PKACG

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A6ND36 S610 Sugiyama FAM83G PAWS1 LSDQDSHSGSSGRGPGPRRPsVAssVsEEyFEVREHSVPLR
O60841 S107 Sugiyama EIF5B IF2 KIAA0741 NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O94763 S372 Sugiyama URI1 C19orf2 NNX3 PPP1R19 RMP URI KNTTLKFSEKKEEAKRKRKNstGsGHsAQELPTIRTPADIY
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P09923 S111 Sugiyama ALPI DRFPYLALSKTYNVDRQVPDsAATATAYLCGVKANFQTIGL
P10412 S36 Sugiyama H1-4 H1F4 HIST1H1E EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P16402 S37 Sugiyama H1-3 H1F3 HIST1H1D KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16403 S36 Sugiyama H1-2 H1F2 HIST1H1C EKAPVKKKAAKKAGGtPRKAsGPPVsELItKAVAASKERsG
P17612 S213 Sugiyama PRKACA PKACA KGRtWtLCGtPEYLAPEIILsKGYNKAVDWWALGVLIYEMA
P17612 T196 Sugiyama PRKACA PKACA DQQGYIQVTDFGFAKRVKGRtWtLCGtPEYLAPEIILsKGY
P17612 T198 Sugiyama PRKACA PKACA QGYIQVTDFGFAKRVKGRtWtLCGtPEYLAPEIILsKGYNK
P17612 T202 Sugiyama PRKACA PKACA QVTDFGFAKRVKGRtWtLCGtPEYLAPEIILsKGYNKAVDW
P22059 S190 Sugiyama OSBP OSBP1 QRWVTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNT
P22059 S193 Sugiyama OSBP OSBP1 VTALELAKAKAVKMLAEsDEsGDEEsVsQtDKTELQNTLRT
P22612 S15 Sugiyama PRKACG ______MGNAPAKKDtEQEEsVNEFLAKARGDFLYRWGNPA
P22612 S213 Sugiyama PRKACG KGRtWtLCGtPEYLAPEIILsKGYNKAVDWWALGVLIYEMA
P22612 S40 Sugiyama PRKACG LAKARGDFLYRWGNPAQNTAssDQFERLRtLGMGsFGRVML
P22612 S41 Sugiyama PRKACG AKARGDFLYRWGNPAQNTAssDQFERLRtLGMGsFGRVMLV
P22612 S54 Sugiyama PRKACG PAQNTAssDQFERLRtLGMGsFGRVMLVRHQETGGHYAMKI
P22612 T10 Sugiyama PRKACG ___________MGNAPAKKDtEQEEsVNEFLAKARGDFLYR
P22612 T196 Sugiyama PRKACG DQQGYLQVTDFGFAKRVKGRtWtLCGtPEYLAPEIILsKGY
P22612 T198 Sugiyama PRKACG QGYLQVTDFGFAKRVKGRtWtLCGtPEYLAPEIILsKGYNK
P22612 T202 Sugiyama PRKACG QVTDFGFAKRVKGRtWtLCGtPEYLAPEIILsKGYNKAVDW
P22612 T49 Sugiyama PRKACG YRWGNPAQNTAssDQFERLRtLGMGsFGRVMLVRHQETGGH
P22694 S213 Sugiyama PRKACB KGRtWtLCGtPEYLAPEIILsKGYNKAVDWWALGVLIYEMA
P22694 T196 Sugiyama PRKACB DHQGYIQVTDFGFAKRVKGRtWtLCGtPEYLAPEIILsKGY
P22694 T198 Sugiyama PRKACB QGYIQVTDFGFAKRVKGRtWtLCGtPEYLAPEIILsKGYNK
P22694 T202 Sugiyama PRKACB QVTDFGFAKRVKGRtWtLCGtPEYLAPEIILsKGYNKAVDW
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P29474 S1177 SIGNOR NOS3 EDIFGLTLRTQEVTSRIRtQsFsLQERQLRGAVPWAFDPPG
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P47712 S724 Sugiyama PLA2G4A CPLA2 PLA2G4 NIDVIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFL
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q09161 S22 Sugiyama NCBP1 CBP80 NCBP SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q13247 S297 Sugiyama SRSF6 SFRS6 SRP55 RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q14671 S709 Sugiyama PUM1 KIAA0099 PUMH1 LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14896 S275 SIGNOR MYBPC3 TVHEAMGTGDLDLLSAFRRTsLAGGGRRIsDSHEDTGILDF
Q14896 S284 SIGNOR MYBPC3 DLDLLSAFRRTsLAGGGRRIsDSHEDTGILDFSSLLKKRDs
Q14896 S304 SIGNOR MYBPC3 sDSHEDTGILDFSSLLKKRDsFRTPRDsKLEAPAEEDVWEI
Q14896 S311 SIGNOR MYBPC3 GILDFSSLLKKRDsFRTPRDsKLEAPAEEDVWEILRQAPPS
Q14978 S686 Sugiyama NOLC1 KIAA0035 NS5ATP13 KGKSFRHEKTKKKRGsYRGGsIsVQVNsIKFDsE_______
Q6GYQ0 S860 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 DEFIAERLRSGNASTMTRRGssPGsLEIPKDLPDILNKQNQ
Q6PIY7 S116 SIGNOR TENT2 GLD2 PAPD4 PHQEPtVVNQIVPLsGERRYsMPPLFHTHYVPDIVRCVPPF
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86WG5 T1434 Sugiyama SBF2 CMT4B2 KIAA1766 MTMR13 WDITAQVTSLVQLLSDPFYRtLEGFQMLVEKEWLSFGHKFS
Q8IZ21 S590 Sugiyama PHACTR4 PRO2963 SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q92766 S1167 Sugiyama RREB1 FINB AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q92934 S118 SIGNOR BAD BBC6 BCL2L8 RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934 S75 SIGNOR BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934 S99 SIGNOR BAD BBC6 BCL2L8 GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q9BX95 S112 Sugiyama SGPP1 SPP1 GLAAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLF
Q9BX95 T114 Sugiyama SGPP1 SPP1 AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9C0C2 S429 Sugiyama TNKS1BP1 KIAA1741 TAB182 EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin modifying enzymes R-HSA-3247509 7.493674e-08 7.125 0 0
NRAGE signals death through JNK R-HSA-193648 7.335871e-08 7.135 0 0
G alpha (12/13) signalling events R-HSA-416482 1.947257e-07 6.711 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.830897e-07 6.737 0 0
Chromatin organization R-HSA-4839726 2.406320e-07 6.619 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.814731e-07 6.317 0 0
Signal Transduction R-HSA-162582 2.218063e-06 5.654 1 0
Cell Cycle R-HSA-1640170 3.052141e-06 5.515 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.961619e-06 5.304 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 9.493840e-06 5.023 0 0
Death Receptor Signaling R-HSA-73887 8.823021e-06 5.054 0 0
Cell Cycle Checkpoints R-HSA-69620 1.086558e-05 4.964 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.952153e-05 4.403 0 0
Signaling by ROBO receptors R-HSA-376176 4.440439e-05 4.353 1 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.620477e-05 4.335 0 0
Axon guidance R-HSA-422475 1.122115e-04 3.950 1 0
Rap1 signalling R-HSA-392517 1.472439e-04 3.832 1 1
PKMTs methylate histone lysines R-HSA-3214841 2.112585e-04 3.675 0 0
Cell Cycle, Mitotic R-HSA-69278 2.532200e-04 3.597 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.165400e-04 3.500 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.675749e-04 3.435 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.675749e-04 3.435 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.949648e-04 3.403 0 0
Nervous system development R-HSA-9675108 4.106537e-04 3.387 1 0
Mitotic Spindle Checkpoint R-HSA-69618 7.549339e-04 3.122 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.144851e-03 2.941 0 0
HDMs demethylate histones R-HSA-3214842 1.197630e-03 2.922 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.201101e-03 2.920 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.164550e-03 2.934 1 0
Regulation of TP53 Activity R-HSA-5633007 1.187063e-03 2.926 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.977532e-03 2.704 1 1
RET signaling R-HSA-8853659 1.868099e-03 2.729 1 1
Calmodulin induced events R-HSA-111933 1.868099e-03 2.729 1 0
CaM pathway R-HSA-111997 1.868099e-03 2.729 1 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.977532e-03 2.704 0 0
Apoptotic execution phase R-HSA-75153 1.970900e-03 2.705 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.943739e-03 2.711 0 0
Activation of RAC1 R-HSA-428540 2.063753e-03 2.685 0 0
Cellular Senescence R-HSA-2559583 2.354206e-03 2.628 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.403974e-03 2.619 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.452232e-03 2.610 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.761235e-03 2.559 0 0
HATs acetylate histones R-HSA-3214847 2.892021e-03 2.539 0 0
DARPP-32 events R-HSA-180024 3.024699e-03 2.519 1 1
Epigenetic regulation of gene expression R-HSA-212165 3.263227e-03 2.486 0 0
RAF activation R-HSA-5673000 3.533869e-03 2.452 0 0
Mitotic Prometaphase R-HSA-68877 3.851104e-03 2.414 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.076202e-03 2.390 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 4.279152e-03 2.369 0 0
Gene expression (Transcription) R-HSA-74160 4.506281e-03 2.346 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.729225e-03 2.325 0 0
Post NMDA receptor activation events R-HSA-438064 4.935404e-03 2.307 1 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.535850e-03 2.257 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.535850e-03 2.257 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 5.508753e-03 2.259 0 0
mRNA Splicing R-HSA-72172 5.587835e-03 2.253 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.978291e-03 2.223 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.366910e-03 2.196 0 0
Ca-dependent events R-HSA-111996 6.453463e-03 2.190 1 0
Regulation of PTEN localization R-HSA-8948747 6.601559e-03 2.180 0 0
Kinesins R-HSA-983189 6.846161e-03 2.165 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 7.308857e-03 2.136 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 7.259191e-03 2.139 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.614533e-03 2.118 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.837372e-03 2.106 1 1
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.435326e-03 2.074 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.473062e-03 2.072 0 0
Signaling by GSK3beta mutants R-HSA-5339716 8.670206e-03 2.062 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 8.844232e-03 2.053 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 9.375632e-03 2.028 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 9.375632e-03 2.028 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 9.440049e-03 2.025 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 9.688294e-03 2.014 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.161206e-02 1.935 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.161206e-02 1.935 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.161206e-02 1.935 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.161206e-02 1.935 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.161206e-02 1.935 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.165167e-02 1.934 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.165167e-02 1.934 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.165167e-02 1.934 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.021369e-02 1.991 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.160216e-02 1.935 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.160216e-02 1.935 0 0
FOXO-mediated transcription R-HSA-9614085 1.082723e-02 1.965 0 0
Signaling by RAS mutants R-HSA-6802949 1.165167e-02 1.934 0 0
DAG and IP3 signaling R-HSA-1489509 1.012188e-02 1.995 1 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.097152e-02 1.960 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.050931e-02 1.978 0 0
mRNA 3'-end processing R-HSA-72187 1.165269e-02 1.934 0 0
Neurexins and neuroligins R-HSA-6794361 1.165269e-02 1.934 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.183336e-02 1.927 0 0
Signaling by NTRKs R-HSA-166520 1.274159e-02 1.895 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.295049e-02 1.888 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.327043e-02 1.877 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.455324e-02 1.837 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.421788e-02 1.847 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.391634e-02 1.856 0 0
Unwinding of DNA R-HSA-176974 1.364477e-02 1.865 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.462754e-02 1.835 1 1
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.462754e-02 1.835 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.611420e-02 1.793 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.506431e-02 1.822 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.526127e-02 1.816 0 0
M Phase R-HSA-68886 1.605200e-02 1.794 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 1.519518e-02 1.818 1 1
MTOR signalling R-HSA-165159 1.527997e-02 1.816 0 0
NGF-stimulated transcription R-HSA-9031628 1.524236e-02 1.817 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.647031e-02 1.783 0 0
PLC beta mediated events R-HSA-112043 1.647031e-02 1.783 1 0
G2/M Checkpoints R-HSA-69481 1.672311e-02 1.777 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.692174e-02 1.772 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.702035e-02 1.769 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.702035e-02 1.769 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.744241e-02 1.758 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.844083e-02 1.734 0 0
MAPK family signaling cascades R-HSA-5683057 1.722958e-02 1.764 1 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.856495e-02 1.731 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.947996e-02 1.710 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.287755e-02 1.641 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.287755e-02 1.641 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.287755e-02 1.641 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.287755e-02 1.641 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.287755e-02 1.641 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.256155e-02 1.647 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.398642e-02 1.620 0 0
Signaling by APC mutants R-HSA-4839744 2.452891e-02 1.610 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.452891e-02 1.610 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.452891e-02 1.610 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.452891e-02 1.610 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.623027e-02 1.581 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.537870e-02 1.596 1 0
Cell-extracellular matrix interactions R-HSA-446353 2.452085e-02 1.610 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.522872e-02 1.598 0 0
Neurodegenerative Diseases R-HSA-8863678 2.522872e-02 1.598 0 0
FLT3 Signaling R-HSA-9607240 2.625420e-02 1.581 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.522872e-02 1.598 1 1
MITF-M-regulated melanocyte development R-HSA-9730414 2.421413e-02 1.616 0 0
Interleukin-37 signaling R-HSA-9008059 2.623027e-02 1.581 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.649268e-02 1.577 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.668602e-02 1.574 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.681602e-02 1.572 0 0
Meiotic synapsis R-HSA-1221632 2.787104e-02 1.555 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.798166e-02 1.553 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.934440e-02 1.532 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.901850e-02 1.537 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.975939e-02 1.526 0 0
G-protein mediated events R-HSA-112040 3.109113e-02 1.507 1 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.036523e-02 1.518 1 1
Opioid Signalling R-HSA-111885 2.977015e-02 1.526 1 0
Negative regulation of MAPK pathway R-HSA-5675221 2.980280e-02 1.526 0 0
RNA Polymerase II Transcription R-HSA-73857 2.915040e-02 1.535 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.160108e-02 1.500 0 0
Signaling by AXIN mutants R-HSA-4839735 3.160108e-02 1.500 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.036523e-02 1.518 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.277532e-02 1.484 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.310181e-02 1.480 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 3.322615e-02 1.479 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 3.322615e-02 1.479 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.346461e-02 1.475 1 1
Negative regulation of the PI3K/AKT network R-HSA-199418 3.439183e-02 1.464 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.459879e-02 1.461 0 0
TRP channels R-HSA-3295583 3.481996e-02 1.458 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.506438e-02 1.455 0 0
Centrosome maturation R-HSA-380287 3.530802e-02 1.452 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.695729e-02 1.432 1 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.695301e-02 1.432 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.961913e-02 1.402 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.982927e-02 1.400 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.001266e-02 1.398 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.001266e-02 1.398 0 0
Semaphorin interactions R-HSA-373755 4.001266e-02 1.398 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.009300e-02 1.397 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.016861e-02 1.396 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.043265e-02 1.393 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.247507e-02 1.372 0 0
Netrin-1 signaling R-HSA-373752 4.248202e-02 1.372 0 0
Mitotic Prophase R-HSA-68875 4.271138e-02 1.369 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.322944e-02 1.364 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.329607e-02 1.364 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 4.775481e-02 1.321 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.855810e-02 1.314 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.855810e-02 1.314 0 0
Striated Muscle Contraction R-HSA-390522 4.575323e-02 1.340 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.683545e-02 1.329 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.507249e-02 1.346 0 0
Frs2-mediated activation R-HSA-170968 4.924427e-02 1.308 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 4.924427e-02 1.308 0 0
Signaling by Hippo R-HSA-2028269 4.461423e-02 1.351 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.855810e-02 1.314 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.916740e-02 1.308 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.940751e-02 1.306 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 5.183217e-02 1.285 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.196977e-02 1.284 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.201817e-02 1.284 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.201817e-02 1.284 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.271010e-02 1.278 0 0
PKA activation R-HSA-163615 5.307215e-02 1.275 1 1
PKA activation in glucagon signalling R-HSA-164378 5.307215e-02 1.275 1 1
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.307215e-02 1.275 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.307215e-02 1.275 0 0
Polo-like kinase mediated events R-HSA-156711 5.307215e-02 1.275 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.403151e-02 1.267 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.492724e-02 1.260 0 0
Regulation of KIT signaling R-HSA-1433559 5.986003e-02 1.223 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.075733e-02 1.216 0 0
Activation of the pre-replicative complex R-HSA-68962 6.075733e-02 1.216 0 0
ESR-mediated signaling R-HSA-8939211 5.572484e-02 1.254 0 0
MAP2K and MAPK activation R-HSA-5674135 6.202670e-02 1.207 0 0
Peptide chain elongation R-HSA-156902 6.294099e-02 1.201 0 0
DNA Double Strand Break Response R-HSA-5693606 5.749653e-02 1.240 0 0
G2/M Transition R-HSA-69275 5.764839e-02 1.239 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.646571e-02 1.248 0 0
Diseases of programmed cell death R-HSA-9645723 6.294099e-02 1.201 0 0
Signaling by ERBB4 R-HSA-1236394 5.812131e-02 1.236 0 0
Generic Transcription Pathway R-HSA-212436 6.164137e-02 1.210 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.366611e-02 1.196 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.464586e-02 1.189 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.472669e-02 1.189 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.566386e-02 1.183 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.566386e-02 1.183 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 6.566386e-02 1.183 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.674563e-02 1.176 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 6.674563e-02 1.176 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.674563e-02 1.176 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.992441e-02 1.155 0 0
Muscle contraction R-HSA-397014 7.098022e-02 1.149 0 0
Tight junction interactions R-HSA-420029 7.134241e-02 1.147 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.134241e-02 1.147 0 0
Long-term potentiation R-HSA-9620244 7.134241e-02 1.147 0 0
Formation of the nephric duct R-HSA-9830364 7.134241e-02 1.147 0 0
DCC mediated attractive signaling R-HSA-418885 7.167425e-02 1.145 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 7.167425e-02 1.145 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.167425e-02 1.145 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 7.167425e-02 1.145 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.198697e-02 1.143 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.882307e-02 1.103 0 0
Potassium transport channels R-HSA-1296067 7.882307e-02 1.103 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.466931e-02 1.072 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.272096e-02 1.138 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.779008e-02 1.109 0 0
Signaling by SCF-KIT R-HSA-1433557 7.608716e-02 1.119 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.098083e-02 1.092 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.244839e-02 1.084 0 0
Separation of Sister Chromatids R-HSA-2467813 8.173069e-02 1.088 0 0
Prolonged ERK activation events R-HSA-169893 8.466931e-02 1.072 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.109940e-02 1.091 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.244839e-02 1.084 0 0
Signaling by WNT in cancer R-HSA-4791275 7.732504e-02 1.112 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 8.063813e-02 1.093 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 8.652863e-02 1.063 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 8.652863e-02 1.063 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.887487e-02 1.051 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 9.198018e-02 1.036 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.090330e-01 0.962 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.090330e-01 0.962 0 0
KIT mutants bind TKIs R-HSA-9669921 1.090330e-01 0.962 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.090330e-01 0.962 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.090330e-01 0.962 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.090330e-01 0.962 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.090330e-01 0.962 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.090330e-01 0.962 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.090330e-01 0.962 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.090330e-01 0.962 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.090330e-01 0.962 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.090330e-01 0.962 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.090330e-01 0.962 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.090330e-01 0.962 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.090330e-01 0.962 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.090330e-01 0.962 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.090330e-01 0.962 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.107315e-01 0.956 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.107315e-01 0.956 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.107315e-01 0.956 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.107315e-01 0.956 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.107315e-01 0.956 0 0
SOS-mediated signalling R-HSA-112412 1.107315e-01 0.956 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 9.789254e-02 1.009 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 9.789254e-02 1.009 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.599848e-02 1.018 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 9.634301e-02 1.016 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.915066e-02 1.004 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.006155e-01 0.997 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.300235e-02 1.032 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.011307e-01 0.995 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.009617e-01 0.996 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.073131e-01 0.969 0 0
Signaling by PDGFR in disease R-HSA-9671555 9.599848e-02 1.018 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.047490e-01 0.980 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.067618e-01 0.972 0 0
DNA Double-Strand Break Repair R-HSA-5693532 9.983937e-02 1.001 0 0
Homology Directed Repair R-HSA-5693538 9.246321e-02 1.034 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.078770e-01 0.967 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 9.789254e-02 1.009 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 9.599848e-02 1.018 0 0
mTORC1-mediated signalling R-HSA-166208 1.089608e-01 0.963 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.025593e-01 0.989 0 0
Signaling by ALK in cancer R-HSA-9700206 1.025593e-01 0.989 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.112612e-01 0.954 0 0
Eukaryotic Translation Termination R-HSA-72764 1.139441e-01 0.943 0 0
Specification of primordial germ cells R-HSA-9827857 1.140625e-01 0.943 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.144380e-01 0.941 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.144380e-01 0.941 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.061835e-01 0.686 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.061835e-01 0.686 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.061835e-01 0.686 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.061835e-01 0.686 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.532398e-01 0.815 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.532398e-01 0.815 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.532398e-01 0.815 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.532398e-01 0.815 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 2.927459e-01 0.534 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.927459e-01 0.534 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.927459e-01 0.534 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.927459e-01 0.534 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.927459e-01 0.534 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 2.927459e-01 0.534 0 0
Intestinal infectious diseases R-HSA-8942233 2.927459e-01 0.534 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 2.927459e-01 0.534 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.927459e-01 0.534 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 2.927459e-01 0.534 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 2.927459e-01 0.534 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.927459e-01 0.534 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.927459e-01 0.534 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.927459e-01 0.534 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.927459e-01 0.534 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.927459e-01 0.534 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.927459e-01 0.534 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 2.927459e-01 0.534 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.927459e-01 0.534 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 1.941111e-01 0.712 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.941111e-01 0.712 0 0
IRS activation R-HSA-74713 1.941111e-01 0.712 0 0
Type I hemidesmosome assembly R-HSA-446107 1.359536e-01 0.867 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.359536e-01 0.867 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.361399e-01 0.627 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.361399e-01 0.627 0 0
Signaling by MAPK mutants R-HSA-9652817 2.361399e-01 0.627 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.698735e-01 0.432 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.698735e-01 0.432 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.698735e-01 0.432 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.698735e-01 0.432 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.698735e-01 0.432 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.698735e-01 0.432 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.698735e-01 0.432 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.698735e-01 0.432 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.698735e-01 0.432 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.698735e-01 0.432 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.698735e-01 0.432 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.698735e-01 0.432 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.698735e-01 0.432 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.698735e-01 0.432 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.698735e-01 0.432 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.698735e-01 0.432 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.698735e-01 0.432 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.698735e-01 0.432 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.698735e-01 0.432 0 0
Formation of axial mesoderm R-HSA-9796292 1.360865e-01 0.866 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.360865e-01 0.866 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.360865e-01 0.866 0 0
Formation of apoptosome R-HSA-111458 1.912974e-01 0.718 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.912974e-01 0.718 0 0
PI3K/AKT activation R-HSA-198203 1.912974e-01 0.718 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.912974e-01 0.718 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.785885e-01 0.555 0 0
CREB phosphorylation R-HSA-199920 2.785885e-01 0.555 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.785885e-01 0.555 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.785885e-01 0.555 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.785885e-01 0.555 0 0
Ephrin signaling R-HSA-3928664 1.303607e-01 0.885 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.792662e-01 0.747 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.792662e-01 0.747 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.476431e-01 0.831 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.476431e-01 0.831 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.658366e-01 0.780 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.658366e-01 0.780 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.658366e-01 0.780 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.658366e-01 0.780 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.658366e-01 0.780 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.658366e-01 0.780 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.023745e-01 0.694 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.511248e-01 0.600 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.511248e-01 0.600 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.208659e-01 0.494 0 0
Netrin mediated repulsion signals R-HSA-418886 3.208659e-01 0.494 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.208659e-01 0.494 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.208659e-01 0.494 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.208659e-01 0.494 0 0
Axonal growth stimulation R-HSA-209563 4.385942e-01 0.358 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.385942e-01 0.358 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.385942e-01 0.358 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.385942e-01 0.358 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.385942e-01 0.358 0 0
Invadopodia formation R-HSA-8941237 4.385942e-01 0.358 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.273215e-01 0.895 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.527841e-01 0.816 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.527841e-01 0.816 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.848620e-01 0.733 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.262988e-01 0.645 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.262988e-01 0.645 0 0
Trafficking of AMPA receptors R-HSA-399719 1.405927e-01 0.852 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.689013e-01 0.772 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.820038e-01 0.550 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.293694e-01 0.888 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.856922e-01 0.731 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.856922e-01 0.731 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.856922e-01 0.731 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.508913e-01 0.601 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.625050e-01 0.441 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.625050e-01 0.441 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.625050e-01 0.441 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.690149e-01 0.772 0 0
Notch-HLH transcription pathway R-HSA-350054 2.250681e-01 0.648 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.031024e-01 0.692 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.031024e-01 0.692 0 0
HIV elongation arrest and recovery R-HSA-167287 2.031024e-01 0.692 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.031024e-01 0.692 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.131838e-01 0.504 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.131838e-01 0.504 0 0
HDACs deacetylate histones R-HSA-3214815 1.186018e-01 0.926 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.674575e-01 0.776 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.674575e-01 0.776 0 0
DNA methylation R-HSA-5334118 2.210743e-01 0.655 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.210743e-01 0.655 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.997166e-01 0.700 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.997166e-01 0.700 0 0
HIV Transcription Elongation R-HSA-167169 1.811805e-01 0.742 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.811805e-01 0.742 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.811805e-01 0.742 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 1.811805e-01 0.742 0 0
Nucleosome assembly R-HSA-774815 1.649093e-01 0.783 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.649093e-01 0.783 0 0
HSF1-dependent transactivation R-HSA-3371571 1.505029e-01 0.822 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.157921e-01 0.936 0 0
E2F mediated regulation of DNA replication R-HSA-113510 3.015049e-01 0.521 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.015049e-01 0.521 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.444366e-01 0.463 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.444366e-01 0.463 0 0
WNT mediated activation of DVL R-HSA-201688 4.031426e-01 0.395 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.031426e-01 0.395 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.998239e-01 0.301 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.998239e-01 0.301 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.998239e-01 0.301 0 0
ATP sensitive Potassium channels R-HSA-1296025 4.998239e-01 0.301 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.998239e-01 0.301 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.998239e-01 0.301 0 0
snRNP Assembly R-HSA-191859 1.582509e-01 0.801 0 0
Metabolism of non-coding RNA R-HSA-194441 1.582509e-01 0.801 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.323858e-01 0.634 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.894300e-01 0.538 0 0
Erythropoietin activates RAS R-HSA-9027284 3.755579e-01 0.425 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.755579e-01 0.425 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.755579e-01 0.425 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 3.755579e-01 0.425 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.601043e-01 0.796 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.425020e-01 0.354 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.425020e-01 0.354 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.425020e-01 0.354 0 0
Interaction between L1 and Ankyrins R-HSA-445095 3.339969e-01 0.476 0 0
Packaging Of Telomere Ends R-HSA-171306 3.339969e-01 0.476 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.538337e-01 0.813 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 4.063672e-01 0.391 0 0
Differentiation of T cells R-HSA-9945266 4.063672e-01 0.391 0 0
Phosphorylation of the APC/C R-HSA-176412 4.063672e-01 0.391 0 0
Viral mRNA Translation R-HSA-192823 1.755150e-01 0.756 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.022292e-01 0.520 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.789827e-01 0.421 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.565194e-01 0.448 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 3.372822e-01 0.472 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.047394e-01 0.393 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.367071e-01 0.360 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.367071e-01 0.360 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.367071e-01 0.360 0 0
Phase 2 - plateau phase R-HSA-5576893 4.367071e-01 0.360 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.803789e-01 0.318 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.543788e-01 0.256 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.543788e-01 0.256 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.543788e-01 0.256 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 5.543788e-01 0.256 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.543788e-01 0.256 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.543788e-01 0.256 0 0
Defective F9 activation R-HSA-9673221 5.543788e-01 0.256 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.016431e-01 0.396 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 4.016431e-01 0.396 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.302851e-01 0.366 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.240968e-01 0.373 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.240968e-01 0.373 0 0
Orc1 removal from chromatin R-HSA-68949 3.903391e-01 0.409 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.903391e-01 0.409 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.555278e-01 0.341 0 0
Deadenylation of mRNA R-HSA-429947 4.555278e-01 0.341 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.166285e-01 0.287 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.166285e-01 0.287 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.166285e-01 0.287 0 0
ERKs are inactivated R-HSA-202670 5.166285e-01 0.287 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.291462e-01 0.483 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.865100e-01 0.413 0 0
Transcription of the HIV genome R-HSA-167172 3.827425e-01 0.417 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.463877e-01 0.350 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.954590e-01 0.305 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.954590e-01 0.305 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.954590e-01 0.305 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.312888e-01 0.365 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.684539e-01 0.329 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.349265e-01 0.362 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.224364e-01 0.374 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.782892e-01 0.320 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.236623e-01 0.281 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.511553e-01 0.259 0 0
Leading Strand Synthesis R-HSA-69109 5.511553e-01 0.259 0 0
Polymerase switching R-HSA-69091 5.511553e-01 0.259 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.511553e-01 0.259 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.511553e-01 0.259 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.979126e-01 0.303 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.979126e-01 0.303 1 1
RNA Polymerase I Transcription Termination R-HSA-73863 5.286596e-01 0.277 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.286596e-01 0.277 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.172753e-01 0.286 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.327627e-01 0.273 0 0
Telomere Extension By Telomerase R-HSA-171319 5.519576e-01 0.258 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.519576e-01 0.258 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.568364e-01 0.254 0 0
Signaling by Erythropoietin R-HSA-9006335 5.746308e-01 0.241 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.746308e-01 0.241 0 0
RNA Polymerase III Transcription R-HSA-74158 2.323858e-01 0.634 0 0
Integrin signaling R-HSA-354192 1.690149e-01 0.772 0 0
Regulation of necroptotic cell death R-HSA-5675482 4.684539e-01 0.329 0 0
EPH-Ephrin signaling R-HSA-2682334 2.945804e-01 0.531 0 0
Downstream signal transduction R-HSA-186763 1.405927e-01 0.852 0 0
Formation of definitive endoderm R-HSA-9823730 1.658366e-01 0.780 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.016431e-01 0.396 0 0
Chromosome Maintenance R-HSA-73886 3.927621e-01 0.406 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.493515e-01 0.603 0 0
EGFR downregulation R-HSA-182971 4.240968e-01 0.373 0 0
Adipogenesis R-HSA-9843745 4.331052e-01 0.363 0 0
Signaling by EGFR R-HSA-177929 2.106114e-01 0.677 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.509757e-01 0.259 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.303607e-01 0.885 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.815116e-01 0.741 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.983664e-01 0.703 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.983664e-01 0.703 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.163000e-01 0.934 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 2.262988e-01 0.645 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.165981e-01 0.933 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.722925e-01 0.565 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.511553e-01 0.259 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.562255e-01 0.591 0 0
MHC class II antigen presentation R-HSA-2132295 4.156967e-01 0.381 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 4.979126e-01 0.303 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.983664e-01 0.703 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.436717e-01 0.353 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.367071e-01 0.360 0 0
Aggrephagy R-HSA-9646399 4.584440e-01 0.339 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.452822e-01 0.263 0 0
Circadian clock R-HSA-9909396 5.409783e-01 0.267 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.158262e-01 0.666 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.326038e-01 0.877 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.281983e-01 0.368 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.509757e-01 0.259 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.452822e-01 0.263 0 0
Signaling by ERBB2 R-HSA-1227986 3.865100e-01 0.413 0 0
p75NTR signals via NF-kB R-HSA-193639 1.792662e-01 0.747 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.106114e-01 0.677 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 4.436717e-01 0.353 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.629137e-01 0.788 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.912974e-01 0.718 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.953731e-01 0.709 0 0
Cellular response to heat stress R-HSA-3371556 3.927621e-01 0.406 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.942768e-01 0.531 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.602068e-01 0.795 0 0
GAB1 signalosome R-HSA-180292 4.954590e-01 0.305 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.326263e-01 0.274 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.208659e-01 0.494 0 0
DNA strand elongation R-HSA-69190 1.545011e-01 0.811 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.542318e-01 0.812 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.506955e-01 0.822 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.047394e-01 0.393 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.192068e-01 0.378 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.675684e-01 0.435 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.997166e-01 0.700 0 0
Apoptotic factor-mediated response R-HSA-111471 4.954590e-01 0.305 0 0
RNA Polymerase I Transcription R-HSA-73864 4.079553e-01 0.389 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.115034e-01 0.386 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.629137e-01 0.788 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.463877e-01 0.350 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.172269e-01 0.499 0 0
NF-kB is activated and signals survival R-HSA-209560 2.511248e-01 0.600 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 2.820038e-01 0.550 0 0
Adrenoceptors R-HSA-390696 3.625050e-01 0.441 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.625050e-01 0.441 0 0
cGMP effects R-HSA-418457 3.444366e-01 0.463 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.031426e-01 0.395 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.031426e-01 0.395 0 0
Regulation of gap junction activity R-HSA-191650 4.998239e-01 0.301 0 0
Meiosis R-HSA-1500620 1.268332e-01 0.897 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.973642e-01 0.527 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.232643e-01 0.651 0 0
Hedgehog 'off' state R-HSA-5610787 2.195556e-01 0.658 1 1
IRS-related events triggered by IGF1R R-HSA-2428928 4.026487e-01 0.395 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.315462e-01 0.881 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.315462e-01 0.881 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.973642e-01 0.527 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.367071e-01 0.360 0 0
S Phase R-HSA-69242 2.170578e-01 0.663 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.912974e-01 0.718 0 0
Signal attenuation R-HSA-74749 1.912974e-01 0.718 0 0
Repression of WNT target genes R-HSA-4641265 2.820038e-01 0.550 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.190948e-01 0.924 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.511553e-01 0.259 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.511553e-01 0.259 0 0
Signaling by PDGF R-HSA-186797 5.586269e-01 0.253 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.790520e-01 0.421 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.434512e-01 0.464 0 0
TNF signaling R-HSA-75893 4.590766e-01 0.338 0 0
Glycogen metabolism R-HSA-8982491 1.811805e-01 0.742 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.179699e-01 0.928 1 1
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.340651e-01 0.873 1 0
Signaling by WNT R-HSA-195721 2.094537e-01 0.679 0 0
Calcineurin activates NFAT R-HSA-2025928 1.629137e-01 0.788 0 0
HDL assembly R-HSA-8963896 1.571217e-01 0.804 1 1
Abacavir transmembrane transport R-HSA-2161517 2.785885e-01 0.555 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.373917e-01 0.862 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.625050e-01 0.441 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.625050e-01 0.441 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.625050e-01 0.441 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.015049e-01 0.521 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.172269e-01 0.499 1 0
Formation of the posterior neural plate R-HSA-9832991 4.803789e-01 0.318 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.389133e-01 0.470 0 0
Defective pyroptosis R-HSA-9710421 3.756306e-01 0.425 0 0
MET promotes cell motility R-HSA-8875878 4.182597e-01 0.379 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.166285e-01 0.287 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.127629e-01 0.384 1 1
Nuclear RNA decay R-HSA-9930044 4.684539e-01 0.329 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.684539e-01 0.329 0 0
IRS-mediated signalling R-HSA-112399 4.760791e-01 0.322 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.375834e-01 0.359 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.172753e-01 0.286 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.943753e-01 0.306 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.773389e-01 0.239 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.713624e-01 0.566 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.611394e-01 0.583 0 0
Triglyceride catabolism R-HSA-163560 3.777329e-01 0.423 1 1
IGF1R signaling cascade R-HSA-2428924 4.510129e-01 0.346 0 0
G1 Phase R-HSA-69236 5.550794e-01 0.256 0 0
Cyclin D associated events in G1 R-HSA-69231 5.550794e-01 0.256 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.543879e-01 0.343 0 0
Cellular response to starvation R-HSA-9711097 3.034988e-01 0.518 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.902388e-01 0.310 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.346756e-01 0.871 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.386469e-01 0.470 0 0
Signaling by FGFR in disease R-HSA-1226099 3.503615e-01 0.455 0 0
Autophagy R-HSA-9612973 1.604745e-01 0.795 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.386469e-01 0.470 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.172753e-01 0.286 0 0
Signaling by VEGF R-HSA-194138 1.983664e-01 0.703 1 0
Signalling to ERKs R-HSA-187687 1.177751e-01 0.929 0 0
Integration of energy metabolism R-HSA-163685 3.189556e-01 0.496 1 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 3.865100e-01 0.413 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 3.865100e-01 0.413 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 3.865100e-01 0.413 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 3.865100e-01 0.413 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.684867e-01 0.434 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.918217e-01 0.717 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.532398e-01 0.815 0 0
Leukotriene receptors R-HSA-391906 2.785885e-01 0.555 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.690149e-01 0.772 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.444366e-01 0.463 0 0
Lipophagy R-HSA-9613354 4.031426e-01 0.395 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.425020e-01 0.354 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.543788e-01 0.256 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 4.664424e-01 0.331 0 0
GPER1 signaling R-HSA-9634597 4.680664e-01 0.330 1 1
Switching of origins to a post-replicative state R-HSA-69052 4.588492e-01 0.338 0 0
Meiotic recombination R-HSA-912446 5.220253e-01 0.282 0 0
RMTs methylate histone arginines R-HSA-3214858 3.941966e-01 0.404 0 0
G1/S Transition R-HSA-69206 2.705672e-01 0.568 0 0
Ion homeostasis R-HSA-5578775 1.279361e-01 0.893 0 0
Signaling by NODAL R-HSA-1181150 5.509757e-01 0.259 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.232643e-01 0.651 1 1
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.670304e-01 0.331 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.012916e-01 0.696 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.326263e-01 0.274 0 0
Signaling by Hedgehog R-HSA-5358351 4.277738e-01 0.369 1 0
Macroautophagy R-HSA-1632852 1.576159e-01 0.802 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 2.262988e-01 0.645 0 0
PTEN Regulation R-HSA-6807070 5.326839e-01 0.274 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 5.746308e-01 0.241 0 0
MAP kinase activation R-HSA-450294 2.788492e-01 0.555 0 0
Neuronal System R-HSA-112316 1.390061e-01 0.857 1 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.906773e-01 0.309 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.208659e-01 0.494 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.423505e-01 0.847 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.756107e-01 0.425 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.756107e-01 0.425 0 0
Developmental Biology R-HSA-1266738 2.533506e-01 0.596 1 0
Potassium Channels R-HSA-1296071 4.644194e-01 0.333 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.906773e-01 0.309 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.906773e-01 0.309 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.208167e-01 0.918 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.204474e-01 0.919 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.349265e-01 0.362 0 0
Transmission across Chemical Synapses R-HSA-112315 5.601109e-01 0.252 1 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.417901e-01 0.617 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.555278e-01 0.341 0 0
Cilium Assembly R-HSA-5617833 4.564408e-01 0.341 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.376613e-01 0.861 0 0
Specification of the neural plate border R-HSA-9834899 5.236623e-01 0.281 0 0
Mitotic Anaphase R-HSA-68882 1.158793e-01 0.936 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.842294e-01 0.735 1 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.483209e-01 0.829 0 0
G0 and Early G1 R-HSA-1538133 2.777554e-01 0.556 0 0
Interleukin-17 signaling R-HSA-448424 4.132066e-01 0.384 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.089753e-01 0.388 0 0
DNA Repair R-HSA-73894 4.520509e-01 0.345 0 0
Inhibition of PKR R-HSA-169131 2.061835e-01 0.686 0 0
ARMS-mediated activation R-HSA-170984 1.629137e-01 0.788 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.629137e-01 0.788 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.361399e-01 0.627 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 3.698735e-01 0.432 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.698735e-01 0.432 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.303607e-01 0.885 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.023745e-01 0.694 0 0
MET interacts with TNS proteins R-HSA-8875513 4.385942e-01 0.358 0 0
Signaling by LTK R-HSA-9842663 2.820038e-01 0.550 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 1.811805e-01 0.742 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 4.998239e-01 0.301 0 0
Transmission across Electrical Synapses R-HSA-112307 4.998239e-01 0.301 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 2.250476e-01 0.648 1 1
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.425020e-01 0.354 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.790935e-01 0.421 0 0
Disorders of Developmental Biology R-HSA-9675151 4.367071e-01 0.360 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.803789e-01 0.318 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.543788e-01 0.256 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.543788e-01 0.256 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.187791e-01 0.497 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.166285e-01 0.287 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.954590e-01 0.305 0 0
Selective autophagy R-HSA-9663891 4.444391e-01 0.352 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.286596e-01 0.277 0 0
PI3K Cascade R-HSA-109704 5.042430e-01 0.297 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.519576e-01 0.258 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.202696e-01 0.284 0 0
Signalling to RAS R-HSA-167044 5.773389e-01 0.239 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.736074e-01 0.241 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.744810e-01 0.241 0 0
Metabolism of RNA R-HSA-8953854 4.658982e-01 0.332 0 0
Interleukin-1 family signaling R-HSA-446652 4.965009e-01 0.304 0 0
Cell junction organization R-HSA-446728 1.882795e-01 0.725 0 0
Signaling by NOTCH1 R-HSA-1980143 5.039117e-01 0.298 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.326038e-01 0.877 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.772730e-01 0.423 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.327627e-01 0.273 0 0
Ub-specific processing proteases R-HSA-5689880 5.428982e-01 0.265 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 5.047836e-01 0.297 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 2.722925e-01 0.565 1 1
FLT3 signaling in disease R-HSA-9682385 2.323858e-01 0.634 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.490965e-01 0.827 1 0
Cell-cell junction organization R-HSA-421270 5.449542e-01 0.264 0 0
Cardiac conduction R-HSA-5576891 2.605108e-01 0.584 0 0
Cell-Cell communication R-HSA-1500931 2.190447e-01 0.659 0 0
Programmed Cell Death R-HSA-5357801 3.005206e-01 0.522 0 0
Regulation of insulin secretion R-HSA-422356 2.826440e-01 0.549 1 1
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.690149e-01 0.772 0 0
Smooth Muscle Contraction R-HSA-445355 5.568364e-01 0.254 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.625050e-01 0.441 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.250681e-01 0.648 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.367071e-01 0.360 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.948336e-01 0.530 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.519576e-01 0.258 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.746308e-01 0.241 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.736074e-01 0.241 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.954590e-01 0.305 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.519576e-01 0.258 0 0
Apoptosis R-HSA-109581 2.023676e-01 0.694 0 0
Interleukin-1 processing R-HSA-448706 1.629137e-01 0.788 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.629137e-01 0.788 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.361399e-01 0.627 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.131838e-01 0.504 0 0
Heme signaling R-HSA-9707616 1.173946e-01 0.930 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.031426e-01 0.395 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.031426e-01 0.395 0 0
Protein hydroxylation R-HSA-9629569 3.272505e-01 0.485 0 0
Rab regulation of trafficking R-HSA-9007101 3.474076e-01 0.459 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.902388e-01 0.310 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.511553e-01 0.259 0 0
Disorders of Nervous System Development R-HSA-9697154 5.511553e-01 0.259 0 0
Pervasive developmental disorders R-HSA-9005895 5.511553e-01 0.259 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.753459e-01 0.240 0 0
Signaling by PTK6 R-HSA-8848021 4.349265e-01 0.362 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.349265e-01 0.362 0 0
Deubiquitination R-HSA-5688426 5.061203e-01 0.296 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.116905e-01 0.291 0 0
Reproduction R-HSA-1474165 2.511903e-01 0.600 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.031426e-01 0.395 0 0
TGFBR3 expression R-HSA-9839394 2.894300e-01 0.538 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.047836e-01 0.297 0 0
ISG15 antiviral mechanism R-HSA-1169408 4.889889e-01 0.311 0 0
Cardiogenesis R-HSA-9733709 2.973642e-01 0.527 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.216909e-01 0.915 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.303607e-01 0.885 0 0
Aquaporin-mediated transport R-HSA-445717 4.026487e-01 0.395 1 0
PI Metabolism R-HSA-1483255 2.397924e-01 0.620 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.763852e-01 0.558 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 2.370747e-01 0.625 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.664424e-01 0.331 0 0
Glycolysis R-HSA-70171 2.195556e-01 0.658 1 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.039560e-01 0.690 0 0
RUNX2 regulates bone development R-HSA-8941326 5.534139e-01 0.257 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.339969e-01 0.476 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.240355e-01 0.906 0 0
Kidney development R-HSA-9830369 3.675684e-01 0.435 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.927459e-01 0.534 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.361399e-01 0.627 0 0
DSCAM interactions R-HSA-376172 3.698735e-01 0.432 0 0
Tandem pore domain potassium channels R-HSA-1296346 1.912974e-01 0.718 0 0
Synthesis of PI R-HSA-1483226 2.207984e-01 0.656 0 0
Alpha-defensins R-HSA-1462054 3.625050e-01 0.441 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.444366e-01 0.463 0 0
Sensory perception of sour taste R-HSA-9729555 4.998239e-01 0.301 0 0
LTC4-CYSLTR mediated IL4 production R-HSA-9664535 4.425020e-01 0.354 0 0
Negative regulation of FLT3 R-HSA-9706369 4.063672e-01 0.391 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 5.543788e-01 0.256 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 3.865100e-01 0.413 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.384191e-01 0.358 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.773389e-01 0.239 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.746308e-01 0.241 0 0
Co-stimulation by CD28 R-HSA-389356 2.039560e-01 0.690 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.555278e-01 0.341 1 0
Stimuli-sensing channels R-HSA-2672351 4.139620e-01 0.383 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.782892e-01 0.320 0 0
Sensory processing of sound R-HSA-9659379 5.478723e-01 0.261 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.785885e-01 0.555 0 0
Histamine receptors R-HSA-390650 4.385942e-01 0.358 0 0
Selenocysteine synthesis R-HSA-2408557 1.587405e-01 0.799 0 0
Nuclear import of Rev protein R-HSA-180746 5.116905e-01 0.291 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.144350e-01 0.289 0 0
The NLRP3 inflammasome R-HSA-844456 5.236623e-01 0.281 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.323858e-01 0.634 0 0
Formation of the anterior neural plate R-HSA-9823739 3.755579e-01 0.425 0 0
Diseases of DNA repair R-HSA-9675135 4.312888e-01 0.365 0 0
Signaling by ALK R-HSA-201556 4.384191e-01 0.358 0 0
Signaling by TGFBR3 R-HSA-9839373 4.312888e-01 0.365 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.719237e-01 0.430 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.684539e-01 0.329 0 0
NrCAM interactions R-HSA-447038 1.941111e-01 0.712 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 2.361399e-01 0.627 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.208659e-01 0.494 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.208659e-01 0.494 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.385942e-01 0.358 0 0
Interleukin-18 signaling R-HSA-9012546 3.625050e-01 0.441 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.031426e-01 0.395 0 0
Dopamine receptors R-HSA-390651 4.998239e-01 0.301 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.998239e-01 0.301 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.543788e-01 0.256 0 0
G1/S-Specific Transcription R-HSA-69205 3.777329e-01 0.423 0 0
Glucose metabolism R-HSA-70326 3.474076e-01 0.459 1 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.684539e-01 0.329 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.894666e-01 0.410 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.590766e-01 0.338 0 0
Estrogen biosynthesis R-HSA-193144 5.511553e-01 0.259 0 0
Interleukin-7 signaling R-HSA-1266695 2.894300e-01 0.538 0 0
Nephrin family interactions R-HSA-373753 5.509757e-01 0.259 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.843194e-01 0.546 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.511553e-01 0.259 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.773389e-01 0.239 0 0
Cleavage of the damaged purine R-HSA-110331 5.736074e-01 0.241 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.031426e-01 0.395 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.803789e-01 0.318 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.543788e-01 0.256 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.463877e-01 0.350 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.545239e-01 0.594 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.760070e-01 0.559 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.531162e-01 0.452 0 0
Interleukin-15 signaling R-HSA-8983432 5.511553e-01 0.259 0 0
Influenza Infection R-HSA-168255 4.330062e-01 0.364 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.172753e-01 0.286 0 0
Depyrimidination R-HSA-73928 5.172753e-01 0.286 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.789827e-01 0.421 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.372822e-01 0.472 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.543788e-01 0.256 0 0
OAS antiviral response R-HSA-8983711 5.511553e-01 0.259 0 0
Platelet sensitization by LDL R-HSA-432142 2.760070e-01 0.559 0 0
Signaling by Leptin R-HSA-2586552 4.425020e-01 0.354 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.785730e-01 0.238 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.809706e-01 0.236 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.820100e-01 0.235 0 0
Processing of SMDT1 R-HSA-8949664 5.839038e-01 0.234 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.839038e-01 0.234 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.839038e-01 0.234 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.839038e-01 0.234 0 0
Ca2+ pathway R-HSA-4086398 5.900423e-01 0.229 0 0
Insulin receptor signalling cascade R-HSA-74751 5.900700e-01 0.229 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.900700e-01 0.229 0 0
Signaling by Interleukins R-HSA-449147 5.903138e-01 0.229 0 0
Telomere Maintenance R-HSA-157579 5.912926e-01 0.228 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.914554e-01 0.228 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.932759e-01 0.227 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 5.933117e-01 0.227 0 0
Depurination R-HSA-73927 5.933117e-01 0.227 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.933117e-01 0.227 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.966401e-01 0.224 0 0
DAP12 signaling R-HSA-2424491 5.966401e-01 0.224 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.966401e-01 0.224 0 0
Activation of BH3-only proteins R-HSA-114452 5.966401e-01 0.224 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.027066e-01 0.220 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.027066e-01 0.220 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.027066e-01 0.220 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.029861e-01 0.220 0 0
PKB-mediated events R-HSA-109703 6.029861e-01 0.220 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.029861e-01 0.220 0 0
Cam-PDE 1 activation R-HSA-111957 6.029861e-01 0.220 0 0
PDE3B signalling R-HSA-165160 6.029861e-01 0.220 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.029861e-01 0.220 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.029861e-01 0.220 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.029861e-01 0.220 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.029861e-01 0.220 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.029861e-01 0.220 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.029861e-01 0.220 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.029861e-01 0.220 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.029861e-01 0.220 0 0
NGF-independant TRKA activation R-HSA-187024 6.029861e-01 0.220 0 0
Phosphorylation of Emi1 R-HSA-176417 6.029861e-01 0.220 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.029861e-01 0.220 0 0
Synthesis of PS R-HSA-1483101 6.029861e-01 0.220 0 0
Formation of the Editosome R-HSA-75094 6.029861e-01 0.220 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.029861e-01 0.220 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.029861e-01 0.220 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.029861e-01 0.220 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.029861e-01 0.220 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.029861e-01 0.220 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.029861e-01 0.220 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.029861e-01 0.220 0 0
Cellular responses to stimuli R-HSA-8953897 6.050039e-01 0.218 1 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.053773e-01 0.218 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.068110e-01 0.217 0 0
Removal of the Flap Intermediate R-HSA-69166 6.148512e-01 0.211 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 6.148512e-01 0.211 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 6.148512e-01 0.211 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.148512e-01 0.211 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.148512e-01 0.211 0 0
Ribosome-associated quality control R-HSA-9948299 6.163333e-01 0.210 0 0
PPARA activates gene expression R-HSA-1989781 6.171030e-01 0.210 0 0
Membrane Trafficking R-HSA-199991 6.184751e-01 0.209 0 0
Protein ubiquitination R-HSA-8852135 6.186919e-01 0.209 0 0
Cellular responses to stress R-HSA-2262752 6.228790e-01 0.206 0 0
Signaling by KIT in disease R-HSA-9669938 6.270467e-01 0.203 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.270467e-01 0.203 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.270467e-01 0.203 0 0
FGFR2 alternative splicing R-HSA-6803529 6.270467e-01 0.203 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.270467e-01 0.203 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.270467e-01 0.203 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.270467e-01 0.203 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.276531e-01 0.202 0 0
Attenuation phase R-HSA-3371568 6.311484e-01 0.200 0 0
Generation of second messenger molecules R-HSA-202433 6.311484e-01 0.200 0 0
Interleukin-2 family signaling R-HSA-451927 6.311484e-01 0.200 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.311484e-01 0.200 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.311484e-01 0.200 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 6.365076e-01 0.196 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.440008e-01 0.191 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.440008e-01 0.191 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.440008e-01 0.191 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.440008e-01 0.191 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.440008e-01 0.191 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.440008e-01 0.191 0 0
p38MAPK events R-HSA-171007 6.440008e-01 0.191 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.440008e-01 0.191 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 6.440008e-01 0.191 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.440008e-01 0.191 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.440008e-01 0.191 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.440008e-01 0.191 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.440008e-01 0.191 0 0
STAT5 Activation R-HSA-9645135 6.462941e-01 0.190 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.462941e-01 0.190 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 6.462941e-01 0.190 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.462941e-01 0.190 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.462941e-01 0.190 0 0
NADPH regeneration R-HSA-389542 6.462941e-01 0.190 0 0
Lipid particle organization R-HSA-8964572 6.462941e-01 0.190 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.492397e-01 0.188 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.492397e-01 0.188 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.492397e-01 0.188 0 0
Formation of the ureteric bud R-HSA-9830674 6.503389e-01 0.187 0 0
Carnitine shuttle R-HSA-200425 6.503389e-01 0.187 0 0
Syndecan interactions R-HSA-3000170 6.503389e-01 0.187 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.536414e-01 0.185 0 0
Triglyceride metabolism R-HSA-8979227 6.536414e-01 0.185 1 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.584039e-01 0.182 0 0
G-protein beta:gamma signalling R-HSA-397795 6.584039e-01 0.182 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.596292e-01 0.181 0 0
Signaling by TGFB family members R-HSA-9006936 6.646950e-01 0.177 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.655052e-01 0.177 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.667589e-01 0.176 1 1
SLC-mediated transport of neurotransmitters R-HSA-442660 6.667589e-01 0.176 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.706981e-01 0.173 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.706981e-01 0.173 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.713765e-01 0.173 0 0
Killing mechanisms R-HSA-9664420 6.713765e-01 0.173 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.713765e-01 0.173 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.713765e-01 0.173 0 0
Regulation of BACH1 activity R-HSA-9708530 6.713765e-01 0.173 0 0
Activation of SMO R-HSA-5635838 6.713765e-01 0.173 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.713765e-01 0.173 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 6.713765e-01 0.173 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.713765e-01 0.173 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.713765e-01 0.173 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.713765e-01 0.173 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.713765e-01 0.173 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.725733e-01 0.172 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 6.725733e-01 0.172 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.725733e-01 0.172 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.775090e-01 0.169 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.848800e-01 0.164 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.848800e-01 0.164 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.848800e-01 0.164 0 0
Disinhibition of SNARE formation R-HSA-114516 6.848800e-01 0.164 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.848800e-01 0.164 0 0
mRNA Editing: C to U Conversion R-HSA-72200 6.848800e-01 0.164 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.848800e-01 0.164 0 0
Activation of TRKA receptors R-HSA-187015 6.848800e-01 0.164 0 0
Glycoprotein hormones R-HSA-209822 6.848800e-01 0.164 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.848800e-01 0.164 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.848800e-01 0.164 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.848800e-01 0.164 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 6.902959e-01 0.161 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.902959e-01 0.161 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.902959e-01 0.161 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.905743e-01 0.161 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.905743e-01 0.161 0 0
Hedgehog 'on' state R-HSA-5632684 6.905743e-01 0.161 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.937491e-01 0.159 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.937491e-01 0.159 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.937491e-01 0.159 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.958564e-01 0.157 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.958564e-01 0.157 0 0
Mitophagy R-HSA-5205647 6.958564e-01 0.157 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.970183e-01 0.157 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.970183e-01 0.157 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.970183e-01 0.157 0 0
Passive transport by Aquaporins R-HSA-432047 6.970183e-01 0.157 0 0
Synthesis of PG R-HSA-1483148 6.970183e-01 0.157 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.989572e-01 0.156 0 0
Signaling by FGFR4 R-HSA-5654743 7.000409e-01 0.155 0 0
TBC/RABGAPs R-HSA-8854214 7.000409e-01 0.155 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.014131e-01 0.154 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.014131e-01 0.154 0 0
Toll-like Receptor Cascades R-HSA-168898 7.046223e-01 0.152 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 7.138731e-01 0.146 0 0
Synthesis of DNA R-HSA-69239 7.181343e-01 0.144 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.192587e-01 0.143 0 0
Activation of RAS in B cells R-HSA-1169092 7.192587e-01 0.143 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.192587e-01 0.143 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.192587e-01 0.143 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.192587e-01 0.143 0 0
Regulation by c-FLIP R-HSA-3371378 7.192587e-01 0.143 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.192587e-01 0.143 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.192587e-01 0.143 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.192587e-01 0.143 0 0
Dimerization of procaspase-8 R-HSA-69416 7.192587e-01 0.143 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.192587e-01 0.143 0 0
Sodium/Proton exchangers R-HSA-425986 7.192587e-01 0.143 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.192587e-01 0.143 0 0
Translation initiation complex formation R-HSA-72649 7.194665e-01 0.143 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.194665e-01 0.143 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.194665e-01 0.143 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.198256e-01 0.143 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.209788e-01 0.142 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.209788e-01 0.142 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.209788e-01 0.142 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.209788e-01 0.142 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.209788e-01 0.142 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 7.209788e-01 0.142 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.209788e-01 0.142 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 7.209788e-01 0.142 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.209788e-01 0.142 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.219657e-01 0.141 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.237342e-01 0.140 0 0
HSF1 activation R-HSA-3371511 7.302732e-01 0.137 0 0
Glycosphingolipid transport R-HSA-9845576 7.302732e-01 0.137 0 0
Fanconi Anemia Pathway R-HSA-6783310 7.309472e-01 0.136 0 0
Signaling by FGFR3 R-HSA-5654741 7.309472e-01 0.136 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.309472e-01 0.136 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.329589e-01 0.135 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.329589e-01 0.135 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.329589e-01 0.135 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.329589e-01 0.135 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.433194e-01 0.129 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.433194e-01 0.129 0 0
Mismatch Repair R-HSA-5358508 7.433194e-01 0.129 0 0
Tie2 Signaling R-HSA-210993 7.433194e-01 0.129 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.433194e-01 0.129 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.445131e-01 0.128 1 1
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.455076e-01 0.128 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.455076e-01 0.128 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.455076e-01 0.128 0 0
Voltage gated Potassium channels R-HSA-1296072 7.463504e-01 0.127 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.463504e-01 0.127 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.466735e-01 0.127 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 7.466735e-01 0.127 0 0
Interleukin-21 signaling R-HSA-9020958 7.498885e-01 0.125 0 0
CASP8 activity is inhibited R-HSA-5218900 7.498885e-01 0.125 0 0
ALK mutants bind TKIs R-HSA-9700645 7.498885e-01 0.125 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.498885e-01 0.125 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.498885e-01 0.125 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.498885e-01 0.125 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.498885e-01 0.125 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.498885e-01 0.125 0 0
mRNA Editing R-HSA-75072 7.498885e-01 0.125 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.498885e-01 0.125 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.498885e-01 0.125 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.498885e-01 0.125 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.498885e-01 0.125 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.498885e-01 0.125 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.501416e-01 0.125 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.510256e-01 0.124 0 0
Inflammasomes R-HSA-622312 7.510256e-01 0.124 0 0
Interleukin-12 signaling R-HSA-9020591 7.519634e-01 0.124 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.594770e-01 0.119 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 7.594770e-01 0.119 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.641085e-01 0.117 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.641085e-01 0.117 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.641085e-01 0.117 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.641085e-01 0.117 0 0
G alpha (s) signalling events R-HSA-418555 7.648135e-01 0.116 1 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.648135e-01 0.116 1 0
Cytokine Signaling in Immune system R-HSA-1280215 7.650625e-01 0.116 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.658768e-01 0.116 0 0
Inositol phosphate metabolism R-HSA-1483249 7.666481e-01 0.115 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.680971e-01 0.115 0 0
mRNA Capping R-HSA-72086 7.680971e-01 0.115 0 0
Late endosomal microautophagy R-HSA-9615710 7.680971e-01 0.115 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.680971e-01 0.115 0 0
Platelet calcium homeostasis R-HSA-418360 7.680971e-01 0.115 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.689394e-01 0.114 0 0
Dual incision in TC-NER R-HSA-6782135 7.719208e-01 0.112 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.719208e-01 0.112 0 0
Adherens junctions interactions R-HSA-418990 7.737996e-01 0.111 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.771781e-01 0.109 0 0
DNA replication initiation R-HSA-68952 7.771781e-01 0.109 0 0
Regulation of CDH11 function R-HSA-9762292 7.771781e-01 0.109 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.771781e-01 0.109 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.771781e-01 0.109 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.771781e-01 0.109 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.771781e-01 0.109 0 0
Pexophagy R-HSA-9664873 7.771781e-01 0.109 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.771781e-01 0.109 0 0
Maturation of spike protein R-HSA-9683686 7.771781e-01 0.109 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.771781e-01 0.109 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.771781e-01 0.109 0 0
Peptide hormone biosynthesis R-HSA-209952 7.771781e-01 0.109 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.771781e-01 0.109 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.791024e-01 0.108 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.834185e-01 0.106 0 0
Glycogen synthesis R-HSA-3322077 7.834185e-01 0.106 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.834185e-01 0.106 0 0
Extension of Telomeres R-HSA-180786 7.838180e-01 0.106 0 0
Regulation of beta-cell development R-HSA-186712 7.838180e-01 0.106 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.842010e-01 0.106 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.842010e-01 0.106 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.856680e-01 0.105 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.856680e-01 0.105 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.901747e-01 0.102 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.901747e-01 0.102 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.901747e-01 0.102 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.901747e-01 0.102 0 0
Diseases of Immune System R-HSA-5260271 7.901747e-01 0.102 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.943063e-01 0.100 0 0
Signaling by FGFR2 R-HSA-5654738 7.945128e-01 0.100 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.979069e-01 0.098 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.979069e-01 0.098 0 0
Platelet homeostasis R-HSA-418346 7.989059e-01 0.098 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.993679e-01 0.097 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.993679e-01 0.097 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.002502e-01 0.097 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.013247e-01 0.096 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.013247e-01 0.096 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 8.013247e-01 0.096 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.013247e-01 0.096 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.013247e-01 0.096 0 0
Lagging Strand Synthesis R-HSA-69186 8.013247e-01 0.096 0 0
ERK/MAPK targets R-HSA-198753 8.013247e-01 0.096 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.013247e-01 0.096 0 0
ChREBP activates metabolic gene expression R-HSA-163765 8.014915e-01 0.096 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.014915e-01 0.096 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.014915e-01 0.096 0 0
Interleukin-2 signaling R-HSA-9020558 8.014915e-01 0.096 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.014915e-01 0.096 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.014915e-01 0.096 0 0
Bicarbonate transporters R-HSA-425381 8.014915e-01 0.096 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.014915e-01 0.096 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.014915e-01 0.096 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.014915e-01 0.096 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.014915e-01 0.096 0 0
LGI-ADAM interactions R-HSA-5682910 8.014915e-01 0.096 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.014915e-01 0.096 0 0
Suppression of apoptosis R-HSA-9635465 8.014915e-01 0.096 0 0
PECAM1 interactions R-HSA-210990 8.014915e-01 0.096 0 0
rRNA processing R-HSA-72312 8.025370e-01 0.096 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.061884e-01 0.094 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.095888e-01 0.092 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.136308e-01 0.090 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.158682e-01 0.088 0 0
HIV Transcription Initiation R-HSA-167161 8.158682e-01 0.088 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.158682e-01 0.088 0 0
Intra-Golgi traffic R-HSA-6811438 8.158682e-01 0.088 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.158682e-01 0.088 1 1
NCAM signaling for neurite out-growth R-HSA-375165 8.166767e-01 0.088 0 0
L1CAM interactions R-HSA-373760 8.168361e-01 0.088 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 8.179034e-01 0.087 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.179034e-01 0.087 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.179034e-01 0.087 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.179034e-01 0.087 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.231533e-01 0.085 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.231533e-01 0.085 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.231533e-01 0.085 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.231533e-01 0.085 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.231533e-01 0.085 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.231533e-01 0.085 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.231533e-01 0.085 0 0
Sodium/Calcium exchangers R-HSA-425561 8.231533e-01 0.085 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.231533e-01 0.085 0 0
TCR signaling R-HSA-202403 8.308373e-01 0.080 0 0
DNA Replication R-HSA-69306 8.310636e-01 0.080 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.328331e-01 0.079 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.332311e-01 0.079 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.332311e-01 0.079 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.332311e-01 0.079 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.332311e-01 0.079 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.387088e-01 0.076 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.389183e-01 0.076 0 0
Selenoamino acid metabolism R-HSA-2408522 8.391145e-01 0.076 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.395845e-01 0.076 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.395845e-01 0.076 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.424524e-01 0.074 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.424524e-01 0.074 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.424524e-01 0.074 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.424524e-01 0.074 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.424524e-01 0.074 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.424524e-01 0.074 0 0
MET activates RAS signaling R-HSA-8851805 8.424524e-01 0.074 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.424524e-01 0.074 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.424524e-01 0.074 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.424524e-01 0.074 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.424524e-01 0.074 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.424524e-01 0.074 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.424524e-01 0.074 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.424524e-01 0.074 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.473833e-01 0.072 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.473833e-01 0.072 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.473833e-01 0.072 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.473833e-01 0.072 0 0
Growth hormone receptor signaling R-HSA-982772 8.473833e-01 0.072 0 0
Amine ligand-binding receptors R-HSA-375280 8.495054e-01 0.071 0 0
DAP12 interactions R-HSA-2172127 8.495054e-01 0.071 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.510068e-01 0.070 0 0
Signaling by NOTCH3 R-HSA-9012852 8.510068e-01 0.070 0 0
Dual Incision in GG-NER R-HSA-5696400 8.513480e-01 0.070 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.513480e-01 0.070 0 0
Signaling by NOTCH2 R-HSA-1980145 8.513480e-01 0.070 0 0
Neutrophil degranulation R-HSA-6798695 8.538172e-01 0.069 0 0
HIV Life Cycle R-HSA-162587 8.550880e-01 0.068 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.554447e-01 0.068 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.594973e-01 0.066 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.594973e-01 0.066 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.594973e-01 0.066 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.596464e-01 0.066 0 0
FGFR2c ligand binding and activation R-HSA-190375 8.596464e-01 0.066 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.596464e-01 0.066 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.596464e-01 0.066 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.596464e-01 0.066 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 8.596464e-01 0.066 0 0
Acetylcholine binding and downstream events R-HSA-181431 8.596464e-01 0.066 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 8.596464e-01 0.066 0 0
Chylomicron remodeling R-HSA-8963901 8.596464e-01 0.066 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.596464e-01 0.066 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.596464e-01 0.066 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.596464e-01 0.066 0 0
FGFR3 mutant receptor activation R-HSA-2033514 8.596464e-01 0.066 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.596464e-01 0.066 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 8.596464e-01 0.066 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.596464e-01 0.066 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.596464e-01 0.066 0 0
Maturation of nucleoprotein R-HSA-9683610 8.596464e-01 0.066 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.596464e-01 0.066 0 0
Signaling by FGFR1 R-HSA-5654736 8.601067e-01 0.065 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.604340e-01 0.065 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.604340e-01 0.065 0 0
TNFs bind their physiological receptors R-HSA-5669034 8.604340e-01 0.065 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.623518e-01 0.064 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.623518e-01 0.064 0 0
Adaptive Immune System R-HSA-1280218 8.625647e-01 0.064 1 0
Interleukin-12 family signaling R-HSA-447115 8.628303e-01 0.064 0 0
Developmental Cell Lineages R-HSA-9734767 8.635309e-01 0.064 0 0
Nucleotide Excision Repair R-HSA-5696398 8.660500e-01 0.062 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.689170e-01 0.061 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.689170e-01 0.061 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.689170e-01 0.061 0 0
Regulated Necrosis R-HSA-5218859 8.704625e-01 0.060 0 0
Potential therapeutics for SARS R-HSA-9679191 8.707835e-01 0.060 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.712755e-01 0.060 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.724549e-01 0.059 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.724549e-01 0.059 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.724549e-01 0.059 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.726329e-01 0.059 0 0
GPVI-mediated activation cascade R-HSA-114604 8.726329e-01 0.059 0 0
Ion channel transport R-HSA-983712 8.738315e-01 0.059 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.749648e-01 0.058 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.749648e-01 0.058 0 0
FGFR3c ligand binding and activation R-HSA-190372 8.749648e-01 0.058 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 8.749648e-01 0.058 0 0
Prolactin receptor signaling R-HSA-1170546 8.749648e-01 0.058 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.749648e-01 0.058 0 0
Malate-aspartate shuttle R-HSA-9856872 8.749648e-01 0.058 0 0
Ciprofloxacin ADME R-HSA-9793528 8.749648e-01 0.058 0 0
Signal regulatory protein family interactions R-HSA-391160 8.749648e-01 0.058 0 0
P2Y receptors R-HSA-417957 8.749648e-01 0.058 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.749648e-01 0.058 0 0
Recycling pathway of L1 R-HSA-437239 8.777879e-01 0.057 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.777879e-01 0.057 0 0
Gene Silencing by RNA R-HSA-211000 8.785088e-01 0.056 0 0
Co-inhibition by PD-1 R-HSA-389948 8.794209e-01 0.056 0 0
Signaling by MET R-HSA-6806834 8.802487e-01 0.055 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.810717e-01 0.055 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.822281e-01 0.054 0 0
Base Excision Repair R-HSA-73884 8.831653e-01 0.054 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.835154e-01 0.054 0 0
Myogenesis R-HSA-525793 8.835154e-01 0.054 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.835154e-01 0.054 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.835154e-01 0.054 0 0
Metalloprotease DUBs R-HSA-5689901 8.835154e-01 0.054 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.835154e-01 0.054 0 0
Abacavir ADME R-HSA-2161522 8.835154e-01 0.054 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.835154e-01 0.054 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.835154e-01 0.054 0 0
Intraflagellar transport R-HSA-5620924 8.861337e-01 0.053 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.869084e-01 0.052 0 0
Amyloid fiber formation R-HSA-977225 8.869084e-01 0.052 0 0
Mitochondrial biogenesis R-HSA-1592230 8.883768e-01 0.051 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.886122e-01 0.051 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.886122e-01 0.051 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.886122e-01 0.051 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.886122e-01 0.051 0 0
Signaling by Activin R-HSA-1502540 8.886122e-01 0.051 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.886122e-01 0.051 0 0
Biotin transport and metabolism R-HSA-196780 8.886122e-01 0.051 0 0
FGFR3 ligand binding and activation R-HSA-190239 8.886122e-01 0.051 0 0
DNA Damage Reversal R-HSA-73942 8.886122e-01 0.051 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.887172e-01 0.051 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.893630e-01 0.051 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.907214e-01 0.050 0 0
GABA receptor activation R-HSA-977443 8.919666e-01 0.050 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.919928e-01 0.050 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.936819e-01 0.049 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.936819e-01 0.049 0 0
Cristae formation R-HSA-8949613 8.936819e-01 0.049 0 0
Insulin processing R-HSA-264876 8.936819e-01 0.049 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.936819e-01 0.049 0 0
DNA Damage Bypass R-HSA-73893 8.939775e-01 0.049 0 0
IRE1alpha activates chaperones R-HSA-381070 8.952841e-01 0.048 0 0
Leishmania infection R-HSA-9658195 8.960150e-01 0.048 1 0
Parasitic Infection Pathways R-HSA-9824443 8.960150e-01 0.048 1 0
Interleukin-1 signaling R-HSA-9020702 8.977932e-01 0.047 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.984578e-01 0.047 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.995050e-01 0.046 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.007707e-01 0.045 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.007707e-01 0.045 0 0
Fructose catabolism R-HSA-70350 9.007707e-01 0.045 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.007707e-01 0.045 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 9.007707e-01 0.045 0 0
Atorvastatin ADME R-HSA-9754706 9.007707e-01 0.045 0 0
Signaling by Insulin receptor R-HSA-74752 9.009369e-01 0.045 0 0
Pyrimidine salvage R-HSA-73614 9.030176e-01 0.044 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.030176e-01 0.044 0 0
HCMV Early Events R-HSA-9609690 9.036657e-01 0.044 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.050470e-01 0.043 0 0
tRNA processing in the nucleus R-HSA-6784531 9.054057e-01 0.043 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.063299e-01 0.043 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.072568e-01 0.042 0 0
GPCR downstream signalling R-HSA-388396 9.078206e-01 0.042 1 0
The phototransduction cascade R-HSA-2514856 9.082521e-01 0.042 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.115828e-01 0.040 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 9.115828e-01 0.040 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.116026e-01 0.040 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.116026e-01 0.040 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.116026e-01 0.040 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.116026e-01 0.040 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.116026e-01 0.040 0 0
Galactose catabolism R-HSA-70370 9.116026e-01 0.040 0 0
Coenzyme A biosynthesis R-HSA-196783 9.116026e-01 0.040 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.116026e-01 0.040 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.144627e-01 0.039 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.158962e-01 0.038 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.194344e-01 0.036 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.194344e-01 0.036 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.207929e-01 0.036 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.207929e-01 0.036 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.207929e-01 0.036 0 0
Host Interactions of HIV factors R-HSA-162909 9.211220e-01 0.036 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.211550e-01 0.036 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.212527e-01 0.036 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.212527e-01 0.036 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.212527e-01 0.036 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.212527e-01 0.036 0 0
Glycogen storage diseases R-HSA-3229121 9.212527e-01 0.036 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.212527e-01 0.036 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.212527e-01 0.036 0 0
Catecholamine biosynthesis R-HSA-209905 9.212527e-01 0.036 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.212527e-01 0.036 0 0
Cellular response to hypoxia R-HSA-1234174 9.228241e-01 0.035 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.241119e-01 0.034 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.266261e-01 0.033 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.266261e-01 0.033 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.298499e-01 0.032 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.298499e-01 0.032 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.298499e-01 0.032 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.298499e-01 0.032 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.298499e-01 0.032 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.298499e-01 0.032 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.298499e-01 0.032 0 0
Nephron development R-HSA-9831926 9.298499e-01 0.032 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.321127e-01 0.031 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.327968e-01 0.030 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.331230e-01 0.030 0 0
Signaling by FGFR R-HSA-190236 9.337052e-01 0.030 0 0
Phospholipid metabolism R-HSA-1483257 9.360642e-01 0.029 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.367305e-01 0.028 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.371722e-01 0.028 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.373376e-01 0.028 0 0
Pyrimidine biosynthesis R-HSA-500753 9.375089e-01 0.028 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.375089e-01 0.028 0 0
Regulation of signaling by CBL R-HSA-912631 9.375089e-01 0.028 0 0
Diseases of hemostasis R-HSA-9671793 9.375089e-01 0.028 0 0
Maturation of nucleoprotein R-HSA-9694631 9.375089e-01 0.028 0 0
Other interleukin signaling R-HSA-449836 9.375089e-01 0.028 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.375089e-01 0.028 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.384574e-01 0.028 0 0
Surfactant metabolism R-HSA-5683826 9.384574e-01 0.028 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.391913e-01 0.027 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 9.392285e-01 0.027 0 0
HIV Infection R-HSA-162906 9.405841e-01 0.027 0 0
Cellular response to chemical stress R-HSA-9711123 9.424414e-01 0.026 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.443321e-01 0.025 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.443321e-01 0.025 0 0
Pregnenolone biosynthesis R-HSA-196108 9.443321e-01 0.025 0 0
Signal transduction by L1 R-HSA-445144 9.443321e-01 0.025 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.447307e-01 0.025 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.447307e-01 0.025 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.447307e-01 0.025 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.447307e-01 0.025 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.456747e-01 0.024 0 0
Interferon gamma signaling R-HSA-877300 9.457207e-01 0.024 0 0
Gastrulation R-HSA-9758941 9.471853e-01 0.024 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.478153e-01 0.023 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.496988e-01 0.022 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.497564e-01 0.022 0 0
Signal amplification R-HSA-392518 9.497564e-01 0.022 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.502327e-01 0.022 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.504106e-01 0.022 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.504106e-01 0.022 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.504106e-01 0.022 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.504106e-01 0.022 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.504106e-01 0.022 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.504106e-01 0.022 0 0
Basigin interactions R-HSA-210991 9.504106e-01 0.022 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.515265e-01 0.022 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.534475e-01 0.021 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.535446e-01 0.021 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.543439e-01 0.020 0 0
Oncogene Induced Senescence R-HSA-2559585 9.543439e-01 0.020 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.558257e-01 0.020 0 0
Attachment and Entry R-HSA-9694614 9.558257e-01 0.020 0 0
Metal ion SLC transporters R-HSA-425410 9.560876e-01 0.020 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.569372e-01 0.019 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.585290e-01 0.018 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.585290e-01 0.018 0 0
Signaling by NOTCH4 R-HSA-9013694 9.592366e-01 0.018 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.594347e-01 0.018 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.596889e-01 0.018 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.601839e-01 0.018 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.606498e-01 0.017 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.606498e-01 0.017 0 0
Fructose metabolism R-HSA-5652084 9.606498e-01 0.017 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.606498e-01 0.017 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.606498e-01 0.017 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.621169e-01 0.017 0 0
Degradation of DVL R-HSA-4641258 9.623448e-01 0.017 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.623448e-01 0.017 0 0
NCAM1 interactions R-HSA-419037 9.623448e-01 0.017 0 0
Collagen chain trimerization R-HSA-8948216 9.623448e-01 0.017 0 0
UCH proteinases R-HSA-5689603 9.648091e-01 0.016 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.649473e-01 0.015 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.649473e-01 0.015 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.649473e-01 0.015 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.649473e-01 0.015 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.649473e-01 0.015 0 0
Biosynthesis of maresins R-HSA-9018682 9.649473e-01 0.015 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.649473e-01 0.015 0 0
Elastic fibre formation R-HSA-1566948 9.658222e-01 0.015 0 0
Ion transport by P-type ATPases R-HSA-936837 9.660073e-01 0.015 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.687757e-01 0.014 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.687757e-01 0.014 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.687757e-01 0.014 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.687757e-01 0.014 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.687757e-01 0.014 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.688976e-01 0.014 0 0
Downstream TCR signaling R-HSA-202424 9.713926e-01 0.013 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.718727e-01 0.012 0 0
Leishmania phagocytosis R-HSA-9664417 9.720125e-01 0.012 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.720125e-01 0.012 0 0
Parasite infection R-HSA-9664407 9.720125e-01 0.012 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.721862e-01 0.012 0 0
G protein gated Potassium channels R-HSA-1296059 9.721862e-01 0.012 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.721862e-01 0.012 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.721862e-01 0.012 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.721862e-01 0.012 0 0
Laminin interactions R-HSA-3000157 9.721862e-01 0.012 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.721862e-01 0.012 0 0
Maturation of spike protein R-HSA-9694548 9.744963e-01 0.011 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.744963e-01 0.011 0 0
MET activates PTK2 signaling R-HSA-8874081 9.752243e-01 0.011 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.752243e-01 0.011 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.752243e-01 0.011 0 0
Urea cycle R-HSA-70635 9.752243e-01 0.011 0 0
Sphingolipid catabolism R-HSA-9845614 9.752243e-01 0.011 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.753504e-01 0.011 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.755125e-01 0.011 0 0
Translation of Structural Proteins R-HSA-9683701 9.768826e-01 0.010 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.769375e-01 0.010 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.779308e-01 0.010 0 0
Triglyceride biosynthesis R-HSA-75109 9.779308e-01 0.010 0 0
Synthesis of PE R-HSA-1483213 9.779308e-01 0.010 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.779308e-01 0.010 0 0
Signaling by BMP R-HSA-201451 9.779308e-01 0.010 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.781155e-01 0.010 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.783371e-01 0.010 0 0
Signaling by NOTCH R-HSA-157118 9.790516e-01 0.009 0 0
Activation of GABAB receptors R-HSA-991365 9.790521e-01 0.009 0 0
GABA B receptor activation R-HSA-977444 9.790521e-01 0.009 0 0
Collagen formation R-HSA-1474290 9.800245e-01 0.009 0 0
Prednisone ADME R-HSA-9757110 9.803417e-01 0.009 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.803417e-01 0.009 0 0
Pyroptosis R-HSA-5620971 9.803417e-01 0.009 0 0
SARS-CoV Infections R-HSA-9679506 9.804674e-01 0.009 0 0
Defensins R-HSA-1461973 9.810236e-01 0.008 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.812562e-01 0.008 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.814957e-01 0.008 1 1
trans-Golgi Network Vesicle Budding R-HSA-199992 9.822389e-01 0.008 0 0
Thyroxine biosynthesis R-HSA-209968 9.824894e-01 0.008 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.824894e-01 0.008 0 0
Glucagon-type ligand receptors R-HSA-420092 9.824894e-01 0.008 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.824894e-01 0.008 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.824894e-01 0.008 0 0
Platelet degranulation R-HSA-114608 9.826499e-01 0.008 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.830618e-01 0.007 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.832530e-01 0.007 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.839683e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.844026e-01 0.007 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.844026e-01 0.007 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.844408e-01 0.007 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.844408e-01 0.007 0 0
Vesicle-mediated transport R-HSA-5653656 9.854379e-01 0.006 0 0
Signaling by GPCR R-HSA-372790 9.857633e-01 0.006 1 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.859169e-01 0.006 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.860131e-01 0.006 0 0
Nucleotide salvage R-HSA-8956321 9.860131e-01 0.006 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.861068e-01 0.006 0 0
Budding and maturation of HIV virion R-HSA-162588 9.861068e-01 0.006 0 0
Cargo concentration in the ER R-HSA-5694530 9.861068e-01 0.006 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.861068e-01 0.006 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.861068e-01 0.006 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.861068e-01 0.006 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.861632e-01 0.006 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.872239e-01 0.006 0 0
Mitochondrial protein import R-HSA-1268020 9.872239e-01 0.006 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.872564e-01 0.006 0 0
Hemostasis R-HSA-109582 9.874991e-01 0.005 1 0
HS-GAG degradation R-HSA-2024096 9.876249e-01 0.005 0 0
Gluconeogenesis R-HSA-70263 9.884714e-01 0.005 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.889772e-01 0.005 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.889772e-01 0.005 0 0
Recycling of bile acids and salts R-HSA-159418 9.889772e-01 0.005 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.889772e-01 0.005 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.891394e-01 0.005 0 0
PCP/CE pathway R-HSA-4086400 9.892537e-01 0.005 0 0
Interleukin-10 signaling R-HSA-6783783 9.892537e-01 0.005 0 0
Cholesterol biosynthesis R-HSA-191273 9.892537e-01 0.005 0 0
Integrin cell surface interactions R-HSA-216083 9.892537e-01 0.005 0 0
Neddylation R-HSA-8951664 9.894318e-01 0.005 0 0
Degradation of CDH1 R-HSA-9766229 9.895731e-01 0.005 0 0
Gap junction trafficking and regulation R-HSA-157858 9.895731e-01 0.005 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.901285e-01 0.004 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.901818e-01 0.004 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.901818e-01 0.004 0 0
Heme degradation R-HSA-189483 9.901818e-01 0.004 0 0
Interferon Signaling R-HSA-913531 9.908170e-01 0.004 0 0
PKR-mediated signaling R-HSA-9833482 9.909350e-01 0.004 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.912548e-01 0.004 0 0
eNOS activation R-HSA-203615 9.912548e-01 0.004 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.912548e-01 0.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.912548e-01 0.004 0 0
Gap junction assembly R-HSA-190861 9.912548e-01 0.004 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.912644e-01 0.004 1 0
Hedgehog ligand biogenesis R-HSA-5358346 9.914768e-01 0.004 0 0
RSV-host interactions R-HSA-9833110 9.918628e-01 0.004 0 0
Metabolism of steroid hormones R-HSA-196071 9.919133e-01 0.004 0 0
G alpha (i) signalling events R-HSA-418594 9.920093e-01 0.003 1 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.920127e-01 0.003 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.922106e-01 0.003 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.922106e-01 0.003 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.922106e-01 0.003 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.922106e-01 0.003 0 0
PERK regulates gene expression R-HSA-381042 9.922106e-01 0.003 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.922106e-01 0.003 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.922967e-01 0.003 0 0
HCMV Infection R-HSA-9609646 9.927190e-01 0.003 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.929932e-01 0.003 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.930392e-01 0.003 0 0
Nucleotide biosynthesis R-HSA-8956320 9.930392e-01 0.003 0 0
HS-GAG biosynthesis R-HSA-2022928 9.930620e-01 0.003 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.930620e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.930620e-01 0.003 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.931821e-01 0.003 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.932659e-01 0.003 1 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.932659e-01 0.003 1 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.937115e-01 0.003 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.938204e-01 0.003 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.938204e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.938204e-01 0.003 0 0
COPII-mediated vesicle transport R-HSA-204005 9.938752e-01 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.938752e-01 0.003 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.943201e-01 0.002 0 0
G alpha (z) signalling events R-HSA-418597 9.943201e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.944201e-01 0.002 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.944959e-01 0.002 0 0
Purine salvage R-HSA-74217 9.944959e-01 0.002 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.944959e-01 0.002 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.948707e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.950500e-01 0.002 0 0
SLC transporter disorders R-HSA-5619102 9.950705e-01 0.002 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.950976e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.950976e-01 0.002 0 0
Stabilization of p53 R-HSA-69541 9.950976e-01 0.002 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.950976e-01 0.002 0 0
Regulation of CDH1 Function R-HSA-9764561 9.953690e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.953690e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.953690e-01 0.002 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.956336e-01 0.002 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.961110e-01 0.002 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.961110e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.961110e-01 0.002 0 0
Iron uptake and transport R-HSA-917937 9.961658e-01 0.002 0 0
Peroxisomal protein import R-HSA-9033241 9.962271e-01 0.002 0 0
Immune System R-HSA-168256 9.962335e-01 0.002 1 0
ER to Golgi Anterograde Transport R-HSA-199977 9.963678e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.965183e-01 0.002 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.965362e-01 0.002 0 0
Heme biosynthesis R-HSA-189451 9.965362e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.965954e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.966299e-01 0.001 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.967758e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9694635 9.968263e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.969150e-01 0.001 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.969150e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.969284e-01 0.001 0 0
ABC transporter disorders R-HSA-5619084 9.971135e-01 0.001 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.972523e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.972523e-01 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.973331e-01 0.001 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.975528e-01 0.001 0 0
Gap junction trafficking R-HSA-190828 9.975528e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.975528e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.977701e-01 0.001 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.978205e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.978205e-01 0.001 0 0
Somitogenesis R-HSA-9824272 9.978205e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.978964e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.980588e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.981196e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.981686e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.982307e-01 0.001 0 0
HCMV Late Events R-HSA-9610379 9.982384e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.982712e-01 0.001 0 0
Synthesis of PC R-HSA-1483191 9.982712e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.983493e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.983493e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.984603e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.985124e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.986120e-01 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.986287e-01 0.001 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.988953e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.989122e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.989122e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.989122e-01 0.000 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.989123e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.989123e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.990202e-01 0.000 0 0
Protein localization R-HSA-9609507 9.991150e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.992055e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.992457e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.993158e-01 0.000 0 0
Protein folding R-HSA-391251 9.993848e-01 0.000 0 0
Digestion R-HSA-8935690 9.993907e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.995696e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.995942e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.996098e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.996168e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.996168e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.996200e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.996486e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.996587e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.997208e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.997293e-01 0.000 0 0
ABC-family proteins mediated transport R-HSA-382556 9.997472e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.997590e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.997716e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.997781e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.997854e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.998375e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.998540e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998598e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998930e-01 0.000 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.998973e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999151e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999161e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999173e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999327e-01 0.000 0 0
tRNA processing R-HSA-72306 9.999368e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999443e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999443e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.999516e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999525e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.999551e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999551e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999587e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999648e-01 0.000 1 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999665e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999738e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999763e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999782e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999789e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999851e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999877e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999895e-01 0.000 0 0
Translation R-HSA-72766 9.999904e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999914e-01 0.000 1 0
FCGR activation R-HSA-2029481 9.999934e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999936e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999963e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999969e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999973e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999993e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999997e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999999e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 1 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 1 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 1 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 1 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 1 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Apoptotic execution phase R-HSA-75153 0.000004 5.423 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.000005 5.333 0 0
Cellular response to heat stress R-HSA-3371556 0.000004 5.351 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.000007 5.136 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.000013 4.873 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.000017 4.780 0 0
M Phase R-HSA-68886 0.000030 4.523 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.000030 4.527 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 0.000037 4.437 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.000036 4.442 0 0
Cell Cycle R-HSA-1640170 0.000075 4.123 0 0
IRE1alpha activates chaperones R-HSA-381070 0.000079 4.101 0 0
Attenuation phase R-HSA-3371568 0.000089 4.050 0 0
Chromatin organization R-HSA-4839726 0.000087 4.063 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.000113 3.947 0 0
HSF1-dependent transactivation R-HSA-3371571 0.000130 3.886 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 0.000135 3.869 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.000140 3.853 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.000144 3.843 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.000181 3.742 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.000172 3.765 0 0
Cell Cycle, Mitotic R-HSA-69278 0.000205 3.689 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.000226 3.646 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.000229 3.640 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.000229 3.640 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.000292 3.534 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.000292 3.534 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.000287 3.543 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.000294 3.532 0 0
Chromatin modifying enzymes R-HSA-3247509 0.000261 3.583 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.000287 3.543 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.000335 3.475 0 0
ESR-mediated signaling R-HSA-8939211 0.000337 3.473 0 0
HSF1 activation R-HSA-3371511 0.000370 3.431 0 0
Metabolism of RNA R-HSA-8953854 0.000385 3.415 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.000476 3.323 0 0
Cellular responses to stimuli R-HSA-8953897 0.000473 3.325 1 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.000532 3.274 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.000574 3.241 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.000599 3.222 0 0
G alpha (12/13) signalling events R-HSA-416482 0.000712 3.148 0 0
Nuclear import of Rev protein R-HSA-180746 0.000749 3.125 0 0
Mitotic Prometaphase R-HSA-68877 0.000833 3.079 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.000867 3.062 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.000908 3.042 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.000923 3.035 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.000929 3.032 0 0
mRNA Splicing R-HSA-72172 0.001263 2.898 0 0
Cellular responses to stress R-HSA-2262752 0.001302 2.885 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.001360 2.866 0 0
snRNP Assembly R-HSA-191859 0.001469 2.833 0 0
Metabolism of non-coding RNA R-HSA-194441 0.001469 2.833 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.001507 2.822 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.002002 2.698 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.002298 2.639 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.002583 2.588 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.002583 2.588 0 0
Opioid Signalling R-HSA-111885 0.002489 2.604 1 0
DAG and IP3 signaling R-HSA-1489509 0.002587 2.587 1 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.002684 2.571 1 1
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.002933 2.533 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.003047 2.516 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.003393 2.469 0 0
Calmodulin induced events R-HSA-111933 0.003296 2.482 1 0
CaM pathway R-HSA-111997 0.003296 2.482 1 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.004091 2.388 0 0
GPER1 signaling R-HSA-9634597 0.004169 2.380 1 1
Ca-dependent events R-HSA-111996 0.004105 2.387 1 0
Notch-HLH transcription pathway R-HSA-350054 0.004232 2.373 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.004421 2.354 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 0.005239 2.281 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.005281 2.277 0 0
Mitotic Anaphase R-HSA-68882 0.005207 2.283 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.005568 2.254 0 0
tRNA processing in the nucleus R-HSA-6784531 0.005339 2.273 0 0
NRAGE signals death through JNK R-HSA-193648 0.005501 2.260 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.005908 2.229 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.006072 2.217 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.006072 2.217 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 0.006520 2.186 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.006542 2.184 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.006969 2.157 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.006969 2.157 0 0
HIV Life Cycle R-HSA-162587 0.007151 2.146 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.007244 2.140 0 0
Formation of annular gap junctions R-HSA-196025 0.007726 2.112 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 0.007726 2.112 1 1
Signaling by VEGF R-HSA-194138 0.007438 2.129 1 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 0.007742 2.111 0 0
Mitotic Prophase R-HSA-68875 0.008102 2.091 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.008154 2.089 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.008770 2.057 0 0
Signaling by LTK R-HSA-9842663 0.008995 2.046 0 0
Nervous system development R-HSA-9675108 0.008450 2.073 1 0
Disorders of Developmental Biology R-HSA-9675151 0.009135 2.039 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.009270 2.033 0 0
Death Receptor Signaling R-HSA-73887 0.009797 2.009 0 0
PLC beta mediated events R-HSA-112043 0.010427 1.982 1 0
Viral Messenger RNA Synthesis R-HSA-168325 0.010427 1.982 0 0
Gap junction degradation R-HSA-190873 0.010935 1.961 0 0
Centrosome maturation R-HSA-380287 0.011529 1.938 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.011529 1.938 0 0
Signaling by Hippo R-HSA-2028269 0.011545 1.938 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.011597 1.936 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.011830 1.927 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 0.011830 1.927 1 1
Regulation of MECP2 expression and activity R-HSA-9022692 0.011983 1.921 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.012433 1.905 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.013530 1.869 1 0
Axon guidance R-HSA-422475 0.013113 1.882 1 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.013589 1.867 0 0
Signaling by ALK in cancer R-HSA-9700206 0.013589 1.867 0 0
Cellular Senescence R-HSA-2559583 0.013800 1.860 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 0.014043 1.853 1 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.014384 1.842 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 0.015467 1.811 1 1
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.015732 1.803 0 0
mRNA 3'-end processing R-HSA-72187 0.016687 1.778 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.016434 1.784 0 0
Apoptosis R-HSA-109581 0.017111 1.767 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.017556 1.756 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.017556 1.756 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.017587 1.755 1 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 0.017870 1.748 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 0.017870 1.748 0 0
Signal Transduction R-HSA-162582 0.017882 1.748 1 0
Separation of Sister Chromatids R-HSA-2467813 0.019493 1.710 0 0
DNA Double Strand Break Response R-HSA-5693606 0.020316 1.692 0 0
G-protein mediated events R-HSA-112040 0.020316 1.692 1 0
Signaling by ERBB2 R-HSA-1227986 0.019681 1.706 0 0
p75NTR signals via NF-kB R-HSA-193639 0.019279 1.715 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.019279 1.715 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.018784 1.726 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.020605 1.686 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.020605 1.686 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.020605 1.686 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.020605 1.686 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.020605 1.686 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 0.020605 1.686 0 0
RET signaling R-HSA-8853659 0.021815 1.661 1 1
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.022347 1.651 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.022349 1.651 0 0
Glycolysis R-HSA-70171 0.022725 1.643 1 0
MECP2 regulates transcription factors R-HSA-9022707 0.025047 1.601 0 0
Cell Cycle Checkpoints R-HSA-69620 0.024657 1.608 0 0
Signaling by AXIN mutants R-HSA-4839735 0.025695 1.590 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.025834 1.588 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 0.025834 1.588 1 1
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.026280 1.580 0 0
Myogenesis R-HSA-525793 0.026280 1.580 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.026763 1.572 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.027333 1.563 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.027501 1.561 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.029417 1.531 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 0.030736 1.512 0 0
Integrin signaling R-HSA-354192 0.029802 1.526 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.029417 1.531 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 0.030668 1.513 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.030339 1.518 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.031948 1.496 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.031948 1.496 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.032375 1.490 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.032539 1.488 0 0
Disorders of Nervous System Development R-HSA-9697154 0.032539 1.488 0 0
Pervasive developmental disorders R-HSA-9005895 0.032539 1.488 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.032539 1.488 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 0.032539 1.488 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.032968 1.482 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.033734 1.472 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 0.034042 1.468 1 1
Striated Muscle Contraction R-HSA-390522 0.034115 1.467 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.035021 1.456 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.035835 1.446 1 1
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.040894 1.388 0 0
Signal amplification R-HSA-392518 0.038839 1.411 0 0
DARPP-32 events R-HSA-180024 0.040894 1.388 1 1
HATs acetylate histones R-HSA-3214847 0.036946 1.432 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.037351 1.428 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.039455 1.404 0 0
Programmed Cell Death R-HSA-5357801 0.039604 1.402 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.041573 1.381 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 0.042319 1.373 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 0.042326 1.373 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 0.042541 1.371 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.042541 1.371 0 0
Presynaptic function of Kainate receptors R-HSA-500657 0.042541 1.371 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.042789 1.369 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 0.043185 1.365 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 0.043185 1.365 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 0.043185 1.365 0 0
Breakdown of the nuclear lamina R-HSA-352238 0.043185 1.365 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.043364 1.363 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.043968 1.357 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.046766 1.330 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.047039 1.328 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.044631 1.350 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.046089 1.336 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.046766 1.330 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.049363 1.307 0 0
Neurodegenerative Diseases R-HSA-8863678 0.049054 1.309 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 0.049054 1.309 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.049054 1.309 1 1
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.044682 1.350 0 0
Signaling by ROBO receptors R-HSA-376176 0.050345 1.298 1 0
RUNX2 regulates bone development R-HSA-8941326 0.049577 1.305 0 0
Influenza Infection R-HSA-168255 0.049157 1.308 0 0
MTOR signalling R-HSA-165159 0.051225 1.291 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 0.051225 1.291 1 1
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.052178 1.283 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.054758 1.262 0 0
Signal attenuation R-HSA-74749 0.055752 1.254 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 0.055752 1.254 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 0.058421 1.233 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.058421 1.233 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 0.058421 1.233 1 1
Co-inhibition by CTLA4 R-HSA-389513 0.058843 1.230 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.059378 1.226 0 0
G beta:gamma signalling through BTK R-HSA-8964315 0.059378 1.226 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.071561 1.145 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.071561 1.145 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 0.071561 1.145 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.071561 1.145 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.071561 1.145 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.071561 1.145 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.071561 1.145 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.071561 1.145 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.071561 1.145 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.071561 1.145 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.071561 1.145 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.071561 1.145 0 0
Signaling by APC mutants R-HSA-4839744 0.069064 1.161 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.069064 1.161 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.069064 1.161 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.069064 1.161 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.067569 1.170 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.069460 1.158 0 0
G-protein beta:gamma signalling R-HSA-397795 0.067569 1.170 0 0
Nuclear RNA decay R-HSA-9930044 0.067569 1.170 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.069064 1.161 0 0
EPHB-mediated forward signaling R-HSA-3928662 0.062980 1.201 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.069460 1.158 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.072846 1.138 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.073122 1.136 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.075590 1.122 0 0
HIV Infection R-HSA-162906 0.075617 1.121 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.076967 1.114 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.076967 1.114 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.077406 1.111 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 0.078402 1.106 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.078732 1.104 0 0
Muscle contraction R-HSA-397014 0.079316 1.101 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.082609 1.083 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.097742 1.010 0 0
Disinhibition of SNARE formation R-HSA-114516 0.097742 1.010 0 0
SOS-mediated signalling R-HSA-112412 0.097742 1.010 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.083855 1.076 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 0.100057 1.000 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.100057 1.000 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.100057 1.000 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.100057 1.000 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.100057 1.000 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.100057 1.000 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.100057 1.000 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.100057 1.000 0 0
mTORC1-mediated signalling R-HSA-166208 0.089396 1.049 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.092745 1.033 0 0
Signaling by EGFR R-HSA-177929 0.096898 1.014 0 0
NF-kB is activated and signals survival R-HSA-209560 0.083855 1.076 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.099468 1.002 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 0.087103 1.060 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.100057 1.000 0 0
Membrane Trafficking R-HSA-199991 0.086777 1.062 0 0
Ion homeostasis R-HSA-5578775 0.096898 1.014 0 0
EPH-Ephrin signaling R-HSA-2682334 0.098974 1.004 0 0
p75NTR recruits signalling complexes R-HSA-209543 0.100057 1.000 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.083855 1.076 0 0
NCAM signaling for neurite out-growth R-HSA-375165 0.087103 1.060 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.091044 1.041 0 0
Glucose metabolism R-HSA-70326 0.088257 1.054 1 0
Intracellular signaling by second messengers R-HSA-9006925 0.101433 0.994 1 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 0.103071 0.987 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 0.103371 0.986 0 0
PDGFR mutants bind TKIs R-HSA-9674428 0.103371 0.986 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 0.103371 0.986 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 0.103371 0.986 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 0.103371 0.986 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 0.103371 0.986 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 0.103371 0.986 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 0.103371 0.986 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 0.104296 0.982 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 0.104296 0.982 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 0.104296 0.982 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 0.104296 0.982 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 0.104296 0.982 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 0.104296 0.982 0 0
Regulation of CDH1 Function R-HSA-9764561 0.104757 0.980 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.104854 0.979 0 0
Gene Silencing by RNA R-HSA-211000 0.107848 0.967 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.109956 0.959 0 0
PKA activation R-HSA-163615 0.109956 0.959 1 1
PKA activation in glucagon signalling R-HSA-164378 0.109956 0.959 1 1
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.109956 0.959 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.109956 0.959 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 0.140186 0.853 0 0
Regulation of gap junction activity R-HSA-191650 0.140186 0.853 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 0.140186 0.853 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 0.140186 0.853 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 0.140186 0.853 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 0.136334 0.865 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.113743 0.944 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.135072 0.869 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.125157 0.903 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 0.120499 0.919 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.126210 0.899 0 0
Signaling by WNT in cancer R-HSA-4791275 0.126210 0.899 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.113126 0.946 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.119849 0.921 0 0
Circadian clock R-HSA-9909396 0.139246 0.856 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 0.125079 0.903 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.139626 0.855 0 0
Regulation of KIT signaling R-HSA-1433559 0.136334 0.865 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.127049 0.896 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.113126 0.946 0 0
Deubiquitination R-HSA-5688426 0.117875 0.929 0 0
Aquaporin-mediated transport R-HSA-445717 0.139768 0.855 1 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.127786 0.894 0 0
Rap1 signalling R-HSA-392517 0.125079 0.903 1 1
L1CAM interactions R-HSA-373760 0.126941 0.896 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.120499 0.919 0 0
Host Interactions of HIV factors R-HSA-162909 0.127033 0.896 0 0
HDL assembly R-HSA-8963896 0.136334 0.865 1 1
Inositol phosphate metabolism R-HSA-1483249 0.140150 0.853 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 0.141070 0.851 0 0
Formation of definitive endoderm R-HSA-9823730 0.141100 0.850 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.141456 0.849 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.141456 0.849 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.144980 0.839 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 0.144980 0.839 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.144980 0.839 0 0
Aggrephagy R-HSA-9646399 0.146797 0.833 0 0
Autophagy R-HSA-9612973 0.148938 0.827 0 0
Macroautophagy R-HSA-1632852 0.151214 0.820 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.151731 0.819 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 0.196063 0.708 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 0.196063 0.708 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 0.196063 0.708 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 0.196063 0.708 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 0.196063 0.708 0 0
TICAM1 deficiency - HSE R-HSA-5602566 0.196063 0.708 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 0.196063 0.708 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 0.196063 0.708 0 0
TRAF3 deficiency - HSE R-HSA-5602571 0.279176 0.554 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 0.279176 0.554 0 0
Defective VWF binding to collagen type I R-HSA-9845622 0.279176 0.554 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 0.279176 0.554 0 0
IKBKB deficiency causes SCID R-HSA-5602636 0.279176 0.554 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 0.279176 0.554 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 0.279176 0.554 0 0
Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) R-HSA-5619053 0.279176 0.554 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 0.279176 0.554 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 0.178230 0.749 0 0
IRS activation R-HSA-74713 0.178230 0.749 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.178230 0.749 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 0.178230 0.749 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 0.217599 0.662 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 0.353702 0.451 0 0
Defective visual phototransduction due to RDH12 loss of function R-HSA-9918440 0.353702 0.451 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 0.353702 0.451 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 0.353702 0.451 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 0.353702 0.451 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 0.353702 0.451 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 0.170917 0.767 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 0.170917 0.767 0 0
2-LTR circle formation R-HSA-164843 0.170917 0.767 0 0
Folding of actin by CCT/TriC R-HSA-390450 0.170917 0.767 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 0.257614 0.589 0 0
Erythropoietin activates STAT5 R-HSA-9027283 0.257614 0.589 0 0
Autointegration results in viral DNA circles R-HSA-177539 0.257614 0.589 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.198046 0.703 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 0.198046 0.703 0 0
Erythropoietin activates RAS R-HSA-9027284 0.156199 0.806 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.156199 0.806 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 0.177060 0.752 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.177060 0.752 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 0.177060 0.752 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 0.226111 0.646 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 0.226111 0.646 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.226111 0.646 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 0.297721 0.526 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 0.297721 0.526 0 0
TRIF-mediated programmed cell death R-HSA-2562578 0.297721 0.526 0 0
Recycling of eIF2:GDP R-HSA-72731 0.297721 0.526 0 0
The NLRP1 inflammasome R-HSA-844455 0.420526 0.376 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.420526 0.376 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 0.420526 0.376 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 0.420526 0.376 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 0.420526 0.376 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 0.420526 0.376 0 0
Defective ABCC2 causes DJS R-HSA-5679001 0.420526 0.376 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 0.420526 0.376 0 0
Defective gamma-carboxylation of F9 R-HSA-9673240 0.420526 0.376 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 0.420526 0.376 0 0
Repression of WNT target genes R-HSA-4641265 0.254869 0.594 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.221280 0.655 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.221280 0.655 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.221280 0.655 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 0.221280 0.655 0 0
FGFR2 alternative splicing R-HSA-6803529 0.193935 0.712 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 0.284092 0.547 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 0.284092 0.547 0 0
Late endosomal microautophagy R-HSA-9615710 0.187046 0.728 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.232435 0.634 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 0.232435 0.634 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.232435 0.634 0 0
WNT mediated activation of DVL R-HSA-201688 0.376516 0.424 0 0
Calcineurin activates NFAT R-HSA-2025928 0.376516 0.424 0 0
TNFR1-mediated ceramide production R-HSA-5626978 0.480445 0.318 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 0.480445 0.318 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.480445 0.318 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 0.480445 0.318 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.480445 0.318 0 0
G protein gated Potassium channels R-HSA-1296059 0.252445 0.598 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 0.252445 0.598 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 0.252445 0.598 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.343110 0.465 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.343110 0.465 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 0.343110 0.465 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.316245 0.500 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.316245 0.500 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.414572 0.382 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.190090 0.721 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.190090 0.721 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.293604 0.532 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.153309 0.814 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.213668 0.670 0 0
Phosphorylation of the APC/C R-HSA-176412 0.372540 0.429 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.241031 0.618 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.226937 0.644 0 0
Translation initiation complex formation R-HSA-72649 0.240503 0.619 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.162564 0.789 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 0.534171 0.272 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.534171 0.272 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 0.534171 0.272 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 0.534171 0.272 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 0.534171 0.272 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 0.534171 0.272 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.268437 0.571 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.278756 0.555 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.486921 0.313 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 0.486921 0.313 0 0
Meiotic synapsis R-HSA-1221632 0.350038 0.456 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.350038 0.456 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.284474 0.546 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.284474 0.546 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.313168 0.504 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 0.406550 0.391 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.442068 0.355 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.461643 0.336 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 0.486356 0.313 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 0.486356 0.313 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.486356 0.313 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 0.486356 0.313 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.520945 0.283 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.520945 0.283 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.520945 0.283 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.582344 0.235 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 0.582344 0.235 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.582344 0.235 0 0
Phosphorylation of Emi1 R-HSA-176417 0.582344 0.235 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 0.582344 0.235 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 0.582344 0.235 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 0.582344 0.235 0 0
Signaling by RNF43 mutants R-HSA-5340588 0.582344 0.235 0 0
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) R-HSA-5619063 0.582344 0.235 0 0
Peptide chain elongation R-HSA-156902 0.371017 0.431 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 0.444678 0.352 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.444678 0.352 1 1
HIV Transcription Initiation R-HSA-167161 0.444678 0.352 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 0.444678 0.352 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.410078 0.387 0 0
Activation of GABAB receptors R-HSA-991365 0.463562 0.334 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 0.513287 0.290 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 0.513287 0.290 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 0.513287 0.290 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 0.513287 0.290 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.463737 0.334 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.463668 0.334 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 0.482275 0.317 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 0.553421 0.257 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.553421 0.257 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.553421 0.257 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 0.539446 0.268 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 0.539446 0.268 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.539446 0.268 0 0
Signaling by Erythropoietin R-HSA-9006335 0.530546 0.275 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 0.530546 0.275 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 0.519054 0.285 0 0
Nucleosome assembly R-HSA-774815 0.519054 0.285 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.519054 0.285 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.537057 0.270 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.564778 0.248 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 0.564778 0.248 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.587462 0.231 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.587462 0.231 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 0.594810 0.226 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.593892 0.226 0 0
Transcription of the HIV genome R-HSA-167172 0.587462 0.231 0 0
PKR-mediated signaling R-HSA-9833482 0.367126 0.435 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.529787 0.276 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.357077 0.447 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 0.483647 0.315 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.348247 0.458 0 0
EGFR downregulation R-HSA-182971 0.220516 0.657 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.272860 0.564 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.476292 0.322 0 0
Nucleotide Excision Repair R-HSA-5696398 0.401140 0.397 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.255563 0.593 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.461788 0.336 0 0
Downstream signal transduction R-HSA-186763 0.573970 0.241 0 0
Crosslinking of collagen fibrils R-HSA-2243919 0.486356 0.313 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.340656 0.468 0 0
HCMV Early Events R-HSA-9609690 0.257031 0.590 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 0.165324 0.782 0 0
Ephrin signaling R-HSA-3928664 0.458723 0.338 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.279267 0.554 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 0.430473 0.366 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.421744 0.375 0 0
Ribosome-associated quality control R-HSA-9948299 0.427469 0.369 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.501014 0.300 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 0.486921 0.313 0 0
GABA B receptor activation R-HSA-977444 0.463562 0.334 0 0
Activation of the pre-replicative complex R-HSA-68962 0.552538 0.258 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.335784 0.474 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.270459 0.568 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.157531 0.803 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.183215 0.737 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.258526 0.587 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 0.553421 0.257 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.478521 0.320 0 0
Integration of provirus R-HSA-162592 0.226111 0.646 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.293604 0.532 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.376318 0.424 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.376318 0.424 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.376318 0.424 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 0.170917 0.767 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.170917 0.767 0 0
G-protein activation R-HSA-202040 0.157961 0.801 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.349093 0.457 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 0.420968 0.376 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.444678 0.352 1 1
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 0.589239 0.230 0 0
Meiosis R-HSA-1500620 0.435428 0.361 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.178230 0.749 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.297721 0.526 0 0
Signalling to RAS R-HSA-167044 0.157961 0.801 0 0
Signal regulatory protein family interactions R-HSA-391160 0.313570 0.504 0 0
PI3K/AKT activation R-HSA-198203 0.414572 0.382 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 0.372540 0.429 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.451426 0.345 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.234660 0.630 0 0
MET activates RAS signaling R-HSA-8851805 0.520945 0.283 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.462977 0.334 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.398755 0.399 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.568700 0.245 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.571223 0.243 0 0
Homology Directed Repair R-HSA-5693538 0.370705 0.431 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.230249 0.638 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.571223 0.243 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.511252 0.291 0 0
Resolution of D-Loop Structures R-HSA-5693537 0.273964 0.562 0 0
Mismatch Repair R-HSA-5358508 0.458723 0.338 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 0.157961 0.801 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.212906 0.672 0 0
Thromboxane signalling through TP receptor R-HSA-428930 0.232435 0.634 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 0.255785 0.592 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.279104 0.554 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 0.582344 0.235 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.504033 0.298 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.564778 0.248 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.305464 0.515 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.498979 0.302 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.498979 0.302 0 0
TNF signaling R-HSA-75893 0.268437 0.571 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.237951 0.624 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.402561 0.395 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.425661 0.371 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.600004 0.222 0 0
Signaling by FGFR1 R-HSA-5654736 0.548052 0.261 0 0
UCH proteinases R-HSA-5689603 0.313513 0.504 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.501014 0.300 0 0
Post NMDA receptor activation events R-HSA-438064 0.254945 0.594 1 0
Oncogenic MAPK signaling R-HSA-6802957 0.319802 0.495 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.226111 0.646 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.425661 0.371 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.444678 0.352 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.552538 0.258 0 0
Gap junction trafficking and regulation R-HSA-157858 0.589202 0.230 0 0
PCP/CE pathway R-HSA-4086400 0.594159 0.226 0 0
IGF1R signaling cascade R-HSA-2428924 0.387306 0.412 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.532320 0.274 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.461643 0.336 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.523091 0.281 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.595827 0.225 0 0
G alpha (z) signalling events R-HSA-418597 0.156547 0.805 0 0
MAP kinase activation R-HSA-450294 0.226510 0.645 0 0
Abacavir transmembrane transport R-HSA-2161517 0.257614 0.589 0 0
PTK6 Expression R-HSA-8849473 0.297721 0.526 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.267998 0.572 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.401706 0.396 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.357077 0.447 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 0.357077 0.447 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.197313 0.705 0 0
Signaling by RAS mutants R-HSA-6802949 0.376318 0.424 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.520945 0.283 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.485049 0.314 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.524094 0.281 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.590393 0.229 0 0
Signaling by WNT R-HSA-195721 0.502490 0.299 0 0
Signaling by NOTCH3 R-HSA-9012852 0.156547 0.805 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.203530 0.691 0 0
Protein folding R-HSA-391251 0.555868 0.255 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.399251 0.399 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 0.486356 0.313 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.389729 0.409 0 0
Interleukin-17 signaling R-HSA-448424 0.348247 0.458 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.333945 0.476 0 0
Acyl chain remodelling of PS R-HSA-1482801 0.437875 0.359 0 0
Hedgehog 'off' state R-HSA-5610787 0.551498 0.258 1 1
NGF-stimulated transcription R-HSA-9031628 0.271104 0.567 0 0
Diseases of programmed cell death R-HSA-9645723 0.489800 0.310 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.547552 0.262 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.348908 0.457 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.292350 0.534 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 0.461643 0.336 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.376821 0.424 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.217599 0.662 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 0.480445 0.318 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 0.582344 0.235 0 0
Eukaryotic Translation Termination R-HSA-72764 0.606234 0.217 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.198717 0.702 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.287432 0.541 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.170256 0.769 0 0
Neurofascin interactions R-HSA-447043 0.257614 0.589 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.326839 0.486 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.326839 0.486 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.326839 0.486 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.326839 0.486 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.382473 0.417 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.406385 0.391 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.584306 0.233 0 0
Vesicle-mediated transport R-HSA-5653656 0.577407 0.239 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.255930 0.592 0 0
Signaling by NOTCH4 R-HSA-9013694 0.405595 0.392 0 0
HCMV Infection R-HSA-9609646 0.559247 0.252 0 0
Gene expression (Transcription) R-HSA-74160 0.319549 0.495 0 0
Cilium Assembly R-HSA-5617833 0.595903 0.225 0 0
DNA Repair R-HSA-73894 0.309704 0.509 0 0
Regulation of insulin secretion R-HSA-422356 0.306826 0.513 1 1
MAPK6/MAPK4 signaling R-HSA-5687128 0.560760 0.251 1 1
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.461788 0.336 1 0
Selective autophagy R-HSA-9663891 0.266278 0.575 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.526462 0.279 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.526462 0.279 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.526462 0.279 0 0
RNA Polymerase II Transcription R-HSA-73857 0.606753 0.217 0 0
Inhibition of PKR R-HSA-169131 0.196063 0.708 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 0.279176 0.554 0 0
Transport of connexins along the secretory pathway R-HSA-190827 0.279176 0.554 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 0.279176 0.554 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 0.178230 0.749 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 0.353702 0.451 0 0
Signalling to ERK5 R-HSA-198765 0.353702 0.451 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 0.177060 0.752 1 1
Cation-coupled Chloride cotransporters R-HSA-426117 0.297721 0.526 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 0.420526 0.376 0 0
MET interacts with TNS proteins R-HSA-8875513 0.420526 0.376 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.193935 0.712 0 0
Interleukin-37 signaling R-HSA-9008059 0.203530 0.691 0 0
Unwinding of DNA R-HSA-176974 0.376516 0.424 0 0
Alanine metabolism R-HSA-8964540 0.480445 0.318 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 0.480445 0.318 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 0.480445 0.318 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.159340 0.798 0 0
Regulation of CDH11 function R-HSA-9762292 0.414572 0.382 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 0.401706 0.396 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 0.451426 0.345 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 0.534171 0.272 0 0
Reelin signalling pathway R-HSA-8866376 0.534171 0.272 0 0
G2/M Checkpoints R-HSA-69481 0.216186 0.665 0 0
Smooth Muscle Contraction R-HSA-445355 0.350038 0.456 0 0
Recycling pathway of L1 R-HSA-437239 0.393867 0.405 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 0.486356 0.313 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 0.520945 0.283 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.582344 0.235 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 0.582344 0.235 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 0.582344 0.235 0 0
rRNA processing R-HSA-72312 0.274866 0.561 0 0
Formation of axial mesoderm R-HSA-9796292 0.553421 0.257 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.461788 0.336 0 0
Regulation of gene expression in beta cells R-HSA-210745 0.530546 0.275 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 0.584306 0.233 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.559446 0.252 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.157961 0.801 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.356913 0.447 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.183415 0.737 1 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.574151 0.241 0 0
Co-stimulation by CD28 R-HSA-389356 0.271104 0.567 0 0
Neurexins and neuroligins R-HSA-6794361 0.333945 0.476 0 0
HDMs demethylate histones R-HSA-3214842 0.252445 0.598 0 0
Protein ubiquitination R-HSA-8852135 0.420007 0.377 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.564778 0.248 0 0
Integration of energy metabolism R-HSA-163685 0.502867 0.299 1 0
PERK regulates gene expression R-HSA-381042 0.483647 0.315 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.532364 0.274 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.341824 0.466 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.605765 0.218 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 0.376516 0.424 0 0
Activation of ATR in response to replication stress R-HSA-176187 0.255785 0.592 0 0
Ca2+ pathway R-HSA-4086398 0.274633 0.561 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 0.530546 0.275 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.311151 0.507 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.158149 0.801 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.158149 0.801 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.482275 0.317 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.155771 0.808 0 0
Receptor Mediated Mitophagy R-HSA-8934903 0.414572 0.382 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 0.534171 0.272 0 0
Inwardly rectifying K+ channels R-HSA-1296065 0.399731 0.398 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 0.508035 0.294 0 0
ERK/MAPK targets R-HSA-198753 0.539446 0.268 0 0
Rab regulation of trafficking R-HSA-9007101 0.566847 0.247 0 0
Cardiac conduction R-HSA-5576891 0.437943 0.359 0 0
Signaling by NOTCH R-HSA-157118 0.553468 0.257 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.303515 0.518 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.175596 0.755 0 0
Activation of BH3-only proteins R-HSA-114452 0.552538 0.258 0 0
Negative regulation of MET activity R-HSA-6807004 0.513287 0.290 0 0
Signaling by FGFR in disease R-HSA-1226099 0.191380 0.718 0 0
RMTs methylate histone arginines R-HSA-3214858 0.500783 0.300 0 0
Signaling by FGFR R-HSA-190236 0.526462 0.279 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 0.297721 0.526 0 0
Uptake and function of anthrax toxins R-HSA-5210891 0.221280 0.655 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 0.513287 0.290 0 0
Heme signaling R-HSA-9707616 0.495635 0.305 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.480021 0.319 0 0
Signaling by NOTCH1 R-HSA-1980143 0.313513 0.504 0 0
Regulation of beta-cell development R-HSA-186712 0.447525 0.349 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.197461 0.705 0 0
Cell-Cell communication R-HSA-1500931 0.310497 0.508 0 0
Cell junction organization R-HSA-446728 0.291552 0.535 0 0
S Phase R-HSA-69242 0.358657 0.445 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.362499 0.441 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 0.520945 0.283 0 0
Signaling by NTRKs R-HSA-166520 0.277502 0.557 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 0.255785 0.592 0 0
Adherens junctions interactions R-HSA-418990 0.370030 0.432 0 0
TBC/RABGAPs R-HSA-8854214 0.324035 0.489 0 0
Cell-cell junction organization R-HSA-421270 0.420096 0.377 0 0
Interleukin-15 signaling R-HSA-8983432 0.520945 0.283 0 0
G2/M Transition R-HSA-69275 0.246357 0.608 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.456910 0.340 1 1
Signaling by KIT in disease R-HSA-9669938 0.589239 0.230 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.261552 0.582 0 0
Semaphorin interactions R-HSA-373755 0.159340 0.798 0 0
Oligomerization of connexins into connexons R-HSA-190704 0.279176 0.554 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 0.257614 0.589 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 0.156199 0.806 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.171111 0.767 0 0
Maturation of nucleoprotein R-HSA-9683610 0.284092 0.547 0 0
Platelet sensitization by LDL R-HSA-432142 0.244388 0.612 0 0
Physiological factors R-HSA-5578768 0.313570 0.504 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 0.401706 0.396 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 0.451426 0.345 0 0
Synthesis of PI R-HSA-1483226 0.451426 0.345 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 0.451426 0.345 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 0.486921 0.313 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.326839 0.486 0 0
RAF activation R-HSA-5673000 0.462977 0.334 0 0
Creatine metabolism R-HSA-71288 0.513287 0.290 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.435428 0.361 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 0.480963 0.318 0 0
Diseases of DNA repair R-HSA-9675135 0.537057 0.270 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.164418 0.784 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.159001 0.799 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.326839 0.486 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 0.284092 0.547 0 0
Protein hydroxylation R-HSA-9629569 0.513287 0.290 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.582547 0.235 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.530760 0.275 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.376516 0.424 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.420968 0.376 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.587462 0.231 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.237407 0.625 0 0
Regulation of TP53 Activity R-HSA-5633007 0.235263 0.628 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 0.198795 0.702 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.289294 0.539 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.345236 0.462 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 0.316245 0.500 0 0
OAS antiviral response R-HSA-8983711 0.520945 0.283 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 0.293604 0.532 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 0.217599 0.662 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 0.353702 0.451 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.177060 0.752 0 0
Anchoring fibril formation R-HSA-2214320 0.226111 0.646 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.480445 0.318 0 0
TGFBR3 expression R-HSA-9839394 0.252445 0.598 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 0.343110 0.465 0 0
Fibronectin matrix formation R-HSA-1566977 0.401706 0.396 0 0
Bicarbonate transporters R-HSA-425381 0.451426 0.345 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 0.534171 0.272 0 0
NrCAM interactions R-HSA-447038 0.534171 0.272 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.420968 0.376 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 0.582344 0.235 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 0.513287 0.290 0 0
Signalling to ERKs R-HSA-187687 0.483647 0.315 0 0
Triglyceride metabolism R-HSA-8979227 0.595827 0.225 1 0
DNA Damage Bypass R-HSA-73893 0.589202 0.230 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.480963 0.318 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.504033 0.298 0 0
Interleukin-7 signaling R-HSA-1266695 0.252445 0.598 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.480963 0.318 0 0
Maturation of nucleoprotein R-HSA-9694631 0.486356 0.313 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.607761 0.216 0 0
Specification of primordial germ cells R-HSA-9827857 0.221280 0.655 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.589239 0.230 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 0.178230 0.749 0 0
Regulated proteolysis of p75NTR R-HSA-193692 0.376516 0.424 0 0
Interleukin-1 processing R-HSA-448706 0.376516 0.424 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 0.582344 0.235 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.582344 0.235 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.563100 0.249 0 0
tRNA processing R-HSA-72306 0.409364 0.388 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.411417 0.386 0 0
Collagen chain trimerization R-HSA-8948216 0.524094 0.281 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.462977 0.334 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.171111 0.767 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 0.582344 0.235 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.462977 0.334 0 0
Plasma lipoprotein assembly R-HSA-8963898 0.232435 0.634 1 0
STING mediated induction of host immune responses R-HSA-1834941 0.486356 0.313 0 0
ChREBP activates metabolic gene expression R-HSA-163765 0.451426 0.345 0 0
P2Y receptors R-HSA-417957 0.584306 0.233 0 0
PECAM1 interactions R-HSA-210990 0.451426 0.345 0 0
Glucagon-type ligand receptors R-HSA-420092 0.335784 0.474 0 0
Signaling by Leptin R-HSA-2586552 0.414572 0.382 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 0.553421 0.257 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 0.584306 0.233 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.612795 0.213 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 0.612795 0.213 0 0
Growth hormone receptor signaling R-HSA-982772 0.612795 0.213 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 0.613582 0.212 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 0.613582 0.212 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 0.613582 0.212 0 0
DCC mediated attractive signaling R-HSA-418885 0.613582 0.212 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 0.613582 0.212 0 0
p38MAPK events R-HSA-171007 0.613582 0.212 0 0
Signaling by Activin R-HSA-1502540 0.613582 0.212 0 0
Protein methylation R-HSA-8876725 0.613582 0.212 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.613582 0.212 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.615031 0.211 0 0
Regulation of necroptotic cell death R-HSA-5675482 0.615031 0.211 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.616398 0.210 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.616420 0.210 0 0
MAP2K and MAPK activation R-HSA-5674135 0.618385 0.209 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.618385 0.209 1 1
Signaling by FGFR2 R-HSA-5654738 0.621131 0.207 0 0
Signaling by Hedgehog R-HSA-5358351 0.621384 0.207 1 0
Signaling by LTK in cancer R-HSA-9842640 0.625538 0.204 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 0.625538 0.204 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 0.625538 0.204 0 0
CREB phosphorylation R-HSA-199920 0.625538 0.204 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 0.625538 0.204 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 0.625538 0.204 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 0.625538 0.204 0 0
G2/M DNA replication checkpoint R-HSA-69478 0.625538 0.204 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.625538 0.204 0 0
Lactose synthesis R-HSA-5653890 0.625538 0.204 0 0
Nef and signal transduction R-HSA-164944 0.625538 0.204 0 0
HDL clearance R-HSA-8964011 0.625538 0.204 0 0
CREB3 factors activate genes R-HSA-8874211 0.625538 0.204 0 0
Reproduction R-HSA-1474165 0.626766 0.203 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.630233 0.200 0 0
Effects of PIP2 hydrolysis R-HSA-114508 0.634612 0.197 0 0
Platelet homeostasis R-HSA-418346 0.634742 0.197 0 0
Deadenylation of mRNA R-HSA-429947 0.635425 0.197 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.635864 0.197 0 0
Cellular response to starvation R-HSA-9711097 0.640027 0.194 0 0
Signaling by PDGF R-HSA-186797 0.640883 0.193 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 0.641251 0.193 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 0.641251 0.193 0 0
Differentiation of T cells R-HSA-9945266 0.641251 0.193 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.641251 0.193 0 0
Atorvastatin ADME R-HSA-9754706 0.641251 0.193 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.643935 0.191 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.647137 0.189 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.653535 0.185 0 0
eNOS activation R-HSA-203615 0.653535 0.185 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 0.653535 0.185 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 0.653535 0.185 0 0
Signaling by NOTCH2 R-HSA-1980145 0.653535 0.185 0 0
Mitophagy R-HSA-5205647 0.653535 0.185 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.653623 0.185 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.653623 0.185 0 0
Signaling by PTK6 R-HSA-8848021 0.655237 0.184 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.655237 0.184 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.657010 0.182 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 0.657114 0.182 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 0.657114 0.182 0 0
Long-term potentiation R-HSA-9620244 0.657114 0.182 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 0.657114 0.182 0 0
Tight junction interactions R-HSA-420029 0.657114 0.182 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 0.657114 0.182 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 0.664267 0.178 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 0.664267 0.178 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 0.664267 0.178 0 0
DAG1 core M1 glycosylations R-HSA-8932506 0.664267 0.178 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 0.664267 0.178 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 0.664267 0.178 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 0.664267 0.178 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 0.664267 0.178 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 0.664267 0.178 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 0.664267 0.178 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 0.664267 0.178 0 0
VLDL clearance R-HSA-8964046 0.664267 0.178 0 0
Regulation of PTEN localization R-HSA-8948747 0.664267 0.178 0 0
Netrin mediated repulsion signals R-HSA-418886 0.664267 0.178 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 0.664267 0.178 0 0
CHL1 interactions R-HSA-447041 0.664267 0.178 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 0.667333 0.176 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.667333 0.176 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 0.667333 0.176 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.667333 0.176 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 0.667333 0.176 0 0
tRNA modification in the mitochondrion R-HSA-6787450 0.667333 0.176 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 0.667333 0.176 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.667859 0.175 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.668718 0.175 0 0
Ion transport by P-type ATPases R-HSA-936837 0.669240 0.174 0 0
Cyclin D associated events in G1 R-HSA-69231 0.669305 0.174 0 0
G1 Phase R-HSA-69236 0.669305 0.174 0 0
Gap junction trafficking R-HSA-190828 0.669305 0.174 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 0.671791 0.173 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.674065 0.171 1 0
Selenocysteine synthesis R-HSA-2408557 0.676220 0.170 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.677857 0.169 0 0
TRP channels R-HSA-3295583 0.677857 0.169 0 0
Metalloprotease DUBs R-HSA-5689901 0.677857 0.169 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.685247 0.164 0 0
Fanconi Anemia Pathway R-HSA-6783310 0.685247 0.164 0 0
Somitogenesis R-HSA-9824272 0.685247 0.164 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.685247 0.164 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.685247 0.164 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.689371 0.162 0 0
PRC2 methylates histones and DNA R-HSA-212300 0.689371 0.162 0 0
RNA Polymerase III Transcription R-HSA-74158 0.689371 0.162 0 0
FLT3 signaling in disease R-HSA-9682385 0.689371 0.162 0 0
Triglyceride catabolism R-HSA-163560 0.689371 0.162 1 1
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.690922 0.161 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.690922 0.161 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 0.691859 0.160 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 0.691859 0.160 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 0.691859 0.160 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 0.691859 0.160 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 0.691859 0.160 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.691859 0.160 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 0.691859 0.160 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.697628 0.156 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.697628 0.156 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 0.697656 0.156 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.697656 0.156 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.697656 0.156 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.697656 0.156 0 0
Triglyceride biosynthesis R-HSA-75109 0.697656 0.156 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.697656 0.156 0 0
Viral mRNA Translation R-HSA-192823 0.697851 0.156 0 0
Type I hemidesmosome assembly R-HSA-446107 0.698993 0.156 0 0
RSK activation R-HSA-444257 0.698993 0.156 0 0
DAG1 core M2 glycosylations R-HSA-8932504 0.698993 0.156 0 0
phospho-PLA2 pathway R-HSA-111995 0.698993 0.156 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 0.698993 0.156 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 0.698993 0.156 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 0.698993 0.156 0 0
FGFR1b ligand binding and activation R-HSA-190370 0.698993 0.156 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 0.698993 0.156 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 0.698993 0.156 0 0
Interleukin-9 signaling R-HSA-8985947 0.698993 0.156 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 0.698993 0.156 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 0.698993 0.156 0 0
Regulation by c-FLIP R-HSA-3371378 0.698993 0.156 0 0
Fructose biosynthesis R-HSA-5652227 0.698993 0.156 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 0.698993 0.156 0 0
Dimerization of procaspase-8 R-HSA-69416 0.698993 0.156 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 0.698993 0.156 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 0.698993 0.156 0 0
Sodium/Proton exchangers R-HSA-425986 0.698993 0.156 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 0.698993 0.156 0 0
Modulation by Mtb of host immune system R-HSA-9637628 0.698993 0.156 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 0.698993 0.156 0 0
Signaling by TGFBR3 R-HSA-9839373 0.700660 0.154 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.701619 0.154 0 0
Degradation of AXIN R-HSA-4641257 0.706272 0.151 0 0
NCAM1 interactions R-HSA-419037 0.706272 0.151 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.707716 0.150 0 0
MAPK family signaling cascades R-HSA-5683057 0.708499 0.150 1 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 0.709086 0.149 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.712075 0.147 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.714873 0.146 0 0
FGFR1 ligand binding and activation R-HSA-190242 0.714873 0.146 0 0
GAB1 signalosome R-HSA-180292 0.714873 0.146 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.714873 0.146 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.714873 0.146 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.714873 0.146 0 0
Tie2 Signaling R-HSA-210993 0.714873 0.146 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 0.714873 0.146 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 0.714873 0.146 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.715543 0.145 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.715543 0.145 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.716517 0.145 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.716517 0.145 0 0
HIV elongation arrest and recovery R-HSA-167287 0.716517 0.145 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.716517 0.145 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 0.716517 0.145 0 0
Inflammasomes R-HSA-622312 0.716517 0.145 0 0
SLC transporter disorders R-HSA-5619102 0.718213 0.144 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.719862 0.143 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.719862 0.143 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 0.722494 0.141 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 0.722494 0.141 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 0.722494 0.141 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.722494 0.141 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.723330 0.141 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.728884 0.137 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.729120 0.137 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 0.730128 0.137 0 0
Lipophagy R-HSA-9613354 0.730128 0.137 0 0
CASP8 activity is inhibited R-HSA-5218900 0.730128 0.137 0 0
ALK mutants bind TKIs R-HSA-9700645 0.730128 0.137 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 0.730128 0.137 0 0
p75NTR regulates axonogenesis R-HSA-193697 0.730128 0.137 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 0.730128 0.137 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.730128 0.137 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 0.730128 0.137 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 0.730128 0.137 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 0.730128 0.137 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 0.730128 0.137 0 0
Cellular response to mitochondrial stress R-HSA-9840373 0.730128 0.137 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 0.730128 0.137 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 0.730128 0.137 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 0.730128 0.137 0 0
Sensory processing of sound R-HSA-9659379 0.731268 0.136 0 0
Gastrulation R-HSA-9758941 0.731690 0.136 0 0
mRNA Capping R-HSA-72086 0.734452 0.134 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 0.734452 0.134 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 0.734452 0.134 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.736425 0.133 0 0
E2F mediated regulation of DNA replication R-HSA-113510 0.736425 0.133 0 0
Diseases of hemostasis R-HSA-9671793 0.736425 0.133 0 0
Translesion Synthesis by POLH R-HSA-110320 0.736425 0.133 0 0
Other interleukin signaling R-HSA-449836 0.736425 0.133 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 0.736425 0.133 0 0
The NLRP3 inflammasome R-HSA-844456 0.736425 0.133 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.738042 0.132 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.738042 0.132 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.738042 0.132 0 0
Signaling by ALK R-HSA-201556 0.738042 0.132 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.738042 0.132 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.738363 0.132 0 0
Signaling by TGFB family members R-HSA-9006936 0.740800 0.130 0 0
Signaling by MET R-HSA-6806834 0.742462 0.129 0 0
Degradation of CDH1 R-HSA-9766229 0.743711 0.129 0 0
GABA receptor activation R-HSA-977443 0.750214 0.125 0 0
Kinesins R-HSA-983189 0.750214 0.125 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.751478 0.124 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 0.751478 0.124 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 0.751478 0.124 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.752922 0.123 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.752922 0.123 0 0
HIV Transcription Elongation R-HSA-167169 0.752922 0.123 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 0.752922 0.123 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.752922 0.123 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.752922 0.123 0 0
Diseases of Immune System R-HSA-5260271 0.752922 0.123 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.752922 0.123 0 0
Interleukin-2 family signaling R-HSA-451927 0.752922 0.123 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.752922 0.123 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.753328 0.123 0 0
Interleukin-1 family signaling R-HSA-446652 0.755800 0.122 0 0
Acyl chain remodelling of PI R-HSA-1482922 0.756571 0.121 0 0
Signaling by NODAL R-HSA-1181150 0.756571 0.121 0 0
Pregnenolone biosynthesis R-HSA-196108 0.756571 0.121 0 0
Signal transduction by L1 R-HSA-445144 0.756571 0.121 0 0
G alpha (s) signalling events R-HSA-418555 0.756854 0.121 1 0
Hedgehog 'on' state R-HSA-5632684 0.757018 0.121 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 0.758045 0.120 0 0
Binding and entry of HIV virion R-HSA-173107 0.758045 0.120 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 0.758045 0.120 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 0.758045 0.120 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 0.758045 0.120 0 0
Formation of intermediate mesoderm R-HSA-9761174 0.758045 0.120 0 0
Pexophagy R-HSA-9664873 0.758045 0.120 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 0.758045 0.120 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 0.758045 0.120 0 0
Tandem pore domain potassium channels R-HSA-1296346 0.758045 0.120 0 0
Josephin domain DUBs R-HSA-5689877 0.758045 0.120 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.762265 0.118 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.766104 0.116 0 0
Generic Transcription Pathway R-HSA-212436 0.766909 0.115 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.767142 0.115 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.767142 0.115 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 0.767616 0.115 0 0
Trafficking of AMPA receptors R-HSA-399719 0.767616 0.115 0 0
Budding and maturation of HIV virion R-HSA-162588 0.767616 0.115 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.767616 0.115 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.768065 0.115 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.768065 0.115 0 0
Meiotic recombination R-HSA-912446 0.769767 0.114 0 0
Ub-specific processing proteases R-HSA-5689880 0.771296 0.113 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.772942 0.112 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.773429 0.112 1 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.773880 0.111 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.773974 0.111 0 0
Leishmania infection R-HSA-9658195 0.774370 0.111 1 0
Parasitic Infection Pathways R-HSA-9824443 0.774370 0.111 1 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 0.775371 0.110 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.775371 0.110 0 0
Basigin interactions R-HSA-210991 0.775371 0.110 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.776983 0.110 0 0
Interleukin-1 signaling R-HSA-9020702 0.777255 0.109 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.778741 0.109 0 0
Intra-Golgi traffic R-HSA-6811438 0.780713 0.108 0 0
Orc1 removal from chromatin R-HSA-68949 0.782015 0.107 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.782015 0.107 0 0
DNA strand elongation R-HSA-69190 0.782888 0.106 0 0
G0 and Early G1 R-HSA-1538133 0.782888 0.106 0 0
DAG1 core M3 glycosylations R-HSA-8932505 0.783075 0.106 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 0.783075 0.106 0 0
vRNP Assembly R-HSA-192905 0.783075 0.106 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 0.783075 0.106 0 0
Chylomicron assembly R-HSA-8963888 0.783075 0.106 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 0.783075 0.106 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 0.783075 0.106 0 0
Suppression of apoptosis R-HSA-9635465 0.783075 0.106 0 0
Interleukin-2 signaling R-HSA-9020558 0.783075 0.106 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.783969 0.106 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.785065 0.105 0 0
Signaling by ERBB4 R-HSA-1236394 0.789048 0.103 0 0
HCMV Late Events R-HSA-9610379 0.792703 0.101 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.792888 0.101 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 0.792888 0.101 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.792888 0.101 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.792888 0.101 0 0
Glutathione synthesis and recycling R-HSA-174403 0.792888 0.101 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.793753 0.100 0 0
Insulin receptor signalling cascade R-HSA-74751 0.795825 0.099 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.795825 0.099 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 0.797321 0.098 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 0.797321 0.098 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.797321 0.098 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.797321 0.098 0 0
Chromosome Maintenance R-HSA-73886 0.797808 0.098 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.799590 0.097 0 0
Interferon Signaling R-HSA-913531 0.800936 0.096 0 0
PTEN Regulation R-HSA-6807070 0.801800 0.096 0 0
Gamma-carboxylation of protein precursors R-HSA-159740 0.805518 0.094 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 0.805518 0.094 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 0.805518 0.094 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 0.805518 0.094 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 0.805518 0.094 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 0.805518 0.094 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.805518 0.094 0 0
Activation of RAC1 R-HSA-428540 0.805518 0.094 0 0
ERKs are inactivated R-HSA-202670 0.805518 0.094 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 0.805518 0.094 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 0.805518 0.094 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 0.805518 0.094 0 0
Signaling by SCF-KIT R-HSA-1433557 0.805964 0.094 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.805964 0.094 0 0
Signaling by FGFR4 R-HSA-5654743 0.805964 0.094 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.809187 0.092 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 0.809187 0.092 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 0.809187 0.092 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.809187 0.092 0 0
Fructose metabolism R-HSA-5652084 0.809187 0.092 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.809187 0.092 0 0
Cellular hexose transport R-HSA-189200 0.809187 0.092 0 0
LDL clearance R-HSA-8964038 0.809187 0.092 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.809187 0.092 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 0.809187 0.092 0 0
Adipogenesis R-HSA-9843745 0.810669 0.091 0 0
Miscellaneous transport and binding events R-HSA-5223345 0.810942 0.091 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.815736 0.088 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.816640 0.088 0 0
Proteasome assembly R-HSA-9907900 0.817673 0.087 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.820694 0.086 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.823781 0.084 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 0.824331 0.084 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 0.824331 0.084 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.824331 0.084 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.824331 0.084 0 0
Syndecan interactions R-HSA-3000170 0.824331 0.084 0 0
Scavenging by Class F Receptors R-HSA-3000484 0.825639 0.083 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 0.825639 0.083 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 0.825639 0.083 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 0.825639 0.083 0 0
IRAK1 recruits IKK complex R-HSA-937039 0.825639 0.083 0 0
VLDLR internalisation and degradation R-HSA-8866427 0.825639 0.083 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 0.825639 0.083 0 0
Regulation of IFNG signaling R-HSA-877312 0.825639 0.083 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.826002 0.083 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.828795 0.082 0 0
Signaling by FGFR3 R-HSA-5654741 0.828795 0.082 0 0
Synthesis of DNA R-HSA-69239 0.834115 0.079 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.834740 0.078 0 0
IRS-mediated signalling R-HSA-112399 0.835799 0.078 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.835866 0.078 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 0.835866 0.078 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 0.835984 0.078 1 0
Leishmania parasite growth and survival R-HSA-9664433 0.835984 0.078 1 0
ER-Phagosome pathway R-HSA-1236974 0.836650 0.077 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 0.838385 0.077 0 0
Complex III assembly R-HSA-9865881 0.838385 0.077 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 0.838385 0.077 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 0.838385 0.077 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 0.838385 0.077 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 0.839347 0.076 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 0.839347 0.076 0 0
Adenylate cyclase activating pathway R-HSA-170660 0.843680 0.074 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 0.843680 0.074 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 0.843680 0.074 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.843680 0.074 0 0
Chylomicron remodeling R-HSA-8963901 0.843680 0.074 0 0
FGFR1c ligand binding and activation R-HSA-190373 0.843680 0.074 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 0.843680 0.074 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 0.843680 0.074 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 0.843680 0.074 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 0.843680 0.074 0 0
Mitochondrial biogenesis R-HSA-1592230 0.844027 0.074 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.845139 0.073 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.845139 0.073 0 0
GPVI-mediated activation cascade R-HSA-114604 0.847230 0.072 0 0
FGFR2 mutant receptor activation R-HSA-1839126 0.847230 0.072 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.848790 0.071 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.849348 0.071 0 0
Synthesis of PC R-HSA-1483191 0.849348 0.071 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 0.851413 0.070 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 0.851413 0.070 0 0
Laminin interactions R-HSA-3000157 0.851413 0.070 0 0
Hyaluronan degradation R-HSA-2160916 0.851413 0.070 0 0
COPII-mediated vesicle transport R-HSA-204005 0.851835 0.070 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.854036 0.069 0 0
Degradation of DVL R-HSA-4641258 0.857904 0.067 0 0
SLC-mediated transport of organic cations R-HSA-549127 0.857904 0.067 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.859825 0.066 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.859825 0.066 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 0.859855 0.066 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 0.859855 0.066 0 0
CRMPs in Sema3A signaling R-HSA-399956 0.859855 0.066 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 0.859855 0.066 0 0
Hydrolysis of LPC R-HSA-1483115 0.859855 0.066 0 0
Retrograde neurotrophin signalling R-HSA-177504 0.859855 0.066 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 0.859855 0.066 0 0
NRIF signals cell death from the nucleus R-HSA-205043 0.859855 0.066 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 0.859855 0.066 0 0
Malate-aspartate shuttle R-HSA-9856872 0.859855 0.066 0 0
Signaling by FGFR4 in disease R-HSA-5655291 0.859855 0.066 0 0
Ciprofloxacin ADME R-HSA-9793528 0.859855 0.066 0 0
Acyl chain remodeling of CL R-HSA-1482798 0.859855 0.066 0 0
Zinc transporters R-HSA-435354 0.859855 0.066 0 0
Neutrophil degranulation R-HSA-6798695 0.860048 0.065 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.862503 0.064 0 0
MET activates PTK2 signaling R-HSA-8874081 0.863477 0.064 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.863477 0.064 0 0
Abacavir ADME R-HSA-2161522 0.863477 0.064 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 0.863477 0.064 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 0.863477 0.064 0 0
Translation R-HSA-72766 0.865644 0.063 0 0
MET promotes cell motility R-HSA-8875878 0.867918 0.062 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.867918 0.062 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.870554 0.060 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 0.874358 0.058 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 0.874358 0.058 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 0.874358 0.058 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 0.874358 0.058 0 0
Protein lipoylation R-HSA-9857492 0.874358 0.058 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.874358 0.058 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.874358 0.058 0 0
Biotin transport and metabolism R-HSA-196780 0.874358 0.058 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 0.874358 0.058 0 0
Processive synthesis on the lagging strand R-HSA-69183 0.874358 0.058 0 0
Spry regulation of FGF signaling R-HSA-1295596 0.874358 0.058 0 0
Cristae formation R-HSA-8949613 0.874635 0.058 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.874635 0.058 0 0
Synthesis of PE R-HSA-1483213 0.874635 0.058 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 0.874635 0.058 0 0
Toll-like Receptor Cascades R-HSA-168898 0.875265 0.058 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.876235 0.057 0 0
PI3K Cascade R-HSA-109704 0.876235 0.057 0 0
Signaling by FGFR2 in disease R-HSA-5655253 0.876235 0.057 0 0
Stabilization of p53 R-HSA-69541 0.877304 0.057 0 0
Mitochondrial protein import R-HSA-1268020 0.878202 0.056 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.878202 0.056 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.878661 0.056 0 0
MHC class II antigen presentation R-HSA-2132295 0.880034 0.056 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.884225 0.053 0 0
The phototransduction cascade R-HSA-2514856 0.884225 0.053 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.884948 0.053 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.885462 0.053 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.886093 0.053 0 0
Killing mechanisms R-HSA-9664420 0.887360 0.052 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.887360 0.052 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.887360 0.052 0 0
Phase 4 - resting membrane potential R-HSA-5576886 0.887360 0.052 0 0
Activation of SMO R-HSA-5635838 0.887360 0.052 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 0.887360 0.052 0 0
Activation of the phototransduction cascade R-HSA-2485179 0.887360 0.052 0 0
Fructose catabolism R-HSA-70350 0.887360 0.052 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.887360 0.052 0 0
Attachment and Entry R-HSA-9678110 0.887360 0.052 0 0
Negative regulation of FLT3 R-HSA-9706369 0.887360 0.052 0 0
DNA Replication R-HSA-69306 0.889206 0.051 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.891970 0.050 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.892622 0.049 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.894314 0.049 0 0
FLT3 Signaling R-HSA-9607240 0.894314 0.049 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 0.894469 0.048 0 0
Termination of translesion DNA synthesis R-HSA-5656169 0.894469 0.048 0 0
Platelet calcium homeostasis R-HSA-418360 0.894469 0.048 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.894469 0.048 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.895338 0.048 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.895338 0.048 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.895338 0.048 0 0
G1/S Transition R-HSA-69206 0.895338 0.048 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.895949 0.048 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.898864 0.046 0 0
Cellular response to hypoxia R-HSA-1234174 0.898872 0.046 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 0.899017 0.046 0 0
Glycine degradation R-HSA-6783984 0.899017 0.046 0 0
Passive transport by Aquaporins R-HSA-432047 0.899017 0.046 0 0
Galactose catabolism R-HSA-70370 0.899017 0.046 0 0
Coenzyme A biosynthesis R-HSA-196783 0.899017 0.046 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 0.899017 0.046 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 0.899017 0.046 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.900589 0.045 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.901999 0.045 0 0
Scavenging by Class A Receptors R-HSA-3000480 0.901999 0.045 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.901999 0.045 0 0
Translation of Structural Proteins R-HSA-9683701 0.901999 0.045 0 0
DAP12 signaling R-HSA-2424491 0.903252 0.044 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.905267 0.043 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 0.909469 0.041 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 0.909469 0.041 0 0
GDP-fucose biosynthesis R-HSA-6787639 0.909469 0.041 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 0.909469 0.041 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 0.909469 0.041 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.911349 0.040 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.911349 0.040 0 0
Cargo concentration in the ER R-HSA-5694530 0.911349 0.040 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 0.911349 0.040 0 0
Paracetamol ADME R-HSA-9753281 0.911846 0.040 0 0
Downstream TCR signaling R-HSA-202424 0.913534 0.039 0 0
TCR signaling R-HSA-202403 0.914469 0.039 0 0
Regulated Necrosis R-HSA-5218859 0.916427 0.038 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.916841 0.038 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.917763 0.037 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.918307 0.037 0 0
DAG1 glycosylations R-HSA-8931838 0.918807 0.037 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.918807 0.037 0 0
Transport of connexons to the plasma membrane R-HSA-190872 0.918839 0.037 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 0.918839 0.037 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.918839 0.037 0 0
Synaptic adhesion-like molecules R-HSA-8849932 0.918839 0.037 0 0
Apoptotic factor-mediated response R-HSA-111471 0.918839 0.037 0 0
Polo-like kinase mediated events R-HSA-156711 0.918839 0.037 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.921651 0.035 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.921713 0.035 1 0
Synthesis of PA R-HSA-1483166 0.923322 0.035 0 0
Cardiogenesis R-HSA-9733709 0.925671 0.034 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 0.926584 0.033 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.926584 0.033 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 0.927241 0.033 0 0
Regulation of signaling by CBL R-HSA-912631 0.927241 0.033 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 0.927241 0.033 0 0
Specification of the neural plate border R-HSA-9834899 0.927241 0.033 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 0.927241 0.033 0 0
HDL remodeling R-HSA-8964058 0.927241 0.033 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.927931 0.032 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.929284 0.032 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.930727 0.031 0 0
SARS-CoV Infections R-HSA-9679506 0.930944 0.031 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.931239 0.031 0 0
ECM proteoglycans R-HSA-3000178 0.931239 0.031 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.931281 0.031 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.931863 0.031 0 0
Acyl chain remodelling of PC R-HSA-1482788 0.931985 0.031 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.931985 0.031 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.931985 0.031 0 0
Heme degradation R-HSA-189483 0.931985 0.031 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 0.934772 0.029 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.934772 0.029 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.934772 0.029 0 0
Nephrin family interactions R-HSA-373753 0.934772 0.029 0 0
Collagen formation R-HSA-1474290 0.935186 0.029 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.937788 0.028 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.937788 0.028 0 0
Hyaluronan metabolism R-HSA-2142845 0.937788 0.028 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.937788 0.028 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.937788 0.028 0 0
Calnexin/calreticulin cycle R-HSA-901042 0.937788 0.028 0 0
Developmental Biology R-HSA-1266738 0.940598 0.027 1 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 0.941525 0.026 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.941525 0.026 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 0.941525 0.026 0 0
Acyl chain remodelling of PG R-HSA-1482925 0.941525 0.026 0 0
Lagging Strand Synthesis R-HSA-69186 0.941525 0.026 0 0
Collagen degradation R-HSA-1442490 0.942328 0.026 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.942461 0.026 1 1
Acyl chain remodelling of PE R-HSA-1482839 0.943120 0.025 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.943120 0.025 0 0
Regulation of Apoptosis R-HSA-169911 0.943120 0.025 0 0
Potassium Channels R-HSA-1296071 0.945750 0.024 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.947327 0.024 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.947417 0.023 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.947417 0.023 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.947417 0.023 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 0.947579 0.023 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.947579 0.023 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 0.947579 0.023 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 0.947579 0.023 0 0
Assembly Of The HIV Virion R-HSA-175474 0.947579 0.023 0 0
Attachment and Entry R-HSA-9694614 0.947579 0.023 0 0
Ribavirin ADME R-HSA-9755088 0.947579 0.023 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.948014 0.023 0 0
G1/S-Specific Transcription R-HSA-69205 0.948014 0.023 0 0
Telomere Maintenance R-HSA-157579 0.948914 0.023 0 0
Cellular response to chemical stress R-HSA-9711123 0.951626 0.022 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.951913 0.021 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.952506 0.021 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 0.952506 0.021 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.952506 0.021 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 0.953006 0.021 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 0.953006 0.021 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 0.953006 0.021 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 0.953006 0.021 0 0
Ethanol oxidation R-HSA-71384 0.953006 0.021 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 0.953006 0.021 0 0
Translation of Structural Proteins R-HSA-9694635 0.954019 0.020 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.954550 0.020 0 0
Leishmania phagocytosis R-HSA-9664417 0.954550 0.020 0 0
Parasite infection R-HSA-9664407 0.954550 0.020 0 0
Biofilm formation R-HSA-9931953 0.956625 0.019 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.956856 0.019 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 0.956937 0.019 0 0
ABC transporter disorders R-HSA-5619084 0.957066 0.019 0 0
Integrin cell surface interactions R-HSA-216083 0.957066 0.019 0 0
ABC-family proteins mediated transport R-HSA-382556 0.957441 0.019 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.957579 0.019 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 0.957872 0.019 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 0.957872 0.019 0 0
Carnitine shuttle R-HSA-200425 0.957872 0.019 0 0
Formation of the ureteric bud R-HSA-9830674 0.957872 0.019 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 0.958237 0.019 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.958681 0.018 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.958681 0.018 0 0
Signaling by Interleukins R-HSA-449147 0.959049 0.018 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.960012 0.018 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 0.960400 0.018 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.960400 0.018 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.961903 0.017 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.962035 0.017 0 0
Mitochondrial RNA degradation R-HSA-9836573 0.962234 0.017 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 0.962234 0.017 0 0
TNFs bind their physiological receptors R-HSA-5669034 0.962234 0.017 0 0
PI Metabolism R-HSA-1483255 0.962390 0.017 0 0
G alpha (q) signalling events R-HSA-416476 0.963110 0.016 0 0
Glycogen metabolism R-HSA-8982491 0.963859 0.016 0 0
Generation of second messenger molecules R-HSA-202433 0.963859 0.016 0 0
Signaling by Insulin receptor R-HSA-74752 0.965682 0.015 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 0.966145 0.015 0 0
Alpha-oxidation of phytanate R-HSA-389599 0.966145 0.015 0 0
Retinoid cycle disease events R-HSA-2453864 0.966145 0.015 0 0
Diseases of the neuronal system R-HSA-9675143 0.966145 0.015 0 0
Diseases associated with visual transduction R-HSA-2474795 0.966145 0.015 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 0.967027 0.015 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.967027 0.015 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.967027 0.015 0 0
Maturation of spike protein R-HSA-9694548 0.967027 0.015 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.967337 0.014 0 0
HDACs deacetylate histones R-HSA-3214815 0.967650 0.014 0 0
RSV-host interactions R-HSA-9833110 0.968840 0.014 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 0.969651 0.013 0 0
Urea cycle R-HSA-70635 0.969651 0.013 0 0
Sphingolipid catabolism R-HSA-9845614 0.969651 0.013 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 0.969651 0.013 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 0.969651 0.013 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 0.969926 0.013 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.969926 0.013 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.969926 0.013 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.970025 0.013 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 0.970207 0.013 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.971635 0.012 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.972555 0.012 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.972579 0.012 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 0.972579 0.012 0 0
Packaging Of Telomere Ends R-HSA-171306 0.972794 0.012 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 0.972794 0.012 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 0.972794 0.012 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 0.972794 0.012 0 0
Signaling by BMP R-HSA-201451 0.972794 0.012 0 0
Signaling by FGFR3 in disease R-HSA-5655332 0.972794 0.012 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.974175 0.011 0 0
Dual incision in TC-NER R-HSA-6782135 0.974757 0.011 0 0
Potential therapeutics for SARS R-HSA-9679191 0.974797 0.011 0 0
Defective pyroptosis R-HSA-9710421 0.975005 0.011 0 0
Telomere Extension By Telomerase R-HSA-171319 0.975612 0.011 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.975612 0.011 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 0.975612 0.011 0 0
Prednisone ADME R-HSA-9757110 0.975612 0.011 0 0
Pyrimidine salvage R-HSA-73614 0.975612 0.011 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 0.975612 0.011 0 0
Pyroptosis R-HSA-5620971 0.975612 0.011 0 0
Stimuli-sensing channels R-HSA-2672351 0.975871 0.011 0 0
Extension of Telomeres R-HSA-180786 0.976777 0.010 0 0
DAP12 interactions R-HSA-2172127 0.977222 0.010 0 0
Netrin-1 signaling R-HSA-373752 0.977222 0.010 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.977222 0.010 0 0
Surfactant metabolism R-HSA-5683826 0.977222 0.010 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.977234 0.010 0 0
Selenoamino acid metabolism R-HSA-2408522 0.977625 0.010 0 0
DNA methylation R-HSA-5334118 0.978138 0.010 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 0.978138 0.010 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 0.978138 0.010 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 0.978138 0.010 0 0
Pyruvate metabolism R-HSA-70268 0.978822 0.009 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.979825 0.009 0 0
FOXO-mediated transcription R-HSA-9614085 0.979989 0.009 0 0
Ion channel transport R-HSA-983712 0.980453 0.009 0 0
Regulation of pyruvate metabolism R-HSA-9861718 0.981101 0.008 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.981101 0.008 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.981101 0.008 0 0
Interleukin-12 signaling R-HSA-9020591 0.981335 0.008 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.981953 0.008 0 0
Aspartate and asparagine metabolism R-HSA-8963693 0.982433 0.008 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.982691 0.008 0 0
RNA Polymerase I Transcription R-HSA-73864 0.984040 0.007 0 0
Interleukin-10 signaling R-HSA-6783783 0.984040 0.007 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 0.984253 0.007 0 0
Intraflagellar transport R-HSA-5620924 0.984335 0.007 0 0
Plasma lipoprotein remodeling R-HSA-8963899 0.984335 0.007 0 0
Metal ion SLC transporters R-HSA-425410 0.984335 0.007 0 0
Viral Infection Pathways R-HSA-9824446 0.984628 0.007 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.984768 0.007 0 0
Developmental Cell Lineages R-HSA-9734767 0.985489 0.006 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 0.985743 0.006 0 0
Chemokine receptors bind chemokines R-HSA-380108 0.985743 0.006 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.985754 0.006 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.985884 0.006 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 0.985884 0.006 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.986371 0.006 0 0
Platelet degranulation R-HSA-114608 0.986789 0.006 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.987347 0.006 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 0.987347 0.006 0 0
Complex IV assembly R-HSA-9864848 0.988199 0.005 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.988199 0.005 0 0
Nicotinate metabolism R-HSA-196807 0.988218 0.005 0 0
Dual Incision in GG-NER R-HSA-5696400 0.988658 0.005 0 0
Gap junction assembly R-HSA-190861 0.988658 0.005 0 0
RA biosynthesis pathway R-HSA-5365859 0.988658 0.005 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 0.988658 0.005 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 0.988658 0.005 0 0
Oncogene Induced Senescence R-HSA-2559585 0.989833 0.004 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 0.989833 0.004 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 0.989833 0.004 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 0.989833 0.004 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.990230 0.004 0 0
Nucleotide biosynthesis R-HSA-8956320 0.990241 0.004 0 0
Phospholipid metabolism R-HSA-1483257 0.990608 0.004 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.990775 0.004 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.990887 0.004 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.990887 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 0.990909 0.004 0 0
G alpha (i) signalling events R-HSA-418594 0.991061 0.004 1 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.991129 0.004 0 0
Metabolism of cofactors R-HSA-8978934 0.991666 0.004 0 0
Voltage gated Potassium channels R-HSA-1296072 0.991831 0.004 0 0
Cleavage of the damaged purine R-HSA-110331 0.991831 0.004 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 0.991831 0.004 0 0
Metabolism of folate and pterines R-HSA-196757 0.991831 0.004 0 0
Transmission across Chemical Synapses R-HSA-112315 0.992646 0.003 1 0
Depurination R-HSA-73927 0.992678 0.003 0 0
Interleukin-12 family signaling R-HSA-447115 0.992836 0.003 0 0
Neuronal System R-HSA-112316 0.993032 0.003 1 0
Adaptive Immune System R-HSA-1280218 0.993112 0.003 1 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.993343 0.003 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 0.993437 0.003 0 0
Neddylation R-HSA-8951664 0.993727 0.003 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.994117 0.003 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.994117 0.003 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.994117 0.003 0 0
Tryptophan catabolism R-HSA-71240 0.994117 0.003 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 0.994117 0.003 0 0
Hemostasis R-HSA-109582 0.994427 0.002 1 0
Peroxisomal protein import R-HSA-9033241 0.994508 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 0.994508 0.002 0 0
Co-inhibition by PD-1 R-HSA-389948 0.994530 0.002 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.994625 0.002 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 0.994727 0.002 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.994727 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 0.994727 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 0.994870 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 0.995013 0.002 0 0
Glutathione conjugation R-HSA-156590 0.995013 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 0.995013 0.002 0 0
Metabolism of polyamines R-HSA-351202 0.995013 0.002 0 0
tRNA Aminoacylation R-HSA-379724 0.995013 0.002 0 0
Heme biosynthesis R-HSA-189451 0.995273 0.002 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.995763 0.002 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 0.995763 0.002 0 0
Depyrimidination R-HSA-73928 0.995763 0.002 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 0.995763 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 0.995880 0.002 0 0
Response of Mtb to phagocytosis R-HSA-9637690 0.996203 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.996563 0.001 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 0.996949 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.997118 0.001 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 0.997266 0.001 0 0
GPCR downstream signalling R-HSA-388396 0.997336 0.001 1 0
SLC-mediated transport of amino acids R-HSA-9958863 0.997473 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 0.997473 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 0.997519 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 0.997766 0.001 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.997801 0.001 0 0
Gluconeogenesis R-HSA-70263 0.997803 0.001 0 0
Post-translational protein modification R-HSA-597592 0.997958 0.001 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.998048 0.001 0 0
Protein localization R-HSA-9609507 0.998183 0.001 0 0
Azathioprine ADME R-HSA-9748787 0.998235 0.001 0 0
Metabolism of porphyrins R-HSA-189445 0.998292 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 0.998343 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 0.998418 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 0.998452 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.998800 0.001 0 0
Interferon gamma signaling R-HSA-877300 0.998823 0.001 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 0.998861 0.000 0 0
Digestion R-HSA-8935690 0.999085 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 0.999117 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 0.999144 0.000 0 0
Dectin-2 family R-HSA-5621480 0.999180 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 0.999204 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 0.999208 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.999331 0.000 0 0
Nucleotide salvage R-HSA-8956321 0.999471 0.000 0 0
Complex I biogenesis R-HSA-6799198 0.999575 0.000 0 0
Digestion and absorption R-HSA-8963743 0.999575 0.000 0 0
Extracellular matrix organization R-HSA-1474244 0.999608 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 0.999619 0.000 0 0
Visual phototransduction R-HSA-2187338 0.999692 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 0.999711 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.999722 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 0.999726 0.000 0 0
Kidney development R-HSA-9830369 0.999726 0.000 0 0
Base Excision Repair R-HSA-73884 0.999766 0.000 0 0
Neurotransmitter release cycle R-HSA-112310 0.999766 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 0.999823 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 0.999823 0.000 0 0
Signaling by GPCR R-HSA-372790 0.999834 0.000 1 0
PPARA activates gene expression R-HSA-1989781 0.999841 0.000 0 0
Purine catabolism R-HSA-74259 0.999842 0.000 0 0
FCGR activation R-HSA-2029481 0.999844 0.000 0 0
Aspirin ADME R-HSA-9749641 0.999858 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.999865 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 0.999873 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 0.999873 0.000 0 0
Iron uptake and transport R-HSA-917937 0.999886 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 0.999896 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 0.999915 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.999916 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 0.999918 0.000 0 0
Respiratory electron transport R-HSA-611105 0.999920 0.000 0 0
Infectious disease R-HSA-5663205 0.999929 0.000 1 0
Metabolism of fat-soluble vitamins R-HSA-6806667 0.999941 0.000 0 0
Amyloid fiber formation R-HSA-977225 0.999941 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.999949 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 0.999956 0.000 1 0
Peroxisomal lipid metabolism R-HSA-390918 0.999958 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 0.999975 0.000 0 0
Metabolism of steroids R-HSA-8957322 0.999978 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 0.999985 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 0.999988 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 0.999990 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 0.999991 0.000 0 0
Disease R-HSA-1643685 0.999992 0.000 1 0
Cell surface interactions at the vascular wall R-HSA-202733 0.999992 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 0.999994 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 0.999995 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.999996 0.000 0 0
Sphingolipid metabolism R-HSA-428157 0.999997 0.000 0 0
Drug ADME R-HSA-9748784 0.999997 0.000 0 0
Nucleotide catabolism R-HSA-8956319 0.999998 0.000 0 0
Sensory perception of taste R-HSA-9717189 0.999998 0.000 0 0
Metabolism of proteins R-HSA-392499 0.999999 0.000 0 0
Antimicrobial peptides R-HSA-6803157 0.999999 0.000 0 0
Innate Immune System R-HSA-168249 0.999999 0.000 1 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 0.999999 0.000 0 0
O-linked glycosylation R-HSA-5173105 0.999999 0.000 0 0
Mitochondrial translation R-HSA-5368287 0.999999 0.000 0 0
Metabolism of nucleotides R-HSA-15869 0.999999 0.000 0 0
Immune System R-HSA-168256 1.000000 0.000 1 0
Keratinization R-HSA-6805567 1.000000 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000 0.000 1 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 -0.000 1 0
Metabolism R-HSA-1430728 1.000000 -0.000 1 0
Diseases of metabolism R-HSA-5668914 1.000000 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways