PKR

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
P04637 S392 SIGNOR|iPTMNet|EPSD|PSP TP53 P53 KKGQstsRHKKLMFKtEGPDsD___________________
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05198 S49 GPS6|ELM|iPTMNet|EPSD|PSP EIF2S1 EIF2A EMGAYVSLLEYNNIEGMILLsELsRRRIRSINKLIRIGRNE
P05198 S52 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF2S1 EIF2A AYVSLLEYNNIEGMILLsELsRRRIRSINKLIRIGRNECVV
P06493 Y4 SIGNOR|EPSD|PSP CDK1 CDC2 CDC28A CDKN1 P34CDC2 _________________MEDyTKIEKIGEGtyGVVyKGRHK
P14618 S37 Sugiyama PKM OIP3 PK2 PK3 PKM2 QLHAAMADTFLEHMCRLDIDsPPItARNtGIICtIGPAsRs
P19525 S242 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF2AK2 PKR PRKR LNSSSLLMNGLRNNQRKAKRsLAPRFDLPDMKEtKYtVDKR
P19525 S418 Sugiyama EIF2AK2 PKR PRKR ITKGVDYIHSKKLIHRDLKPsNIFLVDtKQVKIGDFGLVts
P19525 S456 Sugiyama EIF2AK2 PKR PRKR VtsLKNDGKRtRSKGtLRyMsPEQIssQDYGKEVDLYALGL
P19525 S461 Sugiyama EIF2AK2 PKR PRKR NDGKRtRSKGtLRyMsPEQIssQDYGKEVDLYALGLILAEL
P19525 S462 Sugiyama EIF2AK2 PKR PRKR DGKRtRSKGtLRyMsPEQIssQDYGKEVDLYALGLILAELL
P19525 S6 PSP EIF2AK2 PKR PRKR _______________MAGDLsAGFFMEELNTYRQKQGVVLK
P19525 S83 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF2AK2 PKR PRKR AKNAAAKLAVEILNKEKKAVsPLLLtttNssEGLsMGNyIG
P19525 T255 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF2AK2 PKR PRKR NQRKAKRsLAPRFDLPDMKEtKYtVDKRFGMDFKEIELIGS
P19525 T258 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF2AK2 PKR PRKR KAKRsLAPRFDLPDMKEtKYtVDKRFGMDFKEIELIGSGGF
P19525 T425 Sugiyama EIF2AK2 PKR PRKR IHSKKLIHRDLKPsNIFLVDtKQVKIGDFGLVtsLKNDGKR
P19525 T446 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF2AK2 PKR PRKR KQVKIGDFGLVtsLKNDGKRtRSKGtLRyMsPEQIssQDYG
P19525 T451 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP|Sugiyama EIF2AK2 PKR PRKR GDFGLVtsLKNDGKRtRSKGtLRyMsPEQIssQDYGKEVDL
P19525 T529 Sugiyama EIF2AK2 PKR PRKR KKEKTLLQKLLSKKPEDRPNtSEILRTLTVWKKsPEKNERH
P19525 T88 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF2AK2 PKR PRKR AKLAVEILNKEKKAVsPLLLtttNssEGLsMGNyIGLINRI
P19525 T89 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF2AK2 PKR PRKR KLAVEILNKEKKAVsPLLLtttNssEGLsMGNyIGLINRIA
P19525 T90 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP EIF2AK2 PKR PRKR LAVEILNKEKKAVsPLLLtttNssEGLsMGNyIGLINRIAQ
P19525 Y101 SIGNOR|iPTMNet|EPSD|PSP EIF2AK2 PKR PRKR AVsPLLLtttNssEGLsMGNyIGLINRIAQKKRLTVNYEQC
P19525 Y162 SIGNOR|iPTMNet|EPSD|PSP EIF2AK2 PKR PRKR YSIGTGSTKQEAKQLAAKLAyLQILSEETSVKSDYLSSGSF
P19525 Y293 SIGNOR|iPTMNet|EPSD|PSP EIF2AK2 PKR PRKR IGSGGFGQVFKAKHRIDGKTyVIKRVKYNNEKAEREVKALA
P19525 Y454 Sugiyama EIF2AK2 PKR PRKR GLVtsLKNDGKRtRSKGtLRyMsPEQIssQDYGKEVDLYAL
P25963 S32 SIGNOR|iPTMNet|EPSD NFKBIA IKBA MAD3 NFKBI AMEGPRDGLKKERLLDDRHDsGLDsMKDEEyEQMVKELQEI
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P54105 S102 Sugiyama CLNS1A CLCI ICLN VNAKFEEEsKEPVADEEEEDsDDDVEPITEFRFVPSDKSAL
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
Q13263 S473 PSP TRIM28 KAP1 RNF96 TIF1B sGDDPyssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERL
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15172 S28 SIGNOR|iPTMNet|EPSD|PSP PPP2R5A AGAASAAISASEKVDGFTRKsVRKAQRQKRsQGssQFRsQG
Q15637 S80 Sugiyama SF1 ZFM1 ZNF162 DLTRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFR
Q15637 S82 Sugiyama SF1 ZFM1 ZNF162 TRKLRtGDLGIPPNPEDRsPsPEPIyNsEGKRLNTREFRTR
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q6PCE3 S175 Sugiyama PGM2L1 BM32A PFVPYAVQKLKAVAGVMItAsHNRKEDNGYKVYWETGAQIT
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q8IWX8 S817 Sugiyama CHERP DAN26 SCAF6 QSRSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDS
Q8IWX8 T819 Sugiyama CHERP DAN26 SCAF6 RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q96EZ8 S282 Sugiyama MCRS1 INO80Q MSP58 YLLEDQTVQPLPKGDQVLNFsDAEDLIDDSKLKDMRDEVLE
Q96G46 T273 Sugiyama DUS3L GAPRQENCGAQQVPAGPGtstPPssPVRtCGPLtDEDVVRL
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9H3R0 S918 SIGNOR|PSP KDM4C GASC1 JHDM3C JMJD2C KIAA0780 RVMAVTSQTFYEVMFDDGSFsRDTFPEDIVSRDCLKLGPPA
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Axon guidance R-HSA-422475 2.599909e-11 10.585 0 0
Nervous system development R-HSA-9675108 3.609003e-10 9.443 0 0
Signal Transduction R-HSA-162582 9.777338e-10 9.010 0 0
Post NMDA receptor activation events R-HSA-438064 5.114626e-09 8.291 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.508446e-08 7.070 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.556436e-08 7.068 0 0
Apoptotic execution phase R-HSA-75153 1.270319e-07 6.896 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.905525e-07 6.309 0 0
Recycling pathway of L1 R-HSA-437239 9.165134e-07 6.038 0 0
EPH-Ephrin signaling R-HSA-2682334 1.213174e-06 5.916 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.367893e-06 5.864 0 0
mRNA 3'-end processing R-HSA-72187 2.481708e-06 5.605 0 0
L1CAM interactions R-HSA-373760 3.102827e-06 5.508 0 0
mRNA Splicing R-HSA-72172 3.574619e-06 5.447 0 0
Semaphorin interactions R-HSA-373755 3.611859e-06 5.442 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.785962e-06 5.422 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.334007e-06 5.363 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.138349e-06 5.289 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.541638e-06 5.256 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.877624e-06 5.163 0 0
RAF activation R-HSA-5673000 8.161455e-06 5.088 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.938043e-06 5.100 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.517060e-06 5.021 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.003412e-05 4.999 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.178206e-05 4.929 0 0
Signaling by RAS mutants R-HSA-6802949 2.045235e-05 4.689 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.045235e-05 4.689 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.045235e-05 4.689 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.045235e-05 4.689 0 0
MAPK family signaling cascades R-HSA-5683057 1.963053e-05 4.707 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.101450e-05 4.677 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.172446e-05 4.663 0 0
Cell Cycle R-HSA-1640170 2.535090e-05 4.596 0 0
Signaling by VEGF R-HSA-194138 2.982798e-05 4.525 0 0
Signaling by ERBB2 R-HSA-1227986 4.360155e-05 4.360 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.272778e-05 4.278 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 6.540869e-05 4.184 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.354997e-05 4.133 0 0
Cell Cycle, Mitotic R-HSA-69278 7.944266e-05 4.100 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.079882e-05 4.042 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.113193e-04 3.953 0 0
Muscle contraction R-HSA-397014 1.168453e-04 3.932 0 0
GPER1 signaling R-HSA-9634597 1.310144e-04 3.883 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.433357e-04 3.844 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.620120e-04 3.790 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.620120e-04 3.790 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.677674e-04 3.775 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.641193e-04 3.785 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.698274e-04 3.770 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.935771e-04 3.713 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.920185e-04 3.717 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.986603e-04 3.702 0 0
Activation of RAS in B cells R-HSA-1169092 2.387791e-04 3.622 0 0
ESR-mediated signaling R-HSA-8939211 2.410377e-04 3.618 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.706247e-04 3.568 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.766538e-04 3.558 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.800224e-04 3.553 0 0
Oncogene Induced Senescence R-HSA-2559585 2.812747e-04 3.551 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.081691e-04 3.511 0 0
Apoptosis R-HSA-109581 3.045295e-04 3.516 0 0
Metabolism of RNA R-HSA-8953854 3.878678e-04 3.411 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.163765e-04 3.381 0 0
Ion homeostasis R-HSA-5578775 4.022376e-04 3.396 0 0
Neuronal System R-HSA-112316 4.179473e-04 3.379 0 0
G-protein mediated events R-HSA-112040 4.207265e-04 3.376 0 0
Cellular Senescence R-HSA-2559583 4.532036e-04 3.344 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.362171e-04 3.360 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.812196e-04 3.318 0 0
Transmission across Chemical Synapses R-HSA-112315 5.241929e-04 3.281 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.351193e-04 3.197 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 6.619100e-04 3.179 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.073755e-04 3.150 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.748826e-04 3.171 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.050293e-04 3.094 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.160095e-04 3.088 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.564807e-04 3.067 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.564807e-04 3.067 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.564807e-04 3.067 0 0
Mitotic Anaphase R-HSA-68882 8.103548e-04 3.091 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 8.575257e-04 3.067 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 9.597734e-04 3.018 0 0
Long-term potentiation R-HSA-9620244 9.715369e-04 3.013 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 9.715369e-04 3.013 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.307808e-04 3.031 0 0
Signaling by PTK6 R-HSA-8848021 9.307808e-04 3.031 0 0
M Phase R-HSA-68886 1.017184e-03 2.993 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.130888e-03 2.947 0 0
Ephrin signaling R-HSA-3928664 1.073582e-03 2.969 0 0
Signaling by FGFR4 R-HSA-5654743 1.100259e-03 2.959 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.073582e-03 2.969 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.255866e-03 2.901 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.330578e-03 2.876 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.347605e-03 2.870 0 0
G alpha (12/13) signalling events R-HSA-416482 1.347605e-03 2.870 0 0
Signaling by EGFR R-HSA-177929 1.468280e-03 2.833 0 0
Signaling by FGFR3 R-HSA-5654741 1.428752e-03 2.845 0 0
Signaling by FGFR1 R-HSA-5654736 1.468280e-03 2.833 0 0
NRAGE signals death through JNK R-HSA-193648 1.468280e-03 2.833 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.385154e-03 2.859 0 0
SOS-mediated signalling R-HSA-112412 1.611272e-03 2.793 0 0
PKR-mediated signaling R-HSA-9833482 1.628201e-03 2.788 1 1
MECP2 regulates transcription factors R-HSA-9022707 1.611272e-03 2.793 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.614776e-03 2.792 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.614776e-03 2.792 0 0
Developmental Biology R-HSA-1266738 1.512939e-03 2.820 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.628201e-03 2.788 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.632058e-03 2.787 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.637804e-03 2.786 0 0
Regulation of CDH1 Function R-HSA-9764561 1.642697e-03 2.784 0 0
Protein folding R-HSA-391251 1.914807e-03 2.718 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.924907e-03 2.716 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.982788e-03 2.703 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.982788e-03 2.703 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.249522e-03 2.648 0 0
Mitotic Prometaphase R-HSA-68877 2.264458e-03 2.645 0 0
Gap junction trafficking and regulation R-HSA-157858 2.321138e-03 2.634 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.347033e-03 2.629 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.387689e-03 2.622 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.387689e-03 2.622 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.387689e-03 2.622 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.387689e-03 2.622 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 2.670018e-03 2.573 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.670018e-03 2.573 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.783711e-03 2.555 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.661200e-03 2.575 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.614804e-03 2.583 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.577435e-03 2.589 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.851811e-03 2.545 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.885212e-03 2.540 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.013085e-03 2.521 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.095116e-03 2.509 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.726692e-03 2.429 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.978423e-03 2.400 0 0
Striated Muscle Contraction R-HSA-390522 3.987524e-03 2.399 0 0
Cell junction organization R-HSA-446728 4.023073e-03 2.395 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 4.482984e-03 2.348 0 0
Diseases of Telomere Maintenance R-HSA-9673013 4.482984e-03 2.348 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 4.482984e-03 2.348 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 4.482984e-03 2.348 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 4.482984e-03 2.348 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.069078e-03 2.391 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.103562e-03 2.387 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.182445e-03 2.379 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.103562e-03 2.387 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.103562e-03 2.387 0 0
Programmed Cell Death R-HSA-5357801 4.430707e-03 2.354 0 0
Separation of Sister Chromatids R-HSA-2467813 4.558244e-03 2.341 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.607500e-03 2.337 0 0
Gap junction trafficking R-HSA-190828 4.631195e-03 2.334 0 0
Signaling by FGFR2 R-HSA-5654738 4.749791e-03 2.323 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.897806e-03 2.310 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.173228e-03 2.286 0 0
Opioid Signalling R-HSA-111885 5.178358e-03 2.286 0 0
Signaling by EGFR in Cancer R-HSA-1643713 5.404676e-03 2.267 0 0
Calmodulin induced events R-HSA-111933 5.847375e-03 2.233 0 0
CaM pathway R-HSA-111997 5.847375e-03 2.233 0 0
Cell-Cell communication R-HSA-1500931 5.345214e-03 2.272 0 0
Death Receptor Signaling R-HSA-73887 5.764658e-03 2.239 0 0
Tie2 Signaling R-HSA-210993 5.926323e-03 2.227 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.401388e-03 2.194 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.591974e-03 2.181 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.740831e-03 2.171 0 0
Signaling by AXIN mutants R-HSA-4839735 6.740831e-03 2.171 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.740831e-03 2.171 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 6.792594e-03 2.168 0 0
Signaling by ALK in cancer R-HSA-9700206 6.792594e-03 2.168 0 0
Kinesins R-HSA-983189 7.142063e-03 2.146 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.401444e-03 2.076 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.401444e-03 2.076 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.401444e-03 2.076 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.401444e-03 2.076 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.401444e-03 2.076 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.071984e-03 2.093 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.401444e-03 2.076 0 0
MET activates RAS signaling R-HSA-8851805 8.401444e-03 2.076 0 0
Signaling by LTK R-HSA-9842663 8.401444e-03 2.076 0 0
Intracellular signaling by second messengers R-HSA-9006925 7.769947e-03 2.110 0 0
Adherens junctions interactions R-HSA-418990 8.093679e-03 2.092 0 0
Signaling by FGFR R-HSA-190236 8.579512e-03 2.067 0 0
DAP12 signaling R-HSA-2424491 9.325872e-03 2.030 0 0
Interleukin-12 signaling R-HSA-9020591 9.506283e-03 2.022 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.723236e-03 2.012 0 0
Signalling to RAS R-HSA-167044 9.723236e-03 2.012 0 0
Cellular responses to stress R-HSA-2262752 9.986724e-03 2.001 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.024350e-02 1.990 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 1.024350e-02 1.990 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.045269e-02 1.981 1 0
Downstream signal transduction R-HSA-186763 1.055930e-02 1.976 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 1.129130e-02 1.947 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.129130e-02 1.947 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.129130e-02 1.947 0 0
MAP2K and MAPK activation R-HSA-5674135 1.141015e-02 1.943 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.258443e-02 1.900 0 0
Ca-dependent events R-HSA-111996 1.261750e-02 1.899 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.491590e-02 1.826 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.491590e-02 1.826 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.491590e-02 1.826 0 0
p38MAPK events R-HSA-171007 1.491590e-02 1.826 0 0
Erythropoietin activates RAS R-HSA-9027284 1.491590e-02 1.826 0 0
Signaling by SCF-KIT R-HSA-1433557 1.391414e-02 1.857 0 0
G2/M Transition R-HSA-69275 1.411029e-02 1.850 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.491590e-02 1.826 0 0
Cellular responses to stimuli R-HSA-8953897 1.429041e-02 1.845 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.336514e-02 1.874 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.389575e-02 1.857 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.492624e-02 1.826 0 0
Cardiac conduction R-HSA-5576891 1.535116e-02 1.814 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.539383e-02 1.813 0 0
Ion channel transport R-HSA-983712 1.606889e-02 1.794 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.614798e-02 1.792 0 0
Cell-cell junction organization R-HSA-421270 1.634826e-02 1.787 0 0
Regulation of TP53 Activity R-HSA-5633007 1.638090e-02 1.786 0 0
Mitotic Prophase R-HSA-68875 1.665116e-02 1.779 0 0
Signal amplification R-HSA-392518 1.665448e-02 1.778 0 0
Gap junction assembly R-HSA-190861 1.665448e-02 1.778 0 0
DAG and IP3 signaling R-HSA-1489509 1.678849e-02 1.775 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.681541e-02 1.774 0 0
Regulation of TP53 Expression R-HSA-6804754 1.681541e-02 1.774 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.681541e-02 1.774 0 0
Diseases of cellular response to stress R-HSA-9675132 1.681541e-02 1.774 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.681541e-02 1.774 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.681541e-02 1.774 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.681541e-02 1.774 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.681541e-02 1.774 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.681541e-02 1.774 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.681541e-02 1.774 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.681541e-02 1.774 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.681541e-02 1.774 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.681541e-02 1.774 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.681541e-02 1.774 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.681541e-02 1.774 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.697768e-02 1.770 0 0
Stimuli-sensing channels R-HSA-2672351 1.697768e-02 1.770 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 1.700676e-02 1.769 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.064629e-02 1.685 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.919655e-02 1.717 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.919655e-02 1.717 0 0
MHC class II antigen presentation R-HSA-2132295 1.952126e-02 1.709 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.814521e-02 1.741 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.064629e-02 1.685 0 0
Signalling to ERKs R-HSA-187687 1.849165e-02 1.733 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.074613e-02 1.683 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.165938e-02 1.664 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.172454e-02 1.663 0 0
Interleukin-12 family signaling R-HSA-447115 2.178425e-02 1.662 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.182114e-02 1.661 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.182114e-02 1.661 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.182114e-02 1.661 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 2.182114e-02 1.661 0 0
PLC beta mediated events R-HSA-112043 2.200394e-02 1.657 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.293345e-02 1.640 0 0
Hedgehog 'off' state R-HSA-5610787 2.293487e-02 1.640 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.316907e-02 1.635 0 0
Selective autophagy R-HSA-9663891 2.316907e-02 1.635 0 0
RNA Polymerase II Transcription R-HSA-73857 2.346182e-02 1.630 0 0
Signaling by Hippo R-HSA-2028269 2.395345e-02 1.621 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 2.437257e-02 1.613 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.480660e-02 1.605 1 0
Signaling by Nuclear Receptors R-HSA-9006931 2.553059e-02 1.593 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.575869e-02 1.589 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.624089e-02 1.581 0 0
Leishmania infection R-HSA-9658195 2.636121e-02 1.579 0 0
Parasitic Infection Pathways R-HSA-9824443 2.636121e-02 1.579 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.677839e-02 1.572 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.721730e-02 1.565 0 0
IGF1R signaling cascade R-HSA-2428924 2.734161e-02 1.563 0 0
Polo-like kinase mediated events R-HSA-156711 2.756343e-02 1.560 0 0
Signaling by ROBO receptors R-HSA-376176 2.814103e-02 1.551 0 0
Signaling by Interleukins R-HSA-449147 2.822641e-02 1.549 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.930426e-02 1.533 0 0
Sensory processing of sound R-HSA-9659379 2.966781e-02 1.528 0 0
Aggrephagy R-HSA-9646399 2.976069e-02 1.526 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.026988e-02 1.519 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.026988e-02 1.519 0 0
TNFR1-mediated ceramide production R-HSA-5626978 3.549796e-02 1.450 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.549796e-02 1.450 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 3.549796e-02 1.450 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.228506e-02 1.491 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.228506e-02 1.491 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.228506e-02 1.491 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.228506e-02 1.491 0 0
G alpha (z) signalling events R-HSA-418597 3.755032e-02 1.425 0 0
Specification of the neural plate border R-HSA-9834899 3.148066e-02 1.502 0 0
Activation of GABAB receptors R-HSA-991365 3.830717e-02 1.417 0 0
GABA B receptor activation R-HSA-977444 3.830717e-02 1.417 0 0
Signaling by APC mutants R-HSA-4839744 3.228506e-02 1.491 0 0
Gene expression (Transcription) R-HSA-74160 3.416431e-02 1.466 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.184158e-02 1.497 0 0
Rap1 signalling R-HSA-392517 3.148066e-02 1.502 0 0
Signal transduction by L1 R-HSA-445144 3.570822e-02 1.447 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.352675e-02 1.475 0 0
Trafficking of AMPA receptors R-HSA-399719 3.699324e-02 1.432 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.148066e-02 1.502 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.833511e-02 1.416 0 0
Activation of RAC1 R-HSA-428540 3.833511e-02 1.416 0 0
Signaling by AMER1 mutants R-HSA-4839748 3.833511e-02 1.416 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.024796e-02 1.395 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 4.024796e-02 1.395 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.044762e-02 1.393 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.057565e-02 1.392 0 0
Signaling by WNT in cancer R-HSA-4791275 4.067177e-02 1.391 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.311967e-02 1.365 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.313271e-02 1.365 0 0
Integrin signaling R-HSA-354192 4.456421e-02 1.351 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.456421e-02 1.351 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.456421e-02 1.351 0 0
GPCR downstream signalling R-HSA-388396 4.469255e-02 1.350 0 0
Netrin-1 signaling R-HSA-373752 4.479129e-02 1.349 0 0
DAP12 interactions R-HSA-2172127 4.479129e-02 1.349 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.491910e-02 1.348 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.491910e-02 1.348 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.503631e-02 1.346 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.503631e-02 1.346 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.503631e-02 1.346 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.510044e-02 1.346 0 0
Signaling by PDGFR in disease R-HSA-9671555 4.510044e-02 1.346 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.681038e-02 1.330 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 4.681038e-02 1.330 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 4.681038e-02 1.330 0 0
NrCAM interactions R-HSA-447038 4.681038e-02 1.330 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 4.775841e-02 1.321 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 4.775841e-02 1.321 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 4.775841e-02 1.321 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 4.775841e-02 1.321 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 4.775841e-02 1.321 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 4.775841e-02 1.321 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.970425e-02 1.304 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.026510e-02 1.299 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 5.026510e-02 1.299 0 0
Signaling by KIT in disease R-HSA-9669938 5.026510e-02 1.299 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.192058e-02 1.285 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.202465e-02 1.284 0 0
Signaling by GPCR R-HSA-372790 5.288689e-02 1.277 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.299559e-02 1.276 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.924212e-02 1.227 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.924212e-02 1.227 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.924212e-02 1.227 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.773862e-02 1.169 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.152303e-02 1.211 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.573001e-02 1.254 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.970355e-02 1.224 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.924212e-02 1.227 0 0
CREB phosphorylation R-HSA-199920 7.266077e-02 1.139 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.895662e-02 1.229 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 6.649516e-02 1.177 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 6.649516e-02 1.177 0 0
Cell Cycle Checkpoints R-HSA-69620 5.980676e-02 1.223 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.266077e-02 1.139 0 0
Intraflagellar transport R-HSA-5620924 5.970355e-02 1.224 0 0
RET signaling R-HSA-8853659 6.229159e-02 1.206 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.818539e-02 1.235 0 0
Signaling by NTRKs R-HSA-166520 6.888481e-02 1.162 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.152303e-02 1.211 0 0
Ion transport by P-type ATPases R-HSA-936837 6.666596e-02 1.176 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.380566e-02 1.195 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.857816e-02 1.232 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.753557e-02 1.240 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.753557e-02 1.240 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.924212e-02 1.227 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.773862e-02 1.169 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 6.773862e-02 1.169 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 6.773862e-02 1.169 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.963684e-02 1.224 0 0
TRP channels R-HSA-3295583 7.399586e-02 1.131 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.465365e-02 1.127 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.499888e-02 1.125 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.499888e-02 1.125 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.631116e-02 1.117 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.660205e-02 1.116 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.783430e-02 1.109 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.067565e-02 1.093 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.067565e-02 1.093 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.067565e-02 1.093 0 0
Smooth Muscle Contraction R-HSA-445355 8.203480e-02 1.086 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.301712e-02 1.081 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 8.694396e-02 1.061 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 8.694396e-02 1.061 0 0
Netrin mediated repulsion signals R-HSA-418886 8.694396e-02 1.061 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 8.694396e-02 1.061 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 8.694396e-02 1.061 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.764286e-02 1.057 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 8.926891e-02 1.049 0 0
Parasite infection R-HSA-9664407 8.936335e-02 1.049 0 0
Leishmania phagocytosis R-HSA-9664417 8.936335e-02 1.049 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.936335e-02 1.049 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 9.323870e-02 1.030 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 9.323870e-02 1.030 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 9.323870e-02 1.030 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 9.323870e-02 1.030 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 9.323870e-02 1.030 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 9.323870e-02 1.030 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 9.323870e-02 1.030 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.365494e-01 0.865 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.365494e-01 0.865 0 0
IKBKB deficiency causes SCID R-HSA-5602636 1.365494e-01 0.865 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 1.365494e-01 0.865 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.365494e-01 0.865 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 1.365494e-01 0.865 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.365494e-01 0.865 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.365494e-01 0.865 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 1.365494e-01 0.865 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 1.019787e-01 0.991 0 0
Type I hemidesmosome assembly R-HSA-446107 1.019787e-01 0.991 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.019787e-01 0.991 0 0
Formation of annular gap junctions R-HSA-196025 1.019787e-01 0.991 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.019787e-01 0.991 0 0
Gap junction degradation R-HSA-190873 1.176610e-01 0.929 0 0
CASP8 activity is inhibited R-HSA-5218900 1.176610e-01 0.929 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.338947e-01 0.873 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.148864e-01 0.940 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.254880e-01 0.901 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.254880e-01 0.901 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.254880e-01 0.901 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.254880e-01 0.901 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.254880e-01 0.901 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.182350e-01 0.927 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.265210e-01 0.898 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.350433e-01 0.870 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.350433e-01 0.870 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.489041e-02 1.023 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.265210e-01 0.898 0 0
Signal attenuation R-HSA-74749 1.338947e-01 0.873 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.364255e-01 0.865 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.354864e-01 0.868 0 0
Germ layer formation at gastrulation R-HSA-9754189 1.148864e-01 0.940 0 0
Regulation of CDH11 function R-HSA-9762292 1.338947e-01 0.873 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.213395e-01 0.916 0 0
G alpha (q) signalling events R-HSA-416476 1.097944e-01 0.959 0 0
Calcineurin activates NFAT R-HSA-2025928 1.176610e-01 0.929 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.364255e-01 0.865 0 0
Cyclin D associated events in G1 R-HSA-69231 1.145393e-01 0.941 0 0
G1 Phase R-HSA-69236 1.145393e-01 0.941 0 0
GABA receptor activation R-HSA-977443 1.200319e-01 0.921 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 1.346891e-01 0.871 0 0
Inhibition of PKR R-HSA-169131 9.323870e-02 1.030 1 1
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.365494e-01 0.865 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.365494e-01 0.865 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.019787e-01 0.991 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.019787e-01 0.991 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.176610e-01 0.929 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.176610e-01 0.929 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.156167e-01 0.937 0 0
Generic Transcription Pathway R-HSA-212436 1.274159e-01 0.895 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.176610e-01 0.929 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.669846e-02 1.015 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.338947e-01 0.873 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.528874e-02 1.021 0 0
Membrane Trafficking R-HSA-199991 1.156497e-01 0.937 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.249661e-01 0.903 0 0
NCAM signaling for neurite out-growth R-HSA-375165 1.322535e-01 0.879 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.138564e-02 1.039 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.024185e-01 0.990 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.365494e-01 0.865 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.176610e-01 0.929 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.350433e-01 0.870 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.200319e-01 0.921 0 0
MAP kinase activation R-HSA-450294 1.260703e-01 0.899 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.246472e-01 0.904 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 1.019787e-01 0.991 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.338947e-01 0.873 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.210620e-02 1.036 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.198290e-02 1.036 0 0
Adrenoceptors R-HSA-390696 1.019787e-01 0.991 0 0
Signaling by ERBB4 R-HSA-1236394 1.114658e-01 0.953 0 0
Signaling by Erythropoietin R-HSA-9006335 9.489041e-02 1.023 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.019787e-01 0.991 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 1.019787e-01 0.991 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.265210e-01 0.898 0 0
Signaling by PDGF R-HSA-186797 1.322535e-01 0.879 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.000770e-01 1.000 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.385783e-01 0.858 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.437540e-01 0.842 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.437918e-01 0.842 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.437918e-01 0.842 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.437918e-01 0.842 0 0
Mitophagy R-HSA-5205647 1.437918e-01 0.842 0 0
Signaling by Hedgehog R-HSA-5358351 1.441211e-01 0.841 0 0
Signaling by MET R-HSA-6806834 1.444039e-01 0.840 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.456627e-01 0.837 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 1.476748e-01 0.831 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.488969e-01 0.827 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.488969e-01 0.827 0 0
Formation of the posterior neural plate R-HSA-9832991 1.505916e-01 0.822 0 0
Interleukin-2 signaling R-HSA-9020558 1.505916e-01 0.822 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.505916e-01 0.822 0 0
Autophagy R-HSA-9612973 1.514346e-01 0.820 0 0
Ub-specific processing proteases R-HSA-5689880 1.535850e-01 0.814 0 0
Macroautophagy R-HSA-1632852 1.573724e-01 0.803 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.584884e-01 0.800 0 0
Potassium Channels R-HSA-1296071 1.584884e-01 0.800 0 0
Hemostasis R-HSA-109582 1.588241e-01 0.799 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.590666e-01 0.798 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.590666e-01 0.798 0 0
FCERI mediated MAPK activation R-HSA-2871796 1.590666e-01 0.798 0 0
Notch-HLH transcription pathway R-HSA-350054 1.592118e-01 0.798 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 1.592118e-01 0.798 0 0
G1/S-Specific Transcription R-HSA-69205 1.619255e-01 0.791 0 0
FLT3 signaling in disease R-HSA-9682385 1.619255e-01 0.791 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 1.777939e-01 0.750 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 1.777939e-01 0.750 0 0
Potassium transport channels R-HSA-1296067 1.777939e-01 0.750 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 1.777939e-01 0.750 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 2.170707e-01 0.663 0 0
Classical Kir channels R-HSA-1296053 2.170707e-01 0.663 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 2.544735e-01 0.594 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.544735e-01 0.594 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.544735e-01 0.594 0 0
Nucleotide catabolism defects R-HSA-9735786 2.544735e-01 0.594 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.544735e-01 0.594 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.544735e-01 0.594 0 0
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 2.544735e-01 0.594 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.544735e-01 0.594 0 0
IRS activation R-HSA-74713 2.900916e-01 0.537 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.900916e-01 0.537 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.900916e-01 0.537 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.900916e-01 0.537 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 2.900916e-01 0.537 0 0
Plus-strand DNA synthesis R-HSA-164525 3.240101e-01 0.489 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.240101e-01 0.489 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.240101e-01 0.489 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.240101e-01 0.489 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 2.026835e-01 0.693 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 2.204866e-01 0.657 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.564008e-01 0.591 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.564008e-01 0.591 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.953109e-01 0.709 0 0
Voltage gated Potassium channels R-HSA-1296072 1.712890e-01 0.766 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.924022e-01 0.534 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.905541e-01 0.720 0 0
PKA activation in glucagon signalling R-HSA-164378 3.103305e-01 0.508 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.460566e-01 0.609 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.004333e-01 0.698 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.819058e-01 0.740 0 0
EGFR downregulation R-HSA-182971 2.721590e-01 0.565 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.938510e-01 0.713 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.731400e-01 0.564 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.219214e-01 0.654 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.478838e-01 0.606 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 2.289664e-01 0.640 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.974502e-01 0.527 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.380509e-01 0.623 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.578628e-01 0.589 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.652487e-01 0.576 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.332529e-01 0.632 0 0
HCMV Early Events R-HSA-9609690 1.750081e-01 0.757 0 0
Neutrophil degranulation R-HSA-6798695 1.916677e-01 0.717 0 0
TGFBR3 expression R-HSA-9839394 1.953109e-01 0.709 0 0
DNA Double Strand Break Response R-HSA-5693606 3.068709e-01 0.513 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.103305e-01 0.508 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.207069e-01 0.656 0 0
G0 and Early G1 R-HSA-1538133 2.853222e-01 0.545 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 2.726923e-01 0.564 0 0
GAB1 signalosome R-HSA-180292 3.103305e-01 0.508 0 0
Processing of SMDT1 R-HSA-8949664 2.026835e-01 0.693 0 0
Peptide chain elongation R-HSA-156902 2.012703e-01 0.696 0 0
FOXO-mediated transcription R-HSA-9614085 2.953339e-01 0.530 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 2.564008e-01 0.591 0 0
Activation of SMO R-HSA-5635838 2.564008e-01 0.591 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.250401e-01 0.488 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.603236e-01 0.584 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.067385e-01 0.513 0 0
RAS processing R-HSA-9648002 1.905541e-01 0.720 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.067385e-01 0.513 0 0
Regulation of gap junction activity R-HSA-191650 2.544735e-01 0.594 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.384097e-01 0.623 0 0
PKA activation R-HSA-163615 3.103305e-01 0.508 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.012852e-01 0.696 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.564008e-01 0.591 0 0
Insulin receptor signalling cascade R-HSA-74751 2.787622e-01 0.555 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.819058e-01 0.740 0 0
Inwardly rectifying K+ channels R-HSA-1296065 2.853222e-01 0.545 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.905541e-01 0.720 0 0
Resolution of D-Loop Structures R-HSA-5693537 3.117801e-01 0.506 0 0
TNF signaling R-HSA-75893 2.070520e-01 0.684 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 2.900916e-01 0.537 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.026835e-01 0.693 0 0
DCC mediated attractive signaling R-HSA-418885 2.384097e-01 0.623 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.309216e-01 0.637 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.985351e-01 0.525 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.985351e-01 0.525 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.380509e-01 0.623 0 0
Adipogenesis R-HSA-9843745 2.959588e-01 0.529 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.731400e-01 0.564 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.117801e-01 0.506 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 2.026835e-01 0.693 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 2.726923e-01 0.564 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.156776e-01 0.666 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.544735e-01 0.594 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.544735e-01 0.594 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.900916e-01 0.537 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 3.240101e-01 0.489 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 2.384097e-01 0.623 0 0
Eukaryotic Translation Termination R-HSA-72764 2.652487e-01 0.576 0 0
Ca2+ pathway R-HSA-4086398 2.088220e-01 0.680 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.695083e-01 0.569 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.590640e-01 0.587 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.850573e-01 0.733 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.590640e-01 0.587 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.744126e-01 0.562 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.905541e-01 0.720 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.777939e-01 0.750 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 1.777939e-01 0.750 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.170707e-01 0.663 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 2.544735e-01 0.594 0 0
Dopamine receptors R-HSA-390651 2.544735e-01 0.594 0 0
ATP sensitive Potassium channels R-HSA-1296025 2.544735e-01 0.594 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.900916e-01 0.537 0 0
NTRK2 activates RAC1 R-HSA-9032759 2.900916e-01 0.537 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.676707e-01 0.776 0 0
Synthesis of PS R-HSA-1483101 3.240101e-01 0.489 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.240101e-01 0.489 0 0
Phosphorylation of Emi1 R-HSA-176417 3.240101e-01 0.489 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.564008e-01 0.591 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.203847e-01 0.657 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.331566e-01 0.632 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 2.004333e-01 0.698 0 0
Diseases of Immune System R-HSA-5260271 2.004333e-01 0.698 0 0
HSF1-dependent transactivation R-HSA-3371571 1.658166e-01 0.780 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.865237e-01 0.729 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 1.938510e-01 0.713 0 0
Regulation of mitotic cell cycle R-HSA-453276 1.938510e-01 0.713 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.250401e-01 0.488 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.512149e-01 0.600 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.859008e-01 0.544 0 0
G alpha (s) signalling events R-HSA-418555 2.257412e-01 0.646 0 0
Signaling by WNT R-HSA-195721 2.990311e-01 0.524 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.360864e-01 0.627 0 0
Signaling by TGFBR3 R-HSA-9839373 2.731400e-01 0.564 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.325350e-01 0.634 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 1.955323e-01 0.709 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.012852e-01 0.696 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.544735e-01 0.594 0 0
HATs acetylate histones R-HSA-3214847 1.756256e-01 0.755 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.112076e-01 0.507 0 0
Interferon Signaling R-HSA-913531 1.947169e-01 0.711 1 0
Cellular response to chemical stress R-HSA-9711123 2.506922e-01 0.601 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.641105e-01 0.785 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 2.204866e-01 0.657 0 0
Regulation of KIT signaling R-HSA-1433559 2.204866e-01 0.657 0 0
Regulation of BACH1 activity R-HSA-9708530 2.564008e-01 0.591 0 0
Developmental Cell Lineages R-HSA-9734767 2.295004e-01 0.639 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.905493e-01 0.720 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 2.700244e-01 0.569 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.624506e-01 0.581 0 0
Intracellular oxygen transport R-HSA-8981607 2.170707e-01 0.663 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.170707e-01 0.663 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.170707e-01 0.663 0 0
NADE modulates death signalling R-HSA-205025 2.544735e-01 0.594 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.900916e-01 0.537 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.240101e-01 0.489 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 3.240101e-01 0.489 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.240101e-01 0.489 0 0
CD28 dependent Vav1 pathway R-HSA-389359 2.026835e-01 0.693 0 0
Pyroptosis R-HSA-5620971 2.331566e-01 0.632 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.103305e-01 0.508 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.240101e-01 0.489 0 0
Intra-Golgi traffic R-HSA-6811438 2.206283e-01 0.656 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.749848e-01 0.757 0 0
Degradation of CDH1 R-HSA-9766229 3.055982e-01 0.515 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.829092e-01 0.548 0 0
HDMs demethylate histones R-HSA-3214842 1.953109e-01 0.709 0 0
Histamine receptors R-HSA-390650 2.170707e-01 0.663 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.206283e-01 0.656 0 0
Interleukin-17 signaling R-HSA-448424 1.865237e-01 0.729 0 0
Selenocysteine synthesis R-HSA-2408557 3.106518e-01 0.508 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.250401e-01 0.488 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.103305e-01 0.508 0 0
Formation of the anterior neural plate R-HSA-9823739 2.384097e-01 0.623 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.924022e-01 0.534 0 0
Diseases of DNA repair R-HSA-9675135 2.731400e-01 0.564 0 0
Co-stimulation by CD28 R-HSA-389356 2.947242e-01 0.531 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.777939e-01 0.750 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.170707e-01 0.663 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.900916e-01 0.537 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.900916e-01 0.537 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.850573e-01 0.733 0 0
VEGF ligand-receptor interactions R-HSA-194313 3.240101e-01 0.489 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.710126e-01 0.767 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.722550e-01 0.565 0 0
Deubiquitination R-HSA-5688426 1.973090e-01 0.705 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.938510e-01 0.713 0 0
Chromatin organization R-HSA-4839726 1.746936e-01 0.758 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.590640e-01 0.587 0 0
Chromatin modifying enzymes R-HSA-3247509 1.866630e-01 0.729 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.850573e-01 0.733 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 1.953109e-01 0.709 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 2.331566e-01 0.632 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.787622e-01 0.555 0 0
Apoptotic factor-mediated response R-HSA-111471 3.103305e-01 0.508 0 0
Regulated Necrosis R-HSA-5218859 3.163339e-01 0.500 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.900916e-01 0.537 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.676707e-01 0.776 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.240101e-01 0.489 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.384097e-01 0.623 0 0
Synthesis of PG R-HSA-1483148 2.744126e-01 0.562 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.231881e-01 0.491 0 0
Amine ligand-binding receptors R-HSA-375280 2.518438e-01 0.599 0 0
TRAIL signaling R-HSA-75158 3.240101e-01 0.489 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.240101e-01 0.489 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.240101e-01 0.489 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.985351e-01 0.525 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.077622e-01 0.682 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 2.026835e-01 0.693 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.900916e-01 0.537 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.240101e-01 0.489 0 0
Signaling by ALK R-HSA-201556 1.905541e-01 0.720 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.103305e-01 0.508 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.026835e-01 0.693 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.924022e-01 0.534 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 2.026835e-01 0.693 0 0
FLT3 Signaling R-HSA-9607240 2.104618e-01 0.677 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 2.924022e-01 0.534 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.103305e-01 0.508 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 2.204866e-01 0.657 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.225001e-01 0.491 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.077622e-01 0.682 0 0
Signaling by FGFR3 in disease R-HSA-5655332 2.203847e-01 0.657 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 1.830534e-01 0.737 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 3.258328e-01 0.487 0 0
Viral mRNA Translation R-HSA-192823 3.261153e-01 0.487 0 0
The NLRP3 inflammasome R-HSA-844456 3.281625e-01 0.484 0 0
Maturation of nucleoprotein R-HSA-9694631 3.281625e-01 0.484 0 0
Other interleukin signaling R-HSA-449836 3.281625e-01 0.484 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 3.281625e-01 0.484 0 0
Cilium Assembly R-HSA-5617833 3.287713e-01 0.483 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.338930e-01 0.476 0 0
Toll-like Receptor Cascades R-HSA-168898 3.344919e-01 0.476 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.353611e-01 0.474 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.359177e-01 0.474 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.382990e-01 0.471 0 0
Neurexins and neuroligins R-HSA-6794361 3.384279e-01 0.471 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 3.413577e-01 0.467 0 0
Leishmania parasite growth and survival R-HSA-9664433 3.413577e-01 0.467 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.416965e-01 0.466 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.416965e-01 0.466 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.458665e-01 0.461 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.458665e-01 0.461 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 3.458665e-01 0.461 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.494085e-01 0.457 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.515412e-01 0.454 0 0
rRNA processing R-HSA-72312 3.533292e-01 0.452 0 0
PTEN Regulation R-HSA-6807070 3.562414e-01 0.448 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.563099e-01 0.448 0 0
Uncoating of the HIV Virion R-HSA-162585 3.563099e-01 0.448 0 0
NADPH regeneration R-HSA-389542 3.563099e-01 0.448 0 0
Abacavir transmembrane transport R-HSA-2161517 3.563099e-01 0.448 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.563099e-01 0.448 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.563099e-01 0.448 0 0
Leukotriene receptors R-HSA-391906 3.563099e-01 0.448 0 0
Nef and signal transduction R-HSA-164944 3.563099e-01 0.448 0 0
Translation initiation complex formation R-HSA-72649 3.603925e-01 0.443 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.603925e-01 0.443 0 0
G-protein activation R-HSA-202040 3.634141e-01 0.440 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 3.634141e-01 0.440 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.634141e-01 0.440 0 0
Basigin interactions R-HSA-210991 3.634141e-01 0.440 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.647522e-01 0.438 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.652281e-01 0.437 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.653001e-01 0.437 0 0
Signaling by NOTCH3 R-HSA-9012852 3.713712e-01 0.430 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.736439e-01 0.428 0 0
IRE1alpha activates chaperones R-HSA-381070 3.739070e-01 0.427 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.779181e-01 0.423 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.779181e-01 0.423 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.789833e-01 0.421 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.789833e-01 0.421 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.789833e-01 0.421 0 0
G1/S Transition R-HSA-69206 3.789833e-01 0.421 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 3.807799e-01 0.419 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.823360e-01 0.418 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.870683e-01 0.412 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.870683e-01 0.412 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 3.870683e-01 0.412 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.870683e-01 0.412 0 0
Disinhibition of SNARE formation R-HSA-114516 3.870683e-01 0.412 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.870683e-01 0.412 0 0
Ca2+ activated K+ channels R-HSA-1296052 3.870683e-01 0.412 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.870683e-01 0.412 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.870683e-01 0.412 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.870683e-01 0.412 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.870683e-01 0.412 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.870683e-01 0.412 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.870683e-01 0.412 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.904161e-01 0.408 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.910256e-01 0.408 1 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 3.910256e-01 0.408 0 0
Immune System R-HSA-168256 3.915694e-01 0.407 1 0
IRS-mediated signalling R-HSA-112399 3.932790e-01 0.405 0 0
FGFR2 alternative splicing R-HSA-6803529 3.979411e-01 0.400 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 3.979411e-01 0.400 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.979411e-01 0.400 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.997438e-01 0.398 0 0
Selenoamino acid metabolism R-HSA-2408522 4.001588e-01 0.398 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.040625e-01 0.394 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.040625e-01 0.394 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.040625e-01 0.394 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.041921e-01 0.393 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.083477e-01 0.389 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.148778e-01 0.382 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.148778e-01 0.382 0 0
Syndecan interactions R-HSA-3000170 4.148778e-01 0.382 0 0
Reverse Transcription of HIV RNA R-HSA-162589 4.163587e-01 0.381 0 0
Minus-strand DNA synthesis R-HSA-164516 4.163587e-01 0.381 0 0
Regulation by c-FLIP R-HSA-3371378 4.163587e-01 0.381 0 0
RSK activation R-HSA-444257 4.163587e-01 0.381 0 0
Dimerization of procaspase-8 R-HSA-69416 4.163587e-01 0.381 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.163587e-01 0.381 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 4.163587e-01 0.381 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.163587e-01 0.381 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.163587e-01 0.381 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.163587e-01 0.381 0 0
Sodium/Proton exchangers R-HSA-425986 4.163587e-01 0.381 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.163587e-01 0.381 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.170171e-01 0.380 0 0
Innate Immune System R-HSA-168249 4.199605e-01 0.377 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.284126e-01 0.368 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 4.298784e-01 0.367 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 4.309370e-01 0.366 0 0
Deadenylation of mRNA R-HSA-429947 4.315721e-01 0.365 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 4.315721e-01 0.365 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.315721e-01 0.365 0 0
Neurodegenerative Diseases R-HSA-8863678 4.315721e-01 0.365 0 0
Formation of paraxial mesoderm R-HSA-9793380 4.366785e-01 0.360 0 0
G alpha (i) signalling events R-HSA-418594 4.374023e-01 0.359 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.426363e-01 0.354 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.442511e-01 0.352 0 0
ALK mutants bind TKIs R-HSA-9700645 4.442511e-01 0.352 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.442511e-01 0.352 0 0
ARMS-mediated activation R-HSA-170984 4.442511e-01 0.352 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.442511e-01 0.352 0 0
WNT mediated activation of DVL R-HSA-201688 4.442511e-01 0.352 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.442511e-01 0.352 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.442511e-01 0.352 0 0
Interleukin-1 processing R-HSA-448706 4.442511e-01 0.352 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.442511e-01 0.352 0 0
Cellular response to mitochondrial stress R-HSA-9840373 4.442511e-01 0.352 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 4.442511e-01 0.352 0 0
Heme signaling R-HSA-9707616 4.473999e-01 0.349 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.473999e-01 0.349 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.480088e-01 0.349 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.480088e-01 0.349 0 0
Hyaluronan degradation R-HSA-2160916 4.480088e-01 0.349 0 0
HCMV Infection R-HSA-9609646 4.504936e-01 0.346 0 0
TBC/RABGAPs R-HSA-8854214 4.552811e-01 0.342 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.552811e-01 0.342 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.552811e-01 0.342 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.580566e-01 0.339 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.580566e-01 0.339 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.580566e-01 0.339 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.589341e-01 0.338 0 0
Mitochondrial biogenesis R-HSA-1592230 4.595983e-01 0.338 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 4.641742e-01 0.333 0 0
Myogenesis R-HSA-525793 4.641742e-01 0.333 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.641742e-01 0.333 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.641742e-01 0.333 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 4.641742e-01 0.333 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.657387e-01 0.332 0 0
Interleukin-1 signaling R-HSA-9020702 4.680613e-01 0.330 0 0
Binding and entry of HIV virion R-HSA-173107 4.708121e-01 0.327 0 0
PI3K/AKT activation R-HSA-198203 4.708121e-01 0.327 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.708121e-01 0.327 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.708121e-01 0.327 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.708121e-01 0.327 0 0
Maturation of spike protein R-HSA-9683686 4.708121e-01 0.327 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.708121e-01 0.327 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.708121e-01 0.327 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.708121e-01 0.327 0 0
Signaling by Leptin R-HSA-2586552 4.708121e-01 0.327 0 0
PPARA activates gene expression R-HSA-1989781 4.725271e-01 0.326 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.725271e-01 0.326 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.777025e-01 0.321 0 0
Meiosis R-HSA-1500620 4.778406e-01 0.321 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.778406e-01 0.321 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.800567e-01 0.319 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.800567e-01 0.319 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.800567e-01 0.319 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.800567e-01 0.319 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.800567e-01 0.319 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.800567e-01 0.319 0 0
Maturation of hRSV A proteins R-HSA-9828806 4.800567e-01 0.319 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.801970e-01 0.319 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.801970e-01 0.319 0 0
Somitogenesis R-HSA-9824272 4.801970e-01 0.319 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 4.860480e-01 0.313 0 0
Ribosome-associated quality control R-HSA-9948299 4.881759e-01 0.311 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.895807e-01 0.310 0 0
Chromosome Maintenance R-HSA-73886 4.905303e-01 0.309 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.905303e-01 0.309 0 0
Cellular response to heat stress R-HSA-3371556 4.905303e-01 0.309 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.924522e-01 0.308 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 4.924522e-01 0.308 0 0
Response of endothelial cells to shear stress R-HSA-9860931 4.931835e-01 0.307 0 0
DNA Repair R-HSA-73894 4.939520e-01 0.306 0 0
Vesicle-mediated transport R-HSA-5653656 4.946692e-01 0.306 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.953224e-01 0.305 0 0
Telomere Extension By Telomerase R-HSA-171319 4.956465e-01 0.305 0 0
HIV elongation arrest and recovery R-HSA-167287 4.956465e-01 0.305 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.956465e-01 0.305 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 4.956465e-01 0.305 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.956465e-01 0.305 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.956465e-01 0.305 0 0
Inflammasomes R-HSA-622312 4.956465e-01 0.305 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.961052e-01 0.304 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.961052e-01 0.304 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 4.961052e-01 0.304 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.961052e-01 0.304 0 0
Bicarbonate transporters R-HSA-425381 4.961052e-01 0.304 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.961052e-01 0.304 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.961052e-01 0.304 0 0
PECAM1 interactions R-HSA-210990 4.961052e-01 0.304 0 0
Suppression of apoptosis R-HSA-9635465 4.961052e-01 0.304 0 0
Prostanoid ligand receptors R-HSA-391908 4.961052e-01 0.304 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.961052e-01 0.304 0 0
Influenza Infection R-HSA-168255 5.031723e-01 0.298 1 0
Signaling by NOTCH R-HSA-157118 5.068135e-01 0.295 0 0
Transcription of the HIV genome R-HSA-167172 5.101712e-01 0.292 0 0
Platelet calcium homeostasis R-HSA-418360 5.109354e-01 0.292 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.109354e-01 0.292 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.109354e-01 0.292 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.122320e-01 0.291 0 0
Diseases of programmed cell death R-HSA-9645723 5.144097e-01 0.289 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.165223e-01 0.287 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.178999e-01 0.286 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.184882e-01 0.285 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.201908e-01 0.284 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.201908e-01 0.284 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 5.201908e-01 0.284 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.201908e-01 0.284 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.201908e-01 0.284 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.201908e-01 0.284 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.201908e-01 0.284 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.201908e-01 0.284 0 0
Sodium/Calcium exchangers R-HSA-425561 5.201908e-01 0.284 0 0
Integration of provirus R-HSA-162592 5.201908e-01 0.284 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.201908e-01 0.284 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.259163e-01 0.279 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.259163e-01 0.279 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.259163e-01 0.279 0 0
Interleukin-37 signaling R-HSA-9008059 5.259163e-01 0.279 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.399655e-01 0.268 0 0
Hedgehog 'on' state R-HSA-5632684 5.403246e-01 0.267 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.405840e-01 0.267 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.405840e-01 0.267 0 0
Cargo concentration in the ER R-HSA-5694530 5.405840e-01 0.267 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.405840e-01 0.267 1 1
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.431266e-01 0.265 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.431266e-01 0.265 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.431266e-01 0.265 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 5.431266e-01 0.265 0 0
Interleukin-15 signaling R-HSA-8983432 5.431266e-01 0.265 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 5.431266e-01 0.265 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.431266e-01 0.265 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.431266e-01 0.265 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.431266e-01 0.265 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.431266e-01 0.265 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.431266e-01 0.265 0 0
Pervasive developmental disorders R-HSA-9005895 5.431266e-01 0.265 0 0
Disorders of Nervous System Development R-HSA-9697154 5.431266e-01 0.265 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.431266e-01 0.265 0 0
G2/M Checkpoints R-HSA-69481 5.432584e-01 0.265 0 0
Meiotic recombination R-HSA-912446 5.514392e-01 0.259 0 0
The phototransduction cascade R-HSA-2514856 5.514392e-01 0.259 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.549340e-01 0.256 0 0
Signaling by Insulin receptor R-HSA-74752 5.585446e-01 0.253 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.598918e-01 0.252 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.627418e-01 0.250 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.649673e-01 0.248 0 0
Adenylate cyclase activating pathway R-HSA-170660 5.649673e-01 0.248 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.649673e-01 0.248 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.649673e-01 0.248 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.649673e-01 0.248 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.649673e-01 0.248 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.649673e-01 0.248 0 0
Frs2-mediated activation R-HSA-170968 5.649673e-01 0.248 0 0
Diseases of nucleotide metabolism R-HSA-9735804 5.649673e-01 0.248 0 0
FGFR1c ligand binding and activation R-HSA-190373 5.649673e-01 0.248 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 5.649673e-01 0.248 0 0
Formation of axial mesoderm R-HSA-9796292 5.649673e-01 0.248 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 5.649673e-01 0.248 0 0
Maturation of nucleoprotein R-HSA-9683610 5.649673e-01 0.248 0 0
Interleukin-6 signaling R-HSA-1059683 5.649673e-01 0.248 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 5.689633e-01 0.245 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.689633e-01 0.245 0 0
Nuclear RNA decay R-HSA-9930044 5.689633e-01 0.245 0 0
G-protein beta:gamma signalling R-HSA-397795 5.689633e-01 0.245 0 0
Cardiogenesis R-HSA-9733709 5.689633e-01 0.245 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.689633e-01 0.245 0 0
Regulation of necroptotic cell death R-HSA-5675482 5.689633e-01 0.245 0 0
Signaling by NOTCH4 R-HSA-9013694 5.695045e-01 0.245 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.695045e-01 0.245 0 0
Signaling by FGFR in disease R-HSA-1226099 5.695045e-01 0.245 0 0
Gastrulation R-HSA-9758941 5.716326e-01 0.243 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.735906e-01 0.241 0 0
Meiotic synapsis R-HSA-1221632 5.738694e-01 0.241 0 0
Centrosome maturation R-HSA-380287 5.789992e-01 0.237 0 0
Protein ubiquitination R-HSA-8852135 5.789992e-01 0.237 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.789992e-01 0.237 1 1
Cellular responses to mechanical stimuli R-HSA-9855142 5.812864e-01 0.236 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.826697e-01 0.235 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.826697e-01 0.235 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.826697e-01 0.235 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.848189e-01 0.233 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.857652e-01 0.232 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.857652e-01 0.232 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.857652e-01 0.232 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.857652e-01 0.232 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.857652e-01 0.232 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.857652e-01 0.232 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.857652e-01 0.232 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.857652e-01 0.232 0 0
HDL assembly R-HSA-8963896 5.857652e-01 0.232 0 0
Signal regulatory protein family interactions R-HSA-391160 5.857652e-01 0.232 0 0
P2Y receptors R-HSA-417957 5.857652e-01 0.232 0 0
UCH proteinases R-HSA-5689603 5.883732e-01 0.230 0 0
Interleukin-1 family signaling R-HSA-446652 5.915401e-01 0.228 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.923631e-01 0.227 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.935873e-01 0.227 0 0
HDACs deacetylate histones R-HSA-3214815 5.955872e-01 0.225 0 0
Nuclear import of Rev protein R-HSA-180746 5.960520e-01 0.225 0 0
Hyaluronan metabolism R-HSA-2142845 5.960520e-01 0.225 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.960520e-01 0.225 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.960520e-01 0.225 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.055700e-01 0.218 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.055700e-01 0.218 0 0
Telomere C-strand synthesis initiation R-HSA-174430 6.055700e-01 0.218 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.055700e-01 0.218 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.055700e-01 0.218 0 0
Transport and metabolism of PAPS R-HSA-174362 6.055700e-01 0.218 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.055700e-01 0.218 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.055700e-01 0.218 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.061720e-01 0.217 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.061720e-01 0.217 0 0
Telomere Maintenance R-HSA-157579 6.087244e-01 0.216 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.087244e-01 0.216 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 6.091099e-01 0.215 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 6.157475e-01 0.211 0 0
Regulation of insulin secretion R-HSA-422356 6.167614e-01 0.210 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 6.218438e-01 0.206 0 0
RUNX2 regulates bone development R-HSA-8941326 6.218438e-01 0.206 0 0
Triglyceride catabolism R-HSA-163560 6.218438e-01 0.206 0 0
GPVI-mediated activation cascade R-HSA-114604 6.218438e-01 0.206 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.244291e-01 0.205 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.244291e-01 0.205 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.244291e-01 0.205 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.244291e-01 0.205 0 0
Activation of the phototransduction cascade R-HSA-2485179 6.244291e-01 0.205 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.244291e-01 0.205 0 0
Phosphorylation of the APC/C R-HSA-176412 6.244291e-01 0.205 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.244291e-01 0.205 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.244291e-01 0.205 0 0
Killing mechanisms R-HSA-9664420 6.244291e-01 0.205 0 0
Prolonged ERK activation events R-HSA-169893 6.244291e-01 0.205 0 0
Negative regulation of FLT3 R-HSA-9706369 6.244291e-01 0.205 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.244291e-01 0.205 0 0
Atorvastatin ADME R-HSA-9754706 6.244291e-01 0.205 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 6.267831e-01 0.203 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.267831e-01 0.203 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.277500e-01 0.202 1 0
Glycolysis R-HSA-70171 6.325402e-01 0.199 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.333542e-01 0.198 0 0
Cleavage of the damaged purine R-HSA-110331 6.342548e-01 0.198 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.342548e-01 0.198 0 0
Interferon gamma signaling R-HSA-877300 6.361539e-01 0.196 0 0
Metabolism of non-coding RNA R-HSA-194441 6.368064e-01 0.196 0 0
snRNP Assembly R-HSA-191859 6.368064e-01 0.196 0 0
Extension of Telomeres R-HSA-180786 6.368064e-01 0.196 0 0
Peroxisomal protein import R-HSA-9033241 6.368064e-01 0.196 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 6.368064e-01 0.196 0 0
Triglyceride metabolism R-HSA-8979227 6.368064e-01 0.196 0 0
Signaling by TGFB family members R-HSA-9006936 6.423019e-01 0.192 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.423875e-01 0.192 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.423875e-01 0.192 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.423875e-01 0.192 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.423875e-01 0.192 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.423875e-01 0.192 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.423875e-01 0.192 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.423875e-01 0.192 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.423875e-01 0.192 0 0
Disorders of Developmental Biology R-HSA-9675151 6.423875e-01 0.192 0 0
Depurination R-HSA-73927 6.463447e-01 0.190 0 0
MET promotes cell motility R-HSA-8875878 6.463447e-01 0.190 0 0
Purine salvage R-HSA-74217 6.463447e-01 0.190 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.463447e-01 0.190 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 6.463447e-01 0.190 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.466400e-01 0.189 0 0
PI Metabolism R-HSA-1483255 6.479164e-01 0.188 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.504322e-01 0.187 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.554396e-01 0.183 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.562834e-01 0.183 0 0
Nucleotide salvage R-HSA-8956321 6.562834e-01 0.183 0 0
Stabilization of p53 R-HSA-69541 6.581158e-01 0.182 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 6.581158e-01 0.182 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.581158e-01 0.182 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 6.587700e-01 0.181 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.594883e-01 0.181 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.594883e-01 0.181 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.594883e-01 0.181 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 6.594883e-01 0.181 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.594883e-01 0.181 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 6.594883e-01 0.181 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.594883e-01 0.181 0 0
Sulfide oxidation to sulfate R-HSA-1614517 6.594883e-01 0.181 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.594883e-01 0.181 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.665365e-01 0.176 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 6.665365e-01 0.176 0 0
Host Interactions of HIV factors R-HSA-162909 6.676758e-01 0.175 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.685520e-01 0.175 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.695710e-01 0.174 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.695710e-01 0.174 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.695710e-01 0.174 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.695710e-01 0.174 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.695710e-01 0.174 0 0
Interleukin-2 family signaling R-HSA-451927 6.695710e-01 0.174 0 0
Attenuation phase R-HSA-3371568 6.695710e-01 0.174 0 0
HIV Transcription Elongation R-HSA-167169 6.695710e-01 0.174 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 6.695710e-01 0.174 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.695710e-01 0.174 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.695710e-01 0.174 0 0
Generation of second messenger molecules R-HSA-202433 6.695710e-01 0.174 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.757723e-01 0.170 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.757723e-01 0.170 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.757723e-01 0.170 0 0
Mismatch Repair R-HSA-5358508 6.757723e-01 0.170 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.757723e-01 0.170 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.757723e-01 0.170 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.757723e-01 0.170 0 0
Platelet sensitization by LDL R-HSA-432142 6.757723e-01 0.170 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 6.757723e-01 0.170 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.807135e-01 0.167 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.807135e-01 0.167 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.807135e-01 0.167 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.807135e-01 0.167 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.807135e-01 0.167 0 0
Disease R-HSA-1643685 6.821162e-01 0.166 1 0
Infectious disease R-HSA-5663205 6.853410e-01 0.164 1 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.912785e-01 0.160 0 0
Regulation of signaling by CBL R-HSA-912631 6.912785e-01 0.160 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.912785e-01 0.160 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.912785e-01 0.160 0 0
Translesion Synthesis by POLH R-HSA-110320 6.912785e-01 0.160 0 0
HIV Transcription Initiation R-HSA-167161 6.915470e-01 0.160 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.915470e-01 0.160 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.915470e-01 0.160 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.915470e-01 0.160 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.915470e-01 0.160 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.915470e-01 0.160 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.915470e-01 0.160 0 0
Translation of Structural Proteins R-HSA-9683701 6.915470e-01 0.160 0 0
Cellular response to hypoxia R-HSA-1234174 6.929503e-01 0.159 0 0
Platelet degranulation R-HSA-114608 6.938193e-01 0.159 0 0
Adaptive Immune System R-HSA-1280218 6.973670e-01 0.157 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.984498e-01 0.156 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.020756e-01 0.154 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.020756e-01 0.154 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.020756e-01 0.154 0 0
MTOR signalling R-HSA-165159 7.020756e-01 0.154 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.020756e-01 0.154 0 0
Depyrimidination R-HSA-73928 7.020756e-01 0.154 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 7.020756e-01 0.154 0 0
S Phase R-HSA-69242 7.027435e-01 0.153 0 0
ER-Phagosome pathway R-HSA-1236974 7.059391e-01 0.151 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.060440e-01 0.151 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 7.060440e-01 0.151 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.060440e-01 0.151 0 0
Negative regulation of MET activity R-HSA-6807004 7.060440e-01 0.151 0 0
Signaling by NODAL R-HSA-1181150 7.060440e-01 0.151 0 0
Formation of definitive endoderm R-HSA-9823730 7.060440e-01 0.151 0 0
Protein hydroxylation R-HSA-9629569 7.060440e-01 0.151 0 0
Nephrin family interactions R-HSA-373753 7.060440e-01 0.151 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.101448e-01 0.149 0 0
Cell surface interactions at the vascular wall R-HSA-202733 7.121194e-01 0.147 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.123036e-01 0.147 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.133217e-01 0.147 0 0
Potential therapeutics for SARS R-HSA-9679191 7.142189e-01 0.146 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.184601e-01 0.144 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 7.201042e-01 0.143 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.201042e-01 0.143 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.201042e-01 0.143 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.201042e-01 0.143 0 0
ERK/MAPK targets R-HSA-198753 7.201042e-01 0.143 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 7.201042e-01 0.143 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 7.201042e-01 0.143 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.205667e-01 0.142 0 0
Surfactant metabolism R-HSA-5683826 7.222358e-01 0.141 0 0
Inositol phosphate metabolism R-HSA-1483249 7.249798e-01 0.140 0 0
Circadian clock R-HSA-9909396 7.304010e-01 0.136 0 0
Nucleosome assembly R-HSA-774815 7.318770e-01 0.136 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 7.318770e-01 0.136 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 7.318770e-01 0.136 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.318770e-01 0.136 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.318770e-01 0.136 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.318770e-01 0.136 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.334926e-01 0.135 0 0
Eicosanoids R-HSA-211979 7.334926e-01 0.135 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.334926e-01 0.135 0 0
Miscellaneous substrates R-HSA-211958 7.334926e-01 0.135 0 0
Ribavirin ADME R-HSA-9755088 7.334926e-01 0.135 0 0
Assembly Of The HIV Virion R-HSA-175474 7.334926e-01 0.135 0 0
Viral Infection Pathways R-HSA-9824446 7.376110e-01 0.132 1 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.412323e-01 0.130 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.412323e-01 0.130 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.412323e-01 0.130 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.414899e-01 0.130 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.422940e-01 0.129 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.462415e-01 0.127 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.462415e-01 0.127 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.462415e-01 0.127 0 0
mTORC1-mediated signalling R-HSA-166208 7.462415e-01 0.127 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.462415e-01 0.127 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.462415e-01 0.127 0 0
HIV Life Cycle R-HSA-162587 7.520042e-01 0.124 0 0
SARS-CoV Infections R-HSA-9679506 7.556235e-01 0.122 0 0
Cellular response to starvation R-HSA-9711097 7.570992e-01 0.121 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.583812e-01 0.120 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.583812e-01 0.120 0 0
Fatty acids R-HSA-211935 7.583812e-01 0.120 0 0
Growth hormone receptor signaling R-HSA-982772 7.583812e-01 0.120 0 0
Integration of energy metabolism R-HSA-163685 7.584480e-01 0.120 0 0
Metal ion SLC transporters R-HSA-425410 7.591064e-01 0.120 0 0
HIV Infection R-HSA-162906 7.671596e-01 0.115 0 0
Glucose metabolism R-HSA-70326 7.672837e-01 0.115 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 7.676362e-01 0.115 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.676362e-01 0.115 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.676362e-01 0.115 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.699408e-01 0.114 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.699408e-01 0.114 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.699408e-01 0.114 0 0
Complex III assembly R-HSA-9865881 7.699408e-01 0.114 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.699408e-01 0.114 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.699408e-01 0.114 0 0
Interleukin-6 family signaling R-HSA-6783589 7.699408e-01 0.114 0 0
Azathioprine ADME R-HSA-9748787 7.759021e-01 0.110 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.784142e-01 0.109 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.784195e-01 0.109 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.809481e-01 0.107 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.809481e-01 0.107 0 0
G protein gated Potassium channels R-HSA-1296059 7.809481e-01 0.107 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.809481e-01 0.107 0 0
Tight junction interactions R-HSA-420029 7.809481e-01 0.107 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 7.809481e-01 0.107 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.809481e-01 0.107 0 0
Formation of the nephric duct R-HSA-9830364 7.809481e-01 0.107 0 0
Laminin interactions R-HSA-3000157 7.809481e-01 0.107 0 0
Interleukin-7 signaling R-HSA-1266695 7.809481e-01 0.107 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.839096e-01 0.106 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.851163e-01 0.105 0 0
Translation of Structural Proteins R-HSA-9694635 7.851163e-01 0.105 0 0
MET activates PTK2 signaling R-HSA-8874081 7.914293e-01 0.102 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 7.914293e-01 0.102 0 0
Metalloprotease DUBs R-HSA-5689901 7.914293e-01 0.102 0 0
Abacavir ADME R-HSA-2161522 7.914293e-01 0.102 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.914293e-01 0.102 0 0
RNA Polymerase I Transcription R-HSA-73864 7.916498e-01 0.101 0 0
Integrin cell surface interactions R-HSA-216083 7.916498e-01 0.101 0 0
PCP/CE pathway R-HSA-4086400 7.916498e-01 0.101 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.916647e-01 0.101 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.916647e-01 0.101 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.916647e-01 0.101 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.916647e-01 0.101 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.991731e-01 0.097 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.991731e-01 0.097 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 7.994546e-01 0.097 0 0
Packaging Of Telomere Ends R-HSA-171306 8.014097e-01 0.096 0 0
Cristae formation R-HSA-8949613 8.014097e-01 0.096 0 0
Triglyceride biosynthesis R-HSA-75109 8.014097e-01 0.096 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.042210e-01 0.095 0 0
Prednisone ADME R-HSA-9757110 8.109130e-01 0.091 0 0
Pyrimidine salvage R-HSA-73614 8.109130e-01 0.091 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.134732e-01 0.090 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 8.188853e-01 0.087 0 0
DARPP-32 events R-HSA-180024 8.199622e-01 0.086 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.199622e-01 0.086 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.202766e-01 0.086 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.218773e-01 0.085 0 0
Nucleotide Excision Repair R-HSA-5696398 8.235715e-01 0.084 0 0
Synthesis of PA R-HSA-1483166 8.268567e-01 0.083 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 8.274533e-01 0.082 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.285788e-01 0.082 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.285788e-01 0.082 0 0
Activation of BH3-only proteins R-HSA-114452 8.285788e-01 0.082 0 0
Neurotransmitter clearance R-HSA-112311 8.285788e-01 0.082 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.332192e-01 0.079 0 0
Budding and maturation of HIV virion R-HSA-162588 8.367835e-01 0.077 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.367835e-01 0.077 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.367835e-01 0.077 0 0
Regulation of beta-cell development R-HSA-186712 8.393699e-01 0.076 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.393699e-01 0.076 0 0
Reproduction R-HSA-1474165 8.410128e-01 0.075 0 0
Protein localization R-HSA-9609507 8.416147e-01 0.075 0 0
HS-GAG degradation R-HSA-2024096 8.445960e-01 0.073 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.445960e-01 0.073 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.453144e-01 0.073 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.453144e-01 0.073 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.453144e-01 0.073 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.453144e-01 0.073 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.453144e-01 0.073 0 0
tRNA Aminoacylation R-HSA-379724 8.453144e-01 0.073 0 0
TCR signaling R-HSA-202403 8.471265e-01 0.072 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.510585e-01 0.070 0 0
Aquaporin-mediated transport R-HSA-445717 8.510585e-01 0.070 0 0
FGFR1 mutant receptor activation R-HSA-1839124 8.520349e-01 0.070 0 0
Activation of ATR in response to replication stress R-HSA-176187 8.520349e-01 0.070 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.566076e-01 0.067 0 0
Mitochondrial protein import R-HSA-1268020 8.566076e-01 0.067 0 0
tRNA processing in the nucleus R-HSA-6784531 8.566076e-01 0.067 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.591182e-01 0.066 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.591182e-01 0.066 0 0
Base Excision Repair R-HSA-73884 8.624400e-01 0.064 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 8.640084e-01 0.063 0 0
Dual Incision in GG-NER R-HSA-5696400 8.658629e-01 0.063 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.658629e-01 0.063 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.658629e-01 0.063 0 0
Signaling by NOTCH2 R-HSA-1980145 8.658629e-01 0.063 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.658629e-01 0.063 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.658629e-01 0.063 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.672569e-01 0.062 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.718339e-01 0.060 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.722850e-01 0.059 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.722850e-01 0.059 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.754223e-01 0.058 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 8.755992e-01 0.058 0 0
Extracellular matrix organization R-HSA-1474244 8.763335e-01 0.057 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.769632e-01 0.057 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.784000e-01 0.056 0 0
RNA Polymerase III Transcription R-HSA-74158 8.784000e-01 0.056 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.784000e-01 0.056 0 0
HSF1 activation R-HSA-3371511 8.784000e-01 0.056 0 0
Glycosphingolipid transport R-HSA-9845576 8.784000e-01 0.056 0 0
Nicotinate metabolism R-HSA-196807 8.816183e-01 0.055 0 0
Rab regulation of trafficking R-HSA-9007101 8.828434e-01 0.054 0 0
Degradation of AXIN R-HSA-4641257 8.842226e-01 0.053 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.842226e-01 0.053 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.842226e-01 0.053 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.842226e-01 0.053 0 0
Ovarian tumor domain proteases R-HSA-5689896 8.842226e-01 0.053 0 0
Homology Directed Repair R-HSA-5693538 8.863261e-01 0.052 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.897668e-01 0.051 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 8.897668e-01 0.051 0 0
Elastic fibre formation R-HSA-1566948 8.897668e-01 0.051 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.897668e-01 0.051 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.950457e-01 0.048 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.000722e-01 0.046 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.000722e-01 0.046 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.000722e-01 0.046 0 0
Glycogen metabolism R-HSA-8982491 9.000722e-01 0.046 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.000722e-01 0.046 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.025422e-01 0.045 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 9.025422e-01 0.045 0 0
Phospholipid metabolism R-HSA-1483257 9.025763e-01 0.045 0 0
Maturation of spike protein R-HSA-9694548 9.048582e-01 0.043 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.048582e-01 0.043 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 9.048582e-01 0.043 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.048582e-01 0.043 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.051327e-01 0.043 0 0
Formation of the cornified envelope R-HSA-6809371 9.053813e-01 0.043 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.094153e-01 0.041 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.094153e-01 0.041 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.099025e-01 0.041 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.133844e-01 0.039 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.133844e-01 0.039 0 0
Signaling by NOTCH1 R-HSA-1980143 9.167397e-01 0.038 0 0
Defective pyroptosis R-HSA-9710421 9.178858e-01 0.037 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.183404e-01 0.037 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.199317e-01 0.036 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.218196e-01 0.035 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.218196e-01 0.035 0 0
RSV-host interactions R-HSA-9833110 9.226686e-01 0.035 1 0
Cholesterol biosynthesis R-HSA-191273 9.230872e-01 0.035 0 0
Interleukin-10 signaling R-HSA-6783783 9.230872e-01 0.035 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.255652e-01 0.034 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.255652e-01 0.034 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.255652e-01 0.034 0 0
Platelet homeostasis R-HSA-418346 9.278873e-01 0.033 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.291315e-01 0.032 0 0
Gene Silencing by RNA R-HSA-211000 9.303736e-01 0.031 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.325272e-01 0.030 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.325272e-01 0.030 0 0
Synthesis of PC R-HSA-1483191 9.325272e-01 0.030 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.325272e-01 0.030 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.344384e-01 0.029 0 0
NGF-stimulated transcription R-HSA-9031628 9.357604e-01 0.029 0 0
Gluconeogenesis R-HSA-70263 9.357604e-01 0.029 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.388388e-01 0.027 0 0
DNA Damage Bypass R-HSA-73893 9.388388e-01 0.027 0 0
PI3K Cascade R-HSA-109704 9.417699e-01 0.026 0 0
Complex IV assembly R-HSA-9864848 9.445607e-01 0.025 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.464035e-01 0.024 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.472179e-01 0.024 0 0
Orc1 removal from chromatin R-HSA-68949 9.472179e-01 0.024 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.472179e-01 0.024 0 0
SLC transporter disorders R-HSA-5619102 9.477480e-01 0.023 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.497479e-01 0.022 0 0
Nucleotide biosynthesis R-HSA-8956320 9.497479e-01 0.022 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.512350e-01 0.022 0 0
Downstream TCR signaling R-HSA-202424 9.544475e-01 0.020 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.544475e-01 0.020 0 0
Peptide hormone metabolism R-HSA-2980736 9.546369e-01 0.020 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.562376e-01 0.019 0 0
Co-inhibition by PD-1 R-HSA-389948 9.566328e-01 0.019 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 9.566340e-01 0.019 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.566340e-01 0.019 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.602800e-01 0.018 0 0
Dual incision in TC-NER R-HSA-6782135 9.606927e-01 0.017 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.607854e-01 0.017 0 0
FCGR activation R-HSA-2029481 9.613296e-01 0.017 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.625775e-01 0.017 0 0
Collagen formation R-HSA-1474290 9.628875e-01 0.016 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.643720e-01 0.016 0 0
RAB geranylgeranylation R-HSA-8873719 9.643720e-01 0.016 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.643720e-01 0.016 0 0
Endogenous sterols R-HSA-211976 9.660806e-01 0.015 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 9.677073e-01 0.014 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.698149e-01 0.013 0 0
Xenobiotics R-HSA-211981 9.707308e-01 0.013 0 0
ABC-family proteins mediated transport R-HSA-382556 9.722215e-01 0.012 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.744425e-01 0.011 0 0
Kidney development R-HSA-9830369 9.747441e-01 0.011 0 0
COPII-mediated vesicle transport R-HSA-204005 9.782078e-01 0.010 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.782078e-01 0.010 0 0
ECM proteoglycans R-HSA-3000178 9.792535e-01 0.009 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.792535e-01 0.009 0 0
Metabolism of cofactors R-HSA-8978934 9.792535e-01 0.009 0 0
Purine catabolism R-HSA-74259 9.802491e-01 0.009 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.802491e-01 0.009 0 0
Transport of small molecules R-HSA-382551 9.807941e-01 0.008 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.811969e-01 0.008 0 0
tRNA processing R-HSA-72306 9.826720e-01 0.008 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.827458e-01 0.008 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 9.829586e-01 0.007 0 0
ABC transporter disorders R-HSA-5619084 9.852967e-01 0.006 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.858272e-01 0.006 0 0
Interferon alpha/beta signaling R-HSA-909733 9.869828e-01 0.006 1 1
Visual phototransduction R-HSA-2187338 9.873359e-01 0.006 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.890556e-01 0.005 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.890556e-01 0.005 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.900816e-01 0.004 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.900816e-01 0.004 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.901610e-01 0.004 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.905580e-01 0.004 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.905580e-01 0.004 0 0
Pyruvate metabolism R-HSA-70268 9.910116e-01 0.004 0 0
HCMV Late Events R-HSA-9610379 9.914213e-01 0.004 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.914434e-01 0.004 0 0
Neddylation R-HSA-8951664 9.915755e-01 0.004 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.916366e-01 0.004 0 0
Neurotransmitter release cycle R-HSA-112310 9.922458e-01 0.003 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.924332e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.933107e-01 0.003 0 0
Mitochondrial protein degradation R-HSA-9837999 9.939382e-01 0.003 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.942494e-01 0.003 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.947709e-01 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.954894e-01 0.002 0 0
Keratinization R-HSA-6805567 9.954977e-01 0.002 0 0
Bacterial Infection Pathways R-HSA-9824439 9.957005e-01 0.002 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.961092e-01 0.002 0 0
Translation R-HSA-72766 9.968256e-01 0.001 0 0
Synthesis of DNA R-HSA-69239 9.971053e-01 0.001 0 0
Drug ADME R-HSA-9748784 9.971375e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.975033e-01 0.001 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.978055e-01 0.001 0 0
Metabolism of steroids R-HSA-8957322 9.978686e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.980217e-01 0.001 1 0
Metabolism of nucleotides R-HSA-15869 9.985667e-01 0.001 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.988088e-01 0.001 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.988088e-01 0.001 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.988718e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.989208e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.991568e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.991575e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.992729e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.993404e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.994167e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.994963e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.995397e-01 0.000 0 0
Complement cascade R-HSA-166658 9.996702e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.997424e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.997665e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.997667e-01 0.000 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.997689e-01 0.000 0 0
DNA Replication R-HSA-69306 9.997780e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999030e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999379e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999407e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999489e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999566e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999811e-01 0.000 1 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999931e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999989e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999995e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.940492e-14 13.306 0 0
Cell Cycle R-HSA-1640170 1.753153e-12 11.756 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.445488e-12 11.612 0 0
Cell Cycle, Mitotic R-HSA-69278 7.697287e-12 11.114 0 0
mRNA Splicing R-HSA-72172 1.258238e-11 10.900 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.306911e-11 10.200 0 0
M Phase R-HSA-68886 6.495551e-10 9.187 0 0
Metabolism of RNA R-HSA-8953854 3.155069e-09 8.501 0 0
Axon guidance R-HSA-422475 1.214549e-08 7.916 0 0
Cellular responses to stimuli R-HSA-8953897 3.326541e-08 7.478 0 0
Nervous system development R-HSA-9675108 5.117452e-08 7.291 0 0
Cellular responses to stress R-HSA-2262752 9.173367e-08 7.037 0 0
Apoptotic execution phase R-HSA-75153 1.326831e-07 6.877 0 0
Mitotic Prometaphase R-HSA-68877 1.452429e-07 6.838 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.165593e-07 6.380 0 0
Chromatin modifying enzymes R-HSA-3247509 5.296046e-07 6.276 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 6.855111e-07 6.164 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.251154e-06 5.903 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.300878e-06 5.886 0 0
Signaling by ALK in cancer R-HSA-9700206 1.300878e-06 5.886 0 0
Cellular response to heat stress R-HSA-3371556 1.396855e-06 5.855 0 0
Chromatin organization R-HSA-4839726 2.359475e-06 5.627 0 0
Cell-Cell communication R-HSA-1500931 3.878328e-06 5.411 0 0
mRNA 3'-end processing R-HSA-72187 8.764097e-06 5.057 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.116447e-05 4.952 0 0
Mitotic Prophase R-HSA-68875 1.151030e-05 4.939 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.742821e-05 4.759 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.742821e-05 4.759 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.801429e-05 4.744 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.129903e-05 4.672 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.438900e-05 4.613 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.438900e-05 4.613 0 0
HATs acetylate histones R-HSA-3214847 2.588875e-05 4.587 0 0
Kinesins R-HSA-983189 2.878233e-05 4.541 0 0
Attenuation phase R-HSA-3371568 3.211265e-05 4.493 0 0
Mitotic Anaphase R-HSA-68882 3.359792e-05 4.474 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.459975e-05 4.461 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.691188e-05 4.433 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.805353e-05 4.420 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.576353e-05 4.339 1 0
Cell junction organization R-HSA-446728 4.530867e-05 4.344 0 0
ESR-mediated signaling R-HSA-8939211 4.758435e-05 4.323 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.057523e-05 4.296 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.966888e-05 4.304 0 0
Signaling by ERBB2 R-HSA-1227986 7.160721e-05 4.145 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.176817e-05 4.144 0 0
Striated Muscle Contraction R-HSA-390522 8.884337e-05 4.051 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 9.079021e-05 4.042 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 9.435559e-05 4.025 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.011957e-04 3.995 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.126901e-04 3.948 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.234877e-04 3.908 0 0
HSF1-dependent transactivation R-HSA-3371571 1.228363e-04 3.911 0 0
HDACs deacetylate histones R-HSA-3214815 1.307647e-04 3.884 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.423611e-04 3.847 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.423611e-04 3.847 0 0
Apoptosis R-HSA-109581 1.390646e-04 3.857 0 0
Separation of Sister Chromatids R-HSA-2467813 1.806093e-04 3.743 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.893567e-04 3.723 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.132053e-04 3.671 0 0
Meiotic synapsis R-HSA-1221632 1.990501e-04 3.701 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.078675e-04 3.682 0 0
HSF1 activation R-HSA-3371511 2.190715e-04 3.659 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.169065e-04 3.664 0 0
Deubiquitination R-HSA-5688426 2.061264e-04 3.686 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.191568e-04 3.659 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.197437e-04 3.658 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.436449e-04 3.613 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.432927e-04 3.614 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.758339e-04 3.559 0 0
Membrane Trafficking R-HSA-199991 2.780306e-04 3.556 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.531630e-04 3.452 0 0
Cell-cell junction organization R-HSA-421270 3.564806e-04 3.448 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.826499e-04 3.417 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.844878e-04 3.415 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.989394e-04 3.399 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.033483e-04 3.394 0 0
PKR-mediated signaling R-HSA-9833482 3.906016e-04 3.408 1 1
Cell Cycle Checkpoints R-HSA-69620 4.443999e-04 3.352 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.560169e-04 3.341 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.750494e-04 3.323 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.846129e-04 3.315 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.141980e-04 3.289 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.141980e-04 3.289 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.066904e-04 3.295 0 0
Signaling by Hippo R-HSA-2028269 5.141980e-04 3.289 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.531595e-04 3.257 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.531595e-04 3.257 0 0
G2/M Transition R-HSA-69275 5.541853e-04 3.256 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.722848e-04 3.242 0 0
Ribosome-associated quality control R-HSA-9948299 5.608041e-04 3.251 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.972895e-04 3.224 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.977243e-04 3.223 0 0
Programmed Cell Death R-HSA-5357801 6.428865e-04 3.192 0 0
Recycling pathway of L1 R-HSA-437239 6.981348e-04 3.156 0 0
Centrosome maturation R-HSA-380287 6.979758e-04 3.156 0 0
L1CAM interactions R-HSA-373760 6.976414e-04 3.156 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 7.168919e-04 3.145 0 0
Signaling by PTK6 R-HSA-8848021 7.298103e-04 3.137 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 7.298103e-04 3.137 0 0
Intracellular signaling by second messengers R-HSA-9006925 7.839438e-04 3.106 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.534666e-04 3.069 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.134339e-04 3.039 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.513996e-04 3.022 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.614374e-04 3.017 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.113894e-03 2.953 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.241268e-03 2.906 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.171359e-03 2.931 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.238318e-03 2.907 0 0
Signaling by ROBO receptors R-HSA-376176 1.237206e-03 2.908 0 0
Signaling by RAS mutants R-HSA-6802949 1.315142e-03 2.881 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.315142e-03 2.881 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.315142e-03 2.881 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.315142e-03 2.881 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.321721e-03 2.879 0 0
Translation initiation complex formation R-HSA-72649 1.331082e-03 2.876 0 0
Signaling by VEGF R-HSA-194138 1.451594e-03 2.838 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.474725e-03 2.831 0 0
Post NMDA receptor activation events R-HSA-438064 1.485616e-03 2.828 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.644690e-03 2.784 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.742620e-03 2.759 0 0
Regulation of TP53 Activity R-HSA-5633007 1.685861e-03 2.773 0 0
Interleukin-12 signaling R-HSA-9020591 1.690126e-03 2.772 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.681565e-03 2.774 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.881769e-03 2.725 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.917081e-03 2.717 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.061280e-03 2.686 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.077377e-03 2.682 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.077377e-03 2.682 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.111792e-03 2.675 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 2.174496e-03 2.663 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.296509e-03 2.639 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.197443e-03 2.658 0 0
Adherens junctions interactions R-HSA-418990 2.277068e-03 2.643 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.321699e-03 2.634 0 0
RNA Polymerase I Transcription R-HSA-73864 2.324751e-03 2.634 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.421480e-03 2.616 0 0
Rab regulation of trafficking R-HSA-9007101 2.563930e-03 2.591 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 2.678014e-03 2.572 0 0
Ub-specific processing proteases R-HSA-5689880 2.717827e-03 2.566 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.727010e-03 2.564 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.894111e-03 2.538 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.164961e-03 2.500 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.152459e-03 2.501 0 0
Influenza Infection R-HSA-168255 3.069283e-03 2.513 1 0
ChREBP activates metabolic gene expression R-HSA-163765 3.177882e-03 2.498 0 0
Peptide chain elongation R-HSA-156902 3.264398e-03 2.486 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.316986e-03 2.479 0 0
Signaling by Erythropoietin R-HSA-9006335 3.364960e-03 2.473 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 3.522549e-03 2.453 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.522549e-03 2.453 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.797800e-03 2.420 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.314128e-03 2.365 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 4.429553e-03 2.354 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.477123e-03 2.349 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.108957e-03 2.386 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.284852e-03 2.368 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.477123e-03 2.349 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.431572e-03 2.353 0 0
FLT3 Signaling R-HSA-9607240 4.477655e-03 2.349 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.540652e-03 2.343 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.564679e-03 2.341 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.586545e-03 2.339 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.212947e-03 2.283 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.212947e-03 2.283 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.212947e-03 2.283 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.212947e-03 2.283 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.212947e-03 2.283 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.212947e-03 2.283 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.212947e-03 2.283 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.212947e-03 2.283 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.212947e-03 2.283 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.212947e-03 2.283 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.212947e-03 2.283 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.039510e-03 2.298 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 5.210981e-03 2.283 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.892440e-03 2.310 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.957361e-03 2.305 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.109779e-03 2.292 0 0
MHC class II antigen presentation R-HSA-2132295 5.159815e-03 2.287 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.177527e-03 2.286 0 0
Interleukin-12 family signaling R-HSA-447115 5.232548e-03 2.281 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.240244e-03 2.281 0 0
Downstream signal transduction R-HSA-186763 5.398716e-03 2.268 0 0
RAF activation R-HSA-5673000 5.489523e-03 2.260 0 0
Signaling by RAF1 mutants R-HSA-9656223 5.448570e-03 2.264 0 0
Nucleosome assembly R-HSA-774815 5.348699e-03 2.272 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.348699e-03 2.272 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.854836e-03 2.232 0 0
Nuclear import of Rev protein R-HSA-180746 5.489523e-03 2.260 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.767429e-03 2.239 0 0
DNA Repair R-HSA-73894 5.862563e-03 2.232 0 0
Cellular Senescence R-HSA-2559583 5.280400e-03 2.277 0 0
G2/M Checkpoints R-HSA-69481 5.351745e-03 2.272 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.984154e-03 2.223 0 0
Erythropoietin activates RAS R-HSA-9027284 6.056609e-03 2.218 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 6.056609e-03 2.218 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 6.056609e-03 2.218 0 0
UCH proteinases R-HSA-5689603 6.288035e-03 2.201 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.320158e-03 2.199 0 0
Meiosis R-HSA-1500620 6.369983e-03 2.196 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.705445e-03 2.174 0 0
snRNP Assembly R-HSA-191859 6.735855e-03 2.172 0 0
Metabolism of non-coding RNA R-HSA-194441 6.735855e-03 2.172 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.868988e-03 2.163 1 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 6.909606e-03 2.161 0 0
Transport of connexons to the plasma membrane R-HSA-190872 7.005862e-03 2.155 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.054737e-03 2.152 0 0
SOS-mediated signalling R-HSA-112412 8.010710e-03 2.096 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 8.010710e-03 2.096 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.058420e-03 2.094 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 8.114537e-03 2.091 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.114537e-03 2.091 0 0
MECP2 regulates transcription factors R-HSA-9022707 8.010710e-03 2.096 0 0
Signaling by SCF-KIT R-HSA-1433557 7.904391e-03 2.102 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.645864e-03 2.117 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.114537e-03 2.091 0 0
Signaling by EGFR R-HSA-177929 8.276769e-03 2.082 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 8.321186e-03 2.080 0 0
Signaling by FGFR in disease R-HSA-1226099 8.818961e-03 2.055 0 0
Regulation of signaling by CBL R-HSA-912631 9.245414e-03 2.034 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.389271e-03 2.027 0 0
RMTs methylate histone arginines R-HSA-3214858 9.428920e-03 2.026 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.462264e-03 2.024 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.008903e-02 1.996 1 1
Signaling by EGFR in Cancer R-HSA-1643713 1.014990e-02 1.994 0 0
Metalloprotease DUBs R-HSA-5689901 1.014990e-02 1.994 0 0
Smooth Muscle Contraction R-HSA-445355 1.017921e-02 1.992 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.018999e-02 1.992 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.024967e-02 1.989 0 0
Eukaryotic Translation Termination R-HSA-72764 1.032404e-02 1.986 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.039256e-02 1.983 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.042990e-02 1.982 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.199467e-02 1.921 0 0
MAP2K and MAPK activation R-HSA-5674135 1.163805e-02 1.934 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.179654e-02 1.928 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.152999e-02 1.938 0 0
Formation of definitive endoderm R-HSA-9823730 1.199467e-02 1.921 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.074656e-02 1.969 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.166399e-02 1.933 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.189604e-02 1.925 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.059971e-02 1.975 0 0
Gene expression (Transcription) R-HSA-74160 1.113721e-02 1.953 0 0
Nephrin family interactions R-HSA-373753 1.199467e-02 1.921 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.214890e-02 1.915 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.230492e-02 1.910 0 0
Formation of annular gap junctions R-HSA-196025 1.233435e-02 1.909 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.246835e-02 1.904 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.258614e-02 1.900 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.258614e-02 1.900 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.282801e-02 1.892 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.282801e-02 1.892 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.311193e-02 1.882 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.317648e-02 1.880 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.317648e-02 1.880 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.326694e-02 1.877 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.341040e-02 1.873 0 0
Signal Transduction R-HSA-162582 1.358034e-02 1.867 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.380117e-02 1.860 0 0
SARS-CoV-1-host interactions R-HSA-9692914 1.382604e-02 1.859 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.427231e-02 1.846 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.438528e-02 1.842 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.438528e-02 1.842 1 0
Signaling by ALK R-HSA-201556 1.438528e-02 1.842 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.459560e-02 1.836 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.497862e-02 1.825 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 1.518263e-02 1.819 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 1.518263e-02 1.819 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 1.518263e-02 1.819 0 0
Gap junction degradation R-HSA-190873 1.807970e-02 1.743 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.564953e-02 1.805 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.556941e-02 1.808 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.780980e-02 1.749 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.780980e-02 1.749 0 0
Neutrophil degranulation R-HSA-6798695 1.788609e-02 1.747 0 0
Aggrephagy R-HSA-9646399 1.706296e-02 1.768 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.707300e-02 1.768 0 0
Unwinding of DNA R-HSA-176974 1.807970e-02 1.743 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.769900e-02 1.752 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.800254e-02 1.745 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.789899e-02 1.747 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.706296e-02 1.768 0 0
Glycolysis R-HSA-70171 1.789899e-02 1.747 0 0
Diseases of programmed cell death R-HSA-9645723 1.815807e-02 1.741 0 0
G1/S Transition R-HSA-69206 1.826903e-02 1.738 0 0
Regulation of CDH1 Function R-HSA-9764561 1.836347e-02 1.736 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.846847e-02 1.734 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 1.882009e-02 1.725 0 0
DNA methylation R-HSA-5334118 1.898706e-02 1.722 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.928496e-02 1.715 0 0
Tight junction interactions R-HSA-420029 1.929307e-02 1.715 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.941806e-02 1.712 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.964211e-02 1.707 0 0
Selenocysteine synthesis R-HSA-2408557 1.984364e-02 1.702 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.005814e-02 1.698 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.027469e-02 1.693 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.027469e-02 1.693 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.133287e-02 1.671 0 0
Muscle contraction R-HSA-397014 2.206602e-02 1.656 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.209041e-02 1.656 0 0
Semaphorin interactions R-HSA-373755 2.235990e-02 1.651 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.269858e-02 1.644 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.269858e-02 1.644 0 0
MAPK family signaling cascades R-HSA-5683057 2.292833e-02 1.640 0 0
Signaling by Interleukins R-HSA-449147 2.485826e-02 1.605 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.489519e-02 1.604 0 0
Regulation of CDH11 function R-HSA-9762292 2.543127e-02 1.595 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.543127e-02 1.595 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.543127e-02 1.595 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.648644e-02 1.577 0 0
Diseases of Cellular Senescence R-HSA-9630747 3.180687e-02 1.497 0 0
Diseases of cellular response to stress R-HSA-9675132 3.180687e-02 1.497 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.180687e-02 1.497 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.180687e-02 1.497 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.830898e-02 1.548 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.957446e-02 1.529 0 0
Interaction between L1 and Ankyrins R-HSA-445095 2.855120e-02 1.544 0 0
Packaging Of Telomere Ends R-HSA-171306 2.855120e-02 1.544 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.160983e-02 1.500 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.984589e-02 1.525 0 0
Protein folding R-HSA-391251 3.075987e-02 1.512 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.131011e-02 1.504 0 0
Nucleotide Excision Repair R-HSA-5696398 3.218207e-02 1.492 0 0
MTOR signalling R-HSA-165159 2.740574e-02 1.562 0 0
G0 and Early G1 R-HSA-1538133 3.259588e-02 1.487 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.088891e-02 1.510 0 0
TBC/RABGAPs R-HSA-8854214 3.171649e-02 1.499 0 0
HIV Life Cycle R-HSA-162587 2.859716e-02 1.544 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.209942e-02 1.494 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.855120e-02 1.544 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 3.296694e-02 1.482 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.296694e-02 1.482 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 3.296694e-02 1.482 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 3.296694e-02 1.482 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.302651e-02 1.481 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.318174e-02 1.479 0 0
IRS-mediated signalling R-HSA-112399 3.334526e-02 1.477 0 0
Interleukin-2 family signaling R-HSA-451927 3.388395e-02 1.470 0 0
Co-stimulation by CD28 R-HSA-389356 3.398279e-02 1.469 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.486516e-02 1.458 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.564074e-02 1.448 0 0
Potential therapeutics for SARS R-HSA-9679191 3.596148e-02 1.444 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.596148e-02 1.444 0 0
RET signaling R-HSA-8853659 3.611871e-02 1.442 0 0
Gap junction trafficking R-HSA-190828 3.650315e-02 1.438 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 3.668541e-02 1.436 0 0
Cilium Assembly R-HSA-5617833 3.678820e-02 1.434 0 0
Viral mRNA Translation R-HSA-192823 3.818931e-02 1.418 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.838611e-02 1.416 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.838611e-02 1.416 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.838611e-02 1.416 0 0
Gene Silencing by RNA R-HSA-211000 3.849626e-02 1.415 0 0
Gap junction trafficking and regulation R-HSA-157858 3.877616e-02 1.411 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.916657e-02 1.407 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.916657e-02 1.407 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.918045e-02 1.407 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 4.629271e-02 1.334 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 4.629271e-02 1.334 0 0
Diseases of Telomere Maintenance R-HSA-9673013 4.629271e-02 1.334 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 4.629271e-02 1.334 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 4.629271e-02 1.334 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 4.629271e-02 1.334 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 4.940686e-02 1.306 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 4.940686e-02 1.306 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.176175e-02 1.379 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.176175e-02 1.379 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.552757e-02 1.342 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.552757e-02 1.342 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.654814e-02 1.332 0 0
Ephrin signaling R-HSA-3928664 4.602988e-02 1.337 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 4.602988e-02 1.337 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.463931e-02 1.350 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.463931e-02 1.350 0 0
Long-term potentiation R-HSA-9620244 4.276225e-02 1.369 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 4.063032e-02 1.391 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.783230e-02 1.320 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.486381e-02 1.348 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.395165e-02 1.357 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.063032e-02 1.391 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.771792e-02 1.321 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.242840e-02 1.372 0 0
Platelet sensitization by LDL R-HSA-432142 4.602988e-02 1.337 0 0
Integration of provirus R-HSA-162592 4.552757e-02 1.342 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 4.940686e-02 1.306 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 4.940686e-02 1.306 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 4.196127e-02 1.377 0 0
Interferon Signaling R-HSA-913531 4.959611e-02 1.305 1 0
S Phase R-HSA-69242 4.492515e-02 1.348 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 4.940686e-02 1.306 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.276225e-02 1.369 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.501068e-02 1.347 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 4.940686e-02 1.306 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.654814e-02 1.332 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.654814e-02 1.332 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.501068e-02 1.347 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.063032e-02 1.391 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.613710e-02 1.336 0 0
Activation of BH3-only proteins R-HSA-114452 4.783230e-02 1.320 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.552757e-02 1.342 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 4.463931e-02 1.350 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 4.046679e-02 1.393 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.156846e-02 1.381 0 0
Organelle biogenesis and maintenance R-HSA-1852241 4.986811e-02 1.302 0 0
Myogenesis R-HSA-525793 5.079509e-02 1.294 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.144030e-02 1.289 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.163190e-02 1.287 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.205965e-02 1.283 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.317146e-02 1.274 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.317146e-02 1.274 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.329079e-02 1.273 0 0
mTORC1-mediated signalling R-HSA-166208 5.363152e-02 1.271 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 5.363152e-02 1.271 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.363152e-02 1.271 0 0
Autophagy R-HSA-9612973 5.484857e-02 1.261 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.497059e-02 1.260 0 0
Inhibition of nitric oxide production R-HSA-9636249 5.497059e-02 1.260 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 5.549477e-02 1.256 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.557097e-02 1.255 0 0
HIV Infection R-HSA-162906 5.573968e-02 1.254 0 0
Orc1 removal from chromatin R-HSA-68949 5.604808e-02 1.251 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.613730e-02 1.251 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.643978e-02 1.248 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 5.643978e-02 1.248 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.643978e-02 1.248 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.643978e-02 1.248 0 0
Calcineurin activates NFAT R-HSA-2025928 5.643978e-02 1.248 0 0
ALK mutants bind TKIs R-HSA-9700645 5.643978e-02 1.248 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 5.643978e-02 1.248 0 0
RNA Polymerase II Transcription R-HSA-73857 5.718764e-02 1.243 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.846227e-02 1.233 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.846227e-02 1.233 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.846227e-02 1.233 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.846227e-02 1.233 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.846227e-02 1.233 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.846227e-02 1.233 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.846227e-02 1.233 0 0
Signaling by FGFR4 R-HSA-5654743 5.847659e-02 1.233 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.977402e-02 1.223 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.977402e-02 1.223 0 0
Viral Infection Pathways R-HSA-9824446 5.978758e-02 1.223 1 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.999976e-02 1.222 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.048973e-02 1.218 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.086983e-02 1.216 0 0
Chromosome Maintenance R-HSA-73886 6.241447e-02 1.205 0 0
DNA Replication R-HSA-69306 6.318102e-02 1.199 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.319330e-02 1.199 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.372757e-02 1.196 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.472438e-02 1.189 0 0
PTEN Regulation R-HSA-6807070 6.504069e-02 1.187 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 6.669589e-02 1.176 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.755297e-02 1.170 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.755297e-02 1.170 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.870527e-02 1.163 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.959093e-02 1.157 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.959093e-02 1.157 0 0
Neurofascin interactions R-HSA-447043 6.959093e-02 1.157 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.959093e-02 1.157 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.959093e-02 1.157 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 8.415659e-02 1.075 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 8.415659e-02 1.075 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 9.336047e-02 1.030 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 9.336047e-02 1.030 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 7.372274e-02 1.132 0 0
2-LTR circle formation R-HSA-164843 7.372274e-02 1.132 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 7.337827e-02 1.134 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 8.731602e-02 1.059 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 8.731602e-02 1.059 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.066594e-02 1.093 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.189563e-02 1.143 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 8.338841e-02 1.079 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.766965e-02 1.057 0 0
HCMV Early Events R-HSA-9609690 7.268363e-02 1.139 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 9.279566e-02 1.032 0 0
Co-inhibition by PD-1 R-HSA-389948 9.027250e-02 1.044 0 0
Signaling by FGFR1 R-HSA-5654736 8.642803e-02 1.063 0 0
EPH-Ephrin signaling R-HSA-2682334 7.475022e-02 1.126 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.260372e-02 1.033 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.070087e-02 1.093 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 7.446097e-02 1.128 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 7.819193e-02 1.107 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 9.336047e-02 1.030 0 0
PI3K/AKT activation R-HSA-198203 7.372274e-02 1.132 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.644537e-02 1.117 0 0
IGF1R signaling cascade R-HSA-2428924 7.264887e-02 1.139 0 0
Regulation of KIT signaling R-HSA-1433559 9.026588e-02 1.044 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.008265e-02 1.096 0 0
Signaling by WNT R-HSA-195721 7.977350e-02 1.098 0 0
NADE modulates death signalling R-HSA-205025 8.415659e-02 1.075 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 8.070087e-02 1.093 0 0
Selective autophagy R-HSA-9663891 7.478931e-02 1.126 0 0
HDMs demethylate histones R-HSA-3214842 8.731602e-02 1.059 0 0
Macroautophagy R-HSA-1632852 7.429774e-02 1.129 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.644537e-02 1.117 0 0
Insulin receptor signalling cascade R-HSA-74751 7.264887e-02 1.139 0 0
Meiotic recombination R-HSA-912446 8.512741e-02 1.070 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.446097e-02 1.128 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 8.415659e-02 1.075 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.446097e-02 1.128 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.029666e-02 1.095 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.338841e-02 1.079 0 0
RAB geranylgeranylation R-HSA-8873719 7.920152e-02 1.101 0 0
Interleukin-37 signaling R-HSA-9008059 9.260372e-02 1.033 0 0
Inositol phosphate metabolism R-HSA-1483249 8.523262e-02 1.069 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 8.642803e-02 1.063 0 0
NRAGE signals death through JNK R-HSA-193648 8.642803e-02 1.063 0 0
SARS-CoV Infections R-HSA-9679506 8.466978e-02 1.072 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.254541e-02 1.139 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.642803e-02 1.063 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 9.337980e-02 1.030 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 9.337980e-02 1.030 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 9.337980e-02 1.030 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 9.337980e-02 1.030 0 0
Manipulation of host energy metabolism R-HSA-9636667 9.337980e-02 1.030 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 9.337980e-02 1.030 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 9.337980e-02 1.030 0 0
Breakdown of the nuclear lamina R-HSA-352238 9.337980e-02 1.030 0 0
Signaling by APC mutants R-HSA-4839744 9.355804e-02 1.029 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 9.355804e-02 1.029 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 9.355804e-02 1.029 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 9.355804e-02 1.029 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 9.355804e-02 1.029 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 9.395120e-02 1.027 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.437047e-02 1.025 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.437047e-02 1.025 0 0
rRNA processing R-HSA-72312 9.498914e-02 1.022 0 0
Heme signaling R-HSA-9707616 9.605211e-02 1.017 0 0
tRNA processing in the nucleus R-HSA-6784531 9.605211e-02 1.017 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.605211e-02 1.017 0 0
DNA Double Strand Break Response R-HSA-5693606 9.640676e-02 1.016 0 0
Glucose metabolism R-HSA-70326 9.688347e-02 1.014 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.798905e-02 1.009 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.000904e-01 1.000 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.000904e-01 1.000 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.008193e-01 0.996 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.017143e-01 0.993 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.017143e-01 0.993 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.017143e-01 0.993 0 0
Tie2 Signaling R-HSA-210993 1.017143e-01 0.993 0 0
Defective pyroptosis R-HSA-9710421 1.017170e-01 0.993 0 0
Homology Directed Repair R-HSA-5693538 1.035143e-01 0.985 0 0
Developmental Biology R-HSA-1266738 1.042291e-01 0.982 0 0
Translation R-HSA-72766 1.043516e-01 0.982 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.051223e-01 0.978 0 0
Vesicle-mediated transport R-HSA-5653656 1.071353e-01 0.970 0 0
Host Interactions of HIV factors R-HSA-162909 1.089211e-01 0.963 0 0
Signalling to ERKs R-HSA-187687 1.089639e-01 0.963 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.089639e-01 0.963 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.090759e-01 0.962 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.090759e-01 0.962 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.090759e-01 0.962 0 0
Protein methylation R-HSA-8876725 1.090759e-01 0.962 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.090759e-01 0.962 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.090759e-01 0.962 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.097590e-01 0.960 0 0
Signaling by KIT in disease R-HSA-9669938 1.097590e-01 0.960 0 0
Cellular response to chemical stress R-HSA-9711123 1.122384e-01 0.950 0 0
Sensory processing of sound R-HSA-9659379 1.135118e-01 0.945 0 0
Signaling by ERBB4 R-HSA-1236394 1.141862e-01 0.942 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.154480e-01 0.938 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.154480e-01 0.938 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.154480e-01 0.938 0 0
Activation of RAC1 R-HSA-428540 1.158278e-01 0.936 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.158278e-01 0.936 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 1.158278e-01 0.936 0 0
Signaling by AXIN mutants R-HSA-4839735 1.158278e-01 0.936 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.158278e-01 0.936 0 0
Telomere Maintenance R-HSA-157579 1.177211e-01 0.929 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.177211e-01 0.929 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.177211e-01 0.929 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.185469e-01 0.926 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.185469e-01 0.926 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.185469e-01 0.926 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 1.194224e-01 0.923 0 0
E2F mediated regulation of DNA replication R-HSA-113510 1.194224e-01 0.923 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.194224e-01 0.923 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.194534e-01 0.923 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.194534e-01 0.923 0 0
FGFR1b ligand binding and activation R-HSA-190370 1.204343e-01 0.919 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.204343e-01 0.919 0 0
Activation of RAS in B cells R-HSA-1169092 1.204343e-01 0.919 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.215812e-01 0.915 0 0
G1/S-Specific Transcription R-HSA-69205 1.222225e-01 0.913 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.222225e-01 0.913 0 0
RNA Polymerase III Transcription R-HSA-74158 1.222225e-01 0.913 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.240633e-01 0.906 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.240633e-01 0.906 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.240633e-01 0.906 0 0
DAG and IP3 signaling R-HSA-1489509 1.251946e-01 0.902 0 0
Signaling by FGFR3 R-HSA-5654741 1.251946e-01 0.902 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.251946e-01 0.902 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.251946e-01 0.902 0 0
PI3K Cascade R-HSA-109704 1.257755e-01 0.900 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.264298e-01 0.898 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.297231e-01 0.887 0 0
Prolonged ERK activation events R-HSA-169893 1.297231e-01 0.887 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.564701e-01 0.806 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.564701e-01 0.806 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.564701e-01 0.806 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 1.564701e-01 0.806 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.564701e-01 0.806 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.564701e-01 0.806 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.564701e-01 0.806 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.564701e-01 0.806 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.564701e-01 0.806 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.564701e-01 0.806 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 1.564701e-01 0.806 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.564701e-01 0.806 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.564701e-01 0.806 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.564701e-01 0.806 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.564701e-01 0.806 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.564701e-01 0.806 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.564701e-01 0.806 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.564701e-01 0.806 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.564701e-01 0.806 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.564701e-01 0.806 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.564701e-01 0.806 0 0
Regulation of TP53 Expression R-HSA-6804754 1.490829e-01 0.827 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.490829e-01 0.827 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 1.490829e-01 0.827 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 1.490829e-01 0.827 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.571767e-01 0.804 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.571767e-01 0.804 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 1.571767e-01 0.804 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.504414e-01 0.823 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.403591e-01 0.853 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.403591e-01 0.853 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.403591e-01 0.853 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.829515e-01 0.738 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.829515e-01 0.738 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.669347e-01 0.777 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.386059e-01 0.858 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.953045e-01 0.709 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.953045e-01 0.709 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.953045e-01 0.709 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 1.760347e-01 0.754 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.591809e-01 0.798 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 1.443347e-01 0.841 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.810453e-01 0.742 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 1.810453e-01 0.742 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 1.634107e-01 0.787 0 0
DARPP-32 events R-HSA-180024 1.479665e-01 0.830 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.668530e-01 0.778 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 1.844090e-01 0.734 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.508643e-01 0.821 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.643403e-01 0.784 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.457915e-01 0.836 0 0
Signaling by FGFR2 R-HSA-5654738 1.780866e-01 0.749 0 0
Cellular response to starvation R-HSA-9711097 1.537543e-01 0.813 0 0
Signaling by FGFR R-HSA-190236 1.766067e-01 0.753 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.405694e-01 0.852 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.403591e-01 0.853 0 0
Activation of the pre-replicative complex R-HSA-68962 1.657701e-01 0.780 0 0
G alpha (12/13) signalling events R-HSA-416482 1.550168e-01 0.810 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.559927e-01 0.807 0 0
Repression of WNT target genes R-HSA-4641265 1.403591e-01 0.853 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.821761e-01 0.740 0 0
DAP12 signaling R-HSA-2424491 1.657701e-01 0.780 0 0
Generation of second messenger molecules R-HSA-202433 1.835525e-01 0.736 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.520905e-01 0.818 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.835820e-01 0.736 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.688941e-01 0.772 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.329299e-01 0.876 0 0
Interleukin-6 signaling R-HSA-1059683 1.669347e-01 0.777 0 0
Neurexins and neuroligins R-HSA-6794361 1.508643e-01 0.821 0 0
Signaling by NTRKs R-HSA-166520 1.597429e-01 0.797 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.701007e-01 0.769 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.546732e-01 0.811 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.835525e-01 0.736 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.835525e-01 0.736 0 0
Oncogene Induced Senescence R-HSA-2559585 1.844090e-01 0.734 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.403591e-01 0.853 0 0
Disorders of Developmental Biology R-HSA-9675151 1.520905e-01 0.818 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.669347e-01 0.777 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.835820e-01 0.736 0 0
PI Metabolism R-HSA-1483255 1.632174e-01 0.787 0 0
Gap junction assembly R-HSA-190861 1.668530e-01 0.778 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 1.403591e-01 0.853 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.637576e-01 0.786 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 1.490829e-01 0.827 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.490829e-01 0.827 0 0
Uptake and function of anthrax toxins R-HSA-5210891 1.760347e-01 0.754 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.409797e-01 0.851 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.669347e-01 0.777 0 0
Neurodegenerative Diseases R-HSA-8863678 1.443347e-01 0.841 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.443347e-01 0.841 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.810453e-01 0.742 0 0
Reproduction R-HSA-1474165 1.726270e-01 0.763 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.504414e-01 0.823 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.520905e-01 0.818 0 0
Cleavage of the damaged purine R-HSA-110331 1.363379e-01 0.865 0 0
Depurination R-HSA-73927 1.512863e-01 0.820 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.516667e-01 0.819 0 0
Depyrimidination R-HSA-73928 1.516667e-01 0.819 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.973741e-01 0.705 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.987403e-01 0.702 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.988340e-01 0.702 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 1.990401e-01 0.701 0 0
Signaling by LTK in cancer R-HSA-9842640 1.990401e-01 0.701 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.990401e-01 0.701 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 2.007904e-01 0.697 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.007904e-01 0.697 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.013905e-01 0.696 0 0
CaM pathway R-HSA-111997 2.027604e-01 0.693 0 0
Calmodulin induced events R-HSA-111933 2.027604e-01 0.693 0 0
GPVI-mediated activation cascade R-HSA-114604 2.027604e-01 0.693 0 0
FLT3 signaling in disease R-HSA-9682385 2.027604e-01 0.693 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.028109e-01 0.693 0 0
Selenoamino acid metabolism R-HSA-2408522 2.034902e-01 0.691 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 2.040822e-01 0.690 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 2.040822e-01 0.690 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.040822e-01 0.690 0 0
DNA strand elongation R-HSA-69190 2.041748e-01 0.690 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.041748e-01 0.690 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.047613e-01 0.689 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.047613e-01 0.689 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.047613e-01 0.689 0 0
IRE1alpha activates chaperones R-HSA-381070 2.069311e-01 0.684 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 2.095549e-01 0.679 0 0
TRKA activation by NGF R-HSA-187042 2.095549e-01 0.679 0 0
PLC-gamma1 signalling R-HSA-167021 2.095549e-01 0.679 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.095549e-01 0.679 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 2.095549e-01 0.679 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 2.095549e-01 0.679 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 2.095549e-01 0.679 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 2.095549e-01 0.679 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 2.095549e-01 0.679 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.100537e-01 0.678 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.116733e-01 0.674 0 0
Death Receptor Signaling R-HSA-73887 2.122182e-01 0.673 0 0
PECAM1 interactions R-HSA-210990 2.175018e-01 0.663 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 2.175018e-01 0.663 0 0
Interleukin-2 signaling R-HSA-9020558 2.175018e-01 0.663 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 2.175018e-01 0.663 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 2.175018e-01 0.663 0 0
Signaling by PDGF R-HSA-186797 2.195607e-01 0.658 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.884648e-01 0.540 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 2.884648e-01 0.540 0 0
Defective Mismatch Repair Associated With MSH3 R-HSA-5632927 2.884648e-01 0.540 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.884648e-01 0.540 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 2.884648e-01 0.540 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.884648e-01 0.540 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.884648e-01 0.540 0 0
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) R-HSA-5619110 2.884648e-01 0.540 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.884648e-01 0.540 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.884648e-01 0.540 0 0
Defective GALM causes GALAC4 R-HSA-9931929 2.884648e-01 0.540 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.884648e-01 0.540 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.884648e-01 0.540 0 0
Defective F8 binding to von Willebrand factor R-HSA-9672393 2.884648e-01 0.540 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.884648e-01 0.540 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.719409e-01 0.566 0 0
Regulation of gap junction activity R-HSA-191650 2.719409e-01 0.566 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.719409e-01 0.566 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 2.719409e-01 0.566 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.719409e-01 0.566 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.719409e-01 0.566 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.719409e-01 0.566 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.719409e-01 0.566 0 0
FGFR4 mutant receptor activation R-HSA-1839128 3.998115e-01 0.398 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 3.998115e-01 0.398 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 3.998115e-01 0.398 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.998115e-01 0.398 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 3.998115e-01 0.398 0 0
Defective VWF binding to collagen type I R-HSA-9845622 3.998115e-01 0.398 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.998115e-01 0.398 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.998115e-01 0.398 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.998115e-01 0.398 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.998115e-01 0.398 0 0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) R-HSA-5619045 3.998115e-01 0.398 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.998115e-01 0.398 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.998115e-01 0.398 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.998115e-01 0.398 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 3.998115e-01 0.398 0 0
Defective APRT disrupts adenine salvage R-HSA-9734195 3.998115e-01 0.398 0 0
Defective SLC34A2 causes PALM R-HSA-5687583 3.998115e-01 0.398 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.998115e-01 0.398 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.998115e-01 0.398 0 0
Activation of TRKA receptors R-HSA-187015 2.431605e-01 0.614 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.431605e-01 0.614 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.431605e-01 0.614 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 2.431605e-01 0.614 0 0
Disinhibition of SNARE formation R-HSA-114516 2.431605e-01 0.614 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 3.341623e-01 0.476 0 0
Activation of AKT2 R-HSA-165158 3.341623e-01 0.476 0 0
IRS activation R-HSA-74713 3.341623e-01 0.476 0 0
G2 Phase R-HSA-68911 3.341623e-01 0.476 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 3.341623e-01 0.476 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.341623e-01 0.476 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 3.341623e-01 0.476 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.341623e-01 0.476 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 3.341623e-01 0.476 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 2.886341e-01 0.540 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.886341e-01 0.540 0 0
Regulation by c-FLIP R-HSA-3371378 2.886341e-01 0.540 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.886341e-01 0.540 0 0
Dimerization of procaspase-8 R-HSA-69416 2.886341e-01 0.540 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 2.536190e-01 0.596 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.251960e-01 0.647 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.251960e-01 0.647 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.279772e-01 0.642 0 0
Negative regulation of FLT3 R-HSA-9706369 2.563242e-01 0.591 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 2.563242e-01 0.591 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.346552e-01 0.475 0 0
Interleukin-21 signaling R-HSA-9020958 3.346552e-01 0.475 0 0
WNT mediated activation of DVL R-HSA-201688 3.346552e-01 0.475 0 0
CASP8 activity is inhibited R-HSA-5218900 3.346552e-01 0.475 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 3.947436e-01 0.404 0 0
NGF-independant TRKA activation R-HSA-187024 3.947436e-01 0.404 0 0
Cam-PDE 1 activation R-HSA-111957 3.947436e-01 0.404 0 0
PKB-mediated events R-HSA-109703 3.947436e-01 0.404 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.947436e-01 0.404 0 0
PDE3B signalling R-HSA-165160 3.947436e-01 0.404 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.947436e-01 0.404 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 2.556026e-01 0.592 0 0
HIV elongation arrest and recovery R-HSA-167287 2.268518e-01 0.644 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.268518e-01 0.644 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.287154e-01 0.483 0 0
Deadenylation of mRNA R-HSA-429947 2.531470e-01 0.597 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 2.840691e-01 0.547 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.805278e-01 0.420 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.805278e-01 0.420 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 3.211400e-01 0.493 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.211400e-01 0.493 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 3.211400e-01 0.493 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 2.458240e-01 0.609 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 2.733437e-01 0.563 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 3.131770e-01 0.504 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.131770e-01 0.504 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 3.131770e-01 0.504 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.619660e-01 0.582 0 0
GAB1 signalosome R-HSA-180292 3.542681e-01 0.451 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.542681e-01 0.451 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 3.542681e-01 0.451 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.542681e-01 0.451 0 0
EGFR downregulation R-HSA-182971 2.975214e-01 0.526 0 0
Trafficking of AMPA receptors R-HSA-399719 2.975214e-01 0.526 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 2.975214e-01 0.526 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.900501e-01 0.538 0 0
FGFR2 alternative splicing R-HSA-6803529 3.427293e-01 0.465 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.427293e-01 0.465 0 0
Notch-HLH transcription pathway R-HSA-350054 3.427293e-01 0.465 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 4.256682e-01 0.371 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.256682e-01 0.371 0 0
Regulation of PTEN stability and activity R-HSA-8948751 2.453865e-01 0.610 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.453865e-01 0.610 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.828548e-01 0.548 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.320730e-01 0.479 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 3.320730e-01 0.479 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.048354e-01 0.393 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 4.048354e-01 0.393 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 4.048354e-01 0.393 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.875249e-01 0.412 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.875249e-01 0.412 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.725347e-01 0.429 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.725347e-01 0.429 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.807946e-01 0.552 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.990775e-01 0.524 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.990775e-01 0.524 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.371333e-01 0.472 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.479310e-01 0.459 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.865279e-01 0.413 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.865279e-01 0.413 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.206694e-01 0.376 0 0
Differentiation of T cells R-HSA-9945266 4.423736e-01 0.354 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 4.423736e-01 0.354 0 0
Phosphorylation of the APC/C R-HSA-176412 4.423736e-01 0.354 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 4.423736e-01 0.354 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.008018e-01 0.522 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.469552e-01 0.460 0 0
Dual Incision in GG-NER R-HSA-5696400 3.977562e-01 0.400 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.426158e-01 0.465 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.070706e-01 0.390 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.374333e-01 0.359 0 0
PLC beta mediated events R-HSA-112043 3.943399e-01 0.404 0 0
Ca-dependent events R-HSA-111996 2.372353e-01 0.625 0 0
Mismatch Repair R-HSA-5358508 3.542681e-01 0.451 0 0
G-protein beta:gamma signalling R-HSA-397795 3.471636e-01 0.459 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.709978e-01 0.567 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.406641e-01 0.619 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.471636e-01 0.459 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 4.333156e-01 0.363 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.211400e-01 0.493 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.828548e-01 0.548 0 0
Cellular response to hypoxia R-HSA-1234174 2.670086e-01 0.573 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.308438e-01 0.366 0 0
G1 Phase R-HSA-69236 3.925464e-01 0.406 0 0
Cyclin D associated events in G1 R-HSA-69231 3.925464e-01 0.406 0 0
Integrin signaling R-HSA-354192 3.471636e-01 0.459 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.308438e-01 0.366 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.805278e-01 0.420 0 0
FGFR1 ligand binding and activation R-HSA-190242 3.542681e-01 0.451 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.206694e-01 0.376 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 3.833006e-01 0.416 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.149929e-01 0.382 0 0
TCR signaling R-HSA-202403 2.653349e-01 0.576 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 2.886341e-01 0.540 0 0
DCC mediated attractive signaling R-HSA-418885 2.251960e-01 0.647 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.792699e-01 0.421 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.596217e-01 0.444 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.444324e-01 0.463 0 0
Synthesis of DNA R-HSA-69239 2.982098e-01 0.525 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.484393e-01 0.605 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.719409e-01 0.566 0 0
p38MAPK events R-HSA-171007 2.251960e-01 0.647 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 3.947436e-01 0.404 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.556026e-01 0.592 0 0
Signalling to RAS R-HSA-167044 2.840691e-01 0.547 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 4.423736e-01 0.354 0 0
Regulation of Apoptosis R-HSA-169911 4.231316e-01 0.374 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 3.705228e-01 0.431 0 0
Regulation of mitotic cell cycle R-HSA-453276 3.705228e-01 0.431 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.361250e-01 0.473 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.279160e-01 0.369 0 0
Opioid Signalling R-HSA-111885 3.197623e-01 0.495 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.884005e-01 0.540 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 2.788924e-01 0.555 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.131770e-01 0.504 0 0
Adaptive Immune System R-HSA-1280218 4.363513e-01 0.360 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.470794e-01 0.607 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.246337e-01 0.649 0 0
Adipogenesis R-HSA-9843745 3.712402e-01 0.430 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.886341e-01 0.540 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.536190e-01 0.596 0 0
Regulation of IFNG signaling R-HSA-877312 2.908381e-01 0.536 0 0
Platelet calcium homeostasis R-HSA-418360 2.497492e-01 0.602 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.725347e-01 0.429 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.321849e-01 0.364 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.141030e-01 0.503 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.545459e-01 0.450 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.975214e-01 0.526 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.875249e-01 0.412 0 0
Degradation of DVL R-HSA-4641258 2.218477e-01 0.654 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 4.423736e-01 0.354 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.495153e-01 0.457 0 0
Cardiogenesis R-HSA-9733709 2.246337e-01 0.649 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.805278e-01 0.420 0 0
Frs2-mediated activation R-HSA-170968 3.287154e-01 0.483 0 0
Signaling by WNT in cancer R-HSA-4791275 3.221667e-01 0.492 0 0
HCMV Infection R-HSA-9609646 3.441942e-01 0.463 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 3.341623e-01 0.476 0 0
Pyrophosphate hydrolysis R-HSA-71737 3.341623e-01 0.476 0 0
The NLRP3 inflammasome R-HSA-844456 2.279772e-01 0.642 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.947436e-01 0.404 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 3.947436e-01 0.404 0 0
FGFR1c ligand binding and activation R-HSA-190373 3.287154e-01 0.483 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.828548e-01 0.548 0 0
Negative regulation of MET activity R-HSA-6807004 4.206694e-01 0.376 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 4.138799e-01 0.383 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 4.411387e-01 0.355 1 1
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.308438e-01 0.366 0 0
Circadian clock R-HSA-9909396 3.843548e-01 0.415 0 0
NGF-stimulated transcription R-HSA-9031628 3.581119e-01 0.446 0 0
Ion homeostasis R-HSA-5578775 2.990775e-01 0.524 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.246337e-01 0.649 0 0
Signal transduction by L1 R-HSA-445144 2.556026e-01 0.592 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.423736e-01 0.354 0 0
Signaling by TGFB family members R-HSA-9006936 4.013729e-01 0.396 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.327131e-01 0.364 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.925622e-01 0.534 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 3.287154e-01 0.483 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 4.048354e-01 0.393 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.925622e-01 0.534 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.865279e-01 0.413 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.950041e-01 0.403 0 0
CHL1 interactions R-HSA-447041 2.431605e-01 0.614 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 2.431605e-01 0.614 0 0
Disorders of Nervous System Development R-HSA-9697154 2.908381e-01 0.536 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.908381e-01 0.536 0 0
Pervasive developmental disorders R-HSA-9005895 2.908381e-01 0.536 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.256682e-01 0.371 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.605614e-01 0.584 0 0
Signaling by MET R-HSA-6806834 3.330743e-01 0.477 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 2.531470e-01 0.597 0 0
Mitochondrial biogenesis R-HSA-1592230 3.860023e-01 0.413 0 0
Interleukin-1 signaling R-HSA-9020702 3.575084e-01 0.447 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.977562e-01 0.400 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.629926e-01 0.580 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.052505e-01 0.515 0 0
Interleukin-7 signaling R-HSA-1266695 2.788924e-01 0.555 0 0
Hedgehog 'off' state R-HSA-5610787 4.290758e-01 0.367 0 0
Netrin-1 signaling R-HSA-373752 2.759350e-01 0.559 0 0
Signaling by Insulin receptor R-HSA-74752 3.775022e-01 0.423 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.333156e-01 0.363 0 0
Inhibition of PKR R-HSA-169131 2.884648e-01 0.540 1 1
MTF1 activates gene expression R-HSA-5660489 2.719409e-01 0.566 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.998115e-01 0.398 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.431605e-01 0.614 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 3.341623e-01 0.476 0 0
NrCAM interactions R-HSA-447038 3.341623e-01 0.476 0 0
Co-stimulation by ICOS R-HSA-9927354 2.886341e-01 0.540 0 0
Signaling by LTK R-HSA-9842663 2.908381e-01 0.536 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 3.346552e-01 0.475 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 3.947436e-01 0.404 0 0
VEGF ligand-receptor interactions R-HSA-194313 3.947436e-01 0.404 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.287154e-01 0.483 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.531470e-01 0.597 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.052505e-01 0.515 0 0
Degradation of CDH1 R-HSA-9766229 2.692816e-01 0.570 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.024105e-01 0.395 0 0
Stabilization of p53 R-HSA-69541 3.833006e-01 0.416 0 0
DAP12 interactions R-HSA-2172127 3.925464e-01 0.406 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.149929e-01 0.382 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.149929e-01 0.382 0 0
Interleukin-1 family signaling R-HSA-446652 2.466573e-01 0.608 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.471636e-01 0.459 0 0
Diseases of DNA repair R-HSA-9675135 4.374333e-01 0.359 0 0
Base Excision Repair R-HSA-73884 2.506778e-01 0.601 0 0
DNA Damage Reversal R-HSA-73942 2.251960e-01 0.647 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.431605e-01 0.614 0 0
Regulation of beta-cell development R-HSA-186712 2.567227e-01 0.591 0 0
Signal regulatory protein family interactions R-HSA-391160 3.668390e-01 0.436 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.977562e-01 0.400 0 0
TGFBR3 expression R-HSA-9839394 2.788924e-01 0.555 0 0
FOXO-mediated transcription R-HSA-9614085 2.520879e-01 0.598 0 0
Signaling by NOTCH4 R-HSA-9013694 2.395504e-01 0.621 0 0
Signaling by TGFBR3 R-HSA-9839373 4.374333e-01 0.359 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 2.719409e-01 0.566 0 0
Inhibition of membrane repair R-HSA-9635644 3.998115e-01 0.398 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.998115e-01 0.398 0 0
PTK6 Activates STAT3 R-HSA-8849474 3.341623e-01 0.476 0 0
Josephin domain DUBs R-HSA-5689877 3.805278e-01 0.420 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.628821e-01 0.580 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.070706e-01 0.390 0 0
MET activates RAS signaling R-HSA-8851805 2.908381e-01 0.536 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 4.374703e-01 0.359 0 0
CASP4 inflammasome assembly R-HSA-9948001 3.805278e-01 0.420 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.299517e-01 0.638 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.140392e-01 0.383 0 0
Non-canonical inflammasome activation R-HSA-9686114 3.668390e-01 0.436 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.840691e-01 0.547 0 0
Signaling by Leptin R-HSA-2586552 3.805278e-01 0.420 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 2.908381e-01 0.536 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 3.670291e-01 0.435 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.256682e-01 0.371 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.431728e-01 0.353 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.431728e-01 0.353 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.431728e-01 0.353 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 4.431728e-01 0.353 0 0
Dual incision in TC-NER R-HSA-6782135 4.482491e-01 0.348 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.484204e-01 0.348 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.493272e-01 0.347 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.526749e-01 0.344 0 0
G2/M DNA replication checkpoint R-HSA-69478 4.526749e-01 0.344 0 0
Autointegration results in viral DNA circles R-HSA-177539 4.526749e-01 0.344 0 0
Abacavir transmembrane transport R-HSA-2161517 4.526749e-01 0.344 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 4.526749e-01 0.344 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.527955e-01 0.344 0 0
Basigin interactions R-HSA-210991 4.534822e-01 0.343 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.534822e-01 0.343 0 0
ERK/MAPK targets R-HSA-198753 4.534822e-01 0.343 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.545358e-01 0.342 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.545358e-01 0.342 0 0
HIV Transcription Initiation R-HSA-167161 4.545358e-01 0.342 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.545358e-01 0.342 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.597969e-01 0.337 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.616987e-01 0.336 0 0
TRP channels R-HSA-3295583 4.616987e-01 0.336 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.644089e-01 0.333 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 4.681824e-01 0.330 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.696010e-01 0.328 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.696010e-01 0.328 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.696010e-01 0.328 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.696010e-01 0.328 0 0
ERKs are inactivated R-HSA-202670 4.696010e-01 0.328 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.696010e-01 0.328 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.735252e-01 0.325 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.735252e-01 0.325 0 0
Signaling by NOTCH R-HSA-157118 4.745535e-01 0.324 0 0
Generic Transcription Pathway R-HSA-212436 4.748474e-01 0.323 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.791670e-01 0.320 0 0
Phase 2 - plateau phase R-HSA-5576893 4.791670e-01 0.320 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.791670e-01 0.320 0 0
Synthesis of PG R-HSA-1483148 4.791670e-01 0.320 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 4.857668e-01 0.314 0 0
Attachment and Entry R-HSA-9694614 4.857668e-01 0.314 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.880761e-01 0.312 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.886562e-01 0.311 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.886562e-01 0.311 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.886562e-01 0.311 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.886562e-01 0.311 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.886562e-01 0.311 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.889722e-01 0.311 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.889722e-01 0.311 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.889722e-01 0.311 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.908070e-01 0.309 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.908070e-01 0.309 0 0
Cristae formation R-HSA-8949613 4.908070e-01 0.309 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.908070e-01 0.309 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 4.937391e-01 0.307 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 4.937391e-01 0.307 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 4.937391e-01 0.307 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 4.937391e-01 0.307 0 0
Defective PAPSS2 causes SEMD-PA R-HSA-3560796 4.937391e-01 0.307 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.937391e-01 0.307 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.937391e-01 0.307 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 4.937391e-01 0.307 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 4.937391e-01 0.307 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.937391e-01 0.307 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.937391e-01 0.307 0 0
Glycogen storage disease type II (GAA) R-HSA-5357609 4.937391e-01 0.307 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 4.937391e-01 0.307 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.937391e-01 0.307 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.937391e-01 0.307 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.948980e-01 0.305 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.948980e-01 0.305 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 4.983550e-01 0.302 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 4.983550e-01 0.302 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.983550e-01 0.302 0 0
ER-Phagosome pathway R-HSA-1236974 5.009161e-01 0.300 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.013602e-01 0.300 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.013602e-01 0.300 0 0
DNA Damage Bypass R-HSA-73893 5.040280e-01 0.298 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.040280e-01 0.298 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.040280e-01 0.298 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.073022e-01 0.295 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 5.073022e-01 0.295 0 0
Regulation of PTEN localization R-HSA-8948747 5.073022e-01 0.295 0 0
TRIF-mediated programmed cell death R-HSA-2562578 5.073022e-01 0.295 0 0
PTK6 Expression R-HSA-8849473 5.073022e-01 0.295 0 0
IFNG signaling activates MAPKs R-HSA-9732724 5.073022e-01 0.295 0 0
Recycling of eIF2:GDP R-HSA-72731 5.073022e-01 0.295 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.073022e-01 0.295 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 5.073022e-01 0.295 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.073022e-01 0.295 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.082581e-01 0.294 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.082581e-01 0.294 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.086322e-01 0.294 0 0
G-protein mediated events R-HSA-112040 5.106602e-01 0.292 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.119522e-01 0.291 0 0
Interleukin-15 signaling R-HSA-8983432 5.119522e-01 0.291 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.119522e-01 0.291 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.119522e-01 0.291 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.129192e-01 0.290 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.129192e-01 0.290 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.129192e-01 0.290 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.149731e-01 0.288 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.149731e-01 0.288 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.173509e-01 0.286 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.173509e-01 0.286 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 5.193792e-01 0.285 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.193792e-01 0.285 0 0
Inflammasomes R-HSA-622312 5.193792e-01 0.285 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.211826e-01 0.283 0 0
Vpu mediated degradation of CD4 R-HSA-180534 5.211826e-01 0.283 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.228258e-01 0.282 0 0
Proteasome assembly R-HSA-9907900 5.243473e-01 0.280 0 0
Transcription of the HIV genome R-HSA-167172 5.296164e-01 0.276 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.330019e-01 0.273 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.431863e-01 0.265 0 0
HIV Transcription Elongation R-HSA-167169 5.468613e-01 0.262 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.468613e-01 0.262 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.468613e-01 0.262 0 0
Glycogen metabolism R-HSA-8982491 5.468613e-01 0.262 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 5.469437e-01 0.262 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 5.469437e-01 0.262 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 5.469437e-01 0.262 0 0
Signal amplification R-HSA-392518 5.469437e-01 0.262 0 0
Mitophagy R-HSA-5205647 5.469437e-01 0.262 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.469437e-01 0.262 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 5.469437e-01 0.262 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.469630e-01 0.262 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.469630e-01 0.262 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.469630e-01 0.262 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.469630e-01 0.262 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 5.469630e-01 0.262 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.470981e-01 0.262 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 5.471930e-01 0.262 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.471930e-01 0.262 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.473004e-01 0.262 0 0
mRNA Capping R-HSA-72086 5.473004e-01 0.262 0 0
Syndecan interactions R-HSA-3000170 5.480862e-01 0.261 0 0
Growth hormone receptor signaling R-HSA-982772 5.480862e-01 0.261 0 0
Interleukin-20 family signaling R-HSA-8854691 5.480862e-01 0.261 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.488172e-01 0.261 0 0
Protein ubiquitination R-HSA-8852135 5.488172e-01 0.261 0 0
Polo-like kinase mediated events R-HSA-156711 5.495922e-01 0.260 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 5.495922e-01 0.260 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 5.495922e-01 0.260 0 0
CD28 dependent Vav1 pathway R-HSA-389359 5.524387e-01 0.258 0 0
FGFR4 ligand binding and activation R-HSA-190322 5.524387e-01 0.258 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 5.524387e-01 0.258 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 5.524387e-01 0.258 0 0
Processing of SMDT1 R-HSA-8949664 5.524387e-01 0.258 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 5.524387e-01 0.258 0 0
Formation of axial mesoderm R-HSA-9796292 5.524387e-01 0.258 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 5.524387e-01 0.258 0 0
Maturation of nucleoprotein R-HSA-9683610 5.524387e-01 0.258 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.524387e-01 0.258 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.524387e-01 0.258 0 0
Type I hemidesmosome assembly R-HSA-446107 5.582409e-01 0.253 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.582409e-01 0.253 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 5.582409e-01 0.253 0 0
MET receptor recycling R-HSA-8875656 5.582409e-01 0.253 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 5.582409e-01 0.253 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 5.582409e-01 0.253 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 5.582409e-01 0.253 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 5.582409e-01 0.253 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 5.582409e-01 0.253 0 0
Sodium/Proton exchangers R-HSA-425986 5.582409e-01 0.253 0 0
Interleukin-18 signaling R-HSA-9012546 5.582409e-01 0.253 0 0
Signaling by NOTCH1 R-HSA-1980143 5.666048e-01 0.247 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 5.675825e-01 0.246 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 5.703925e-01 0.244 0 0
PERK regulates gene expression R-HSA-381042 5.720991e-01 0.243 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.720991e-01 0.243 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 5.720991e-01 0.243 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.729718e-01 0.242 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.729718e-01 0.242 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 5.729718e-01 0.242 0 0
Defective CYP7B1 causes SPG5A and CBAS3 R-HSA-5579013 5.729718e-01 0.242 0 0
Invadopodia formation R-HSA-8941237 5.729718e-01 0.242 0 0
MET activates PTPN11 R-HSA-8865999 5.729718e-01 0.242 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.729718e-01 0.242 0 0
Signalling to STAT3 R-HSA-198745 5.729718e-01 0.242 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 5.729718e-01 0.242 0 0
MET interacts with TNS proteins R-HSA-8875513 5.729718e-01 0.242 0 0
Type II Na+/Pi cotransporters R-HSA-427589 5.729718e-01 0.242 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.729718e-01 0.242 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.729718e-01 0.242 0 0
FasL/ CD95L signaling R-HSA-75157 5.729718e-01 0.242 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.744705e-01 0.241 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.778483e-01 0.238 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.778483e-01 0.238 0 0
Interleukin-6 family signaling R-HSA-6783589 5.778483e-01 0.238 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.814342e-01 0.235 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.814342e-01 0.235 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.814342e-01 0.235 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.818486e-01 0.235 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.823685e-01 0.235 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 5.824550e-01 0.235 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.828654e-01 0.234 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.828654e-01 0.234 0 0
Translesion Synthesis by POLH R-HSA-110320 5.828654e-01 0.234 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.834398e-01 0.234 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.908516e-01 0.229 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.908516e-01 0.229 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.908582e-01 0.229 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.908582e-01 0.229 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 5.908582e-01 0.229 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.933585e-01 0.227 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.933585e-01 0.227 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.933585e-01 0.227 0 0
FGFR2 mutant receptor activation R-HSA-1839126 5.965774e-01 0.224 0 0
PCP/CE pathway R-HSA-4086400 6.013369e-01 0.221 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 6.027933e-01 0.220 0 0
ARMS-mediated activation R-HSA-170984 6.053076e-01 0.218 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.053076e-01 0.218 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 6.053076e-01 0.218 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.053076e-01 0.218 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.053076e-01 0.218 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 6.053076e-01 0.218 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.053076e-01 0.218 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 6.053076e-01 0.218 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.065353e-01 0.217 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 6.073211e-01 0.217 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.090334e-01 0.215 0 0
Intraflagellar transport R-HSA-5620924 6.120247e-01 0.213 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.146711e-01 0.211 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.146711e-01 0.211 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.146711e-01 0.211 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.146711e-01 0.211 0 0
Protein hydroxylation R-HSA-9629569 6.146711e-01 0.211 0 0
Downstream TCR signaling R-HSA-202424 6.149278e-01 0.211 0 0
Hemostasis R-HSA-109582 6.150828e-01 0.211 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.164635e-01 0.210 0 0
Ca2+ pathway R-HSA-4086398 6.202686e-01 0.207 0 0
Degradation of AXIN R-HSA-4641257 6.203176e-01 0.207 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 6.224415e-01 0.206 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 6.224415e-01 0.206 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.226398e-01 0.206 0 0
MAP kinase activation R-HSA-450294 6.254174e-01 0.204 0 0
Platelet homeostasis R-HSA-418346 6.257959e-01 0.204 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.270780e-01 0.203 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.270780e-01 0.203 0 0
p75NTR signals via NF-kB R-HSA-193639 6.270780e-01 0.203 0 0
Signaling by Activin R-HSA-1502540 6.270780e-01 0.203 0 0
Gastrulation R-HSA-9758941 6.308588e-01 0.200 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.334900e-01 0.198 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.340670e-01 0.198 0 0
Suppression of phagosomal maturation R-HSA-9637687 6.340670e-01 0.198 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.373892e-01 0.196 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.373892e-01 0.196 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 6.383962e-01 0.195 0 0
betaKlotho-mediated ligand binding R-HSA-1307965 6.398080e-01 0.194 0 0
Nucleotide catabolism defects R-HSA-9735786 6.398080e-01 0.194 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 6.398080e-01 0.194 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 6.398080e-01 0.194 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 6.398080e-01 0.194 0 0
Signaling by MAP2K mutants R-HSA-9652169 6.398080e-01 0.194 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 6.398080e-01 0.194 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 6.398080e-01 0.194 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 6.398080e-01 0.194 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 6.398080e-01 0.194 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 6.398080e-01 0.194 0 0
Regulated Necrosis R-HSA-5218859 6.403417e-01 0.194 0 0
Transmission across Chemical Synapses R-HSA-112315 6.407898e-01 0.193 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 6.432688e-01 0.192 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.436288e-01 0.191 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.437956e-01 0.191 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.449221e-01 0.190 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.449221e-01 0.190 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.484665e-01 0.188 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 6.484665e-01 0.188 0 0
Signal attenuation R-HSA-74749 6.484665e-01 0.188 0 0
Pexophagy R-HSA-9664873 6.484665e-01 0.188 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.484665e-01 0.188 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.484665e-01 0.188 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.506990e-01 0.187 0 0
Nuclear RNA decay R-HSA-9930044 6.506990e-01 0.187 0 0
HCMV Late Events R-HSA-9610379 6.533781e-01 0.185 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.538578e-01 0.185 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 6.538578e-01 0.185 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.540539e-01 0.184 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 6.575983e-01 0.182 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.583701e-01 0.182 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.610243e-01 0.180 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.610243e-01 0.180 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.610243e-01 0.180 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.610243e-01 0.180 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.610243e-01 0.180 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 6.610243e-01 0.180 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.610243e-01 0.180 0 0
RAS processing R-HSA-9648002 6.653898e-01 0.177 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.653898e-01 0.177 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 6.674772e-01 0.176 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.735615e-01 0.172 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.735615e-01 0.172 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.741595e-01 0.171 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.741595e-01 0.171 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.741595e-01 0.171 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.783814e-01 0.169 0 0
Somitogenesis R-HSA-9824272 6.786178e-01 0.168 0 0
Ion transport by P-type ATPases R-HSA-936837 6.790431e-01 0.168 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.854428e-01 0.164 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.854428e-01 0.164 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.854428e-01 0.164 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.854428e-01 0.164 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.854428e-01 0.164 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.866487e-01 0.163 0 0
Diseases of Immune System R-HSA-5260271 6.866487e-01 0.163 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 6.877878e-01 0.163 0 0
FGFR2b ligand binding and activation R-HSA-190377 6.877878e-01 0.163 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 6.877878e-01 0.163 0 0
Formation of the posterior neural plate R-HSA-9832991 6.877878e-01 0.163 0 0
Ionotropic activity of kainate receptors R-HSA-451306 6.877878e-01 0.163 0 0
Suppression of apoptosis R-HSA-9635465 6.877878e-01 0.163 0 0
Bicarbonate transporters R-HSA-425381 6.877878e-01 0.163 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 6.877878e-01 0.163 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.906899e-01 0.161 0 0
Hedgehog 'on' state R-HSA-5632684 6.906971e-01 0.161 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.926721e-01 0.159 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.926721e-01 0.159 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 6.926721e-01 0.159 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 6.926721e-01 0.159 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.926721e-01 0.159 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.926721e-01 0.159 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.926721e-01 0.159 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 6.940438e-01 0.159 1 0
NTRK2 activates RAC1 R-HSA-9032759 6.961865e-01 0.157 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 6.961865e-01 0.157 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.961865e-01 0.157 0 0
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) R-HSA-5619067 6.961865e-01 0.157 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.961865e-01 0.157 0 0
Defective F9 activation R-HSA-9673221 6.961865e-01 0.157 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 6.961865e-01 0.157 0 0
Reelin signalling pathway R-HSA-8866376 6.961865e-01 0.157 0 0
Suppression of autophagy R-HSA-9636569 6.961865e-01 0.157 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.961865e-01 0.157 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.961865e-01 0.157 0 0
Co-inhibition by BTLA R-HSA-9927353 6.961865e-01 0.157 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.961865e-01 0.157 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.961865e-01 0.157 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.961865e-01 0.157 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.961865e-01 0.157 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.965837e-01 0.157 0 0
eNOS activation R-HSA-203615 6.965837e-01 0.157 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.965837e-01 0.157 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.981080e-01 0.156 0 0
Regulation of TNFR1 signaling R-HSA-5357905 6.981080e-01 0.156 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.005590e-01 0.155 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.005590e-01 0.155 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.005590e-01 0.155 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.005590e-01 0.155 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.018169e-01 0.154 0 0
Late endosomal microautophagy R-HSA-9615710 7.092199e-01 0.149 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.092199e-01 0.149 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.164386e-01 0.145 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.189665e-01 0.143 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 7.220365e-01 0.141 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.220365e-01 0.141 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 7.220365e-01 0.141 0 0
Specification of primordial germ cells R-HSA-9827857 7.220365e-01 0.141 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.234154e-01 0.141 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.234154e-01 0.141 0 0
NF-kB is activated and signals survival R-HSA-209560 7.234154e-01 0.141 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.234154e-01 0.141 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.234154e-01 0.141 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 7.234154e-01 0.141 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.234154e-01 0.141 0 0
Sodium/Calcium exchangers R-HSA-425561 7.234154e-01 0.141 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 7.259078e-01 0.139 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.317044e-01 0.136 0 0
Neuronal System R-HSA-112316 7.339440e-01 0.134 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.347653e-01 0.134 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.382543e-01 0.132 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 7.437432e-01 0.129 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 7.437432e-01 0.129 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 7.437432e-01 0.129 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 7.437432e-01 0.129 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 7.437432e-01 0.129 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 7.437432e-01 0.129 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 7.437432e-01 0.129 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 7.437432e-01 0.129 0 0
Signaling by MAPK mutants R-HSA-9652817 7.437432e-01 0.129 0 0
Signaling by RNF43 mutants R-HSA-5340588 7.437432e-01 0.129 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 7.437432e-01 0.129 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 7.437432e-01 0.129 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 7.437432e-01 0.129 0 0
Pentose phosphate pathway disease R-HSA-6791465 7.437432e-01 0.129 0 0
Synthesis of PS R-HSA-1483101 7.437432e-01 0.129 0 0
Phosphorylation of Emi1 R-HSA-176417 7.437432e-01 0.129 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 7.437432e-01 0.129 0 0
Threonine catabolism R-HSA-8849175 7.437432e-01 0.129 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 7.437432e-01 0.129 0 0
TRAIL signaling R-HSA-75158 7.437432e-01 0.129 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 7.437432e-01 0.129 0 0
Amyloid fiber formation R-HSA-977225 7.448303e-01 0.128 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.491640e-01 0.125 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.491640e-01 0.125 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 7.491640e-01 0.125 0 0
Apoptotic factor-mediated response R-HSA-111471 7.491640e-01 0.125 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 7.496204e-01 0.125 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.496204e-01 0.125 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.496204e-01 0.125 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.496204e-01 0.125 0 0
Integration of energy metabolism R-HSA-163685 7.515123e-01 0.124 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.528989e-01 0.123 0 0
Polymerase switching R-HSA-69091 7.555420e-01 0.122 0 0
Leading Strand Synthesis R-HSA-69109 7.555420e-01 0.122 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 7.555420e-01 0.122 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 7.555420e-01 0.122 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.555420e-01 0.122 0 0
Interleukin-35 Signalling R-HSA-8984722 7.555420e-01 0.122 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.555420e-01 0.122 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 7.555420e-01 0.122 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.555420e-01 0.122 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.555420e-01 0.122 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.555420e-01 0.122 0 0
Voltage gated Potassium channels R-HSA-1296072 7.574907e-01 0.121 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.574907e-01 0.121 0 0
TNF signaling R-HSA-75893 7.586177e-01 0.120 0 0
Platelet degranulation R-HSA-114608 7.684461e-01 0.114 0 0
Interleukin-17 signaling R-HSA-448424 7.715848e-01 0.113 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.717258e-01 0.113 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.717258e-01 0.113 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.717258e-01 0.113 0 0
Formation of the nephric duct R-HSA-9830364 7.717258e-01 0.113 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.717258e-01 0.113 0 0
Signaling by Hedgehog R-HSA-5358351 7.717402e-01 0.113 0 0
Rap1 signalling R-HSA-392517 7.741258e-01 0.111 0 0
Other interleukin signaling R-HSA-449836 7.741258e-01 0.111 0 0
Maturation of nucleoprotein R-HSA-9694631 7.741258e-01 0.111 0 0
MET promotes cell motility R-HSA-8875878 7.756689e-01 0.110 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.837793e-01 0.106 0 0
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) R-HSA-3656244 7.838580e-01 0.106 0 0
STAT5 Activation R-HSA-9645135 7.838580e-01 0.106 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 7.838580e-01 0.106 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 7.838580e-01 0.106 0 0
Defective CHST6 causes MCDC1 R-HSA-3656225 7.838580e-01 0.106 0 0
Defective ST3GAL3 causes MCT12 and EIEE15 R-HSA-3656243 7.838580e-01 0.106 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 7.838580e-01 0.106 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 7.838580e-01 0.106 0 0
CREB phosphorylation R-HSA-199920 7.838580e-01 0.106 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 7.838580e-01 0.106 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 7.838580e-01 0.106 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 7.838580e-01 0.106 0 0
Metabolism of vitamin K R-HSA-6806664 7.838580e-01 0.106 0 0
HDL clearance R-HSA-8964011 7.838580e-01 0.106 0 0
Leukotriene receptors R-HSA-391906 7.838580e-01 0.106 0 0
Nef and signal transduction R-HSA-164944 7.838580e-01 0.106 0 0
FGFR2c ligand binding and activation R-HSA-190375 7.843906e-01 0.105 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.843906e-01 0.105 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.843906e-01 0.105 0 0
Diseases of nucleotide metabolism R-HSA-9735804 7.843906e-01 0.105 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 7.843906e-01 0.105 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.843906e-01 0.105 0 0
FGFR3 mutant receptor activation R-HSA-2033514 7.843906e-01 0.105 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.843906e-01 0.105 0 0
Immune System R-HSA-168256 7.858890e-01 0.105 1 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.922662e-01 0.101 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.922662e-01 0.101 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 7.970115e-01 0.099 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.970115e-01 0.099 0 0
Glycogen synthesis R-HSA-3322077 7.970115e-01 0.099 0 0
Signaling by NODAL R-HSA-1181150 7.970115e-01 0.099 0 0
Creatine metabolism R-HSA-71288 7.970115e-01 0.099 0 0
Stimuli-sensing channels R-HSA-2672351 8.057963e-01 0.094 0 0
Toll-like Receptor Cascades R-HSA-168898 8.093649e-01 0.092 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.102001e-01 0.091 0 0
FGFR3c ligand binding and activation R-HSA-190372 8.102001e-01 0.091 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.102001e-01 0.091 0 0
Physiological factors R-HSA-5578768 8.102001e-01 0.091 0 0
P2Y receptors R-HSA-417957 8.102001e-01 0.091 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.102001e-01 0.091 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.102001e-01 0.091 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.102988e-01 0.091 0 0
Insulin processing R-HSA-264876 8.112947e-01 0.091 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 8.176951e-01 0.087 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 8.176951e-01 0.087 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 8.176951e-01 0.087 0 0
FGFR3b ligand binding and activation R-HSA-190371 8.176951e-01 0.087 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 8.176951e-01 0.087 0 0
DAG1 core M1 glycosylations R-HSA-8932506 8.176951e-01 0.087 0 0
Cysteine formation from homocysteine R-HSA-1614603 8.176951e-01 0.087 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 8.176951e-01 0.087 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 8.176951e-01 0.087 0 0
VLDL clearance R-HSA-8964046 8.176951e-01 0.087 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 8.176951e-01 0.087 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 8.176951e-01 0.087 0 0
Biosynthesis of maresin conjugates in tissue regeneration (MCTR) R-HSA-9026762 8.176951e-01 0.087 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 8.176951e-01 0.087 0 0
Lagging Strand Synthesis R-HSA-69186 8.179234e-01 0.087 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 8.179234e-01 0.087 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.179234e-01 0.087 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.244153e-01 0.084 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.251885e-01 0.083 0 0
Interferon alpha/beta signaling R-HSA-909733 8.294341e-01 0.081 1 1
RSV-host interactions R-HSA-9833110 8.304472e-01 0.081 1 0
Processive synthesis on the lagging strand R-HSA-69183 8.332148e-01 0.079 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.332148e-01 0.079 0 0
Translesion synthesis by REV1 R-HSA-110312 8.332148e-01 0.079 0 0
FGFR3 ligand binding and activation R-HSA-190239 8.332148e-01 0.079 0 0
Protein lipoylation R-HSA-9857492 8.332148e-01 0.079 0 0
Transport and metabolism of PAPS R-HSA-174362 8.332148e-01 0.079 0 0
Biotin transport and metabolism R-HSA-196780 8.332148e-01 0.079 0 0
Formation of the anterior neural plate R-HSA-9823739 8.332148e-01 0.079 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.369730e-01 0.077 0 0
Gluconeogenesis R-HSA-70263 8.376939e-01 0.077 0 0
Intra-Golgi traffic R-HSA-6811438 8.381776e-01 0.077 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.381776e-01 0.077 0 0
G alpha (z) signalling events R-HSA-418597 8.382906e-01 0.077 0 0
Signaling by NOTCH3 R-HSA-9012852 8.382906e-01 0.077 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.422007e-01 0.075 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 8.450660e-01 0.073 0 0
ABC-family proteins mediated transport R-HSA-382556 8.452630e-01 0.073 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 8.462366e-01 0.073 0 0
phospho-PLA2 pathway R-HSA-111995 8.462366e-01 0.073 0 0
DAG1 core M2 glycosylations R-HSA-8932504 8.462366e-01 0.073 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 8.462366e-01 0.073 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 8.462366e-01 0.073 0 0
Interleukin-9 signaling R-HSA-8985947 8.462366e-01 0.073 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 8.462366e-01 0.073 0 0
Interleukin-23 signaling R-HSA-9020933 8.462366e-01 0.073 0 0
Nucleotide salvage defects R-HSA-9734207 8.462366e-01 0.073 0 0
SLC-mediated bile acid transport R-HSA-9958517 8.462366e-01 0.073 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 8.462366e-01 0.073 0 0
TGFBR3 PTM regulation R-HSA-9839383 8.462366e-01 0.073 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 8.462366e-01 0.073 0 0
RSK activation R-HSA-444257 8.462366e-01 0.073 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.513028e-01 0.070 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.513922e-01 0.070 0 0
Translesion synthesis by POLI R-HSA-5656121 8.536772e-01 0.069 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.536772e-01 0.069 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.536772e-01 0.069 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.536772e-01 0.069 0 0
Killing mechanisms R-HSA-9664420 8.536772e-01 0.069 0 0
Attachment and Entry R-HSA-9678110 8.536772e-01 0.069 0 0
Atorvastatin ADME R-HSA-9754706 8.536772e-01 0.069 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.542764e-01 0.068 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.542764e-01 0.068 0 0
RUNX2 regulates bone development R-HSA-8941326 8.543376e-01 0.068 0 0
NCAM1 interactions R-HSA-419037 8.673227e-01 0.062 0 0
Cardiac conduction R-HSA-5576891 8.680931e-01 0.061 0 0
Developmental Cell Lineages R-HSA-9734767 8.685798e-01 0.061 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.699519e-01 0.061 0 0
Carnitine shuttle R-HSA-200425 8.699519e-01 0.061 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.699519e-01 0.061 0 0
Lipophagy R-HSA-9613354 8.703111e-01 0.060 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.703111e-01 0.060 0 0
MAPK1 (ERK2) activation R-HSA-112411 8.703111e-01 0.060 0 0
Interleukin-1 processing R-HSA-448706 8.703111e-01 0.060 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 8.703111e-01 0.060 0 0
Regulated proteolysis of p75NTR R-HSA-193692 8.703111e-01 0.060 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.703111e-01 0.060 0 0
Translesion synthesis by POLK R-HSA-5655862 8.718221e-01 0.060 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 8.718221e-01 0.060 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.718221e-01 0.060 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.718221e-01 0.060 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.718221e-01 0.060 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.718221e-01 0.060 0 0
Passive transport by Aquaporins R-HSA-432047 8.718221e-01 0.060 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.718221e-01 0.060 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 8.718221e-01 0.060 0 0
Response to metal ions R-HSA-5660526 8.718221e-01 0.060 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.735892e-01 0.059 0 0
Budding and maturation of HIV virion R-HSA-162588 8.735892e-01 0.059 0 0
Extension of Telomeres R-HSA-180786 8.813429e-01 0.055 0 0
Glycogen storage diseases R-HSA-3229121 8.878735e-01 0.052 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.878735e-01 0.052 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.878735e-01 0.052 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.878735e-01 0.052 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.903734e-01 0.050 0 0
tRNA Aminoacylation R-HSA-379724 8.904862e-01 0.050 0 0
Binding and entry of HIV virion R-HSA-173107 8.906174e-01 0.050 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.906174e-01 0.050 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.906174e-01 0.050 0 0
DNA replication initiation R-HSA-68952 8.906174e-01 0.050 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.906174e-01 0.050 0 0
Interleukin-27 signaling R-HSA-9020956 8.906174e-01 0.050 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.906174e-01 0.050 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.906174e-01 0.050 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.906174e-01 0.050 0 0
Formation of apoptosome R-HSA-111458 8.906174e-01 0.050 0 0
Regulation of the apoptosome activity R-HSA-9627069 8.906174e-01 0.050 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 8.906174e-01 0.050 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.956699e-01 0.048 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.956699e-01 0.048 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.968895e-01 0.047 0 0
PKA activation R-HSA-163615 9.020421e-01 0.045 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 9.020421e-01 0.045 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.020421e-01 0.045 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.020421e-01 0.045 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.020421e-01 0.045 0 0
Nephron development R-HSA-9831926 9.020421e-01 0.045 0 0
DAG1 core M3 glycosylations R-HSA-8932505 9.077452e-01 0.042 0 0
vRNA Synthesis R-HSA-192814 9.077452e-01 0.042 0 0
vRNP Assembly R-HSA-192905 9.077452e-01 0.042 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 9.077452e-01 0.042 0 0
Hormone ligand-binding receptors R-HSA-375281 9.077452e-01 0.042 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 9.077452e-01 0.042 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 9.077452e-01 0.042 0 0
LGI-ADAM interactions R-HSA-5682910 9.077452e-01 0.042 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 9.077452e-01 0.042 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 9.077452e-01 0.042 0 0
Prostanoid ligand receptors R-HSA-391908 9.077452e-01 0.042 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 9.077452e-01 0.042 0 0
Dissolution of Fibrin Clot R-HSA-75205 9.077452e-01 0.042 0 0
Heme degradation R-HSA-189483 9.078298e-01 0.042 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.083796e-01 0.042 0 0
Neurotransmitter release cycle R-HSA-112310 9.103555e-01 0.041 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.145238e-01 0.039 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.145238e-01 0.039 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.145238e-01 0.039 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.145238e-01 0.039 0 0
Diseases of hemostasis R-HSA-9671793 9.145238e-01 0.039 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.145238e-01 0.039 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.145238e-01 0.039 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.164801e-01 0.038 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.172604e-01 0.038 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.172604e-01 0.038 0 0
Signaling by NOTCH2 R-HSA-1980145 9.172604e-01 0.038 0 0
Integrin cell surface interactions R-HSA-216083 9.179223e-01 0.037 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.184500e-01 0.037 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.186958e-01 0.037 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.186958e-01 0.037 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.186958e-01 0.037 0 0
DS-GAG biosynthesis R-HSA-2022923 9.221918e-01 0.035 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 9.221918e-01 0.035 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 9.221918e-01 0.035 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 9.221918e-01 0.035 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.254995e-01 0.034 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.254995e-01 0.034 0 0
Pregnenolone biosynthesis R-HSA-196108 9.254995e-01 0.034 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.256241e-01 0.034 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.262860e-01 0.033 0 0
Telomere Extension By Telomerase R-HSA-171319 9.279403e-01 0.032 0 0
Pyroptosis R-HSA-5620971 9.279403e-01 0.032 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.343769e-01 0.029 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 9.343769e-01 0.029 0 0
Maple Syrup Urine Disease R-HSA-9865114 9.343769e-01 0.029 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 9.343769e-01 0.029 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 9.343769e-01 0.029 0 0
OAS antiviral response R-HSA-8983711 9.343769e-01 0.029 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.351346e-01 0.029 0 0
G-protein activation R-HSA-202040 9.351346e-01 0.029 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.351346e-01 0.029 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.351346e-01 0.029 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.351346e-01 0.029 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.351346e-01 0.029 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.351346e-01 0.029 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.362095e-01 0.029 0 0
Ion channel transport R-HSA-983712 9.388628e-01 0.027 0 0
Infectious disease R-HSA-5663205 9.393107e-01 0.027 1 0
Surfactant metabolism R-HSA-5683826 9.399753e-01 0.027 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.407593e-01 0.027 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.423568e-01 0.026 0 0
Metabolism of polyamines R-HSA-351202 9.423568e-01 0.026 0 0
Ribavirin ADME R-HSA-9755088 9.435797e-01 0.025 0 0
Assembly Of The HIV Virion R-HSA-175474 9.435797e-01 0.025 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.435797e-01 0.025 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.435940e-01 0.025 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.435940e-01 0.025 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.435940e-01 0.025 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.446543e-01 0.025 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 9.446543e-01 0.025 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.448746e-01 0.025 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.459229e-01 0.024 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.459229e-01 0.024 0 0
Interferon gamma signaling R-HSA-877300 9.486929e-01 0.023 0 0
Cargo concentration in the ER R-HSA-5694530 9.501777e-01 0.022 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.509713e-01 0.022 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.509713e-01 0.022 0 0
LDL clearance R-HSA-8964038 9.509713e-01 0.022 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.513320e-01 0.022 0 0
Mitochondrial protein import R-HSA-1268020 9.521963e-01 0.021 0 0
Removal of the Flap Intermediate R-HSA-69166 9.533227e-01 0.021 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.533227e-01 0.021 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.533227e-01 0.021 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.533227e-01 0.021 0 0
Hydrolysis of LPC R-HSA-1483115 9.533227e-01 0.021 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.533227e-01 0.021 0 0
cGMP effects R-HSA-418457 9.533227e-01 0.021 0 0
Prolactin receptor signaling R-HSA-1170546 9.533227e-01 0.021 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 9.533227e-01 0.021 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.533227e-01 0.021 0 0
Malate-aspartate shuttle R-HSA-9856872 9.533227e-01 0.021 0 0
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) R-HSA-9026766 9.533227e-01 0.021 0 0
Ciprofloxacin ADME R-HSA-9793528 9.533227e-01 0.021 0 0
HDL assembly R-HSA-8963896 9.533227e-01 0.021 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.533227e-01 0.021 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.543010e-01 0.020 0 0
ABC transporter disorders R-HSA-5619084 9.551909e-01 0.020 0 0
Synthesis of PC R-HSA-1483191 9.562443e-01 0.019 0 0
PPARA activates gene expression R-HSA-1989781 9.572331e-01 0.019 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.574321e-01 0.019 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.574321e-01 0.019 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.602152e-01 0.018 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 9.606338e-01 0.017 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 9.606338e-01 0.017 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.606338e-01 0.017 0 0
Protein repair R-HSA-5676934 9.606338e-01 0.017 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.606338e-01 0.017 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.606338e-01 0.017 0 0
Other semaphorin interactions R-HSA-416700 9.606338e-01 0.017 0 0
Recycling of bile acids and salts R-HSA-159418 9.612488e-01 0.017 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.623677e-01 0.017 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.623784e-01 0.017 0 0
tRNA processing R-HSA-72306 9.624791e-01 0.017 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.647347e-01 0.016 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.658740e-01 0.015 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.658740e-01 0.015 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.658740e-01 0.015 0 0
Innate Immune System R-HSA-168249 9.663510e-01 0.015 0 0
Heme biosynthesis R-HSA-189451 9.665125e-01 0.015 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.668001e-01 0.015 0 0
Regulation of BACH1 activity R-HSA-9708530 9.668001e-01 0.015 0 0
Fructose catabolism R-HSA-70350 9.668001e-01 0.015 0 0
G protein gated Potassium channels R-HSA-1296059 9.679903e-01 0.014 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.679903e-01 0.014 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.679903e-01 0.014 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.679903e-01 0.014 0 0
Hyaluronan degradation R-HSA-2160916 9.679903e-01 0.014 0 0
SLC transporter disorders R-HSA-5619102 9.689890e-01 0.014 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.699746e-01 0.013 0 0
Hyaluronan metabolism R-HSA-2142845 9.699746e-01 0.013 0 0
The phototransduction cascade R-HSA-2514856 9.716830e-01 0.012 0 0
Heme assimilation R-HSA-9927020 9.720008e-01 0.012 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.720008e-01 0.012 0 0
Coenzyme A biosynthesis R-HSA-196783 9.720008e-01 0.012 0 0
Fibronectin matrix formation R-HSA-1566977 9.720008e-01 0.012 0 0
Galactose catabolism R-HSA-70370 9.720008e-01 0.012 0 0
MET activates PTK2 signaling R-HSA-8874081 9.722741e-01 0.012 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.722741e-01 0.012 0 0
Abacavir ADME R-HSA-2161522 9.722741e-01 0.012 0 0
Urea cycle R-HSA-70635 9.722741e-01 0.012 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.722741e-01 0.012 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.736739e-01 0.012 0 0
Signaling by BMP R-HSA-201451 9.760016e-01 0.011 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.760016e-01 0.011 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.760016e-01 0.011 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.760016e-01 0.011 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.760016e-01 0.011 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.760016e-01 0.011 0 0
Aquaporin-mediated transport R-HSA-445717 9.763069e-01 0.010 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.763871e-01 0.010 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.763871e-01 0.010 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.763871e-01 0.010 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 9.763871e-01 0.010 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.763871e-01 0.010 0 0
Choline catabolism R-HSA-6798163 9.763871e-01 0.010 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.768173e-01 0.010 0 0
Regulation of insulin secretion R-HSA-422356 9.772360e-01 0.010 0 0
Phospholipid metabolism R-HSA-1483257 9.780972e-01 0.010 0 0
COPII-mediated vesicle transport R-HSA-204005 9.781762e-01 0.010 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.791912e-01 0.009 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.792419e-01 0.009 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.792419e-01 0.009 0 0
Metabolism of folate and pterines R-HSA-196757 9.796546e-01 0.009 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.800000e-01 0.009 0 0
PKA activation in glucagon signalling R-HSA-164378 9.800864e-01 0.009 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.800864e-01 0.009 0 0
Biosynthesis of DHA-derived sulfido conjugates R-HSA-9026395 9.800864e-01 0.009 0 0
Metabolism of porphyrins R-HSA-189445 9.802865e-01 0.009 0 0
Complex I biogenesis R-HSA-6799198 9.808561e-01 0.008 0 0
Protein localization R-HSA-9609507 9.813958e-01 0.008 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.820562e-01 0.008 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.820562e-01 0.008 0 0
Glucagon-type ligand receptors R-HSA-420092 9.820562e-01 0.008 0 0
Purine salvage R-HSA-74217 9.821587e-01 0.008 0 0
Leishmania phagocytosis R-HSA-9664417 9.822387e-01 0.008 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.822387e-01 0.008 0 0
Parasite infection R-HSA-9664407 9.822387e-01 0.008 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.832064e-01 0.007 0 0
Specification of the neural plate border R-HSA-9834899 9.832064e-01 0.007 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.832064e-01 0.007 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.832064e-01 0.007 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.843663e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.844984e-01 0.007 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.848091e-01 0.007 0 0
Metal ion SLC transporters R-HSA-425410 9.855628e-01 0.006 0 0
Synthesis of PA R-HSA-1483166 9.856352e-01 0.006 0 0
Keratan sulfate degradation R-HSA-2022857 9.858377e-01 0.006 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.858377e-01 0.006 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.858377e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.861765e-01 0.006 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.863107e-01 0.006 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.866160e-01 0.006 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.872066e-01 0.006 0 0
Kidney development R-HSA-9830369 9.876167e-01 0.005 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.879856e-01 0.005 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.880568e-01 0.005 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.880568e-01 0.005 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.880568e-01 0.005 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.880568e-01 0.005 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.880568e-01 0.005 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.884507e-01 0.005 0 0
HS-GAG degradation R-HSA-2024096 9.884507e-01 0.005 0 0
Peroxisomal protein import R-HSA-9033241 9.886145e-01 0.005 0 0
Disease R-HSA-1643685 9.887103e-01 0.005 1 0
Azathioprine ADME R-HSA-9748787 9.887281e-01 0.005 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.894552e-01 0.005 0 0
Translation of Structural Proteins R-HSA-9683701 9.895258e-01 0.005 0 0
CS-GAG biosynthesis R-HSA-2022870 9.899284e-01 0.004 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.899284e-01 0.004 0 0
Serine metabolism R-HSA-977347 9.899284e-01 0.004 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.900392e-01 0.004 0 0
Complex IV assembly R-HSA-9864848 9.900507e-01 0.004 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.905798e-01 0.004 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.914135e-01 0.004 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.914135e-01 0.004 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.914877e-01 0.004 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.915067e-01 0.004 0 0
Fructose metabolism R-HSA-5652084 9.915067e-01 0.004 0 0
Ethanol oxidation R-HSA-71384 9.915067e-01 0.004 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.915067e-01 0.004 0 0
Pyruvate metabolism R-HSA-70268 9.919660e-01 0.004 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.922644e-01 0.003 0 0
Nucleotide biosynthesis R-HSA-8956320 9.922644e-01 0.003 0 0
RA biosynthesis pathway R-HSA-5365859 9.926019e-01 0.003 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.926019e-01 0.003 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.926019e-01 0.003 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.926019e-01 0.003 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.928378e-01 0.003 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.928378e-01 0.003 0 0
Formation of the ureteric bud R-HSA-9830674 9.928378e-01 0.003 0 0
Biosynthesis of maresins R-HSA-9018682 9.928378e-01 0.003 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.928946e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.930237e-01 0.003 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.936287e-01 0.003 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.937093e-01 0.003 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.939603e-01 0.003 0 0
Complex III assembly R-HSA-9865881 9.939603e-01 0.003 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.939603e-01 0.003 0 0
Paracetamol ADME R-HSA-9753281 9.940011e-01 0.003 0 0
HS-GAG biosynthesis R-HSA-2022928 9.945155e-01 0.002 0 0
Triglyceride catabolism R-HSA-163560 9.945155e-01 0.002 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.949069e-01 0.002 0 0
Laminin interactions R-HSA-3000157 9.949069e-01 0.002 0 0
Collagen chain trimerization R-HSA-8948216 9.952808e-01 0.002 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.957053e-01 0.002 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.957053e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.958736e-01 0.002 0 0
Leishmania infection R-HSA-9658195 9.958736e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.959411e-01 0.002 0 0
GPER1 signaling R-HSA-9634597 9.959752e-01 0.002 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.961397e-01 0.002 0 0
Triglyceride biosynthesis R-HSA-75109 9.963785e-01 0.002 0 0
Synthesis of PE R-HSA-1483213 9.963785e-01 0.002 0 0
Pentose phosphate pathway R-HSA-71336 9.965103e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.965103e-01 0.002 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.967840e-01 0.001 0 0
Insulin receptor recycling R-HSA-77387 9.969462e-01 0.001 0 0
Prednisone ADME R-HSA-9757110 9.969462e-01 0.001 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.969462e-01 0.001 0 0
Pyrimidine salvage R-HSA-73614 9.969462e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.969526e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.970062e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.972418e-01 0.001 0 0
Maturation of spike protein R-HSA-9694548 9.974234e-01 0.001 0 0
Thyroxine biosynthesis R-HSA-209968 9.974250e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.975257e-01 0.001 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.977873e-01 0.001 0 0
Activation of GABAB receptors R-HSA-991365 9.981003e-01 0.001 0 0
GABA B receptor activation R-HSA-977444 9.981003e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.981003e-01 0.001 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.981691e-01 0.001 0 0
Iron uptake and transport R-HSA-917937 9.983829e-01 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.984178e-01 0.001 0 0
DAG1 glycosylations R-HSA-8931838 9.984562e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.984781e-01 0.001 1 0
Neddylation R-HSA-8951664 9.984891e-01 0.001 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.984970e-01 0.001 0 0
Methylation R-HSA-156581 9.986013e-01 0.001 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.986983e-01 0.001 0 0
Keratan sulfate biosynthesis R-HSA-2022854 9.986983e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9694635 9.987454e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.987472e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.987556e-01 0.001 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.988003e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.988658e-01 0.000 0 0
CS/DS degradation R-HSA-2024101 9.989024e-01 0.000 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.989024e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.991183e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.991481e-01 0.000 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.991481e-01 0.000 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.991694e-01 0.000 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.992197e-01 0.000 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.992197e-01 0.000 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.992197e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.993069e-01 0.000 0 0
Glycosphingolipid transport R-HSA-9845576 9.993421e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.993527e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.993527e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.993611e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.993611e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.993670e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.994296e-01 0.000 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.994453e-01 0.000 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.994453e-01 0.000 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.994453e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.995902e-01 0.000 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.996057e-01 0.000 0 0
Tryptophan catabolism R-HSA-71240 9.996675e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.997100e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.997146e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.997197e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.997224e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997327e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.997547e-01 0.000 1 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.997691e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.998129e-01 0.000 0 0
Pyrimidine catabolism R-HSA-73621 9.998320e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.998460e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998514e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.998585e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.998640e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.998640e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.998837e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998894e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998906e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999213e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999245e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999286e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999312e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999312e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999371e-01 0.000 0 0
Keratan sulfate/keratin metabolism R-HSA-1638074 9.999397e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999474e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999476e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999543e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999560e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.999571e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.999615e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.999615e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999664e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999664e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.999710e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999715e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999715e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.999743e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999748e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.999782e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.999784e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999788e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999796e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.999796e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999796e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.999796e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999799e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999818e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999852e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999874e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999874e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999900e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999908e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999926e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999926e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999933e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.999953e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999955e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999975e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999984e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999995e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999996e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999996e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999996e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999997e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999998e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999999e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 1.000000e+00 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways