase-8 R-HSA-69416 8.090461e-01 0.092 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 8.090461e-01 0.092 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.090461e-01 0.092 0 0
Interleukin-23 signaling R-HSA-9020933 8.090461e-01 0.092 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 8.090461e-01 0.092 0 0
Adrenoceptors R-HSA-390696 8.090461e-01 0.092 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 8.090461e-01 0.092 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 8.090461e-01 0.092 0 0
Signaling by NOTCH1 R-HSA-1980143 8.097262e-01 0.092 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.204340e-01 0.086 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.220943e-01 0.085 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.221128e-01 0.085 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.236772e-01 0.084 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.236772e-01 0.084 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.236772e-01 0.084 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 8.236772e-01 0.084 0 0
Coenzyme A biosynthesis R-HSA-196783 8.236772e-01 0.084 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.236772e-01 0.084 0 0
Passive transport by Aquaporins R-HSA-432047 8.236772e-01 0.084 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.236772e-01 0.084 0 0
Response to metal ions R-HSA-5660526 8.236772e-01 0.084 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.249044e-01 0.084 0 0
HIV Life Cycle R-HSA-162587 8.275871e-01 0.082 0 0
Integration of energy metabolism R-HSA-163685 8.275985e-01 0.082 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.282594e-01 0.082 0 0
Complex III assembly R-HSA-9865881 8.282594e-01 0.082 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.282594e-01 0.082 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 8.282594e-01 0.082 0 0
Neurodegenerative Diseases R-HSA-8863678 8.282594e-01 0.082 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.352617e-01 0.078 0 0
CASP8 activity is inhibited R-HSA-5218900 8.357391e-01 0.078 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.357391e-01 0.078 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 8.357391e-01 0.078 0 0
Enzymatic degradation of Dopamine by monoamine oxidase R-HSA-379398 8.357391e-01 0.078 0 0
Interleukin-1 processing R-HSA-448706 8.357391e-01 0.078 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.357391e-01 0.078 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 8.357391e-01 0.078 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.357391e-01 0.078 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.357391e-01 0.078 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 8.357391e-01 0.078 0 0
Cardiogenesis R-HSA-9733709 8.369810e-01 0.077 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.428441e-01 0.074 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.428441e-01 0.074 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.428441e-01 0.074 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.428441e-01 0.074 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.428441e-01 0.074 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.428441e-01 0.074 0 0
Choline catabolism R-HSA-6798163 8.428441e-01 0.074 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.428441e-01 0.074 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.443634e-01 0.073 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.443634e-01 0.073 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.443634e-01 0.073 0 0
Gluconeogenesis R-HSA-70263 8.452324e-01 0.073 0 0
Metal ion SLC transporters R-HSA-425410 8.452324e-01 0.073 0 0
Platelet homeostasis R-HSA-418346 8.454646e-01 0.073 0 0
ABC-family proteins mediated transport R-HSA-382556 8.501964e-01 0.070 0 0
Platelet degranulation R-HSA-114608 8.563909e-01 0.067 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.566289e-01 0.067 0 0
Ca2+ pathway R-HSA-4086398 8.575561e-01 0.067 0 0
Binding and entry of HIV virion R-HSA-173107 8.587021e-01 0.066 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.587021e-01 0.066 0 0
Enzymatic degradation of dopamine by COMT R-HSA-379397 8.587021e-01 0.066 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.587021e-01 0.066 0 0
DNA replication initiation R-HSA-68952 8.587021e-01 0.066 0 0
2-LTR circle formation R-HSA-164843 8.587021e-01 0.066 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.587021e-01 0.066 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.587021e-01 0.066 0 0
Tandem pore domain potassium channels R-HSA-1296346 8.587021e-01 0.066 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.591400e-01 0.066 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.591400e-01 0.066 0 0
Amyloid fiber formation R-HSA-977225 8.592422e-01 0.066 0 0
Mismatch Repair R-HSA-5358508 8.600995e-01 0.065 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.600995e-01 0.065 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.600995e-01 0.065 0 0
Nephron development R-HSA-9831926 8.600995e-01 0.065 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.659665e-01 0.062 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.671703e-01 0.062 0 0
GABA B receptor activation R-HSA-977444 8.700330e-01 0.060 0 0
Activation of GABAB receptors R-HSA-991365 8.700330e-01 0.060 0 0
Viral Infection Pathways R-HSA-9824446 8.702235e-01 0.060 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 8.726710e-01 0.059 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 8.726710e-01 0.059 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 8.726710e-01 0.059 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 8.756032e-01 0.058 0 0
Rap1 signalling R-HSA-392517 8.756032e-01 0.058 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.756032e-01 0.058 0 0
Diseases of hemostasis R-HSA-9671793 8.756032e-01 0.058 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.784562e-01 0.056 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.784562e-01 0.056 0 0
vRNA Synthesis R-HSA-192814 8.784562e-01 0.056 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.784562e-01 0.056 0 0
vRNP Assembly R-HSA-192905 8.784562e-01 0.056 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.784562e-01 0.056 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.784562e-01 0.056 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.843284e-01 0.053 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.850379e-01 0.053 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.850379e-01 0.053 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.850379e-01 0.053 0 0
HIV elongation arrest and recovery R-HSA-167287 8.850379e-01 0.053 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.850379e-01 0.053 0 0
Pyrimidine salvage R-HSA-73614 8.850379e-01 0.053 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.850379e-01 0.053 0 0
Inflammasomes R-HSA-622312 8.850379e-01 0.053 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.850379e-01 0.053 0 0
Telomere Maintenance R-HSA-157579 8.857664e-01 0.053 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.864047e-01 0.052 0 0
RNA Polymerase III Transcription R-HSA-74158 8.864047e-01 0.052 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.864576e-01 0.052 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.864576e-01 0.052 0 0
RSV-host interactions R-HSA-9833110 8.872279e-01 0.052 0 0
Cardiac conduction R-HSA-5576891 8.887459e-01 0.051 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 8.895075e-01 0.051 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.895075e-01 0.051 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.895075e-01 0.051 0 0
Creatine metabolism R-HSA-71288 8.895075e-01 0.051 0 0
Protein hydroxylation R-HSA-9629569 8.895075e-01 0.051 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.901189e-01 0.051 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.924824e-01 0.049 0 0
Gamma-carboxylation of protein precursors R-HSA-159740 8.954495e-01 0.048 0 0
DS-GAG biosynthesis R-HSA-2022923 8.954495e-01 0.048 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.954495e-01 0.048 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.954495e-01 0.048 0 0
Integration of provirus R-HSA-162592 8.954495e-01 0.048 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.954495e-01 0.048 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.954495e-01 0.048 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.954495e-01 0.048 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.954495e-01 0.048 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.954495e-01 0.048 0 0
Plasmalogen biosynthesis R-HSA-75896 8.954495e-01 0.048 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.954495e-01 0.048 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.954495e-01 0.048 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.963206e-01 0.048 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.963206e-01 0.048 1 1
Voltage gated Potassium channels R-HSA-1296072 8.965051e-01 0.047 0 0
ABC transporter disorders R-HSA-5619084 8.980995e-01 0.047 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.982188e-01 0.047 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.005361e-01 0.045 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.019566e-01 0.045 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.019566e-01 0.045 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.019566e-01 0.045 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.019566e-01 0.045 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.044937e-01 0.044 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.065967e-01 0.043 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 9.100677e-01 0.041 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 9.100677e-01 0.041 0 0
Scavenging by Class F Receptors R-HSA-3000484 9.100677e-01 0.041 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.100677e-01 0.041 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 9.100677e-01 0.041 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 9.100677e-01 0.041 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 9.100677e-01 0.041 0 0
Synthesis of GDP-mannose R-HSA-446205 9.100677e-01 0.041 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 9.100677e-01 0.041 0 0
Stimuli-sensing channels R-HSA-2672351 9.111967e-01 0.040 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.130855e-01 0.039 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.130855e-01 0.039 0 0
Attachment and Entry R-HSA-9694614 9.130855e-01 0.039 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.130855e-01 0.039 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 9.143586e-01 0.039 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.143586e-01 0.039 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.154692e-01 0.038 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.159411e-01 0.038 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.159411e-01 0.038 0 0
Budding and maturation of HIV virion R-HSA-162588 9.159411e-01 0.038 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.208193e-01 0.036 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.215536e-01 0.035 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 9.222107e-01 0.035 0 0
HIV Transcription Elongation R-HSA-167169 9.222107e-01 0.035 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 9.222107e-01 0.035 0 0
Glycogen metabolism R-HSA-8982491 9.222107e-01 0.035 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.226428e-01 0.035 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.226428e-01 0.035 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.226428e-01 0.035 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.226428e-01 0.035 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.226428e-01 0.035 0 0
Diseases of nucleotide metabolism R-HSA-9735804 9.226428e-01 0.035 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.226428e-01 0.035 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 9.226428e-01 0.035 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 9.226428e-01 0.035 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.226428e-01 0.035 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.230199e-01 0.035 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.230199e-01 0.035 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 9.230199e-01 0.035 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.230199e-01 0.035 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.247869e-01 0.034 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.262868e-01 0.033 0 0
Potassium Channels R-HSA-1296071 9.266219e-01 0.033 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.294098e-01 0.032 0 0
Protein localization R-HSA-9609507 9.298040e-01 0.032 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.307650e-01 0.031 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.307650e-01 0.031 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.318762e-01 0.031 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.318762e-01 0.031 0 0
Carnitine shuttle R-HSA-200425 9.318762e-01 0.031 0 0
Kidney development R-HSA-9830369 9.328131e-01 0.030 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 9.334602e-01 0.030 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.334602e-01 0.030 0 0
Hydrolysis of LPC R-HSA-1483115 9.334602e-01 0.030 0 0
NRIF signals cell death from the nucleus R-HSA-205043 9.334602e-01 0.030 0 0
cGMP effects R-HSA-418457 9.334602e-01 0.030 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.334602e-01 0.030 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.334602e-01 0.030 0 0
Ciprofloxacin ADME R-HSA-9793528 9.334602e-01 0.030 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.334602e-01 0.030 0 0
Zinc transporters R-HSA-435354 9.334602e-01 0.030 0 0
P2Y receptors R-HSA-417957 9.334602e-01 0.030 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.334602e-01 0.030 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.360014e-01 0.029 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.386175e-01 0.028 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.390827e-01 0.027 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.390827e-01 0.027 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.390827e-01 0.027 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.390827e-01 0.027 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.397617e-01 0.027 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.397617e-01 0.027 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.427654e-01 0.026 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.427654e-01 0.026 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.427654e-01 0.026 0 0
p38MAPK events R-HSA-171007 9.427654e-01 0.026 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.427654e-01 0.026 0 0
Protein repair R-HSA-5676934 9.427654e-01 0.026 0 0
Signaling by NOTCH2 R-HSA-1980145 9.453808e-01 0.024 0 0
Innate Immune System R-HSA-168249 9.454413e-01 0.024 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.467745e-01 0.024 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.467745e-01 0.024 0 0
Formation of the nephric duct R-HSA-9830364 9.467745e-01 0.024 0 0
Ion channel transport R-HSA-983712 9.489999e-01 0.023 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.507698e-01 0.022 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.507698e-01 0.022 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.507698e-01 0.022 0 0
Phase 4 - resting membrane potential R-HSA-5576886 9.507698e-01 0.022 0 0
Regulation of BACH1 activity R-HSA-9708530 9.507698e-01 0.022 0 0
Activation of SMO R-HSA-5635838 9.507698e-01 0.022 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.507698e-01 0.022 0 0
Attachment and Entry R-HSA-9678110 9.507698e-01 0.022 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.522689e-01 0.021 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.523841e-01 0.021 0 0
Surfactant metabolism R-HSA-5683826 9.525563e-01 0.021 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.527459e-01 0.021 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 9.530046e-01 0.021 0 0
Abacavir ADME R-HSA-2161522 9.530046e-01 0.021 0 0
Peptide chain elongation R-HSA-156902 9.543704e-01 0.020 0 0
Fibronectin matrix formation R-HSA-1566977 9.576551e-01 0.019 0 0
Phase 2 - plateau phase R-HSA-5576893 9.576551e-01 0.019 0 0
Synthesis of PG R-HSA-1483148 9.576551e-01 0.019 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.576551e-01 0.019 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.576551e-01 0.019 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.585336e-01 0.018 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.585336e-01 0.018 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.585336e-01 0.018 0 0
Insulin processing R-HSA-264876 9.585336e-01 0.018 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.598745e-01 0.018 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.608235e-01 0.017 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.612973e-01 0.017 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.612973e-01 0.017 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.612973e-01 0.017 1 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.629887e-01 0.016 0 0
G alpha (q) signalling events R-HSA-416476 9.634154e-01 0.016 0 0
Insulin receptor recycling R-HSA-77387 9.634357e-01 0.016 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.635779e-01 0.016 0 0
Glycogen storage diseases R-HSA-3229121 9.635779e-01 0.016 0 0
Catecholamine biosynthesis R-HSA-209905 9.635779e-01 0.016 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.635779e-01 0.016 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.635779e-01 0.016 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.638712e-01 0.016 0 0
Regulation of insulin secretion R-HSA-422356 9.649809e-01 0.015 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.649853e-01 0.015 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.655449e-01 0.015 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.666183e-01 0.015 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.675763e-01 0.014 0 0
mRNA Capping R-HSA-72086 9.677781e-01 0.014 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.686725e-01 0.014 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.686725e-01 0.014 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.686725e-01 0.014 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.686725e-01 0.014 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.686725e-01 0.014 0 0
Pentose phosphate pathway R-HSA-71336 9.687276e-01 0.014 0 0
Neurotransmitter clearance R-HSA-112311 9.716214e-01 0.013 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.716214e-01 0.013 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.719476e-01 0.012 0 0
Peroxisomal protein import R-HSA-9033241 9.724780e-01 0.012 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.730547e-01 0.012 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.730547e-01 0.012 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.730547e-01 0.012 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.730547e-01 0.012 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.730547e-01 0.012 0 0
Methionine salvage pathway R-HSA-1237112 9.730547e-01 0.012 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.730547e-01 0.012 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.730547e-01 0.012 0 0
Interleukin-10 signaling R-HSA-6783783 9.734837e-01 0.012 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.734837e-01 0.012 0 0
Mitochondrial protein degradation R-HSA-9837999 9.737647e-01 0.012 1 1
GABA receptor activation R-HSA-977443 9.750570e-01 0.011 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.750570e-01 0.011 1 1
Transport to the Golgi and subsequent modification R-HSA-948021 9.752219e-01 0.011 0 0
tRNA processing R-HSA-72306 9.755356e-01 0.011 0 0
PPARA activates gene expression R-HSA-1989781 9.760763e-01 0.011 0 0
Glycogen synthesis R-HSA-3322077 9.768242e-01 0.010 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.768242e-01 0.010 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.768242e-01 0.010 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.768242e-01 0.010 0 0
Pregnenolone biosynthesis R-HSA-196108 9.768242e-01 0.010 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.778120e-01 0.010 0 0
Translation of Structural Proteins R-HSA-9683701 9.778120e-01 0.010 0 0
DAG1 glycosylations R-HSA-8931838 9.780239e-01 0.010 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.790234e-01 0.009 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.800665e-01 0.009 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.800665e-01 0.009 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.800665e-01 0.009 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.800665e-01 0.009 0 0
Abacavir metabolism R-HSA-2161541 9.800665e-01 0.009 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.800665e-01 0.009 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.800665e-01 0.009 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.800665e-01 0.009 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.800850e-01 0.009 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.802358e-01 0.009 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.803492e-01 0.009 0 0
Neddylation R-HSA-8951664 9.803689e-01 0.009 0 0
Recycling of bile acids and salts R-HSA-159418 9.806762e-01 0.008 0 0
Nucleotide biosynthesis R-HSA-8956320 9.814532e-01 0.008 0 0
CS-GAG biosynthesis R-HSA-2022870 9.828553e-01 0.008 0 0
Assembly Of The HIV Virion R-HSA-175474 9.828553e-01 0.008 0 0
Serine metabolism R-HSA-977347 9.828553e-01 0.008 0 0
Glutathione synthesis and recycling R-HSA-174403 9.828553e-01 0.008 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.828553e-01 0.008 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.830167e-01 0.007 0 0
Heme degradation R-HSA-189483 9.830167e-01 0.007 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.841022e-01 0.007 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.850807e-01 0.007 0 0
eNOS activation R-HSA-203615 9.850807e-01 0.007 0 0
Hyaluronan metabolism R-HSA-2142845 9.850807e-01 0.007 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.850807e-01 0.007 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.852542e-01 0.006 0 0
Iron uptake and transport R-HSA-917937 9.852554e-01 0.006 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.865994e-01 0.006 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.868998e-01 0.006 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.873175e-01 0.006 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.873175e-01 0.006 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.873175e-01 0.006 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.873175e-01 0.006 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.873175e-01 0.006 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.876301e-01 0.005 0 0
Synthesis of PA R-HSA-1483166 9.879893e-01 0.005 0 0
Triglyceride catabolism R-HSA-163560 9.885020e-01 0.005 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.885020e-01 0.005 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.885020e-01 0.005 0 0
Phospholipid metabolism R-HSA-1483257 9.890039e-01 0.005 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.890922e-01 0.005 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.890922e-01 0.005 0 0
Pyruvate metabolism R-HSA-70268 9.893545e-01 0.005 1 0
rRNA processing R-HSA-72312 9.898015e-01 0.004 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.899125e-01 0.004 0 0
Metabolism of folate and pterines R-HSA-196757 9.899125e-01 0.004 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.900277e-01 0.004 0 0
Extension of Telomeres R-HSA-180786 9.903678e-01 0.004 0 0
Hyaluronan degradation R-HSA-2160916 9.906186e-01 0.004 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.906186e-01 0.004 0 0
Retinoid cycle disease events R-HSA-2453864 9.906186e-01 0.004 0 0
Diseases of the neuronal system R-HSA-9675143 9.906186e-01 0.004 0 0
Diseases associated with visual transduction R-HSA-2474795 9.906186e-01 0.004 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.906186e-01 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.909895e-01 0.004 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.913450e-01 0.004 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.918872e-01 0.004 0 0
ECM proteoglycans R-HSA-3000178 9.918872e-01 0.004 0 0
Sphingolipid catabolism R-HSA-9845614 9.919316e-01 0.004 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.919316e-01 0.004 0 0
Nucleotide salvage R-HSA-8956321 9.922917e-01 0.003 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.923240e-01 0.003 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.925268e-01 0.003 0 0
Triglyceride biosynthesis R-HSA-75109 9.930608e-01 0.003 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.930608e-01 0.003 0 0
Synthesis of PE R-HSA-1483213 9.930608e-01 0.003 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.930608e-01 0.003 0 0
The phototransduction cascade R-HSA-2514856 9.931954e-01 0.003 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.932039e-01 0.003 0 0
Telomere Extension By Telomerase R-HSA-171319 9.940320e-01 0.003 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.940320e-01 0.003 0 0
Maturation of spike protein R-HSA-9694548 9.940466e-01 0.003 0 0
Selenocysteine synthesis R-HSA-2408557 9.941730e-01 0.003 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.941914e-01 0.003 0 0
Cellular response to starvation R-HSA-9711097 9.942217e-01 0.003 0 0
SLC transporter disorders R-HSA-5619102 9.943296e-01 0.002 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.946601e-01 0.002 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.947866e-01 0.002 0 0
HIV Transcription Initiation R-HSA-167161 9.947866e-01 0.002 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.947866e-01 0.002 0 0
Heme biosynthesis R-HSA-189451 9.947866e-01 0.002 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.947866e-01 0.002 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.948674e-01 0.002 0 0
Translation R-HSA-72766 9.954613e-01 0.002 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.955275e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9694635 9.957233e-01 0.002 0 0
Eukaryotic Translation Termination R-HSA-72764 9.959481e-01 0.002 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.960060e-01 0.002 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.960806e-01 0.002 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.960958e-01 0.002 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.962038e-01 0.002 0 0
Amine ligand-binding receptors R-HSA-375280 9.965058e-01 0.002 0 0
Methylation R-HSA-156581 9.965058e-01 0.002 0 0
Transcription of the HIV genome R-HSA-167172 9.965199e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.967283e-01 0.001 0 0
HS-GAG degradation R-HSA-2024096 9.967353e-01 0.001 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.969440e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.969440e-01 0.001 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.971923e-01 0.001 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.971923e-01 0.001 0 0
Triglyceride metabolism R-HSA-8979227 9.974451e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.974451e-01 0.001 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.974451e-01 0.001 0 0
CS/DS degradation R-HSA-2024101 9.975854e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.977436e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.977436e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.978582e-01 0.001 0 0
RA biosynthesis pathway R-HSA-5365859 9.979235e-01 0.001 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.979235e-01 0.001 0 0
Viral mRNA Translation R-HSA-192823 9.981895e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.982143e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.982169e-01 0.001 0 0
HS-GAG biosynthesis R-HSA-2022928 9.984644e-01 0.001 0 0
Glycosphingolipid transport R-HSA-9845576 9.984644e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.986319e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.986402e-01 0.001 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.986794e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.986794e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.986794e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.986794e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.987194e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.988422e-01 0.001 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.988644e-01 0.000 0 0
Purine salvage R-HSA-74217 9.988644e-01 0.000 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.988644e-01 0.000 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.989369e-01 0.000 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.990234e-01 0.000 0 0
RAS processing R-HSA-9648002 9.990234e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.990633e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.990735e-01 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 9.990970e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.990970e-01 0.000 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.991602e-01 0.000 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.991602e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.992113e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.993592e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.993603e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.993790e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.993933e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.994371e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.994371e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.994660e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.996357e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.996406e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.996539e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.996539e-01 0.000 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.996605e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.996605e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.996888e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.996888e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.996987e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997219e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.997374e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.997469e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.997490e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.998144e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.998491e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.998521e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998922e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.998955e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999135e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999248e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.999250e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999355e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999393e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999451e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999506e-01 0.000 0 0
Disease R-HSA-1643685 9.999543e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999587e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999590e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999621e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999648e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.999786e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999787e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999797e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999857e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999876e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999878e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999890e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999895e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.999895e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999909e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999916e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999933e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999944e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999949e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999951e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999957e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999958e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999971e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999977e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999977e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999978e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999980e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999985e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999990e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999991e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999995e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999996e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999996e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999997e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999998e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999999e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999999e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999999e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 1 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 1 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Antimicrobial peptides R-HSA-6803157 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Initial triggering of complement R-HSA-166663 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways