MARK3

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 S1065 Sugiyama POTEF A26C1B ILASLSTFQQMWISKQEyDEsGPsIVHRKCL__________
O00468 S641 Sugiyama AGRN AGRIN PRCEHPPPGPVCGSDGVTyGsACELREAACLQQtQIEEARA
O14639 S452 Sugiyama ABLIM1 ABLIM KIAA0059 LIMAB1 PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14910 S135 Sugiyama LIN7A MALS1 VELI1 DEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLKRGDQL
O14910 Y133 Sugiyama LIN7A MALS1 VELI1 KTDEGLGFNVMGGKEQNsPIyIsRIIPGGVAERHGGLKRGD
O14974 S445 Sugiyama PPP1R12A MBS MYPT1 EEERKDEsPATWRLGLRKtGsyGALAEItASKEGQKEKDTA
O14974 S910 Sugiyama PPP1R12A MBS MYPT1 yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14980 S1055 Sugiyama XPO1 CRM1 LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O43399 S96 Sugiyama TPD52L2 ELKRRLGLstLGELKQNLsRsWHDVQVssAyVKTSEKLGEW
O43707 S507 Sugiyama ACTN4 DsHNVNtRCQKICDQWDALGsLtHsRREALEKTEKQLEAID
O43707 S511 Sugiyama ACTN4 VNtRCQKICDQWDALGsLtHsRREALEKTEKQLEAIDQLHL
O43707 S763 Sugiyama ACTN4 IARTINEVENQILtRDAKGIsQEQMQEFRASFNHFDKDHGG
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852 S69 Sugiyama CALU HDAFLGAEEAKtFDQLtPEEsKERLGKIVSKIDGDKDGFVt
O60291 S515 Sugiyama MGRN1 KIAA0544 RNF156 sFItEEVDESssPQQGTRAAsIENVLQDssPEHCGRGPPAD
O60333 S1057 Sugiyama KIF1B KIAA0591 KIAA1448 DNEYFNQSDFSSVAMTRsGLsLEELRIVEGQGQSSEVItPP
O60341 S126 Sugiyama KDM1A AOF2 KDM1 KIAA0601 LSD1 EGRRTsRRKRAKVEyREMDEsLANLsEDEyysEEERNAKAE
O60716 S230 Sugiyama CTNND1 KIAA0384 PDGysRHyEDGyPGGsDNyGsLsRVtRIEERyRPsMEGyRA
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O60749 S119 Sugiyama SNX2 TRG9 AVtPVtPttLIAPRIESKsMsAPVIFDRsREEIEEEANGDI
O75122 S327 Sugiyama CLASP2 KIAA0627 YLKssGsVAsLPQsDRsssssQEsLNRPFSSKWSTANPSTV
O75179 S243 Sugiyama ANKRD17 GTAR KIAA0697 RAEStANAGQSDNRSLAEACsEGDVNAVRKLLIEGRSVNEH
O75390 S453 Sugiyama CS LAQLIWSRALGFPLERPKSMsTEGLMKFVDSKSG_______
O75489 S110 Sugiyama NDUFS3 PDGVIPVLTFLRDHTNAQFKsLVDLTAVDVPTRQNRFEIVY
O75822 S127 Sugiyama EIF3J EIF3S1 PRO0391 VLtPEEQLADKLRLKKLQEEsDLELAKEtFGVNNAVyGIDA
O75822 S202 Sugiyama EIF3J EIF3S1 PRO0391 VLVRDVCISLEIDDLKKITNsLTVLCsEKQKQEKQSKAKKK
O94874 S778 Sugiyama UFL1 KIAA0776 MAXER NLBP RCAD DKEQEDVASTTRKELQELSssIKDLVLKSRKSsVTEE____
O95155 S105 Sugiyama UBE4B HDNB1 KIAA0684 UFD2 LsssPsNsLEtQsQsLsRsQsMDIDGVSCEKsMsQVDVDsG
O95218 S181 Sugiyama ZRANB2 ZIS ZNF265 DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR
O95819 S800 Sugiyama MAP4K4 HGK KIAA0687 NIK DVEQEGADESTSGPEDTRAAsSLNLSNGETESVKTMIVHDD
P00338 S105 Sugiyama LDHA PIG19 VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00491 S176 Sugiyama PNP NP GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00558 S174 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558 S175 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04083 S201 Sugiyama ANXA1 ANX1 LPC1 LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S187 Sugiyama HSPB1 HSP27 HSP28 APMPKLAtQsNEItIPVtFEsRAQLGGPEAAKsDETAAK__
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05023 S520 Sugiyama ATP1A1 EPQHLLVMKGAPERILDRCssILLHGKEQPLDEELKDAFQN
P05198 S219 Sugiyama EIF2S1 EIF2A CYGYEGIDAVKEALRAGLNCsTENMPIKINLIAPPRYVMTT
P05783 S305 Sugiyama KRT18 CYK18 PIG46 QSAEVGAAETTLTELRRtVQsLEIDLDsMRNLKAsLENsLR
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P07195 S106 Sugiyama LDHB VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07339 S42 Sugiyama CTSD CPSD VRIPLHKFTSIRRtMsEVGGsVEDLIAKGPVSKYSQAVPAV
P07384 S474 Sugiyama CAPN1 CANPL1 PIG30 GQPAVHLKRDFFLANAsRARsEQFINLREVSTRFRLPPGEY
P07437 S115 Sugiyama TUBB TUBB5 OK/SW-cl.56 sGAGNNWAKGHytEGAELVDsVLDVVRKEAESCDCLQGFQL
P07437 S40 Sugiyama TUBB TUBB5 OK/SW-cl.56 FWEVISDEHGIDPTGtyHGDsDLQLDRIsVyyNEAtGGKyV
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07814 S747 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 ETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVREL
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S165 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900 S169 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA TVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTKVILH
P07900 S399 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 S63 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P07900 Y61 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA KEIFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLI
P08195 S286 Sugiyama SLC3A2 MDU1 KNQKDDVAQtDLLQIDPNFGsKEDFDsLLQsAKKKSIRVIL
P08238 S160 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238 S164 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB VVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTKVILH
P08238 S391 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 S532 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB yMtEPIDEyCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKK
P08238 S58 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238 Y56 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEIFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDII
P09382 S63 Sugiyama LGALS1 CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09923 S189 Sugiyama ALPI RVQHAsPAGtyAHtVNRNWysDADMPASARQEGCQDIATQL
P0CG38 S1065 Sugiyama POTEI ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P0CG39 S1028 Sugiyama POTEJ ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
P10398 S157 Sugiyama ARAF ARAF1 PKS PKS2 SSKVPTVCVDMSTNRQQFyHsVQDLsGGsRQHEAPsNRPLN
P10809 S488 Sugiyama HSPD1 HSP60 IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11279 S141 Sugiyama LAMP1 NLSDTHLFPNASSKEIKtVEsITDIRADIDKKYRCVSGTQV
P11586 S765 Sugiyama MTHFD1 MTHFC MTHFD ARMFGIPVVVAVNAFKTDTEsELDLIsRLSREHGAFDAVKC
P12004 S172 Sugiyama PCNA sHIGDAVVIsCAKDGVKFSAsGELGNGNIKLSQTSNVDKEE
P12268 S416 Sugiyama IMPDH2 IMPD2 APGEYFFSDGIRLKKyRGMGsLDAMDKHLssQNRyFsEADK
P12814 S744 Sugiyama ACTN1 IARTINEVENQILtRDAKGIsQEQMNEFRAsFNHFDRDHsG
P13473 S155 Sugiyama LAMP2 LTVDELLAIRIPLNDLFRCNsLSTLEKNDVVQHYWDVLVQA
P13489 S178 Sugiyama RNH1 PRI RNH SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP
P13639 S23 Sugiyama EEF2 EF2 NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13639 S38 Sugiyama EEF2 EF2 NIRNMsVIAHVDHGKStLtDsLVCKAGIIAsARAGEtRFtD
P13639 S732 Sugiyama EEF2 EF2 DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13667 S468 Sugiyama PDIA4 ERP70 ERP72 ytFAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAM
P13667 S470 Sugiyama PDIA4 ERP70 ERP72 FAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAMEP
P13797 S540 Sugiyama PLS3 NDDIIVNWVNRTLSEAGKSTsIQSFKDKTISSSLAVVDLID
P13798 S187 Sugiyama APEH D3F15S2 D3S48E DNF15S2 EKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQFV
P13798 S27 Sugiyama APEH D3F15S2 D3S48E DNF15S2 LsEPEEAAALyRGLSRQPALsAACLGPEVtTQyGGQyRTVH
P13861 S395 Sugiyama PRKAR2A PKR2 PRKAR2 MDIMKRNIsHYEEQLVKMFGssVDLGNLGQ___________
P14618 S100 Sugiyama PKM OIP3 PK2 PK3 PKM2 tHEyHAEtIKNVRtAtEsFAsDPILyRPVAVALDTKGPEIR
P14618 S205 Sugiyama PKM OIP3 PK2 PK3 PKM2 VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S447 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 PKyLNFVKGVVDsDDLPLNVsREtLQQHKLLKVIRKKLVRK
P14625 T171 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15531 S122 Sugiyama NME1 NDPKA NM23 GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P18615 S115 Sugiyama NELFE RD RDBP KLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLyEs
P18615 S139 Sugiyama NELFE RD RDBP DLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEGPGAG
P18669 S14 Sugiyama PGAM1 PGAMA CDABP0006 _______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG
P18669 S155 Sugiyama PGAM1 PGAMA CDABP0006 NIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQI
P18754 S85 Sugiyama RCC1 CHC1 IPEDVVQAEAGGMHTVCLSKsGQVysFGCNDEGALGRDtsV
P19338 S356 Sugiyama NCL LAVVDVRIGMTRKFGyVDFEsAEDLEKALELtGLKVFGNEI
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P20618 S157 Sugiyama PSMB1 PSC5 IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P20674 S104 Sugiyama COX5A PEPKIIDAALRACRRLNDFAstVRILEVVKDKAGPHKEIYP
P21108 S11 Sugiyama PRPS1L1 PRPS3 PRPSL __________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P21333 S2152 Sugiyama FLNA FLN FLN1 VKVTGEGRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQ
P21333 S2158 Sugiyama FLNA FLN FLN1 GRVKEsITRRRRAPsVANVGsHCDLsLKIPEIsIQDMtAQV
P22314 S46 Sugiyama UBA1 A1S9T UBE1 AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S324 Sugiyama HNRNPA2B1 HNRPA2B1 GNYNQQPSNYGPMKsGNFGGsRNMGGPyGGGNyGPGGsGGs
P23284 S150 Sugiyama PPIB CYPB LKHyGPGWVsMANAGKDTNGsQFFITTVKTAWLDGKHVVFG
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P24534 S174 Sugiyama EEF1B2 EEF1B EF1B DMAKLEECVRsIQADGLVWGssKLVPVGyGIKKLQIQCVVE
P24539 S142 Sugiyama ATP5PB ATP5F1 DFADKLNEQKLAQLEEAKQAsIQHIQNAIDTEKsQQALVQK
P25054 S1389 Sugiyama APC DP2.5 PKsPPEHYVQETPLMFsRCTsVSsLDSFESRSIASSVQSEP
P25054 S1861 Sugiyama APC DP2.5 DsPHHytPIEGTPYCFsRNDsLssLDFDDDDVDLSREKAEL
P25705 S76 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM EERILGADtsVDLEETGRVLsIGDGIARVHGLRNVQAEEMV
P26038 T465 Sugiyama MSN WQQKAQMVQEDLEKTRAELKtAMstPHVAEPAENEQDEQDE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T107 Sugiyama RPL13 BBC1 OK/SW-cl.46 HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF
P27448 S400 Sugiyama MARK3 CTAK1 EMK2 sNLsLAKVRPssDLNNSTGQsPHHKVQRSVSSSQKQRRYSD
P27448 S42 Sugiyama MARK3 CTAK1 EMK2 GDGRQEVTSRTSRSGARCRNsIAsCADEQPHIGNyRLLKTI
P27448 S45 Sugiyama MARK3 CTAK1 EMK2 RQEVTSRTSRSGARCRNsIAsCADEQPHIGNyRLLKTIGKG
P27448 S451 Sugiyama MARK3 CTAK1 EMK2 AYPKRsQtstADSDLKEDGIsSRKSSGSAVGGKGIAPAsPM
P27448 S499 Sugiyama MARK3 CTAK1 EMK2 NKADIPERKKsstVPSSNTAsGGMTRRNtYVCSERTTADRH
P27448 S563 Sugiyama MARK3 CTAK1 EMK2 sIssAAtPDRIRFPRGtASRstFHGQPRERRtAtYNGPPAs
P27448 S598 PSP MARK3 CTAK1 EMK2 NGPPAsPsLsHEAtPLsQtRsRGstNLFsKLTsKLTRRNMS
P27448 S601 PSP MARK3 CTAK1 EMK2 PAsPsLsHEAtPLsQtRsRGstNLFsKLTsKLTRRNMSFRF
P27448 S606 PSP|Sugiyama MARK3 CTAK1 EMK2 LsHEAtPLsQtRsRGstNLFsKLTsKLTRRNMSFRFIKRLP
P27448 S610 Sugiyama MARK3 CTAK1 EMK2 AtPLsQtRsRGstNLFsKLTsKLTRRNMSFRFIKRLPTEYE
P27448 T559 Sugiyama MARK3 CTAK1 EMK2 AstHsIssAAtPDRIRFPRGtASRstFHGQPRERRtAtYNG
P27448 T564 Sugiyama MARK3 CTAK1 EMK2 IssAAtPDRIRFPRGtASRstFHGQPRERRtAtYNGPPAsP
P27448 T602 PSP MARK3 CTAK1 EMK2 AsPsLsHEAtPLsQtRsRGstNLFsKLTsKLTRRNMSFRFI
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P28838 S180 Sugiyama LAP3 LAPEP PEPS YEYDDLKQKKKMAVSAKLyGsGDQEAWQKGVLFAsGQNLAR
P28838 S194 Sugiyama LAP3 LAPEP PEPS SAKLyGsGDQEAWQKGVLFAsGQNLARQLMETPANEMTPtR
P29401 S105 Sugiyama TKT VWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGsL
P29401 S443 Sugiyama TKT EDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAAN
P29401 T442 Sugiyama TKT GEDGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAA
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30307 S216 GPS6|SIGNOR|iPTMNet|EPSD|PSP CDC25C EFsLKDQEAKVSRsGLYRsPsMPENLNRPRLKQVEKFKDNt
P30622 S195 Sugiyama CLIP1 CYLN1 RSN AAKEPsAtPPISNLTKtAsEsIsNLsEAGsIKKGERELKIG
P31327 S537 Sugiyama CPS1 GVELFKRGVLKEYGVKVLGtsVEsIMATEDRQLFSDKLNEI
P31327 S835 Sugiyama CPS1 MCHPsIEGFTPRLPMNKEWPsNLDLRKELSEPSsTRIyAIA
P34897 S81 Sugiyama SHMT2 QREKDRQCRGLELIAsENFCsRAALEALGsCLNNKYSEGYP
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P35606 S350 Sugiyama COPB2 MGDAEIKDGERLPLAVKDMGsCEIyPQtIQHNPNGRFVVVC
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802 S185 Sugiyama TAGLN2 KIAA0120 CDABP0035 NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P41236 S72 EPSD|PSP PPP1R2 IPP2 ILAtyHPADKDyGLMKIDEPstPYHsMMGDDEDACsDtEAt
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 S1098 Sugiyama MKI67 PAARVTGMKKWPRtPKEEAQsLEDLAGFKELFQtPGPsEEs
P46013 S651 Sugiyama MKI67 ISRsQHDILQMICSKRRsGAsEANLIVAKSWADVVKLGAKQ
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46940 S482 Sugiyama IQGAP1 KIAA0051 LINRALESGDVNTVWKQLsssVtGLTNIEEENCQRYLDELM
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321 S659 Sugiyama NASP IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst
P49327 S265 Sugiyama FASN FAS TILNAGTNTDGFKEQGVtFPsGDIQEQLIRSLyQsAGVAPE
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49368 S458 Sugiyama CCT3 CCTG TRIC5 RAVAQALEVIPRTLIQNCGAstIRLLtSLRAKHtQENCEtW
P49589 S307 Sugiyama CARS1 CARS VPEAVGDQKALQEGEGDLsIsADRLsEKRSPNDFALWKASK
P49589 S312 Sugiyama CARS1 CARS GDQKALQEGEGDLsIsADRLsEKRSPNDFALWKASKPGEPS
P49736 S170 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 KRRQVERAtEDGEEDEEMIEsIENLEDLKGHSVREWVsMAG
P50395 S396 Sugiyama GDI2 RABGDIB IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50402 T30 Sugiyama EMD EDMD STA tELttLLRRyNIPHGPVVGstRRLyEKKIFEyEtQRRRLsP
P50990 S380 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 VVVFKHEKEDGAIstIVLRGstDNLMDDIERAVDDGVNtFK
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52597 S63 Sugiyama HNRNPF HNRPF VHFIYTREGRQsGEAFVELGsEDDVKMALKKDRESMGHRyI
P53621 S389 Sugiyama COPA SYNPAENAVLLCTRAsNLENstyDLytIPKDADsQNPDAPE
P53999 S58 Sugiyama SUB1 PC4 RPO2TC1 KKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRDFK
P54105 S42 Sugiyama CLNS1A CLCI ICLN DTEAVLNGKGLGtGtLyIAEsRLSWLDGsGLGFSLEYPTIS
P54252 S260 Sugiyama ATXN3 ATX3 MJD MJD1 SCA3 IDMEDEEADLRRAIQLsMQGssRNIsQDMtQtsGTNLTSEE
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55036 S266 Sugiyama PSMD4 MCB1 AGIATTGtEDsDDALLKMtIsQQEFGRTGLPDLSSMTEEEQ
P55769 S122 Sugiyama SNU13 NHP2L1 CSVTIKEGSQLKQQIQsIQQsIERLLV______________
P55957 S78 Sugiyama BID QtDGNRssHsRLGRIEADsEsQEDIIRNIARHLAQVGDsMD
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S365 Sugiyama ACTB ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60891 S11 Sugiyama PRPS1 __________MPNIKIFsGssHQDLSQKIADRLGLELGKVV
P61081 S175 Sugiyama UBE2M UBC12 NNRRLFEQNVQRSMRGGyIGstyFERCLK____________
P61163 T248 Sugiyama ACTR1A CTRN1 PQKDETLETEKAQyyLPDGstIEIGPSRFRAPELLFRPDLI
P61313 S97 Sugiyama RPL15 EC45 TCBAP0781 KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61916 S29 Sugiyama NPC2 HE1 LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S156 Sugiyama YWHAE AtGNDRKEAAENsLVAyKAAsDIAMtELPPTHPIRLGLALN
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63220 S65 Sugiyama RPS21 RFNGQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF__
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S365 Sugiyama ACTG1 ACTG ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P78371 S470 Sugiyama CCT2 99D8.1 CCTB IADNAGYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAI
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00610 S1462 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 VKQLPLVKPYLRSVQNHNNKsVNEsLNNLFITEEDyQALRT
Q00613 S375 Sugiyama HSF1 HSTF1 TDtEGRPPsPPPtstPEKCLsVACLDKNELSDHLDAMDSNL
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01082 T1386 Sugiyama SPTBN1 SPTB2 ESTTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSD
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01650 S31 Sugiyama SLC7A5 CD98LC LAT1 MPE16 LAAPAAEEKEEAREKMLAAKsADGsAPAGEGEGVtLQRNIT
Q02878 S255 Sugiyama RPL6 TXREB1 tEKEKYEITEQRKIDQKAVDsQILPKIKAIPQLQGYLRSVF
Q04637 S1238 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI RDAVKREAALPPVsPLKAALsEEELEKKsKAIIEEyLHLND
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06413 S222 EPSD|PSP MEF2C GDLTSGAGTSAGNGYGNPRNsPGLLVsPGNLNKNMQAKsPP
Q07021 S164 Sugiyama C1QBP GC1QBP HABP1 SF2P32 DGEEEPSQGQKVEEQEPELtstPNFVVEVIKNDDGKKALVL
Q07021 T165 Sugiyama C1QBP GC1QBP HABP1 SF2P32 GEEEPSQGQKVEEQEPELtstPNFVVEVIKNDDGKKALVLD
Q08378 S497 Sugiyama GOLGA3 CWDLERAMTDLQNMLEAKNAsLAssNNDLQVAEEQyQRLMA
Q08AD1 S464 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 FDKEDSVQRstPNRGITRsIsNEGLtLNNsHVsKHIRKNLS
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q09028 S147 Sugiyama RBBP4 RBAP48 VNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGEC
Q09666 S216 Sugiyama AHNAK PM227 DVEtQsGKtVIRLPsGsGAAsPtGsAVDIRAGAIsAsGPEL
Q12802 S1929 Sugiyama AKAP13 BRX HT31 LBC NITGVGNDENMSNTWKFLsHstDsLNKISKVNEstEsLtDE
Q13098 S485 Sugiyama GPS1 COPS1 CSN1 HVKsPPREGsQGELtPANsQsRMstNM______________
Q13136 S338 Sugiyama PPFIA1 LIP1 MEERITTLEKRYLAAQREATsVHDLNDKLENEIANKDSMHR
Q13136 S668 Sugiyama PPFIA1 LIP1 EEKENTEQRAEEIESRVGsGsLDNLGRFRSMssIPPYPAss
Q13200 S147 Sugiyama PSMD2 TRAP2 SVLAMTMSGERECLKYRLVGsQEELASWGHEYVRHLAGEVA
Q13243 S153 Sugiyama SRSF5 HRS SFRS5 SRP40 EVTFADAHRPKLNEGVVEFAsYGDLKNAIEKLSGKEINGRK
Q13263 S784 Sugiyama TRIM28 KAP1 RNF96 TIF1B DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13283 S362 Sugiyama G3BP1 G3BP LFIGNLPHEVDKSELKDFFQsyGNVVELRINsGGKLPNFGF
Q13347 S217 Sugiyama EIF3I EIF3S2 TRIP1 sRDMtMFVtASKDNTAKLFDsttLEHQKTFRTERPVNSAAL
Q13470 S502 SIGNOR|PSP TNK1 PPARGQRRNMPLERMKGIsRsLEsVLsLGPRPtGGGssPPE
Q13509 S115 Sugiyama TUBB3 TUBB4 SGAGNNWAKGHytEGAELVDsVLDVVRKECENCDCLQGFQL
Q13625 S480 Sugiyama TP53BP2 ASPP2 BBP FDAVDQSNAPPSFGTLRKNQssEDILRDAQVANKNVAKVPP
Q13885 S115 Sugiyama TUBB2A TUBB2 sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q14152 S492 Sugiyama EIF3A EIF3S10 KIAA0139 VDAARHCDLQVRIDHTSRTLsFGsDLNyAtREDAPIGPHLQ
Q14192 S238 Sugiyama FHL2 DRAL SLIM3 AKKCAGCTNPISGLGGtKyIsFEERQWHNDCFNCKKCsLsL
Q14258 S340 Sugiyama TRIM25 EFP RNF147 ZNF147 KPVYIPEVELNHKLIKGIHQstIDLKNELKQCIGRLQEPTP
Q14258 T341 Sugiyama TRIM25 EFP RNF147 ZNF147 PVYIPEVELNHKLIKGIHQstIDLKNELKQCIGRLQEPTPS
Q14498 S336 Sugiyama RBM39 HCC1 RNPC2 LAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGR
Q14568 S165 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568 S169 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 TVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTKVILH
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14738 S598 Sugiyama PPP2R5D DVyTIKALEAHKRAEEFLTAsQEAL________________
Q14980 S1181 Sugiyama NUMA1 NMP22 NUMA DsALEtLQGQLEEKAQELGHsQsALAsAQRELAAFRTKVQD
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15185 S85 Sugiyama PTGES3 P23 TEBP KHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVDFNN
Q15276 S407 Sugiyama RABEP1 RAB5EP RABPT5 RABPT5A GDPFSKSDNDMFKDGLRRAQstDsLGtsGsLQSKALGYNYK
Q15293 S80 Sugiyama RCN1 RCN HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt
Q15642 S296 Sugiyama TRIP10 CIP4 STOT STP FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15818 S91 Sugiyama NPTX1 TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP
Q16204 S325 Sugiyama CCDC6 D10S170 TST1 QRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQGL
Q16513 S583 Sugiyama PKN2 PRK2 PRKCL2 VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16531 T1125 Sugiyama DDB1 XAP1 MQEVVANLQYDDGSGMKREAtADDLIKVVEELtRIH_____
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q16576 S146 Sugiyama RBBP7 RBAP46 VNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGEC
Q16719 S443 Sugiyama KYNU VVCDKRNPNGIRVAPVPLyNsFHDVyKFTNLLtsILDsAET
Q16836 S196 Sugiyama HADH HAD HAD1 HADHSC SCHAD PVMKLVEVIKTPMTSQKTFEsLVDFSKALGKHPVSCKDTPG
Q3MII6 S506 Sugiyama TBC1D25 OATL1 DHLATASQGPGGGGRLLRQAsLDGLQQLRDNMGSRRDPLVQ
Q3V6T2 S1702 Sugiyama CCDC88A APE GRDN KIAA1212 TLQQFLEEsNKLTSVQIKsssQENLLDEVMKSLsVssDFLG
Q53EL6 S46 Sugiyama PDCD4 H731 GDEENAGTEEIKNEINGNWIsAssINEARINAKAKRRLRKN
Q58FF6 S34 Sugiyama HSP90AB4P IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF6 Y32 Sugiyama HSP90AB4P KEIFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDII
Q58FF7 S405 Sugiyama HSP90AB3P HSP90BC YMTEPIDEYCVQQLKEFDGKsLVsVtKEGLELPEDEEEKKK
Q58FF7 S58 Sugiyama HSP90AB3P HSP90BC IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF7 Y56 Sugiyama HSP90AB3P HSP90BC EEIFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDII
Q58FF8 S305 Sugiyama HSP90AB2P HSP90BB RVVYMTEPIDGYQLKEFDGKsLVsVtKEGLELPEDGEEKKR
Q58FF8 S58 Sugiyama HSP90AB2P HSP90BB IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8 Y56 Sugiyama HSP90AB2P HSP90BB KEIFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDII
Q5JSH3 S565 Sugiyama WDR44 RPH11 DYFNNMRMKYNtEGRVsPsPsQEsLsssKsDTDtGVCsGtD
Q5T035 T62 Sugiyama FAM120A2P C9orf129 yPysLSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyER
Q5VT52 S1070 Sugiyama RPRD2 KIAA0460 HSPC099 TATDQQQQEEHYRIETRVsssCLDLPDSTEEKGAPIETLGy
Q6FI81 S305 Sugiyama CIAPIN1 CUA001 PRO0915 CAsCPyLGMPAFKPGEKVLLsDsNLHDA_____________
Q6P1J9 S178 Sugiyama CDC73 C1orf28 HRPT2 EGHKEGIVQTEQIRSLsEAMsVEKIAAIKAKIMAKKRSTIK
Q6PID6 S19 Sugiyama TTC33 __MASFGWKRKIGEKVSKVTsQQFEAEAADEKDVVDNDEGN
Q6S8J3 S1065 Sugiyama POTEE A26C1A POTE2 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q7Z2W4 S492 Sugiyama ZC3HAV1 ZC3HDC2 PRO1677 VQATGRIADDADPRVALVNDsLsDVtsTtssRVDDHDSEEI
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z417 S655 Sugiyama NUFIP2 KIAA1321 PIG1 LGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsIWNL
Q7Z417 S671 Sugiyama NUFIP2 KIAA1321 PIG1 DsWGsFDLRAAIVYHTKEMEsIWNLQKQDPKRIItyNEAMD
Q7Z460 S1196 Sugiyama CLASP1 KIAA0622 MAST1 EEIYSSLRGVTEAIEKFsFRsQEDLNEPIKRDGKKECDIVs
Q7Z460 S545 Sugiyama CLASP1 KIAA0622 MAST1 yHTLESSyQKALQSHLKNSDsIVsLPQsDRsssssQEsLNR
Q86TC9 S197 Sugiyama MYPN MYOP ACKNHKSKLESQNKVMQENSssFsDLSERRERSSVPIPIPA
Q86TC9 S198 Sugiyama MYPN MYOP CKNHKSKLESQNKVMQENSssFsDLSERRERSSVPIPIPAD
Q86V81 S239 Sugiyama ALYREF ALY BEF THOC4 tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86VQ1 S226 Sugiyama GLCCI1 sCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQRSKQ
Q8IUD2 S824 Sugiyama ERC1 ELKS KIAA1081 RAB6IP2 KKKsAQMLEEARRREDNLNDsSQQLQDSLRKKDDRIEELEE
Q8IYB3 S240 Sugiyama SRRM1 SRM160 tPELPEPsVKVKEPsVQEAtstsDILKVPKPEPIPEPKEPs
Q8IZP0 S22 Sugiyama ABI1 SSH3BP1 AELQMLLEEEIPSGKRALIEsyQNLTRVADyCENNyIQATD
Q8IZU2 S124 Sugiyama WDR17 TDNLVIIWNVAEQKVIAKLDstKGIPASLSWCWNAEDVVAF
Q8IZU2 T125 Sugiyama WDR17 DNLVIIWNVAEQKVIAKLDstKGIPASLSWCWNAEDVVAFV
Q8WU90 S351 Sugiyama ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730 DIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLsEAs
Q8WWI1 S706 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 RLMVERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQK
Q8WWI1 S709 Sugiyama LMO7 FBX20 FBXO20 KIAA0858 VERLFQKIYGENGsKsMsDVsAEDVQNLRQLRYEEMQKIKS
Q8WXH0 S2781 Sugiyama SYNE2 KIAA1011 NUA ILSQIRKCKVTHDGILARQQsVEsLAEEVKDKVPSLTTYEG
Q92609 S541 Sugiyama TBC1D5 KIAA0210 EsMPVQLNKGLSSKNIsssPsVEsLPGGREFtGsPPssAtK
Q92974 S151 SIGNOR|EPSD|PSP ARHGEF2 KIAA0651 LFP40 RQsLLGsRRGRssLSLAKsVsttNIAGHFNDEsPLGLRRIL
Q96CT7 S122 Sugiyama CCDC124 DtLRRDHQLREAPDTAEKAKsHLEVPLEENVNRRVLEEGsV
Q96D15 S98 Sugiyama RCN3 UNQ239/PRO272 ARLGRIVDRMDRAGDGDGWVsLAELRAWIAHTQQRHIRDsV
Q96EY7 S651 Sugiyama PTCD3 MRPS39 TRG15 VELASAFSLPICEGLTQRVMsDFAINQEQKEALsNLtALts
Q96JP5 S177 Sugiyama ZFP91 ZNF757 FKSG11 TSVSRHRDTENTRSSRSKTGsLQLICKSEPNTDQLDYDVGE
Q96KP4 S58 Sugiyama CNDP2 CN2 CPGL HEL-S-13 PEPA RGEIRRMMEVAAADVKQLGGsVELVDIGKQKLPDGSEIPLP
Q96N67 S1438 Sugiyama DOCK7 KIAA1771 LGTYTIAsPPERsPsGsAFGsQENLRWRKDMTHWRQNTEKL
Q96PK6 S520 Sugiyama RBM14 SIP AAAAYGAQPSATLAAPYRtQssAsLAAsYAAQQHPQAAASY
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99689 S58 EPSD|PSP FEZ1 LEDPSLSELENFSSEIISFKsMEDLVNEFDEKLNVCFRNYN
Q9BRX5 S85 Sugiyama GINS3 PSF3 KLELPLWLAKGLFDNKRRILsVELPKIyQEGWRTVFSADPN
Q9BVA1 S115 Sugiyama TUBB2B sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q9BYX7 S365 Sugiyama POTEKP ACTBL3 FKSG30 ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________
Q9C0C2 S1158 Sugiyama TNKS1BP1 KIAA1741 TAB182 sPssKMEGGHFVPPGKttAGsVDWTDQLGLRNLEVssCVGs
Q9H0H5 S257 Sugiyama RACGAP1 KIAA1478 MGCRACGAP ETVPYWtRSRRKtGtLQPWNsDstLNSRQLEPRTETDsVGt
Q9H501 S77 Sugiyama ESF1 ABTAP C20orf6 HDCMC28P GRPISHSTTEDLKRFyDLsDsDsNLsGEDSKALSQKKIKKK
Q9H7E9 T40 Sugiyama C8orf33 PCAsRGARLPGPVsSARNPstVCLCPEQPTCSNADSRAHPL
Q9HAP6 S120 Sugiyama LIN7B MALS2 VELI2 UNQ3116/PRO10200 DEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLKRGDQL
Q9HAP6 Y118 Sugiyama LIN7B MALS2 VELI2 UNQ3116/PRO10200 KTDEGLGFNIMGGKEQNsPIyIsRVIPGGVADRHGGLKRGD
Q9HAU0 S410 Sugiyama PLEKHA5 KIAA1686 PEPP2 NRPNTGPLytEADRVIQRtNsMQQLEQWIKIQKGRGHEEET
Q9HCN4 S301 Sugiyama GPN1 MBDIN RPAP4 XAB1 HUSSY-23 ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD
Q9HCN8 S40 Sugiyama SDF2L1 UNQ1941/PRO4424 ALLVPGGGAAKTGAELVTCGsVLKLLNTHHRVRLHSHDIKY
Q9HD42 S101 Sugiyama CHMP1A CHMP1 KIAA0047 PCOLN3 PRSM1 TMKGVTKNMAQVTKALDKALsTMDLQKVSSVMDRFEQQVQN
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NUP9 S120 Sugiyama LIN7C MALS3 VELI3 EEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLKRGDQL
Q9NUP9 Y118 Sugiyama LIN7C MALS3 VELI3 KTEEGLGFNIMGGKEQNsPIyIsRIIPGGIADRHGGLKRGD
Q9NW75 S146 Sugiyama GPATCH2 GPATC2 RRPsSNLNNNVRGKRPLWHEsDFAVDNVGNRTLRRRRKVKR
Q9NYB9 S22 Sugiyama ABI2 ARGBPIA AELQMLLEEEIPGGRRALFDsytNLERVADyCENNyIQSAD
Q9NZB2 T413 Sugiyama FAM120A C9orf10 KIAA0183 OSSA yPysLSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyER
Q9P1Y5 S431 Sugiyama CAMSAP3 KIAA1543 FGLDSDVDVVMGDPVLLRsVssDsLGPPRPAPARTPtQPPP
Q9P265 S203 Sugiyama DIP2B KIAA1463 stsssASSTLSHGEVKGtsGsLADVFANtRIENFSAPPDVT
Q9UBU9 S223 Sugiyama NXF1 TAP ELKPEQVEQLKLIMSKRYDGsQQALDLKGLRSDPDLVAQNI
Q9UI15 S185 Sugiyama TAGLN3 NP25 EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UII2 S63 Sugiyama ATP5IF1 ATPI ATPIF1 AGGAFGKREQAEEERyFRAQsREQLAALKKHHEEEIVHHKK
Q9UJF2 S803 Sugiyama RASAL2 NGAP NPVyHLNNPIPAMPKASIDssLENLSTAssRSQSNSEDFKL
Q9UNF1 S85 Sugiyama MAGED2 BCG1 KAtEVsKtPEAREAPAtQAssttQLtDtQVLAAENKSLAAD
Q9UNZ2 S74 Sugiyama NSFL1C UBXN2C SQATPssVsRGTAPSDNRVtsFRDLIHDQDEDEEEEEGQRF
Q9UQ35 S1539 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sEssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEs
Q9UQ35 S1541 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0 S116 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y3B8 S203 Sugiyama REXO2 SFN SMFN CGI-114 EYEFAPKKAAsHRALDDIsEsIKELQFyRNNIFKKKIDEKK
Q9Y490 S1535 Sugiyama TLN1 KIAA1027 TLN RTTNPTAKRQFVQSAKEVANsTANLVKTIKALDGAFTEENR
Q9Y4G6 S1537 Sugiyama TLN2 KIAA0320 KTANPVAKRHFVQSAKEVANsTANLVKTIKALDGDFSEDNR
Q9Y4L1 S742 Sugiyama HYOU1 GRP170 HSPH4 ORP150 KLQDLTLRDLEKQEREKAANsLEAFIFEtQDKLyQPEyQEV
Q9Y4L1 T750 Sugiyama HYOU1 GRP170 HSPH4 ORP150 DLEKQEREKAANsLEAFIFEtQDKLyQPEyQEVsTEEQREE
Q9Y4W2 S636 Sugiyama LAS1L MSTP060 EsPtAENARLLAQKRGALQGsAWQVssEDVRWDTFPLGRMP
Q9Y4W2 S641 Sugiyama LAS1L MSTP060 ENARLLAQKRGALQGsAWQVssEDVRWDTFPLGRMPGQTED
Q9Y6Y8 T893 Sugiyama SEC23IP MSTP053 GFISSLKSAWQTLNEFARAHtsstQLQEELEKVANQIKEEE
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Mitotic Prometaphase R-HSA-68877 6.154341e-07 6.211 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.686553e-07 6.114 0 0
Signal Transduction R-HSA-162582 1.016568e-06 5.993 1 0
Cell Cycle R-HSA-1640170 1.842840e-06 5.735 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.462069e-06 5.609 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.560319e-06 5.449 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 4.837614e-06 5.315 0 0
Kinesins R-HSA-983189 6.742554e-06 5.171 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.630264e-05 4.788 0 0
Apoptotic execution phase R-HSA-75153 1.586258e-05 4.800 0 0
Cell Cycle, Mitotic R-HSA-69278 1.979853e-05 4.703 0 0
Interleukin-37 signaling R-HSA-9008059 3.372096e-05 4.472 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.609127e-05 4.251 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 6.665651e-05 4.176 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 6.974568e-05 4.156 1 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.009354e-05 4.154 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.693543e-05 4.061 0 0
Apoptosis R-HSA-109581 9.647730e-05 4.016 0 0
Striated Muscle Contraction R-HSA-390522 1.126335e-04 3.948 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.575922e-04 3.802 0 0
PKR-mediated signaling R-HSA-9833482 1.579985e-04 3.801 0 0
M Phase R-HSA-68886 1.477583e-04 3.830 0 0
Recycling pathway of L1 R-HSA-437239 1.773832e-04 3.751 0 0
Muscle contraction R-HSA-397014 1.968023e-04 3.706 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.251417e-04 3.648 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.279509e-04 3.642 0 0
Membrane Trafficking R-HSA-199991 3.051323e-04 3.516 0 0
Programmed Cell Death R-HSA-5357801 3.120200e-04 3.506 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 3.603916e-04 3.443 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.220932e-04 3.375 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.220932e-04 3.375 0 0
Cell Cycle Checkpoints R-HSA-69620 5.109847e-04 3.292 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.760037e-04 3.240 0 0
Signaling by Hippo R-HSA-2028269 8.033197e-04 3.095 0 0
ISG15 antiviral mechanism R-HSA-1169408 8.547455e-04 3.068 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.050675e-03 2.979 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.040718e-03 2.983 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.116481e-03 2.952 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.295883e-03 2.887 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.295883e-03 2.887 0 0
Cellular response to heat stress R-HSA-3371556 1.296243e-03 2.887 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.417035e-03 2.849 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.398659e-03 2.854 0 0
Separation of Sister Chromatids R-HSA-2467813 1.421986e-03 2.847 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.483457e-03 2.829 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.483457e-03 2.829 0 0
Aggrephagy R-HSA-9646399 1.738145e-03 2.760 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.100238e-03 2.678 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.041806e-03 2.690 0 0
Nephrin family interactions R-HSA-373753 2.041806e-03 2.690 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.166339e-03 2.664 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.494668e-03 2.603 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.563940e-03 2.591 1 1
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.521222e-03 2.598 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.701077e-03 2.568 0 0
Death Receptor Signaling R-HSA-73887 2.953555e-03 2.530 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.891471e-03 2.539 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.019913e-03 2.520 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.075119e-03 2.512 0 0
Regulation of TP53 Activity R-HSA-5633007 2.965406e-03 2.528 0 0
Autophagy R-HSA-9612973 3.545204e-03 2.450 0 0
TRP channels R-HSA-3295583 3.938230e-03 2.405 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.847321e-03 2.415 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.847321e-03 2.415 0 0
Mitotic Anaphase R-HSA-68882 3.871641e-03 2.412 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.643034e-03 2.439 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.850783e-03 2.414 0 0
Centrosome maturation R-HSA-380287 3.964770e-03 2.402 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.080372e-03 2.389 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.167821e-03 2.380 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.084056e-03 2.389 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.175038e-03 2.379 0 0
Gap junction trafficking and regulation R-HSA-157858 4.304740e-03 2.366 0 0
Gap junction trafficking R-HSA-190828 4.389304e-03 2.358 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.100500e-03 2.292 0 0
Signaling by NTRKs R-HSA-166520 5.064292e-03 2.295 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.022824e-03 2.299 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.169584e-03 2.287 0 0
Signaling by ALK in cancer R-HSA-9700206 5.169584e-03 2.287 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.490520e-03 2.260 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.483200e-03 2.261 0 0
Cytokine Signaling in Immune system R-HSA-1280215 5.398830e-03 2.268 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 5.508921e-03 2.259 0 0
ALK mutants bind TKIs R-HSA-9700645 5.508921e-03 2.259 0 0
Regulation of IFNG signaling R-HSA-877312 5.740256e-03 2.241 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.110606e-03 2.214 1 1
Signaling downstream of RAS mutants R-HSA-9649948 6.110606e-03 2.214 1 1
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.110606e-03 2.214 1 1
NRAGE signals death through JNK R-HSA-193648 5.655328e-03 2.248 0 0
Signaling by RAS mutants R-HSA-6802949 6.110606e-03 2.214 1 0
Heme signaling R-HSA-9707616 6.195079e-03 2.208 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.655328e-03 2.248 0 0
G2/M Transition R-HSA-69275 6.183975e-03 2.209 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.154871e-03 2.145 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 7.158676e-03 2.145 0 0
Macroautophagy R-HSA-1632852 7.228434e-03 2.141 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 7.471986e-03 2.127 0 0
DNA Double-Strand Break Repair R-HSA-5693532 7.771740e-03 2.109 0 0
Platelet calcium homeostasis R-HSA-418360 7.471986e-03 2.127 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.859319e-03 2.105 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 8.503956e-03 2.070 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 8.503956e-03 2.070 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 8.503956e-03 2.070 0 0
HDMs demethylate histones R-HSA-3214842 8.834946e-03 2.054 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.095630e-03 2.041 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.095630e-03 2.041 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 8.337490e-03 2.079 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.937155e-03 2.049 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.516254e-03 2.070 0 0
Cilium Assembly R-HSA-5617833 8.363400e-03 2.078 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.944264e-03 2.048 0 0
NGF-stimulated transcription R-HSA-9031628 8.337490e-03 2.079 0 0
L1CAM interactions R-HSA-373760 8.640468e-03 2.063 0 0
Interferon Signaling R-HSA-913531 9.121917e-03 2.040 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.659968e-03 2.015 0 0
Post NMDA receptor activation events R-HSA-438064 9.686820e-03 2.014 0 0
Signaling by ERBB2 R-HSA-1227986 9.878366e-03 2.005 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.091198e-02 1.962 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.119237e-02 1.951 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.119237e-02 1.951 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.082227e-02 1.966 0 0
Diseases of programmed cell death R-HSA-9645723 1.079601e-02 1.967 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.091198e-02 1.962 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.090948e-02 1.962 0 0
TNF signaling R-HSA-75893 1.204079e-02 1.919 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.233387e-02 1.909 0 0
FOXO-mediated transcription R-HSA-9614085 1.234242e-02 1.909 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.279142e-02 1.893 0 0
Axon guidance R-HSA-422475 1.287669e-02 1.890 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 1.423640e-02 1.847 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.315342e-02 1.881 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.386193e-02 1.858 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.423640e-02 1.847 0 0
Voltage gated Potassium channels R-HSA-1296072 1.502348e-02 1.823 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.515417e-02 1.819 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.520583e-02 1.818 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.554149e-02 1.809 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.554149e-02 1.809 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.880380e-02 1.726 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.880380e-02 1.726 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.880380e-02 1.726 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.880380e-02 1.726 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.880380e-02 1.726 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.831778e-02 1.737 1 1
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.769828e-02 1.752 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.831940e-02 1.737 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.753888e-02 1.756 0 0
Protein folding R-HSA-391251 1.796312e-02 1.746 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.783036e-02 1.749 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.764631e-02 1.753 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.889034e-02 1.724 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.643531e-02 1.784 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.576171e-02 1.802 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.884759e-02 1.725 0 0
Nervous system development R-HSA-9675108 1.885970e-02 1.724 0 0
Cellular responses to stress R-HSA-2262752 1.646934e-02 1.783 0 0
PI Metabolism R-HSA-1483255 1.643531e-02 1.784 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 1.911846e-02 1.719 0 0
Neurodegenerative Diseases R-HSA-8863678 1.911846e-02 1.719 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.928709e-02 1.715 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.012070e-02 1.696 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.012070e-02 1.696 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.012070e-02 1.696 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.012070e-02 1.696 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.012070e-02 1.696 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.012070e-02 1.696 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.012070e-02 1.696 0 0
Signaling by LTK R-HSA-9842663 2.012070e-02 1.696 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.153589e-02 1.667 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.199548e-02 1.658 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.202517e-02 1.657 0 0
Gap junction degradation R-HSA-190873 2.202517e-02 1.657 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.226576e-02 1.652 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.226576e-02 1.652 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.236397e-02 1.650 0 0
Activation of BH3-only proteins R-HSA-114452 2.236397e-02 1.650 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.296455e-02 1.639 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.296455e-02 1.639 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.304146e-02 1.637 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.335968e-02 1.632 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.378661e-02 1.624 0 0
Cellular responses to stimuli R-HSA-8953897 2.395945e-02 1.621 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.495612e-02 1.603 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.502219e-02 1.602 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.790919e-02 1.554 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.582905e-02 1.588 0 0
Rab regulation of trafficking R-HSA-9007101 2.695932e-02 1.569 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 2.733358e-02 1.563 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.610239e-02 1.583 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.790919e-02 1.554 0 0
Diseases of DNA repair R-HSA-9675135 2.854190e-02 1.545 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.684692e-02 1.571 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.874191e-02 1.541 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 2.961853e-02 1.528 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.961853e-02 1.528 0 0
Neurexins and neuroligins R-HSA-6794361 2.970420e-02 1.527 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.161318e-02 1.500 0 0
Toll-like Receptor Cascades R-HSA-168898 3.191156e-02 1.496 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.295693e-02 1.482 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.318438e-02 1.479 1 1
Chaperone Mediated Autophagy R-HSA-9613829 3.387790e-02 1.470 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.408068e-02 1.467 0 0
Selective autophagy R-HSA-9663891 3.443723e-02 1.463 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.546548e-02 1.450 0 0
Integrin signaling R-HSA-354192 3.553208e-02 1.449 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.553208e-02 1.449 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.553208e-02 1.449 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 3.868225e-02 1.412 0 0
Signaling by APC mutants R-HSA-4839744 3.868225e-02 1.412 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 3.868225e-02 1.412 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 3.868225e-02 1.412 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 3.868225e-02 1.412 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.819440e-02 1.418 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 3.794735e-02 1.421 0 0
Chromatin modifying enzymes R-HSA-3247509 4.084494e-02 1.389 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.825450e-02 1.417 0 0
G alpha (12/13) signalling events R-HSA-416482 3.819440e-02 1.418 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.091817e-02 1.388 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.099849e-02 1.387 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 4.099849e-02 1.387 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.107442e-02 1.386 0 0
MAP kinase activation R-HSA-450294 4.203997e-02 1.376 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.209736e-02 1.376 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 4.217875e-02 1.375 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.526832e-02 1.344 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.526832e-02 1.344 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 4.389053e-02 1.358 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 4.389053e-02 1.358 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 4.389053e-02 1.358 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.926605e-02 1.307 0 0
Activation of RAC1 R-HSA-428540 4.926605e-02 1.307 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.894126e-02 1.310 0 0
Late endosomal microautophagy R-HSA-9615710 4.387607e-02 1.358 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.516244e-02 1.345 0 0
mRNA Splicing R-HSA-72172 4.844251e-02 1.315 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.926605e-02 1.307 0 0
Homology Directed Repair R-HSA-5693538 4.645017e-02 1.333 0 0
Chromatin organization R-HSA-4839726 4.434260e-02 1.353 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.765542e-02 1.322 0 0
Netrin-1 signaling R-HSA-373752 4.471110e-02 1.350 0 0
DNA Repair R-HSA-73894 4.915774e-02 1.308 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.926605e-02 1.307 0 0
Negative regulation of MET activity R-HSA-6807004 4.894126e-02 1.310 0 0
Ion homeostasis R-HSA-5578775 4.626187e-02 1.335 0 0
Sodium/Calcium exchangers R-HSA-425561 4.926605e-02 1.307 0 0
Signaling by AXIN mutants R-HSA-4839735 4.926605e-02 1.307 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.926605e-02 1.307 0 0
Gap junction assembly R-HSA-190861 4.683766e-02 1.329 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.016763e-02 1.300 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.017935e-02 1.299 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.061891e-02 1.296 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.330773e-02 1.273 0 0
Cardiac conduction R-HSA-5576891 5.373650e-02 1.270 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.437458e-02 1.265 0 0
Interleukin-7 signaling R-HSA-1266695 5.437458e-02 1.265 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.487131e-02 1.261 0 0
FLT3 Signaling R-HSA-9607240 5.504316e-02 1.259 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.521186e-02 1.258 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.521186e-02 1.258 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.521186e-02 1.258 0 0
Interleukin-17 signaling R-HSA-448424 5.581660e-02 1.253 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.606093e-02 1.251 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.659022e-02 1.247 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.680995e-02 1.246 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.718888e-02 1.243 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.800876e-02 1.237 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.800876e-02 1.237 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.800876e-02 1.237 0 0
Regulation by c-FLIP R-HSA-3371378 5.819346e-02 1.235 0 0
Dimerization of procaspase-8 R-HSA-69416 5.819346e-02 1.235 0 0
Formation of annular gap junctions R-HSA-196025 5.819346e-02 1.235 0 0
Vesicle-mediated transport R-HSA-5653656 5.938243e-02 1.226 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.947044e-02 1.226 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 5.954678e-02 1.225 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.546354e-02 1.184 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 6.546354e-02 1.184 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.546354e-02 1.184 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.052397e-02 1.218 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.204193e-02 1.142 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.795381e-02 1.168 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.908271e-02 1.161 1 0
Meiosis R-HSA-1500620 6.908271e-02 1.161 0 0
Myogenesis R-HSA-525793 6.286840e-02 1.202 0 0
MAP2K and MAPK activation R-HSA-5674135 6.172479e-02 1.210 1 1
Listeria monocytogenes entry into host cells R-HSA-8876384 6.768479e-02 1.170 0 0
MTOR signalling R-HSA-165159 6.891610e-02 1.162 0 0
Signaling by WNT in cancer R-HSA-4791275 6.605916e-02 1.180 0 0
Signaling by Interleukins R-HSA-449147 6.305895e-02 1.200 0 0
Smooth Muscle Contraction R-HSA-445355 6.255024e-02 1.204 0 0
Interleukin-1 family signaling R-HSA-446652 6.598426e-02 1.181 0 0
MHC class II antigen presentation R-HSA-2132295 6.502249e-02 1.187 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.214472e-02 1.142 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.214472e-02 1.142 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.214472e-02 1.142 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.261622e-02 1.139 0 0
DNA Double Strand Break Response R-HSA-5693606 7.363076e-02 1.133 0 0
Neuronal System R-HSA-112316 7.466587e-02 1.127 0 0
CASP8 activity is inhibited R-HSA-5218900 7.468071e-02 1.127 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.468071e-02 1.127 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.477934e-02 1.126 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 7.477934e-02 1.126 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 7.477934e-02 1.126 0 0
Interleukin-6 signaling R-HSA-1059683 7.505453e-02 1.125 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.505453e-02 1.125 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 8.905506e-02 1.050 0 0
TRAIL signaling R-HSA-75158 8.905506e-02 1.050 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 8.905506e-02 1.050 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 8.905506e-02 1.050 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 9.325865e-02 1.030 0 0
Regulation of the apoptosome activity R-HSA-9627069 9.325865e-02 1.030 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 9.022437e-02 1.045 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 9.022437e-02 1.045 0 0
Notch-HLH transcription pathway R-HSA-350054 7.846912e-02 1.105 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.417414e-02 1.075 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.493341e-02 1.071 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 9.430808e-02 1.025 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.258814e-02 1.083 0 0
Signaling by EGFR R-HSA-177929 8.309309e-02 1.080 0 0
Formation of apoptosome R-HSA-111458 9.325865e-02 1.030 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 9.019425e-02 1.045 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 8.493578e-02 1.071 0 0
Meiotic recombination R-HSA-912446 9.238115e-02 1.034 0 0
Apoptotic factor-mediated response R-HSA-111471 8.472824e-02 1.072 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 9.022437e-02 1.045 0 0
HSF1-dependent transactivation R-HSA-3371571 9.238115e-02 1.034 0 0
Regulated Necrosis R-HSA-5218859 8.009839e-02 1.096 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.624260e-02 1.118 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 8.905506e-02 1.050 0 0
COPI-mediated anterograde transport R-HSA-6807878 7.584232e-02 1.120 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.624260e-02 1.118 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.147263e-02 1.039 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.147263e-02 1.039 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.633013e-02 1.117 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.148064e-02 1.089 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 8.894131e-02 1.051 0 0
Signaling by PTK6 R-HSA-8848021 8.894131e-02 1.051 0 0
Nuclear Envelope Breakdown R-HSA-2980766 9.078775e-02 1.042 0 0
Tandem pore domain potassium channels R-HSA-1296346 9.325865e-02 1.030 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.614913e-02 1.118 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.430808e-02 1.025 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.430808e-02 1.025 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.417414e-02 1.075 0 0
Growth hormone receptor signaling R-HSA-982772 9.019425e-02 1.045 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.493341e-02 1.071 0 0
Signaling by ALK R-HSA-201556 8.493341e-02 1.071 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 9.325865e-02 1.030 0 0
Nuclear import of Rev protein R-HSA-180746 9.424390e-02 1.026 0 0
IRE1alpha activates chaperones R-HSA-381070 7.809297e-02 1.107 0 0
Signaling by Leptin R-HSA-2586552 9.325865e-02 1.030 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.034761e-02 1.095 0 0
IGF1R signaling cascade R-HSA-2428924 9.657104e-02 1.015 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 9.735719e-02 1.012 0 0
Regulation of TP53 Expression R-HSA-6804754 9.735719e-02 1.012 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 9.735719e-02 1.012 0 0
DSCAM interactions R-HSA-376172 9.735719e-02 1.012 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 9.735719e-02 1.012 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 9.735719e-02 1.012 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 9.735719e-02 1.012 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 9.735719e-02 1.012 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 9.735719e-02 1.012 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 9.735719e-02 1.012 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 9.735719e-02 1.012 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 9.735719e-02 1.012 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 9.735719e-02 1.012 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 9.735719e-02 1.012 0 0
Maturation of nucleoprotein R-HSA-9694631 9.856399e-02 1.006 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.867666e-02 1.006 0 0
Glycolysis R-HSA-70171 9.917709e-02 1.004 0 0
mRNA 3'-end processing R-HSA-72187 1.010491e-01 0.995 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.043679e-01 0.981 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.045919e-01 0.981 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.046890e-01 0.980 0 0
PERK regulates gene expression R-HSA-381042 1.049845e-01 0.979 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.050383e-01 0.979 0 0
DCC mediated attractive signaling R-HSA-418885 1.068487e-01 0.971 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.068487e-01 0.971 0 0
Formation of the anterior neural plate R-HSA-9823739 1.068487e-01 0.971 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.085726e-01 0.964 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.226500e-01 0.911 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.226500e-01 0.911 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.226500e-01 0.911 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.400418e-01 0.854 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.400418e-01 0.854 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.447886e-01 0.839 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.447886e-01 0.839 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.361199e-01 0.866 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 1.361199e-01 0.866 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 1.248552e-01 0.904 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.248552e-01 0.904 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.135172e-01 0.945 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.441543e-01 0.841 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.295439e-01 0.888 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.308541e-01 0.883 0 0
EGFR downregulation R-HSA-182971 1.170849e-01 0.931 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.411257e-01 0.850 0 0
Circadian clock R-HSA-9909396 1.226341e-01 0.911 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.356391e-01 0.868 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.440945e-01 0.841 0 0
ERK/MAPK targets R-HSA-198753 1.295439e-01 0.888 0 0
Formation of the posterior neural plate R-HSA-9832991 1.137934e-01 0.944 0 0
RET signaling R-HSA-8853659 1.163876e-01 0.934 0 0
Formation of definitive endoderm R-HSA-9823730 1.135172e-01 0.945 0 0
CREB phosphorylation R-HSA-199920 1.156442e-01 0.937 0 0
Trafficking of AMPA receptors R-HSA-399719 1.170849e-01 0.931 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.123869e-01 0.949 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.164111e-01 0.934 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.266288e-01 0.897 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.095534e-01 0.960 0 0
FasL/ CD95L signaling R-HSA-75157 1.400418e-01 0.854 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.135172e-01 0.945 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.440945e-01 0.841 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.400418e-01 0.854 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 1.447886e-01 0.839 0 0
Co-stimulation by CD28 R-HSA-389356 1.229965e-01 0.910 0 0
Inositol phosphate metabolism R-HSA-1483249 1.438921e-01 0.842 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.309855e-01 0.883 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.170849e-01 0.931 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.440945e-01 0.841 0 0
Potassium Channels R-HSA-1296071 1.166418e-01 0.933 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.440945e-01 0.841 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.137934e-01 0.944 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.441543e-01 0.841 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.458591e-01 0.836 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 1.458591e-01 0.836 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.461418e-01 0.835 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 1.461418e-01 0.835 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.465895e-01 0.834 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.465895e-01 0.834 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.465895e-01 0.834 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.465895e-01 0.834 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.586547e-01 0.800 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.600497e-01 0.796 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 1.600497e-01 0.796 0 0
OAS antiviral response R-HSA-8983711 1.600497e-01 0.796 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.626151e-01 0.789 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 1.645899e-01 0.784 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 1.646427e-01 0.783 0 0
Interleukin-2 family signaling R-HSA-451927 1.683088e-01 0.774 0 0
Mitotic Prophase R-HSA-68875 1.693201e-01 0.771 0 0
MAPK family signaling cascades R-HSA-5683057 1.713116e-01 0.766 1 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.302632e-01 0.638 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.302632e-01 0.638 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.302632e-01 0.638 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.302632e-01 0.638 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.302632e-01 0.638 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.302632e-01 0.638 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.302632e-01 0.638 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.302632e-01 0.638 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.302632e-01 0.638 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.302632e-01 0.638 0 0
Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) R-HSA-5619088 2.302632e-01 0.638 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.302632e-01 0.638 0 0
TWIK-related spinal cord K+ channel (TRESK) R-HSA-1299344 2.302632e-01 0.638 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.858374e-01 0.731 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.858374e-01 0.731 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 1.858374e-01 0.731 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.246824e-01 0.489 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.246824e-01 0.489 0 0
Mitochondrial transcription initiation R-HSA-163282 3.246824e-01 0.489 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 3.246824e-01 0.489 0 0
Intestinal infectious diseases R-HSA-8942233 3.246824e-01 0.489 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.246824e-01 0.489 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.246824e-01 0.489 0 0
TRAF3 deficiency - HSE R-HSA-5602571 3.246824e-01 0.489 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.246824e-01 0.489 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.246824e-01 0.489 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.246824e-01 0.489 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.246824e-01 0.489 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.246824e-01 0.489 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 3.246824e-01 0.489 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.246824e-01 0.489 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.246824e-01 0.489 0 0
XAV939 stabilizes AXIN R-HSA-5545619 3.246824e-01 0.489 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 3.246824e-01 0.489 0 0
IRS activation R-HSA-74713 2.333398e-01 0.632 0 0
G2 Phase R-HSA-68911 2.333398e-01 0.632 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.333398e-01 0.632 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 2.089140e-01 0.680 0 0
ARMS-mediated activation R-HSA-170984 2.089140e-01 0.680 0 0
Interleukin-21 signaling R-HSA-9020958 2.089140e-01 0.680 0 0
WNT mediated activation of DVL R-HSA-201688 2.089140e-01 0.680 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.814418e-01 0.551 0 0
PKB-mediated events R-HSA-109703 2.814418e-01 0.551 0 0
PDE3B signalling R-HSA-165160 2.814418e-01 0.551 0 0
Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 2.814418e-01 0.551 0 0
Essential pentosuria R-HSA-5662853 4.075245e-01 0.390 0 0
Potassium transport channels R-HSA-1296067 4.075245e-01 0.390 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 4.075245e-01 0.390 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.075245e-01 0.390 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.075245e-01 0.390 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.075245e-01 0.390 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.075245e-01 0.390 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.075245e-01 0.390 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.853790e-01 0.732 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.853790e-01 0.732 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.292824e-01 0.482 0 0
Signaling by LTK in cancer R-HSA-9842640 3.292824e-01 0.482 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.862059e-01 0.730 0 0
Ephrin signaling R-HSA-3928664 1.862059e-01 0.730 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 2.778977e-01 0.556 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 2.778977e-01 0.556 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.393832e-01 0.621 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.393832e-01 0.621 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.393832e-01 0.621 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 3.132180e-01 0.504 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.132180e-01 0.504 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 3.762022e-01 0.425 0 0
CHL1 interactions R-HSA-447041 3.762022e-01 0.425 0 0
Netrin mediated repulsion signals R-HSA-418886 3.762022e-01 0.425 0 0
SOS-mediated signalling R-HSA-112412 3.762022e-01 0.425 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 3.762022e-01 0.425 0 0
Recycling of eIF2:GDP R-HSA-72731 3.762022e-01 0.425 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.762022e-01 0.425 0 0
Axonal growth stimulation R-HSA-209563 4.802085e-01 0.319 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.802085e-01 0.319 0 0
MET activates PTPN11 R-HSA-8865999 4.802085e-01 0.319 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.802085e-01 0.319 0 0
Invadopodia formation R-HSA-8941237 4.802085e-01 0.319 0 0
Defective CYP7B1 causes SPG5A and CBAS3 R-HSA-5579013 4.802085e-01 0.319 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 4.802085e-01 0.319 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.966195e-01 0.706 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.966195e-01 0.706 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 2.964247e-01 0.528 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.486320e-01 0.458 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 3.486320e-01 0.458 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.486320e-01 0.458 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.486320e-01 0.458 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 3.486320e-01 0.458 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.335742e-01 0.632 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 3.255722e-01 0.487 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.255722e-01 0.487 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.217076e-01 0.375 0 0
Type I hemidesmosome assembly R-HSA-446107 4.217076e-01 0.375 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.217076e-01 0.375 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.217076e-01 0.375 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.528593e-01 0.597 0 0
Metabolism of non-coding RNA R-HSA-194441 1.745264e-01 0.758 0 0
snRNP Assembly R-HSA-191859 1.745264e-01 0.758 0 0
FGFR2 alternative splicing R-HSA-6803529 3.057200e-01 0.515 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 3.838446e-01 0.416 0 0
Interleukin receptor SHC signaling R-HSA-912526 3.310535e-01 0.480 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 3.106421e-01 0.508 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.106421e-01 0.508 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 2.792992e-01 0.554 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.333181e-01 0.477 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 3.333181e-01 0.477 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 3.565698e-01 0.448 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.565698e-01 0.448 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 3.841875e-01 0.415 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 3.841875e-01 0.415 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 4.185998e-01 0.378 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.654397e-01 0.332 0 0
Lipophagy R-HSA-9613354 4.654397e-01 0.332 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.654397e-01 0.332 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.808503e-01 0.552 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.966778e-01 0.528 0 0
RUNX2 regulates bone development R-HSA-8941326 3.338392e-01 0.476 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.561794e-01 0.448 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 2.816518e-01 0.550 0 0
Translation initiation complex formation R-HSA-72649 2.972008e-01 0.527 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 4.133225e-01 0.384 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.526795e-01 0.344 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 4.526795e-01 0.344 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.305798e-01 0.481 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.071489e-01 0.295 0 0
2-LTR circle formation R-HSA-164843 5.071489e-01 0.295 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.071489e-01 0.295 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.330807e-01 0.363 0 0
Phosphorylation of the APC/C R-HSA-176412 4.859015e-01 0.313 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.537222e-01 0.451 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.799644e-01 0.553 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.110820e-01 0.386 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.400863e-01 0.468 0 0
Telomere Extension By Telomerase R-HSA-171319 4.582297e-01 0.339 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 4.582297e-01 0.339 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.478318e-01 0.349 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.039998e-01 0.394 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.263748e-01 0.370 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 4.704204e-01 0.328 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 4.704204e-01 0.328 0 0
Signaling by Erythropoietin R-HSA-9006335 4.830504e-01 0.316 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 4.830504e-01 0.316 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.983585e-01 0.302 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.983585e-01 0.302 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.181170e-01 0.286 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.181170e-01 0.286 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 4.043300e-01 0.393 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.043300e-01 0.393 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.927451e-01 0.307 0 0
Activation of the pre-replicative complex R-HSA-68962 5.074646e-01 0.295 0 0
Dual incision in TC-NER R-HSA-6782135 4.956634e-01 0.305 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.421456e-01 0.354 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.421456e-01 0.354 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.255722e-01 0.487 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.255722e-01 0.487 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 3.142044e-01 0.503 0 0
Regulation of CDH1 Function R-HSA-9764561 2.368487e-01 0.626 0 0
HATs acetylate histones R-HSA-3214847 3.697765e-01 0.432 0 0
Nucleotide Excision Repair R-HSA-5696398 3.655670e-01 0.437 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.430056e-01 0.614 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.838446e-01 0.416 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.548844e-01 0.450 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 2.971262e-01 0.527 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.087215e-01 0.680 0 0
Prolonged ERK activation events R-HSA-169893 2.676289e-01 0.572 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.945043e-01 0.531 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.945043e-01 0.531 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.573001e-01 0.447 0 0
EPH-Ephrin signaling R-HSA-2682334 2.673100e-01 0.573 0 0
Extension of Telomeres R-HSA-180786 5.134411e-01 0.290 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.128221e-01 0.505 0 0
IRS-mediated signalling R-HSA-112399 3.475372e-01 0.459 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.830504e-01 0.316 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.181170e-01 0.286 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.650801e-01 0.332 0 0
Insulin receptor signalling cascade R-HSA-74751 3.447583e-01 0.462 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.945043e-01 0.531 0 0
Signaling by FGFR2 R-HSA-5654738 3.685290e-01 0.434 0 0
G1/S Transition R-HSA-69206 4.676512e-01 0.330 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.693458e-01 0.329 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.693458e-01 0.329 0 0
Signal attenuation R-HSA-74749 2.430056e-01 0.614 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.048731e-01 0.393 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.591182e-01 0.338 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.307792e-01 0.366 0 0
p75NTR signals via NF-kB R-HSA-193639 2.393832e-01 0.621 0 0
Frs2-mediated activation R-HSA-170968 3.838446e-01 0.416 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.454846e-01 0.610 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 3.547079e-01 0.450 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.661990e-01 0.575 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.959565e-01 0.529 0 0
Josephin domain DUBs R-HSA-5689877 2.430056e-01 0.614 0 0
PI3K Cascade R-HSA-109704 2.335723e-01 0.632 0 0
G2/M Checkpoints R-HSA-69481 1.784677e-01 0.748 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 3.646260e-01 0.438 0 0
Signaling by FGFR4 R-HSA-5654743 3.526276e-01 0.453 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.738748e-01 0.760 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.427677e-01 0.354 0 0
Interleukin-15 signaling R-HSA-8983432 3.486320e-01 0.458 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.802527e-01 0.319 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.132519e-01 0.290 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.858374e-01 0.731 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 2.089140e-01 0.680 0 0
Regulation of CDH11 function R-HSA-9762292 2.430056e-01 0.614 0 0
PI3K/AKT activation R-HSA-198203 2.430056e-01 0.614 0 0
Diseases of mitotic cell cycle R-HSA-9675126 2.335742e-01 0.632 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.255722e-01 0.487 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.725957e-01 0.564 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.716384e-01 0.566 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.134411e-01 0.290 0 0
Signaling by FGFR1 R-HSA-5654736 4.596255e-01 0.338 0 0
Signaling by FGFR3 R-HSA-5654741 3.915552e-01 0.407 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.573001e-01 0.447 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.862059e-01 0.730 0 0
Activation of SMO R-HSA-5635838 4.859015e-01 0.313 0 0
Interleukin-9 signaling R-HSA-8985947 1.760298e-01 0.754 0 0
Interleukin-6 family signaling R-HSA-6783589 2.031610e-01 0.692 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.368487e-01 0.626 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.292824e-01 0.482 0 0
RAF activation R-HSA-5673000 1.738748e-01 0.760 1 1
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.983585e-01 0.302 0 0
Nuclear RNA decay R-HSA-9930044 4.021213e-01 0.396 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.115303e-01 0.506 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.862059e-01 0.730 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.076898e-01 0.390 0 0
Hedgehog 'off' state R-HSA-5610787 2.905148e-01 0.537 0 0
Signalling to ERKs R-HSA-187687 4.704204e-01 0.328 0 0
Long-term potentiation R-HSA-9620244 2.235698e-01 0.651 0 0
Repression of WNT target genes R-HSA-4641265 3.486320e-01 0.458 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.679910e-01 0.572 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.446123e-01 0.612 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.325916e-01 0.633 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.427677e-01 0.354 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.287095e-01 0.483 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.865847e-01 0.413 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.187113e-01 0.497 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.089140e-01 0.680 0 0
Cellular response to mitochondrial stress R-HSA-9840373 2.089140e-01 0.680 0 0
Calcineurin activates NFAT R-HSA-2025928 2.089140e-01 0.680 0 0
Transcription from mitochondrial promoters R-HSA-75944 4.075245e-01 0.390 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.867372e-01 0.729 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.867372e-01 0.729 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.867372e-01 0.729 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.867372e-01 0.729 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.185156e-01 0.661 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.333181e-01 0.477 0 0
Intraflagellar transport R-HSA-5620924 3.143141e-01 0.503 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.326628e-01 0.633 0 0
Cellular Senescence R-HSA-2559583 2.419714e-01 0.616 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.181170e-01 0.286 0 0
Defective pyroptosis R-HSA-9710421 5.007033e-01 0.300 0 0
Signaling by WNT R-HSA-195721 2.187293e-01 0.660 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.595799e-01 0.338 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.966778e-01 0.528 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 4.582297e-01 0.339 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 4.830504e-01 0.316 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.181170e-01 0.286 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 2.446123e-01 0.612 0 0
HIV Life Cycle R-HSA-162587 4.363416e-01 0.360 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.421109e-01 0.466 0 0
RSV-host interactions R-HSA-9833110 3.527808e-01 0.452 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.831214e-01 0.737 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.393832e-01 0.621 0 0
Signaling by Hedgehog R-HSA-5358351 4.659742e-01 0.332 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.966163e-01 0.528 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 1.858374e-01 0.731 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.430056e-01 0.614 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.118953e-01 0.674 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 3.292824e-01 0.482 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.762022e-01 0.425 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.827543e-01 0.738 0 0
Polo-like kinase mediated events R-HSA-156711 3.548844e-01 0.450 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.983585e-01 0.302 0 0
Host Interactions of HIV factors R-HSA-162909 3.537511e-01 0.451 0 0
RMTs methylate histone arginines R-HSA-3214858 2.454846e-01 0.610 0 0
Signaling by NOTCH1 R-HSA-1980143 2.173894e-01 0.663 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.290764e-01 0.483 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.986489e-01 0.525 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.204862e-01 0.657 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 2.333398e-01 0.632 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.760298e-01 0.754 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.953120e-01 0.530 0 0
Rap1 signalling R-HSA-392517 3.841875e-01 0.415 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.131532e-01 0.504 0 0
Deubiquitination R-HSA-5688426 3.895828e-01 0.409 0 0
mRNA Editing R-HSA-75072 4.654397e-01 0.332 0 0
Cardiogenesis R-HSA-9733709 4.021213e-01 0.396 0 0
Interleukin-27 signaling R-HSA-9020956 5.071489e-01 0.295 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.964247e-01 0.528 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.526795e-01 0.344 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.967337e-01 0.402 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 4.859015e-01 0.313 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.048731e-01 0.393 0 0
G-protein beta:gamma signalling R-HSA-397795 4.021213e-01 0.396 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.021213e-01 0.396 0 0
Metabolism of RNA R-HSA-8953854 2.612305e-01 0.583 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.575391e-01 0.447 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.302632e-01 0.638 0 0
Inhibition of PKR R-HSA-169131 2.302632e-01 0.638 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.246824e-01 0.489 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.246824e-01 0.489 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.075245e-01 0.390 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.075245e-01 0.390 0 0
C6 deamination of adenosine R-HSA-75102 4.075245e-01 0.390 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 4.075245e-01 0.390 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.075245e-01 0.390 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.853790e-01 0.732 0 0
Physiological factors R-HSA-5578768 2.118953e-01 0.674 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.676289e-01 0.572 0 0
Phase 4 - resting membrane potential R-HSA-5576886 2.676289e-01 0.572 0 0
Activation of BMF and translocation to mitochondria R-HSA-139910 4.802085e-01 0.319 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.802085e-01 0.319 0 0
MET interacts with TNS proteins R-HSA-8875513 4.802085e-01 0.319 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.230975e-01 0.652 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.217076e-01 0.375 0 0
Co-stimulation by ICOS R-HSA-9927354 4.217076e-01 0.375 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.882391e-01 0.540 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.838446e-01 0.416 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.993339e-01 0.700 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.927162e-01 0.534 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.622209e-01 0.581 0 0
Prolactin receptor signaling R-HSA-1170546 4.185998e-01 0.378 0 0
Metalloprotease DUBs R-HSA-5689901 4.076898e-01 0.390 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 5.071489e-01 0.295 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 4.859015e-01 0.313 0 0
Viral Messenger RNA Synthesis R-HSA-168325 4.163305e-01 0.381 0 0
Signaling by ROBO receptors R-HSA-376176 3.823506e-01 0.418 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.542996e-01 0.595 1 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.867372e-01 0.729 0 0
ESR-mediated signaling R-HSA-8939211 4.289268e-01 0.368 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.524495e-01 0.598 1 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.981083e-01 0.400 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.867372e-01 0.729 0 0
FLT3 signaling in disease R-HSA-9682385 3.338392e-01 0.476 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 3.821519e-01 0.418 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.532215e-01 0.596 0 0
Protein methylation R-HSA-8876725 4.526795e-01 0.344 0 0
Effects of PIP2 hydrolysis R-HSA-114508 4.250427e-01 0.372 0 0
Downstream signal transduction R-HSA-186763 2.148062e-01 0.668 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.233964e-01 0.373 0 0
PECAM1 interactions R-HSA-210990 2.778977e-01 0.556 0 0
TBC/RABGAPs R-HSA-8854214 2.291312e-01 0.640 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.966163e-01 0.528 0 0
HSF1 activation R-HSA-3371511 4.927451e-01 0.307 0 0
Signaling by VEGF R-HSA-194138 3.772642e-01 0.423 0 0
Pyroptosis R-HSA-5620971 2.882391e-01 0.540 0 0
Negative regulation of FLT3 R-HSA-9706369 4.859015e-01 0.313 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.129519e-01 0.384 0 0
Signaling by SCF-KIT R-HSA-1433557 3.526276e-01 0.453 0 0
Reproduction R-HSA-1474165 2.819592e-01 0.550 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.074646e-01 0.295 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.122981e-01 0.673 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.237123e-01 0.650 0 0
Muscarinic acetylcholine receptors R-HSA-390648 2.333398e-01 0.632 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 2.089140e-01 0.680 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.543077e-01 0.595 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.427677e-01 0.354 0 0
Cell-Cell communication R-HSA-1500931 3.985666e-01 0.399 0 0
Signaling by MET R-HSA-6806834 1.853616e-01 0.732 0 0
Signaling by TGFBR3 R-HSA-9839373 2.792992e-01 0.554 0 0
Platelet homeostasis R-HSA-418346 3.784304e-01 0.422 0 0
Signaling by ERBB4 R-HSA-1236394 3.883719e-01 0.411 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 4.591182e-01 0.338 1 1
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.762022e-01 0.425 0 0
mTORC1-mediated signalling R-HSA-166208 3.057200e-01 0.515 0 0
Regulation of KIT signaling R-HSA-1433559 4.185998e-01 0.378 0 0
TGFBR3 expression R-HSA-9839394 3.821519e-01 0.418 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.664877e-01 0.331 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 4.705285e-01 0.327 0 0
Semaphorin interactions R-HSA-373755 4.508274e-01 0.346 0 0
Platelet degranulation R-HSA-114608 4.921152e-01 0.308 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 2.560955e-01 0.592 0 0
Calmodulin induced events R-HSA-111933 3.338392e-01 0.476 0 0
Interleukin-12 family signaling R-HSA-447115 3.786842e-01 0.422 0 0
Inhibition of membrane repair R-HSA-9635644 3.246824e-01 0.489 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 2.333398e-01 0.632 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.814418e-01 0.551 0 0
Maturation of nucleoprotein R-HSA-9683610 1.853790e-01 0.732 0 0
Platelet sensitization by LDL R-HSA-432142 1.862059e-01 0.730 0 0
Synthesis of PI R-HSA-1483226 2.778977e-01 0.556 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.802085e-01 0.319 0 0
Syndecan interactions R-HSA-3000170 3.310535e-01 0.480 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.927162e-01 0.534 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.054280e-01 0.687 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.185998e-01 0.378 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.654397e-01 0.332 0 0
CaM pathway R-HSA-111997 3.338392e-01 0.476 0 0
G0 and Early G1 R-HSA-1538133 3.791411e-01 0.421 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.021213e-01 0.396 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.071489e-01 0.295 0 0
Glucose metabolism R-HSA-70326 2.745911e-01 0.561 0 0
DAG and IP3 signaling R-HSA-1489509 3.915552e-01 0.407 0 0
GPVI-mediated activation cascade R-HSA-114604 4.927451e-01 0.307 0 0
Stimuli-sensing channels R-HSA-2672351 3.126157e-01 0.505 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.974986e-01 0.303 0 0
Sensory processing of sound R-HSA-9659379 4.665414e-01 0.331 0 0
Ca-dependent events R-HSA-111996 4.802527e-01 0.319 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.292824e-01 0.482 0 0
Histamine receptors R-HSA-390650 4.802085e-01 0.319 0 0
Tie2 Signaling R-HSA-210993 3.548844e-01 0.450 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.756938e-01 0.425 0 0
PTEN Regulation R-HSA-6807070 4.776201e-01 0.321 0 0
Co-inhibition by BTLA R-HSA-9927353 2.333398e-01 0.632 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.075245e-01 0.390 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.762022e-01 0.425 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.762022e-01 0.425 0 0
Regulation of PTEN localization R-HSA-8948747 3.762022e-01 0.425 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.827543e-01 0.738 0 0
Sodium/Proton exchangers R-HSA-425986 4.217076e-01 0.375 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.225480e-01 0.653 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.654397e-01 0.332 0 0
MAPK3 (ERK1) activation R-HSA-110056 5.071489e-01 0.295 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.872265e-01 0.312 1 0
P2Y receptors R-HSA-417957 4.185998e-01 0.378 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.071489e-01 0.295 0 0
Specification of primordial germ cells R-HSA-9827857 3.255722e-01 0.487 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.420900e-01 0.354 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.814418e-01 0.551 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.778977e-01 0.556 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 4.217076e-01 0.375 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.792992e-01 0.554 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 4.133225e-01 0.384 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 4.526795e-01 0.344 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 4.705285e-01 0.327 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.207334e-01 0.656 0 0
Metal ion SLC transporters R-HSA-425410 2.038631e-01 0.691 0 0
Interleukin-12 signaling R-HSA-9020591 3.100293e-01 0.509 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.654397e-01 0.332 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.531926e-01 0.597 0 0
Zinc transporters R-HSA-435354 4.185998e-01 0.378 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.421456e-01 0.354 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 3.057200e-01 0.515 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 3.548844e-01 0.450 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.238072e-01 0.281 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.255381e-01 0.279 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 5.255381e-01 0.279 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.263909e-01 0.279 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.310169e-01 0.275 0 0
Budding and maturation of HIV virion R-HSA-162588 5.314027e-01 0.275 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.336062e-01 0.273 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.336062e-01 0.273 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.359521e-01 0.271 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.368336e-01 0.270 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.368336e-01 0.270 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.407604e-01 0.267 0 0
Interferon gamma signaling R-HSA-877300 5.414422e-01 0.266 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 5.430531e-01 0.265 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.435172e-01 0.265 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.439794e-01 0.264 0 0
NADE modulates death signalling R-HSA-205025 5.439794e-01 0.264 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.439794e-01 0.264 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.439794e-01 0.264 0 0
Regulation of gap junction activity R-HSA-191650 5.439794e-01 0.264 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.439794e-01 0.264 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.439794e-01 0.264 0 0
Alanine metabolism R-HSA-8964540 5.439794e-01 0.264 0 0
Transmission across Electrical Synapses R-HSA-112307 5.439794e-01 0.264 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.439794e-01 0.264 0 0
Dopamine receptors R-HSA-390651 5.439794e-01 0.264 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.439794e-01 0.264 0 0
Interleukin-38 signaling R-HSA-9007892 5.439794e-01 0.264 0 0
Meiotic synapsis R-HSA-1221632 5.447224e-01 0.264 0 0
HIV Infection R-HSA-162906 5.465207e-01 0.262 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 5.466735e-01 0.262 0 0
Interleukin-2 signaling R-HSA-9020558 5.466735e-01 0.262 0 0
Bicarbonate transporters R-HSA-425381 5.466735e-01 0.262 0 0
Suppression of apoptosis R-HSA-9635465 5.466735e-01 0.262 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.492075e-01 0.260 0 0
Deadenylation of mRNA R-HSA-429947 5.519842e-01 0.258 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 5.519842e-01 0.258 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 5.519842e-01 0.258 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 5.548032e-01 0.256 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.558555e-01 0.255 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.558555e-01 0.255 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.602871e-01 0.252 0 0
Signaling by FGFR R-HSA-190236 5.635009e-01 0.249 0 0
tRNA processing in the nucleus R-HSA-6784531 5.654517e-01 0.248 0 0
Hemostasis R-HSA-109582 5.668742e-01 0.247 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 5.679124e-01 0.246 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.710414e-01 0.243 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.756469e-01 0.240 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 5.776132e-01 0.238 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.776132e-01 0.238 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.776132e-01 0.238 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 5.776278e-01 0.238 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.783227e-01 0.238 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.783227e-01 0.238 0 0
PKA activation R-HSA-163615 5.790825e-01 0.237 0 0
PKA activation in glucagon signalling R-HSA-164378 5.790825e-01 0.237 0 0
Synaptic adhesion-like molecules R-HSA-8849932 5.790825e-01 0.237 0 0
GAB1 signalosome R-HSA-180292 5.790825e-01 0.237 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 5.790825e-01 0.237 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.794324e-01 0.237 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.794324e-01 0.237 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 5.839216e-01 0.234 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.839216e-01 0.234 0 0
Integration of provirus R-HSA-162592 5.839216e-01 0.234 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.839216e-01 0.234 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 5.839216e-01 0.234 0 0
NF-kB is activated and signals survival R-HSA-209560 5.839216e-01 0.234 0 0
S Phase R-HSA-69242 5.909303e-01 0.228 0 0
Gene Silencing by RNA R-HSA-211000 5.920777e-01 0.228 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.953660e-01 0.225 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.982917e-01 0.223 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.982917e-01 0.223 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.985629e-01 0.223 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.985629e-01 0.223 0 0
Ion transport by P-type ATPases R-HSA-936837 5.987656e-01 0.223 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 5.987656e-01 0.223 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.999299e-01 0.222 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.999299e-01 0.222 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 5.999299e-01 0.222 0 0
Defective F9 activation R-HSA-9673221 5.999299e-01 0.222 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.999299e-01 0.222 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.999299e-01 0.222 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.999299e-01 0.222 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.999299e-01 0.222 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.999299e-01 0.222 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.999299e-01 0.222 0 0
Activation of AKT2 R-HSA-165158 5.999299e-01 0.222 0 0
PTK6 Down-Regulation R-HSA-8849472 5.999299e-01 0.222 0 0
Activation of C3 and C5 R-HSA-174577 5.999299e-01 0.222 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 5.999299e-01 0.222 0 0
Inositol transporters R-HSA-429593 5.999299e-01 0.222 0 0
NrCAM interactions R-HSA-447038 5.999299e-01 0.222 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.999299e-01 0.222 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.999299e-01 0.222 0 0
Signaling by EGFR in Cancer R-HSA-1643713 6.024130e-01 0.220 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.024130e-01 0.220 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.024130e-01 0.220 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.036096e-01 0.219 0 0
Translesion Synthesis by POLH R-HSA-110320 6.076758e-01 0.216 0 0
Specification of the neural plate border R-HSA-9834899 6.076758e-01 0.216 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 6.076758e-01 0.216 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.076758e-01 0.216 0 0
HCMV Early Events R-HSA-9609690 6.108364e-01 0.214 0 0
Cellular response to starvation R-HSA-9711097 6.137783e-01 0.212 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.159421e-01 0.210 0 0
DNA Damage Bypass R-HSA-73893 6.164598e-01 0.210 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.180318e-01 0.209 0 0
Interferon alpha/beta signaling R-HSA-909733 6.182018e-01 0.209 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.182702e-01 0.209 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.182702e-01 0.209 1 1
RUNX3 regulates p14-ARF R-HSA-8951936 6.188569e-01 0.208 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.188569e-01 0.208 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.188569e-01 0.208 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 6.188569e-01 0.208 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 6.188569e-01 0.208 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.188569e-01 0.208 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.188569e-01 0.208 0 0
Interleukin-35 Signalling R-HSA-8984722 6.188569e-01 0.208 0 0
MET activates RAS signaling R-HSA-8851805 6.188569e-01 0.208 0 0
VLDLR internalisation and degradation R-HSA-8866427 6.188569e-01 0.208 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.188569e-01 0.208 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 6.188569e-01 0.208 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.188569e-01 0.208 0 0
Ion channel transport R-HSA-983712 6.189574e-01 0.208 0 0
Dual Incision in GG-NER R-HSA-5696400 6.212880e-01 0.207 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.212880e-01 0.207 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.212880e-01 0.207 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.212880e-01 0.207 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 6.262959e-01 0.203 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.262959e-01 0.203 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.262959e-01 0.203 0 0
Packaging Of Telomere Ends R-HSA-171306 6.262959e-01 0.203 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.262959e-01 0.203 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 6.262959e-01 0.203 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.262959e-01 0.203 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 6.294055e-01 0.201 0 0
Cellular response to chemical stress R-HSA-9711123 6.314193e-01 0.200 0 0
Transmission across Chemical Synapses R-HSA-112315 6.322793e-01 0.199 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.349432e-01 0.197 0 0
Pregnenolone biosynthesis R-HSA-196108 6.349432e-01 0.197 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.374177e-01 0.196 0 0
Mitochondrial biogenesis R-HSA-1592230 6.419709e-01 0.192 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.422410e-01 0.192 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.446561e-01 0.191 0 0
Neutrophil degranulation R-HSA-6798695 6.456268e-01 0.190 0 0
Co-inhibition by PD-1 R-HSA-389948 6.478384e-01 0.189 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.490184e-01 0.188 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.490184e-01 0.188 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.490184e-01 0.188 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.490184e-01 0.188 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.490184e-01 0.188 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.490184e-01 0.188 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.490184e-01 0.188 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.490184e-01 0.188 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.490184e-01 0.188 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.490184e-01 0.188 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.490184e-01 0.188 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.490184e-01 0.188 0 0
Ceramide signalling R-HSA-193681 6.490184e-01 0.188 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 6.490184e-01 0.188 0 0
Formation of the Editosome R-HSA-75094 6.490184e-01 0.188 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.490184e-01 0.188 0 0
Phosphorylation of Emi1 R-HSA-176417 6.490184e-01 0.188 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.490184e-01 0.188 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.490184e-01 0.188 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.490184e-01 0.188 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.490184e-01 0.188 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.490184e-01 0.188 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.490184e-01 0.188 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 6.490184e-01 0.188 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.490184e-01 0.188 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.490184e-01 0.188 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.492439e-01 0.188 0 0
HIV elongation arrest and recovery R-HSA-167287 6.492439e-01 0.188 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.492439e-01 0.188 0 0
Formation of axial mesoderm R-HSA-9796292 6.514861e-01 0.186 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 6.514861e-01 0.186 0 0
FGFR1c ligand binding and activation R-HSA-190373 6.514861e-01 0.186 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 6.514861e-01 0.186 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.514861e-01 0.186 0 0
Processing of SMDT1 R-HSA-8949664 6.514861e-01 0.186 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.514861e-01 0.186 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 6.514861e-01 0.186 0 0
Telomere Maintenance R-HSA-157579 6.550320e-01 0.184 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.550320e-01 0.184 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.550320e-01 0.184 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 6.608592e-01 0.180 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.608592e-01 0.180 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.608592e-01 0.180 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.608592e-01 0.180 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.608592e-01 0.180 0 0
Early Phase of HIV Life Cycle R-HSA-162594 6.608592e-01 0.180 0 0
G1/S-Specific Transcription R-HSA-69205 6.621536e-01 0.179 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.621536e-01 0.179 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.640339e-01 0.178 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.684915e-01 0.175 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 6.690056e-01 0.175 0 0
DNA methylation R-HSA-5334118 6.712345e-01 0.173 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.712345e-01 0.173 0 0
DARPP-32 events R-HSA-180024 6.712345e-01 0.173 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.712345e-01 0.173 0 0
Regulation of gene expression in beta cells R-HSA-210745 6.712345e-01 0.173 0 0
Translation of Structural Proteins R-HSA-9694635 6.731603e-01 0.172 0 0
G1 Phase R-HSA-69236 6.739489e-01 0.171 0 0
Cyclin D associated events in G1 R-HSA-69231 6.739489e-01 0.171 0 0
PLC beta mediated events R-HSA-112043 6.799160e-01 0.168 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 6.814772e-01 0.167 0 0
Cleavage of the damaged purine R-HSA-110331 6.814772e-01 0.167 0 0
Signaling by Insulin receptor R-HSA-74752 6.817216e-01 0.166 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.818493e-01 0.166 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 6.818493e-01 0.166 0 0
NRIF signals cell death from the nucleus R-HSA-205043 6.818493e-01 0.166 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.818493e-01 0.166 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.818493e-01 0.166 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 6.818493e-01 0.166 0 0
Malate-aspartate shuttle R-HSA-9856872 6.818493e-01 0.166 0 0
Signal regulatory protein family interactions R-HSA-391160 6.818493e-01 0.166 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.829895e-01 0.166 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 6.854150e-01 0.164 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.854150e-01 0.164 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.854150e-01 0.164 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 6.854150e-01 0.164 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.854150e-01 0.164 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.854150e-01 0.164 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.920863e-01 0.160 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.920863e-01 0.160 0 0
STAT5 Activation R-HSA-9645135 6.920863e-01 0.160 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.920863e-01 0.160 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.920863e-01 0.160 0 0
Defective CYP11A1 causes AICSR R-HSA-5579026 6.920863e-01 0.160 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.920863e-01 0.160 0 0
Hydrolysis of LPE R-HSA-1483152 6.920863e-01 0.160 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.920863e-01 0.160 0 0
Neurofascin interactions R-HSA-447043 6.920863e-01 0.160 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.920863e-01 0.160 0 0
HDL clearance R-HSA-8964011 6.920863e-01 0.160 0 0
Nef and signal transduction R-HSA-164944 6.920863e-01 0.160 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.922544e-01 0.160 0 0
DAP12 signaling R-HSA-2424491 6.922544e-01 0.160 0 0
Ub-specific processing proteases R-HSA-5689880 6.922882e-01 0.160 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.995045e-01 0.155 0 0
Depurination R-HSA-73927 7.000437e-01 0.155 0 0
Interleukin-1 signaling R-HSA-9020702 7.036156e-01 0.153 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 7.080311e-01 0.150 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.086155e-01 0.150 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.086155e-01 0.150 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.086155e-01 0.150 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 7.086155e-01 0.150 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.086155e-01 0.150 0 0
Signaling by KIT in disease R-HSA-9669938 7.086155e-01 0.150 0 0
LDL clearance R-HSA-8964038 7.086155e-01 0.150 0 0
Erythropoietin activates RAS R-HSA-9027284 7.100111e-01 0.149 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.100111e-01 0.149 0 0
SHC1 events in EGFR signaling R-HSA-180336 7.100111e-01 0.149 0 0
Translesion synthesis by REV1 R-HSA-110312 7.100111e-01 0.149 0 0
Telomere C-strand synthesis initiation R-HSA-174430 7.100111e-01 0.149 0 0
Biotin transport and metabolism R-HSA-196780 7.100111e-01 0.149 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 7.100111e-01 0.149 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 7.100111e-01 0.149 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 7.100111e-01 0.149 0 0
SARS-CoV-1 Infection R-HSA-9678108 7.101734e-01 0.149 0 0
SARS-CoV Infections R-HSA-9679506 7.117789e-01 0.148 0 0
Signaling by TGFB family members R-HSA-9006936 7.117933e-01 0.148 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.122985e-01 0.147 0 0
Developmental Cell Lineages R-HSA-9734767 7.147874e-01 0.146 0 0
Regulation of endogenous retroelements R-HSA-9842860 7.150845e-01 0.146 0 0
HDACs deacetylate histones R-HSA-3214815 7.159283e-01 0.145 0 0
Signaling by NOTCH3 R-HSA-9012852 7.159283e-01 0.145 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 7.178466e-01 0.144 0 0
Peptide chain elongation R-HSA-156902 7.216800e-01 0.142 0 0
Signaling by NOTCH R-HSA-157118 7.226290e-01 0.141 0 0
rRNA processing R-HSA-72312 7.229521e-01 0.141 0 0
Formation of a pool of free 40S subunits R-HSA-72689 7.296273e-01 0.137 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.298717e-01 0.137 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 7.298717e-01 0.137 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.298717e-01 0.137 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 7.298717e-01 0.137 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.298717e-01 0.137 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.298717e-01 0.137 0 0
PTK6 Expression R-HSA-8849473 7.298717e-01 0.137 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.298717e-01 0.137 0 0
Electron transport from NADPH to Ferredoxin R-HSA-2395516 7.298717e-01 0.137 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.298717e-01 0.137 0 0
VLDL clearance R-HSA-8964046 7.298717e-01 0.137 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.298717e-01 0.137 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.298717e-01 0.137 0 0
Maturation of replicase proteins R-HSA-9694301 7.298717e-01 0.137 0 0
Interleukin-20 family signaling R-HSA-8854691 7.304774e-01 0.136 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.304774e-01 0.136 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.306768e-01 0.136 0 0
Ca2+ pathway R-HSA-4086398 7.310507e-01 0.136 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 7.313688e-01 0.136 0 0
HIV Transcription Elongation R-HSA-167169 7.348842e-01 0.134 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 7.348842e-01 0.134 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 7.348842e-01 0.134 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.348842e-01 0.134 0 0
Attenuation phase R-HSA-3371568 7.348842e-01 0.134 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.348842e-01 0.134 0 0
Diseases of Immune System R-HSA-5260271 7.348842e-01 0.134 0 0
Translesion synthesis by POLI R-HSA-5656121 7.360545e-01 0.133 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 7.360545e-01 0.133 0 0
Killing mechanisms R-HSA-9664420 7.360545e-01 0.133 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.360545e-01 0.133 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.360545e-01 0.133 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 7.360545e-01 0.133 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.360545e-01 0.133 0 0
Differentiation of T cells R-HSA-9945266 7.360545e-01 0.133 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 7.360545e-01 0.133 0 0
HCMV Infection R-HSA-9609646 7.368462e-01 0.133 0 0
GPER1 signaling R-HSA-9634597 7.396016e-01 0.131 0 0
Gluconeogenesis R-HSA-70263 7.396016e-01 0.131 0 0
Influenza Infection R-HSA-168255 7.440715e-01 0.128 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.477957e-01 0.126 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.477957e-01 0.126 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.494740e-01 0.125 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.510270e-01 0.124 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.510270e-01 0.124 0 0
Complex III assembly R-HSA-9865881 7.510270e-01 0.124 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 7.510270e-01 0.124 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.510270e-01 0.124 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 7.511591e-01 0.124 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 7.511591e-01 0.124 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.563137e-01 0.121 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 7.585590e-01 0.120 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 7.600752e-01 0.119 0 0
Translesion synthesis by POLK R-HSA-5655862 7.600752e-01 0.119 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.600752e-01 0.119 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.600752e-01 0.119 0 0
Formation of xylulose-5-phosphate R-HSA-5661270 7.600752e-01 0.119 0 0
Disorders of Developmental Biology R-HSA-9675151 7.600752e-01 0.119 0 0
Galactose catabolism R-HSA-70370 7.600752e-01 0.119 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.616440e-01 0.118 0 0
Cell junction organization R-HSA-446728 7.623554e-01 0.118 0 0
RSK activation R-HSA-444257 7.630222e-01 0.117 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.630222e-01 0.117 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 7.630222e-01 0.117 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.630222e-01 0.117 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.630222e-01 0.117 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 7.630222e-01 0.117 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 7.630222e-01 0.117 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.630222e-01 0.117 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.630222e-01 0.117 0 0
Adrenoceptors R-HSA-390696 7.630222e-01 0.117 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.630222e-01 0.117 0 0
Fructose biosynthesis R-HSA-5652227 7.630222e-01 0.117 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.630222e-01 0.117 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.630222e-01 0.117 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.630222e-01 0.117 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.630222e-01 0.117 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.630222e-01 0.117 0 0
Alpha-defensins R-HSA-1462054 7.630222e-01 0.117 0 0
G-protein mediated events R-HSA-112040 7.631221e-01 0.117 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.666278e-01 0.115 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.666278e-01 0.115 0 0
Intra-Golgi traffic R-HSA-6811438 7.666778e-01 0.115 0 0
Translation of Structural Proteins R-HSA-9683701 7.666778e-01 0.115 0 0
Phospholipid metabolism R-HSA-1483257 7.675129e-01 0.115 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.681659e-01 0.115 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.702985e-01 0.113 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.702985e-01 0.113 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.727952e-01 0.112 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.776976e-01 0.109 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.814502e-01 0.107 0 0
Depyrimidination R-HSA-73928 7.814502e-01 0.107 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 7.821775e-01 0.107 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.821775e-01 0.107 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.821775e-01 0.107 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 7.821775e-01 0.107 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.828490e-01 0.106 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 7.828490e-01 0.106 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.842972e-01 0.106 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.883325e-01 0.103 0 0
RNA Polymerase I Transcription R-HSA-73864 7.904014e-01 0.102 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.921061e-01 0.101 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.921061e-01 0.101 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.921061e-01 0.101 0 0
Unwinding of DNA R-HSA-176974 7.921061e-01 0.101 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.921061e-01 0.101 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.921061e-01 0.101 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.921061e-01 0.101 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.921061e-01 0.101 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.921061e-01 0.101 0 0
Interleukin-1 processing R-HSA-448706 7.921061e-01 0.101 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.939746e-01 0.100 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.952175e-01 0.100 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.952175e-01 0.100 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.954890e-01 0.099 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.954890e-01 0.099 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.977182e-01 0.098 0 0
Oncogene Induced Senescence R-HSA-2559585 7.981600e-01 0.098 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.984168e-01 0.098 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.024702e-01 0.096 0 0
FGFR1 ligand binding and activation R-HSA-190242 8.024702e-01 0.096 0 0
Mismatch Repair R-HSA-5358508 8.024702e-01 0.096 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.024702e-01 0.096 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.024702e-01 0.096 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 8.024702e-01 0.096 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 8.051742e-01 0.094 0 0
Cristae formation R-HSA-8949613 8.051742e-01 0.094 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 8.051742e-01 0.094 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.051742e-01 0.094 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 8.075903e-01 0.093 0 0
Signaling by PDGF R-HSA-186797 8.079288e-01 0.093 0 0
Amine ligand-binding receptors R-HSA-375280 8.088098e-01 0.092 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 8.092619e-01 0.092 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 8.112488e-01 0.091 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.125867e-01 0.090 0 0
Triglyceride catabolism R-HSA-163560 8.125867e-01 0.090 0 0
RNA Polymerase III Transcription R-HSA-74158 8.125867e-01 0.090 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.125867e-01 0.090 0 0
Pexophagy R-HSA-9664873 8.176221e-01 0.087 0 0
Binding and entry of HIV virion R-HSA-173107 8.176221e-01 0.087 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.176221e-01 0.087 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 8.176221e-01 0.087 0 0
Metabolism of serotonin R-HSA-380612 8.176221e-01 0.087 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.176221e-01 0.087 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.176221e-01 0.087 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.176221e-01 0.087 0 0
Arachidonate production from DAG R-HSA-426048 8.176221e-01 0.087 0 0
Receptor Mediated Mitophagy R-HSA-8934903 8.176221e-01 0.087 0 0
Maturation of spike protein R-HSA-9683686 8.176221e-01 0.087 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.176221e-01 0.087 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.193714e-01 0.087 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.193714e-01 0.087 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.208726e-01 0.086 0 0
Regulation of signaling by CBL R-HSA-912631 8.210647e-01 0.086 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.210647e-01 0.086 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.210647e-01 0.086 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.210647e-01 0.086 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.210647e-01 0.086 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.210647e-01 0.086 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.210647e-01 0.086 0 0
Other interleukin signaling R-HSA-449836 8.210647e-01 0.086 0 0
The NLRP3 inflammasome R-HSA-844456 8.210647e-01 0.086 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.214300e-01 0.085 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.214300e-01 0.085 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 8.261574e-01 0.083 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.380719e-01 0.077 0 0
Glycogen synthesis R-HSA-3322077 8.380719e-01 0.077 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.380719e-01 0.077 0 0
Signal transduction by L1 R-HSA-445144 8.380719e-01 0.077 0 0
MET promotes cell motility R-HSA-8875878 8.389026e-01 0.076 0 0
Signaling by FGFR in disease R-HSA-1226099 8.391283e-01 0.076 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.400077e-01 0.076 0 0
LGI-ADAM interactions R-HSA-5682910 8.400077e-01 0.076 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.400077e-01 0.076 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.400077e-01 0.076 0 0
vRNA Synthesis R-HSA-192814 8.400077e-01 0.076 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.400077e-01 0.076 0 0
Cholesterol biosynthesis via desmosterol R-HSA-6807047 8.400077e-01 0.076 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.400077e-01 0.076 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.400077e-01 0.076 0 0
Transport of RCbl within the body R-HSA-9758890 8.400077e-01 0.076 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.400077e-01 0.076 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.405166e-01 0.075 0 0
Chromosome Maintenance R-HSA-73886 8.405800e-01 0.075 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 8.453480e-01 0.073 0 0
Adherens junctions interactions R-HSA-418990 8.463596e-01 0.072 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.478867e-01 0.072 0 0
Neurotransmitter clearance R-HSA-112311 8.490466e-01 0.071 0 0
Stabilization of p53 R-HSA-69541 8.508543e-01 0.070 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.508543e-01 0.070 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.508543e-01 0.070 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.512023e-01 0.070 0 0
Lagging Strand Synthesis R-HSA-69186 8.536013e-01 0.069 0 0
Signalling to RAS R-HSA-167044 8.536013e-01 0.069 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 8.536013e-01 0.069 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.569016e-01 0.067 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.596467e-01 0.066 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.596467e-01 0.066 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.596467e-01 0.066 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.596467e-01 0.066 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.596467e-01 0.066 0 0
ERKs are inactivated R-HSA-202670 8.596467e-01 0.066 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.596467e-01 0.066 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.596467e-01 0.066 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.596467e-01 0.066 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.608660e-01 0.065 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.620455e-01 0.064 0 0
Adipogenesis R-HSA-9843745 8.630676e-01 0.064 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.642535e-01 0.063 0 0
Degradation of CDH1 R-HSA-9766229 8.653141e-01 0.063 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.654189e-01 0.063 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.677594e-01 0.062 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 8.677594e-01 0.062 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 8.677594e-01 0.062 0 0
Assembly Of The HIV Virion R-HSA-175474 8.677594e-01 0.062 0 0
Regulation of beta-cell development R-HSA-186712 8.699127e-01 0.061 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.725101e-01 0.059 0 0
Maturation of spike protein R-HSA-9694548 8.725101e-01 0.059 0 0
DNA strand elongation R-HSA-69190 8.732803e-01 0.059 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.732803e-01 0.059 0 0
HCMV Late Events R-HSA-9610379 8.743631e-01 0.058 0 0
Adaptive Immune System R-HSA-1280218 8.755196e-01 0.058 0 0
Polymerase switching R-HSA-69091 8.768760e-01 0.057 0 0
Leading Strand Synthesis R-HSA-69109 8.768760e-01 0.057 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.768760e-01 0.057 0 0
Proline catabolism R-HSA-70688 8.768760e-01 0.057 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.768760e-01 0.057 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.768760e-01 0.057 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.768760e-01 0.057 0 0
Pervasive developmental disorders R-HSA-9005895 8.768760e-01 0.057 0 0
Disorders of Nervous System Development R-HSA-9697154 8.768760e-01 0.057 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.768760e-01 0.057 0 0
Estrogen biosynthesis R-HSA-193144 8.768760e-01 0.057 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.768760e-01 0.057 0 0
Gastrulation R-HSA-9758941 8.781342e-01 0.056 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.784465e-01 0.056 0 0
GABA receptor activation R-HSA-977443 8.784634e-01 0.056 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.806488e-01 0.055 0 0
Fructose metabolism R-HSA-5652084 8.806488e-01 0.055 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 8.806488e-01 0.055 0 0
Ethanol oxidation R-HSA-71384 8.806488e-01 0.055 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.806488e-01 0.055 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 8.806488e-01 0.055 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.822821e-01 0.054 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.836146e-01 0.054 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.850773e-01 0.053 0 0
Eukaryotic Translation Termination R-HSA-72764 8.850773e-01 0.053 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.865364e-01 0.052 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.902892e-01 0.050 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.902892e-01 0.050 0 0
Hedgehog 'on' state R-HSA-5632684 8.902892e-01 0.050 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 8.913956e-01 0.050 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.913956e-01 0.050 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.919913e-01 0.050 0 0
FGFR2c ligand binding and activation R-HSA-190375 8.919913e-01 0.050 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.919913e-01 0.050 0 0
FGFR4 ligand binding and activation R-HSA-190322 8.919913e-01 0.050 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 8.919913e-01 0.050 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.919913e-01 0.050 0 0
FGFR3 mutant receptor activation R-HSA-2033514 8.919913e-01 0.050 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.919913e-01 0.050 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.919913e-01 0.050 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.919913e-01 0.050 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.923675e-01 0.049 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.923675e-01 0.049 0 0
Organic anion transport by SLCO transporters R-HSA-879518 8.923675e-01 0.049 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.923675e-01 0.049 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 8.940023e-01 0.049 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.940023e-01 0.049 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.940023e-01 0.049 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.941502e-01 0.049 0 0
Mitochondrial protein import R-HSA-1268020 8.941502e-01 0.049 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.969856e-01 0.047 0 0
Integration of energy metabolism R-HSA-163685 8.969856e-01 0.047 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.972735e-01 0.047 0 0
Base Excision Repair R-HSA-73884 8.988144e-01 0.046 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.997428e-01 0.046 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.997428e-01 0.046 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.030087e-01 0.044 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.031769e-01 0.044 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.031769e-01 0.044 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.031769e-01 0.044 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.052516e-01 0.043 0 0
Removal of the Flap Intermediate R-HSA-69166 9.052516e-01 0.043 0 0
CRMPs in Sema3A signaling R-HSA-399956 9.052516e-01 0.043 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.052516e-01 0.043 0 0
Transport of fatty acids R-HSA-804914 9.052516e-01 0.043 0 0
Hydrolysis of LPC R-HSA-1483115 9.052516e-01 0.043 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.052516e-01 0.043 0 0
cGMP effects R-HSA-418457 9.052516e-01 0.043 0 0
HDL assembly R-HSA-8963896 9.052516e-01 0.043 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.069797e-01 0.042 0 0
Gene expression (Transcription) R-HSA-74160 9.070087e-01 0.042 0 0
DAP12 interactions R-HSA-2172127 9.077825e-01 0.042 0 0
Surfactant metabolism R-HSA-5683826 9.077825e-01 0.042 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.101148e-01 0.041 0 0
G protein gated Potassium channels R-HSA-1296059 9.126602e-01 0.040 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.126602e-01 0.040 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.126602e-01 0.040 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.126602e-01 0.040 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.126602e-01 0.040 0 0
Formation of the nephric duct R-HSA-9830364 9.126602e-01 0.040 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.151220e-01 0.039 0 0
Protein ubiquitination R-HSA-8852135 9.160016e-01 0.038 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.168847e-01 0.038 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.168847e-01 0.038 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.168847e-01 0.038 0 0
Processive synthesis on the lagging strand R-HSA-69183 9.168847e-01 0.038 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.168847e-01 0.038 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 9.168847e-01 0.038 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 9.168847e-01 0.038 0 0
Protein lipoylation R-HSA-9857492 9.168847e-01 0.038 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 9.168847e-01 0.038 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 9.168847e-01 0.038 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 9.168847e-01 0.038 0 0
DNA Damage Reversal R-HSA-73942 9.168847e-01 0.038 0 0
Selenocysteine synthesis R-HSA-2408557 9.188857e-01 0.037 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.199319e-01 0.036 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 9.202861e-01 0.036 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.208036e-01 0.036 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.214045e-01 0.036 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.214045e-01 0.036 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.214045e-01 0.036 0 0
TCR signaling R-HSA-202403 9.221193e-01 0.035 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.265471e-01 0.033 0 0
Degradation of DVL R-HSA-4641258 9.265471e-01 0.033 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.270900e-01 0.033 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.270900e-01 0.033 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.270900e-01 0.033 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.270900e-01 0.033 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.270900e-01 0.033 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 9.270900e-01 0.033 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.270900e-01 0.033 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.270900e-01 0.033 0 0
Fructose catabolism R-HSA-70350 9.270900e-01 0.033 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.270900e-01 0.033 0 0
Attachment and Entry R-HSA-9678110 9.270900e-01 0.033 0 0
Viral mRNA Translation R-HSA-192823 9.280920e-01 0.032 0 0
Synthesis of PC R-HSA-1483191 9.282531e-01 0.032 0 0
Insulin processing R-HSA-264876 9.293190e-01 0.032 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.309861e-01 0.031 0 0
Transcription of the HIV genome R-HSA-167172 9.312286e-01 0.031 0 0
PCP/CE pathway R-HSA-4086400 9.317038e-01 0.031 0 0
Opioid Signalling R-HSA-111885 9.323486e-01 0.030 0 0
Immune System R-HSA-168256 9.333458e-01 0.030 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.346827e-01 0.029 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.360429e-01 0.029 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.360429e-01 0.029 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.360429e-01 0.029 0 0
Heme assimilation R-HSA-9927020 9.360429e-01 0.029 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.360429e-01 0.029 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.360429e-01 0.029 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 9.364755e-01 0.029 0 0
Formation of the Early Elongation Complex R-HSA-113418 9.364755e-01 0.029 0 0
Inflammasomes R-HSA-622312 9.364755e-01 0.029 0 0
Cell-cell junction organization R-HSA-421270 9.405182e-01 0.027 0 0
RNA Polymerase II Transcription R-HSA-73857 9.406524e-01 0.027 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.407446e-01 0.027 0 0
Ribosome-associated quality control R-HSA-9948299 9.419867e-01 0.026 0 0
mRNA Capping R-HSA-72086 9.429408e-01 0.026 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.438968e-01 0.025 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.438968e-01 0.025 0 0
Glycogen storage diseases R-HSA-3229121 9.438968e-01 0.025 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 9.438968e-01 0.025 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.438968e-01 0.025 0 0
Catecholamine biosynthesis R-HSA-209905 9.438968e-01 0.025 0 0
Uptake and function of anthrax toxins R-HSA-5210891 9.438968e-01 0.025 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.445300e-01 0.025 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.445300e-01 0.025 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.446320e-01 0.025 0 0
Glycogen metabolism R-HSA-8982491 9.446320e-01 0.025 0 0
Generation of second messenger molecules R-HSA-202433 9.446320e-01 0.025 0 0
Collagen degradation R-HSA-1442490 9.463420e-01 0.024 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.487766e-01 0.023 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.496762e-01 0.022 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.507867e-01 0.022 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.507867e-01 0.022 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.507867e-01 0.022 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.507867e-01 0.022 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.507867e-01 0.022 0 0
Generic Transcription Pathway R-HSA-212436 9.510817e-01 0.022 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.528213e-01 0.021 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.534252e-01 0.021 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.534252e-01 0.021 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.534252e-01 0.021 0 0
Orc1 removal from chromatin R-HSA-68949 9.534252e-01 0.021 0 0
Cargo concentration in the ER R-HSA-5694530 9.540401e-01 0.020 0 0
Aspartate and asparagine metabolism R-HSA-8963693 9.540401e-01 0.020 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.542892e-01 0.020 0 0
HIV Transcription Initiation R-HSA-167161 9.542892e-01 0.020 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.542892e-01 0.020 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.542892e-01 0.020 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.542892e-01 0.020 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.542892e-01 0.020 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.542892e-01 0.020 0 0
Viral Infection Pathways R-HSA-9824446 9.546850e-01 0.020 0 0
Signaling by NOTCH4 R-HSA-9013694 9.563234e-01 0.019 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 9.568308e-01 0.019 0 0
Pyrimidine biosynthesis R-HSA-500753 9.568308e-01 0.019 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.568308e-01 0.019 0 0
Diseases of hemostasis R-HSA-9671793 9.568308e-01 0.019 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.568308e-01 0.019 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.573620e-01 0.019 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.577399e-01 0.019 0 0
Activation of GABAB receptors R-HSA-991365 9.585042e-01 0.018 0 0
GABA B receptor activation R-HSA-977444 9.585042e-01 0.018 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.608913e-01 0.017 0 0
Mitochondrial protein degradation R-HSA-9837999 9.613039e-01 0.017 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 9.621329e-01 0.017 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.621329e-01 0.017 0 0
Creatine metabolism R-HSA-71288 9.621329e-01 0.017 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.621329e-01 0.017 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.621329e-01 0.017 0 0
Protein hydroxylation R-HSA-9629569 9.621329e-01 0.017 0 0
Signaling by NODAL R-HSA-1181150 9.621329e-01 0.017 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.623523e-01 0.017 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.623523e-01 0.017 0 0
UCH proteinases R-HSA-5689603 9.626296e-01 0.017 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.630559e-01 0.016 0 0
PPARA activates gene expression R-HSA-1989781 9.643217e-01 0.016 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 9.643285e-01 0.016 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.658627e-01 0.015 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.667840e-01 0.015 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.667840e-01 0.015 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.667840e-01 0.015 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.667840e-01 0.015 0 0
Basigin interactions R-HSA-210991 9.667840e-01 0.015 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.667840e-01 0.015 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.669007e-01 0.015 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.669007e-01 0.015 0 0
Heme degradation R-HSA-189483 9.669007e-01 0.015 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.681898e-01 0.014 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.690626e-01 0.014 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.690626e-01 0.014 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.690626e-01 0.014 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.690626e-01 0.014 0 0
SLC transporter disorders R-HSA-5619102 9.692052e-01 0.014 0 0
Mitophagy R-HSA-5205647 9.703586e-01 0.013 0 0
Signaling by NOTCH2 R-HSA-1980145 9.703586e-01 0.013 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.708641e-01 0.013 0 0
Serine metabolism R-HSA-977347 9.708641e-01 0.013 0 0
Glutathione synthesis and recycling R-HSA-174403 9.708641e-01 0.013 0 0
Attachment and Entry R-HSA-9694614 9.708641e-01 0.013 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.719773e-01 0.012 0 0
Potential therapeutics for SARS R-HSA-9679191 9.725828e-01 0.012 0 0
Regulation of insulin secretion R-HSA-422356 9.730253e-01 0.012 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.734668e-01 0.012 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.734668e-01 0.012 0 0
Downstream TCR signaling R-HSA-202424 9.737339e-01 0.012 0 0
Cellular hexose transport R-HSA-189200 9.744433e-01 0.011 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.746304e-01 0.011 0 0
COPII-mediated vesicle transport R-HSA-204005 9.746614e-01 0.011 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.746614e-01 0.011 0 0
Triglyceride metabolism R-HSA-8979227 9.751984e-01 0.011 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 9.762588e-01 0.010 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.762588e-01 0.010 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.762588e-01 0.010 0 0
ABC-family proteins mediated transport R-HSA-382556 9.767278e-01 0.010 0 0
RAB geranylgeranylation R-HSA-8873719 9.773822e-01 0.010 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.775829e-01 0.010 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.775829e-01 0.010 0 0
Biosynthesis of maresins R-HSA-9018682 9.775829e-01 0.010 0 0
Carnitine shuttle R-HSA-200425 9.775829e-01 0.010 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.775829e-01 0.010 0 0
Degradation of AXIN R-HSA-4641257 9.787655e-01 0.009 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.787655e-01 0.009 0 0
Metabolism of folate and pterines R-HSA-196757 9.787655e-01 0.009 0 0
Collagen chain trimerization R-HSA-8948216 9.787655e-01 0.009 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.792374e-01 0.009 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.793839e-01 0.009 0 0
Aquaporin-mediated transport R-HSA-445717 9.793839e-01 0.009 0 0
CYP2E1 reactions R-HSA-211999 9.803370e-01 0.009 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.803370e-01 0.009 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.803370e-01 0.009 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.803370e-01 0.009 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.803370e-01 0.009 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.803370e-01 0.009 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.810148e-01 0.008 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.812176e-01 0.008 0 0
Tight junction interactions R-HSA-420029 9.827529e-01 0.008 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.827529e-01 0.008 0 0
Laminin interactions R-HSA-3000157 9.827529e-01 0.008 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.830321e-01 0.007 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.830321e-01 0.007 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.830395e-01 0.007 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.833848e-01 0.007 0 0
Developmental Biology R-HSA-1266738 9.846225e-01 0.007 1 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.848405e-01 0.007 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.848405e-01 0.007 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.848405e-01 0.007 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.848721e-01 0.007 0 0
Urea cycle R-HSA-70635 9.848721e-01 0.007 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.848721e-01 0.007 0 0
Cellular response to hypoxia R-HSA-1234174 9.858367e-01 0.006 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.864608e-01 0.006 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.867310e-01 0.006 0 0
Signaling by BMP R-HSA-201451 9.867310e-01 0.006 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.867310e-01 0.006 0 0
G alpha (s) signalling events R-HSA-418555 9.871466e-01 0.006 0 0
Synthesis of DNA R-HSA-69239 9.873317e-01 0.006 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.874402e-01 0.005 0 0
Cholesterol biosynthesis R-HSA-191273 9.874402e-01 0.005 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 9.875190e-01 0.005 0 0
DNA Replication R-HSA-69306 9.878060e-01 0.005 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.879119e-01 0.005 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.880967e-01 0.005 0 0
Metabolism of steroid hormones R-HSA-196071 9.882922e-01 0.005 0 0
Nicotinate metabolism R-HSA-196807 9.882922e-01 0.005 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.883615e-01 0.005 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.883615e-01 0.005 0 0
Insulin receptor recycling R-HSA-77387 9.883615e-01 0.005 0 0
G alpha (z) signalling events R-HSA-418597 9.887411e-01 0.005 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.891565e-01 0.005 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.892109e-01 0.005 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.897918e-01 0.004 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.897918e-01 0.004 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.903733e-01 0.004 0 0
Amyloid fiber formation R-HSA-977225 9.904176e-01 0.004 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.910464e-01 0.004 0 0
Proteasome assembly R-HSA-9907900 9.914130e-01 0.004 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.921469e-01 0.003 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.921469e-01 0.003 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.921469e-01 0.003 0 0
Nucleosome assembly R-HSA-774815 9.923427e-01 0.003 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.923427e-01 0.003 0 0
Somitogenesis R-HSA-9824272 9.923427e-01 0.003 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.923427e-01 0.003 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.925732e-01 0.003 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.931121e-01 0.003 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.931736e-01 0.003 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.931736e-01 0.003 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.931736e-01 0.003 0 0
Glutathione conjugation R-HSA-156590 9.933130e-01 0.003 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.933130e-01 0.003 0 0
Recycling of bile acids and salts R-HSA-159418 9.939588e-01 0.003 0 0
Endogenous sterols R-HSA-211976 9.939812e-01 0.003 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 9.945791e-01 0.002 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.951711e-01 0.002 0 0
eNOS activation R-HSA-203615 9.953528e-01 0.002 0 0
Signal amplification R-HSA-392518 9.953528e-01 0.002 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.953528e-01 0.002 0 0
RA biosynthesis pathway R-HSA-5365859 9.953528e-01 0.002 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.953528e-01 0.002 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.956199e-01 0.002 0 0
ER-Phagosome pathway R-HSA-1236974 9.958340e-01 0.002 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.959242e-01 0.002 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.959242e-01 0.002 0 0
Regulation of Apoptosis R-HSA-169911 9.959242e-01 0.002 0 0
Integrin cell surface interactions R-HSA-216083 9.960067e-01 0.002 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.961711e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.962092e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.963865e-01 0.002 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.964619e-01 0.002 0 0
tRNA processing R-HSA-72306 9.965014e-01 0.002 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.965918e-01 0.001 0 0
NCAM1 interactions R-HSA-419037 9.968648e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.969669e-01 0.001 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.971455e-01 0.001 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.971497e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.972503e-01 0.001 0 0
Purine salvage R-HSA-74217 9.972503e-01 0.001 0 0
Protein localization R-HSA-9609507 9.972527e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.972935e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.974090e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.975851e-01 0.001 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.975885e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.975885e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.975994e-01 0.001 0 0
Collagen formation R-HSA-1474290 9.976470e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.978650e-01 0.001 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.978850e-01 0.001 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.978850e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.981015e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.981015e-01 0.001 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.981451e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.981451e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.981811e-01 0.001 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.983381e-01 0.001 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.983392e-01 0.001 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.984999e-01 0.001 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.985734e-01 0.001 0 0
Metabolism of steroids R-HSA-8957322 9.986142e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.986210e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.986859e-01 0.001 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.986903e-01 0.001 0 0
Defensins R-HSA-1461973 9.987489e-01 0.001 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.988402e-01 0.001 0 0
Selenoamino acid metabolism R-HSA-2408522 9.988418e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.988491e-01 0.001 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.988548e-01 0.000 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.989028e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.989028e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.990399e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.990399e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.990399e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.990654e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.990924e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.991402e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.991700e-01 0.000 0 0
Neddylation R-HSA-8951664 9.992032e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.992887e-01 0.000 0 0
Kidney development R-HSA-9830369 9.994193e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.994193e-01 0.000 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.994309e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.994317e-01 0.000 0 0
Leishmania phagocytosis R-HSA-9664417 9.994845e-01 0.000 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.994845e-01 0.000 0 0
Parasite infection R-HSA-9664407 9.994845e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.994846e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.995009e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.996401e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.996401e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.996401e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.996480e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.996721e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.996752e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.996808e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.996845e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.997169e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.997202e-01 0.000 0 0
Digestion R-HSA-8935690 9.997730e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.997774e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.998470e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.998658e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.998658e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.998782e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.998823e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.998887e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998922e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.998951e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999095e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999129e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999465e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999681e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.999684e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.999684e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999684e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999723e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999730e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.999787e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999787e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999809e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.999819e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.999819e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999857e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999865e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999879e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999880e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999887e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999915e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999929e-01 0.000 0 0
Translation R-HSA-72766 9.999953e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999961e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999961e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999964e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999970e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999978e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999992e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999994e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999994e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999995e-01 0.000 0 0
Disease R-HSA-1643685 9.999996e-01 0.000 1 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999997e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999997e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999997e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999998e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999998e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999998e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999998e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999999e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999999e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999999e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Post-translational protein modification R-HSA-597592 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Attenuation phase R-HSA-3371568 9.508949e-12 11.022 0 0
Cellular response to heat stress R-HSA-3371556 1.189637e-11 10.925 0 0
Cellular responses to stimuli R-HSA-8953897 1.375122e-11 10.862 0 0
Cellular responses to stress R-HSA-2262752 2.177392e-11 10.662 0 0
Apoptotic execution phase R-HSA-75153 3.136358e-11 10.504 0 0
HSF1-dependent transactivation R-HSA-3371571 4.028933e-11 10.395 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.459844e-11 10.351 0 0
Interleukin-12 signaling R-HSA-9020591 2.812314e-10 9.551 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.410036e-10 9.267 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.295392e-09 8.888 0 0
Interleukin-12 family signaling R-HSA-447115 1.672333e-09 8.777 0 0
HSF1 activation R-HSA-3371511 1.858420e-09 8.731 0 0
Apoptosis R-HSA-109581 8.944718e-07 6.048 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.365419e-06 5.270 0 0
Programmed Cell Death R-HSA-5357801 6.645956e-06 5.177 0 0
Cell Cycle R-HSA-1640170 7.408933e-06 5.130 0 0
Cell Cycle, Mitotic R-HSA-69278 8.909242e-06 5.050 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.101221e-05 4.958 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.096333e-05 4.679 1 1
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.096333e-05 4.679 1 1
Signaling downstream of RAS mutants R-HSA-9649948 2.096333e-05 4.679 1 1
Signaling by RAS mutants R-HSA-6802949 2.096333e-05 4.679 1 0
Metabolism of RNA R-HSA-8953854 2.349590e-05 4.629 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.078614e-05 4.389 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.246060e-05 4.372 0 0
Chromatin organization R-HSA-4839726 5.195267e-05 4.284 0 0
Signaling by Hippo R-HSA-2028269 5.661708e-05 4.247 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.741830e-05 4.241 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.241522e-05 4.205 0 0
Eukaryotic Translation Initiation R-HSA-72613 6.178790e-05 4.209 0 0
Cap-dependent Translation Initiation R-HSA-72737 6.178790e-05 4.209 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.473794e-05 4.189 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.485772e-05 4.071 1 1
Signaling by BRAF and RAF1 fusions R-HSA-6802952 8.815886e-05 4.055 1 1
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 8.791325e-05 4.056 0 0
Axon guidance R-HSA-422475 8.919150e-05 4.050 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.711841e-05 4.013 1 1
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.011247e-04 3.995 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.011247e-04 3.995 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.004964e-04 3.998 1 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.643691e-04 3.784 0 0
Nervous system development R-HSA-9675108 1.612607e-04 3.792 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.713611e-04 3.766 0 0
Cell-Cell communication R-HSA-1500931 2.251105e-04 3.648 0 0
M Phase R-HSA-68886 2.312717e-04 3.636 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.435528e-04 3.613 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.401062e-04 3.620 0 0
Folding of actin by CCT/TriC R-HSA-390450 2.657360e-04 3.576 0 0
MAP2K and MAPK activation R-HSA-5674135 2.871369e-04 3.542 1 1
Regulation of PTEN gene transcription R-HSA-8943724 3.185991e-04 3.497 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.185991e-04 3.497 0 0
Translation initiation complex formation R-HSA-72649 3.357447e-04 3.474 0 0
mRNA Splicing - Major Pathway R-HSA-72163 3.438852e-04 3.464 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.993448e-04 3.399 0 0
HDACs deacetylate histones R-HSA-3214815 3.983604e-04 3.400 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.057489e-04 3.392 0 0
Chromatin modifying enzymes R-HSA-3247509 3.867576e-04 3.413 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.121844e-04 3.385 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.702281e-04 3.328 1 0
Striated Muscle Contraction R-HSA-390522 4.977666e-04 3.303 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.977666e-04 3.303 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.772631e-04 3.239 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.820886e-04 3.235 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.169305e-04 3.210 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 6.303997e-04 3.200 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 6.499781e-04 3.187 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.500692e-04 3.187 0 0
G2/M Transition R-HSA-69275 6.589413e-04 3.181 0 0
Signaling by ROBO receptors R-HSA-376176 7.230202e-04 3.141 0 0
PKMTs methylate histone lysines R-HSA-3214841 7.567056e-04 3.121 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 8.046163e-04 3.094 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.771769e-04 3.109 0 0
Signal Transduction R-HSA-162582 7.844717e-04 3.105 1 0
Smooth Muscle Contraction R-HSA-445355 8.202642e-04 3.086 0 0
mRNA Splicing R-HSA-72172 8.458056e-04 3.073 0 0
Kinesins R-HSA-983189 8.844640e-04 3.053 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 8.465046e-04 3.072 0 0
Membrane Trafficking R-HSA-199991 1.037949e-03 2.984 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.090403e-03 2.962 0 0
Mitotic Prophase R-HSA-68875 1.141212e-03 2.943 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.308380e-03 2.883 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.301585e-03 2.886 0 0
Influenza Infection R-HSA-168255 1.355306e-03 2.868 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.575612e-03 2.803 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.615802e-03 2.792 0 0
L1CAM interactions R-HSA-373760 1.619873e-03 2.791 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.615802e-03 2.792 0 0
Polo-like kinase mediated events R-HSA-156711 1.685179e-03 2.773 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.734851e-03 2.761 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.924870e-03 2.716 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.924870e-03 2.716 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.819236e-03 2.740 0 0
Protein folding R-HSA-391251 1.939651e-03 2.712 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.939651e-03 2.712 0 0
RAF activation R-HSA-5673000 2.003279e-03 2.698 1 1
PKR-mediated signaling R-HSA-9833482 2.042092e-03 2.690 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.064380e-03 2.685 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.118604e-03 2.674 0 0
Mitotic Prometaphase R-HSA-68877 2.132404e-03 2.671 0 0
Viral Infection Pathways R-HSA-9824446 2.224791e-03 2.653 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.196635e-03 2.658 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.239568e-03 2.650 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.349816e-03 2.629 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.352659e-03 2.628 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.404684e-03 2.619 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.460397e-03 2.609 0 0
Cell junction organization R-HSA-446728 2.524955e-03 2.598 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.724934e-03 2.565 0 0
HIV Life Cycle R-HSA-162587 2.761208e-03 2.559 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.980189e-03 2.526 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.980189e-03 2.526 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.981947e-03 2.526 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.981947e-03 2.526 0 0
SARS-CoV Infections R-HSA-9679506 3.014523e-03 2.521 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.296590e-03 2.482 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.296590e-03 2.482 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.183185e-03 2.497 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 3.183185e-03 2.497 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.402445e-03 2.468 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 3.460687e-03 2.461 0 0
Meiosis R-HSA-1500620 3.611958e-03 2.442 0 0
Mitotic Anaphase R-HSA-68882 3.579360e-03 2.446 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.657622e-03 2.437 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.820268e-03 2.418 0 0
Regulation of CDH1 Function R-HSA-9764561 3.911794e-03 2.408 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.912285e-03 2.408 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.912285e-03 2.408 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.012816e-03 2.397 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 4.068968e-03 2.391 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.094990e-03 2.388 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.516186e-03 2.345 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.450197e-03 2.352 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 4.287952e-03 2.368 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.312471e-03 2.365 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.673117e-03 2.330 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.287952e-03 2.368 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.450197e-03 2.352 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 4.787454e-03 2.320 0 0
G2/M Checkpoints R-HSA-69481 4.805129e-03 2.318 0 0
Glycolysis R-HSA-70171 4.885232e-03 2.311 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 5.023310e-03 2.299 0 0
snRNP Assembly R-HSA-191859 5.059605e-03 2.296 0 0
Metabolism of non-coding RNA R-HSA-194441 5.059605e-03 2.296 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.091238e-03 2.293 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.185824e-03 2.285 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 5.778473e-03 2.238 0 0
Peptide chain elongation R-HSA-156902 5.493092e-03 2.260 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.498989e-03 2.260 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.626550e-03 2.250 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 5.494067e-03 2.260 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 5.494067e-03 2.260 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.727627e-03 2.242 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.778473e-03 2.238 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.335783e-03 2.273 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.335783e-03 2.273 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.830134e-03 2.234 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.005858e-03 2.221 0 0
Nuclear import of Rev protein R-HSA-180746 6.007889e-03 2.221 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.380844e-03 2.195 0 0
Late endosomal microautophagy R-HSA-9615710 6.431479e-03 2.192 0 0
Ephrin signaling R-HSA-3928664 6.530395e-03 2.185 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 6.530395e-03 2.185 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.530395e-03 2.185 0 0
Recycling pathway of L1 R-HSA-437239 6.548715e-03 2.184 0 0
Interferon Signaling R-HSA-913531 6.617873e-03 2.179 0 0
SARS-CoV-2 Infection R-HSA-9694516 6.865058e-03 2.163 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.048176e-03 2.152 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.058278e-03 2.151 0 0
Ribosome-associated quality control R-HSA-9948299 7.127135e-03 2.147 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 8.069164e-03 2.093 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 7.538151e-03 2.123 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 7.852352e-03 2.105 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 8.069164e-03 2.093 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.852352e-03 2.105 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.375540e-03 2.132 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.376069e-03 2.132 0 0
CaM pathway R-HSA-111997 8.222617e-03 2.085 0 0
Calmodulin induced events R-HSA-111933 8.222617e-03 2.085 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.305696e-03 2.081 0 0
Ca-dependent events R-HSA-111996 8.488263e-03 2.071 0 0
Cellular Senescence R-HSA-2559583 8.533701e-03 2.069 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.029072e-03 2.044 0 0
Cell Cycle Checkpoints R-HSA-69620 9.380481e-03 2.028 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 9.654612e-03 2.015 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 9.714195e-03 2.013 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.000764e-02 2.000 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.005382e-02 1.998 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.026942e-02 1.988 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.028414e-02 1.988 0 0
Post NMDA receptor activation events R-HSA-438064 1.045720e-02 1.981 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.062478e-02 1.974 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.067460e-02 1.972 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.146704e-02 1.941 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.167861e-02 1.933 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.172732e-02 1.931 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.235173e-02 1.908 0 0
HIV Infection R-HSA-162906 1.159375e-02 1.936 0 0
Muscle contraction R-HSA-397014 1.323842e-02 1.878 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.235173e-02 1.908 0 0
Meiotic synapsis R-HSA-1221632 1.385408e-02 1.858 0 0
MAPK family signaling cascades R-HSA-5683057 1.424282e-02 1.846 1 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.428182e-02 1.845 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.431919e-02 1.844 0 0
Aggrephagy R-HSA-9646399 1.447751e-02 1.839 0 0
Separation of Sister Chromatids R-HSA-2467813 1.453909e-02 1.837 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.467091e-02 1.834 0 0
Neutrophil degranulation R-HSA-6798695 1.472262e-02 1.832 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.479001e-02 1.830 0 0
Autophagy R-HSA-9612973 1.499056e-02 1.824 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.502007e-02 1.823 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.513745e-02 1.820 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.518625e-02 1.819 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.539182e-02 1.813 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.648481e-02 1.783 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.650876e-02 1.782 0 0
Platelet degranulation R-HSA-114608 1.664627e-02 1.779 0 0
Cellular response to starvation R-HSA-9711097 1.700520e-02 1.769 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.728108e-02 1.762 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.062577e-02 1.686 0 0
Type I hemidesmosome assembly R-HSA-446107 2.062577e-02 1.686 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 2.062577e-02 1.686 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 2.062577e-02 1.686 0 0
Formation of annular gap junctions R-HSA-196025 2.062577e-02 1.686 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 2.062577e-02 1.686 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.849055e-02 1.733 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.810955e-02 1.742 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.932603e-02 1.714 0 0
Regulation of TP53 Activity R-HSA-5633007 1.922861e-02 1.716 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.062577e-02 1.686 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 2.059248e-02 1.686 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.790623e-02 1.747 0 0
MHC class II antigen presentation R-HSA-2132295 2.098255e-02 1.678 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.190710e-02 1.659 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.192343e-02 1.659 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.237012e-02 1.650 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 2.257560e-02 1.646 0 0
Diseases of programmed cell death R-HSA-9645723 2.273669e-02 1.643 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 2.288873e-02 1.640 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.419082e-02 1.616 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.429333e-02 1.615 0 0
Neurodegenerative Diseases R-HSA-8863678 2.429333e-02 1.615 0 0
Eukaryotic Translation Termination R-HSA-72764 2.439889e-02 1.613 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.454037e-02 1.610 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.467183e-02 1.608 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.467183e-02 1.608 0 0
Glucose metabolism R-HSA-70326 2.468832e-02 1.608 0 0
Signaling by VEGF R-HSA-194138 2.566757e-02 1.591 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.586091e-02 1.587 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.660610e-02 1.575 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.697644e-02 1.569 1 0
Gap junction degradation R-HSA-190873 2.719371e-02 1.566 0 0
mRNA 3'-end processing R-HSA-72187 2.797490e-02 1.553 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.799126e-02 1.553 0 0
Adherens junctions interactions R-HSA-418990 2.866985e-02 1.543 0 0
IRS activation R-HSA-74713 2.868124e-02 1.542 0 0
DAG and IP3 signaling R-HSA-1489509 2.970924e-02 1.527 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.970924e-02 1.527 0 0
Deubiquitination R-HSA-5688426 2.996193e-02 1.523 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.258472e-02 1.487 0 0
Nephrin family interactions R-HSA-373753 3.169229e-02 1.499 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.442244e-02 1.463 0 0
RNA Polymerase I Transcription R-HSA-73864 3.458553e-02 1.461 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.218516e-02 1.492 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.258472e-02 1.487 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.467115e-02 1.460 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.606430e-02 1.443 1 0
Protein methylation R-HSA-8876725 3.442244e-02 1.463 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.442244e-02 1.463 0 0
Cell-cell junction organization R-HSA-421270 3.748915e-02 1.426 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 3.754680e-02 1.425 0 0
Death Receptor Signaling R-HSA-73887 3.704213e-02 1.431 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.425879e-02 1.465 0 0
Signaling by ALK in cancer R-HSA-9700206 3.425879e-02 1.465 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 3.314073e-02 1.480 0 0
Selenocysteine synthesis R-HSA-2408557 3.775107e-02 1.423 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.783168e-02 1.422 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 3.790185e-02 1.421 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 3.790185e-02 1.421 0 0
Host Interactions of HIV factors R-HSA-162909 3.883608e-02 1.411 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 4.002618e-02 1.398 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.002618e-02 1.398 0 0
PTEN Regulation R-HSA-6807070 4.033034e-02 1.394 0 0
Unfolded Protein Response (UPR) R-HSA-381119 4.033034e-02 1.394 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 4.121295e-02 1.385 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.127400e-02 1.384 0 0
Vesicle-mediated transport R-HSA-5653656 4.164235e-02 1.380 0 0
Selective autophagy R-HSA-9663891 4.273247e-02 1.369 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.284632e-02 1.368 0 0
Viral mRNA Translation R-HSA-192823 4.320254e-02 1.364 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 4.459326e-02 1.351 0 0
Gap junction trafficking and regulation R-HSA-157858 4.467908e-02 1.350 0 0
Gene expression (Transcription) R-HSA-74160 4.571791e-02 1.340 0 0
Opioid Signalling R-HSA-111885 4.613013e-02 1.336 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.629530e-02 1.334 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.822333e-02 1.317 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.885302e-02 1.311 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.900698e-02 1.310 0 0
Disorders of Developmental Biology R-HSA-9675151 4.900698e-02 1.310 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.900698e-02 1.310 0 0
FGFR2 alternative splicing R-HSA-6803529 4.987603e-02 1.302 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.453168e-02 1.263 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 5.453168e-02 1.263 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.453168e-02 1.263 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.453168e-02 1.263 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.453168e-02 1.263 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.453168e-02 1.263 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.453168e-02 1.263 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.453168e-02 1.263 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.453168e-02 1.263 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.453168e-02 1.263 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.453168e-02 1.263 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.453168e-02 1.263 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.364676e-02 1.270 0 0
RET signaling R-HSA-8853659 5.169998e-02 1.287 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.879084e-02 1.231 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.314604e-02 1.200 0 0
HCMV Early Events R-HSA-9609690 5.300573e-02 1.276 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.879084e-02 1.231 0 0
Protein ubiquitination R-HSA-8852135 5.191717e-02 1.285 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.364676e-02 1.270 0 0
PLC beta mediated events R-HSA-112043 6.314604e-02 1.200 0 0
G-protein mediated events R-HSA-112040 5.293947e-02 1.276 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.593339e-02 1.252 0 0
HCMV Infection R-HSA-9609646 5.276153e-02 1.278 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 5.364676e-02 1.270 0 0
Gap junction trafficking R-HSA-190828 5.864634e-02 1.232 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.330031e-02 1.273 0 0
Cellular response to chemical stress R-HSA-9711123 5.161744e-02 1.287 0 0
Cilium Assembly R-HSA-5617833 6.097860e-02 1.215 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.749477e-02 1.240 0 0
rRNA processing R-HSA-72312 5.380581e-02 1.269 0 0
Reproduction R-HSA-1474165 6.140777e-02 1.212 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.239887e-02 1.281 1 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.191717e-02 1.285 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 5.191717e-02 1.285 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.800127e-02 1.237 0 0
Interleukin-37 signaling R-HSA-9008059 5.483602e-02 1.261 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.407364e-02 1.193 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 6.407364e-02 1.193 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.436088e-02 1.191 0 0
Regulation of IFNG signaling R-HSA-877312 6.472173e-02 1.189 0 0
Disorders of Nervous System Development R-HSA-9697154 6.472173e-02 1.189 0 0
Pervasive developmental disorders R-HSA-9005895 6.472173e-02 1.189 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 6.472173e-02 1.189 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.480486e-02 1.188 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.494007e-02 1.187 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.504551e-02 1.187 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.672538e-02 1.176 0 0
Platelet sensitization by LDL R-HSA-432142 6.672538e-02 1.176 0 0
tRNA processing in the nucleus R-HSA-6784531 6.829929e-02 1.166 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.840534e-02 1.165 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.840534e-02 1.165 0 0
Macroautophagy R-HSA-1632852 7.185246e-02 1.144 0 0
Translation R-HSA-72766 7.207584e-02 1.142 0 0
Signaling by Interleukins R-HSA-449147 7.328650e-02 1.135 0 0
Potential therapeutics for SARS R-HSA-9679191 7.522218e-02 1.124 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.552894e-02 1.122 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.639004e-02 1.117 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.639004e-02 1.117 0 0
Rap1 signalling R-HSA-392517 7.675523e-02 1.115 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.681427e-02 1.115 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.689249e-02 1.114 0 0
FasL/ CD95L signaling R-HSA-75157 8.024995e-02 1.096 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 8.229614e-02 1.085 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.239013e-02 1.084 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.465491e-02 1.072 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 8.521535e-02 1.069 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 8.596100e-02 1.066 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.752956e-02 1.058 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 8.755011e-02 1.058 0 0
Signal transduction by L1 R-HSA-445144 8.755011e-02 1.058 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 8.755011e-02 1.058 0 0
Drug resistance of KIT mutants R-HSA-9669937 8.911584e-02 1.050 0 0
KIT mutants bind TKIs R-HSA-9669921 8.911584e-02 1.050 0 0
Nilotinib-resistant KIT mutants R-HSA-9669926 8.911584e-02 1.050 0 0
Sorafenib-resistant KIT mutants R-HSA-9669936 8.911584e-02 1.050 0 0
Sunitinib-resistant KIT mutants R-HSA-9669934 8.911584e-02 1.050 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.911584e-02 1.050 0 0
Masitinib-resistant KIT mutants R-HSA-9669924 8.911584e-02 1.050 0 0
Imatinib-resistant KIT mutants R-HSA-9669917 8.911584e-02 1.050 0 0
Regorafenib-resistant KIT mutants R-HSA-9669929 8.911584e-02 1.050 0 0
Dasatinib-resistant KIT mutants R-HSA-9669914 8.911584e-02 1.050 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 9.012068e-02 1.045 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.199998e-02 1.036 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.244614e-02 1.034 1 1
Regulation of gap junction activity R-HSA-191650 1.088940e-01 0.963 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.088940e-01 0.963 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.035851e-01 0.985 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 1.195469e-01 0.922 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.195469e-01 0.922 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.113541e-01 0.953 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.113541e-01 0.953 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.315600e-02 1.031 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.118041e-01 0.952 0 0
Centrosome maturation R-HSA-380287 9.397855e-02 1.027 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.077467e-01 0.968 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.077467e-01 0.968 0 0
EPH-Ephrin signaling R-HSA-2682334 1.024363e-01 0.990 0 0
HATs acetylate histones R-HSA-3214847 9.737207e-02 1.012 0 0
Josephin domain DUBs R-HSA-5689877 1.233570e-01 0.909 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.233570e-01 0.909 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.043578e-01 0.981 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 1.020388e-01 0.991 0 0
G1/S Transition R-HSA-69206 1.122997e-01 0.950 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.118041e-01 0.952 0 0
Prolonged ERK activation events R-HSA-169893 1.195469e-01 0.922 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.035851e-01 0.985 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.233570e-01 0.909 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.043578e-01 0.981 0 0
Meiotic recombination R-HSA-912446 1.058369e-01 0.975 0 0
ESR-mediated signaling R-HSA-8939211 9.364938e-02 1.028 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.035851e-01 0.985 0 0
Signal attenuation R-HSA-74749 1.233570e-01 0.909 0 0
S Phase R-HSA-69242 1.041959e-01 0.982 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.035851e-01 0.985 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.190769e-01 0.924 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.218135e-01 0.914 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.145287e-01 0.941 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.088940e-01 0.963 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.170851e-01 0.931 0 0
Signaling by TGFB family members R-HSA-9006936 1.166686e-01 0.933 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.139426e-01 0.943 0 0
CASP4 inflammasome assembly R-HSA-9948001 1.233570e-01 0.909 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.135211e-01 0.945 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.113541e-01 0.953 0 0
IRE1alpha activates chaperones R-HSA-381070 9.674522e-02 1.014 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.141184e-01 0.943 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.113541e-01 0.953 0 0
Gene Silencing by RNA R-HSA-211000 9.762682e-02 1.010 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.242382e-01 0.906 0 0
Activation of BH3-only proteins R-HSA-114452 1.242382e-01 0.906 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.242382e-01 0.906 0 0
mTORC1-mediated signalling R-HSA-166208 1.243101e-01 0.905 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.250475e-01 0.903 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.266120e-01 0.898 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.266120e-01 0.898 1 1
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.273639e-01 0.895 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.311459e-01 0.882 0 0
Integration of energy metabolism R-HSA-163685 1.324660e-01 0.878 0 0
Semaphorin interactions R-HSA-373755 1.332973e-01 0.875 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.347454e-01 0.870 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 1.356241e-01 0.868 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.356241e-01 0.868 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.356241e-01 0.868 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.356241e-01 0.868 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.379261e-01 0.860 0 0
Growth hormone receptor signaling R-HSA-982772 1.379261e-01 0.860 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.397388e-01 0.855 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.397388e-01 0.855 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.397388e-01 0.855 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.397388e-01 0.855 0 0
PECAM1 interactions R-HSA-210990 1.443665e-01 0.841 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.443665e-01 0.841 0 0
Signaling by APC mutants R-HSA-4839744 1.443665e-01 0.841 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.443665e-01 0.841 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.443665e-01 0.841 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.443665e-01 0.841 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.473327e-01 0.832 0 0
NRAGE signals death through JNK R-HSA-193648 1.496296e-01 0.825 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.525200e-01 0.817 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.544377e-01 0.811 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.544377e-01 0.811 0 0
Hemostasis R-HSA-109582 1.608966e-01 0.793 0 0
Integrin signaling R-HSA-354192 1.612185e-01 0.793 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.612185e-01 0.793 0 0
Nuclear RNA decay R-HSA-9930044 1.612185e-01 0.793 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.612185e-01 0.793 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.624671e-01 0.789 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.702949e-01 0.769 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.702949e-01 0.769 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.702949e-01 0.769 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.702949e-01 0.769 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 1.702949e-01 0.769 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.702949e-01 0.769 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.702949e-01 0.769 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.702949e-01 0.769 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.702949e-01 0.769 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.702949e-01 0.769 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.702949e-01 0.769 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 2.442435e-01 0.612 0 0
Signaling by juxtamembrane domain KIT mutants R-HSA-9669935 2.442435e-01 0.612 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.442435e-01 0.612 0 0
Signaling by extracellular domain mutants of KIT R-HSA-9680187 2.442435e-01 0.612 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 2.442435e-01 0.612 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 2.442435e-01 0.612 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 2.442435e-01 0.612 0 0
Signaling by kinase domain mutants of KIT R-HSA-9669933 2.442435e-01 0.612 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.442435e-01 0.612 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.442435e-01 0.612 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.442435e-01 0.612 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.442435e-01 0.612 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.442435e-01 0.612 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.721654e-01 0.764 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.721654e-01 0.764 0 0
G2/M DNA replication checkpoint R-HSA-69478 2.056472e-01 0.687 0 0
Signaling by GSK3beta mutants R-HSA-5339716 1.664467e-01 0.779 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 2.397392e-01 0.620 0 0
TRIF-mediated programmed cell death R-HSA-2562578 2.397392e-01 0.620 0 0
Recycling of eIF2:GDP R-HSA-72731 2.397392e-01 0.620 0 0
SOS-mediated signalling R-HSA-112412 2.397392e-01 0.620 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.894317e-01 0.723 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.894317e-01 0.723 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 1.894317e-01 0.723 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 1.894317e-01 0.723 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 1.894317e-01 0.723 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 1.894317e-01 0.723 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 1.894317e-01 0.723 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.884721e-01 0.725 0 0
Regulation of KIT signaling R-HSA-1433559 2.374754e-01 0.624 0 0
Long-term potentiation R-HSA-9620244 1.669873e-01 0.777 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.073743e-01 0.683 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.073743e-01 0.683 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.073743e-01 0.683 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.073743e-01 0.683 0 0
Cristae formation R-HSA-8949613 1.982098e-01 0.703 0 0
HIV elongation arrest and recovery R-HSA-167287 2.145196e-01 0.669 0 0
Pausing and recovery of HIV elongation R-HSA-167290 2.145196e-01 0.669 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.881965e-01 0.725 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.312329e-01 0.636 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.906195e-01 0.720 0 0
G1/S-Specific Transcription R-HSA-69205 2.167723e-01 0.664 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.884893e-01 0.725 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.862698e-01 0.730 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.267897e-01 0.644 0 0
Signaling by SCF-KIT R-HSA-1433557 2.033827e-01 0.692 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.796107e-01 0.746 0 0
DNA Double Strand Break Response R-HSA-5693606 1.690554e-01 0.772 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 1.664467e-01 0.779 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.823503e-01 0.739 0 0
Integration of provirus R-HSA-162592 1.664467e-01 0.779 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 2.267897e-01 0.644 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.982098e-01 0.703 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.146913e-01 0.668 0 0
Transcription of the HIV genome R-HSA-167172 1.786496e-01 0.748 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 2.315826e-01 0.635 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.164618e-01 0.665 0 0
DNA Double-Strand Break Repair R-HSA-5693532 1.838774e-01 0.735 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 2.131599e-01 0.671 0 0
HDMs demethylate histones R-HSA-3214842 1.669873e-01 0.777 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.397392e-01 0.620 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.034221e-01 0.692 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 2.131599e-01 0.671 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.813918e-01 0.741 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.702949e-01 0.769 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 1.669873e-01 0.777 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.701614e-01 0.769 0 0
Developmental Cell Lineages R-HSA-9734767 2.078661e-01 0.682 0 0
Frs2-mediated activation R-HSA-170968 2.131599e-01 0.671 0 0
Protein-protein interactions at synapses R-HSA-6794362 1.665168e-01 0.779 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.721654e-01 0.764 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 1.823503e-01 0.739 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.053580e-01 0.687 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.193860e-01 0.659 0 0
Gap junction assembly R-HSA-190861 1.881965e-01 0.725 0 0
Inhibition of PKR R-HSA-169131 1.702949e-01 0.769 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.442435e-01 0.612 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.442435e-01 0.612 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.664467e-01 0.779 0 0
Signaling by AXIN mutants R-HSA-4839735 1.664467e-01 0.779 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 2.131599e-01 0.671 0 0
Platelet calcium homeostasis R-HSA-418360 2.312329e-01 0.636 0 0
RMTs methylate histone arginines R-HSA-3214858 2.164618e-01 0.665 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 2.397392e-01 0.620 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.778661e-01 0.750 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.721654e-01 0.764 0 0
Nef and signal transduction R-HSA-164944 2.056472e-01 0.687 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 2.374754e-01 0.624 0 0
Basigin interactions R-HSA-210991 2.267897e-01 0.644 0 0
Signaling by NOTCH3 R-HSA-9012852 2.394027e-01 0.621 0 0
TGFBR3 expression R-HSA-9839394 1.669873e-01 0.777 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 2.368396e-01 0.626 0 0
RNA Polymerase II Transcription R-HSA-73857 2.387822e-01 0.622 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.442435e-01 0.612 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.721654e-01 0.764 0 0
Defective pyroptosis R-HSA-9710421 2.033827e-01 0.692 0 0
G alpha (12/13) signalling events R-HSA-416482 1.862698e-01 0.730 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.131599e-01 0.671 0 0
Signal regulatory protein family interactions R-HSA-391160 2.374754e-01 0.624 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 1.721654e-01 0.764 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 2.374754e-01 0.624 0 0
NTRK3 as a dependence receptor R-HSA-9603505 2.442435e-01 0.612 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.397392e-01 0.620 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.721654e-01 0.764 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.397392e-01 0.620 0 0
OAS antiviral response R-HSA-8983711 1.894317e-01 0.723 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 2.073743e-01 0.683 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.701614e-01 0.769 0 0
Selenoamino acid metabolism R-HSA-2408522 1.924559e-01 0.716 0 0
Non-canonical inflammasome activation R-HSA-9686114 2.374754e-01 0.624 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.301095e-01 0.638 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.458566e-01 0.609 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.466402e-01 0.608 0 0
Assembly Of The HIV Virion R-HSA-175474 2.466402e-01 0.608 0 0
Ion homeostasis R-HSA-5578775 2.521055e-01 0.598 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.521055e-01 0.598 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.521055e-01 0.598 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.546160e-01 0.594 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.564114e-01 0.591 0 0
Homology Directed Repair R-HSA-5693538 2.570520e-01 0.590 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.116053e-01 0.506 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.116053e-01 0.506 0 0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) R-HSA-5655799 3.116053e-01 0.506 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.116053e-01 0.506 0 0
Axonal growth stimulation R-HSA-209563 3.729667e-01 0.428 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.729667e-01 0.428 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.729667e-01 0.428 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.729667e-01 0.428 0 0
Regulation by c-FLIP R-HSA-3371378 2.740668e-01 0.562 0 0
Dimerization of procaspase-8 R-HSA-69416 2.740668e-01 0.562 0 0
ARMS-mediated activation R-HSA-170984 3.083177e-01 0.511 0 0
Lipophagy R-HSA-9613354 3.083177e-01 0.511 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.083177e-01 0.511 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 3.083177e-01 0.511 0 0
CASP8 activity is inhibited R-HSA-5218900 3.083177e-01 0.511 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.288619e-01 0.368 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.288619e-01 0.368 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.288619e-01 0.368 0 0
Defective FMO3 causes TMAU R-HSA-5579019 4.288619e-01 0.368 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.288619e-01 0.368 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.288619e-01 0.368 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.622301e-01 0.581 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.622301e-01 0.581 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 2.622301e-01 0.581 0 0
Binding and entry of HIV virion R-HSA-173107 3.422330e-01 0.466 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 3.422330e-01 0.466 0 0
2-LTR circle formation R-HSA-164843 3.422330e-01 0.466 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.422330e-01 0.466 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 2.872849e-01 0.542 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.872849e-01 0.542 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 4.797774e-01 0.319 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.797774e-01 0.319 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 4.797774e-01 0.319 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.377855e-01 0.471 0 0
Deadenylation of mRNA R-HSA-429947 3.080431e-01 0.511 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.080431e-01 0.511 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.082488e-01 0.389 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.082488e-01 0.389 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 3.630021e-01 0.440 0 0
PKA activation R-HSA-163615 3.630021e-01 0.440 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.288856e-01 0.483 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.777159e-01 0.556 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.935515e-01 0.532 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.400409e-01 0.357 0 0
Dual Incision in GG-NER R-HSA-5696400 3.373261e-01 0.472 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 4.128711e-01 0.384 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.708701e-01 0.327 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.779679e-01 0.556 0 0
DNA methylation R-HSA-5334118 4.123772e-01 0.385 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.123772e-01 0.385 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.614412e-01 0.336 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.534045e-01 0.344 0 0
Signaling by KIT in disease R-HSA-9669938 4.850693e-01 0.314 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.850693e-01 0.314 0 0
Regulation of RAS by GAPs R-HSA-5658442 4.563329e-01 0.341 0 0
G-protein beta:gamma signalling R-HSA-397795 3.011677e-01 0.521 0 0
G0 and Early G1 R-HSA-1538133 2.833167e-01 0.548 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.642626e-01 0.333 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.746972e-01 0.426 0 0
Activation of the pre-replicative complex R-HSA-68962 4.329929e-01 0.364 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.707280e-01 0.431 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.581934e-01 0.446 0 0
Nucleotide Excision Repair R-HSA-5696398 4.111949e-01 0.386 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 3.422330e-01 0.466 0 0
G-protein activation R-HSA-202040 4.373547e-01 0.359 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 4.430697e-01 0.354 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.114710e-01 0.291 0 0
GAB1 signalosome R-HSA-180292 3.630021e-01 0.440 0 0
Regulation of CDH11 function R-HSA-9762292 3.422330e-01 0.466 0 0
PI3K/AKT activation R-HSA-198203 3.422330e-01 0.466 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 3.756006e-01 0.425 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.191859e-01 0.496 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.128711e-01 0.384 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 3.920493e-01 0.407 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.850693e-01 0.314 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 4.463965e-01 0.350 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.735683e-01 0.325 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 2.803202e-01 0.552 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.373261e-01 0.472 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.123772e-01 0.385 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.807176e-01 0.318 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.622301e-01 0.581 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.125099e-01 0.505 0 0
Budding and maturation of HIV virion R-HSA-162588 2.656791e-01 0.576 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 4.373547e-01 0.359 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.081864e-01 0.294 0 0
Orc1 removal from chromatin R-HSA-68949 4.883629e-01 0.311 0 0
Neurexins and neuroligins R-HSA-6794361 3.296552e-01 0.482 0 0
Myogenesis R-HSA-525793 3.498016e-01 0.456 0 0
Repression of WNT target genes R-HSA-4641265 4.400409e-01 0.357 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.769171e-01 0.558 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.965481e-01 0.402 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.620872e-01 0.582 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.724164e-01 0.326 0 0
Signaling by ERBB2 R-HSA-1227986 3.047987e-01 0.516 0 0
Signaling by WNT in cancer R-HSA-4791275 2.833167e-01 0.548 0 0
Calcineurin activates NFAT R-HSA-2025928 3.083177e-01 0.511 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.797774e-01 0.319 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 4.797774e-01 0.319 0 0
Activation of AKT2 R-HSA-165158 4.797774e-01 0.319 0 0
PTK6 Down-Regulation R-HSA-8849472 4.797774e-01 0.319 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.011677e-01 0.521 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 3.880604e-01 0.411 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.373547e-01 0.359 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.006555e-01 0.300 0 0
Amino acids regulate mTORC1 R-HSA-9639288 5.041511e-01 0.297 0 0
MTOR signalling R-HSA-165159 3.257122e-01 0.487 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.129986e-01 0.290 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.555934e-01 0.449 0 0
Signaling by WNT R-HSA-195721 2.931773e-01 0.533 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.152604e-01 0.382 0 0
MyD88-independent TLR4 cascade R-HSA-166166 4.670124e-01 0.331 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.102563e-01 0.387 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.111949e-01 0.386 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.011677e-01 0.521 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 4.670124e-01 0.331 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.534045e-01 0.344 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.129986e-01 0.290 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 2.668490e-01 0.574 0 0
Chylomicron assembly R-HSA-8963888 3.756006e-01 0.425 0 0
Activation of C3 and C5 R-HSA-174577 4.797774e-01 0.319 0 0
Processing of SMDT1 R-HSA-8949664 4.708701e-01 0.327 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.006555e-01 0.300 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.430697e-01 0.354 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.558849e-01 0.341 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.340055e-01 0.476 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.656791e-01 0.576 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.081864e-01 0.294 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.934449e-01 0.307 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 3.257122e-01 0.487 0 0
TBC/RABGAPs R-HSA-8854214 5.166880e-01 0.287 0 0
Circadian clock R-HSA-9909396 5.160989e-01 0.287 0 0
Interferon alpha/beta signaling R-HSA-909733 3.223292e-01 0.492 0 0
DNA Repair R-HSA-73894 4.201550e-01 0.377 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.028057e-01 0.519 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.082874e-01 0.294 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.074931e-01 0.390 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 3.457603e-01 0.461 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.116053e-01 0.506 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.116053e-01 0.506 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.116053e-01 0.506 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 3.729667e-01 0.428 0 0
MET interacts with TNS proteins R-HSA-8875513 3.729667e-01 0.428 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.729667e-01 0.428 0 0
Unwinding of DNA R-HSA-176974 3.083177e-01 0.511 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.288619e-01 0.368 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.422330e-01 0.466 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.422330e-01 0.466 0 0
Ionotropic activity of kainate receptors R-HSA-451306 3.756006e-01 0.425 0 0
NF-kB is activated and signals survival R-HSA-209560 4.082488e-01 0.389 0 0
Synaptic adhesion-like molecules R-HSA-8849932 3.630021e-01 0.440 0 0
Metalloprotease DUBs R-HSA-5689901 3.498016e-01 0.456 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.400409e-01 0.357 0 0
Degradation of CDH1 R-HSA-9766229 2.857865e-01 0.544 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.373261e-01 0.472 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.707280e-01 0.431 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.916050e-01 0.407 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.737992e-01 0.427 0 0
DARPP-32 events R-HSA-180024 4.123772e-01 0.385 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 4.074931e-01 0.390 0 0
Notch-HLH transcription pathway R-HSA-350054 4.850693e-01 0.314 0 0
Ub-specific processing proteases R-HSA-5689880 3.414884e-01 0.467 0 0
Adipogenesis R-HSA-9843745 3.998292e-01 0.398 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.430697e-01 0.354 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.931589e-01 0.307 0 0
HCMV Late Events R-HSA-9610379 2.851296e-01 0.545 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.668490e-01 0.574 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.242834e-01 0.372 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 3.498016e-01 0.456 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.880604e-01 0.411 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.166880e-01 0.287 0 0
Pentose phosphate pathway R-HSA-71336 4.283836e-01 0.368 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 3.083177e-01 0.511 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.128711e-01 0.384 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.829054e-01 0.548 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.283836e-01 0.368 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 4.789379e-01 0.320 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.779679e-01 0.556 0 0
Co-stimulation by CD28 R-HSA-389356 2.714774e-01 0.566 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.994354e-01 0.302 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.288619e-01 0.368 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.797774e-01 0.319 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.102563e-01 0.387 0 0
Platelet homeostasis R-HSA-418346 4.223771e-01 0.374 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 3.288856e-01 0.483 0 0
NGF-stimulated transcription R-HSA-9031628 4.238467e-01 0.373 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.400409e-01 0.357 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.935723e-01 0.307 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 2.854158e-01 0.545 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 4.652310e-01 0.332 0 0
Developmental Biology R-HSA-1266738 5.019007e-01 0.299 1 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.872849e-01 0.542 0 0
Adaptive Immune System R-HSA-1280218 4.565225e-01 0.341 0 0
tRNA Aminoacylation R-HSA-379724 3.047987e-01 0.516 0 0
DNA Damage Bypass R-HSA-73893 2.857865e-01 0.544 0 0
Ion transport by P-type ATPases R-HSA-936837 5.080785e-01 0.294 0 0
Co-inhibition by PD-1 R-HSA-389948 3.936082e-01 0.405 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.911007e-01 0.408 0 0
Intracellular oxygen transport R-HSA-8981607 3.729667e-01 0.428 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.729667e-01 0.428 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.083177e-01 0.511 0 0
NADE modulates death signalling R-HSA-205025 4.288619e-01 0.368 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.872849e-01 0.542 0 0
Inositol transporters R-HSA-429593 4.797774e-01 0.319 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.400409e-01 0.357 0 0
Physiological factors R-HSA-5578768 5.006555e-01 0.300 0 0
Generic Transcription Pathway R-HSA-212436 4.717722e-01 0.326 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.642626e-01 0.333 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.011677e-01 0.521 0 0
PI Metabolism R-HSA-1483255 2.623757e-01 0.581 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.819516e-01 0.317 0 0
TNF signaling R-HSA-75893 3.894394e-01 0.410 0 0
Formation of definitive endoderm R-HSA-9823730 4.128711e-01 0.384 0 0
Sensory processing of sound R-HSA-9659379 4.242834e-01 0.372 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.128711e-01 0.384 0 0
Interleukin-6 signaling R-HSA-1059683 4.708701e-01 0.327 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.320074e-01 0.479 0 0
Gluconeogenesis R-HSA-70263 4.238467e-01 0.373 0 0
Interleukin-1 family signaling R-HSA-446652 4.207959e-01 0.376 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.668490e-01 0.574 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.555446e-01 0.449 0 0
The NLRP3 inflammasome R-HSA-844456 3.880604e-01 0.411 0 0
Cellular hexose transport R-HSA-189200 4.850693e-01 0.314 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 4.493522e-01 0.347 0 0
Signaling by NTRKs R-HSA-166520 4.826270e-01 0.316 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.098164e-01 0.387 0 0
Signaling by NOTCH R-HSA-157118 4.678737e-01 0.330 0 0
Diseases of DNA repair R-HSA-9675135 3.911007e-01 0.408 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.422330e-01 0.466 0 0
Co-inhibition by BTLA R-HSA-9927353 4.797774e-01 0.319 0 0
NrCAM interactions R-HSA-447038 4.797774e-01 0.319 0 0
Sodium/Calcium exchangers R-HSA-425561 4.082488e-01 0.389 0 0
Activation of RAC1 R-HSA-428540 4.082488e-01 0.389 0 0
Negative regulation of MET activity R-HSA-6807004 4.128711e-01 0.384 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 4.708701e-01 0.327 0 0
Ribavirin ADME R-HSA-9755088 4.614412e-01 0.336 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.283836e-01 0.368 0 0
TCR signaling R-HSA-202403 4.670124e-01 0.331 0 0
Heme signaling R-HSA-9707616 4.789379e-01 0.320 0 0
Triglyceride catabolism R-HSA-163560 3.737992e-01 0.427 0 0
p75NTR signals via NF-kB R-HSA-193639 2.622301e-01 0.581 0 0
Heme degradation R-HSA-189483 5.129986e-01 0.290 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.400409e-01 0.357 0 0
Maturation of nucleoprotein R-HSA-9683610 4.708701e-01 0.327 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 4.373547e-01 0.359 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.735683e-01 0.325 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 2.765463e-01 0.558 0 0
Maturation of nucleoprotein R-HSA-9694631 3.880604e-01 0.411 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.650155e-01 0.577 0 0
Inositol phosphate metabolism R-HSA-1483249 2.738174e-01 0.563 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.850693e-01 0.314 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.116053e-01 0.506 0 0
Interleukin-1 processing R-HSA-448706 3.083177e-01 0.511 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.083177e-01 0.511 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.083177e-01 0.511 0 0
Syndecan interactions R-HSA-3000170 5.081864e-01 0.294 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.622301e-01 0.581 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 4.934449e-01 0.307 0 0
Signaling by TGFBR3 R-HSA-9839373 3.911007e-01 0.408 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.873409e-01 0.542 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.708701e-01 0.327 0 0
Zinc transporters R-HSA-435354 5.006555e-01 0.300 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 4.797774e-01 0.319 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.083177e-01 0.511 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.083177e-01 0.511 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.797774e-01 0.319 0 0
Signaling by ALK R-HSA-201556 4.283836e-01 0.368 0 0
Interleukin-7 signaling R-HSA-1266695 3.288856e-01 0.483 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.373547e-01 0.359 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 2.620872e-01 0.582 0 0
Signaling by Leptin R-HSA-2586552 3.422330e-01 0.466 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 4.797774e-01 0.319 0 0
UCH proteinases R-HSA-5689603 5.248433e-01 0.280 0 0
Plus-strand DNA synthesis R-HSA-164525 5.261567e-01 0.279 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.261567e-01 0.279 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.261567e-01 0.279 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.261567e-01 0.279 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.261567e-01 0.279 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.261567e-01 0.279 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.261567e-01 0.279 0 0
Pentose phosphate pathway disease R-HSA-6791465 5.261567e-01 0.279 0 0
PDE3B signalling R-HSA-165160 5.261567e-01 0.279 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.261567e-01 0.279 0 0
Cam-PDE 1 activation R-HSA-111957 5.261567e-01 0.279 0 0
PKB-mediated events R-HSA-109703 5.261567e-01 0.279 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.261567e-01 0.279 0 0
Intestinal hexose absorption R-HSA-8981373 5.261567e-01 0.279 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 5.261567e-01 0.279 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.261567e-01 0.279 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.261567e-01 0.279 0 0
VEGF ligand-receptor interactions R-HSA-194313 5.261567e-01 0.279 0 0
TRAIL signaling R-HSA-75158 5.261567e-01 0.279 0 0
Erythropoietin activates RAS R-HSA-9027284 5.293382e-01 0.276 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.293382e-01 0.276 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.293382e-01 0.276 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.293382e-01 0.276 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 5.293382e-01 0.276 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.293382e-01 0.276 0 0
Biotin transport and metabolism R-HSA-196780 5.293382e-01 0.276 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.307478e-01 0.275 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.307478e-01 0.275 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.307478e-01 0.275 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 5.321974e-01 0.274 0 0
Signal amplification R-HSA-392518 5.321974e-01 0.274 0 0
G alpha (z) signalling events R-HSA-418597 5.351747e-01 0.272 0 0
Paracetamol ADME R-HSA-9753281 5.351747e-01 0.272 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 5.391541e-01 0.268 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 5.503746e-01 0.259 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.504070e-01 0.259 0 0
Regulation of Apoptosis R-HSA-169911 5.510135e-01 0.259 0 0
Signalling to ERKs R-HSA-187687 5.510135e-01 0.259 0 0
PERK regulates gene expression R-HSA-381042 5.510135e-01 0.259 0 0
Oncogene Induced Senescence R-HSA-2559585 5.510135e-01 0.259 0 0
Tight junction interactions R-HSA-420029 5.527161e-01 0.257 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.527161e-01 0.257 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.568782e-01 0.254 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.568782e-01 0.254 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.568782e-01 0.254 0 0
Attachment and Entry R-HSA-9678110 5.568782e-01 0.254 0 0
Regulation of BACH1 activity R-HSA-9708530 5.568782e-01 0.254 0 0
Post-translational protein phosphorylation R-HSA-8957275 5.640936e-01 0.249 0 0
Regulated Necrosis R-HSA-5218859 5.645184e-01 0.248 0 0
Rab regulation of trafficking R-HSA-9007101 5.646766e-01 0.248 0 0
Mitochondrial biogenesis R-HSA-1592230 5.646766e-01 0.248 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.668323e-01 0.247 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.668323e-01 0.247 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.668323e-01 0.247 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.684037e-01 0.245 0 0
Signaling by LTK in cancer R-HSA-9842640 5.684037e-01 0.245 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.684037e-01 0.245 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.684037e-01 0.245 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.684037e-01 0.245 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.684037e-01 0.245 0 0
Uncoating of the HIV Virion R-HSA-162585 5.684037e-01 0.245 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.684037e-01 0.245 0 0
CREB phosphorylation R-HSA-199920 5.684037e-01 0.245 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.684037e-01 0.245 0 0
Lactose synthesis R-HSA-5653890 5.684037e-01 0.245 0 0
Abacavir transmembrane transport R-HSA-2161517 5.684037e-01 0.245 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.684037e-01 0.245 0 0
Metabolism of vitamin K R-HSA-6806664 5.684037e-01 0.245 0 0
HDL clearance R-HSA-8964011 5.684037e-01 0.245 0 0
VLDL assembly R-HSA-8866423 5.684037e-01 0.245 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 5.694220e-01 0.245 0 0
Infectious disease R-HSA-5663205 5.718981e-01 0.243 0 0
Signaling by Nuclear Receptors R-HSA-9006931 5.735161e-01 0.241 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 5.740608e-01 0.241 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.740608e-01 0.241 0 0
Dual incision in TC-NER R-HSA-6782135 5.800719e-01 0.237 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.829444e-01 0.234 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.832512e-01 0.234 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 5.832512e-01 0.234 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.832512e-01 0.234 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.847536e-01 0.233 0 0
Hedgehog 'off' state R-HSA-5610787 5.868343e-01 0.231 0 0
Voltage gated Potassium channels R-HSA-1296072 5.874019e-01 0.231 0 0
Degradation of DVL R-HSA-4641258 5.874019e-01 0.231 0 0
Triglyceride metabolism R-HSA-8979227 5.945420e-01 0.226 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 5.947576e-01 0.226 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.947576e-01 0.226 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 5.947576e-01 0.226 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 5.947576e-01 0.226 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.947576e-01 0.226 0 0
Insulin processing R-HSA-264876 5.947576e-01 0.226 0 0
Maturation of hRSV A proteins R-HSA-9828806 5.947576e-01 0.226 0 0
Interleukin-1 signaling R-HSA-9020702 5.980011e-01 0.223 0 0
Intraflagellar transport R-HSA-5620924 5.987278e-01 0.223 0 0
Metal ion SLC transporters R-HSA-425410 5.987278e-01 0.223 0 0
MET promotes cell motility R-HSA-8875878 6.049352e-01 0.218 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.068863e-01 0.217 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.068863e-01 0.217 0 0
Regulation of PTEN localization R-HSA-8948747 6.068863e-01 0.217 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.068863e-01 0.217 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.068863e-01 0.217 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.068863e-01 0.217 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.068863e-01 0.217 0 0
Disinhibition of SNARE formation R-HSA-114516 6.068863e-01 0.217 0 0
PTK6 Expression R-HSA-8849473 6.068863e-01 0.217 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.068863e-01 0.217 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.068863e-01 0.217 0 0
VLDL clearance R-HSA-8964046 6.068863e-01 0.217 0 0
LDL remodeling R-HSA-8964041 6.068863e-01 0.217 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.068863e-01 0.217 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.068863e-01 0.217 0 0
CHL1 interactions R-HSA-447041 6.068863e-01 0.217 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.068863e-01 0.217 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.068863e-01 0.217 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.084464e-01 0.216 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.084464e-01 0.216 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.084464e-01 0.216 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.084464e-01 0.216 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.084464e-01 0.216 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.084464e-01 0.216 0 0
Specification of primordial germ cells R-HSA-9827857 6.084464e-01 0.216 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.084464e-01 0.216 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.087098e-01 0.216 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.141690e-01 0.212 0 0
Inflammasomes R-HSA-622312 6.147882e-01 0.211 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.152980e-01 0.211 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.178122e-01 0.209 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.220070e-01 0.206 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 6.220070e-01 0.206 0 0
Stabilization of p53 R-HSA-69541 6.220070e-01 0.206 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.226666e-01 0.206 0 0
Azathioprine ADME R-HSA-9748787 6.292565e-01 0.201 0 0
Ca2+ pathway R-HSA-4086398 6.305666e-01 0.200 0 0
Switching of origins to a post-replicative state R-HSA-69052 6.305666e-01 0.200 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.324641e-01 0.199 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.324641e-01 0.199 0 0
Mismatch Repair R-HSA-5358508 6.324641e-01 0.199 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 6.324641e-01 0.199 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.324641e-01 0.199 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 6.341393e-01 0.198 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.341393e-01 0.198 0 0
Immune System R-HSA-168256 6.357010e-01 0.197 0 0
NCAM signaling for neurite out-growth R-HSA-375165 6.363016e-01 0.196 0 0
HIV Transcription Elongation R-HSA-167169 6.386053e-01 0.195 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.386053e-01 0.195 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.386053e-01 0.195 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.386053e-01 0.195 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.386053e-01 0.195 0 0
Diseases of Immune System R-HSA-5260271 6.386053e-01 0.195 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.386053e-01 0.195 0 0
Generation of second messenger molecules R-HSA-202433 6.386053e-01 0.195 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.386053e-01 0.195 0 0
Reverse Transcription of HIV RNA R-HSA-162589 6.419397e-01 0.193 0 0
Minus-strand DNA synthesis R-HSA-164516 6.419397e-01 0.193 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.419397e-01 0.193 0 0
phospho-PLA2 pathway R-HSA-111995 6.419397e-01 0.193 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.419397e-01 0.193 0 0
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 R-HSA-211957 6.419397e-01 0.193 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.419397e-01 0.193 0 0
Interleukin-9 signaling R-HSA-8985947 6.419397e-01 0.193 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.419397e-01 0.193 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.419397e-01 0.193 0 0
Alpha-defensins R-HSA-1462054 6.419397e-01 0.193 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.419397e-01 0.193 0 0
Intestinal absorption R-HSA-8963676 6.419397e-01 0.193 0 0
Interleukin-23 signaling R-HSA-9020933 6.419397e-01 0.193 0 0
Signaling by NOTCH4 R-HSA-9013694 6.430772e-01 0.192 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.439804e-01 0.191 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.480216e-01 0.188 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.495739e-01 0.187 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 6.528025e-01 0.185 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 6.528025e-01 0.185 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.528025e-01 0.185 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.528025e-01 0.185 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 6.528025e-01 0.185 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 6.528025e-01 0.185 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 6.528025e-01 0.185 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 6.547207e-01 0.184 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.547207e-01 0.184 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.547207e-01 0.184 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.553139e-01 0.184 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.553139e-01 0.184 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.553139e-01 0.184 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.553139e-01 0.184 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 6.553139e-01 0.184 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.553139e-01 0.184 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.583327e-01 0.182 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.583327e-01 0.182 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.664651e-01 0.176 0 0
HIV Transcription Initiation R-HSA-167161 6.703464e-01 0.174 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.703464e-01 0.174 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.703464e-01 0.174 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.703464e-01 0.174 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.703464e-01 0.174 0 0
Trafficking of AMPA receptors R-HSA-399719 6.707735e-01 0.173 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 6.707735e-01 0.173 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.723068e-01 0.172 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.723068e-01 0.172 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 6.738694e-01 0.171 0 0
WNT mediated activation of DVL R-HSA-201688 6.738694e-01 0.171 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.738694e-01 0.171 0 0
ALK mutants bind TKIs R-HSA-9700645 6.738694e-01 0.171 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 6.738694e-01 0.171 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.738694e-01 0.171 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.738694e-01 0.171 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.738694e-01 0.171 0 0
Interleukin-21 signaling R-HSA-9020958 6.738694e-01 0.171 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.738694e-01 0.171 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.738694e-01 0.171 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.738694e-01 0.171 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.738694e-01 0.171 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.738694e-01 0.171 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.738694e-01 0.171 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.770132e-01 0.169 0 0
Signaling by NODAL R-HSA-1181150 6.770132e-01 0.169 0 0
Protein hydroxylation R-HSA-9629569 6.770132e-01 0.169 0 0
Regulation of insulin secretion R-HSA-422356 6.871969e-01 0.163 0 0
DNA strand elongation R-HSA-69190 6.880520e-01 0.162 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.880520e-01 0.162 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.880520e-01 0.162 0 0
FOXO-mediated transcription R-HSA-9614085 6.972592e-01 0.157 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.975854e-01 0.156 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.975854e-01 0.156 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.975854e-01 0.156 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.999198e-01 0.155 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.001127e-01 0.155 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.001127e-01 0.155 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.029535e-01 0.153 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.029535e-01 0.153 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.029535e-01 0.153 0 0
Interleukin-27 signaling R-HSA-9020956 7.029535e-01 0.153 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.029535e-01 0.153 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.046409e-01 0.152 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 7.046409e-01 0.152 0 0
ABC-family proteins mediated transport R-HSA-382556 7.071155e-01 0.151 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.119175e-01 0.148 0 0
Signaling by EGFR R-HSA-177929 7.119175e-01 0.148 0 0
Signaling by MET R-HSA-6806834 7.127162e-01 0.147 0 0
Signaling by FGFR2 R-HSA-5654738 7.127162e-01 0.147 0 0
Proteasome assembly R-HSA-9907900 7.142506e-01 0.146 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.142506e-01 0.146 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.170589e-01 0.144 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.170589e-01 0.144 0 0
Attachment and Entry R-HSA-9694614 7.170589e-01 0.144 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 7.170589e-01 0.144 0 0
Mitochondrial calcium ion transport R-HSA-8949215 7.170589e-01 0.144 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 7.170589e-01 0.144 0 0
Glutathione synthesis and recycling R-HSA-174403 7.170589e-01 0.144 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.170589e-01 0.144 0 0
Serine metabolism R-HSA-977347 7.170589e-01 0.144 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.170589e-01 0.144 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 7.205461e-01 0.142 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.205461e-01 0.142 0 0
Vpu mediated degradation of CD4 R-HSA-180534 7.205461e-01 0.142 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.205461e-01 0.142 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.205461e-01 0.142 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.233840e-01 0.141 0 0
DNA Replication R-HSA-69306 7.235642e-01 0.141 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.278927e-01 0.138 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.278927e-01 0.138 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.278927e-01 0.138 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 7.278927e-01 0.138 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.278927e-01 0.138 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.278927e-01 0.138 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 7.278927e-01 0.138 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.294454e-01 0.137 0 0
vRNA Synthesis R-HSA-192814 7.294454e-01 0.137 0 0
vRNP Assembly R-HSA-192905 7.294454e-01 0.137 0 0
Synthesis of PI R-HSA-1483226 7.294454e-01 0.137 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.294454e-01 0.137 0 0
Bicarbonate transporters R-HSA-425381 7.294454e-01 0.137 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 7.294454e-01 0.137 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.294454e-01 0.137 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.294454e-01 0.137 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.294454e-01 0.137 0 0
Transport of RCbl within the body R-HSA-9758890 7.294454e-01 0.137 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.294454e-01 0.137 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 7.337780e-01 0.134 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.354660e-01 0.133 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.354660e-01 0.133 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.354660e-01 0.133 0 0
eNOS activation R-HSA-203615 7.357762e-01 0.133 0 0
Mitophagy R-HSA-5205647 7.357762e-01 0.133 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.357762e-01 0.133 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.357762e-01 0.133 0 0
Signaling by NOTCH2 R-HSA-1980145 7.357762e-01 0.133 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.410421e-01 0.130 0 0
SLC transporter disorders R-HSA-5619102 7.414687e-01 0.130 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 7.451114e-01 0.128 0 0
Regulation of mitotic cell cycle R-HSA-453276 7.451114e-01 0.128 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.456209e-01 0.127 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 7.503420e-01 0.125 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.503420e-01 0.125 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.519020e-01 0.124 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.528420e-01 0.123 0 0
Biosynthesis of maresins R-HSA-9018682 7.528420e-01 0.123 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.528420e-01 0.123 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 7.528420e-01 0.123 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.532457e-01 0.123 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.532457e-01 0.123 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.535761e-01 0.123 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 7.535761e-01 0.123 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.535761e-01 0.123 0 0
Plasmalogen biosynthesis R-HSA-75896 7.535761e-01 0.123 0 0
ERKs are inactivated R-HSA-202670 7.535761e-01 0.123 0 0
FMO oxidises nucleophiles R-HSA-217271 7.535761e-01 0.123 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.535761e-01 0.123 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.535761e-01 0.123 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.537033e-01 0.123 0 0
Toll-like Receptor Cascades R-HSA-168898 7.537662e-01 0.123 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.539959e-01 0.123 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.592880e-01 0.120 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.592880e-01 0.120 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.592880e-01 0.120 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.592880e-01 0.120 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.592880e-01 0.120 0 0
RNA Polymerase III Transcription R-HSA-74158 7.642563e-01 0.117 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.642563e-01 0.117 0 0
FLT3 signaling in disease R-HSA-9682385 7.642563e-01 0.117 0 0
GPER1 signaling R-HSA-9634597 7.658819e-01 0.116 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 7.658819e-01 0.116 0 0
tRNA processing R-HSA-72306 7.689693e-01 0.114 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.692244e-01 0.114 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 7.692244e-01 0.114 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.692244e-01 0.114 0 0
Interleukin-6 family signaling R-HSA-6783589 7.692244e-01 0.114 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.755559e-01 0.110 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 7.755559e-01 0.110 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 7.755559e-01 0.110 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 7.755559e-01 0.110 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.755559e-01 0.110 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.755559e-01 0.110 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.755559e-01 0.110 0 0
Interleukin-35 Signalling R-HSA-8984722 7.755559e-01 0.110 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.755559e-01 0.110 0 0
Signaling by LTK R-HSA-9842663 7.755559e-01 0.110 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.755559e-01 0.110 0 0
Polymerase switching R-HSA-69091 7.755559e-01 0.110 0 0
Leading Strand Synthesis R-HSA-69109 7.755559e-01 0.110 0 0
Synthesis of GDP-mannose R-HSA-446205 7.755559e-01 0.110 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.755559e-01 0.110 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.755559e-01 0.110 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.755559e-01 0.110 0 0
Signaling by FGFR in disease R-HSA-1226099 7.756386e-01 0.110 0 0
Neuronal System R-HSA-112316 7.774332e-01 0.109 0 0
Cleavage of the damaged purine R-HSA-110331 7.775333e-01 0.109 0 0
Degradation of AXIN R-HSA-4641257 7.775333e-01 0.109 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 7.775333e-01 0.109 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.775849e-01 0.109 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.775849e-01 0.109 0 0
Signaling by Hedgehog R-HSA-5358351 7.786609e-01 0.109 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.795081e-01 0.108 0 0
G protein gated Potassium channels R-HSA-1296059 7.846521e-01 0.105 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 7.846521e-01 0.105 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 7.846521e-01 0.105 0 0
Acyl chain remodelling of PS R-HSA-1482801 7.846521e-01 0.105 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.846521e-01 0.105 0 0
Formation of the nephric duct R-HSA-9830364 7.846521e-01 0.105 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.863285e-01 0.104 0 0
Transmission across Chemical Synapses R-HSA-112315 7.872328e-01 0.104 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 7.878417e-01 0.104 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.901887e-01 0.102 0 0
Depurination R-HSA-73927 7.901887e-01 0.102 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.901887e-01 0.102 0 0
Pyruvate metabolism R-HSA-70268 7.903972e-01 0.102 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.907918e-01 0.102 0 0
Signaling by PTK6 R-HSA-8848021 7.907918e-01 0.102 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 7.907918e-01 0.102 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.930005e-01 0.101 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.930005e-01 0.101 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.930005e-01 0.101 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.940710e-01 0.100 0 0
Signaling by NOTCH1 R-HSA-1980143 7.944123e-01 0.100 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 7.955764e-01 0.099 0 0
Formation of axial mesoderm R-HSA-9796292 7.955764e-01 0.099 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 7.955764e-01 0.099 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.955764e-01 0.099 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.959399e-01 0.099 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.959399e-01 0.099 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.959399e-01 0.099 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.991650e-01 0.097 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.991650e-01 0.097 0 0
TRP channels R-HSA-3295583 7.991650e-01 0.097 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.993541e-01 0.097 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 8.005487e-01 0.097 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.022395e-01 0.096 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.099241e-01 0.092 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.099241e-01 0.092 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.099241e-01 0.092 0 0
PCP/CE pathway R-HSA-4086400 8.119549e-01 0.090 0 0
Packaging Of Telomere Ends R-HSA-171306 8.128036e-01 0.090 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.128036e-01 0.090 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.137034e-01 0.090 0 0
Removal of the Flap Intermediate R-HSA-69166 8.138122e-01 0.089 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.138122e-01 0.089 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.138122e-01 0.089 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.138122e-01 0.089 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.138122e-01 0.089 0 0
Hydrolysis of LPC R-HSA-1483115 8.138122e-01 0.089 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.138122e-01 0.089 0 0
Biosynthesis of protectins R-HSA-9018681 8.138122e-01 0.089 0 0
Malate-aspartate shuttle R-HSA-9856872 8.138122e-01 0.089 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.138122e-01 0.089 0 0
Ciprofloxacin ADME R-HSA-9793528 8.138122e-01 0.089 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.138122e-01 0.089 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 8.141294e-01 0.089 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 8.141294e-01 0.089 0 0
Downstream TCR signaling R-HSA-202424 8.150801e-01 0.089 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.198125e-01 0.086 0 0
Nucleotide biosynthesis R-HSA-8956320 8.198125e-01 0.086 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.227881e-01 0.085 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.229685e-01 0.085 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.245987e-01 0.084 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.245987e-01 0.084 0 0
FLT3 Signaling R-HSA-9607240 8.245987e-01 0.084 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.245987e-01 0.084 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.256083e-01 0.083 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.256083e-01 0.083 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.256083e-01 0.083 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.256083e-01 0.083 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.256083e-01 0.083 0 0
Pyroptosis R-HSA-5620971 8.256083e-01 0.083 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 8.292728e-01 0.081 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.304222e-01 0.081 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.304222e-01 0.081 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.304222e-01 0.081 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.304222e-01 0.081 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.304222e-01 0.081 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.304222e-01 0.081 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.304222e-01 0.081 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.304222e-01 0.081 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 8.304222e-01 0.081 0 0
Signaling by Activin R-HSA-1502540 8.304222e-01 0.081 0 0
DCC mediated attractive signaling R-HSA-418885 8.304222e-01 0.081 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.349445e-01 0.078 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.349445e-01 0.078 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.349445e-01 0.078 0 0
Signaling by Erythropoietin R-HSA-9006335 8.376193e-01 0.077 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.376193e-01 0.077 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.376193e-01 0.077 0 0
Glucagon-type ligand receptors R-HSA-420092 8.376193e-01 0.077 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.383163e-01 0.077 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.434202e-01 0.074 0 0
Activation of GABAB receptors R-HSA-991365 8.447600e-01 0.073 0 0
GABA B receptor activation R-HSA-977444 8.447600e-01 0.073 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.447600e-01 0.073 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 8.448832e-01 0.073 0 0
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 8.455513e-01 0.073 0 0
Phosphorylation of the APC/C R-HSA-176412 8.455513e-01 0.073 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.455513e-01 0.073 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.455513e-01 0.073 0 0
Killing mechanisms R-HSA-9664420 8.455513e-01 0.073 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.455513e-01 0.073 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 8.455513e-01 0.073 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.455513e-01 0.073 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.455513e-01 0.073 0 0
Activation of SMO R-HSA-5635838 8.455513e-01 0.073 0 0
Fructose catabolism R-HSA-70350 8.455513e-01 0.073 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.455513e-01 0.073 0 0
Differentiation of T cells R-HSA-9945266 8.455513e-01 0.073 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.455513e-01 0.073 0 0
Negative regulation of FLT3 R-HSA-9706369 8.455513e-01 0.073 0 0
Virus Assembly and Release R-HSA-168268 8.455513e-01 0.073 0 0
RSV-host interactions R-HSA-9833110 8.462342e-01 0.073 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.469547e-01 0.072 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.488762e-01 0.071 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.488762e-01 0.071 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.506692e-01 0.070 0 0
Metabolism of porphyrins R-HSA-189445 8.590864e-01 0.066 0 0
Hedgehog 'on' state R-HSA-5632684 8.590864e-01 0.066 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 8.593314e-01 0.066 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.593314e-01 0.066 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.593314e-01 0.066 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.593314e-01 0.066 0 0
Heme assimilation R-HSA-9927020 8.593314e-01 0.066 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.593314e-01 0.066 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.593314e-01 0.066 0 0
Passive transport by Aquaporins R-HSA-432047 8.593314e-01 0.066 0 0
Synthesis of PG R-HSA-1483148 8.593314e-01 0.066 0 0
Coenzyme A biosynthesis R-HSA-196783 8.593314e-01 0.066 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.593314e-01 0.066 0 0
EGFR downregulation R-HSA-182971 8.594181e-01 0.066 0 0
Downstream signal transduction R-HSA-186763 8.594181e-01 0.066 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.630643e-01 0.064 0 0
Synthesis of DNA R-HSA-69239 8.645330e-01 0.063 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 8.659102e-01 0.063 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.692827e-01 0.061 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.692827e-01 0.061 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.705599e-01 0.060 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 8.712208e-01 0.060 0 0
Nucleosome assembly R-HSA-774815 8.712208e-01 0.060 0 0
Somitogenesis R-HSA-9824272 8.712208e-01 0.060 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.718828e-01 0.060 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.718828e-01 0.060 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.718828e-01 0.060 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.718828e-01 0.060 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.718828e-01 0.060 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.718828e-01 0.060 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.718828e-01 0.060 0 0
Protein localization R-HSA-9609507 8.723664e-01 0.059 0 0
Cardiac conduction R-HSA-5576891 8.778210e-01 0.057 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.785071e-01 0.056 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.791109e-01 0.056 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.791109e-01 0.056 0 0
Regulation of pyruvate metabolism R-HSA-9861718 8.791109e-01 0.056 0 0
Metabolism of proteins R-HSA-392499 8.807173e-01 0.055 0 0
Signaling by FGFR R-HSA-190236 8.812677e-01 0.055 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 8.833150e-01 0.054 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.833150e-01 0.054 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.833150e-01 0.054 0 0
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 8.833150e-01 0.054 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.833150e-01 0.054 0 0
PKA activation in glucagon signalling R-HSA-164378 8.833150e-01 0.054 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 8.833150e-01 0.054 0 0
Apoptotic factor-mediated response R-HSA-111471 8.833150e-01 0.054 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.843170e-01 0.053 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.844948e-01 0.053 0 0
MAP kinase activation R-HSA-450294 8.844948e-01 0.053 0 0
Aquaporin-mediated transport R-HSA-445717 8.844948e-01 0.053 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.844948e-01 0.053 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.871268e-01 0.052 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 8.871268e-01 0.052 0 0
Mitochondrial protein import R-HSA-1268020 8.909588e-01 0.050 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 8.909588e-01 0.050 0 0
ER-Phagosome pathway R-HSA-1236974 8.936669e-01 0.049 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.937277e-01 0.049 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 8.937277e-01 0.049 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.937277e-01 0.049 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.937277e-01 0.049 0 0
Pyrimidine biosynthesis R-HSA-500753 8.937277e-01 0.049 0 0
Translesion Synthesis by POLH R-HSA-110320 8.937277e-01 0.049 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.937277e-01 0.049 0 0
Regulation of signaling by CBL R-HSA-912631 8.937277e-01 0.049 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.951764e-01 0.048 0 0
NOD1/2 Signaling Pathway R-HSA-168638 8.951764e-01 0.048 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.951764e-01 0.048 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.951764e-01 0.048 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.951764e-01 0.048 0 0
Formation of the cornified envelope R-HSA-6809371 8.956514e-01 0.048 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.971183e-01 0.047 0 0
Translation of Structural Proteins R-HSA-9694635 8.971183e-01 0.047 0 0
Base Excision Repair R-HSA-73884 8.988545e-01 0.046 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.002596e-01 0.046 0 0
Integrin cell surface interactions R-HSA-216083 9.025083e-01 0.045 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.026889e-01 0.044 0 0
IGF1R signaling cascade R-HSA-2428924 9.029417e-01 0.044 0 0
Insulin receptor signalling cascade R-HSA-74751 9.029417e-01 0.044 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.032117e-01 0.044 0 0
Creatine metabolism R-HSA-71288 9.032117e-01 0.044 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.032117e-01 0.044 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.032117e-01 0.044 0 0
PI3K Cascade R-HSA-109704 9.065306e-01 0.043 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.072926e-01 0.042 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.084847e-01 0.042 0 0
Cellular response to hypoxia R-HSA-1234174 9.084847e-01 0.042 0 0
GPVI-mediated activation cascade R-HSA-114604 9.096960e-01 0.041 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 9.118499e-01 0.040 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.118499e-01 0.040 0 0
Lagging Strand Synthesis R-HSA-69186 9.118499e-01 0.040 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.118499e-01 0.040 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.118499e-01 0.040 0 0
ERK/MAPK targets R-HSA-198753 9.118499e-01 0.040 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.118499e-01 0.040 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.118499e-01 0.040 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.118499e-01 0.040 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.118499e-01 0.040 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.124424e-01 0.040 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.131335e-01 0.039 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.137447e-01 0.039 0 0
Metabolism of folate and pterines R-HSA-196757 9.162280e-01 0.038 0 0
Amyloid fiber formation R-HSA-977225 9.172277e-01 0.038 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.197176e-01 0.036 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.197176e-01 0.036 0 0
Mitochondrial protein degradation R-HSA-9837999 9.216501e-01 0.035 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.268835e-01 0.033 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.268835e-01 0.033 0 0
Fructose metabolism R-HSA-5652084 9.268835e-01 0.033 0 0
Ethanol oxidation R-HSA-71384 9.268835e-01 0.033 0 0
LDL clearance R-HSA-8964038 9.268835e-01 0.033 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.279815e-01 0.032 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.279815e-01 0.032 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.281923e-01 0.032 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.299811e-01 0.032 0 0
Interleukin-17 signaling R-HSA-448424 9.321837e-01 0.030 0 0
Potassium Channels R-HSA-1296071 9.330526e-01 0.030 0 0
Interleukin-2 family signaling R-HSA-451927 9.332566e-01 0.030 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.334101e-01 0.030 0 0
Interleukin-20 family signaling R-HSA-8854691 9.334101e-01 0.030 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.334101e-01 0.030 0 0
Formation of the ureteric bud R-HSA-9830674 9.334101e-01 0.030 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.334101e-01 0.030 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.334101e-01 0.030 0 0
Carnitine shuttle R-HSA-200425 9.334101e-01 0.030 0 0
Neddylation R-HSA-8951664 9.378390e-01 0.028 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.381643e-01 0.028 0 0
Maturation of spike protein R-HSA-9694548 9.381643e-01 0.028 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.393546e-01 0.027 0 0
CYP2E1 reactions R-HSA-211999 9.393546e-01 0.027 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.393546e-01 0.027 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.393546e-01 0.027 0 0
Complex III assembly R-HSA-9865881 9.393546e-01 0.027 0 0
Interferon gamma signaling R-HSA-877300 9.397036e-01 0.027 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.399959e-01 0.027 0 0
IRS-mediated signalling R-HSA-112399 9.412998e-01 0.026 0 0
Intra-Golgi traffic R-HSA-6811438 9.427280e-01 0.026 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.427280e-01 0.026 0 0
Heme biosynthesis R-HSA-189451 9.427280e-01 0.026 0 0
Translation of Structural Proteins R-HSA-9683701 9.427280e-01 0.026 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.447687e-01 0.025 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.447687e-01 0.025 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 9.447687e-01 0.025 0 0
Laminin interactions R-HSA-3000157 9.447687e-01 0.025 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.451513e-01 0.024 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.456155e-01 0.024 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.469702e-01 0.024 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.469702e-01 0.024 0 0
Depyrimidination R-HSA-73928 9.469702e-01 0.024 0 0
Peroxisomal protein import R-HSA-9033241 9.487667e-01 0.023 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.496997e-01 0.022 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.496997e-01 0.022 0 0
Sphingolipid catabolism R-HSA-9845614 9.496997e-01 0.022 0 0
Abacavir ADME R-HSA-2161522 9.496997e-01 0.022 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.496997e-01 0.022 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.509117e-01 0.022 0 0
GABA receptor activation R-HSA-977443 9.521591e-01 0.021 0 0
Glutathione conjugation R-HSA-156590 9.521591e-01 0.021 0 0
Metabolism of polyamines R-HSA-351202 9.521591e-01 0.021 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.541908e-01 0.020 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.541908e-01 0.020 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.541908e-01 0.020 0 0
Triglyceride biosynthesis R-HSA-75109 9.541908e-01 0.020 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.541908e-01 0.020 0 0
Synthesis of PE R-HSA-1483213 9.541908e-01 0.020 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.541908e-01 0.020 0 0
G1 Phase R-HSA-69236 9.545724e-01 0.020 0 0
Cyclin D associated events in G1 R-HSA-69231 9.545724e-01 0.020 0 0
Netrin-1 signaling R-HSA-373752 9.545724e-01 0.020 0 0
Disease R-HSA-1643685 9.549410e-01 0.020 1 0
Fanconi Anemia Pathway R-HSA-6783310 9.579711e-01 0.019 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.580610e-01 0.019 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 9.582811e-01 0.019 0 0
Insulin receptor recycling R-HSA-77387 9.582811e-01 0.019 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.582811e-01 0.019 0 0
Pyrimidine salvage R-HSA-73614 9.582811e-01 0.019 0 0
Signaling by PDGF R-HSA-186797 9.583234e-01 0.018 0 0
ABC transporter disorders R-HSA-5619084 9.587626e-01 0.018 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.599052e-01 0.018 0 0
Peptide hormone metabolism R-HSA-2980736 9.602212e-01 0.018 0 0
Signaling by Insulin receptor R-HSA-74752 9.606895e-01 0.017 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.611253e-01 0.017 0 0
Thyroxine biosynthesis R-HSA-209968 9.620064e-01 0.017 0 0
mRNA Capping R-HSA-72086 9.620064e-01 0.017 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.620064e-01 0.017 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.620064e-01 0.017 0 0
Collagen formation R-HSA-1474290 9.651061e-01 0.015 0 0
Neurotransmitter clearance R-HSA-112311 9.653993e-01 0.015 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.657123e-01 0.015 0 0
Stimuli-sensing channels R-HSA-2672351 9.671975e-01 0.014 0 0
Chromosome Maintenance R-HSA-73886 9.678825e-01 0.014 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.684893e-01 0.014 0 0
Cargo concentration in the ER R-HSA-5694530 9.684893e-01 0.014 0 0
Extracellular matrix organization R-HSA-1474244 9.706061e-01 0.013 0 0
Post-translational protein modification R-HSA-597592 9.721092e-01 0.012 0 0
Ion channel transport R-HSA-983712 9.722771e-01 0.012 0 0
Telomere Maintenance R-HSA-157579 9.725982e-01 0.012 0 0
Gastrulation R-HSA-9758941 9.730989e-01 0.012 0 0
The phototransduction cascade R-HSA-2514856 9.737742e-01 0.012 0 0
Cardiogenesis R-HSA-9733709 9.738667e-01 0.012 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 9.738667e-01 0.012 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.754043e-01 0.011 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.755600e-01 0.011 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.755600e-01 0.011 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.755600e-01 0.011 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.762010e-01 0.010 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.762686e-01 0.010 0 0
Metabolism of cofactors R-HSA-8978934 9.779077e-01 0.010 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.783269e-01 0.010 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.783269e-01 0.010 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.783269e-01 0.010 0 0
RA biosynthesis pathway R-HSA-5365859 9.783269e-01 0.010 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.783269e-01 0.010 0 0
Hyaluronan metabolism R-HSA-2142845 9.783269e-01 0.010 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.802630e-01 0.009 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.802630e-01 0.009 0 0
RUNX2 regulates bone development R-HSA-8941326 9.820263e-01 0.008 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.820263e-01 0.008 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.820263e-01 0.008 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.820263e-01 0.008 0 0
Neurotransmitter release cycle R-HSA-112310 9.823463e-01 0.008 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.823463e-01 0.008 0 0
Iron uptake and transport R-HSA-917937 9.834473e-01 0.007 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.836321e-01 0.007 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.836321e-01 0.007 0 0
Collagen chain trimerization R-HSA-8948216 9.836321e-01 0.007 0 0
Elastic fibre formation R-HSA-1566948 9.850946e-01 0.007 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.850946e-01 0.007 0 0
Purine salvage R-HSA-74217 9.850946e-01 0.007 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.850946e-01 0.007 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.851791e-01 0.006 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.855736e-01 0.006 0 0
Regulation of beta-cell development R-HSA-186712 9.861783e-01 0.006 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.861783e-01 0.006 0 0
RAS processing R-HSA-9648002 9.864264e-01 0.006 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.874047e-01 0.006 0 0
Glycogen metabolism R-HSA-8982491 9.876393e-01 0.005 0 0
Tryptophan catabolism R-HSA-71240 9.876393e-01 0.005 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 9.876393e-01 0.005 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.879385e-01 0.005 0 0
Collagen degradation R-HSA-1442490 9.882446e-01 0.005 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.897499e-01 0.004 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.897499e-01 0.004 0 0
Innate Immune System R-HSA-168249 9.903750e-01 0.004 0 0
Xenobiotics R-HSA-211981 9.907909e-01 0.004 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.908049e-01 0.004 0 0
Phospholipid metabolism R-HSA-1483257 9.909352e-01 0.004 0 0
PPARA activates gene expression R-HSA-1989781 9.911164e-01 0.004 0 0
Defensins R-HSA-1461973 9.915003e-01 0.004 0 0
Signaling by FGFR4 R-HSA-5654743 9.915003e-01 0.004 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.916404e-01 0.004 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.916612e-01 0.004 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.920738e-01 0.003 0 0
Surfactant metabolism R-HSA-5683826 9.922600e-01 0.003 0 0
Methylation R-HSA-156581 9.922600e-01 0.003 0 0
Amine ligand-binding receptors R-HSA-375280 9.922600e-01 0.003 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.922600e-01 0.003 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.922600e-01 0.003 0 0
Kidney development R-HSA-9830369 9.927954e-01 0.003 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.927954e-01 0.003 0 0
Signaling by FGFR3 R-HSA-5654741 9.929519e-01 0.003 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.931359e-01 0.003 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.931792e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.933634e-01 0.003 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.941558e-01 0.003 0 0
Synthesis of PC R-HSA-1483191 9.941558e-01 0.003 0 0
COPII-mediated vesicle transport R-HSA-204005 9.943709e-01 0.002 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.946783e-01 0.002 0 0
Leishmania infection R-HSA-9658195 9.951339e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.951339e-01 0.002 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.951541e-01 0.002 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.955874e-01 0.002 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.955874e-01 0.002 0 0
Signaling by ERBB4 R-HSA-1236394 9.959566e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.960857e-01 0.002 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.962784e-01 0.002 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.964214e-01 0.002 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.965678e-01 0.001 0 0
Leishmania phagocytosis R-HSA-9664417 9.965678e-01 0.001 0 0
Parasite infection R-HSA-9664407 9.965678e-01 0.001 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.968871e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.974849e-01 0.001 0 0
Signaling by FGFR1 R-HSA-5654736 9.974849e-01 0.001 0 0
Synthesis of PA R-HSA-1483166 9.977099e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.977099e-01 0.001 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.977443e-01 0.001 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.977443e-01 0.001 0 0
Extension of Telomeres R-HSA-180786 9.981013e-01 0.001 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.982464e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.982712e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.982712e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.984259e-01 0.001 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.984775e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.986950e-01 0.001 0 0
Digestion and absorption R-HSA-8963743 9.986950e-01 0.001 0 0
Drug ADME R-HSA-9748784 9.987600e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.988118e-01 0.001 0 0
Keratinization R-HSA-6805567 9.990196e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.991031e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.991031e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.991834e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.993837e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.993837e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.993837e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.993837e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.994644e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.994711e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.994891e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.994891e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.994908e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.995121e-01 0.000 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.995349e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.996271e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.996714e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.996756e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.996756e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.997090e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.997090e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.997944e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.998140e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.998517e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.998758e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.998861e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999018e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999463e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999562e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999566e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999615e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999740e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999756e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999770e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999785e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999809e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999914e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999932e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999944e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999944e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999949e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999955e-01 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 9.999955e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999972e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999978e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999980e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999985e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999990e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999991e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999992e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999995e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999995e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999995e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999998e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999998e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999998e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999999e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999999e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways