TYK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
Y Sites Probabilities
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A1L429 Y10 Sugiyama GAGE12B; GAGE12C; GAGE12D; GAGE12E ___________MSWRGRsTyyWPRPRRYVQPPEMIGPMRPE
A5A3E0 Y1062 Sugiyama POTEF A26C1B GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCL_______
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
A6NDE8 Y10 Sugiyama GAGE12H ___________MSWRGRsTyyWPRPRRYVQPPEMIGPMRPE
A6NER3 Y10 Sugiyama GAGE12J ___________MSWRGRsTyyWPRPRPYVQPPEMIGPMRPE
O14910 Y133 Sugiyama LIN7A MALS1 VELI1 KTDEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLKRGD
O14950 Y156 Sugiyama MYL12B MRLC2 MYLC2B DEEVDELyREAPIDKKGNFNyIEFtRILKHGAKDKDD____
O14979 Y167 Sugiyama HNRNPDL HNRPDL JKTBP DGKMFIGGLSWDTsKKDLtEyLSRFGEVVDCtIKTDPVTGR
O15304 Y162 EPSD|PSP SIVA1 SIVA CWGCGSVACTLCGLVDCSDMyEKVLCTSCAMFET_______
O15304 Y53 EPSD|PSP SIVA1 SIVA RySQEVFEKTKRLLFLGAQAyLDHVWDEGCAVVHLPEsPKP
O43448 Y311 Sugiyama KCNAB3 KCNA3B LITSKYDGRVPDTCRASIKGyQWLKDKVQSEDGKKQQAKVM
O43707 Y212 Sugiyama ACTN4 WKDGLAFNALIHRHRPELIEyDKLRKDDPVTNLNNAFEVAE
O43852 Y187 Sugiyama CALU GDLIATKEEFtAFLHPEEyDyMKDIVVQEtMEDIDKNADGF
O43852 Y263 Sugiyama CALU KNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNKDG
O43852 Y47 Sugiyama CALU RVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQLtPE
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60664 Y95 Sugiyama PLIN3 M6PRBP1 TIP47 VsGAQPILSKLEPQIAsAsEyAHRGLDKLEENLPILQQPTE
O60739 Y30 Sugiyama EIF1B FDPFADATKGDDLLPAGTEDyIHIRIQQRNGRKtLttVQGI
O60814 Y43 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
O75347 Y75 Sugiyama TBCA EILQEsRMMIPDCQRRLEAAyLDLQRILENEKDLEEAEEyK
O75348 Y47 Sugiyama ATP6V1G1 ATP6G ATP6G1 ATP6J KRKNRRLKQAKEEAQAEIEQyRLQREKEFKAKEAAALGsRG
O75683 Y10 Sugiyama SURF6 SURF-6 ___________MASLLAKDAyLQsLAKKICSHsAPEQQART
O76087 Y10 Sugiyama GAGE7 GAGE12I GAGE7B ___________MSWRGRsTyyWPRPRRYVQPPEMIGPMRPE
O95218 Y114 Sugiyama ZRANB2 ZIS ZNF265 AKLEERtGYGGGFNERENVEyIEREEsDGEyDEFGRKKKKY
O95817 T242 Sugiyama BAG3 BIS QPsFHQAQKTHyPAQQGEyQtHQPVyHKIQGDDWEPRPLRA
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P02786 Y402 Sugiyama TFRC KEIKILNIFGVIKGFVEPDHyVVVGAQRDAWGPGAAKSGVG
P04080 Y97 Sugiyama CSTB CST6 STFB NKPLtLsNyQTNKAKHDELtyF___________________
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 Y314 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 tFDAGAGIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsK
P04406 Y320 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE_____
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05362 Y455 Sugiyama ICAM1 GtFPLPIGEsVtVtRDLEGtyLCRARSTQGEVTRKVTVNVL
P06733 S268 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 ASEFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyP
P06733 Y189 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 MILPVGAANFREAMRIGAEVyHNLKNVIKEKyGKDAtNVGD
P06733 Y270 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P06733 Y280 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 DFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDD
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07437 Y50 Sugiyama TUBB TUBB5 OK/SW-cl.56 IDPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEP
P07437 Y51 Sugiyama TUBB TUBB5 OK/SW-cl.56 DPTGtyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPG
P07711 Y311 Sugiyama CTSL CTSL1 DNNKYWLVKNsWGEEWGMGGyVKMAKDRRNHCGIAsAAsyP
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P07900 Y313 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA tKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEG
P07900 Y492 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DEMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLR
P07900 Y493 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EMVsLKDYCTRMKENQKHIyyItGETKDQVANsAFVERLRK
P07900 Y61 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA KEIFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLI
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08238 Y472 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB sELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEsKE
P08238 Y484 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVR
P08238 Y485 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB EMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRK
P08238 Y56 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEIFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDII
P08238 Y619 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB TANMERIMKAQALRDNstMGyMMAKKHLEINPDHPIVEtLR
P08708 Y84 Sugiyama RPS17 RPS17L GPVRGISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKE
P09234 Y8 Sugiyama SNRPC _____________MPKFyCDyCDtyLtHDsPsVRKTHCSGR
P0CG38 Y1062 Sugiyama POTEI GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P0CG39 Y1025 Sugiyama POTEJ GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
P0CL80 Y10 Sugiyama GAGE12F ___________MSWRGRsTyyWPRPRRYVQPPEMIGPMRPE
P0DSO3 Y10 Sugiyama GAGE4 ___________MSWRGRsTyyWPRPRRYVQPPEMIGPMRPE
P10809 Y223 Sugiyama HSPD1 HSP60 DGKtLNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAy
P10809 Y227 Sugiyama HSPD1 HSP60 LNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLs
P10809 Y243 Sugiyama HSPD1 HSP60 yIsPyFINtsKGQKCEFQDAyVLLsEKKIssIQsIVPALEI
P11142 Y134 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FYPEEVSSMVLTKMKEIAEAyLGKtVTNAVVtVPAyFNDsQ
P11142 Y41 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P11142 Y545 Sugiyama HSPA8 HSC70 HSP73 HSPA10 YKAEDEKQRDKVssKNsLEsyAFNMKATVEDEKLQGKINDE
P12277 Y125 Sugiyama CKB CKBB EHKTDLNPDNLQGGDDLDPNyVLssRVRTGRSIRGFCLPPH
P13073 Y38 Sugiyama COX4I1 COX4 SVCVRAHESVVKsEDFsLPAyMDRRDHPLPEVAHVKHLSAS
P13674 Y282 Sugiyama P4HA1 P4HA ASDDQSDQKTTPKKKGVAVDyLPERQKyEMLCRGEGIKMTP
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P13987 Y86 Sugiyama CD59 MIC11 MIN1 MIN2 MIN3 MSK21 KFEHCNFNDVtTRLRENELtyyCCKKDLCNFNEQLENGGTS
P14314 Y106 Sugiyama PRKCSH G19P1 yIPSNRVNDGVCDCCDGtDEyNsGVICENtCKEKGRKEREs
P14649 Y86 Sugiyama MYL6B MLC1SA LEEFKEAFELFDRVGDGKILysQCGDVMRALGQNPtNAEVL
P14854 Y57 Sugiyama COX6B1 COX6B FHRCQKAMTAKGGDIsVCEWyQRVYQsLCPtsWVTDWDEQR
P15328 Y80 Sugiyama FOLR1 FOLR WRKNACCSTNTSQEAHKDVsyLyRFNWNHCGEMAPACKRHF
P15880 Y248 Sugiyama RPS2 RPS4 GCtAtLGNFAKATFDAISKTysyLtPDLWKEtVFtKsPyQE
P15880 Y250 Sugiyama RPS2 RPS4 tAtLGNFAKATFDAISKTysyLtPDLWKEtVFtKsPyQEFt
P17066 Y43 Sugiyama HSPA6 HSP70B' FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P17181 Y466 SIGNOR|ELM|iPTMNet|EPSD|PSP IFNAR1 IFNAR ALFALPFVIYAAKVFLRCINyVFFPSLKPsssIDEyFSEQP
P17181 Y481 SIGNOR|ELM|iPTMNet|EPSD|PSP IFNAR1 IFNAR LRCINyVFFPSLKPsssIDEyFSEQPLKNLLLstsEEQIEK
P17676 Y139 Sugiyama CEBPB TCF5 PP9092 SDLFSDDYGGKNCKKPAEyGyVsLGRLGAAKGALHPGCFAP
P18206 Y822 Sugiyama VCL KAVAGNIsDPGLQKsFLDsGyRILGAVAKVREAFQPQEPDF
P18615 Y133 Sugiyama NELFE RD RDBP sIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEA
P18615 Y170 Sugiyama NELFE RD RDBP GEEAEGPGAGDGPPRsFDWGyEERSGAHSsAsPPRsRSRDR
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19105 Y155 Sugiyama MYL12A MLCB MRLC3 RLC DEEVDELyREAPIDKKGNFNyIEFtRILKHGAKDKDD____
P19338 Y462 Sugiyama NCL AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P20618 Y158 Sugiyama PSMB1 PSC5 IGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLLD
P22234 Y22 Sugiyama PAICS ADE2 AIRC PAIS AtAEVLNIGKKLYEGKtKEVyELLDsPGKVLLQsKDQItAG
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23396 Y34 Sugiyama RPS3 OK/SW-cl.26 DGIFKAELNEFLtRELAEDGysGVEVRVtPTRTEIIILATR
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23528 Y140 Sugiyama CFL1 CFL SKDAIKKKLtGIKHELQANCyEEVKDRCTLAEKLGGsAVIs
P24534 Y18 Sugiyama EEF1B2 EEF1B EF1B ___MGFGDLKsPAGLQVLNDyLADKSYIEGYVPsQADVAVF
P25398 Y127 Sugiyama RPS12 sCVVVKDYGKESQAKDVIEEyFKCKK_______________
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27348 Y48 Sugiyama YWHAQ AVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSIEQK
P27816 Y47 Sugiyama MAP4 AtLEAEAFDDVVGETVGKTDyIPLLDVDEKtGNsESKKKPC
P29353 Y427 Sugiyama SHC1 SHC SHCA RKQMPPPPPCPGRELFDDPsyVNVQNLDKARQAVGGAGPPN
P29597 S1063 Sugiyama TYK2 GLAKAVPEGHEyyRVREDGDsPVFWyAPECLKEYKFYYASD
P29597 S912 Sugiyama TYK2 FHKRYLKKIRDLGEGHFGKVsLyCyDPtNDGtGEMVAVKAL
P29597 T919 Sugiyama TYK2 KIRDLGEGHFGKVsLyCyDPtNDGtGEMVAVKALKADCGPQ
P29597 T923 Sugiyama TYK2 LGEGHFGKVsLyCyDPtNDGtGEMVAVKALKADCGPQHRSG
P29597 Y1054 SIGNOR|ELM|iPTMNet|EPSD|PSP|Sugiyama TYK2 DRLVKIGDFGLAKAVPEGHEyyRVREDGDsPVFWyAPECLK
P29597 Y1055 SIGNOR|ELM|iPTMNet|EPSD|PSP TYK2 RLVKIGDFGLAKAVPEGHEyyRVREDGDsPVFWyAPECLKE
P29597 Y1068 Sugiyama TYK2 VPEGHEyyRVREDGDsPVFWyAPECLKEYKFYYASDVWSFG
P29597 Y1145 Sugiyama TYK2 TELLERGERLPRPDKCPCEVyHLMKNCWETEASFRPTFENL
P29597 Y292 PSP TYK2 TERVPVCHLRLLAQAEGEPCyIRDSGVAPTDPGPESAAGPP
P29597 Y914 Sugiyama TYK2 KRYLKKIRDLGEGHFGKVsLyCyDPtNDGtGEMVAVKALKA
P29597 Y916 Sugiyama TYK2 YLKKIRDLGEGHFGKVsLyCyDPtNDGtGEMVAVKALKADC
P29597 Y955 Sugiyama TYK2 DCGPQHRSGWKQEIDILRTLyHEHIIKYKGCCEDQGEKSLQ
P29692 Y26 Sugiyama EEF1D EF1D LAHEKIWFDKFKYDDAERRFyEQMNGPVAGAsRQENGAsVI
P30086 S104 Sugiyama PEBP1 PBP PEBP WHHFLVVNMKGNDIssGtVLsDyVGsGPPKGtGLHRyVWLV
P30086 Y106 Sugiyama PEBP1 PBP PEBP HFLVVNMKGNDIssGtVLsDyVGsGPPKGtGLHRyVWLVyE
P30086 Y176 Sugiyama PEBP1 PBP PEBP KKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK_________
P30086 Y64 Sugiyama PEBP1 PBP PEBP tQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREW
P30101 Y100 Sugiyama PDIA3 ERP57 ERP60 GRP58 LAKVDCTANTNTCNKyGVsGyPtLKIFRDGEEAGAyDGPRt
P30101 Y115 Sugiyama PDIA3 ERP57 ERP60 GRP58 yGVsGyPtLKIFRDGEEAGAyDGPRtADGIVsHLKKQAGPA
P30101 Y356 Sugiyama PDIA3 ERP57 ERP60 GRP58 FVMQEEFsRDGKALERFLQDyFDGNLKRyLKsEPIPESNDG
P31943 Y266 Sugiyama HNRNPH1 HNRPH HNRPH1 yNGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGstFQst
P31946 Y50 Sugiyama YWHAB AVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P31947 Y48 Sugiyama SFN HME1 GAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsIEQK
P31948 Y354 Sugiyama STIP1 DVLKKCQQAEKILKEQERLAyINPDLALEEKNKGNECFQKG
P31948 Y41 Sugiyama STIP1 DDALQCysEAIKLDPHNHVLysNRsAAyAKKGDYQKAyEDG
P32929 Y60 Sugiyama CTH PISLSTTFKQGAPGQHsGFEysRsGNPTRNCLEKAVAALDG
P32969 Y180 Sugiyama RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9 LIQQATTVKNKDIRKFLDGIyVsEKGtVQQADE________
P33316 Y167 Sugiyama DUT PPMEKAVVKTDIQIALPsGCyGRVAPRSGLAAKHFIDVGAG
P34931 Y43 Sugiyama HSPA1L FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P37108 Y27 Sugiyama SRP14 EQFLtELTRLFQKCRTSGsVyItLKKYDGRTKPIPKKGtVE
P37802 Y192 Sugiyama TAGLN2 KIAA0120 CDABP0035 NVIGLQMGtNRGAsQAGMtGyGMPRQIL_____________
P38646 Y196 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 EtAENyLGHtAKNAVItVPAyFNDsQRQAtKDAGQIsGLNV
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P40763 Y640 EPSD|PSP STAT3 APRF TFtWVEKDISGKTQIQSVEPyTKQQLNNMSFAEIIMGYKIM
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41567 Y30 Sugiyama EIF1 SUI1 FDPFADAsKGDDLLPAGTEDyIHIRIQQRNGRKtLttVQGI
P42224 Y701 GPS6|SIGNOR|iPTMNet|EPSD|PSP STAT1 YSRPKEAPEPMELDGPKGtGyIKtELIsVsEVHPSRLQttD
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46777 Y207 Sugiyama RPL5 MSTP030 sKEFNAEVHRKHIMGQNVADyMRyLMEEDEDAyKKQFsQyI
P46778 Y30 Sugiyama RPL21 GTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQK
P47224 Y114 Sugiyama RABIF MSS4 RASGRF3 CADCEIGPIGWHCLDDKNSFyVALERVSHE___________
P47914 Y98 Sugiyama RPL29 PKEVKPKIPKGVSRKLDRLAyIAHPKLGKRARARIAKGLRL
P48741 Y43 Sugiyama HSPA7 HSP70B FQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAAL
P50990 Y30 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 GFAQMLKEGAKHFsGLEEAVyRNIQACKELAQTTRTAYGPN
P51116 Y614 Sugiyama FXR2 FMR1L2 RGNRtDGsIsGDRQPVtVADyIsRAEsQsRQRPPLERTKPs
P51452 Y138 SIGNOR DUSP3 VHR GRVLVHCREGYSRSPTLVIAyLMMRQKMDVKSALSIVRQNR
P52597 Y266 Sugiyama HNRNPF HNRPF ySGLSDGYGFTTDLFGRDLsyCLsGMyDHRYGDsEFtVQsT
P53634 Y438 Sugiyama CTSC CPPI SGMDYWIVKNsWGtGWGENGyFRIRRGtDECAIEsIAVAAt
P54652 Y42 Sugiyama HSPA2 FQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAM
P55795 Y266 Sugiyama HNRNPH2 FTP3 HNRPH2 YGGYNDGYGFGSDRFGRDLNyCFsGMsDHRyGDGGssFQst
P57053 Y43 Sugiyama H2BC12L H2BFS H2BS1 QKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
P58876 Y43 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60660 Y29 Sugiyama MYL6 TAEFKEAFQLFDRtGDGKILysQCGDVMRALGQNPtNAEVL
P60660 Y89 Sugiyama MYL6 HFLPMLQTVAKNKDQGtyEDyVEGLRVFDKEGNGtVMGAEI
P60709 Y198 Sugiyama ACTB LDLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCy
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y362 Sugiyama ACTB GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P61024 Y7 Sugiyama CKS1B CKS1 PNAS-143 PNAS-16 ______________MSHKQIyysDKyDDEEFEyRHVMLPKD
P61081 Y172 Sugiyama UBE2M UBC12 VLQNNRRLFEQNVQRSMRGGyIGstyFERCLK_________
P61081 Y177 Sugiyama UBE2M UBC12 RRLFEQNVQRSMRGGyIGstyFERCLK______________
P61247 Y256 Sugiyama RPS3A FTE1 MFTL sssGKAtGDEtGAKVERADGyEPPVQEsV____________
P61247 Y31 Sugiyama RPS3A FTE1 MFTL KGGKKGAKKKVVDPFSKKDWyDVKAPAMFNIRNIGKTLVTR
P61604 T79 Sugiyama HSPE1 EIQPVsVKVGDKVLLPEyGGtKVVLDDKDyFLFRDGDILGK
P61604 Y76 Sugiyama HSPE1 KGGEIQPVsVKVGDKVLLPEyGGtKVVLDDKDyFLFRDGDI
P61978 Y323 Sugiyama HNRNPK HNRPK RARNLPLPPPPPPRGGDLMAyDRRGRPGDRYDGMVGFSADE
P61981 Y49 Sugiyama YWHAG NVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSIEQK
P62081 Y177 Sugiyama RPS7 HLDKAQQNNVEHKVEtFsGVyKKLTGKDVNFEFPEFQL___
P62258 Y49 Sugiyama YWHAE KVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssIEQK
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62269 Y95 Sugiyama RPS18 D6S218E RQYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLK
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62277 Y18 Sugiyama RPS13 ___MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVKEQIy
P62280 Y55 Sugiyama RPS11 RYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILsG
P62312 Y72 Sugiyama LSM6 VNGQLKNKyGDAFIRGNNVLyIstQKRRM____________
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62750 Y144 Sugiyama RPL23A VNtLIRPDGEKKAYVRLAPDyDALDVANKIGII________
P62753 Y156 Sugiyama RPS6 OK/SW-cl.2 KRASRIRKLFNLsKEDDVRQyVVRKPLNKEGKKPRTKAPKI
P62807 Y43 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI QKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKAMGIM
P62826 Y146 Sugiyama RAN ARA24 OK/SW-cl.81 IKDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLAR
P62826 Y147 Sugiyama RAN ARA24 OK/SW-cl.81 KDRKVKAKsIVFHRKKNLQyyDIsAKSNyNFEKPFLWLARK
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62979 Y148 Sugiyama RPS27A UBA80 UBCEP1 AGVFMAsHFDRHyCGKCCLtyCFNKPEDK____________
P63104 Y48 Sugiyama YWHAZ sVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssIEQK
P63220 T52 Sugiyama RPS21 IQMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRL
P63220 Y53 Sugiyama RPS21 QMNVAEVDKVTGRFNGQFKtyAICGAIRRMGEsDDsILRLA
P63244 Y194 ELM|iPTMNet|EPSD|PSP RACK1 GNB2L1 HLC7 PIG21 VKVWNLANCKLKTNHIGHtGyLNTVTVSPDGSLCASGGKDG
P63261 Y198 Sugiyama ACTG1 ACTG LDLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCy
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y362 Sugiyama ACTG1 ACTG GGsILAsLstFQQMWISKQEyDEsGPsIVHRKCF_______
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68104 Y29 Sugiyama EEF1A1 EEF1A EF1A LENG7 NIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKFEKEAAEM
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P83731 Y11 Sugiyama RPL24 __________MKVELCsFsGyKIYPGHGRRYARTDGKVFQF
P84103 Y33 Sugiyama SRSF3 SFRS3 SRP20 yVGNLGNNGNKtELERAFGyyGPLRSVWVARNPPGFAFVEF
P98082 Y38 Sugiyama DAB2 DOC2 AAPKAPsKKEKKKGPEKTDEyLLARFKGDGVKYKAKLIGID
P98179 Y127 Sugiyama RBM3 RNPL GGDQGYGSGRyyDsRPGGyGyGyGRSRDYNGRNQGGYDRys
P98179 Y129 Sugiyama RBM3 RNPL DQGYGSGRyyDsRPGGyGyGyGRSRDYNGRNQGGYDRysGG
Q00839 Y257 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 QKGGDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVE
Q00839 Y260 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 GDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVEEED
Q01105 Y146 Sugiyama SET tEFEDIKsGyRIDFyFDENPyFENKVLSKEFHLNEsGDPss
Q01130 Y44 Sugiyama SRSF2 SFRS2 RtsPDtLRRVFEKYGRVGDVyIPRDRYTKESRGFAFVRFHD
Q04917 Y49 Sugiyama YWHAH YWHA1 AVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSIEQK
Q05639 Y29 Sugiyama EEF1A2 EEF1AL STN NIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKFEKEAAEM
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q13069 Y10 Sugiyama GAGE5 ___________MSWRGRsTyyWPRPRRYVQPPEVIGPMRPE
Q13070 Y10 Sugiyama GAGE6 ___________MSWRGRsTyyWPRPRRYVQPPEVIGPMRPE
Q13303 Y270 Sugiyama KCNAB2 KCNA2B KCNK2 IVSGKYDSGIPPYSRAsLKGyQWLKDKILSEEGRRQQAKLK
Q13442 T18 Sugiyama PDAP1 HASPP28 ___MPKGGRKGGHKGRARQytsPEEIDAQLQAEKQKAREEE
Q13573 Y176 Sugiyama SNW1 SKIIP SKIP SQKVAAAMPVRAADKLAPAQyIRytPsQQGVAFNsGAKQRV
Q13573 Y260 Sugiyama SNW1 SKIIP SKIP KEQQEWKIPPCISNWKNAKGytIPLDKRLAADGRGLQTVHI
Q13651 Y446 GPS6|ELM|iPTMNet|EPSD IL10RA IL10R SPPEPEVPGEEDPAAVAFQGyLRQTRCAEEKATKTGCLEEE
Q13651 Y496 GPS6|ELM|iPTMNet|EPSD IL10RA IL10R KFGRCLVDEAGLHPPALAKGyLKQDPLEMTLASSGAPTGQW
Q13765 S117 Sugiyama NACA HSD48 RKSKNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQL
Q13765 Y120 Sugiyama NACA HSD48 KNILFVITKPDVYKSPAsDtyIVFGEAKIEDLsQQAQLAAA
Q14247 Y334 Sugiyama CTTN EMS1 KDRMDKNAstFEDVtQVssAyQKTVPVEAVtsKtsNIRANF
Q14257 Y311 Sugiyama RCN2 ERC55 NPDLFLtsEAtDyGRQLHDDyFyHDEL______________
Q14257 Y313 Sugiyama RCN2 ERC55 DLFLtsEAtDyGRQLHDDyFyHDEL________________
Q14671 Y83 Sugiyama PUM1 KIAA0099 PUMH1 SPVPGSIGVAGRsQDDAMVDyFFQRQHGEQLGGGGsGGGGy
Q15293 Y278 Sugiyama RCN1 RCN LNKDGKLDKDEIRHWILPQDyDHAQAEARHLVyESDKNKDE
Q15424 Y723 Sugiyama SAFB HAP HET SAFB1 EQERRPAVRRPYDLDRRDDAyWPEAKRAALDERYHSDFNRQ
Q15427 Y16 Sugiyama SF3B4 SAP49 _____MAAGPISERNQDAtVyVGGLDEKVSEPLLWELFLQA
Q15527 Y123 Sugiyama SURF2 GRRYQRALCKYEECQKQGVEyVPACLVHRRRRREDQMDGDG
Q15555 Y268 Sugiyama MAPRE2 RP1 NEQVHsLKLALEGVEKERDFyFGKLREIELLCQEHGQENDD
Q15691 Y217 Sugiyama MAPRE1 MQQVNVLKLtVEDLEKERDFyFGKLRNIELICQENEGENDP
Q16719 S443 Sugiyama KYNU VVCDKRNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsAET
Q16719 Y448 Sugiyama KYNU RNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsAETKN___
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF6 Y32 Sugiyama HSP90AB4P KEIFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDII
Q58FF7 Y492 Sugiyama HSP90AB3P HSP90BC TANMEQIMKAQALRDNstMGyMMAKKHLEINPDHPIMETLR
Q58FF7 Y56 Sugiyama HSP90AB3P HSP90BC EEIFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDII
Q58FF8 Y260 Sugiyama HSP90AB2P HSP90BB VRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVW
Q58FF8 Y261 Sugiyama HSP90AB2P HSP90BB RYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVWK
Q58FF8 Y56 Sugiyama HSP90AB2P HSP90BB KEIFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDII
Q58FG0 Y177 Sugiyama HSP90AA5P HSP90AE GQLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQ
Q58FG0 Y178 Sugiyama HSP90AA5P HSP90AE QLEELKDSRRVMKANQKHIyyItGETKDQVANSAFVECLQK
Q5JTH9 Y1251 Sugiyama RRP12 KIAA0690 AEYKAKKAKGDVKKKGRPDPyAyIPLNRSKLNRRKKMKLQG
Q5JTH9 Y1253 Sugiyama RRP12 KIAA0690 YKAKKAKGDVKKKGRPDPyAyIPLNRSKLNRRKKMKLQGQF
Q5QNW6 Y43 Sugiyama H2BC18 HIST2H2BF QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q5VTE0 Y29 Sugiyama EEF1A1P5 EEF1AL3 NIVVIGHVDsGKstttGHLIyKCGGIDKRTIEKFEKEAAEM
Q6FI81 Y278 Sugiyama CIAPIN1 CUA001 PRO0915 EKEKSREQMSSQPKsACGNCyLGDAFRCAsCPyLGMPAFKP
Q6S8J3 Y1062 Sugiyama POTEE A26C1A POTE2 GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6UN15 Y453 Sugiyama FIP1L1 FIP1 RHE HLPGSAPsWPSLVDTSKQWDyyARREKDRDRERDRDRERDR
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q86V81 Y250 Sugiyama ALYREF ALY BEF THOC4 AGRNSKQQLsAEELDAQLDAyNARMDts_____________
Q8N6H7 Y278 Sugiyama ARFGAP2 ZNF289 Nbla10535 QAADAKKQAEESMVASMRLAyQELQIDRKKEEKKLQNLEGK
Q8ND56 Y455 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A RGFRGGFRGGRGGREFADFEyRKTTAFGP____________
Q8NI22 Y135 Sugiyama MCFD2 SDNSF DELINIIDGVLRDDDKNNDGyIDyAEFAKSLQ_________
Q8TDD1 Y681 Sugiyama DDX54 GPNRGAKRRREEARQRDQEFyIPyRPKDFDSERGLsIsGEG
Q92882 Y207 Sugiyama OSTF1 sLLKKKQGTDAVRtLsNAEDyLDDEDsD_____________
Q93079 Y43 Sugiyama H2BC9 H2BFJ HIST1H2BH QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q96CT7 Y38 Sugiyama CCDC124 RRAEAKAAADAKKQKELEDAyWKDDDKHVMRKEQRKEEKEK
Q99470 Y69 Sugiyama SDF2 GSGSGQQSVTGVTSVDDSNSyWRIRGKSATVCERGTPIKCG
Q99877 Y43 Sugiyama H2BC15 H2BFD HIST1H2BN QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q99879 Y43 Sugiyama H2BC14 H2BFE HIST1H2BM QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q99880 Y43 Sugiyama H2BC13 H2BFC HIST1H2BL QKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKAMGIM
Q99961 Y57 Sugiyama SH3GL1 CNSA1 SH3D2B EKKVDVTSKAVTEVLARTIEyLQPNPAsRAKLTMLNTVSKI
Q99962 Y57 Sugiyama SH3GL2 CNSA2 SH3D2A ERKVDVTSRAVMEIMTKTIEyLQPNPAsRAKLSMINTMsKI
Q9BQE3 Y432 Sugiyama TUBA1C TUBA6 GMEEGEFSEAREDMAALEKDyEEVGADsADGEDEGEEy___
Q9BRL6 Y44 Sugiyama SRSF8 SFRS2B SRP46 RtsPDsLRRVFEKYGRVGDVyIPREPHTKAPRGFAFVRFHD
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9BYX7 Y362 Sugiyama POTEKP ACTBL3 FKSG30 GGSILASLSTFQQMWISKQEyDEsGPsIVHRKCF_______
Q9HAP6 Y118 Sugiyama LIN7B MALS2 VELI2 UNQ3116/PRO10200 KTDEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLKRGD
Q9HCN8 Y81 Sugiyama SDF2L1 UNQ1941/PRO4424 GSGSGQQSVtGVEAsDDANSyWRIRGGSEGGCPRGSPVRCG
Q9HDC5 Y417 Sugiyama JPH1 JP1 AARQECDIARAVARELsPDFyQPGPDyVKQRFQEGVDAKEN
Q9HDC5 Y423 Sugiyama JPH1 JP1 DIARAVARELsPDFyQPGPDyVKQRFQEGVDAKENPEEKVP
Q9NP61 Y432 Sugiyama ARFGAP3 ARFGAP1 ENTDEAQKKFGNVKAIssDMyFGRQsQADYETRARLERLsA
Q9NRX4 Y116 Sugiyama PHPT1 PHP14 CGI-202 HSPC141 AyGPAQHAISTEKIKAKyPDyEVtWANDGy___________
Q9NUP9 Y118 Sugiyama LIN7C MALS3 VELI3 KTEEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLKRGD
Q9NVS9 Y157 Sugiyama PNPO NRQVRVEGPVKKLPEEEAECyFHSRPKssQIGAVVSHQSSV
Q9NVS9 Y256 Sugiyama PNPO LPtGDsPLGPMTHRGEEDWLyERLAP_______________
Q9UBR2 Y76 Sugiyama CTSZ YLSPADLPKSWDWRNVDGVNyAsItRNQHIPQYCGSCWAHA
Q9UI15 Y192 Sugiyama TAGLN3 NP25 NVIGLQMGSNKGAsQAGMtGyGMPRQIM_____________
Q9UII2 Y58 Sugiyama ATP5IF1 ATPI ATPIF1 GsIREAGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEI
Q9UMX5 Y65 Sugiyama NENF CIR2 SPUF RLFtEEELARYGGEEEDQPIyLAVKGVVFDVtSGKEFYGRG
Q9UN86 Y19 Sugiyama G3BP2 KIAA0660 __MVMEKPsPLLVGREFVRQyytLLNKAPEYLHRFYGRNSS
Q9Y2B0 Y71 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEICDRMKE
Q9Y2W1 T230 Sugiyama THRAP3 BCLAF2 TRAP150 tsQDTKAsEssKPWPDAtyGtGsAsRAsAVsELsPRERsPA
Q9Y2W1 Y228 Sugiyama THRAP3 BCLAF2 TRAP150 GGtsQDTKAsEssKPWPDAtyGtGsAsRAsAVsELsPRERs
Q9Y3U8 Y53 Sugiyama RPL36 LTKHTKFVRDMIREVCGFAPyERRAMELLKVSKDKRALKFI
Q9Y5Y0 Y22 Sugiyama FLVCR1 FLVCR ARPDDEEGAAVAPGHPLAKGyLPLPRGAPVGKESVELQNGP
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.509903e-14 13.821 1 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.376910e-11 10.471 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.125051e-07 6.505 1 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 7.043381e-07 6.152 1 1
Signaling by ALK in cancer R-HSA-9700206 7.043381e-07 6.152 1 0
Cytokine Signaling in Immune system R-HSA-1280215 1.483830e-06 5.829 1 0
MAPK family signaling cascades R-HSA-5683057 2.156452e-06 5.666 1 0
FGFR1 mutant receptor activation R-HSA-1839124 4.406486e-06 5.356 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.846101e-06 5.233 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.223175e-06 5.206 0 0
Signaling by ERBB2 R-HSA-1227986 9.436834e-06 5.025 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.396351e-05 4.855 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 1.036062e-05 4.985 0 0
IGF1R signaling cascade R-HSA-2428924 1.359274e-05 4.867 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.483950e-05 4.829 0 0
Signaling by KIT in disease R-HSA-9669938 1.396351e-05 4.855 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.346777e-05 4.871 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.589260e-05 4.799 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 1.753452e-05 4.756 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.799674e-05 4.745 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.792272e-05 4.554 0 0
Interferon Signaling R-HSA-913531 2.933790e-05 4.533 1 0
Co-stimulation by CD28 R-HSA-389356 3.332722e-05 4.477 0 0
Signaling by FGFR in disease R-HSA-1226099 3.093809e-05 4.510 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.515936e-05 4.454 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.530292e-05 4.452 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.015582e-05 4.396 1 1
PI3K Cascade R-HSA-109704 4.043114e-05 4.393 0 0
Regulation of KIT signaling R-HSA-1433559 4.521850e-05 4.345 0 0
Signal Transduction R-HSA-162582 4.452689e-05 4.351 1 0
IRS-mediated signalling R-HSA-112399 7.539035e-05 4.123 0 0
FLT3 signaling in disease R-HSA-9682385 1.050305e-04 3.979 0 0
Insulin receptor signalling cascade R-HSA-74751 1.310830e-04 3.882 0 0
Signaling by PTK6 R-HSA-8848021 1.215779e-04 3.915 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.215779e-04 3.915 0 0
Nef and signal transduction R-HSA-164944 1.309675e-04 3.883 0 0
Regulation of signaling by CBL R-HSA-912631 1.360557e-04 3.866 0 0
Signaling by VEGF R-HSA-194138 1.374058e-04 3.862 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.588827e-04 3.799 0 0
SOS-mediated signalling R-HSA-112412 1.782680e-04 3.749 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 2.126495e-04 3.672 1 1
Signaling by SCF-KIT R-HSA-1433557 2.303772e-04 3.638 0 0
Growth hormone receptor signaling R-HSA-982772 2.784189e-04 3.555 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.162584e-04 3.500 0 0
PI3K/AKT activation R-HSA-198203 3.826704e-04 3.417 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.027736e-04 3.395 0 0
Signal attenuation R-HSA-74749 3.826704e-04 3.417 0 0
Signaling by Leptin R-HSA-2586552 3.826704e-04 3.417 0 0
Interferon alpha/beta signaling R-HSA-909733 4.886947e-04 3.311 1 1
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.886947e-04 3.311 0 0
PECAM1 interactions R-HSA-210990 4.742667e-04 3.324 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.624680e-04 3.250 0 0
Signaling by Interleukins R-HSA-449147 5.334565e-04 3.273 1 0
Immune System R-HSA-168256 5.620137e-04 3.250 1 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.244429e-04 3.205 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.244429e-04 3.205 0 0
Nervous system development R-HSA-9675108 7.145735e-04 3.146 0 0
Signaling by Insulin receptor R-HSA-74752 8.181542e-04 3.087 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.393041e-04 3.076 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.140624e-03 2.943 0 0
Erythropoietin activates RAS R-HSA-9027284 1.140624e-03 2.943 0 0
Axon guidance R-HSA-422475 1.061257e-03 2.974 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.337704e-03 2.874 0 0
TRKA activation by NGF R-HSA-187042 1.337704e-03 2.874 0 0
Signalling to STAT3 R-HSA-198745 1.337704e-03 2.874 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.320156e-03 2.879 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.241303e-03 2.906 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 1.516521e-03 2.819 0 0
Signaling by ALK R-HSA-201556 1.534434e-03 2.814 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.730276e-03 2.762 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.961957e-03 2.707 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.961957e-03 2.707 0 0
Signaling by NTRKs R-HSA-166520 2.068054e-03 2.684 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.913003e-03 2.718 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.008925e-03 2.697 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.073399e-03 2.683 0 0
Other interleukin signaling R-HSA-449836 2.212075e-03 2.655 1 1
Hemostasis R-HSA-109582 2.279582e-03 2.642 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.386527e-03 2.622 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.516804e-03 2.599 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.554661e-03 2.593 0 0
IRS activation R-HSA-74713 2.585860e-03 2.587 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.107559e-03 2.508 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.077855e-03 2.512 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 3.406417e-03 2.468 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.406417e-03 2.468 0 0
Interleukin-20 family signaling R-HSA-8854691 3.755660e-03 2.425 1 1
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.755660e-03 2.425 0 0
Erythropoietin activates STAT5 R-HSA-9027283 4.215923e-03 2.375 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 4.125973e-03 2.384 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.125973e-03 2.384 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.371928e-03 2.359 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 4.517723e-03 2.345 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.517723e-03 2.345 0 0
Interleukin-7 signaling R-HSA-1266695 4.517723e-03 2.345 0 0
Signaling by FGFR1 R-HSA-5654736 4.969045e-03 2.304 0 0
Disease R-HSA-1643685 5.011986e-03 2.300 1 0
Activation of TRKA receptors R-HSA-187015 5.169051e-03 2.287 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.366922e-03 2.270 0 0
Signaling by Erythropoietin R-HSA-9006335 6.305847e-03 2.200 0 0
Interleukin-23 signaling R-HSA-9020933 6.211578e-03 2.207 1 1
Signaling by FGFR R-HSA-190236 6.313646e-03 2.200 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 6.809688e-03 2.167 0 0
Interleukin-37 signaling R-HSA-9008059 6.809688e-03 2.167 0 0
Downstream signal transduction R-HSA-186763 7.336806e-03 2.134 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.336806e-03 2.134 1 1
ALK mutants bind TKIs R-HSA-9700645 7.341542e-03 2.134 0 0
G0 and Early G1 R-HSA-1538133 7.887448e-03 2.103 0 0
Integrin signaling R-HSA-354192 8.461846e-03 2.073 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 8.557015e-03 2.068 0 0
Interleukin-27 signaling R-HSA-9020956 8.557015e-03 2.068 1 1
EGFR Transactivation by Gastrin R-HSA-2179392 8.557015e-03 2.068 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.557015e-03 2.068 1 1
Downstream signaling of activated FGFR1 R-HSA-5654687 1.032966e-02 1.986 0 0
Signalling to ERKs R-HSA-187687 1.032966e-02 1.986 0 0
GPVI-mediated activation cascade R-HSA-114604 1.100110e-02 1.959 0 0
G1/S-Specific Transcription R-HSA-69205 1.100110e-02 1.959 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 1.123692e-02 1.949 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.169723e-02 1.932 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.269764e-02 1.896 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.269764e-02 1.896 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.269764e-02 1.896 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.423646e-02 1.847 0 0
Interleukin-6 signaling R-HSA-1059683 1.423646e-02 1.847 1 1
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.269764e-02 1.896 0 0
Interleukin-15 signaling R-HSA-8983432 1.269764e-02 1.896 0 0
Signaling by LTK R-HSA-9842663 1.269764e-02 1.896 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.393515e-02 1.856 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.393515e-02 1.856 0 0
Interleukin-2 family signaling R-HSA-451927 1.393515e-02 1.856 0 0
Interleukin-35 Signalling R-HSA-8984722 1.269764e-02 1.896 1 1
Platelet Adhesion to exposed collagen R-HSA-75892 1.423646e-02 1.847 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 1.241820e-02 1.906 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.357178e-02 1.867 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.464238e-02 1.834 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 1.555287e-02 1.808 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.585158e-02 1.800 0 0
Malate-aspartate shuttle R-HSA-9856872 1.585158e-02 1.800 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.727908e-02 1.762 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.754127e-02 1.756 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.754127e-02 1.756 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 1.754127e-02 1.756 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 1.754127e-02 1.756 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.754127e-02 1.756 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.754127e-02 1.756 0 0
DAP12 interactions R-HSA-2172127 1.816986e-02 1.741 0 0
Netrin-1 signaling R-HSA-373752 1.816986e-02 1.741 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.930378e-02 1.714 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.113743e-02 1.675 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 2.304054e-02 1.638 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.004216e-02 1.698 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.304054e-02 1.638 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.304054e-02 1.638 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.930378e-02 1.714 0 0
Prolonged ERK activation events R-HSA-169893 1.930378e-02 1.714 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 2.101671e-02 1.677 0 0
Inhibition of PKR R-HSA-169131 2.089402e-02 1.680 0 0
Interleukin-12 family signaling R-HSA-447115 1.945227e-02 1.711 1 0
Uptake and function of anthrax toxins R-HSA-5210891 2.304054e-02 1.638 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 2.113743e-02 1.675 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.113743e-02 1.675 0 0
EPH-Ephrin signaling R-HSA-2682334 2.363162e-02 1.627 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 2.437703e-02 1.613 0 0
GAB1 signalosome R-HSA-180292 2.501148e-02 1.602 0 0
FGFR1 ligand binding and activation R-HSA-190242 2.501148e-02 1.602 0 0
mRNA 3'-end processing R-HSA-72187 2.627391e-02 1.580 0 0
Parasite infection R-HSA-9664407 2.630159e-02 1.580 0 0
Leishmania phagocytosis R-HSA-9664417 2.630159e-02 1.580 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 2.630159e-02 1.580 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.704862e-02 1.568 0 0
Cell-Cell communication R-HSA-1500931 2.714310e-02 1.566 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 2.750027e-02 1.561 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.812341e-02 1.551 0 0
Translation initiation complex formation R-HSA-72649 2.855593e-02 1.544 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.117770e-02 1.506 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.117770e-02 1.506 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.117770e-02 1.506 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.582782e-02 1.446 1 1
Ribosomal scanning and start codon recognition R-HSA-72702 3.093987e-02 1.509 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.131519e-02 1.504 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.131519e-02 1.504 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.342528e-02 1.476 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.093987e-02 1.509 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.354151e-02 1.474 0 0
Nephrin family interactions R-HSA-373753 2.915038e-02 1.535 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.117770e-02 1.506 0 0
Signalling to RAS R-HSA-167044 3.131519e-02 1.504 0 0
Notch-HLH transcription pathway R-HSA-350054 3.582782e-02 1.446 0 0
NCAM signaling for neurite out-growth R-HSA-375165 3.869799e-02 1.412 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 3.582782e-02 1.446 1 0
RNA Polymerase II Transcription Termination R-HSA-73856 3.734230e-02 1.428 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.869799e-02 1.412 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.354151e-02 1.474 0 0
Signal transduction by L1 R-HSA-445144 2.915038e-02 1.535 0 0
Signaling by NOTCH3 R-HSA-9012852 2.973518e-02 1.527 0 0
Potential therapeutics for SARS R-HSA-9679191 3.371200e-02 1.472 1 1
Signaling by PDGF R-HSA-186797 3.869799e-02 1.412 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.443476e-02 1.463 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 3.093987e-02 1.509 0 0
Semaphorin interactions R-HSA-373755 4.007852e-02 1.397 0 0
Deadenylation of mRNA R-HSA-429947 4.057451e-02 1.392 0 0
Interleukin-6 family signaling R-HSA-6783589 4.057451e-02 1.392 1 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.057451e-02 1.392 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.135400e-02 1.383 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.135400e-02 1.383 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.135400e-02 1.383 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.135400e-02 1.383 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) R-HSA-5619049 4.135400e-02 1.383 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.135400e-02 1.383 0 0
Defective ADA disrupts (deoxy)adenosine deamination R-HSA-9734735 4.135400e-02 1.383 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.135400e-02 1.383 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.135400e-02 1.383 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.135400e-02 1.383 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.135400e-02 1.383 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.135400e-02 1.383 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 4.135400e-02 1.383 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.135400e-02 1.383 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 4.135400e-02 1.383 0 0
Regulation of TP53 Activity R-HSA-5633007 4.147345e-02 1.382 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.548670e-02 1.342 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.554362e-02 1.342 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.554362e-02 1.342 0 0
MET activates STAT3 R-HSA-8875791 5.142402e-02 1.289 0 0
PLC-gamma1 signalling R-HSA-167021 5.142402e-02 1.289 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 5.142402e-02 1.289 0 0
MET activates PTPN11 R-HSA-8865999 5.142402e-02 1.289 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 6.138889e-02 1.212 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 6.138889e-02 1.212 0 0
Defective CP causes aceruloplasminemia (ACERULOP) R-HSA-5619060 6.138889e-02 1.212 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 6.138889e-02 1.212 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 7.124968e-02 1.147 0 0
NTRK2 activates RAC1 R-HSA-9032759 7.124968e-02 1.147 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 7.124968e-02 1.147 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.338983e-02 1.273 0 0
DAP12 signaling R-HSA-2424491 5.610450e-02 1.251 0 0
PKR-mediated signaling R-HSA-9833482 6.721824e-02 1.173 0 0
EGFR downregulation R-HSA-182971 5.886660e-02 1.230 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.452802e-02 1.190 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.167486e-02 1.210 0 0
PTK6 Activates STAT3 R-HSA-8849474 7.124968e-02 1.147 0 0
Activation of AKT2 R-HSA-165158 7.124968e-02 1.147 0 0
Interleukin-10 signaling R-HSA-6783783 6.367787e-02 1.196 1 1
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.810805e-02 1.318 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 5.142402e-02 1.289 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 5.522252e-02 1.258 0 0
Signaling by FGFR2 R-HSA-5654738 6.721824e-02 1.173 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.452802e-02 1.190 0 0
Signaling by BMP R-HSA-201451 4.810805e-02 1.318 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.072391e-02 1.295 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.338983e-02 1.273 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.036407e-02 1.153 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.810805e-02 1.318 0 0
Aspartate and asparagine metabolism R-HSA-8963693 5.886660e-02 1.230 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 6.138889e-02 1.212 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 6.138889e-02 1.212 0 0
Transmission across Electrical Synapses R-HSA-112307 6.138889e-02 1.212 0 0
NrCAM interactions R-HSA-447038 7.124968e-02 1.147 0 0
Reelin signalling pathway R-HSA-8866376 7.124968e-02 1.147 0 0
Co-inhibition by BTLA R-HSA-9927353 7.124968e-02 1.147 0 0
Effects of PIP2 hydrolysis R-HSA-114508 6.742483e-02 1.171 0 0
Interleukin-12 signaling R-HSA-9020591 6.022719e-02 1.220 1 1
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.084679e-02 1.150 0 0
L1CAM interactions R-HSA-373760 4.994250e-02 1.302 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 7.124968e-02 1.147 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.597492e-02 1.252 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.853594e-02 1.233 0 0
Signaling by ERBB4 R-HSA-1236394 5.686766e-02 1.245 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.452802e-02 1.190 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.452802e-02 1.190 0 0
RET signaling R-HSA-8853659 7.636510e-02 1.117 0 0
Glycosphingolipid transport R-HSA-9845576 7.636510e-02 1.117 0 0
RUNX2 regulates bone development R-HSA-8941326 7.636510e-02 1.117 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.636510e-02 1.117 0 0
mRNA Splicing - Major Pathway R-HSA-72163 7.654870e-02 1.116 0 0
NGF-independant TRKA activation R-HSA-187024 8.100748e-02 1.091 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 8.100748e-02 1.091 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.100748e-02 1.091 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 8.100748e-02 1.091 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 8.100748e-02 1.091 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 8.100748e-02 1.091 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 9.066336e-02 1.043 0 0
STAT5 Activation R-HSA-9645135 9.066336e-02 1.043 0 0
G2/M DNA replication checkpoint R-HSA-69478 9.066336e-02 1.043 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 9.066336e-02 1.043 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 1.096736e-01 0.960 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 1.096736e-01 0.960 0 0
FGFR1b ligand binding and activation R-HSA-190370 1.096736e-01 0.960 0 0
MET receptor recycling R-HSA-8875656 1.096736e-01 0.960 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.096736e-01 0.960 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 1.190300e-01 0.924 0 0
ARMS-mediated activation R-HSA-170984 1.190300e-01 0.924 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.282887e-01 0.892 0 0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 1.282887e-01 0.892 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.282887e-01 0.892 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.374506e-01 0.862 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.374506e-01 0.862 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.374506e-01 0.862 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.465168e-01 0.834 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.554882e-01 0.808 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.554882e-01 0.808 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.554882e-01 0.808 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.554882e-01 0.808 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.554882e-01 0.808 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.618330e-01 0.791 0 0
mRNA Splicing R-HSA-72172 9.009716e-02 1.045 0 0
Signaling by EGFR R-HSA-177929 1.471637e-01 0.832 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.465168e-01 0.834 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.002184e-01 0.999 0 0
Regulation of CDH11 function R-HSA-9762292 1.282887e-01 0.892 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.374506e-01 0.862 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.370930e-01 0.863 0 0
Signaling by MST1 R-HSA-8852405 8.100748e-02 1.091 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.859025e-02 1.006 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.592659e-01 0.798 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.592659e-01 0.798 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.100748e-02 1.091 0 0
Phosphorylation of Emi1 R-HSA-176417 8.100748e-02 1.091 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 8.100748e-02 1.091 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.374506e-01 0.862 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.374506e-01 0.862 0 0
Signaling by APC mutants R-HSA-4839744 1.374506e-01 0.862 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.465168e-01 0.834 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.465168e-01 0.834 0 0
Signaling by AXIN mutants R-HSA-4839735 1.465168e-01 0.834 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.554882e-01 0.808 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.882500e-02 1.051 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.754632e-02 1.058 0 0
Regulation of CDH1 Function R-HSA-9764561 1.508049e-01 0.822 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.071989e-01 0.970 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 8.100748e-02 1.091 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.002184e-01 0.999 0 0
Interleukin-21 signaling R-HSA-9020958 1.190300e-01 0.924 0 0
MET activates RAS signaling R-HSA-8851805 1.554882e-01 0.808 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 1.554882e-01 0.808 0 0
HDACs deacetylate histones R-HSA-3214815 1.435412e-01 0.843 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.581403e-01 0.801 0 0
Signaling by FGFR4 R-HSA-5654743 1.018366e-01 0.992 0 0
Interleukin-9 signaling R-HSA-8985947 1.096736e-01 0.960 0 0
Signaling by FGFR3 R-HSA-5654741 1.085285e-01 0.964 0 0
Signaling by TGFB family members R-HSA-9006936 1.206985e-01 0.918 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 8.100748e-02 1.091 0 0
VLDL clearance R-HSA-8964046 1.002184e-01 0.999 0 0
Nucleotide salvage defects R-HSA-9734207 1.096736e-01 0.960 0 0
MAPK1 (ERK2) activation R-HSA-112411 1.190300e-01 0.924 1 1
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 1.465168e-01 0.834 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.346992e-01 0.871 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.346992e-01 0.871 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.171608e-01 0.931 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 9.066336e-02 1.043 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.554882e-01 0.808 0 0
Repression of WNT target genes R-HSA-4641265 1.554882e-01 0.808 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 9.202885e-02 1.036 0 0
FLT3 Signaling R-HSA-9607240 9.202885e-02 1.036 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.202885e-02 1.036 0 0
VEGF ligand-receptor interactions R-HSA-194313 8.100748e-02 1.091 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 9.066336e-02 1.043 0 0
RSK activation R-HSA-444257 1.096736e-01 0.960 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.190300e-01 0.924 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.282887e-01 0.892 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.465168e-01 0.834 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 1.554882e-01 0.808 0 0
Signaling by FGFR2 in disease R-HSA-5655253 1.257378e-01 0.901 0 0
Kinesins R-HSA-983189 1.618330e-01 0.791 0 0
Respiratory electron transport R-HSA-611105 1.564770e-01 0.806 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 8.100748e-02 1.091 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 8.100748e-02 1.091 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 8.100748e-02 1.091 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 1.096736e-01 0.960 0 0
Disorders of Nervous System Development R-HSA-9697154 1.554882e-01 0.808 0 0
Pervasive developmental disorders R-HSA-9005895 1.554882e-01 0.808 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.554882e-01 0.808 0 0
Degradation of CDH1 R-HSA-9766229 1.222448e-01 0.913 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.618330e-01 0.791 0 0
Adaptive Immune System R-HSA-1280218 1.584809e-01 0.800 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.526610e-02 1.021 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.190300e-01 0.924 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 9.853571e-02 1.006 0 0
FCGR activation R-HSA-2029481 9.646913e-02 1.016 0 0
Adherens junctions interactions R-HSA-418990 1.090121e-01 0.963 0 0
Developmental Biology R-HSA-1266738 9.326968e-02 1.030 0 0
Cell-cell junction organization R-HSA-421270 1.603859e-01 0.795 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 9.202885e-02 1.036 0 0
Cell junction organization R-HSA-446728 9.742778e-02 1.011 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.190300e-01 0.924 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.229573e-01 0.910 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 9.693803e-02 1.014 0 0
FOXO-mediated transcription R-HSA-9614085 1.116163e-01 0.952 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 1.618330e-01 0.791 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.466998e-01 0.834 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.466998e-01 0.834 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.374982e-01 0.862 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.327940e-01 0.877 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 1.428584e-01 0.845 0 0
Dectin-2 family R-HSA-5621480 1.508049e-01 0.822 0 0
RSV-host interactions R-HSA-9833110 1.252745e-01 0.902 1 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.565560e-02 1.067 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.222448e-01 0.913 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.618330e-01 0.791 0 0
tRNA Aminoacylation R-HSA-379724 1.618330e-01 0.791 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.618330e-01 0.791 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.618330e-01 0.791 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.618330e-01 0.791 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.618330e-01 0.791 0 0
Cellular responses to stimuli R-HSA-8953897 1.106256e-01 0.956 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.051679e-01 0.978 0 0
Signaling by NOTCH R-HSA-157118 1.422737e-01 0.847 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.442100e-01 0.841 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.147446e-02 1.089 1 0
Cellular response to chemical stress R-HSA-9711123 8.621388e-02 1.064 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.618330e-01 0.791 0 0
FGFR1c ligand binding and activation R-HSA-190373 1.643659e-01 0.784 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 1.643659e-01 0.784 1 1
Processing of SMDT1 R-HSA-8949664 1.643659e-01 0.784 0 0
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 1.643659e-01 0.784 0 0
Frs2-mediated activation R-HSA-170968 1.643659e-01 0.784 0 0
Acetylcholine binding and downstream events R-HSA-181431 1.643659e-01 0.784 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.643659e-01 0.784 0 0
Diseases of nucleotide metabolism R-HSA-9735804 1.643659e-01 0.784 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.643659e-01 0.784 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.668893e-01 0.778 0 0
Cell Cycle, Mitotic R-HSA-69278 1.700435e-01 0.769 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.720306e-01 0.764 0 0
Complex I biogenesis R-HSA-6799198 1.730020e-01 0.762 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.731508e-01 0.762 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.731508e-01 0.762 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.731508e-01 0.762 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 1.731508e-01 0.762 0 0
Signal regulatory protein family interactions R-HSA-391160 1.731508e-01 0.762 0 0
CD22 mediated BCR regulation R-HSA-5690714 1.767530e-01 0.753 0 0
Host Interactions of HIV factors R-HSA-162909 1.798263e-01 0.745 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.805168e-01 0.743 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.818439e-01 0.740 0 0
DCC mediated attractive signaling R-HSA-418885 1.818439e-01 0.740 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.818439e-01 0.740 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.818439e-01 0.740 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.818439e-01 0.740 0 0
Signaling by Activin R-HSA-1502540 1.818439e-01 0.740 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 1.818439e-01 0.740 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.818439e-01 0.740 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.840704e-01 0.735 0 0
G1/S Transition R-HSA-69206 1.850766e-01 0.733 0 0
Mitotic Prometaphase R-HSA-68877 1.871761e-01 0.728 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 1.877169e-01 0.726 0 0
Platelet degranulation R-HSA-114608 1.903671e-01 0.720 0 0
Phosphorylation of the APC/C R-HSA-176412 1.904462e-01 0.720 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.935390e-01 0.713 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.989585e-01 0.701 0 0
Disorders of Developmental Biology R-HSA-9675151 1.989585e-01 0.701 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 1.989585e-01 0.701 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.995045e-01 0.700 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.995045e-01 0.700 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.995045e-01 0.700 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.033314e-01 0.692 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.033314e-01 0.692 0 0
Adipogenesis R-HSA-9843745 2.037578e-01 0.691 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.071666e-01 0.684 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.073818e-01 0.683 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.073818e-01 0.683 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.073818e-01 0.683 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.091750e-01 0.679 0 0
Cellular responses to stress R-HSA-2262752 2.094770e-01 0.679 0 0
Leishmania infection R-HSA-9658195 2.140355e-01 0.670 0 0
Parasitic Infection Pathways R-HSA-9824443 2.140355e-01 0.670 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.148595e-01 0.668 0 0
Ephrin signaling R-HSA-3928664 2.157171e-01 0.666 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.157171e-01 0.666 0 0
Tie2 Signaling R-HSA-210993 2.157171e-01 0.666 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.157171e-01 0.666 0 0
Platelet sensitization by LDL R-HSA-432142 2.157171e-01 0.666 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 2.225789e-01 0.653 0 0
Signaling by NOTCH1 R-HSA-1980143 2.225789e-01 0.653 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 2.239652e-01 0.650 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.239652e-01 0.650 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.239652e-01 0.650 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.239652e-01 0.650 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.239652e-01 0.650 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.239652e-01 0.650 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.239652e-01 0.650 0 0
Methionine salvage pathway R-HSA-1237112 2.239652e-01 0.650 0 0
The NLRP3 inflammasome R-HSA-844456 2.239652e-01 0.650 0 0
PTEN Regulation R-HSA-6807070 2.283765e-01 0.641 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.283765e-01 0.641 0 0
RNA Polymerase I Transcription R-HSA-73864 2.303202e-01 0.638 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 2.321271e-01 0.634 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 2.321271e-01 0.634 0 0
Formation of definitive endoderm R-HSA-9823730 2.321271e-01 0.634 0 0
Negative regulation of MET activity R-HSA-6807004 2.321271e-01 0.634 0 0
Signaling by NODAL R-HSA-1181150 2.321271e-01 0.634 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.321271e-01 0.634 0 0
Viral Infection Pathways R-HSA-9824446 2.323394e-01 0.634 1 0
Signaling by MET R-HSA-6806834 2.380791e-01 0.623 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.380791e-01 0.623 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.394966e-01 0.621 1 1
SHC-mediated cascade:FGFR3 R-HSA-5654704 2.402037e-01 0.619 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 2.402037e-01 0.619 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.422913e-01 0.616 0 0
Cell Cycle R-HSA-1640170 2.428109e-01 0.615 0 0
FCERI mediated NF-kB activation R-HSA-2871837 2.450914e-01 0.611 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.481957e-01 0.605 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.481957e-01 0.605 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 2.481957e-01 0.605 0 0
Mitochondrial calcium ion transport R-HSA-8949215 2.481957e-01 0.605 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.481957e-01 0.605 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.481957e-01 0.605 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 2.481957e-01 0.605 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.481957e-01 0.605 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.481957e-01 0.605 0 0
Ribavirin ADME R-HSA-9755088 2.481957e-01 0.605 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.536338e-01 0.596 0 0
FGFR2 alternative splicing R-HSA-6803529 2.561043e-01 0.592 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 2.561043e-01 0.592 0 0
LDL clearance R-HSA-8964038 2.561043e-01 0.592 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.614219e-01 0.583 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.614219e-01 0.583 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.639301e-01 0.579 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.639301e-01 0.579 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.639301e-01 0.579 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 2.639301e-01 0.579 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.639301e-01 0.579 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.639301e-01 0.579 0 0
Syndecan interactions R-HSA-3000170 2.639301e-01 0.579 0 0
SARS-CoV Infections R-HSA-9679506 2.648533e-01 0.577 1 0
HIV Infection R-HSA-162906 2.649822e-01 0.577 0 0
Sulfur amino acid metabolism R-HSA-1614635 2.653170e-01 0.576 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.653170e-01 0.576 0 0
Infectious disease R-HSA-5663205 2.661737e-01 0.575 1 0
SARS-CoV-2-host interactions R-HSA-9705683 2.672978e-01 0.573 1 0
Interleukin-1 family signaling R-HSA-446652 2.676640e-01 0.572 0 0
Post NMDA receptor activation events R-HSA-438064 2.692122e-01 0.570 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 2.793370e-01 0.554 0 0
Long-term potentiation R-HSA-9620244 2.793370e-01 0.554 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.793370e-01 0.554 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 2.793370e-01 0.554 0 0
TGFBR3 expression R-HSA-9839394 2.793370e-01 0.554 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.847858e-01 0.545 0 0
TRP channels R-HSA-3295583 2.869198e-01 0.542 0 0
Urea cycle R-HSA-70635 2.869198e-01 0.542 0 0
ESR-mediated signaling R-HSA-8939211 2.882943e-01 0.540 0 0
IRE1alpha activates chaperones R-HSA-381070 2.886754e-01 0.540 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.944233e-01 0.531 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.944233e-01 0.531 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 2.944233e-01 0.531 0 0
Cristae formation R-HSA-8949613 2.944233e-01 0.531 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.944233e-01 0.531 0 0
Signaling by FGFR3 in disease R-HSA-5655332 2.944233e-01 0.531 0 0
Metabolism of RNA R-HSA-8953854 2.951824e-01 0.530 0 0
Mitochondrial protein degradation R-HSA-9837999 3.003287e-01 0.522 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.018483e-01 0.520 0 0
HIV elongation arrest and recovery R-HSA-167287 3.018483e-01 0.520 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.018483e-01 0.520 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.018483e-01 0.520 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.018483e-01 0.520 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 3.018483e-01 0.520 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.018483e-01 0.520 0 0
Inflammasomes R-HSA-622312 3.018483e-01 0.520 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.091956e-01 0.510 0 0
mRNA Capping R-HSA-72086 3.091956e-01 0.510 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.091956e-01 0.510 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.091956e-01 0.510 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 3.091956e-01 0.510 0 0
Platelet calcium homeostasis R-HSA-418360 3.091956e-01 0.510 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.119511e-01 0.506 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.119511e-01 0.506 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.164660e-01 0.500 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 3.235333e-01 0.490 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 3.236604e-01 0.490 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.273835e-01 0.485 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 3.306588e-01 0.481 0 0
Leishmania parasite growth and survival R-HSA-9664433 3.306588e-01 0.481 0 0
Signaling by WNT in cancer R-HSA-4791275 3.307794e-01 0.480 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.307794e-01 0.480 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.312280e-01 0.480 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.350665e-01 0.475 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.350665e-01 0.475 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.350665e-01 0.475 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.350665e-01 0.475 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.378240e-01 0.471 0 0
Activation of ATR in response to replication stress R-HSA-176187 3.378240e-01 0.471 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.378240e-01 0.471 0 0
Cardiogenesis R-HSA-9733709 3.378240e-01 0.471 0 0
G-protein beta:gamma signalling R-HSA-397795 3.378240e-01 0.471 0 0
Cell Cycle Checkpoints R-HSA-69620 3.380435e-01 0.471 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.447949e-01 0.462 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.447949e-01 0.462 0 0
Glutamate and glutamine metabolism R-HSA-8964539 3.447949e-01 0.462 0 0
Cellular Senescence R-HSA-2559583 3.507649e-01 0.455 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.516928e-01 0.454 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.516928e-01 0.454 0 0
RAF activation R-HSA-5673000 3.516928e-01 0.454 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.516928e-01 0.454 0 0
G alpha (q) signalling events R-HSA-416476 3.523551e-01 0.453 0 0
RNA Polymerase II Transcription R-HSA-73857 3.537336e-01 0.451 0 0
Platelet homeostasis R-HSA-418346 3.541577e-01 0.451 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.541577e-01 0.451 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.585185e-01 0.445 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.585185e-01 0.445 0 0
PERK regulates gene expression R-HSA-381042 3.585185e-01 0.445 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.585185e-01 0.445 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.617419e-01 0.442 0 0
Calmodulin induced events R-HSA-111933 3.652727e-01 0.437 0 0
CaM pathway R-HSA-111997 3.652727e-01 0.437 0 0
FGFR2 mutant receptor activation R-HSA-1839126 3.652727e-01 0.437 0 0
G2/M Transition R-HSA-69275 3.679504e-01 0.434 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.719563e-01 0.430 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.719563e-01 0.430 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.719563e-01 0.430 0 0
Mitotic G2-G2/M phases R-HSA-453274 3.736633e-01 0.428 0 0
FCERI mediated MAPK activation R-HSA-2871796 3.768096e-01 0.424 0 0
MET promotes cell motility R-HSA-8875878 3.785699e-01 0.422 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.785699e-01 0.422 0 0
Purine salvage R-HSA-74217 3.785699e-01 0.422 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.797240e-01 0.421 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.851142e-01 0.414 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.851142e-01 0.414 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.851142e-01 0.414 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 3.915900e-01 0.407 0 0
HIV Transcription Elongation R-HSA-167169 3.915900e-01 0.407 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.915900e-01 0.407 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.915900e-01 0.407 0 0
Glycogen metabolism R-HSA-8982491 3.915900e-01 0.407 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 3.915900e-01 0.407 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 3.954361e-01 0.403 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.043390e-01 0.393 0 0
HIV Transcription Initiation R-HSA-167161 4.043390e-01 0.393 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.043390e-01 0.393 0 0
MAP2K and MAPK activation R-HSA-5674135 4.043390e-01 0.393 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.043390e-01 0.393 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.043390e-01 0.393 0 0
Ca-dependent events R-HSA-111996 4.106135e-01 0.387 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 4.106135e-01 0.387 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.168223e-01 0.380 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.168223e-01 0.380 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.168223e-01 0.380 0 0
Cellular response to heat stress R-HSA-3371556 4.174486e-01 0.379 0 0
G1 Phase R-HSA-69236 4.229661e-01 0.374 0 0
Cyclin D associated events in G1 R-HSA-69231 4.229661e-01 0.374 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.246974e-01 0.372 0 0
MHC class II antigen presentation R-HSA-2132295 4.246974e-01 0.372 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.290456e-01 0.367 0 0
Nucleosome assembly R-HSA-774815 4.290456e-01 0.367 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.290456e-01 0.367 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.290456e-01 0.367 0 0
DAG and IP3 signaling R-HSA-1489509 4.290456e-01 0.367 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 4.290456e-01 0.367 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.350613e-01 0.361 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.350613e-01 0.361 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.350613e-01 0.361 0 0
Signaling by RAS mutants R-HSA-6802949 4.350613e-01 0.361 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.350613e-01 0.361 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.350613e-01 0.361 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.350613e-01 0.361 0 0
Signaling by TGFBR3 R-HSA-9839373 4.350613e-01 0.361 0 0
Diseases of DNA repair R-HSA-9675135 4.350613e-01 0.361 0 0
Apoptotic execution phase R-HSA-75153 4.350613e-01 0.361 0 0
Bacterial Infection Pathways R-HSA-9824439 4.379181e-01 0.359 0 0
Recycling pathway of L1 R-HSA-437239 4.410141e-01 0.356 0 0
G2/M Checkpoints R-HSA-69481 4.426129e-01 0.354 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 4.439431e-01 0.353 0 0
Metal ion SLC transporters R-HSA-425410 4.469045e-01 0.350 0 0
Gluconeogenesis R-HSA-70263 4.469045e-01 0.350 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 4.527332e-01 0.344 0 0
Mitotic Anaphase R-HSA-68882 4.549261e-01 0.342 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.576580e-01 0.339 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.585008e-01 0.339 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.637020e-01 0.334 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.698553e-01 0.328 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.698553e-01 0.328 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.698553e-01 0.328 0 0
Neurexins and neuroligins R-HSA-6794361 4.698553e-01 0.328 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.754435e-01 0.323 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.754435e-01 0.323 0 0
Meiotic synapsis R-HSA-1221632 4.754435e-01 0.323 0 0
Smooth Muscle Contraction R-HSA-445355 4.754435e-01 0.323 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.754435e-01 0.323 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.809169e-01 0.318 0 0
Glucuronidation R-HSA-156588 4.809732e-01 0.318 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.864449e-01 0.313 0 0
G alpha (z) signalling events R-HSA-418597 4.864449e-01 0.313 0 0
Paracetamol ADME R-HSA-9753281 4.864449e-01 0.313 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 4.899734e-01 0.310 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.918592e-01 0.308 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.918592e-01 0.308 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.918592e-01 0.308 0 0
Generic Transcription Pathway R-HSA-212436 4.970111e-01 0.304 0 0
Nuclear Envelope Breakdown R-HSA-2980766 4.972168e-01 0.303 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.972168e-01 0.303 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.977914e-01 0.303 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.025182e-01 0.299 0 0
RAB geranylgeranylation R-HSA-8873719 5.129550e-01 0.290 0 0
Glutathione conjugation R-HSA-156590 5.129550e-01 0.290 0 0
Signaling by Retinoic Acid R-HSA-5362517 5.129550e-01 0.290 0 0
Translation R-HSA-72766 5.166781e-01 0.287 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.180914e-01 0.286 0 0
PLC beta mediated events R-HSA-112043 5.180914e-01 0.286 0 0
Endogenous sterols R-HSA-211976 5.180914e-01 0.286 0 0
Nucleotide salvage R-HSA-8956321 5.180914e-01 0.286 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.180914e-01 0.286 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.231740e-01 0.281 0 0
tRNA processing in the nucleus R-HSA-6784531 5.231740e-01 0.281 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.231740e-01 0.281 0 0
Mitochondrial protein import R-HSA-1268020 5.231740e-01 0.281 0 0
Gastrulation R-HSA-9758941 5.272745e-01 0.278 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.282033e-01 0.277 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.282033e-01 0.277 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.282033e-01 0.277 0 0
Xenobiotics R-HSA-211981 5.331798e-01 0.273 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.331798e-01 0.273 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.336670e-01 0.273 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.381042e-01 0.269 0 0
Cellular response to hypoxia R-HSA-1234174 5.381042e-01 0.269 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.429769e-01 0.265 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.429769e-01 0.265 0 0
Death Receptor Signaling R-HSA-73887 5.431451e-01 0.265 0 0
G-protein mediated events R-HSA-112040 5.477986e-01 0.261 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.477986e-01 0.261 0 0
SARS-CoV-2 Infection R-HSA-9694516 5.479429e-01 0.261 1 0
Transcription of the HIV genome R-HSA-167172 5.525696e-01 0.258 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.525696e-01 0.258 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.525696e-01 0.258 0 0
Deubiquitination R-HSA-5688426 5.565724e-01 0.254 0 0
Interferon gamma signaling R-HSA-877300 5.586448e-01 0.253 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.665846e-01 0.247 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.665846e-01 0.247 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.665846e-01 0.247 0 0
Apoptosis R-HSA-109581 5.677647e-01 0.246 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 5.711585e-01 0.243 0 0
Separation of Sister Chromatids R-HSA-2467813 5.737694e-01 0.241 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.756845e-01 0.240 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.756845e-01 0.240 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.801630e-01 0.236 0 0
Centrosome maturation R-HSA-380287 5.845945e-01 0.233 0 0
Iron uptake and transport R-HSA-917937 5.845945e-01 0.233 0 0
Nuclear Receptor transcription pathway R-HSA-383280 5.976120e-01 0.224 0 0
Sensory processing of sound R-HSA-9659379 6.018604e-01 0.221 0 0
Ub-specific processing proteases R-HSA-5689880 6.028846e-01 0.220 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.060641e-01 0.217 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.085256e-01 0.216 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.102238e-01 0.215 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.143398e-01 0.212 0 0
M Phase R-HSA-68886 6.175071e-01 0.209 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.184126e-01 0.209 0 0
Influenza Infection R-HSA-168255 6.196257e-01 0.208 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.199923e-01 0.208 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.264303e-01 0.203 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.264303e-01 0.203 0 0
Meiosis R-HSA-1500620 6.264303e-01 0.203 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.264303e-01 0.203 0 0
Gene expression (Transcription) R-HSA-74160 6.275448e-01 0.202 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.303761e-01 0.200 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.304838e-01 0.200 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.342805e-01 0.198 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.342805e-01 0.198 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.381439e-01 0.195 0 0
Pyruvate metabolism R-HSA-70268 6.381439e-01 0.195 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 6.419668e-01 0.192 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.494924e-01 0.187 0 0
Downstream TCR signaling R-HSA-202424 6.494924e-01 0.187 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 6.540349e-01 0.184 1 1
Protein folding R-HSA-391251 6.604869e-01 0.180 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.604869e-01 0.180 0 0
HCMV Early Events R-HSA-9609690 6.641144e-01 0.178 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.739579e-01 0.171 0 0
Formation of a pool of free 40S subunits R-HSA-72689 6.746148e-01 0.171 0 0
Innate Immune System R-HSA-168249 6.752985e-01 0.171 0 0
Sphingolipid metabolism R-HSA-428157 6.763822e-01 0.170 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.814580e-01 0.167 0 0
Programmed Cell Death R-HSA-5357801 6.882855e-01 0.162 0 0
Glycolysis R-HSA-70171 6.914554e-01 0.160 0 0
Transmission across Chemical Synapses R-HSA-112315 7.040246e-01 0.152 0 0
Opioid Signalling R-HSA-111885 7.043016e-01 0.152 0 0
Membrane Trafficking R-HSA-199991 7.127154e-01 0.147 0 0
Drug ADME R-HSA-9748784 7.175645e-01 0.144 0 0
Extracellular matrix organization R-HSA-1474244 7.186697e-01 0.143 0 0
Stimuli-sensing channels R-HSA-2672351 7.196141e-01 0.143 0 0
TCR signaling R-HSA-202403 7.255160e-01 0.139 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.369519e-01 0.133 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 7.452168e-01 0.128 0 0
Neutrophil degranulation R-HSA-6798695 7.456511e-01 0.127 0 0
Chromatin modifying enzymes R-HSA-3247509 7.504107e-01 0.125 0 0
Glucose metabolism R-HSA-70326 7.505828e-01 0.125 0 0
Rab regulation of trafficking R-HSA-9007101 7.505828e-01 0.125 0 0
Mitochondrial biogenesis R-HSA-1592230 7.505828e-01 0.125 0 0
Homology Directed Repair R-HSA-5693538 7.532235e-01 0.123 0 0
Mitotic Prophase R-HSA-68875 7.584218e-01 0.120 0 0
Phase II - Conjugation of compounds R-HSA-156580 7.599839e-01 0.119 0 0
Chromosome Maintenance R-HSA-73886 7.609800e-01 0.119 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 7.609800e-01 0.119 0 0
Neuronal System R-HSA-112316 7.614052e-01 0.118 0 0
Formation of the cornified envelope R-HSA-6809371 7.684941e-01 0.114 0 0
Chromatin organization R-HSA-4839726 7.781853e-01 0.109 0 0
HCMV Infection R-HSA-9609646 7.799378e-01 0.108 0 0
Reproduction R-HSA-1474165 7.874031e-01 0.104 0 0
Developmental Cell Lineages R-HSA-9734767 8.016442e-01 0.096 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.018845e-01 0.096 0 0
Late Phase of HIV Life Cycle R-HSA-162599 8.168727e-01 0.088 0 0
MITF-M-dependent gene expression R-HSA-9856651 8.318501e-01 0.080 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.354000e-01 0.078 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.371470e-01 0.077 0 0
Protein localization R-HSA-9609507 8.371470e-01 0.077 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 8.405858e-01 0.075 0 0
PPARA activates gene expression R-HSA-1989781 8.405858e-01 0.075 0 0
HIV Life Cycle R-HSA-162587 8.439524e-01 0.074 0 0
HCMV Late Events R-HSA-9610379 8.439524e-01 0.074 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.439524e-01 0.074 0 0
Signaling by WNT R-HSA-195721 8.509556e-01 0.070 0 0
SLC transporter disorders R-HSA-5619102 8.597541e-01 0.066 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 8.597541e-01 0.066 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.656198e-01 0.063 0 0
tRNA processing R-HSA-72306 8.656198e-01 0.063 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 8.684605e-01 0.061 0 0
Vesicle-mediated transport R-HSA-5653656 8.750172e-01 0.058 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.759849e-01 0.058 0 0
Epigenetic regulation of gene expression R-HSA-212165 8.790829e-01 0.056 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.891386e-01 0.051 0 0
Ion channel transport R-HSA-983712 8.903179e-01 0.050 0 0
Cilium Assembly R-HSA-5617833 8.914848e-01 0.050 0 0
Co-inhibition by PD-1 R-HSA-389948 9.024955e-01 0.045 0 0
Signaling by ROBO receptors R-HSA-376176 9.055767e-01 0.043 0 0
Signaling by GPCR R-HSA-372790 9.060243e-01 0.043 0 0
Keratinization R-HSA-6805567 9.095350e-01 0.041 0 0
Muscle contraction R-HSA-397014 9.151651e-01 0.039 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 9.160689e-01 0.038 0 0
Neddylation R-HSA-8951664 9.229636e-01 0.035 0 0
GPCR downstream signalling R-HSA-388396 9.258621e-01 0.033 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 9.269837e-01 0.033 0 0
Biological oxidations R-HSA-211859 9.288826e-01 0.032 0 0
rRNA processing R-HSA-72312 9.315335e-01 0.031 0 0
Metabolism of nucleotides R-HSA-15869 9.344089e-01 0.029 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.417120e-01 0.026 0 0
Transport of small molecules R-HSA-382551 9.567236e-01 0.019 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.582256e-01 0.019 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.623676e-01 0.017 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.666461e-01 0.015 0 0
Metabolism of proteins R-HSA-392499 9.797601e-01 0.009 0 0
DNA Repair R-HSA-73894 9.827470e-01 0.008 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.881877e-01 0.005 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.885656e-01 0.005 0 0
G alpha (i) signalling events R-HSA-418594 9.897404e-01 0.004 0 0
Diseases of metabolism R-HSA-5668914 9.917421e-01 0.004 0 0
Post-translational protein modification R-HSA-597592 9.940368e-01 0.003 0 0
GPCR ligand binding R-HSA-500792 9.985911e-01 0.001 0 0
Metabolism of lipids R-HSA-556833 9.999906e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999990e-01 0.000 0 0
Metabolism R-HSA-1430728 9.999998e-01 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
HSF1 activation R-HSA-3371511 1.110223e-16 15.955 0 0
Attenuation phase R-HSA-3371568 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
HSF1-dependent transactivation R-HSA-3371571 1.110223e-16 15.955 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.110223e-16 15.955 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.110223e-16 15.955 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.551115e-16 15.256 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.551115e-16 15.256 0 0
Adherens junctions interactions R-HSA-418990 5.551115e-15 14.256 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.217249e-15 14.206 0 0
Cellular responses to stimuli R-HSA-8953897 5.884182e-15 14.230 0 0
G2/M Checkpoints R-HSA-69481 3.264056e-14 13.486 0 0
Cell-cell junction organization R-HSA-421270 8.770762e-14 13.057 0 0
Cell junction organization R-HSA-446728 8.448797e-14 13.073 0 0
Cell-Cell communication R-HSA-1500931 1.610934e-13 12.793 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.494671e-13 12.603 0 0
Cellular responses to stress R-HSA-2262752 5.559997e-13 12.255 0 0
Packaging Of Telomere Ends R-HSA-171306 6.892265e-13 12.162 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 6.892265e-13 12.162 0 0
DNA methylation R-HSA-5334118 1.288747e-12 11.890 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.325939e-12 11.877 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 3.084089e-12 11.511 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.060419e-12 11.391 0 0
EPH-Ephrin signaling R-HSA-2682334 4.807155e-12 11.318 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.889600e-12 11.162 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.889600e-12 11.162 0 0
Cell Cycle Checkpoints R-HSA-69620 8.742451e-12 11.058 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.138767e-11 10.944 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.450828e-11 10.838 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.367229e-11 10.864 0 0
Cleavage of the damaged purine R-HSA-110331 1.450828e-11 10.838 0 0
Depurination R-HSA-73927 1.837941e-11 10.736 0 0
Meiotic synapsis R-HSA-1221632 2.607192e-11 10.584 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.607192e-11 10.584 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.902578e-11 10.537 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.620071e-11 10.441 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 3.620071e-11 10.441 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.932132e-11 10.405 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.551981e-11 10.256 0 0
Depyrimidination R-HSA-73928 5.551981e-11 10.256 0 0
Defective pyroptosis R-HSA-9710421 6.829781e-11 10.166 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 7.536971e-11 10.123 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.907464e-11 10.050 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 8.907464e-11 10.050 0 0
Nucleosome assembly R-HSA-774815 1.020667e-10 9.991 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.020667e-10 9.991 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.240332e-10 9.906 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.501599e-10 9.823 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.811300e-10 9.742 0 0
DNA Double Strand Break Response R-HSA-5693606 2.678041e-10 9.572 0 0
Meiotic recombination R-HSA-912446 3.114352e-10 9.507 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.706956e-10 9.431 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.152044e-10 9.382 0 0
Gene Silencing by RNA R-HSA-211000 4.434475e-10 9.353 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.786302e-10 9.320 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.204497e-10 9.284 0 0
HDACs deacetylate histones R-HSA-3214815 6.140088e-10 9.212 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 9.919459e-10 9.004 0 0
Amyloid fiber formation R-HSA-977225 1.797389e-09 8.745 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.797389e-09 8.745 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.815597e-09 8.741 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.815597e-09 8.741 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.033392e-09 8.692 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.590976e-09 8.587 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 2.698028e-09 8.569 0 0
Meiosis R-HSA-1500620 2.918463e-09 8.535 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.205741e-09 8.494 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.207741e-09 8.376 0 0
Diseases of programmed cell death R-HSA-9645723 4.634657e-09 8.334 0 0
ESR-mediated signaling R-HSA-8939211 4.906669e-09 8.309 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.481010e-09 8.261 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.756200e-09 8.240 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.756200e-09 8.240 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.756200e-09 8.240 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.803141e-09 8.236 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.238474e-09 8.205 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.468537e-09 8.189 0 0
Cell Cycle R-HSA-1640170 8.795531e-09 8.056 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.931056e-09 8.049 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.161600e-08 7.935 0 0
Regulation of CDH1 Function R-HSA-9764561 1.225091e-08 7.912 0 0
RNA Polymerase I Transcription R-HSA-73864 1.472957e-08 7.832 0 0
Telomere Maintenance R-HSA-157579 1.495178e-08 7.825 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.856691e-08 7.731 0 0
HATs acetylate histones R-HSA-3214847 1.823985e-08 7.739 0 0
Ephrin signaling R-HSA-3928664 2.103174e-08 7.677 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.439511e-08 7.613 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.439511e-08 7.613 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.235271e-08 7.490 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.235271e-08 7.490 0 0
M Phase R-HSA-68886 3.976288e-08 7.401 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.088578e-08 7.293 0 0
Base Excision Repair R-HSA-73884 6.031208e-08 7.220 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.202770e-08 7.143 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 7.841118e-08 7.106 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.293990e-08 7.081 0 0
Protein ubiquitination R-HSA-8852135 1.165842e-07 6.933 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.165842e-07 6.933 0 0
Homology Directed Repair R-HSA-5693538 1.285089e-07 6.891 0 0
Co-inhibition by PD-1 R-HSA-389948 1.300858e-07 6.886 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.542132e-07 6.812 0 0
Mitotic Prophase R-HSA-68875 1.506639e-07 6.822 0 0
Chromosome Maintenance R-HSA-73886 1.629708e-07 6.788 0 0
Axon guidance R-HSA-422475 1.821184e-07 6.740 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.903082e-07 6.721 0 0
Signaling by NOTCH R-HSA-157118 2.045048e-07 6.689 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.293248e-07 6.482 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.618962e-07 6.441 0 0
Reproduction R-HSA-1474165 3.708752e-07 6.431 0 0
Activation of BH3-only proteins R-HSA-114452 4.228601e-07 6.374 0 0
Nervous system development R-HSA-9675108 5.610331e-07 6.251 0 0
Viral Infection Pathways R-HSA-9824446 6.860308e-07 6.164 1 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 9.810778e-07 6.008 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.067234e-06 5.972 0 0
Cell Cycle, Mitotic R-HSA-69278 1.278770e-06 5.893 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.342066e-06 5.872 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.669354e-06 5.777 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.761352e-06 5.754 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.761352e-06 5.754 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.761352e-06 5.754 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.803156e-06 5.744 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.891622e-06 5.723 0 0
DNA Replication R-HSA-69306 1.891622e-06 5.723 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.711127e-06 5.567 0 0
Developmental Biology R-HSA-1266738 2.735199e-06 5.563 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.954647e-06 5.529 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.222366e-06 5.374 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.222366e-06 5.374 0 0
Ub-specific processing proteases R-HSA-5689880 6.067632e-06 5.217 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.052695e-06 5.094 0 0
Cellular Senescence R-HSA-2559583 8.652910e-06 5.063 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.167325e-05 4.933 0 0
Infectious disease R-HSA-5663205 1.182139e-05 4.927 1 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.205517e-05 4.919 0 0
Signal Transduction R-HSA-162582 1.239289e-05 4.907 1 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.775133e-05 4.751 0 0
HCMV Early Events R-HSA-9609690 1.844907e-05 4.734 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.120460e-05 4.674 0 0
Chromatin organization R-HSA-4839726 3.645426e-05 4.438 0 0
Signaling by RAF1 mutants R-HSA-9656223 3.843792e-05 4.415 0 0
MAP2K and MAPK activation R-HSA-5674135 3.843792e-05 4.415 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.896918e-05 4.409 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.062517e-05 4.391 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.377674e-05 4.359 1 0
Deubiquitination R-HSA-5688426 4.554296e-05 4.342 0 0
Signaling by WNT R-HSA-195721 4.967984e-05 4.304 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 5.221111e-05 4.282 0 0
Immune System R-HSA-168256 5.563359e-05 4.255 1 0
Signaling downstream of RAS mutants R-HSA-9649948 6.543887e-05 4.184 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.543887e-05 4.184 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.543887e-05 4.184 0 0
Signaling by RAS mutants R-HSA-6802949 6.543887e-05 4.184 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.197723e-05 4.143 1 0
Signaling by VEGF R-HSA-194138 7.249060e-05 4.140 0 0
HCMV Late Events R-HSA-9610379 7.626127e-05 4.118 0 0
Chromatin modifying enzymes R-HSA-3247509 8.994816e-05 4.046 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.633648e-05 4.016 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.022704e-04 3.990 0 0
Smooth Muscle Contraction R-HSA-445355 1.266289e-04 3.897 0 0
PKR-mediated signaling R-HSA-9833482 1.287163e-04 3.890 0 0
Programmed Cell Death R-HSA-5357801 1.316962e-04 3.880 0 0
HCMV Infection R-HSA-9609646 1.578648e-04 3.802 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.678123e-04 3.775 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.685981e-04 3.773 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.748550e-04 3.757 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 1.781803e-04 3.749 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.799869e-04 3.745 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.203076e-04 3.657 0 0
Signaling by ERBB2 R-HSA-1227986 2.263235e-04 3.645 0 0
Activation of TRKA receptors R-HSA-187015 2.828648e-04 3.548 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.844499e-04 3.546 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.844499e-04 3.546 0 0
DNA Repair R-HSA-73894 3.096410e-04 3.509 0 0
Semaphorin interactions R-HSA-373755 2.844499e-04 3.546 0 0
Signaling by PTK6 R-HSA-8848021 2.844499e-04 3.546 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.844499e-04 3.546 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.275662e-04 3.485 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.292938e-04 3.482 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 3.454781e-04 3.462 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.514662e-04 3.454 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.536986e-04 3.451 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.641735e-04 3.439 0 0
Apoptosis R-HSA-109581 4.572252e-04 3.340 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.005689e-04 3.301 0 0
Glycolysis R-HSA-70171 5.159865e-04 3.287 0 0
mRNA Splicing R-HSA-72172 5.365294e-04 3.270 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.667018e-04 3.247 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.719431e-04 3.243 0 0
Signaling by ERBB4 R-HSA-1236394 6.038532e-04 3.219 0 0
Centrosome maturation R-HSA-380287 6.428675e-04 3.192 0 0
Long-term potentiation R-HSA-9620244 6.458837e-04 3.190 0 0
Manipulation of host energy metabolism R-HSA-9636667 6.672777e-04 3.176 0 0
Interleukin-12 signaling R-HSA-9020591 6.838080e-04 3.165 1 1
Muscle contraction R-HSA-397014 7.004317e-04 3.155 0 0
Gluconeogenesis R-HSA-70263 7.194756e-04 3.143 0 0
MAPK family signaling cascades R-HSA-5683057 7.261176e-04 3.139 1 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.485362e-04 3.126 0 0
SARS-CoV Infections R-HSA-9679506 8.935356e-04 3.049 1 0
Neutrophil degranulation R-HSA-6798695 9.827378e-04 3.008 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.010078e-03 2.996 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.010078e-03 2.996 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 1.119800e-03 2.951 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.421818e-03 2.847 0 0
Signaling by NTRKs R-HSA-166520 1.187670e-03 2.925 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.282877e-03 2.892 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.201523e-03 2.920 0 0
L1CAM interactions R-HSA-373760 1.283130e-03 2.892 0 0
Glucose metabolism R-HSA-70326 1.340031e-03 2.873 0 0
Disease R-HSA-1643685 1.148324e-03 2.940 1 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.398888e-03 2.854 0 0
Interleukin-12 family signaling R-HSA-447115 1.349658e-03 2.870 1 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.482692e-03 2.829 0 0
Integrin signaling R-HSA-354192 1.498794e-03 2.824 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.534379e-03 2.814 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.574935e-03 2.803 0 0
Striated Muscle Contraction R-HSA-390522 1.642774e-03 2.784 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.772483e-03 2.751 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.788353e-03 2.748 0 0
Protein methylation R-HSA-8876725 1.788353e-03 2.748 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.788353e-03 2.748 0 0
TRKA activation by NGF R-HSA-187042 1.823676e-03 2.739 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.827747e-03 2.738 0 0
Signalling to ERKs R-HSA-187687 1.959064e-03 2.708 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.959064e-03 2.708 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.055540e-03 2.687 0 0
Prolonged ERK activation events R-HSA-169893 2.067103e-03 2.685 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.106109e-03 2.677 1 0
Cytokine Signaling in Immune system R-HSA-1280215 2.319812e-03 2.635 1 0
SARS-CoV-2 Infection R-HSA-9694516 2.339681e-03 2.631 1 0
SHC1 events in ERBB4 signaling R-HSA-1250347 2.371440e-03 2.625 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.371440e-03 2.625 0 0
MTF1 activates gene expression R-HSA-5660489 2.604877e-03 2.584 0 0
Signaling by Hippo R-HSA-2028269 2.702132e-03 2.568 0 0
Signaling by Interleukins R-HSA-449147 2.962598e-03 2.528 1 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.156437e-03 2.501 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.203811e-03 2.494 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.286156e-03 2.483 1 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.378404e-03 2.471 0 0
Regulation of signaling by CBL R-HSA-912631 3.445466e-03 2.463 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 3.646301e-03 2.438 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 3.647907e-03 2.438 0 0
Parasite infection R-HSA-9664407 3.647907e-03 2.438 0 0
Leishmania phagocytosis R-HSA-9664417 3.647907e-03 2.438 0 0
G2/M Transition R-HSA-69275 4.292410e-03 2.367 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.379288e-03 2.359 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.474031e-03 2.349 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.544395e-03 2.343 0 0
NGF-independant TRKA activation R-HSA-187024 4.556478e-03 2.341 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.775147e-03 2.321 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.775823e-03 2.321 0 0
Mitotic Prometaphase R-HSA-68877 5.224192e-03 2.282 0 0
Potential therapeutics for SARS R-HSA-9679191 5.238614e-03 2.281 1 1
Nef and signal transduction R-HSA-164944 5.720339e-03 2.243 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.720339e-03 2.243 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 7.005317e-03 2.155 0 0
Translation initiation complex formation R-HSA-72649 7.693492e-03 2.114 0 0
CHL1 interactions R-HSA-447041 7.005317e-03 2.155 0 0
Adaptive Immune System R-HSA-1280218 6.858859e-03 2.164 0 0
Intracellular signaling by second messengers R-HSA-9006925 5.782160e-03 2.238 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.005317e-03 2.155 0 0
Post NMDA receptor activation events R-HSA-438064 7.185823e-03 2.144 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 8.408290e-03 2.075 0 0
Formation of annular gap junctions R-HSA-196025 8.408290e-03 2.075 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.571658e-03 2.067 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 9.197823e-03 2.036 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.512963e-03 2.022 0 0
ARMS-mediated activation R-HSA-170984 9.926195e-03 2.003 0 0
Gap junction degradation R-HSA-190873 9.926195e-03 2.003 0 0
GP1b-IX-V activation signalling R-HSA-430116 9.926195e-03 2.003 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 9.926195e-03 2.003 0 0
Metabolism of RNA R-HSA-8953854 1.024349e-02 1.990 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.044179e-02 1.981 0 0
PI3K/AKT activation R-HSA-198203 1.155603e-02 1.937 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 1.155603e-02 1.937 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.159161e-02 1.936 0 0
FOXO-mediated transcription R-HSA-9614085 1.238044e-02 1.907 0 0
Extracellular matrix organization R-HSA-1474244 1.264079e-02 1.898 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.292494e-02 1.889 0 0
PECAM1 interactions R-HSA-210990 1.329484e-02 1.876 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.375568e-02 1.862 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.475173e-02 1.831 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 1.513973e-02 1.820 0 0
Innate Immune System R-HSA-168249 1.621272e-02 1.790 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.671720e-02 1.777 0 0
GPVI-mediated activation cascade R-HSA-114604 1.671720e-02 1.777 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.799967e-02 1.745 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.882228e-02 1.725 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.913645e-02 1.718 0 0
Frs2-mediated activation R-HSA-170968 1.913645e-02 1.718 0 0
Signaling by NOTCH4 R-HSA-9013694 1.949899e-02 1.710 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 1.992738e-02 1.701 0 0
Autophagy R-HSA-9612973 2.193095e-02 1.659 0 0
Erythropoietin activates RAS R-HSA-9027284 2.352409e-02 1.628 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.352409e-02 1.628 0 0
Signaling by FGFR2 R-HSA-5654738 2.445052e-02 1.612 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.585783e-02 1.587 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.597971e-02 1.585 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.597971e-02 1.585 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.678544e-02 1.572 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.828138e-02 1.548 0 0
Response to metal ions R-HSA-5660526 2.828138e-02 1.548 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.003192e-02 1.522 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.003192e-02 1.522 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.079222e-02 1.512 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.079222e-02 1.512 0 0
Recycling pathway of L1 R-HSA-437239 3.145244e-02 1.502 0 0
Pyruvate metabolism R-HSA-70268 3.213761e-02 1.493 0 0
NTRK3 as a dependence receptor R-HSA-9603505 3.639835e-02 1.439 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.823576e-02 1.317 0 0
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357 4.823576e-02 1.317 0 0
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046 4.823576e-02 1.317 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.823576e-02 1.317 0 0
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909 4.823576e-02 1.317 0 0
NTF3 activates NTRK3 signaling R-HSA-9034013 4.823576e-02 1.317 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.823576e-02 1.317 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.823576e-02 1.317 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.823576e-02 1.317 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.823576e-02 1.317 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.823576e-02 1.317 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.823576e-02 1.317 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.823576e-02 1.317 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.823576e-02 1.317 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.823576e-02 1.317 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.165936e-02 1.380 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.165936e-02 1.380 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.457024e-02 1.351 0 0
FGFR2 alternative splicing R-HSA-6803529 4.755418e-02 1.323 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.755418e-02 1.323 0 0
mRNA 3'-end processing R-HSA-72187 3.907327e-02 1.408 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 4.457024e-02 1.351 1 1
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.823576e-02 1.317 0 0
Signalling to RAS R-HSA-167044 4.165936e-02 1.380 0 0
Degradation of CDH1 R-HSA-9766229 3.439752e-02 1.463 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.606584e-02 1.443 0 0
Selective autophagy R-HSA-9663891 3.318719e-02 1.479 0 0
Platelet degranulation R-HSA-114608 3.255228e-02 1.487 0 0
Gap junction trafficking and regulation R-HSA-157858 3.439752e-02 1.463 0 0
Rap1 signalling R-HSA-392517 3.606584e-02 1.443 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.870949e-02 1.412 0 0
Leishmania infection R-HSA-9658195 3.471011e-02 1.460 0 0
Parasitic Infection Pathways R-HSA-9824443 3.471011e-02 1.460 0 0
Signaling by EGFR R-HSA-177929 4.578252e-02 1.339 0 0
Cilium Assembly R-HSA-5617833 4.664198e-02 1.331 0 0
RNA Polymerase II Transcription R-HSA-73857 3.270574e-02 1.485 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.165936e-02 1.380 0 0
Signal transduction by L1 R-HSA-445144 3.882379e-02 1.411 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.035294e-02 1.394 0 0
Signaling by FGFR R-HSA-190236 4.733653e-02 1.325 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 3.907327e-02 1.408 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.842562e-02 1.315 1 1
Syndecan interactions R-HSA-3000170 5.060897e-02 1.296 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.060897e-02 1.296 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.491386e-02 1.260 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.548679e-02 1.256 0 0
RSV-host interactions R-HSA-9833110 5.691434e-02 1.245 1 0
MicroRNA (miRNA) biogenesis R-HSA-203927 5.692243e-02 1.245 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.692243e-02 1.245 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.692243e-02 1.245 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 5.692243e-02 1.245 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.992848e-02 1.222 0 0
PLC-gamma1 signalling R-HSA-167021 5.992848e-02 1.222 0 0
Signalling to STAT3 R-HSA-198745 5.992848e-02 1.222 0 0
MET interacts with TNS proteins R-HSA-8875513 5.992848e-02 1.222 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.017689e-02 1.221 0 0
MET activates PTK2 signaling R-HSA-8874081 6.017689e-02 1.221 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.017689e-02 1.221 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.282039e-02 1.202 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.282039e-02 1.202 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 6.282039e-02 1.202 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.349376e-02 1.197 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.349376e-02 1.197 0 0
Interferon Signaling R-HSA-913531 6.513366e-02 1.186 1 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.687103e-02 1.175 0 0
Regulated Necrosis R-HSA-5218859 6.903187e-02 1.161 0 0
Signaling by Erythropoietin R-HSA-9006335 7.030674e-02 1.153 0 0
Late endosomal microautophagy R-HSA-9615710 7.030674e-02 1.153 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.030674e-02 1.153 1 1
Regulation of CDH11 Expression and Function R-HSA-9759475 7.030674e-02 1.153 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.030674e-02 1.153 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 7.147827e-02 1.146 0 0
Regulation of gap junction activity R-HSA-191650 7.147827e-02 1.146 0 0
NADE modulates death signalling R-HSA-205025 7.147827e-02 1.146 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 7.147827e-02 1.146 0 0
Gene expression (Transcription) R-HSA-74160 7.213348e-02 1.142 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 7.225974e-02 1.141 0 0
Membrane Trafficking R-HSA-199991 7.322464e-02 1.135 0 0
DAP12 signaling R-HSA-2424491 7.379897e-02 1.132 0 0
Budding and maturation of HIV virion R-HSA-162588 7.734581e-02 1.112 0 0
Molecules associated with elastic fibres R-HSA-2129379 7.734581e-02 1.112 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.734581e-02 1.112 1 1
Generic Transcription Pathway R-HSA-212436 7.807153e-02 1.108 0 0
Cap-dependent Translation Initiation R-HSA-72737 7.893211e-02 1.103 0 0
Eukaryotic Translation Initiation R-HSA-72613 7.893211e-02 1.103 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.001949e-02 1.097 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.001949e-02 1.097 0 0
IRS activation R-HSA-74713 8.288685e-02 1.082 0 0
NTRK2 activates RAC1 R-HSA-9032759 8.288685e-02 1.082 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 8.288685e-02 1.082 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 8.288685e-02 1.082 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 8.288685e-02 1.082 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 8.288685e-02 1.082 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 8.459597e-02 1.073 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.459597e-02 1.073 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.829570e-02 1.054 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 9.415596e-02 1.026 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 9.415596e-02 1.026 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 1.052873e-01 0.978 0 0
Erythropoietin activates STAT5 R-HSA-9027283 1.052873e-01 0.978 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 1.162825e-01 0.934 0 0
SOS-mediated signalling R-HSA-112412 1.162825e-01 0.934 0 0
Recycling of eIF2:GDP R-HSA-72731 1.162825e-01 0.934 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.162825e-01 0.934 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.271433e-01 0.896 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 1.271433e-01 0.896 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.271433e-01 0.896 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.271433e-01 0.896 0 0
Lipophagy R-HSA-9613354 1.378712e-01 0.861 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 1.484680e-01 0.828 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.484680e-01 0.828 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.589351e-01 0.799 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 1.589351e-01 0.799 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.692743e-01 0.771 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.443396e-01 0.841 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.701721e-01 0.769 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.745515e-01 0.758 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.117842e-01 0.952 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.117842e-01 0.952 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.446537e-01 0.840 0 0
RAF activation R-HSA-5673000 9.204286e-02 1.036 0 0
Aggrephagy R-HSA-9646399 1.154285e-01 0.938 0 0
Nucleotide Excision Repair R-HSA-5696398 1.771958e-01 0.752 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.484680e-01 0.828 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.378712e-01 0.861 0 0
Regulation of CDH11 function R-HSA-9762292 1.484680e-01 0.828 0 0
Peptide chain elongation R-HSA-156902 1.197095e-01 0.922 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.204286e-02 1.036 0 0
Generation of second messenger molecules R-HSA-202433 1.154285e-01 0.938 0 0
PTK6 Expression R-HSA-8849473 1.162825e-01 0.934 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.271433e-01 0.896 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 1.692743e-01 0.771 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.154285e-01 0.938 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.194617e-01 0.923 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.276307e-01 0.894 0 0
FCGR activation R-HSA-2029481 1.361546e-01 0.866 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.745515e-01 0.758 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 9.415596e-02 1.026 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.591923e-01 0.798 0 0
Signaling by SCF-KIT R-HSA-1433557 1.317636e-01 0.880 0 0
Regulation of PTEN localization R-HSA-8948747 1.162825e-01 0.934 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 1.271433e-01 0.896 0 0
Josephin domain DUBs R-HSA-5689877 1.484680e-01 0.828 0 0
vRNP Assembly R-HSA-192905 1.589351e-01 0.799 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.154285e-01 0.938 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.400950e-01 0.854 0 0
Signal attenuation R-HSA-74749 1.484680e-01 0.828 0 0
DAP12 interactions R-HSA-2172127 1.359270e-01 0.867 0 0
MET promotes cell motility R-HSA-8875878 1.074721e-01 0.969 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.589351e-01 0.799 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.711317e-01 0.767 0 0
Translation R-HSA-72766 1.078744e-01 0.967 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.484680e-01 0.828 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 1.692743e-01 0.771 0 0
Developmental Cell Lineages R-HSA-9734767 1.402621e-01 0.853 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.204286e-02 1.036 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.035520e-01 0.985 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.745515e-01 0.758 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.676842e-01 0.776 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 1.692743e-01 0.771 0 0
Co-stimulation by CD28 R-HSA-389356 1.528580e-01 0.816 0 0
Netrin mediated repulsion signals R-HSA-418886 1.162825e-01 0.934 0 0
NF-kB is activated and signals survival R-HSA-209560 1.692743e-01 0.771 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.235295e-01 0.908 0 0
Macroautophagy R-HSA-1632852 1.335057e-01 0.875 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.504150e-01 0.823 0 0
Maturation of protein E R-HSA-9683683 9.415596e-02 1.026 0 0
Maturation of protein E R-HSA-9694493 9.415596e-02 1.026 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 9.415596e-02 1.026 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 1.378712e-01 0.861 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 1.378712e-01 0.861 0 0
Gap junction trafficking R-HSA-190828 1.359270e-01 0.867 0 0
GPER1 signaling R-HSA-9634597 1.528580e-01 0.816 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.475251e-01 0.831 0 0
Elastic fibre formation R-HSA-1566948 1.074721e-01 0.969 0 0
Hemostasis R-HSA-109582 1.261371e-01 0.899 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.271433e-01 0.896 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.378712e-01 0.861 0 0
Azathioprine ADME R-HSA-9748787 1.614721e-01 0.792 0 0
Signaling by MET R-HSA-6806834 9.657958e-02 1.015 0 0
Mitotic Anaphase R-HSA-68882 1.695901e-01 0.771 0 0
Pexophagy R-HSA-9664873 1.484680e-01 0.828 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.015486e-01 0.993 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.716145e-01 0.765 0 0
Vesicle-mediated transport R-HSA-5653656 1.482867e-01 0.829 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.091890e-01 0.962 0 0
Receptor Mediated Mitophagy R-HSA-8934903 1.484680e-01 0.828 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.562490e-01 0.806 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.418012e-01 0.848 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.271433e-01 0.896 0 0
G1 Phase R-HSA-69236 1.359270e-01 0.867 0 0
Cyclin D associated events in G1 R-HSA-69231 1.359270e-01 0.867 0 0
Signaling by Leptin R-HSA-2586552 1.484680e-01 0.828 0 0
Interleukin-2 signaling R-HSA-9020558 1.589351e-01 0.799 0 0
Somitogenesis R-HSA-9824272 1.401194e-01 0.854 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.378712e-01 0.861 0 0
Signaling by FGFR4 R-HSA-5654743 1.317636e-01 0.880 0 0
Signaling by FGFR3 R-HSA-5654741 1.401194e-01 0.854 0 0
Mitophagy R-HSA-5205647 9.204286e-02 1.036 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.378841e-01 0.860 1 1
Influenza Infection R-HSA-168255 1.005924e-01 0.997 0 0
RET signaling R-HSA-8853659 9.967266e-02 1.001 0 0
Bacterial Infection Pathways R-HSA-9824439 1.390749e-01 0.857 0 0
Dissolution of Fibrin Clot R-HSA-75205 1.589351e-01 0.799 0 0
FLT3 Signaling R-HSA-9607240 1.194617e-01 0.923 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.359270e-01 0.867 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.615893e-01 0.792 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.789489e-01 0.747 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.794869e-01 0.746 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 1.794869e-01 0.746 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.794869e-01 0.746 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.794869e-01 0.746 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.794869e-01 0.746 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.794869e-01 0.746 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.794869e-01 0.746 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.794869e-01 0.746 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.794869e-01 0.746 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.794869e-01 0.746 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.794869e-01 0.746 0 0
Signaling by TGFB family members R-HSA-9006936 1.797121e-01 0.745 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.833188e-01 0.737 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.833188e-01 0.737 1 1
Signaling by ALK in cancer R-HSA-9700206 1.833188e-01 0.737 1 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.877935e-01 0.726 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.877935e-01 0.726 0 0
Signaling by FGFR1 R-HSA-5654736 1.877935e-01 0.726 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.894977e-01 0.722 0 0
Separation of Sister Chromatids R-HSA-2467813 1.895375e-01 0.722 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.895747e-01 0.722 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.895747e-01 0.722 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.895747e-01 0.722 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.922386e-01 0.716 0 0
HIV Infection R-HSA-162906 1.923594e-01 0.716 0 0
TCR signaling R-HSA-202403 1.926072e-01 0.715 0 0
Dual incision in TC-NER R-HSA-6782135 1.966975e-01 0.706 0 0
FCERI mediated MAPK activation R-HSA-2871796 1.988644e-01 0.701 0 0
Retrograde neurotrophin signalling R-HSA-177504 1.995390e-01 0.700 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.995390e-01 0.700 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 1.995390e-01 0.700 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.995390e-01 0.700 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.995390e-01 0.700 0 0
Regulation of KIT signaling R-HSA-1433559 1.995390e-01 0.700 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.995390e-01 0.700 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.995390e-01 0.700 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.995390e-01 0.700 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 1.995390e-01 0.700 0 0
Signal regulatory protein family interactions R-HSA-391160 1.995390e-01 0.700 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.071289e-01 0.684 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 2.093814e-01 0.679 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.093814e-01 0.679 0 0
Translesion synthesis by REV1 R-HSA-110312 2.093814e-01 0.679 0 0
DCC mediated attractive signaling R-HSA-418885 2.093814e-01 0.679 0 0
p38MAPK events R-HSA-171007 2.093814e-01 0.679 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.093814e-01 0.679 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.093814e-01 0.679 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.093814e-01 0.679 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 2.093814e-01 0.679 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.093814e-01 0.679 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.093814e-01 0.679 0 0
p75NTR signals via NF-kB R-HSA-193639 2.093814e-01 0.679 0 0
Other semaphorin interactions R-HSA-416700 2.093814e-01 0.679 0 0
Formation of paraxial mesoderm R-HSA-9793380 2.101472e-01 0.677 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 2.147135e-01 0.668 0 0
Translesion synthesis by POLI R-HSA-5656121 2.191034e-01 0.659 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.191034e-01 0.659 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.191034e-01 0.659 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.191034e-01 0.659 0 0
Regulation of BACH1 activity R-HSA-9708530 2.191034e-01 0.659 0 0
Negative regulation of FLT3 R-HSA-9706369 2.191034e-01 0.659 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.191648e-01 0.659 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 2.236863e-01 0.650 0 0
Translesion synthesis by POLK R-HSA-5655862 2.287064e-01 0.641 0 0
Fibronectin matrix formation R-HSA-1566977 2.287064e-01 0.641 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.287064e-01 0.641 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 2.287064e-01 0.641 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.287064e-01 0.641 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.340700e-01 0.631 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 2.340700e-01 0.631 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 2.377048e-01 0.624 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.381920e-01 0.623 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.381920e-01 0.623 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.381920e-01 0.623 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 2.381920e-01 0.623 0 0
Uptake and function of anthrax toxins R-HSA-5210891 2.381920e-01 0.623 0 0
Glycogen storage diseases R-HSA-3229121 2.381920e-01 0.623 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.418361e-01 0.616 0 0
Host Interactions of HIV factors R-HSA-162909 2.438644e-01 0.613 0 0
Organelle biogenesis and maintenance R-HSA-1852241 2.457293e-01 0.610 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.463854e-01 0.608 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.475614e-01 0.606 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.475614e-01 0.606 0 0
GAB1 signalosome R-HSA-180292 2.475614e-01 0.606 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.475614e-01 0.606 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.509379e-01 0.600 0 0
Transmission across Chemical Synapses R-HSA-112315 2.518505e-01 0.599 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 2.537242e-01 0.596 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.542882e-01 0.595 0 0
ECM proteoglycans R-HSA-3000178 2.554928e-01 0.593 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.568162e-01 0.590 0 0
Translesion Synthesis by POLH R-HSA-110320 2.568162e-01 0.590 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.568162e-01 0.590 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 2.568162e-01 0.590 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.568162e-01 0.590 0 0
The NLRP3 inflammasome R-HSA-844456 2.568162e-01 0.590 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.600493e-01 0.585 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 2.600493e-01 0.585 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 2.659578e-01 0.575 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.659578e-01 0.575 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.659578e-01 0.575 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.659578e-01 0.575 0 0
Negative regulation of MET activity R-HSA-6807004 2.659578e-01 0.575 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.659578e-01 0.575 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.659578e-01 0.575 0 0
Glycogen synthesis R-HSA-3322077 2.659578e-01 0.575 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.691645e-01 0.570 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.737217e-01 0.563 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.749874e-01 0.561 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.749874e-01 0.561 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 2.749874e-01 0.561 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.749874e-01 0.561 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.749874e-01 0.561 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.749874e-01 0.561 0 0
Basigin interactions R-HSA-210991 2.749874e-01 0.561 0 0
UCH proteinases R-HSA-5689603 2.782779e-01 0.556 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.839065e-01 0.547 0 0
Assembly Of The HIV Virion R-HSA-175474 2.839065e-01 0.547 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.839065e-01 0.547 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.839065e-01 0.547 0 0
Ribavirin ADME R-HSA-9755088 2.839065e-01 0.547 0 0
Integrin cell surface interactions R-HSA-216083 2.873841e-01 0.542 0 0
Sensory processing of sound R-HSA-9659379 2.919329e-01 0.535 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 2.919329e-01 0.535 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.927165e-01 0.534 1 1
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.927165e-01 0.534 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.927165e-01 0.534 0 0
Signaling by KIT in disease R-HSA-9669938 2.927165e-01 0.534 0 0
mTORC1-mediated signalling R-HSA-166208 2.927165e-01 0.534 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.927165e-01 0.534 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 2.951126e-01 0.530 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.014186e-01 0.521 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.014186e-01 0.521 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.014186e-01 0.521 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.014186e-01 0.521 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.014186e-01 0.521 0 0
Formation of the ureteric bud R-HSA-9830674 3.014186e-01 0.521 0 0
Growth hormone receptor signaling R-HSA-982772 3.014186e-01 0.521 0 0
PTEN Regulation R-HSA-6807070 3.037031e-01 0.518 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 3.100141e-01 0.509 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.100141e-01 0.509 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.100141e-01 0.509 0 0
Mitochondrial RNA degradation R-HSA-9836573 3.100141e-01 0.509 0 0
Neurodegenerative Diseases R-HSA-8863678 3.100141e-01 0.509 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.100141e-01 0.509 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.146105e-01 0.502 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.171388e-01 0.499 0 0
TGFBR3 expression R-HSA-9839394 3.185044e-01 0.497 0 0
Laminin interactions R-HSA-3000157 3.185044e-01 0.497 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.185044e-01 0.497 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.185044e-01 0.497 0 0
Interleukin-7 signaling R-HSA-1266695 3.185044e-01 0.497 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.236400e-01 0.490 0 0
Metalloprotease DUBs R-HSA-5689901 3.268908e-01 0.486 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.268908e-01 0.486 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.268908e-01 0.486 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.351745e-01 0.475 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.351745e-01 0.475 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.351745e-01 0.475 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 3.351745e-01 0.475 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 3.351745e-01 0.475 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 3.351745e-01 0.475 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.351745e-01 0.475 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.433567e-01 0.464 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.433567e-01 0.464 0 0
HIV elongation arrest and recovery R-HSA-167287 3.433567e-01 0.464 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.433567e-01 0.464 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.433567e-01 0.464 0 0
Inflammasomes R-HSA-622312 3.433567e-01 0.464 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.433567e-01 0.464 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.433567e-01 0.464 0 0
Downstream TCR signaling R-HSA-202424 3.460739e-01 0.461 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.505329e-01 0.455 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.514388e-01 0.454 0 0
mRNA Capping R-HSA-72086 3.514388e-01 0.454 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.514388e-01 0.454 0 0
Protein localization R-HSA-9609507 3.540951e-01 0.451 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 3.549816e-01 0.450 0 0
Death Receptor Signaling R-HSA-73887 3.574474e-01 0.447 0 0
Protein folding R-HSA-391251 3.594196e-01 0.444 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 3.594218e-01 0.444 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 3.594218e-01 0.444 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 3.594218e-01 0.444 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 3.638465e-01 0.439 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.673071e-01 0.435 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 3.673071e-01 0.435 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.673071e-01 0.435 0 0
EGFR downregulation R-HSA-182971 3.673071e-01 0.435 0 0
Downstream signal transduction R-HSA-186763 3.673071e-01 0.435 0 0
HIV Life Cycle R-HSA-162587 3.674896e-01 0.435 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 3.708315e-01 0.431 0 0
Cellular response to starvation R-HSA-9711097 3.708315e-01 0.431 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 3.726653e-01 0.429 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 3.750958e-01 0.426 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.750958e-01 0.426 0 0
Eukaryotic Translation Termination R-HSA-72764 3.770566e-01 0.424 0 0
rRNA processing R-HSA-72312 3.785337e-01 0.422 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.827891e-01 0.417 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.858007e-01 0.414 0 0
Vpu mediated degradation of CD4 R-HSA-180534 3.903881e-01 0.409 0 0
Dual Incision in GG-NER R-HSA-5696400 3.978941e-01 0.400 0 0
eNOS activation R-HSA-203615 3.978941e-01 0.400 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.978941e-01 0.400 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.978941e-01 0.400 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.978941e-01 0.400 0 0
Calnexin/calreticulin cycle R-HSA-901042 3.978941e-01 0.400 0 0
Signaling by NOTCH2 R-HSA-1980145 3.978941e-01 0.400 0 0
Signal amplification R-HSA-392518 3.978941e-01 0.400 0 0
Hedgehog 'off' state R-HSA-5610787 3.988163e-01 0.399 0 0
ABC-family proteins mediated transport R-HSA-382556 3.988163e-01 0.399 0 0
Neuronal System R-HSA-112316 4.007041e-01 0.397 0 0
Selenocysteine synthesis R-HSA-2408557 4.031266e-01 0.395 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.031266e-01 0.395 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.053081e-01 0.392 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 4.053081e-01 0.392 0 0
Regulation of Apoptosis R-HSA-169911 4.053081e-01 0.392 0 0
PERK regulates gene expression R-HSA-381042 4.053081e-01 0.392 0 0
Oncogene Induced Senescence R-HSA-2559585 4.053081e-01 0.392 0 0
Viral mRNA Translation R-HSA-192823 4.117033e-01 0.385 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.126312e-01 0.384 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.126312e-01 0.384 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.126312e-01 0.384 0 0
RUNX2 regulates bone development R-HSA-8941326 4.126312e-01 0.384 0 0
FGFR2 mutant receptor activation R-HSA-1839126 4.126312e-01 0.384 0 0
FLT3 signaling in disease R-HSA-9682385 4.126312e-01 0.384 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.171939e-01 0.380 0 0
Degradation of DVL R-HSA-4641258 4.198647e-01 0.377 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.198647e-01 0.377 0 0
Degradation of AXIN R-HSA-4641257 4.198647e-01 0.377 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 4.198647e-01 0.377 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.198647e-01 0.377 0 0
Leishmania parasite growth and survival R-HSA-9664433 4.237350e-01 0.373 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 4.237350e-01 0.373 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 4.270094e-01 0.370 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.340667e-01 0.362 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 4.340667e-01 0.362 0 0
Stabilization of p53 R-HSA-69541 4.340667e-01 0.362 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.340667e-01 0.362 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.340667e-01 0.362 0 0
Signaling by ALK R-HSA-201556 4.340667e-01 0.362 0 0
RAS processing R-HSA-9648002 4.340667e-01 0.362 0 0
Plasma lipoprotein clearance R-HSA-8964043 4.340667e-01 0.362 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.410374e-01 0.356 0 0
HIV Transcription Elongation R-HSA-167169 4.410374e-01 0.356 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.410374e-01 0.356 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 4.410374e-01 0.356 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.410374e-01 0.356 0 0
Glycogen metabolism R-HSA-8982491 4.410374e-01 0.356 0 0
Interleukin-2 family signaling R-HSA-451927 4.410374e-01 0.356 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.479227e-01 0.349 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.479227e-01 0.349 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.479227e-01 0.349 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.479227e-01 0.349 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 4.479227e-01 0.349 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.536357e-01 0.343 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.536357e-01 0.343 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 4.547236e-01 0.342 0 0
HIV Transcription Initiation R-HSA-167161 4.547236e-01 0.342 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 4.547236e-01 0.342 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.547236e-01 0.342 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 4.547236e-01 0.342 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 4.547236e-01 0.342 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 4.547236e-01 0.342 0 0
Translation of Structural Proteins R-HSA-9683701 4.547236e-01 0.342 0 0
MTOR signalling R-HSA-165159 4.614412e-01 0.336 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 4.615143e-01 0.336 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.680764e-01 0.330 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 4.680764e-01 0.330 0 0
Interferon alpha/beta signaling R-HSA-909733 4.739588e-01 0.324 1 1
Role of phospholipids in phagocytosis R-HSA-2029485 4.739588e-01 0.324 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 4.746303e-01 0.324 0 0
Netrin-1 signaling R-HSA-373752 4.746303e-01 0.324 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.811038e-01 0.318 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.811038e-01 0.318 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.811038e-01 0.318 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 4.811038e-01 0.318 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 4.811038e-01 0.318 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 4.811038e-01 0.318 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.811038e-01 0.318 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 4.811038e-01 0.318 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 4.874979e-01 0.312 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.874979e-01 0.312 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.874979e-01 0.312 0 0
Signaling by TGFBR3 R-HSA-9839373 4.874979e-01 0.312 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 4.874979e-01 0.312 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 4.874979e-01 0.312 0 0
Apoptotic execution phase R-HSA-75153 4.874979e-01 0.312 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.898871e-01 0.310 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 4.938137e-01 0.306 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.938137e-01 0.306 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.000520e-01 0.301 0 0
DNA Damage Bypass R-HSA-73893 5.062138e-01 0.296 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 5.062138e-01 0.296 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.062138e-01 0.296 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.062138e-01 0.296 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.062138e-01 0.296 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.123000e-01 0.290 0 0
PI3K Cascade R-HSA-109704 5.123000e-01 0.290 0 0
Signaling by FGFR2 in disease R-HSA-5655253 5.123000e-01 0.290 0 0
Signaling by ROBO receptors R-HSA-376176 5.182118e-01 0.285 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 5.183116e-01 0.285 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.183116e-01 0.285 0 0
Hedgehog ligand biogenesis R-HSA-5358346 5.183116e-01 0.285 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.242494e-01 0.280 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.242494e-01 0.280 0 0
Orc1 removal from chromatin R-HSA-68949 5.242494e-01 0.280 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.242494e-01 0.280 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.242494e-01 0.280 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.301144e-01 0.276 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 5.301144e-01 0.276 0 0
Nucleotide biosynthesis R-HSA-8956320 5.301144e-01 0.276 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.359075e-01 0.271 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.416295e-01 0.266 0 0
Signaling by NOTCH3 R-HSA-9012852 5.416295e-01 0.266 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.472813e-01 0.262 0 0
TNF signaling R-HSA-75893 5.472813e-01 0.262 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.472813e-01 0.262 0 0
NRAGE signals death through JNK R-HSA-193648 5.472813e-01 0.262 0 0
IRS-mediated signalling R-HSA-112399 5.528638e-01 0.257 0 0
Dectin-2 family R-HSA-5621480 5.528638e-01 0.257 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.528638e-01 0.257 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 5.583778e-01 0.253 0 0
Peroxisomal protein import R-HSA-9033241 5.638241e-01 0.249 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.648347e-01 0.248 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.692036e-01 0.245 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.692036e-01 0.245 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.692036e-01 0.245 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.692036e-01 0.245 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.692036e-01 0.245 0 0
Ribosome-associated quality control R-HSA-9948299 5.718834e-01 0.243 0 0
Signaling by Hedgehog R-HSA-5358351 5.718834e-01 0.243 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.745170e-01 0.241 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.745170e-01 0.241 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.745170e-01 0.241 0 0
MAP kinase activation R-HSA-450294 5.745170e-01 0.241 0 0
Mitochondrial protein import R-HSA-1268020 5.797653e-01 0.237 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.797653e-01 0.237 0 0
Signaling by PDGF R-HSA-186797 5.797653e-01 0.237 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.797653e-01 0.237 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.849491e-01 0.233 0 0
Insulin receptor signalling cascade R-HSA-74751 5.900693e-01 0.229 0 0
IGF1R signaling cascade R-HSA-2428924 5.900693e-01 0.229 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.951267e-01 0.225 0 0
Cellular response to hypoxia R-HSA-1234174 5.951267e-01 0.225 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 5.956982e-01 0.225 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.025770e-01 0.220 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.050559e-01 0.218 0 0
Kidney development R-HSA-9830369 6.050559e-01 0.218 0 0
Transcription of the HIV genome R-HSA-167172 6.099293e-01 0.215 0 0
Gastrulation R-HSA-9758941 6.124345e-01 0.213 0 0
Metabolism of nucleotides R-HSA-15869 6.144280e-01 0.212 0 0
MITF-M-dependent gene expression R-HSA-9856651 6.156788e-01 0.211 0 0
Cell surface interactions at the vascular wall R-HSA-202733 6.170559e-01 0.210 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.194972e-01 0.208 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.194972e-01 0.208 0 0
Interleukin-17 signaling R-HSA-448424 6.194972e-01 0.208 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.194972e-01 0.208 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 6.221052e-01 0.206 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 6.221052e-01 0.206 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.241933e-01 0.205 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.241933e-01 0.205 0 0
Hedgehog 'on' state R-HSA-5632684 6.241933e-01 0.205 0 0
Metabolism of cofactors R-HSA-8978934 6.241933e-01 0.205 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.288317e-01 0.201 0 0
PPARA activates gene expression R-HSA-1989781 6.315898e-01 0.200 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.334131e-01 0.198 0 0
Ca2+ pathway R-HSA-4086398 6.334131e-01 0.198 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 6.334131e-01 0.198 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 6.378097e-01 0.195 0 0
Signaling by FGFR in disease R-HSA-1226099 6.379382e-01 0.195 0 0
ISG15 antiviral mechanism R-HSA-1169408 6.424078e-01 0.192 0 0
Iron uptake and transport R-HSA-917937 6.424078e-01 0.192 0 0
Signaling by NOTCH1 R-HSA-1980143 6.468225e-01 0.189 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.511829e-01 0.186 0 0
Translation of Structural Proteins R-HSA-9694635 6.511829e-01 0.186 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.554898e-01 0.183 0 0
ABC transporter disorders R-HSA-5619084 6.554898e-01 0.183 0 0
G alpha (12/13) signalling events R-HSA-416482 6.554898e-01 0.183 0 0
Cholesterol biosynthesis R-HSA-191273 6.554898e-01 0.183 0 0
PCP/CE pathway R-HSA-4086400 6.554898e-01 0.183 0 0
Selenoamino acid metabolism R-HSA-2408522 6.589338e-01 0.181 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.639454e-01 0.178 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.639454e-01 0.178 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.762432e-01 0.170 0 0
G alpha (s) signalling events R-HSA-418555 6.818610e-01 0.166 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.841919e-01 0.165 0 0
Metabolism of proteins R-HSA-392499 6.855780e-01 0.164 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.880931e-01 0.162 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.919464e-01 0.160 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 6.919464e-01 0.160 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.957523e-01 0.158 0 0
ER-Phagosome pathway R-HSA-1236974 7.032244e-01 0.153 0 0
Neurotransmitter release cycle R-HSA-112310 7.068916e-01 0.151 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.105138e-01 0.148 0 0
Signaling by Insulin receptor R-HSA-74752 7.176251e-01 0.144 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.176251e-01 0.144 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.176251e-01 0.144 0 0
Mitochondrial protein degradation R-HSA-9837999 7.245625e-01 0.140 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.313303e-01 0.136 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 7.346519e-01 0.134 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.411731e-01 0.130 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.411731e-01 0.130 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.411731e-01 0.130 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.411731e-01 0.130 0 0
Interleukin-1 signaling R-HSA-9020702 7.506570e-01 0.125 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 7.597950e-01 0.119 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.657012e-01 0.116 0 0
Post-translational protein modification R-HSA-597592 7.713150e-01 0.113 0 0
Synthesis of DNA R-HSA-69239 7.714628e-01 0.113 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.742905e-01 0.111 0 0
Antigen processing-Cross presentation R-HSA-1236975 7.742905e-01 0.111 0 0
Stimuli-sensing channels R-HSA-2672351 7.742905e-01 0.111 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.770834e-01 0.110 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.798420e-01 0.108 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.798420e-01 0.108 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.879154e-01 0.104 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.931333e-01 0.101 0 0
Drug ADME R-HSA-9748784 7.941334e-01 0.100 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.956942e-01 0.099 0 0
Rab regulation of trafficking R-HSA-9007101 8.031891e-01 0.095 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 8.080330e-01 0.093 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 8.080330e-01 0.093 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 8.127583e-01 0.090 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.150774e-01 0.089 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.150774e-01 0.089 0 0
G1/S Transition R-HSA-69206 8.240714e-01 0.084 0 0
Circadian clock R-HSA-9909396 8.407743e-01 0.075 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.558986e-01 0.068 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.662958e-01 0.062 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.728091e-01 0.059 0 0
S Phase R-HSA-69242 8.728091e-01 0.059 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 8.759463e-01 0.058 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.774859e-01 0.057 0 0
Interleukin-1 family signaling R-HSA-446652 8.790065e-01 0.056 0 0
Regulation of TP53 Activity R-HSA-5633007 8.905144e-01 0.050 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 9.103642e-01 0.041 0 0
Respiratory electron transport R-HSA-611105 9.136658e-01 0.039 0 0
Ion channel transport R-HSA-983712 9.247695e-01 0.034 0 0
Toll-like Receptor Cascades R-HSA-168898 9.266299e-01 0.033 0 0
Metabolism of steroids R-HSA-8957322 9.272871e-01 0.033 0 0
Neddylation R-HSA-8951664 9.502516e-01 0.022 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.641077e-01 0.016 0 0
Cellular response to chemical stress R-HSA-9711123 9.724375e-01 0.012 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.756973e-01 0.011 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.768912e-01 0.010 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.917945e-01 0.004 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.936310e-01 0.003 0 0
G alpha (i) signalling events R-HSA-418594 9.953027e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.961175e-01 0.002 0 0
Diseases of metabolism R-HSA-5668914 9.963566e-01 0.002 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.970794e-01 0.001 0 0
GPCR downstream signalling R-HSA-388396 9.972856e-01 0.001 0 0
Signaling by GPCR R-HSA-372790 9.988870e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.989287e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999602e-01 0.000 0 0
Sensory Perception R-HSA-9709957 9.999983e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 9.999999e-01 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
Interleukin-6 signaling R-HSA-1059683 1.000000e+00 0.000 1 1
MAPK3 (ERK1) activation R-HSA-110056 1.000000e+00 0.000 1 1
RAF-independent MAPK1/3 activation R-HSA-112409 1.000000e+00 0.000 1 0
MAPK1 (ERK2) activation R-HSA-112411 1.000000e+00 0.000 1 1
Other interleukin signaling R-HSA-449836 1.000000e+00 0.000 1 1
Interleukin-6 family signaling R-HSA-6783589 1.000000e+00 0.000 1 0
Interleukin-10 signaling R-HSA-6783783 1.000000e+00 0.000 1 1
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 1.000000e+00 0.000 1 1
Interleukin-20 family signaling R-HSA-8854691 1.000000e+00 0.000 1 1
Interleukin-35 Signalling R-HSA-8984722 1.000000e+00 0.000 1 1
Interleukin-23 signaling R-HSA-9020933 1.000000e+00 0.000 1 1
Interleukin-27 signaling R-HSA-9020956 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways