PAK4

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00401 S484 EPSD|PSP WASL TSGIVGALMEVMQKRSKAIHssDEDEDEDDEEDFEDDDEWE
O00401 S485 EPSD|PSP WASL SGIVGALMEVMQKRSKAIHssDEDEDEDDEEDFEDDDEWED
O14579 S99 Sugiyama COPE PELQAVRMFADyLAHEsRRDsIVAELDREMsRSVDVTNTTF
O14713 S10 GPS6|PSP ITGB1BP1 ICAP1 ___________MFRKGKKRHssSsSQSSEISTKSKsVDssL
O15013 S1232 Sugiyama ARHGEF10 KIAA0294 VKFIVLATALHEKDKDKsRDsLAPGPEPQDEDQKDALPSGG
O15085 T1292 Sugiyama ARHGEF11 KIAA0380 GERPEQEDMGLCSLEHLPPRtRNsGIWEsPELDRNLAEDAS
O43379 T46 Sugiyama WDR62 C19orf14 PARRGQssPPPAPPICLRRRtRLstAsEETVQNRVsLEKVL
O43623 S158 SIGNOR|PSP SNAI2 SLUG SLUGH STFSGLAKHKQLHCDAQSRKsFSCKYCDKEYVSLGALKMHI
O43623 S254 SIGNOR|PSP SNAI2 SLUG SLUGH THsDVKKYQCKNCsKTFsRMsLLHKHEESGCCVAH______
O95678 S162 Sugiyama KRT75 K6HF KB18 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
O96013 S104 iPTMNet|EPSD PAK4 KIAA1142 LLLDEFENMSVTRsNsLRRDsPPPPARARQENGMPEEPATT
O96013 S12 Sugiyama PAK4 KIAA1142 _________MFGKRKKRVEIsAPsNFEHRVHTGFDQHEQKF
O96013 S148 iPTMNet|EPSD PAK4 KIAA1142 GPGKAGSRGRFAGHsEAGGGsGDRRRAGPEKRPKSSREGsG
O96013 S15 Sugiyama PAK4 KIAA1142 ______MFGKRKKRVEIsAPsNFEHRVHTGFDQHEQKFTGL
O96013 S167 iPTMNet|EPSD PAK4 KIAA1142 GsGDRRRAGPEKRPKSSREGsGGPQESSRDKRPLsGPDVGt
O96013 S181 iPTMNet|EPSD|Sugiyama PAK4 KIAA1142 KSSREGsGGPQESSRDKRPLsGPDVGtPQPAGLAsGAKLAA
O96013 S195 Sugiyama PAK4 KIAA1142 RDKRPLsGPDVGtPQPAGLAsGAKLAAGRPFNtyPRADTDH
O96013 S243 Sugiyama PAK4 KIAA1142 EPHDVAPNGPSAGGLAIPQSssSSSRPPTRARGAPsPGVLG
O96013 S244 Sugiyama PAK4 KIAA1142 PHDVAPNGPSAGGLAIPQSssSSSRPPTRARGAPsPGVLGP
O96013 S258 iPTMNet|EPSD PAK4 KIAA1142 AIPQSssSSSRPPTRARGAPsPGVLGPHAsEPQLAPPACtP
O96013 S291 iPTMNet|EPSD PAK4 KIAA1142 LAPPACtPAAPAVPGPPGPRsPQREPQRVSHEQFRAALQLV
O96013 S41 Sugiyama PAK4 KIAA1142 VHTGFDQHEQKFTGLPRQWQsLIEESARRPKPLVDPACITS
O96013 S474 GPS6|SIGNOR|EPSD|PSP PAK4 KIAA1142 VKLSDFGFCAQVSKEVPRRKsLVGtPYWMAPELISRLPYGP
O96013 S99 iPTMNet|EPSD PAK4 KIAA1142 DGALTLLLDEFENMSVTRsNsLRRDsPPPPARARQENGMPE
O96013 T187 Sugiyama PAK4 KIAA1142 sGGPQESSRDKRPLsGPDVGtPQPAGLAsGAKLAAGRPFNt
O96013 T207 iPTMNet|EPSD PAK4 KIAA1142 tPQPAGLAsGAKLAAGRPFNtyPRADTDHPSRGAQGEPHDV
O96013 T478 iPTMNet|EPSD PAK4 KIAA1142 DFGFCAQVSKEVPRRKsLVGtPYWMAPELISRLPYGPEVDI
P02538 S176 Sugiyama KRT6A K6A KRT6D IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWT
P03372 S305 EPSD|PSP ESR1 ESR NR3A1 DMRAANLWPsPLMIKRSKKNsLALSLtADQMVSALLDAEPP
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04259 S176 Sugiyama KRT6B K6B KRTL1 IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P04637 S215 EPSD|PSP TP53 P53 IRVEGNLRVEYLDDRNtFRHsVVVPyEPPEVGSDCTTIHYN
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05787 S104 Sugiyama KRT8 CYK8 IQAVRTQEKEQIKTLNNKFAsFIDKVRFLEQQNKMLETKWS
P05787 S330 Sugiyama KRT8 CYK8 MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P07101 S71 PSP TH TYH APAASYTPTPRsPRFIGRRQsLIEDARKEREAAVAAAAAAV
P07954 S46 SIGNOR|PSP FH PGLGGAAVPSFWPPNAARMAsQNSFRIEyDtFGELKVPNDK
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08729 S104 Sugiyama KRT7 SCL LQRVRQEESEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWT
P09972 S45 Sugiyama ALDOC ALDC APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P12035 S211 Sugiyama KRT3 IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWN
P13647 S181 Sugiyama KRT5 IQRVRTEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P16083 S80 Sugiyama NQO2 NMOR2 LSNPEVFNyGVEtHEAyKQRsLAsDITDEQKKVREADLVIF
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17987 S374 Sugiyama TCP1 CCT1 CCTA ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P18084 S759 SIGNOR|EPSD|PSP ITGB5 LAIWKLLVTIHDRREFAKFQsERsRARYEMAsNPLyRKPIs
P18084 S762 SIGNOR|EPSD|PSP ITGB5 WKLLVTIHDRREFAKFQsERsRARYEMAsNPLyRKPIstHt
P22087 S124 Sugiyama FBL FIB1 FLRN DALVTKNLVPGEsVyGEKRVsIsEGDDKIEyRAWNPFRSKL
P24928 S35 Sugiyama POLR2A POLR2 LRTIKRVQFGVLsPDELKRMsVTEGGIKYPETTEGGRPKLG
P27348 S45 Sugiyama YWHAQ CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P27448 S42 Sugiyama MARK3 CTAK1 EMK2 GDGRQEVTSRTSRSGARCRNsIAsCADEQPHIGNyRLLKTI
P28698 S27 SIGNOR|PSP MZF1 MZF ZNF42 ZSCAN6 GSPDRAPPEDEGPVMVKLEDsEEEGEAALWDPGPEAARLRF
P30048 S199 Sugiyama PRDX3 AOP1 SGLALRGLFIIDPNGVIKHLsVNDLPVGRSVEETLRLVKAF
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P30533 S242 Sugiyama LRPAP1 A2MRAP TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31946 S47 Sugiyama YWHAB AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947 S45 Sugiyama SFN HME1 FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35222 S675 SIGNOR|EPSD|PSP CTNNB1 CTNNB OK/SW-cl.35 PRO2286 AAAVLFRMSEDKPQDyKKRLsVELtssLFRTEPMAWNETAD
P35908 S191 Sugiyama KRT2 KRT2A KRT2E IQNVKAQEREQIKTLNNKFAsFIDKVRFLEQQNQVLQTKWE
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48668 S176 Sugiyama KRT6C KRT6E IQRVRAEEREQIKTLNNKFAsFIDKVRFLEQQNKVLDTKWT
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49023 S272 SIGNOR|EPSD PXN QQQtRIsAssAtRELDELMAsLsDFKIQGLEQRADGERCWA
P49736 S229 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 sHGHNVFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLP
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P50395 T425 Sugiyama GDI2 RABGDIB DAttHFEttCDDIKNIYKRMtGsEFDFEEMKRKKNDIYGED
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53667 T508 EPSD|PSP LIMK1 LIMK EKTQPEGLRSLKKPDRKKRYtVVGNPyWMAPEMINGRSYDE
P53671 T505 PSP LIMK2 MEKATTKKRtLRKNDRKKRYtVVGNPYWMAPEMLNGKSYDE
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 S46 Sugiyama YWHAG AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62258 S46 Sugiyama YWHAE SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62826 S135 SIGNOR|EPSD|PSP RAN ARA24 OK/SW-cl.81 IPIVLCGNKVDIKDRKVKAKsIVFHRKKNLQyyDIsAKSNy
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 S45 Sugiyama YWHAZ CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P63146 S142 Sugiyama UBE2B RAD6B UBCH1 ANSQAAQLYQENKREYEKRVsAIVEQsWNDS__________
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01196 T207 PSP RUNX1 AML1 CBFA2 TKPGSLsFSERLSELEQLRRtAMRVsPHHPAPTPNPRAsLN
Q01546 S196 Sugiyama KRT76 KRT2B KRT2P IGQVKAQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWE
Q04917 S46 Sugiyama YWHAH YWHA1 AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q07866 S524 Sugiyama KLC1 KLC KNS2 QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q12789 S1865 Sugiyama GTF3C1 sPPEGQAPPsHsPRGTKRRAsWAsENGEtDAEGTQMtPAKR
Q12789 S1868 Sugiyama GTF3C1 EGQAPPsHsPRGTKRRAsWAsENGEtDAEGTQMtPAKRPAL
Q13501 S28 Sugiyama SQSTM1 ORCA OSIL AYLLGKEDAAREIRRFsFCCsPEPEAEAEAAAGPGPCERLL
Q13769 S314 Sugiyama THOC5 C22orf19 KIAA0983 VDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQLD
Q14432 T311 Sugiyama PDE3A RsssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKR
Q14CN4 S138 Sugiyama KRT72 K6IRS2 KB35 KRT6 KRT6IRS2 IQRVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWN
Q16236 T369 SIGNOR|PSP NFE2L2 NRF2 NTsPSVAsPEHSVESSSYGDtLLGLsDSEVEELDSAPGSVK
Q3SY84 S143 Sugiyama KRT71 K6IRS1 KB34 KRT6IRS1 IQKVRAQEREQIKALNNKFAsFIDKVRFLEQQNQVLETKWE
Q5T1M5 S1162 Sugiyama FKBP15 KIAA0674 EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5XKE5 S155 Sugiyama KRT79 K6L KB38 KRT6L IQRVRTQEREQIKTLNNKFAsFIDKVRFLEQQNKVLETKWA
Q6IBS0 S139 Sugiyama TWF2 PTK9L MSTP011 DELFGTVKDDLSFAGyQKHLssCAAPAPLtsAERELQQIRI
Q7RTS7 S153 Sugiyama KRT74 K6IRS4 KB37 KRT5C KRT6IRS4 IQKVRAQEREQIKVLNDKFAsFIDKVRFLEQQNQVLETKWE
Q7Z5L9 Y17 Sugiyama IRF2BP2 ____MAAAVAVAAASRRQsCyLCDLPRMPWAMIWDFTEPVC
Q7Z794 S177 Sugiyama KRT77 KRT1B IQRIKTQEREQIMVLNNKFAsFIDKVRFLEQQNQVLQTKWE
Q86VP6 S1221 Sugiyama CAND1 KIAA0829 TIP120 TIP120A QISSNPELAAIFESIQKDssstNLEsMDts___________
Q86VP6 S1226 Sugiyama CAND1 KIAA0829 TIP120 TIP120A PELAAIFESIQKDssstNLEsMDts________________
Q86VP6 S1230 Sugiyama CAND1 KIAA0829 TIP120 TIP120A AIFESIQKDssstNLEsMDts____________________
Q86VP6 T1222 Sugiyama CAND1 KIAA0829 TIP120 TIP120A ISSNPELAAIFESIQKDssstNLEsMDts____________
Q86Y46 S145 Sugiyama KRT73 K6IRS3 KB36 KRT6IRS3 IQKVRAQEREQIKVLNNKFAsFIDKVRFLEQQNQVLETKWE
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8TCS8 S768 Sugiyama PNPT1 PNPASE SRKVLQsPAtTVVRTLNDRssIVMGEPIsQSSSNsQ_____
Q92934 S75 EPSD BAD BBC6 BCL2L8 PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92974 S143 GPS6|EPSD ARHGEF2 KIAA0651 LFP40 AIyPsDsFRQsLLGsRRGRssLSLAKsVsttNIAGHFNDEs
Q92974 S896 GPS6|EPSD ARHGEF2 KIAA0651 LFP40 ARRPVDPRRRsLPAGDALyLsFNPPQPSRGTDRLDLPVtTR
Q93045 S50 EPSD|PSP STMN2 SCG10 SCGN10 RNINIYTYDDMEVKQINKRAsGQAFELILKPPsPISEAPRT
Q969S3 S38 Sugiyama ZNF622 ZPR9 MQRAHYKTDWHRYNLRRKVAsMAPVTAEGFQERVRAQRAVA
Q96D15 S117 Sugiyama RCN3 UNQ239/PRO272 VsLAELRAWIAHTQQRHIRDsVsAAWDtyDtDRDGRVGWEE
Q96G46 S236 Sugiyama DUS3L QQLRKREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPR
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q9BY11 S346 SIGNOR PACSIN1 KIAA1379 VALTNAtGAVEstsQAGDRGsVssyDRGQPYATEWsDDESG
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9NSB2 S178 Sugiyama KRT84 KRTHB4 AQRVKKDEKEQIKTLNNKFAsFIDKVRFLEQQNKLLETKWS
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 5.134182e-11 10.290 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.709453e-10 9.243 0 0
Cell Cycle Checkpoints R-HSA-69620 1.268460e-09 8.897 0 0
HSF1-dependent transactivation R-HSA-3371571 1.429972e-08 7.845 0 0
Signal Transduction R-HSA-162582 1.367683e-08 7.864 1 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.321814e-08 7.634 0 0
DNA methylation R-HSA-5334118 5.405648e-08 7.267 0 0
HDACs deacetylate histones R-HSA-3214815 5.102482e-08 7.292 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.480900e-08 7.188 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.121764e-08 7.213 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.246959e-08 7.034 0 0
Meiotic synapsis R-HSA-1221632 1.037983e-07 6.984 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.078021e-07 6.967 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.326509e-07 6.877 0 0
Cellular response to heat stress R-HSA-3371556 1.340667e-07 6.873 0 0
Chromatin modifying enzymes R-HSA-3247509 1.467029e-07 6.834 0 0
Cell Cycle, Mitotic R-HSA-69278 1.545664e-07 6.811 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.195674e-07 6.658 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.774645e-07 6.557 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.775243e-07 6.321 0 0
Nucleosome assembly R-HSA-774815 4.775243e-07 6.321 0 0
Chromatin organization R-HSA-4839726 4.531376e-07 6.344 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.407415e-07 6.267 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.364366e-07 6.133 0 0
Diseases of programmed cell death R-HSA-9645723 7.158145e-07 6.145 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.065762e-06 5.972 0 0
Attenuation phase R-HSA-3371568 1.070501e-06 5.970 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.191136e-06 5.924 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.325734e-06 5.878 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.641803e-06 5.785 0 0
M Phase R-HSA-68886 1.876380e-06 5.727 0 0
Packaging Of Telomere Ends R-HSA-171306 2.473977e-06 5.607 0 0
Meiosis R-HSA-1500620 2.564604e-06 5.591 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.367632e-06 5.626 0 0
HSF1 activation R-HSA-3371511 4.509404e-06 5.346 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.686945e-06 5.329 0 0
G2/M Checkpoints R-HSA-69481 6.980105e-06 5.156 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.133058e-06 5.090 0 0
TCF dependent signaling in response to WNT R-HSA-201681 8.378438e-06 5.077 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 9.625668e-06 5.017 0 0
Mitotic Prophase R-HSA-68875 1.158523e-05 4.936 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.174181e-05 4.930 0 0
Defective pyroptosis R-HSA-9710421 1.249276e-05 4.903 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.359446e-05 4.867 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.392772e-05 4.856 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.460997e-05 4.835 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.599786e-05 4.796 0 0
Regulation of TP53 Activity R-HSA-5633007 1.795415e-05 4.746 0 0
Death Receptor Signaling R-HSA-73887 1.790075e-05 4.747 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.919027e-05 4.717 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.236563e-05 4.650 0 0
Gene expression (Transcription) R-HSA-74160 2.367887e-05 4.626 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.701241e-05 4.568 0 0
Meiotic recombination R-HSA-912446 2.802904e-05 4.552 0 0
NRAGE signals death through JNK R-HSA-193648 2.851258e-05 4.545 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 3.235667e-05 4.490 0 0
Depyrimidination R-HSA-73928 3.235667e-05 4.490 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.506438e-05 4.455 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.523267e-05 4.453 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.416109e-05 4.266 0 0
RNA Polymerase II Transcription R-HSA-73857 5.441652e-05 4.264 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.869912e-05 4.231 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.411607e-05 4.193 0 0
Cleavage of the damaged purine R-HSA-110331 7.719586e-05 4.112 0 0
Depurination R-HSA-73927 9.954275e-05 4.002 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.051917e-04 3.978 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.297363e-04 3.887 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.297363e-04 3.887 0 0
Reproduction R-HSA-1474165 1.363827e-04 3.865 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.432318e-04 3.844 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.370742e-04 3.863 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.424134e-04 3.846 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.847085e-04 3.734 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.847085e-04 3.734 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.765509e-04 3.753 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.846938e-04 3.734 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.931674e-04 3.714 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.931674e-04 3.714 0 0
G alpha (12/13) signalling events R-HSA-416482 2.449813e-04 3.611 0 0
RNA Polymerase I Transcription R-HSA-73864 2.449813e-04 3.611 0 0
DNA Double Strand Break Response R-HSA-5693606 2.466948e-04 3.608 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.511837e-04 3.600 0 0
Signaling by ROBO receptors R-HSA-376176 2.828456e-04 3.548 1 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.686630e-04 3.571 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.871568e-04 3.542 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.144174e-04 3.502 0 0
Generic Transcription Pathway R-HSA-212436 3.675270e-04 3.435 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.844069e-04 3.415 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 4.365392e-04 3.360 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.548841e-04 3.342 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.548841e-04 3.342 0 0
RMTs methylate histone arginines R-HSA-3214858 4.822130e-04 3.317 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.865982e-04 3.313 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.271090e-04 3.278 0 0
Axon guidance R-HSA-422475 5.349724e-04 3.272 1 0
Nervous system development R-HSA-9675108 5.463433e-04 3.263 1 0
Assembly of the pre-replicative complex R-HSA-68867 5.516982e-04 3.258 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.649016e-04 3.248 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.892938e-04 3.230 0 0
Signaling by WNT R-HSA-195721 5.781333e-04 3.238 0 0
Rap1 signalling R-HSA-392517 5.875083e-04 3.231 0 0
Cell junction organization R-HSA-446728 6.057915e-04 3.218 0 0
HATs acetylate histones R-HSA-3214847 6.343222e-04 3.198 0 0
Ub-specific processing proteases R-HSA-5689880 6.654486e-04 3.177 0 0
Chromosome Maintenance R-HSA-73886 6.833471e-04 3.165 0 0
Cellular Senescence R-HSA-2559583 6.956908e-04 3.158 0 0
Apoptotic execution phase R-HSA-75153 7.152868e-04 3.146 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 7.361323e-04 3.133 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.700046e-04 3.114 0 0
Epigenetic regulation of gene expression R-HSA-212165 7.765732e-04 3.110 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 8.950913e-04 3.048 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.261811e-04 3.033 0 0
Homology Directed Repair R-HSA-5693538 9.846661e-04 3.007 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.908790e-04 3.004 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.209284e-03 2.917 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.209284e-03 2.917 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.180247e-03 2.928 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.407461e-03 2.852 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.407461e-03 2.852 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.535199e-03 2.814 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.567429e-03 2.805 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.719338e-03 2.765 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.783796e-03 2.749 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.783796e-03 2.749 0 0
Activation of RAC1 R-HSA-428540 2.027126e-03 2.693 1 1
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.946150e-03 2.711 0 0
Cell-Cell communication R-HSA-1500931 1.978333e-03 2.704 0 0
Gene Silencing by RNA R-HSA-211000 1.873952e-03 2.727 0 0
Amyloid fiber formation R-HSA-977225 2.033502e-03 2.692 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.319778e-03 2.635 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.335368e-03 2.632 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.349584e-03 2.629 0 0
Apoptosis R-HSA-109581 2.447541e-03 2.611 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.596447e-03 2.586 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.986981e-03 2.525 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.242861e-03 2.489 0 0
Mitotic Prometaphase R-HSA-68877 3.654991e-03 2.437 0 0
Programmed Cell Death R-HSA-5357801 3.451409e-03 2.462 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.487133e-03 2.458 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.451631e-03 2.462 0 0
Interleukin-37 signaling R-HSA-9008059 3.636766e-03 2.439 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.705276e-03 2.431 0 0
HDMs demethylate histones R-HSA-3214842 3.741737e-03 2.427 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.827328e-03 2.417 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.006306e-03 2.397 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.318733e-03 2.365 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.318733e-03 2.365 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.318733e-03 2.365 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.410816e-03 2.355 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.454970e-03 2.351 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.710239e-03 2.327 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.710239e-03 2.327 0 0
mRNA 3'-end processing R-HSA-72187 4.985252e-03 2.302 0 0
FLT3 Signaling R-HSA-9607240 4.541596e-03 2.343 0 0
RET signaling R-HSA-8853659 4.975948e-03 2.303 0 0
Adherens junctions interactions R-HSA-418990 5.311774e-03 2.275 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.474214e-03 2.262 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.474214e-03 2.262 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.474214e-03 2.262 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.718499e-03 2.243 0 0
Deubiquitination R-HSA-5688426 5.902408e-03 2.229 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.977062e-03 2.224 0 0
Mitotic Spindle Checkpoint R-HSA-69618 6.093007e-03 2.215 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 6.099408e-03 2.215 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 6.210121e-03 2.207 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.473996e-03 2.189 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 7.573968e-03 2.121 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.731396e-03 2.112 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.237718e-03 2.084 0 0
DARPP-32 events R-HSA-180024 8.428655e-03 2.074 0 0
Telomere Maintenance R-HSA-157579 8.626818e-03 2.064 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 9.344112e-03 2.029 0 0
Formation of definitive endoderm R-HSA-9823730 9.396326e-03 2.027 0 0
Post NMDA receptor activation events R-HSA-438064 9.484713e-03 2.023 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 9.564317e-03 2.019 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.655629e-03 2.015 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.727682e-03 2.012 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.727682e-03 2.012 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.727682e-03 2.012 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.886715e-03 2.005 0 0
Activation of BH3-only proteins R-HSA-114452 1.010802e-02 1.995 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.154245e-02 1.938 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.137249e-02 1.944 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.137249e-02 1.944 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.137249e-02 1.944 0 0
FOXO-mediated transcription R-HSA-9614085 1.046764e-02 1.980 0 0
Signaling by RAS mutants R-HSA-6802949 1.137249e-02 1.944 0 0
Repression of WNT target genes R-HSA-4641265 1.144483e-02 1.941 0 0
Long-term potentiation R-HSA-9620244 1.097897e-02 1.959 0 0
Neurexins and neuroligins R-HSA-6794361 1.136033e-02 1.945 0 0
Cell-cell junction organization R-HSA-421270 1.105867e-02 1.956 0 0
Mitotic Anaphase R-HSA-68882 1.177033e-02 1.929 0 0
Trafficking of AMPA receptors R-HSA-399719 1.203060e-02 1.920 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.220315e-02 1.914 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.251983e-02 1.902 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.297163e-02 1.887 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.350331e-02 1.870 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.417673e-02 1.848 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.430291e-02 1.845 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.447280e-02 1.839 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.447280e-02 1.839 0 0
Formation of axial mesoderm R-HSA-9796292 1.498074e-02 1.824 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.545489e-02 1.811 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.547689e-02 1.810 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.581754e-02 1.801 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.668682e-02 1.778 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.668682e-02 1.778 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.668682e-02 1.778 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.668682e-02 1.778 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.708025e-02 1.768 0 0
ESR-mediated signaling R-HSA-8939211 1.729527e-02 1.762 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.735581e-02 1.761 0 0
Notch-HLH transcription pathway R-HSA-350054 1.735581e-02 1.761 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.862144e-02 1.730 0 0
TNF signaling R-HSA-75893 1.863319e-02 1.730 0 0
Regulation of KIT signaling R-HSA-1433559 1.921063e-02 1.716 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.206168e-02 1.656 0 0
DAG and IP3 signaling R-HSA-1489509 2.221395e-02 1.653 0 0
RAF activation R-HSA-5673000 2.255784e-02 1.647 0 0
Nuclear import of Rev protein R-HSA-180746 2.255784e-02 1.647 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.255784e-02 1.647 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.255784e-02 1.647 0 0
Signaling by VEGF R-HSA-194138 2.342102e-02 1.630 0 0
Base Excision Repair R-HSA-73884 2.374670e-02 1.624 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.418879e-02 1.616 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.418879e-02 1.616 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.418879e-02 1.616 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.433005e-02 1.614 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.452611e-02 1.610 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.463283e-02 1.608 0 0
G2/M Transition R-HSA-69275 2.478487e-02 1.606 0 0
Neurodegenerative Diseases R-HSA-8863678 2.481687e-02 1.605 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.481687e-02 1.605 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.549378e-02 1.594 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.573244e-02 1.590 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.591399e-02 1.586 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.591399e-02 1.586 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.599700e-02 1.585 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.599700e-02 1.585 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.709443e-02 1.567 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.787198e-02 1.555 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.862268e-02 1.543 0 0
Centrosome maturation R-HSA-380287 3.446065e-02 1.463 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.427160e-02 1.465 0 0
Protein ubiquitination R-HSA-8852135 3.446065e-02 1.463 0 0
Regulation of PTEN localization R-HSA-8948747 2.960551e-02 1.529 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.996261e-02 1.523 0 0
Calmodulin induced events R-HSA-111933 2.979601e-02 1.526 0 0
CaM pathway R-HSA-111997 2.979601e-02 1.526 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.960551e-02 1.529 0 0
Signaling by SCF-KIT R-HSA-1433557 3.718384e-02 1.430 0 0
Ion homeostasis R-HSA-5578775 3.760195e-02 1.425 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.760195e-02 1.425 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.894056e-02 1.410 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.937523e-02 1.405 0 0
Nuclear RNA decay R-HSA-9930044 3.949938e-02 1.403 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.949938e-02 1.403 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.949938e-02 1.403 0 0
Type I hemidesmosome assembly R-HSA-446107 3.970138e-02 1.401 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.970138e-02 1.401 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 4.202627e-02 1.376 0 0
DNA Replication R-HSA-69306 4.385595e-02 1.358 0 0
Signaling by Hippo R-HSA-2028269 4.404759e-02 1.356 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.406678e-02 1.356 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.466045e-02 1.350 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.523195e-02 1.345 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.548383e-02 1.342 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.704142e-02 1.328 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 4.748130e-02 1.323 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 4.748130e-02 1.323 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 4.748130e-02 1.323 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 4.748130e-02 1.323 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.808471e-02 1.318 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.817932e-02 1.317 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.869631e-02 1.313 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.890652e-02 1.311 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.905919e-02 1.309 0 0
ALK mutants bind TKIs R-HSA-9700645 5.152384e-02 1.288 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.921008e-02 1.228 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.921008e-02 1.228 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.241272e-02 1.281 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.241272e-02 1.281 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.534137e-02 1.257 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.534137e-02 1.257 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.241272e-02 1.281 0 0
Ephrin signaling R-HSA-3928664 5.241272e-02 1.281 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.152384e-02 1.288 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.241272e-02 1.281 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.631039e-02 1.249 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.179410e-02 1.286 0 0
Kinesins R-HSA-983189 5.534715e-02 1.257 0 0
DNA Repair R-HSA-73894 5.347699e-02 1.272 0 0
Unwinding of DNA R-HSA-176974 5.152384e-02 1.288 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.241272e-02 1.281 0 0
Diseases of DNA repair R-HSA-9675135 5.179410e-02 1.286 0 0
Translation initiation complex formation R-HSA-72649 5.929509e-02 1.227 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.986925e-02 1.223 0 0
Glycolysis R-HSA-70171 6.055448e-02 1.218 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.151001e-02 1.211 0 0
FLT3 signaling in disease R-HSA-9682385 6.449938e-02 1.190 0 0
Regulation of CDH11 function R-HSA-9762292 6.505704e-02 1.187 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.505704e-02 1.187 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.624172e-02 1.179 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.624172e-02 1.179 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.624172e-02 1.179 0 0
mRNA Splicing R-HSA-72172 6.738956e-02 1.171 0 0
Ca-dependent events R-HSA-111996 6.769973e-02 1.169 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.821325e-02 1.166 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.040600e-02 1.152 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.040600e-02 1.152 0 0
TGFBR3 expression R-HSA-9839394 7.040600e-02 1.152 0 0
Interleukin-7 signaling R-HSA-1266695 7.040600e-02 1.152 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 7.091516e-02 1.149 0 0
Signaling by EGFR R-HSA-177929 7.116997e-02 1.148 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 7.185704e-02 1.144 0 0
Co-inhibition by PD-1 R-HSA-389948 7.595657e-02 1.119 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.623771e-02 1.118 0 0
Regulation of TP53 Expression R-HSA-6804754 7.838973e-02 1.106 0 0
Potassium transport channels R-HSA-1296067 7.838973e-02 1.106 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.006648e-02 1.097 0 0
Cellular responses to stress R-HSA-2262752 8.074003e-02 1.093 0 0
HCMV Late Events R-HSA-9610379 8.155960e-02 1.089 0 0
Netrin-1 signaling R-HSA-373752 8.247550e-02 1.084 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.254221e-02 1.083 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.448061e-02 1.073 0 0
Cardiogenesis R-HSA-9733709 8.533564e-02 1.069 0 0
Cellular responses to stimuli R-HSA-8953897 8.639116e-02 1.064 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.087010e-01 0.964 0 0
KIT mutants bind TKIs R-HSA-9669921 1.087010e-01 0.964 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.087010e-01 0.964 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.087010e-01 0.964 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.087010e-01 0.964 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.087010e-01 0.964 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.087010e-01 0.964 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.087010e-01 0.964 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.087010e-01 0.964 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.087010e-01 0.964 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.087010e-01 0.964 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.015318e-01 0.993 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.062150e-01 0.974 0 0
Hedgehog 'off' state R-HSA-5610787 9.674323e-02 1.014 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 9.026385e-02 1.044 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.781895e-02 1.010 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.949692e-02 1.002 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.053479e-01 0.977 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.698200e-02 1.061 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.863317e-02 1.052 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.003041e-01 0.999 0 0
Signaling by ALK in cancer R-HSA-9700206 1.003041e-01 0.999 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.924570e-02 1.003 0 0
Cardiac conduction R-HSA-5576891 9.068066e-02 1.042 0 0
Neuronal System R-HSA-112316 1.076339e-01 0.968 0 0
PLC beta mediated events R-HSA-112043 1.071741e-01 0.970 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 1.077535e-01 0.968 0 0
SARS-CoV-1-host interactions R-HSA-9692914 9.460521e-02 1.024 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.099498e-01 0.959 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.099498e-01 0.959 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.099498e-01 0.959 0 0
SOS-mediated signalling R-HSA-112412 1.099498e-01 0.959 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 1.099498e-01 0.959 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.116459e-01 0.952 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.129439e-01 0.947 0 0
Specification of primordial germ cells R-HSA-9827857 1.129439e-01 0.947 0 0
Separation of Sister Chromatids R-HSA-2467813 1.136255e-01 0.945 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.138345e-01 0.944 0 0
Developmental Biology R-HSA-1266738 1.141662e-01 0.942 1 0
Signaling by NOTCH R-HSA-157118 1.147420e-01 0.940 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.153143e-01 0.938 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.174424e-01 0.930 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.216226e-01 0.915 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.216226e-01 0.915 0 0
Regulation of gap junction activity R-HSA-191650 1.524654e-01 0.817 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.524654e-01 0.817 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.524654e-01 0.817 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.524654e-01 0.817 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 1.350263e-01 0.870 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.618408e-01 0.791 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.349669e-01 0.870 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.349669e-01 0.870 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 1.291157e-01 0.889 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.462704e-01 0.835 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.462704e-01 0.835 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.643362e-01 0.784 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.643362e-01 0.784 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.643362e-01 0.784 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.643362e-01 0.784 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.643362e-01 0.784 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.258214e-01 0.900 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.389731e-01 0.857 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.389731e-01 0.857 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.671551e-01 0.777 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.259743e-01 0.900 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.627963e-01 0.788 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.627963e-01 0.788 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.595482e-01 0.797 0 0
snRNP Assembly R-HSA-191859 1.559518e-01 0.807 0 0
Metabolism of non-coding RNA R-HSA-194441 1.559518e-01 0.807 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.671551e-01 0.777 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.523528e-01 0.817 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.671551e-01 0.777 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.672039e-01 0.777 0 0
Polo-like kinase mediated events R-HSA-156711 1.291157e-01 0.889 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.558676e-01 0.807 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.259743e-01 0.900 0 0
Peptide chain elongation R-HSA-156902 1.573452e-01 0.803 0 0
Dopamine receptors R-HSA-390651 1.524654e-01 0.817 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.350263e-01 0.870 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 1.618408e-01 0.791 0 0
PKA activation R-HSA-163615 1.291157e-01 0.889 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.443221e-01 0.841 0 0
Signaling by Hedgehog R-HSA-5358351 1.348193e-01 0.870 0 0
MTOR signalling R-HSA-165159 1.280600e-01 0.893 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.277253e-01 0.894 0 0
Sensory perception of sour taste R-HSA-9729555 1.524654e-01 0.817 0 0
HDL assembly R-HSA-8963896 1.558676e-01 0.807 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.558676e-01 0.807 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.397669e-01 0.855 0 0
EPH-Ephrin signaling R-HSA-2682334 1.365006e-01 0.865 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.524654e-01 0.817 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.671551e-01 0.777 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 1.349669e-01 0.870 0 0
TRP channels R-HSA-3295583 1.672039e-01 0.777 0 0
Muscle contraction R-HSA-397014 1.303279e-01 0.885 0 0
Membrane Trafficking R-HSA-199991 1.605311e-01 0.794 0 0
Specification of the neural plate border R-HSA-9834899 1.462704e-01 0.835 0 0
PKA activation in glucagon signalling R-HSA-164378 1.291157e-01 0.889 0 0
Protein hydroxylation R-HSA-9629569 1.643362e-01 0.784 0 0
MAPK family signaling cascades R-HSA-5683057 1.300855e-01 0.886 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.349669e-01 0.870 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.627963e-01 0.788 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.524654e-01 0.817 0 0
Metalloprotease DUBs R-HSA-5689901 1.672039e-01 0.777 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.654610e-01 0.781 0 0
G-protein mediated events R-HSA-112040 1.621803e-01 0.790 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.671551e-01 0.777 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.672039e-01 0.777 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.618408e-01 0.791 0 0
Glucose metabolism R-HSA-70326 1.280577e-01 0.893 0 0
Sodium/Proton exchangers R-HSA-425986 1.350263e-01 0.870 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.359409e-01 0.867 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.273638e-01 0.895 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.389386e-01 0.857 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.673595e-01 0.776 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.710906e-01 0.767 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.752828e-01 0.756 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.752828e-01 0.756 0 0
DCC mediated attractive signaling R-HSA-418885 1.778786e-01 0.750 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.778786e-01 0.750 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.778786e-01 0.750 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.778786e-01 0.750 0 0
p75NTR signals via NF-kB R-HSA-193639 1.778786e-01 0.750 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.778786e-01 0.750 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.778786e-01 0.750 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.778786e-01 0.750 0 0
Generation of second messenger molecules R-HSA-202433 1.790669e-01 0.747 0 0
Opioid Signalling R-HSA-111885 1.809675e-01 0.742 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.821204e-01 0.740 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.821204e-01 0.740 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.821204e-01 0.740 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.830802e-01 0.737 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.832351e-01 0.737 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.838728e-01 0.735 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 1.838728e-01 0.735 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.847135e-01 0.734 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 1.876311e-01 0.727 0 0
Regulation of the apoptosome activity R-HSA-9627069 1.900818e-01 0.721 0 0
Formation of apoptosome R-HSA-111458 1.900818e-01 0.721 0 0
Signal attenuation R-HSA-74749 1.900818e-01 0.721 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.900818e-01 0.721 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 1.900818e-01 0.721 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.900818e-01 0.721 0 0
Tandem pore domain potassium channels R-HSA-1296346 1.900818e-01 0.721 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.931718e-01 0.714 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.931718e-01 0.714 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.931718e-01 0.714 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.931718e-01 0.714 0 0
IRS activation R-HSA-74713 1.931718e-01 0.714 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.931718e-01 0.714 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.931718e-01 0.714 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.931718e-01 0.714 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.931718e-01 0.714 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.931718e-01 0.714 0 0
G1/S Transition R-HSA-69206 1.946205e-01 0.711 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.055917e-01 0.687 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.055917e-01 0.687 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.055917e-01 0.687 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.055917e-01 0.687 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.055917e-01 0.687 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.055917e-01 0.687 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.055917e-01 0.687 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.055917e-01 0.687 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.055917e-01 0.687 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 2.919548e-01 0.535 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.919548e-01 0.535 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.919548e-01 0.535 0 0
Intestinal infectious diseases R-HSA-8942233 2.919548e-01 0.535 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.919548e-01 0.535 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 2.919548e-01 0.535 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 2.919548e-01 0.535 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.919548e-01 0.535 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.919548e-01 0.535 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.919548e-01 0.535 0 0
Defective GALK1 causes GALCT2 R-HSA-5609976 2.919548e-01 0.535 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 2.919548e-01 0.535 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.919548e-01 0.535 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.350466e-01 0.629 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.350466e-01 0.629 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.350466e-01 0.629 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.773553e-01 0.557 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.773553e-01 0.557 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.194453e-01 0.659 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 2.008563e-01 0.697 0 0
Differentiation of T cells R-HSA-9945266 2.008563e-01 0.697 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.008563e-01 0.697 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.496417e-01 0.603 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.496417e-01 0.603 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.246542e-01 0.648 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.803997e-01 0.552 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.803997e-01 0.552 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.803997e-01 0.552 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.803997e-01 0.552 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.803997e-01 0.552 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.803997e-01 0.552 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.803997e-01 0.552 0 0
Late endosomal microautophagy R-HSA-9615710 2.190173e-01 0.660 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.136144e-01 0.670 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.654568e-01 0.576 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.076628e-01 0.683 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.076628e-01 0.683 0 0
EGFR downregulation R-HSA-182971 2.561822e-01 0.591 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.872262e-01 0.542 0 0
Voltage gated Potassium channels R-HSA-1296072 2.469185e-01 0.607 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.753705e-01 0.560 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.772875e-01 0.557 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.672111e-01 0.573 0 0
HCMV Early Events R-HSA-9609690 2.191070e-01 0.659 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.641403e-01 0.578 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.076628e-01 0.683 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.469185e-01 0.607 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.816816e-01 0.550 0 0
Activation of the pre-replicative complex R-HSA-68962 2.373773e-01 0.625 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 2.496417e-01 0.603 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.741275e-01 0.562 0 0
MAP2K and MAPK activation R-HSA-5674135 2.076628e-01 0.683 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.151869e-01 0.667 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.151869e-01 0.667 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.350466e-01 0.629 0 0
Formation of lateral plate mesoderm R-HSA-9758920 2.350466e-01 0.629 0 0
DNA strand elongation R-HSA-69190 2.753705e-01 0.560 0 0
Eukaryotic Translation Termination R-HSA-72764 2.455859e-01 0.610 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.169430e-01 0.664 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.872262e-01 0.542 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.407844e-01 0.618 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.908269e-01 0.536 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.908269e-01 0.536 0 0
S Phase R-HSA-69242 2.817461e-01 0.550 0 0
Hedgehog 'on' state R-HSA-5632684 2.054105e-01 0.687 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.674655e-01 0.573 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.872262e-01 0.542 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.977206e-01 0.704 0 0
Disorders of Developmental Biology R-HSA-9675151 2.246542e-01 0.648 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.803997e-01 0.552 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.976201e-01 0.704 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 2.076628e-01 0.683 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.248181e-01 0.648 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.956875e-01 0.708 0 0
Regulated Necrosis R-HSA-5218859 2.639488e-01 0.578 0 0
Pervasive developmental disorders R-HSA-9005895 2.803997e-01 0.552 0 0
Disorders of Nervous System Development R-HSA-9697154 2.803997e-01 0.552 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.803997e-01 0.552 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.377565e-01 0.624 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.169430e-01 0.664 0 0
Metabolism of RNA R-HSA-8953854 2.023608e-01 0.694 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.773553e-01 0.557 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.988868e-01 0.701 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.150466e-01 0.667 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.055917e-01 0.687 0 0
Inhibition of PKR R-HSA-169131 2.055917e-01 0.687 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.919548e-01 0.535 0 0
Negative regulation of FLT3 R-HSA-9706369 2.008563e-01 0.697 0 0
Signaling by LTK R-HSA-9842663 2.803997e-01 0.552 0 0
mTORC1-mediated signalling R-HSA-166208 2.231964e-01 0.651 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.469185e-01 0.607 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.695232e-01 0.569 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.397734e-01 0.620 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.899680e-01 0.538 0 0
Semaphorin interactions R-HSA-373755 2.009306e-01 0.697 0 0
Rab regulation of trafficking R-HSA-9007101 2.568016e-01 0.590 0 0
Interleukin-1 family signaling R-HSA-446652 2.455497e-01 0.610 0 0
Co-stimulation by CD28 R-HSA-389356 2.015006e-01 0.696 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.225931e-01 0.652 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.350466e-01 0.629 0 0
Nef and signal transduction R-HSA-164944 2.773553e-01 0.557 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.976201e-01 0.704 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.535573e-01 0.596 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.568071e-01 0.590 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.908269e-01 0.536 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.919548e-01 0.535 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.028839e-01 0.693 0 0
G1/S-Specific Transcription R-HSA-69205 2.300617e-01 0.638 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.639488e-01 0.578 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.741275e-01 0.562 0 0
Signaling by ALK R-HSA-201556 2.816816e-01 0.550 0 0
Signaling by TGFBR3 R-HSA-9839373 2.857649e-01 0.544 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.079489e-01 0.682 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.741275e-01 0.562 0 0
Signaling by NOTCH1 R-HSA-1980143 2.655609e-01 0.576 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 2.615970e-01 0.582 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 2.615970e-01 0.582 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 2.615970e-01 0.582 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 2.615970e-01 0.582 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 2.615970e-01 0.582 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.689335e-01 0.433 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.689335e-01 0.433 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.689335e-01 0.433 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.689335e-01 0.433 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.689335e-01 0.433 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.689335e-01 0.433 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.689335e-01 0.433 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.689335e-01 0.433 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.689335e-01 0.433 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.689335e-01 0.433 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.689335e-01 0.433 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.689335e-01 0.433 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.689335e-01 0.433 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 3.689335e-01 0.433 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.689335e-01 0.433 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.689335e-01 0.433 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.689335e-01 0.433 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.689335e-01 0.433 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.689335e-01 0.433 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.689335e-01 0.433 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.195091e-01 0.496 0 0
Netrin mediated repulsion signals R-HSA-418886 3.195091e-01 0.496 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 3.195091e-01 0.496 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.195091e-01 0.496 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 4.375472e-01 0.359 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.375472e-01 0.359 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.375472e-01 0.359 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.375472e-01 0.359 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.375472e-01 0.359 0 0
Invadopodia formation R-HSA-8941237 4.375472e-01 0.359 0 0
Classical Kir channels R-HSA-1296053 4.375472e-01 0.359 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.375472e-01 0.359 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 3.610421e-01 0.442 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.610421e-01 0.442 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.610421e-01 0.442 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.610421e-01 0.442 0 0
Lipophagy R-HSA-9613354 4.015911e-01 0.396 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.015911e-01 0.396 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 4.015911e-01 0.396 0 0
CASP8 activity is inhibited R-HSA-5218900 4.015911e-01 0.396 0 0
MPS VI - Maroteaux-Lamy syndrome R-HSA-2206285 4.987042e-01 0.302 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.987042e-01 0.302 0 0
Erythropoietin activates RAS R-HSA-9027284 3.736568e-01 0.428 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.736568e-01 0.428 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.736568e-01 0.428 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.408794e-01 0.356 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.408794e-01 0.356 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.767315e-01 0.424 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.357632e-01 0.474 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.024191e-01 0.395 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.787019e-01 0.320 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.787019e-01 0.320 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.787019e-01 0.320 0 0
Activation of AMPA receptors R-HSA-399710 5.532147e-01 0.257 0 0
Defective F9 activation R-HSA-9673221 5.532147e-01 0.257 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.532147e-01 0.257 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.532147e-01 0.257 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.532147e-01 0.257 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.532147e-01 0.257 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.749184e-01 0.426 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.990267e-01 0.399 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.268865e-01 0.486 0 0
Orc1 removal from chromatin R-HSA-68949 3.870035e-01 0.412 0 0
Deadenylation of mRNA R-HSA-429947 4.530995e-01 0.344 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.149130e-01 0.288 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.149130e-01 0.288 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.149130e-01 0.288 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.933323e-01 0.307 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.280647e-01 0.368 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.312333e-01 0.365 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.183700e-01 0.378 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.969973e-01 0.401 0 0
Striated Muscle Contraction R-HSA-390522 4.874445e-01 0.312 0 0
Regulation of signaling by CBL R-HSA-912631 5.215090e-01 0.283 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.215090e-01 0.283 0 0
Leading Strand Synthesis R-HSA-69109 5.494159e-01 0.260 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.494159e-01 0.260 0 0
Polymerase switching R-HSA-69091 5.494159e-01 0.260 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.494159e-01 0.260 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.494159e-01 0.260 0 0
Viral mRNA Translation R-HSA-192823 4.399912e-01 0.357 0 0
PPARA activates gene expression R-HSA-1989781 4.326372e-01 0.364 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.261437e-01 0.279 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.141704e-01 0.289 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.494313e-01 0.260 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.494313e-01 0.260 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.821540e-01 0.235 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.821540e-01 0.235 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.073184e-01 0.295 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.534594e-01 0.257 0 0
Signaling by Erythropoietin R-HSA-9006335 5.721028e-01 0.243 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.941188e-01 0.226 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 4.531910e-01 0.344 0 0
PKR-mediated signaling R-HSA-9833482 5.581512e-01 0.253 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.022874e-01 0.299 0 0
RNA Polymerase III Transcription R-HSA-74158 3.749184e-01 0.426 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.893698e-01 0.310 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.488068e-01 0.261 0 0
Integrin signaling R-HSA-354192 4.656911e-01 0.332 0 0
Signaling by ERBB2 R-HSA-1227986 5.225876e-01 0.282 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.346686e-01 0.362 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 4.614208e-01 0.336 0 0
G0 and Early G1 R-HSA-1538133 4.436649e-01 0.353 0 0
Frs2-mediated activation R-HSA-170968 3.114691e-01 0.507 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.941188e-01 0.226 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.703427e-01 0.244 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.195091e-01 0.496 0 0
PI3K/AKT activation R-HSA-198203 4.408794e-01 0.356 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.408794e-01 0.356 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.024191e-01 0.395 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.436649e-01 0.353 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.741438e-01 0.241 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.767315e-01 0.424 0 0
cGMP effects R-HSA-418457 3.426227e-01 0.465 0 0
WNT mediated activation of DVL R-HSA-201688 4.015911e-01 0.396 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.749184e-01 0.426 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.494159e-01 0.260 0 0
Mitophagy R-HSA-5205647 5.088732e-01 0.293 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.024191e-01 0.395 0 0
Interleukin-2 signaling R-HSA-9020558 4.787019e-01 0.320 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.149130e-01 0.288 0 0
TCR signaling R-HSA-202403 4.336855e-01 0.363 0 0
Autophagy R-HSA-9612973 3.577535e-01 0.446 0 0
Apoptotic factor-mediated response R-HSA-111471 4.933323e-01 0.307 0 0
Recycling pathway of L1 R-HSA-437239 4.464687e-01 0.350 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.494159e-01 0.260 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.763996e-01 0.322 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.862245e-01 0.232 0 0
Adipogenesis R-HSA-9843745 5.245165e-01 0.280 0 0
Selective autophagy R-HSA-9663891 4.401178e-01 0.356 0 0
Prolonged ERK activation events R-HSA-169893 4.043912e-01 0.393 0 0
Calcineurin activates NFAT R-HSA-2025928 4.015911e-01 0.396 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.408794e-01 0.356 0 0
Formation of the posterior neural plate R-HSA-9832991 4.787019e-01 0.320 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.215090e-01 0.283 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.548871e-01 0.342 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.941188e-01 0.226 0 0
Macroautophagy R-HSA-1632852 4.548052e-01 0.342 0 0
DAP12 signaling R-HSA-2424491 3.990267e-01 0.399 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.146502e-01 0.502 0 0
Cellular response to starvation R-HSA-9711097 4.634600e-01 0.334 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.941188e-01 0.226 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.346686e-01 0.362 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.189326e-01 0.496 0 0
Signaling by WNT in cancer R-HSA-4791275 4.436649e-01 0.353 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.132451e-01 0.504 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.505751e-01 0.259 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.412653e-01 0.467 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.174009e-01 0.498 0 0
HCMV Infection R-HSA-9609646 5.294848e-01 0.276 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.610421e-01 0.442 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.426227e-01 0.465 0 0
Cilium Assembly R-HSA-5617833 2.988595e-01 0.525 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.488068e-01 0.261 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.948261e-01 0.306 0 0
Signaling by NODAL R-HSA-1181150 3.251669e-01 0.488 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.279058e-01 0.369 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.779179e-01 0.321 0 0
Glycogen metabolism R-HSA-8982491 4.554172e-01 0.342 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.251669e-01 0.488 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 2.994965e-01 0.524 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 2.994965e-01 0.524 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.106174e-01 0.387 0 0
Signalling to ERKs R-HSA-187687 3.547279e-01 0.450 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.195091e-01 0.496 0 0
mRNA Editing R-HSA-75072 4.015911e-01 0.396 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 4.043912e-01 0.393 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.874445e-01 0.312 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.261437e-01 0.279 0 0
Gastrulation R-HSA-9758941 5.507388e-01 0.259 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.530995e-01 0.344 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.526724e-01 0.344 0 0
Signaling by TGFB family members R-HSA-9006936 4.839488e-01 0.315 0 0
NGF-stimulated transcription R-HSA-9031628 4.647639e-01 0.333 0 0
Transmission across Chemical Synapses R-HSA-112315 5.520217e-01 0.258 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.805383e-01 0.420 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.689335e-01 0.433 0 0
C6 deamination of adenosine R-HSA-75102 3.689335e-01 0.433 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.689335e-01 0.433 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.375472e-01 0.359 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 4.375472e-01 0.359 0 0
Regulation by c-FLIP R-HSA-3371378 3.610421e-01 0.442 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 3.114691e-01 0.507 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.114691e-01 0.507 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.987042e-01 0.302 0 0
Transmission across Electrical Synapses R-HSA-112307 4.987042e-01 0.302 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 4.987042e-01 0.302 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.987042e-01 0.302 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.987042e-01 0.302 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.408794e-01 0.356 0 0
Platelet calcium homeostasis R-HSA-418360 3.765433e-01 0.424 0 0
Signaling by APC mutants R-HSA-4839744 4.787019e-01 0.320 0 0
Suppression of autophagy R-HSA-9636569 5.532147e-01 0.257 0 0
NF-kB is activated and signals survival R-HSA-209560 5.149130e-01 0.288 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.149130e-01 0.288 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.149130e-01 0.288 0 0
Signaling by AXIN mutants R-HSA-4839735 5.149130e-01 0.288 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.821540e-01 0.235 0 0
Signalling to RAS R-HSA-167044 5.751649e-01 0.240 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.751649e-01 0.240 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.707696e-01 0.244 0 0
HIV Life Cycle R-HSA-162587 5.424671e-01 0.266 0 0
Ca2+ pathway R-HSA-4086398 3.324486e-01 0.478 0 0
Host Interactions of HIV factors R-HSA-162909 4.220712e-01 0.375 0 0
HIV Infection R-HSA-162906 5.574533e-01 0.254 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.316042e-01 0.479 0 0
Signaling by FGFR in disease R-HSA-1226099 4.699699e-01 0.328 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 3.093039e-01 0.510 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.834483e-01 0.416 0 0
UCH proteinases R-HSA-5689603 3.751464e-01 0.426 0 0
Signaling by PTK6 R-HSA-8848021 4.312333e-01 0.365 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.312333e-01 0.365 0 0
Protein methylation R-HSA-8876725 3.736568e-01 0.428 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.900975e-01 0.229 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 3.610421e-01 0.442 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.015911e-01 0.396 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 4.346686e-01 0.362 0 0
tRNA processing in the nucleus R-HSA-6784531 4.151489e-01 0.382 0 0
Signaling by NTRKs R-HSA-166520 3.612635e-01 0.442 0 0
Signaling by ERBB4 R-HSA-1236394 3.465890e-01 0.460 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.015911e-01 0.396 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.015911e-01 0.396 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.987042e-01 0.302 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.095888e-01 0.388 0 0
Potassium Channels R-HSA-1296071 3.516105e-01 0.454 0 0
Processing of SMDT1 R-HSA-8949664 5.821540e-01 0.235 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.765433e-01 0.424 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.015911e-01 0.396 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.494159e-01 0.260 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.821540e-01 0.235 0 0
Formation of the nephric duct R-HSA-9830364 4.779179e-01 0.321 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.656911e-01 0.332 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.215090e-01 0.283 0 0
Ion transport by P-type ATPases R-HSA-936837 5.864731e-01 0.232 0 0
L1CAM interactions R-HSA-373760 3.315707e-01 0.479 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.316042e-01 0.479 0 0
DSCAM interactions R-HSA-376172 3.689335e-01 0.433 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.375472e-01 0.359 0 0
Dimerization of procaspase-8 R-HSA-69416 3.610421e-01 0.442 0 0
Maturation of nucleoprotein R-HSA-9683610 3.114691e-01 0.507 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.015911e-01 0.396 0 0
Synthesis of PI R-HSA-1483226 4.787019e-01 0.320 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.751649e-01 0.240 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 5.704431e-01 0.244 0 0
Aquaporin-mediated transport R-HSA-445717 5.389097e-01 0.268 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.530995e-01 0.344 0 0
PI Metabolism R-HSA-1483255 4.272976e-01 0.369 0 0
Stimuli-sensing channels R-HSA-2672351 4.092102e-01 0.388 0 0
Sensory processing of sound R-HSA-9659379 3.041973e-01 0.517 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.472802e-01 0.349 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.043034e-01 0.297 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.874445e-01 0.312 0 0
Histamine receptors R-HSA-390650 4.375472e-01 0.359 0 0
Maturation of nucleoprotein R-HSA-9694631 2.995192e-01 0.524 0 0
Selenocysteine synthesis R-HSA-2408557 4.146044e-01 0.382 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.326372e-01 0.364 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 3.736568e-01 0.428 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.632031e-01 0.334 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.864354e-01 0.232 0 0
PTEN Regulation R-HSA-6807070 3.443085e-01 0.463 0 0
Formation of the anterior neural plate R-HSA-9823739 3.736568e-01 0.428 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.751649e-01 0.240 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.195091e-01 0.496 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.195091e-01 0.496 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.994965e-01 0.524 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.175390e-01 0.498 0 0
Passive transport by Aquaporins R-HSA-432047 4.346686e-01 0.362 0 0
NrCAM interactions R-HSA-447038 5.532147e-01 0.257 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.541241e-01 0.451 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.149130e-01 0.288 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.610421e-01 0.442 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.787019e-01 0.320 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.504168e-01 0.259 0 0
RUNX2 regulates bone development R-HSA-8941326 5.505751e-01 0.259 0 0
GAB1 signalosome R-HSA-180292 4.933323e-01 0.307 0 0
Interleukin-15 signaling R-HSA-8983432 5.494159e-01 0.260 0 0
Influenza Infection R-HSA-168255 3.477703e-01 0.459 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.114691e-01 0.507 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.874445e-01 0.312 0 0
Pyroptosis R-HSA-5620971 5.494313e-01 0.260 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.149130e-01 0.288 0 0
OAS antiviral response R-HSA-8983711 5.494159e-01 0.260 0 0
Signaling by Leptin R-HSA-2586552 4.408794e-01 0.356 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 4.933323e-01 0.307 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.005371e-01 0.221 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.005371e-01 0.221 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.005371e-01 0.221 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 6.005371e-01 0.221 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.018007e-01 0.221 0 0
PDE3B signalling R-HSA-165160 6.018007e-01 0.221 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.018007e-01 0.221 0 0
PKB-mediated events R-HSA-109703 6.018007e-01 0.221 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.018007e-01 0.221 0 0
Signaling by MAPK mutants R-HSA-9652817 6.018007e-01 0.221 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.018007e-01 0.221 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.018007e-01 0.221 0 0
NGF-independant TRKA activation R-HSA-187024 6.018007e-01 0.221 0 0
Formation of the Editosome R-HSA-75094 6.018007e-01 0.221 0 0
Phosphorylation of Emi1 R-HSA-176417 6.018007e-01 0.221 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.018007e-01 0.221 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.018007e-01 0.221 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.018007e-01 0.221 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.018007e-01 0.221 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.018007e-01 0.221 0 0
Ion channel transport R-HSA-983712 6.042118e-01 0.219 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.096854e-01 0.215 0 0
Stabilization of p53 R-HSA-69541 6.096854e-01 0.215 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.096854e-01 0.215 0 0
MHC class II antigen presentation R-HSA-2132295 6.110061e-01 0.214 0 0
Ribosome-associated quality control R-HSA-9948299 6.111331e-01 0.214 0 0
Removal of the Flap Intermediate R-HSA-69166 6.131031e-01 0.212 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.131031e-01 0.212 0 0
Signal regulatory protein family interactions R-HSA-391160 6.131031e-01 0.212 0 0
P2Y receptors R-HSA-417957 6.131031e-01 0.212 0 0
Downstream signal transduction R-HSA-186763 6.154471e-01 0.211 0 0
GPER1 signaling R-HSA-9634597 6.231392e-01 0.205 0 0
Signaling by KIT in disease R-HSA-9669938 6.248906e-01 0.204 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.248906e-01 0.204 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.248906e-01 0.204 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 6.248906e-01 0.204 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.283560e-01 0.202 0 0
HIV Transcription Elongation R-HSA-167169 6.283560e-01 0.202 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.283560e-01 0.202 0 0
Aggrephagy R-HSA-9646399 6.283560e-01 0.202 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.283560e-01 0.202 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.283560e-01 0.202 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.313194e-01 0.200 0 0
Interleukin-1 signaling R-HSA-9020702 6.360559e-01 0.197 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.398566e-01 0.194 0 0
Degradation of CDH1 R-HSA-9766229 6.398864e-01 0.194 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.417463e-01 0.193 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.422652e-01 0.192 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.422652e-01 0.192 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.422652e-01 0.192 0 0
p38MAPK events R-HSA-171007 6.422652e-01 0.192 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.422652e-01 0.192 0 0
Signaling by Activin R-HSA-1502540 6.422652e-01 0.192 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.422652e-01 0.192 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.422652e-01 0.192 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.451056e-01 0.190 0 0
STAT5 Activation R-HSA-9645135 6.451056e-01 0.190 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.451056e-01 0.190 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 6.451056e-01 0.190 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.451056e-01 0.190 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.451056e-01 0.190 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.451056e-01 0.190 0 0
Abacavir transmembrane transport R-HSA-2161517 6.451056e-01 0.190 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 6.451056e-01 0.190 0 0
CREB phosphorylation R-HSA-199920 6.451056e-01 0.190 0 0
NADPH regeneration R-HSA-389542 6.451056e-01 0.190 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.451056e-01 0.190 0 0
Lipid particle organization R-HSA-8964572 6.451056e-01 0.190 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.461040e-01 0.190 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.461040e-01 0.190 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.464752e-01 0.189 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.482043e-01 0.188 0 0
Carnitine shuttle R-HSA-200425 6.482043e-01 0.188 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.482043e-01 0.188 0 0
Growth hormone receptor signaling R-HSA-982772 6.482043e-01 0.188 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.500221e-01 0.187 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.559466e-01 0.183 0 0
G-protein beta:gamma signalling R-HSA-397795 6.559466e-01 0.183 0 0
Regulation of RAS by GAPs R-HSA-5658442 6.561814e-01 0.183 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.563985e-01 0.183 0 0
Intra-Golgi traffic R-HSA-6811438 6.640280e-01 0.178 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 6.640280e-01 0.178 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.696628e-01 0.174 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.696628e-01 0.174 0 0
Phosphorylation of the APC/C R-HSA-176412 6.696628e-01 0.174 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.696628e-01 0.174 0 0
Activation of SMO R-HSA-5635838 6.696628e-01 0.174 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.696628e-01 0.174 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.696628e-01 0.174 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.696628e-01 0.174 0 0
Regulation of BACH1 activity R-HSA-9708530 6.696628e-01 0.174 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.696628e-01 0.174 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.696628e-01 0.174 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 6.696628e-01 0.174 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.704676e-01 0.174 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.738758e-01 0.171 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.744170e-01 0.171 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.750861e-01 0.171 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.750861e-01 0.171 0 0
Viral Messenger RNA Synthesis R-HSA-168325 6.797527e-01 0.168 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.810031e-01 0.167 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.837033e-01 0.165 0 0
Disinhibition of SNARE formation R-HSA-114516 6.837033e-01 0.165 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.837033e-01 0.165 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.837033e-01 0.165 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.837033e-01 0.165 0 0
mRNA Editing: C to U Conversion R-HSA-72200 6.837033e-01 0.165 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.837033e-01 0.165 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.837033e-01 0.165 0 0
Activation of TRKA receptors R-HSA-187015 6.837033e-01 0.165 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.837033e-01 0.165 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.837033e-01 0.165 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.837033e-01 0.165 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.837033e-01 0.165 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.837033e-01 0.165 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.837033e-01 0.165 0 0
CHL1 interactions R-HSA-447041 6.837033e-01 0.165 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.854408e-01 0.164 0 0
Adaptive Immune System R-HSA-1280218 6.854452e-01 0.164 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.872040e-01 0.163 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.872040e-01 0.163 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.916788e-01 0.160 0 0
Tight junction interactions R-HSA-420029 6.916788e-01 0.160 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 6.929659e-01 0.159 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.934732e-01 0.159 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.934732e-01 0.159 0 0
Heme signaling R-HSA-9707616 6.938388e-01 0.159 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.953348e-01 0.158 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.953348e-01 0.158 0 0
Phase 2 - plateau phase R-HSA-5576893 6.953348e-01 0.158 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.953348e-01 0.158 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.953348e-01 0.158 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 6.953348e-01 0.158 0 0
Coenzyme A biosynthesis R-HSA-196783 6.953348e-01 0.158 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.953348e-01 0.158 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.953348e-01 0.158 0 0
Synthesis of PG R-HSA-1483148 6.953348e-01 0.158 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.973925e-01 0.157 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.002553e-01 0.155 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.002553e-01 0.155 0 0
Smooth Muscle Contraction R-HSA-445355 7.022462e-01 0.154 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.022462e-01 0.154 0 0
Myogenesis R-HSA-525793 7.118439e-01 0.148 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.118439e-01 0.148 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.131915e-01 0.147 0 0
DAP12 interactions R-HSA-2172127 7.131915e-01 0.147 0 0
Interferon Signaling R-HSA-913531 7.180768e-01 0.144 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.181053e-01 0.144 0 0
RSK activation R-HSA-444257 7.181053e-01 0.144 0 0
Formation of annular gap junctions R-HSA-196025 7.181053e-01 0.144 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.181053e-01 0.144 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.181053e-01 0.144 0 0
Adrenoceptors R-HSA-390696 7.181053e-01 0.144 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.181053e-01 0.144 0 0
Alpha-defensins R-HSA-1462054 7.181053e-01 0.144 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.181053e-01 0.144 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.193323e-01 0.143 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.193323e-01 0.143 0 0
Uptake and function of anthrax toxins R-HSA-5210891 7.193323e-01 0.143 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.193323e-01 0.143 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.193323e-01 0.143 0 0
SARS-CoV Infections R-HSA-9679506 7.209180e-01 0.142 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.256002e-01 0.139 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.279839e-01 0.138 0 0
Triglyceride catabolism R-HSA-163560 7.279839e-01 0.138 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.283984e-01 0.138 0 0
Vesicle-mediated transport R-HSA-5653656 7.290499e-01 0.137 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.309759e-01 0.136 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.309759e-01 0.136 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.309759e-01 0.136 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.309759e-01 0.136 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.309759e-01 0.136 0 0
Cristae formation R-HSA-8949613 7.309759e-01 0.136 0 0
Potential therapeutics for SARS R-HSA-9679191 7.342112e-01 0.134 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.417159e-01 0.130 0 0
Mismatch Repair R-HSA-5358508 7.417159e-01 0.130 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.417159e-01 0.130 0 0
Tie2 Signaling R-HSA-210993 7.417159e-01 0.130 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 7.417159e-01 0.130 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.453030e-01 0.128 0 0
Gap junction degradation R-HSA-190873 7.487672e-01 0.126 0 0
Interleukin-1 processing R-HSA-448706 7.487672e-01 0.126 0 0
ARMS-mediated activation R-HSA-170984 7.487672e-01 0.126 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.487672e-01 0.126 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.487672e-01 0.126 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.487672e-01 0.126 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.487672e-01 0.126 0 0
Lysosomal oligosaccharide catabolism R-HSA-8853383 7.487672e-01 0.126 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.487672e-01 0.126 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.487672e-01 0.126 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.487672e-01 0.126 0 0
HIV elongation arrest and recovery R-HSA-167287 7.490931e-01 0.125 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.490931e-01 0.125 0 0
Telomere Extension By Telomerase R-HSA-171319 7.490931e-01 0.125 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.490931e-01 0.125 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.490931e-01 0.125 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.490931e-01 0.125 0 0
Clathrin-mediated endocytosis R-HSA-8856828 7.541435e-01 0.123 0 0
IRS-mediated signalling R-HSA-112399 7.568837e-01 0.121 0 0
Regulation of CDH1 Function R-HSA-9764561 7.568837e-01 0.121 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.570417e-01 0.121 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.570417e-01 0.121 0 0
G alpha (s) signalling events R-HSA-418555 7.602272e-01 0.119 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.625527e-01 0.118 0 0
The NLRP3 inflammasome R-HSA-844456 7.625527e-01 0.118 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.625527e-01 0.118 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.662187e-01 0.116 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.662187e-01 0.116 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.696824e-01 0.114 0 0
Transcription of the HIV genome R-HSA-167172 7.696824e-01 0.114 0 0
Metal ion SLC transporters R-HSA-425410 7.704867e-01 0.113 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.741667e-01 0.111 0 0
2-LTR circle formation R-HSA-164843 7.760957e-01 0.110 0 0
DNA replication initiation R-HSA-68952 7.760957e-01 0.110 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.760957e-01 0.110 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.760957e-01 0.110 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 7.760957e-01 0.110 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.760957e-01 0.110 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.760957e-01 0.110 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.760957e-01 0.110 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.760957e-01 0.110 0 0
Pexophagy R-HSA-9664873 7.760957e-01 0.110 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.760957e-01 0.110 0 0
Maturation of spike protein R-HSA-9683686 7.760957e-01 0.110 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.760957e-01 0.110 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.760957e-01 0.110 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.760957e-01 0.110 0 0
Josephin domain DUBs R-HSA-5689877 7.760957e-01 0.110 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.812878e-01 0.107 0 0
Triglyceride metabolism R-HSA-8979227 7.812878e-01 0.107 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.819143e-01 0.107 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.819143e-01 0.107 0 0
Signal transduction by L1 R-HSA-445144 7.819143e-01 0.107 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.823797e-01 0.107 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.823797e-01 0.107 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.823797e-01 0.107 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.847475e-01 0.105 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.867374e-01 0.104 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.881149e-01 0.103 0 0
Interleukin-2 family signaling R-HSA-451927 7.881149e-01 0.103 0 0
RAB geranylgeranylation R-HSA-8873719 7.927742e-01 0.101 0 0
PI3K Cascade R-HSA-109704 7.956601e-01 0.099 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.976060e-01 0.098 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.976060e-01 0.098 0 0
Budding and maturation of HIV virion R-HSA-162588 7.976060e-01 0.098 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.976060e-01 0.098 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.998750e-01 0.097 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.998750e-01 0.097 0 0
Lagging Strand Synthesis R-HSA-69186 7.998750e-01 0.097 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.998750e-01 0.097 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.998750e-01 0.097 0 0
ChREBP activates metabolic gene expression R-HSA-163765 8.004529e-01 0.097 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.004529e-01 0.097 0 0
Ionotropic activity of kainate receptors R-HSA-451306 8.004529e-01 0.097 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.004529e-01 0.097 0 0
Bicarbonate transporters R-HSA-425381 8.004529e-01 0.097 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.004529e-01 0.097 0 0
LGI-ADAM interactions R-HSA-5682910 8.004529e-01 0.097 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.004529e-01 0.097 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.004529e-01 0.097 0 0
PECAM1 interactions R-HSA-210990 8.004529e-01 0.097 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.004529e-01 0.097 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.013654e-01 0.096 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.020248e-01 0.096 0 0
Circadian clock R-HSA-9909396 8.023515e-01 0.096 0 0
Regulation of insulin secretion R-HSA-422356 8.027347e-01 0.095 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.037920e-01 0.095 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.037920e-01 0.095 0 0
Synthesis of DNA R-HSA-69239 8.040956e-01 0.095 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.074083e-01 0.093 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.119301e-01 0.090 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.122795e-01 0.090 0 0
Translation of Structural Proteins R-HSA-9683701 8.139363e-01 0.089 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.143074e-01 0.089 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.143490e-01 0.089 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.143490e-01 0.089 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 8.165104e-01 0.088 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.165104e-01 0.088 0 0
Attachment and Entry R-HSA-9694614 8.165104e-01 0.088 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.221617e-01 0.085 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 8.221617e-01 0.085 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.221617e-01 0.085 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.221617e-01 0.085 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.221617e-01 0.085 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.221617e-01 0.085 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.221617e-01 0.085 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.221617e-01 0.085 0 0
Sodium/Calcium exchangers R-HSA-425561 8.221617e-01 0.085 0 0
Integration of provirus R-HSA-162592 8.221617e-01 0.085 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.253536e-01 0.083 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.253862e-01 0.083 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.292867e-01 0.081 0 0
FGFR2 alternative splicing R-HSA-6803529 8.318962e-01 0.080 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.318962e-01 0.080 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.318962e-01 0.080 0 0
Insulin receptor signalling cascade R-HSA-74751 8.341164e-01 0.079 0 0
IGF1R signaling cascade R-HSA-2428924 8.341164e-01 0.079 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.371184e-01 0.077 0 0
Signaling by FGFR4 R-HSA-5654743 8.371184e-01 0.077 0 0
Integration of energy metabolism R-HSA-163685 8.374626e-01 0.077 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.380097e-01 0.077 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.415099e-01 0.075 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.415099e-01 0.075 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.415099e-01 0.075 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.415099e-01 0.075 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.415099e-01 0.075 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.415099e-01 0.075 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.415099e-01 0.075 0 0
MET activates RAS signaling R-HSA-8851805 8.415099e-01 0.075 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.415099e-01 0.075 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.415099e-01 0.075 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.415099e-01 0.075 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.415099e-01 0.075 0 0
Estrogen biosynthesis R-HSA-193144 8.415099e-01 0.075 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.415099e-01 0.075 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.433466e-01 0.074 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.453448e-01 0.073 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.461074e-01 0.073 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.461074e-01 0.073 0 0
Syndecan interactions R-HSA-3000170 8.461074e-01 0.073 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.461074e-01 0.073 0 0
G1 Phase R-HSA-69236 8.477722e-01 0.072 0 0
Cyclin D associated events in G1 R-HSA-69231 8.477722e-01 0.072 0 0
Amine ligand-binding receptors R-HSA-375280 8.477722e-01 0.072 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.498369e-01 0.071 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.498369e-01 0.071 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.498369e-01 0.071 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.499786e-01 0.071 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.511561e-01 0.070 0 0
Signaling by Interleukins R-HSA-449147 8.527731e-01 0.069 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.575219e-01 0.067 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.578307e-01 0.067 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.578307e-01 0.067 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.578307e-01 0.067 0 0
Signaling by FGFR3 R-HSA-5654741 8.578307e-01 0.067 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.582678e-01 0.066 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.587541e-01 0.066 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 8.587541e-01 0.066 0 0
Acetylcholine binding and downstream events R-HSA-181431 8.587541e-01 0.066 0 0
Chylomicron remodeling R-HSA-8963901 8.587541e-01 0.066 0 0
Mtb iron assimilation by chelation R-HSA-1222449 8.587541e-01 0.066 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.587541e-01 0.066 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.587541e-01 0.066 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.587541e-01 0.066 0 0
Interleukin-6 signaling R-HSA-1059683 8.587541e-01 0.066 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.590763e-01 0.066 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.592173e-01 0.066 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.592173e-01 0.066 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 8.592173e-01 0.066 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.592173e-01 0.066 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.592173e-01 0.066 0 0
Kidney development R-HSA-9830369 8.605544e-01 0.065 0 0
Regulation of Apoptosis R-HSA-169911 8.609044e-01 0.065 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.609044e-01 0.065 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.609044e-01 0.065 0 0
Oncogene Induced Senescence R-HSA-2559585 8.609044e-01 0.065 0 0
Leishmania phagocytosis R-HSA-9664417 8.619848e-01 0.065 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.619848e-01 0.065 0 0
Parasite infection R-HSA-9664407 8.619848e-01 0.065 0 0
Interferon gamma signaling R-HSA-877300 8.630081e-01 0.064 0 0
PCP/CE pathway R-HSA-4086400 8.638591e-01 0.064 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.673168e-01 0.062 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.687670e-01 0.061 0 0
GPVI-mediated activation cascade R-HSA-114604 8.712489e-01 0.060 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.712974e-01 0.060 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.712974e-01 0.060 0 0
G protein gated Potassium channels R-HSA-1296059 8.712974e-01 0.060 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.712974e-01 0.060 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.712974e-01 0.060 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.712974e-01 0.060 0 0
Prolactin receptor signaling R-HSA-1170546 8.741229e-01 0.058 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.741229e-01 0.058 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.741229e-01 0.058 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.741229e-01 0.058 0 0
The activation of arylsulfatases R-HSA-1663150 8.741229e-01 0.058 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.741229e-01 0.058 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.741229e-01 0.058 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 8.741229e-01 0.058 0 0
Physiological factors R-HSA-5578768 8.741229e-01 0.058 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.741229e-01 0.058 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.741229e-01 0.058 0 0
Malate-aspartate shuttle R-HSA-9856872 8.741229e-01 0.058 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.741229e-01 0.058 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 8.747614e-01 0.058 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.752089e-01 0.058 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.762536e-01 0.057 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.782602e-01 0.056 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.782602e-01 0.056 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.782602e-01 0.056 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.784043e-01 0.056 0 0
Toll-like Receptor Cascades R-HSA-168898 8.799681e-01 0.056 0 0
Degradation of DVL R-HSA-4641258 8.809070e-01 0.055 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.809070e-01 0.055 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.809070e-01 0.055 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.821345e-01 0.054 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.824164e-01 0.054 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.824164e-01 0.054 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.824164e-01 0.054 0 0
Abacavir ADME R-HSA-2161522 8.824164e-01 0.054 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.824164e-01 0.054 0 0
Extension of Telomeres R-HSA-180786 8.830140e-01 0.054 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.834111e-01 0.054 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 8.848437e-01 0.053 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.878203e-01 0.052 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.878203e-01 0.052 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.878203e-01 0.052 0 0
Translesion synthesis by REV1 R-HSA-110312 8.878203e-01 0.052 0 0
Protein lipoylation R-HSA-9857492 8.878203e-01 0.052 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.878203e-01 0.052 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.878203e-01 0.052 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.878203e-01 0.052 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.878203e-01 0.052 0 0
Biotin transport and metabolism R-HSA-196780 8.878203e-01 0.052 0 0
DNA Damage Reversal R-HSA-73942 8.878203e-01 0.052 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.878394e-01 0.052 0 0
Selenoamino acid metabolism R-HSA-2408522 8.880104e-01 0.052 0 0
MET promotes cell motility R-HSA-8875878 8.899144e-01 0.051 0 0
Elastic fibre formation R-HSA-1566948 8.899144e-01 0.051 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.899144e-01 0.051 0 0
GABA receptor activation R-HSA-977443 8.903975e-01 0.050 0 0
Gap junction trafficking and regulation R-HSA-157858 8.925724e-01 0.049 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.926405e-01 0.049 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.926405e-01 0.049 0 0
Triglyceride biosynthesis R-HSA-75109 8.926405e-01 0.049 0 0
Synthesis of PE R-HSA-1483213 8.926405e-01 0.049 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.958232e-01 0.048 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.975556e-01 0.047 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.975556e-01 0.047 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.983066e-01 0.047 0 0
Pentose phosphate pathway R-HSA-71336 8.983066e-01 0.047 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.991074e-01 0.046 0 0
Translesion synthesis by POLI R-HSA-5656121 9.000280e-01 0.046 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.000280e-01 0.046 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.000280e-01 0.046 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.000280e-01 0.046 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 9.000280e-01 0.046 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.000280e-01 0.046 0 0
Killing mechanisms R-HSA-9664420 9.000280e-01 0.046 0 0
Fructose catabolism R-HSA-70350 9.000280e-01 0.046 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.000280e-01 0.046 0 0
Attachment and Entry R-HSA-9678110 9.000280e-01 0.046 0 0
Atorvastatin ADME R-HSA-9754706 9.000280e-01 0.046 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.020326e-01 0.045 0 0
Inflammasomes R-HSA-622312 9.020326e-01 0.045 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.020326e-01 0.045 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.033719e-01 0.044 0 0
Inositol phosphate metabolism R-HSA-1483249 9.036050e-01 0.044 0 0
Signaling by PDGF R-HSA-186797 9.039659e-01 0.044 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.061179e-01 0.043 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.069718e-01 0.042 0 0
The phototransduction cascade R-HSA-2514856 9.069718e-01 0.042 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.084306e-01 0.042 0 0
Signaling by NOTCH4 R-HSA-9013694 9.088918e-01 0.041 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.101838e-01 0.041 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 9.106528e-01 0.041 0 0
mRNA Capping R-HSA-72086 9.106528e-01 0.041 0 0
Termination of translesion DNA synthesis R-HSA-5656169 9.106528e-01 0.041 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.106528e-01 0.041 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.106528e-01 0.041 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.106528e-01 0.041 0 0
Glucagon-type ligand receptors R-HSA-420092 9.106528e-01 0.041 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.106528e-01 0.041 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.109078e-01 0.041 0 0
Translesion synthesis by POLK R-HSA-5655862 9.109078e-01 0.041 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.109078e-01 0.041 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.109078e-01 0.041 0 0
Glycine degradation R-HSA-6783984 9.109078e-01 0.041 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.109078e-01 0.041 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 9.109078e-01 0.041 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 9.109078e-01 0.041 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 9.109078e-01 0.041 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.109078e-01 0.041 0 0
Galactose catabolism R-HSA-70370 9.109078e-01 0.041 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.109078e-01 0.041 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.109078e-01 0.041 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.133818e-01 0.039 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.133818e-01 0.039 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.133818e-01 0.039 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 9.133818e-01 0.039 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.135081e-01 0.039 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.135081e-01 0.039 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.135081e-01 0.039 0 0
Cellular response to chemical stress R-HSA-9711123 9.140052e-01 0.039 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.144543e-01 0.039 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.185577e-01 0.037 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.191569e-01 0.037 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.196317e-01 0.036 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.201305e-01 0.036 0 0
HIV Transcription Initiation R-HSA-167161 9.201305e-01 0.036 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.201305e-01 0.036 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.201305e-01 0.036 0 0
Nucleotide Excision Repair R-HSA-5696398 9.203775e-01 0.036 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.206041e-01 0.036 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 9.206041e-01 0.036 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.206041e-01 0.036 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.206041e-01 0.036 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 9.206041e-01 0.036 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.206041e-01 0.036 0 0
Glycogen storage diseases R-HSA-3229121 9.206041e-01 0.036 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.206041e-01 0.036 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.206041e-01 0.036 0 0
Catecholamine biosynthesis R-HSA-209905 9.206041e-01 0.036 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.206041e-01 0.036 0 0
Choline catabolism R-HSA-6798163 9.206041e-01 0.036 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 9.206041e-01 0.036 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.217036e-01 0.035 0 0
Parasitic Infection Pathways R-HSA-9824443 9.231250e-01 0.035 0 0
Leishmania infection R-HSA-9658195 9.231250e-01 0.035 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.238975e-01 0.034 0 0
Translation of Structural Proteins R-HSA-9694635 9.246979e-01 0.034 0 0
rRNA processing R-HSA-72312 9.248633e-01 0.034 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.258010e-01 0.033 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.258010e-01 0.033 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.258010e-01 0.033 0 0
Neutrophil degranulation R-HSA-6798695 9.283863e-01 0.032 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.292457e-01 0.032 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.292457e-01 0.032 0 0
Nephron development R-HSA-9831926 9.292457e-01 0.032 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.307249e-01 0.031 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.307565e-01 0.031 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.322061e-01 0.030 0 0
TBC/RABGAPs R-HSA-8854214 9.322061e-01 0.030 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.324329e-01 0.030 0 0
Mitochondrial biogenesis R-HSA-1592230 9.332994e-01 0.030 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.338476e-01 0.030 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.357354e-01 0.029 0 0
Signaling by FGFR1 R-HSA-5654736 9.357354e-01 0.029 0 0
Neurotransmitter release cycle R-HSA-112310 9.366950e-01 0.028 0 0
Hemostasis R-HSA-109582 9.368538e-01 0.028 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.369471e-01 0.028 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.369471e-01 0.028 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.369471e-01 0.028 0 0
Pyrimidine biosynthesis R-HSA-500753 9.369471e-01 0.028 0 0
Translesion Synthesis by POLH R-HSA-110320 9.369471e-01 0.028 0 0
Diseases of hemostasis R-HSA-9671793 9.369471e-01 0.028 0 0
Signaling by FGFR2 R-HSA-5654738 9.380419e-01 0.028 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.401786e-01 0.027 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.401786e-01 0.027 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.419978e-01 0.026 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.425787e-01 0.026 0 0
Somitogenesis R-HSA-9824272 9.425787e-01 0.026 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.438107e-01 0.025 0 0
Glycogen synthesis R-HSA-3322077 9.438107e-01 0.025 0 0
Negative regulation of MET activity R-HSA-6807004 9.438107e-01 0.025 0 0
Pregnenolone biosynthesis R-HSA-196108 9.438107e-01 0.025 0 0
Nephrin family interactions R-HSA-373753 9.438107e-01 0.025 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.440487e-01 0.025 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.440487e-01 0.025 0 0
Dual incision in TC-NER R-HSA-6782135 9.447814e-01 0.025 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.463249e-01 0.024 0 0
Viral Infection Pathways R-HSA-9824446 9.463555e-01 0.024 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.471940e-01 0.024 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.471940e-01 0.024 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.471940e-01 0.024 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.471940e-01 0.024 0 0
Protein folding R-HSA-391251 9.475555e-01 0.023 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.488536e-01 0.023 0 0
Dual Incision in GG-NER R-HSA-5696400 9.491179e-01 0.023 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.491179e-01 0.023 0 0
Signal amplification R-HSA-392518 9.491179e-01 0.023 0 0
Hyaluronan metabolism R-HSA-2142845 9.491179e-01 0.023 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.491179e-01 0.023 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.493374e-01 0.023 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.493374e-01 0.023 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.499275e-01 0.022 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.499275e-01 0.022 0 0
Abacavir metabolism R-HSA-2161541 9.499275e-01 0.022 0 0
ERK/MAPK targets R-HSA-198753 9.499275e-01 0.022 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.499275e-01 0.022 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.499275e-01 0.022 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.499275e-01 0.022 0 0
Basigin interactions R-HSA-210991 9.499275e-01 0.022 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.499275e-01 0.022 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.514620e-01 0.022 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.537470e-01 0.021 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.537470e-01 0.021 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.537470e-01 0.021 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.537470e-01 0.021 0 0
PERK regulates gene expression R-HSA-381042 9.537470e-01 0.021 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.553787e-01 0.020 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.553787e-01 0.020 0 0
Ribavirin ADME R-HSA-9755088 9.553787e-01 0.020 0 0
Intraflagellar transport R-HSA-5620924 9.554062e-01 0.020 0 0
Gluconeogenesis R-HSA-70263 9.554062e-01 0.020 0 0
MAP kinase activation R-HSA-450294 9.561827e-01 0.019 0 0
DNA Damage Bypass R-HSA-73893 9.590487e-01 0.018 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.594718e-01 0.018 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.602368e-01 0.018 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.602368e-01 0.018 0 0
LDL clearance R-HSA-8964038 9.602368e-01 0.018 0 0
Fructose metabolism R-HSA-5652084 9.602368e-01 0.018 0 0
Ethanol oxidation R-HSA-71384 9.602368e-01 0.018 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.602368e-01 0.018 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.613298e-01 0.017 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.613298e-01 0.017 0 0
Degradation of AXIN R-HSA-4641257 9.618248e-01 0.017 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.618248e-01 0.017 0 0
NCAM1 interactions R-HSA-419037 9.618248e-01 0.017 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.624105e-01 0.017 0 0
Immune System R-HSA-168256 9.631049e-01 0.016 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.645662e-01 0.016 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.645662e-01 0.016 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.645662e-01 0.016 0 0
Formation of the ureteric bud R-HSA-9830674 9.645662e-01 0.016 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.645662e-01 0.016 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.645662e-01 0.016 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.645662e-01 0.016 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.657833e-01 0.015 0 0
Cellular response to hypoxia R-HSA-1234174 9.680165e-01 0.014 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.680165e-01 0.014 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.683696e-01 0.014 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.683696e-01 0.014 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.684244e-01 0.014 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.684244e-01 0.014 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.684244e-01 0.014 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.684244e-01 0.014 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.684244e-01 0.014 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.684244e-01 0.014 0 0
Interleukin-6 family signaling R-HSA-6783589 9.684244e-01 0.014 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.685382e-01 0.014 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.685382e-01 0.014 0 0
ABC transporter disorders R-HSA-5619084 9.690374e-01 0.014 0 0
Downstream TCR signaling R-HSA-202424 9.707392e-01 0.013 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.714531e-01 0.013 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.714531e-01 0.013 0 0
Diseases of Immune System R-HSA-5260271 9.714531e-01 0.013 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.718628e-01 0.012 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.718628e-01 0.012 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.718628e-01 0.012 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.718628e-01 0.012 0 0
Hyaluronan degradation R-HSA-2160916 9.718628e-01 0.012 0 0
Laminin interactions R-HSA-3000157 9.718628e-01 0.012 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.718628e-01 0.012 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.722154e-01 0.012 0 0
Signaling by MET R-HSA-6806834 9.733412e-01 0.012 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.734278e-01 0.012 0 0
Maturation of spike protein R-HSA-9694548 9.741064e-01 0.011 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.741064e-01 0.011 0 0
IRE1alpha activates chaperones R-HSA-381070 9.746079e-01 0.011 0 0
MET activates PTK2 signaling R-HSA-8874081 9.749269e-01 0.011 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 9.749269e-01 0.011 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.749269e-01 0.011 0 0
Urea cycle R-HSA-70635 9.749269e-01 0.011 0 0
Sphingolipid catabolism R-HSA-9845614 9.749269e-01 0.011 0 0
G alpha (z) signalling events R-HSA-418597 9.756593e-01 0.011 0 0
Signaling by Insulin receptor R-HSA-74752 9.763596e-01 0.010 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.763596e-01 0.010 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.765206e-01 0.010 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 9.776575e-01 0.010 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.776575e-01 0.010 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.776575e-01 0.010 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.776575e-01 0.010 0 0
Signaling by BMP R-HSA-201451 9.776575e-01 0.010 0 0
Insulin processing R-HSA-264876 9.776575e-01 0.010 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.777119e-01 0.010 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.777119e-01 0.010 0 0
Interleukin-17 signaling R-HSA-448424 9.786248e-01 0.009 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.787163e-01 0.009 0 0
Activation of GABAB receptors R-HSA-991365 9.787163e-01 0.009 0 0
GABA B receptor activation R-HSA-977444 9.787163e-01 0.009 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.787163e-01 0.009 0 0
Mitochondrial protein degradation R-HSA-9837999 9.795320e-01 0.009 0 0
Collagen formation R-HSA-1474290 9.795320e-01 0.009 0 0
Synthesis of PA R-HSA-1483166 9.795989e-01 0.009 0 0
Developmental Cell Lineages R-HSA-9734767 9.799990e-01 0.009 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 9.800908e-01 0.009 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.800908e-01 0.009 0 0
Prednisone ADME R-HSA-9757110 9.800908e-01 0.009 0 0
Retinoid metabolism and transport R-HSA-975634 9.803032e-01 0.009 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.806668e-01 0.008 0 0
Interferon alpha/beta signaling R-HSA-909733 9.806668e-01 0.008 0 0
Platelet homeostasis R-HSA-418346 9.819369e-01 0.008 0 0
Thyroxine biosynthesis R-HSA-209968 9.822593e-01 0.008 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.822593e-01 0.008 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.822593e-01 0.008 0 0
Gap junction trafficking R-HSA-190828 9.825263e-01 0.008 0 0
Proteasome assembly R-HSA-9907900 9.825263e-01 0.008 0 0
Peroxisomal protein import R-HSA-9033241 9.829256e-01 0.007 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.829256e-01 0.007 0 0
tRNA processing R-HSA-72306 9.833679e-01 0.007 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.841740e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.841917e-01 0.007 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.841917e-01 0.007 0 0
Mucopolysaccharidoses R-HSA-2206281 9.841917e-01 0.007 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.843876e-01 0.007 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.843876e-01 0.007 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.857293e-01 0.006 0 0
Signaling by FGFR R-HSA-190236 9.858128e-01 0.006 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.858499e-01 0.006 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.858499e-01 0.006 0 0
Cargo concentration in the ER R-HSA-5694530 9.859137e-01 0.006 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.859137e-01 0.006 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.859137e-01 0.006 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 9.859137e-01 0.006 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.860005e-01 0.006 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.860005e-01 0.006 0 0
GPCR downstream signalling R-HSA-388396 9.863639e-01 0.006 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.867068e-01 0.006 0 0
Interleukin-12 signaling R-HSA-9020591 9.869843e-01 0.006 0 0
Synthesis of PC R-HSA-1483191 9.870284e-01 0.006 0 0
HS-GAG degradation R-HSA-2024096 9.874482e-01 0.005 0 0
ABC-family proteins mediated transport R-HSA-382556 9.877770e-01 0.005 0 0
Phospholipid metabolism R-HSA-1483257 9.879291e-01 0.005 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.886878e-01 0.005 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.888157e-01 0.005 0 0
Recycling of bile acids and salts R-HSA-159418 9.888157e-01 0.005 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.888157e-01 0.005 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.888157e-01 0.005 0 0
SLC transporter disorders R-HSA-5619102 9.892272e-01 0.005 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.893787e-01 0.005 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.900342e-01 0.004 0 0
CS/DS degradation R-HSA-2024101 9.900342e-01 0.004 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.902846e-01 0.004 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.909371e-01 0.004 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.911200e-01 0.004 0 0
eNOS activation R-HSA-203615 9.911200e-01 0.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.911200e-01 0.004 0 0
Gap junction assembly R-HSA-190861 9.911200e-01 0.004 0 0
Complex IV assembly R-HSA-9864848 9.913115e-01 0.004 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.913115e-01 0.004 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.914713e-01 0.004 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.917312e-01 0.004 0 0
Nicotinate metabolism R-HSA-196807 9.917312e-01 0.004 0 0
Platelet degranulation R-HSA-114608 9.920574e-01 0.003 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.920876e-01 0.003 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.920876e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.924579e-01 0.003 0 0
Nucleotide biosynthesis R-HSA-8956320 9.928990e-01 0.003 0 0
HS-GAG biosynthesis R-HSA-2022928 9.929498e-01 0.003 0 0
Glycosphingolipid transport R-HSA-9845576 9.929498e-01 0.003 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.929498e-01 0.003 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.929498e-01 0.003 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.937181e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.937181e-01 0.003 0 0
Lysine catabolism R-HSA-71064 9.937181e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.937181e-01 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.937304e-01 0.003 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.942014e-01 0.003 0 0
ECM proteoglycans R-HSA-3000178 9.942861e-01 0.002 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.944027e-01 0.002 0 0
Purine salvage R-HSA-74217 9.944027e-01 0.002 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.947938e-01 0.002 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.950128e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.950128e-01 0.002 0 0
RAS processing R-HSA-9648002 9.950128e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.952687e-01 0.002 0 0
Interleukin-12 family signaling R-HSA-447115 9.953404e-01 0.002 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.953412e-01 0.002 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.955564e-01 0.002 0 0
Formation of the cornified envelope R-HSA-6809371 9.957857e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.960407e-01 0.002 0 0
ER-Phagosome pathway R-HSA-1236974 9.960893e-01 0.002 0 0
Regulation of beta-cell development R-HSA-186712 9.961425e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.965179e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.965179e-01 0.002 0 0
Translation R-HSA-72766 9.968101e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.968573e-01 0.001 0 0
Integrin cell surface interactions R-HSA-216083 9.970366e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.970366e-01 0.001 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.971150e-01 0.001 0 0
RSV-host interactions R-HSA-9833110 9.971626e-01 0.001 0 0
Mitochondrial protein import R-HSA-1268020 9.971641e-01 0.001 0 0
Defensins R-HSA-1461973 9.971995e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.971995e-01 0.001 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.974337e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.974726e-01 0.001 0 0
FCGR activation R-HSA-2029481 9.974876e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.975049e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.975049e-01 0.001 0 0
Signaling by GPCR R-HSA-372790 9.976380e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.976919e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.977769e-01 0.001 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.979771e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.980193e-01 0.001 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.982353e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.982442e-01 0.001 0 0
Mitochondrial translation elongation R-HSA-5389840 9.982442e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.983073e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.983073e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.984278e-01 0.001 0 0
Mitochondrial translation initiation R-HSA-5368286 9.985342e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.985343e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.985992e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.985992e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.987520e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.987603e-01 0.001 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.987840e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.988829e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.988829e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.989647e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.990700e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.990932e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.992644e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.992995e-01 0.000 0 0
Signaling by NOTCH3 R-HSA-9012852 9.992995e-01 0.000 0 0
Digestion R-HSA-8935690 9.993759e-01 0.000 0 0
Neddylation R-HSA-8951664 9.993836e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.994629e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.995122e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.995587e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.995708e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.995872e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996108e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.996498e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.996498e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.996595e-01 0.000 0 0
Protein localization R-HSA-9609507 9.996949e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.997108e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.997221e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.997221e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.997524e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.997794e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.998132e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.998279e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.998321e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.998407e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998441e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.998642e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998763e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999018e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999107e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999117e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999127e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999210e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999221e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.999306e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999510e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999587e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999649e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999733e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999755e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999764e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999810e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999823e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999844e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999914e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999933e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999947e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.999966e-01 0.000 0 0
Disease R-HSA-1643685 9.999967e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999972e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999975e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999978e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999988e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999991e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999994e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999996e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999997e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999997e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999998e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 2.964295e-14 13.528 0 0
Cellular response to heat stress R-HSA-3371556 1.600942e-13 12.796 0 0
Cell Cycle, Mitotic R-HSA-69278 1.935896e-12 11.713 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.343992e-12 11.476 0 0
Attenuation phase R-HSA-3371568 3.008482e-11 10.522 0 0
HSF1-dependent transactivation R-HSA-3371571 3.556844e-11 10.449 0 0
M Phase R-HSA-68886 1.558627e-09 8.807 0 0
HSF1 activation R-HSA-3371511 3.876057e-09 8.412 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.227361e-08 7.911 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.914271e-08 7.718 0 0
Membrane Trafficking R-HSA-199991 1.583723e-07 6.800 0 0
Cell Cycle Checkpoints R-HSA-69620 2.509915e-07 6.600 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.236721e-07 6.490 0 0
Mitotic Prometaphase R-HSA-68877 3.978856e-07 6.400 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.298207e-07 6.367 0 0
Mitotic Anaphase R-HSA-68882 7.697654e-07 6.114 0 0
Apoptotic execution phase R-HSA-75153 7.544036e-07 6.122 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.699831e-07 6.060 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.375082e-06 5.862 0 0
Cellular responses to stress R-HSA-2262752 2.383485e-06 5.623 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.299725e-06 5.482 0 0
Cellular responses to stimuli R-HSA-8953897 3.673472e-06 5.435 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.152997e-06 5.382 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.035076e-06 5.394 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 5.540369e-06 5.256 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.841871e-06 5.106 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.611453e-06 5.017 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.065802e-05 4.972 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.299053e-05 4.886 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.251542e-05 4.903 0 0
Separation of Sister Chromatids R-HSA-2467813 1.216329e-05 4.915 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.238778e-05 4.907 0 0
Apoptosis R-HSA-109581 2.080941e-05 4.682 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.307429e-05 4.481 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.589338e-05 4.445 0 0
G2/M Transition R-HSA-69275 3.895253e-05 4.409 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.142026e-05 4.383 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.360734e-05 4.360 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.360734e-05 4.360 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.204619e-05 4.284 0 0
Centrosome maturation R-HSA-380287 5.154923e-05 4.288 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.830379e-05 4.316 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.204619e-05 4.284 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.154923e-05 4.288 0 0
Nuclear import of Rev protein R-HSA-180746 5.375650e-05 4.270 0 0
Aggrephagy R-HSA-9646399 7.082515e-05 4.150 0 0
Axon guidance R-HSA-422475 7.379806e-05 4.132 1 0
AURKA Activation by TPX2 R-HSA-8854518 7.724324e-05 4.112 0 0
FLT3 Signaling R-HSA-9607240 8.994647e-05 4.046 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.051967e-04 3.978 0 0
G2/M Checkpoints R-HSA-69481 1.033671e-04 3.986 0 0
Signal Transduction R-HSA-162582 1.068826e-04 3.971 1 0
Nervous system development R-HSA-9675108 1.075200e-04 3.969 1 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.157181e-04 3.937 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.226125e-04 3.911 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.226125e-04 3.911 0 0
Regulation of PTEN localization R-HSA-8948747 1.243044e-04 3.906 0 0
Recycling pathway of L1 R-HSA-437239 1.343069e-04 3.872 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.361883e-04 3.866 0 0
Signaling by ALK in cancer R-HSA-9700206 1.361883e-04 3.866 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.419354e-04 3.848 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.656086e-04 3.781 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.620314e-04 3.790 0 0
Signaling by Hippo R-HSA-2028269 1.695959e-04 3.771 0 0
Activation of the pre-replicative complex R-HSA-68962 1.864116e-04 3.730 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.864116e-04 3.730 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.128682e-04 3.672 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.210172e-04 3.656 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.210172e-04 3.656 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.324041e-04 3.634 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 2.324041e-04 3.634 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.416941e-04 3.617 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.416941e-04 3.617 0 0
L1CAM interactions R-HSA-373760 2.498852e-04 3.602 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.587505e-04 3.587 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.828471e-04 3.548 0 0
Chromatin modifying enzymes R-HSA-3247509 3.060606e-04 3.514 0 0
mRNA 3'-end processing R-HSA-72187 3.613288e-04 3.442 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.782864e-04 3.422 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.951709e-04 3.403 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.732913e-04 3.325 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.987975e-04 3.302 0 0
Kinesins R-HSA-983189 5.411946e-04 3.267 0 0
Programmed Cell Death R-HSA-5357801 5.236023e-04 3.281 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.845150e-04 3.233 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.868461e-04 3.231 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.473747e-04 3.189 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.549144e-04 3.122 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.555394e-04 3.122 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.368912e-04 3.133 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.760381e-04 3.110 0 0
G1/S Transition R-HSA-69206 7.899243e-04 3.102 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.195981e-04 3.086 0 0
Mitotic Prophase R-HSA-68875 8.469808e-04 3.072 0 0
Vesicle-mediated transport R-HSA-5653656 9.084368e-04 3.042 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 9.090059e-04 3.041 0 0
FLT3 signaling in disease R-HSA-9682385 9.572639e-04 3.019 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.051345e-03 2.978 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.008845e-03 2.996 0 0
Chromatin organization R-HSA-4839726 9.978758e-04 3.001 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.061443e-03 2.974 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.199556e-03 2.921 0 0
NF-kB is activated and signals survival R-HSA-209560 1.345193e-03 2.871 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.350134e-03 2.870 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.351876e-03 2.869 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.350134e-03 2.870 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.383741e-03 2.859 0 0
Cilium Assembly R-HSA-5617833 1.476949e-03 2.831 0 0
MAP kinase activation R-HSA-450294 1.616396e-03 2.791 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.616396e-03 2.791 0 0
Negative regulation of FLT3 R-HSA-9706369 1.648934e-03 2.783 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.725441e-03 2.763 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.929903e-03 2.714 0 0
Signaling by EGFR R-HSA-177929 1.889501e-03 2.724 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.081491e-03 2.682 0 0
Unwinding of DNA R-HSA-176974 2.081491e-03 2.682 0 0
Post NMDA receptor activation events R-HSA-438064 2.085757e-03 2.681 0 0
Activation of BH3-only proteins R-HSA-114452 2.100547e-03 2.678 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.299763e-03 2.638 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.331959e-03 2.632 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.313890e-03 2.636 0 0
Selective autophagy R-HSA-9663891 2.350444e-03 2.629 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.477995e-03 2.606 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.553207e-03 2.593 0 0
Host Interactions of HIV factors R-HSA-162909 2.559579e-03 2.592 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.694406e-03 2.570 0 0
CREB phosphorylation R-HSA-199920 3.104146e-03 2.508 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.078249e-03 2.512 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.043989e-03 2.517 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.137831e-03 2.503 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.547786e-03 2.450 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.672231e-03 2.435 0 0
MTOR signalling R-HSA-165159 3.480468e-03 2.458 0 0
Regulation of KIT signaling R-HSA-1433559 3.672231e-03 2.435 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.672231e-03 2.435 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.817273e-03 2.418 0 0
Signaling by ERBB4 R-HSA-1236394 4.014814e-03 2.396 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.394006e-03 2.357 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 4.436708e-03 2.353 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.660354e-03 2.332 0 0
S Phase R-HSA-69242 4.726647e-03 2.325 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.753131e-03 2.323 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.898663e-03 2.310 0 0
p75NTR signals via NF-kB R-HSA-193639 4.898663e-03 2.310 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.898663e-03 2.310 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.911229e-03 2.309 0 0
Interleukin-17 signaling R-HSA-448424 5.427245e-03 2.265 0 0
Formation of definitive endoderm R-HSA-9823730 6.213302e-03 2.207 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.754555e-03 2.240 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.754555e-03 2.240 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.220844e-03 2.206 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.578199e-03 2.254 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.260541e-03 2.203 0 0
Orc1 removal from chromatin R-HSA-68949 6.282575e-03 2.202 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.360606e-03 2.197 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.418114e-03 2.193 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.029137e-03 2.153 0 0
HDMs demethylate histones R-HSA-3214842 7.048128e-03 2.152 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 7.228136e-03 2.141 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 7.501615e-03 2.125 0 0
Death Receptor Signaling R-HSA-73887 7.565758e-03 2.121 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.671839e-03 2.115 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.738630e-03 2.111 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.761769e-03 2.110 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.761769e-03 2.110 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.761769e-03 2.110 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.203373e-03 2.086 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.203373e-03 2.086 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.203373e-03 2.086 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.203373e-03 2.086 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.266495e-03 2.083 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.583541e-03 2.018 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.995456e-03 2.046 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.924397e-03 2.049 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.553183e-03 2.068 0 0
G2/M DNA damage checkpoint R-HSA-69473 8.630392e-03 2.064 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.222787e-03 2.035 0 0
Cell-Cell communication R-HSA-1500931 9.594039e-03 2.018 0 0
tRNA processing in the nucleus R-HSA-6784531 9.940546e-03 2.003 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.009716e-02 1.996 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.009716e-02 1.996 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.043715e-02 1.981 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.054508e-02 1.977 0 0
Integrin signaling R-HSA-354192 1.054508e-02 1.977 0 0
Signaling by NOTCH1 R-HSA-1980143 1.072098e-02 1.970 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.080689e-02 1.966 0 0
Synthesis of DNA R-HSA-69239 1.104459e-02 1.957 0 0
Maturation of protein E R-HSA-9683683 1.134937e-02 1.945 0 0
Maturation of protein E R-HSA-9694493 1.134937e-02 1.945 0 0
Regulation of TP53 Activity R-HSA-5633007 1.169036e-02 1.932 0 0
mTORC1-mediated signalling R-HSA-166208 1.170560e-02 1.932 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.205327e-02 1.919 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.238002e-02 1.907 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.293101e-02 1.888 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.302637e-02 1.885 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.302637e-02 1.885 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.302637e-02 1.885 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.415467e-02 1.849 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.400669e-02 1.854 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.593032e-02 1.798 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.401253e-02 1.853 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.394683e-02 1.856 0 0
Signaling by NOTCH2 R-HSA-1980145 1.444557e-02 1.840 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.460477e-02 1.836 0 0
Josephin domain DUBs R-HSA-5689877 1.382822e-02 1.859 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.593912e-02 1.798 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.593912e-02 1.798 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.593912e-02 1.798 0 0
Autophagy R-HSA-9612973 1.484785e-02 1.828 0 0
Macroautophagy R-HSA-1632852 1.373135e-02 1.862 0 0
Pexophagy R-HSA-9664873 1.382822e-02 1.859 0 0
Regulation of signaling by CBL R-HSA-912631 1.604713e-02 1.795 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.604713e-02 1.795 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.612106e-02 1.793 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.643872e-02 1.784 0 0
Inositol phosphate metabolism R-HSA-1483249 1.678076e-02 1.775 0 0
Signaling by ERBB2 R-HSA-1227986 1.692305e-02 1.772 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.692305e-02 1.772 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.692305e-02 1.772 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.692305e-02 1.772 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.692305e-02 1.772 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.692305e-02 1.772 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.692305e-02 1.772 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.722457e-02 1.764 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.767240e-02 1.753 0 0
Translesion synthesis by REV1 R-HSA-110312 1.767240e-02 1.753 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.767240e-02 1.753 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.767240e-02 1.753 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.842687e-02 1.735 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.855484e-02 1.732 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.888365e-02 1.724 0 0
Hedgehog 'off' state R-HSA-5610787 1.889317e-02 1.724 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.933326e-02 1.714 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.953326e-02 1.709 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.984872e-02 1.702 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.349746e-02 1.629 0 0
Regulation of BACH1 activity R-HSA-9708530 2.202873e-02 1.657 0 0
Translesion synthesis by POLI R-HSA-5656121 2.202873e-02 1.657 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.211621e-02 1.655 0 0
Signaling by NOTCH3 R-HSA-9012852 2.047644e-02 1.689 0 0
DNA strand elongation R-HSA-69190 2.317018e-02 1.635 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.202873e-02 1.657 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.963867e-02 1.707 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.096878e-02 1.678 0 0
PTEN Regulation R-HSA-6807070 2.017267e-02 1.695 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.351645e-02 1.629 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.372046e-02 1.625 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.372046e-02 1.625 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.372046e-02 1.625 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.384427e-02 1.623 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.384427e-02 1.623 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.384427e-02 1.623 0 0
Activation of RAC1 R-HSA-428540 2.384427e-02 1.623 1 1
MHC class II antigen presentation R-HSA-2132295 2.565015e-02 1.591 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.672236e-02 1.573 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.672236e-02 1.573 0 0
Translesion synthesis by POLK R-HSA-5655862 2.705605e-02 1.568 0 0
Regulation of gap junction activity R-HSA-191650 2.739871e-02 1.562 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.772835e-02 1.557 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 2.772835e-02 1.557 0 0
Type I hemidesmosome assembly R-HSA-446107 3.169773e-02 1.499 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.218190e-02 1.492 0 0
Dual Incision in GG-NER R-HSA-5696400 3.494538e-02 1.457 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.843036e-02 1.546 0 0
mRNA Splicing R-HSA-72172 2.973467e-02 1.527 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.130429e-02 1.504 0 0
DNA Double Strand Break Response R-HSA-5693606 3.443614e-02 1.463 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.054344e-02 1.515 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.013652e-02 1.521 0 0
Signaling by NOTCH4 R-HSA-9013694 3.407287e-02 1.468 0 0
Gap junction assembly R-HSA-190861 3.494538e-02 1.457 0 0
Signaling by VEGF R-HSA-194138 3.154642e-02 1.501 0 0
Homology Directed Repair R-HSA-5693538 3.054344e-02 1.515 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.809549e-02 1.551 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.494538e-02 1.457 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.392793e-02 1.469 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.169773e-02 1.499 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.256675e-02 1.487 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.883295e-02 1.540 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.207730e-02 1.494 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.169773e-02 1.499 0 0
IRAK1 recruits IKK complex R-HSA-937039 3.024501e-02 1.519 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 3.024501e-02 1.519 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.024501e-02 1.519 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.802576e-02 1.552 0 0
Metabolism of non-coding RNA R-HSA-194441 3.130429e-02 1.504 0 0
snRNP Assembly R-HSA-191859 3.130429e-02 1.504 0 0
Interferon Signaling R-HSA-913531 3.290518e-02 1.483 0 0
PKR-mediated signaling R-HSA-9833482 3.077418e-02 1.512 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.802576e-02 1.552 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.847853e-02 1.545 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.169773e-02 1.499 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.646138e-02 1.438 0 0
PKMTs methylate histone lysines R-HSA-3214841 3.667826e-02 1.436 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.709989e-02 1.431 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.709989e-02 1.431 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.763153e-02 1.424 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.771239e-02 1.424 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.773060e-02 1.423 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.027779e-02 1.395 0 0
Signaling by ROBO receptors R-HSA-376176 4.035848e-02 1.394 1 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 4.044168e-02 1.393 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.113600e-02 1.386 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.137873e-02 1.383 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.137873e-02 1.383 0 0
Oligomerization of connexins into connexons R-HSA-190704 4.165687e-02 1.380 0 0
Transport of connexins along the secretory pathway R-HSA-190827 4.165687e-02 1.380 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.165687e-02 1.380 0 0
Cellular Senescence R-HSA-2559583 4.201701e-02 1.377 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.202557e-02 1.376 0 0
HCMV Early Events R-HSA-9609690 4.234538e-02 1.373 0 0
Interleukin-37 signaling R-HSA-9008059 4.249888e-02 1.372 0 0
RET signaling R-HSA-8853659 4.475887e-02 1.349 0 0
G1/S-Specific Transcription R-HSA-69205 4.475887e-02 1.349 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.576792e-02 1.339 0 0
Signaling by PTK6 R-HSA-8848021 4.576792e-02 1.339 0 0
Semaphorin interactions R-HSA-373755 4.576792e-02 1.339 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.595066e-02 1.338 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.627095e-02 1.335 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.627095e-02 1.335 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.636705e-02 1.334 0 0
Degradation of CDH1 R-HSA-9766229 4.638284e-02 1.334 0 0
DNA Damage Bypass R-HSA-73893 4.638284e-02 1.334 0 0
Gap junction trafficking and regulation R-HSA-157858 4.638284e-02 1.334 0 0
Translesion Synthesis by POLH R-HSA-110320 4.648075e-02 1.333 0 0
Cell junction organization R-HSA-446728 4.706672e-02 1.327 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.568574e-02 1.254 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.568574e-02 1.254 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.568574e-02 1.254 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.568574e-02 1.254 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.568574e-02 1.254 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.255103e-02 1.279 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.545914e-02 1.256 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.545914e-02 1.256 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.447751e-02 1.264 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 5.925300e-02 1.227 0 0
EGFR downregulation R-HSA-182971 4.839305e-02 1.315 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 5.029340e-02 1.298 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.803883e-02 1.236 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.019788e-02 1.220 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.394477e-02 1.268 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.447751e-02 1.264 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.925300e-02 1.227 0 0
ERK/MAPK targets R-HSA-198753 6.325593e-02 1.199 0 0
Nephrin family interactions R-HSA-373753 5.447751e-02 1.264 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.568574e-02 1.254 0 0
EPH-Ephrin signaling R-HSA-2682334 5.203583e-02 1.284 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.267462e-02 1.203 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.383063e-02 1.269 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.383063e-02 1.269 0 0
Gene expression (Transcription) R-HSA-74160 5.757411e-02 1.240 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.545914e-02 1.256 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.447751e-02 1.264 0 0
Signaling by SCF-KIT R-HSA-1433557 5.113171e-02 1.291 0 0
Signaling by Hedgehog R-HSA-5358351 4.986400e-02 1.302 0 0
Negative regulation of MET activity R-HSA-6807004 5.447751e-02 1.264 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.157832e-02 1.288 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.262449e-02 1.203 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.895511e-02 1.310 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.171092e-02 1.210 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.280681e-02 1.277 0 0
Signaling by Leptin R-HSA-2586552 5.255103e-02 1.279 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.316318e-02 1.274 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.179320e-02 1.286 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.037467e-02 1.219 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.568574e-02 1.254 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.368822e-02 1.196 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.449286e-02 1.190 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.449286e-02 1.190 0 0
ChREBP activates metabolic gene expression R-HSA-163765 6.519874e-02 1.186 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.591798e-02 1.181 0 0
ESR-mediated signaling R-HSA-8939211 6.610647e-02 1.180 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.617613e-02 1.179 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.734040e-02 1.172 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.776462e-02 1.169 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.776462e-02 1.169 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.894856e-02 1.161 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.894856e-02 1.161 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.894856e-02 1.161 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.894856e-02 1.161 0 0
Signaling by RAS mutants R-HSA-6802949 6.894856e-02 1.161 0 0
Regulation of TP53 Expression R-HSA-6804754 6.912273e-02 1.160 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 6.912273e-02 1.160 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.912273e-02 1.160 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.951732e-02 1.158 0 0
Glycogen metabolism R-HSA-8982491 6.951732e-02 1.158 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.961330e-02 1.157 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.092594e-02 1.149 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.092594e-02 1.149 0 0
Interleukin-12 signaling R-HSA-9020591 7.245645e-02 1.140 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.281856e-02 1.138 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.281856e-02 1.138 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.281856e-02 1.138 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.313807e-02 1.136 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 7.347078e-02 1.134 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.396071e-02 1.131 0 0
Translation initiation complex formation R-HSA-72649 7.396071e-02 1.131 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.472202e-02 1.127 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.566360e-02 1.121 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.605846e-02 1.119 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.621173e-02 1.118 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.681809e-02 1.115 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.681809e-02 1.115 0 0
Adipogenesis R-HSA-9843745 7.686287e-02 1.114 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 7.711479e-02 1.113 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.711479e-02 1.113 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 7.739898e-02 1.111 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 7.795434e-02 1.108 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.928254e-02 1.101 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.928254e-02 1.101 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.928254e-02 1.101 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.003309e-02 1.097 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.050466e-02 1.094 0 0
Circadian clock R-HSA-9909396 8.107725e-02 1.091 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 8.112588e-02 1.091 0 0
Notch-HLH transcription pathway R-HSA-350054 8.316148e-02 1.080 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.316148e-02 1.080 0 0
G alpha (12/13) signalling events R-HSA-416482 8.362854e-02 1.078 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.457005e-02 1.073 0 0
MAP2K and MAPK activation R-HSA-5674135 8.457005e-02 1.073 0 0
Signaling by FGFR1 in disease R-HSA-5655302 8.457005e-02 1.073 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.540622e-02 1.069 0 0
Late endosomal microautophagy R-HSA-9615710 8.540622e-02 1.069 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.540622e-02 1.069 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.540622e-02 1.069 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.540622e-02 1.069 0 0
Protein folding R-HSA-391251 8.708325e-02 1.060 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.729191e-02 1.059 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.729191e-02 1.059 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.739827e-02 1.058 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.739827e-02 1.058 0 0
NRAGE signals death through JNK R-HSA-193648 8.739827e-02 1.058 0 0
Sensory processing of sound R-HSA-9659379 8.960411e-02 1.048 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 8.988255e-02 1.046 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.988255e-02 1.046 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.277309e-02 1.033 0 0
HIV Life Cycle R-HSA-162587 9.338437e-02 1.030 0 0
SOS-mediated signalling R-HSA-112412 9.343594e-02 1.029 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.014203e-01 0.994 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.014203e-01 0.994 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.014203e-01 0.994 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.008757e-01 0.996 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.357647e-01 0.867 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.357647e-01 0.867 0 0
RSK activation R-HSA-444257 1.153549e-01 0.938 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 9.474295e-02 1.023 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 9.474295e-02 1.023 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 9.474295e-02 1.023 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 9.474295e-02 1.023 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 9.474295e-02 1.023 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 9.474295e-02 1.023 0 0
ARMS-mediated activation R-HSA-170984 1.389843e-01 0.857 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.389843e-01 0.857 0 0
ALK mutants bind TKIs R-HSA-9700645 1.389843e-01 0.857 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.115035e-01 0.953 0 0
Formation of axial mesoderm R-HSA-9796292 1.115035e-01 0.953 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.294742e-01 0.888 0 0
GAB1 signalosome R-HSA-180292 1.033392e-01 0.986 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.330099e-01 0.876 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.059670e-01 0.975 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.462206e-02 1.024 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.289375e-01 0.890 0 0
Regulation of CDH1 Function R-HSA-9764561 9.464220e-02 1.024 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.022359e-01 0.990 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.151405e-01 0.939 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.151405e-01 0.939 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 1.151405e-01 0.939 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.404131e-01 0.853 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.148095e-01 0.940 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.361164e-01 0.866 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.361164e-01 0.866 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.239271e-01 0.907 0 0
RNA Polymerase III Transcription R-HSA-74158 9.462206e-02 1.024 0 0
Cellular response to hypoxia R-HSA-1234174 9.797016e-02 1.009 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.041579e-01 0.982 0 0
Gap junction trafficking R-HSA-190828 1.105220e-01 0.957 0 0
Metalloprotease DUBs R-HSA-5689901 1.320477e-01 0.879 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.171586e-01 0.931 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.115035e-01 0.953 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.033392e-01 0.986 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.427458e-02 1.026 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.482996e-02 1.023 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.287681e-01 0.890 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.374330e-02 1.028 0 0
Long-term potentiation R-HSA-9620244 1.187417e-01 0.925 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.064622e-01 0.973 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 1.008757e-01 0.996 0 0
NADE modulates death signalling R-HSA-205025 1.357647e-01 0.867 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.177304e-01 0.929 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.289375e-01 0.890 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.294742e-01 0.888 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.375755e-01 0.861 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.174637e-01 0.930 0 0
DNA Replication R-HSA-69306 1.129526e-01 0.947 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.289375e-01 0.890 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.242027e-01 0.906 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.289375e-01 0.890 0 0
Interleukin-1 family signaling R-HSA-446652 1.079793e-01 0.967 0 0
Metabolism of RNA R-HSA-8953854 1.010642e-01 0.995 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.357647e-01 0.867 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.357647e-01 0.867 0 0
Signaling by FGFR4 R-HSA-5654743 1.014251e-01 0.994 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.142063e-01 0.942 0 0
Signaling by FGFR3 R-HSA-5654741 1.200579e-01 0.921 0 0
Rap1 signalling R-HSA-392517 1.177304e-01 0.929 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.173601e-01 0.930 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.153549e-01 0.938 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.389843e-01 0.857 0 0
Protein hydroxylation R-HSA-9629569 1.330099e-01 0.876 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.105220e-01 0.957 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.233216e-01 0.909 0 0
Diseases of DNA repair R-HSA-9675135 1.300248e-01 0.886 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.375755e-01 0.861 0 0
Glycolysis R-HSA-70171 9.364202e-02 1.029 0 0
Glycogen synthesis R-HSA-3322077 1.330099e-01 0.876 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.406915e-01 0.852 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.412843e-01 0.850 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.412843e-01 0.850 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.436468e-01 0.843 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.449040e-01 0.839 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.460287e-01 0.836 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.460287e-01 0.836 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 1.460287e-01 0.836 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.464082e-01 0.834 0 0
Hedgehog 'on' state R-HSA-5632684 1.464082e-01 0.834 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.473160e-01 0.832 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.473160e-01 0.832 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.485542e-01 0.828 0 0
DCC mediated attractive signaling R-HSA-418885 1.485542e-01 0.828 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.485542e-01 0.828 0 0
Protein methylation R-HSA-8876725 1.485542e-01 0.828 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.491246e-01 0.826 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.505471e-01 0.822 0 0
Co-stimulation by CD28 R-HSA-389356 1.512114e-01 0.820 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.518743e-01 0.819 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.518743e-01 0.819 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.518809e-01 0.818 0 0
Interleukin-1 signaling R-HSA-9020702 1.531568e-01 0.815 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.536225e-01 0.814 0 0
TNF signaling R-HSA-75893 1.536225e-01 0.814 0 0
Signaling by FGFR1 R-HSA-5654736 1.536225e-01 0.814 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.536225e-01 0.814 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.536990e-01 0.813 0 0
RAF activation R-HSA-5673000 1.541766e-01 0.812 0 0
Signal amplification R-HSA-392518 1.541766e-01 0.812 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.541766e-01 0.812 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 1.541766e-01 0.812 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.541766e-01 0.812 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.541766e-01 0.812 0 0
Mitophagy R-HSA-5205647 1.541766e-01 0.812 0 0
Calnexin/calreticulin cycle R-HSA-901042 1.541766e-01 0.812 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.549689e-01 0.810 0 0
Interleukin-12 family signaling R-HSA-447115 1.550428e-01 0.810 0 0
Signaling by MET R-HSA-6806834 1.555106e-01 0.808 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.564301e-01 0.806 0 0
HIV Infection R-HSA-162906 1.588917e-01 0.799 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.606493e-01 0.794 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.640738e-01 0.785 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.640738e-01 0.785 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.640738e-01 0.785 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 1.640738e-01 0.785 0 0
Regulation of CDH11 function R-HSA-9762292 1.640738e-01 0.785 0 0
Signal attenuation R-HSA-74749 1.640738e-01 0.785 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.640738e-01 0.785 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.649933e-01 0.783 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.649933e-01 0.783 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.660159e-01 0.780 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.660159e-01 0.780 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.660159e-01 0.780 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.660159e-01 0.780 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.660159e-01 0.780 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.675893e-01 0.776 0 0
Regulation of Apoptosis R-HSA-169911 1.675893e-01 0.776 0 0
Oncogene Induced Senescence R-HSA-2559585 1.675893e-01 0.776 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.675893e-01 0.776 0 0
Phosphorylation of the APC/C R-HSA-176412 1.686349e-01 0.773 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.686349e-01 0.773 0 0
Prolonged ERK activation events R-HSA-169893 1.686349e-01 0.773 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.686349e-01 0.773 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.686349e-01 0.773 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.702619e-01 0.769 0 0
Influenza Infection R-HSA-168255 1.707311e-01 0.768 0 0
Ca-dependent events R-HSA-111996 1.717085e-01 0.765 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.728278e-01 0.762 0 0
IRS activation R-HSA-74713 1.728278e-01 0.762 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.728278e-01 0.762 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.728278e-01 0.762 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 1.728278e-01 0.762 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.739847e-01 0.759 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.925600e-01 0.715 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.925600e-01 0.715 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.925600e-01 0.715 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.925600e-01 0.715 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.925600e-01 0.715 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 1.925600e-01 0.715 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.925600e-01 0.715 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.925600e-01 0.715 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.925600e-01 0.715 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 1.925600e-01 0.715 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.925600e-01 0.715 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.925600e-01 0.715 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.744604e-01 0.562 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 2.744604e-01 0.562 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 2.744604e-01 0.562 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.744604e-01 0.562 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.744604e-01 0.562 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 2.744604e-01 0.562 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.744604e-01 0.562 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.744604e-01 0.562 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.744604e-01 0.562 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 2.744604e-01 0.562 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.744604e-01 0.562 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 2.112658e-01 0.675 0 0
Phosphorylation of Emi1 R-HSA-176417 2.112658e-01 0.675 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.480579e-01 0.458 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.480579e-01 0.458 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.480579e-01 0.458 0 0
Signalling to ERK5 R-HSA-198765 3.480579e-01 0.458 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.480579e-01 0.458 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.480579e-01 0.458 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.480579e-01 0.458 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.480579e-01 0.458 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.480579e-01 0.458 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.480579e-01 0.458 0 0
Potassium transport channels R-HSA-1296067 3.480579e-01 0.458 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 3.480579e-01 0.458 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.480579e-01 0.458 0 0
Defective visual phototransduction due to STRA6 loss of function R-HSA-9918449 3.480579e-01 0.458 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.480579e-01 0.458 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.480579e-01 0.458 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.480579e-01 0.458 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.504191e-01 0.601 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.504191e-01 0.601 0 0
STAT5 Activation R-HSA-9645135 2.504191e-01 0.601 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.504191e-01 0.601 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.504191e-01 0.601 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.504191e-01 0.601 0 0
Signaling by APC mutants R-HSA-4839744 1.903738e-01 0.720 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.903738e-01 0.720 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.903738e-01 0.720 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.903738e-01 0.720 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.176406e-01 0.662 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.176406e-01 0.662 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.176406e-01 0.662 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 2.897476e-01 0.538 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.897476e-01 0.538 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 2.897476e-01 0.538 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 2.897476e-01 0.538 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 2.897476e-01 0.538 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.897476e-01 0.538 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.897476e-01 0.538 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.896024e-01 0.722 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.456415e-01 0.610 0 0
Pervasive developmental disorders R-HSA-9005895 2.456415e-01 0.610 0 0
Disorders of Nervous System Development R-HSA-9697154 2.456415e-01 0.610 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.456415e-01 0.610 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.113399e-01 0.675 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.288132e-01 0.483 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.288132e-01 0.483 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.288132e-01 0.483 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.741570e-01 0.562 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.741570e-01 0.562 0 0
Polo-like kinase mediated events R-HSA-156711 2.337295e-01 0.631 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.337295e-01 0.631 0 0
Ephrin signaling R-HSA-3928664 2.337295e-01 0.631 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.337295e-01 0.631 0 0
Thromboxane signalling through TP receptor R-HSA-428930 2.206992e-01 0.656 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.206992e-01 0.656 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.566543e-01 0.591 0 0
Removal of the Flap Intermediate R-HSA-69166 3.029834e-01 0.519 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.400332e-01 0.620 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.799998e-01 0.553 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.799998e-01 0.553 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.799998e-01 0.553 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.799998e-01 0.553 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.799998e-01 0.553 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.247100e-01 0.648 0 0
Erythropoietin activates RAS R-HSA-9027284 3.319340e-01 0.479 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.319340e-01 0.479 0 0
Dual incision in TC-NER R-HSA-6782135 1.750034e-01 0.757 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 2.799325e-01 0.553 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.799325e-01 0.553 0 0
Cristae formation R-HSA-8949613 2.799325e-01 0.553 0 0
Striated Muscle Contraction R-HSA-390522 2.594494e-01 0.586 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.253391e-01 0.647 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.396164e-01 0.620 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.734912e-01 0.563 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.734912e-01 0.563 0 0
Signaling by Erythropoietin R-HSA-9006335 3.209995e-01 0.493 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.362482e-01 0.473 0 0
Neutrophil degranulation R-HSA-6798695 2.623261e-01 0.581 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.417981e-01 0.466 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 2.598016e-01 0.585 0 0
Nucleotide Excision Repair R-HSA-5696398 1.941724e-01 0.712 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.113399e-01 0.675 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.113399e-01 0.675 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.916513e-01 0.717 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.113399e-01 0.675 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.414216e-01 0.617 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.456415e-01 0.610 0 0
G-protein beta:gamma signalling R-HSA-397795 2.418939e-01 0.616 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.052704e-01 0.688 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.836204e-01 0.736 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.029834e-01 0.519 0 0
Degradation of DVL R-HSA-4641258 1.958631e-01 0.708 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.319340e-01 0.479 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.113840e-01 0.675 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.417981e-01 0.466 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.234143e-01 0.490 0 0
RNA Polymerase I Transcription R-HSA-73864 3.172952e-01 0.499 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.418939e-01 0.616 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.734912e-01 0.563 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.993987e-01 0.524 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.189140e-01 0.660 0 0
Cellular response to starvation R-HSA-9711097 3.368363e-01 0.473 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.907225e-01 0.537 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 2.112658e-01 0.675 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.897476e-01 0.538 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 1.836204e-01 0.736 0 0
HDACs deacetylate histones R-HSA-3214815 2.370107e-01 0.625 0 0
Adherens junctions interactions R-HSA-418990 2.645783e-01 0.577 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.916513e-01 0.717 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.029834e-01 0.519 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.734912e-01 0.563 0 0
Mismatch Repair R-HSA-5358508 2.337295e-01 0.631 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.112658e-01 0.675 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.896024e-01 0.722 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.018713e-01 0.695 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.319340e-01 0.479 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.418939e-01 0.616 0 0
PCP/CE pathway R-HSA-4086400 3.172952e-01 0.499 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.252515e-01 0.647 0 0
UCH proteinases R-HSA-5689603 1.948034e-01 0.710 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.714022e-01 0.566 0 0
Heme signaling R-HSA-9707616 3.358969e-01 0.474 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.108476e-01 0.676 0 0
Cyclin D associated events in G1 R-HSA-69231 3.234143e-01 0.490 0 0
G1 Phase R-HSA-69236 3.234143e-01 0.490 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.258605e-01 0.646 0 0
RNA Polymerase II Transcription R-HSA-73857 3.139431e-01 0.503 0 0
Neurexins and neuroligins R-HSA-6794361 1.982229e-01 0.703 0 0
DNA Repair R-HSA-73894 1.748917e-01 0.757 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.896024e-01 0.722 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.916513e-01 0.717 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.113840e-01 0.675 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.414216e-01 0.617 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.573106e-01 0.590 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.954769e-01 0.529 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.253391e-01 0.647 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.996383e-01 0.523 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.690292e-01 0.570 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.690292e-01 0.570 0 0
PLC beta mediated events R-HSA-112043 2.094859e-01 0.679 0 0
Frs2-mediated activation R-HSA-170968 2.741570e-01 0.562 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.723717e-01 0.565 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.488251e-01 0.604 0 0
Stabilization of p53 R-HSA-69541 2.258605e-01 0.646 0 0
Intra-Golgi traffic R-HSA-6811438 2.734912e-01 0.563 0 0
HATs acetylate histones R-HSA-3214847 2.063028e-01 0.685 0 0
Signalling to ERKs R-HSA-187687 2.954769e-01 0.529 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.504191e-01 0.601 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.288132e-01 0.483 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.845443e-01 0.734 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.258605e-01 0.646 0 0
Calmodulin induced events R-HSA-111933 1.814947e-01 0.741 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.088398e-01 0.510 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.799325e-01 0.553 0 0
Signaling by TGFB family members R-HSA-9006936 2.763655e-01 0.559 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.189140e-01 0.660 0 0
HCMV Infection R-HSA-9609646 3.029721e-01 0.519 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.845443e-01 0.734 0 0
CaM pathway R-HSA-111997 1.814947e-01 0.741 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.423288e-01 0.616 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.358969e-01 0.474 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.434369e-01 0.464 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.659925e-01 0.575 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.744604e-01 0.562 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.744604e-01 0.562 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 2.112658e-01 0.675 0 0
Interleukin-33 signaling R-HSA-9014843 3.480579e-01 0.458 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.480579e-01 0.458 0 0
Signaling by AXIN mutants R-HSA-4839735 2.176406e-01 0.662 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.176406e-01 0.662 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.741570e-01 0.562 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.337295e-01 0.631 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.206992e-01 0.656 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.029834e-01 0.519 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.079465e-01 0.682 0 0
Interleukin-7 signaling R-HSA-1266695 2.400332e-01 0.620 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.106628e-01 0.676 0 0
DAG and IP3 signaling R-HSA-1489509 2.113840e-01 0.675 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.113840e-01 0.675 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.396164e-01 0.620 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.138499e-01 0.503 0 0
Degradation of AXIN R-HSA-4641257 3.323971e-01 0.478 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.323971e-01 0.478 0 0
Signaling by FGFR2 R-HSA-5654738 3.434369e-01 0.464 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.947282e-01 0.531 0 0
G-protein mediated events R-HSA-112040 2.856058e-01 0.544 0 0
Integration of energy metabolism R-HSA-163685 2.876030e-01 0.541 0 0
Interleukin-15 signaling R-HSA-8983432 2.456415e-01 0.610 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.113364e-01 0.507 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.995980e-01 0.700 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.896024e-01 0.722 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.771707e-01 0.752 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 3.003550e-01 0.522 0 0
Developmental Biology R-HSA-1266738 2.285743e-01 0.641 1 0
Signaling by NTRKs R-HSA-166520 1.831304e-01 0.737 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 2.112658e-01 0.675 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 2.112658e-01 0.675 0 0
Nef and signal transduction R-HSA-164944 2.504191e-01 0.601 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.897476e-01 0.538 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.594494e-01 0.586 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.773269e-01 0.557 0 0
Smooth Muscle Contraction R-HSA-445355 3.304950e-01 0.481 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.403931e-01 0.468 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.403931e-01 0.468 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.504191e-01 0.601 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.288132e-01 0.483 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.690292e-01 0.570 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.358969e-01 0.474 0 0
TCR signaling R-HSA-202403 2.398375e-01 0.620 0 0
Signal regulatory protein family interactions R-HSA-391160 3.029834e-01 0.519 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.982229e-01 0.703 0 0
FOXO-mediated transcription R-HSA-9614085 2.063028e-01 0.685 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.896024e-01 0.722 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.896024e-01 0.722 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.993987e-01 0.524 0 0
Signaling by Interleukins R-HSA-449147 2.131441e-01 0.671 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.480579e-01 0.458 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.897476e-01 0.538 0 0
Sodium/Proton exchangers R-HSA-425986 3.288132e-01 0.483 0 0
Assembly Of The HIV Virion R-HSA-175474 3.275129e-01 0.485 0 0
Zinc transporters R-HSA-435354 3.029834e-01 0.519 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.258605e-01 0.646 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.799325e-01 0.553 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.896024e-01 0.722 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.337295e-01 0.631 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.158600e-01 0.501 0 0
Nephron development R-HSA-9831926 2.337295e-01 0.631 0 0
Suppression of phagosomal maturation R-HSA-9637687 2.598016e-01 0.585 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.065799e-01 0.513 0 0
Glucose metabolism R-HSA-70326 2.441288e-01 0.612 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.418939e-01 0.616 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 3.036548e-01 0.518 0 0
SARS-CoV Infections R-HSA-9679506 2.583734e-01 0.588 0 0
Translation of Structural Proteins R-HSA-9683701 2.734912e-01 0.563 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.211535e-01 0.493 0 0
Gene Silencing by RNA R-HSA-211000 2.966916e-01 0.528 0 0
SARS-CoV-1 Infection R-HSA-9678108 2.000822e-01 0.699 0 0
Glycogen storage diseases R-HSA-3229121 2.113399e-01 0.675 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 3.482421e-01 0.458 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.482421e-01 0.458 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.499723e-01 0.456 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.506475e-01 0.455 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.513696e-01 0.454 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.513696e-01 0.454 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.514730e-01 0.454 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.540260e-01 0.451 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.574802e-01 0.447 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.574802e-01 0.447 0 0
Signaling by TGFBR3 R-HSA-9839373 3.574802e-01 0.447 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.608393e-01 0.443 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.608393e-01 0.443 0 0
Trafficking of AMPA receptors R-HSA-399719 3.626855e-01 0.440 0 0
Budding and maturation of HIV virion R-HSA-162588 3.626855e-01 0.440 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.626855e-01 0.440 0 0
Downstream signal transduction R-HSA-186763 3.626855e-01 0.440 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.646584e-01 0.438 0 0
Lipophagy R-HSA-9613354 3.672649e-01 0.435 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 3.672649e-01 0.435 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.672649e-01 0.435 0 0
Calcineurin activates NFAT R-HSA-2025928 3.672649e-01 0.435 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.672649e-01 0.435 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.672649e-01 0.435 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.754401e-01 0.425 0 0
Syndecan interactions R-HSA-3000170 3.754401e-01 0.425 0 0
Growth hormone receptor signaling R-HSA-982772 3.754401e-01 0.425 0 0
Cell-cell junction organization R-HSA-421270 3.773595e-01 0.423 0 0
Signaling by FGFR in disease R-HSA-1226099 3.820826e-01 0.418 0 0
Signaling by WNT in cancer R-HSA-4791275 3.835991e-01 0.416 0 0
G0 and Early G1 R-HSA-1538133 3.835991e-01 0.416 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.839748e-01 0.416 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.886115e-01 0.410 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.886115e-01 0.410 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.895476e-01 0.409 0 0
Disorders of Developmental Biology R-HSA-9675151 3.895476e-01 0.409 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.895476e-01 0.409 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 3.895476e-01 0.409 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 3.895476e-01 0.409 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.918385e-01 0.407 0 0
Intraflagellar transport R-HSA-5620924 3.918385e-01 0.407 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.922807e-01 0.406 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 3.939524e-01 0.405 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.959858e-01 0.402 0 0
Protein ubiquitination R-HSA-8852135 3.961816e-01 0.402 0 0
Iron uptake and transport R-HSA-917937 3.961816e-01 0.402 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.968680e-01 0.401 0 0
IRE1alpha activates chaperones R-HSA-381070 3.968680e-01 0.401 0 0
Deadenylation of mRNA R-HSA-429947 3.993257e-01 0.399 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.993257e-01 0.399 0 0
Complex III assembly R-HSA-9865881 3.993257e-01 0.399 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.993257e-01 0.399 0 0
Neurodegenerative Diseases R-HSA-8863678 3.993257e-01 0.399 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.993257e-01 0.399 0 0
Nuclear RNA decay R-HSA-9930044 4.044791e-01 0.393 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.044791e-01 0.393 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.044791e-01 0.393 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.048254e-01 0.393 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.048254e-01 0.393 0 0
DNA replication initiation R-HSA-68952 4.048254e-01 0.393 0 0
PI3K/AKT activation R-HSA-198203 4.048254e-01 0.393 0 0
2-LTR circle formation R-HSA-164843 4.048254e-01 0.393 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.073900e-01 0.390 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.073900e-01 0.390 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.099176e-01 0.387 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.099176e-01 0.387 0 0
Meiosis R-HSA-1500620 4.100722e-01 0.387 0 0
MAPK family signaling cascades R-HSA-5683057 4.101669e-01 0.387 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.103027e-01 0.387 0 0
FasL/ CD95L signaling R-HSA-75157 4.141937e-01 0.383 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 4.141937e-01 0.383 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.141937e-01 0.383 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.141937e-01 0.383 0 0
MET activates PTPN11 R-HSA-8865999 4.141937e-01 0.383 0 0
Invadopodia formation R-HSA-8941237 4.141937e-01 0.383 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 4.141937e-01 0.383 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 4.141937e-01 0.383 0 0
Classical Kir channels R-HSA-1296053 4.141937e-01 0.383 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 4.141937e-01 0.383 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 4.161242e-01 0.381 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.179245e-01 0.379 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 4.179245e-01 0.379 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.230477e-01 0.374 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.230477e-01 0.374 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 4.230477e-01 0.374 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 4.230477e-01 0.374 0 0
G protein gated Potassium channels R-HSA-1296059 4.230477e-01 0.374 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.230477e-01 0.374 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.230477e-01 0.374 0 0
TGFBR3 expression R-HSA-9839394 4.230477e-01 0.374 0 0
Gastrulation R-HSA-9758941 4.244351e-01 0.372 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.252413e-01 0.371 0 0
Regulated Necrosis R-HSA-5218859 4.252413e-01 0.371 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.252694e-01 0.371 0 0
Acyl chain remodelling of PC R-HSA-1482788 4.252694e-01 0.371 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.258699e-01 0.371 0 0
Peroxisomal protein import R-HSA-9033241 4.258699e-01 0.371 0 0
Muscle contraction R-HSA-397014 4.318047e-01 0.365 0 0
PI Metabolism R-HSA-1483255 4.336552e-01 0.363 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.412801e-01 0.355 0 0
Formation of the posterior neural plate R-HSA-9832991 4.412801e-01 0.355 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 4.412801e-01 0.355 0 0
Bicarbonate transporters R-HSA-425381 4.412801e-01 0.355 0 0
Interleukin-2 signaling R-HSA-9020558 4.412801e-01 0.355 0 0
Suppression of apoptosis R-HSA-9635465 4.412801e-01 0.355 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.412801e-01 0.355 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 4.458524e-01 0.351 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.458524e-01 0.351 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.458524e-01 0.351 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.458524e-01 0.351 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.458524e-01 0.351 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.458524e-01 0.351 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 4.458524e-01 0.351 0 0
Platelet sensitization by LDL R-HSA-432142 4.458524e-01 0.351 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.459171e-01 0.351 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 4.459171e-01 0.351 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.465314e-01 0.350 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.532365e-01 0.344 0 0
Signaling by WNT R-HSA-195721 4.549591e-01 0.342 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.576352e-01 0.339 0 0
Opioid Signalling R-HSA-111885 4.581630e-01 0.339 0 0
TBC/RABGAPs R-HSA-8854214 4.632644e-01 0.334 0 0
Peptide chain elongation R-HSA-156902 4.636414e-01 0.334 0 0
PERK regulates gene expression R-HSA-381042 4.663732e-01 0.331 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.663732e-01 0.331 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.697087e-01 0.328 0 0
Insulin processing R-HSA-264876 4.697087e-01 0.328 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.732297e-01 0.325 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.732297e-01 0.325 0 0
The NLRP3 inflammasome R-HSA-844456 4.732297e-01 0.325 0 0
Other interleukin signaling R-HSA-449836 4.732297e-01 0.325 0 0
NCAM signaling for neurite out-growth R-HSA-375165 4.734005e-01 0.325 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.736238e-01 0.325 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.736238e-01 0.325 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.736238e-01 0.325 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.736238e-01 0.325 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.736238e-01 0.325 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.736238e-01 0.325 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 4.736238e-01 0.325 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.736238e-01 0.325 0 0
Sensory perception of sour taste R-HSA-9729555 4.736238e-01 0.325 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 4.736238e-01 0.325 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.736238e-01 0.325 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 4.764668e-01 0.322 0 0
ERKs are inactivated R-HSA-202670 4.764668e-01 0.322 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.764668e-01 0.322 0 0
Integration of provirus R-HSA-162592 4.764668e-01 0.322 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.764668e-01 0.322 0 0
Meiotic synapsis R-HSA-1221632 4.772721e-01 0.321 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.772721e-01 0.321 0 0
Amino acids regulate mTORC1 R-HSA-9639288 4.772721e-01 0.321 0 0
Deubiquitination R-HSA-5688426 4.811649e-01 0.318 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.816106e-01 0.317 0 0
Netrin-1 signaling R-HSA-373752 4.816106e-01 0.317 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.890574e-01 0.311 0 0
Downstream TCR signaling R-HSA-202424 4.901806e-01 0.310 0 0
Ribosome-associated quality control R-HSA-9948299 4.911853e-01 0.309 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.925185e-01 0.308 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.925185e-01 0.308 0 0
Signaling by FGFR R-HSA-190236 4.988236e-01 0.302 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.997607e-01 0.301 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.999699e-01 0.301 0 0
Cellular response to chemical stress R-HSA-9711123 5.099082e-01 0.293 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.102677e-01 0.292 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.102677e-01 0.292 0 0
Leading Strand Synthesis R-HSA-69109 5.102677e-01 0.292 0 0
Polymerase switching R-HSA-69091 5.102677e-01 0.292 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.102677e-01 0.292 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.102677e-01 0.292 0 0
MET activates RAS signaling R-HSA-8851805 5.102677e-01 0.292 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.102677e-01 0.292 0 0
Signaling by LTK R-HSA-9842663 5.102677e-01 0.292 0 0
OAS antiviral response R-HSA-8983711 5.102677e-01 0.292 0 0
Signaling by NOTCH R-HSA-157118 5.108124e-01 0.292 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 5.149066e-01 0.288 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.149066e-01 0.288 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.149066e-01 0.288 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.149066e-01 0.288 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.219717e-01 0.282 0 0
Lagging Strand Synthesis R-HSA-69186 5.260006e-01 0.279 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 5.260006e-01 0.279 0 0
Early Phase of HIV Life Cycle R-HSA-162594 5.260006e-01 0.279 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.260006e-01 0.279 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.260006e-01 0.279 0 0
Basigin interactions R-HSA-210991 5.260006e-01 0.279 0 0
MET promotes cell motility R-HSA-8875878 5.261565e-01 0.279 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.270279e-01 0.278 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.270279e-01 0.278 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.270279e-01 0.278 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.270279e-01 0.278 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.270279e-01 0.278 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.270279e-01 0.278 0 0
Defective F9 activation R-HSA-9673221 5.270279e-01 0.278 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.270279e-01 0.278 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.270279e-01 0.278 0 0
Activation of AKT2 R-HSA-165158 5.270279e-01 0.278 0 0
Reelin signalling pathway R-HSA-8866376 5.270279e-01 0.278 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.270279e-01 0.278 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.270279e-01 0.278 0 0
Interleukin-36 pathway R-HSA-9014826 5.270279e-01 0.278 0 0
NrCAM interactions R-HSA-447038 5.270279e-01 0.278 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.270279e-01 0.278 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.270279e-01 0.278 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.270279e-01 0.278 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.270279e-01 0.278 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.270279e-01 0.278 0 0
Ion homeostasis R-HSA-5578775 5.270423e-01 0.278 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.281679e-01 0.277 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.293746e-01 0.276 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.353526e-01 0.271 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.355280e-01 0.271 0 0
Neuronal System R-HSA-112316 5.356190e-01 0.271 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.368253e-01 0.270 0 0
Rab regulation of trafficking R-HSA-9007101 5.369103e-01 0.270 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.426019e-01 0.266 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.426019e-01 0.266 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.426019e-01 0.266 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.426019e-01 0.266 0 0
Processing of SMDT1 R-HSA-8949664 5.426019e-01 0.266 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.426019e-01 0.266 0 0
Maturation of nucleoprotein R-HSA-9683610 5.426019e-01 0.266 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.454299e-01 0.263 0 0
RAS processing R-HSA-9648002 5.454299e-01 0.263 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 5.512628e-01 0.259 0 0
Metal ion SLC transporters R-HSA-425410 5.527404e-01 0.257 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 5.549508e-01 0.256 0 0
Molecules associated with elastic fibres R-HSA-2129379 5.582333e-01 0.253 0 0
Protein localization R-HSA-9609507 5.585372e-01 0.253 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.643222e-01 0.248 0 0
Toll-like Receptor Cascades R-HSA-168898 5.673899e-01 0.246 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.675394e-01 0.246 0 0
Transmission across Chemical Synapses R-HSA-112315 5.678852e-01 0.246 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.692848e-01 0.245 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.734190e-01 0.242 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.734190e-01 0.242 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.734190e-01 0.242 0 0
Prolactin receptor signaling R-HSA-1170546 5.734190e-01 0.242 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.750167e-01 0.240 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.750167e-01 0.240 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.750167e-01 0.240 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.750167e-01 0.240 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.750167e-01 0.240 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.750167e-01 0.240 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.750167e-01 0.240 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.750167e-01 0.240 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.750167e-01 0.240 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.750167e-01 0.240 0 0
PKB-mediated events R-HSA-109703 5.750167e-01 0.240 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 5.750167e-01 0.240 0 0
PDE3B signalling R-HSA-165160 5.750167e-01 0.240 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.750167e-01 0.240 0 0
Intestinal hexose absorption R-HSA-8981373 5.750167e-01 0.240 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.750167e-01 0.240 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.750167e-01 0.240 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.750167e-01 0.240 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 5.750167e-01 0.240 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.750167e-01 0.240 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.750167e-01 0.240 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.750167e-01 0.240 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.750167e-01 0.240 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.750167e-01 0.240 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.757090e-01 0.240 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.757090e-01 0.240 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.757090e-01 0.240 0 0
Signaling by KIT in disease R-HSA-9669938 5.757090e-01 0.240 0 0
Cellular hexose transport R-HSA-189200 5.757090e-01 0.240 0 0
Inwardly rectifying K+ channels R-HSA-1296065 5.790951e-01 0.237 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.796138e-01 0.237 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.796195e-01 0.237 0 0
Eukaryotic Translation Termination R-HSA-72764 5.799814e-01 0.237 0 0
Generic Transcription Pathway R-HSA-212436 5.830383e-01 0.234 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.840564e-01 0.234 0 0
RSV-host interactions R-HSA-9833110 5.843756e-01 0.233 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.903218e-01 0.229 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 5.993029e-01 0.222 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 5.993814e-01 0.222 0 0
SHC1 events in EGFR signaling R-HSA-180336 6.026940e-01 0.220 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.026940e-01 0.220 0 0
DNA Damage Reversal R-HSA-73942 6.026940e-01 0.220 0 0
Formation of the anterior neural plate R-HSA-9823739 6.026940e-01 0.220 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.026940e-01 0.220 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.054670e-01 0.218 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.081064e-01 0.216 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.152066e-01 0.211 0 0
Regulation of insulin secretion R-HSA-422356 6.163369e-01 0.210 0 0
Signaling by LTK in cancer R-HSA-9842640 6.181389e-01 0.209 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.181389e-01 0.209 0 0
Defective CYP11A1 causes AICSR R-HSA-5579026 6.181389e-01 0.209 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.181389e-01 0.209 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.181389e-01 0.209 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.181389e-01 0.209 0 0
Lactose synthesis R-HSA-5653890 6.181389e-01 0.209 0 0
Abacavir transmembrane transport R-HSA-2161517 6.181389e-01 0.209 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.181389e-01 0.209 0 0
Neurofascin interactions R-HSA-447043 6.181389e-01 0.209 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.184623e-01 0.209 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.190516e-01 0.208 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.190516e-01 0.208 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.190679e-01 0.208 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 6.190679e-01 0.208 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.190679e-01 0.208 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.203123e-01 0.207 0 0
Interferon alpha/beta signaling R-HSA-909733 6.217894e-01 0.206 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.220181e-01 0.206 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.220181e-01 0.206 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.220181e-01 0.206 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.259446e-01 0.203 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.304227e-01 0.200 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.304227e-01 0.200 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.304227e-01 0.200 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.304227e-01 0.200 0 0
Adaptive Immune System R-HSA-1280218 6.317620e-01 0.199 0 0
Ion channel transport R-HSA-983712 6.336612e-01 0.198 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.347311e-01 0.197 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.381355e-01 0.195 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.438369e-01 0.191 0 0
Co-inhibition by PD-1 R-HSA-389948 6.444749e-01 0.191 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.460930e-01 0.190 0 0
Ion transport by P-type ATPases R-HSA-936837 6.490559e-01 0.188 0 0
RMTs methylate histone arginines R-HSA-3214858 6.522488e-01 0.186 0 0
Acyl chain remodelling of PE R-HSA-1482839 6.565699e-01 0.183 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.566173e-01 0.183 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.566173e-01 0.183 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.566173e-01 0.183 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.566173e-01 0.183 0 0
Coenzyme A biosynthesis R-HSA-196783 6.566173e-01 0.183 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.568879e-01 0.183 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.568879e-01 0.183 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.568879e-01 0.183 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.568879e-01 0.183 0 0
Disinhibition of SNARE formation R-HSA-114516 6.568879e-01 0.183 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.568879e-01 0.183 0 0
PTK6 Expression R-HSA-8849473 6.568879e-01 0.183 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.568879e-01 0.183 0 0
Electron transport from NADPH to Ferredoxin R-HSA-2395516 6.568879e-01 0.183 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.568879e-01 0.183 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.568879e-01 0.183 0 0
VLDL clearance R-HSA-8964046 6.568879e-01 0.183 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.568879e-01 0.183 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.568879e-01 0.183 0 0
Netrin mediated repulsion signals R-HSA-418886 6.568879e-01 0.183 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.568879e-01 0.183 0 0
CHL1 interactions R-HSA-447041 6.568879e-01 0.183 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.568879e-01 0.183 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.568879e-01 0.183 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.622566e-01 0.179 0 0
Neddylation R-HSA-8951664 6.645420e-01 0.177 0 0
Myogenesis R-HSA-525793 6.647494e-01 0.177 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.647494e-01 0.177 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 6.647494e-01 0.177 0 0
Nucleosome assembly R-HSA-774815 6.684084e-01 0.175 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.684084e-01 0.175 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.684084e-01 0.175 0 0
Somitogenesis R-HSA-9824272 6.684084e-01 0.175 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.684084e-01 0.175 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.743608e-01 0.171 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.743608e-01 0.171 0 0
RUNX2 regulates bone development R-HSA-8941326 6.743608e-01 0.171 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.813036e-01 0.167 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.813036e-01 0.167 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.813036e-01 0.167 0 0
Catecholamine biosynthesis R-HSA-209905 6.813036e-01 0.167 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.813036e-01 0.167 0 0
Specification of primordial germ cells R-HSA-9827857 6.813036e-01 0.167 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.847529e-01 0.164 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.847529e-01 0.164 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.847529e-01 0.164 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 6.917070e-01 0.160 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.917070e-01 0.160 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.917070e-01 0.160 0 0
phospho-PLA2 pathway R-HSA-111995 6.917070e-01 0.160 0 0
MET receptor recycling R-HSA-8875656 6.917070e-01 0.160 0 0
Formation of annular gap junctions R-HSA-196025 6.917070e-01 0.160 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.917070e-01 0.160 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.917070e-01 0.160 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.917070e-01 0.160 0 0
Regulation by c-FLIP R-HSA-3371378 6.917070e-01 0.160 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.917070e-01 0.160 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.917070e-01 0.160 0 0
Dimerization of procaspase-8 R-HSA-69416 6.917070e-01 0.160 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.917070e-01 0.160 0 0
Interleukin-9 signaling R-HSA-8985947 6.917070e-01 0.160 0 0
Adrenoceptors R-HSA-390696 6.917070e-01 0.160 0 0
Intestinal absorption R-HSA-8963676 6.917070e-01 0.160 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.917070e-01 0.160 0 0
IRS-mediated signalling R-HSA-112399 6.934852e-01 0.159 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.942674e-01 0.158 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.951654e-01 0.158 0 0
ABC transporter disorders R-HSA-5619084 6.992726e-01 0.155 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.034139e-01 0.153 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.038504e-01 0.153 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.038504e-01 0.153 0 0
HIV elongation arrest and recovery R-HSA-167287 7.038504e-01 0.153 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.038504e-01 0.153 0 0
Insulin receptor recycling R-HSA-77387 7.038504e-01 0.153 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.038504e-01 0.153 0 0
Inflammasomes R-HSA-622312 7.038504e-01 0.153 0 0
PKA activation R-HSA-163615 7.045180e-01 0.152 0 0
PKA activation in glucagon signalling R-HSA-164378 7.045180e-01 0.152 0 0
Elastic fibre formation R-HSA-1566948 7.079913e-01 0.150 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.119371e-01 0.148 0 0
GPER1 signaling R-HSA-9634597 7.138598e-01 0.146 0 0
NGF-stimulated transcription R-HSA-9031628 7.138598e-01 0.146 0 0
ER-Phagosome pathway R-HSA-1236974 7.193100e-01 0.143 0 0
tRNA processing R-HSA-72306 7.201379e-01 0.143 0 0
Regulation of beta-cell development R-HSA-186712 7.203856e-01 0.142 0 0
DARPP-32 events R-HSA-180024 7.220503e-01 0.141 0 0
Glucagon-type ligand receptors R-HSA-420092 7.220503e-01 0.141 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.226379e-01 0.141 0 0
Gap junction degradation R-HSA-190873 7.229944e-01 0.141 0 0
WNT mediated activation of DVL R-HSA-201688 7.229944e-01 0.141 0 0
CASP8 activity is inhibited R-HSA-5218900 7.229944e-01 0.141 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.229944e-01 0.141 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.229944e-01 0.141 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.229944e-01 0.141 0 0
Interleukin-21 signaling R-HSA-9020958 7.229944e-01 0.141 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.229944e-01 0.141 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.229944e-01 0.141 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.229944e-01 0.141 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.229944e-01 0.141 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.229944e-01 0.141 0 0
Interleukin-1 processing R-HSA-448706 7.229944e-01 0.141 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.229944e-01 0.141 0 0
Signaling by ALK R-HSA-201556 7.238290e-01 0.140 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 7.263049e-01 0.139 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.263049e-01 0.139 0 0
Maturation of nucleoprotein R-HSA-9694631 7.263049e-01 0.139 0 0
COPII-mediated vesicle transport R-HSA-204005 7.271197e-01 0.138 0 0
Amyloid fiber formation R-HSA-977225 7.338531e-01 0.134 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.345925e-01 0.134 0 0
Stimuli-sensing channels R-HSA-2672351 7.345925e-01 0.134 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.390189e-01 0.131 0 0
Diseases of Immune System R-HSA-5260271 7.390189e-01 0.131 0 0
Interleukin-2 family signaling R-HSA-451927 7.390189e-01 0.131 0 0
Generation of second messenger molecules R-HSA-202433 7.390189e-01 0.131 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 7.393657e-01 0.131 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.393657e-01 0.131 0 0
PI3K Cascade R-HSA-109704 7.416087e-01 0.130 0 0
Mitochondrial biogenesis R-HSA-1592230 7.417277e-01 0.130 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.424783e-01 0.129 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.456002e-01 0.127 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 7.467149e-01 0.127 0 0
ABC-family proteins mediated transport R-HSA-382556 7.469579e-01 0.127 0 0
Developmental Cell Lineages R-HSA-9734767 7.500564e-01 0.125 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.511082e-01 0.124 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.511082e-01 0.124 0 0
Binding and entry of HIV virion R-HSA-173107 7.511082e-01 0.124 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.511082e-01 0.124 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.511082e-01 0.124 0 0
Maturation of spike protein R-HSA-9683686 7.511082e-01 0.124 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.511082e-01 0.124 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.511082e-01 0.124 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.511082e-01 0.124 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.511082e-01 0.124 0 0
Formation of apoptosome R-HSA-111458 7.511082e-01 0.124 0 0
Meiotic recombination R-HSA-912446 7.547194e-01 0.122 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.553416e-01 0.122 0 0
Selenocysteine synthesis R-HSA-2408557 7.564966e-01 0.121 0 0
Signaling by PDGF R-HSA-186797 7.575755e-01 0.121 0 0
Signaling by Insulin receptor R-HSA-74752 7.605417e-01 0.119 0 0
Ca2+ pathway R-HSA-4086398 7.613448e-01 0.118 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.657840e-01 0.116 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.658030e-01 0.116 0 0
G-protein activation R-HSA-202040 7.658030e-01 0.116 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.658030e-01 0.116 0 0
Signalling to RAS R-HSA-167044 7.658030e-01 0.116 0 0
Acyl chain remodelling of PG R-HSA-1482925 7.658030e-01 0.116 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.673260e-01 0.115 0 0
Viral mRNA Translation R-HSA-192823 7.748202e-01 0.111 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.763703e-01 0.110 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.763703e-01 0.110 0 0
LGI-ADAM interactions R-HSA-5682910 7.763703e-01 0.110 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.763703e-01 0.110 0 0
PECAM1 interactions R-HSA-210990 7.763703e-01 0.110 0 0
Prostanoid ligand receptors R-HSA-391908 7.763703e-01 0.110 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.763703e-01 0.110 0 0
Transport of RCbl within the body R-HSA-9758890 7.763703e-01 0.110 0 0
Insulin receptor signalling cascade R-HSA-74751 7.802731e-01 0.108 0 0
IGF1R signaling cascade R-HSA-2428924 7.802731e-01 0.108 0 0
Activation of GABAB receptors R-HSA-991365 7.807745e-01 0.107 0 0
GABA B receptor activation R-HSA-977444 7.807745e-01 0.107 0 0
Reproduction R-HSA-1474165 7.812157e-01 0.107 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.836273e-01 0.106 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.852226e-01 0.105 0 0
Cardiogenesis R-HSA-9733709 7.861871e-01 0.104 0 0
Cardiac conduction R-HSA-5576891 7.888955e-01 0.103 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.910032e-01 0.102 0 0
Potential therapeutics for SARS R-HSA-9679191 7.910167e-01 0.102 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.990696e-01 0.097 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 7.990696e-01 0.097 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.990696e-01 0.097 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.990696e-01 0.097 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.990696e-01 0.097 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.990696e-01 0.097 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.990696e-01 0.097 0 0
FGFR2 alternative splicing R-HSA-6803529 8.002476e-01 0.097 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.002476e-01 0.097 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.002476e-01 0.097 0 0
LDL clearance R-HSA-8964038 8.002476e-01 0.097 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 8.002476e-01 0.097 0 0
Translation of Structural Proteins R-HSA-9694635 8.019826e-01 0.096 0 0
G alpha (z) signalling events R-HSA-418597 8.021831e-01 0.096 0 0
Proteasome assembly R-HSA-9907900 8.055416e-01 0.094 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.088159e-01 0.092 0 0
Diseases of programmed cell death R-HSA-9645723 8.123224e-01 0.090 0 0
Ub-specific processing proteases R-HSA-5689880 8.130072e-01 0.090 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.133600e-01 0.090 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.157245e-01 0.088 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.157245e-01 0.088 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.157245e-01 0.088 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.157245e-01 0.088 0 0
Carnitine shuttle R-HSA-200425 8.157245e-01 0.088 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.162689e-01 0.088 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.191146e-01 0.087 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.194660e-01 0.086 0 0
Repression of WNT target genes R-HSA-4641265 8.194660e-01 0.086 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.194660e-01 0.086 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.194660e-01 0.086 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.194660e-01 0.086 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.194660e-01 0.086 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.194660e-01 0.086 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.194660e-01 0.086 0 0
Metallothioneins bind metals R-HSA-5661231 8.194660e-01 0.086 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.258127e-01 0.083 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.279829e-01 0.082 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.279829e-01 0.082 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.377931e-01 0.077 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.377931e-01 0.077 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.377931e-01 0.077 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.377931e-01 0.077 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.377931e-01 0.077 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 8.377931e-01 0.077 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.377931e-01 0.077 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.377931e-01 0.077 0 0
Interleukin-6 signaling R-HSA-1059683 8.377931e-01 0.077 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.386989e-01 0.076 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.434913e-01 0.074 0 0
Tight junction interactions R-HSA-420029 8.434913e-01 0.074 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 8.434913e-01 0.074 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.434913e-01 0.074 0 0
RAB geranylgeranylation R-HSA-8873719 8.509426e-01 0.070 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 8.509426e-01 0.070 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.515643e-01 0.070 0 0
Chromosome Maintenance R-HSA-73886 8.525601e-01 0.069 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.527201e-01 0.069 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.542606e-01 0.068 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.542606e-01 0.068 0 0
Hydrolysis of LPC R-HSA-1483115 8.542606e-01 0.068 0 0
cGMP effects R-HSA-418457 8.542606e-01 0.068 0 0
Vitamin B2 (riboflavin) metabolism R-HSA-196843 8.542606e-01 0.068 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.542606e-01 0.068 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.542606e-01 0.068 0 0
Physiological factors R-HSA-5578768 8.542606e-01 0.068 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.542606e-01 0.068 0 0
Ciprofloxacin ADME R-HSA-9793528 8.542606e-01 0.068 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.542606e-01 0.068 0 0
Leishmania phagocytosis R-HSA-9664417 8.552742e-01 0.068 0 0
Parasite infection R-HSA-9664407 8.552742e-01 0.068 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.552742e-01 0.068 0 0
MET activates PTK2 signaling R-HSA-8874081 8.559004e-01 0.068 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.559004e-01 0.068 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.559004e-01 0.068 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.589785e-01 0.066 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.589785e-01 0.066 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.589785e-01 0.066 0 0
Aquaporin-mediated transport R-HSA-445717 8.593931e-01 0.066 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.674041e-01 0.062 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.674041e-01 0.062 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.687341e-01 0.061 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.690572e-01 0.061 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.690572e-01 0.061 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.690572e-01 0.061 0 0
Signaling by Activin R-HSA-1502540 8.690572e-01 0.061 0 0
p38MAPK events R-HSA-171007 8.690572e-01 0.061 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.690572e-01 0.061 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.690572e-01 0.061 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.690572e-01 0.061 0 0
Protein lipoylation R-HSA-9857492 8.690572e-01 0.061 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 8.690572e-01 0.061 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.690572e-01 0.061 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 8.701769e-01 0.060 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.757467e-01 0.058 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 8.771940e-01 0.057 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.778889e-01 0.057 0 0
HIV Transcription Elongation R-HSA-167169 8.778889e-01 0.057 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.778889e-01 0.057 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.802949e-01 0.055 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.817412e-01 0.055 0 0
Killing mechanisms R-HSA-9664420 8.823524e-01 0.054 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.823524e-01 0.054 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.823524e-01 0.054 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.823524e-01 0.054 0 0
Activation of SMO R-HSA-5635838 8.823524e-01 0.054 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.823524e-01 0.054 0 0
Activation of the phototransduction cascade R-HSA-2485179 8.823524e-01 0.054 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.823524e-01 0.054 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.823524e-01 0.054 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.823524e-01 0.054 0 0
Attachment and Entry R-HSA-9678110 8.823524e-01 0.054 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.823524e-01 0.054 0 0
Differentiation of T cells R-HSA-9945266 8.823524e-01 0.054 0 0
Pyruvate metabolism R-HSA-70268 8.864746e-01 0.052 0 0
SLC transporter disorders R-HSA-5619102 8.878405e-01 0.052 0 0
mRNA Capping R-HSA-72086 8.879167e-01 0.052 0 0
Thyroxine biosynthesis R-HSA-209968 8.879167e-01 0.052 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.879167e-01 0.052 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.879167e-01 0.052 0 0
HCMV Late Events R-HSA-9610379 8.915655e-01 0.050 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.942983e-01 0.049 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 8.942983e-01 0.049 0 0
Phase 2 - plateau phase R-HSA-5576893 8.942983e-01 0.049 0 0
Passive transport by Aquaporins R-HSA-432047 8.942983e-01 0.049 0 0
Synthesis of PG R-HSA-1483148 8.942983e-01 0.049 0 0
Response to metal ions R-HSA-5660526 8.942983e-01 0.049 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.942983e-01 0.049 0 0
Viral Infection Pathways R-HSA-9824446 8.943718e-01 0.048 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.945114e-01 0.048 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.945114e-01 0.048 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.951526e-01 0.048 0 0
DAP12 signaling R-HSA-2424491 8.970312e-01 0.047 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.970312e-01 0.047 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.970312e-01 0.047 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.972414e-01 0.047 0 0
Hemostasis R-HSA-109582 9.019571e-01 0.045 0 0
Kidney development R-HSA-9830369 9.020519e-01 0.045 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.043823e-01 0.044 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.050318e-01 0.043 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 9.050318e-01 0.043 0 0
Choline catabolism R-HSA-6798163 9.050318e-01 0.043 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 9.053777e-01 0.043 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.054512e-01 0.043 0 0
Cargo concentration in the ER R-HSA-5694530 9.054512e-01 0.043 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.054512e-01 0.043 0 0
Defective pyroptosis R-HSA-9710421 9.090717e-01 0.041 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.101631e-01 0.041 0 0
Immune System R-HSA-168256 9.120621e-01 0.040 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.129040e-01 0.040 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.132236e-01 0.039 0 0
Apoptotic factor-mediated response R-HSA-111471 9.146760e-01 0.039 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.146760e-01 0.039 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.146760e-01 0.039 0 0
Tie2 Signaling R-HSA-210993 9.146760e-01 0.039 0 0
Surfactant metabolism R-HSA-5683826 9.156461e-01 0.038 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.181716e-01 0.037 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.212708e-01 0.036 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.233413e-01 0.035 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.233413e-01 0.035 0 0
Specification of the neural plate border R-HSA-9834899 9.233413e-01 0.035 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.233413e-01 0.035 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.233413e-01 0.035 0 0
Diseases of hemostasis R-HSA-9671793 9.233413e-01 0.035 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.233413e-01 0.035 0 0
STING mediated induction of host immune responses R-HSA-1834941 9.233413e-01 0.035 0 0
PPARA activates gene expression R-HSA-1989781 9.263308e-01 0.033 0 0
Extension of Telomeres R-HSA-180786 9.268398e-01 0.033 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.268398e-01 0.033 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.268398e-01 0.033 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.270020e-01 0.033 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.270020e-01 0.033 0 0
Heme degradation R-HSA-189483 9.270020e-01 0.033 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.274574e-01 0.033 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.274574e-01 0.033 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.275114e-01 0.033 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.275114e-01 0.033 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.275114e-01 0.033 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.282752e-01 0.032 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.311271e-01 0.031 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.311271e-01 0.031 0 0
Signaling by NODAL R-HSA-1181150 9.311271e-01 0.031 0 0
Pregnenolone biosynthesis R-HSA-196108 9.311271e-01 0.031 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.311271e-01 0.031 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.311271e-01 0.031 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.311271e-01 0.031 0 0
Signal transduction by L1 R-HSA-445144 9.311271e-01 0.031 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.311271e-01 0.031 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.311373e-01 0.031 0 0
GABA receptor activation R-HSA-977443 9.317453e-01 0.031 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.326804e-01 0.030 0 0
Synthesis of PC R-HSA-1483191 9.328509e-01 0.030 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.329754e-01 0.030 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.330902e-01 0.030 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.330902e-01 0.030 0 0
eNOS activation R-HSA-203615 9.330902e-01 0.030 0 0
Platelet degranulation R-HSA-114608 9.367445e-01 0.028 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.381225e-01 0.028 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.381225e-01 0.028 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.381225e-01 0.028 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.381225e-01 0.028 0 0
Phenylalanine metabolism R-HSA-8964208 9.381225e-01 0.028 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.381225e-01 0.028 0 0
Potassium Channels R-HSA-1296071 9.384286e-01 0.028 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.386951e-01 0.027 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.386951e-01 0.027 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.392261e-01 0.027 0 0
Mitochondrial protein import R-HSA-1268020 9.406731e-01 0.027 0 0
GPVI-mediated activation cascade R-HSA-114604 9.438523e-01 0.025 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.438523e-01 0.025 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.444077e-01 0.025 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.444077e-01 0.025 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.444077e-01 0.025 0 0
Attachment and Entry R-HSA-9694614 9.444077e-01 0.025 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.447258e-01 0.025 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.467677e-01 0.024 0 0
Voltage gated Potassium channels R-HSA-1296072 9.485947e-01 0.023 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.485947e-01 0.023 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.500549e-01 0.022 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.500549e-01 0.022 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.500549e-01 0.022 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.500549e-01 0.022 0 0
The phototransduction cascade R-HSA-2514856 9.507757e-01 0.022 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.517354e-01 0.021 0 0
Integrin cell surface interactions R-HSA-216083 9.517354e-01 0.021 0 0
Base Excision Repair R-HSA-73884 9.525828e-01 0.021 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.529534e-01 0.021 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.551287e-01 0.020 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.551287e-01 0.020 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.551287e-01 0.020 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.551287e-01 0.020 0 0
Interleukin-20 family signaling R-HSA-8854691 9.551287e-01 0.020 0 0
Pentose phosphate pathway R-HSA-71336 9.569573e-01 0.019 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.569573e-01 0.019 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.569573e-01 0.019 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.569573e-01 0.019 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.585261e-01 0.018 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.596873e-01 0.018 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.596873e-01 0.018 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.596873e-01 0.018 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.596873e-01 0.018 0 0
Interleukin-6 family signaling R-HSA-6783589 9.596873e-01 0.018 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.606336e-01 0.017 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.608359e-01 0.017 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.625848e-01 0.017 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.625848e-01 0.017 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.625848e-01 0.017 0 0
Leishmania infection R-HSA-9658195 9.633582e-01 0.016 0 0
Parasitic Infection Pathways R-HSA-9824443 9.633582e-01 0.016 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.637831e-01 0.016 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.637831e-01 0.016 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.637831e-01 0.016 0 0
Hyaluronan degradation R-HSA-2160916 9.637831e-01 0.016 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.637831e-01 0.016 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.637831e-01 0.016 0 0
Formation of the nephric duct R-HSA-9830364 9.637831e-01 0.016 0 0
Retinoid cycle disease events R-HSA-2453864 9.637831e-01 0.016 0 0
Diseases associated with visual transduction R-HSA-2474795 9.637831e-01 0.016 0 0
Diseases of the neuronal system R-HSA-9675143 9.637831e-01 0.016 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.637831e-01 0.016 0 0
Laminin interactions R-HSA-3000157 9.637831e-01 0.016 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.640075e-01 0.016 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.671025e-01 0.015 0 0
Heme biosynthesis R-HSA-189451 9.671025e-01 0.015 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.674629e-01 0.014 0 0
TRP channels R-HSA-3295583 9.674629e-01 0.014 0 0
Sphingolipid catabolism R-HSA-9845614 9.674629e-01 0.014 0 0
Abacavir ADME R-HSA-2161522 9.674629e-01 0.014 0 0
Platelet homeostasis R-HSA-418346 9.681513e-01 0.014 0 0
Synthesis of PA R-HSA-1483166 9.694780e-01 0.013 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.699404e-01 0.013 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.707691e-01 0.013 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.707691e-01 0.013 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.707691e-01 0.013 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.707691e-01 0.013 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.707691e-01 0.013 0 0
Signaling by BMP R-HSA-201451 9.707691e-01 0.013 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.728106e-01 0.012 0 0
Telomere Maintenance R-HSA-157579 9.734592e-01 0.012 0 0
Telomere Extension By Telomerase R-HSA-171319 9.737395e-01 0.012 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.737395e-01 0.012 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.737395e-01 0.012 0 0
Pyroptosis R-HSA-5620971 9.737395e-01 0.012 0 0
DAP12 interactions R-HSA-2172127 9.749244e-01 0.011 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.749244e-01 0.011 0 0
Amine ligand-binding receptors R-HSA-375280 9.749244e-01 0.011 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.752830e-01 0.011 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.764082e-01 0.010 0 0
Platelet calcium homeostasis R-HSA-418360 9.764082e-01 0.010 0 0
Endogenous sterols R-HSA-211976 9.779645e-01 0.010 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.788058e-01 0.009 0 0
Neurotransmitter clearance R-HSA-112311 9.788058e-01 0.009 0 0
Phospholipid metabolism R-HSA-1483257 9.793270e-01 0.009 0 0
Formation of the cornified envelope R-HSA-6809371 9.797019e-01 0.009 0 0
Neurotransmitter release cycle R-HSA-112310 9.803510e-01 0.009 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.809334e-01 0.008 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.809599e-01 0.008 0 0
Complex I biogenesis R-HSA-6799198 9.813133e-01 0.008 0 0
Cholesterol biosynthesis R-HSA-191273 9.817521e-01 0.008 0 0
Gluconeogenesis R-HSA-70263 9.826062e-01 0.008 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.841361e-01 0.007 0 0
rRNA processing R-HSA-72312 9.842373e-01 0.007 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.846338e-01 0.007 0 0
Recycling of bile acids and salts R-HSA-159418 9.846338e-01 0.007 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.852680e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.854399e-01 0.006 0 0
Selenoamino acid metabolism R-HSA-2408522 9.860093e-01 0.006 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.861958e-01 0.006 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.866096e-01 0.006 0 0
Hyaluronan metabolism R-HSA-2142845 9.875992e-01 0.005 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.875992e-01 0.005 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.875992e-01 0.005 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.875992e-01 0.005 0 0
Transcription of the HIV genome R-HSA-167172 9.876888e-01 0.005 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.879812e-01 0.005 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.888599e-01 0.005 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.893659e-01 0.005 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.896017e-01 0.005 0 0
Glycosphingolipid transport R-HSA-9845576 9.899925e-01 0.004 0 0
Triglyceride catabolism R-HSA-163560 9.899925e-01 0.004 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.899925e-01 0.004 0 0
Metabolism of porphyrins R-HSA-189445 9.904474e-01 0.004 0 0
Paracetamol ADME R-HSA-9753281 9.909119e-01 0.004 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.910101e-01 0.004 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.910101e-01 0.004 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.910101e-01 0.004 0 0
Metabolism of folate and pterines R-HSA-196757 9.910101e-01 0.004 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.917237e-01 0.004 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.919242e-01 0.004 0 0
Purine salvage R-HSA-74217 9.919242e-01 0.004 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.934153e-01 0.003 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.934832e-01 0.003 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.934832e-01 0.003 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.934832e-01 0.003 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.934832e-01 0.003 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.939233e-01 0.003 0 0
Maturation of spike protein R-HSA-9694548 9.941460e-01 0.003 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.941460e-01 0.003 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.941460e-01 0.003 0 0
G alpha (q) signalling events R-HSA-416476 9.942269e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.943184e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.943184e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.943184e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.946352e-01 0.002 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.947414e-01 0.002 0 0
HIV Transcription Initiation R-HSA-167161 9.947414e-01 0.002 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.947414e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.947414e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.947607e-01 0.002 0 0
Innate Immune System R-HSA-168249 9.950680e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.951959e-01 0.002 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.952762e-01 0.002 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.952762e-01 0.002 0 0
Depyrimidination R-HSA-73928 9.952762e-01 0.002 0 0
Mitochondrial protein degradation R-HSA-9837999 9.956031e-01 0.002 0 0
Collagen formation R-HSA-1474290 9.956031e-01 0.002 0 0
Digestion and absorption R-HSA-8963743 9.957229e-01 0.002 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.957567e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.961884e-01 0.002 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.965761e-01 0.001 0 0
The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 9.965761e-01 0.001 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.968960e-01 0.001 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.972065e-01 0.001 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.974352e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.977710e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.977992e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.979606e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.979978e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.980079e-01 0.001 0 0
Translation R-HSA-72766 9.981570e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.981905e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.982016e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.983689e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.984805e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.985490e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.985779e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.985779e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.986450e-01 0.001 0 0
Glucuronidation R-HSA-156588 9.986967e-01 0.001 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.986967e-01 0.001 0 0
Digestion R-HSA-8935690 9.989485e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.990556e-01 0.000 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.991517e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.991713e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.991857e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.992381e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.993797e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.993854e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.993854e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.994731e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.995291e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.995547e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.996106e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.996774e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.996774e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.997102e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.997901e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.997901e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997901e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.997936e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998080e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998115e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998900e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.998946e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999112e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999284e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999455e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999471e-01 0.000 0 0
Disease R-HSA-1643685 9.999581e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999615e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999765e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999784e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999800e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999802e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999820e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999843e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999856e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999864e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999872e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999884e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999888e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999897e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999917e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999936e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999951e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999959e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999977e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999978e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999982e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999989e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999992e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999992e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999995e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999997e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999998e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999998e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways