MSK1

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0MZ66	T487	Sugiyama	SHTN1 KIAA1598	sLDPENsEtELERILRRRKVtAEADsssPtGILAtsEsKsM
A1L170	S258	Sugiyama	C1orf226	PIsLAEsWEDGsPPPQARtssLDNEGPHPDLLsFE______
A4FU28	S140	Sugiyama	CTAGE9	AAAEEARSLEATCEKLSRsNsELEDEILCLEKDLKEEKSKH
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0	S939	Sugiyama	POTEF A26C1B	VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
O00273	S28	Sugiyama	DFFA DFF1 DFF45 H13	GVPESGEIRTLKPCLLRRNysREQHGVAAsCLEDLRSKACD
O00512	S104	Sugiyama	BCL9	GLKNGAGNGAKGKGKRERsIsADsFDQRDPGtPNDDsDIKE
O14579	S99	Sugiyama	COPE	PELQAVRMFADyLAHEsRRDsIVAELDREMsRSVDVTNTTF
O14617	S658	Sugiyama	AP3D1 PRO0039	DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14618	S267	Sugiyama	CCS	DGLTIWEERGRPIAGKGRKEsAQPPAHL_____________
O14974	S894	Sugiyama	PPP1R12A MBS MYPT1	EEGsNKKEtQtDsIsRyETssTsAGDRyDsLLGRsGsysYL
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14974	S995	Sugiyama	PPP1R12A MBS MYPT1	ADRSLLEMEKRERRALERRIsEMEEELKMLPDLKADNQRLK
O14974	T696	Sugiyama	PPP1R12A MBS MYPT1	EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O14980	S1055	Sugiyama	XPO1 CRM1	LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15067	S215	Sugiyama	PFAS KIAA0361	LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15357	S1176	Sugiyama	INPPL1 SHIP2	RGLPsDyGRPLsFPPPRIREsIQEDLAEEAPCLQGGRASGL
O15372	S290	Sugiyama	EIF3H EIF3S3	QQQQKHQYQQRRQQENMQRQsRGEPPLPEEDLsKLFKPPQP
O15446	T433	Sugiyama	POLR1G ASE1 CAST CD3EAP PAF49	EPQAAPtstKKKKKKKERGHtVtEPIQPLEPELPGEGQPEA
O43615	S180	Sugiyama	TIMM44 MIMT44 TIM44	AESVSKGGEKLGRTAAFRALsQGVEsVKKEIDDsVLGQtGP
O43823	S323	Sugiyama	AKAP8 AKAP95	RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43847	S94	Sugiyama	NRDC NRD1	ENSRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYR
O43852	S44	Sugiyama	CALU	KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O60279	S70	Sugiyama	SUSD5 KIAA0527	QGLQLEAARLSCKSRGAHLAsADELRRVVQDCSFAVCTTGW
O60293	S42	Sugiyama	ZFC3H1 CCDC131 KIAA0546 PSRC2	LEDGEIsDDDNNSQIRSRsssSsSGGGLLPYPRRRPPHSAR
O60343	S486	Sugiyama	TBC1D4 AS160 KIAA0603	ERIEGLYPPRAKLVIQRHLssLtDNEQADIFERVQKMKPVS
O60343	S588	Sugiyama	TBC1D4 AS160 KIAA0603	tssLENIFSRGANRMRGRLGsVDsFERsNsLASEKDYsPGD
O60343	S751	Sugiyama	TBC1D4 AS160 KIAA0603	EIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRIS
O60664	S93	Sugiyama	PLIN3 M6PRBP1 TIP47	AAVsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQP
O60664	Y95	Sugiyama	PLIN3 M6PRBP1 TIP47	VsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQPTE
O60814	S37	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60814	S39	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841	S183	Sugiyama	EIF5B IF2 KIAA0741	GsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKN
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60927	S74	Sugiyama	PPP1R11 HCGV TCTE5	GRRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGH
O75122	S616	Sugiyama	CLASP2 KIAA0627	sDVEEAVADALKKPARRRyEsYGMHsDDDANSDASSACSER
O75128	S962	Sugiyama	COBL KIAA0633	EDLAVGAPPRGEVIGPHRKLstQDRPAAIHRssCFSLVQSS
O75348	S68	Sugiyama	ATP6V1G1 ATP6G ATP6G1 ATP6J	RLQREKEFKAKEAAALGsRGsCstEVEKETQEKMTILQtyF
O75369	S1442	Sugiyama	FLNB FLN1L FLN3 TABP TAP	SKVKIAGPGLGsGVRARVLQsFtVDSSKAGLAPLEVRVLGP
O75400	T948	Sugiyama	PRPF40A FBP11 FLAF1 FNBP3 HIP10 HYPA HSPC225	GNWDtsGsELsEGELEKRRRtLLEQLDDDQ___________
O75534	T582	Sugiyama	CSDE1 D1S155E KIAA0885 NRU UNR	VEYSLSKGKGNKVSAEKVNKtHsVNGItEEADPTIysGKVI
O75582	S212	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	RPS6KA5 MSK1	VLTDFGLSKEFVADETERAYsFCGtIEYMAPDIVRGGDSGH
O75582	S376	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	RPS6KA5 MSK1	DPtYsPAALPQssEKLFQGYsFVAPsILFKRNAAVIDPLQF
O75582	S381	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	RPS6KA5 MSK1	PAALPQssEKLFQGYsFVAPsILFKRNAAVIDPLQFHMGVE
O75582	S436	Sugiyama	RPS6KA5 MSK1	DSPFYQHYDLDLKDKPLGEGsFSICRKCVHKKSNQAFAVKI
O75582	S517	Sugiyama	RPS6KA5 MSK1	VMELLNGGELFERIKKKKHFsETEASYIMRKLVSAVSHMHD
O75582	S633	Sugiyama	RPS6KA5 MSK1	YTMLSGQVPFQSHDRsLtCTsAVEIMKKIKKGDFsFEGEAW
O75582	S647	Sugiyama	RPS6KA5 MSK1	RsLtCTsAVEIMKKIKKGDFsFEGEAWKNVSQEAKDLIQGL
O75582	S750	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	RPS6KA5 MSK1	FCLQNVDKAPLAKRRKMKKTsTsTETRssssESSHSSSsHS
O75582	S752	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	RPS6KA5 MSK1	LQNVDKAPLAKRRKMKKTsTsTETRssssESSHSSSsHSHG
O75582	S758	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	RPS6KA5 MSK1	APLAKRRKMKKTsTsTETRssssESSHSSSsHSHGKTTPTK
O75582	S788	Sugiyama	RPS6KA5 MSK1	sHSHGKTTPTKTLQPSNPADsNNPEtLFQFSDsVA______
O75582	S800	Sugiyama	RPS6KA5 MSK1	LQPSNPADsNNPEtLFQFSDsVA__________________
O75582	T216	Sugiyama	RPS6KA5 MSK1	FGLSKEFVADETERAYsFCGtIEYMAPDIVRGGDSGHDKAV
O75582	T34	Sugiyama	RPS6KA5 MSK1	tsADGGDGGEQLLTVKHELRtANLtGHAEKVGIENFELLKV
O75582	T38	Sugiyama	RPS6KA5 MSK1	GGDGGEQLLTVKHELRtANLtGHAEKVGIENFELLKVLGTG
O75582	T630	Sugiyama	RPS6KA5 MSK1	VILYTMLSGQVPFQSHDRsLtCTsAVEIMKKIKKGDFsFEG
O75582	T718	Sugiyama	RPS6KA5 MSK1	LMtPDILGSSGAAVHTCVKAtFHAFNKYKREGFCLQNVDKA
O75665	S899	Sugiyama	OFD1 CXorf5	EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O75821	S189	Sugiyama	EIF3G EIF3S4	CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O76021	S314	Sugiyama	RSL1D1 CATX11 CSIG PBK1 L12	RNFEKQKERKKKRQQARKtAsVLsKDDVAPEsGDtTVKKPE
O76021	S317	Sugiyama	RSL1D1 CATX11 CSIG PBK1 L12	EKQKERKKKRQQARKtAsVLsKDDVAPEsGDtTVKKPESKK
O94761	S27	Sugiyama	RECQL4 RECQ4	VRERLQAWERAFRRQRGRRPsQDDVEAAPEETRALYREYRT
O94888	S280	Sugiyama	UBXN7 KIAA0794 UBXD7	EHGQLDGLsssPPKKCARsEsLIDAsEDsQLEAAIRASLQE
O94992	S268	Sugiyama	HEXIM1 CLP1 EDG1 HIS1 MAQ1	EDGGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELI
O94992	T270	Sugiyama	HEXIM1 CLP1 EDG1 HIS1 MAQ1	GGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELIKE
O95155	S105	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95155	S79	Sugiyama	UBE4B HDNB1 KIAA0684 UFD2	NMtPAtsPIGASGVAHRsQssEGVssLsssPsNsLEtQsQs
O95602	T1373	Sugiyama	POLR1A	SIKKKNNKASAFRNVNTRRAtQRDLDNAGELGRSRGEQEGD
O95678	S162	Sugiyama	KRT75 K6HF KB18	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O95714	S2928	Sugiyama	HERC2	ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
O95757	S586	Sugiyama	HSPA4L APG1 HSPH3 OSP94	DRLNQTLKKGKVKsIDLPIQssLCRQLGQDLLNsyIENEGK
P00491	S176	Sugiyama	PNP NP	GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00558	S399	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558	T394	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P02538	S176	Sugiyama	KRT6A K6A KRT6D	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P02545	S458	Sugiyama	LMNA LMN1	GRVAVEEVDEEGKFVRLRNKsNEDQsMGNWQIKRQNGDDPL
P04040	S254	Sugiyama	CAT	FHYKTDQGIKNLSVEDAARLsQEDPDYGIRDLFNAIATGKY
P04040	T434	Sugiyama	CAT	QQPSALEHSIQYSGEVRRFNtANDDNVtQVRAFyVNVLNEE
P04075	S336	Sugiyama	ALDOA ALDA	GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075	S36	Sugiyama	ALDOA ALDA	LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075	T37	Sugiyama	ALDOA ALDA	sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04259	S176	Sugiyama	KRT6B K6B KRTL1	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406	S312	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	sstFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMA
P04406	T237	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792	S78	Sugiyama	HSPB1 HSP27 HSP28	LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05114	S21	GPS6\|EPSD	HMGN1 HMG14	MPKRKVssAEGAAKEEPKRRsARLsAKPPAKVEAKPKKAAA
P05114	S25	GPS6\|EPSD	HMGN1 HMG14	KVssAEGAAKEEPKRRsARLsAKPPAKVEAKPKKAAAKDKS
P05114	S7	SIGNOR\|iPTMNet\|EPSD	HMGN1 HMG14	______________MPKRKVssAEGAAKEEPKRRsARLsAK
P05362	S43	Sugiyama	ICAM1	GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05386	S104	Sugiyama	RPLP1 RRP1	tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387	S105	Sugiyama	RPLP2 D11S2243E RPP2	GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05387	S29	Sugiyama	RPLP2 D11S2243E RPP2	LAALGGNssPsAKDIKKILDsVGIEADDDRLNKVIsELNGK
P05455	S94	Sugiyama	SSB	KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P05783	S177	Sugiyama	KRT18 CYK18 PIG46	ARLAADDFRVKyETELAMRQsVENDIHGLRKVIDDTNItRL
P05783	S93	Sugiyama	KRT18 CYK18 PIG46	GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P05787	S104	Sugiyama	KRT8 CYK8	IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787	S330	Sugiyama	KRT8 CYK8	MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P05787	S410	Sugiyama	KRT8 CYK8	TYRKLLEGEESRLEsGMQNMsIHtKTTSGYAGGLSSAYGGL
P06733	S291	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	IsPDQLADLyKsFIKDyPVVsIEDPFDQDDWGAWQKFtAsA
P06733	T26	Sugiyama	ENO1 ENO1L1 MBPB1 MPB1	IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P06899	S37	Sugiyama	H2BC11 H2BFR HIST1H2BJ	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P06899	S39	Sugiyama	H2BC11 H2BFR HIST1H2BJ	VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P07101	S40	SIGNOR\|iPTMNet\|EPSD	TH TYH	ELDAKQAEAIMVRGQGAPGPsLTGsPWPGTAAPAASYTPTP
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07205	S399	Sugiyama	PGK2 PGKB	CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205	T394	Sugiyama	PGK2 PGKB	GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07355	S184	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07602	S29	Sugiyama	PSAP GLBA SAP1	SLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVKHCL
P07602	T26	Sugiyama	PSAP GLBA SAP1	LLASLLGAALAGPVLGLKECtRGsAVWCQNVKTASDCGAVK
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07737	T65	Sugiyama	PFN1	PAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQDGEFs
P07737	Y60	Sugiyama	PFN1	FVNITPAEVGVLVGKDRssFyVNGLtLGGQKCsVIRDsLLQ
P07814	S739	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07900	S399	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900	S53	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900	S63	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900	S641	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD
P08238	S391	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238	S452	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P08238	S460	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S58	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08670	S325	Sugiyama	VIM	NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P08729	S104	Sugiyama	KRT7 SCL	LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P08758	T8	Sugiyama	ANXA5 ANX5 ENX2 PP4	_____________MAQVLRGtVtDFPGFDERADAEtLRKAM
P0C0S8	S2	GPS6\|SIGNOR\|ELM\|EPSD	H2AC11 H2AFP HIST1H2AG; H2AC13 H2AFC HIST1H2AI; H2AC15 H2AFD HIST1H2AK; H2AC16 H2AFI HIST1H2AL; H2AC17 H2AFN HIST1H2AM	___________________MsGRGKQGGKARAKAKTRssRA
P0CAP2	T184	Sugiyama	POLR2M GRINL1A	PSSEASEHHPRHRVssQAEDtSssFDNLFIDRLQRITIADQ
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG41	S140	Sugiyama	CTAGE8	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
P0DPH7	S48	Sugiyama	TUBA3C TUBA2	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P10276	S369	EPSD\|PSP	RARA NR1B1	DMLQEPLLEALKVYVRKRRPsRPHMFPKMLMKITDLRSISA
P10412	S36	Sugiyama	H1-4 H1F4 HIST1H1E	EKtPVKKKARKsAGAAKRKAsGPPVsELItKAVAASKERsG
P10809	S488	Sugiyama	HSPD1 HSP60	IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P11216	S430	Sugiyama	PYGB	RHLDHVAALFPGDVDRLRRMsVIEEGDCKRINMAHLCVIGS
P11274	S371	Sugiyama	BCR BCR1 D22S11	SRVsPsPTTyRMFRDKsRsPsQNsQQsFDSssPPtPQCHKR
P11532	S3623	Sugiyama	DMD	EAKVNGttVssPstsLQRsDssQPMLLRVVGSQTSDSMGEE
P11831	S103	EPSD\|PSP	SRF	sEsGEEEELGAERRGLKRsLsEMEIGMVVGGPEASAAATGG
P12035	S211	Sugiyama	KRT3	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P12268	S416	Sugiyama	IMPDH2 IMPD2	APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P12270	S135	Sugiyama	TPR	RTKEELEAEKRDLIRTNERLsQELEyLTEDVKRLNEKLKES
P12270	S2155	Sugiyama	TPR	PstPtLVVPHRtDGFAEAIHsPQVAGVPRFRFGPPEDMPQT
P12956	S477	Sugiyama	XRCC6 G22P1	EQVGKMKAIVEKLRFtYRsDsFENPVLQQHFRNLEALALDL
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639	S593	Sugiyama	EEF2 EF2	SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639	S732	Sugiyama	EEF2 EF2	DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13639	T5	Sugiyama	EEF2 EF2	________________MVNFtVDQIRAIMDKKANIRNMsVI
P13639	Y730	Sugiyama	EEF2 EF2	HADAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQ
P13647	S181	Sugiyama	KRT5	IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13667	S126	Sugiyama	PDIA4 ERP70 ERP72	NILKDKDPPIPVAKIDAtsAsVLAsRFDVsGyPtIKILKKG
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14314	S478	Sugiyama	PRKCSH G19P1	DKFSAMKyEQGtGCWQGPNRstTVRLLCGKEtMVtStTEPS
P14618	S202	Sugiyama	PKM OIP3 PK2 PK3 PKM2	SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618	S97	Sugiyama	PKM OIP3 PK2 PK3 PKM2	sHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGP
P14618	T95	Sugiyama	PKM OIP3 PK2 PK3 PKM2	NFsHGtHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTK
P14625	S514	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	LGVIEDHsNRtRLAKLLRFQssHHPtDItsLDQyVERMKEK
P14625	S746	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GyLLPDTKAYGDRIERMLRLsLNIDPDAKVEEEPEEEPEET
P14625	T171	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P14649	S87	Sugiyama	MYL6B MLC1SA	EEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVLK
P14866	S544	Sugiyama	HNRNPL HNRPL P/OKcl.14	LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P15311	S535	Sugiyama	EZR VIL2	EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311	T533	Sugiyama	EZR VIL2	NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15336	S62	Sugiyama	ATF2 CREB2 CREBP1	LAVHKHKHEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEV
P15374	S126	Sugiyama	UCHL3	NNKDKMHFESGSTLKKFLEEsVsMsPEERARyLENyDAIRV
P15531	S122	Sugiyama	NME1 NDPKA NM23	GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P16220	S119	SIGNOR\|PSP	CREB1	EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16333	S85	Sugiyama	NCK1 NCK	ASIVKNLKDTLGIGKVKRKPsVPDsAsPADDsFVDPGERLy
P16402	S37	Sugiyama	H1-3 H1F3 HIST1H1D	KtPVKKKAKKAGATAGKRKAsGPPVsELItKAVAASKERsG
P16949	S63	Sugiyama	STMN1 C1orf215 LAP18 OP18	KDLsLEEIQKKLEAAEERRKsHEAEVLKQLAEKREHEKEVL
P17544	S44	Sugiyama	ATF7 ATFA	LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P18583	S2009	Sugiyama	SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312	SRRSRTPSRRRRSRSVVRRRsFsIsPVRLRRSRTPLRRRFs
P18583	S2013	Sugiyama	SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312	RTPSRRRRSRSVVRRRsFsIsPVRLRRSRTPLRRRFsRsPI
P18615	S115	Sugiyama	NELFE RD RDBP	KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18615	S131	Sugiyama	NELFE RD RDBP	QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P18846	S63	SIGNOR\|iPTMNet\|EPSD\|PSP	ATF1	DsSDsIGssQKAHGILARRPsYRKILKDLsSEDTRGRKGDG
P18858	S901	Sugiyama	LIG1	DKQPEQATTSAQVACLYRKQsQIQNQQGEDsGsDPEDTY__
P19338	S458	Sugiyama	NCL	TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19419	S383	SIGNOR\|EPSD\|PSP	ELK1	tPVLLtPSSLPPSIHFWSTLsPIAPRsPAKLSFQFPSSGSA
P20290	S173	Sugiyama	BTF3 NACB OK/SW-cl.8	QLGADsLtsLRRLAEALPKQsVDGKAPLAtGEDDDDEVPDL
P20810	S366	Sugiyama	CAST	DKDGKPLLPEPEEKPKPRsEsELIDELsEDFDRsECKEKPS
P20810	S411	Sugiyama	CAST	KTEESKAAAPAPVSEAVCRtsMCsIQSAPPEPATLKGTVPD
P22033	S481	Sugiyama	MMUT MUT	EGIPKLRIEECAARRQARIDsGSEVIVGVNKYQLEKEDAVE
P22087	S124	Sugiyama	FBL FIB1 FLRN	DALVTKNLVPGEsVyGEKRVsIsEGDDKIEyRAWNPFRSKL
P22090	S204	Sugiyama	RPS4Y1 RPS4Y PRO2646	IGGANLGRVGVITNRERHPGsFDVVHVKDANGNSFATRLSN
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22736	S351	SIGNOR\|iPTMNet\|EPSD	NR4A1 GFRP1 HMR NAK1	GMVKEVVRTDsLKGRRGRLPsKPKQPPDAsPANLLtSLVRA
P23527	S37	Sugiyama	H2BC17 H2BFH H2BFN HIST1H2BO	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P23527	S39	Sugiyama	H2BC17 H2BFH H2BFN HIST1H2BO	VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISSKA
P23528	T63	Sugiyama	CFL1 CFL	DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528	T70	Sugiyama	CFL1 CFL	EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23588	S207	Sugiyama	EIF4B	DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588	S597	Sugiyama	EIF4B	KKPEENPASKFssASKyAALsVDGEDENEGEDyAE______
P24534	S141	Sugiyama	EEF1B2 EEF1B EF1B	ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P25054	S1389	Sugiyama	APC DP2.5	PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25054	S2129	Sugiyama	APC DP2.5	NSIVSSLHQAAAAACLsRQAssDSDSILSLKsGIsLGsPFH
P25205	S447	Sugiyama	MCM3	EQGRVTIAKAGIHARLNARCsVLAAANPVyGRyDQyKTPME
P25705	S65	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	KtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARVH
P25789	S7	Sugiyama	PSMA4 HC9 PSC9	______________MSRRyDsRttIFsPEGRLYQVEYAMEA
P25789	T10	Sugiyama	PSMA4 HC9 PSC9	___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P25789	Y5	Sugiyama	PSMA4 HC9 PSC9	________________MSRRyDsRttIFsPEGRLYQVEYAM
P26038	S576	Sugiyama	MSN	YKtLRQIRQGNTKQRIDEFEsM___________________
P26373	S181	Sugiyama	RPL13 BBC1 OK/SW-cl.46	YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373	T107	Sugiyama	RPL13 BBC1 OK/SW-cl.46	HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P26641	T287	Sugiyama	EEF1G EF1G PRO1608	EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27348	S63	Sugiyama	YWHAQ	LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR
P27448	S42	Sugiyama	MARK3 CTAK1 EMK2	GDGRQEVTSRTSRSGARCRNsIAsCADEQPHIGNyRLLKTI
P27708	S1859	Sugiyama	CAD	RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27797	T34	Sugiyama	CALR CRTC	LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29692	S162	Sugiyama	EEF1D EF1D	AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692	S44	Sugiyama	EEF1D EF1D	RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692	S64	Sugiyama	EEF1D EF1D	sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P29692	S86	Sugiyama	EEF1D EF1D	GPGAssGtsGDHGELVVRIAsLEVENQsLRGVVQELQQAIs
P30043	T190	Sugiyama	BLVRB FLR SCAN	RGPSRVISKHDLGHFMLRCLttDEyDGHstyPsHQyQ____
P30048	S86	Sugiyama	PRDX3 AOP1	TQHAPYFKGTAVVNGEFKDLsLDDFKGKYLVLFFYPLDFTF
P30086	S52	Sugiyama	PEBP1 PBP PEBP	AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30086	S54	Sugiyama	PEBP1 PBP PEBP	VDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAP
P30086	T51	Sugiyama	PEBP1 PBP PEBP	GAAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDP
P30533	S242	Sugiyama	LRPAP1 A2MRAP	TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P30533	S247	Sugiyama	LRPAP1 A2MRAP	KLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQSA
P30533	Y246	Sugiyama	LRPAP1 A2MRAP	EKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWDLAQS
P31946	S65	Sugiyama	YWHAB	LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR
P32119	S112	Sugiyama	PRDX2 NKEFB TDPX1	KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P33176	S663	Sugiyama	KIF5B KNS KNS1	IKSLtEyLQNVEQKKRQLEEsVDALSEELVQLRAQEKVHEM
P33316	S120	Sugiyama	DUT	PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33316	S130	Sugiyama	DUT	GGMQLRFARLsEHAtAPTRGsARAAGYDLYSAYDYTIPPME
P33778	S37	Sugiyama	H2BC3 H2BFF HIST1H2BB	KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P33778	S39	Sugiyama	H2BC3 H2BFF HIST1H2BB	ITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISSKA
P34932	S76	Sugiyama	HSPA4 APG2 HSPH2	VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35269	T154	Sugiyama	GTF2F1 RAP74	AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269	T156	Sugiyama	GTF2F1 RAP74	EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35908	S191	Sugiyama	KRT2 KRT2A KRT2E	IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P37108	S25	Sugiyama	SRP14	EsEQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGt
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837	S13	Sugiyama	TALDO1 TAL TALDO TALDOR	________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P40763	S727	GPS6\|SIGNOR\|EPSD	STAT3 APRF	KTKFICVtPttCsNtIDLPMsPRTLDSLMQFGNNGEGAEPS
P40818	S719	Sugiyama	USP8 KIAA0055 UBPY	KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41091	T109	Sugiyama	EIF2S3 EIF2G	YKLDDPSCPRPECyRSCGsstPDEFPtDIPGtKGNFKLVRH
P42224	S727	EPSD	STAT1	IsVsEVHPSRLQttDNLLPMsPEEFDEVSRIVGsVEFDSMM
P42677	T74	Sugiyama	RPS27 MPS1	VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P43121	S93	Sugiyama	MCAM MUC18	IFRVRQGQGQSEPGEYEQRLsLQDRGAtLALtQVtPQDERI
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243	S195	Sugiyama	MATR3 KIAA0723	RDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRsQEsGyyD
P43243	S234	Sugiyama	MATR3 KIAA0723	yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43243	T150	Sugiyama	MATR3 KIAA0723	EDKItPENLPQILLQLKRRRtEEGPtLsyGRDGRsAtREPP
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46060	S454	Sugiyama	RANGAP1 KIAA1835 SD	VstFLAFPsPEKLLRLGPKssVLIAQQTDTSDPEKVVSAFL
P46776	S68	Sugiyama	RPL27A	yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46779	S115	Sugiyama	RPL28	HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P46937	S109	Sugiyama	YAP1 YAP65	RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P47712	S727	SIGNOR\|iPTMNet\|EPSD\|Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48637	S276	Sugiyama	GSS	VDGQEIAVVYFRDGYMPRQYsLQNWEARLLLERSHAAKCPD
P48668	S176	Sugiyama	KRT6C KRT6E	IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P49419	S84	Sugiyama	ALDH7A1 ATQ1	EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49792	T3217	Sugiyama	RANBP2 NUP358	DTVKKIESFGsPKGSVCRRItITECGQI_____________
P49815	T1462	Sugiyama	TSC2 TSC4	EGPLPsssPRsPsGLRPRGYtIsDsAPsRRGKRVERDALKS
P49840	S21	Sugiyama	GSK3A	MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs
P49840	Y279	Sugiyama	GSK3A	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841	Y216	Sugiyama	GSK3B	LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P50454	S139	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P50454	S141	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	STARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHSKI
P50549	S191	GPS6\|iPTMNet\|EPSD	ETV1 ER81	PSQSIPDSSYPMDHRFRRQLsEPCNSFPPLPTMPREGRPMY
P50549	S216	GPS6\|SIGNOR\|iPTMNet\|EPSD	ETV1 ER81	SFPPLPTMPREGRPMYQRQMsEPNIPFPPQGFKQEYHDPVY
P50549	S334	iPTMNet\|EPSD	ETV1 ER81	GDIKQEPGMYREGPTYQRRGsLQLWQFLVALLDDPSNSHFI
P50991	S51	Sugiyama	CCT4 CCTD SRB	AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt
P51116	S504	Sugiyama	FXR2 FMR1L2	PTGGRGRGPPPAPRPTSRYNsSsISSVLKDPDsNPYSLLDt
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51116	T598	Sugiyama	FXR2 FMR1L2	DESRPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRA
P52298	S13	Sugiyama	NCBP2 CBP20 PIG55	________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52597	S265	Sugiyama	HNRNPF HNRPF	EySGLSDGYGFTTDLFGRDLsyCLsGMyDHRYGDsEFtVQs
P52907	S119	Sugiyama	CAPZA1	DHLRKEAsDPQPEEADGGLKsWREsCDsALRAYVKDHYSNG
P52907	S123	Sugiyama	CAPZA1	KEAsDPQPEEADGGLKsWREsCDsALRAYVKDHYSNGFCTV
P52943	S115	Sugiyama	CRIP2 CRP2	AARAEERKAsGPPKGPsRAssVttFtGEPNtCPRCSKKVYF
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P54253	S775	EPSD\|PSP	ATXN1 ATX1 SCA1	APFLTKIEPSKPAATRKRRWsAPESRKLEKSEDEPPLTLPK
P55196	S1774	Sugiyama	AFDN AF6 MLLT4	TGAAVGAHDACRDAKEKRsKsQDADsPGssGAPENLTFKER
P57053	S37	Sugiyama	H2BC12L H2BFS H2BS1	KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P57053	S39	Sugiyama	H2BC12L H2BFS H2BS1	VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P57721	T159	Sugiyama	PCBP3 PCBP3-OT1 PCBP3OT	sQCGsLIGKGGSKIKEIREstGAQVQVAGDMLPNstERAVT
P58876	S37	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876	S39	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60468	S49	Sugiyama	SEC61B	STVRQRKNASCGTRSAGRtTsAGTGGMWRFYTEDSPGLKVG
P60660	S30	Sugiyama	MYL6	AEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVLK
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S239	Sugiyama	ACTB	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60983	T27	Sugiyama	GMFB	VCDVAEDLVEKLRKFRFRKEtNNAAIIMKIDKDKRLVVLDE
P61081	S175	Sugiyama	UBE2M UBC12	NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61353	S86	Sugiyama	RPL27	SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61978	S417	Sugiyama	HNRNPK HNRPK	DLAGsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITI
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	S64	Sugiyama	YWHAG	LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA
P62195	S120	Sugiyama	PSMC5 SUG1	DKNIDINDVtPNCRVALRNDsytLHKILPNKVDPLVSLMMV
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258	S148	Sugiyama	YWHAE	YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62304	S89	Sugiyama	SNRPE	KSRKQLGRIMLKGDNITLLQsVsN_________________
P62701	S204	Sugiyama	RPS4X CCG2 RPS4 SCAR	tGGANLGRIGVITNRERHPGsFDVVHVKDANGNSFATRLsN
P62701	T247	Sugiyama	RPS4X CCG2 RPS4 SCAR	VIGKGNKPWIsLPRGKGIRLtIAEERDKRLAAKQSSG____
P62736	S241	Sugiyama	ACTA2 ACTSA ACTVS GIG46	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62807	S37	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62807	S39	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917	S130	Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917	S14	Sugiyama	RPL8	_______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62937	S51	Sugiyama	PPIA CYPA	KtAENFRALSTGEKGFGYKGsCFHRIIPGFMCQGGDFtRHN
P62942	T22	Sugiyama	FKBP1A FKBP1 FKBP12	GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62979	S123	Sugiyama	RPS27A UBA80 UBCEP1	LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63146	S142	Sugiyama	UBE2B RAD6B UBCH1	ANSQAAQLYQENKREYEKRVsAIVEQsWNDS__________
P63220	S31	Sugiyama	RPS21	LYVPRKCSASNRIIGAKDHAsIQMNVAEVDKVTGRFNGQFK
P63220	S65	Sugiyama	RPS21	RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S239	Sugiyama	ACTG1 ACTG	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267	S240	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809	S102	Sugiyama	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809	S136	Sugiyama	YBX1 NSEP1 YB1	GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809	Y99	Sugiyama	YBX1 NSEP1 YB1	DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032	S241	Sugiyama	ACTC1 ACTC	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68104	T432	Sugiyama	EEF1A1 EEF1A EF1A LENG7	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133	S241	Sugiyama	ACTA1 ACTA	VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68363	S48	Sugiyama	TUBA1B	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
P68431	S11	GPS6\|SIGNOR\|EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	__________MARtKQtARKstGGKAPRKQLATKAARKsAP
P68431	S29	GPS6\|SIGNOR\|EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	RKstGGKAPRKQLATKAARKsAPATGGVKKPHRyRPGtVAL
P78345	S253	Sugiyama	RPP38	DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P83731	S86	Sugiyama	RPL24	EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731	T83	Sugiyama	RPL24	QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84098	S13	Sugiyama	RPL19	________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEIA
P84243	S11	GPS6\|SIGNOR	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	__________MARtKQTARKstGGKAPRKQLATKAARKsAP
P84243	S29	GPS6\|SIGNOR	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	RKstGGKAPRKQLATKAARKsAPsTGGVKKPHRyRPGtVAL
Q00537	S137	Sugiyama	CDK17 PCTAIRE2 PCTK2	SDEVQsPtGVCLRNRIHRRIsMEDLNKRLsLPADIRIPDGY
Q00587	S192	Sugiyama	CDC42EP1 BORG5 CEP1 MSE55	PHDRDRDGsFPsEPGLRRsDsLLsFRLDLDLGPSLLSELLG
Q01082	S1388	Sugiyama	SPTBN1 SPTB2	TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01105	S168	Sugiyama	SET	ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01546	S196	Sugiyama	KRT76 KRT2B KRT2P	IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q01650	S31	Sugiyama	SLC7A5 CD98LC LAT1 MPE16	LAAPAAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNIT
Q01650	S35	Sugiyama	SLC7A5 CD98LC LAT1 MPE16	AAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNITLLNG
Q02543	S123	Sugiyama	RPL18A	AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q02818	S369	Sugiyama	NUCB1 NUC	RFEEELAAREAELNAKAQRLsQETEALGRsQGRLEAQKREL
Q04206	S276	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	RELA NFKB3	PYADPsLQAPVRVsMQLRRPsDRELsEPMEFQYLPDTDDRH
Q04917	S64	Sugiyama	YWHAH YWHA1	LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA
Q05639	T432	Sugiyama	EEF1A2 EEF1AL STN	VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06210	S261	Sugiyama	GFPT1 GFAT GFPT	GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q07020	T85	Sugiyama	RPL18	RMIRKMKLPGRENKtAVVVGtItDDVRVQEVPKLKVCALRV
Q07666	S20	Sugiyama	KHDRBS1 SAM68	_MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q07866	S524	Sugiyama	KLC1 KLC KNS2	QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q08211	S449	Sugiyama	DHX9 DDX9 LKP NDH2	FIQNDRAAECNIVVTQPRRIsAVsVAERVAFERGEEPGKSC
Q08211	S452	Sugiyama	DHX9 DDX9 LKP NDH2	NDRAAECNIVVTQPRRIsAVsVAERVAFERGEEPGKSCGYS
Q08AD1	S1313	Sugiyama	CAMSAP2 CAMSAP1L1 KIAA1078	sLNtGDNEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWE
Q09028	S147	Sugiyama	RBBP4 RBAP48	VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q09161	S22	Sugiyama	NCBP1 CBP80 NCBP	SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q12770	S822	Sugiyama	SCAP KIAA0199 PSEC0227	DAQTGDCLTRIPRPGRQRRDsGVGsGLEAQEsWERLsDGGK
Q12802	S1507	Sugiyama	AKAP13 BRX HT31 LBC	HGsDVSLSQILKPNRSRDRQsLDGFysHGMGAEGRESESEP
Q12965	S1002	Sugiyama	MYO1E MYO1C	RSNQKSLyTsMARPPLPRQQstssDRVsQtPEsLDFLKVPD
Q12965	T936	Sugiyama	MYO1E MYO1C	LQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAP
Q13017	S1195	Sugiyama	ARHGAP5 RHOGAP5	AsDDEAFttSKTKRKGRHRGsEEDPLLsPVETWKGGIDNPA
Q13185	S93	PSP	CBX3	IEAFLNSQKAGKEKDGtKRKsLsDsEsDDsKSKKKRDAADK
Q13247	S299	Sugiyama	SRSF6 SFRS6 SRP55	RSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPP
Q13247	S301	Sugiyama	SRSF6 SFRS6 SRP55	PKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKR
Q13263	S473	Sugiyama	TRIM28 KAP1 RNF96 TIF1B	sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q13283	S250	Sugiyama	G3BP1 G3BP	sssPAPADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGI
Q13283	S253	Sugiyama	G3BP1 G3BP	PAPADIAQtVQEDLRtFsWAsVtsKNLPPSGAVPVTGIPPH
Q13428	S996	Sugiyama	TCOF1	AQAQAAstPRKARASESTARssssEsEDEDVIPAtQCLtPG
Q13428	S999	Sugiyama	TCOF1	QAAstPRKARASESTARssssEsEDEDVIPAtQCLtPGIRT
Q13442	S19	Sugiyama	PDAP1 HASPP28	__MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEEE
Q13442	S57	Sugiyama	PDAP1 HASPP28	EEEQKEGGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGV
Q13442	T18	Sugiyama	PDAP1 HASPP28	___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13501	S24	Sugiyama	SQSTM1 ORCA OSIL	LTVKAYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPC
Q13541	S65	SIGNOR\|iPTMNet\|EPSD	EIF4EBP1	ttPGGtRIIyDRKFLMECRNsPVtKtPPRDLPtIPGVtsPs
Q13541	T36	iPTMNet\|EPSD	EIF4EBP1	PATRRVVLGDGVQLPPGDysttPGGtLFsttPGGtRIIyDR
Q13541	T37	SIGNOR	EIF4EBP1	ATRRVVLGDGVQLPPGDysttPGGtLFsttPGGtRIIyDRK
Q13541	T45	SIGNOR\|iPTMNet\|EPSD	EIF4EBP1	DGVQLPPGDysttPGGtLFsttPGGtRIIyDRKFLMECRNs
Q13541	T46	SIGNOR	EIF4EBP1	GVQLPPGDysttPGGtLFsttPGGtRIIyDRKFLMECRNsP
Q13541	T70	SIGNOR	EIF4EBP1	tRIIyDRKFLMECRNsPVtKtPPRDLPtIPGVtsPssDEPP
Q13561	Y86	Sugiyama	DCTN2 DCTN50	GLDFsDRIGKTKRtGyEsGEyEMLGEGLGVKETPQQKYQRL
Q13769	S314	Sugiyama	THOC5 C22orf19 KIAA0983	VDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQLD
Q14011	S163	Sugiyama	CIRBP A18HNRNP CIRP	SSRsQsGGYSDRssGGsyRDsyDsyATHNE___________
Q14151	S818	Sugiyama	SAFB2 KIAA0138	QHYGDDRHGHGGPPERHGRDsRDGWGGyGsDKRLsEGRGLP
Q14152	S492	Sugiyama	EIF3A EIF3S10 KIAA0139	VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14152	S988	Sugiyama	EIF3A EIF3S10 KIAA0139	PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14155	S518	Sugiyama	ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314	ERYLLLFPNVLLMLSASPRMsGFIyQGKLPtTGMTITKLED
Q14157	S852	Sugiyama	UBAP2L KIAA0144 NICE4	LDyysIPFPtPttPLtGRDGsLAsNPysGDLtKFGRGDASS
Q14204	S4368	Sugiyama	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	MLEDEDDLAyAETEKKTRtDstsDGRPAWMRTLHTTASNWL
Q14432	S312	Sugiyama	PDE3A	sssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKRG
Q14432	T311	Sugiyama	PDE3A	RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14498	S336	Sugiyama	RBM39 HCC1 RNPC2	LAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGR
Q14566	S498	Sugiyama	MCM6	EQQTISITKAGVKATLNARTsILAAANPIsGHyDRSKSLKQ
Q14568	S53	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14671	S709	Sugiyama	PUM1 KIAA0099 PUMH1	LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14676	T447	Sugiyama	MDC1 KIAA0170 NFBD1	WNRDAEEDMPQRVVLLQRsQtttERDsDtDVEEEELPVENR
Q14697	S187	Sugiyama	GANAB G2AN KIAA0088	LLsVNARGLLEFEHQRAPRVsQGsKDPAEGDGAQPEEtPRD
Q14847	S146	Sugiyama	LASP1 MLN50	FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q14978	S87	Sugiyama	NOLC1 KIAA0035 NS5ATP13	KLQANGPVAKKAKKKAsssDsEDssEEEEEVQGPPAKKAAV
Q14CN4	S138	Sugiyama	KRT72 K6IRS2 KB35 KRT6 KRT6IRS2	IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q15052	S488	Sugiyama	ARHGEF6 COOL2 KIAA0006 PIXA	ERYLMLFSNVLIMLSASPRMsGFIYQGKIPIAGTVVTRLDE
Q15185	S113	Sugiyama	PTGES3 P23 TEBP	RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185	S72	Sugiyama	PTGES3 P23 TEBP	EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE
Q15365	T127	Sugiyama	PCBP1	TQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15366	T127	Sugiyama	PCBP2	sQCGsLIGKGGCKIKEIREstGAQVQVAGDMLPNstERAIT
Q15424	S794	Sugiyama	SAFB HAP HET SAFB1	EREGQHYPERHGGPERHGRDsRDGWGGyGsDKRMsEGRGLP
Q15527	S183	Sugiyama	SURF2	sDDsMtDLYPPELFTRKDLGstEDGDGtDDFLtDKEDEKAK
Q15545	S171	Sugiyama	TAF7 TAF2F TAFII55	TAKKKYIEsPDVEKEVKRLLstDAEAVSTRWEIIAEDETKE
Q15643	S464	Sugiyama	TRIP11 CEV14	SLLKLNNEyEVIKSTATRDIsLDsELHDLRLNLEAKEQELN
Q15785	S93	Sugiyama	TOMM34 URCC3	DCTSALALVPFSIKPLLRRAsAyEALEKYPMAYVDYKTVLQ
Q15831	S428	iPTMNet\|EPSD	STK11 LKB1 PJS	GRAPNPARKACSASSKIRRLsACKQQ_______________
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16513	T958	Sugiyama	PKN2 PRK2 PRKCL2	RGREDVSNFDDEFtsEAPILtPPREPRILsEEEQEMFRDFD
Q16576	S146	Sugiyama	RBBP7 RBAP46	VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16695	S11	SIGNOR\|iPTMNet\|EPSD	H3-4 H3FT HIST3H3	__________MARtKQTARKsTGGKAPRKQLATKVARKsAP
Q16695	S29	GPS6\|SIGNOR\|iPTMNet\|EPSD	H3-4 H3FT HIST3H3	RKsTGGKAPRKQLATKVARKsAPATGGVKKPHRyRPGtVAL
Q16778	S37	Sugiyama	H2BC21 H2BFQ HIST2H2BE	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q16778	S39	Sugiyama	H2BC21 H2BFQ HIST2H2BE	VTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIssKA
Q2NKX8	S1028	Sugiyama	ERCC6L PICH	DEPEEVVVKAKIRSKARRIVsDGEDEDDsFKDtssINPFNT
Q32MZ4	S120	Sugiyama	LRRFIP1 GCF2 TRIP	MPGLSAAtLAsLGGtssRRGsGDtsISIDTEASIREIKELN
Q32MZ4	S124	Sugiyama	LRRFIP1 GCF2 TRIP	SAAtLAsLGGtssRRGsGDtsISIDTEASIREIKELNELKD
Q32MZ4	T123	Sugiyama	LRRFIP1 GCF2 TRIP	LSAAtLAsLGGtssRRGsGDtsISIDTEASIREIKELNELK
Q3MII6	S506	Sugiyama	TBC1D25 OATL1	DHLATASQGPGGGGRLLRQAsLDGLQQLRDNMGSRRDPLVQ
Q3SY84	S143	Sugiyama	KRT71 K6IRS1 KB34 KRT6IRS1	IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q4G0J3	T257	Sugiyama	LARP7 HDCMA18P	KEENMDtsNtsIsKMKRsRPtsEGsDIEstEPQKQCSKKKK
Q562R1	S240	Sugiyama	ACTBL2	VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q58FF6	S34	Sugiyama	HSP90AB4P	IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7	S58	Sugiyama	HSP90AB3P HSP90BC	IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8	S58	Sugiyama	HSP90AB2P HSP90BB	IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5JTW2	S644	Sugiyama	CEP78 C9orf81	EGLGTSSNNLGVPATEQRQEsFEGFIARMCsPSPDATSGTG
Q5QNW6	S37	Sugiyama	H2BC18 HIST2H2BF	KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5QNW6	S39	Sugiyama	H2BC18 HIST2H2BF	VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5SW79	S881	Sugiyama	CEP170 FAM68A KAB KIAA0470	sstPssLALtsAsRIRERsEsLDPDssMDTtLILKDTEAVM
Q5T0N5	S488	Sugiyama	FNBP1L C1orf39 TOCA1	NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD
Q5T1M5	S1162	Sugiyama	FKBP15 KIAA0674	EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5TCZ1	S1038	Sugiyama	SH3PXD2A FISH KIAA0418 SH3MD1 TKS5	FSTARSAAAEAKGRLAERAAsQGsDsPLLPAQRNsIPVsPV
Q5TCZ1	S1041	Sugiyama	SH3PXD2A FISH KIAA0418 SH3MD1 TKS5	ARSAAAEAKGRLAERAAsQGsDsPLLPAQRNsIPVsPVRPK
Q5VT52	S1068	Sugiyama	RPRD2 KIAA0460 HSPC099	SLTATDQQQQEEHYRIETRVsssCLDLPDSTEEKGAPIETL
Q5VTE0	T432	Sugiyama	EEF1A1P5 EEF1AL3	VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q5VYS8	S132	Sugiyama	TUT7 HS2 KIAA1711 ZCCHC6	NWREFKPGPRIPVINRQRKDsFQENEDGYRWQDTRGCRTVR
Q5XKE5	S155	Sugiyama	KRT79 K6L KB38 KRT6L	IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6DN03	S37	Sugiyama	H2BC20P HIST2H2BC	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DN03	S39	Sugiyama	H2BC20P HIST2H2BC	VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6DRA6	S37	Sugiyama	H2BC19P HIST2H2BD	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DRA6	S39	Sugiyama	H2BC19P HIST2H2BD	VTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWCKA
Q6FI13	S2	GPS6\|EPSD	H2AC18 H2AFO HIST2H2AA HIST2H2AA3; H2AC19 HIST2H2AA4	___________________MsGRGKQGGKARAKAKSRssRA
Q6GYQ0	T798	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	tGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDMS
Q6P158	S605	Sugiyama	DHX57	SLNGPPEKVANIICTQPRRIsAISVAERVAKERAERVGLTV
Q6P1L5	S208	Sugiyama	FAM117B ALS2CR13	PEKRSPsAPVCKAGDKTRQPsssPsSIIRRtssLDtLAAPY
Q6PCE3	S175	Sugiyama	PGM2L1 BM32A	PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6PEY2	S48	Sugiyama	TUBA3E	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q6PKG0	S627	Sugiyama	LARP1 KIAA0731 LARP	FLFDEEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVt
Q6PKG0	S824	Sugiyama	LARP1 KIAA0731 LARP	VKEGRTLDAKMPRKRKtRHssNPPLEsHVGWVMDSREHRPR
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3	S939	Sugiyama	POTEE A26C1A POTE2	VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6ZN18	S206	Sugiyama	AEBP2	DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q6ZUT9	S691	Sugiyama	DENND5B	NRWVSRSATAQRRKERLRQHsEHVGLDNDLREKYMQEARSL
Q70E73	S996	Sugiyama	RAPH1 ALS2CR18 ALS2CR9 KIAA1681 LPD PREL2 RMO1	QRNssIKsSSGAEHPEPKRPsVDSLVSKFtPPAEsGsPsKE
Q71DI3	S11	GPS6	H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D	__________MARtKQTARKsTGGKAPRKQLATKAARKsAP
Q71DI3	S29	GPS6	H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D	RKsTGGKAPRKQLATKAARKsAPATGGVKKPHRyRPGtVAL
Q71U36	S48	Sugiyama	TUBA1A TUBA3	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q71UM5	T74	Sugiyama	RPS27L	VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q76FK4	S296	Sugiyama	NOL8 C9orf34 NOP132	QKLKNLPFKTSGLETAKKRNsIsDDDtDsEDELRMMIAKEE
Q7L7L0	S2	GPS6\|SIGNOR\|iPTMNet\|EPSD	H2AC25 H2AW HIST3H2A	___________________MsGRGKQGGKARAKAKSRSsRA
Q7RTS7	S153	Sugiyama	KRT74 K6IRS4 KB37 KRT5C KRT6IRS4	IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z401	S1225	Sugiyama	DENND4A IRLB MYCPBP	AEEIVMYMNNMssPLTSRtPsIDLQRACDDKLNKKsPPLVK
Q7Z417	S655	Sugiyama	NUFIP2 KIAA1321 PIG1	LGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsIWNL
Q7Z4V5	S395	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	REDDEPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKK
Q7Z4V5	S396	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	EDDEPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKKP
Q7Z5L9	S15	Sugiyama	IRF2BP2	______MAAAVAVAAASRRQsCyLCDLPRMPWAMIWDFTEP
Q7Z5L9	S455	Sugiyama	IRF2BP2	AGGSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVG
Q7Z5L9	Y17	Sugiyama	IRF2BP2	____MAAAVAVAAASRRQsCyLCDLPRMPWAMIWDFTEPVC
Q7Z794	S177	Sugiyama	KRT77 KRT1B	IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86UF2	S140	Sugiyama	CTAGE6 CTAGE6P	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q86V48	S957	Sugiyama	LUZP1	PTRIGKNVESTNSNAytQRsstDFsELEQPRSCLFEQGTRR
Q86V81	S142	Sugiyama	ALYREF ALY BEF THOC4	IQELFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKA
Q86V81	S145	Sugiyama	ALYREF ALY BEF THOC4	LFAEFGtLKKAAVHYDRsGRsLGtADVHFERKADALKAMKQ
Q86V81	S239	Sugiyama	ALYREF ALY BEF THOC4	tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86Y46	S145	Sugiyama	KRT73 K6IRS3 KB36 KRT6IRS3	IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8IUE6	S2	GPS6\|EPSD	H2AC21 HIST2H2AB	___________________MsGRGKQGGKARAKAKSRssRA
Q8IWT6	S217	PSP	LRRC8A KIAA1437 LRRC8 SWELL1 UNQ221/PRO247	KsstVsEDVEATVPMLQRtKsRIEQGIVDRSETGVLDKKEG
Q8IX12	S1091	Sugiyama	CCAR1 CARP1 DIS	NLENsNKsLsGELREVKKDLsQLQENLKISENMNLQFENQM
Q8IX94	S140	Sugiyama	CTAGE4	AAAEEARSLEATCEKLNRsNsELEDEILCLEKDLKEEKSKH
Q8N0Z3	S810	Sugiyama	SPICE1 CCDC52 SPICE	APESSKCSTVsPVSGINTRRssGATGNSCsPLNATSGSGRF
Q8N257	S37	Sugiyama	H2BC26 H2BU1 HIST3H2BB	KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss
Q8N257	S39	Sugiyama	H2BC26 H2BU1 HIST3H2BB	VTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIssKA
Q8N6T3	S345	Sugiyama	ARFGAP1 ARF1GAP	DQSFWETFGSAEPTKtRKsPssDsWtCADtstERRssDsWE
Q8N6T3	S361	Sugiyama	ARFGAP1 ARF1GAP	RKsPssDsWtCADtstERRssDsWEVWGSASTNRNSNsDGG
Q8N8S7	S125	Sugiyama	ENAH MENA	MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBJ7	T165	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	LHVSWNDARAYCAWRGKRLPtEEEWEFAARGGLKGQVYPWG
Q8NBK3	T372	Sugiyama	SUMF1 PSEC0152 UNQ3037/PRO9852	NTPDSsAsNLGFRCAADRLPtMD__________________
Q8ND56	T384	Sugiyama	LSM14A C19orf13 FAM61A RAP55 RAP55A	DKTKsFFDNIsCDDNRERRPtWAEERRLNAETFGIPLRPNR
Q8TAM6	S280	Sugiyama	ERMN KIAA1189	TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TD47	T247	Sugiyama	RPS4Y2 RPS4Y2P	VIGNGNKPWISLPRGKGIRLtIAEERDKRLAAKQSSG____
Q8WWI1	S805	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	LQDRESQNQKSTVPSRRRMysFDDVLEEGKRPPtMtVSEAS
Q8WWI1	Y804	Sugiyama	LMO7 FBX20 FBXO20 KIAA0858	MLQDRESQNQKSTVPSRRRMysFDDVLEEGKRPPtMtVSEA
Q92597	S330	Sugiyama	NDRG1 CAP43 DRG1 RTP	QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92766	S1167	Sugiyama	RREB1 FINB	AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q92934	S118	SIGNOR	BAD BBC6 BCL2L8	RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934	S153	iPTMNet\|EPSD	BAD BBC6 BCL2L8	KsAGtATQMRQSSSWTRVFQsWWDRNLGRGSSAPSQ_____
Q93077	S2	GPS6\|EPSD	H2AC6 H2AFL HIST1H2AC	___________________MsGRGKQGGKARAKAKSRssRA
Q93079	S37	Sugiyama	H2BC9 H2BFJ HIST1H2BH	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q93079	S39	Sugiyama	H2BC9 H2BFJ HIST1H2BH	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96AQ6	S147	Sugiyama	PBXIP1 HPIP	PQSLPSTPKAAWIREEGRCsssDDDTDVDMEGLRRRRGREA
Q96BY7	S497	Sugiyama	ATG2B C14orf103	PSNLVHPTPLQKtsLPsRsVsVDESRPELIFRLAVGTFSIS
Q96C19	S74	Sugiyama	EFHD2 SWS1	ELSAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQI
Q96C19	S76	Sugiyama	EFHD2 SWS1	SAKLLRRADLNQGIGEPQsPsRRVFNPytEFKEFSRKQIKD
Q96C86	S24	Sugiyama	DCPS DCS1 HINT5 HSPC015	AAPQLGKRKRELDVEEAHAAstEEKEAGVGNGTCAPVRLPF
Q96C86	T25	Sugiyama	DCPS DCS1 HINT5 HSPC015	APQLGKRKRELDVEEAHAAstEEKEAGVGNGTCAPVRLPFS
Q96CW6	S32	Sugiyama	SLC7A6OS	KRKRsAEPAEALVLACKRLRsDAVESAAQKTSEGLERAAEN
Q96CW6	T177	Sugiyama	SLC7A6OS	KTSDPDVILCNsVELIRERLtVSEDGPGVRRQEEQKHDDYV
Q96D71	S273	Sugiyama	REPS1	QTTVRTVASATTAIEIRRQsssyDDPWKItDEQRQYYVNQF
Q96G46	S276	Sugiyama	DUS3L	RQENCGAQQVPAGPGtstPPssPVRtCGPLtDEDVVRLRPC
Q96G46	T273	Sugiyama	DUS3L	GAPRQENCGAQQVPAGPGtstPPssPVRtCGPLtDEDVVRL
Q96IZ0	T230	Sugiyama	PAWR PAR4	GSsyLLQEPPRTVSGRyKsttsVsEEDVsSRYsRTDRSGFP
Q96JP5	S85	Sugiyama	ZFP91 ZNF757 FKSG11	AAAVSRRRKAEYPRRRRssPsARPPDVPGQQPQAAKsPsPV
Q96KK5	S2	GPS6\|EPSD	H2AC12 HIST1H2AH HIST1H2AI	___________________MsGRGKQGGKARAKAKTRssRA
Q96MH2	S194	Sugiyama	HEXIM2 L3	EAGDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELV
Q96MH2	T196	Sugiyama	HEXIM2 L3	GDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELVRD
Q96PK6	S520	Sugiyama	RBM14 SIP	AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q96QV6	S2	GPS6\|EPSD	H2AC1 H2AFR HIST1H2AA	___________________MsGRGKQGGKARAKSKSRSsRA
Q96RU3	S497	Sugiyama	FNBP1 FBP17 KIAA0554	AWLAEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREs
Q99877	S37	Sugiyama	H2BC15 H2BFD HIST1H2BN	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99877	S39	Sugiyama	H2BC15 H2BFD HIST1H2BN	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99878	S2	GPS6\|EPSD	H2AC14 H2AFE HIST1H2AJ	___________________MsGRGKQGGKARAKAKTRssRA
Q99879	S37	Sugiyama	H2BC14 H2BFE HIST1H2BM	KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879	S39	Sugiyama	H2BC14 H2BFE HIST1H2BM	INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880	S37	Sugiyama	H2BC13 H2BFC HIST1H2BL	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880	S39	Sugiyama	H2BC13 H2BFC HIST1H2BL	VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BQE3	S439	Sugiyama	TUBA1C TUBA6	SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3	S48	Sugiyama	TUBA1C TUBA6	HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV
Q9BRA2	S41	Sugiyama	TXNDC17 TXNL5	QHNGKTIFAyFTGSKDAGGKsWCPDCVQAEPVVREGLKHIS
Q9BTC0	S1456	Sugiyama	DIDO1 C20orf158 DATF1 KIAA0333	EAKVTVDDLPNRMCADVRRNsVERPAEPVAGAAtPsLVEQQ
Q9BTE6	S174	Sugiyama	AARSD1	IEQSVNEKIRDRLPVNVRELsLDDPEVEQVsGRGLPDDHAG
Q9BW19	T159	Sugiyama	KIFC1 HSET KNSL2	LKGQLCDLNAELKRCRERtQtLDQENQQLQDQLRDAQQQVK
Q9BW27	S652	Sugiyama	NUP85 NUP75 PCNT1	VEMLRLSLARNLARAIIREGsLEGS________________
Q9BY44	S526	Sugiyama	EIF2A CDA02 MSTP004 MSTP089	sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BYX7	S239	Sugiyama	POTEKP ACTBL3 FKSG30	VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BZL6	S197	Sugiyama	PRKD2 PKD2 HSPC187	HKRCAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPC
Q9BZL6	S198	Sugiyama	PRKD2 PKD2 HSPC187	KRCAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPCT
Q9C0C2	S1620	Sugiyama	TNKS1BP1 KIAA1741 TAB182	ADsDAHLFQDSTEPRAsRVPssDEEVVEEPQsRRTRMsLGT
Q9C0C2	S221	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TyGtTTAPRDEDGstLFRGWsQEGPVKsPAECREEHsKtPE
Q9C0C2	S429	Sugiyama	TNKS1BP1 KIAA1741 TAB182	EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9C0C2	S920	Sugiyama	TNKS1BP1 KIAA1741 TAB182	QDANEQGQDLGKRDHHGRyssQDADEQDWEFQKRDVsLGTy
Q9C0C2	Y918	Sugiyama	TNKS1BP1 KIAA1741 TAB182	AsQDANEQGQDLGKRDHHGRyssQDADEQDWEFQKRDVsLG
Q9C0H5	S604	Sugiyama	ARHGAP39 KIAA1688	GYESDGALPLPMPGPVVRAFsEDEALAQQENRHWRRGtFEK
Q9H2U1	S268	Sugiyama	DHX36 DDX36 KIAA1488 MLEL1 RHAU	YIERGKGSACRIVCTQPRRIsAISVAERVAAERAEsCGSGN
Q9H3H1	S431	Sugiyama	TRIT1 IPT MOD5	AAHIKSKSHLNQLKKRRRLDsDAVNTIEsQsVsPDHNKEPK
Q9H4A3	T60	EPSD\|PSP	WNK1 HSN2 KDP KIAA0344 PRKWNK1	GAAAADAVtGRtEEyRRRRHtMDKDSRGAAAtTtTTEHRFF
Q9H6H4	S152	Sugiyama	REEP4 C8orf20 PP432	AAVQAATKSQGALAGRLRsFsMQDLRSISDAPAPAyHDPLy
Q9H788	S315	Sugiyama	SH2D4A PPP1R38 SH2A	LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H7D7	S121	Sugiyama	WDR26 CDW2 MIP2 PRO0852	ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9HAU0	S471	Sugiyama	PLEKHA5 KIAA1686 PEPP2	MARYPEGYRtLPRNSKTRPEsICSVtPsTHDKTLGPGAEEK
Q9HCD5	S378	Sugiyama	NCOA5 KIAA1637	EETDKIINYLRERKERLMRsstDsLPGPISRQPLGATSGAS
Q9NP61	S367	Sugiyama	ARFGAP3 ARFGAP1	DsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKDT
Q9NRA8	S353	Sugiyama	EIF4ENIF1	SASRFSRWFSNPsRsGsRsssLGstPHEELERLAGLEQAIL
Q9NSB2	S178	Sugiyama	KRT84 KRTHB4	AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9NTI5	S1257	Sugiyama	PDS5B APRIN AS3 KIAA0979	LVQEQKPKGSQRSRKRGHtAsEsDEQQWPEEKRLKEDILEN
Q9NUU7	T467	Sugiyama	DDX19A DDX19L	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9NVU7	T552	Sugiyama	SDAD1 NUC130	SMPMEERKAKAAAISTSRVLtQEDFQKIRMAQMRKELDAAP
Q9NVW2	T196	Sugiyama	RLIM RNF12	VENPRSESTSARPSRsERNstEALTEVPPTRGQRRARSRsP
Q9NYF8	S320	Sugiyama	BCLAF1 BTF KIAA0164	sPAKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRF
Q9NZN8	S242	Sugiyama	CNOT2 CDC36 NOT2 HSPC131 MSTP046	VTGLDLSDFPALADRNRREGsGNPtPLINPLAGRAPYVGMV
Q9P2N2	S69	Sugiyama	ARHGAP28 KIAA1314	RINRMLsNESLHPPAFsRSNsEASVDSASMEDFWREIESIK
Q9UBP6	S27	Sugiyama	METTL1 C12orf1	NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGV2	S331	Sugiyama	NDRG3	QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2	S338	Sugiyama	NDRG3	SASMTRLARsRtHstsssLGsGEsPFsRsVtsNQsDGtQES
Q9UGV2	T329	Sugiyama	NDRG3	FLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVts
Q9UHI6	T748	Sugiyama	DDX20 DP103 GEMIN3	SQRAKQSRRNLPRRSsFRLQtEAQEDDWyDCHREIRLSFSD
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKJ3	S890	Sugiyama	GPATCH8 GPATC8 KIAA0553	YSSSSDASSDQSCYSRQRSYsDDSYSDYSDRSRRHSKRSHD
Q9UKV3	S561	Sugiyama	ACIN1 ACINUS KIAA0670	GITEECLKQPsLEQKEGRRAsHtLLPSHRLKQSADSSSSRS
Q9UKV3	T563	Sugiyama	ACIN1 ACINUS KIAA0670	TEECLKQPsLEQKEGRRAsHtLLPSHRLKQSADSSSSRSSS
Q9ULD2	S1203	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	QENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRL
Q9ULD2	T1204	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	ENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRLs
Q9ULL1	S611	Sugiyama	PLEKHG1 KIAA1209	GQMESTETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTREL
Q9UMR2	T468	Sugiyama	DDX19B DBP5 DDX19 TDBP	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UNE7	S149	Sugiyama	STUB1 CHIP PP1131	LNFGDDIPsALRIAKKKRWNsIEERRIHQESELHSYLSRLI
Q9UNF1	S264	Sugiyama	MAGED2 BCG1	sLRsPKARRGKARRRAAKLQssQEPEAPPPRDVALLQGRAN
Q9UNF1	S265	Sugiyama	MAGED2 BCG1	LRsPKARRGKARRRAAKLQssQEPEAPPPRDVALLQGRAND
Q9UNH7	S316	Sugiyama	SNX6	LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UNN5	S582	Sugiyama	FAF1 UBXD12 UBXN3A CGI-03	PPEPKEENAEPVSKLRIRtPsGEFLERRFLASNKLQIVFDF
Q9UNZ2	S192	Sugiyama	NSFL1C UBXN2C	KRQHssQDVHVVLKLWKsGFsLDNGELRSyQDPsNAQFLEs
Q9UPQ0	S377	Sugiyama	LIMCH1 KIAA1102	LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ35	S1101	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sEsPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEF
Q9UQ35	S1539	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35	S1542	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDss
Q9Y2B0	S115	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7	S137	Sugiyama	YBX2 CSDA3 MSY2	EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA
Q9Y314	S36	Sugiyama	NOSIP CGI-25	YHEKKKDTAAsGYGtQNIRLsRDAVKDFDCCCLSLQPCHDP
Q9Y314	T30	Sugiyama	NOSIP CGI-25	AGAVyTYHEKKKDTAAsGYGtQNIRLsRDAVKDFDCCCLSL
Q9Y3U8	S91	Sugiyama	RPL36	KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y4C1	S264	PSP	KDM3A JHDM2A JMJD1 JMJD1A KIAA0742 TSGA	VHDNLVTCGNSARIGAVKRKssENNGTLVSKQAKsCsEAsP
Q9Y5S9	S56	Sugiyama	RBM8A RBM8 HSPC114 MDS014	KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y608	S18	Sugiyama	LRRFIP2	___MGTPASGRKRTPVKDRFsAEDEALsNIAREAEARLAAK

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
NRAGE signals death through JNK	R-HSA-193648	8.467467e-09	8.072	0	0
Chromatin modifying enzymes	R-HSA-3247509	7.950441e-08	7.100	0	0
G alpha (12/13) signalling events	R-HSA-416482	1.031795e-07	6.986	0	0
Signal Transduction	R-HSA-162582	2.183712e-07	6.661	1	0
Chromatin organization	R-HSA-4839726	2.616484e-07	6.582	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	2.997731e-07	6.523	0	0
Cell Cycle Checkpoints	R-HSA-69620	3.816364e-07	6.418	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	2.210719e-06	5.655	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	3.258874e-06	5.487	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	6.150664e-06	5.211	0	0
Cell Cycle	R-HSA-1640170	6.223797e-06	5.206	0	0
Regulation of TP53 Activity	R-HSA-5633007	1.586795e-05	4.799	0	0
Death Receptor Signaling	R-HSA-73887	1.551001e-05	4.809	0	0
Meiotic synapsis	R-HSA-1221632	2.137852e-05	4.670	0	0
HATs acetylate histones	R-HSA-3214847	3.579334e-05	4.446	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	6.171547e-05	4.210	0	0
G2/M DNA damage checkpoint	R-HSA-69473	7.280003e-05	4.138	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	7.795780e-05	4.108	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	7.934281e-05	4.100	0	0
Cellular Senescence	R-HSA-2559583	9.454203e-05	4.024	0	0
Cell Cycle, Mitotic	R-HSA-69278	1.114068e-04	3.953	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.469549e-04	3.833	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.603506e-04	3.795	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	1.829124e-04	3.738	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.790763e-04	3.747	0	0
Intracellular signaling by second messengers	R-HSA-9006925	1.966056e-04	3.706	0	0
Packaging Of Telomere Ends	R-HSA-171306	2.133613e-04	3.671	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	2.134891e-04	3.671	0	0
Mitotic Prophase	R-HSA-68875	2.204907e-04	3.657	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	2.386003e-04	3.622	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.799657e-04	3.553	0	0
Nucleosome assembly	R-HSA-774815	2.799657e-04	3.553	0	0
M Phase	R-HSA-68886	3.279716e-04	3.484	0	0
DNA Double Strand Break Response	R-HSA-5693606	3.530435e-04	3.452	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	3.754047e-04	3.426	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	4.441792e-04	3.352	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.826890e-04	3.316	0	0
Activation of RAC1	R-HSA-428540	5.076780e-04	3.294	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	5.118659e-04	3.291	0	0
G2/M Checkpoints	R-HSA-69481	5.806849e-04	3.236	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.575872e-04	3.182	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	6.792320e-04	3.168	0	0
RET signaling	R-HSA-8853659	8.051990e-04	3.094	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	7.679948e-04	3.115	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	7.838864e-04	3.106	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	7.838864e-04	3.106	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	8.322008e-04	3.080	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	9.510479e-04	3.022	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	9.391985e-04	3.027	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.011752e-03	2.995	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.122145e-03	2.950	0	0
DNA methylation	R-HSA-5334118	1.202977e-03	2.920	0	0
Axon guidance	R-HSA-422475	1.234503e-03	2.909	1	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.319685e-03	2.880	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	1.285841e-03	2.891	0	0
PIP3 activates AKT signaling	R-HSA-1257604	1.422624e-03	2.847	0	0
Regulation of TP53 Expression	R-HSA-6804754	1.431727e-03	2.844	0	0
Signaling by Hippo	R-HSA-2028269	1.482835e-03	2.829	0	0
Signaling by ROBO receptors	R-HSA-376176	1.545290e-03	2.811	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.750015e-03	2.757	0	0
Diseases of programmed cell death	R-HSA-9645723	1.712793e-03	2.766	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	1.826009e-03	2.738	0	0
DCC mediated attractive signaling	R-HSA-418885	2.236185e-03	2.650	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	2.204485e-03	2.657	0	0
PKMTs methylate histone lysines	R-HSA-3214841	2.204485e-03	2.657	0	0
Meiosis	R-HSA-1500620	2.187339e-03	2.660	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	2.338248e-03	2.631	0	0
mRNA 3'-end processing	R-HSA-72187	2.695754e-03	2.569	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	2.695754e-03	2.569	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	2.746283e-03	2.561	0	0
Cleavage of the damaged purine	R-HSA-110331	2.790593e-03	2.554	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	2.892169e-03	2.539	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.892597e-03	2.539	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.078823e-03	2.512	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	3.087630e-03	2.510	0	0
MTOR signalling	R-HSA-165159	3.156658e-03	2.501	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	3.156658e-03	2.501	0	0
Depyrimidination	R-HSA-73928	3.156658e-03	2.501	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	3.171070e-03	2.499	0	0
Depurination	R-HSA-73927	3.362702e-03	2.473	0	0
Estrogen-dependent gene expression	R-HSA-9018519	3.444995e-03	2.463	0	0
Nervous system development	R-HSA-9675108	3.630310e-03	2.440	1	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.026594e-03	2.395	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	4.026594e-03	2.395	0	0
HDACs deacetylate histones	R-HSA-3214815	4.269355e-03	2.370	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	4.340106e-03	2.362	0	0
Netrin-1 signaling	R-HSA-373752	4.421620e-03	2.354	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	4.792541e-03	2.319	0	0
Ub-specific processing proteases	R-HSA-5689880	5.771096e-03	2.239	0	0
Reproduction	R-HSA-1474165	5.906301e-03	2.229	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	6.023823e-03	2.220	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	6.023823e-03	2.220	0	0
Apoptotic execution phase	R-HSA-75153	6.068888e-03	2.217	0	0
PRC2 methylates histones and DNA	R-HSA-212300	6.136007e-03	2.212	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	6.347559e-03	2.197	0	0
Post NMDA receptor activation events	R-HSA-438064	6.421195e-03	2.192	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.873872e-03	2.163	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	6.874489e-03	2.163	0	0
Assembly of the pre-replicative complex	R-HSA-68867	6.984244e-03	2.156	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	7.314695e-03	2.136	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	7.361713e-03	2.133	0	0
Gene expression (Transcription)	R-HSA-74160	8.157196e-03	2.088	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	8.175239e-03	2.087	0	0
Cell-extracellular matrix interactions	R-HSA-446353	8.286950e-03	2.082	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	8.457095e-03	2.073	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	8.502807e-03	2.070	0	0
Germ layer formation at gastrulation	R-HSA-9754189	8.734830e-03	2.059	0	0
Rap1 signalling	R-HSA-392517	8.734830e-03	2.059	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.067562e-02	1.972	0	0
Type I hemidesmosome assembly	R-HSA-446107	1.067562e-02	1.972	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.007586e-02	1.997	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	9.656595e-03	2.015	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	9.502518e-03	2.022	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	1.013476e-02	1.994	0	0
Amplification of signal from the kinetochores	R-HSA-141424	1.013476e-02	1.994	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.007586e-02	1.997	0	0
RNA Polymerase II Transcription	R-HSA-73857	1.052406e-02	1.978	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.012794e-02	1.994	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.065257e-02	1.973	0	0
Neurodegenerative Diseases	R-HSA-8863678	1.065257e-02	1.973	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	1.067562e-02	1.972	0	0
Cell junction organization	R-HSA-446728	1.044968e-02	1.981	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.067562e-02	1.972	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.054653e-02	1.977	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	1.074495e-02	1.969	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.074495e-02	1.969	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.101988e-02	1.958	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.242425e-02	1.906	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.175209e-02	1.930	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.154026e-02	1.938	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.241713e-02	1.906	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.241713e-02	1.906	0	0
Cell-Cell communication	R-HSA-1500931	1.178425e-02	1.929	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.302031e-02	1.885	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	1.330107e-02	1.876	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.330107e-02	1.876	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	1.363471e-02	1.865	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.369325e-02	1.863	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	1.409292e-02	1.851	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	1.584870e-02	1.800	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.554123e-02	1.809	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.578793e-02	1.802	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	1.573882e-02	1.803	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.475401e-02	1.831	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	1.501937e-02	1.823	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	1.519390e-02	1.818	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.635204e-02	1.786	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.657914e-02	1.780	0	0
Homology Directed Repair	R-HSA-5693538	1.689898e-02	1.772	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.691024e-02	1.772	0	0
Specification of primordial germ cells	R-HSA-9827857	1.717956e-02	1.765	0	0
Oncogenic MAPK signaling	R-HSA-6802957	1.742235e-02	1.759	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.766981e-02	1.753	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	1.780236e-02	1.750	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.807932e-02	1.743	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.974293e-02	1.705	0	0
mRNA Splicing	R-HSA-72172	1.989694e-02	1.701	0	0
Co-stimulation by CD28	R-HSA-389356	1.819095e-02	1.740	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.006598e-02	1.698	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	2.041151e-02	1.690	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.046646e-02	1.689	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.082180e-02	1.681	0	0
Regulation of KIT signaling	R-HSA-1433559	2.163052e-02	1.665	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	2.221322e-02	1.653	0	0
Mitotic Prometaphase	R-HSA-68877	2.261558e-02	1.646	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	2.270538e-02	1.644	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	2.400782e-02	1.620	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.492421e-02	1.603	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.537586e-02	1.596	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	2.584996e-02	1.588	0	0
Meiotic recombination	R-HSA-912446	2.623136e-02	1.581	0	0
RAF activation	R-HSA-5673000	2.655032e-02	1.576	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.854549e-02	1.544	1	1
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	2.994896e-02	1.524	0	0
FLT3 Signaling	R-HSA-9607240	3.051062e-02	1.516	0	0
RNA Polymerase I Transcription	R-HSA-73864	3.064137e-02	1.514	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	3.129851e-02	1.504	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.168134e-02	1.499	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	3.226620e-02	1.491	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	3.531564e-02	1.452	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	3.451999e-02	1.462	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	3.451999e-02	1.462	0	0
AURKA Activation by TPX2	R-HSA-8854518	3.370160e-02	1.472	0	0
Regulation of TP53 Degradation	R-HSA-6804757	3.488882e-02	1.457	0	0
Chromosome Maintenance	R-HSA-73886	3.542933e-02	1.451	0	0
Sema4D in semaphorin signaling	R-HSA-400685	3.359628e-02	1.474	0	0
Epigenetic regulation of gene expression	R-HSA-212165	3.324074e-02	1.478	0	0
DNA Replication Pre-Initiation	R-HSA-69002	3.476559e-02	1.459	0	0
Dopamine receptors	R-HSA-390651	3.531564e-02	1.452	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.280830e-02	1.484	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.504251e-02	1.455	0	0
Calmodulin induced events	R-HSA-111933	3.488882e-02	1.457	0	0
CaM pathway	R-HSA-111997	3.488882e-02	1.457	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	3.667565e-02	1.436	0	0
ESR-mediated signaling	R-HSA-8939211	3.710389e-02	1.431	0	0
Generic Transcription Pathway	R-HSA-212436	3.714377e-02	1.430	0	0
TRP channels	R-HSA-3295583	3.922169e-02	1.406	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.967631e-02	1.401	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	4.087387e-02	1.389	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	4.087387e-02	1.389	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	4.316831e-02	1.365	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	4.341580e-02	1.362	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	4.341580e-02	1.362	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	4.341580e-02	1.362	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	4.341580e-02	1.362	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	4.341580e-02	1.362	0	0
Deubiquitination	R-HSA-5688426	4.353193e-02	1.361	0	0
Defective pyroptosis	R-HSA-9710421	4.374822e-02	1.359	0	0
Signaling by EGFR	R-HSA-177929	4.499222e-02	1.347	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	4.987084e-02	1.302	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.151045e-02	1.288	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	5.151045e-02	1.288	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	5.151045e-02	1.288	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	5.151045e-02	1.288	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	4.555483e-02	1.341	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	4.555483e-02	1.341	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	4.812165e-02	1.318	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	4.716079e-02	1.326	0	0
Signaling by VEGF	R-HSA-194138	4.959296e-02	1.305	0	0
Autophagy	R-HSA-9612973	4.532127e-02	1.344	0	0
G2/M Transition	R-HSA-69275	5.109781e-02	1.292	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.151045e-02	1.288	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	4.681369e-02	1.330	1	0
mTORC1-mediated signalling	R-HSA-166208	5.163566e-02	1.287	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	5.177302e-02	1.286	0	0
Regulation of endogenous retroelements	R-HSA-9842860	5.290369e-02	1.277	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	5.332415e-02	1.273	0	0
DAG and IP3 signaling	R-HSA-1489509	5.449410e-02	1.264	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	5.538823e-02	1.257	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	5.538823e-02	1.257	0	0
Mitotic Anaphase	R-HSA-68882	5.568490e-02	1.254	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	5.589377e-02	1.253	0	0
Calcineurin activates NFAT	R-HSA-2025928	5.589377e-02	1.253	0	0
GP1b-IX-V activation signalling	R-HSA-430116	5.589377e-02	1.253	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	5.589377e-02	1.253	0	0
Signaling by WNT	R-HSA-195721	5.599701e-02	1.252	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	5.655779e-02	1.248	0	0
Mitotic G2-G2/M phases	R-HSA-453274	5.665294e-02	1.247	0	0
Ephrin signaling	R-HSA-3928664	5.829470e-02	1.234	0	0
PKA activation	R-HSA-163615	5.829470e-02	1.234	0	0
PKA activation in glucagon signalling	R-HSA-164378	5.829470e-02	1.234	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.838899e-02	1.234	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	6.497742e-02	1.187	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	6.581223e-02	1.182	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	6.047455e-02	1.218	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	6.047455e-02	1.218	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	6.047455e-02	1.218	0	0
snRNP Assembly	R-HSA-191859	5.991561e-02	1.222	0	0
Metabolism of non-coding RNA	R-HSA-194441	5.991561e-02	1.222	0	0
Signaling by RAS mutants	R-HSA-6802949	6.047455e-02	1.218	0	0
DARPP-32 events	R-HSA-180024	5.974015e-02	1.224	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	6.327635e-02	1.199	0	0
Macroautophagy	R-HSA-1632852	6.231171e-02	1.205	0	0
Rab regulation of trafficking	R-HSA-9007101	6.866895e-02	1.163	0	0
Deadenylation of mRNA	R-HSA-429947	6.895194e-02	1.161	0	0
Signaling by RAF1 mutants	R-HSA-9656223	7.034059e-02	1.153	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	7.034059e-02	1.153	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.034059e-02	1.153	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	7.034059e-02	1.153	0	0
Separation of Sister Chromatids	R-HSA-2467813	7.038256e-02	1.153	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	7.041374e-02	1.152	0	0
Tandem pore domain potassium channels	R-HSA-1296346	7.041374e-02	1.152	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	7.066690e-02	1.151	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	7.066690e-02	1.151	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	7.066690e-02	1.151	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	7.066690e-02	1.151	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	7.066690e-02	1.151	0	0
NGF-stimulated transcription	R-HSA-9031628	7.368767e-02	1.133	0	0
Glycolysis	R-HSA-70171	7.448065e-02	1.128	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.467602e-02	1.127	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	8.217017e-02	1.085	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	8.217017e-02	1.085	0	0
Potassium transport channels	R-HSA-1296067	8.217017e-02	1.085	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	8.666559e-02	1.062	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	8.666559e-02	1.062	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	8.666559e-02	1.062	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	8.666559e-02	1.062	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	7.764123e-02	1.110	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	7.764123e-02	1.110	0	0
Differentiation of T cells	R-HSA-9945266	9.153107e-02	1.038	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	9.153107e-02	1.038	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	9.153107e-02	1.038	0	0
Phosphorylation of the APC/C	R-HSA-176412	9.153107e-02	1.038	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	8.203850e-02	1.086	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	8.450193e-02	1.073	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	8.450193e-02	1.073	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.538402e-02	1.069	0	0
Downstream signal transduction	R-HSA-186763	7.658158e-02	1.116	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	8.708777e-02	1.060	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	8.574520e-02	1.067	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	7.876606e-02	1.104	0	0
HDMs demethylate histones	R-HSA-3214842	7.876606e-02	1.104	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.783888e-02	1.109	0	0
Ca-dependent events	R-HSA-111996	7.788399e-02	1.109	0	0
Semaphorin interactions	R-HSA-373755	8.450193e-02	1.073	0	0
Signaling by APC mutants	R-HSA-4839744	8.666559e-02	1.062	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	9.153107e-02	1.038	0	0
MAPK family signaling cascades	R-HSA-5683057	8.465108e-02	1.072	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	9.159016e-02	1.038	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	9.252940e-02	1.034	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	9.252940e-02	1.034	0	0
EPHB-mediated forward signaling	R-HSA-3928662	9.441765e-02	1.025	0	0
Signaling by NTRKs	R-HSA-166520	9.564584e-02	1.019	1	0
Integrin signaling	R-HSA-354192	9.599589e-02	1.018	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	9.599589e-02	1.018	0	0
Telomere Maintenance	R-HSA-157579	9.694434e-02	1.013	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.852955e-02	1.006	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	9.912577e-02	1.004	1	0
Drug resistance of PDGFR mutants	R-HSA-9674415	1.115746e-01	0.952	0	0
PDGFR mutants bind TKIs	R-HSA-9674428	1.115746e-01	0.952	0	0
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.115746e-01	0.952	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.115746e-01	0.952	0	0
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.115746e-01	0.952	0	0
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.115746e-01	0.952	0	0
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.115746e-01	0.952	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.115746e-01	0.952	0	0
Signaling by FGFR1 amplification mutants	R-HSA-1839120	1.190912e-01	0.924	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	1.190912e-01	0.924	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.190912e-01	0.924	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	1.167949e-01	0.933	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	1.167949e-01	0.933	0	0
SOS-mediated signalling	R-HSA-112412	1.167949e-01	0.933	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	1.167949e-01	0.933	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.045584e-01	0.981	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.239781e-01	0.907	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.239781e-01	0.907	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.228121e-01	0.911	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.045674e-01	0.981	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.006931e-01	0.997	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.006931e-01	0.997	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.006931e-01	0.997	0	0
HIV elongation arrest and recovery	R-HSA-167287	1.127830e-01	0.948	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	1.127830e-01	0.948	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.004705e-01	0.998	0	0
HIV Transcription Elongation	R-HSA-167169	1.105064e-01	0.957	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.105064e-01	0.957	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.105064e-01	0.957	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.064763e-01	0.973	0	0
Centrosome maturation	R-HSA-380287	1.221321e-01	0.913	0	0
MITF-M-dependent gene expression	R-HSA-9856651	1.055189e-01	0.977	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.143213e-01	0.942	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.143213e-01	0.942	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.143213e-01	0.942	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	1.179460e-01	0.928	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	1.062178e-01	0.974	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.179460e-01	0.928	0	0
Generation of second messenger molecules	R-HSA-202433	1.105064e-01	0.957	0	0
Signaling by FGFR in disease	R-HSA-1226099	1.141457e-01	0.943	0	0
Co-inhibition by PD-1	R-HSA-389948	9.931096e-02	1.003	0	0
Kinesins	R-HSA-983189	1.147015e-01	0.940	0	0
PLC beta mediated events	R-HSA-112043	1.235642e-01	0.908	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.045674e-01	0.981	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.153082e-01	0.938	0	0
Regulation of PTEN localization	R-HSA-8948747	1.167949e-01	0.933	0	0
Signaling by AMER1 mutants	R-HSA-4839748	1.045584e-01	0.981	0	0
Signaling by AXIN mutants	R-HSA-4839735	1.045584e-01	0.981	0	0
Protein ubiquitination	R-HSA-8852135	1.221321e-01	0.913	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.006931e-01	0.997	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.208944e-01	0.918	0	0
Signaling by ALK in cancer	R-HSA-9700206	1.208944e-01	0.918	0	0
Gene Silencing by RNA	R-HSA-211000	1.208944e-01	0.918	0	0
RAF/MAP kinase cascade	R-HSA-5673001	1.245640e-01	0.905	0	0
Signaling by Erythropoietin	R-HSA-9006335	1.255995e-01	0.901	0	0
Regulation of gene expression in beta cells	R-HSA-210745	1.255995e-01	0.901	0	0
Apoptosis	R-HSA-109581	1.298238e-01	0.887	0	0
PI Metabolism	R-HSA-1483255	1.301231e-01	0.886	0	0
MAP2K and MAPK activation	R-HSA-5674135	1.321785e-01	0.879	0	0
Heme signaling	R-HSA-9707616	1.328011e-01	0.877	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.329341e-01	0.876	1	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.331869e-01	0.876	0	0
Base Excision Repair	R-HSA-73884	1.348030e-01	0.870	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.391177e-01	0.857	0	0
Interleukin-37 signaling	R-HSA-9008059	1.391177e-01	0.857	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.400837e-01	0.854	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.400837e-01	0.854	0	0
Polo-like kinase mediated events	R-HSA-156711	1.400837e-01	0.854	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.400837e-01	0.854	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.400837e-01	0.854	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.401869e-01	0.853	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.408735e-01	0.851	0	0
Membrane Trafficking	R-HSA-199991	1.418121e-01	0.848	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.440670e-01	0.841	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.440670e-01	0.841	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	1.447931e-01	0.839	0	0
Maturation of nucleoprotein	R-HSA-9683610	1.447931e-01	0.839	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.487513e-01	0.828	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	2.107061e-01	0.676	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.107061e-01	0.676	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.107061e-01	0.676	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.107061e-01	0.676	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.107061e-01	0.676	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.107061e-01	0.676	0	0
Tandem pore domain halothane-inhibited K+ channel (THIK)	R-HSA-1299287	2.107061e-01	0.676	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.107061e-01	0.676	0	0
Regulation of gap junction activity	R-HSA-191650	1.592017e-01	0.798	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.592017e-01	0.798	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.592017e-01	0.798	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	2.987816e-01	0.525	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.987816e-01	0.525	0	0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.987816e-01	0.525	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	2.987816e-01	0.525	0	0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.987816e-01	0.525	0	0
Signaling by TCF7L2 mutants	R-HSA-5339700	2.987816e-01	0.525	0	0
MyD88 deficiency (TLR5)	R-HSA-5602680	2.987816e-01	0.525	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	2.987816e-01	0.525	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	2.987816e-01	0.525	0	0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.987816e-01	0.525	0	0
Intestinal infectious diseases	R-HSA-8942233	2.987816e-01	0.525	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.987816e-01	0.525	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.987816e-01	0.525	0	0
IRS activation	R-HSA-74713	2.013311e-01	0.696	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.013311e-01	0.696	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.013311e-01	0.696	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.712085e-01	0.766	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.445303e-01	0.612	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.445303e-01	0.612	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	2.445303e-01	0.612	0	0
Signaling by MAPK mutants	R-HSA-9652817	2.445303e-01	0.612	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	3.770335e-01	0.424	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	3.770335e-01	0.424	0	0
Interaction between PHLDA1 and AURKA	R-HSA-8854521	3.770335e-01	0.424	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	3.770335e-01	0.424	0	0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)	R-HSA-5619049	3.770335e-01	0.424	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	3.770335e-01	0.424	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	3.770335e-01	0.424	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	3.770335e-01	0.424	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.770335e-01	0.424	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.770335e-01	0.424	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	3.770335e-01	0.424	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	3.770335e-01	0.424	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	3.770335e-01	0.424	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	3.770335e-01	0.424	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	3.770335e-01	0.424	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	3.770335e-01	0.424	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.770335e-01	0.424	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.770335e-01	0.424	0	0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	3.770335e-01	0.424	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	3.770335e-01	0.424	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.770335e-01	0.424	0	0
Formation of apoptosome	R-HSA-111458	2.006809e-01	0.697	0	0
Regulation of the apoptosome activity	R-HSA-9627069	2.006809e-01	0.697	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	2.880366e-01	0.541	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	2.880366e-01	0.541	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	2.312260e-01	0.636	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	2.312260e-01	0.636	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.900216e-01	0.721	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.583461e-01	0.800	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.775164e-01	0.751	0	0
Co-inhibition by CTLA4	R-HSA-389513	1.775164e-01	0.751	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.141236e-01	0.669	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	2.625362e-01	0.581	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	2.625362e-01	0.581	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	3.312439e-01	0.480	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	3.312439e-01	0.480	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.312439e-01	0.480	0	0
Netrin mediated repulsion signals	R-HSA-418886	3.312439e-01	0.480	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.312439e-01	0.480	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.312439e-01	0.480	0	0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	3.312439e-01	0.480	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.312439e-01	0.480	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	4.465570e-01	0.350	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.465570e-01	0.350	0	0
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	4.465570e-01	0.350	0	0
IRAK4 deficiency (TLR5)	R-HSA-5603037	4.465570e-01	0.350	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.465570e-01	0.350	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.465570e-01	0.350	0	0
Invadopodia formation	R-HSA-8941237	4.465570e-01	0.350	0	0
Defective GCLC causes HAGGSD	R-HSA-5578999	4.465570e-01	0.350	0	0
MET activates PTPN11	R-HSA-8865999	4.465570e-01	0.350	0	0
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	4.465570e-01	0.350	0	0
TGFBR3 expression	R-HSA-9839394	1.650896e-01	0.782	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.975059e-01	0.704	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	2.390056e-01	0.622	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.390056e-01	0.622	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.533083e-01	0.814	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.533083e-01	0.814	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.943259e-01	0.531	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	2.943259e-01	0.531	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	2.943259e-01	0.531	0	0
Signaling by PDGFR in disease	R-HSA-9671555	2.182217e-01	0.661	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.998693e-01	0.699	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	2.645095e-01	0.578	0	0
FGFR1b ligand binding and activation	R-HSA-190370	3.736775e-01	0.428	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	3.736775e-01	0.428	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.736775e-01	0.428	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.835683e-01	0.736	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	1.835683e-01	0.736	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	2.395679e-01	0.621	0	0
Notch-HLH transcription pathway	R-HSA-350054	2.395679e-01	0.621	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.181914e-01	0.661	0	0
Formation of the Early Elongation Complex	R-HSA-113418	2.181914e-01	0.661	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	3.263339e-01	0.486	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	3.263339e-01	0.486	0	0
Interleukin receptor SHC signaling	R-HSA-912526	2.614475e-01	0.583	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	2.370505e-01	0.625	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.167735e-01	0.499	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	3.167735e-01	0.499	0	0
ARMS-mediated activation	R-HSA-170984	4.149723e-01	0.382	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	5.083253e-01	0.294	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.083253e-01	0.294	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	5.083253e-01	0.294	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	5.083253e-01	0.294	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.083253e-01	0.294	0	0
Defective CP causes aceruloplasminemia (ACERULOP)	R-HSA-5619060	5.083253e-01	0.294	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	5.083253e-01	0.294	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	1.917396e-01	0.717	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	3.064199e-01	0.514	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	3.064199e-01	0.514	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	3.064199e-01	0.514	0	0
Tight junction interactions	R-HSA-420029	3.064199e-01	0.514	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.432451e-01	0.464	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	3.432451e-01	0.464	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	3.432451e-01	0.464	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	3.432451e-01	0.464	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	3.432451e-01	0.464	0	0
Erythropoietin activates RAS	R-HSA-9027284	3.900908e-01	0.409	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	3.900908e-01	0.409	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	3.900908e-01	0.409	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	3.900908e-01	0.409	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	3.293231e-01	0.482	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	3.697643e-01	0.432	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.697643e-01	0.432	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.548542e-01	0.342	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.548542e-01	0.342	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.370779e-01	0.472	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	3.108273e-01	0.507	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	3.962085e-01	0.402	0	0
Transcription of the HIV genome	R-HSA-167172	2.926464e-01	0.534	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.640200e-01	0.578	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	3.785295e-01	0.422	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	4.931244e-01	0.307	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	4.931244e-01	0.307	0	0
Regulation of MITF-M dependent genes involved in invasion	R-HSA-9854909	5.632029e-01	0.249	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.632029e-01	0.249	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.632029e-01	0.249	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.632029e-01	0.249	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	5.632029e-01	0.249	0	0
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	5.632029e-01	0.249	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	5.632029e-01	0.249	0	0
Defective F9 activation	R-HSA-9673221	5.632029e-01	0.249	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.632029e-01	0.249	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.632029e-01	0.249	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.632029e-01	0.249	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.993110e-01	0.399	0	0
DAP12 signaling	R-HSA-2424491	4.216503e-01	0.375	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	4.823315e-01	0.317	0	0
Trafficking of AMPA receptors	R-HSA-399719	4.445109e-01	0.352	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.159206e-01	0.381	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	4.740186e-01	0.324	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.296458e-01	0.276	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.296458e-01	0.276	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	5.296458e-01	0.276	0	0
ERKs are inactivated	R-HSA-202670	5.296458e-01	0.276	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	4.302086e-01	0.366	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	5.116121e-01	0.291	0	0
GAB1 signalosome	R-HSA-180292	5.116121e-01	0.291	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	5.116121e-01	0.291	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	5.116121e-01	0.291	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	4.559106e-01	0.341	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	4.991418e-01	0.302	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	4.815004e-01	0.317	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	4.746442e-01	0.324	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	4.859398e-01	0.313	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	5.399907e-01	0.268	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	5.399907e-01	0.268	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	5.399907e-01	0.268	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	5.643322e-01	0.248	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	5.330609e-01	0.273	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	5.477249e-01	0.261	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	5.477249e-01	0.261	0	0
Regulation of RAS by GAPs	R-HSA-5658442	5.296839e-01	0.276	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	5.673954e-01	0.246	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	5.328310e-01	0.273	0	0
Telomere Extension By Telomerase	R-HSA-171319	5.710710e-01	0.243	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	5.710710e-01	0.243	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	5.710710e-01	0.243	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	5.971383e-01	0.224	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	5.971383e-01	0.224	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	5.971383e-01	0.224	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	5.650960e-01	0.248	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	5.748775e-01	0.240	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	5.823367e-01	0.235	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	5.937261e-01	0.226	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	5.937261e-01	0.226	0	0
Late endosomal microautophagy	R-HSA-9615710	5.937261e-01	0.226	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	5.950291e-01	0.225	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	3.155614e-01	0.501	0	0
FOXO-mediated transcription	R-HSA-9614085	1.647113e-01	0.783	0	0
RUNX2 regulates bone development	R-HSA-8941326	2.504548e-01	0.601	0	0
RNA Polymerase III Transcription	R-HSA-74158	3.993110e-01	0.399	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	3.755109e-01	0.425	0	0
Formation of definitive endoderm	R-HSA-9823730	5.673954e-01	0.246	0	0
MET promotes cell motility	R-HSA-8875878	2.863432e-01	0.543	0	0
Circadian clock	R-HSA-9909396	2.303410e-01	0.638	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	4.370427e-01	0.359	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	4.370427e-01	0.359	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	3.432451e-01	0.464	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	2.680293e-01	0.572	0	0
Prolonged ERK activation events	R-HSA-169893	2.141236e-01	0.669	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	2.904815e-01	0.537	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.815310e-01	0.741	0	0
p75NTR recruits signalling complexes	R-HSA-209543	5.643322e-01	0.248	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.597661e-01	0.797	0	0
Hedgehog 'off' state	R-HSA-5610787	1.733596e-01	0.761	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.815310e-01	0.741	0	0
Myogenesis	R-HSA-525793	1.821482e-01	0.740	0	0
FGFR1 ligand binding and activation	R-HSA-190242	5.116121e-01	0.291	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	5.969704e-01	0.224	0	0
Signaling by ERBB2	R-HSA-1227986	5.535351e-01	0.257	0	0
p75NTR signals via NF-kB	R-HSA-193639	1.900216e-01	0.721	0	0
Frs2-mediated activation	R-HSA-170968	3.263339e-01	0.486	0	0
Resolution of D-Loop Structures	R-HSA-5693537	5.114690e-01	0.291	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	4.857397e-01	0.314	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	1.712085e-01	0.766	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	2.904815e-01	0.537	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	2.282993e-01	0.641	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	4.894789e-01	0.310	0	0
Regulation of mitotic cell cycle	R-HSA-453276	3.355125e-01	0.474	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.355125e-01	0.474	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	3.442585e-01	0.463	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	1.712085e-01	0.766	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.312439e-01	0.480	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.681376e-01	0.774	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	2.645095e-01	0.578	0	0
Nuclear RNA decay	R-HSA-9930044	1.835683e-01	0.736	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.128059e-01	0.672	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.700747e-01	0.769	0	0
Regulation of CDH11 function	R-HSA-9762292	4.548542e-01	0.342	0	0
PI3K/AKT activation	R-HSA-198203	4.548542e-01	0.342	0	0
Stabilization of p53	R-HSA-69541	4.611966e-01	0.336	0	0
Signaling by FGFR1	R-HSA-5654736	4.859398e-01	0.313	0	0
Oncogene Induced Senescence	R-HSA-2559585	3.785295e-01	0.422	0	0
Apoptotic factor-mediated response	R-HSA-111471	5.116121e-01	0.291	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	3.577650e-01	0.446	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	1.650076e-01	0.782	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	3.108273e-01	0.507	0	0
Signaling by FGFR4	R-HSA-5654743	5.599236e-01	0.252	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	1.592017e-01	0.798	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.592017e-01	0.798	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	2.445303e-01	0.612	0	0
NF-kB is activated and signals survival	R-HSA-209560	2.625362e-01	0.581	0	0
Adrenoceptors	R-HSA-390696	3.736775e-01	0.428	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.736775e-01	0.428	0	0
Sodium/Proton exchangers	R-HSA-425986	3.736775e-01	0.428	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	2.001849e-01	0.699	0	0
TCR signaling	R-HSA-202403	2.042731e-01	0.690	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.755109e-01	0.425	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.632029e-01	0.249	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	5.643322e-01	0.248	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	5.477249e-01	0.261	0	0
Formation of axial mesoderm	R-HSA-9796292	5.971383e-01	0.224	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	4.736498e-01	0.325	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	4.311104e-01	0.365	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	3.293231e-01	0.482	0	0
Signaling by FGFR3	R-HSA-5654741	5.969704e-01	0.224	0	0
Signal attenuation	R-HSA-74749	2.006809e-01	0.697	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.880366e-01	0.541	0	0
Long-term potentiation	R-HSA-9620244	3.064199e-01	0.514	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.643322e-01	0.248	0	0
Interleukin-1 signaling	R-HSA-9020702	3.503118e-01	0.456	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	3.800332e-01	0.420	0	0
Signaling by PDGF	R-HSA-186797	4.467072e-01	0.350	0	0
Ion homeostasis	R-HSA-5578775	2.314741e-01	0.635	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	4.214482e-01	0.375	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	5.743000e-01	0.241	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	1.792148e-01	0.747	0	0
TNF signaling	R-HSA-75893	3.477230e-01	0.459	0	0
Signalling to ERKs	R-HSA-187687	3.785295e-01	0.422	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	5.352215e-01	0.271	0	0
Insulin receptor signalling cascade	R-HSA-74751	3.491811e-01	0.457	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	3.461545e-01	0.461	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.445303e-01	0.612	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	1.668587e-01	0.778	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.645095e-01	0.578	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	3.736775e-01	0.428	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	3.736775e-01	0.428	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.563810e-01	0.591	0	0
IRS-mediated signalling	R-HSA-112399	2.453666e-01	0.610	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	3.165308e-01	0.500	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	4.548542e-01	0.342	0	0
Formation of the posterior neural plate	R-HSA-9832991	4.931244e-01	0.307	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.632029e-01	0.249	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	2.900421e-01	0.538	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.991418e-01	0.302	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	5.399907e-01	0.268	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	4.754989e-01	0.323	1	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.277150e-01	0.278	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	5.295740e-01	0.276	0	0
FGFR1c ligand binding and activation	R-HSA-190373	5.971383e-01	0.224	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	5.937261e-01	0.226	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	5.882364e-01	0.230	1	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	4.754989e-01	0.323	1	0
Mitophagy	R-HSA-5205647	2.160687e-01	0.665	0	0
IGF1R signaling cascade	R-HSA-2428924	2.382230e-01	0.623	0	0
Triglyceride catabolism	R-HSA-163560	5.748775e-01	0.240	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	1.835683e-01	0.736	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.114690e-01	0.291	0	0
Signaling by SCF-KIT	R-HSA-1433557	1.558991e-01	0.807	0	0
Developmental Biology	R-HSA-1266738	4.496841e-01	0.347	1	0
Glycogen metabolism	R-HSA-8982491	1.977354e-01	0.704	0	0
Interleukin-2 signaling	R-HSA-9020558	4.931244e-01	0.307	0	0
Signaling by WNT in cancer	R-HSA-4791275	1.681376e-01	0.774	0	0
Selective autophagy	R-HSA-9663891	1.820813e-01	0.740	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	5.296458e-01	0.276	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	5.477249e-01	0.261	0	0
S Phase	R-HSA-69242	2.511664e-01	0.600	0	0
Signaling by Hedgehog	R-HSA-5358351	3.788920e-01	0.421	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	2.717128e-01	0.566	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.426067e-01	0.354	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	2.958650e-01	0.529	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	5.690152e-01	0.245	1	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	1.592017e-01	0.798	0	0
Lipophagy	R-HSA-9613354	1.712085e-01	0.766	0	0
Leukotriene receptors	R-HSA-391906	2.880366e-01	0.541	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	3.736775e-01	0.428	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	4.548542e-01	0.342	0	0
DNA strand elongation	R-HSA-69190	4.671410e-01	0.331	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	3.629473e-01	0.440	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	5.237311e-01	0.281	0	0
Degradation of CDH1	R-HSA-9766229	5.115640e-01	0.291	0	0
Cilium Assembly	R-HSA-5617833	5.049946e-01	0.297	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	5.689825e-01	0.245	1	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	5.256212e-01	0.279	1	0
Signaling by NODAL	R-HSA-1181150	5.673954e-01	0.246	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.514719e-01	0.600	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	5.256212e-01	0.279	1	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	5.256212e-01	0.279	1	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	1.900216e-01	0.721	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.625362e-01	0.581	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.421235e-01	0.466	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	4.467072e-01	0.350	0	0
DNA Replication	R-HSA-69306	1.686782e-01	0.773	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	4.351316e-01	0.361	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	3.312439e-01	0.480	0	0
Activation of ATR in response to replication stress	R-HSA-176187	3.165308e-01	0.500	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	3.056052e-01	0.515	0	0
Integration of energy metabolism	R-HSA-163685	4.471620e-01	0.350	0	0
EGFR downregulation	R-HSA-182971	1.533083e-01	0.814	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.894789e-01	0.310	0	0
Interleukin-1 family signaling	R-HSA-446652	3.653291e-01	0.437	0	0
Opioid Signalling	R-HSA-111885	3.875849e-01	0.412	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	4.740186e-01	0.324	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.937261e-01	0.226	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.493359e-01	0.260	1	0
Specification of the neural plate border	R-HSA-9834899	5.399907e-01	0.268	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	5.566519e-01	0.254	1	0
Signaling by MET	R-HSA-6806834	4.683142e-01	0.329	0	0
Neurexins and neuroligins	R-HSA-6794361	4.159206e-01	0.381	0	0
Metabolism of RNA	R-HSA-8953854	5.251281e-01	0.280	0	0
G0 and Early G1	R-HSA-1538133	4.671410e-01	0.331	0	0
Cardiac conduction	R-HSA-5576891	3.806220e-01	0.420	0	0
MTF1 activates gene expression	R-HSA-5660489	1.592017e-01	0.798	0	0
Unwinding of DNA	R-HSA-176974	1.712085e-01	0.766	0	0
Interleukin-33 signaling	R-HSA-9014843	3.770335e-01	0.424	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	2.006809e-01	0.697	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.141236e-01	0.669	0	0
MET interacts with TNS proteins	R-HSA-8875513	4.465570e-01	0.350	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.390056e-01	0.622	0	0
Signaling by LTK	R-HSA-9842663	2.943259e-01	0.531	0	0
Co-stimulation by ICOS	R-HSA-9927354	3.736775e-01	0.428	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.263339e-01	0.486	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.904815e-01	0.537	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	2.682359e-01	0.571	0	0
PI3K Cascade	R-HSA-109704	2.527700e-01	0.597	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	3.962085e-01	0.402	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	3.577650e-01	0.446	0	0
Disorders of Developmental Biology	R-HSA-9675151	4.522397e-01	0.345	0	0
Bicarbonate transporters	R-HSA-425381	4.931244e-01	0.307	0	0
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.632029e-01	0.249	0	0
Reelin signalling pathway	R-HSA-8866376	5.632029e-01	0.249	0	0
Programmed Cell Death	R-HSA-5357801	2.201553e-01	0.657	0	0
Switching of origins to a post-replicative state	R-HSA-69052	3.647350e-01	0.438	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.370427e-01	0.359	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	4.508330e-01	0.346	0	0
Cristae formation	R-HSA-8949613	5.477249e-01	0.261	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	5.971383e-01	0.224	0	0
Orc1 removal from chromatin	R-HSA-68949	5.650960e-01	0.248	0	0
MAP kinase activation	R-HSA-450294	5.698598e-01	0.244	1	0
Viral Messenger RNA Synthesis	R-HSA-168325	5.698598e-01	0.244	0	0
Platelet calcium homeostasis	R-HSA-418360	5.937261e-01	0.226	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	1.560270e-01	0.807	0	0
Protein-protein interactions at synapses	R-HSA-6794362	4.209708e-01	0.376	0	0
Cell-cell junction organization	R-HSA-421270	1.655646e-01	0.781	0	0
Adherens junctions interactions	R-HSA-418990	2.017860e-01	0.695	0	0
DNA Repair	R-HSA-73894	4.577204e-01	0.339	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	3.233367e-01	0.490	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	5.237311e-01	0.281	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	3.583251e-01	0.446	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	3.165308e-01	0.500	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	5.535351e-01	0.257	0	0
G-protein mediated events	R-HSA-112040	1.843379e-01	0.734	0	0
FLT3 signaling in disease	R-HSA-9682385	5.748775e-01	0.240	0	0
HIV Infection	R-HSA-162906	4.672250e-01	0.330	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	5.189600e-01	0.285	1	0
RMTs methylate histone arginines	R-HSA-3214858	5.786521e-01	0.238	0	0
HIV Life Cycle	R-HSA-162587	5.034143e-01	0.298	0	0
Cellular response to heat stress	R-HSA-3371556	4.311104e-01	0.365	0	0
Cardiogenesis	R-HSA-9733709	1.835683e-01	0.736	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	4.894789e-01	0.310	0	0
Interleukin-2 family signaling	R-HSA-451927	3.233367e-01	0.490	0	0
ISG15 antiviral mechanism	R-HSA-1169408	1.910893e-01	0.719	0	0
Signaling by TGFBR3	R-HSA-9839373	4.559106e-01	0.341	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	3.736775e-01	0.428	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	4.548542e-01	0.342	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	4.522397e-01	0.345	0	0
TBC/RABGAPs	R-HSA-8854214	3.990619e-01	0.399	0	0
tRNA processing in the nucleus	R-HSA-6784531	4.467072e-01	0.350	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.710710e-01	0.243	0	0
ERK/MAPK targets	R-HSA-198753	5.937711e-01	0.226	1	1
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.937261e-01	0.226	0	0
Ovarian tumor domain proteases	R-HSA-5689896	5.950291e-01	0.225	0	0
Host Interactions of HIV factors	R-HSA-162909	4.664388e-01	0.331	0	0
Signaling by ERBB4	R-HSA-1236394	2.693749e-01	0.570	0	0
Cellular responses to stress	R-HSA-2262752	5.100251e-01	0.292	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	1.666872e-01	0.778	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	5.357994e-01	0.271	0	0
Interleukin-1 processing	R-HSA-448706	1.712085e-01	0.766	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	2.445303e-01	0.612	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.995598e-01	0.700	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	5.083253e-01	0.294	0	0
Protein hydroxylation	R-HSA-9629569	3.432451e-01	0.464	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.224653e-01	0.374	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	4.406977e-01	0.356	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	4.209708e-01	0.376	0	0
GPER1 signaling	R-HSA-9634597	4.932068e-01	0.307	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	5.643322e-01	0.248	0	0
Disorders of Nervous System Development	R-HSA-9697154	5.643322e-01	0.248	0	0
Pervasive developmental disorders	R-HSA-9005895	5.643322e-01	0.248	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.998693e-01	0.699	0	0
Cellular responses to stimuli	R-HSA-8953897	4.402422e-01	0.356	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	4.548542e-01	0.342	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	4.149723e-01	0.382	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.971383e-01	0.224	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	5.937261e-01	0.226	1	0
HCMV Late Events	R-HSA-9610379	5.916373e-01	0.228	0	0
Kidney development	R-HSA-9830369	2.787046e-01	0.555	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.006809e-01	0.697	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	4.823315e-01	0.317	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	3.210725e-01	0.493	0	0
Breakdown of the nuclear lamina	R-HSA-352238	2.987816e-01	0.525	0	0
DSCAM interactions	R-HSA-376172	3.770335e-01	0.424	0	0
Synthesis of PI	R-HSA-1483226	2.312260e-01	0.636	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.390056e-01	0.622	0	0
Alpha-defensins	R-HSA-1462054	3.736775e-01	0.428	0	0
Syndecan interactions	R-HSA-3000170	2.614475e-01	0.583	0	0
Sensory perception of sour taste	R-HSA-9729555	5.083253e-01	0.294	0	0
LTC4-CYSLTR mediated IL4 production	R-HSA-9664535	4.548542e-01	0.342	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	2.937738e-01	0.532	0	0
Interleukin-36 pathway	R-HSA-9014826	5.632029e-01	0.249	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	4.823315e-01	0.317	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	5.937711e-01	0.226	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	5.969704e-01	0.224	0	0
Formation of the nephric duct	R-HSA-9830364	3.064199e-01	0.514	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	2.101784e-01	0.677	0	0
Nephrin family interactions	R-HSA-373753	5.673954e-01	0.246	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	3.962085e-01	0.402	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.823315e-01	0.317	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	3.697643e-01	0.432	0	0
Mismatch Repair	R-HSA-5358508	5.116121e-01	0.291	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.880366e-01	0.541	0	0
Maturation of nucleoprotein	R-HSA-9694631	1.583461e-01	0.800	0	0
Nuclear import of Rev protein	R-HSA-180746	2.160687e-01	0.665	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.785295e-01	0.422	0	0
Aquaporin-mediated transport	R-HSA-445717	4.302086e-01	0.366	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	2.425303e-01	0.615	0	0
The NLRP3 inflammasome	R-HSA-844456	5.399907e-01	0.268	0	0
Formation of the anterior neural plate	R-HSA-9823739	3.900908e-01	0.409	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	4.823315e-01	0.317	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	5.673954e-01	0.246	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	4.894789e-01	0.310	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.712085e-01	0.766	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	2.445303e-01	0.612	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	5.083253e-01	0.294	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	3.900908e-01	0.409	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	3.233367e-01	0.490	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	3.233367e-01	0.490	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.421235e-01	0.466	0	0
NrCAM interactions	R-HSA-447038	5.632029e-01	0.249	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	3.800332e-01	0.420	0	0
Stimuli-sensing channels	R-HSA-2672351	4.504169e-01	0.346	0	0
Polymerase switching	R-HSA-69091	5.643322e-01	0.248	0	0
Leading Strand Synthesis	R-HSA-69109	5.643322e-01	0.248	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	5.971383e-01	0.224	0	0
Amyloid fiber formation	R-HSA-977225	1.764837e-01	0.753	0	0
Nephron development	R-HSA-9831926	2.904815e-01	0.537	0	0
Interleukin-7 signaling	R-HSA-1266695	3.064199e-01	0.514	0	0
Regulation of beta-cell development	R-HSA-186712	5.369578e-01	0.270	0	0
Glucose metabolism	R-HSA-70326	1.534274e-01	0.814	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	3.583251e-01	0.446	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	5.937711e-01	0.226	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	5.191396e-01	0.285	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	4.149723e-01	0.382	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	4.149723e-01	0.382	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.863432e-01	0.543	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	5.632029e-01	0.249	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	4.559106e-01	0.341	0	0
Interleukin-15 signaling	R-HSA-8983432	5.643322e-01	0.248	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	3.047268e-01	0.516	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	3.370779e-01	0.472	0	0
Negative regulation of MET activity	R-HSA-6807004	5.673954e-01	0.246	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.237311e-01	0.281	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	2.407608e-01	0.618	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.962085e-01	0.402	0	0
PECAM1 interactions	R-HSA-210990	4.931244e-01	0.307	0	0
Mitochondrial biogenesis	R-HSA-1592230	5.849415e-01	0.233	0	0
OAS antiviral response	R-HSA-8983711	5.643322e-01	0.248	0	0
IRE1alpha activates chaperones	R-HSA-381070	3.126797e-01	0.505	0	0
HDL assembly	R-HSA-8963896	3.583251e-01	0.446	0	0
Platelet sensitization by LDL	R-HSA-432142	5.116121e-01	0.291	0	0
Signaling by Leptin	R-HSA-2586552	4.548542e-01	0.342	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	5.992369e-01	0.222	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	6.016721e-01	0.221	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.021696e-01	0.220	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	6.041729e-01	0.219	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	6.051371e-01	0.218	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	6.051371e-01	0.218	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.118557e-01	0.213	0	0
PKB-mediated events	R-HSA-109703	6.119584e-01	0.213	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.119584e-01	0.213	0	0
Cam-PDE 1 activation	R-HSA-111957	6.119584e-01	0.213	0	0
PDE3B signalling	R-HSA-165160	6.119584e-01	0.213	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.119584e-01	0.213	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.119584e-01	0.213	0	0
Signaling by RNF43 mutants	R-HSA-5340588	6.119584e-01	0.213	0	0
Defective CSF2RA causes SMDP4	R-HSA-5688890	6.119584e-01	0.213	0	0
Defective CSF2RB causes SMDP5	R-HSA-5688849	6.119584e-01	0.213	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.119584e-01	0.213	0	0
Pentose phosphate pathway disease	R-HSA-6791465	6.119584e-01	0.213	0	0
Formation of the Editosome	R-HSA-75094	6.119584e-01	0.213	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	6.119584e-01	0.213	0	0
Phosphorylation of Emi1	R-HSA-176417	6.119584e-01	0.213	0	0
Synthesis of PS	R-HSA-1483101	6.119584e-01	0.213	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.119584e-01	0.213	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.119584e-01	0.213	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	6.119584e-01	0.213	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	6.119584e-01	0.213	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.119584e-01	0.213	0	0
Diseases of DNA repair	R-HSA-9675135	6.148549e-01	0.211	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	6.156549e-01	0.211	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	6.156549e-01	0.211	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	6.156549e-01	0.211	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	6.156549e-01	0.211	0	0
Activation of the pre-replicative complex	R-HSA-68962	6.156549e-01	0.211	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	6.156549e-01	0.211	0	0
Activation of BH3-only proteins	R-HSA-114452	6.156549e-01	0.211	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	6.157769e-01	0.211	0	0
Neuronal System	R-HSA-112316	6.158699e-01	0.211	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.168805e-01	0.210	1	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	6.190784e-01	0.208	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.190784e-01	0.208	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	6.190784e-01	0.208	0	0
Transmission across Chemical Synapses	R-HSA-112315	6.205032e-01	0.207	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	6.280516e-01	0.202	0	0
Removal of the Flap Intermediate	R-HSA-69166	6.280516e-01	0.202	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	6.280516e-01	0.202	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	6.280516e-01	0.202	0	0
CRMPs in Sema3A signaling	R-HSA-399956	6.280516e-01	0.202	0	0
Signal regulatory protein family interactions	R-HSA-391160	6.280516e-01	0.202	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	6.319396e-01	0.199	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	6.322851e-01	0.199	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	6.336750e-01	0.198	0	0
Signaling by ALK	R-HSA-201556	6.336750e-01	0.198	0	0
Muscle contraction	R-HSA-397014	6.356868e-01	0.197	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	6.382590e-01	0.195	0	0
HCMV Early Events	R-HSA-9609690	6.399073e-01	0.194	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	6.432912e-01	0.192	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.432912e-01	0.192	0	0
FGFR2 alternative splicing	R-HSA-6803529	6.432912e-01	0.192	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	6.432912e-01	0.192	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	6.432912e-01	0.192	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.432912e-01	0.192	0	0
Signaling by KIT in disease	R-HSA-9669938	6.432912e-01	0.192	0	0
Regulation of CDH1 Function	R-HSA-9764561	6.477098e-01	0.189	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	6.492441e-01	0.188	0	0
Synthesis of DNA	R-HSA-69239	6.499072e-01	0.187	0	0
Aggrephagy	R-HSA-9646399	6.521259e-01	0.186	0	0
STAT5 Activation	R-HSA-9645135	6.552742e-01	0.184	0	0
Erythropoietin activates STAT5	R-HSA-9027283	6.552742e-01	0.184	0	0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	6.552742e-01	0.184	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.552742e-01	0.184	0	0
Defective CYP11A1 causes AICSR	R-HSA-5579026	6.552742e-01	0.184	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.552742e-01	0.184	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.552742e-01	0.184	0	0
Neurofascin interactions	R-HSA-447043	6.552742e-01	0.184	0	0
CREB phosphorylation	R-HSA-199920	6.552742e-01	0.184	1	1
NADPH regeneration	R-HSA-389542	6.552742e-01	0.184	0	0
Nef and signal transduction	R-HSA-164944	6.552742e-01	0.184	0	0
Lipid particle organization	R-HSA-8964572	6.552742e-01	0.184	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	6.570858e-01	0.182	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	6.570858e-01	0.182	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.570858e-01	0.182	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.570858e-01	0.182	0	0
Processive synthesis on the lagging strand	R-HSA-69183	6.570858e-01	0.182	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	6.570858e-01	0.182	0	0
Spry regulation of FGF signaling	R-HSA-1295596	6.570858e-01	0.182	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.570858e-01	0.182	0	0
Protein methylation	R-HSA-8876725	6.570858e-01	0.182	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.570858e-01	0.182	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	6.570858e-01	0.182	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	6.572319e-01	0.182	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.572319e-01	0.182	0	0
Eukaryotic Translation Elongation	R-HSA-156842	6.604047e-01	0.180	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	6.613531e-01	0.180	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	6.613531e-01	0.180	0	0
Adaptive Immune System	R-HSA-1280218	6.644192e-01	0.178	0	0
DNA Damage Bypass	R-HSA-73893	6.657175e-01	0.177	0	0
Formation of the ureteric bud	R-HSA-9830674	6.663954e-01	0.176	0	0
Carnitine shuttle	R-HSA-200425	6.663954e-01	0.176	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	6.663954e-01	0.176	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	6.699739e-01	0.174	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	6.724444e-01	0.172	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	6.755856e-01	0.170	0	0
Regulation of necroptotic cell death	R-HSA-5675482	6.768459e-01	0.170	0	0
G-protein beta:gamma signalling	R-HSA-397795	6.768459e-01	0.170	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	6.768459e-01	0.170	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	6.816941e-01	0.166	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.842754e-01	0.165	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.842754e-01	0.165	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	6.842754e-01	0.165	0	0
Negative regulation of FLT3	R-HSA-9706369	6.842754e-01	0.165	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	6.842754e-01	0.165	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	6.870474e-01	0.163	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	6.872081e-01	0.163	0	0
Translation of Structural Proteins	R-HSA-9683701	6.872081e-01	0.163	0	0
SARS-CoV-1 Infection	R-HSA-9678108	6.876004e-01	0.163	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	6.883873e-01	0.162	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	6.883873e-01	0.162	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	6.883873e-01	0.162	0	0
Plasma lipoprotein assembly	R-HSA-8963898	6.883873e-01	0.162	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	6.937571e-01	0.159	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.937571e-01	0.159	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.937571e-01	0.159	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.937571e-01	0.159	0	0
Disinhibition of SNARE formation	R-HSA-114516	6.937571e-01	0.159	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.937571e-01	0.159	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.937571e-01	0.159	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	6.937571e-01	0.159	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.937571e-01	0.159	0	0
Electron transport from NADPH to Ferredoxin	R-HSA-2395516	6.937571e-01	0.159	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.937571e-01	0.159	0	0
VLDL clearance	R-HSA-8964046	6.937571e-01	0.159	0	0
Ca2+ activated K+ channels	R-HSA-1296052	6.937571e-01	0.159	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.937571e-01	0.159	0	0
Glycoprotein hormones	R-HSA-209822	6.937571e-01	0.159	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.937571e-01	0.159	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	6.937571e-01	0.159	0	0
CHL1 interactions	R-HSA-447041	6.937571e-01	0.159	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.937571e-01	0.159	0	0
Striated Muscle Contraction	R-HSA-390522	6.956644e-01	0.158	0	0
Vpu mediated degradation of CD4	R-HSA-180534	6.956644e-01	0.158	0	0
HSF1-dependent transactivation	R-HSA-3371571	6.971655e-01	0.157	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	6.971655e-01	0.157	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.997590e-01	0.155	0	0
Sensory processing of sound	R-HSA-9659379	6.997590e-01	0.155	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.004624e-01	0.155	0	0
Interleukin-17 signaling	R-HSA-448424	7.026637e-01	0.153	1	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	7.038212e-01	0.153	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	7.042749e-01	0.152	1	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	7.042749e-01	0.152	1	0
Inositol phosphate metabolism	R-HSA-1483249	7.050017e-01	0.152	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	7.075222e-01	0.150	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	7.092723e-01	0.149	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	7.092723e-01	0.149	0	0
Acyl chain remodelling of PS	R-HSA-1482801	7.092723e-01	0.149	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	7.092723e-01	0.149	0	0
Peptide chain elongation	R-HSA-156902	7.095010e-01	0.149	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	7.096701e-01	0.149	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	7.096701e-01	0.149	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	7.096701e-01	0.149	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	7.096701e-01	0.149	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	7.096701e-01	0.149	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	7.096701e-01	0.149	0	0
Passive transport by Aquaporins	R-HSA-432047	7.096701e-01	0.149	0	0
Synthesis of PG	R-HSA-1483148	7.096701e-01	0.149	0	0
Response to metal ions	R-HSA-5660526	7.096701e-01	0.149	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	7.121255e-01	0.147	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	7.121255e-01	0.147	0	0
Signaling by FGFR2	R-HSA-5654738	7.121391e-01	0.147	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.121391e-01	0.147	0	0
Signaling by Interleukins	R-HSA-449147	7.131653e-01	0.147	1	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.136849e-01	0.146	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.136849e-01	0.146	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	7.136849e-01	0.146	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	7.198093e-01	0.143	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	7.203005e-01	0.142	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	7.265705e-01	0.139	0	0
RSK activation	R-HSA-444257	7.279461e-01	0.138	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.279461e-01	0.138	0	0
MET receptor recycling	R-HSA-8875656	7.279461e-01	0.138	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	7.279461e-01	0.138	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	7.279461e-01	0.138	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.279461e-01	0.138	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.279461e-01	0.138	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	7.279461e-01	0.138	0	0
Regulation by c-FLIP	R-HSA-3371378	7.279461e-01	0.138	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	7.279461e-01	0.138	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.279461e-01	0.138	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	7.279461e-01	0.138	0	0
Dimerization of procaspase-8	R-HSA-69416	7.279461e-01	0.138	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	7.279461e-01	0.138	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	7.279461e-01	0.138	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	7.282358e-01	0.138	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	7.290632e-01	0.137	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.290632e-01	0.137	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	7.309096e-01	0.136	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	7.309096e-01	0.136	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	7.309096e-01	0.136	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	7.309096e-01	0.136	0	0
Downstream TCR signaling	R-HSA-202424	7.323059e-01	0.135	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	7.333320e-01	0.135	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	7.333320e-01	0.135	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	7.333320e-01	0.135	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	7.333320e-01	0.135	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	7.333320e-01	0.135	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	7.337150e-01	0.134	1	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	7.337150e-01	0.134	1	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	7.351716e-01	0.134	0	0
DAP12 interactions	R-HSA-2172127	7.351716e-01	0.134	0	0
Amine ligand-binding receptors	R-HSA-375280	7.351716e-01	0.134	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	7.384314e-01	0.132	0	0
Signaling by FGFR	R-HSA-190236	7.400398e-01	0.131	0	0
Regulation of insulin secretion	R-HSA-422356	7.400398e-01	0.131	0	0
Ca2+ pathway	R-HSA-4086398	7.404484e-01	0.131	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	7.432518e-01	0.129	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	7.473447e-01	0.126	0	0
GPVI-mediated activation cascade	R-HSA-114604	7.473447e-01	0.126	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	7.474164e-01	0.126	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	7.477795e-01	0.126	0	0
PTEN Regulation	R-HSA-6807070	7.489394e-01	0.126	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	7.499103e-01	0.125	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	7.499103e-01	0.125	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	7.553312e-01	0.122	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	7.553312e-01	0.122	0	0
Tie2 Signaling	R-HSA-210993	7.553312e-01	0.122	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	7.553312e-01	0.122	0	0
Interleukin-21 signaling	R-HSA-9020958	7.583199e-01	0.120	0	0
WNT mediated activation of DVL	R-HSA-201688	7.583199e-01	0.120	0	0
CASP8 activity is inhibited	R-HSA-5218900	7.583199e-01	0.120	0	0
ALK mutants bind TKIs	R-HSA-9700645	7.583199e-01	0.120	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.583199e-01	0.120	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	7.583199e-01	0.120	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	7.583199e-01	0.120	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.583199e-01	0.120	0	0
p75NTR regulates axonogenesis	R-HSA-193697	7.583199e-01	0.120	0	0
Regulation of signaling by NODAL	R-HSA-1433617	7.583199e-01	0.120	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.583199e-01	0.120	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.583199e-01	0.120	0	0
mRNA Editing	R-HSA-75072	7.583199e-01	0.120	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	7.583199e-01	0.120	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	7.583199e-01	0.120	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.583199e-01	0.120	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.583199e-01	0.120	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	7.586369e-01	0.120	0	0
Degradation of DVL	R-HSA-4641258	7.630004e-01	0.117	0	0
Eukaryotic Translation Initiation	R-HSA-72613	7.636519e-01	0.117	0	0
Cap-dependent Translation Initiation	R-HSA-72737	7.636519e-01	0.117	0	0
Signaling by Insulin receptor	R-HSA-74752	7.642231e-01	0.117	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	7.654458e-01	0.116	0	0
Inflammasomes	R-HSA-622312	7.654458e-01	0.116	0	0
Pyroptosis	R-HSA-5620971	7.654458e-01	0.116	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.668118e-01	0.115	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.668118e-01	0.115	0	0
Potential therapeutics for SARS	R-HSA-9679191	7.720703e-01	0.112	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	7.742478e-01	0.111	0	0
Regulation of signaling by CBL	R-HSA-912631	7.757441e-01	0.110	0	0
STING mediated induction of host immune responses	R-HSA-1834941	7.757441e-01	0.110	0	0
Signaling by NOTCH	R-HSA-157118	7.771331e-01	0.110	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.775380e-01	0.109	0	0
Recycling pathway of L1	R-HSA-437239	7.775380e-01	0.109	1	1
RIPK1-mediated regulated necrosis	R-HSA-5213460	7.778899e-01	0.109	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.778899e-01	0.109	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	7.820912e-01	0.107	0	0
mRNA Capping	R-HSA-72086	7.820912e-01	0.107	0	0
Folding of actin by CCT/TriC	R-HSA-390450	7.853042e-01	0.105	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	7.853042e-01	0.105	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.853042e-01	0.105	0	0
Formation of intermediate mesoderm	R-HSA-9761174	7.853042e-01	0.105	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	7.853042e-01	0.105	0	0
Pexophagy	R-HSA-9664873	7.853042e-01	0.105	0	0
Maturation of spike protein	R-HSA-9683686	7.853042e-01	0.105	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	7.853042e-01	0.105	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	7.853042e-01	0.105	0	0
Peptide hormone biosynthesis	R-HSA-209952	7.853042e-01	0.105	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	7.853042e-01	0.105	0	0
Josephin domain DUBs	R-HSA-5689877	7.853042e-01	0.105	0	0
Metal ion SLC transporters	R-HSA-425410	7.904431e-01	0.102	0	0
Regulated Necrosis	R-HSA-5218859	7.930325e-01	0.101	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	7.933790e-01	0.101	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.946505e-01	0.100	0	0
Pregnenolone biosynthesis	R-HSA-196108	7.946505e-01	0.100	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	7.977483e-01	0.098	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	7.977483e-01	0.098	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.977483e-01	0.098	0	0
Extension of Telomeres	R-HSA-180786	8.024803e-01	0.096	0	0
Triglyceride metabolism	R-HSA-8979227	8.024803e-01	0.096	0	0
Eukaryotic Translation Termination	R-HSA-72764	8.024889e-01	0.096	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.036375e-01	0.095	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.054361e-01	0.094	0	0
Diseases of Immune System	R-HSA-5260271	8.054361e-01	0.094	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.054361e-01	0.094	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.054361e-01	0.094	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	8.092771e-01	0.092	0	0
LGI-ADAM interactions	R-HSA-5682910	8.092771e-01	0.092	0	0
FGFR2b ligand binding and activation	R-HSA-190377	8.092771e-01	0.092	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	8.092771e-01	0.092	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.092771e-01	0.092	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	8.092771e-01	0.092	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.092771e-01	0.092	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	8.092771e-01	0.092	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.092771e-01	0.092	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.092771e-01	0.092	0	0
Suppression of apoptosis	R-HSA-9635465	8.092771e-01	0.092	0	0
Transport of RCbl within the body	R-HSA-9758890	8.092771e-01	0.092	0	0
Prostanoid ligand receptors	R-HSA-391908	8.092771e-01	0.092	0	0
COPI-mediated anterograde transport	R-HSA-6807878	8.112982e-01	0.091	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	8.115539e-01	0.091	0	0
Vesicle-mediated transport	R-HSA-5653656	8.120957e-01	0.090	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	8.121323e-01	0.090	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	8.121323e-01	0.090	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	8.121323e-01	0.090	0	0
Lagging Strand Synthesis	R-HSA-69186	8.121323e-01	0.090	0	0
Signalling to RAS	R-HSA-167044	8.121323e-01	0.090	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.121323e-01	0.090	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.121323e-01	0.090	0	0
Basigin interactions	R-HSA-210991	8.121323e-01	0.090	0	0
Budding and maturation of HIV virion	R-HSA-162588	8.124522e-01	0.090	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	8.124522e-01	0.090	0	0
Ribosome-associated quality control	R-HSA-9948299	8.144154e-01	0.089	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.179093e-01	0.087	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	8.181314e-01	0.087	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.181314e-01	0.087	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	8.181314e-01	0.087	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	8.214922e-01	0.085	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.235913e-01	0.084	0	0
Hedgehog 'on' state	R-HSA-5632684	8.235913e-01	0.084	0	0
Formation of paraxial mesoderm	R-HSA-9793380	8.238073e-01	0.084	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.244358e-01	0.084	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	8.255703e-01	0.083	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.262402e-01	0.083	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	8.282719e-01	0.082	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	8.282719e-01	0.082	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	8.282719e-01	0.082	0	0
Attachment and Entry	R-HSA-9694614	8.282719e-01	0.082	0	0
Glutathione synthesis and recycling	R-HSA-174403	8.282719e-01	0.082	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.301365e-01	0.081	0	0
HIV Transcription Initiation	R-HSA-167161	8.301365e-01	0.081	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.301365e-01	0.081	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.301365e-01	0.081	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.301365e-01	0.081	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.301365e-01	0.081	0	0
Intra-Golgi traffic	R-HSA-6811438	8.301365e-01	0.081	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.301365e-01	0.081	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	8.305743e-01	0.081	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.305743e-01	0.081	0	0
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.305743e-01	0.081	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	8.305743e-01	0.081	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	8.305743e-01	0.081	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.305743e-01	0.081	0	0
Sodium/Calcium exchangers	R-HSA-425561	8.305743e-01	0.081	0	0
Uptake of dietary cobalamins into enterocytes	R-HSA-9758881	8.305743e-01	0.081	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.305743e-01	0.081	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	8.414745e-01	0.075	0	0
G1/S Transition	R-HSA-69206	8.426118e-01	0.074	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	8.431510e-01	0.074	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	8.431510e-01	0.074	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	8.431510e-01	0.074	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	8.431510e-01	0.074	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	8.431510e-01	0.074	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	8.432619e-01	0.074	0	0
Signaling by PTK6	R-HSA-8848021	8.432619e-01	0.074	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	8.432619e-01	0.074	0	0
Amino acids regulate mTORC1	R-HSA-9639288	8.463531e-01	0.072	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.463531e-01	0.072	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	8.494945e-01	0.071	0	0
GRB2 events in EGFR signaling	R-HSA-179812	8.494945e-01	0.071	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	8.494945e-01	0.071	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	8.494945e-01	0.071	0	0
Scavenging by Class F Receptors	R-HSA-3000484	8.494945e-01	0.071	0	0
IRAK1 recruits IKK complex	R-HSA-937039	8.494945e-01	0.071	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.494945e-01	0.071	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	8.494945e-01	0.071	0	0
MET activates RAS signaling	R-HSA-8851805	8.494945e-01	0.071	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.494945e-01	0.071	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	8.494945e-01	0.071	0	0
Repression of WNT target genes	R-HSA-4641265	8.494945e-01	0.071	0	0
Diseases associated with surfactant metabolism	R-HSA-5687613	8.494945e-01	0.071	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	8.494945e-01	0.071	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.494945e-01	0.071	0	0
Estrogen biosynthesis	R-HSA-193144	8.494945e-01	0.071	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.494945e-01	0.071	0	0
Signaling by NOTCH4	R-HSA-9013694	8.504960e-01	0.070	0	0
Ion channel transport	R-HSA-983712	8.509604e-01	0.070	0	0
Selenocysteine synthesis	R-HSA-2408557	8.509606e-01	0.070	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	8.512234e-01	0.070	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	8.512234e-01	0.070	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.512234e-01	0.070	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	8.521691e-01	0.069	0	0
Translation initiation complex formation	R-HSA-72649	8.559146e-01	0.068	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.559146e-01	0.068	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.568497e-01	0.067	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.568497e-01	0.067	0	0
Growth hormone receptor signaling	R-HSA-982772	8.568497e-01	0.067	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	8.580471e-01	0.066	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	8.586924e-01	0.066	0	0
Cellular response to hypoxia	R-HSA-1234174	8.609356e-01	0.065	0	0
Toll-like Receptor Cascades	R-HSA-168898	8.614396e-01	0.065	1	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	8.620315e-01	0.064	0	0
Proteasome assembly	R-HSA-9907900	8.622451e-01	0.064	0	0
Dual Incision in GG-NER	R-HSA-5696400	8.624979e-01	0.064	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	8.636306e-01	0.064	0	0
Viral mRNA Translation	R-HSA-192823	8.648635e-01	0.063	0	0
FGFR2c ligand binding and activation	R-HSA-190375	8.663029e-01	0.062	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.663029e-01	0.062	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.663029e-01	0.062	0	0
FGFR4 ligand binding and activation	R-HSA-190322	8.663029e-01	0.062	0	0
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	8.663029e-01	0.062	0	0
Acetylcholine binding and downstream events	R-HSA-181431	8.663029e-01	0.062	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	8.663029e-01	0.062	0	0
Chylomicron remodeling	R-HSA-8963901	8.663029e-01	0.062	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	8.663029e-01	0.062	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.663029e-01	0.062	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	8.663029e-01	0.062	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	8.663029e-01	0.062	0	0
Processing of SMDT1	R-HSA-8949664	8.663029e-01	0.062	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	8.663029e-01	0.062	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	8.663029e-01	0.062	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	8.663029e-01	0.062	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.663029e-01	0.062	0	0
Interleukin-12 signaling	R-HSA-9020591	8.665187e-01	0.062	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	8.694461e-01	0.061	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	8.694461e-01	0.061	0	0
TNFs bind their physiological receptors	R-HSA-5669034	8.694461e-01	0.061	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	8.714154e-01	0.060	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.717273e-01	0.060	0	0
Fanconi Anemia Pathway	R-HSA-6783310	8.717273e-01	0.060	0	0
Somitogenesis	R-HSA-9824272	8.717273e-01	0.060	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	8.722990e-01	0.059	0	0
Regulation of Apoptosis	R-HSA-169911	8.730141e-01	0.059	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.735494e-01	0.059	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	8.735494e-01	0.059	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	8.737044e-01	0.059	0	0
Translation of Structural Proteins	R-HSA-9694635	8.739854e-01	0.058	0	0
HCMV Infection	R-HSA-9609646	8.771765e-01	0.057	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.806410e-01	0.055	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.806410e-01	0.055	0	0
Laminin interactions	R-HSA-3000157	8.810155e-01	0.055	0	0
PCP/CE pathway	R-HSA-4086400	8.811029e-01	0.055	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.812349e-01	0.055	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.812349e-01	0.055	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	8.812349e-01	0.055	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	8.812349e-01	0.055	0	0
FGFR3c ligand binding and activation	R-HSA-190372	8.812349e-01	0.055	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.812349e-01	0.055	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	8.812349e-01	0.055	0	0
cGMP effects	R-HSA-418457	8.812349e-01	0.055	0	0
Prolactin receptor signaling	R-HSA-1170546	8.812349e-01	0.055	0	0
Physiological factors	R-HSA-5578768	8.812349e-01	0.055	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	8.828116e-01	0.054	0	0
MHC class II antigen presentation	R-HSA-2132295	8.839877e-01	0.054	0	0
Potassium Channels	R-HSA-1296071	8.843602e-01	0.053	0	0
Adipogenesis	R-HSA-9843745	8.846257e-01	0.053	0	0
Parasitic Infection Pathways	R-HSA-9824443	8.882361e-01	0.051	0	0
Leishmania infection	R-HSA-9658195	8.882361e-01	0.051	0	0
Dual incision in TC-NER	R-HSA-6782135	8.893178e-01	0.051	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	8.893178e-01	0.051	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	8.903724e-01	0.050	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	8.905158e-01	0.050	0	0
Neutrophil degranulation	R-HSA-6798695	8.913060e-01	0.050	0	0
MET activates PTK2 signaling	R-HSA-8874081	8.916301e-01	0.050	0	0
Metalloprotease DUBs	R-HSA-5689901	8.916301e-01	0.050	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	8.916301e-01	0.050	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	8.916301e-01	0.050	0	0
Sphingolipid catabolism	R-HSA-9845614	8.916301e-01	0.050	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	8.919294e-01	0.050	0	0
Degradation of AXIN	R-HSA-4641257	8.919294e-01	0.050	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.945001e-01	0.048	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	8.945001e-01	0.048	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.945001e-01	0.048	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	8.945001e-01	0.048	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.945001e-01	0.048	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.945001e-01	0.048	0	0
Signaling by Activin	R-HSA-1502540	8.945001e-01	0.048	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	8.945001e-01	0.048	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	8.945001e-01	0.048	0	0
p38MAPK events	R-HSA-171007	8.945001e-01	0.048	0	0
Biotin transport and metabolism	R-HSA-196780	8.945001e-01	0.048	0	0
FGFR3 ligand binding and activation	R-HSA-190239	8.945001e-01	0.048	0	0
Protein lipoylation	R-HSA-9857492	8.945001e-01	0.048	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	8.945001e-01	0.048	0	0
DNA Damage Reversal	R-HSA-73942	8.945001e-01	0.048	0	0
Influenza Infection	R-HSA-168255	8.949730e-01	0.048	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.965470e-01	0.047	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.013588e-01	0.045	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.013588e-01	0.045	0	0
Signaling by BMP	R-HSA-201451	9.013588e-01	0.045	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	9.013588e-01	0.045	0	0
Insulin processing	R-HSA-264876	9.013588e-01	0.045	0	0
Phospholipid metabolism	R-HSA-1483257	9.040510e-01	0.044	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	9.042225e-01	0.044	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.062843e-01	0.043	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	9.062843e-01	0.043	0	0
Killing mechanisms	R-HSA-9664420	9.062843e-01	0.043	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	9.062843e-01	0.043	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	9.062843e-01	0.043	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	9.062843e-01	0.043	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	9.062843e-01	0.043	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.062843e-01	0.043	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	9.062843e-01	0.043	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	9.062843e-01	0.043	0	0
Attachment and Entry	R-HSA-9678110	9.062843e-01	0.043	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.082770e-01	0.042	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.082770e-01	0.042	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.118315e-01	0.040	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.140511e-01	0.039	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.158300e-01	0.038	1	1
G beta:gamma signalling through CDC42	R-HSA-8964616	9.167528e-01	0.038	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.167528e-01	0.038	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.167528e-01	0.038	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.167528e-01	0.038	0	0
Phase 2 - plateau phase	R-HSA-5576893	9.167528e-01	0.038	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.167528e-01	0.038	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.167528e-01	0.038	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.167528e-01	0.038	0	0
Coenzyme A biosynthesis	R-HSA-196783	9.167528e-01	0.038	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.167528e-01	0.038	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.167528e-01	0.038	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.168640e-01	0.038	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	9.184166e-01	0.037	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.184166e-01	0.037	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	9.207765e-01	0.036	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	9.223492e-01	0.035	0	0
Cellular response to starvation	R-HSA-9711097	9.243396e-01	0.034	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.258659e-01	0.033	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.260525e-01	0.033	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.260525e-01	0.033	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	9.260525e-01	0.033	0	0
Glycogen storage diseases	R-HSA-3229121	9.260525e-01	0.033	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	9.260525e-01	0.033	0	0
Catecholamine biosynthesis	R-HSA-209905	9.260525e-01	0.033	0	0
Choline catabolism	R-HSA-6798163	9.260525e-01	0.033	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.262621e-01	0.033	0	0
Ion transport by P-type ATPases	R-HSA-936837	9.268572e-01	0.033	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.268572e-01	0.033	0	0
Gastrulation	R-HSA-9758941	9.280102e-01	0.032	0	0
Leishmania phagocytosis	R-HSA-9664417	9.284563e-01	0.032	0	0
Parasite infection	R-HSA-9664407	9.284563e-01	0.032	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.284563e-01	0.032	0	0
Smooth Muscle Contraction	R-HSA-445355	9.292064e-01	0.032	0	0
UCH proteinases	R-HSA-5689603	9.310064e-01	0.031	0	0
Signaling by TGFB family members	R-HSA-9006936	9.311160e-01	0.031	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.326695e-01	0.030	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.326695e-01	0.030	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	9.326695e-01	0.030	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.326695e-01	0.030	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	9.343138e-01	0.030	0	0
Activated point mutants of FGFR2	R-HSA-2033519	9.343138e-01	0.030	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	9.343138e-01	0.030	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.343138e-01	0.030	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.343138e-01	0.030	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.344186e-01	0.029	0	0
Interleukin-12 family signaling	R-HSA-447115	9.354670e-01	0.029	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.354789e-01	0.029	0	0
Cellular response to chemical stress	R-HSA-9711123	9.358489e-01	0.029	0	0
G alpha (s) signalling events	R-HSA-418555	9.371245e-01	0.028	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	9.388788e-01	0.027	0	0
Paracetamol ADME	R-HSA-9753281	9.393476e-01	0.027	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.397814e-01	0.027	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.416526e-01	0.026	0	0
Pyrimidine biosynthesis	R-HSA-500753	9.416526e-01	0.026	0	0
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.416526e-01	0.026	0	0
Translesion Synthesis by POLH	R-HSA-110320	9.416526e-01	0.026	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	9.416526e-01	0.026	0	0
Diseases of hemostasis	R-HSA-9671793	9.416526e-01	0.026	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	9.416526e-01	0.026	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	9.416526e-01	0.026	0	0
Other interleukin signaling	R-HSA-449836	9.416526e-01	0.026	0	0
L1CAM interactions	R-HSA-373760	9.422512e-01	0.026	1	0
ER-Phagosome pathway	R-HSA-1236974	9.432353e-01	0.025	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.439057e-01	0.025	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.445416e-01	0.025	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	9.445416e-01	0.025	0	0
G1 Phase	R-HSA-69236	9.447354e-01	0.025	0	0
Cyclin D associated events in G1	R-HSA-69231	9.447354e-01	0.025	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.481718e-01	0.023	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.481718e-01	0.023	0	0
Glycogen synthesis	R-HSA-3322077	9.481718e-01	0.023	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	9.481718e-01	0.023	0	0
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.481718e-01	0.023	0	0
Signal transduction by L1	R-HSA-445144	9.481718e-01	0.023	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	9.497025e-01	0.022	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.497025e-01	0.022	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	9.497025e-01	0.022	0	0
Miscellaneous transport and binding events	R-HSA-5223345	9.497025e-01	0.022	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.520953e-01	0.021	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	9.535267e-01	0.021	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.535267e-01	0.021	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.535267e-01	0.021	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.539630e-01	0.020	0	0
FGFR2 ligand binding and activation	R-HSA-190241	9.539630e-01	0.020	0	0
G-protein activation	R-HSA-202040	9.539630e-01	0.020	0	0
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.539630e-01	0.020	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.539630e-01	0.020	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.539630e-01	0.020	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.539630e-01	0.020	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.544029e-01	0.020	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.544029e-01	0.020	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	9.544029e-01	0.020	0	0
Signal amplification	R-HSA-392518	9.544029e-01	0.020	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.545890e-01	0.020	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.557639e-01	0.020	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	9.560049e-01	0.020	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.572865e-01	0.019	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.574149e-01	0.019	0	0
SARS-CoV Infections	R-HSA-9679506	9.574852e-01	0.019	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.586812e-01	0.018	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	9.591074e-01	0.018	0	0
Assembly Of The HIV Virion	R-HSA-175474	9.591074e-01	0.018	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.591670e-01	0.018	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	9.591716e-01	0.018	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	9.591716e-01	0.018	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	9.591716e-01	0.018	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	9.591716e-01	0.018	0	0
GABA receptor activation	R-HSA-977443	9.591716e-01	0.018	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	9.591716e-01	0.018	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.591716e-01	0.018	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.598558e-01	0.018	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	9.609068e-01	0.017	1	0
Collagen formation	R-HSA-1474290	9.617888e-01	0.017	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.625730e-01	0.017	0	0
HSF1 activation	R-HSA-3371511	9.625730e-01	0.017	0	0
Glycosphingolipid transport	R-HSA-9845576	9.625730e-01	0.017	0	0
G1/S-Specific Transcription	R-HSA-69205	9.625730e-01	0.017	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.636772e-01	0.016	0	0
Ethanol oxidation	R-HSA-71384	9.636772e-01	0.016	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.636772e-01	0.016	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.636772e-01	0.016	0	0
LDL clearance	R-HSA-8964038	9.636772e-01	0.016	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	9.642828e-01	0.016	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	9.647975e-01	0.016	0	0
Mitochondrial protein import	R-HSA-1268020	9.652693e-01	0.015	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.661114e-01	0.015	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.661114e-01	0.015	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	9.661114e-01	0.015	0	0
SLC-mediated transport of organic cations	R-HSA-549127	9.661114e-01	0.015	0	0
Collagen chain trimerization	R-HSA-8948216	9.661114e-01	0.015	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.674467e-01	0.014	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.677365e-01	0.014	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.677365e-01	0.014	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.677365e-01	0.014	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.677365e-01	0.014	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.677365e-01	0.014	0	0
Biosynthesis of maresins	R-HSA-9018682	9.677365e-01	0.014	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.677365e-01	0.014	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	9.677365e-01	0.014	0	0
Platelet homeostasis	R-HSA-418346	9.681210e-01	0.014	0	0
Chaperonin-mediated protein folding	R-HSA-390466	9.700918e-01	0.013	0	0
The phototransduction cascade	R-HSA-2514856	9.701149e-01	0.013	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.701149e-01	0.013	0	0
CYP2E1 reactions	R-HSA-211999	9.713424e-01	0.013	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	9.713424e-01	0.013	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.713424e-01	0.013	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.713424e-01	0.013	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.713424e-01	0.013	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.713424e-01	0.013	0	0
SLC transporter disorders	R-HSA-5619102	9.714084e-01	0.013	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.720503e-01	0.012	0	0
SARS-CoV-2 Infection	R-HSA-9694516	9.732614e-01	0.012	0	0
ABC transporter disorders	R-HSA-5619084	9.741506e-01	0.011	0	0
Integrin cell surface interactions	R-HSA-216083	9.741506e-01	0.011	0	0
G protein gated Potassium channels	R-HSA-1296059	9.745455e-01	0.011	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.745455e-01	0.011	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	9.745455e-01	0.011	0	0
Alpha-oxidation of phytanate	R-HSA-389599	9.745455e-01	0.011	0	0
Attenuation phase	R-HSA-3371568	9.748974e-01	0.011	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.763815e-01	0.010	0	0
Neddylation	R-HSA-8951664	9.764242e-01	0.010	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.770024e-01	0.010	0	0
Maturation of spike protein	R-HSA-9694548	9.773025e-01	0.010	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.773908e-01	0.010	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.773908e-01	0.010	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.773908e-01	0.010	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	9.783336e-01	0.010	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.788492e-01	0.009	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.791703e-01	0.009	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.799181e-01	0.009	0	0
Triglyceride biosynthesis	R-HSA-75109	9.799181e-01	0.009	0	0
Synthesis of PE	R-HSA-1483213	9.799181e-01	0.009	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.799181e-01	0.009	0	0
Protein folding	R-HSA-391251	9.807660e-01	0.008	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.821631e-01	0.008	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.821631e-01	0.008	0	0
Pyrimidine salvage	R-HSA-73614	9.821631e-01	0.008	0	0
Defensins	R-HSA-1461973	9.832530e-01	0.007	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.835854e-01	0.007	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	9.838806e-01	0.007	0	0
Thyroxine biosynthesis	R-HSA-209968	9.841572e-01	0.007	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.841572e-01	0.007	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.841572e-01	0.007	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.841572e-01	0.007	0	0
Nucleotide Excision Repair	R-HSA-5696398	9.845972e-01	0.007	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.848193e-01	0.007	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.848761e-01	0.007	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	9.849270e-01	0.007	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.852325e-01	0.006	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	9.859285e-01	0.006	0	0
Neurotransmitter clearance	R-HSA-112311	9.859285e-01	0.006	0	0
tRNA Aminoacylation	R-HSA-379724	9.868477e-01	0.006	0	0
Metabolism of polyamines	R-HSA-351202	9.868477e-01	0.006	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.875018e-01	0.005	0	0
Cargo concentration in the ER	R-HSA-5694530	9.875018e-01	0.005	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.875018e-01	0.005	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.875018e-01	0.005	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.876215e-01	0.005	0	0
Collagen degradation	R-HSA-1442490	9.880158e-01	0.005	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.888793e-01	0.005	0	0
DAG1 glycosylations	R-HSA-8931838	9.888993e-01	0.005	0	0
HS-GAG degradation	R-HSA-2024096	9.888993e-01	0.005	0	0
Signaling by NOTCH1	R-HSA-1980143	9.893214e-01	0.005	0	0
Intraflagellar transport	R-HSA-5620924	9.899678e-01	0.004	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.905170e-01	0.004	0	0
Neurotransmitter release cycle	R-HSA-112310	9.908652e-01	0.004	0	0
Gap junction trafficking and regulation	R-HSA-157858	9.909521e-01	0.004	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.909521e-01	0.004	0	0
Interleukin-10 signaling	R-HSA-6783783	9.910304e-01	0.004	0	0
Glutamate and glutamine metabolism	R-HSA-8964539	9.912432e-01	0.004	0	0
Heme degradation	R-HSA-189483	9.912432e-01	0.004	0	0
PPARA activates gene expression	R-HSA-1989781	9.918609e-01	0.004	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.921626e-01	0.003	0	0
Signaling by NOTCH2	R-HSA-1980145	9.922225e-01	0.003	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.922225e-01	0.003	0	0
eNOS activation	R-HSA-203615	9.922225e-01	0.003	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.922225e-01	0.003	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.922225e-01	0.003	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.922225e-01	0.003	0	0
rRNA processing	R-HSA-72312	9.924293e-01	0.003	0	0
Complex IV assembly	R-HSA-9864848	9.926456e-01	0.003	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.928629e-01	0.003	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.928751e-01	0.003	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.930924e-01	0.003	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.930924e-01	0.003	0	0
PERK regulates gene expression	R-HSA-381042	9.930924e-01	0.003	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.930924e-01	0.003	0	0
Metabolism of steroid hormones	R-HSA-196071	9.931864e-01	0.003	0	0
Nicotinate metabolism	R-HSA-196807	9.931864e-01	0.003	0	0
GPCR downstream signalling	R-HSA-388396	9.932257e-01	0.003	0	0
RSV-host interactions	R-HSA-9833110	9.934771e-01	0.003	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.938048e-01	0.003	0	0
HS-GAG biosynthesis	R-HSA-2022928	9.938650e-01	0.003	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.938650e-01	0.003	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.939984e-01	0.003	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.940276e-01	0.003	0	0
NCAM1 interactions	R-HSA-419037	9.945512e-01	0.002	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.945512e-01	0.002	0	0
Lysine catabolism	R-HSA-71064	9.945512e-01	0.002	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.948826e-01	0.002	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.948826e-01	0.002	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.950136e-01	0.002	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.950136e-01	0.002	0	0
Signaling by NOTCH3	R-HSA-9012852	9.951540e-01	0.002	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.951607e-01	0.002	0	0
Purine salvage	R-HSA-74217	9.951607e-01	0.002	0	0
Elastic fibre formation	R-HSA-1566948	9.951607e-01	0.002	0	0
ECM proteoglycans	R-HSA-3000178	9.953509e-01	0.002	0	0
Metabolism of cofactors	R-HSA-8978934	9.953509e-01	0.002	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.956362e-01	0.002	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.957021e-01	0.002	0	0
Pentose phosphate pathway	R-HSA-71336	9.957021e-01	0.002	0	0
Plasma lipoprotein clearance	R-HSA-8964043	9.957021e-01	0.002	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.957021e-01	0.002	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.959708e-01	0.002	0	0
Dectin-2 family	R-HSA-5621480	9.960712e-01	0.002	0	0
Synthesis of PA	R-HSA-1483166	9.960712e-01	0.002	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	9.961829e-01	0.002	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.961829e-01	0.002	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.961829e-01	0.002	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.961829e-01	0.002	0	0
Tryptophan catabolism	R-HSA-71240	9.961829e-01	0.002	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.961829e-01	0.002	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.964635e-01	0.002	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.966100e-01	0.001	0	0
Aflatoxin activation and detoxification	R-HSA-5423646	9.966100e-01	0.001	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.966164e-01	0.001	0	0
Peroxisomal protein import	R-HSA-9033241	9.968172e-01	0.001	0	0
Iron uptake and transport	R-HSA-917937	9.968411e-01	0.001	0	0
RAB geranylgeranylation	R-HSA-8873719	9.971361e-01	0.001	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.971361e-01	0.001	0	0
Glutathione conjugation	R-HSA-156590	9.971361e-01	0.001	0	0
tRNA processing	R-HSA-72306	9.972387e-01	0.001	0	0
Interferon gamma signaling	R-HSA-877300	9.972433e-01	0.001	0	0
Activation of GABAB receptors	R-HSA-991365	9.973262e-01	0.001	0	0
GABA B receptor activation	R-HSA-977444	9.973262e-01	0.001	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.973262e-01	0.001	0	0
Nucleotide salvage	R-HSA-8956321	9.974235e-01	0.001	0	0
Pyrimidine catabolism	R-HSA-73621	9.976254e-01	0.001	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.976254e-01	0.001	0	0
Surfactant metabolism	R-HSA-5683826	9.978911e-01	0.001	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.978911e-01	0.001	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.981271e-01	0.001	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.981308e-01	0.001	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.982301e-01	0.001	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.983368e-01	0.001	0	0
Hemostasis	R-HSA-109582	9.983370e-01	0.001	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.984854e-01	0.001	0	0
Synthesis of PC	R-HSA-1483191	9.985229e-01	0.001	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.985906e-01	0.001	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.986883e-01	0.001	0	0
Gluconeogenesis	R-HSA-70263	9.986883e-01	0.001	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.987767e-01	0.001	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.988351e-01	0.001	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.989354e-01	0.000	0	0
Azathioprine ADME	R-HSA-9748787	9.989655e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.990258e-01	0.000	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.990813e-01	0.000	0	0
Retinoid metabolism and transport	R-HSA-975634	9.991131e-01	0.000	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.991386e-01	0.000	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.992034e-01	0.000	0	0
Viral Infection Pathways	R-HSA-9824446	9.992514e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.992847e-01	0.000	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.993577e-01	0.000	0	0
Protein localization	R-HSA-9609507	9.993641e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.993737e-01	0.000	0	0
G alpha (z) signalling events	R-HSA-418597	9.994287e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.994328e-01	0.000	0	0
G alpha (q) signalling events	R-HSA-416476	9.994579e-01	0.000	0	0
Digestion	R-HSA-8935690	9.994927e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.995831e-01	0.000	0	0
Cholesterol biosynthesis	R-HSA-191273	9.995831e-01	0.000	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.995914e-01	0.000	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.996259e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.996259e-01	0.000	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.996448e-01	0.000	0	0
PKR-mediated signaling	R-HSA-9833482	9.996644e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.996989e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.997064e-01	0.000	0	0
Endogenous sterols	R-HSA-211976	9.997199e-01	0.000	0	0
Developmental Cell Lineages	R-HSA-9734767	9.997391e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.997640e-01	0.000	0	0
Digestion and absorption	R-HSA-8963743	9.997791e-01	0.000	0	0
Platelet degranulation	R-HSA-114608	9.997933e-01	0.000	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.998039e-01	0.000	0	0
Xenobiotics	R-HSA-211981	9.998039e-01	0.000	0	0
Interferon Signaling	R-HSA-913531	9.998103e-01	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.998259e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.998359e-01	0.000	0	0
Pyruvate metabolism	R-HSA-70268	9.998596e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998627e-01	0.000	0	0
Immune System	R-HSA-168256	9.998686e-01	0.000	1	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.998849e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.999147e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.999242e-01	0.000	0	0
Formation of the cornified envelope	R-HSA-6809371	9.999321e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.999327e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999329e-01	0.000	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999470e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999571e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999581e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999581e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999625e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999632e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999664e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.999713e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999740e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999766e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999807e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999818e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999857e-01	0.000	1	0
Translation	R-HSA-72766	9.999897e-01	0.000	0	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999900e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999911e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999921e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999951e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999975e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.999979e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999981e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999994e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999995e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999995e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.999995e-01	0.000	0	0
Post-translational protein modification	R-HSA-597592	9.999995e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999995e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999997e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999998e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999999e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999999e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999999e-01	0.000	0	0
Disease	R-HSA-1643685	9.999999e-01	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000e+00	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	1.000000e+00	0.000	0	0
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000	0	0
Keratinization	R-HSA-6805567	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Cell Cycle	R-HSA-1640170	2.793654e-12	11.554	0	0
Cell Cycle, Mitotic	R-HSA-69278	1.004896e-11	10.998	0	0
Axon guidance	R-HSA-422475	6.414369e-11	10.193	1	0
Chromatin modifying enzymes	R-HSA-3247509	1.801710e-10	9.744	0	0
Cellular Senescence	R-HSA-2559583	1.733070e-10	9.761	0	0
Chromatin organization	R-HSA-4839726	2.031527e-10	9.692	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	2.725797e-10	9.565	0	0
Nervous system development	R-HSA-9675108	4.065340e-10	9.391	1	0
M Phase	R-HSA-68886	4.785994e-10	9.320	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	5.111626e-10	9.291	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.167593e-09	8.933	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.756884e-09	8.755	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.086890e-09	8.681	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	3.448128e-09	8.462	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	3.722444e-09	8.429	0	0
DNA Double Strand Break Response	R-HSA-5693606	5.028508e-09	8.299	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.935753e-09	8.100	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	8.397462e-09	8.076	0	0
HDACs deacetylate histones	R-HSA-3214815	1.501374e-08	7.824	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	2.196171e-08	7.658	0	0
Cell Cycle Checkpoints	R-HSA-69620	2.621607e-08	7.581	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	5.603323e-08	7.252	0	0
Assembly of the pre-replicative complex	R-HSA-68867	5.853959e-08	7.233	0	0
HATs acetylate histones	R-HSA-3214847	6.859218e-08	7.164	0	0
PRC2 methylates histones and DNA	R-HSA-212300	7.481556e-08	7.126	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	7.983042e-08	7.098	0	0
Cell-Cell communication	R-HSA-1500931	9.122304e-08	7.040	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.787329e-08	7.009	0	0
Signaling by ROBO receptors	R-HSA-376176	9.919553e-08	7.004	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.733320e-08	7.012	0	0
DNA methylation	R-HSA-5334118	1.225839e-07	6.912	0	0
mRNA Splicing	R-HSA-72172	1.273346e-07	6.895	0	0
Mitotic Prophase	R-HSA-68875	1.569082e-07	6.804	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.715704e-07	6.766	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.346114e-07	6.630	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	2.386122e-07	6.622	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.697271e-07	6.569	0	0
Apoptotic execution phase	R-HSA-75153	4.484800e-07	6.348	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	4.854833e-07	6.314	0	0
DNA Replication Pre-Initiation	R-HSA-69002	4.916428e-07	6.308	0	0
mRNA 3'-end processing	R-HSA-72187	5.175679e-07	6.286	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	5.085629e-07	6.294	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	6.113221e-07	6.214	0	0
Meiotic synapsis	R-HSA-1221632	6.650313e-07	6.177	0	0
Defective pyroptosis	R-HSA-9710421	8.534508e-07	6.069	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	9.056856e-07	6.043	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	9.320928e-07	6.031	0	0
Homology Directed Repair	R-HSA-5693538	9.769678e-07	6.010	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.105903e-06	5.956	0	0
Cell junction organization	R-HSA-446728	1.137905e-06	5.944	0	0
Regulation of endogenous retroelements	R-HSA-9842860	1.177095e-06	5.929	0	0
Cell-extracellular matrix interactions	R-HSA-446353	1.218021e-06	5.914	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	1.177095e-06	5.929	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	1.244104e-06	5.905	0	0
Nucleosome assembly	R-HSA-774815	1.454838e-06	5.837	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	1.454838e-06	5.837	0	0
G2/M DNA damage checkpoint	R-HSA-69473	1.400971e-06	5.854	0	0
Metabolism of RNA	R-HSA-8953854	1.535772e-06	5.814	0	0
G2/M Checkpoints	R-HSA-69481	1.549598e-06	5.810	0	0
Packaging Of Telomere Ends	R-HSA-171306	1.742656e-06	5.759	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.804570e-06	5.744	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	2.058072e-06	5.687	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.077216e-06	5.683	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.153786e-06	5.667	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.839501e-06	5.547	0	0
RNA Polymerase I Transcription	R-HSA-73864	3.040164e-06	5.517	0	0
Meiosis	R-HSA-1500620	3.396828e-06	5.469	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	3.602464e-06	5.443	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	4.129996e-06	5.384	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.085192e-06	5.294	0	0
Eukaryotic Translation Elongation	R-HSA-156842	5.158826e-06	5.287	0	0
Cap-dependent Translation Initiation	R-HSA-72737	5.657288e-06	5.247	0	0
Eukaryotic Translation Initiation	R-HSA-72613	5.657288e-06	5.247	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	6.278303e-06	5.202	0	0
Meiotic recombination	R-HSA-912446	6.226252e-06	5.206	0	0
Diseases of programmed cell death	R-HSA-9645723	6.771178e-06	5.169	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	6.864570e-06	5.163	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	6.864570e-06	5.163	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	7.312789e-06	5.136	0	0
Estrogen-dependent gene expression	R-HSA-9018519	6.933340e-06	5.159	0	0
Cleavage of the damaged purine	R-HSA-110331	1.014593e-05	4.994	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.123531e-05	4.949	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.296052e-05	4.887	0	0
Depurination	R-HSA-73927	1.313868e-05	4.881	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.633351e-05	4.787	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.943737e-05	4.711	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.952101e-05	4.709	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.952101e-05	4.709	0	0
Peptide chain elongation	R-HSA-156902	2.007929e-05	4.697	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.237705e-05	4.650	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	2.389632e-05	4.622	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	2.769275e-05	4.558	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	2.790652e-05	4.554	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.792518e-05	4.554	0	0
Mitotic Anaphase	R-HSA-68882	2.998058e-05	4.523	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.287942e-05	4.483	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	3.924791e-05	4.406	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	3.924791e-05	4.406	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	3.730368e-05	4.428	0	0
Signal Transduction	R-HSA-162582	3.672213e-05	4.435	1	0
Cellular responses to stress	R-HSA-2262752	3.901171e-05	4.409	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	4.122698e-05	4.385	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	4.631965e-05	4.334	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	4.631965e-05	4.334	0	0
Amyloid fiber formation	R-HSA-977225	4.826854e-05	4.316	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	5.120967e-05	4.291	0	0
Protein ubiquitination	R-HSA-8852135	5.453430e-05	4.263	0	0
DNA Replication	R-HSA-69306	5.699728e-05	4.244	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	5.408968e-05	4.267	0	0
Mitotic Prometaphase	R-HSA-68877	6.528414e-05	4.185	0	0
Chromosome Maintenance	R-HSA-73886	7.266327e-05	4.139	0	0
Separation of Sister Chromatids	R-HSA-2467813	7.908303e-05	4.102	0	0
Cellular responses to stimuli	R-HSA-8953897	7.994579e-05	4.097	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	8.708536e-05	4.060	0	0
PKMTs methylate histone lysines	R-HSA-3214841	1.022280e-04	3.990	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.533413e-05	4.021	0	0
Reproduction	R-HSA-1474165	1.079770e-04	3.967	0	0
Recycling pathway of L1	R-HSA-437239	1.216847e-04	3.915	1	1
Cleavage of the damaged pyrimidine	R-HSA-110329	1.549090e-04	3.810	0	0
Depyrimidination	R-HSA-73928	1.549090e-04	3.810	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	1.563049e-04	3.806	0	0
Gene Silencing by RNA	R-HSA-211000	1.573734e-04	3.803	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.625333e-04	3.789	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.749373e-04	3.757	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.787674e-04	3.748	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.327143e-04	3.633	0	0
Telomere Maintenance	R-HSA-157579	2.529427e-04	3.597	0	0
L1CAM interactions	R-HSA-373760	2.356512e-04	3.628	1	0
Aggrephagy	R-HSA-9646399	2.940726e-04	3.532	0	0
Apoptosis	R-HSA-109581	3.055450e-04	3.515	0	0
Death Receptor Signaling	R-HSA-73887	3.086124e-04	3.511	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	3.141705e-04	3.503	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	3.230946e-04	3.491	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.282449e-04	3.484	0	0
DNA Repair	R-HSA-73894	3.307773e-04	3.480	0	0
HCMV Early Events	R-HSA-9609690	3.612690e-04	3.442	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	4.424975e-04	3.354	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	4.248236e-04	3.372	0	0
Eukaryotic Translation Termination	R-HSA-72764	4.916823e-04	3.308	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	5.002203e-04	3.301	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.080222e-04	3.294	0	0
Adherens junctions interactions	R-HSA-418990	5.783504e-04	3.238	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	6.939876e-04	3.159	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	7.098821e-04	3.149	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	7.240612e-04	3.140	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	8.926660e-04	3.049	0	0
Cell-cell junction organization	R-HSA-421270	9.360782e-04	3.029	0	0
Epigenetic regulation of gene expression	R-HSA-212165	9.418291e-04	3.026	0	0
Selenocysteine synthesis	R-HSA-2408557	9.720190e-04	3.012	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.031794e-03	2.986	0	0
Kinesins	R-HSA-983189	1.064375e-03	2.973	0	0
Smooth Muscle Contraction	R-HSA-445355	1.066829e-03	2.972	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	1.098599e-03	2.959	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.099397e-03	2.959	0	0
ESR-mediated signaling	R-HSA-8939211	1.199653e-03	2.921	0	0
Viral mRNA Translation	R-HSA-192823	1.203563e-03	2.920	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	1.490955e-03	2.827	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	1.490955e-03	2.827	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.480823e-03	2.829	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	1.480823e-03	2.829	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.368507e-03	2.864	0	0
p75NTR signals via NF-kB	R-HSA-193639	1.490955e-03	2.827	0	0
Influenza Infection	R-HSA-168255	1.384610e-03	2.859	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	1.515723e-03	2.819	0	0
Autophagy	R-HSA-9612973	1.562299e-03	2.806	0	0
S Phase	R-HSA-69242	1.617341e-03	2.791	0	0
Nephrin family interactions	R-HSA-373753	1.700597e-03	2.769	0	0
Regulation of PTEN localization	R-HSA-8948747	1.920799e-03	2.717	0	0
NF-kB is activated and signals survival	R-HSA-209560	2.134413e-03	2.671	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	2.134413e-03	2.671	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	2.134413e-03	2.671	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.161484e-03	2.665	0	0
Selective autophagy	R-HSA-9663891	2.398279e-03	2.620	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	2.573868e-03	2.589	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	2.581506e-03	2.588	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.596472e-03	2.586	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	2.900619e-03	2.538	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	2.690977e-03	2.570	0	0
Ribosome-associated quality control	R-HSA-9948299	2.616880e-03	2.582	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	2.926768e-03	2.534	0	0
HCMV Infection	R-HSA-9609646	2.749345e-03	2.561	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.926768e-03	2.534	0	0
rRNA processing	R-HSA-72312	2.764482e-03	2.558	0	0
p75NTR recruits signalling complexes	R-HSA-209543	2.926768e-03	2.534	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	2.884897e-03	2.540	0	0
Base Excision Repair	R-HSA-73884	2.961602e-03	2.528	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	2.963939e-03	2.528	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	3.022665e-03	2.520	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	3.032604e-03	2.518	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	3.189228e-03	2.496	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.282157e-03	2.484	0	0
HIV Life Cycle	R-HSA-162587	3.287568e-03	2.483	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	3.388593e-03	2.470	0	0
Translation initiation complex formation	R-HSA-72649	3.391341e-03	2.470	0	0
Cellular response to starvation	R-HSA-9711097	3.541411e-03	2.451	0	0
Late endosomal microautophagy	R-HSA-9615710	3.842644e-03	2.415	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	3.920654e-03	2.407	0	0
Semaphorin interactions	R-HSA-373755	4.129505e-03	2.384	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	4.150047e-03	2.382	0	0
G2/M Transition	R-HSA-69275	4.263993e-03	2.370	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	4.367096e-03	2.360	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	4.396306e-03	2.357	0	0
Signaling by EGFR	R-HSA-177929	4.396306e-03	2.357	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	5.246466e-03	2.280	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	5.246466e-03	2.280	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	5.246466e-03	2.280	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	5.246466e-03	2.280	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	5.246466e-03	2.280	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	5.246466e-03	2.280	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	5.246466e-03	2.280	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	5.246466e-03	2.280	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	5.246466e-03	2.280	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	5.246466e-03	2.280	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	5.246466e-03	2.280	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	5.144658e-03	2.289	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	5.224233e-03	2.282	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	4.596425e-03	2.338	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	5.056998e-03	2.296	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	4.888418e-03	2.311	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	5.144658e-03	2.289	0	0
Signaling by WNT	R-HSA-195721	5.090579e-03	2.293	0	0
FLT3 signaling in disease	R-HSA-9682385	4.771631e-03	2.321	0	0
Mitotic G2-G2/M phases	R-HSA-453274	4.865275e-03	2.313	0	0
Programmed Cell Death	R-HSA-5357801	4.874416e-03	2.312	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	5.224233e-03	2.282	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	5.317244e-03	2.274	0	0
Maturation of protein E	R-HSA-9694493	5.405737e-03	2.267	0	0
Maturation of protein E	R-HSA-9683683	5.405737e-03	2.267	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	5.410318e-03	2.267	0	0
EGFR downregulation	R-HSA-182971	5.460484e-03	2.263	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	5.460484e-03	2.263	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	5.571086e-03	2.254	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	5.571086e-03	2.254	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	5.628420e-03	2.250	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	5.787245e-03	2.238	0	0
Josephin domain DUBs	R-HSA-5689877	5.787245e-03	2.238	0	0
Pexophagy	R-HSA-9664873	5.787245e-03	2.238	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	5.787245e-03	2.238	0	0
HDMs demethylate histones	R-HSA-3214842	6.108209e-03	2.214	0	0
Sema4D in semaphorin signaling	R-HSA-400685	6.108209e-03	2.214	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	6.296667e-03	2.201	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	6.426726e-03	2.192	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	6.581767e-03	2.182	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	6.581767e-03	2.182	0	0
Spry regulation of FGF signaling	R-HSA-1295596	6.627660e-03	2.179	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	6.627660e-03	2.179	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.821691e-03	2.107	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.057166e-03	2.094	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.057166e-03	2.094	0	0
Oncogenic MAPK signaling	R-HSA-6802957	8.038780e-03	2.095	0	0
Metalloprotease DUBs	R-HSA-5689901	7.317490e-03	2.136	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	8.098918e-03	2.092	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	8.398414e-03	2.076	0	0
Muscle contraction	R-HSA-397014	7.434210e-03	2.129	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.698829e-03	2.061	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	8.698829e-03	2.061	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	8.698829e-03	2.061	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	8.773923e-03	2.057	0	0
Signaling by ALK in cancer	R-HSA-9700206	8.773923e-03	2.057	0	0
Striated Muscle Contraction	R-HSA-390522	8.817437e-03	2.055	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	8.830240e-03	2.054	0	0
Amplification of signal from the kinetochores	R-HSA-141424	8.830240e-03	2.054	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	8.913086e-03	2.050	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	8.963105e-03	2.048	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	9.000882e-03	2.046	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	9.196737e-03	2.036	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	9.620419e-03	2.017	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	9.762796e-03	2.010	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	9.762796e-03	2.010	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	9.811709e-03	2.008	0	0
Membrane Trafficking	R-HSA-199991	9.871192e-03	2.006	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	9.932001e-03	2.003	0	0
Signaling by PTK6	R-HSA-8848021	9.932001e-03	2.003	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.048514e-02	1.979	0	0
Post NMDA receptor activation events	R-HSA-438064	1.059879e-02	1.975	0	0
TNF signaling	R-HSA-75893	1.089722e-02	1.963	0	0
HCMV Late Events	R-HSA-9610379	1.118535e-02	1.951	0	0
MAP2K and MAPK activation	R-HSA-5674135	1.124731e-02	1.949	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	1.154820e-02	1.937	0	0
Macroautophagy	R-HSA-1632852	1.189511e-02	1.925	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.203386e-02	1.920	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	1.291513e-02	1.889	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	1.291513e-02	1.889	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.319552e-02	1.880	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.319552e-02	1.880	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.319552e-02	1.880	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.319552e-02	1.880	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.319552e-02	1.880	0	0
VLDLR internalisation and degradation	R-HSA-8866427	1.328309e-02	1.877	0	0
Type I hemidesmosome assembly	R-HSA-446107	1.582121e-02	1.801	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.571442e-02	1.804	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.645039e-02	1.784	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.622455e-02	1.790	0	0
Signaling by ERBB2	R-HSA-1227986	1.667614e-02	1.778	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	1.335226e-02	1.874	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	1.561213e-02	1.807	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	1.561213e-02	1.807	0	0
Deubiquitination	R-HSA-5688426	1.625592e-02	1.789	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.357899e-02	1.867	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	1.448941e-02	1.839	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.494316e-02	1.826	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	1.582121e-02	1.801	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.582121e-02	1.801	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	1.582121e-02	1.801	0	0
Developmental Biology	R-HSA-1266738	1.404330e-02	1.853	1	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	1.571442e-02	1.804	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	1.571442e-02	1.804	0	0
Regulation of TP53 Activity	R-HSA-5633007	1.350785e-02	1.869	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	1.592731e-02	1.798	0	0
Modulation by Mtb of host immune system	R-HSA-9637628	1.582121e-02	1.801	0	0
Interleukin-12 signaling	R-HSA-9020591	1.606281e-02	1.794	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	1.692031e-02	1.772	0	0
EPH-Ephrin signaling	R-HSA-2682334	1.761984e-02	1.754	0	0
Ub-specific processing proteases	R-HSA-5689880	1.796017e-02	1.746	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.867449e-02	1.729	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.890742e-02	1.723	0	0
Regulation of signaling by CBL	R-HSA-912631	1.890742e-02	1.723	0	0
STING mediated induction of host immune responses	R-HSA-1834941	1.890742e-02	1.723	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	1.901676e-02	1.721	0	0
Signaling by NOTCH	R-HSA-157118	1.982315e-02	1.703	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	1.992924e-02	1.701	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	2.049313e-02	1.688	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	2.049313e-02	1.688	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	2.049313e-02	1.688	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	2.049313e-02	1.688	0	0
Signaling by RAS mutants	R-HSA-6802949	2.049313e-02	1.688	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.086467e-02	1.681	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	2.086467e-02	1.681	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	2.097232e-02	1.678	0	0
GP1b-IX-V activation signalling	R-HSA-430116	2.097232e-02	1.678	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.097232e-02	1.678	0	0
Unwinding of DNA	R-HSA-176974	2.097232e-02	1.678	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.137796e-02	1.670	0	0
Interleukin-12 family signaling	R-HSA-447115	2.169032e-02	1.664	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	2.239682e-02	1.650	0	0
Negative regulation of MET activity	R-HSA-6807004	2.251668e-02	1.647	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.328928e-02	1.633	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.431050e-02	1.614	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.434715e-02	1.614	0	0
NRAGE signals death through JNK	R-HSA-193648	2.512595e-02	1.600	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	2.553355e-02	1.593	0	0
DCC mediated attractive signaling	R-HSA-418885	2.553355e-02	1.593	0	0
Translesion synthesis by REV1	R-HSA-110312	2.553355e-02	1.593	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	2.553355e-02	1.593	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	3.266752e-02	1.486	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	3.266752e-02	1.486	0	0
Translesion synthesis by POLI	R-HSA-5656121	3.082255e-02	1.511	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	2.759356e-02	1.559	0	0
Signaling by RAF1 mutants	R-HSA-9656223	2.824515e-02	1.549	0	0
AURKA Activation by TPX2	R-HSA-8854518	2.930566e-02	1.533	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	3.415025e-02	1.467	0	0
Switching of origins to a post-replicative state	R-HSA-69052	2.580747e-02	1.588	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	2.968422e-02	1.527	0	0
UCH proteinases	R-HSA-5689603	3.302678e-02	1.481	0	0
Breakdown of the nuclear lamina	R-HSA-352238	2.806669e-02	1.552	0	0
Regulation of CDH1 Function	R-HSA-9764561	2.765884e-02	1.558	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	3.106327e-02	1.508	0	0
HIV Infection	R-HSA-162906	2.657975e-02	1.575	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.020284e-02	1.520	0	0
ISG15 antiviral mechanism	R-HSA-1169408	3.047581e-02	1.516	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	2.765884e-02	1.558	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.617443e-02	1.582	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	2.656261e-02	1.576	0	0
Negative regulation of FLT3	R-HSA-9706369	3.082255e-02	1.511	0	0
Assembly Of The HIV Virion	R-HSA-175474	3.106327e-02	1.508	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	3.106327e-02	1.508	0	0
HSF1 activation	R-HSA-3371511	3.496022e-02	1.456	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	3.603424e-02	1.443	0	0
Translesion synthesis by POLK	R-HSA-5655862	3.675129e-02	1.435	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	3.675129e-02	1.435	0	0
Orc1 removal from chromatin	R-HSA-68949	3.773654e-02	1.423	0	0
Activation of the pre-replicative complex	R-HSA-68962	3.842035e-02	1.415	0	0
RMTs methylate histone arginines	R-HSA-3214858	3.873656e-02	1.412	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	3.904652e-02	1.408	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.910032e-02	1.408	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	4.148847e-02	1.382	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.203860e-02	1.376	0	0
Fanconi Anemia Pathway	R-HSA-6783310	4.275333e-02	1.369	0	0
Signaling by Hippo	R-HSA-2028269	4.333416e-02	1.363	0	0
Budding and maturation of HIV virion	R-HSA-162588	4.335915e-02	1.363	0	0
Co-inhibition by PD-1	R-HSA-389948	4.351919e-02	1.361	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	4.628029e-02	1.335	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	4.680233e-02	1.330	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	4.680233e-02	1.330	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	4.704073e-02	1.328	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	4.718825e-02	1.326	0	0
Selenoamino acid metabolism	R-HSA-2408522	4.721968e-02	1.326	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	4.743617e-02	1.324	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.771168e-02	1.321	0	0
DNA strand elongation	R-HSA-69190	4.868997e-02	1.313	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.868997e-02	1.313	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	5.058031e-02	1.296	0	0
Ephrin signaling	R-HSA-3928664	5.058031e-02	1.296	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.069780e-02	1.295	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	5.098271e-02	1.293	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	5.098271e-02	1.293	0	0
IRAK1 recruits IKK complex	R-HSA-937039	5.098271e-02	1.293	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	5.098271e-02	1.293	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	5.343377e-02	1.272	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	5.365277e-02	1.270	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	5.365277e-02	1.270	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	5.388480e-02	1.269	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	5.388480e-02	1.269	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	5.441940e-02	1.264	0	0
Nuclear RNA decay	R-HSA-9930044	5.441940e-02	1.264	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	5.441940e-02	1.264	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	5.639157e-02	1.249	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	5.639157e-02	1.249	0	0
Synthesis of DNA	R-HSA-69239	5.670146e-02	1.246	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	5.849374e-02	1.233	0	0
Translesion Synthesis by POLH	R-HSA-110320	5.849374e-02	1.233	0	0
Rap1 signalling	R-HSA-392517	5.849374e-02	1.233	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.873601e-02	1.231	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	5.877428e-02	1.231	0	0
FLT3 Signaling	R-HSA-9607240	5.887068e-02	1.230	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.915365e-02	1.228	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	5.938026e-02	1.226	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	6.083905e-02	1.216	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	6.083905e-02	1.216	0	0
Hedgehog 'off' state	R-HSA-5610787	6.132257e-02	1.212	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	6.371750e-02	1.196	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	6.371750e-02	1.196	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	6.371750e-02	1.196	0	0
G1/S Transition	R-HSA-69206	6.371750e-02	1.196	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	6.464414e-02	1.189	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	6.464414e-02	1.189	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	6.640926e-02	1.178	0	0
Dual Incision in GG-NER	R-HSA-5696400	6.709200e-02	1.173	0	0
Mitophagy	R-HSA-5205647	6.709200e-02	1.173	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	6.709200e-02	1.173	0	0
Calnexin/calreticulin cycle	R-HSA-901042	6.709200e-02	1.173	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	6.709200e-02	1.173	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	6.794497e-02	1.168	1	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	9.508297e-02	1.022	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	9.508297e-02	1.022	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	1.031858e-01	0.986	0	0
PI3K/AKT activation	R-HSA-198203	1.031858e-01	0.986	0	0
2-LTR circle formation	R-HSA-164843	1.031858e-01	0.986	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	8.347829e-02	1.078	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	9.610992e-02	1.017	0	0
FGFR2 alternative splicing	R-HSA-6803529	9.673094e-02	1.014	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	7.626930e-02	1.118	0	0
HIV elongation arrest and recovery	R-HSA-167287	7.626930e-02	1.118	0	0
Formation of the Early Elongation Complex	R-HSA-113418	7.626930e-02	1.118	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	7.626930e-02	1.118	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	8.474102e-02	1.072	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.474102e-02	1.072	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	9.563969e-02	1.019	0	0
Nucleotide Excision Repair	R-HSA-5696398	8.601623e-02	1.065	0	0
EPHB-mediated forward signaling	R-HSA-3928662	8.400388e-02	1.076	0	0
mTORC1-mediated signalling	R-HSA-166208	9.673094e-02	1.014	0	0
G alpha (12/13) signalling events	R-HSA-416482	7.280758e-02	1.138	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	7.626930e-02	1.118	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.474102e-02	1.072	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.058833e-01	0.975	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	9.508297e-02	1.022	0	0
Prolonged ERK activation events	R-HSA-169893	9.610992e-02	1.017	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.474102e-02	1.072	0	0
Cyclin D associated events in G1	R-HSA-69231	8.400388e-02	1.076	0	0
G1 Phase	R-HSA-69236	8.400388e-02	1.076	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	9.370997e-02	1.028	0	0
Cellular response to heat stress	R-HSA-3371556	8.067336e-02	1.093	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	7.403983e-02	1.131	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.099602e-02	1.041	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	8.620441e-02	1.064	0	0
Oncogene Induced Senescence	R-HSA-2559585	7.403983e-02	1.131	0	0
Signaling by VEGF	R-HSA-194138	1.025938e-01	0.989	0	0
MTOR signalling	R-HSA-165159	7.075674e-02	1.150	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.408016e-02	1.075	0	0
Signaling by MET	R-HSA-6806834	8.276303e-02	1.082	0	0
Signaling by FGFR2	R-HSA-5654738	8.276303e-02	1.082	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	8.483666e-02	1.071	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	8.863739e-02	1.052	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	9.673094e-02	1.014	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	8.915741e-02	1.050	0	0
Gap junction trafficking	R-HSA-190828	8.400388e-02	1.076	0	0
Signaling by FGFR in disease	R-HSA-1226099	1.017593e-01	0.992	0	0
Regulation of TP53 Degradation	R-HSA-6804757	8.139560e-02	1.089	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	8.620441e-02	1.064	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.058833e-01	0.975	0	0
Plasma lipoprotein clearance	R-HSA-8964043	1.058833e-01	0.975	0	0
Viral Infection Pathways	R-HSA-9824446	7.743149e-02	1.111	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	7.075674e-02	1.150	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	9.610992e-02	1.017	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	7.178065e-02	1.144	0	0
IRE1alpha activates chaperones	R-HSA-381070	1.019653e-01	0.992	0	0
Regulation of BACH1 activity	R-HSA-9708530	9.610992e-02	1.017	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.064163e-01	0.973	0	0
Protein folding	R-HSA-391251	1.076425e-01	0.968	0	0
Centrosome maturation	R-HSA-380287	1.081043e-01	0.966	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.095785e-01	0.960	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.095785e-01	0.960	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.095785e-01	0.960	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	1.095785e-01	0.960	0	0
Platelet degranulation	R-HSA-114608	1.123049e-01	0.950	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	1.130573e-01	0.947	0	0
HIV Transcription Elongation	R-HSA-167169	1.148355e-01	0.940	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.148355e-01	0.940	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.148355e-01	0.940	0	0
Glycogen metabolism	R-HSA-8982491	1.148355e-01	0.940	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.151508e-01	0.939	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	1.196151e-01	0.922	1	1
Neurodegenerative Diseases	R-HSA-8863678	1.196151e-01	0.922	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.196151e-01	0.922	0	0
SARS-CoV-1 Infection	R-HSA-9678108	1.202378e-01	0.920	0	0
Dual incision in TC-NER	R-HSA-6782135	1.207892e-01	0.918	0	0
IRS activation	R-HSA-74713	1.225522e-01	0.912	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	1.225522e-01	0.912	0	0
DNA Damage Bypass	R-HSA-73893	1.230157e-01	0.910	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	1.230157e-01	0.910	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	1.230157e-01	0.910	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	1.230157e-01	0.910	0	0
Gap junction trafficking and regulation	R-HSA-157858	1.230157e-01	0.910	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.230157e-01	0.910	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	1.235041e-01	0.908	0	0
Regulation of necroptotic cell death	R-HSA-5675482	1.235041e-01	0.908	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	1.235041e-01	0.908	0	0
Activation of ATR in response to replication stress	R-HSA-176187	1.235041e-01	0.908	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.235041e-01	0.908	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.238372e-01	0.907	0	0
Specification of primordial germ cells	R-HSA-9827857	1.238372e-01	0.907	0	0
Glycogen storage diseases	R-HSA-3229121	1.238372e-01	0.907	0	0
PCP/CE pathway	R-HSA-4086400	1.284764e-01	0.891	0	0
Chaperonin-mediated protein folding	R-HSA-390466	1.307023e-01	0.884	0	0
Regulation of RAS by GAPs	R-HSA-5658442	1.317970e-01	0.880	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	1.338778e-01	0.873	0	0
Translation of Structural Proteins	R-HSA-9683701	1.338778e-01	0.873	0	0
GAB1 signalosome	R-HSA-180292	1.388345e-01	0.858	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	1.388345e-01	0.858	0	0
Activation of RAC1	R-HSA-428540	1.405453e-01	0.852	0	0
Integration of provirus	R-HSA-162592	1.405453e-01	0.852	0	0
Cilium Assembly	R-HSA-5617833	1.420966e-01	0.847	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	1.456390e-01	0.837	0	0
Gap junction assembly	R-HSA-190861	1.456390e-01	0.837	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	1.502860e-01	0.823	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	1.502860e-01	0.823	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	1.504970e-01	0.822	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	1.516422e-01	0.819	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.519522e-01	0.818	0	0
Signaling by FGFR	R-HSA-190236	1.524590e-01	0.817	0	0
Signaling by FGFR4	R-HSA-5654743	1.543670e-01	0.811	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.543670e-01	0.811	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	1.545154e-01	0.811	0	0
The NLRP3 inflammasome	R-HSA-844456	1.545154e-01	0.811	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	1.570990e-01	0.804	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	1.573378e-01	0.803	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.580447e-01	0.801	0	0
TICAM1 deficiency - HSE	R-HSA-5602566	1.580447e-01	0.801	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.580447e-01	0.801	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	1.581471e-01	0.801	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	1.581471e-01	0.801	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	1.581471e-01	0.801	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.581471e-01	0.801	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	1.581471e-01	0.801	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	1.599764e-01	0.796	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.606921e-01	0.794	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	1.606921e-01	0.794	0	0
Polymerase switching	R-HSA-69091	1.606921e-01	0.794	0	0
Leading Strand Synthesis	R-HSA-69109	1.606921e-01	0.794	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	1.606921e-01	0.794	0	0
Netrin-1 signaling	R-HSA-373752	1.651232e-01	0.782	0	0
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	2.274438e-01	0.643	0	0
Mitochondrial transcription initiation	R-HSA-163282	2.274438e-01	0.643	0	0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	R-HSA-5083628	2.274438e-01	0.643	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.274438e-01	0.643	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	2.274438e-01	0.643	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.274438e-01	0.643	0	0
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.274438e-01	0.643	0	0
TRAF3 deficiency - HSE	R-HSA-5602571	2.274438e-01	0.643	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	2.911264e-01	0.536	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	2.911264e-01	0.536	0	0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	R-HSA-5083629	2.911264e-01	0.536	0	0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	R-HSA-5083633	2.911264e-01	0.536	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	2.911264e-01	0.536	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	2.911264e-01	0.536	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	2.911264e-01	0.536	0	0
Erythropoietin activates STAT5	R-HSA-9027283	1.818996e-01	0.740	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	1.818996e-01	0.740	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	1.818996e-01	0.740	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	2.129348e-01	0.672	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	2.129348e-01	0.672	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	2.129348e-01	0.672	0	0
SOS-mediated signalling	R-HSA-112412	2.129348e-01	0.672	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.129348e-01	0.672	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	2.444144e-01	0.612	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	2.444144e-01	0.612	0	0
Formation of annular gap junctions	R-HSA-196025	2.444144e-01	0.612	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.444144e-01	0.612	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.816433e-01	0.741	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.816433e-01	0.741	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.032710e-01	0.692	0	0
ARMS-mediated activation	R-HSA-170984	2.760546e-01	0.559	0	0
Lipophagy	R-HSA-9613354	2.760546e-01	0.559	0	0
WNT mediated activation of DVL	R-HSA-201688	2.760546e-01	0.559	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	2.760546e-01	0.559	0	0
Gap junction degradation	R-HSA-190873	2.760546e-01	0.559	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.708221e-01	0.767	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.708221e-01	0.767	0	0
Erythropoietin activates RAS	R-HSA-9027284	2.254515e-01	0.647	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.254515e-01	0.647	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.254515e-01	0.647	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	3.076152e-01	0.512	0	0
Phosphorylation of the APC/C	R-HSA-176412	2.480660e-01	0.605	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.480660e-01	0.605	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.862902e-01	0.730	0	0
RET signaling	R-HSA-8853659	1.694315e-01	0.771	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.009972e-01	0.697	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	2.009972e-01	0.697	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.818987e-01	0.740	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	2.941528e-01	0.531	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	2.941528e-01	0.531	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	2.941528e-01	0.531	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	2.160800e-01	0.665	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	2.160800e-01	0.665	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	2.160800e-01	0.665	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.596261e-01	0.586	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.875877e-01	0.727	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	1.875877e-01	0.727	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	2.472250e-01	0.607	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	1.992648e-01	0.701	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	1.801995e-01	0.744	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	1.907100e-01	0.720	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.833390e-01	0.737	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	2.632297e-01	0.580	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	2.958315e-01	0.529	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	3.357956e-01	0.474	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	2.744625e-01	0.562	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	3.367851e-01	0.473	0	0
Transcription of the HIV genome	R-HSA-167172	2.123869e-01	0.673	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.350399e-01	0.629	0	0
Integrin signaling	R-HSA-354192	2.472250e-01	0.607	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	3.324508e-01	0.478	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	1.708221e-01	0.767	0	0
TGFBR3 expression	R-HSA-9839394	2.784160e-01	0.555	0	0
Degradation of DVL	R-HSA-4641258	1.818987e-01	0.740	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.350399e-01	0.629	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	2.922265e-01	0.534	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.069631e-01	0.513	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.254515e-01	0.647	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	2.490210e-01	0.604	0	0
Attenuation phase	R-HSA-3371568	2.213121e-01	0.655	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.350399e-01	0.629	0	0
Regulation of Apoptosis	R-HSA-169911	2.958315e-01	0.529	0	0
Resolution of D-Loop Structures	R-HSA-5693537	2.632125e-01	0.580	0	0
p75NTR regulates axonogenesis	R-HSA-193697	2.760546e-01	0.559	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	1.694315e-01	0.771	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.472250e-01	0.607	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	3.069631e-01	0.513	0	0
Transcription from mitochondrial promoters	R-HSA-75944	2.911264e-01	0.536	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	2.444144e-01	0.612	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	2.941528e-01	0.531	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.632297e-01	0.580	0	0
Signal transduction by L1	R-HSA-445144	1.708221e-01	0.767	0	0
Frs2-mediated activation	R-HSA-170968	1.816433e-01	0.741	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	2.334043e-01	0.632	0	0
Ovarian tumor domain proteases	R-HSA-5689896	3.290659e-01	0.483	0	0
Interleukin-1 signaling	R-HSA-9020702	2.618195e-01	0.582	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	2.410992e-01	0.618	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	2.567291e-01	0.591	1	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	2.137760e-01	0.670	1	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	2.567291e-01	0.591	1	0
Manipulation of host energy metabolism	R-HSA-9636667	2.274438e-01	0.643	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.274438e-01	0.643	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.274438e-01	0.643	0	0
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.274438e-01	0.643	0	0
Interleukin-33 signaling	R-HSA-9014843	2.911264e-01	0.536	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	1.816433e-01	0.741	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.816433e-01	0.741	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.480660e-01	0.605	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.947169e-01	0.711	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.213121e-01	0.655	0	0
Metabolism of non-coding RNA	R-HSA-194441	2.236917e-01	0.650	0	0
snRNP Assembly	R-HSA-191859	2.236917e-01	0.650	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	2.585684e-01	0.587	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	2.876789e-01	0.541	0	0
COPI-mediated anterograde transport	R-HSA-6807878	2.165057e-01	0.665	0	0
Host Interactions of HIV factors	R-HSA-162909	2.154593e-01	0.667	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	1.876948e-01	0.727	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	1.947169e-01	0.711	0	0
Protein methylation	R-HSA-8876725	2.254515e-01	0.647	0	0
Signaling by FGFR3	R-HSA-5654741	1.762019e-01	0.754	0	0
DNA Damage Reversal	R-HSA-73942	2.254515e-01	0.647	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	2.213121e-01	0.655	0	0
Signaling by FGFR1	R-HSA-5654736	1.907100e-01	0.720	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	2.904501e-01	0.537	0	0
Signal attenuation	R-HSA-74749	3.076152e-01	0.512	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	2.710018e-01	0.567	0	0
tRNA processing in the nucleus	R-HSA-6784531	2.585684e-01	0.587	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	3.010397e-01	0.521	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	2.533796e-01	0.596	0	0
NGF-stimulated transcription	R-HSA-9031628	2.112162e-01	0.675	0	0
Nef and signal transduction	R-HSA-164944	1.818996e-01	0.740	0	0
Protein hydroxylation	R-HSA-9629569	1.708221e-01	0.767	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	2.632125e-01	0.580	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	3.367851e-01	0.473	0	0
Vesicle-mediated transport	R-HSA-5653656	2.231168e-01	0.651	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.160800e-01	0.665	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	2.931242e-01	0.533	0	0
Maturation of spike protein	R-HSA-9683686	3.076152e-01	0.512	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.549813e-01	0.593	1	0
Gene expression (Transcription)	R-HSA-74160	2.461571e-01	0.609	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	1.875877e-01	0.727	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	2.705491e-01	0.568	0	0
Protein-protein interactions at synapses	R-HSA-6794362	2.828688e-01	0.548	0	0
Signaling by TGFB family members	R-HSA-9006936	2.770598e-01	0.557	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.760546e-01	0.559	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	2.760546e-01	0.559	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	2.760546e-01	0.559	0	0
Tandem pore domain potassium channels	R-HSA-1296346	3.076152e-01	0.512	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.410992e-01	0.618	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	2.078628e-01	0.682	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	2.351252e-01	0.629	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.517408e-01	0.599	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.254515e-01	0.647	0	0
Nuclear import of Rev protein	R-HSA-180746	2.794270e-01	0.554	0	0
Signaling by NOTCH1	R-HSA-1980143	1.925046e-01	0.716	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	2.551357e-01	0.593	0	0
MHC class II antigen presentation	R-HSA-2132295	2.078966e-01	0.682	0	0
Glycolysis	R-HSA-70171	2.524984e-01	0.598	0	0
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	2.911264e-01	0.536	0	0
Sodium/Proton exchangers	R-HSA-425986	2.444144e-01	0.612	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.076152e-01	0.512	0	0
Inflammasomes	R-HSA-622312	3.357956e-01	0.474	0	0
MAP kinase activation	R-HSA-450294	2.467555e-01	0.608	1	0
G1/S-Specific Transcription	R-HSA-69205	1.694315e-01	0.771	0	0
Signaling by ERBB4	R-HSA-1236394	1.743782e-01	0.759	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.129348e-01	0.672	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.444144e-01	0.612	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	2.760546e-01	0.559	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	2.050728e-01	0.688	0	0
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	1.876948e-01	0.727	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	3.082838e-01	0.511	0	0
Signaling by PDGFR in disease	R-HSA-9671555	2.050728e-01	0.688	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	2.160800e-01	0.665	0	0
MITF-M-dependent gene expression	R-HSA-9856651	2.834075e-01	0.548	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	1.876948e-01	0.727	0	0
Translation of Structural Proteins	R-HSA-9694635	3.119814e-01	0.506	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	1.876948e-01	0.727	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	2.776401e-01	0.557	0	0
Suppression of phagosomal maturation	R-HSA-9637687	2.974110e-01	0.527	0	0
Interleukin-7 signaling	R-HSA-1266695	2.784160e-01	0.555	0	0
Signaling by Leptin	R-HSA-2586552	3.076152e-01	0.512	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	2.737103e-01	0.563	0	0
Glycogen synthesis	R-HSA-3322077	1.708221e-01	0.767	0	0
Bicarbonate transporters	R-HSA-425381	3.388946e-01	0.470	0	0
PECAM1 interactions	R-HSA-210990	3.388946e-01	0.470	0	0
Stimuli-sensing channels	R-HSA-2672351	3.399652e-01	0.469	0	0
RAF/MAP kinase cascade	R-HSA-5673001	3.432843e-01	0.464	0	0
MET promotes cell motility	R-HSA-8875878	3.458254e-01	0.461	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.495630e-01	0.456	0	0
Axonal growth stimulation	R-HSA-209563	3.495630e-01	0.456	0	0
MET activates PTPN11	R-HSA-8865999	3.495630e-01	0.456	0	0
Invadopodia formation	R-HSA-8941237	3.495630e-01	0.456	0	0
FasL/ CD95L signaling	R-HSA-75157	3.495630e-01	0.456	0	0
MET interacts with TNS proteins	R-HSA-8875513	3.495630e-01	0.456	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	3.495630e-01	0.456	0	0
Intraflagellar transport	R-HSA-5620924	3.518207e-01	0.454	0	0
Metal ion SLC transporters	R-HSA-425410	3.518207e-01	0.454	0	0
MAPK family signaling cascades	R-HSA-5683057	3.544198e-01	0.450	0	0
Signaling by Erythropoietin	R-HSA-9006335	3.550801e-01	0.450	0	0
mRNA Capping	R-HSA-72086	3.550801e-01	0.450	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	3.550801e-01	0.450	0	0
Interleukin-17 signaling	R-HSA-448424	3.578641e-01	0.446	1	0
Signaling by NTRKs	R-HSA-166520	3.579559e-01	0.446	1	0
Signaling by Hedgehog	R-HSA-5358351	3.587412e-01	0.445	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	3.590978e-01	0.445	0	0
RNA Polymerase II Transcription	R-HSA-73857	3.601788e-01	0.443	0	0
TCR signaling	R-HSA-202403	3.602296e-01	0.443	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	3.626345e-01	0.441	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.693428e-01	0.433	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.693428e-01	0.433	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.693428e-01	0.433	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.693428e-01	0.433	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.693428e-01	0.433	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	3.697249e-01	0.432	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	3.697249e-01	0.432	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	3.697249e-01	0.432	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	3.697249e-01	0.432	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.697249e-01	0.432	0	0
Regulation of mitotic cell cycle	R-HSA-453276	3.706511e-01	0.431	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.706511e-01	0.431	0	0
Activation of BH3-only proteins	R-HSA-114452	3.743603e-01	0.427	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	3.794608e-01	0.421	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	3.794608e-01	0.421	0	0
PIP3 activates AKT signaling	R-HSA-1257604	3.814405e-01	0.419	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	3.831723e-01	0.417	0	0
Lagging Strand Synthesis	R-HSA-69186	3.870350e-01	0.412	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	3.870350e-01	0.412	0	0
Basigin interactions	R-HSA-210991	3.870350e-01	0.412	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	3.870350e-01	0.412	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	3.878777e-01	0.411	0	0
Intracellular signaling by second messengers	R-HSA-9006925	3.918896e-01	0.407	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	3.962730e-01	0.402	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	3.971366e-01	0.401	0	0
HSF1-dependent transactivation	R-HSA-3371571	3.971366e-01	0.401	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	3.999676e-01	0.398	0	0
Disorders of Nervous System Development	R-HSA-9697154	3.999676e-01	0.398	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	3.999676e-01	0.398	0	0
Pervasive developmental disorders	R-HSA-9005895	3.999676e-01	0.398	0	0
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	4.031856e-01	0.394	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.031856e-01	0.394	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.031856e-01	0.394	0	0
Signaling by MAP2K mutants	R-HSA-9652169	4.031856e-01	0.394	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	4.031856e-01	0.394	0	0
NADE modulates death signalling	R-HSA-205025	4.031856e-01	0.394	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	4.031856e-01	0.394	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	4.041655e-01	0.393	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	4.072871e-01	0.390	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.099211e-01	0.387	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	4.122355e-01	0.385	0	0
Neurexins and neuroligins	R-HSA-6794361	4.122355e-01	0.385	0	0
G0 and Early G1	R-HSA-1538133	4.127271e-01	0.384	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	4.130413e-01	0.384	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	4.130413e-01	0.384	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	4.166792e-01	0.380	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	4.218267e-01	0.375	1	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	4.295102e-01	0.367	0	0
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	4.295102e-01	0.367	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	4.295102e-01	0.367	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	4.295102e-01	0.367	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	4.295102e-01	0.367	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	4.295102e-01	0.367	0	0
Ca-dependent events	R-HSA-111996	4.297373e-01	0.367	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	4.317302e-01	0.365	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	4.317302e-01	0.365	0	0
Cardiogenesis	R-HSA-9733709	4.317302e-01	0.365	0	0
Notch-HLH transcription pathway	R-HSA-350054	4.325371e-01	0.364	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.325371e-01	0.364	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	4.325371e-01	0.364	0	0
Translation	R-HSA-72766	4.384143e-01	0.358	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	4.422942e-01	0.354	0	0
Pyruvate metabolism	R-HSA-70268	4.433631e-01	0.353	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.505623e-01	0.346	0	0
Vpu mediated degradation of CD4	R-HSA-180534	4.505623e-01	0.346	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	4.507323e-01	0.346	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	4.523904e-01	0.344	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.523904e-01	0.344	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	4.523904e-01	0.344	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	4.523904e-01	0.344	0	0
Defective F9 activation	R-HSA-9673221	4.523904e-01	0.344	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	4.523904e-01	0.344	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	4.523904e-01	0.344	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.523904e-01	0.344	0	0
Reelin signalling pathway	R-HSA-8866376	4.523904e-01	0.344	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.523904e-01	0.344	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	4.523904e-01	0.344	0	0
Interleukin-36 pathway	R-HSA-9014826	4.523904e-01	0.344	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.523904e-01	0.344	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.523904e-01	0.344	0	0
NrCAM interactions	R-HSA-447038	4.523904e-01	0.344	0	0
Assembly of Viral Components at the Budding Site	R-HSA-168316	4.523904e-01	0.344	0	0
Glucose metabolism	R-HSA-70326	4.527211e-01	0.344	0	0
Syndecan interactions	R-HSA-3000170	4.548269e-01	0.342	0	0
Growth hormone receptor signaling	R-HSA-982772	4.548269e-01	0.342	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	4.572092e-01	0.340	1	0
Signaling by NOTCH3	R-HSA-9012852	4.572140e-01	0.340	0	0
Removal of the Flap Intermediate	R-HSA-69166	4.582626e-01	0.339	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	4.582626e-01	0.339	0	0
Zinc transporters	R-HSA-435354	4.582626e-01	0.339	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	4.620356e-01	0.335	1	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	4.620356e-01	0.335	1	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	4.620356e-01	0.335	1	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	4.679412e-01	0.330	1	0
Organelle biogenesis and maintenance	R-HSA-1852241	4.689627e-01	0.329	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	4.691891e-01	0.329	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	4.691891e-01	0.329	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	4.691891e-01	0.329	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	4.691891e-01	0.329	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	4.691891e-01	0.329	0	0
Signaling by NOTCH2	R-HSA-1980145	4.691891e-01	0.329	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.720356e-01	0.326	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	4.720356e-01	0.326	0	0
PTEN Regulation	R-HSA-6807070	4.729626e-01	0.325	0	0
Developmental Cell Lineages	R-HSA-9734767	4.738518e-01	0.324	0	0
Deadenylation of mRNA	R-HSA-429947	4.767412e-01	0.322	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	4.767412e-01	0.322	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.791303e-01	0.320	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	4.791303e-01	0.320	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.794423e-01	0.319	0	0
Regulated Necrosis	R-HSA-5218859	4.794423e-01	0.319	0	0
PKR-mediated signaling	R-HSA-9833482	4.856391e-01	0.314	0	0
Processive synthesis on the lagging strand	R-HSA-69183	4.861545e-01	0.313	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	4.861545e-01	0.313	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	4.861545e-01	0.313	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	4.875790e-01	0.312	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	4.875790e-01	0.312	0	0
Signalling to ERKs	R-HSA-187687	4.875790e-01	0.312	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	4.875790e-01	0.312	0	0
Signaling by TGFBR3	R-HSA-9839373	4.952836e-01	0.305	0	0
Diseases of DNA repair	R-HSA-9675135	4.952836e-01	0.305	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	4.952836e-01	0.305	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	4.975411e-01	0.303	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	4.975411e-01	0.303	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	4.975411e-01	0.303	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	4.975411e-01	0.303	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	4.975411e-01	0.303	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	4.975411e-01	0.303	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	4.975411e-01	0.303	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	4.975411e-01	0.303	0	0
Signaling by RNF43 mutants	R-HSA-5340588	4.975411e-01	0.303	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	4.975411e-01	0.303	0	0
Loss-of-function mutations in DBT cause MSUD2	R-HSA-9865113	4.975411e-01	0.303	0	0
Loss-of-function mutations in DLD cause MSUD3/DLDD	R-HSA-9907570	4.975411e-01	0.303	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	4.975411e-01	0.303	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	4.975411e-01	0.303	0	0
TRAIL signaling	R-HSA-75158	4.975411e-01	0.303	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	4.975411e-01	0.303	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	4.975411e-01	0.303	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	4.975411e-01	0.303	0	0
Intestinal hexose absorption	R-HSA-8981373	4.975411e-01	0.303	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	4.975411e-01	0.303	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	4.975411e-01	0.303	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	4.975411e-01	0.303	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	4.975411e-01	0.303	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	4.982365e-01	0.303	0	0
Tight junction interactions	R-HSA-420029	4.982365e-01	0.303	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	4.982365e-01	0.303	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	5.013144e-01	0.300	0	0
Calmodulin induced events	R-HSA-111933	5.057034e-01	0.296	0	0
CaM pathway	R-HSA-111997	5.057034e-01	0.296	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	5.057034e-01	0.296	0	0
GPVI-mediated activation cascade	R-HSA-114604	5.057034e-01	0.296	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	5.057034e-01	0.296	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.063117e-01	0.296	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	5.104422e-01	0.292	1	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.112458e-01	0.291	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	5.131322e-01	0.290	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.131322e-01	0.290	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	5.131322e-01	0.290	0	0
Killing mechanisms	R-HSA-9664420	5.131322e-01	0.290	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.131322e-01	0.290	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	5.131322e-01	0.290	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.131322e-01	0.290	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	5.144021e-01	0.289	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	5.192755e-01	0.285	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	5.192755e-01	0.285	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	5.192755e-01	0.285	0	0
Hedgehog 'on' state	R-HSA-5632684	5.195715e-01	0.284	0	0
Ion channel transport	R-HSA-983712	5.215555e-01	0.283	0	0
Degradation of AXIN	R-HSA-4641257	5.235362e-01	0.281	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	5.235362e-01	0.281	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	5.269976e-01	0.278	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	5.326989e-01	0.274	1	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.389717e-01	0.268	0	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	5.389717e-01	0.268	0	0
Signaling by LTK in cancer	R-HSA-9842640	5.389717e-01	0.268	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	5.389717e-01	0.268	0	0
STAT5 Activation	R-HSA-9645135	5.389717e-01	0.268	0	0
Autointegration results in viral DNA circles	R-HSA-177539	5.389717e-01	0.268	0	0
H139Hfs13* PPM1K causes a mild variant of MSUD	R-HSA-9912529	5.389717e-01	0.268	0	0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD	R-HSA-9865125	5.389717e-01	0.268	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.389717e-01	0.268	0	0
Neurofascin interactions	R-HSA-447043	5.389717e-01	0.268	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	5.389717e-01	0.268	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.389717e-01	0.268	0	0
HDL clearance	R-HSA-8964011	5.389717e-01	0.268	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.389717e-01	0.268	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.391570e-01	0.268	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	5.391570e-01	0.268	0	0
Disorders of Developmental Biology	R-HSA-9675151	5.391570e-01	0.268	0	0
Coenzyme A biosynthesis	R-HSA-196783	5.391570e-01	0.268	0	0
Insulin processing	R-HSA-264876	5.398263e-01	0.268	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	5.410543e-01	0.267	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	5.410543e-01	0.267	0	0
Degradation of CDH1	R-HSA-9766229	5.425218e-01	0.266	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	5.549029e-01	0.256	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	5.563397e-01	0.255	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	5.578022e-01	0.254	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	5.582371e-01	0.253	0	0
Stabilization of p53	R-HSA-69541	5.582371e-01	0.253	0	0
RAS processing	R-HSA-9648002	5.582371e-01	0.253	0	0
Signaling by NOTCH4	R-HSA-9013694	5.585123e-01	0.253	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	5.642025e-01	0.249	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	5.642025e-01	0.249	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	5.642025e-01	0.249	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	5.653334e-01	0.248	1	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.710934e-01	0.243	0	0
Generation of second messenger molecules	R-HSA-202433	5.750665e-01	0.240	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	5.750665e-01	0.240	0	0
Diseases of Immune System	R-HSA-5260271	5.750665e-01	0.240	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	5.750665e-01	0.240	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	5.769883e-01	0.239	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	5.769883e-01	0.239	0	0
DAG1 core M1 glycosylations	R-HSA-8932506	5.769883e-01	0.239	0	0
Recycling of eIF2:GDP	R-HSA-72731	5.769883e-01	0.239	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	5.769883e-01	0.239	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	5.769883e-01	0.239	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.769883e-01	0.239	0	0
VLDL clearance	R-HSA-8964046	5.769883e-01	0.239	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	5.769883e-01	0.239	0	0
CHL1 interactions	R-HSA-447041	5.769883e-01	0.239	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	5.769883e-01	0.239	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.793609e-01	0.237	0	0
DARPP-32 events	R-HSA-180024	5.793609e-01	0.237	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.882534e-01	0.230	0	0
PKA activation	R-HSA-163615	5.882534e-01	0.230	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	5.882534e-01	0.230	0	0
PKA activation in glucagon signalling	R-HSA-164378	5.882534e-01	0.230	0	0
Mismatch Repair	R-HSA-5358508	5.882534e-01	0.230	0	0
Polo-like kinase mediated events	R-HSA-156711	5.882534e-01	0.230	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	5.882534e-01	0.230	0	0
Nephron development	R-HSA-9831926	5.882534e-01	0.230	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	5.882534e-01	0.230	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.915268e-01	0.228	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	5.915268e-01	0.228	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	5.915268e-01	0.228	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	5.915268e-01	0.228	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	5.915268e-01	0.228	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	5.920537e-01	0.228	1	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	5.920537e-01	0.228	1	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	5.983051e-01	0.223	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.983051e-01	0.223	0	0
Cellular response to hypoxia	R-HSA-1234174	5.984210e-01	0.223	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	6.076047e-01	0.216	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	6.113034e-01	0.214	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	6.113034e-01	0.214	0	0
Maturation of nucleoprotein	R-HSA-9694631	6.113034e-01	0.214	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	6.113034e-01	0.214	0	0
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	6.118721e-01	0.213	0	0
Regulation by c-FLIP	R-HSA-3371378	6.118721e-01	0.213	0	0
phospho-PLA2 pathway	R-HSA-111995	6.118721e-01	0.213	0	0
Dimerization of procaspase-8	R-HSA-69416	6.118721e-01	0.213	0	0
DAG1 core M2 glycosylations	R-HSA-8932504	6.118721e-01	0.213	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.118721e-01	0.213	0	0
MET receptor recycling	R-HSA-8875656	6.118721e-01	0.213	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.118721e-01	0.213	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.118721e-01	0.213	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.118721e-01	0.213	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	6.118721e-01	0.213	0	0
Adrenoceptors	R-HSA-390696	6.118721e-01	0.213	0	0
FGFR1b ligand binding and activation	R-HSA-190370	6.118721e-01	0.213	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	6.118721e-01	0.213	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.118721e-01	0.213	0	0
Intestinal absorption	R-HSA-8963676	6.118721e-01	0.213	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	6.118721e-01	0.213	0	0
Alpha-defensins	R-HSA-1462054	6.118721e-01	0.213	0	0
Sensory processing of sound	R-HSA-9659379	6.200364e-01	0.208	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.210382e-01	0.207	1	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.210382e-01	0.207	1	0
Hemostasis	R-HSA-109582	6.258801e-01	0.204	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.333539e-01	0.198	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.333539e-01	0.198	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.333539e-01	0.198	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.333539e-01	0.198	0	0
Formation of definitive endoderm	R-HSA-9823730	6.333539e-01	0.198	0	0
TBC/RABGAPs	R-HSA-8854214	6.385702e-01	0.195	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	6.385702e-01	0.195	0	0
Ion homeostasis	R-HSA-5578775	6.436591e-01	0.191	0	0
CASP8 activity is inhibited	R-HSA-5218900	6.438811e-01	0.191	0	0
Calcineurin activates NFAT	R-HSA-2025928	6.438811e-01	0.191	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.438811e-01	0.191	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	6.438811e-01	0.191	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	6.438811e-01	0.191	0	0
Regulation of signaling by NODAL	R-HSA-1433617	6.438811e-01	0.191	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	6.438811e-01	0.191	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	6.438811e-01	0.191	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	6.438811e-01	0.191	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	6.438811e-01	0.191	0	0
Interleukin-1 processing	R-HSA-448706	6.438811e-01	0.191	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.438811e-01	0.191	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	6.438811e-01	0.191	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	6.490870e-01	0.188	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	6.495367e-01	0.187	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.516931e-01	0.186	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	6.516931e-01	0.186	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	6.544130e-01	0.184	0	0
Matriglycan biosynthesis on DAG1	R-HSA-9939291	6.544130e-01	0.184	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	6.544130e-01	0.184	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	6.544130e-01	0.184	0	0
DAG and IP3 signaling	R-HSA-1489509	6.678972e-01	0.175	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	6.678972e-01	0.175	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	6.678972e-01	0.175	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	6.678972e-01	0.175	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	6.678972e-01	0.175	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.683191e-01	0.175	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	6.723080e-01	0.172	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.729032e-01	0.172	0	0
MAPK3 (ERK1) activation	R-HSA-110056	6.732521e-01	0.172	0	0
DNA replication initiation	R-HSA-68952	6.732521e-01	0.172	0	0
Folding of actin by CCT/TriC	R-HSA-390450	6.732521e-01	0.172	0	0
Regulation of the apoptosome activity	R-HSA-9627069	6.732521e-01	0.172	0	0
Regulation of CDH11 function	R-HSA-9762292	6.732521e-01	0.172	0	0
Formation of apoptosome	R-HSA-111458	6.732521e-01	0.172	0	0
Binding and entry of HIV virion	R-HSA-173107	6.732521e-01	0.172	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	6.732521e-01	0.172	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	6.732521e-01	0.172	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	6.732521e-01	0.172	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	6.732521e-01	0.172	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	6.732521e-01	0.172	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	6.732521e-01	0.172	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	6.732521e-01	0.172	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	6.732521e-01	0.172	0	0
Interleukin-27 signaling	R-HSA-9020956	6.732521e-01	0.172	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	6.732521e-01	0.172	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	6.732521e-01	0.172	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	6.744943e-01	0.171	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	6.744943e-01	0.171	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	6.744943e-01	0.171	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	6.819336e-01	0.166	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	6.819336e-01	0.166	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	6.824410e-01	0.166	0	0
Peroxisomal protein import	R-HSA-9033241	6.824410e-01	0.166	0	0
eNOS activation	R-HSA-203615	6.843569e-01	0.165	0	0
RAF activation	R-HSA-5673000	6.843569e-01	0.165	0	0
Rab regulation of trafficking	R-HSA-9007101	6.887204e-01	0.162	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	6.936157e-01	0.159	0	0
LDL clearance	R-HSA-8964038	6.936157e-01	0.159	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	6.936157e-01	0.159	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	7.001504e-01	0.155	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.002022e-01	0.155	0	0
DAG1 core M3 glycosylations	R-HSA-8932505	7.002022e-01	0.155	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.002022e-01	0.155	0	0
LGI-ADAM interactions	R-HSA-5682910	7.002022e-01	0.155	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	7.002022e-01	0.155	0	0
vRNP Assembly	R-HSA-192905	7.002022e-01	0.155	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	7.002022e-01	0.155	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	7.002022e-01	0.155	0	0
Suppression of apoptosis	R-HSA-9635465	7.002022e-01	0.155	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.002022e-01	0.155	0	0
Dissolution of Fibrin Clot	R-HSA-75205	7.002022e-01	0.155	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	7.066634e-01	0.151	0	0
PLC beta mediated events	R-HSA-112043	7.066634e-01	0.151	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.066634e-01	0.151	0	0
Co-stimulation by CD28	R-HSA-389356	7.087413e-01	0.150	0	0
Gluconeogenesis	R-HSA-70263	7.087413e-01	0.150	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.117990e-01	0.148	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.117990e-01	0.148	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.117990e-01	0.148	0	0
SARS-CoV-2 Infection	R-HSA-9694516	7.130128e-01	0.147	0	0
Glycosphingolipid transport	R-HSA-9845576	7.146770e-01	0.146	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	7.146770e-01	0.146	0	0
RNA Polymerase III Transcription	R-HSA-74158	7.146770e-01	0.146	0	0
Iron uptake and transport	R-HSA-917937	7.173357e-01	0.144	0	0
Cardiac conduction	R-HSA-5576891	7.175594e-01	0.144	0	0
Toll-like Receptor Cascades	R-HSA-168898	7.197460e-01	0.143	1	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.249311e-01	0.140	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	7.249311e-01	0.140	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.249311e-01	0.140	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.249311e-01	0.140	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.249311e-01	0.140	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	7.249311e-01	0.140	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.249311e-01	0.140	0	0
Sodium/Calcium exchangers	R-HSA-425561	7.249311e-01	0.140	0	0
Uptake of dietary cobalamins into enterocytes	R-HSA-9758881	7.249311e-01	0.140	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	7.290687e-01	0.137	0	0
PI3K Cascade	R-HSA-109704	7.338635e-01	0.134	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	7.379204e-01	0.132	0	0
IGF1R signaling cascade	R-HSA-2428924	7.405166e-01	0.130	0	0
Ion transport by P-type ATPases	R-HSA-936837	7.405166e-01	0.130	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.426935e-01	0.129	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	7.454519e-01	0.128	0	0
Acyl chain remodelling of PS	R-HSA-1482801	7.454519e-01	0.128	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.454519e-01	0.128	0	0
Long-term potentiation	R-HSA-9620244	7.454519e-01	0.128	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	7.454519e-01	0.128	0	0
Formation of the nephric duct	R-HSA-9830364	7.454519e-01	0.128	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	7.457978e-01	0.127	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	7.457978e-01	0.127	0	0
Downstream TCR signaling	R-HSA-202424	7.462267e-01	0.127	0	0
Maple Syrup Urine Disease	R-HSA-9865114	7.476215e-01	0.126	0	0
Scavenging by Class F Receptors	R-HSA-3000484	7.476215e-01	0.126	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	7.476215e-01	0.126	0	0
Repression of WNT target genes	R-HSA-4641265	7.476215e-01	0.126	0	0
GRB2 events in EGFR signaling	R-HSA-179812	7.476215e-01	0.126	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	7.476215e-01	0.126	0	0
Signaling by LTK	R-HSA-9842663	7.476215e-01	0.126	0	0
Trafficking and processing of endosomal TLR	R-HSA-1679131	7.476215e-01	0.126	0	0
MET activates RAS signaling	R-HSA-8851805	7.476215e-01	0.126	0	0
Estrogen biosynthesis	R-HSA-193144	7.476215e-01	0.126	0	0
Interleukin-15 signaling	R-HSA-8983432	7.476215e-01	0.126	0	0
Interleukin-35 Signalling	R-HSA-8984722	7.476215e-01	0.126	0	0
OAS antiviral response	R-HSA-8983711	7.476215e-01	0.126	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	7.511409e-01	0.124	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	7.558581e-01	0.122	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	7.573190e-01	0.121	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	7.573190e-01	0.121	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	7.609773e-01	0.119	0	0
Myogenesis	R-HSA-525793	7.609773e-01	0.119	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	7.609773e-01	0.119	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.609773e-01	0.119	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	7.609773e-01	0.119	0	0
Neutrophil degranulation	R-HSA-6798695	7.638428e-01	0.117	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	7.667518e-01	0.115	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	7.684320e-01	0.114	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	7.684320e-01	0.114	0	0
Formation of axial mesoderm	R-HSA-9796292	7.684414e-01	0.114	0	0
FGFR1c ligand binding and activation	R-HSA-190373	7.684414e-01	0.114	0	0
Processing of SMDT1	R-HSA-8949664	7.684414e-01	0.114	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	7.684414e-01	0.114	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	7.684414e-01	0.114	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	7.684414e-01	0.114	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	7.684414e-01	0.114	0	0
Maturation of nucleoprotein	R-HSA-9683610	7.684414e-01	0.114	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	7.684738e-01	0.114	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	7.684738e-01	0.114	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	7.684738e-01	0.114	0	0
G-protein mediated events	R-HSA-112040	7.714102e-01	0.113	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	7.756748e-01	0.110	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	7.756748e-01	0.110	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.756748e-01	0.110	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	7.756748e-01	0.110	0	0
Potential therapeutics for SARS	R-HSA-9679191	7.774214e-01	0.109	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	7.778147e-01	0.109	0	0
RSV-host interactions	R-HSA-9833110	7.786783e-01	0.109	0	0
Maturation of spike protein	R-HSA-9694548	7.805524e-01	0.108	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	7.839205e-01	0.106	0	0
Retrograde neurotrophin signalling	R-HSA-177504	7.875449e-01	0.104	0	0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV	R-HSA-9859138	7.875449e-01	0.104	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	7.875449e-01	0.104	0	0
CRMPs in Sema3A signaling	R-HSA-399956	7.875449e-01	0.104	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	7.875449e-01	0.104	0	0
Regulation of KIT signaling	R-HSA-1433559	7.875449e-01	0.104	0	0
Hydrolysis of LPC	R-HSA-1483115	7.875449e-01	0.104	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	7.875449e-01	0.104	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	7.875449e-01	0.104	0	0
HDL assembly	R-HSA-8963896	7.875449e-01	0.104	0	0
Signal regulatory protein family interactions	R-HSA-391160	7.875449e-01	0.104	0	0
Acyl chain remodeling of CL	R-HSA-1482798	7.875449e-01	0.104	0	0
Insulin receptor recycling	R-HSA-77387	7.895754e-01	0.103	0	0
Interleukin-1 family signaling	R-HSA-446652	7.902842e-01	0.102	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	7.921064e-01	0.101	0	0
HIV Transcription Initiation	R-HSA-167161	7.921064e-01	0.101	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	7.921064e-01	0.101	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	7.921064e-01	0.101	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.967981e-01	0.099	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.994143e-01	0.097	0	0
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	8.027105e-01	0.095	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.031490e-01	0.095	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.050734e-01	0.094	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.050734e-01	0.094	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	8.050734e-01	0.094	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.050734e-01	0.094	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	8.050734e-01	0.094	0	0
SARS-CoV Infections	R-HSA-9679506	8.076131e-01	0.093	0	0
IRS-mediated signalling	R-HSA-112399	8.089243e-01	0.092	0	0
Generic Transcription Pathway	R-HSA-212436	8.115822e-01	0.091	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	8.136943e-01	0.090	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	8.151116e-01	0.089	0	0
Interferon Signaling	R-HSA-913531	8.151802e-01	0.089	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	8.165327e-01	0.088	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	8.172121e-01	0.088	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	8.172121e-01	0.088	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	8.189396e-01	0.087	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.211567e-01	0.086	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.211567e-01	0.086	0	0
Activation of SMO	R-HSA-5635838	8.211567e-01	0.086	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	8.211567e-01	0.086	0	0
Virus Assembly and Release	R-HSA-168268	8.211567e-01	0.086	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.268106e-01	0.083	0	0
Extension of Telomeres	R-HSA-180786	8.268977e-01	0.083	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.268977e-01	0.083	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	8.300744e-01	0.081	1	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	8.333511e-01	0.079	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	8.333511e-01	0.079	0	0
Inositol phosphate metabolism	R-HSA-1483249	8.348640e-01	0.078	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.353452e-01	0.078	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	8.359139e-01	0.078	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	8.359139e-01	0.078	0	0
Phase 2 - plateau phase	R-HSA-5576893	8.359139e-01	0.078	0	0
Passive transport by Aquaporins	R-HSA-432047	8.359139e-01	0.078	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	8.359139e-01	0.078	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	8.359139e-01	0.078	0	0
DAG1 glycosylations	R-HSA-8931838	8.378388e-01	0.077	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.378388e-01	0.077	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.451722e-01	0.073	0	0
ER-Phagosome pathway	R-HSA-1236974	8.457819e-01	0.073	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	8.458880e-01	0.073	0	0
G-protein beta:gamma signalling	R-HSA-397795	8.482271e-01	0.071	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.482271e-01	0.071	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	8.482271e-01	0.071	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.494542e-01	0.071	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	8.494542e-01	0.071	0	0
Choline catabolism	R-HSA-6798163	8.494542e-01	0.071	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	8.494542e-01	0.071	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	8.494542e-01	0.071	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	8.512070e-01	0.070	0	0
Acyl chain remodelling of PC	R-HSA-1482788	8.580061e-01	0.067	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	8.580061e-01	0.067	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.580061e-01	0.067	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	8.580061e-01	0.067	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.580061e-01	0.067	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	8.584252e-01	0.066	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	8.618779e-01	0.065	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	8.618779e-01	0.065	0	0
Apoptotic factor-mediated response	R-HSA-111471	8.618779e-01	0.065	0	0
FGFR1 ligand binding and activation	R-HSA-190242	8.618779e-01	0.065	0	0
Platelet sensitization by LDL	R-HSA-432142	8.618779e-01	0.065	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	8.618779e-01	0.065	0	0
Insulin receptor signalling cascade	R-HSA-74751	8.657542e-01	0.063	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	8.661641e-01	0.062	0	0
Leishmania phagocytosis	R-HSA-9664417	8.661641e-01	0.062	0	0
Parasite infection	R-HSA-9664407	8.661641e-01	0.062	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	8.672056e-01	0.062	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	8.672056e-01	0.062	0	0
Signaling by Insulin receptor	R-HSA-74752	8.706092e-01	0.060	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	8.732770e-01	0.059	0	0
Germ layer formation at gastrulation	R-HSA-9754189	8.732770e-01	0.059	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	8.732770e-01	0.059	0	0
Diseases of hemostasis	R-HSA-9671793	8.732770e-01	0.059	0	0
Acyl chain remodelling of PE	R-HSA-1482839	8.758546e-01	0.058	0	0
Transferrin endocytosis and recycling	R-HSA-917977	8.758546e-01	0.058	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.795090e-01	0.056	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	8.817173e-01	0.055	0	0
Collagen formation	R-HSA-1474290	8.817173e-01	0.055	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	8.837359e-01	0.054	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	8.837359e-01	0.054	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	8.837359e-01	0.054	0	0
Co-inhibition by CTLA4	R-HSA-389513	8.837359e-01	0.054	0	0
Signaling by NODAL	R-HSA-1181150	8.837359e-01	0.054	0	0
Acyl chain remodelling of PI	R-HSA-1482922	8.837359e-01	0.054	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.837359e-01	0.054	0	0
Adipogenesis	R-HSA-9843745	8.838876e-01	0.054	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	8.839803e-01	0.054	0	0
Triglyceride catabolism	R-HSA-163560	8.839812e-01	0.054	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	8.839812e-01	0.054	0	0
Kidney development	R-HSA-9830369	8.852782e-01	0.053	0	0
Circadian clock	R-HSA-9909396	8.883073e-01	0.051	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	8.886174e-01	0.051	0	0
Antigen processing-Cross presentation	R-HSA-1236975	8.897301e-01	0.051	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	8.906882e-01	0.050	0	0
Voltage gated Potassium channels	R-HSA-1296072	8.916127e-01	0.050	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	8.933323e-01	0.049	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	8.933323e-01	0.049	0	0
Acyl chain remodelling of PG	R-HSA-1482925	8.933323e-01	0.049	0	0
Signaling by Interleukins	R-HSA-449147	8.950562e-01	0.048	1	0
Amino acids regulate mTORC1	R-HSA-9639288	8.950810e-01	0.048	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.968643e-01	0.047	0	0
Infectious disease	R-HSA-5663205	9.021027e-01	0.045	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.021370e-01	0.045	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	9.021370e-01	0.045	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.034625e-01	0.044	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.054950e-01	0.043	0	0
Formation of the cornified envelope	R-HSA-6809371	9.055886e-01	0.043	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	9.102155e-01	0.041	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	9.102155e-01	0.041	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.102155e-01	0.041	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.102155e-01	0.041	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	9.102155e-01	0.041	0	0
Signaling by KIT in disease	R-HSA-9669938	9.102155e-01	0.041	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.102155e-01	0.041	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.102155e-01	0.041	0	0
FOXO-mediated transcription	R-HSA-9614085	9.103202e-01	0.041	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.103863e-01	0.041	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.144544e-01	0.039	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.170132e-01	0.038	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.176276e-01	0.037	0	0
Interleukin receptor SHC signaling	R-HSA-912526	9.176276e-01	0.037	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.176276e-01	0.037	0	0
Formation of the ureteric bud	R-HSA-9830674	9.176276e-01	0.037	0	0
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.176276e-01	0.037	0	0
Mitochondrial mRNA modification	R-HSA-9937008	9.176276e-01	0.037	0	0
Carnitine shuttle	R-HSA-200425	9.176276e-01	0.037	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.177002e-01	0.037	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.214641e-01	0.036	0	0
PI Metabolism	R-HSA-1483255	9.222276e-01	0.035	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.232317e-01	0.035	0	0
Mitochondrial RNA degradation	R-HSA-9836573	9.244281e-01	0.034	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	9.244281e-01	0.034	0	0
Plasma lipoprotein assembly	R-HSA-8963898	9.244281e-01	0.034	0	0
Triglyceride metabolism	R-HSA-8979227	9.269692e-01	0.033	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.284113e-01	0.032	0	0
Opioid Signalling	R-HSA-111885	9.293747e-01	0.032	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.306676e-01	0.031	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.306676e-01	0.031	0	0
Hyaluronan degradation	R-HSA-2160916	9.306676e-01	0.031	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.306676e-01	0.031	0	0
Laminin interactions	R-HSA-3000157	9.306676e-01	0.031	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.313259e-01	0.031	0	0
Mitochondrial biogenesis	R-HSA-1592230	9.324969e-01	0.030	0	0
Signaling by SCF-KIT	R-HSA-1433557	9.332593e-01	0.030	0	0
Aquaporin-mediated transport	R-HSA-445717	9.354420e-01	0.029	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.363923e-01	0.029	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.363923e-01	0.029	0	0
TRP channels	R-HSA-3295583	9.363923e-01	0.029	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.363923e-01	0.029	0	0
Urea cycle	R-HSA-70635	9.363923e-01	0.029	0	0
Sphingolipid catabolism	R-HSA-9845614	9.363923e-01	0.029	0	0
ABC transporter disorders	R-HSA-5619084	9.371987e-01	0.028	0	0
Neuronal System	R-HSA-112316	9.372357e-01	0.028	0	0
Mitochondrial protein import	R-HSA-1268020	9.393294e-01	0.027	0	0
Heme signaling	R-HSA-9707616	9.393294e-01	0.027	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.393294e-01	0.027	1	1
Adaptive Immune System	R-HSA-1280218	9.412516e-01	0.026	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.416446e-01	0.026	0	0
Cristae formation	R-HSA-8949613	9.416446e-01	0.026	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.416446e-01	0.026	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	9.416446e-01	0.026	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	9.416446e-01	0.026	0	0
Triglyceride biosynthesis	R-HSA-75109	9.416446e-01	0.026	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	9.416446e-01	0.026	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.420375e-01	0.026	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.430528e-01	0.025	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.437048e-01	0.025	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.460037e-01	0.024	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.464635e-01	0.024	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	9.464635e-01	0.024	0	0
Pyroptosis	R-HSA-5620971	9.464635e-01	0.024	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.490429e-01	0.023	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	9.508847e-01	0.022	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.508847e-01	0.022	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	9.508847e-01	0.022	1	0
Glucagon-type ligand receptors	R-HSA-420092	9.508847e-01	0.022	0	0
Platelet calcium homeostasis	R-HSA-418360	9.508847e-01	0.022	0	0
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.508847e-01	0.022	0	0
Extracellular matrix organization	R-HSA-1474244	9.508906e-01	0.022	0	0
GPER1 signaling	R-HSA-9634597	9.531735e-01	0.021	0	0
DAP12 signaling	R-HSA-2424491	9.549411e-01	0.020	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	9.549411e-01	0.020	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	9.549411e-01	0.020	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	9.549411e-01	0.020	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.549411e-01	0.020	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.549411e-01	0.020	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.553194e-01	0.020	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.569399e-01	0.019	0	0
Regulation of insulin secretion	R-HSA-422356	9.569399e-01	0.019	0	0
Protein localization	R-HSA-9609507	9.572550e-01	0.019	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.584453e-01	0.018	0	0
Leishmania infection	R-HSA-9658195	9.584510e-01	0.018	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.584510e-01	0.018	0	0
Trafficking of AMPA receptors	R-HSA-399719	9.586626e-01	0.018	0	0
Cargo concentration in the ER	R-HSA-5694530	9.586626e-01	0.018	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.586626e-01	0.018	0	0
Downstream signal transduction	R-HSA-186763	9.586626e-01	0.018	0	0
Azathioprine ADME	R-HSA-9748787	9.594276e-01	0.018	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.598617e-01	0.018	0	0
Cellular response to chemical stress	R-HSA-9711123	9.598703e-01	0.018	0	0
Signaling by WNT in cancer	R-HSA-4791275	9.620770e-01	0.017	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.622462e-01	0.017	0	0
Complex IV assembly	R-HSA-9864848	9.622462e-01	0.017	0	0
The phototransduction cascade	R-HSA-2514856	9.622462e-01	0.017	0	0
tRNA processing	R-HSA-72306	9.626640e-01	0.017	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	9.652096e-01	0.015	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.652096e-01	0.015	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	9.654035e-01	0.015	1	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.654444e-01	0.015	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.658537e-01	0.015	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.673295e-01	0.014	0	0
Miscellaneous transport and binding events	R-HSA-5223345	9.680835e-01	0.014	0	0
Ca2+ pathway	R-HSA-4086398	9.698968e-01	0.013	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.707202e-01	0.013	0	0
Hyaluronan metabolism	R-HSA-2142845	9.707202e-01	0.013	0	0
Signal amplification	R-HSA-392518	9.707202e-01	0.013	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	9.722634e-01	0.012	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.731393e-01	0.012	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	9.731393e-01	0.012	0	0
PERK regulates gene expression	R-HSA-381042	9.731393e-01	0.012	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.735818e-01	0.012	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.737386e-01	0.012	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.745446e-01	0.011	0	0
RUNX2 regulates bone development	R-HSA-8941326	9.753586e-01	0.011	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.753586e-01	0.011	0	0
Dectin-2 family	R-HSA-5621480	9.755913e-01	0.011	0	0
Integration of energy metabolism	R-HSA-163685	9.768982e-01	0.010	0	0
NCAM1 interactions	R-HSA-419037	9.773946e-01	0.010	0	0
Lysine catabolism	R-HSA-71064	9.773946e-01	0.010	0	0
Collagen chain trimerization	R-HSA-8948216	9.773946e-01	0.010	0	0
Metabolism of folate and pterines	R-HSA-196757	9.773946e-01	0.010	0	0
Integrin cell surface interactions	R-HSA-216083	9.783164e-01	0.010	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.789247e-01	0.009	0	0
Elastic fibre formation	R-HSA-1566948	9.792626e-01	0.009	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.792626e-01	0.009	0	0
tRNA Aminoacylation	R-HSA-379724	9.804215e-01	0.009	0	0
Signaling by ALK	R-HSA-201556	9.809763e-01	0.008	0	0
Potassium Channels	R-HSA-1296071	9.818880e-01	0.008	0	0
Interleukin-2 family signaling	R-HSA-451927	9.825484e-01	0.008	0	0
Tryptophan catabolism	R-HSA-71240	9.825484e-01	0.008	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.825484e-01	0.008	0	0
Signaling by PDGF	R-HSA-186797	9.831120e-01	0.007	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.843190e-01	0.007	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.843838e-01	0.007	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.844617e-01	0.007	0	0
Transmission across Chemical Synapses	R-HSA-112315	9.847800e-01	0.007	0	0
Intra-Golgi traffic	R-HSA-6811438	9.853139e-01	0.006	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.853139e-01	0.006	0	0
Neddylation	R-HSA-8951664	9.857117e-01	0.006	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.861075e-01	0.006	0	0
Disease	R-HSA-1643685	9.864317e-01	0.006	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.874577e-01	0.005	0	0
Defensins	R-HSA-1461973	9.876415e-01	0.005	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.883609e-01	0.005	0	0
DAP12 interactions	R-HSA-2172127	9.886631e-01	0.005	0	0
Amine ligand-binding receptors	R-HSA-375280	9.886631e-01	0.005	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.886631e-01	0.005	0	0
SLC transporter disorders	R-HSA-5619102	9.897776e-01	0.004	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.909705e-01	0.004	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.913801e-01	0.004	0	0
ECM proteoglycans	R-HSA-3000178	9.913801e-01	0.004	0	0
Metabolism of cofactors	R-HSA-8978934	9.913801e-01	0.004	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.920062e-01	0.003	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.921600e-01	0.003	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.926364e-01	0.003	0	0
Interferon gamma signaling	R-HSA-877300	9.935931e-01	0.003	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	9.937872e-01	0.003	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.938184e-01	0.003	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.948076e-01	0.002	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	9.949280e-01	0.002	0	0
Cholesterol biosynthesis	R-HSA-191273	9.949280e-01	0.002	0	0
Interleukin-10 signaling	R-HSA-6783783	9.949280e-01	0.002	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.953002e-01	0.002	0	0
G alpha (z) signalling events	R-HSA-418597	9.956133e-01	0.002	0	0
Paracetamol ADME	R-HSA-9753281	9.956133e-01	0.002	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.957288e-01	0.002	0	0
Synthesis of PA	R-HSA-1483166	9.963091e-01	0.002	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.966145e-01	0.001	0	0
G alpha (s) signalling events	R-HSA-418555	9.969280e-01	0.001	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.969556e-01	0.001	0	0
RAB geranylgeranylation	R-HSA-8873719	9.971516e-01	0.001	0	0
Collagen degradation	R-HSA-1442490	9.973873e-01	0.001	0	0
Platelet homeostasis	R-HSA-418346	9.976092e-01	0.001	0	0
Digestion and absorption	R-HSA-8963743	9.978018e-01	0.001	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.979838e-01	0.001	0	0
Neurotransmitter release cycle	R-HSA-112310	9.981318e-01	0.001	0	0
Metabolism of steroid hormones	R-HSA-196071	9.984441e-01	0.001	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.985729e-01	0.001	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.986304e-01	0.001	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.987457e-01	0.001	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.987995e-01	0.001	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.987995e-01	0.001	0	0
Glycosphingolipid catabolism	R-HSA-9840310	9.987995e-01	0.001	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.989153e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.989311e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.990619e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.992069e-01	0.000	0	0
Post-translational protein modification	R-HSA-597592	9.992810e-01	0.000	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.994486e-01	0.000	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.995486e-01	0.000	0	0
Gastrulation	R-HSA-9758941	9.996625e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.996735e-01	0.000	1	0
Bile acid and bile salt metabolism	R-HSA-194068	9.996917e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.997151e-01	0.000	0	0
Immune System	R-HSA-168256	9.997458e-01	0.000	1	0
PPARA activates gene expression	R-HSA-1989781	9.997787e-01	0.000	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.998079e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.998279e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.998485e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.998619e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.999125e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999241e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999431e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.999431e-01	0.000	0	0
Metabolism of proteins	R-HSA-392499	9.999563e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999604e-01	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	9.999832e-01	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	9.999850e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999855e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999874e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999902e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999923e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999927e-01	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	9.999927e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999959e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999970e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999970e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999972e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.999986e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999991e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999992e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999995e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	9.999996e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999996e-01	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999997e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000	0	0
G alpha (q) signalling events	R-HSA-416476	1.000000e+00	0.000	0	0
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
ERK/MAPK targets	R-HSA-198753	1.000000e+00	0.000	1	1
CREB phosphorylation	R-HSA-199920	1.000000e+00	0.000	1	1