AKT3

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O14617 S658 Sugiyama AP3D1 PRO0039 DERPRAVFHEEEQRRPKHRPsEADEEELARRREARKQEQAN
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O15013 S1287 Sugiyama ARHGEF10 KIAA0294 WLGDSLGSMTQKsDLssssGsLsLsHGsssLEHRSEDsTIy
O15027 S1193 Sugiyama SEC16A KIAA0310 SEC16 SEC16L YsLPYPPEPGAASLYYQDVYsLYEPRYRPyDGAASAYAQNY
O15111 T23 SIGNOR CHUK IKKA TCF16 RPPGLRPGAGGPWEMRERLGtGGFGNVCLYQHRELDLKIAI
O15119 S719 SIGNOR|EPSD|PSP TBX3 LSsssMsLsPKLCAEKEAATsELQsIQRLVSGLEAKPDRsR
O43175 T78 Sugiyama PHGDH PGDH3 KVTADVINAAEKLQVVGRAGtGVDNVDLEAAtRKGILVMNT
O43524 S253 SIGNOR FOXO3 FKHRL1 FOXO3A WWIINPDGGKsGKAPRRRAVsMDNsNKYTKSRGRAAKKKAA
O43524 S315 SIGNOR FOXO3 FKHRL1 FOXO3A PtSRssDELDAWTDFRsRTNsNAsTVsGRLSPIMAsTELDE
O43524 T32 SIGNOR FOXO3 FKHRL1 FOXO3A sPLEVELDPEFEPQSRPRsCtWPLQRPELQAsPAKPSGETA
O43707 T69 Sugiyama ACTN4 EKQQRKTFTAWCNsHLRKAGtQIENIDEDFRDGLKLMLLLE
O43847 S94 Sugiyama NRDC NRD1 ENSRVARLGADEsEEEGRRGsLsNAGDPEIVKsPsDPKQYR
O60271 T595 Sugiyama SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 NLKYNAPTSHVtPsVKKRsstLsQLPGDKSKAFDFLSEETE
O60343 S751 Sugiyama TBC1D4 AS160 KIAA0603 EIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRRIS
O60814 S37 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60841 S182 Sugiyama EIF5B IF2 KIAA0741 DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O75348 S68 Sugiyama ATP6V1G1 ATP6G ATP6G1 ATP6J RLQREKEFKAKEAAALGsRGsCstEVEKETQEKMTILQtyF
O75494 S133 Sugiyama SRSF10 FUSIP1 FUSIP2 SFRS13A TASR yDRYRRSRSRSYERRRsRsRsFDyNYRRsYsPRNSRPTGRP
O75533 T125 Sugiyama SF3B1 SAP155 AEHRPPKIADREDEYKKHRRtMIIsPERLDPFADGGKtPDP
O75665 S899 Sugiyama OFD1 CXorf5 EEKIREQQVKERRQREERRQsNLQEVLERERRELEKLyQER
O75937 S81 Sugiyama DNAJC8 SPF31 HSPC315 HSPC331 VLQIDPEVTDEEIKKRFRQLsILVHPDKNQDDADRAQKAFE
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95425 S673 Sugiyama SVIL ERFRtQPITSAERKESDRCtsHsEtPTVDDEEKVDERAKLS
O95453 S557 Sugiyama PARN DAN KRLNPQCIPYTLQNHYYRNNsFtAPstVGKRNLsPsQEEAG
O95757 T637 Sugiyama HSPA4L APG1 HSPH3 OSP94 RNDAKNAVEEyVyDFRDRLGtVYEKFITPEDLSKLSAVLED
O95835 S464 Sugiyama LATS1 WARTS SPSSGHEIPTWQPNIPVRsNsFNNPLGNRASHSANSQPSAT
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00491 S176 Sugiyama PNP NP GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P04040 T434 Sugiyama CAT QQPSALEHSIQYSGEVRRFNtANDDNVtQVRAFyVNVLNEE
P04075 S176 Sugiyama ALDOA ALDA EHtPsALAIMENANVLARyAsICQQNGIVPIVEPEILPDGD
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T49 Sugiyama ALDOA ALDA GILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtADDR
P04792 S82 SIGNOR|Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05362 S43 Sugiyama ICAM1 GPGNAQTSVSPSKVILPRGGsVLVTCstsCDQPKLLGIETP
P05783 S93 Sugiyama KRT18 CYK18 PIG46 GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07814 S1336 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 SEEDKEALIAKCNDYRRRLLsVNIRVRADLRDNysPGWKFN
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08174 S106 Sugiyama CD55 CR DAF QWSDIEEFCNRSCEVPtRLNsAsLKQPYITQNyFPVGtVVE
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08670 S325 Sugiyama VIM NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P09972 S176 Sugiyama ALDOC ALDC ERTPSALAILENANVLARyAsICQQNGIVPIVEPEILPDGD
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13797 S339 Sugiyama PLS3 PRIDINMsGFNETDDLKRAEsMLQQADKLGCRQFVTPADVV
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14598 S304 PSP NCF1 NOXO2 SH3PXD1A GQDVsQAQRQIKRGAPPRRssIRNAHsIHQRsRKRLsQDAY
P14598 S328 PSP NCF1 NOXO2 SH3PXD1A AHsIHQRsRKRLsQDAYRRNsVRFLQQRRRQARPGPQsPGs
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P15056 S364 SIGNOR BRAF BRAF1 RAFB1 QPFRPADEDHRNQFGQRDRsssAPNVHINtIEPVNIDDLIR
P15056 S365 EPSD|PSP BRAF BRAF1 RAFB1 PFRPADEDHRNQFGQRDRsssAPNVHINtIEPVNIDDLIRD
P15056 S428 SIGNOR BRAF BRAF1 RAFB1 GSLTNVKALQKsPGPQRERKsssssEDRNRMKtLGRRDssD
P15056 S429 EPSD|PSP BRAF BRAF1 RAFB1 SLTNVKALQKsPGPQRERKsssssEDRNRMKtLGRRDssDD
P15104 S322 Sugiyama GLUL GLNS GFHETSNINDFSAGVANRsAsIRIPRTVGQEKKGYFEDRRP
P15880 S190 Sugiyama RPS2 RPS4 WGNKIGKPHTVPCKVTGRCGsVLVRLIPAPRGtGIVsAPVP
P16220 S119 SIGNOR CREB1 EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17655 T464 Sugiyama CAPN2 CANPL2 TNIHLSKNFFLTNRARERsDtFINLREVLNRFKLPPGEYIL
P18583 S1950 Sugiyama SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312 RSHTPSRRRRSRSVGRRRsFsIsPSRRSRTPSRRSRTPSRR
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P22087 S124 Sugiyama FBL FIB1 FLRN DALVTKNLVPGEsVyGEKRVsIsEGDDKIEyRAWNPFRSKL
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P25054 S1861 Sugiyama APC DP2.5 DsPHHytPIEGTPYCFsRNDsLssLDFDDDDVDLSREKAEL
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27708 S1859 Sugiyama CAD RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P27824 S362 Sugiyama CANX WDEDMDGEWEAPQIANPRCEsAPGCGVWQRPVIDNPNyKGK
P29474 S615 SIGNOR NOS3 GPYNSsPRPEQHKSYKIRFNsISCSDPLVssWRRKRKEssN
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P30043 T190 Sugiyama BLVRB FLR SCAN RGPSRVISKHDLGHFMLRCLttDEyDGHstyPsHQyQ____
P30086 S52 Sugiyama PEBP1 PBP PEBP AAVDELGKVLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPD
P31749 T312 Sugiyama AKT1 PKB RAC DFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGRAVDW
P31751 T313 Sugiyama AKT2 DFGLCKEGISDGATMKtFCGtPEyLAPEVLEDNDyGRAVDW
P32119 S112 Sugiyama PRDX2 NKEFB TDPX1 KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P35226 S316 SIGNOR BMI1 PCGF4 RNF51 TSNSPSGNHQSSFANRPRKSsVNGSSATSSG__________
P35240 S10 PSP NF2 SCH ___________MAGAIASRMsFssLKRKQPKTFTVRIVTMD
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35269 T156 Sugiyama GTF2F1 RAP74 EAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHFSI
P35580 S1937 Sugiyama MYH10 LSREVSTLKNRLRRGGPIsFsssRSGRRQLHLEGAsLELsD
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837 S13 Sugiyama TALDO1 TAL TALDO TALDOR ________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023 S265 Sugiyama RPL3 OK/SW-cl.32 HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P42677 T74 Sugiyama RPS27 MPS1 VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43243 S234 Sugiyama MATR3 KIAA0723 yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46779 S115 Sugiyama RPL28 HMIRKNKYRPDLRMAAIRRAsAILRSQKPVMVKRKRTRPTK
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P49419 S84 Sugiyama ALDH7A1 ATQ1 EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49750 S304 Sugiyama YLPM1 C14orf170 ZAP3 DPSTMTPQEQQQYWYRQHLLsLQQRTKVHLPGHKKGPVVAK
P49840 S41 Sugiyama GSK3A sFAEPGGGGGGGGGGPGGsAsGPGGTGGGKASVGAMGGGVG
P49840 Y279 Sugiyama GSK3A LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P49841 S9 SIGNOR GSK3B ____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P49841 Y216 Sugiyama GSK3B LKLCDFGSAKQLVRGEPNVsyICsRYYRAPELIFGATDYTS
P51816 S622 Sugiyama AFF2 FMR2 OX19 QKIPETKALKHKLSTTSETVsQRtIGKKQPKKVEKNTSTDE
P51816 T625 Sugiyama AFF2 FMR2 OX19 PETKALKHKLSTTSETVsQRtIGKKQPKKVEKNTSTDEFTW
P51946 T12 Sugiyama CCNH _________MYHNsSQKRHWtFSsEEQLARLRADANRKFRC
P52742 S308 Sugiyama ZNF135 ZNF61 ZNF78L1 HQRTHTGEKPYECSECGKSFsFRSSFSQHERTHTGEKPYEC
P53365 S260 Sugiyama ARFIP2 POR1 TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA
P53396 S455 Sugiyama ACLY ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53396 S656 Sugiyama ACLY IGNTGGMLDNILASKLyRPGsVAyVSRsGGMsNELNNIISR
P55036 S358 Sugiyama PSMD4 MCB1 VLENLPGVDPNNEAIRNAMGsLAsQATKDGKKDKKEEDKK_
P55083 T248 Sugiyama MFAP4 SYANGINWAQWKGFYYSLKRtEMKIRRA_____________
P55196 S216 Sugiyama AFDN AF6 MLLT4 SRLAAEVYKDMPETSFTRtIsNPEVVMKRRRQQKLEKRMQE
P55211 S196 SIGNOR CASP9 MCH6 GLRTRTGsNIDCEKLRRRFssLHFMVEVKGDLTAKKMVLAL
P55265 T1033 SIGNOR|PSP ADAR ADAR1 DSRAD G1P1 IFI4 VESSDIVPTWDGIRLGERLRtMSCSDKILRWNVLGLQGALL
P57053 S37 Sugiyama H2BC12L H2BFS H2BS1 KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876 S37 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P61313 S100 Sugiyama RPL15 EC45 TCBAP0781 tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 S74 Sugiyama RPS11 tyIDKKCPFTGNVsIRGRILsGVVTKMKMQRTIVIRRDYLH
P62753 S235 Sugiyama RPS6 OK/SW-cl.2 KRMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK______
P62753 S236 Sugiyama RPS6 OK/SW-cl.2 RMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK_______
P62807 S37 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62917 S14 Sugiyama RPL8 _______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68400 T13 Sugiyama CSNK2A1 CK2A1 ________MSGPVPSRARVytDVNTHRPREYWDYESHVVEW
P78362 S494 Sugiyama SRPK2 GSPLTEQEESSPSHDRSRtVsAsstGDLPKAKTRAADLLVN
P78563 T553 SIGNOR|PSP ADARB1 ADAR2 DRADA2 RED1 VRSNASIQTWDGVLQGERLLtMSCSDKIARWNVVGIQGSLL
P84098 S12 Sugiyama RPL19 _________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P99999 Y47 SIGNOR|PSP CYCS CYC HKTGPNLHGLFGRKtGQAPGysytAANKNKGIIWGEDTLME
Q00613 S230 PSP HSF1 HSTF1 PLMLNDsGsAHSMPKYSRQFsLEHVHGSGPYSAPSPAYSSS
Q01860 T235 SIGNOR POU5F1 OCT3 OCT4 OTF3 ENLQEICKAETLVQARKRKRtsIENRVRGNLENLFLQCPKP
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q07666 S20 Sugiyama KHDRBS1 SAM68 _MQRRDDPAARMsRssGRsGsMDPsGAHPsVRQtPsRQPPL
Q12931 T494 Sugiyama TRAP1 HSP75 HSPC5 ALPsGQLtsLsEyASRMRAGtRNIyyLCAPNRHLAEHsPyy
Q12965 T936 Sugiyama MYO1E MYO1C LQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAAP
Q12982 S114 Sugiyama BNIP2 NIP2 EFEWEDDLPKPKTTEVIRKGsItEyTAAEEKEDGRRWRMFR
Q13043 T387 SIGNOR STK4 KRS2 MST1 tMVINAEDEEEEGtMKRRDEtMQPAKPsFLEyFEQKEKENQ
Q13188 T117 SIGNOR STK3 KRS1 MST2 IVMEYCGAGSVSDIIRLRNKtLIEDEIATILKSTLKGLEYL
Q13247 S297 Sugiyama SRSF6 SFRS6 SRP55 RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q13247 S301 Sugiyama SRSF6 SFRS6 SRP55 PKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKR
Q13442 S176 Sugiyama PDAP1 HASPP28 KKEEERKAKDDATLsGKRMQsLsLNK_______________
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13610 S485 Sugiyama PWP1 SVNEAFGRRERLVLGSARNssISGPFGsRssDTPMES____
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14653 S385 PSP IRF3 VKVVPTCLRALVEMARVGGAssLENtVDLHIsNsHPLsLts
Q14671 S709 Sugiyama PUM1 KIAA0099 PUMH1 LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14676 T447 Sugiyama MDC1 KIAA0170 NFBD1 WNRDAEEDMPQRVVLLQRsQtttERDsDtDVEEEELPVENR
Q14847 S146 Sugiyama LASP1 MLN50 FEKSRMGPsGGEGMEPERRDsQDGssyRRPLEQQQPHHIPt
Q15149 S4386 Sugiyama PLEC PLEC1 ItEFADMLsGNAGGFRsRsssVGssssyPIsPAVsRtQLAs
Q15428 S153 Sugiyama SF3A2 SAP62 LFQIDYPEIAEGIMPRHRFMsAyEQRIEPPDRRWQYLLMAA
Q15642 S296 Sugiyama TRIP10 CIP4 STOT STP FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15818 S91 Sugiyama NPTX1 TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP
Q16763 T152 Sugiyama UBE2S E2EPF OK/SW-cl.73 EAGRLLLENyEEyAARARLLtEIHGGAGGPSGRAEAGRALA
Q5QNW6 S37 Sugiyama H2BC18 HIST2H2BF KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5SW79 S466 Sugiyama CEP170 FAM68A KAB KIAA0470 sEEPsVsIPFLQTALLRssGsLGHRPSQEMDKMLKNQAtsA
Q5SW79 S881 Sugiyama CEP170 FAM68A KAB KIAA0470 sstPssLALtsAsRIRERsEsLDPDssMDTtLILKDTEAVM
Q5SYE7 S1495 Sugiyama NHSL1 C6orf63 KIAA1357 KNRRAQEEWAKNEGLMPRsLsFsGPRYGRSRTPPSAASSRY
Q5T0N5 S489 Sugiyama FNBP1L C1orf39 TOCA1 EAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytDD
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6GYQ0 S797 Sugiyama RALGAPA1 GARNL1 KIAA0884 TULIP1 EtGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDM
Q6PJG9 S585 Sugiyama LRFN4 SALM3 sPTPKAHPPRsPPPRPQRsCsLDLGDAGCYGYARRLGGAWA
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71RC2 S392 Sugiyama LARP4 PP13296 KNRVKPQFRssGGsEHstEGsVsLGDGQLNRYSSRNFPAER
Q71UM5 T74 Sugiyama RPS27L VLCVGCSTVLCQPTGGKARLtEGCsFRRKQH__________
Q7L2J0 S152 Sugiyama MEPCE BCDIN3 PRNGYQPHRPPGGGGGKRRNsCNVGGGGGGFKHPAFKRRRR
Q7Z4V5 S454 Sugiyama HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604 VRPEEKQQAKPVKVERTRKRsEGFsMDRKVEKKKEPSVEEK
Q7Z589 S209 PSP EMSY C11orf30 GL002 VKSVSCsDEDEKPRKRRRtNsssssPVVLKEVPKAVVPVSK
Q7Z589 T207 PSP EMSY C11orf30 GL002 VYVKSVSCsDEDEKPRKRRRtNsssssPVVLKEVPKAVVPV
Q7Z5L9 S455 Sugiyama IRF2BP2 AGGSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVG
Q7Z5L9 S457 Sugiyama IRF2BP2 GSHASKDANQVHSTTRRNsNsPPsPssMNQRRLGPREVGGQ
Q86UU0 S118 Sugiyama BCL9L DLNB11 QAGVPPFssLKGKVKRDRsVsVDsGEQREAGtPsLDSEAKE
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q8IWX8 S904 Sugiyama CHERP DAN26 SCAF6 KGVGVALDDPyENyRRNKsysFIARMKARDECK________
Q8IZ21 S590 Sugiyama PHACTR4 PRO2963 SKEEWNEIRHQIGNTLIRRLsQRPtPEELEQRNILQPKNEA
Q8NBJ7 S256 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NBK3 T372 Sugiyama SUMF1 PSEC0152 UNQ3037/PRO9852 NTPDSsAsNLGFRCAADRLPtMD__________________
Q8ND56 T384 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A DKTKsFFDNIsCDDNRERRPtWAEERRLNAETFGIPLRPNR
Q8TB72 S587 Sugiyama PUM2 KIAA0235 PUMH2 LSGFGSSVGSSASSSATRREsLstsSDLYKRSSSSLAPIGQ
Q8TD19 T333 Sugiyama NEK9 KIAA1995 NEK8 NERCC REMEEKVTLLNAPTKRPRsstVtEAPIAVVTSRTSEVYVWG
Q8TE77 S37 Sugiyama SSH3 SSH3L tPVGPWDQAVQRRSRLQRRQsFAVLRGAVLGLQDGGDNDDA
Q8TEW0 S837 Sugiyama PARD3 PAR3 PAR3A AFQREGFGRQsMsEKRtKQFsDAsQLDFVKTRKsKsMDLGI
Q8WUX9 T408 Sugiyama CHMP7 LQDTTKEPLDLPDNPRNRHFtNsVPNPRIsDAELEAELEKL
Q8WWI1 T932 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 VtPRPFGsQtRGISsLPRsYtMDDAWKYNGDVEDIKRtPNN
Q8WWL2 S476 Sugiyama SPIRE2 KIAA1832 SPIR2 GLQSATHPPGGTEPPRPRAGsAHVWRPGSRDQGTCPASVSD
Q8WX93 S726 Sugiyama PALLD KIAA0992 CGI-151 PAsPEPMSALASRsAPAMQssGsFNyARPKQFIAAQNLGPA
Q8WX93 S728 Sugiyama PALLD KIAA0992 CGI-151 sPEPMSALASRsAPAMQssGsFNyARPKQFIAAQNLGPAsG
Q92597 S326 Sugiyama NDRG1 CAP43 DRG1 RTP KYFVQGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHt
Q92597 S330 Sugiyama NDRG1 CAP43 DRG1 RTP QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92597 S364 Sugiyama NDRG1 CAP43 DRG1 RTP sHtSEGTRsRsHtsEGtRsRsHtsEGAHLDItPNsGAAGNs
Q92597 S367 Sugiyama NDRG1 CAP43 DRG1 RTP SEGTRsRsHtsEGtRsRsHtsEGAHLDItPNsGAAGNsAGP
Q92597 T366 Sugiyama NDRG1 CAP43 DRG1 RTP tSEGTRsRsHtsEGtRsRsHtsEGAHLDItPNsGAAGNsAG
Q92766 S1167 Sugiyama RREB1 FINB AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q92900 T151 SIGNOR|PSP UPF1 KIAA0221 RENT1 PACVVYCNTSKKWFCNGRGNtSGSHIVNHLVRAKCKEVTLH
Q92934 S118 SIGNOR BAD BBC6 BCL2L8 RsAPPNLWAAQRYGRELRRMsDEFVDsFKKGLPRPKsAGtA
Q92934 S99 SIGNOR BAD BBC6 BCL2L8 GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q92945 S193 Sugiyama KHSRP FUBP2 DSGCKVQIsPDsGGLPERsVsLtGAPEsVQKAKMMLDDIVS
Q93079 S37 Sugiyama H2BC9 H2BFJ HIST1H2BH KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q96G46 S236 Sugiyama DUS3L QQLRKREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPR
Q96G46 T240 Sugiyama DUS3L KREVRFERAEQALRRFsQGPtPAAAVPEGTAAEGAPRQENC
Q96PK6 S520 Sugiyama RBM14 SIP AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q96ST2 S720 SIGNOR|PSP IWS1 IWS1L TREEREQRDLEQMPQRRRMNstGGQtPRRDLEKVLTGEEKA
Q96ST2 T721 SIGNOR|PSP IWS1 IWS1L REEREQRDLEQMPQRRRMNstGGQtPRRDLEKVLTGEEKAL
Q99613 S754 Sugiyama EIF3C EIF3S8 REHVVAASKAMKMGDWKTCHsFIINEKMNGKVWDLFPEADK
Q99877 S37 Sugiyama H2BC15 H2BFD HIST1H2BN KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879 S37 Sugiyama H2BC14 H2BFE HIST1H2BM KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880 S37 Sugiyama H2BC13 H2BFC HIST1H2BL KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q9BW19 T157 Sugiyama KIFC1 HSET KNSL2 WDLKGQLCDLNAELKRCRERtQtLDQENQQLQDQLRDAQQQ
Q9BW19 T159 Sugiyama KIFC1 HSET KNSL2 LKGQLCDLNAELKRCRERtQtLDQENQQLQDQLRDAQQQVK
Q9BW71 S357 Sugiyama HIRIP3 EDsGKGEPTAKGSRKMARLGstsGEEsDLEREVsDsEAGGG
Q9BY44 S526 Sugiyama EIF2A CDA02 MSTP004 MSTP089 sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BZL6 S200 Sugiyama PRKD2 PKD2 HSPC187 CAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPCTAE
Q9BZL6 T199 Sugiyama PRKD2 PKD2 HSPC187 RCAFsIPNNCsGARKRRLsstsLAsGHsVRLGtsEsLPCTA
Q9C0C2 S429 Sugiyama TNKS1BP1 KIAA1741 TAB182 EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9H0B6 S428 Sugiyama KLC2 NKPIWMHAEEREESKDKRRDsAPyGEyGsWYKACKVDsPtV
Q9H1K0 S548 Sugiyama RBSN ZFYVE20 RELEREREQFRVASLHTRTRsLDFREIGPFQLEPSREPRTH
Q9H3Z4 S10 Sugiyama DNAJC5 CLN4 ___________MADQRQRsLstsGEsLyHVLGLDKNATSDD
Q9NP61 S366 Sugiyama ARFGAP3 ARFGAP1 DDsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKD
Q9NP61 S367 Sugiyama ARFGAP3 ARFGAP1 DsyFTSSSSYFDEPVELRsssFssWDDssDSyWKKETSKDT
Q9NPQ8 T441 Sugiyama RIC8A AARGLMAGGRPEGQysEDEDtDtDEyKEAKAsINPVTGRVE
Q9NRA8 S353 Sugiyama EIF4ENIF1 SASRFSRWFSNPsRsGsRsssLGstPHEELERLAGLEQAIL
Q9NVN8 S513 Sugiyama GNL3L PNRHQMGWAKRNVDHRPKsNsMVDVCsVDRRSVLQRIMETD
Q9NYF8 Y322 Sugiyama BCLAF1 BTF KIAA0164 AKtIAPQNAPRDEsRGRssFyPDGGDQETAKtGKFLKRFtD
Q9NZN8 S157 Sugiyama CNOT2 CDC36 NOT2 HSPC131 MSTP046 RNMMNHSQVGQGIGIPSRtNsMsssGLGsPNRssPsIICMP
Q9NZQ3 S256 Sugiyama NCKIPSD AF3P21 SPIN90 GSSCSPtPPPVPRRGtHTTVsQVQPPPSKASAPEPPAEEEV
Q9P2T1 S37 Sugiyama GMPR2 LRPKRSTLKsRsEVDLTRSFsFRNSKQTYSGVPIIAANMDT
Q9UBP6 S27 Sugiyama METTL1 C12orf1 NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGV2 S327 Sugiyama NDRG3 KYFLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsV
Q9UGV2 S331 Sugiyama NDRG3 QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2 T329 Sugiyama NDRG3 FLQGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVts
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKV8 S387 SIGNOR|EPSD|PSP|Sugiyama AGO2 EIF2C2 ATARSAPDRQEEISKLMRsAsFNTDPyVREFGIMVKDEMTD
Q9ULD2 S199 Sugiyama MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1 GKsQsFHtAGSLPPTGRRsGstsSLSySTWTSSHSDKTHAR
Q9ULL1 S615 Sugiyama PLEKHG1 KIAA1209 STETSSSGHRIVRRAssAGEsNtCPPEIGTSDRTRELQNSP
Q9UNH7 S316 Sugiyama SNX6 LKYYLRESQAAKDLLYRRsRsLVDYENANKALDKARAKNKD
Q9UPU9 S168 Sugiyama SAMD4A KIAA1053 SAMD4 SMAUG1 NHLEDRTSTSFGGQNRGRsDsVDYGQTHYYHQRQNsDDKLN
Q9UQ35 S1455 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 PsRRsRsGssPGLRDGsGtPsRHsLsGssPGMKDIPRtPSR
Q9UQ35 S1539 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ35 S992 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sssPDtKVKPEtPPRQsHsGsIsPyPKVKAQtPPGPsLsGs
Q9Y243 S120 Sugiyama AKT3 PKBG EAIQAVADRLQRQEEERMNCsPtsQIDNIGEEEMDAsTtHH
Q9Y243 S123 Sugiyama AKT3 PKBG QAVADRLQRQEEERMNCsPtsQIDNIGEEEMDAsTtHHKRK
Q9Y243 S136 Sugiyama AKT3 PKBG RMNCsPtsQIDNIGEEEMDAsTtHHKRKTMNDFDYLKLLGK
Q9Y243 S472 Sugiyama AKT3 PKBG YDEDGMDCMDNERRPHFPQFsysAsGRE_____________
Q9Y243 S474 Sugiyama AKT3 PKBG EDGMDCMDNERRPHFPQFsysAsGRE_______________
Q9Y243 S476 Sugiyama AKT3 PKBG GMDCMDNERRPHFPQFsysAsGRE_________________
Q9Y243 T122 Sugiyama AKT3 PKBG IQAVADRLQRQEEERMNCsPtsQIDNIGEEEMDAsTtHHKR
Q9Y243 T138 Sugiyama AKT3 PKBG NCsPtsQIDNIGEEEMDAsTtHHKRKTMNDFDYLKLLGKGT
Q9Y243 T193 Sugiyama AKT3 PKBG YYAMKILKKEVIIAKDEVAHtLtESRVLKNTRHPFLTSLKY
Q9Y243 T195 Sugiyama AKT3 PKBG AMKILKKEVIIAKDEVAHtLtESRVLKNTRHPFLTSLKYSF
Q9Y243 T309 Sugiyama AKT3 PKBG DFGLCKEGITDAATMKtFCGtPEyLAPEVLEDNDyGRAVDW
Q9Y243 Y473 Sugiyama AKT3 PKBG DEDGMDCMDNERRPHFPQFsysAsGRE______________
Q9Y2V2 T50 Sugiyama CARHSP1 sPsPLRGNVVPsPLPtRRtRtFsAtVRASQGPVYKGVCKCF
Q9Y580 S136 Sugiyama RBM7 RyERTMDNMTSSAQIIQRsFssPENFQRQAVMNsALRQMSY
Q9Y5U2 S86 Sugiyama TSSC4 PSPPSGLLPATVQPFHLRGMssTFSQRsRDIFDCLEGAARR
Q9Y5U2 S87 Sugiyama TSSC4 SPPSGLLPATVQPFHLRGMssTFSQRsRDIFDCLEGAARRA
Q9Y6D5 S277 Sugiyama ARFGEF2 ARFGEP2 BIG2 RSDSGKVSTENGDAPRERGssLsGtDDGAQEVVKDILEDVV
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 2.990749e-08 7.524 1 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.262098e-08 7.279 1 1
Chromatin modifying enzymes R-HSA-3247509 1.148544e-07 6.940 0 0
NRAGE signals death through JNK R-HSA-193648 2.107444e-07 6.676 0 0
G alpha (12/13) signalling events R-HSA-416482 3.460836e-07 6.461 0 0
Chromatin organization R-HSA-4839726 4.440552e-07 6.353 0 0
Cell Cycle R-HSA-1640170 7.298699e-07 6.137 1 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.133334e-07 6.090 0 0
Cellular Senescence R-HSA-2559583 1.098700e-06 5.959 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.182770e-06 5.927 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.532482e-06 5.815 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.129578e-06 5.505 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.644558e-06 5.438 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.406114e-06 5.267 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.714882e-06 5.173 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.709718e-06 5.173 0 0
Axon guidance R-HSA-422475 8.155747e-06 5.089 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.000160e-05 5.000 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.035004e-05 4.985 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.153076e-05 4.938 0 0
Apoptotic execution phase R-HSA-75153 1.188511e-05 4.925 0 0
Death Receptor Signaling R-HSA-73887 1.586370e-05 4.800 0 0
Cell Cycle Checkpoints R-HSA-69620 1.662812e-05 4.779 0 0
RNA Polymerase II Transcription R-HSA-73857 1.977147e-05 4.704 1 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.924049e-05 4.716 1 0
PKMTs methylate histone lysines R-HSA-3214841 2.124574e-05 4.673 0 0
Cell Cycle, Mitotic R-HSA-69278 2.504949e-05 4.601 1 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.767376e-05 4.558 0 0
Nervous system development R-HSA-9675108 3.330586e-05 4.477 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 3.589472e-05 4.445 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.704035e-05 4.431 0 0
Gene expression (Transcription) R-HSA-74160 4.294474e-05 4.367 1 0
Generic Transcription Pathway R-HSA-212436 4.755970e-05 4.323 1 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.720461e-05 4.326 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.066002e-05 4.295 1 0
G2/M DNA damage checkpoint R-HSA-69473 5.266496e-05 4.278 0 0
Meiotic synapsis R-HSA-1221632 7.035847e-05 4.153 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 7.035847e-05 4.153 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.002121e-04 3.999 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.044984e-04 3.981 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.109163e-04 3.955 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.517231e-04 3.819 1 0
DNA methylation R-HSA-5334118 1.605149e-04 3.794 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.570179e-04 3.804 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.608303e-04 3.794 0 0
Meiosis R-HSA-1500620 1.687762e-04 3.773 0 0
Rap1 signalling R-HSA-392517 1.800862e-04 3.745 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.829934e-04 3.738 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.932165e-04 3.714 0 0
HATs acetylate histones R-HSA-3214847 2.433629e-04 3.614 0 0
Reproduction R-HSA-1474165 2.502378e-04 3.602 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.651906e-04 3.576 0 0
Packaging Of Telomere Ends R-HSA-171306 2.888244e-04 3.539 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 2.888244e-04 3.539 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.326681e-04 3.478 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.788572e-04 3.422 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.794655e-04 3.421 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.000090e-04 3.398 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.286146e-04 3.368 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.907973e-04 3.309 1 1
Regulation of TP53 Activity R-HSA-5633007 4.737818e-04 3.324 1 0
DNA Double Strand Break Response R-HSA-5693606 4.789949e-04 3.320 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.158361e-04 3.287 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.523884e-04 3.258 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.791079e-04 3.237 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.791079e-04 3.237 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.943768e-04 3.226 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.553745e-04 3.184 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.553745e-04 3.184 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 8.099278e-04 3.092 0 0
M Phase R-HSA-68886 7.907799e-04 3.102 0 0
Mitotic Prophase R-HSA-68875 7.848610e-04 3.105 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.089810e-04 3.092 0 0
Meiotic recombination R-HSA-912446 8.129110e-04 3.090 0 0
PIP3 activates AKT signaling R-HSA-1257604 8.558964e-04 3.068 1 1
Cell junction organization R-HSA-446728 8.948665e-04 3.048 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 9.314489e-04 3.031 1 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.469959e-04 3.024 0 0
Processing of DNA double-strand break ends R-HSA-5693607 9.583870e-04 3.018 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.112541e-03 2.954 0 0
Homology Directed Repair R-HSA-5693538 1.175999e-03 2.930 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.199910e-03 2.921 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 1.430511e-03 2.845 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.492744e-03 2.826 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.556595e-03 2.808 1 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.647360e-03 2.783 1 1
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.661405e-03 2.780 0 0
HDACs deacetylate histones R-HSA-3214815 1.700594e-03 2.769 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.743209e-03 2.759 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.808411e-03 2.743 0 0
G2/M Checkpoints R-HSA-69481 1.994159e-03 2.700 0 0
Signaling by ROBO receptors R-HSA-376176 2.232966e-03 2.651 0 0
ESR-mediated signaling R-HSA-8939211 2.252258e-03 2.647 1 0
DNA Double-Strand Break Repair R-HSA-5693532 2.282717e-03 2.642 0 0
Regulation of TP53 Expression R-HSA-6804754 2.528386e-03 2.597 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 2.564741e-03 2.591 0 0
Diseases of programmed cell death R-HSA-9645723 2.950953e-03 2.530 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.958605e-03 2.529 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.966389e-03 2.528 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 3.056637e-03 2.515 0 0
RET signaling R-HSA-8853659 3.366400e-03 2.473 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.831653e-03 2.417 1 1
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.807384e-03 2.419 0 0
Cell-Cell communication R-HSA-1500931 3.807997e-03 2.419 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 4.101759e-03 2.387 0 0
Cleavage of the damaged purine R-HSA-110331 4.101759e-03 2.387 0 0
Cell-cell junction organization R-HSA-421270 4.141949e-03 2.383 0 0
Signaling by Hippo R-HSA-2028269 4.178118e-03 2.379 0 0
Specification of primordial germ cells R-HSA-9827857 4.178118e-03 2.379 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.786772e-03 2.320 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.786772e-03 2.320 0 0
HDMs demethylate histones R-HSA-3214842 4.739993e-03 2.324 0 0
Sema4D in semaphorin signaling R-HSA-400685 4.739993e-03 2.324 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.786772e-03 2.320 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.148428e-03 2.288 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.148428e-03 2.288 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.148428e-03 2.288 0 0
Post NMDA receptor activation events R-HSA-438064 5.071304e-03 2.295 0 0
Signaling by VEGF R-HSA-194138 5.148428e-03 2.288 1 0
Adherens junctions interactions R-HSA-418990 5.039911e-03 2.298 0 0
Depurination R-HSA-73927 4.962418e-03 2.304 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.147581e-03 2.288 0 0
Depyrimidination R-HSA-73928 5.147581e-03 2.288 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.528724e-03 2.257 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.592132e-03 2.252 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.695311e-03 2.244 0 0
Cell-extracellular matrix interactions R-HSA-446353 5.695311e-03 2.244 0 0
Defective pyroptosis R-HSA-9710421 6.116867e-03 2.213 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.194084e-03 2.143 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.193969e-03 2.143 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.227822e-03 2.141 0 0
Regulation of TP53 Degradation R-HSA-6804757 8.271485e-03 2.082 1 1
CREB phosphorylation R-HSA-199920 9.012277e-03 2.045 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.494440e-03 2.071 0 0
Nucleosome assembly R-HSA-774815 8.494440e-03 2.071 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.678723e-03 2.062 0 0
Signaling by WNT R-HSA-195721 8.369627e-03 2.077 0 0
DAG and IP3 signaling R-HSA-1489509 8.494440e-03 2.071 0 0
Ub-specific processing proteases R-HSA-5689880 8.724463e-03 2.059 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.586460e-03 2.018 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.862263e-03 2.006 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.931207e-03 2.003 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.931207e-03 2.003 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.931207e-03 2.003 0 0
Ion homeostasis R-HSA-5578775 9.585779e-03 2.018 0 0
Signaling by RAS mutants R-HSA-6802949 9.931207e-03 2.003 0 0
Signaling by RAF1 mutants R-HSA-9656223 9.963841e-03 2.002 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.998818e-03 2.000 0 0
EPH-Ephrin signaling R-HSA-2682334 1.011706e-02 1.995 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.031425e-02 1.987 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.031425e-02 1.987 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.031425e-02 1.987 0 0
DARPP-32 events R-HSA-180024 1.107239e-02 1.956 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.131887e-02 1.946 0 0
Signaling by NTRKs R-HSA-166520 1.140589e-02 1.943 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.163678e-02 1.934 0 0
FOXO-mediated transcription R-HSA-9614085 1.302013e-02 1.885 1 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.396201e-02 1.855 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.468741e-02 1.833 1 0
TRP channels R-HSA-3295583 1.550381e-02 1.810 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.566214e-02 1.805 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.618125e-02 1.791 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.716780e-02 1.765 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.716780e-02 1.765 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.716780e-02 1.765 0 0
NrCAM interactions R-HSA-447038 1.716780e-02 1.765 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 1.881528e-02 1.725 0 0
Activation of RAC1 R-HSA-428540 1.949848e-02 1.710 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.815749e-02 1.741 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.755986e-02 1.755 0 0
Calmodulin induced events R-HSA-111933 1.900420e-02 1.721 0 0
CaM pathway R-HSA-111997 1.900420e-02 1.721 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.886637e-02 1.724 0 0
Deubiquitination R-HSA-5688426 1.768397e-02 1.752 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.892348e-02 1.723 1 0
Assembly of the pre-replicative complex R-HSA-68867 1.990375e-02 1.701 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.051081e-02 1.688 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.081960e-02 1.682 0 0
MAP2K and MAPK activation R-HSA-5674135 2.166324e-02 1.664 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.217947e-02 1.654 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.269870e-02 1.644 0 0
Neurexins and neuroligins R-HSA-6794361 2.297559e-02 1.639 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 2.316742e-02 1.635 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.316742e-02 1.635 0 0
Semaphorin interactions R-HSA-373755 2.340277e-02 1.631 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.632876e-02 1.580 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.632876e-02 1.580 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.632876e-02 1.580 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 2.632876e-02 1.580 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.526063e-02 1.598 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.506173e-02 1.601 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.506173e-02 1.601 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.459769e-02 1.609 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.573031e-02 1.590 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.422099e-02 1.616 0 0
Signaling by LTK R-HSA-9842663 2.564715e-02 1.591 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.626790e-02 1.581 0 0
Developmental Biology R-HSA-1266738 2.437749e-02 1.613 1 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.632876e-02 1.580 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.411731e-02 1.618 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.724125e-02 1.565 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.751763e-02 1.560 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.933207e-02 1.533 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 2.937865e-02 1.532 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.967911e-02 1.528 0 0
RAF activation R-HSA-5673000 3.060456e-02 1.514 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.076544e-02 1.512 0 0
Telomere Maintenance R-HSA-157579 3.152363e-02 1.501 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.197413e-02 1.495 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.197413e-02 1.495 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.197413e-02 1.495 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.197413e-02 1.495 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.197413e-02 1.495 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.197413e-02 1.495 0 0
Apoptosis R-HSA-109581 3.207930e-02 1.494 1 0
mRNA Splicing - Major Pathway R-HSA-72163 3.679638e-02 1.434 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.642146e-02 1.439 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.530990e-02 1.452 1 1
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.588014e-02 1.445 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.449670e-02 1.462 1 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.296520e-02 1.482 0 0
PLC beta mediated events R-HSA-112043 3.476230e-02 1.459 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.642146e-02 1.439 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.693317e-02 1.433 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.385650e-02 1.470 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.704019e-02 1.431 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.740215e-02 1.427 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.740215e-02 1.427 0 0
Muscle contraction R-HSA-397014 3.742299e-02 1.427 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.793604e-02 1.421 0 0
Cardiac conduction R-HSA-5576891 4.074972e-02 1.390 0 0
Chromosome Maintenance R-HSA-73886 4.099469e-02 1.387 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.151653e-02 1.382 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.227995e-02 1.374 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.293730e-02 1.367 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.293730e-02 1.367 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.351524e-02 1.361 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.351524e-02 1.361 0 0
PKA activation R-HSA-163615 4.368548e-02 1.360 0 0
PKA activation in glucagon signalling R-HSA-164378 4.368548e-02 1.360 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.368548e-02 1.360 0 0
Polo-like kinase mediated events R-HSA-156711 4.368548e-02 1.360 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.412162e-02 1.355 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.424878e-02 1.354 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.204306e-02 1.284 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.204306e-02 1.284 0 0
Regulation of PTEN localization R-HSA-8948747 5.204306e-02 1.284 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.134713e-02 1.289 0 0
Integrin signaling R-HSA-354192 4.870219e-02 1.312 0 0
Centrosome maturation R-HSA-380287 4.529375e-02 1.344 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.141090e-02 1.289 0 0
Mitotic Prometaphase R-HSA-68877 4.974635e-02 1.303 0 0
Dopamine receptors R-HSA-390651 5.199133e-02 1.284 0 0
MTOR signalling R-HSA-165159 4.985870e-02 1.302 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 4.687034e-02 1.329 1 0
G2/M Transition R-HSA-69275 4.773566e-02 1.321 0 0
Ca-dependent events R-HSA-111996 4.985870e-02 1.302 0 0
MECP2 regulates transcription factors R-HSA-9022707 5.204306e-02 1.284 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.860538e-02 1.313 0 0
Specification of the neural plate border R-HSA-9834899 5.250825e-02 1.280 0 0
DNA Repair R-HSA-73894 5.271273e-02 1.278 0 0
MAPK family signaling cascades R-HSA-5683057 5.276297e-02 1.278 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.343634e-02 1.272 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.349176e-02 1.272 1 1
DNA Replication Pre-Initiation R-HSA-69002 5.537226e-02 1.257 0 0
Opioid Signalling R-HSA-111885 5.552761e-02 1.255 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 5.858540e-02 1.232 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.858540e-02 1.232 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.989558e-02 1.223 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.989558e-02 1.223 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.989558e-02 1.223 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.081746e-02 1.216 0 0
Neurodegenerative Diseases R-HSA-8863678 6.081746e-02 1.216 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.577817e-02 1.182 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 6.577817e-02 1.182 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 6.577817e-02 1.182 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.422084e-02 1.129 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.422084e-02 1.129 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.422084e-02 1.129 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.422084e-02 1.129 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.422084e-02 1.129 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.422084e-02 1.129 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.237325e-02 1.205 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.047001e-02 1.152 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.047001e-02 1.152 0 0
mRNA Splicing R-HSA-72172 6.723523e-02 1.172 0 0
Formation of definitive endoderm R-HSA-9823730 6.237325e-02 1.205 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.162224e-02 1.145 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.342946e-02 1.198 0 0
Netrin-1 signaling R-HSA-373752 6.281645e-02 1.202 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.371862e-02 1.132 0 0
Signalling to ERKs R-HSA-187687 7.176220e-02 1.144 0 0
G-protein mediated events R-HSA-112040 6.322217e-02 1.199 0 0
Long-term potentiation R-HSA-9620244 7.047001e-02 1.152 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 7.479463e-02 1.126 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.097551e-02 1.149 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.862617e-02 1.164 0 0
PI Metabolism R-HSA-1483255 7.462390e-02 1.127 0 0
L1CAM interactions R-HSA-373760 6.782083e-02 1.169 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.009674e-02 1.154 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.009674e-02 1.154 0 0
Signaling by Interleukins R-HSA-449147 6.797088e-02 1.168 0 0
Interleukin-37 signaling R-HSA-9008059 6.707153e-02 1.173 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.630884e-02 1.178 0 0
Amyloid fiber formation R-HSA-977225 7.595388e-02 1.119 0 0
mRNA 3'-end processing R-HSA-72187 7.965441e-02 1.099 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.214070e-02 1.085 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.226781e-02 1.085 0 0
Negative regulation of MAPK pathway R-HSA-5675221 8.388916e-02 1.076 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 8.527187e-02 1.069 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 8.527187e-02 1.069 0 0
Recycling pathway of L1 R-HSA-437239 8.610393e-02 1.065 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 8.759538e-02 1.058 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 8.759538e-02 1.058 0 0
Frs2-mediated activation R-HSA-170968 9.023814e-02 1.045 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 9.242211e-02 1.034 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.311087e-02 1.031 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.431904e-02 1.025 0 0
NGF-stimulated transcription R-HSA-9031628 9.491692e-02 1.023 0 0
Co-stimulation by CD28 R-HSA-389356 9.491692e-02 1.023 1 0
RNA Polymerase I Transcription R-HSA-73864 9.616042e-02 1.017 0 0
Programmed Cell Death R-HSA-5357801 9.624215e-02 1.017 1 0
Kinesins R-HSA-983189 9.661265e-02 1.015 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 9.736017e-02 1.012 0 0
Cardiogenesis R-HSA-9733709 9.736017e-02 1.012 0 0
Hedgehog 'off' state R-HSA-5610787 9.905106e-02 1.004 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.012291e-01 0.995 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.012291e-01 0.995 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.012291e-01 0.995 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.012291e-01 0.995 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.012291e-01 0.995 0 0
Drug resistance of KIT mutants R-HSA-9669937 1.293802e-01 0.888 0 0
KIT mutants bind TKIs R-HSA-9669921 1.293802e-01 0.888 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 1.293802e-01 0.888 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 1.293802e-01 0.888 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 1.293802e-01 0.888 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.293802e-01 0.888 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.293802e-01 0.888 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.293802e-01 0.888 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 1.293802e-01 0.888 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 1.293802e-01 0.888 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 1.293802e-01 0.888 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.293802e-01 0.888 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 1.293802e-01 0.888 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.070396e-01 0.970 0 0
C6 deamination of adenosine R-HSA-75102 1.070396e-01 0.970 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.070396e-01 0.970 0 0
Potassium transport channels R-HSA-1296067 1.070396e-01 0.970 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.078858e-01 0.967 0 0
cGMP effects R-HSA-418457 1.078858e-01 0.967 0 0
DCC mediated attractive signaling R-HSA-418885 1.270773e-01 0.896 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 1.270773e-01 0.896 0 0
Ephrin signaling R-HSA-3928664 1.037342e-01 0.984 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.200090e-01 0.921 0 0
Interleukin receptor SHC signaling R-HSA-912526 1.123514e-01 0.949 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.116873e-01 0.952 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.051192e-01 0.978 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.281245e-01 0.892 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.248462e-01 0.904 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.037342e-01 0.984 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.242799e-01 0.906 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.234414e-01 0.909 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.037342e-01 0.984 0 0
Signal attenuation R-HSA-74749 1.088062e-01 0.963 0 0
p75NTR signals via NF-kB R-HSA-193639 1.270773e-01 0.896 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.037342e-01 0.984 0 0
RMTs methylate histone arginines R-HSA-3214858 1.133114e-01 0.946 0 0
Regulation of CDH11 function R-HSA-9762292 1.088062e-01 0.963 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 1.200090e-01 0.921 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.223581e-01 0.912 0 0
Mitotic Anaphase R-HSA-68882 1.173210e-01 0.931 0 0
HDL assembly R-HSA-8963896 1.078858e-01 0.967 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.273011e-01 0.895 0 0
Platelet calcium homeostasis R-HSA-418360 1.178636e-01 0.929 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.088062e-01 0.963 0 0
Neuronal System R-HSA-112316 1.159280e-01 0.936 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.154872e-01 0.937 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.270773e-01 0.896 1 1
Protein ubiquitination R-HSA-8852135 1.210899e-01 0.917 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.037342e-01 0.984 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.107374e-01 0.956 0 0
Signaling by ALK in cancer R-HSA-9700206 1.107374e-01 0.956 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.307944e-01 0.883 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.318500e-01 0.880 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.318500e-01 0.880 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.320715e-01 0.879 0 0
Signaling by APC mutants R-HSA-4839744 1.320715e-01 0.879 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.320715e-01 0.879 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.320715e-01 0.879 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.320715e-01 0.879 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.339970e-01 0.873 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.345481e-01 0.871 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.354061e-01 0.868 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.355544e-01 0.868 1 1
FLT3 Signaling R-HSA-9607240 1.355544e-01 0.868 1 1
Signaling by TGFBR3 R-HSA-9839373 1.358149e-01 0.867 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.374632e-01 0.862 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.374632e-01 0.862 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.374632e-01 0.862 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.374632e-01 0.862 0 0
TGFBR3 expression R-HSA-9839394 1.434093e-01 0.843 0 0
Formation of the nephric duct R-HSA-9830364 1.434093e-01 0.843 0 0
Interleukin-7 signaling R-HSA-1266695 1.434093e-01 0.843 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.420277e-01 0.616 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.420277e-01 0.616 0 0
Defective SLC2A10 causes arterial tortuosity syndrome (ATS) R-HSA-5619068 2.420277e-01 0.616 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.420277e-01 0.616 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.420277e-01 0.616 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.420277e-01 0.616 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.420277e-01 0.616 0 0
Defective SLC26A4 causes Pendred syndrome (PDS) R-HSA-5619046 2.420277e-01 0.616 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 1.532646e-01 0.815 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.532646e-01 0.815 0 0
Invadopodia formation R-HSA-8941237 1.532646e-01 0.815 0 0
HCN channels R-HSA-1296061 2.024794e-01 0.694 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.024794e-01 0.694 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.024794e-01 0.694 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.024794e-01 0.694 1 1
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.024794e-01 0.694 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.024794e-01 0.694 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.024794e-01 0.694 0 0
PI and PC transport between ER and Golgi membranes R-HSA-1483196 3.401057e-01 0.468 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.401057e-01 0.468 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 3.401057e-01 0.468 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 3.401057e-01 0.468 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.401057e-01 0.468 0 0
Intestinal infectious diseases R-HSA-8942233 3.401057e-01 0.468 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.401057e-01 0.468 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 3.401057e-01 0.468 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.401057e-01 0.468 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 3.401057e-01 0.468 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.401057e-01 0.468 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.401057e-01 0.468 0 0
IKBKB deficiency causes SCID R-HSA-5602636 3.401057e-01 0.468 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.401057e-01 0.468 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.401057e-01 0.468 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.401057e-01 0.468 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.401057e-01 0.468 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.401057e-01 0.468 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.401057e-01 0.468 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.401057e-01 0.468 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.401057e-01 0.468 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 3.401057e-01 0.468 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.401057e-01 0.468 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.401057e-01 0.468 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.401057e-01 0.468 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.629527e-01 0.788 0 0
Ca2+ activated K+ channels R-HSA-1296052 1.629527e-01 0.788 0 0
SOS-mediated signalling R-HSA-112412 1.629527e-01 0.788 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.629527e-01 0.788 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.629527e-01 0.788 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.531375e-01 0.597 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.531375e-01 0.597 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.531375e-01 0.597 0 0
IRS activation R-HSA-74713 2.531375e-01 0.597 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.531375e-01 0.597 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 1.971606e-01 0.705 0 0
RSK activation R-HSA-444257 1.971606e-01 0.705 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.971606e-01 0.705 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.971606e-01 0.705 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 1.477048e-01 0.831 0 0
Differentiation of T cells R-HSA-9945266 1.477048e-01 0.831 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.477048e-01 0.831 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.838702e-01 0.735 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.838702e-01 0.735 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.838702e-01 0.735 0 0
Lipophagy R-HSA-9613354 2.328913e-01 0.633 0 0
ALK mutants bind TKIs R-HSA-9700645 2.328913e-01 0.633 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.040423e-01 0.517 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.040423e-01 0.517 0 0
Signaling by MAPK mutants R-HSA-9652817 3.040423e-01 0.517 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.254978e-01 0.371 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.254978e-01 0.371 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.254978e-01 0.371 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.254978e-01 0.371 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.254978e-01 0.371 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.254978e-01 0.371 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.254978e-01 0.371 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.254978e-01 0.371 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.254978e-01 0.371 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.254978e-01 0.371 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.254978e-01 0.371 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.254978e-01 0.371 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 4.254978e-01 0.371 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.254978e-01 0.371 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.254978e-01 0.371 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.254978e-01 0.371 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.254978e-01 0.371 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.254978e-01 0.371 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 2.119123e-01 0.674 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.119123e-01 0.674 1 1
Formation of axial mesoderm R-HSA-9796292 2.119123e-01 0.674 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.119123e-01 0.674 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.119123e-01 0.674 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.119123e-01 0.674 0 0
PI3K/AKT activation R-HSA-198203 2.696501e-01 0.569 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.696501e-01 0.569 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 2.696501e-01 0.569 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 2.696501e-01 0.569 0 0
Regulation of KIT signaling R-HSA-1433559 2.410434e-01 0.618 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.542822e-01 0.451 0 0
Trafficking of AMPA receptors R-HSA-399719 1.466432e-01 0.834 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.069834e-01 0.513 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 3.069834e-01 0.513 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.780918e-01 0.749 0 0
Erythropoietin activates RAS R-HSA-9027284 2.710100e-01 0.567 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.710100e-01 0.567 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.710100e-01 0.567 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.710100e-01 0.567 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.710100e-01 0.567 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.175223e-01 0.662 1 1
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.785023e-01 0.748 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.618871e-01 0.791 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.954806e-01 0.709 0 0
Signaling by Erythropoietin R-HSA-9006335 2.159233e-01 0.666 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.159233e-01 0.666 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.676299e-01 0.572 1 1
Phosphorylation of the APC/C R-HSA-176412 3.015664e-01 0.521 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.015664e-01 0.521 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.444850e-01 0.463 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 3.444850e-01 0.463 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.444850e-01 0.463 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 4.031774e-01 0.395 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.031774e-01 0.395 0 0
Netrin mediated repulsion signals R-HSA-418886 4.031774e-01 0.395 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 4.031774e-01 0.395 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.031774e-01 0.395 0 0
Axonal growth stimulation R-HSA-209563 4.998442e-01 0.301 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 4.998442e-01 0.301 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.998442e-01 0.301 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.998442e-01 0.301 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.998442e-01 0.301 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 4.998442e-01 0.301 0 0
Defective ABCA1 causes TGD R-HSA-5682113 4.998442e-01 0.301 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.998442e-01 0.301 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.130920e-01 0.671 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.130920e-01 0.671 0 0
Tight junction interactions R-HSA-420029 2.623795e-01 0.581 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.623795e-01 0.581 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.939181e-01 0.532 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.565263e-01 0.805 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.324790e-01 0.478 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.324790e-01 0.478 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.324790e-01 0.478 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.856511e-01 0.544 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.817976e-01 0.418 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.817976e-01 0.418 0 0
IRAK1 recruits IKK complex R-HSA-937039 3.817976e-01 0.418 0 0
Polymerase switching R-HSA-69091 3.817976e-01 0.418 0 0
Leading Strand Synthesis R-HSA-69109 3.817976e-01 0.418 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.817976e-01 0.418 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 3.817976e-01 0.418 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.620648e-01 0.790 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.773270e-01 0.557 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.435763e-01 0.613 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.159848e-01 0.666 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.093411e-01 0.510 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.635288e-01 0.439 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.502349e-01 0.347 0 0
Type I hemidesmosome assembly R-HSA-446107 4.502349e-01 0.347 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.502349e-01 0.347 0 0
Formation of annular gap junctions R-HSA-196025 4.502349e-01 0.347 0 0
Activation of RAS in B cells R-HSA-1169092 4.502349e-01 0.347 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.502349e-01 0.347 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.309615e-01 0.636 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.309615e-01 0.636 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.716343e-01 0.765 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.186132e-01 0.378 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.970005e-01 0.706 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.204575e-01 0.494 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.945143e-01 0.404 0 0
Late endosomal microautophagy R-HSA-9615710 3.575523e-01 0.447 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.575523e-01 0.447 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.424416e-01 0.465 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 3.288410e-01 0.483 0 0
HSF1-dependent transactivation R-HSA-3371571 3.050183e-01 0.516 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.063600e-01 0.685 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.063600e-01 0.685 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.818684e-01 0.418 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.818684e-01 0.418 0 0
Deadenylation of mRNA R-HSA-429947 4.017101e-01 0.396 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.951118e-01 0.305 0 0
WNT mediated activation of DVL R-HSA-201688 4.951118e-01 0.305 0 0
Gap junction degradation R-HSA-190873 4.951118e-01 0.305 0 0
MTF1 activates gene expression R-HSA-5660489 5.645732e-01 0.248 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.645732e-01 0.248 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 5.645732e-01 0.248 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.645732e-01 0.248 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 5.645732e-01 0.248 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.645732e-01 0.248 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.645732e-01 0.248 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.645732e-01 0.248 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.697931e-01 0.432 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.697931e-01 0.432 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.092104e-01 0.510 0 0
Voltage gated Potassium channels R-HSA-1296072 4.091352e-01 0.388 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.897582e-01 0.310 0 0
SHC1 events in EGFR signaling R-HSA-180336 4.897582e-01 0.310 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 4.897582e-01 0.310 0 0
Regulation of CDH1 Function R-HSA-9764561 4.133131e-01 0.384 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.545189e-01 0.342 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 4.853516e-01 0.314 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.853516e-01 0.314 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.853516e-01 0.314 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.375844e-01 0.270 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.375844e-01 0.270 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.534861e-01 0.343 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.534861e-01 0.343 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 4.816171e-01 0.317 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 4.816171e-01 0.317 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.996578e-01 0.398 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 3.998310e-01 0.398 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.141039e-01 0.383 0 0
Striated Muscle Contraction R-HSA-390522 4.783511e-01 0.320 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.236990e-01 0.281 0 0
snRNP Assembly R-HSA-191859 4.498432e-01 0.347 0 0
Metabolism of non-coding RNA R-HSA-194441 4.498432e-01 0.347 0 0
HIV Transcription Elongation R-HSA-167169 4.754269e-01 0.323 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.754269e-01 0.323 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.754269e-01 0.323 0 0
Attenuation phase R-HSA-3371568 4.754269e-01 0.323 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.754269e-01 0.323 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.144438e-01 0.289 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.074794e-01 0.295 0 0
HIV elongation arrest and recovery R-HSA-167287 5.074794e-01 0.295 0 0
Pausing and recovery of HIV elongation R-HSA-167290 5.074794e-01 0.295 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 4.875555e-01 0.312 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.328079e-01 0.273 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.427501e-01 0.265 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.563588e-01 0.255 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 5.563588e-01 0.255 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.563588e-01 0.255 0 0
Phase 2 - plateau phase R-HSA-5576893 5.563588e-01 0.255 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.563588e-01 0.255 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.775236e-01 0.238 0 0
Cellular response to heat stress R-HSA-3371556 5.035941e-01 0.298 0 0
Degradation of CDH1 R-HSA-9766229 5.328106e-01 0.273 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.575301e-01 0.254 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 5.549445e-01 0.256 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.812592e-01 0.236 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 5.328079e-01 0.273 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 5.575301e-01 0.254 0 0
EGFR downregulation R-HSA-182971 5.815837e-01 0.235 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.860775e-01 0.413 1 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.138665e-01 0.383 0 0
Nucleotide Excision Repair R-HSA-5696398 4.549231e-01 0.342 0 0
IGF1R signaling cascade R-HSA-2428924 3.001553e-01 0.523 0 0
Signaling by EGFR R-HSA-177929 1.838743e-01 0.735 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.475718e-01 0.459 0 0
Signaling by FGFR4 R-HSA-5654743 4.111089e-01 0.386 0 0
Signaling by SCF-KIT R-HSA-1433557 4.111089e-01 0.386 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.575301e-01 0.254 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.175223e-01 0.662 1 1
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.332234e-01 0.632 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.091352e-01 0.388 0 0
Signaling by ERBB2 R-HSA-1227986 1.565263e-01 0.805 1 0
Telomere Extension By Telomerase R-HSA-171319 5.074794e-01 0.295 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.089789e-01 0.293 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.838702e-01 0.735 0 0
mRNA Editing R-HSA-75072 2.328913e-01 0.633 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.696434e-01 0.770 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.780918e-01 0.749 1 1
G0 and Early G1 R-HSA-1538133 1.622077e-01 0.790 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.194352e-01 0.659 0 0
Signaling by FGFR3 R-HSA-5654741 4.523260e-01 0.345 0 0
Separation of Sister Chromatids R-HSA-2467813 1.928227e-01 0.715 0 0
Signaling by FGFR1 R-HSA-5654736 5.269188e-01 0.278 0 0
Aggrephagy R-HSA-9646399 4.754269e-01 0.323 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.170640e-01 0.286 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.704535e-01 0.568 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.704535e-01 0.568 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.838743e-01 0.735 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.312823e-01 0.636 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.555796e-01 0.341 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.006446e-01 0.698 1 1
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.515701e-01 0.819 1 1
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 3.160094e-01 0.500 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.571727e-01 0.804 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.328913e-01 0.633 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 2.696501e-01 0.569 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.017101e-01 0.396 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.375844e-01 0.270 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 4.754269e-01 0.323 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.170640e-01 0.286 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.141637e-01 0.383 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.141637e-01 0.383 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 3.511642e-01 0.454 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.773270e-01 0.557 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.040423e-01 0.517 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.696501e-01 0.569 0 0
LGI-ADAM interactions R-HSA-5682910 3.069834e-01 0.513 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.776282e-01 0.750 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.031774e-01 0.395 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.130920e-01 0.671 0 0
Peptide chain elongation R-HSA-156902 3.701438e-01 0.432 0 0
Signalling to RAS R-HSA-167044 4.853516e-01 0.314 0 0
Formation of apoptosome R-HSA-111458 5.375844e-01 0.270 0 0
TNF signaling R-HSA-75893 3.950283e-01 0.403 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.651797e-01 0.782 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.575301e-01 0.254 1 0
Regulation of TNFR1 signaling R-HSA-5357905 3.353691e-01 0.474 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.187434e-01 0.497 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.328106e-01 0.273 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.112133e-01 0.291 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.954806e-01 0.709 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 2.379425e-01 0.624 1 1
Adrenoceptors R-HSA-390696 1.971606e-01 0.705 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 1.838702e-01 0.735 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.328913e-01 0.633 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 2.328913e-01 0.633 0 0
Signaling by WNT in cancer R-HSA-4791275 1.622077e-01 0.790 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.785023e-01 0.748 0 0
NF-kB is activated and signals survival R-HSA-209560 3.444850e-01 0.463 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.951118e-01 0.305 0 0
Regulation of gap junction activity R-HSA-191650 5.645732e-01 0.248 0 0
S Phase R-HSA-69242 1.714091e-01 0.766 1 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.159143e-01 0.666 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.122957e-01 0.385 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.563588e-01 0.255 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.553040e-01 0.342 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.327585e-01 0.273 0 0
Receptor Mediated Mitophagy R-HSA-8934903 2.696501e-01 0.569 0 0
ERK/MAPK targets R-HSA-198753 2.939181e-01 0.532 0 0
Repression of WNT target genes R-HSA-4641265 3.817976e-01 0.418 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.435763e-01 0.613 0 0
Apoptotic factor-mediated response R-HSA-111471 3.945143e-01 0.404 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 3.575523e-01 0.447 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.327585e-01 0.273 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.692305e-01 0.772 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.236990e-01 0.281 0 0
Generation of second messenger molecules R-HSA-202433 4.754269e-01 0.323 0 0
Cyclin D associated events in G1 R-HSA-69231 5.805569e-01 0.236 0 0
G1 Phase R-HSA-69236 5.805569e-01 0.236 0 0
GPER1 signaling R-HSA-9634597 1.605288e-01 0.794 0 0
Potassium Channels R-HSA-1296071 1.676260e-01 0.776 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.542429e-01 0.595 1 1
Prolonged ERK activation events R-HSA-169893 1.477048e-01 0.831 0 0
Integration of energy metabolism R-HSA-163685 1.724258e-01 0.763 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 5.517593e-01 0.258 0 0
Gastrulation R-HSA-9758941 4.562720e-01 0.341 0 0
TCR signaling R-HSA-202403 5.231865e-01 0.281 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.777787e-01 0.321 0 0
Signaling by Hedgehog R-HSA-5358351 3.200050e-01 0.495 0 0
Calcineurin activates NFAT R-HSA-2025928 2.328913e-01 0.633 0 0
Abacavir transmembrane transport R-HSA-2161517 3.542822e-01 0.451 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.502349e-01 0.347 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.502349e-01 0.347 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 4.502349e-01 0.347 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 4.502349e-01 0.347 0 0
Nuclear RNA decay R-HSA-9930044 2.987261e-01 0.525 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.987261e-01 0.525 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.204575e-01 0.494 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 4.286336e-01 0.368 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.545189e-01 0.342 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 4.523260e-01 0.345 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.998310e-01 0.398 0 0
Formation of the posterior neural plate R-HSA-9832991 5.775236e-01 0.238 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.280996e-01 0.368 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.453576e-01 0.462 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.777787e-01 0.321 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.164080e-01 0.287 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.048311e-01 0.297 1 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.096748e-01 0.293 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.511003e-01 0.346 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.908061e-01 0.309 0 0
Hedgehog 'on' state R-HSA-5632684 4.141637e-01 0.383 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.453576e-01 0.462 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.453576e-01 0.462 0 0
Triglyceride catabolism R-HSA-163560 5.476708e-01 0.261 0 0
DAP12 signaling R-HSA-2424491 5.575301e-01 0.254 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.785023e-01 0.748 1 1
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.204575e-01 0.494 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.164080e-01 0.287 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.324790e-01 0.478 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.618871e-01 0.791 0 0
Interleukin-2 signaling R-HSA-9020558 5.775236e-01 0.238 0 0
DNA Replication R-HSA-69306 2.118294e-01 0.674 0 0
mTORC1-mediated signalling R-HSA-166208 1.961499e-01 0.707 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.817976e-01 0.418 1 1
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 4.273407e-01 0.369 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.202388e-01 0.495 0 0
Membrane Trafficking R-HSA-199991 5.014390e-01 0.300 1 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.280452e-01 0.277 0 0
Interleukin-2 family signaling R-HSA-451927 2.095529e-01 0.679 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.710100e-01 0.567 1 1
G-protein beta:gamma signalling R-HSA-397795 1.785023e-01 0.748 1 0
Downregulation of ERBB4 signaling R-HSA-1253288 4.502349e-01 0.347 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.987261e-01 0.525 0 0
Rab regulation of trafficking R-HSA-9007101 2.104096e-01 0.677 1 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.645732e-01 0.248 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 4.960777e-01 0.304 0 0
Eukaryotic Translation Termination R-HSA-72764 5.020951e-01 0.299 0 0
Transmission across Chemical Synapses R-HSA-112315 5.504174e-01 0.259 0 0
Interleukin-1 family signaling R-HSA-446652 4.095619e-01 0.388 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.065486e-01 0.295 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.265602e-01 0.370 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.265602e-01 0.370 0 0
PTEN Regulation R-HSA-6807070 4.955788e-01 0.305 1 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 5.630712e-01 0.249 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.623795e-01 0.581 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.571727e-01 0.804 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 3.204575e-01 0.494 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.563588e-01 0.255 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.249902e-01 0.280 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 2.159233e-01 0.666 0 0
G1/S Transition R-HSA-69206 5.667581e-01 0.247 1 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 3.600975e-01 0.444 0 0
Effects of PIP2 hydrolysis R-HSA-114508 1.954806e-01 0.709 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.858588e-01 0.313 0 0
Metabolism of RNA R-HSA-8953854 4.604311e-01 0.337 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.217202e-01 0.283 0 0
Signaling by TGFB family members R-HSA-9006936 5.806421e-01 0.236 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.187434e-01 0.497 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 5.495903e-01 0.260 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.944208e-01 0.531 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 5.448289e-01 0.264 0 0
Selective autophagy R-HSA-9663891 4.752384e-01 0.323 0 0
Cellular responses to stress R-HSA-2262752 2.833090e-01 0.548 1 0
GPVI-mediated activation cascade R-HSA-114604 5.476708e-01 0.261 0 0
Ca2+ pathway R-HSA-4086398 5.667127e-01 0.247 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.785023e-01 0.748 0 0
Cellular responses to stimuli R-HSA-8953897 1.847447e-01 0.733 1 0
Inhibition of PKR R-HSA-169131 2.420277e-01 0.616 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 1.971606e-01 0.705 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.571727e-01 0.804 0 0
Signaling by AXIN mutants R-HSA-4839735 1.571727e-01 0.804 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 2.328913e-01 0.633 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.254978e-01 0.371 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.254978e-01 0.371 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.756191e-01 0.755 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.168928e-01 0.664 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.069834e-01 0.513 0 0
Bicarbonate transporters R-HSA-425381 3.069834e-01 0.513 0 0
The NLRP3 inflammasome R-HSA-844456 2.419029e-01 0.616 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.159233e-01 0.666 0 0
Phase 4 - resting membrane potential R-HSA-5576886 3.015664e-01 0.521 0 0
MET interacts with TNS proteins R-HSA-8875513 4.998442e-01 0.301 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.502349e-01 0.347 0 0
Co-stimulation by ICOS R-HSA-9927354 4.502349e-01 0.347 0 0
Unwinding of DNA R-HSA-176974 4.951118e-01 0.305 0 0
Alanine metabolism R-HSA-8964540 5.645732e-01 0.248 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.645732e-01 0.248 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.713892e-01 0.430 0 0
Cristae formation R-HSA-8949613 4.816171e-01 0.317 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.236990e-01 0.281 0 0
Disorders of Developmental Biology R-HSA-9675151 5.563588e-01 0.255 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.780891e-01 0.556 1 0
Signaling by ERBB4 R-HSA-1236394 2.527393e-01 0.597 0 0
Activation of BH3-only proteins R-HSA-114452 2.358464e-01 0.627 1 0
Regulation of insulin secretion R-HSA-422356 2.592421e-01 0.586 0 0
Signaling by PTK6 R-HSA-8848021 5.217202e-01 0.283 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.217202e-01 0.283 0 0
MAP kinase activation R-HSA-450294 2.540686e-01 0.595 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.523260e-01 0.345 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.492415e-01 0.457 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.074794e-01 0.295 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.392148e-01 0.621 1 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.838702e-01 0.735 0 0
Amine ligand-binding receptors R-HSA-375280 4.317573e-01 0.365 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.435582e-01 0.353 0 0
Downstream signal transduction R-HSA-186763 4.061949e-01 0.391 0 0
Smooth Muscle Contraction R-HSA-445355 4.703046e-01 0.328 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 2.328913e-01 0.633 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.756191e-01 0.755 0 0
Interleukin-17 signaling R-HSA-448424 3.975974e-01 0.401 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.563588e-01 0.255 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.698523e-01 0.244 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.206147e-01 0.494 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 2.987261e-01 0.525 0 0
RUNX2 regulates bone development R-HSA-8941326 3.868556e-01 0.412 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 2.531375e-01 0.597 0 0
Interleukin-1 processing R-HSA-448706 2.328913e-01 0.633 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.040423e-01 0.517 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.119123e-01 0.674 0 0
CHL1 interactions R-HSA-447041 4.031774e-01 0.395 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.635288e-01 0.439 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.475718e-01 0.459 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.951118e-01 0.305 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.951118e-01 0.305 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.951118e-01 0.305 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.645732e-01 0.248 0 0
Protein hydroxylation R-HSA-9629569 4.555796e-01 0.341 0 0
Heme signaling R-HSA-9707616 5.039844e-01 0.298 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.870764e-01 0.412 1 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.112434e-01 0.675 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.018637e-01 0.299 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 5.144438e-01 0.289 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.186132e-01 0.378 0 0
Stimuli-sensing channels R-HSA-2672351 1.686814e-01 0.773 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.553040e-01 0.342 0 0
Signaling by NOTCH R-HSA-157118 1.774538e-01 0.751 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.984095e-01 0.400 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.168928e-01 0.664 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.039723e-01 0.690 1 0
Co-inhibition by PD-1 R-HSA-389948 4.766054e-01 0.322 0 0
TBC/RABGAPs R-HSA-8854214 5.602999e-01 0.252 0 0
Interleukin-15 signaling R-HSA-8983432 3.817976e-01 0.418 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.634686e-01 0.249 0 0
Glycolysis R-HSA-70171 2.834848e-01 0.547 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.138609e-01 0.383 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.093411e-01 0.510 0 0
DSCAM interactions R-HSA-376172 4.254978e-01 0.371 0 0
Tandem pore domain potassium channels R-HSA-1296346 2.696501e-01 0.569 0 0
Synthesis of PI R-HSA-1483226 3.069834e-01 0.513 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.998442e-01 0.301 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.998442e-01 0.301 0 0
Alpha-defensins R-HSA-1462054 4.502349e-01 0.347 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.121526e-01 0.673 0 0
ARMS-mediated activation R-HSA-170984 4.951118e-01 0.305 0 0
NADE modulates death signalling R-HSA-205025 5.645732e-01 0.248 0 0
Sensory perception of sour taste R-HSA-9729555 5.645732e-01 0.248 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 4.853516e-01 0.314 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.375844e-01 0.270 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.328079e-01 0.273 1 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.563588e-01 0.255 0 0
Diseases of DNA repair R-HSA-9675135 3.353691e-01 0.474 0 0
Inflammasomes R-HSA-622312 5.074794e-01 0.295 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.575301e-01 0.254 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.419029e-01 0.616 0 0
Plasma lipoprotein assembly R-HSA-8963898 4.017101e-01 0.396 0 0
Signaling by ALK R-HSA-201556 1.933070e-01 0.714 0 0
Sensory processing of sound R-HSA-9659379 3.238489e-01 0.490 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.939181e-01 0.532 0 0
Histamine receptors R-HSA-390650 4.998442e-01 0.301 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.607233e-01 0.584 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.545189e-01 0.342 0 0
PECAM1 interactions R-HSA-210990 5.775236e-01 0.238 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.894766e-01 0.538 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 4.897582e-01 0.310 0 0
Formation of the anterior neural plate R-HSA-9823739 4.897582e-01 0.310 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.254978e-01 0.371 0 0
NADPH regeneration R-HSA-389542 3.542822e-01 0.451 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 4.031774e-01 0.395 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.998442e-01 0.301 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 4.998442e-01 0.301 0 0
Interleukin-18 signaling R-HSA-9012546 4.502349e-01 0.347 0 0
Sodium/Proton exchangers R-HSA-425986 4.502349e-01 0.347 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.645732e-01 0.248 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.950283e-01 0.403 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.553040e-01 0.342 0 0
Glucose metabolism R-HSA-70326 4.517993e-01 0.345 0 0
G1/S-Specific Transcription R-HSA-69205 5.476708e-01 0.261 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.710100e-01 0.567 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.189376e-01 0.660 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 3.945143e-01 0.404 0 0
Base Excision Repair R-HSA-73884 1.525052e-01 0.817 0 0
Interleukin-12 signaling R-HSA-9020591 3.825827e-01 0.417 0 0
Signaling by Leptin R-HSA-2586552 5.375844e-01 0.270 0 0
Interleukin-12 family signaling R-HSA-447115 5.699226e-01 0.244 0 0
Gene Silencing by RNA R-HSA-211000 3.865227e-01 0.413 0 0
Signaling by FGFR in disease R-HSA-1226099 5.828026e-01 0.234 0 0
Signaling by NOTCH4 R-HSA-9013694 5.828026e-01 0.234 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.835313e-01 0.234 0 0
Ion channel transport R-HSA-983712 5.863247e-01 0.232 0 0
Selenocysteine synthesis R-HSA-2408557 5.867938e-01 0.232 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 5.876361e-01 0.231 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.876361e-01 0.231 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.876361e-01 0.231 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.876361e-01 0.231 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.876361e-01 0.231 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.876361e-01 0.231 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.876361e-01 0.231 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.901040e-01 0.229 0 0
Kidney development R-HSA-9830369 5.903164e-01 0.229 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.939412e-01 0.226 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.966696e-01 0.224 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.966696e-01 0.224 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 5.966696e-01 0.224 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.966696e-01 0.224 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 5.966696e-01 0.224 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.986275e-01 0.223 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.987745e-01 0.223 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.987745e-01 0.223 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.987745e-01 0.223 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.987745e-01 0.223 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.987745e-01 0.223 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.003500e-01 0.222 0 0
DNA strand elongation R-HSA-69190 6.049166e-01 0.218 0 0
Stabilization of p53 R-HSA-69541 6.125388e-01 0.213 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.125388e-01 0.213 0 0
Viral mRNA Translation R-HSA-192823 6.136971e-01 0.212 0 0
Signaling by NOTCH1 R-HSA-1980143 6.141686e-01 0.212 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.148736e-01 0.211 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.148736e-01 0.211 0 0
ERKs are inactivated R-HSA-202670 6.148736e-01 0.211 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 6.148736e-01 0.211 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.148736e-01 0.211 0 0
Sodium/Calcium exchangers R-HSA-425561 6.148736e-01 0.211 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 6.158965e-01 0.210 0 0
Aquaporin-mediated transport R-HSA-445717 6.158965e-01 0.210 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.174598e-01 0.209 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.174598e-01 0.209 0 0
GAB1 signalosome R-HSA-180292 6.174598e-01 0.209 0 0
Mismatch Repair R-HSA-5358508 6.174598e-01 0.209 0 0
Tie2 Signaling R-HSA-210993 6.174598e-01 0.209 0 0
Autophagy R-HSA-9612973 6.174639e-01 0.209 0 0
Activation of AMPA receptors R-HSA-399710 6.209284e-01 0.207 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.209284e-01 0.207 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 6.209284e-01 0.207 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.209284e-01 0.207 0 0
Defective F9 activation R-HSA-9673221 6.209284e-01 0.207 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.209284e-01 0.207 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.209284e-01 0.207 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.209284e-01 0.207 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.209284e-01 0.207 0 0
Activation of AKT2 R-HSA-165158 6.209284e-01 0.207 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.209284e-01 0.207 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.209284e-01 0.207 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.209284e-01 0.207 0 0
Biosynthesis of DPAn-3-derived 13-series resolvins R-HSA-9026403 6.209284e-01 0.207 0 0
PTK6 Down-Regulation R-HSA-8849472 6.209284e-01 0.207 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.209284e-01 0.207 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.221556e-01 0.206 0 0
Translation initiation complex formation R-HSA-72649 6.263258e-01 0.203 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.263258e-01 0.203 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.274857e-01 0.202 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 6.329700e-01 0.199 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 6.329700e-01 0.199 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.329700e-01 0.199 0 0
Diseases of Immune System R-HSA-5260271 6.329700e-01 0.199 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.329700e-01 0.199 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.355996e-01 0.197 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.384230e-01 0.195 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.386530e-01 0.195 0 0
Adaptive Immune System R-HSA-1280218 6.397154e-01 0.194 1 0
Cellular response to chemical stress R-HSA-9711123 6.411052e-01 0.193 1 0
Signaling by NOTCH3 R-HSA-9012852 6.437675e-01 0.191 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 6.457848e-01 0.190 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 6.457848e-01 0.190 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.457848e-01 0.190 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.457848e-01 0.190 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.457848e-01 0.190 0 0
Other interleukin signaling R-HSA-449836 6.457848e-01 0.190 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.465992e-01 0.189 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.465992e-01 0.189 0 0
Metalloprotease DUBs R-HSA-5689901 6.465992e-01 0.189 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 6.492571e-01 0.188 0 0
GRB2 events in EGFR signaling R-HSA-179812 6.496356e-01 0.187 0 0
MET activates RAS signaling R-HSA-8851805 6.496356e-01 0.187 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.496356e-01 0.187 0 0
Pervasive developmental disorders R-HSA-9005895 6.496356e-01 0.187 0 0
Disorders of Nervous System Development R-HSA-9697154 6.496356e-01 0.187 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.496356e-01 0.187 0 0
Estrogen biosynthesis R-HSA-193144 6.496356e-01 0.187 0 0
Adipogenesis R-HSA-9843745 6.497754e-01 0.187 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.566527e-01 0.183 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.607367e-01 0.180 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.607367e-01 0.180 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 6.607367e-01 0.180 0 0
Insulin receptor signalling cascade R-HSA-74751 6.648914e-01 0.177 0 0
Platelet homeostasis R-HSA-418346 6.649152e-01 0.177 0 0
Cilium Assembly R-HSA-5617833 6.682531e-01 0.175 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.699720e-01 0.174 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.699720e-01 0.174 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.699720e-01 0.174 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.699720e-01 0.174 0 0
PKB-mediated events R-HSA-109703 6.699926e-01 0.174 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.699926e-01 0.174 0 0
PDE3B signalling R-HSA-165160 6.699926e-01 0.174 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.699926e-01 0.174 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.699926e-01 0.174 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.699926e-01 0.174 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.699926e-01 0.174 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 6.699926e-01 0.174 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.699926e-01 0.174 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.699926e-01 0.174 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.699926e-01 0.174 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.699926e-01 0.174 0 0
NGF-independant TRKA activation R-HSA-187024 6.699926e-01 0.174 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.699926e-01 0.174 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.699926e-01 0.174 0 0
Formation of the Editosome R-HSA-75094 6.699926e-01 0.174 0 0
Synthesis of PS R-HSA-1483101 6.699926e-01 0.174 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.699926e-01 0.174 0 0
Phosphorylation of Emi1 R-HSA-176417 6.699926e-01 0.174 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.699926e-01 0.174 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.699926e-01 0.174 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.699926e-01 0.174 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.699926e-01 0.174 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.699926e-01 0.174 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.699926e-01 0.174 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.699926e-01 0.174 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.702050e-01 0.174 0 0
Dual Incision in GG-NER R-HSA-5696400 6.702050e-01 0.174 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.702050e-01 0.174 0 0
Signaling by NOTCH2 R-HSA-1980145 6.702050e-01 0.174 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.718694e-01 0.173 0 0
Signaling by NODAL R-HSA-1181150 6.725889e-01 0.172 0 0
DNA Damage Bypass R-HSA-73893 6.743182e-01 0.171 0 0
IRS-mediated signalling R-HSA-112399 6.772172e-01 0.169 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.818538e-01 0.166 0 0
Adenylate cyclase activating pathway R-HSA-170660 6.818538e-01 0.166 0 0
FGFR1c ligand binding and activation R-HSA-190373 6.818538e-01 0.166 0 0
Processing of SMDT1 R-HSA-8949664 6.818538e-01 0.166 0 0
Maturation of nucleoprotein R-HSA-9683610 6.818538e-01 0.166 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.818538e-01 0.166 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 6.818538e-01 0.166 0 0
Interleukin-1 signaling R-HSA-9020702 6.852152e-01 0.164 0 0
Macroautophagy R-HSA-1632852 6.869042e-01 0.163 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 6.903111e-01 0.161 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 6.903111e-01 0.161 0 0
Oncogene Induced Senescence R-HSA-2559585 6.903111e-01 0.161 0 0
PI3K Cascade R-HSA-109704 6.914046e-01 0.160 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 6.922572e-01 0.160 0 0
Formation of the Early Elongation Complex R-HSA-113418 6.922572e-01 0.160 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 6.922572e-01 0.160 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.922572e-01 0.160 0 0
Pyroptosis R-HSA-5620971 6.922572e-01 0.160 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.930131e-01 0.159 0 0
Dual incision in TC-NER R-HSA-6782135 6.931961e-01 0.159 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.931961e-01 0.159 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.978690e-01 0.156 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.978690e-01 0.156 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.978690e-01 0.156 0 0
Lagging Strand Synthesis R-HSA-69186 6.978690e-01 0.156 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.978690e-01 0.156 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.978690e-01 0.156 0 0
MHC class II antigen presentation R-HSA-2132295 7.074640e-01 0.150 0 0
Extension of Telomeres R-HSA-180786 7.086634e-01 0.150 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.086634e-01 0.150 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.095645e-01 0.149 0 0
HSF1 activation R-HSA-3371511 7.095645e-01 0.149 0 0
RNA Polymerase III Transcription R-HSA-74158 7.095645e-01 0.149 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.095645e-01 0.149 0 0
FLT3 signaling in disease R-HSA-9682385 7.095645e-01 0.149 0 0
Removal of the Flap Intermediate R-HSA-69166 7.116042e-01 0.148 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.116042e-01 0.148 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.116042e-01 0.148 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.116042e-01 0.148 0 0
NRIF signals cell death from the nucleus R-HSA-205043 7.116042e-01 0.148 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.116042e-01 0.148 0 0
Physiological factors R-HSA-5578768 7.116042e-01 0.148 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.116042e-01 0.148 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.116042e-01 0.148 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 7.117697e-01 0.148 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.127088e-01 0.147 0 0
STAT5 Activation R-HSA-9645135 7.127088e-01 0.147 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.127088e-01 0.147 0 0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587 7.127088e-01 0.147 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 7.127088e-01 0.147 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 7.127088e-01 0.147 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 7.127088e-01 0.147 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.127088e-01 0.147 0 0
Neurofascin interactions R-HSA-447043 7.127088e-01 0.147 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.127088e-01 0.147 0 0
Leukotriene receptors R-HSA-391906 7.127088e-01 0.147 0 0
Lipid particle organization R-HSA-8964572 7.127088e-01 0.147 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.134486e-01 0.147 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.134486e-01 0.147 0 0
Cellular response to starvation R-HSA-9711097 7.140401e-01 0.146 0 0
Developmental Cell Lineages R-HSA-9734767 7.192818e-01 0.143 0 0
HCMV Early Events R-HSA-9609690 7.214872e-01 0.142 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.216382e-01 0.142 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.216382e-01 0.142 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.216382e-01 0.142 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.216382e-01 0.142 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.216382e-01 0.142 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.216382e-01 0.142 0 0
Transcription of the HIV genome R-HSA-167172 7.241493e-01 0.140 0 0
Mitochondrial biogenesis R-HSA-1592230 7.259309e-01 0.139 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.335488e-01 0.135 0 0
Activation of the pre-replicative complex R-HSA-68962 7.335488e-01 0.135 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.335488e-01 0.135 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 7.380355e-01 0.132 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.389859e-01 0.131 0 0
Translesion synthesis by REV1 R-HSA-110312 7.389859e-01 0.131 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 7.389859e-01 0.131 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 7.389859e-01 0.131 0 0
Processive synthesis on the lagging strand R-HSA-69183 7.389859e-01 0.131 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.389859e-01 0.131 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 7.389859e-01 0.131 0 0
p38MAPK events R-HSA-171007 7.389859e-01 0.131 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 7.389859e-01 0.131 0 0
Protein methylation R-HSA-8876725 7.389859e-01 0.131 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.390955e-01 0.131 1 1
Parasitic Infection Pathways R-HSA-9824443 7.397526e-01 0.131 0 0
Leishmania infection R-HSA-9658195 7.397526e-01 0.131 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.413762e-01 0.130 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.413762e-01 0.130 0 0
Signaling by KIT in disease R-HSA-9669938 7.439230e-01 0.128 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.439230e-01 0.128 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.439230e-01 0.128 0 0
Notch-HLH transcription pathway R-HSA-350054 7.439230e-01 0.128 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.439230e-01 0.128 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.439230e-01 0.128 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.439230e-01 0.128 0 0
MET promotes cell motility R-HSA-8875878 7.454993e-01 0.128 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.454993e-01 0.128 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.471396e-01 0.127 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.498980e-01 0.125 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.498980e-01 0.125 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.498980e-01 0.125 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.498980e-01 0.125 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.498980e-01 0.125 0 0
Disinhibition of SNARE formation R-HSA-114516 7.498980e-01 0.125 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.498980e-01 0.125 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.498980e-01 0.125 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.498980e-01 0.125 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 7.498980e-01 0.125 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 7.498980e-01 0.125 0 0
VLDL clearance R-HSA-8964046 7.498980e-01 0.125 0 0
Activation of TRKA receptors R-HSA-187015 7.498980e-01 0.125 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 7.498980e-01 0.125 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.498980e-01 0.125 0 0
Glycoprotein hormones R-HSA-209822 7.498980e-01 0.125 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.498980e-01 0.125 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.498980e-01 0.125 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 7.525686e-01 0.123 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 7.525686e-01 0.123 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.525686e-01 0.123 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.569884e-01 0.121 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.569884e-01 0.121 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.569884e-01 0.121 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 7.569884e-01 0.121 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.617027e-01 0.118 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.629252e-01 0.118 0 0
Translesion synthesis by POLI R-HSA-5656121 7.641134e-01 0.117 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.641134e-01 0.117 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 7.641134e-01 0.117 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.641134e-01 0.117 0 0
Killing mechanisms R-HSA-9664420 7.641134e-01 0.117 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 7.641134e-01 0.117 0 0
Regulation of BACH1 activity R-HSA-9708530 7.641134e-01 0.117 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.641134e-01 0.117 0 0
Formation of the ureteric bud R-HSA-9830674 7.647606e-01 0.116 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.647606e-01 0.116 0 0
Syndecan interactions R-HSA-3000170 7.647606e-01 0.116 0 0
Growth hormone receptor signaling R-HSA-982772 7.647606e-01 0.116 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.678781e-01 0.115 0 0
G alpha (s) signalling events R-HSA-418555 7.690992e-01 0.114 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.705253e-01 0.113 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.718983e-01 0.112 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.718983e-01 0.112 0 0
Signaling by FGFR2 R-HSA-5654738 7.747079e-01 0.111 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.747079e-01 0.111 0 0
Glycogen metabolism R-HSA-8982491 7.780359e-01 0.109 0 0
Ion transport by P-type ATPases R-HSA-936837 7.781496e-01 0.109 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.805326e-01 0.108 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.822750e-01 0.107 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.822750e-01 0.107 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.822750e-01 0.107 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.822750e-01 0.107 0 0
Interleukin-9 signaling R-HSA-8985947 7.822750e-01 0.107 0 0
Regulation by c-FLIP R-HSA-3371378 7.822750e-01 0.107 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.822750e-01 0.107 0 0
Dimerization of procaspase-8 R-HSA-69416 7.822750e-01 0.107 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.822750e-01 0.107 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.822750e-01 0.107 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.841970e-01 0.106 0 0
TNFs bind their physiological receptors R-HSA-5669034 7.841970e-01 0.106 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 7.871115e-01 0.104 0 0
Translesion synthesis by POLK R-HSA-5655862 7.871115e-01 0.104 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.871115e-01 0.104 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.871115e-01 0.104 0 0
Passive transport by Aquaporins R-HSA-432047 7.871115e-01 0.104 0 0
Synthesis of PG R-HSA-1483148 7.871115e-01 0.104 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 7.874422e-01 0.104 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.874422e-01 0.104 0 0
Switching of origins to a post-replicative state R-HSA-69052 7.878260e-01 0.104 0 0
Cellular response to hypoxia R-HSA-1234174 7.904739e-01 0.102 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.930581e-01 0.101 0 0
Maturation of spike protein R-HSA-9694548 7.930581e-01 0.101 0 0
Platelet activation, signaling and aggregation R-HSA-76002 7.938191e-01 0.100 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.944188e-01 0.100 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.960158e-01 0.099 1 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.022845e-01 0.096 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.022845e-01 0.096 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.033469e-01 0.095 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.033469e-01 0.095 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.072722e-01 0.093 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.072722e-01 0.093 0 0
Intra-Golgi traffic R-HSA-6811438 8.072722e-01 0.093 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.072722e-01 0.093 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.081102e-01 0.093 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.081102e-01 0.093 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.081102e-01 0.093 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.081102e-01 0.093 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.081102e-01 0.093 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.082732e-01 0.092 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.104623e-01 0.091 0 0
Interleukin-21 signaling R-HSA-9020958 8.104623e-01 0.091 0 0
CASP8 activity is inhibited R-HSA-5218900 8.104623e-01 0.091 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.104623e-01 0.091 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.104623e-01 0.091 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.104623e-01 0.091 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.104623e-01 0.091 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.104623e-01 0.091 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 8.104623e-01 0.091 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 8.104623e-01 0.091 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 8.104623e-01 0.091 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 8.104623e-01 0.091 0 0
Inositol phosphate metabolism R-HSA-1483249 8.117262e-01 0.091 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.125022e-01 0.090 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.182712e-01 0.087 0 0
Mitophagy R-HSA-5205647 8.182712e-01 0.087 0 0
Nuclear import of Rev protein R-HSA-180746 8.182712e-01 0.087 0 0
Triglyceride metabolism R-HSA-8979227 8.183245e-01 0.087 0 0
Regulation of beta-cell development R-HSA-186712 8.183245e-01 0.087 1 0
Signaling by EGFR in Cancer R-HSA-1643713 8.190804e-01 0.087 0 0
Myogenesis R-HSA-525793 8.190804e-01 0.087 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.190804e-01 0.087 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.190804e-01 0.087 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.190804e-01 0.087 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.190804e-01 0.087 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.194942e-01 0.086 0 0
Regulated Necrosis R-HSA-5218859 8.243789e-01 0.084 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.247037e-01 0.084 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.272417e-01 0.082 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.272417e-01 0.082 0 0
Platelet sensitization by LDL R-HSA-432142 8.272417e-01 0.082 0 0
GABA receptor activation R-HSA-977443 8.295023e-01 0.081 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.322499e-01 0.080 0 0
HCMV Late Events R-HSA-9610379 8.335881e-01 0.079 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.346454e-01 0.078 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.346454e-01 0.078 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.350017e-01 0.078 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.350017e-01 0.078 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 8.350017e-01 0.078 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.350017e-01 0.078 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.350017e-01 0.078 0 0
Arachidonate production from DAG R-HSA-426048 8.350017e-01 0.078 0 0
Pexophagy R-HSA-9664873 8.350017e-01 0.078 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 8.350017e-01 0.078 0 0
Maturation of spike protein R-HSA-9683686 8.350017e-01 0.078 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.350017e-01 0.078 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.350017e-01 0.078 0 0
Sperm Motility And Taxes R-HSA-1300642 8.350017e-01 0.078 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.350017e-01 0.078 0 0
Peptide hormone biosynthesis R-HSA-209952 8.350017e-01 0.078 0 0
Orc1 removal from chromatin R-HSA-68949 8.362645e-01 0.078 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.362645e-01 0.078 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.362645e-01 0.078 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.446375e-01 0.073 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.446375e-01 0.073 0 0
Maturation of nucleoprotein R-HSA-9694631 8.446375e-01 0.073 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.446375e-01 0.073 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.452816e-01 0.073 0 0
DAP12 interactions R-HSA-2172127 8.452816e-01 0.073 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.453198e-01 0.073 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.453863e-01 0.073 0 0
Interferon gamma signaling R-HSA-877300 8.468551e-01 0.072 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.472029e-01 0.072 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.472029e-01 0.072 0 0
Clathrin-mediated endocytosis R-HSA-8856828 8.476351e-01 0.072 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.483046e-01 0.071 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.490422e-01 0.071 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.490422e-01 0.071 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.502220e-01 0.070 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.502220e-01 0.070 0 0
Signaling by PDGF R-HSA-186797 8.502220e-01 0.070 0 0
Toll-like Receptor Cascades R-HSA-168898 8.527902e-01 0.069 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 8.558942e-01 0.068 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.563653e-01 0.067 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.563653e-01 0.067 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.563653e-01 0.067 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.563653e-01 0.067 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.563653e-01 0.067 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.563653e-01 0.067 0 0
Biosynthesis of DPAn-3-derived maresins R-HSA-9026290 8.563653e-01 0.067 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.563653e-01 0.067 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.563653e-01 0.067 1 1
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.564893e-01 0.067 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.564893e-01 0.067 0 0
Degradation of AXIN R-HSA-4641257 8.575198e-01 0.067 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.575198e-01 0.067 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.586558e-01 0.066 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.597930e-01 0.066 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.604261e-01 0.065 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.604261e-01 0.065 0 0
Signal transduction by L1 R-HSA-445144 8.604261e-01 0.065 0 0
Nephrin family interactions R-HSA-373753 8.604261e-01 0.065 0 0
Ribosome-associated quality control R-HSA-9948299 8.615345e-01 0.065 0 0
mRNA Capping R-HSA-72086 8.623347e-01 0.064 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 8.659105e-01 0.063 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 8.661625e-01 0.062 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.670104e-01 0.062 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.670104e-01 0.062 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.688895e-01 0.061 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 8.688895e-01 0.061 0 0
GPCR downstream signalling R-HSA-388396 8.734431e-01 0.059 1 0
Leishmania phagocytosis R-HSA-9664417 8.738554e-01 0.059 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.738554e-01 0.059 0 0
Parasite infection R-HSA-9664407 8.738554e-01 0.059 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.745868e-01 0.058 0 0
Basigin interactions R-HSA-210991 8.747321e-01 0.058 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.747321e-01 0.058 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.749639e-01 0.058 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.749639e-01 0.058 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.749639e-01 0.058 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.749639e-01 0.058 0 0
Presynaptic nicotinic acetylcholine receptors R-HSA-622323 8.749639e-01 0.058 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.749639e-01 0.058 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.749639e-01 0.058 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.749639e-01 0.058 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 8.749639e-01 0.058 0 0
Influenza Infection R-HSA-168255 8.752705e-01 0.058 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.794693e-01 0.056 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.858620e-01 0.053 0 0
Cargo concentration in the ER R-HSA-5694530 8.858620e-01 0.053 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.858620e-01 0.053 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.858620e-01 0.053 0 0
Intraflagellar transport R-HSA-5620924 8.861063e-01 0.053 0 0
Metal ion SLC transporters R-HSA-425410 8.861063e-01 0.053 0 0
Signaling by FGFR R-HSA-190236 8.871980e-01 0.052 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 8.876746e-01 0.052 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.892998e-01 0.051 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.892998e-01 0.051 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.892998e-01 0.051 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 8.892998e-01 0.051 0 0
IRE1alpha activates chaperones R-HSA-381070 8.910182e-01 0.050 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.911552e-01 0.050 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.911552e-01 0.050 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.911552e-01 0.050 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.911552e-01 0.050 0 0
Biosynthesis of DPAn-3-derived protectins and resolvins R-HSA-9026286 8.911552e-01 0.050 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.911552e-01 0.050 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.911552e-01 0.050 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.911552e-01 0.050 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.911552e-01 0.050 0 0
OAS antiviral response R-HSA-8983711 8.911552e-01 0.050 0 0
Synthesis of DNA R-HSA-69239 8.962345e-01 0.048 0 0
Signaling by Insulin receptor R-HSA-74752 8.974235e-01 0.047 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.984212e-01 0.047 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.984212e-01 0.047 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.984212e-01 0.047 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.984212e-01 0.047 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 8.990146e-01 0.046 1 1
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.993599e-01 0.046 0 0
FGFR2 alternative splicing R-HSA-6803529 8.993668e-01 0.046 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.993668e-01 0.046 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 8.993668e-01 0.046 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 8.993668e-01 0.046 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.027993e-01 0.044 0 0
Interferon Signaling R-HSA-913531 9.028785e-01 0.044 0 0
Interferon alpha/beta signaling R-HSA-909733 9.044402e-01 0.044 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.052506e-01 0.043 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 9.052506e-01 0.043 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.052506e-01 0.043 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 9.052506e-01 0.043 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.052506e-01 0.043 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.052506e-01 0.043 0 0
Acetylcholine binding and downstream events R-HSA-181431 9.052506e-01 0.043 0 0
Chylomicron remodeling R-HSA-8963901 9.052506e-01 0.043 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.052506e-01 0.043 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 9.052506e-01 0.043 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.052506e-01 0.043 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.052506e-01 0.043 0 0
CD28 dependent Vav1 pathway R-HSA-389359 9.052506e-01 0.043 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.052506e-01 0.043 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 9.052506e-01 0.043 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.052506e-01 0.043 0 0
Immune System R-HSA-168256 9.059544e-01 0.043 1 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.068735e-01 0.042 0 0
HIV Transcription Initiation R-HSA-167161 9.068735e-01 0.042 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.068735e-01 0.042 0 0
HCMV Infection R-HSA-9609646 9.075428e-01 0.042 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.099153e-01 0.041 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.099153e-01 0.041 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.099153e-01 0.041 0 0
Carnitine shuttle R-HSA-200425 9.099153e-01 0.041 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.099153e-01 0.041 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.099153e-01 0.041 0 0
PPARA activates gene expression R-HSA-1989781 9.130620e-01 0.039 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.144395e-01 0.039 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.144395e-01 0.039 0 0
Activation of GABAB receptors R-HSA-991365 9.146955e-01 0.039 0 0
GABA B receptor activation R-HSA-977444 9.146955e-01 0.039 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.173193e-01 0.037 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.175214e-01 0.037 0 0
Prolactin receptor signaling R-HSA-1170546 9.175214e-01 0.037 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 9.175214e-01 0.037 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.175214e-01 0.037 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.175214e-01 0.037 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 9.175214e-01 0.037 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.175214e-01 0.037 0 0
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661 9.175214e-01 0.037 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.175214e-01 0.037 0 0
Malate-aspartate shuttle R-HSA-9856872 9.175214e-01 0.037 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.175214e-01 0.037 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.175214e-01 0.037 0 0
Ciprofloxacin ADME R-HSA-9793528 9.175214e-01 0.037 0 0
Signal regulatory protein family interactions R-HSA-391160 9.175214e-01 0.037 0 0
P2Y receptors R-HSA-417957 9.175214e-01 0.037 0 0
Zinc transporters R-HSA-435354 9.175214e-01 0.037 0 0
PKR-mediated signaling R-HSA-9833482 9.191260e-01 0.037 0 0
Signaling by MET R-HSA-6806834 9.191260e-01 0.037 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.210474e-01 0.036 0 0
Mitochondrial protein import R-HSA-1268020 9.210474e-01 0.036 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.213154e-01 0.036 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.219255e-01 0.035 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.224110e-01 0.035 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.224110e-01 0.035 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.224110e-01 0.035 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.238350e-01 0.034 0 0
COPI-mediated anterograde transport R-HSA-6807878 9.249245e-01 0.034 0 0
Potential therapeutics for SARS R-HSA-9679191 9.269237e-01 0.033 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.279751e-01 0.032 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.279751e-01 0.032 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.279751e-01 0.032 0 0
G protein gated Potassium channels R-HSA-1296059 9.279751e-01 0.032 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.279751e-01 0.032 0 0
Hyaluronan degradation R-HSA-2160916 9.279751e-01 0.032 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.282036e-01 0.032 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.282036e-01 0.032 0 0
Protein lipoylation R-HSA-9857492 9.282036e-01 0.032 0 0
Signaling by Activin R-HSA-1502540 9.282036e-01 0.032 0 0
Biotin transport and metabolism R-HSA-196780 9.282036e-01 0.032 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.282036e-01 0.032 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 9.282036e-01 0.032 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 9.282036e-01 0.032 0 0
DNA Damage Reversal R-HSA-73942 9.282036e-01 0.032 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.288515e-01 0.032 0 0
Downstream TCR signaling R-HSA-202424 9.293622e-01 0.032 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.296970e-01 0.032 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.298909e-01 0.032 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.344142e-01 0.029 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.347554e-01 0.029 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.347554e-01 0.029 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 9.347554e-01 0.029 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.356663e-01 0.029 0 0
Abacavir ADME R-HSA-2161522 9.356663e-01 0.029 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.363486e-01 0.029 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.375029e-01 0.028 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.375029e-01 0.028 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.375029e-01 0.028 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.375029e-01 0.028 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 9.375029e-01 0.028 0 0
Activation of SMO R-HSA-5635838 9.375029e-01 0.028 0 0
Fructose catabolism R-HSA-70350 9.375029e-01 0.028 0 0
Negative regulation of FLT3 R-HSA-9706369 9.375029e-01 0.028 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.375029e-01 0.028 0 0
Atorvastatin ADME R-HSA-9754706 9.375029e-01 0.028 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.376653e-01 0.028 1 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.385847e-01 0.028 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.401685e-01 0.027 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.404251e-01 0.027 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.404251e-01 0.027 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.407284e-01 0.027 0 0
Degradation of DVL R-HSA-4641258 9.424144e-01 0.026 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.424144e-01 0.026 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.424144e-01 0.026 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.425740e-01 0.026 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.425740e-01 0.026 0 0
Signaling by BMP R-HSA-201451 9.425740e-01 0.026 0 0
Insulin processing R-HSA-264876 9.425740e-01 0.026 0 0
Phospholipid metabolism R-HSA-1483257 9.441062e-01 0.025 0 0
UCH proteinases R-HSA-5689603 9.445184e-01 0.025 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.455981e-01 0.024 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.455981e-01 0.024 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.455981e-01 0.024 0 0
Glycine degradation R-HSA-6783984 9.455981e-01 0.024 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 9.455981e-01 0.024 0 0
Coenzyme A biosynthesis R-HSA-196783 9.455981e-01 0.024 0 0
Response to metal ions R-HSA-5660526 9.455981e-01 0.024 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.455981e-01 0.024 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.456423e-01 0.024 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.471130e-01 0.024 0 0
Circadian clock R-HSA-9909396 9.471825e-01 0.024 0 0
G alpha (q) signalling events R-HSA-416476 9.483848e-01 0.023 0 0
Translation of Structural Proteins R-HSA-9694635 9.485848e-01 0.023 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.487721e-01 0.023 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 9.508521e-01 0.022 0 0
rRNA processing R-HSA-72312 9.512487e-01 0.022 0 0
PCP/CE pathway R-HSA-4086400 9.523830e-01 0.021 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.526452e-01 0.021 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.526452e-01 0.021 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.526452e-01 0.021 0 0
Glycogen storage diseases R-HSA-3229121 9.526452e-01 0.021 0 0
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265 9.526452e-01 0.021 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.526452e-01 0.021 0 0
Sulfide oxidation to sulfate R-HSA-1614517 9.526452e-01 0.021 0 0
GDP-fucose biosynthesis R-HSA-6787639 9.526452e-01 0.021 0 0
Choline catabolism R-HSA-6798163 9.526452e-01 0.021 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.526873e-01 0.021 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.529683e-01 0.021 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.543286e-01 0.020 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.543286e-01 0.020 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.543286e-01 0.020 0 0
Late Phase of HIV Life Cycle R-HSA-162599 9.562973e-01 0.019 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.579909e-01 0.019 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.587798e-01 0.018 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.587798e-01 0.018 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.587798e-01 0.018 0 0
Biosynthesis of Lipoxins (LX) R-HSA-2142700 9.587798e-01 0.018 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.587798e-01 0.018 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.587798e-01 0.018 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.587798e-01 0.018 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.587798e-01 0.018 0 0
Nephron development R-HSA-9831926 9.587798e-01 0.018 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.587798e-01 0.018 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.593055e-01 0.018 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.615188e-01 0.017 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.615188e-01 0.017 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.615677e-01 0.017 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.616919e-01 0.017 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.625864e-01 0.017 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.625864e-01 0.017 0 0
The phototransduction cascade R-HSA-2514856 9.625864e-01 0.017 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.637599e-01 0.016 0 0
Budding and maturation of HIV virion R-HSA-162588 9.637599e-01 0.016 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.637599e-01 0.016 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.637599e-01 0.016 0 0
Translesion Synthesis by POLH R-HSA-110320 9.641200e-01 0.016 0 0
Pyrimidine biosynthesis R-HSA-500753 9.641200e-01 0.016 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 9.641200e-01 0.016 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.641200e-01 0.016 0 0
Regulation of signaling by CBL R-HSA-912631 9.641200e-01 0.016 0 0
Diseases of hemostasis R-HSA-9671793 9.641200e-01 0.016 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.641200e-01 0.016 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 9.646363e-01 0.016 0 0
Translation of Structural Proteins R-HSA-9683701 9.654599e-01 0.015 0 0
Selenoamino acid metabolism R-HSA-2408522 9.661967e-01 0.015 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.677434e-01 0.014 0 0
Host Interactions of HIV factors R-HSA-162909 9.677697e-01 0.014 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.678477e-01 0.014 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.681656e-01 0.014 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.687686e-01 0.014 0 0
Glycogen synthesis R-HSA-3322077 9.687686e-01 0.014 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.687686e-01 0.014 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.687686e-01 0.014 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.687686e-01 0.014 0 0
Pregnenolone biosynthesis R-HSA-196108 9.687686e-01 0.014 0 0
Negative regulation of MET activity R-HSA-6807004 9.687686e-01 0.014 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.687686e-01 0.014 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.688762e-01 0.014 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.688762e-01 0.014 0 0
Neutrophil degranulation R-HSA-6798695 9.705847e-01 0.013 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.713034e-01 0.013 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.713034e-01 0.013 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.719712e-01 0.012 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.728152e-01 0.012 0 0
G-protein activation R-HSA-202040 9.728152e-01 0.012 0 0
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896 9.728152e-01 0.012 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.728152e-01 0.012 0 0
Phenylalanine metabolism R-HSA-8964208 9.728152e-01 0.012 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.728152e-01 0.012 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.728152e-01 0.012 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.744826e-01 0.011 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.744826e-01 0.011 0 0
Heme degradation R-HSA-189483 9.744826e-01 0.011 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.745117e-01 0.011 0 0
Surfactant metabolism R-HSA-5683826 9.747729e-01 0.011 0 0
Attachment and Entry R-HSA-9694614 9.763377e-01 0.010 0 0
Assembly Of The HIV Virion R-HSA-175474 9.763377e-01 0.010 0 0
Serine metabolism R-HSA-977347 9.763377e-01 0.010 0 0
Glutathione synthesis and recycling R-HSA-174403 9.763377e-01 0.010 0 0
Somitogenesis R-HSA-9824272 9.773071e-01 0.010 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.773200e-01 0.010 0 0
eNOS activation R-HSA-203615 9.773200e-01 0.010 0 0
Signal amplification R-HSA-392518 9.773200e-01 0.010 0 0
Hyaluronan metabolism R-HSA-2142845 9.773200e-01 0.010 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.775545e-01 0.010 0 0
Signaling by GPCR R-HSA-372790 9.780667e-01 0.010 1 0
ABC transporter disorders R-HSA-5619084 9.787945e-01 0.009 0 0
Interleukin-10 signaling R-HSA-6783783 9.787945e-01 0.009 0 0
Integrin cell surface interactions R-HSA-216083 9.787945e-01 0.009 0 0
SARS-CoV Infections R-HSA-9679506 9.788100e-01 0.009 1 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.794039e-01 0.009 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 9.794039e-01 0.009 0 0
Biosynthesis of D-series resolvins R-HSA-9018676 9.794039e-01 0.009 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.794039e-01 0.009 0 0
Fructose metabolism R-HSA-5652084 9.794039e-01 0.009 0 0
Ethanol oxidation R-HSA-71384 9.794039e-01 0.009 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.794039e-01 0.009 0 0
Cellular hexose transport R-HSA-189200 9.794039e-01 0.009 0 0
LDL clearance R-HSA-8964038 9.794039e-01 0.009 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.794039e-01 0.009 0 0
PERK regulates gene expression R-HSA-381042 9.798507e-01 0.009 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.798507e-01 0.009 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.798507e-01 0.009 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.798507e-01 0.009 0 0
Regulation of Apoptosis R-HSA-169911 9.798507e-01 0.009 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.805645e-01 0.009 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.810034e-01 0.008 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.818173e-01 0.008 0 0
Hemostasis R-HSA-109582 9.818735e-01 0.008 0 0
ER-Phagosome pathway R-HSA-1236974 9.818743e-01 0.008 0 0
Vesicle-mediated transport R-HSA-5653656 9.819704e-01 0.008 1 0
Termination of O-glycan biosynthesis R-HSA-977068 9.820730e-01 0.008 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.820730e-01 0.008 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.820730e-01 0.008 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.820730e-01 0.008 0 0
Biosynthesis of maresins R-HSA-9018682 9.820730e-01 0.008 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.820730e-01 0.008 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.821066e-01 0.008 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.821066e-01 0.008 0 0
HIV Life Cycle R-HSA-162587 9.827554e-01 0.008 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.827952e-01 0.008 0 0
COPII-mediated vesicle transport R-HSA-204005 9.829880e-01 0.007 0 0
Neurotransmitter release cycle R-HSA-112310 9.833338e-01 0.007 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.841164e-01 0.007 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.841164e-01 0.007 0 0
NCAM1 interactions R-HSA-419037 9.841164e-01 0.007 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.843963e-01 0.007 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.843963e-01 0.007 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.843963e-01 0.007 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.843963e-01 0.007 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.843963e-01 0.007 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.843963e-01 0.007 0 0
Complex III assembly R-HSA-9865881 9.843963e-01 0.007 0 0
RAB geranylgeranylation R-HSA-8873719 9.844261e-01 0.007 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.847188e-01 0.007 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.852186e-01 0.006 0 0
Gap junction trafficking and regulation R-HSA-157858 9.852186e-01 0.006 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.859059e-01 0.006 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.864186e-01 0.006 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.864186e-01 0.006 0 0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives R-HSA-9027604 9.864186e-01 0.006 0 0
Laminin interactions R-HSA-3000157 9.864186e-01 0.006 0 0
Fertilization R-HSA-1187000 9.864186e-01 0.006 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.870819e-01 0.006 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.870819e-01 0.006 0 0
tRNA processing in the nucleus R-HSA-6784531 9.872580e-01 0.006 0 0
Pentose phosphate pathway R-HSA-71336 9.874985e-01 0.005 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.874985e-01 0.005 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.874985e-01 0.005 0 0
MET activates PTK2 signaling R-HSA-8874081 9.881789e-01 0.005 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.881789e-01 0.005 0 0
Urea cycle R-HSA-70635 9.881789e-01 0.005 0 0
Sphingolipid catabolism R-HSA-9845614 9.881789e-01 0.005 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.889152e-01 0.005 0 0
Mitochondrial protein degradation R-HSA-9837999 9.891252e-01 0.005 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.897112e-01 0.004 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.897112e-01 0.004 0 0
Biosynthesis of DPAn-3 SPMs R-HSA-9025094 9.897112e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.897112e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.897112e-01 0.004 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.897112e-01 0.004 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.897871e-01 0.004 0 0
HIV Infection R-HSA-162906 9.898657e-01 0.004 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.901747e-01 0.004 0 0
RSV-host interactions R-HSA-9833110 9.906064e-01 0.004 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.908810e-01 0.004 0 0
Prednisone ADME R-HSA-9757110 9.910449e-01 0.004 0 0
Insulin receptor recycling R-HSA-77387 9.910449e-01 0.004 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.910449e-01 0.004 0 0
Pyrimidine salvage R-HSA-73614 9.910449e-01 0.004 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.912941e-01 0.004 0 0
Heme biosynthesis R-HSA-189451 9.912941e-01 0.004 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.913265e-01 0.004 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.915192e-01 0.004 0 0
Formation of the cornified envelope R-HSA-6809371 9.919222e-01 0.004 0 0
Thyroxine biosynthesis R-HSA-209968 9.922058e-01 0.003 0 0
Biosynthesis of EPA-derived SPMs R-HSA-9018679 9.922058e-01 0.003 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.922058e-01 0.003 0 0
Glucagon-type ligand receptors R-HSA-420092 9.922058e-01 0.003 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.922884e-01 0.003 0 0
G alpha (z) signalling events R-HSA-418597 9.923376e-01 0.003 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.925881e-01 0.003 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.931713e-01 0.003 0 0
Defensins R-HSA-1461973 9.931713e-01 0.003 0 0
Neurotransmitter clearance R-HSA-112311 9.932163e-01 0.003 0 0
Peptide hormone metabolism R-HSA-2980736 9.936982e-01 0.003 0 0
Protein localization R-HSA-9609507 9.938438e-01 0.003 0 0
Proteasome assembly R-HSA-9907900 9.939550e-01 0.003 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.939550e-01 0.003 0 0
Gap junction trafficking R-HSA-190828 9.939550e-01 0.003 0 0
Biosynthesis of DPA-derived SPMs R-HSA-9018683 9.940958e-01 0.003 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.940958e-01 0.003 0 0
Platelet degranulation R-HSA-114608 9.941273e-01 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.943950e-01 0.002 0 0
HS-GAG degradation R-HSA-2024096 9.948613e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.949515e-01 0.002 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.949795e-01 0.002 0 0
Protein folding R-HSA-391251 9.950369e-01 0.002 0 0
Peroxisomal protein import R-HSA-9033241 9.950958e-01 0.002 0 0
Neddylation R-HSA-8951664 9.952601e-01 0.002 0 0
Recycling of bile acids and salts R-HSA-159418 9.955276e-01 0.002 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.955276e-01 0.002 0 0
tRNA Aminoacylation R-HSA-379724 9.956175e-01 0.002 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.956175e-01 0.002 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.961076e-01 0.002 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.963195e-01 0.002 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.966123e-01 0.001 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.966123e-01 0.001 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.966123e-01 0.001 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.966123e-01 0.001 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.966899e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.970517e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.970517e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.973396e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.973396e-01 0.001 0 0
HS-GAG biosynthesis R-HSA-2022928 9.974341e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.974446e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.975974e-01 0.001 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 9.977669e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.977669e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.977669e-01 0.001 0 0
Collagen chain trimerization R-HSA-8948216 9.977669e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.977669e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.979082e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.980063e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.980245e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.980245e-01 0.001 0 0
Purine salvage R-HSA-74217 9.980565e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.980565e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.982393e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.983086e-01 0.001 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.983086e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.985280e-01 0.001 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.985280e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.985370e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.986285e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.986994e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.987190e-01 0.001 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.987555e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.987555e-01 0.001 0 0
Metabolism of porphyrins R-HSA-189445 9.987555e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.987897e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.987897e-01 0.001 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.988920e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.989051e-01 0.000 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.990582e-01 0.000 0 0
SLC transporter disorders R-HSA-5619102 9.990725e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.990974e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.991694e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.992193e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.992193e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.992653e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.992677e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.992677e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.993606e-01 0.000 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.993606e-01 0.000 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.994436e-01 0.000 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.995158e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.995158e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.995787e-01 0.000 0 0
Gluconeogenesis R-HSA-70263 9.995787e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.996334e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.996334e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.996571e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.996573e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.996980e-01 0.000 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.997375e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.997639e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.997639e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.997790e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.997908e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.997939e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998118e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998186e-01 0.000 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.998213e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998404e-01 0.000 0 0
Paracetamol ADME R-HSA-9753281 9.998408e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.998458e-01 0.000 0 0
Digestion R-HSA-8935690 9.998615e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.998699e-01 0.000 1 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998937e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999036e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999088e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999155e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999159e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999206e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999309e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999428e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999477e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999526e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.999545e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999604e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999625e-01 0.000 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.999654e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999694e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999709e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.999765e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999769e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999797e-01 0.000 0 0
tRNA processing R-HSA-72306 9.999912e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999928e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999928e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999930e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999944e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999957e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999972e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999975e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999978e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999982e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999983e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999989e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999991e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999992e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999992e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999994e-01 0.000 0 0
Translation R-HSA-72766 9.999997e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999998e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999998e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999999e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 1 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 1 0
Asparagine N-linked glycosylation R-HSA-446203 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 9.514703e-10 9.022 1 1
Cell Cycle, Mitotic R-HSA-69278 1.036302e-08 7.985 1 0
Cell Cycle R-HSA-1640170 1.837240e-08 7.736 1 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.639404e-08 7.578 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.358393e-08 7.029 0 0
Cell Cycle Checkpoints R-HSA-69620 1.364631e-07 6.865 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.689243e-07 6.570 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.823368e-07 6.549 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.543348e-07 6.451 0 0
mRNA Splicing R-HSA-72172 3.880087e-07 6.411 0 0
DNA Double Strand Break Response R-HSA-5693606 5.123013e-07 6.290 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.306622e-07 6.200 1 1
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.721452e-07 6.242 0 0
M Phase R-HSA-68886 5.845001e-07 6.233 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.038403e-07 6.219 1 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.216369e-06 5.915 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.216369e-06 5.915 0 0
Meiotic synapsis R-HSA-1221632 3.090134e-06 5.510 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 3.342168e-06 5.476 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.548148e-06 5.450 0 0
Mitotic Prophase R-HSA-68875 3.894104e-06 5.410 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.232728e-06 5.373 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.632916e-06 5.334 1 1
p75 NTR receptor-mediated signalling R-HSA-193704 4.860476e-06 5.313 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.081050e-06 5.216 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 8.167701e-06 5.088 0 0
Signal Transduction R-HSA-162582 8.229036e-06 5.085 1 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.896499e-06 5.103 0 0
mRNA 3'-end processing R-HSA-72187 8.710340e-06 5.060 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.950979e-06 5.048 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.548292e-06 5.020 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.011852e-05 4.995 0 0
Cell junction organization R-HSA-446728 9.939729e-06 5.003 0 0
Chromatin organization R-HSA-4839726 1.093322e-05 4.961 0 0
G2/M Checkpoints R-HSA-69481 1.215544e-05 4.915 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.550015e-05 4.810 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.474859e-05 4.831 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.523213e-05 4.817 0 0
Cellular Senescence R-HSA-2559583 1.486556e-05 4.828 0 0
Cell-Cell communication R-HSA-1500931 1.874830e-05 4.727 0 0
Adherens junctions interactions R-HSA-418990 1.973917e-05 4.705 0 0
Chromatin modifying enzymes R-HSA-3247509 2.206936e-05 4.656 0 0
FLT3 Signaling R-HSA-9607240 2.371626e-05 4.625 1 1
Packaging Of Telomere Ends R-HSA-171306 2.543331e-05 4.595 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.603189e-05 4.584 0 0
Apoptotic execution phase R-HSA-75153 2.720031e-05 4.565 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.975694e-05 4.526 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 3.139983e-05 4.503 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.275768e-05 4.485 0 0
Metabolism of RNA R-HSA-8953854 3.725163e-05 4.429 0 0
Death Receptor Signaling R-HSA-73887 3.876409e-05 4.412 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.285818e-05 4.368 0 0
Homology Directed Repair R-HSA-5693538 4.723329e-05 4.326 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.611989e-05 4.251 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.815541e-05 4.235 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.486283e-05 4.188 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.787153e-05 4.168 0 0
NRAGE signals death through JNK R-HSA-193648 6.693767e-05 4.174 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.527944e-05 4.021 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.249809e-05 4.034 0 0
Regulation of TP53 Degradation R-HSA-6804757 9.527944e-05 4.021 1 1
TCF dependent signaling in response to WNT R-HSA-201681 9.298444e-05 4.032 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.411569e-05 4.026 0 0
Chaperone Mediated Autophagy R-HSA-9613829 9.639657e-05 4.016 0 0
Cell-cell junction organization R-HSA-421270 1.001337e-04 3.999 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.079732e-04 3.967 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.101664e-04 3.958 0 0
ESR-mediated signaling R-HSA-8939211 1.129774e-04 3.947 1 0
Cleavage of the damaged purine R-HSA-110331 1.205654e-04 3.919 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.258202e-04 3.900 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.330202e-04 3.876 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.404089e-04 3.853 0 0
Depurination R-HSA-73927 1.514699e-04 3.820 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.641838e-04 3.785 0 0
DNA methylation R-HSA-5334118 1.843400e-04 3.734 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.872683e-04 3.728 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.889944e-04 3.724 1 0
Protein ubiquitination R-HSA-8852135 2.100733e-04 3.678 0 0
S Phase R-HSA-69242 2.102301e-04 3.677 1 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.263448e-04 3.645 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.373017e-04 3.625 1 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 2.444981e-04 3.612 0 0
Nucleosome assembly R-HSA-774815 2.444981e-04 3.612 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.592431e-04 3.586 1 0
Mitotic Anaphase R-HSA-68882 2.596714e-04 3.586 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.767573e-04 3.558 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.823155e-04 3.549 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 3.012905e-04 3.521 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 3.026822e-04 3.519 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.925575e-04 3.534 0 0
Signaling by ALK in cancer R-HSA-9700206 2.925575e-04 3.534 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.537355e-04 3.451 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.478215e-04 3.459 0 0
Meiosis R-HSA-1500620 3.460946e-04 3.461 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 4.301268e-04 3.366 0 0
Depyrimidination R-HSA-73928 4.301268e-04 3.366 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.665538e-04 3.331 1 1
Deubiquitination R-HSA-5688426 4.709205e-04 3.327 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.799726e-04 3.319 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.068361e-04 3.295 1 0
Amyloid fiber formation R-HSA-977225 5.010876e-04 3.300 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.167050e-04 3.287 0 0
HATs acetylate histones R-HSA-3214847 5.320995e-04 3.274 0 0
Reproduction R-HSA-1474165 5.452801e-04 3.263 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.545258e-04 3.256 0 0
p75NTR signals via NF-kB R-HSA-193639 5.779581e-04 3.238 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.319953e-04 3.199 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.236575e-04 3.205 0 0
Gene Silencing by RNA R-HSA-211000 6.686998e-04 3.175 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.799515e-04 3.168 1 0
DNA Replication R-HSA-69306 7.087128e-04 3.150 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 7.571566e-04 3.121 0 0
Negative regulation of FLT3 R-HSA-9706369 8.022762e-04 3.096 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.138933e-04 3.039 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.083967e-04 3.042 1 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.138933e-04 3.039 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.052211e-03 2.978 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.096633e-03 2.960 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.172248e-03 2.931 1 1
Base-Excision Repair, AP Site Formation R-HSA-73929 1.181127e-03 2.928 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.333732e-03 2.875 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.372156e-03 2.863 0 0
Diseases of programmed cell death R-HSA-9645723 1.391404e-03 2.857 0 0
Defective pyroptosis R-HSA-9710421 1.555508e-03 2.808 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.605239e-03 2.794 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.605239e-03 2.794 0 0
Cellular response to heat stress R-HSA-3371556 1.667320e-03 2.778 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.750040e-03 2.757 0 0
Josephin domain DUBs R-HSA-5689877 1.750040e-03 2.757 0 0
Regulation of CDH1 Function R-HSA-9764561 1.853329e-03 2.732 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.750040e-03 2.757 0 0
Separation of Sister Chromatids R-HSA-2467813 1.841980e-03 2.735 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.853329e-03 2.732 0 0
Pexophagy R-HSA-9664873 1.750040e-03 2.757 0 0
Base Excision Repair R-HSA-73884 1.757342e-03 2.755 0 0
Cellular responses to stimuli R-HSA-8953897 1.926646e-03 2.715 1 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.949307e-03 2.710 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.968991e-03 2.706 0 0
G alpha (12/13) signalling events R-HSA-416482 2.002484e-03 2.698 0 0
Meiotic recombination R-HSA-912446 2.014826e-03 2.696 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.147370e-03 2.668 1 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.215687e-03 2.654 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.483905e-03 2.605 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.483905e-03 2.605 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 2.340196e-03 2.631 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.281873e-03 2.642 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.351088e-03 2.629 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.281873e-03 2.642 0 0
Regulation of TP53 Activity R-HSA-5633007 2.510401e-03 2.600 1 0
DCC mediated attractive signaling R-HSA-418885 2.637908e-03 2.579 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.637908e-03 2.579 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.637908e-03 2.579 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.637908e-03 2.579 0 0
Signaling by VEGF R-HSA-194138 2.664789e-03 2.574 1 0
Co-inhibition by PD-1 R-HSA-389948 2.733148e-03 2.563 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.762051e-03 2.559 0 0
Signaling by ERBB2 R-HSA-1227986 2.817935e-03 2.550 1 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.823810e-03 2.549 1 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.826328e-03 2.549 1 1
Regulation of PTEN localization R-HSA-8948747 2.979503e-03 2.526 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.172729e-03 2.499 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.936055e-03 2.532 0 0
Negative regulation of MET activity R-HSA-6807004 3.172729e-03 2.499 0 0
Apoptosis R-HSA-109581 2.940394e-03 2.532 1 0
Signaling by RAF1 mutants R-HSA-9656223 3.176500e-03 2.498 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.251953e-03 2.488 0 0
NF-kB is activated and signals survival R-HSA-209560 3.524208e-03 2.453 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.587715e-03 2.445 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.684525e-03 2.434 1 1
MTOR signalling R-HSA-165159 3.719837e-03 2.429 0 0
Ub-specific processing proteases R-HSA-5689880 3.985217e-03 2.400 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.001475e-03 2.398 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.007546e-03 2.397 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.033406e-03 2.394 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.442125e-03 2.352 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.442125e-03 2.352 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 4.442125e-03 2.352 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.677596e-03 2.330 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.677596e-03 2.330 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.464892e-03 2.350 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.442125e-03 2.352 0 0
Signaling by PTK6 R-HSA-8848021 4.163314e-03 2.381 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 4.163314e-03 2.381 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 4.796302e-03 2.319 0 0
IRAK1 recruits IKK complex R-HSA-937039 4.796302e-03 2.319 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.987892e-03 2.302 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.249512e-03 2.280 0 0
Membrane Trafficking R-HSA-199991 5.409605e-03 2.267 1 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.508651e-03 2.259 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.865742e-03 2.232 0 0
Striated Muscle Contraction R-HSA-390522 5.865742e-03 2.232 0 0
Dual Incision in GG-NER R-HSA-5696400 6.910375e-03 2.160 0 0
Signaling downstream of RAS mutants R-HSA-9649948 6.684903e-03 2.175 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.684903e-03 2.175 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.684903e-03 2.175 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.354887e-03 2.197 0 0
Signaling by RAS mutants R-HSA-6802949 6.684903e-03 2.175 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 6.354887e-03 2.197 0 0
Signaling by WNT R-HSA-195721 6.903017e-03 2.161 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.910375e-03 2.160 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.950618e-03 2.158 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.950618e-03 2.158 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.950618e-03 2.158 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.950618e-03 2.158 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.950618e-03 2.158 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.950618e-03 2.158 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.950618e-03 2.158 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.950618e-03 2.158 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.950618e-03 2.158 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.950618e-03 2.158 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.950618e-03 2.158 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 7.313822e-03 2.136 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.322966e-03 2.135 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 7.401158e-03 2.131 1 1
PKMTs methylate histone lysines R-HSA-3214841 7.401158e-03 2.131 0 0
Maturation of protein E R-HSA-9683683 7.699129e-03 2.114 0 0
Maturation of protein E R-HSA-9694493 7.699129e-03 2.114 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.093548e-03 2.092 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 8.305995e-03 2.081 0 0
HDACs deacetylate histones R-HSA-3214815 8.756018e-03 2.058 0 0
Mitotic Prometaphase R-HSA-68877 8.856634e-03 2.053 0 0
Cellular responses to stress R-HSA-2262752 8.894164e-03 2.051 1 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.875054e-03 2.005 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.046310e-02 1.980 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.046310e-02 1.980 0 0
Oncogenic MAPK signaling R-HSA-6802957 9.505488e-03 2.022 0 0
DNA Damage Bypass R-HSA-73893 9.939079e-03 2.003 0 0
Signaling by EGFR R-HSA-177929 9.875054e-03 2.005 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 9.723731e-03 2.012 1 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.062131e-02 1.974 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.062131e-02 1.974 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.062131e-02 1.974 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.062131e-02 1.974 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.088287e-02 1.963 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.088287e-02 1.963 0 0
TGFBR3 expression R-HSA-9839394 1.088287e-02 1.963 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.112634e-02 1.954 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.156451e-02 1.937 1 1
Programmed Cell Death R-HSA-5357801 1.169622e-02 1.932 1 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.178334e-02 1.929 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.178334e-02 1.929 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.215670e-02 1.915 0 0
Signaling by MET R-HSA-6806834 1.215670e-02 1.915 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.244546e-02 1.905 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.266035e-02 1.898 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.279685e-02 1.893 0 0
Metalloprotease DUBs R-HSA-5689901 1.293902e-02 1.888 0 0
Axon guidance R-HSA-422475 1.343652e-02 1.872 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.351897e-02 1.869 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.351897e-02 1.869 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.621867e-02 1.790 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.541487e-02 1.812 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.625929e-02 1.789 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.625929e-02 1.789 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.625929e-02 1.789 0 0
Metabolism of non-coding RNA R-HSA-194441 1.391017e-02 1.857 0 0
snRNP Assembly R-HSA-191859 1.391017e-02 1.857 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.625929e-02 1.789 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.541487e-02 1.812 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.655796e-02 1.781 0 0
Nuclear RNA decay R-HSA-9930044 1.397253e-02 1.855 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 1.526592e-02 1.816 1 1
Listeria monocytogenes entry into host cells R-HSA-8876384 1.625929e-02 1.789 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.541487e-02 1.812 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.526592e-02 1.816 0 0
DNA Repair R-HSA-73894 1.610672e-02 1.793 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.444101e-02 1.840 0 0
Rab regulation of trafficking R-HSA-9007101 1.673971e-02 1.776 1 0
G1/S Transition R-HSA-69206 1.783086e-02 1.749 1 0
Translation initiation complex formation R-HSA-72649 1.793658e-02 1.746 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.861502e-02 1.730 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.874527e-02 1.727 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.910304e-02 1.719 0 0
Nucleotide Excision Repair R-HSA-5696398 1.961779e-02 1.707 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.972583e-02 1.705 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.972583e-02 1.705 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.995987e-02 1.700 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.995987e-02 1.700 1 1
Signaling by Hippo R-HSA-2028269 2.024717e-02 1.694 0 0
Specification of primordial germ cells R-HSA-9827857 2.024717e-02 1.694 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.040984e-02 1.690 0 0
RNA Polymerase I Transcription R-HSA-73864 2.055869e-02 1.687 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.080429e-02 1.682 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.116265e-02 1.674 0 0
Oncogene Induced Senescence R-HSA-2559585 2.131517e-02 1.671 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.153258e-02 1.667 1 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.206649e-02 1.656 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.206649e-02 1.656 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.206649e-02 1.656 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.221987e-02 1.653 0 0
TNF signaling R-HSA-75893 2.221987e-02 1.653 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.228397e-02 1.652 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.245778e-02 1.649 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.250849e-02 1.648 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.405014e-02 1.619 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.421102e-02 1.616 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.024754e-02 1.519 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.905080e-02 1.537 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.054902e-02 1.515 0 0
Regulation of signaling by CBL R-HSA-912631 2.921571e-02 1.534 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.921571e-02 1.534 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.763515e-02 1.559 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.763515e-02 1.559 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.753936e-02 1.560 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.584692e-02 1.588 0 0
EGFR downregulation R-HSA-182971 2.763515e-02 1.559 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.863581e-02 1.543 1 0
Translesion Synthesis by POLH R-HSA-110320 2.921571e-02 1.534 0 0
HSF1-dependent transactivation R-HSA-3371571 2.872183e-02 1.542 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.753936e-02 1.560 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.921571e-02 1.534 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.636066e-02 1.579 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 3.054902e-02 1.515 0 0
MAPK family signaling cascades R-HSA-5683057 2.856494e-02 1.544 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.054902e-02 1.515 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.624363e-02 1.581 1 0
Nervous system development R-HSA-9675108 2.483779e-02 1.605 0 0
Signaling by ROBO receptors R-HSA-376176 2.551214e-02 1.593 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.828259e-02 1.548 1 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.475881e-02 1.606 1 1
Long-term potentiation R-HSA-9620244 3.115159e-02 1.507 0 0
G0 and Early G1 R-HSA-1538133 3.157400e-02 1.501 0 0
Orc1 removal from chromatin R-HSA-68949 3.181909e-02 1.497 0 0
Neurexins and neuroligins R-HSA-6794361 3.181909e-02 1.497 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.264375e-02 1.486 0 0
Kinesins R-HSA-983189 3.298008e-02 1.482 0 0
Telomere Maintenance R-HSA-157579 3.353462e-02 1.475 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.385587e-02 1.470 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.400696e-02 1.468 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.405480e-02 1.468 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 3.454418e-02 1.462 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.494258e-02 1.457 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.514645e-02 1.454 1 1
IPs transport between nucleus and cytosol R-HSA-1855170 3.588010e-02 1.445 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.595629e-02 1.444 0 0
Myogenesis R-HSA-525793 3.595629e-02 1.444 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.620630e-02 1.441 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.709100e-02 1.431 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.712388e-02 1.430 1 1
Translesion synthesis by REV1 R-HSA-110312 3.712388e-02 1.430 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.720504e-02 1.429 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.723489e-02 1.429 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.723489e-02 1.429 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.723489e-02 1.429 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.723489e-02 1.429 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 3.829026e-02 1.417 1 1
Chromosome Maintenance R-HSA-73886 3.855255e-02 1.414 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.911354e-02 1.408 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.956852e-02 1.403 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 4.046189e-02 1.393 0 0
Synthesis of DNA R-HSA-69239 4.053847e-02 1.392 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.056550e-02 1.392 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.122614e-02 1.385 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.123221e-02 1.385 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 5.658823e-02 1.247 0 0
Translesion synthesis by POLI R-HSA-5656121 4.450293e-02 1.352 0 0
Translesion synthesis by POLK R-HSA-5655862 5.269780e-02 1.278 0 0
FGFR2 alternative splicing R-HSA-6803529 5.411999e-02 1.267 0 0
RAF activation R-HSA-5673000 4.564075e-02 1.341 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.361168e-02 1.271 0 0
Dual incision in TC-NER R-HSA-6782135 5.547330e-02 1.256 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.701835e-02 1.328 0 0
mTORC1-mediated signalling R-HSA-166208 5.411999e-02 1.267 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.361007e-02 1.360 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.699519e-02 1.244 0 0
HSF1 activation R-HSA-3371511 5.699519e-02 1.244 0 0
Negative regulation of MAPK pathway R-HSA-5675221 4.844041e-02 1.315 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.450293e-02 1.352 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.111486e-02 1.291 0 0
HIV Life Cycle R-HSA-162587 5.270140e-02 1.278 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 5.269780e-02 1.278 0 0
Autophagy R-HSA-9612973 5.006362e-02 1.300 0 0
Co-stimulation by CD28 R-HSA-389356 4.551338e-02 1.342 1 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.269780e-02 1.278 0 0
FLT3 signaling in disease R-HSA-9682385 5.699519e-02 1.244 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.702862e-02 1.328 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.361168e-02 1.271 0 0
Nuclear import of Rev protein R-HSA-180746 4.564075e-02 1.341 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.507631e-02 1.346 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 4.698362e-02 1.328 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.916367e-02 1.228 0 0
Activation of the pre-replicative complex R-HSA-68962 5.993682e-02 1.222 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.006757e-02 1.221 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.076749e-02 1.216 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.171242e-02 1.210 0 0
Glycogen storage diseases R-HSA-3229121 6.171242e-02 1.210 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 6.187743e-02 1.208 1 1
Muscle contraction R-HSA-397014 6.198065e-02 1.208 0 0
G2/M Transition R-HSA-69275 6.199943e-02 1.208 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.328742e-02 1.199 0 0
Degradation of DVL R-HSA-4641258 6.328742e-02 1.199 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.559934e-02 1.183 0 0
Trafficking of AMPA receptors R-HSA-399719 6.716494e-02 1.173 0 0
Mitotic G2-G2/M phases R-HSA-453274 6.778548e-02 1.169 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.874837e-02 1.163 0 0
Eukaryotic Translation Elongation R-HSA-156842 6.919968e-02 1.160 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 6.999551e-02 1.155 0 0
Neurodegenerative Diseases R-HSA-8863678 7.025820e-02 1.153 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 7.025820e-02 1.153 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.035562e-02 1.153 0 0
DAG and IP3 signaling R-HSA-1489509 7.122507e-02 1.147 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.129065e-02 1.147 1 1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.138449e-02 1.146 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.138449e-02 1.146 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 7.154327e-02 1.145 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 7.154327e-02 1.145 0 0
Polo-like kinase mediated events R-HSA-156711 7.154327e-02 1.145 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.154327e-02 1.145 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 7.154327e-02 1.145 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.154327e-02 1.145 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.184735e-02 1.144 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.184735e-02 1.144 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 7.290821e-02 1.137 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.290821e-02 1.137 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.489431e-02 1.126 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.501885e-02 1.125 0 0
Stabilization of p53 R-HSA-69541 7.712167e-02 1.113 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.748131e-02 1.111 0 0
Regulation of pyruvate metabolism R-HSA-9861718 7.780795e-02 1.109 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.840558e-02 1.106 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.840558e-02 1.106 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.156276e-02 1.089 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.241661e-02 1.084 0 0
Integrin signaling R-HSA-354192 8.312447e-02 1.080 0 0
G-protein beta:gamma signalling R-HSA-397795 8.312447e-02 1.080 1 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 8.312447e-02 1.080 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.312447e-02 1.080 0 0
Signaling by FGFR2 R-HSA-5654738 8.376432e-02 1.077 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.389130e-02 1.076 0 0
Macroautophagy R-HSA-1632852 8.451652e-02 1.073 0 0
Aggrephagy R-HSA-9646399 8.466636e-02 1.072 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.466636e-02 1.072 0 0
Selective autophagy R-HSA-9663891 8.631357e-02 1.064 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 8.887841e-02 1.051 0 0
Type I hemidesmosome assembly R-HSA-446107 8.938464e-02 1.049 0 0
Formation of annular gap junctions R-HSA-196025 8.938464e-02 1.049 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.984213e-02 1.047 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.061499e-02 1.043 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 9.061499e-02 1.043 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.092421e-02 1.041 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.099494e-02 1.041 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.099494e-02 1.041 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 9.204973e-02 1.036 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 1.127261e-01 0.948 0 0
Regulation of gap junction activity R-HSA-191650 1.127261e-01 0.948 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.127261e-01 0.948 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.127261e-01 0.948 0 0
Gap junction degradation R-HSA-190873 1.085112e-01 0.965 0 0
WNT mediated activation of DVL R-HSA-201688 1.085112e-01 0.965 0 0
ALK mutants bind TKIs R-HSA-9700645 1.085112e-01 0.965 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.290567e-01 0.889 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.103934e-01 0.957 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.262906e-01 0.899 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.262906e-01 0.899 0 0
Phosphorylation of the APC/C R-HSA-176412 1.262906e-01 0.899 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.262906e-01 0.899 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.187228e-01 0.925 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.099194e-01 0.959 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.099194e-01 0.959 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.099194e-01 0.959 0 0
Late endosomal microautophagy R-HSA-9615710 1.213126e-01 0.916 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.010045e-01 0.996 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.247886e-01 0.904 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.247886e-01 0.904 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.338354e-01 0.873 0 0
PTEN Regulation R-HSA-6807070 1.166059e-01 0.933 1 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.385340e-01 0.858 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.385340e-01 0.858 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.385340e-01 0.858 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.385340e-01 0.858 0 0
MAP2K and MAPK activation R-HSA-5674135 1.010045e-01 0.996 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.165294e-01 0.934 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.546284e-02 1.020 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.107774e-01 0.956 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.315975e-01 0.881 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.355953e-02 1.029 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.493121e-02 1.023 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.493121e-02 1.023 0 0
Clathrin-mediated endocytosis R-HSA-8856828 9.723896e-02 1.012 0 0
Netrin-1 signaling R-HSA-373752 1.285636e-01 0.891 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.859251e-02 1.006 0 0
Degradation of CDH1 R-HSA-9766229 9.970699e-02 1.001 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.213126e-01 0.916 0 0
PLC beta mediated events R-HSA-112043 1.288915e-01 0.890 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.546284e-02 1.020 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.010727e-01 0.995 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.213126e-01 0.916 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.187228e-01 0.925 0 0
Ca-dependent events R-HSA-111996 1.097902e-01 0.959 0 0
Glycogen synthesis R-HSA-3322077 9.360490e-02 1.029 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.910245e-02 1.004 0 0
Calmodulin induced events R-HSA-111933 1.209564e-01 0.917 0 0
Post NMDA receptor activation events R-HSA-438064 1.348446e-01 0.870 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.127261e-01 0.948 0 0
MTF1 activates gene expression R-HSA-5660489 1.127261e-01 0.948 0 0
Unwinding of DNA R-HSA-176974 1.085112e-01 0.965 0 0
Interaction between L1 and Ankyrins R-HSA-445095 9.910245e-02 1.004 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.099194e-01 0.959 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.213126e-01 0.916 0 0
CaM pathway R-HSA-111997 1.209564e-01 0.917 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 9.970699e-02 1.001 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 9.970699e-02 1.001 0 0
TBC/RABGAPs R-HSA-8854214 1.189792e-01 0.925 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.385340e-01 0.858 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.288915e-01 0.890 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.228145e-01 0.911 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.374560e-01 0.862 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.290868e-01 0.889 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.103934e-01 0.957 1 1
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.323536e-01 0.878 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.315975e-01 0.881 0 0
Interferon Signaling R-HSA-913531 1.282934e-01 0.892 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.247886e-01 0.904 0 0
Pyruvate metabolism R-HSA-70268 1.348446e-01 0.870 0 0
Mitophagy R-HSA-5205647 1.010727e-01 0.995 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.010045e-01 0.996 0 0
Glycolysis R-HSA-70171 1.164829e-01 0.934 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.261517e-01 0.899 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.057954e-01 0.976 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.187228e-01 0.925 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.262830e-02 1.033 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.228145e-01 0.911 0 0
Regulation of BACH1 activity R-HSA-9708530 1.262906e-01 0.899 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.413935e-01 0.850 0 0
Opioid Signalling R-HSA-111885 1.424387e-01 0.846 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.424387e-01 0.846 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.430840e-01 0.844 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.430840e-01 0.844 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 1.430840e-01 0.844 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 1.430840e-01 0.844 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.432141e-01 0.844 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 1.444855e-01 0.840 0 0
IRS activation R-HSA-74713 1.444855e-01 0.840 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.444855e-01 0.840 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.444855e-01 0.840 0 0
NrCAM interactions R-HSA-447038 1.444855e-01 0.840 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.457466e-01 0.836 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.457466e-01 0.836 0 0
Semaphorin interactions R-HSA-373755 1.463118e-01 0.835 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 1.466502e-01 0.834 1 1
Growth hormone receptor signaling R-HSA-982772 1.466502e-01 0.834 0 0
Signaling by TGFBR3 R-HSA-9839373 1.488795e-01 0.827 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.488795e-01 0.827 0 0
Signaling by APC mutants R-HSA-4839744 1.508450e-01 0.821 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.508450e-01 0.821 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.508450e-01 0.821 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.508450e-01 0.821 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 1.508450e-01 0.821 1 1
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.542068e-01 0.812 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.572575e-01 0.803 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.587397e-01 0.799 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.597646e-01 0.797 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.606975e-01 0.794 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.606975e-01 0.794 0 0
Deadenylation of mRNA R-HSA-429947 1.615713e-01 0.792 0 0
Ion homeostasis R-HSA-5578775 1.629321e-01 0.788 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.629321e-01 0.788 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.648698e-01 0.783 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.661408e-01 0.780 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.661408e-01 0.780 0 0
Signaling by NOTCH R-HSA-157118 1.687405e-01 0.773 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.722146e-01 0.764 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.722146e-01 0.764 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.722146e-01 0.764 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.722146e-01 0.764 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.735861e-01 0.760 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.735861e-01 0.760 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.735861e-01 0.760 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.735861e-01 0.760 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.735861e-01 0.760 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.735861e-01 0.760 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.735861e-01 0.760 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.735861e-01 0.760 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.735861e-01 0.760 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.736981e-01 0.760 0 0
Signaling by AXIN mutants R-HSA-4839735 1.736981e-01 0.760 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.736981e-01 0.760 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.738815e-01 0.760 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.487360e-01 0.604 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 2.487360e-01 0.604 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.487360e-01 0.604 0 0
IKBKB deficiency causes SCID R-HSA-5602636 2.487360e-01 0.604 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.487360e-01 0.604 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 2.487360e-01 0.604 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.487360e-01 0.604 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.487360e-01 0.604 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.487360e-01 0.604 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 1.778073e-01 0.750 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.778073e-01 0.750 0 0
PDE3B signalling R-HSA-165160 1.778073e-01 0.750 0 0
PKB-mediated events R-HSA-109703 1.778073e-01 0.750 0 0
Essential pentosuria R-HSA-5662853 3.170562e-01 0.499 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.170562e-01 0.499 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.170562e-01 0.499 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.121453e-01 0.673 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.121453e-01 0.673 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.470396e-01 0.607 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.470396e-01 0.607 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.470396e-01 0.607 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 2.470396e-01 0.607 0 0
SOS-mediated signalling R-HSA-112412 2.470396e-01 0.607 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.470396e-01 0.607 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.974405e-01 0.705 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.974405e-01 0.705 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.974405e-01 0.705 0 0
Repression of WNT target genes R-HSA-4641265 1.974405e-01 0.705 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.974405e-01 0.705 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.974405e-01 0.705 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.974405e-01 0.705 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.974405e-01 0.705 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.974405e-01 0.705 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 2.821054e-01 0.550 0 0
MET receptor recycling R-HSA-8875656 2.821054e-01 0.550 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.821054e-01 0.550 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.821054e-01 0.550 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.821054e-01 0.550 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.219019e-01 0.654 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.219019e-01 0.654 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.790515e-01 0.747 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 2.469190e-01 0.607 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.469190e-01 0.607 0 0
Lipophagy R-HSA-9613354 3.170234e-01 0.499 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.723374e-01 0.565 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.723374e-01 0.565 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.096280e-01 0.679 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.980128e-01 0.526 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 2.439240e-01 0.613 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.790371e-01 0.554 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.238113e-01 0.490 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.238113e-01 0.490 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.615985e-01 0.582 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.496101e-01 0.456 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.496101e-01 0.456 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.496101e-01 0.456 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.496101e-01 0.456 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.213444e-01 0.493 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.213444e-01 0.493 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.594696e-01 0.586 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.935649e-01 0.532 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.408577e-01 0.618 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.408577e-01 0.618 0 0
Peptide chain elongation R-HSA-156902 2.209900e-01 0.656 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.490602e-01 0.604 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.776844e-01 0.556 0 0
Centrosome maturation R-HSA-380287 2.721585e-01 0.565 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.038784e-01 0.517 0 0
Formation of a pool of free 40S subunits R-HSA-72689 3.148088e-01 0.502 0 0
HCMV Early Events R-HSA-9609690 2.455573e-01 0.610 0 0
Transcription of the HIV genome R-HSA-167172 3.030715e-01 0.518 0 0
HIV Transcription Elongation R-HSA-167169 2.935649e-01 0.532 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.614406e-01 0.583 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.894002e-01 0.723 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.894002e-01 0.723 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.408212e-01 0.618 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.935649e-01 0.532 0 0
Circadian clock R-HSA-9909396 3.409445e-01 0.467 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.615985e-01 0.582 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.312884e-01 0.636 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.894002e-01 0.723 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.452521e-01 0.610 0 0
Interleukin-9 signaling R-HSA-8985947 2.821054e-01 0.550 0 0
Interleukin-21 signaling R-HSA-9020958 3.170234e-01 0.499 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.176517e-01 0.662 1 1
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.773945e-01 0.557 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.773945e-01 0.557 0 0
Attenuation phase R-HSA-3371568 2.935649e-01 0.532 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.266864e-01 0.645 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.266864e-01 0.645 0 0
Regulation of IFNG signaling R-HSA-877312 1.974405e-01 0.705 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 2.821054e-01 0.550 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.723374e-01 0.565 0 0
Budding and maturation of HIV virion R-HSA-162588 2.795561e-01 0.554 0 0
UCH proteinases R-HSA-5689603 1.843110e-01 0.734 0 0
Rap1 signalling R-HSA-392517 1.980640e-01 0.703 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.126247e-01 0.505 1 1
Peroxisomal protein import R-HSA-9033241 3.105659e-01 0.508 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.420779e-01 0.466 1 1
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.778073e-01 0.750 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.784690e-01 0.748 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.784690e-01 0.748 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.152290e-01 0.667 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.152290e-01 0.667 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.615985e-01 0.582 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.452521e-01 0.610 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.789688e-01 0.747 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.264153e-01 0.486 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.334542e-01 0.477 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.739150e-01 0.562 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.959786e-01 0.529 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.238113e-01 0.490 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 2.527258e-01 0.597 0 0
Interferon gamma signaling R-HSA-877300 3.329120e-01 0.478 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.931078e-01 0.714 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.911705e-01 0.719 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.947555e-01 0.711 0 0
DNA strand elongation R-HSA-69190 2.977465e-01 0.526 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.845028e-01 0.734 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.176517e-01 0.662 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 2.176038e-01 0.662 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 1.925957e-01 0.715 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.170234e-01 0.499 0 0
Interleukin-7 signaling R-HSA-1266695 3.426864e-01 0.465 0 0
HIV Infection R-HSA-162906 2.024207e-01 0.694 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.264153e-01 0.486 0 0
Vesicle-mediated transport R-HSA-5653656 1.926468e-01 0.715 1 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.487360e-01 0.604 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.487360e-01 0.604 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.170562e-01 0.499 0 0
C6 deamination of adenosine R-HSA-75102 3.170562e-01 0.499 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 3.170562e-01 0.499 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 1.980640e-01 0.703 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.004909e-01 0.698 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.784690e-01 0.748 0 0
Disorders of Developmental Biology R-HSA-9675151 3.238113e-01 0.490 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.303230e-01 0.638 0 0
Degradation of AXIN R-HSA-4641257 2.457384e-01 0.610 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.452521e-01 0.610 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.264153e-01 0.486 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.334542e-01 0.477 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.973161e-01 0.705 0 0
G-protein mediated events R-HSA-112040 1.845028e-01 0.734 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.161205e-01 0.500 0 0
Gene expression (Transcription) R-HSA-74160 2.963933e-01 0.528 1 0
Sema4D in semaphorin signaling R-HSA-400685 1.770727e-01 0.752 0 0
Hedgehog 'on' state R-HSA-5632684 3.420779e-01 0.466 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.486692e-01 0.458 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.323804e-01 0.478 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.173278e-01 0.663 0 0
Protein methylation R-HSA-8876725 2.723374e-01 0.565 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.170234e-01 0.499 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.946996e-01 0.711 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.366175e-01 0.626 0 0
RNA Polymerase II Transcription R-HSA-73857 2.782742e-01 0.556 1 0
HDMs demethylate histones R-HSA-3214842 1.770727e-01 0.752 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.778073e-01 0.750 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.861420e-01 0.730 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.004909e-01 0.698 0 0
Regulation of Apoptosis R-HSA-169911 2.152290e-01 0.667 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.784690e-01 0.748 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.099167e-01 0.509 0 0
HCMV Late Events R-HSA-9610379 3.157508e-01 0.501 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.196560e-01 0.658 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.395556e-01 0.469 1 1
Cytokine Signaling in Immune system R-HSA-1280215 1.769559e-01 0.752 1 0
Interleukin-6 signaling R-HSA-1059683 2.219019e-01 0.654 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 2.012780e-01 0.696 0 0
Glycogen metabolism R-HSA-8982491 2.935649e-01 0.532 0 0
Signaling by FGFR4 R-HSA-5654743 2.176038e-01 0.662 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.176038e-01 0.662 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.487360e-01 0.604 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.778073e-01 0.750 0 0
DSCAM interactions R-HSA-376172 3.170562e-01 0.499 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.170234e-01 0.499 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.170234e-01 0.499 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.496101e-01 0.456 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.057664e-01 0.687 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.795561e-01 0.554 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.161205e-01 0.500 0 0
Signaling by FGFR3 R-HSA-5654741 2.452521e-01 0.610 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.835227e-01 0.736 0 0
Signaling by TGFB family members R-HSA-9006936 1.911269e-01 0.719 0 0
PI Metabolism R-HSA-1483255 1.973161e-01 0.705 0 0
Sensory processing of sound R-HSA-9659379 2.137494e-01 0.670 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.496101e-01 0.456 0 0
Signaling by FGFR R-HSA-190236 2.462451e-01 0.609 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.121453e-01 0.673 0 0
tRNA processing in the nucleus R-HSA-6784531 2.289803e-01 0.640 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.161205e-01 0.500 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 3.161205e-01 0.500 1 1
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.831930e-01 0.548 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.919089e-01 0.535 1 0
Signaling by FGFR in disease R-HSA-1226099 2.605252e-01 0.584 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.158025e-01 0.666 0 0
Activation of BH3-only proteins R-HSA-114452 2.615985e-01 0.582 1 0
Host Interactions of HIV factors R-HSA-162909 1.749110e-01 0.757 0 0
The AIM2 inflammasome R-HSA-844615 3.170562e-01 0.499 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.470396e-01 0.607 0 0
Sodium/Proton exchangers R-HSA-425986 2.821054e-01 0.550 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.170234e-01 0.499 0 0
Assembly Of The HIV Virion R-HSA-175474 2.582200e-01 0.588 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.265836e-01 0.645 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.931078e-01 0.714 0 0
Signaling by ERBB4 R-HSA-1236394 2.605252e-01 0.584 0 0
Inositol phosphate metabolism R-HSA-1483249 2.991541e-01 0.524 0 0
MAP kinase activation R-HSA-450294 3.384509e-01 0.471 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.790371e-01 0.554 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.778073e-01 0.750 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.170234e-01 0.499 0 0
Glucose metabolism R-HSA-70326 2.731456e-01 0.564 0 0
Interleukin-12 family signaling R-HSA-447115 3.117643e-01 0.506 0 0
Influenza Infection R-HSA-168255 1.971471e-01 0.705 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.377312e-01 0.624 0 0
SARS-CoV Infections R-HSA-9679506 2.597512e-01 0.585 1 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.980128e-01 0.526 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 3.238113e-01 0.490 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.377312e-01 0.624 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.110546e-01 0.507 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.790371e-01 0.554 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.018695e-01 0.695 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.394012e-01 0.621 0 0
Insulin processing R-HSA-264876 2.096280e-01 0.679 0 0
IRE1alpha activates chaperones R-HSA-381070 2.612953e-01 0.583 0 0
Interleukin-12 signaling R-HSA-9020591 2.839468e-01 0.547 0 0
Translation of Structural Proteins R-HSA-9683701 3.264153e-01 0.486 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.515305e-01 0.454 0 0
Regulation of CDH11 function R-HSA-9762292 3.515305e-01 0.454 0 0
PI3K/AKT activation R-HSA-198203 3.515305e-01 0.454 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.515305e-01 0.454 0 0
Signal attenuation R-HSA-74749 3.515305e-01 0.454 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.515305e-01 0.454 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.515305e-01 0.454 0 0
Signaling by Leptin R-HSA-2586552 3.515305e-01 0.454 0 0
Heme signaling R-HSA-9707616 3.525344e-01 0.453 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.525344e-01 0.453 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 3.532270e-01 0.452 0 0
Signaling by SCF-KIT R-HSA-1433557 3.597171e-01 0.444 0 0
Stimuli-sensing channels R-HSA-2672351 3.599071e-01 0.444 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.640612e-01 0.439 0 0
GAB1 signalosome R-HSA-180292 3.752976e-01 0.426 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.752976e-01 0.426 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 3.752976e-01 0.426 0 0
Mismatch Repair R-HSA-5358508 3.752976e-01 0.426 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.752976e-01 0.426 0 0
Cyclin D associated events in G1 R-HSA-69231 3.764543e-01 0.424 0 0
G1 Phase R-HSA-69236 3.764543e-01 0.424 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.764543e-01 0.424 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.791671e-01 0.421 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.791671e-01 0.421 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 3.791671e-01 0.421 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.791671e-01 0.421 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.791671e-01 0.421 0 0
MET activates PTPN11 R-HSA-8865999 3.791671e-01 0.421 0 0
The IPAF inflammasome R-HSA-844623 3.791671e-01 0.421 0 0
MET interacts with TNS proteins R-HSA-8875513 3.791671e-01 0.421 0 0
Signaling by NOTCH4 R-HSA-9013694 3.817989e-01 0.418 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.854039e-01 0.414 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.854039e-01 0.414 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 3.854039e-01 0.414 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.854130e-01 0.414 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 3.854130e-01 0.414 0 0
Interleukin-2 signaling R-HSA-9020558 3.854130e-01 0.414 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.854130e-01 0.414 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.854130e-01 0.414 0 0
Synthesis of PI R-HSA-1483226 3.854130e-01 0.414 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.854130e-01 0.414 0 0
RET signaling R-HSA-8853659 3.905078e-01 0.408 0 0
G1/S-Specific Transcription R-HSA-69205 3.905078e-01 0.408 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.932066e-01 0.405 0 0
Signaling by Interleukins R-HSA-449147 3.941679e-01 0.404 0 0
Signaling by NOTCH3 R-HSA-9012852 3.945665e-01 0.404 0 0
Iron uptake and transport R-HSA-917937 3.951221e-01 0.403 0 0
The NLRP3 inflammasome R-HSA-844456 4.007730e-01 0.397 0 0
Maturation of nucleoprotein R-HSA-9694631 4.007730e-01 0.397 0 0
HIV elongation arrest and recovery R-HSA-167287 4.066540e-01 0.391 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.066540e-01 0.391 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.066540e-01 0.391 0 0
Ribosome-associated quality control R-HSA-9948299 4.087833e-01 0.389 0 0
Signaling by FGFR1 R-HSA-5654736 4.099037e-01 0.387 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.184992e-01 0.378 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.184992e-01 0.378 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.184992e-01 0.378 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.199602e-01 0.377 0 0
Translation of Structural Proteins R-HSA-9694635 4.217986e-01 0.375 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.259467e-01 0.371 0 0
Formation of definitive endoderm R-HSA-9823730 4.259467e-01 0.371 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.266357e-01 0.370 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 4.276242e-01 0.369 0 0
MET promotes cell motility R-HSA-8875878 4.276242e-01 0.369 0 0
Signaling by Erythropoietin R-HSA-9006335 4.277554e-01 0.369 0 0
mRNA Capping R-HSA-72086 4.277554e-01 0.369 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.277554e-01 0.369 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.277554e-01 0.369 1 0
Cardiac conduction R-HSA-5576891 4.309048e-01 0.366 0 0
Cilium Assembly R-HSA-5617833 4.339932e-01 0.363 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.350072e-01 0.362 0 0
PCP/CE pathway R-HSA-4086400 4.351213e-01 0.361 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 4.356325e-01 0.361 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.356325e-01 0.361 0 0
ATP sensitive Potassium channels R-HSA-1296025 4.356325e-01 0.361 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.356325e-01 0.361 0 0
Dopamine receptors R-HSA-390651 4.356325e-01 0.361 0 0
NGF-stimulated transcription R-HSA-9031628 4.432552e-01 0.353 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.451197e-01 0.352 0 0
RAS processing R-HSA-9648002 4.460241e-01 0.351 0 0
Plasma lipoprotein clearance R-HSA-8964043 4.460241e-01 0.351 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.486561e-01 0.348 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.506537e-01 0.346 0 0
Interleukin-15 signaling R-HSA-8983432 4.506537e-01 0.346 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.506537e-01 0.346 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.506537e-01 0.346 0 0
Disorders of Nervous System Development R-HSA-9697154 4.506537e-01 0.346 0 0
Pervasive developmental disorders R-HSA-9005895 4.506537e-01 0.346 0 0
MET activates RAS signaling R-HSA-8851805 4.506537e-01 0.346 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 4.506537e-01 0.346 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.507391e-01 0.346 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.597755e-01 0.337 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.642716e-01 0.333 0 0
Interleukin-2 family signaling R-HSA-451927 4.642716e-01 0.333 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.642716e-01 0.333 0 0
Interleukin-17 signaling R-HSA-448424 4.660139e-01 0.332 0 0
L1CAM interactions R-HSA-373760 4.689648e-01 0.329 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.708040e-01 0.327 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 4.708040e-01 0.327 0 0
PI3K Cascade R-HSA-109704 4.761713e-01 0.322 0 0
FOXO-mediated transcription R-HSA-9614085 4.776900e-01 0.321 1 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.800276e-01 0.319 0 0
Formation of axial mesoderm R-HSA-9796292 4.817725e-01 0.317 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 4.817725e-01 0.317 0 0
Frs2-mediated activation R-HSA-170968 4.817725e-01 0.317 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.817725e-01 0.317 0 0
Maturation of nucleoprotein R-HSA-9683610 4.817725e-01 0.317 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.817725e-01 0.317 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.825956e-01 0.316 0 0
Cellular response to chemical stress R-HSA-9711123 4.840179e-01 0.315 1 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.858131e-01 0.314 0 0
Platelet degranulation R-HSA-114608 4.859278e-01 0.313 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 4.869654e-01 0.313 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 4.869654e-01 0.313 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.869654e-01 0.313 0 0
Activation of AKT2 R-HSA-165158 4.869654e-01 0.313 0 0
PTK6 Down-Regulation R-HSA-8849472 4.869654e-01 0.313 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.869654e-01 0.313 0 0
Reelin signalling pathway R-HSA-8866376 4.869654e-01 0.313 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.869654e-01 0.313 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 4.869654e-01 0.313 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 4.869654e-01 0.313 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.869654e-01 0.313 0 0
Hedgehog 'off' state R-HSA-5610787 4.894945e-01 0.310 0 0
ABC-family proteins mediated transport R-HSA-382556 4.894945e-01 0.310 0 0
Signaling by WNT in cancer R-HSA-4791275 4.896700e-01 0.310 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 4.989119e-01 0.302 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 4.989119e-01 0.302 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.001824e-01 0.301 0 0
HIV Transcription Initiation R-HSA-167161 5.001824e-01 0.301 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.001824e-01 0.301 0 0
Interleukin-1 signaling R-HSA-9020702 5.012376e-01 0.300 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.012376e-01 0.300 1 0
Ca2+ pathway R-HSA-4086398 5.077603e-01 0.294 0 0
Removal of the Flap Intermediate R-HSA-69166 5.117779e-01 0.291 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.117779e-01 0.291 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.117779e-01 0.291 0 0
Regulation of KIT signaling R-HSA-1433559 5.117779e-01 0.291 0 0
Signal regulatory protein family interactions R-HSA-391160 5.117779e-01 0.291 0 0
Physiological factors R-HSA-5578768 5.117779e-01 0.291 0 0
Ion channel transport R-HSA-983712 5.148255e-01 0.288 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 5.221812e-01 0.282 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.221812e-01 0.282 0 0
Syndecan interactions R-HSA-3000170 5.221812e-01 0.282 0 0
Smooth Muscle Contraction R-HSA-445355 5.243817e-01 0.280 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.293681e-01 0.276 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.293681e-01 0.276 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.293681e-01 0.276 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 5.293681e-01 0.276 0 0
IGF1R signaling cascade R-HSA-2428924 5.300243e-01 0.276 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.336320e-01 0.273 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.336320e-01 0.273 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.336320e-01 0.273 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.336320e-01 0.273 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.336320e-01 0.273 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.336320e-01 0.273 0 0
Terminal pathway of complement R-HSA-166665 5.336320e-01 0.273 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.336320e-01 0.273 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.336320e-01 0.273 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.336320e-01 0.273 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.336320e-01 0.273 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.336320e-01 0.273 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.336320e-01 0.273 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.336320e-01 0.273 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 5.336320e-01 0.273 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.336320e-01 0.273 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.336320e-01 0.273 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.336320e-01 0.273 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.351267e-01 0.272 0 0
Response of Mtb to phagocytosis R-HSA-9637690 5.351267e-01 0.272 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 5.360095e-01 0.271 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.406151e-01 0.267 0 0
Erythropoietin activates RAS R-HSA-9027284 5.406151e-01 0.267 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 5.406151e-01 0.267 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.406151e-01 0.267 0 0
Biotin transport and metabolism R-HSA-196780 5.406151e-01 0.267 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.406151e-01 0.267 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.406151e-01 0.267 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.406151e-01 0.267 0 0
DNA Damage Reversal R-HSA-73942 5.406151e-01 0.267 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 5.436091e-01 0.265 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.444348e-01 0.264 0 0
Cellular response to hypoxia R-HSA-1234174 5.444348e-01 0.264 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.448460e-01 0.264 0 0
Interleukin-6 family signaling R-HSA-6783589 5.448460e-01 0.264 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.486395e-01 0.261 0 0
Signaling by NOTCH2 R-HSA-1980145 5.486395e-01 0.261 0 0
RMTs methylate histone arginines R-HSA-3214858 5.521751e-01 0.258 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 5.521751e-01 0.258 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.555044e-01 0.255 0 0
Eukaryotic Translation Termination R-HSA-72764 5.555044e-01 0.255 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.575138e-01 0.254 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 5.587258e-01 0.253 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.672763e-01 0.246 0 0
PERK regulates gene expression R-HSA-381042 5.674891e-01 0.246 0 0
Killing mechanisms R-HSA-9664420 5.682484e-01 0.245 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.682484e-01 0.245 0 0
Prolonged ERK activation events R-HSA-169893 5.682484e-01 0.245 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.682484e-01 0.245 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.682484e-01 0.245 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.689127e-01 0.245 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.707066e-01 0.244 1 0
ABC transporter disorders R-HSA-5619084 5.747348e-01 0.241 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.760563e-01 0.240 0 0
Signaling by LTK in cancer R-HSA-9842640 5.760563e-01 0.240 0 0
STAT5 Activation R-HSA-9645135 5.760563e-01 0.240 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.760563e-01 0.240 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.760563e-01 0.240 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 5.760563e-01 0.240 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.760563e-01 0.240 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 5.760563e-01 0.240 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 5.760563e-01 0.240 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.760563e-01 0.240 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.760563e-01 0.240 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.809986e-01 0.236 0 0
IRS-mediated signalling R-HSA-112399 5.856499e-01 0.232 0 0
FGFR2 mutant receptor activation R-HSA-1839126 5.858937e-01 0.232 0 0
Regulated Necrosis R-HSA-5218859 5.864871e-01 0.232 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 5.882283e-01 0.230 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.882283e-01 0.230 0 0
TRP channels R-HSA-3295583 5.882283e-01 0.230 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.882283e-01 0.230 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.946581e-01 0.226 0 0
Phase 2 - plateau phase R-HSA-5576893 5.946581e-01 0.226 0 0
Coenzyme A biosynthesis R-HSA-196783 5.946581e-01 0.226 0 0
Response to metal ions R-HSA-5660526 5.946581e-01 0.226 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.088962e-01 0.215 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.134200e-01 0.212 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.134588e-01 0.212 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.134588e-01 0.212 0 0
TCR signaling R-HSA-202403 6.134588e-01 0.212 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.146236e-01 0.211 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.146236e-01 0.211 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.146236e-01 0.211 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.146236e-01 0.211 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.146236e-01 0.211 0 0
Netrin mediated repulsion signals R-HSA-418886 6.146236e-01 0.211 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.146236e-01 0.211 0 0
Recycling of eIF2:GDP R-HSA-72731 6.146236e-01 0.211 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.146236e-01 0.211 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.146236e-01 0.211 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.146236e-01 0.211 0 0
VLDL clearance R-HSA-8964046 6.146236e-01 0.211 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.146236e-01 0.211 0 0
Maturation of replicase proteins R-HSA-9694301 6.146236e-01 0.211 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.198383e-01 0.208 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 6.198383e-01 0.208 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.198383e-01 0.208 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.198383e-01 0.208 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.198383e-01 0.208 0 0
Selenocysteine synthesis R-HSA-2408557 6.240215e-01 0.205 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.287983e-01 0.201 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.287983e-01 0.201 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.287983e-01 0.201 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.287983e-01 0.201 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.287983e-01 0.201 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.288589e-01 0.201 0 0
Insulin receptor recycling R-HSA-77387 6.288589e-01 0.201 0 0
Inflammasomes R-HSA-622312 6.288589e-01 0.201 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.324234e-01 0.199 0 0
Signaling by Insulin receptor R-HSA-74752 6.357977e-01 0.197 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 6.357977e-01 0.197 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 6.382604e-01 0.195 0 0
Signaling by ALK R-HSA-201556 6.382604e-01 0.195 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.393791e-01 0.194 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.437939e-01 0.191 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.437939e-01 0.191 0 0
Platelet sensitization by LDL R-HSA-432142 6.437939e-01 0.191 0 0
Viral mRNA Translation R-HSA-192823 6.456111e-01 0.190 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.473758e-01 0.189 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 6.481061e-01 0.188 0 0
DARPP-32 events R-HSA-180024 6.481061e-01 0.188 0 0
phospho-PLA2 pathway R-HSA-111995 6.496844e-01 0.187 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.496844e-01 0.187 0 0
Adrenoceptors R-HSA-390696 6.496844e-01 0.187 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.496844e-01 0.187 0 0
Co-stimulation by ICOS R-HSA-9927354 6.496844e-01 0.187 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.496844e-01 0.187 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 6.496844e-01 0.187 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 6.496844e-01 0.187 0 0
Alpha-defensins R-HSA-1462054 6.496844e-01 0.187 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.537175e-01 0.185 0 0
MHC class II antigen presentation R-HSA-2132295 6.537175e-01 0.185 0 0
HCMV Infection R-HSA-9609646 6.622697e-01 0.179 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.665394e-01 0.176 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.665394e-01 0.176 0 0
Specification of the neural plate border R-HSA-9834899 6.665394e-01 0.176 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.665394e-01 0.176 0 0
Interleukin-37 signaling R-HSA-9008059 6.666322e-01 0.176 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 6.666322e-01 0.176 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 6.666322e-01 0.176 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 6.744200e-01 0.171 0 0
Developmental Cell Lineages R-HSA-9734767 6.760555e-01 0.170 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.763583e-01 0.170 0 0
Generic Transcription Pathway R-HSA-212436 6.768842e-01 0.169 1 0
Interleukin-1 processing R-HSA-448706 6.815573e-01 0.166 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.815573e-01 0.166 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.815573e-01 0.166 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.815573e-01 0.166 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.815573e-01 0.166 0 0
mRNA Editing R-HSA-75072 6.815573e-01 0.166 0 0
ARMS-mediated activation R-HSA-170984 6.815573e-01 0.166 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 6.815573e-01 0.166 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.815573e-01 0.166 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.815573e-01 0.166 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.815573e-01 0.166 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.815573e-01 0.166 0 0
Insulin receptor signalling cascade R-HSA-74751 6.820495e-01 0.166 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.880967e-01 0.162 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.880967e-01 0.162 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.880967e-01 0.162 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.880967e-01 0.162 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.880967e-01 0.162 0 0
Nephrin family interactions R-HSA-373753 6.880967e-01 0.162 0 0
Signaling by NODAL R-HSA-1181150 6.880967e-01 0.162 0 0
Protein hydroxylation R-HSA-9629569 6.880967e-01 0.162 0 0
Signal transduction by L1 R-HSA-445144 6.880967e-01 0.162 0 0
Signaling by NOTCH1 R-HSA-1980143 6.881448e-01 0.162 0 0
Adaptive Immune System R-HSA-1280218 6.998619e-01 0.155 1 0
Cellular response to starvation R-HSA-9711097 7.022565e-01 0.154 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.060696e-01 0.151 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.060696e-01 0.151 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 7.061565e-01 0.151 0 0
G-protein activation R-HSA-202040 7.084936e-01 0.150 0 0
Lagging Strand Synthesis R-HSA-69186 7.084936e-01 0.150 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.084936e-01 0.150 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.084936e-01 0.150 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.084936e-01 0.150 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 7.087066e-01 0.150 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.102144e-01 0.149 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.102144e-01 0.149 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.102144e-01 0.149 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.105320e-01 0.148 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.105320e-01 0.148 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.105320e-01 0.148 0 0
Formation of apoptosome R-HSA-111458 7.105320e-01 0.148 0 0
Binding and entry of HIV virion R-HSA-173107 7.105320e-01 0.148 0 0
DNA replication initiation R-HSA-68952 7.105320e-01 0.148 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 7.105320e-01 0.148 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.105320e-01 0.148 0 0
2-LTR circle formation R-HSA-164843 7.105320e-01 0.148 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.105320e-01 0.148 0 0
Interleukin-27 signaling R-HSA-9020956 7.105320e-01 0.148 0 0
Sperm Motility And Taxes R-HSA-1300642 7.105320e-01 0.148 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.105320e-01 0.148 0 0
Signaling by NTRKs R-HSA-166520 7.121398e-01 0.147 0 0
Signaling by Hedgehog R-HSA-5358351 7.145078e-01 0.146 0 0
ER-Phagosome pathway R-HSA-1236974 7.153539e-01 0.145 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.154821e-01 0.145 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 7.160153e-01 0.145 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 7.178880e-01 0.144 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.178880e-01 0.144 0 0
Downstream TCR signaling R-HSA-202424 7.255475e-01 0.139 0 0
Attachment and Entry R-HSA-9694614 7.277628e-01 0.138 0 0
PKR-mediated signaling R-HSA-9833482 7.324638e-01 0.135 0 0
Resolution of D-Loop Structures R-HSA-5693537 7.335511e-01 0.135 0 0
Developmental Biology R-HSA-1266738 7.340386e-01 0.134 1 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.368719e-01 0.133 0 0
LGI-ADAM interactions R-HSA-5682910 7.368719e-01 0.133 0 0
vRNP Assembly R-HSA-192905 7.368719e-01 0.133 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.368719e-01 0.133 0 0
Bicarbonate transporters R-HSA-425381 7.368719e-01 0.133 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.368719e-01 0.133 0 0
PECAM1 interactions R-HSA-210990 7.368719e-01 0.133 0 0
Suppression of apoptosis R-HSA-9635465 7.368719e-01 0.133 0 0
Transport of RCbl within the body R-HSA-9758890 7.368719e-01 0.133 0 0
Interleukin-1 family signaling R-HSA-446652 7.431870e-01 0.129 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.459406e-01 0.127 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.459406e-01 0.127 0 0
Signaling by KIT in disease R-HSA-9669938 7.459406e-01 0.127 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.459406e-01 0.127 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.459406e-01 0.127 0 0
eNOS activation R-HSA-203615 7.485195e-01 0.126 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.485195e-01 0.126 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.485195e-01 0.126 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.511594e-01 0.124 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.526238e-01 0.123 0 0
EPH-Ephrin signaling R-HSA-2682334 7.546331e-01 0.122 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.608165e-01 0.119 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.608165e-01 0.119 0 0
Integration of provirus R-HSA-162592 7.608165e-01 0.119 0 0
ERKs are inactivated R-HSA-202670 7.608165e-01 0.119 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.608165e-01 0.119 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.608165e-01 0.119 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 7.608165e-01 0.119 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.608165e-01 0.119 0 0
Activation of RAC1 R-HSA-428540 7.608165e-01 0.119 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.608165e-01 0.119 0 0
Neddylation R-HSA-8951664 7.624810e-01 0.118 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.627070e-01 0.118 0 0
Transferrin endocytosis and recycling R-HSA-917977 7.628066e-01 0.118 0 0
Signalling to ERKs R-HSA-187687 7.628066e-01 0.118 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.628066e-01 0.118 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.630660e-01 0.117 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.630660e-01 0.117 0 0
Interleukin-20 family signaling R-HSA-8854691 7.630660e-01 0.117 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.630660e-01 0.117 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.679061e-01 0.115 0 0
Recycling pathway of L1 R-HSA-437239 7.679061e-01 0.115 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.727751e-01 0.112 0 0
RSV-host interactions R-HSA-9833110 7.740522e-01 0.111 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.764273e-01 0.110 0 0
RNA Polymerase III Transcription R-HSA-74158 7.764273e-01 0.110 0 0
RUNX2 regulates bone development R-HSA-8941326 7.764273e-01 0.110 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.791800e-01 0.108 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 7.825691e-01 0.106 0 0
Maple Syrup Urine Disease R-HSA-9865114 7.825834e-01 0.106 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 7.825834e-01 0.106 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 7.825834e-01 0.106 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.825834e-01 0.106 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.825834e-01 0.106 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.825834e-01 0.106 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.825834e-01 0.106 0 0
Interleukin-35 Signalling R-HSA-8984722 7.825834e-01 0.106 0 0
Signaling by LTK R-HSA-9842663 7.825834e-01 0.106 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.825834e-01 0.106 0 0
Polymerase switching R-HSA-69091 7.825834e-01 0.106 0 0
Leading Strand Synthesis R-HSA-69109 7.825834e-01 0.106 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.825834e-01 0.106 0 0
OAS antiviral response R-HSA-8983711 7.825834e-01 0.106 0 0
Interferon alpha/beta signaling R-HSA-909733 7.836472e-01 0.106 0 0
Gap junction trafficking and regulation R-HSA-157858 7.911493e-01 0.102 0 0
ROS and RNS production in phagocytes R-HSA-1222556 7.920804e-01 0.101 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.943247e-01 0.100 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.943247e-01 0.100 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.943247e-01 0.100 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.943247e-01 0.100 0 0
Tight junction interactions R-HSA-420029 7.943247e-01 0.100 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 7.943247e-01 0.100 0 0
Laminin interactions R-HSA-3000157 7.943247e-01 0.100 0 0
Hyaluronan degradation R-HSA-2160916 7.943247e-01 0.100 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.943247e-01 0.100 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.956089e-01 0.099 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.963339e-01 0.099 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.017377e-01 0.096 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.017377e-01 0.096 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.023706e-01 0.096 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.023706e-01 0.096 0 0
Chylomicron remodeling R-HSA-8963901 8.023706e-01 0.096 0 0
Processing of SMDT1 R-HSA-8949664 8.023706e-01 0.096 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 8.023706e-01 0.096 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.023706e-01 0.096 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.023706e-01 0.096 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.023706e-01 0.096 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.023706e-01 0.096 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.074524e-01 0.093 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.085432e-01 0.092 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.085432e-01 0.092 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.085432e-01 0.092 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.085432e-01 0.092 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.085432e-01 0.092 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.129646e-01 0.090 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.129646e-01 0.090 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.134640e-01 0.090 0 0
Ion transport by P-type ATPases R-HSA-936837 8.147900e-01 0.089 0 0
Neuronal System R-HSA-112316 8.174777e-01 0.088 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.203580e-01 0.086 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.203580e-01 0.086 0 0
Hydrolysis of LPC R-HSA-1483115 8.203580e-01 0.086 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.203580e-01 0.086 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.203580e-01 0.086 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.203580e-01 0.086 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.218785e-01 0.085 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.218785e-01 0.085 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.218785e-01 0.085 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.224686e-01 0.085 0 0
Diseases of Immune System R-HSA-5260271 8.245970e-01 0.084 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.245970e-01 0.084 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.308659e-01 0.080 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.320064e-01 0.080 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 8.320064e-01 0.080 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.329216e-01 0.079 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.329216e-01 0.079 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.343735e-01 0.079 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.343735e-01 0.079 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.366864e-01 0.077 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.367092e-01 0.077 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.367092e-01 0.077 0 0
Events associated with phagocytolytic activity of PMN cells R-HSA-8941413 8.367092e-01 0.077 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.367092e-01 0.077 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.367092e-01 0.077 0 0
Formation of the anterior neural plate R-HSA-9823739 8.367092e-01 0.077 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.387836e-01 0.076 0 0
Immune System R-HSA-168256 8.397871e-01 0.076 1 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.451640e-01 0.073 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 8.451640e-01 0.073 0 0
Platelet calcium homeostasis R-HSA-418360 8.460707e-01 0.073 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 8.460707e-01 0.073 0 0
Glucagon-type ligand receptors R-HSA-420092 8.460707e-01 0.073 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.488055e-01 0.071 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.515730e-01 0.070 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.515730e-01 0.070 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.515730e-01 0.070 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.515730e-01 0.070 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.515730e-01 0.070 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.515730e-01 0.070 0 0
Differentiation of T cells R-HSA-9945266 8.515730e-01 0.070 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.515730e-01 0.070 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.515730e-01 0.070 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.515730e-01 0.070 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.515730e-01 0.070 0 0
Attachment and Entry R-HSA-9678110 8.515730e-01 0.070 0 0
Protein folding R-HSA-391251 8.522353e-01 0.069 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.539846e-01 0.069 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.546395e-01 0.068 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.564515e-01 0.067 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.570118e-01 0.067 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.570118e-01 0.067 0 0
Viral Infection Pathways R-HSA-9824446 8.615505e-01 0.065 1 0
Cytoprotection by HMOX1 R-HSA-9707564 8.637914e-01 0.064 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.650846e-01 0.063 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.650846e-01 0.063 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.650846e-01 0.063 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.650846e-01 0.063 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.650846e-01 0.063 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 8.650846e-01 0.063 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.650846e-01 0.063 0 0
Passive transport by Aquaporins R-HSA-432047 8.650846e-01 0.063 0 0
Formation of xylulose-5-phosphate R-HSA-5661270 8.650846e-01 0.063 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.672374e-01 0.062 0 0
Cargo concentration in the ER R-HSA-5694530 8.672374e-01 0.062 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.672374e-01 0.062 0 0
Downstream signal transduction R-HSA-186763 8.672374e-01 0.062 0 0
Gap junction trafficking R-HSA-190828 8.720784e-01 0.059 0 0
Proteasome assembly R-HSA-9907900 8.720784e-01 0.059 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.734839e-01 0.059 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.767871e-01 0.057 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.767871e-01 0.057 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.767871e-01 0.057 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.773669e-01 0.057 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.773669e-01 0.057 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.773669e-01 0.057 0 0
GDP-fucose biosynthesis R-HSA-6787639 8.773669e-01 0.057 0 0
Choline catabolism R-HSA-6798163 8.773669e-01 0.057 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.773669e-01 0.057 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.774725e-01 0.057 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 8.780254e-01 0.056 0 0
Regulation of beta-cell development R-HSA-186712 8.806278e-01 0.055 1 0
COPI-mediated anterograde transport R-HSA-6807878 8.827662e-01 0.054 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.856646e-01 0.053 0 0
Cardiogenesis R-HSA-9733709 8.856992e-01 0.053 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.876397e-01 0.052 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.876397e-01 0.052 0 0
Diseases of DNA repair R-HSA-9675135 8.876397e-01 0.052 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.885318e-01 0.051 0 0
Ephrin signaling R-HSA-3928664 8.885318e-01 0.051 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.885318e-01 0.051 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.885318e-01 0.051 0 0
Apoptotic factor-mediated response R-HSA-111471 8.885318e-01 0.051 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.885318e-01 0.051 0 0
Neutrophil degranulation R-HSA-6798695 8.898966e-01 0.051 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.940106e-01 0.049 0 0
Heme degradation R-HSA-189483 8.940106e-01 0.049 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.940106e-01 0.049 0 0
Toll-like Receptor Cascades R-HSA-168898 8.973483e-01 0.047 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.986808e-01 0.046 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 8.986808e-01 0.046 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.986808e-01 0.046 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.986808e-01 0.046 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.986808e-01 0.046 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.017567e-01 0.045 0 0
Signal amplification R-HSA-392518 9.017567e-01 0.045 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.017567e-01 0.045 0 0
Hyaluronan metabolism R-HSA-2142845 9.017567e-01 0.045 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.017567e-01 0.045 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.079062e-01 0.042 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.079062e-01 0.042 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.079062e-01 0.042 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.079062e-01 0.042 0 0
Pregnenolone biosynthesis R-HSA-196108 9.079062e-01 0.042 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.089716e-01 0.041 0 0
Integrin cell surface interactions R-HSA-216083 9.117296e-01 0.040 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.162922e-01 0.038 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.162922e-01 0.038 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.162922e-01 0.038 0 0
ERK/MAPK targets R-HSA-198753 9.162922e-01 0.038 0 0
Abacavir metabolism R-HSA-2161541 9.162922e-01 0.038 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.162922e-01 0.038 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.162922e-01 0.038 0 0
Basigin interactions R-HSA-210991 9.162922e-01 0.038 0 0
Integration of energy metabolism R-HSA-163685 9.165305e-01 0.038 0 0
Voltage gated Potassium channels R-HSA-1296072 9.219361e-01 0.035 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.223320e-01 0.035 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.239150e-01 0.034 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.239150e-01 0.034 0 0
Ribavirin ADME R-HSA-9755088 9.239150e-01 0.034 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.239150e-01 0.034 0 0
Serine metabolism R-HSA-977347 9.239150e-01 0.034 0 0
Glutathione synthesis and recycling R-HSA-174403 9.239150e-01 0.034 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.239150e-01 0.034 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.239150e-01 0.034 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.246484e-01 0.034 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.254704e-01 0.034 0 0
Elastic fibre formation R-HSA-1566948 9.277462e-01 0.033 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.277462e-01 0.033 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.277462e-01 0.033 0 0
Selenoamino acid metabolism R-HSA-2408522 9.281185e-01 0.032 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.308440e-01 0.031 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.308440e-01 0.031 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 9.308440e-01 0.031 0 0
Notch-HLH transcription pathway R-HSA-350054 9.308440e-01 0.031 0 0
Ethanol oxidation R-HSA-71384 9.308440e-01 0.031 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.308440e-01 0.031 0 0
LDL clearance R-HSA-8964038 9.308440e-01 0.031 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.331460e-01 0.030 0 0
Protein localization R-HSA-9609507 9.333033e-01 0.030 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.371424e-01 0.028 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.371424e-01 0.028 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.371424e-01 0.028 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.371424e-01 0.028 0 0
Carnitine shuttle R-HSA-200425 9.371424e-01 0.028 0 0
Generation of second messenger molecules R-HSA-202433 9.381619e-01 0.028 0 0
G alpha (z) signalling events R-HSA-418597 9.386202e-01 0.028 0 0
Paracetamol ADME R-HSA-9753281 9.386202e-01 0.028 0 0
Maturation of spike protein R-HSA-9694548 9.428192e-01 0.026 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.428675e-01 0.026 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.428675e-01 0.026 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.428675e-01 0.026 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 9.428675e-01 0.026 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.428675e-01 0.026 0 0
Complex III assembly R-HSA-9865881 9.428675e-01 0.026 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.428675e-01 0.026 0 0
rRNA processing R-HSA-72312 9.455716e-01 0.024 0 0
tRNA processing R-HSA-72306 9.465123e-01 0.024 0 0
Regulation of insulin secretion R-HSA-422356 9.468787e-01 0.024 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.480715e-01 0.023 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.480715e-01 0.023 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.480715e-01 0.023 0 0
G protein gated Potassium channels R-HSA-1296059 9.480715e-01 0.023 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.480715e-01 0.023 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.480715e-01 0.023 0 0
Fertilization R-HSA-1187000 9.480715e-01 0.023 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.480715e-01 0.023 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.480715e-01 0.023 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.487738e-01 0.023 0 0
Formation of the cornified envelope R-HSA-6809371 9.508631e-01 0.022 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.511511e-01 0.022 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.511511e-01 0.022 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.513853e-01 0.022 0 0
MET activates PTK2 signaling R-HSA-8874081 9.528017e-01 0.021 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.528017e-01 0.021 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.528017e-01 0.021 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.528017e-01 0.021 0 0
Abacavir ADME R-HSA-2161522 9.528017e-01 0.021 0 0
Extension of Telomeres R-HSA-180786 9.535344e-01 0.021 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.535344e-01 0.021 0 0
Transmission across Chemical Synapses R-HSA-112315 9.535907e-01 0.021 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.554094e-01 0.020 0 0
Gastrulation R-HSA-9758941 9.557381e-01 0.020 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.571013e-01 0.019 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.571013e-01 0.019 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.571013e-01 0.019 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.571013e-01 0.019 0 0
Triglyceride biosynthesis R-HSA-75109 9.571013e-01 0.019 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.571013e-01 0.019 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.583156e-01 0.018 0 0
Amine ligand-binding receptors R-HSA-375280 9.583156e-01 0.018 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.605874e-01 0.017 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.608238e-01 0.017 0 0
Telomere Extension By Telomerase R-HSA-171319 9.610095e-01 0.017 0 0
Pyrimidine salvage R-HSA-73614 9.610095e-01 0.017 0 0
Pyroptosis R-HSA-5620971 9.610095e-01 0.017 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.615089e-01 0.017 0 0
Somitogenesis R-HSA-9824272 9.615089e-01 0.017 0 0
Parasite infection R-HSA-9664407 9.625542e-01 0.017 0 0
Leishmania phagocytosis R-HSA-9664417 9.625542e-01 0.017 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.625542e-01 0.017 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.645618e-01 0.016 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.645618e-01 0.016 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.645618e-01 0.016 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.650052e-01 0.015 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.650052e-01 0.015 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.656234e-01 0.015 0 0
Translation R-HSA-72766 9.659891e-01 0.015 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.672051e-01 0.014 0 0
DAP12 signaling R-HSA-2424491 9.677907e-01 0.014 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.677907e-01 0.014 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.677907e-01 0.014 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.677907e-01 0.014 0 0
Neurotransmitter clearance R-HSA-112311 9.677907e-01 0.014 0 0
Platelet homeostasis R-HSA-418346 9.681287e-01 0.014 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.697105e-01 0.013 0 0
Gluconeogenesis R-HSA-70263 9.697397e-01 0.013 0 0
Metal ion SLC transporters R-HSA-425410 9.697397e-01 0.013 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.707256e-01 0.013 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.709073e-01 0.013 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.713318e-01 0.013 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.717959e-01 0.012 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.720850e-01 0.012 0 0
HS-GAG degradation R-HSA-2024096 9.733932e-01 0.012 0 0
Azathioprine ADME R-HSA-9748787 9.742543e-01 0.011 0 0
Potassium Channels R-HSA-1296071 9.746505e-01 0.011 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.758178e-01 0.011 0 0
Extracellular matrix organization R-HSA-1474244 9.775251e-01 0.010 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.780217e-01 0.010 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.780217e-01 0.010 0 0
Glutamate and glutamine metabolism R-HSA-8964539 9.780217e-01 0.010 0 0
Phospholipid metabolism R-HSA-1483257 9.793159e-01 0.009 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.800248e-01 0.009 0 0
Gap junction assembly R-HSA-190861 9.800248e-01 0.009 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.800248e-01 0.009 0 0
ECM proteoglycans R-HSA-3000178 9.804197e-01 0.009 0 0
Metabolism of cofactors R-HSA-8978934 9.804197e-01 0.009 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.808151e-01 0.008 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.818454e-01 0.008 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.818454e-01 0.008 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.818454e-01 0.008 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.818454e-01 0.008 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.828737e-01 0.008 0 0
HS-GAG biosynthesis R-HSA-2022928 9.835002e-01 0.007 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.835002e-01 0.007 0 0
Glycosphingolipid transport R-HSA-9845576 9.835002e-01 0.007 0 0
GPVI-mediated activation cascade R-HSA-114604 9.835002e-01 0.007 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.835002e-01 0.007 0 0
Triglyceride catabolism R-HSA-163560 9.835002e-01 0.007 0 0
Neurotransmitter release cycle R-HSA-112310 9.846729e-01 0.007 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.850043e-01 0.007 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.850043e-01 0.007 0 0
NCAM1 interactions R-HSA-419037 9.850043e-01 0.007 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.850043e-01 0.007 0 0
Lysine catabolism R-HSA-71064 9.850043e-01 0.007 0 0
Collagen chain trimerization R-HSA-8948216 9.850043e-01 0.007 0 0
Mitochondrial biogenesis R-HSA-1592230 9.853473e-01 0.006 0 0
Peptide hormone metabolism R-HSA-2980736 9.853473e-01 0.006 0 0
Synthesis of PA R-HSA-1483166 9.854705e-01 0.006 0 0
Purine salvage R-HSA-74217 9.863713e-01 0.006 0 0
Leishmania infection R-HSA-9658195 9.874285e-01 0.005 0 0
Parasitic Infection Pathways R-HSA-9824443 9.874285e-01 0.005 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.876138e-01 0.005 0 0
Triglyceride metabolism R-HSA-8979227 9.876825e-01 0.005 0 0
Cholesterol biosynthesis R-HSA-191273 9.883721e-01 0.005 0 0
RAB geranylgeranylation R-HSA-8873719 9.886618e-01 0.005 0 0
tRNA Aminoacylation R-HSA-379724 9.886618e-01 0.005 0 0
Metabolism of polyamines R-HSA-351202 9.886618e-01 0.005 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.886618e-01 0.005 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.887431e-01 0.005 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.887431e-01 0.005 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.887431e-01 0.005 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.887431e-01 0.005 0 0
Collagen formation R-HSA-1474290 9.891695e-01 0.005 0 0
Aquaporin-mediated transport R-HSA-445717 9.895650e-01 0.005 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.895650e-01 0.005 0 0
Collagen degradation R-HSA-1442490 9.895650e-01 0.005 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.897695e-01 0.004 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.897695e-01 0.004 0 0
Potential therapeutics for SARS R-HSA-9679191 9.903641e-01 0.004 0 0
Signaling by PDGF R-HSA-186797 9.903978e-01 0.004 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.907023e-01 0.004 0 0
Intra-Golgi traffic R-HSA-6811438 9.907023e-01 0.004 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.907023e-01 0.004 0 0
SLC transporter disorders R-HSA-5619102 9.915399e-01 0.004 0 0
Activation of GABAB receptors R-HSA-991365 9.915502e-01 0.004 0 0
GABA B receptor activation R-HSA-977444 9.915502e-01 0.004 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.915502e-01 0.004 0 0
Defensins R-HSA-1461973 9.923207e-01 0.003 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.923207e-01 0.003 0 0
Pyrimidine catabolism R-HSA-73621 9.923207e-01 0.003 0 0
DAP12 interactions R-HSA-2172127 9.930211e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.930211e-01 0.003 0 0
Hemostasis R-HSA-109582 9.931124e-01 0.003 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.936576e-01 0.003 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.936576e-01 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.941398e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.941892e-01 0.003 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.942361e-01 0.003 0 0
Synthesis of PC R-HSA-1483191 9.947618e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.950907e-01 0.002 0 0
Intraflagellar transport R-HSA-5620924 9.952397e-01 0.002 0 0
GPER1 signaling R-HSA-9634597 9.952397e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.952397e-01 0.002 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.954885e-01 0.002 0 0
Retinoid metabolism and transport R-HSA-975634 9.954885e-01 0.002 0 0
Metabolism of porphyrins R-HSA-189445 9.954885e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.956739e-01 0.002 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.956992e-01 0.002 0 0
Purine catabolism R-HSA-74259 9.958545e-01 0.002 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.959989e-01 0.002 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.960686e-01 0.002 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.964273e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.964273e-01 0.002 0 0
The phototransduction cascade R-HSA-2514856 9.964273e-01 0.002 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.968521e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.970495e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.972091e-01 0.001 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.974732e-01 0.001 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.975115e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.975449e-01 0.001 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.977018e-01 0.001 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.977154e-01 0.001 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.977858e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.979879e-01 0.001 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.980380e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.980750e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.981876e-01 0.001 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.983385e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.983385e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.983896e-01 0.001 0 0
GABA receptor activation R-HSA-977443 9.984902e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.984902e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.986280e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.992276e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.992276e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.992276e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.992276e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.992981e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.993075e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.993614e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.994205e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.994776e-01 0.000 1 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.995386e-01 0.000 0 0
Adipogenesis R-HSA-9843745 9.995492e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.996050e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.996081e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.996081e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.996411e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.996811e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.997029e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.997185e-01 0.000 0 0
Keratinization R-HSA-6805567 9.997475e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.997916e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.998447e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.998485e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.998578e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.998829e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.999093e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999396e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999521e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999610e-01 0.000 1 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999641e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999675e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999678e-01 0.000 1 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999731e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999761e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999773e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999805e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999847e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999849e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999873e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999874e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999874e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999938e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999946e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999972e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999972e-01 0.000 0 0
Disease R-HSA-1643685 9.999979e-01 0.000 1 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999980e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999982e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999983e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999986e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999992e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999992e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999992e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999993e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999996e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999997e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways