DYRK1B

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Y Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Log-Odds: Y Sites / Y Background

Sites with acceptor types representing >8% and count ≥10 are included

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Motif clusters with count ≥ 10 are shown

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substrate_uniprot	site	source	substrate_genes	site_seq
O60841	S186	Sugiyama	EIF5B IF2 KIAA0741	EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O75533	T434	GPS6\|ELM\|iPTMNet\|EPSD\|PSP	SF3B1 SAP155	VLPPPAGYVPIRtPARKLtAtPtPLGGMtGFHMQTEDRTMK
O95817	S173	Sugiyama	BAG3 BIS	QVAAAAAAQPPAsHGPERsQsPAAsDCsssSsSAsLPssGR
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P07814	T737	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	EKTKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRV
P08195	S607	Sugiyama	SLC3A2 MDU1	ASLPAKADLLLstQPGREEGsPLELERLKLEPHEGLLLRFP
P11142	T37	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P13807	S641	SIGNOR	GYS1 GYS	FTYEPNEADAAQGyRyPRPAsVPPsPsLsRHssPHQsEDEE
P15559	S82	Sugiyama	NQO1 DIA4 NMOR1	DPANFQYPAESVLAYKEGHLsPDIVAEQKKLEAADLVIFQF
P18754	S11	Sugiyama	RCC1 CHC1	__________MsPKRIAKRRsPPADAIPKsKKVKVsHRsHs
P20823	S249	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	HNF1A TCF1	RETLVEECNRAECIQRGVsPsQAQGLGSNLVTEVRVYNWFA
P22626	S189	Sugiyama	HNRNPA2B1 HNRPA2B1	IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P24385	T288	SIGNOR\|EPSD\|PSP	CCND1 BCL1 PRAD1	PKAAEEEEEEEEEVDLACtPtDVRDVDI_____________
P27348	S45	Sugiyama	YWHAQ	CMKAVtEQGAELsNEERNLLsVAyKNVVGGRRSAWRVIsSI
P28066	S16	Sugiyama	PSMA5	_____MFLTRsEyDRGVNtFsPEGRLFQVEyAIEAIKLGST
P31946	S47	Sugiyama	YWHAB	AMKAVtEQGHELsNEERNLLsVAyKNVVGARRSsWRVIsSI
P31947	S45	Sugiyama	SFN HME1	FMKGAVEKGEELsCEERNLLsVAyKNVVGGQRAAWRVLSsI
P34931	T39	Sugiyama	HSPA1L	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837	S13	Sugiyama	TALDO1 TAL TALDO TALDOR	________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646	T86	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38936	S153	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1	GPGDSQGRKRRQtsMTDFYHsKRRLIFSKRKP_________
P39019	Y48	Sugiyama	RPS19	LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019	Y54	Sugiyama	RPS19	VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P42166	S159	Sugiyama	TMPO LAP2	RKLYEKKLLKLREQGtEsRsstPLPtIsssAENtRQNGsND
P42167	S159	Sugiyama	TMPO LAP2	RKLYEKKLLKLREQGTESRsstPLPTISsSAENTRQNGSND
P46527	S10	SIGNOR	CDKN1B KIP1 p27	___________MSNVRVSNGsPsLERMDARQAEHPKPSACR
P47712	S724	Sugiyama	PLA2G4A CPLA2 PLA2G4	NIDVIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFL
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P51991	Y360	Sugiyama	HNRNPA3 HNRPA3	QSNYGPMKGGsFGGRssGsPyGGGyGsGGGsGGyGsRRF__
P54652	T38	Sugiyama	HSPA2	CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P55884	S117	Sugiyama	EIF3B EIF3S9	AEPPVPAQGEAPGEQARDERsDsRAQAVsEDAGGNEGRAAE
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	S46	Sugiyama	YWHAG	AMKNVtELNEPLsNEERNLLsVAyKNVVGARRSsWRVIsSI
P62258	S46	Sugiyama	YWHAE	SMKKVAGMDVELTVEERNLLsVAyKNVIGARRASWRIIssI
P62263	T107	Sugiyama	RPS14 PRO2640	ELGITALHIKLRATGGNRtKtPGPGAQsALRALARSGMKIG
P62263	T133	Sugiyama	RPS14 PRO2640	QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62917	S14	Sugiyama	RPL8	_______MGRVIRGQRKGAGsVFRAHVKHRKGAARLRAVDF
P63104	S45	Sugiyama	YWHAZ	CMKsVtEQGAELsNEERNLLsVAyKNVVGARRssWRVVssI
P68363	Y432	Sugiyama	TUBA1B	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P83731	S38	Sugiyama	RPL24	GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P84243	T46	EPSD	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	ARKsAPsTGGVKKPHRyRPGtVALREIRRYQKstELLIRKL
Q02363	T27	EPSD\|PSP	ID2 BHLHB26	VRSVRKNsLSDHSLGISRsKtPVDDPMSLLYNMNDCYSKLK
Q04917	S46	Sugiyama	YWHAH YWHA1	AMKAVtELNEPLsNEDRNLLsVAyKNVVGARRSsWRVIsSI
Q07960	S51	Sugiyama	ARHGAP1 CDC42GAP RHOGAP1	KNWPsDEMPDFPKsDDsKsssPELVtHLKWDDPyyDIARHQ
Q13247	S301	Sugiyama	SRSF6 SFRS6 SRP55	PKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKR
Q13247	S303	Sugiyama	SRSF6 SFRS6 SRP55	ENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKRAT
Q13283	S232	Sugiyama	G3BP1 G3BP	EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13627	S97	Sugiyama	DYRK1A DYRK MNB MNBH	LQRRMPQtFRDPAtAPLRKLsVDLIKTYKHINEVyYAKKKR
Q13627	Y111	Sugiyama	DYRK1A DYRK MNB MNBH	APLRKLsVDLIKTYKHINEVyYAKKKRRHQQGQGDDSSHKK
Q13627	Y321	Sugiyama	DYRK1A DYRK MNB MNBH	SAIKIVDFGSSCQLGQRIyQyIQSRFYRSPEVLLGMPYDLA
Q14160	S1486	Sugiyama	SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL	RHQERLRVQsPEPPAPERALsPAELRALEAEKRALWRAARM
Q14258	S100	Sugiyama	TRIM25 EFP RNF147 ZNF147	DLAREPPADVWtPPARAsAPsPNAQVACDHCLKEAAVKTCL
Q52LA3	S28	PSP	LIN52 C14orf46	PTDGTDLEASLLSFEKLDRAsPDLWPEQLPGVAEFAAsFKs
Q71U36	Y432	Sugiyama	TUBA1A TUBA3	GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q86W56	Y832	Sugiyama	PARG	DDWQRRCTEIVAIDALHFRRyLDQFVPEKMRRELNKAYCGF
Q8IZ21	S118	Sugiyama	PHACTR4 PRO2963	PSDAMLKNGHTTPIGNARsssPVQVEEEPVRLAsLRKAIPE
Q8TC07	S675	Sugiyama	TBC1D15	TSAFQSNALPTLSASGARNDsPtQIPVssDVCRLtPA____
Q8WWM7	S111	Sugiyama	ATXN2L A2D A2LG A2LP A2RP	PGAAAIGsARGQstGKGPPQsPVFEGVyNNSRMLHFLTAVV
Q96KQ7	T555	PSP	EHMT2 BAT8 C6orf30 G9A KMT1C NG36	HCGEDASEAQEVTIPRGDGVtPPAGtAAPAPPPLsQDVPGR
Q99801	S185	PSP	NKX3-1 NKX3.1 NKX3A	EtQVKIWFQNRRYKTKRKQLssELGDLEKHssLPALKEEAF
Q99801	S186	PSP	NKX3-1 NKX3.1 NKX3A	tQVKIWFQNRRYKTKRKQLssELGDLEKHssLPALKEEAFS
Q9C0C2	S1103	Sugiyama	TNKS1BP1 KIAA1741 TAB182	KRGWVGEFSLSVGPQREAAFsPGQQDWsRDFCIEASERsyQ
Q9C0C2	S672	Sugiyama	TNKS1BP1 KIAA1741 TAB182	TLARAETtQARtEAQDLCRAsPEPPGPEsSSRWLDDLLAsP
Q9HCN4	S301	Sugiyama	GPN1 MBDIN RPAP4 XAB1 HUSSY-23	ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD
Q9NTJ3	T48	Sugiyama	SMC4 CAPC SMC4L1	sDAEPEPPsGRtEsPAtAAEtAsEELDNRSLEEILNSIPPP
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UKV0	S240	SIGNOR	HDAC9 HDAC7 HDAC7B HDRP KIAA0744 MITR	sEPNLKVRSRLKQKVAERRssPLLRRKDGNVVTsFKKRMFE
Q9UQ35	S1103	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35	S295	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRSRSRSAAAKtHttALAGRsPsPAsGRRGEGDAPFsEPGt
Q9UQ35	S297	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	SRSRSAAAKtHttALAGRsPsPAsGRRGEGDAPFsEPGtts
Q9UQL6	S279	SIGNOR	HDAC5 KIAA0600	sEPNLKVRSRLKQKVAERRssPLLRRKDGTVIStFKKRAVE
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y463	S421	EPSD\|PSP	DYRK1B MIRK	YLRFQDLVLRMLEYEPAARIsPLGALQHGFFRRTADEATNT
Q9Y463	S49	Sugiyama	DYRK1B MIRK	LPRRLPLAFRDATSAPLRKLsVDLIKTYKHINEVyYAKKKR
Q9Y463	Y271	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	DYRK1B MIRK	KRSAIKIVDFGSSCQLGQRIyQyIQSRFYRSPEVLLGTPYD
Q9Y463	Y273	SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP\|Sugiyama	DYRK1B MIRK	SAIKIVDFGSSCQLGQRIyQyIQSRFYRSPEVLLGTPYDLA
Q9Y463	Y63	Sugiyama	DYRK1B MIRK	APLRKLsVDLIKTYKHINEVyYAKKKRRAQQAPPQDSSNKK

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p
Regulation of TP53 Activity	R-HSA-5633007	1.150854e-08	7.939
Cell Cycle	R-HSA-1640170	2.120785e-08	7.674
Chromatin organization	R-HSA-4839726	4.916161e-08	7.308
Chromatin modifying enzymes	R-HSA-3247509	2.466254e-07	6.608
Cell Cycle, Mitotic	R-HSA-69278	1.042059e-06	5.982
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.921519e-06	5.716
PKMTs methylate histone lysines	R-HSA-3214841	2.660243e-06	5.575
Transcriptional Regulation by TP53	R-HSA-3700989	1.557193e-05	4.808
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	2.094643e-05	4.679
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.159950e-05	4.500
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	5.872153e-05	4.231
Nuclear Envelope Breakdown	R-HSA-2980766	7.371842e-05	4.132
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	1.586723e-04	3.799
NRAGE signals death through JNK	R-HSA-193648	1.606615e-04	3.794
Signaling by NTRKs	R-HSA-166520	2.439296e-04	3.613
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.655255e-04	3.576
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	3.012443e-04	3.521
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	3.012443e-04	3.521
Circadian clock	R-HSA-9909396	4.085093e-04	3.389
Gene expression (Transcription)	R-HSA-74160	3.963850e-04	3.402
Signaling by NTRK1 (TRKA)	R-HSA-187037	4.371525e-04	3.359
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	5.982203e-04	3.223
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	7.370636e-04	3.132
AKT phosphorylates targets in the nucleus	R-HSA-198693	1.174666e-03	2.930
Mitotic Prophase	R-HSA-68875	1.104370e-03	2.957
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.159075e-03	2.936
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.279855e-03	2.893
Cell Cycle Checkpoints	R-HSA-69620	1.287416e-03	2.890
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	1.350572e-03	2.869
M Phase	R-HSA-68886	1.839079e-03	2.735
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.091663e-03	2.680
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	2.309578e-03	2.636
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.280315e-03	2.642
Cardiogenesis	R-HSA-9733709	2.309578e-03	2.636
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.309578e-03	2.636
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	2.133074e-03	2.671
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.149454e-03	2.668
G1/S-Specific Transcription	R-HSA-69205	1.982585e-03	2.703
RNA Polymerase II Transcription	R-HSA-73857	2.410888e-03	2.618
Deubiquitination	R-HSA-5688426	2.615418e-03	2.582
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.856264e-03	2.544
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	2.924044e-03	2.534
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	3.593402e-03	2.444
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	3.593402e-03	2.444
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	3.435765e-03	2.464
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	3.333166e-03	2.477
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.585639e-03	2.445
Epigenetic regulation of gene expression	R-HSA-212165	3.575790e-03	2.447
G2/M DNA damage checkpoint	R-HSA-69473	3.356599e-03	2.474
NGF-stimulated transcription	R-HSA-9031628	3.553625e-03	2.449
Polo-like kinase mediated events	R-HSA-156711	3.781121e-03	2.422
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.781121e-03	2.422
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	4.124338e-03	2.385
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	4.124338e-03	2.385
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	4.266580e-03	2.370
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	4.279290e-03	2.369
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.310476e-03	2.365
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	5.435494e-03	2.265
AKT phosphorylates targets in the cytosol	R-HSA-198323	5.655081e-03	2.248
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.655081e-03	2.248
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.413776e-03	2.266
Impaired BRCA2 binding to PALB2	R-HSA-9709603	4.953113e-03	2.305
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	6.389014e-03	2.195
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	6.389014e-03	2.195
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	6.389014e-03	2.195
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	6.389014e-03	2.195
IPs transport between nucleus and cytosol	R-HSA-1855170	6.156214e-03	2.211
Transport of the SLBP independent Mature mRNA	R-HSA-159227	6.156214e-03	2.211
Vpr-mediated nuclear import of PICs	R-HSA-180910	6.191228e-03	2.208
RUNX2 regulates bone development	R-HSA-8941326	5.157342e-03	2.288
G2/M Transition	R-HSA-69275	5.909208e-03	2.228
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.156214e-03	2.211
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	5.413776e-03	2.266
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	5.655081e-03	2.248
G alpha (12/13) signalling events	R-HSA-416482	5.657733e-03	2.247
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	6.367278e-03	2.196
MITF-M-dependent gene expression	R-HSA-9856651	5.786855e-03	2.238
Mitotic G2-G2/M phases	R-HSA-453274	6.889287e-03	2.162
Mitotic G1 phase and G1/S transition	R-HSA-453279	6.912962e-03	2.160
Impaired BRCA2 binding to RAD51	R-HSA-9709570	7.324419e-03	2.135
Signal Transduction	R-HSA-162582	6.942798e-03	2.158
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	7.466223e-03	2.127
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	7.466223e-03	2.127
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	7.466223e-03	2.127
Transcriptional activation of p53 responsive genes	R-HSA-69560	8.422067e-03	2.075
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	8.422067e-03	2.075
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	8.422067e-03	2.075
AKT-mediated inactivation of FOXO1A	R-HSA-211163	8.422067e-03	2.075
GRB7 events in ERBB2 signaling	R-HSA-1306955	8.422067e-03	2.075
ATP-dependent chromatin remodelers	R-HSA-9932444	8.673080e-03	2.062
SWI/SNF chromatin remodelers	R-HSA-9932451	8.673080e-03	2.062
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	8.673080e-03	2.062
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	8.750582e-03	2.058
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	8.419612e-03	2.075
DNA Double-Strand Break Repair	R-HSA-5693532	7.463065e-03	2.127
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.908665e-03	2.050
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.908665e-03	2.050
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	7.432909e-03	2.129
NS1 Mediated Effects on Host Pathways	R-HSA-168276	8.750582e-03	2.058
Nuclear import of Rev protein	R-HSA-180746	8.908665e-03	2.050
mRNA Splicing	R-HSA-72172	9.524451e-03	2.021
Regulation of PTEN gene transcription	R-HSA-8943724	9.628016e-03	2.016
AURKA Activation by TPX2	R-HSA-8854518	1.021069e-02	1.991
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.030852e-02	1.987
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	1.078965e-02	1.967
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	1.109303e-02	1.955
MITF-M-regulated melanocyte development	R-HSA-9730414	1.140849e-02	1.943
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.141039e-02	1.943
Generic Transcription Pathway	R-HSA-212436	1.196286e-02	1.922
p75 NTR receptor-mediated signalling	R-HSA-193704	1.196638e-02	1.922
G1/S Transition	R-HSA-69206	1.196911e-02	1.922
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.207432e-02	1.918
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.355468e-02	1.868
Notch-HLH transcription pathway	R-HSA-350054	1.264564e-02	1.898
Death Receptor Signaling	R-HSA-73887	1.322013e-02	1.879
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.284552e-02	1.891
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.409783e-02	1.851
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.409783e-02	1.851
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	1.410325e-02	1.851
Signaling by MRAS-complex mutants	R-HSA-9660537	1.565159e-02	1.805
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	1.565159e-02	1.805
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.501643e-02	1.823
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.501643e-02	1.823
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.521690e-02	1.818
Processing of DNA double-strand break ends	R-HSA-5693607	1.543561e-02	1.811
Specification of the neural plate border	R-HSA-9834899	1.492487e-02	1.826
Mitotic Prometaphase	R-HSA-68877	1.542201e-02	1.812
Gastrulation	R-HSA-9758941	1.452368e-02	1.838
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	1.608710e-02	1.794
mRNA Splicing - Major Pathway	R-HSA-72163	1.648269e-02	1.783
Homology Directed Repair	R-HSA-5693538	1.714330e-02	1.766
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	1.719960e-02	1.764
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	1.719960e-02	1.764
Transcriptional regulation by RUNX1	R-HSA-8878171	1.733067e-02	1.761
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.758243e-02	1.755
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.852481e-02	1.732
Signaling by ERBB2	R-HSA-1227986	1.942499e-02	1.712
Resolution of D-Loop Structures	R-HSA-5693537	1.798525e-02	1.745
Signaling by LTK	R-HSA-9842663	1.987585e-02	1.702
Transcriptional Regulation by E2F6	R-HSA-8953750	1.997017e-02	1.700
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.006629e-02	1.698
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.050145e-02	1.688
Estrogen-dependent gene expression	R-HSA-9018519	2.082323e-02	1.681
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	2.175840e-02	1.662
Phosphorylation of Emi1	R-HSA-176417	2.175840e-02	1.662
RAF activation	R-HSA-5673000	2.106499e-02	1.676
RNA Polymerase II Transcription Termination	R-HSA-73856	2.183644e-02	1.661
DNA Double Strand Break Response	R-HSA-5693606	2.240356e-02	1.650
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.196802e-02	1.658
HATs acetylate histones	R-HSA-3214847	2.104645e-02	1.677
Interactions of Rev with host cellular proteins	R-HSA-177243	2.305982e-02	1.637
Oncogenic MAPK signaling	R-HSA-6802957	2.318182e-02	1.635
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	2.320800e-02	1.634
G2/M Checkpoints	R-HSA-69481	2.335049e-02	1.632
Transcriptional regulation of granulopoiesis	R-HSA-9616222	2.446797e-02	1.611
Heme signaling	R-HSA-9707616	2.446797e-02	1.611
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	2.451576e-02	1.611
DNA Repair	R-HSA-73894	2.615655e-02	1.582
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.865551e-02	1.543
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.865551e-02	1.543
MET interacts with TNS proteins	R-HSA-8875513	2.858033e-02	1.544
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	2.858033e-02	1.544
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	2.858033e-02	1.544
MET activates RAP1 and RAC1	R-HSA-8875555	2.931145e-02	1.533
RET signaling	R-HSA-8853659	2.835983e-02	1.547
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	2.883291e-02	1.540
Specification of primordial germ cells	R-HSA-9827857	2.729812e-02	1.564
Diseases of DNA repair	R-HSA-9675135	2.799275e-02	1.553
Diseases of mitotic cell cycle	R-HSA-9675126	3.016169e-02	1.521
Mitotic Anaphase	R-HSA-68882	3.042440e-02	1.517
Transcriptional regulation by RUNX2	R-HSA-8878166	3.057436e-02	1.515
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.153611e-02	1.501
Mitotic Metaphase and Anaphase	R-HSA-2555396	3.218188e-02	1.492
Regulation of KIT signaling	R-HSA-1433559	3.257454e-02	1.487
Ovarian tumor domain proteases	R-HSA-5689896	3.261838e-02	1.487
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	3.268259e-02	1.486
Adipogenesis	R-HSA-9843745	3.382494e-02	1.471
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	3.496546e-02	1.456
Nuclear RNA decay	R-HSA-9930044	3.496546e-02	1.456
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	3.829185e-02	1.417
Formation of the posterior neural plate	R-HSA-9832991	3.829185e-02	1.417
DNA Damage Recognition in GG-NER	R-HSA-5696394	4.027752e-02	1.395
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	4.119611e-02	1.385
Mitotic Spindle Checkpoint	R-HSA-69618	3.866230e-02	1.413
Germ layer formation at gastrulation	R-HSA-9754189	4.044795e-02	1.393
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.829185e-02	1.417
Formation of the anterior neural plate	R-HSA-9823739	4.053425e-02	1.392
DCC mediated attractive signaling	R-HSA-418885	4.053425e-02	1.392
Cohesin Loading onto Chromatin	R-HSA-2470946	4.351564e-02	1.361
Cyclin D associated events in G1	R-HSA-69231	4.393875e-02	1.357
G1 Phase	R-HSA-69236	4.393875e-02	1.357
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	4.414213e-02	1.355
Amplification of signal from the kinetochores	R-HSA-141424	4.414213e-02	1.355
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	4.473002e-02	1.349
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.495470e-02	1.347
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	4.495470e-02	1.347
PI3K/AKT Signaling in Cancer	R-HSA-2219528	4.522838e-02	1.345
Activation of RAC1	R-HSA-428540	4.878227e-02	1.312
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	4.989760e-02	1.302
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	4.989760e-02	1.302
Centrosome maturation	R-HSA-380287	4.944924e-02	1.306
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.899577e-02	1.310
Formation of definitive endoderm	R-HSA-9823730	4.834247e-02	1.316
Prolonged ERK activation events	R-HSA-169893	4.962507e-02	1.304
TGFBR3 expression	R-HSA-9839394	5.366153e-02	1.270
Signalling to ERKs	R-HSA-187687	5.250374e-02	1.280
S Phase	R-HSA-69242	5.062094e-02	1.296
Downregulation of ERBB2 signaling	R-HSA-8863795	4.989760e-02	1.302
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.997314e-02	1.301
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	4.931557e-02	1.307
Interleukin-37 signaling	R-HSA-9008059	4.989760e-02	1.302
ISG15 antiviral mechanism	R-HSA-1169408	4.944924e-02	1.306
FLT3 Signaling	R-HSA-9607240	5.416817e-02	1.266
PIP3 activates AKT signaling	R-HSA-1257604	5.464513e-02	1.262
Cyclin E associated events during G1/S transition	R-HSA-69202	5.471269e-02	1.262
Apoptotic execution phase	R-HSA-75153	5.512496e-02	1.259
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	5.512496e-02	1.259
mRNA 3'-end processing	R-HSA-72187	5.554553e-02	1.255
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	5.771175e-02	1.239
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	5.987205e-02	1.223
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	6.059343e-02	1.218
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	6.080549e-02	1.216
Repression of WNT target genes	R-HSA-4641265	6.080549e-02	1.216
PTEN Regulation	R-HSA-6807070	6.110942e-02	1.214
snRNP Assembly	R-HSA-191859	6.118151e-02	1.213
Metabolism of non-coding RNA	R-HSA-194441	6.118151e-02	1.213
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	6.502647e-02	1.187
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	6.502647e-02	1.187
G0 and Early G1	R-HSA-1538133	6.515517e-02	1.186
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.515517e-02	1.186
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	7.435778e-02	1.129
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	7.435778e-02	1.129
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	7.435778e-02	1.129
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	7.435778e-02	1.129
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	7.128554e-02	1.147
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.757413e-02	1.110
Frs2-mediated activation	R-HSA-170968	7.435778e-02	1.129
Intracellular signaling by second messengers	R-HSA-9006925	6.879820e-02	1.162
RNA Polymerase II Pre-transcription Events	R-HSA-674695	7.688708e-02	1.114
MTOR signalling	R-HSA-165159	6.785990e-02	1.168
Signaling by TGFB family members	R-HSA-9006936	6.928836e-02	1.159
Late Phase of HIV Life Cycle	R-HSA-162599	7.724939e-02	1.112
HDR through Homologous Recombination (HRR)	R-HSA-5685942	7.229401e-02	1.141
Viral Messenger RNA Synthesis	R-HSA-168325	7.354956e-02	1.133
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	7.757413e-02	1.110
tRNA processing in the nucleus	R-HSA-6784531	8.030434e-02	1.095
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.119921e-02	1.090
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	8.173552e-02	1.088
Regulation of TP53 Expression and Degradation	R-HSA-6806003	8.374829e-02	1.077
FOXO-mediated transcription of cell death genes	R-HSA-9614657	8.386147e-02	1.076
Regulation of TP53 Activity through Methylation	R-HSA-6804760	8.386147e-02	1.076
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	8.421153e-02	1.075
Cellular response to heat stress	R-HSA-3371556	8.421153e-02	1.075
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	9.689528e-02	1.014
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	9.689528e-02	1.014
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	9.689528e-02	1.014
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	9.689528e-02	1.014
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	9.689528e-02	1.014
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	9.689528e-02	1.014
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	9.689528e-02	1.014
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	9.689528e-02	1.014
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	9.689528e-02	1.014
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	9.689528e-02	1.014
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	9.689528e-02	1.014
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	8.848250e-02	1.053
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	8.848250e-02	1.053
Regulation of CDH19 Expression and Function	R-HSA-9764302	8.848250e-02	1.053
Negative feedback regulation of MAPK pathway	R-HSA-5674499	8.848250e-02	1.053
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	8.848250e-02	1.053
MAPK3 (ERK1) activation	R-HSA-110056	9.253487e-02	1.034
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	9.253487e-02	1.034
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	8.941057e-02	1.049
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	8.941057e-02	1.049
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	1.017309e-01	0.993
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.034605e-01	0.985
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.301832e-02	1.031
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.301832e-02	1.031
mRNA Splicing - Minor Pathway	R-HSA-72165	1.014243e-01	0.994
Formation of RNA Pol II elongation complex	R-HSA-112382	9.953361e-02	1.002
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	9.097349e-02	1.041
FOXO-mediated transcription	R-HSA-9614085	9.106264e-02	1.041
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	1.034605e-01	0.985
Signal attenuation	R-HSA-74749	9.253487e-02	1.034
Regulation of TP53 Expression	R-HSA-6804754	9.689528e-02	1.014
VEGFA-VEGFR2 Pathway	R-HSA-4420097	8.728640e-02	1.059
Regulation of CDH1 Gene Transcription	R-HSA-9764560	9.247786e-02	1.034
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	9.253487e-02	1.034
Glycolysis	R-HSA-70171	9.718175e-02	1.012
Erythropoietin activates RAS	R-HSA-9027284	1.059128e-01	0.975
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.085644e-01	0.964
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	1.111967e-01	0.954
Transcriptional Regulation by MECP2	R-HSA-8986944	1.114650e-01	0.953
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	1.129391e-01	0.947
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	1.144449e-01	0.941
ESR-mediated signaling	R-HSA-8939211	1.146297e-01	0.941
Kinesins	R-HSA-983189	1.146606e-01	0.941
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.149288e-01	0.940
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	1.149288e-01	0.940
G2/M DNA replication checkpoint	R-HSA-69478	1.149288e-01	0.940
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	1.149288e-01	0.940
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.223230e-01	0.912
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	1.223230e-01	0.912
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.223230e-01	0.912
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	1.394084e-01	0.856
MET activates PTPN11	R-HSA-8865999	1.394084e-01	0.856
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	1.439273e-01	0.842
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	1.439273e-01	0.842
RUNX3 regulates WNT signaling	R-HSA-8951430	1.439273e-01	0.842
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	1.439273e-01	0.842
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.439273e-01	0.842
Regulation of PTEN localization	R-HSA-8948747	1.439273e-01	0.842
SOS-mediated signalling	R-HSA-112412	1.439273e-01	0.842
Disinhibition of SNARE formation	R-HSA-114516	1.439273e-01	0.842
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.351318e-01	0.869
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	1.351318e-01	0.869
Signaling by AXIN mutants	R-HSA-4839735	1.351318e-01	0.869
Differentiation of T cells	R-HSA-9945266	1.237937e-01	0.907
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	1.237937e-01	0.907
Phosphorylation of the APC/C	R-HSA-176412	1.237937e-01	0.907
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.237937e-01	0.907
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.429654e-01	0.845
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.429654e-01	0.845
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.283212e-01	0.892
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.425190e-01	0.846
Transcriptional regulation by RUNX3	R-HSA-8878159	1.217217e-01	0.915
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.268942e-01	0.897
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	1.394646e-01	0.856
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.429654e-01	0.845
ERK/MAPK targets	R-HSA-198753	1.283212e-01	0.892
Activation of SMO	R-HSA-5635838	1.237937e-01	0.907
RNA Polymerase I Transcription Initiation	R-HSA-73762	1.243192e-01	0.905
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	1.425190e-01	0.846
Regulation of MECP2 expression and activity	R-HSA-9022692	1.425190e-01	0.846
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.394084e-01	0.856
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	1.358897e-01	0.867
HIV Life Cycle	R-HSA-162587	1.187362e-01	0.925
Activation of ATR in response to replication stress	R-HSA-176187	1.425190e-01	0.846
Signaling by NOTCH1	R-HSA-1980143	1.424675e-01	0.846
Activation of PUMA and translocation to mitochondria	R-HSA-139915	1.439273e-01	0.842
Signaling by PTK6	R-HSA-8848021	1.437588e-01	0.842
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.437588e-01	0.842
Disorders of Developmental Biology	R-HSA-9675151	1.429654e-01	0.845
Signaling by SCF-KIT	R-HSA-1433557	1.358897e-01	0.867
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	1.421736e-01	0.847
Signaling by NTRK2 (TRKB)	R-HSA-9006115	1.446697e-01	0.840
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.452437e-01	0.838
Netrin-1 signaling	R-HSA-373752	1.480073e-01	0.830
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.589271e-01	0.799
RUNX3 regulates p14-ARF	R-HSA-8951936	1.589271e-01	0.799
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.589271e-01	0.799
RUNX3 regulates NOTCH signaling	R-HSA-8941856	1.589271e-01	0.799
SHC-related events triggered by IGF1R	R-HSA-2428933	1.589271e-01	0.799
Signaling by VEGF	R-HSA-194138	1.592763e-01	0.798
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	1.606394e-01	0.794
Formation of the Early Elongation Complex	R-HSA-113418	1.606394e-01	0.794
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.296893e-01	0.639
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.296893e-01	0.639
Diseases of Telomere Maintenance	R-HSA-9673013	2.296893e-01	0.639
Drug-mediated inhibition of MET activation	R-HSA-9734091	2.296893e-01	0.639
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	R-HSA-9036092	2.296893e-01	0.639
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	2.296893e-01	0.639
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.296893e-01	0.639
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.296893e-01	0.639
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	2.296893e-01	0.639
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.850371e-01	0.733
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.850371e-01	0.733
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	1.850371e-01	0.733
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	1.850371e-01	0.733
Defective LFNG causes SCDO3	R-HSA-5083630	1.850371e-01	0.733
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.239270e-01	0.490
XAV939 stabilizes AXIN	R-HSA-5545619	3.239270e-01	0.490
TRAF3 deficiency - HSE	R-HSA-5602571	3.239270e-01	0.490
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	3.239270e-01	0.490
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	3.239270e-01	0.490
Signaling by TCF7L2 mutants	R-HSA-5339700	3.239270e-01	0.490
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	3.239270e-01	0.490
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	3.239270e-01	0.490
Defective GFPT1 causes CMSTA1	R-HSA-4085023	3.239270e-01	0.490
Defective VWF binding to collagen type I	R-HSA-9845622	3.239270e-01	0.490
PTEN Loss of Function in Cancer	R-HSA-5674404	3.239270e-01	0.490
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	3.239270e-01	0.490
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	3.239270e-01	0.490
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	2.323838e-01	0.634
SMAC (DIABLO) binds to IAPs	R-HSA-111463	2.323838e-01	0.634
Activation of AKT2	R-HSA-165158	2.323838e-01	0.634
IRS activation	R-HSA-74713	2.323838e-01	0.634
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	2.323838e-01	0.634
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.323838e-01	0.634
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	2.323838e-01	0.634
Type I hemidesmosome assembly	R-HSA-446107	1.750238e-01	0.757
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	1.750238e-01	0.757
MET receptor recycling	R-HSA-8875656	1.750238e-01	0.757
GP1b-IX-V activation signalling	R-HSA-430116	2.077678e-01	0.682
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	2.077678e-01	0.682
Inactivation of CDC42 and RAC1	R-HSA-428543	2.077678e-01	0.682
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	2.803461e-01	0.552
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	2.803461e-01	0.552
Signalling to p38 via RIT and RIN	R-HSA-187706	2.803461e-01	0.552
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	2.803461e-01	0.552
PDE3B signalling	R-HSA-165160	2.803461e-01	0.552
PTK6 Regulates Cell Cycle	R-HSA-8849470	2.803461e-01	0.552
PKB-mediated events	R-HSA-109703	2.803461e-01	0.552
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	2.803461e-01	0.552
Regulation of cortical dendrite branching	R-HSA-8985801	4.066407e-01	0.391
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	4.066407e-01	0.391
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.066407e-01	0.391
Defective VWF cleavage by ADAMTS13 variant	R-HSA-9845621	4.066407e-01	0.391
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	4.066407e-01	0.391
Enhanced cleavage of VWF variant by ADAMTS13	R-HSA-9845619	4.066407e-01	0.391
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	1.841235e-01	0.735
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.841235e-01	0.735
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	3.280654e-01	0.484
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.280654e-01	0.484
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.847628e-01	0.733
ChREBP activates metabolic gene expression	R-HSA-163765	2.764961e-01	0.558
Activated NTRK3 signals through RAS	R-HSA-9034864	2.764961e-01	0.558
Signaling by APC mutants	R-HSA-4839744	2.764961e-01	0.558
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.764961e-01	0.558
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.764961e-01	0.558
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.764961e-01	0.558
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.378745e-01	0.624
E2F mediated regulation of DNA replication	R-HSA-113510	2.071547e-01	0.684
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.071547e-01	0.684
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.071547e-01	0.684
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.773637e-01	0.751
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.014493e-01	0.696
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	3.117051e-01	0.506
Activated NTRK2 signals through RAS	R-HSA-9026519	3.117051e-01	0.506
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	3.117051e-01	0.506
Signaling by GSK3beta mutants	R-HSA-5339716	3.117051e-01	0.506
MET activates PI3K/AKT signaling	R-HSA-8851907	3.748838e-01	0.426
NOSTRIN mediated eNOS trafficking	R-HSA-203641	3.748838e-01	0.426
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.748838e-01	0.426
TRIF-mediated programmed cell death	R-HSA-2562578	3.748838e-01	0.426
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	3.748838e-01	0.426
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	3.748838e-01	0.426
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	3.748838e-01	0.426
Recycling of eIF2:GDP	R-HSA-72731	3.748838e-01	0.426
Activation of BIM and translocation to mitochondria	R-HSA-111446	4.792391e-01	0.319
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.792391e-01	0.319
Defective GSS causes GSS deficiency	R-HSA-5579006	4.792391e-01	0.319
Signaling by ERBB2 in Cancer	R-HSA-1227990	1.947898e-01	0.710
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	2.542949e-01	0.595
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.946908e-01	0.531
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.946908e-01	0.531
Trafficking of AMPA receptors	R-HSA-399719	2.128610e-01	0.672
VEGFR2 mediated vascular permeability	R-HSA-5218920	1.807470e-01	0.743
MET activates RAS signaling	R-HSA-8851805	3.470208e-01	0.460
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	3.470208e-01	0.460
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	3.470208e-01	0.460
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	3.470208e-01	0.460
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	3.470208e-01	0.460
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	3.470208e-01	0.460
Signaling downstream of RAS mutants	R-HSA-9649948	1.738124e-01	0.760
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.738124e-01	0.760
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.738124e-01	0.760
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	2.787833e-01	0.555
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.641494e-01	0.578
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.641494e-01	0.578
PI3K events in ERBB2 signaling	R-HSA-1963642	3.237394e-01	0.490
RSK activation	R-HSA-444257	4.203077e-01	0.376
Regulation by c-FLIP	R-HSA-3371378	4.203077e-01	0.376
Dimerization of procaspase-8	R-HSA-69416	4.203077e-01	0.376
Regulation of NPAS4 mRNA translation	R-HSA-9768778	4.203077e-01	0.376
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	3.037113e-01	0.518
MET promotes cell motility	R-HSA-8875878	2.382821e-01	0.623
HIV elongation arrest and recovery	R-HSA-167287	2.860876e-01	0.544
Pausing and recovery of HIV elongation	R-HSA-167290	2.860876e-01	0.544
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	3.529630e-01	0.452
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	3.289528e-01	0.483
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	3.289528e-01	0.483
Signaling by Erythropoietin	R-HSA-9006335	3.083953e-01	0.511
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.000820e-01	0.699
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	1.747312e-01	0.758
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	2.742359e-01	0.562
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	2.742359e-01	0.562
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	1.849365e-01	0.733
IGF1R signaling cascade	R-HSA-2428924	2.364260e-01	0.626
Condensation of Prophase Chromosomes	R-HSA-2299718	2.766518e-01	0.558
Activation of the pre-replicative complex	R-HSA-68962	3.309833e-01	0.480
Regulation of signaling by CBL	R-HSA-912631	3.821885e-01	0.418
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	4.168332e-01	0.380
ARMS-mediated activation	R-HSA-170984	4.639778e-01	0.334
CASP8 activity is inhibited	R-HSA-5218900	4.639778e-01	0.334
ALK mutants bind TKIs	R-HSA-9700645	4.639778e-01	0.334
TNFR1-mediated ceramide production	R-HSA-5626978	5.429586e-01	0.265
HCN channels	R-HSA-1296061	5.429586e-01	0.265
PLCG1 events in ERBB2 signaling	R-HSA-1251932	5.429586e-01	0.265
Signaling by MAP2K mutants	R-HSA-9652169	5.429586e-01	0.265
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.723633e-01	0.764
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	3.115528e-01	0.506
Signaling by RAF1 mutants	R-HSA-9656223	3.115528e-01	0.506
HIV Transcription Initiation	R-HSA-167161	3.115528e-01	0.506
RNA Polymerase II Transcription Initiation	R-HSA-75953	3.115528e-01	0.506
Downstream signal transduction	R-HSA-186763	3.537644e-01	0.451
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.786826e-01	0.555
Negative regulation of MET activity	R-HSA-6807004	4.112572e-01	0.386
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.112572e-01	0.386
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	3.520852e-01	0.453
Spry regulation of FGF signaling	R-HSA-1295596	4.508563e-01	0.346
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	4.508563e-01	0.346
Beta-catenin phosphorylation cascade	R-HSA-196299	4.508563e-01	0.346
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	4.508563e-01	0.346
ERBB2 Regulates Cell Motility	R-HSA-6785631	4.508563e-01	0.346
RNA Polymerase II Promoter Escape	R-HSA-73776	3.498153e-01	0.456
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	4.053673e-01	0.392
Separation of Sister Chromatids	R-HSA-2467813	2.151394e-01	0.667
Regulation of mitotic cell cycle	R-HSA-453276	3.384615e-01	0.470
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.384615e-01	0.470
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	4.307037e-01	0.366
Nuclear Receptor transcription pathway	R-HSA-383280	3.354395e-01	0.474
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	3.886091e-01	0.410
Regulation of endogenous retroelements	R-HSA-9842860	3.110457e-01	0.507
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	4.840355e-01	0.315
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	4.016947e-01	0.396
MAP2K and MAPK activation	R-HSA-5674135	4.566806e-01	0.340
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	5.162214e-01	0.287
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.162214e-01	0.287
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.162214e-01	0.287
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	5.451412e-01	0.263
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	5.988848e-01	0.223
NOSIP mediated eNOS trafficking	R-HSA-203754	5.988848e-01	0.223
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.988848e-01	0.223
FLT3 signaling by CBL mutants	R-HSA-9706377	5.988848e-01	0.223
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.988848e-01	0.223
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	4.900280e-01	0.310
Interleukin receptor SHC signaling	R-HSA-912526	5.233207e-01	0.281
HSF1-dependent transactivation	R-HSA-3371571	5.043194e-01	0.297
Deadenylation of mRNA	R-HSA-429947	5.497558e-01	0.260
TRAF6 mediated NF-kB activation	R-HSA-933542	5.497558e-01	0.260
ERKs are inactivated	R-HSA-202670	5.823781e-01	0.235
Regulation of PTEN stability and activity	R-HSA-8948751	5.415328e-01	0.266
IRS-related events triggered by IGF1R	R-HSA-2428928	5.449746e-01	0.264
Translation initiation complex formation	R-HSA-72649	5.597232e-01	0.252
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	5.620678e-01	0.250
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	5.951276e-01	0.225
Ribosomal scanning and start codon recognition	R-HSA-72702	5.951276e-01	0.225
Pre-NOTCH Processing in Golgi	R-HSA-1912420	6.057640e-01	0.218
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	6.173159e-01	0.209
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	6.173159e-01	0.209
IRAK1 recruits IKK complex	R-HSA-937039	6.173159e-01	0.209
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.479704e-01	0.188
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	6.479704e-01	0.188
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	6.479704e-01	0.188
IkBA variant leads to EDA-ID	R-HSA-5603029	6.479704e-01	0.188
Noncanonical activation of NOTCH3	R-HSA-9017802	6.479704e-01	0.188
Signaling by RNF43 mutants	R-HSA-5340588	6.479704e-01	0.188
IRS-mediated signalling	R-HSA-112399	6.122922e-01	0.213
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	6.188143e-01	0.208
PI3K Cascade	R-HSA-109704	6.313803e-01	0.200
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	6.330470e-01	0.199
Negative regulation of FGFR3 signaling	R-HSA-5654732	6.470644e-01	0.189
Activation of AMPK downstream of NMDARs	R-HSA-9619483	6.470644e-01	0.189
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	4.315244e-01	0.365
Transcription of the HIV genome	R-HSA-167172	2.934122e-01	0.533
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	4.923025e-01	0.308
Insulin receptor signalling cascade	R-HSA-74751	5.954083e-01	0.225
Degradation of beta-catenin by the destruction complex	R-HSA-195253	4.391294e-01	0.357
EGFR downregulation	R-HSA-182971	5.289053e-01	0.277
Signaling by NOTCH3	R-HSA-9012852	5.775968e-01	0.238
Transcriptional regulation of testis differentiation	R-HSA-9690406	2.946908e-01	0.531
HIV Transcription Elongation	R-HSA-167169	2.742359e-01	0.562
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	5.771649e-01	0.239
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	4.627590e-01	0.335
Listeria monocytogenes entry into host cells	R-HSA-8876384	4.683648e-01	0.329
Signaling by MET	R-HSA-6806834	3.648093e-01	0.438
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	4.627590e-01	0.335
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	4.627590e-01	0.335
Nucleotide Excision Repair	R-HSA-5696398	2.734479e-01	0.563
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	3.821487e-01	0.418
mRNA Capping	R-HSA-72086	4.805940e-01	0.318
VxPx cargo-targeting to cilium	R-HSA-5620916	4.112572e-01	0.386
Switching of origins to a post-replicative state	R-HSA-69052	6.113267e-01	0.214
Neurexins and neuroligins	R-HSA-6794361	1.670648e-01	0.777
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.502690e-01	0.602
Sensing of DNA Double Strand Breaks	R-HSA-5693548	3.117051e-01	0.506
p75NTR recruits signalling complexes	R-HSA-209543	3.470208e-01	0.460
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.764611e-01	0.239
Negative regulation of MAPK pathway	R-HSA-5675221	1.956083e-01	0.709
RNA Polymerase III Transcription	R-HSA-74158	4.900280e-01	0.310
Synaptic adhesion-like molecules	R-HSA-8849932	3.529630e-01	0.452
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	2.742359e-01	0.562
Developmental Lineages of the Mammary Gland	R-HSA-9924644	5.959392e-01	0.225
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	3.237394e-01	0.490
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.309833e-01	0.480
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	6.240916e-01	0.205
Interleukin-6 signaling	R-HSA-1059683	3.821487e-01	0.418
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.185294e-01	0.497
Hedgehog 'on' state	R-HSA-5632684	2.380121e-01	0.623
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	3.821487e-01	0.418
Regulation of the apoptosome activity	R-HSA-9627069	5.056433e-01	0.296
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	4.301582e-01	0.366
Cytochrome c-mediated apoptotic response	R-HSA-111461	5.823781e-01	0.235
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	6.290698e-01	0.201
Interleukin-15 signaling	R-HSA-8983432	3.470208e-01	0.460
Signaling by BMP	R-HSA-201451	2.641494e-01	0.578
Signaling by EGFR	R-HSA-177929	4.563167e-01	0.341
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	6.257459e-01	0.204
Signaling by WNT in cancer	R-HSA-4791275	2.315166e-01	0.635
Hedgehog 'off' state	R-HSA-5610787	5.862122e-01	0.232
Signaling by Activin	R-HSA-1502540	2.378745e-01	0.624
Transcriptional regulation by small RNAs	R-HSA-5578749	1.689790e-01	0.772
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.560628e-01	0.592
Co-inhibition by CTLA4	R-HSA-389513	4.112572e-01	0.386
Formation of apoptosome	R-HSA-111458	5.056433e-01	0.296
PI3K/AKT activation	R-HSA-198203	5.056433e-01	0.296
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	4.878637e-01	0.312
Negative regulation of the PI3K/AKT network	R-HSA-199418	5.234562e-01	0.281
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	6.479704e-01	0.188
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	6.119336e-01	0.213
Protein-protein interactions at synapses	R-HSA-6794362	1.648209e-01	0.783
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	3.110457e-01	0.507
RNA Polymerase I Transcription	R-HSA-73864	5.665533e-01	0.247
Downstream signaling of activated FGFR3	R-HSA-5654708	4.805940e-01	0.318
Downstream signaling of activated FGFR4	R-HSA-5654716	5.049830e-01	0.297
Signaling by FGFR2	R-HSA-5654738	5.966482e-01	0.224
Downstream signaling of activated FGFR2	R-HSA-5654696	6.396362e-01	0.194
Signaling by FGFR4	R-HSA-5654743	3.498153e-01	0.456
Signaling by RAS mutants	R-HSA-6802949	1.738124e-01	0.760
p75NTR signals via NF-kB	R-HSA-193639	4.508563e-01	0.346
RNA Polymerase III Transcription Initiation	R-HSA-76046	5.049830e-01	0.297
TNF signaling	R-HSA-75893	3.275057e-01	0.485
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	2.077678e-01	0.682
Formation of axial mesoderm	R-HSA-9796292	1.841235e-01	0.735
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	1.818818e-01	0.740
Adrenoceptors	R-HSA-390696	4.203077e-01	0.376
mTORC1-mediated signalling	R-HSA-166208	3.037113e-01	0.518
Regulation of gap junction activity	R-HSA-191650	5.429586e-01	0.265
RNA Polymerase I Transcription Termination	R-HSA-73863	4.307037e-01	0.366
Ligand-receptor interactions	R-HSA-5632681	6.479704e-01	0.188
Downstream signaling of activated FGFR1	R-HSA-5654687	6.396362e-01	0.194
Signaling by FGFR3	R-HSA-5654741	3.886091e-01	0.410
Rab regulation of trafficking	R-HSA-9007101	2.705538e-01	0.568
Regulation of TNFR1 signaling	R-HSA-5357905	1.738124e-01	0.760
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.426705e-01	0.615
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	5.485087e-01	0.261
Activation of HOX genes during differentiation	R-HSA-5619507	5.485087e-01	0.261
Cilium Assembly	R-HSA-5617833	3.948198e-01	0.404
Signaling by Hedgehog	R-HSA-5358351	5.499768e-01	0.260
Rap1 signalling	R-HSA-392517	2.071547e-01	0.684
Long-term potentiation	R-HSA-9620244	2.217409e-01	0.654
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	5.802722e-01	0.236
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	6.173159e-01	0.209
Deadenylation-dependent mRNA decay	R-HSA-429914	6.454422e-01	0.190
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	3.537644e-01	0.451
Sema4D in semaphorin signaling	R-HSA-400685	3.798938e-01	0.420
Clathrin-mediated endocytosis	R-HSA-8856828	5.299918e-01	0.276
TCF dependent signaling in response to WNT	R-HSA-201681	2.623158e-01	0.581
Signaling by NOTCH	R-HSA-157118	5.869830e-01	0.231
Post-transcriptional silencing by small RNAs	R-HSA-426496	2.323838e-01	0.634
Calcineurin activates NFAT	R-HSA-2025928	2.077678e-01	0.682
Signaling by NODAL	R-HSA-1181150	4.112572e-01	0.386
EGFR Transactivation by Gastrin	R-HSA-2179392	5.056433e-01	0.296
CD28 dependent PI3K/Akt signaling	R-HSA-389357	4.307037e-01	0.366
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.988848e-01	0.223
Amino acids regulate mTORC1	R-HSA-9639288	5.415328e-01	0.266
Signaling by FGFR1	R-HSA-5654736	5.951276e-01	0.225
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.057640e-01	0.218
Signaling by FGFR1 in disease	R-HSA-5655302	6.155543e-01	0.211
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	5.959392e-01	0.225
Signaling by Nuclear Receptors	R-HSA-9006931	4.049714e-01	0.393
Pre-NOTCH Transcription and Translation	R-HSA-1912408	5.424387e-01	0.266
DAP12 signaling	R-HSA-2424491	3.309833e-01	0.480
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.843408e-01	0.734
Interleukin-2 signaling	R-HSA-9020558	5.451412e-01	0.263
MAPK1/MAPK3 signaling	R-HSA-5684996	2.970494e-01	0.527
Regulation of necroptotic cell death	R-HSA-5675482	5.751112e-01	0.240
Pexophagy	R-HSA-9664873	2.417267e-01	0.617
RAF/MAP kinase cascade	R-HSA-5673001	4.157329e-01	0.381
Signaling by WNT	R-HSA-195721	4.893506e-01	0.310
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	1.631208e-01	0.787
Cell-extracellular matrix interactions	R-HSA-446353	2.378745e-01	0.624
FasL/ CD95L signaling	R-HSA-75157	4.792391e-01	0.319
Inhibition of nitric oxide production	R-HSA-9636249	4.792391e-01	0.319
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	2.426705e-01	0.615
Lipophagy	R-HSA-9613354	4.639778e-01	0.334
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.429586e-01	0.265
Ub-specific processing proteases	R-HSA-5689880	2.386881e-01	0.622
HDACs deacetylate histones	R-HSA-3214815	4.381594e-01	0.358
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	3.289528e-01	0.483
Neurofascin interactions	R-HSA-447043	3.280654e-01	0.484
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.083953e-01	0.511
Vasopressin-like receptors	R-HSA-388479	5.429586e-01	0.265
Myogenesis	R-HSA-525793	4.053673e-01	0.392
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.957142e-01	0.403
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.957142e-01	0.403
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.957142e-01	0.403
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.957142e-01	0.403
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	4.358739e-01	0.361
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	5.823781e-01	0.235
Signaling by Hippo	R-HSA-2028269	1.633260e-01	0.787
MAPK family signaling cascades	R-HSA-5683057	2.927365e-01	0.534
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	2.105105e-01	0.677
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.237394e-01	0.490
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.237394e-01	0.490
UCH proteinases	R-HSA-5689603	2.144997e-01	0.669
CD209 (DC-SIGN) signaling	R-HSA-5621575	5.497558e-01	0.260
Metabolism of RNA	R-HSA-8953854	1.945520e-01	0.711
Organelle biogenesis and maintenance	R-HSA-1852241	5.424677e-01	0.266
Cellular Senescence	R-HSA-2559583	2.373162e-01	0.625
HDMs demethylate histones	R-HSA-3214842	2.217409e-01	0.654
Co-stimulation by CD28	R-HSA-389356	5.952079e-01	0.225
Signaling by EGFR in Cancer	R-HSA-1643713	6.001918e-01	0.222
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.400254e-01	0.357
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.400254e-01	0.357
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	5.620678e-01	0.250
Membrane Trafficking	R-HSA-199991	4.840091e-01	0.315
Formation of editosomes by ADAR proteins	R-HSA-77042	2.296893e-01	0.639
NrCAM interactions	R-HSA-447038	2.323838e-01	0.634
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.323838e-01	0.634
mRNA Editing: A to I Conversion	R-HSA-75064	4.066407e-01	0.391
C6 deamination of adenosine	R-HSA-75102	4.066407e-01	0.391
TGFBR3 regulates activin signaling	R-HSA-9839406	4.066407e-01	0.391
CREB phosphorylation	R-HSA-199920	3.280654e-01	0.484
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	3.280654e-01	0.484
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	1.847628e-01	0.733
Bicarbonate transporters	R-HSA-425381	2.764961e-01	0.558
Signaling by AMER1 mutants	R-HSA-4839748	3.117051e-01	0.506
Activated NTRK2 signals through CDK5	R-HSA-9032845	3.748838e-01	0.426
MET activates STAT3	R-HSA-8875791	4.792391e-01	0.319
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.787833e-01	0.555
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.203077e-01	0.376
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.821487e-01	0.418
Unwinding of DNA	R-HSA-176974	4.639778e-01	0.334
MASTL Facilitates Mitotic Progression	R-HSA-2465910	4.639778e-01	0.334
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	5.429586e-01	0.265
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	5.056433e-01	0.296
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	5.056433e-01	0.296
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	4.840355e-01	0.315
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.988848e-01	0.223
Reelin signalling pathway	R-HSA-8866376	5.988848e-01	0.223
NTRK2 activates RAC1	R-HSA-9032759	5.988848e-01	0.223
Evasion by RSV of host interferon responses	R-HSA-9833109	5.289053e-01	0.277
NF-kB is activated and signals survival	R-HSA-209560	5.823781e-01	0.235
Condensation of Prometaphase Chromosomes	R-HSA-2514853	5.823781e-01	0.235
PKA activation in glucagon signalling	R-HSA-164378	5.771649e-01	0.239
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	5.755757e-01	0.240
TRAIL signaling	R-HSA-75158	6.479704e-01	0.188
Pentose phosphate pathway disease	R-HSA-6791465	6.479704e-01	0.188
CDC6 association with the ORC:origin complex	R-HSA-68689	6.479704e-01	0.188
Synthesis of PS	R-HSA-1483101	6.479704e-01	0.188
Macroautophagy	R-HSA-1632852	5.840402e-01	0.234
Signaling by FGFR4 in disease	R-HSA-5655291	4.168332e-01	0.380
Transcriptional Regulation by VENTX	R-HSA-8853884	1.807470e-01	0.743
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.380121e-01	0.623
RMTs methylate histone arginines	R-HSA-3214858	3.691712e-01	0.433
p53-Dependent G1 DNA Damage Response	R-HSA-69563	4.662190e-01	0.331
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	4.662190e-01	0.331
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.506936e-01	0.601
Effects of PIP2 hydrolysis	R-HSA-114508	5.972957e-01	0.224
TP53 Regulates Metabolic Genes	R-HSA-5628897	4.070490e-01	0.390
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	1.773637e-01	0.751
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.055520e-01	0.392
Post NMDA receptor activation events	R-HSA-438064	3.747724e-01	0.426
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	2.077678e-01	0.682
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.378745e-01	0.624
MDK and PTN in ALK signaling	R-HSA-9851151	5.429586e-01	0.265
Receptor Mediated Mitophagy	R-HSA-8934903	5.056433e-01	0.296
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.563167e-01	0.341
Formation of the ureteric bud	R-HSA-9830674	5.233207e-01	0.281
Negative regulation of FLT3	R-HSA-9706369	4.840355e-01	0.315
RAF-independent MAPK1/3 activation	R-HSA-112409	4.961625e-01	0.304
MAP kinase activation	R-HSA-450294	5.449746e-01	0.264
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.378745e-01	0.624
Formation of intermediate mesoderm	R-HSA-9761174	5.056433e-01	0.296
SARS-CoV-2 modulates autophagy	R-HSA-9754560	5.451412e-01	0.263
Interleukin-17 signaling	R-HSA-448424	5.643436e-01	0.248
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.479704e-01	0.188
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.479704e-01	0.188
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	6.378845e-01	0.195
Programmed Cell Death	R-HSA-5357801	6.248086e-01	0.204
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	3.305920e-01	0.481
Signaling by TGFBR3	R-HSA-9839373	1.738124e-01	0.760
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.596713e-01	0.586
Integrin signaling	R-HSA-354192	2.506936e-01	0.601
HIV Infection	R-HSA-162906	6.103467e-01	0.214
Apoptosis	R-HSA-109581	4.852112e-01	0.314
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	2.555904e-01	0.592
Platelet Aggregation (Plug Formation)	R-HSA-76009	3.886091e-01	0.410
Signal transduction by L1	R-HSA-445144	6.330470e-01	0.199
SARS-CoV-2-host interactions	R-HSA-9705683	2.821299e-01	0.550
Tie2 Signaling	R-HSA-210993	3.529630e-01	0.452
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	3.869695e-01	0.412
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.086785e-01	0.681
Breakdown of the nuclear lamina	R-HSA-352238	3.239270e-01	0.490
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	2.417267e-01	0.617
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.792391e-01	0.319
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	1.720642e-01	0.764
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	4.168332e-01	0.380
MAPK1 (ERK2) activation	R-HSA-112411	4.639778e-01	0.334
Sensory perception of sour taste	R-HSA-9729555	5.429586e-01	0.265
Metalloprotease DUBs	R-HSA-5689901	4.053673e-01	0.392
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	4.840355e-01	0.315
Signaling by PDGFR in disease	R-HSA-9671555	4.683648e-01	0.329
Synthesis of PI	R-HSA-1483226	5.451412e-01	0.263
RHOBTB3 ATPase cycle	R-HSA-9706019	5.451412e-01	0.263
Signaling by ALK in cancer	R-HSA-9700206	3.869695e-01	0.412
Signaling by NTRK3 (TRKC)	R-HSA-9034015	4.683648e-01	0.329
FLT3 signaling in disease	R-HSA-9682385	3.312949e-01	0.480
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.957142e-01	0.403
Nephrin family interactions	R-HSA-373753	6.330470e-01	0.199
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	4.566806e-01	0.340
Calmodulin induced events	R-HSA-111933	4.900280e-01	0.310
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.750238e-01	0.757
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	2.077678e-01	0.682
CaM pathway	R-HSA-111997	4.900280e-01	0.310
Regulation of CDH11 gene transcription	R-HSA-9762293	2.077678e-01	0.682
Signaling by ALK	R-HSA-201556	2.560628e-01	0.592
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	4.168332e-01	0.380
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	5.317807e-01	0.274
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	4.508563e-01	0.346
G-protein beta:gamma signalling	R-HSA-397795	5.751112e-01	0.240
Activation of BH3-only proteins	R-HSA-114452	1.947898e-01	0.710
Ca-dependent events	R-HSA-111996	6.347274e-01	0.197
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.748838e-01	0.426
MECP2 regulates transcription factors	R-HSA-9022707	3.748838e-01	0.426
Sodium/Proton exchangers	R-HSA-425986	4.203077e-01	0.376
Dopamine receptors	R-HSA-390651	5.429586e-01	0.265
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.429586e-01	0.265
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	4.840355e-01	0.315
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.988848e-01	0.223
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	5.233207e-01	0.281
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	4.935973e-01	0.307
Anchoring fibril formation	R-HSA-2214320	5.823781e-01	0.235
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	5.751112e-01	0.240
Relaxin receptors	R-HSA-444821	6.479704e-01	0.188
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	6.240916e-01	0.205
Inositol phosphate metabolism	R-HSA-1483249	1.996533e-01	0.700
Other interleukin signaling	R-HSA-449836	6.057640e-01	0.218
Regulation of TP53 Degradation	R-HSA-6804757	2.040980e-01	0.690
Neurodegenerative Diseases	R-HSA-8863678	3.543857e-01	0.451
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	3.543857e-01	0.451
Gene Silencing by RNA	R-HSA-211000	4.858515e-01	0.313
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	2.542949e-01	0.595
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.961625e-01	0.304
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	4.626845e-01	0.335
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.307037e-01	0.366
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.323838e-01	0.634
Activation of BAD and translocation to mitochondria	R-HSA-111447	4.508563e-01	0.346
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	4.400254e-01	0.357
WNT5A-dependent internalization of FZD4	R-HSA-5099900	4.840355e-01	0.315
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.988848e-01	0.223
Disorders of Nervous System Development	R-HSA-9697154	6.173159e-01	0.209
Pervasive developmental disorders	R-HSA-9005895	6.173159e-01	0.209
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.173159e-01	0.209
Aryl hydrocarbon receptor signalling	R-HSA-8937144	6.479704e-01	0.188
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.529630e-01	0.452
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	6.382969e-01	0.195
Glucose metabolism	R-HSA-70326	2.705538e-01	0.568
Cellular response to mitochondrial stress	R-HSA-9840373	4.639778e-01	0.334
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	6.001918e-01	0.222
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	5.988848e-01	0.223
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	5.951276e-01	0.225
Signaling by Leptin	R-HSA-2586552	5.056433e-01	0.296
Maturation of hRSV A proteins	R-HSA-9828806	6.240916e-01	0.205
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	5.771649e-01	0.239
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	6.499596e-01	0.187
PI5P Regulates TP53 Acetylation	R-HSA-6811555	6.499596e-01	0.187
RNA Polymerase I Promoter Clearance	R-HSA-73854	6.556599e-01	0.183
SHC-mediated cascade:FGFR3	R-HSA-5654704	6.589876e-01	0.181
Signalling to RAS	R-HSA-167044	6.589876e-01	0.181
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	6.589876e-01	0.181
Zygotic genome activation (ZGA)	R-HSA-9819196	6.589876e-01	0.181
GPVI-mediated activation cascade	R-HSA-114604	6.597369e-01	0.181
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	6.624472e-01	0.179
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.637092e-01	0.178
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.637092e-01	0.178
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.637092e-01	0.178
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	6.656496e-01	0.177
Autophagy	R-HSA-9612973	6.690373e-01	0.175
Negative regulation of FGFR4 signaling	R-HSA-5654733	6.690870e-01	0.175
Late endosomal microautophagy	R-HSA-9615710	6.690870e-01	0.175
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	6.690870e-01	0.175
Termination of translesion DNA synthesis	R-HSA-5656169	6.690870e-01	0.175
Regulation of gene expression in beta cells	R-HSA-210745	6.690870e-01	0.175
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.693448e-01	0.174
EPHB-mediated forward signaling	R-HSA-3928662	6.713281e-01	0.173
DAP12 interactions	R-HSA-2172127	6.713281e-01	0.173
SARS-CoV-1-host interactions	R-HSA-9692914	6.743809e-01	0.171
Regulation of PD-L1(CD274) expression	R-HSA-9909648	6.780764e-01	0.169
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.803476e-01	0.167
Retrograde neurotrophin signalling	R-HSA-177504	6.803476e-01	0.167
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	6.820299e-01	0.166
Meiotic synapsis	R-HSA-1221632	6.820299e-01	0.166
SHC-mediated cascade:FGFR4	R-HSA-5654719	6.835759e-01	0.165
Nucleosome assembly	R-HSA-774815	6.887234e-01	0.162
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	6.887234e-01	0.162
DAG and IP3 signaling	R-HSA-1489509	6.887234e-01	0.162
Signaling by LTK in cancer	R-HSA-9842640	6.910518e-01	0.160
Erythropoietin activates STAT5	R-HSA-9027283	6.910518e-01	0.160
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	6.910518e-01	0.160
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.910518e-01	0.160
MET Receptor Activation	R-HSA-6806942	6.910518e-01	0.160
Agmatine biosynthesis	R-HSA-351143	6.910518e-01	0.160
NADPH regeneration	R-HSA-389542	6.910518e-01	0.160
Nef and signal transduction	R-HSA-164944	6.910518e-01	0.160
CREB3 factors activate genes	R-HSA-8874211	6.910518e-01	0.160
Sensory processing of sound	R-HSA-9659379	6.969945e-01	0.157
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.975199e-01	0.156
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.977081e-01	0.156
NoRC negatively regulates rRNA expression	R-HSA-427413	7.013015e-01	0.154
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.055006e-01	0.152
G1/S DNA Damage Checkpoints	R-HSA-69615	7.066047e-01	0.151
FGFR2 alternative splicing	R-HSA-6803529	7.068157e-01	0.151
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.068157e-01	0.151
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.068157e-01	0.151
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	7.085429e-01	0.150
Translesion synthesis by REV1	R-HSA-110312	7.085429e-01	0.150
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	7.085429e-01	0.150
SHC1 events in EGFR signaling	R-HSA-180336	7.085429e-01	0.150
Telomere C-strand synthesis initiation	R-HSA-174430	7.085429e-01	0.150
Sema3A PAK dependent Axon repulsion	R-HSA-399954	7.085429e-01	0.150
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.100642e-01	0.149
PKR-mediated signaling	R-HSA-9833482	7.100642e-01	0.149
Budding and maturation of HIV virion	R-HSA-162588	7.102335e-01	0.149
Cargo concentration in the ER	R-HSA-5694530	7.102335e-01	0.149
PI Metabolism	R-HSA-1483255	7.114268e-01	0.148
Reproduction	R-HSA-1474165	7.128008e-01	0.147
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	7.132270e-01	0.147
Interferon Signaling	R-HSA-913531	7.166238e-01	0.145
Selective autophagy	R-HSA-9663891	7.183402e-01	0.144
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	7.196527e-01	0.143
MyD88-independent TLR4 cascade	R-HSA-166166	7.196527e-01	0.143
Recycling pathway of L1	R-HSA-437239	7.216532e-01	0.142
Mitochondrial biogenesis	R-HSA-1592230	7.274500e-01	0.138
Regulation of PTEN mRNA translation	R-HSA-8943723	7.287229e-01	0.137
Carnitine shuttle	R-HSA-200425	7.287229e-01	0.137
Syndecan interactions	R-HSA-3000170	7.287229e-01	0.137
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	7.288630e-01	0.137
IFNG signaling activates MAPKs	R-HSA-9732724	7.288630e-01	0.137
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	7.288630e-01	0.137
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	7.288630e-01	0.137
PTK6 Expression	R-HSA-8849473	7.288630e-01	0.137
Synthesis of PIPs in the nucleus	R-HSA-8847453	7.288630e-01	0.137
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	7.288630e-01	0.137
Activated NTRK3 signals through PI3K	R-HSA-9603381	7.288630e-01	0.137
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	7.288630e-01	0.137
VLDL clearance	R-HSA-8964046	7.288630e-01	0.137
Cation-coupled Chloride cotransporters	R-HSA-426117	7.288630e-01	0.137
CHL1 interactions	R-HSA-447041	7.288630e-01	0.137
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	7.293529e-01	0.137
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.296997e-01	0.137
Formation of Incision Complex in GG-NER	R-HSA-5696395	7.326493e-01	0.135
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	7.346270e-01	0.134
Translesion synthesis by POLI	R-HSA-5656121	7.346270e-01	0.134
PPARA activates gene expression	R-HSA-1989781	7.356374e-01	0.133
GPER1 signaling	R-HSA-9634597	7.371784e-01	0.132
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	7.371784e-01	0.132
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	7.448111e-01	0.128
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.475115e-01	0.126
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	7.475357e-01	0.126
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	7.475357e-01	0.126
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	7.489805e-01	0.126
SHC-mediated cascade:FGFR1	R-HSA-5654688	7.493227e-01	0.125
Interleukin-6 family signaling	R-HSA-6783589	7.493227e-01	0.125
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	7.493227e-01	0.125
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	7.493227e-01	0.125
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.508982e-01	0.124
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	7.529597e-01	0.123
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	7.573143e-01	0.121
Regulation of CDH1 Expression and Function	R-HSA-9764265	7.573143e-01	0.121
Translesion synthesis by POLK	R-HSA-5655862	7.586943e-01	0.120
Glycine degradation	R-HSA-6783984	7.586943e-01	0.120
Fibronectin matrix formation	R-HSA-1566977	7.586943e-01	0.120
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	7.586943e-01	0.120
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	7.620486e-01	0.118
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	7.620486e-01	0.118
Activated NTRK2 signals through PI3K	R-HSA-9028335	7.620486e-01	0.118
Activation of RAS in B cells	R-HSA-1169092	7.620486e-01	0.118
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.620486e-01	0.118
Formation of annular gap junctions	R-HSA-196025	7.620486e-01	0.118
ROBO receptors bind AKAP5	R-HSA-9010642	7.620486e-01	0.118
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	7.620486e-01	0.118
TGFBR3 PTM regulation	R-HSA-9839383	7.620486e-01	0.118
Alpha-defensins	R-HSA-1462054	7.620486e-01	0.118
Activated NTRK2 signals through FYN	R-HSA-9032500	7.620486e-01	0.118
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	7.620486e-01	0.118
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	7.645587e-01	0.117
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.647224e-01	0.116
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	7.647224e-01	0.116
Polymerase switching on the C-strand of the telomere	R-HSA-174411	7.686485e-01	0.114
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	7.686485e-01	0.114
VEGFR2 mediated cell proliferation	R-HSA-5218921	7.686485e-01	0.114
Interleukin-7 signaling	R-HSA-1266695	7.686485e-01	0.114
Regulation of beta-cell development	R-HSA-186712	7.692312e-01	0.114
Meiosis	R-HSA-1500620	7.698807e-01	0.114
Axon guidance	R-HSA-422475	7.715812e-01	0.113
Regulated Necrosis	R-HSA-5218859	7.727464e-01	0.112
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	7.757999e-01	0.110
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	7.757999e-01	0.110
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	7.793932e-01	0.108
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.797480e-01	0.108
Elevation of cytosolic Ca2+ levels	R-HSA-139853	7.808477e-01	0.107
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	7.808477e-01	0.107
Regulation of FZD by ubiquitination	R-HSA-4641263	7.808477e-01	0.107
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	7.808477e-01	0.107
Regulation of NPAS4 gene expression	R-HSA-9768759	7.808477e-01	0.107
Uptake and function of anthrax toxins	R-HSA-5210891	7.808477e-01	0.107
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.810035e-01	0.107
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	7.810035e-01	0.107
Signaling by NOTCH2	R-HSA-1980145	7.810035e-01	0.107
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	7.810035e-01	0.107
Mitophagy	R-HSA-5205647	7.810035e-01	0.107
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.841795e-01	0.106
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	7.847206e-01	0.105
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	7.867400e-01	0.104
TRP channels	R-HSA-3295583	7.867400e-01	0.104
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.867400e-01	0.104
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	7.911742e-01	0.102
Gap junction degradation	R-HSA-190873	7.911742e-01	0.102
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.911742e-01	0.102
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	7.911742e-01	0.102
mRNA Editing	R-HSA-75072	7.911742e-01	0.102
Regulation of signaling by NODAL	R-HSA-1433617	7.911742e-01	0.102
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	7.911742e-01	0.102
WNT mediated activation of DVL	R-HSA-201688	7.911742e-01	0.102
Interleukin-1 processing	R-HSA-448706	7.911742e-01	0.102
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.911742e-01	0.102
Butyrophilin (BTN) family interactions	R-HSA-8851680	7.911742e-01	0.102
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	7.930449e-01	0.101
Host Interactions of HIV factors	R-HSA-162909	7.933911e-01	0.101
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.934240e-01	0.100
TBC/RABGAPs	R-HSA-8854214	7.934964e-01	0.100
Nervous system development	R-HSA-9675108	7.936000e-01	0.100
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.940432e-01	0.100
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.948416e-01	0.100
COPII-mediated vesicle transport	R-HSA-204005	7.959480e-01	0.099
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	7.959480e-01	0.099
Oncogene Induced Senescence	R-HSA-2559585	7.963769e-01	0.099
L1CAM interactions	R-HSA-373760	7.976423e-01	0.098
Oxidative Stress Induced Senescence	R-HSA-2559580	7.985870e-01	0.098
Ephrin signaling	R-HSA-3928664	8.011949e-01	0.096
RNA Polymerase III Transcription Termination	R-HSA-73980	8.011949e-01	0.096
Apoptotic factor-mediated response	R-HSA-111471	8.011949e-01	0.096
Mismatch Repair	R-HSA-5358508	8.011949e-01	0.096
PKA activation	R-HSA-163615	8.011949e-01	0.096
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	8.011949e-01	0.096
Influenza Viral RNA Transcription and Replication	R-HSA-168273	8.033233e-01	0.095
Interaction between L1 and Ankyrins	R-HSA-445095	8.036418e-01	0.095
SHC-mediated cascade:FGFR2	R-HSA-5654699	8.036418e-01	0.095
Signaling by FGFR3 in disease	R-HSA-5655332	8.036418e-01	0.095
Signaling by PDGF	R-HSA-186797	8.056681e-01	0.094
Golgi-to-ER retrograde transport	R-HSA-8856688	8.059195e-01	0.094
Cell junction organization	R-HSA-446728	8.065486e-01	0.093
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.068635e-01	0.093
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	8.087277e-01	0.092
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	8.167362e-01	0.088
DNA replication initiation	R-HSA-68952	8.167362e-01	0.088
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	8.167362e-01	0.088
Regulation of CDH11 function	R-HSA-9762292	8.167362e-01	0.088
Arachidonate production from DAG	R-HSA-426048	8.167362e-01	0.088
Apoptosis induced DNA fragmentation	R-HSA-140342	8.167362e-01	0.088
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	8.167362e-01	0.088
Semaphorin interactions	R-HSA-373755	8.167828e-01	0.088
rRNA modification in the nucleus and cytosol	R-HSA-6790901	8.167828e-01	0.088
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	8.167828e-01	0.088
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.173354e-01	0.088
Pyroptosis	R-HSA-5620971	8.194021e-01	0.087
PI-3K cascade:FGFR3	R-HSA-5654710	8.198463e-01	0.086
Crosslinking of collagen fibrils	R-HSA-2243919	8.198463e-01	0.086
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.198463e-01	0.086
Signaling by FGFR2 IIIa TM	R-HSA-8851708	8.198463e-01	0.086
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.198463e-01	0.086
STING mediated induction of host immune responses	R-HSA-1834941	8.198463e-01	0.086
TRAF6 mediated IRF7 activation	R-HSA-933541	8.245040e-01	0.084
Collagen chain trimerization	R-HSA-8948216	8.245040e-01	0.084
Cellular response to starvation	R-HSA-9711097	8.247372e-01	0.084
RSV-host interactions	R-HSA-9833110	8.249798e-01	0.084
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	8.275580e-01	0.082
G alpha (z) signalling events	R-HSA-418597	8.286080e-01	0.082
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.315779e-01	0.080
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	8.315779e-01	0.080
SARS-CoV-2 Infection	R-HSA-9694516	8.334855e-01	0.079
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.340716e-01	0.079
DARPP-32 events	R-HSA-180024	8.340716e-01	0.079
Platelet calcium homeostasis	R-HSA-418360	8.340716e-01	0.079
Regulation of PD-L1(CD274) translation	R-HSA-9909620	8.369119e-01	0.077
PI-3K cascade:FGFR4	R-HSA-5654720	8.369119e-01	0.077
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.369119e-01	0.077
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	8.369119e-01	0.077
Signaling by FGFR in disease	R-HSA-1226099	8.369459e-01	0.077
Signaling by ERBB4	R-HSA-1236394	8.369459e-01	0.077
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.373155e-01	0.077
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.391705e-01	0.076
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	8.391705e-01	0.076
Synthesis of PIPs at the ER membrane	R-HSA-1483248	8.391705e-01	0.076
Ionotropic activity of kainate receptors	R-HSA-451306	8.391705e-01	0.076
LGI-ADAM interactions	R-HSA-5682910	8.391705e-01	0.076
Suppression of apoptosis	R-HSA-9635465	8.391705e-01	0.076
PECAM1 interactions	R-HSA-210990	8.391705e-01	0.076
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.393177e-01	0.076
Signaling by FGFR	R-HSA-190236	8.394304e-01	0.076
Interleukin-1 family signaling	R-HSA-446652	8.415513e-01	0.075
Adherens junctions interactions	R-HSA-418990	8.426507e-01	0.074
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.429254e-01	0.074
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	8.459500e-01	0.073
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.493338e-01	0.071
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	8.493338e-01	0.071
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.494566e-01	0.071
PKA-mediated phosphorylation of CREB	R-HSA-111931	8.525005e-01	0.069
tRNA processing	R-HSA-72306	8.531907e-01	0.069
MAPK6/MAPK4 signaling	R-HSA-5687128	8.543038e-01	0.068
EPH-Ephrin signaling	R-HSA-2682334	8.544144e-01	0.068
Signaling by Insulin receptor	R-HSA-74752	8.544144e-01	0.068
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	8.588597e-01	0.066
PI3K events in ERBB4 signaling	R-HSA-1250342	8.588597e-01	0.066
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.588597e-01	0.066
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.588597e-01	0.066
Reduction of cytosolic Ca++ levels	R-HSA-418359	8.588597e-01	0.066
DS-GAG biosynthesis	R-HSA-2022923	8.588597e-01	0.066
Integration of provirus	R-HSA-162592	8.588597e-01	0.066
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	8.603490e-01	0.065
Interleukin-2 family signaling	R-HSA-451927	8.605917e-01	0.065
Nuclear signaling by ERBB4	R-HSA-1251985	8.605917e-01	0.065
Assembly of the pre-replicative complex	R-HSA-68867	8.620669e-01	0.064
Extra-nuclear estrogen signaling	R-HSA-9009391	8.623616e-01	0.064
DNA Replication Pre-Initiation	R-HSA-69002	8.630519e-01	0.064
DNA Damage Bypass	R-HSA-73893	8.637289e-01	0.064
Regulation of T cell activation by CD28 family	R-HSA-388841	8.646327e-01	0.063
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	8.667178e-01	0.062
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.667178e-01	0.062
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	8.667178e-01	0.062
Molybdenum cofactor biosynthesis	R-HSA-947581	8.667178e-01	0.062
Mitochondrial calcium ion transport	R-HSA-8949215	8.667178e-01	0.062
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.682270e-01	0.061
Cell-Cell communication	R-HSA-1500931	8.703123e-01	0.060
HCMV Late Events	R-HSA-9610379	8.716232e-01	0.060
DNA strand elongation	R-HSA-69190	8.720637e-01	0.059
Signaling by FGFR2 in disease	R-HSA-5655253	8.732310e-01	0.059
Developmental Biology	R-HSA-1266738	8.755980e-01	0.058
Polymerase switching	R-HSA-69091	8.761395e-01	0.057
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	8.761395e-01	0.057
Leading Strand Synthesis	R-HSA-69109	8.761395e-01	0.057
GRB2 events in EGFR signaling	R-HSA-179812	8.761395e-01	0.057
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.761395e-01	0.057
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.761395e-01	0.057
VLDLR internalisation and degradation	R-HSA-8866427	8.761395e-01	0.057
Role of second messengers in netrin-1 signaling	R-HSA-418890	8.761395e-01	0.057
OAS antiviral response	R-HSA-8983711	8.761395e-01	0.057
Co-inhibition by PD-1	R-HSA-389948	8.761746e-01	0.057
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	8.790415e-01	0.056
PI-3K cascade:FGFR1	R-HSA-5654689	8.796659e-01	0.056
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.796659e-01	0.056
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.796659e-01	0.056
Degradation of CRY and PER proteins	R-HSA-9932298	8.809599e-01	0.055
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.809599e-01	0.055
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.812166e-01	0.055
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	8.812166e-01	0.055
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	8.826159e-01	0.054
Response of endothelial cells to shear stress	R-HSA-9860931	8.826159e-01	0.054
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	8.828999e-01	0.054
FGFR1 mutant receptor activation	R-HSA-1839124	8.828999e-01	0.054
Diseases of programmed cell death	R-HSA-9645723	8.841622e-01	0.053
Formation of paraxial mesoderm	R-HSA-9793380	8.849885e-01	0.053
PLC beta mediated events	R-HSA-112043	8.849885e-01	0.053
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	8.905546e-01	0.050
Orc1 removal from chromatin	R-HSA-68949	8.905546e-01	0.050
Adenylate cyclase activating pathway	R-HSA-170660	8.913046e-01	0.050
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	8.913046e-01	0.050
Platelet Adhesion to exposed collagen	R-HSA-75892	8.913046e-01	0.050
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.913046e-01	0.050
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.913046e-01	0.050
CD28 dependent Vav1 pathway	R-HSA-389359	8.913046e-01	0.050
Processing of SMDT1	R-HSA-8949664	8.913046e-01	0.050
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.913046e-01	0.050
Maturation of nucleoprotein	R-HSA-9683610	8.913046e-01	0.050
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.913046e-01	0.050
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	8.914424e-01	0.050
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	8.914424e-01	0.050
Growth hormone receptor signaling	R-HSA-982772	8.914424e-01	0.050
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	8.929099e-01	0.049
Glucagon signaling in metabolic regulation	R-HSA-163359	8.929099e-01	0.049
Miscellaneous transport and binding events	R-HSA-5223345	8.929099e-01	0.049
Cellular responses to mechanical stimuli	R-HSA-9855142	8.942676e-01	0.049
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	8.984245e-01	0.047
Influenza Infection	R-HSA-168255	8.991188e-01	0.046
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.021448e-01	0.045
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	9.021448e-01	0.045
NOD1/2 Signaling Pathway	R-HSA-168638	9.021448e-01	0.045
Ca2+ pathway	R-HSA-4086398	9.023885e-01	0.045
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.034462e-01	0.044
Maternal to zygotic transition (MZT)	R-HSA-9816359	9.045865e-01	0.044
Removal of the Flap Intermediate	R-HSA-69166	9.046137e-01	0.044
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	9.046137e-01	0.044
NRIF signals cell death from the nucleus	R-HSA-205043	9.046137e-01	0.044
CRMPs in Sema3A signaling	R-HSA-399956	9.046137e-01	0.044
Physiological factors	R-HSA-5578768	9.046137e-01	0.044
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	9.046137e-01	0.044
HDL assembly	R-HSA-8963896	9.046137e-01	0.044
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	9.046137e-01	0.044
Cytoprotection by HMOX1	R-HSA-9707564	9.054340e-01	0.043
Synthesis of DNA	R-HSA-69239	9.057824e-01	0.043
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.066500e-01	0.043
Signaling by NOTCH4	R-HSA-9013694	9.086918e-01	0.042
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.106542e-01	0.041
PERK regulates gene expression	R-HSA-381042	9.106542e-01	0.041
PI-3K cascade:FGFR2	R-HSA-5654695	9.118464e-01	0.040
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.118464e-01	0.040
Laminin interactions	R-HSA-3000157	9.118464e-01	0.040
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.118464e-01	0.040
Toll-like Receptor Cascades	R-HSA-168898	9.123693e-01	0.040
Fanconi Anemia Pathway	R-HSA-6783310	9.140498e-01	0.039
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.140498e-01	0.039
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.146427e-01	0.039
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.146427e-01	0.039
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	9.162938e-01	0.038
Adenylate cyclase inhibitory pathway	R-HSA-170670	9.162938e-01	0.038
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	9.162938e-01	0.038
RNA Polymerase III Chain Elongation	R-HSA-73780	9.162938e-01	0.038
G beta:gamma signalling through BTK	R-HSA-8964315	9.162938e-01	0.038
Processive synthesis on the lagging strand	R-HSA-69183	9.162938e-01	0.038
Protein lipoylation	R-HSA-9857492	9.162938e-01	0.038
DNA Damage Reversal	R-HSA-73942	9.162938e-01	0.038
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	9.162938e-01	0.038
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	9.162938e-01	0.038
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	9.162938e-01	0.038
Lysosphingolipid and LPA receptors	R-HSA-419408	9.162938e-01	0.038
p38MAPK events	R-HSA-171007	9.162938e-01	0.038
IRF3-mediated induction of type I IFN	R-HSA-3270619	9.162938e-01	0.038
Protein methylation	R-HSA-8876725	9.162938e-01	0.038
PRC2 methylates histones and DNA	R-HSA-212300	9.184858e-01	0.037
Triglyceride catabolism	R-HSA-163560	9.184858e-01	0.037
SARS-CoV-1 Infection	R-HSA-9678108	9.186513e-01	0.037
MET activates PTK2 signaling	R-HSA-8874081	9.206438e-01	0.036
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	9.206438e-01	0.036
Urea cycle	R-HSA-70635	9.206438e-01	0.036
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.206438e-01	0.036
Potential therapeutics for SARS	R-HSA-9679191	9.218074e-01	0.035
Signaling by ROBO receptors	R-HSA-376176	9.238273e-01	0.034
G-protein mediated events	R-HSA-112040	9.248177e-01	0.034
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.256176e-01	0.034
Degradation of AXIN	R-HSA-4641257	9.256856e-01	0.034
Defective GALNT3 causes HFTC	R-HSA-5083625	9.265444e-01	0.033
Defective GALNT12 causes CRCS1	R-HSA-5083636	9.265444e-01	0.033
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	9.265444e-01	0.033
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	9.265444e-01	0.033
Killing mechanisms	R-HSA-9664420	9.265444e-01	0.033
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	9.265444e-01	0.033
Regulation of NF-kappa B signaling	R-HSA-9758274	9.265444e-01	0.033
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	9.265444e-01	0.033
XBP1(S) activates chaperone genes	R-HSA-381038	9.269699e-01	0.033
Synthesis of PC	R-HSA-1483191	9.272960e-01	0.033
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.276763e-01	0.033
EPHA-mediated growth cone collapse	R-HSA-3928663	9.286092e-01	0.032
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	9.286092e-01	0.032
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.292520e-01	0.032
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.292520e-01	0.032
HCMV Early Events	R-HSA-9609690	9.298591e-01	0.032
PCP/CE pathway	R-HSA-4086400	9.305275e-01	0.031
Dual incision in TC-NER	R-HSA-6782135	9.308085e-01	0.031
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.322976e-01	0.030
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	9.350950e-01	0.029
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.355401e-01	0.029
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	9.355401e-01	0.029
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	9.355401e-01	0.029
Acetylcholine regulates insulin secretion	R-HSA-399997	9.355401e-01	0.029
Coenzyme A biosynthesis	R-HSA-196783	9.355401e-01	0.029
Passive transport by Aquaporins	R-HSA-432047	9.355401e-01	0.029
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.355401e-01	0.029
Scavenging by Class B Receptors	R-HSA-3000471	9.355401e-01	0.029
Synthesis of PG	R-HSA-1483148	9.355401e-01	0.029
tRNA modification in the mitochondrion	R-HSA-6787450	9.355401e-01	0.029
Chromosome Maintenance	R-HSA-73886	9.356919e-01	0.029
Telomere Extension By Telomerase	R-HSA-171319	9.358144e-01	0.029
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.358144e-01	0.029
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.358144e-01	0.029
Cell-cell junction organization	R-HSA-421270	9.385590e-01	0.028
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	9.416608e-01	0.026
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.423261e-01	0.026
Glucagon-type ligand receptors	R-HSA-420092	9.423261e-01	0.026
MHC class II antigen presentation	R-HSA-2132295	9.427184e-01	0.026
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	9.434347e-01	0.025
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	9.434347e-01	0.025
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.434347e-01	0.025
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	9.434347e-01	0.025
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.434347e-01	0.025
Regulation of RAS by GAPs	R-HSA-5658442	9.437308e-01	0.025
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.439230e-01	0.025
Attenuation phase	R-HSA-3371568	9.439230e-01	0.025
Inhibition of DNA recombination at telomere	R-HSA-9670095	9.439230e-01	0.025
Aggrephagy	R-HSA-9646399	9.439230e-01	0.025
Diseases of Immune System	R-HSA-5260271	9.439230e-01	0.025
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.439230e-01	0.025
Aquaporin-mediated transport	R-HSA-445717	9.454853e-01	0.024
Collagen degradation	R-HSA-1442490	9.454853e-01	0.024
Cytokine Signaling in Immune system	R-HSA-1280215	9.465637e-01	0.024
SLC transporter disorders	R-HSA-5619102	9.476503e-01	0.023
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.482061e-01	0.023
Meiotic recombination	R-HSA-912446	9.484051e-01	0.023
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.490137e-01	0.023
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.490137e-01	0.023
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	9.490137e-01	0.023
Resolution of Abasic Sites (AP sites)	R-HSA-73933	9.490137e-01	0.023
SARS-CoV Infections	R-HSA-9679506	9.490426e-01	0.023
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.494265e-01	0.023
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.494265e-01	0.023
GAB1 signalosome	R-HSA-180292	9.503628e-01	0.022
Chaperone Mediated Autophagy	R-HSA-9613829	9.503628e-01	0.022
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.503628e-01	0.022
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.503628e-01	0.022
Platelet sensitization by LDL	R-HSA-432142	9.503628e-01	0.022
IRE1alpha activates chaperones	R-HSA-381070	9.512745e-01	0.022
RNA Polymerase I Promoter Escape	R-HSA-73772	9.527207e-01	0.021
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.536708e-01	0.021
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.536708e-01	0.021
Interleukin-1 signaling	R-HSA-9020702	9.548464e-01	0.020
Translesion Synthesis by POLH	R-HSA-110320	9.564427e-01	0.019
IKK complex recruitment mediated by RIP1	R-HSA-937041	9.564427e-01	0.019
Diseases of hemostasis	R-HSA-9671793	9.564427e-01	0.019
Maturation of nucleoprotein	R-HSA-9694631	9.564427e-01	0.019
The NLRP3 inflammasome	R-HSA-844456	9.564427e-01	0.019
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.564427e-01	0.019
Cleavage of the damaged pyrimidine	R-HSA-110329	9.579278e-01	0.019
Depyrimidination	R-HSA-73928	9.579278e-01	0.019
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	9.603711e-01	0.018
Cellular response to hypoxia	R-HSA-1234174	9.606687e-01	0.017
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.608935e-01	0.017
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.617782e-01	0.017
Creatine metabolism	R-HSA-71288	9.617782e-01	0.017
Pregnenolone biosynthesis	R-HSA-196108	9.617782e-01	0.017
Vesicle-mediated transport	R-HSA-5653656	9.621941e-01	0.017
Assembly of the ORC complex at the origin of replication	R-HSA-68616	9.626038e-01	0.017
Opioid Signalling	R-HSA-111885	9.631229e-01	0.016
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.638034e-01	0.016
Amine ligand-binding receptors	R-HSA-375280	9.653637e-01	0.015
ER to Golgi Anterograde Transport	R-HSA-199977	9.662941e-01	0.015
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.664604e-01	0.015
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.664604e-01	0.015
Lagging Strand Synthesis	R-HSA-69186	9.664604e-01	0.015
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	9.664604e-01	0.015
Basigin interactions	R-HSA-210991	9.664604e-01	0.015
Early Phase of HIV Life Cycle	R-HSA-162594	9.664604e-01	0.015
Striated Muscle Contraction	R-HSA-390522	9.664834e-01	0.015
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.664834e-01	0.015
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.664834e-01	0.015
Ion homeostasis	R-HSA-5578775	9.668602e-01	0.015
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.668602e-01	0.015
Interleukin-10 signaling	R-HSA-6783783	9.674679e-01	0.014
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.680974e-01	0.014
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.685991e-01	0.014
Asymmetric localization of PCP proteins	R-HSA-4608870	9.685991e-01	0.014
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.685991e-01	0.014
Somitogenesis	R-HSA-9824272	9.685991e-01	0.014
Parasite infection	R-HSA-9664407	9.693354e-01	0.014
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.693354e-01	0.014
Leishmania phagocytosis	R-HSA-9664417	9.693354e-01	0.014
Dual Incision in GG-NER	R-HSA-5696400	9.699740e-01	0.013
eNOS activation	R-HSA-203615	9.699740e-01	0.013
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.699740e-01	0.013
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.705693e-01	0.013
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	9.705693e-01	0.013
Assembly Of The HIV Virion	R-HSA-175474	9.705693e-01	0.013
Glutathione synthesis and recycling	R-HSA-174403	9.705693e-01	0.013
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.711540e-01	0.013
HCMV Infection	R-HSA-9609646	9.711875e-01	0.013
Cellular responses to stress	R-HSA-2262752	9.716269e-01	0.013
Interferon alpha/beta signaling	R-HSA-909733	9.719538e-01	0.012
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.723476e-01	0.012
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	9.731127e-01	0.012
Cap-dependent Translation Initiation	R-HSA-72737	9.737907e-01	0.012
Eukaryotic Translation Initiation	R-HSA-72613	9.737907e-01	0.012
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.741750e-01	0.011
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.741750e-01	0.011
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.741750e-01	0.011
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.741750e-01	0.011
Ethanol oxidation	R-HSA-71384	9.741750e-01	0.011
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.741750e-01	0.011
Signaling by KIT in disease	R-HSA-9669938	9.741750e-01	0.011
LDL clearance	R-HSA-8964038	9.741750e-01	0.011
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.742317e-01	0.011
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	9.742317e-01	0.011
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.747385e-01	0.011
Extension of Telomeres	R-HSA-180786	9.747605e-01	0.011
Triglyceride metabolism	R-HSA-8979227	9.747605e-01	0.011
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.749858e-01	0.011
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.759332e-01	0.011
FGFR2 mutant receptor activation	R-HSA-1839126	9.759332e-01	0.011
Signaling by Retinoic Acid	R-HSA-5362517	9.769745e-01	0.010
Termination of O-glycan biosynthesis	R-HSA-977068	9.773391e-01	0.010
Organic anion transport by SLCO transporters	R-HSA-879518	9.773391e-01	0.010
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.773391e-01	0.010
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.784664e-01	0.009
NCAM1 interactions	R-HSA-419037	9.784664e-01	0.009
SLC-mediated transport of organic cations	R-HSA-549127	9.784664e-01	0.009
Metabolism of folate and pterines	R-HSA-196757	9.784664e-01	0.009
Integration of energy metabolism	R-HSA-163685	9.786678e-01	0.009
Beta-catenin independent WNT signaling	R-HSA-3858494	9.786678e-01	0.009
Degradation of CDH1	R-HSA-9766229	9.788959e-01	0.009
Signaling by Interleukins	R-HSA-449147	9.789673e-01	0.009
Complex III assembly	R-HSA-9865881	9.801158e-01	0.009
Mitochondrial RNA degradation	R-HSA-9836573	9.801158e-01	0.009
TNFs bind their physiological receptors	R-HSA-5669034	9.801158e-01	0.009
Plasma lipoprotein assembly	R-HSA-8963898	9.801158e-01	0.009
Mitochondrial protein import	R-HSA-1268020	9.808654e-01	0.008
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.808654e-01	0.008
NCAM signaling for neurite out-growth	R-HSA-375165	9.808654e-01	0.008
Cellular response to chemical stress	R-HSA-9711123	9.812977e-01	0.008
Unfolded Protein Response (UPR)	R-HSA-381119	9.824759e-01	0.008
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.825523e-01	0.008
Activation of G protein gated Potassium channels	R-HSA-1296041	9.825523e-01	0.008
G protein gated Potassium channels	R-HSA-1296059	9.825523e-01	0.008
Tight junction interactions	R-HSA-420029	9.825523e-01	0.008
Acyl chain remodelling of PS	R-HSA-1482801	9.825523e-01	0.008
Beta-oxidation of pristanoyl-CoA	R-HSA-389887	9.825523e-01	0.008
Alpha-oxidation of phytanate	R-HSA-389599	9.825523e-01	0.008
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.825523e-01	0.008
Activation of NF-kappaB in B cells	R-HSA-1169091	9.827480e-01	0.008
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.827480e-01	0.008
Hedgehog ligand biogenesis	R-HSA-5358346	9.827480e-01	0.008
Stabilization of p53	R-HSA-69541	9.827806e-01	0.008
Plasma lipoprotein clearance	R-HSA-8964043	9.827806e-01	0.008
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.831820e-01	0.007
Interferon gamma signaling	R-HSA-877300	9.837744e-01	0.007
Ion transport by P-type ATPases	R-HSA-936837	9.841289e-01	0.007
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	9.841289e-01	0.007
Transcriptional Regulation by NPAS4	R-HSA-9634815	9.844122e-01	0.007
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.846101e-01	0.007
Suppression of phagosomal maturation	R-HSA-9637687	9.846904e-01	0.007
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.846904e-01	0.007
Attachment of bacteria to epithelial cells	R-HSA-9638630	9.846904e-01	0.007
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	9.846904e-01	0.007
COPI-mediated anterograde transport	R-HSA-6807878	9.856598e-01	0.006
Maturation of spike protein	R-HSA-9694548	9.862499e-01	0.006
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.865666e-01	0.006
Packaging Of Telomere Ends	R-HSA-171306	9.865666e-01	0.006
RNA Polymerase I Promoter Opening	R-HSA-73728	9.865666e-01	0.006
Cristae formation	R-HSA-8949613	9.865666e-01	0.006
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.865666e-01	0.006
Triglyceride biosynthesis	R-HSA-75109	9.865666e-01	0.006
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.865666e-01	0.006
Synthesis of PE	R-HSA-1483213	9.865666e-01	0.006
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.865666e-01	0.006
Insulin processing	R-HSA-264876	9.865666e-01	0.006
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.872907e-01	0.006
DNA Replication	R-HSA-69306	9.874066e-01	0.006
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.877191e-01	0.005
Intra-Golgi traffic	R-HSA-6811438	9.877191e-01	0.005
Heme biosynthesis	R-HSA-189451	9.877191e-01	0.005
Scavenging by Class A Receptors	R-HSA-3000480	9.877191e-01	0.005
Stimuli-sensing channels	R-HSA-2672351	9.879651e-01	0.005
Kidney development	R-HSA-9830369	9.880512e-01	0.005
Phase 0 - rapid depolarisation	R-HSA-5576892	9.882130e-01	0.005
Activation of kainate receptors upon glutamate binding	R-HSA-451326	9.882130e-01	0.005
Insulin receptor recycling	R-HSA-77387	9.882130e-01	0.005
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.882130e-01	0.005
Iron assimilation using enterobactin	R-HSA-9638334	9.882130e-01	0.005
Inflammasomes	R-HSA-622312	9.882130e-01	0.005
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.885310e-01	0.005
Neurotransmitter release cycle	R-HSA-112310	9.888475e-01	0.005
GABA B receptor activation	R-HSA-977444	9.890348e-01	0.005
Activation of GABAB receptors	R-HSA-991365	9.890348e-01	0.005
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	9.890348e-01	0.005
Cytosolic tRNA aminoacylation	R-HSA-379716	9.890348e-01	0.005
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.891393e-01	0.005
Thyroxine biosynthesis	R-HSA-209968	9.896577e-01	0.005
DNA methylation	R-HSA-5334118	9.896577e-01	0.005
Activation of Matrix Metalloproteinases	R-HSA-1592389	9.896577e-01	0.005
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.896577e-01	0.005
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.896577e-01	0.005
Defective pyroptosis	R-HSA-9710421	9.902126e-01	0.004
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.902126e-01	0.004
Response of Mtb to phagocytosis	R-HSA-9637690	9.902126e-01	0.004
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.906035e-01	0.004
Regulation of CDH1 Function	R-HSA-9764561	9.906713e-01	0.004
Neurotransmitter clearance	R-HSA-112311	9.909254e-01	0.004
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.909881e-01	0.004
Proteasome assembly	R-HSA-9907900	9.912665e-01	0.004
Surfactant metabolism	R-HSA-5683826	9.912665e-01	0.004
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.913585e-01	0.004
Eukaryotic Translation Elongation	R-HSA-156842	9.913801e-01	0.004
Cellular responses to stimuli	R-HSA-8953897	9.914382e-01	0.004
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.915134e-01	0.004
Platelet activation, signaling and aggregation	R-HSA-76002	9.915536e-01	0.004
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.918242e-01	0.004
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.920377e-01	0.003
Molecules associated with elastic fibres	R-HSA-2129379	9.920377e-01	0.003
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.920956e-01	0.003
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.922091e-01	0.003
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.922091e-01	0.003
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.922091e-01	0.003
Peroxisomal protein import	R-HSA-9033241	9.924236e-01	0.003
Amino acid transport across the plasma membrane	R-HSA-352230	9.924236e-01	0.003
Transmission across Chemical Synapses	R-HSA-112315	9.924395e-01	0.003
Collagen formation	R-HSA-1474290	9.927546e-01	0.003
Inwardly rectifying K+ channels	R-HSA-1296065	9.930138e-01	0.003
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.930138e-01	0.003
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	9.930138e-01	0.003
Regulation of pyruvate metabolism	R-HSA-9861718	9.930520e-01	0.003
tRNA Aminoacylation	R-HSA-379724	9.931758e-01	0.003
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.932906e-01	0.003
Neddylation	R-HSA-8951664	9.935519e-01	0.003
Recycling of bile acids and salts	R-HSA-159418	9.938703e-01	0.003
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.938703e-01	0.003
Formation of a pool of free 40S subunits	R-HSA-72689	9.939191e-01	0.003
ROS and RNS production in phagocytes	R-HSA-1222556	9.939268e-01	0.003
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.941137e-01	0.003
Platelet homeostasis	R-HSA-418346	9.942023e-01	0.003
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.943295e-01	0.002
Metal ion SLC transporters	R-HSA-425410	9.944785e-01	0.002
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.944948e-01	0.002
Acyl chain remodelling of PC	R-HSA-1482788	9.946218e-01	0.002
Vpu mediated degradation of CD4	R-HSA-180534	9.946218e-01	0.002
Chaperonin-mediated protein folding	R-HSA-390466	9.948441e-01	0.002
Telomere Maintenance	R-HSA-157579	9.949041e-01	0.002
Gap junction trafficking and regulation	R-HSA-157858	9.950797e-01	0.002
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.950797e-01	0.002
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.952812e-01	0.002
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.952812e-01	0.002
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.952812e-01	0.002
Calnexin/calreticulin cycle	R-HSA-901042	9.952812e-01	0.002
Hyaluronan metabolism	R-HSA-2142845	9.952812e-01	0.002
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.952812e-01	0.002
NPAS4 regulates expression of target genes	R-HSA-9768919	9.952812e-01	0.002
Peptide chain elongation	R-HSA-156902	9.953034e-01	0.002
Azathioprine ADME	R-HSA-9748787	9.956165e-01	0.002
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.958598e-01	0.002
Acyl chain remodelling of PE	R-HSA-1482839	9.958598e-01	0.002
Regulation of Apoptosis	R-HSA-169911	9.958598e-01	0.002
Transferrin endocytosis and recycling	R-HSA-917977	9.958598e-01	0.002
Downstream TCR signaling	R-HSA-202424	9.961071e-01	0.002
Class B/2 (Secretin family receptors)	R-HSA-373080	9.961071e-01	0.002
HSF1 activation	R-HSA-3371511	9.963675e-01	0.002
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.963675e-01	0.002
Glycosphingolipid transport	R-HSA-9845576	9.963675e-01	0.002
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.964576e-01	0.002
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	9.965234e-01	0.002
Uptake and actions of bacterial toxins	R-HSA-5339562	9.965234e-01	0.002
Nicotinate metabolism	R-HSA-196807	9.967480e-01	0.001
SLC-mediated transport of amino acids	R-HSA-9958863	9.967480e-01	0.001
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.968129e-01	0.001
Degradation of DVL	R-HSA-4641258	9.968129e-01	0.001
Cleavage of the damaged purine	R-HSA-110331	9.968129e-01	0.001
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.968129e-01	0.001
Smooth Muscle Contraction	R-HSA-445355	9.969049e-01	0.001
Golgi Associated Vesicle Biogenesis	R-HSA-432722	9.969049e-01	0.001
Protein folding	R-HSA-391251	9.970697e-01	0.001
Formation of the cornified envelope	R-HSA-6809371	9.972024e-01	0.001
Depurination	R-HSA-73927	9.972038e-01	0.001
alpha-linolenic acid (ALA) metabolism	R-HSA-2046106	9.972038e-01	0.001
Elastic fibre formation	R-HSA-1566948	9.972038e-01	0.001
Biofilm formation	R-HSA-9931953	9.972038e-01	0.001
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.975467e-01	0.001
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.975467e-01	0.001
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.975467e-01	0.001
Pentose phosphate pathway	R-HSA-71336	9.975467e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.976438e-01	0.001
Generation of second messenger molecules	R-HSA-202433	9.978476e-01	0.001
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.978476e-01	0.001
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.978476e-01	0.001
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.978849e-01	0.001
Metabolism of cofactors	R-HSA-8978934	9.978849e-01	0.001
Eukaryotic Translation Termination	R-HSA-72764	9.980026e-01	0.001
Synthesis of PA	R-HSA-1483166	9.980599e-01	0.001
Hh mutants are degraded by ERAD	R-HSA-5362768	9.981116e-01	0.001
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.981184e-01	0.001
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.983433e-01	0.001
Translation of Structural Proteins	R-HSA-9683701	9.983433e-01	0.001
Developmental Cell Lineages	R-HSA-9734767	9.983893e-01	0.001
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.984620e-01	0.001
G alpha (s) signalling events	R-HSA-418555	9.984738e-01	0.001
C-type lectin receptors (CLRs)	R-HSA-5621481	9.984738e-01	0.001
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.985465e-01	0.001
TCR signaling	R-HSA-202403	9.985756e-01	0.001
Phospholipid metabolism	R-HSA-1483257	9.985814e-01	0.001
Citric acid cycle (TCA cycle)	R-HSA-71403	9.986302e-01	0.001
Protein ubiquitination	R-HSA-8852135	9.986302e-01	0.001
GABA receptor activation	R-HSA-977443	9.986361e-01	0.001
Metabolism of polyamines	R-HSA-351202	9.986361e-01	0.001
Neuronal System	R-HSA-112316	9.986647e-01	0.001
Defensins	R-HSA-1461973	9.987248e-01	0.001
Endogenous sterols	R-HSA-211976	9.987877e-01	0.001
Disorders of transmembrane transporters	R-HSA-5619115	9.987885e-01	0.001
Protein localization	R-HSA-9609507	9.988123e-01	0.001
FCERI mediated MAPK activation	R-HSA-2871796	9.988185e-01	0.001
Gap junction trafficking	R-HSA-190828	9.988813e-01	0.000
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.988813e-01	0.000
Selenocysteine synthesis	R-HSA-2408557	9.988860e-01	0.000
Translation of Structural Proteins	R-HSA-9694635	9.988993e-01	0.000
Base Excision Repair	R-HSA-73884	9.989053e-01	0.000
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.990185e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.990428e-01	0.000
Viral mRNA Translation	R-HSA-192823	9.990851e-01	0.000
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.991164e-01	0.000
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.991390e-01	0.000
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.991390e-01	0.000
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.991390e-01	0.000
Adaptive Immune System	R-HSA-1280218	9.992205e-01	0.000
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.992446e-01	0.000
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	R-HSA-2046104	9.992446e-01	0.000
Transport to the Golgi and subsequent modification	R-HSA-948021	9.992475e-01	0.000
Platelet degranulation	R-HSA-114608	9.993036e-01	0.000
Intraflagellar transport	R-HSA-5620924	9.993373e-01	0.000
Gluconeogenesis	R-HSA-70263	9.993373e-01	0.000
Ribosome-associated quality control	R-HSA-9948299	9.993586e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.994044e-01	0.000
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.994186e-01	0.000
Chemokine receptors bind chemokines	R-HSA-380108	9.994186e-01	0.000
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.994712e-01	0.000
Antigen processing-Cross presentation	R-HSA-1236975	9.994963e-01	0.000
Complex IV assembly	R-HSA-9864848	9.995526e-01	0.000
The phototransduction cascade	R-HSA-2514856	9.995526e-01	0.000
Regulation of insulin secretion	R-HSA-422356	9.996151e-01	0.000
rRNA processing	R-HSA-72312	9.996277e-01	0.000
ECM proteoglycans	R-HSA-3000178	9.996303e-01	0.000
Metabolism of porphyrins	R-HSA-189445	9.996303e-01	0.000
Ion channel transport	R-HSA-983712	9.996331e-01	0.000
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.996720e-01	0.000
ABC-family proteins mediated transport	R-HSA-382556	9.996885e-01	0.000
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.997350e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.997676e-01	0.000
Iron uptake and transport	R-HSA-917937	9.997710e-01	0.000
Dectin-2 family	R-HSA-5621480	9.997961e-01	0.000
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.998344e-01	0.000
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.998344e-01	0.000
ABC transporter disorders	R-HSA-5619084	9.998404e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.998404e-01	0.000
Integrin cell surface interactions	R-HSA-216083	9.998404e-01	0.000
Cholesterol biosynthesis	R-HSA-191273	9.998404e-01	0.000
RAB geranylgeranylation	R-HSA-8873719	9.998624e-01	0.000
Glutathione conjugation	R-HSA-156590	9.998624e-01	0.000
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.998624e-01	0.000
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.998948e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999061e-01	0.000
Xenobiotics	R-HSA-211981	9.999185e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999227e-01	0.000
Post-translational protein phosphorylation	R-HSA-8957275	9.999252e-01	0.000
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.999285e-01	0.000
Metabolism of steroid hormones	R-HSA-196071	9.999450e-01	0.000
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.999514e-01	0.000
O-linked glycosylation of mucins	R-HSA-913709	9.999518e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.999524e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999579e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999588e-01	0.000
ER-Phagosome pathway	R-HSA-1236974	9.999627e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.999674e-01	0.000
Cardiac conduction	R-HSA-5576891	9.999689e-01	0.000
Purine catabolism	R-HSA-74259	9.999714e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.999721e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999750e-01	0.000
Parasitic Infection Pathways	R-HSA-9824443	9.999806e-01	0.000
Leishmania infection	R-HSA-9658195	9.999806e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.999821e-01	0.000
Interleukin-12 signaling	R-HSA-9020591	9.999831e-01	0.000
Selenoamino acid metabolism	R-HSA-2408522	9.999852e-01	0.000
Potassium Channels	R-HSA-1296071	9.999876e-01	0.000
G alpha (q) signalling events	R-HSA-416476	9.999883e-01	0.000
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.999886e-01	0.000
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999906e-01	0.000
Amyloid fiber formation	R-HSA-977225	9.999912e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999914e-01	0.000
Viral Infection Pathways	R-HSA-9824446	9.999921e-01	0.000
Hemostasis	R-HSA-109582	9.999929e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.999938e-01	0.000
Interleukin-12 family signaling	R-HSA-447115	9.999965e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999980e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999983e-01	0.000
Muscle contraction	R-HSA-397014	9.999985e-01	0.000
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999989e-01	0.000
Keratinization	R-HSA-6805567	9.999993e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999994e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999996e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999998e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999998e-01	0.000
Nucleotide catabolism	R-HSA-8956319	9.999999e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999999e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999999e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999999e-01	0.000
Diseases of glycosylation	R-HSA-3781865	9.999999e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999999e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999999e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	1.000000e+00	0.000
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	1.000000e+00	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	1.000000e+00	0.000
Leishmania parasite growth and survival	R-HSA-9664433	1.000000e+00	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
O-linked glycosylation	R-HSA-5173105	1.000000e+00	0.000
Immune System	R-HSA-168256	1.000000e+00	0.000
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000
Neutrophil degranulation	R-HSA-6798695	1.000000e+00	0.000
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000
Extracellular matrix organization	R-HSA-1474244	1.000000e+00	0.000
Visual phototransduction	R-HSA-2187338	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Translation	R-HSA-72766	1.000000e+00	0.000
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Sphingolipid metabolism	R-HSA-428157	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000
Infectious disease	R-HSA-5663205	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Innate Immune System	R-HSA-168249	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Disease	R-HSA-1643685	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	-0.000
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p
Cell Cycle	R-HSA-1640170	1.210809e-12	11.917
Chromatin organization	R-HSA-4839726	2.979034e-10	9.526
Cell Cycle, Mitotic	R-HSA-69278	3.131330e-10	9.504
Chromatin modifying enzymes	R-HSA-3247509	9.152409e-10	9.038
G2/M DNA damage checkpoint	R-HSA-69473	2.992689e-08	7.524
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	4.874715e-08	7.312
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	8.068950e-08	7.093
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	8.821884e-08	7.054
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.496402e-07	6.825
Oxidative Stress Induced Senescence	R-HSA-2559580	1.580368e-07	6.801
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.263471e-07	6.645
mRNA Splicing - Major Pathway	R-HSA-72163	2.556254e-07	6.592
G2/M Checkpoints	R-HSA-69481	2.905566e-07	6.537
Cellular Senescence	R-HSA-2559583	3.981434e-07	6.400
mRNA Splicing	R-HSA-72172	5.256476e-07	6.279
Transcriptional regulation of granulopoiesis	R-HSA-9616222	5.176458e-07	6.286
Membrane Trafficking	R-HSA-199991	6.800583e-07	6.167
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	7.497445e-07	6.125
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	7.815519e-07	6.107
Condensation of Prophase Chromosomes	R-HSA-2299718	8.686157e-07	6.061
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.070122e-06	5.971
Cell Cycle Checkpoints	R-HSA-69620	1.152829e-06	5.938
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.553148e-06	5.809
Estrogen-dependent gene expression	R-HSA-9018519	1.821145e-06	5.740
M Phase	R-HSA-68886	2.034318e-06	5.692
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.267624e-06	5.486
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	4.349333e-06	5.362
Defective pyroptosis	R-HSA-9710421	4.655227e-06	5.332
HATs acetylate histones	R-HSA-3214847	4.772822e-06	5.321
PRC2 methylates histones and DNA	R-HSA-212300	5.755972e-06	5.240
Meiotic synapsis	R-HSA-1221632	5.900178e-06	5.229
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	5.900178e-06	5.229
DNA methylation	R-HSA-5334118	6.417468e-06	5.193
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	8.018383e-06	5.096
Signal Transduction	R-HSA-162582	7.919656e-06	5.101
HDACs deacetylate histones	R-HSA-3214815	9.643167e-06	5.016
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.010571e-05	4.995
Apoptotic execution phase	R-HSA-75153	1.053399e-05	4.977
Regulation of CDH1 Gene Transcription	R-HSA-9764560	1.045636e-05	4.981
RNA Polymerase I Promoter Opening	R-HSA-73728	1.315571e-05	4.881
mRNA 3'-end processing	R-HSA-72187	1.469823e-05	4.833
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.581801e-05	4.801
Mitotic Prophase	R-HSA-68875	1.679139e-05	4.775
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	1.898734e-05	4.722
Regulation of endogenous retroelements	R-HSA-9842860	2.016563e-05	4.695
Diseases of programmed cell death	R-HSA-9645723	2.072638e-05	4.683
Assembly of the ORC complex at the origin of replication	R-HSA-68616	2.356461e-05	4.628
ESR-mediated signaling	R-HSA-8939211	2.536222e-05	4.596
SIRT1 negatively regulates rRNA expression	R-HSA-427359	2.798786e-05	4.553
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	2.942038e-05	4.531
Processing of DNA double-strand break ends	R-HSA-5693607	3.302257e-05	4.481
RNA Polymerase II Transcription Termination	R-HSA-73856	3.708060e-05	4.431
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	3.957052e-05	4.403
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	4.230557e-05	4.374
DNA Double Strand Break Response	R-HSA-5693606	4.478795e-05	4.349
Packaging Of Telomere Ends	R-HSA-171306	5.234961e-05	4.281
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	5.243304e-05	4.280
Transcriptional regulation by RUNX1	R-HSA-8878171	5.640402e-05	4.249
Epigenetic regulation of gene expression	R-HSA-212165	5.648202e-05	4.248
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.216410e-05	4.206
Signaling by NTRK1 (TRKA)	R-HSA-187037	6.041727e-05	4.219
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.136439e-05	4.147
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	7.984120e-05	4.098
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	7.984120e-05	4.098
NoRC negatively regulates rRNA expression	R-HSA-427413	9.566371e-05	4.019
Signaling by NTRKs	R-HSA-166520	1.161805e-04	3.935
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.187590e-04	3.925
Signaling by ALK in cancer	R-HSA-9700206	1.187590e-04	3.925
RNA Polymerase I Transcription	R-HSA-73864	1.279027e-04	3.893
Apoptosis	R-HSA-109581	1.430296e-04	3.845
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.565722e-04	3.805
mTORC1-mediated signalling	R-HSA-166208	1.592330e-04	3.798
Meiosis	R-HSA-1500620	1.645237e-04	3.784
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.216107e-04	3.654
RNA Polymerase I Promoter Clearance	R-HSA-73854	2.276900e-04	3.643
PKMTs methylate histone lysines	R-HSA-3214841	2.487562e-04	3.604
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.514500e-04	3.600
Nucleosome assembly	R-HSA-774815	2.514500e-04	3.600
Cell-Cell communication	R-HSA-1500931	2.718016e-04	3.566
Regulation of MECP2 expression and activity	R-HSA-9022692	2.866863e-04	3.543
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.059411e-04	3.514
Homology Directed Repair	R-HSA-5693538	3.083404e-04	3.511
Cleavage of the damaged pyrimidine	R-HSA-110329	3.859804e-04	3.413
Depyrimidination	R-HSA-73928	3.859804e-04	3.413
Axon guidance	R-HSA-422475	4.268841e-04	3.370
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.503558e-04	3.346
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	5.053840e-04	3.296
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	5.585275e-04	3.253
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	5.886424e-04	3.230
EPH-Ephrin signaling	R-HSA-2682334	6.210000e-04	3.207
Nervous system development	R-HSA-9675108	6.654842e-04	3.177
DNA Double-Strand Break Repair	R-HSA-5693532	7.754345e-04	3.110
Meiotic recombination	R-HSA-912446	8.186649e-04	3.087
Vesicle-mediated transport	R-HSA-5653656	8.612094e-04	3.065
Programmed Cell Death	R-HSA-5357801	9.576077e-04	3.019
Cleavage of the damaged purine	R-HSA-110331	9.136659e-04	3.039
Semaphorin interactions	R-HSA-373755	9.904614e-04	3.004
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	1.060989e-03	2.974
Depurination	R-HSA-73927	1.125967e-03	2.948
TCF dependent signaling in response to WNT	R-HSA-201681	1.268962e-03	2.897
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.403759e-03	2.853
DNA Replication Pre-Initiation	R-HSA-69002	1.493698e-03	2.826
Assembly of the pre-replicative complex	R-HSA-68867	1.528413e-03	2.816
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	1.605919e-03	2.794
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	1.714771e-03	2.766
MITF-M-regulated melanocyte development	R-HSA-9730414	1.841210e-03	2.735
Activation of BAD and translocation to mitochondria	R-HSA-111447	2.110696e-03	2.676
MITF-M-dependent gene expression	R-HSA-9856651	1.997990e-03	2.699
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	2.110632e-03	2.676
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	2.129062e-03	2.672
EPHA-mediated growth cone collapse	R-HSA-3928663	2.175947e-03	2.662
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.216105e-03	2.654
Signaling by WNT	R-HSA-195721	2.256348e-03	2.647
Rab regulation of trafficking	R-HSA-9007101	2.262575e-03	2.645
Cell junction organization	R-HSA-446728	2.385655e-03	2.622
RNA Polymerase I Promoter Escape	R-HSA-73772	2.460348e-03	2.609
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.778493e-03	2.556
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	2.682355e-03	2.571
Mitotic Prometaphase	R-HSA-68877	2.915661e-03	2.535
NGF-stimulated transcription	R-HSA-9031628	3.165894e-03	2.500
RUNX3 regulates p14-ARF	R-HSA-8951936	3.188740e-03	2.496
ALK mutants bind TKIs	R-HSA-9700645	3.255170e-03	2.487
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	3.236828e-03	2.490
Chromosome Maintenance	R-HSA-73886	3.399435e-03	2.469
Signaling by ERBB2	R-HSA-1227986	3.504094e-03	2.455
TBC/RABGAPs	R-HSA-8854214	3.451133e-03	2.462
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.255170e-03	2.487
Cellular responses to stress	R-HSA-2262752	3.422058e-03	2.466
Base-Excision Repair, AP Site Formation	R-HSA-73929	3.363183e-03	2.473
Transcriptional regulation by small RNAs	R-HSA-5578749	3.645699e-03	2.438
Transcriptional Regulation by E2F6	R-HSA-8953750	3.725605e-03	2.429
Oncogenic MAPK signaling	R-HSA-6802957	4.108487e-03	2.386
Maternal to zygotic transition (MZT)	R-HSA-9816359	4.129251e-03	2.384
Sema4D in semaphorin signaling	R-HSA-400685	4.238953e-03	2.373
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.414651e-03	2.355
Mitotic G1 phase and G1/S transition	R-HSA-453279	4.492229e-03	2.348
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	4.553483e-03	2.342
Signaling by Hippo	R-HSA-2028269	5.044104e-03	2.297
Death Receptor Signaling	R-HSA-73887	5.044478e-03	2.297
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	5.007829e-03	2.300
Regulation of CDH1 Expression and Function	R-HSA-9764265	5.007829e-03	2.300
HSF1-dependent transactivation	R-HSA-3371571	5.047425e-03	2.297
Deubiquitination	R-HSA-5688426	5.183300e-03	2.285
Telomere Maintenance	R-HSA-157579	5.491773e-03	2.260
Signaling by Nuclear Receptors	R-HSA-9006931	5.581568e-03	2.253
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	5.607423e-03	2.251
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	5.607423e-03	2.251
Signaling downstream of RAS mutants	R-HSA-9649948	5.607423e-03	2.251
Signaling by RAS mutants	R-HSA-6802949	5.607423e-03	2.251
Clathrin-mediated endocytosis	R-HSA-8856828	6.107999e-03	2.214
Signaling by RAF1 mutants	R-HSA-9656223	6.192973e-03	2.208
Cellular response to heat stress	R-HSA-3371556	6.280565e-03	2.202
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	7.015213e-03	2.154
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	6.786290e-03	2.168
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	6.786290e-03	2.168
MTOR signalling	R-HSA-165159	7.256444e-03	2.139
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	7.357321e-03	2.133
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.728475e-03	2.112
Cellular responses to stimuli	R-HSA-8953897	7.850290e-03	2.105
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	7.893416e-03	2.103
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	8.206761e-03	2.086
Sensory processing of sound	R-HSA-9659379	8.507103e-03	2.070
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	8.692133e-03	2.061
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	8.692133e-03	2.061
Mitotic Telophase/Cytokinesis	R-HSA-68884	9.282628e-03	2.032
Signaling by EGFR	R-HSA-177929	1.011160e-02	1.995
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	9.667430e-03	2.015
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.011160e-02	1.995
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.011160e-02	1.995
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.028145e-02	1.988
Transcriptional regulation by RUNX3	R-HSA-8878159	1.045390e-02	1.981
Centrosome maturation	R-HSA-380287	1.090809e-02	1.962
Activation of BH3-only proteins	R-HSA-114452	1.135113e-02	1.945
Signaling by PTK6	R-HSA-8848021	1.137686e-02	1.944
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	1.137686e-02	1.944
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	1.177804e-02	1.929
Oncogene Induced Senescence	R-HSA-2559585	1.221926e-02	1.913
HDMs demethylate histones	R-HSA-3214842	1.222515e-02	1.913
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.241522e-02	1.906
Signaling by LTK	R-HSA-9842663	1.241522e-02	1.906
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.241522e-02	1.906
p75 NTR receptor-mediated signalling	R-HSA-193704	1.263866e-02	1.898
mRNA Splicing - Minor Pathway	R-HSA-72165	1.302518e-02	1.885
Disorders of Developmental Biology	R-HSA-9675151	1.306636e-02	1.884
Regulation of TP53 Activity	R-HSA-5633007	1.346947e-02	1.871
GP1b-IX-V activation signalling	R-HSA-430116	1.446075e-02	1.840
MAP2K and MAPK activation	R-HSA-5674135	1.473478e-02	1.832
G alpha (12/13) signalling events	R-HSA-416482	1.504878e-02	1.822
SARS-CoV-1-host interactions	R-HSA-9692914	1.439386e-02	1.842
Base Excision Repair	R-HSA-73884	1.526935e-02	1.816
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.438129e-02	1.842
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	1.553847e-02	1.809
Listeria monocytogenes entry into host cells	R-HSA-8876384	1.576363e-02	1.802
Reproduction	R-HSA-1474165	1.587268e-02	1.799
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	1.622405e-02	1.790
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	1.622405e-02	1.790
Regulation of PTEN gene transcription	R-HSA-8943724	1.651917e-02	1.782
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.687030e-02	1.773
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.687030e-02	1.773
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.687030e-02	1.773
Adherens junctions interactions	R-HSA-418990	1.725162e-02	1.763
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.734319e-02	1.761
Activation of ATR in response to replication stress	R-HSA-176187	1.864218e-02	1.730
Notch-HLH transcription pathway	R-HSA-350054	1.909600e-02	1.719
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.970993e-02	1.705
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	2.172584e-02	1.663
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.172584e-02	1.663
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	2.308775e-02	1.637
Loss of Nlp from mitotic centrosomes	R-HSA-380259	2.308775e-02	1.637
EPHB-mediated forward signaling	R-HSA-3928662	2.208961e-02	1.656
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	2.143641e-02	1.669
Activation of HOX genes during differentiation	R-HSA-5619507	2.143641e-02	1.669
DNA Replication	R-HSA-69306	2.169730e-02	1.664
Metabolism of RNA	R-HSA-8953854	2.138090e-02	1.670
Cell-cell junction organization	R-HSA-421270	2.179244e-02	1.662
Regulation of KIT signaling	R-HSA-1433559	2.077082e-02	1.683
Amyloid fiber formation	R-HSA-977225	2.032664e-02	1.692
NRAGE signals death through JNK	R-HSA-193648	2.132830e-02	1.671
Interleukin-12 signaling	R-HSA-9020591	2.348373e-02	1.629
Diseases of Telomere Maintenance	R-HSA-9673013	2.351857e-02	1.629
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.351857e-02	1.629
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.351857e-02	1.629
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.351857e-02	1.629
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.351857e-02	1.629
Loss of MECP2 binding ability to 5hmC-DNA	R-HSA-9022534	2.351857e-02	1.629
RAF activation	R-HSA-5673000	2.511526e-02	1.600
Nuclear signaling by ERBB4	R-HSA-1251985	2.528077e-02	1.597
Attenuation phase	R-HSA-3371568	2.528077e-02	1.597
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.565598e-02	1.591
Regulation of localization of FOXO transcription factors	R-HSA-9614399	2.592703e-02	1.586
PECAM1 interactions	R-HSA-210990	2.592703e-02	1.586
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.611062e-02	1.583
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	2.611062e-02	1.583
Cell-extracellular matrix interactions	R-HSA-446353	2.611062e-02	1.583
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.692072e-02	1.570
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	2.721376e-02	1.565
MECP2 regulates transcription factors	R-HSA-9022707	3.132989e-02	1.504
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	R-HSA-9031528	3.132989e-02	1.504
Cohesin Loading onto Chromatin	R-HSA-2470946	3.132989e-02	1.504
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	3.132989e-02	1.504
Activation of the pre-replicative complex	R-HSA-68962	2.845258e-02	1.546
AURKA Activation by TPX2	R-HSA-8854518	3.144576e-02	1.502
Nuclear Receptor transcription pathway	R-HSA-383280	2.840906e-02	1.547
SWI/SNF chromatin remodelers	R-HSA-9932451	3.205703e-02	1.494
ATP-dependent chromatin remodelers	R-HSA-9932444	3.205703e-02	1.494
TGFBR3 expression	R-HSA-9839394	3.205703e-02	1.494
Signalling to ERKs	R-HSA-187687	2.889530e-02	1.539
Long-term potentiation	R-HSA-9620244	3.205703e-02	1.494
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.757603e-02	1.559
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.147134e-02	1.502
Gene expression (Transcription)	R-HSA-74160	2.950614e-02	1.530
Signaling by TGFBR3	R-HSA-9839373	2.831029e-02	1.548
Transcriptional Regulation by VENTX	R-HSA-8853884	2.879036e-02	1.541
Prolonged ERK activation events	R-HSA-169893	3.229083e-02	1.491
EGFR downregulation	R-HSA-182971	3.295654e-02	1.482
G1/S-Specific Transcription	R-HSA-69205	3.306203e-02	1.481
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	3.335868e-02	1.477
Regulation of gap junction activity	R-HSA-191650	3.449011e-02	1.462
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	3.449011e-02	1.462
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	3.745735e-02	1.426
Diseases of mitotic cell cycle	R-HSA-9675126	3.793071e-02	1.421
Interleukin-12 family signaling	R-HSA-447115	3.806229e-02	1.420
Signaling by NOTCH	R-HSA-157118	3.810461e-02	1.419
GRB2 events in ERBB2 signaling	R-HSA-1963640	3.935024e-02	1.405
RNA Polymerase II Transcription	R-HSA-73857	4.120842e-02	1.385
Downregulation of ERBB4 signaling	R-HSA-1253288	4.194956e-02	1.377
Signaling by MRAS-complex mutants	R-HSA-9660537	4.194956e-02	1.377
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	4.194956e-02	1.377
Pervasive developmental disorders	R-HSA-9005895	4.199010e-02	1.377
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	4.199010e-02	1.377
Disorders of Nervous System Development	R-HSA-9697154	4.199010e-02	1.377
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	4.232175e-02	1.373
Gene Silencing by RNA	R-HSA-211000	4.572276e-02	1.340
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	4.632788e-02	1.334
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	4.839116e-02	1.315
Breakdown of the nuclear lamina	R-HSA-352238	4.903883e-02	1.309
FGFR2 alternative splicing	R-HSA-6803529	4.957266e-02	1.305
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	5.034503e-02	1.298
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.034503e-02	1.298
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	5.184933e-02	1.285
ARMS-mediated activation	R-HSA-170984	5.435919e-02	1.265
Calcineurin activates NFAT	R-HSA-2025928	5.435919e-02	1.265
Signaling by ERBB2 KD Mutants	R-HSA-9664565	5.720030e-02	1.243
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	5.720030e-02	1.243
Formation of RNA Pol II elongation complex	R-HSA-112382	5.442148e-02	1.264
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.997015e-02	1.222
Amplification of signal from the kinetochores	R-HSA-141424	5.594614e-02	1.252
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	5.594614e-02	1.252
Intracellular signaling by second messengers	R-HSA-9006925	6.252521e-02	1.204
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	5.435919e-02	1.265
Unwinding of DNA	R-HSA-176974	5.435919e-02	1.265
Depolymerization of the Nuclear Lamina	R-HSA-4419969	5.621587e-02	1.250
MHC class II antigen presentation	R-HSA-2132295	5.913246e-02	1.228
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	5.756469e-02	1.240
Nephron development	R-HSA-9831926	5.621587e-02	1.250
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	5.621587e-02	1.250
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	6.294668e-02	1.201
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.294668e-02	1.201
Transcriptional Regulation by TP53	R-HSA-3700989	6.332934e-02	1.198
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	6.349124e-02	1.197
RNA Polymerase II Pre-transcription Events	R-HSA-674695	6.418188e-02	1.193
Signaling by ERBB2 in Cancer	R-HSA-1227990	6.501046e-02	1.187
Deadenylation of mRNA	R-HSA-429947	6.630870e-02	1.178
G2/M Transition	R-HSA-69275	6.713927e-02	1.173
PLC beta mediated events	R-HSA-112043	6.758547e-02	1.170
PI3K/AKT activation	R-HSA-198203	6.853461e-02	1.164
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	6.853461e-02	1.164
Signal attenuation	R-HSA-74749	6.853461e-02	1.164
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	6.853461e-02	1.164
Signalling to p38 via RIT and RIN	R-HSA-187706	6.912033e-02	1.160
Noncanonical activation of NOTCH3	R-HSA-9017802	6.912033e-02	1.160
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.912033e-02	1.160
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.912033e-02	1.160
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.912033e-02	1.160
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	6.991832e-02	1.155
HSF1 activation	R-HSA-3371511	7.039649e-02	1.152
Calmodulin induced events	R-HSA-111933	7.039649e-02	1.152
CaM pathway	R-HSA-111997	7.039649e-02	1.152
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	8.085525e-02	1.092
Diseases of cellular response to stress	R-HSA-9675132	8.085525e-02	1.092
Diseases of Cellular Senescence	R-HSA-9630747	8.085525e-02	1.092
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	8.085525e-02	1.092
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	8.085525e-02	1.092
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	8.085525e-02	1.092
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	8.085525e-02	1.092
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	8.085525e-02	1.092
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	8.085525e-02	1.092
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	8.085525e-02	1.092
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	8.085525e-02	1.092
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	8.085525e-02	1.092
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	8.085525e-02	1.092
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	8.085525e-02	1.092
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	8.441854e-02	1.074
Erythropoietin activates RAS	R-HSA-9027284	7.527538e-02	1.123
Sema3A PAK dependent Axon repulsion	R-HSA-399954	7.527538e-02	1.123
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.881279e-02	1.052
TNFR1-induced proapoptotic signaling	R-HSA-5357786	8.854158e-02	1.053
Transport of the SLBP independent Mature mRNA	R-HSA-159227	9.222384e-02	1.035
G0 and Early G1	R-HSA-1538133	8.252137e-02	1.083
G1 Phase	R-HSA-69236	9.017376e-02	1.045
Cyclin D associated events in G1	R-HSA-69231	9.017376e-02	1.045
Integrin signaling	R-HSA-354192	9.222384e-02	1.035
Nephrin family interactions	R-HSA-373753	7.683086e-02	1.114
DCC mediated attractive signaling	R-HSA-418885	7.527538e-02	1.123
Ca-dependent events	R-HSA-111996	7.425727e-02	1.129
Extra-nuclear estrogen signaling	R-HSA-9009391	7.418790e-02	1.130
Co-inhibition by PD-1	R-HSA-389948	9.074744e-02	1.042
Signaling by NOTCH1	R-HSA-1980143	7.502654e-02	1.125
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	8.085525e-02	1.092
Mitotic G2-G2/M phases	R-HSA-453274	7.393689e-02	1.131
L1CAM interactions	R-HSA-373760	9.225853e-02	1.035
Negative regulation of MET activity	R-HSA-6807004	7.683086e-02	1.114
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	8.700667e-02	1.060
SARS-CoV-1 Infection	R-HSA-9678108	8.102578e-02	1.091
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	9.279220e-02	1.032
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	9.627508e-02	1.016
Signaling by ALK	R-HSA-201556	9.627508e-02	1.016
Interaction between L1 and Ankyrins	R-HSA-445095	9.707309e-02	1.013
DAG and IP3 signaling	R-HSA-1489509	9.884198e-02	1.005
Deadenylation-dependent mRNA decay	R-HSA-429914	1.010403e-01	0.996
Activated NTRK2 signals through RAS	R-HSA-9026519	1.019258e-01	0.992
Signaling by AMER1 mutants	R-HSA-4839748	1.019258e-01	0.992
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.019258e-01	0.992
Striated Muscle Contraction	R-HSA-390522	1.025522e-01	0.989
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	1.025522e-01	0.989
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.035217e-01	0.985
SHC1 events in ERBB4 signaling	R-HSA-1250347	1.035217e-01	0.985
Acetylcholine regulates insulin secretion	R-HSA-399997	1.035217e-01	0.985
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.059798e-01	0.975
G1/S Transition	R-HSA-69206	1.066463e-01	0.972
Regulation of TNFR1 signaling	R-HSA-5357905	1.079807e-01	0.967
Signaling by ERBB4	R-HSA-1236394	1.081704e-01	0.966
G-protein mediated events	R-HSA-112040	1.088921e-01	0.963
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.089629e-01	0.963
Mitotic Spindle Checkpoint	R-HSA-69618	1.091774e-01	0.962
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	1.092024e-01	0.962
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	1.092024e-01	0.962
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	1.092024e-01	0.962
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	1.092024e-01	0.962
Kinesins	R-HSA-983189	1.092024e-01	0.962
Signaling by NOTCH1 in Cancer	R-HSA-2644603	1.092024e-01	0.962
Drug resistance of PDGFR mutants	R-HSA-9674415	1.105809e-01	0.956
PDGFR mutants bind TKIs	R-HSA-9674428	1.105809e-01	0.956
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.105809e-01	0.956
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.105809e-01	0.956
Evasion of Oncogene Induced Senescence Due to p14ARF Defects	R-HSA-9646303	1.105809e-01	0.956
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.105809e-01	0.956
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects	R-HSA-9646304	1.105809e-01	0.956
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	1.105809e-01	0.956
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.105809e-01	0.956
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.105809e-01	0.956
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.105809e-01	0.956
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	1.134975e-01	0.945
Mitophagy	R-HSA-5205647	1.134975e-01	0.945
Activation of TRKA receptors	R-HSA-187015	1.144076e-01	0.942
RUNX3 regulates WNT signaling	R-HSA-8951430	1.144076e-01	0.942
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	1.144076e-01	0.942
SOS-mediated signalling	R-HSA-112412	1.144076e-01	0.942
Uptake and function of diphtheria toxin	R-HSA-5336415	1.144076e-01	0.942
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	1.146859e-01	0.940
DNA Repair	R-HSA-73894	1.151832e-01	0.939
Protein ubiquitination	R-HSA-8852135	1.158366e-01	0.936
TRKA activation by NGF	R-HSA-187042	1.172648e-01	0.931
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	1.172648e-01	0.931
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	1.172648e-01	0.931
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.172648e-01	0.931
MECP2 regulates transcription of genes involved in GABA signaling	R-HSA-9022927	1.568636e-01	0.804
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.568636e-01	0.804
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.568636e-01	0.804
Drug-mediated inhibition of CDK4/CDK6 activity	R-HSA-9754119	1.568636e-01	0.804
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	1.568636e-01	0.804
Type I hemidesmosome assembly	R-HSA-446107	1.403096e-01	0.853
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	1.403096e-01	0.853
Formation of annular gap junctions	R-HSA-196025	1.403096e-01	0.853
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.209484e-01	0.917
SHC-related events triggered by IGF1R	R-HSA-2428933	1.209484e-01	0.917
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	1.413605e-01	0.850
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	1.413605e-01	0.850
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.193519e-01	0.923
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.193519e-01	0.923
PI3K events in ERBB2 signaling	R-HSA-1963642	1.193519e-01	0.923
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.362419e-01	0.866
GAB1 signalosome	R-HSA-180292	1.362419e-01	0.866
G beta:gamma signalling through PLC beta	R-HSA-418217	1.362419e-01	0.866
Regulation of signaling by CBL	R-HSA-912631	1.541207e-01	0.812
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.541207e-01	0.812
Termination of translesion DNA synthesis	R-HSA-5656169	1.212798e-01	0.916
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	1.344402e-01	0.871
Transcriptional Regulation by MECP2	R-HSA-8986944	1.352339e-01	0.869
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.362419e-01	0.866
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	1.225326e-01	0.912
Interleukin-6 signaling	R-HSA-1059683	1.413605e-01	0.850
Polo-like kinase mediated events	R-HSA-156711	1.362419e-01	0.866
Frs2-mediated activation	R-HSA-170968	1.413605e-01	0.850
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	1.382385e-01	0.859
Chaperone Mediated Autophagy	R-HSA-9613829	1.362419e-01	0.866
VLDLR internalisation and degradation	R-HSA-8866427	1.209484e-01	0.917
TNF signaling	R-HSA-75893	1.373105e-01	0.862
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.381620e-01	0.860
Mitotic Anaphase	R-HSA-68882	1.326506e-01	0.877
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.376917e-01	0.861
trans-Golgi Network Vesicle Budding	R-HSA-199992	1.526281e-01	0.816
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.210391e-01	0.917
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.526281e-01	0.816
Rap1 signalling	R-HSA-392517	1.541207e-01	0.812
Downregulation of ERBB2 signaling	R-HSA-8863795	1.344402e-01	0.871
Ovarian tumor domain proteases	R-HSA-5689896	1.498918e-01	0.824
Regulation of T cell activation by CD28 family	R-HSA-388841	1.382344e-01	0.859
Presynaptic function of Kainate receptors	R-HSA-500657	1.362419e-01	0.866
RET signaling	R-HSA-8853659	1.371852e-01	0.863
MAPK1/MAPK3 signaling	R-HSA-5684996	1.420536e-01	0.848
Nuclear Envelope Breakdown	R-HSA-2980766	1.475599e-01	0.831
Developmental Biology	R-HSA-1266738	1.325568e-01	0.878
Signaling by ROBO receptors	R-HSA-376176	1.401951e-01	0.853
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.413605e-01	0.850
Golgi-to-ER retrograde transport	R-HSA-8856688	1.574890e-01	0.803
MAPK family signaling cascades	R-HSA-5683057	1.580495e-01	0.801
Signaling by MET	R-HSA-6806834	1.587535e-01	0.799
Interleukin-7 signaling	R-HSA-1266695	1.602251e-01	0.795
RMTs methylate histone arginines	R-HSA-3214858	1.622400e-01	0.790
DNA strand elongation	R-HSA-69190	1.627396e-01	0.789
Retrograde neurotrophin signalling	R-HSA-177504	1.630232e-01	0.788
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	1.630232e-01	0.788
Signal regulatory protein family interactions	R-HSA-391160	1.630232e-01	0.788
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	1.672512e-01	0.777
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.679483e-01	0.775
Gap junction degradation	R-HSA-190873	1.679483e-01	0.775
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	1.679483e-01	0.775
MAPK1 (ERK2) activation	R-HSA-112411	1.679483e-01	0.775
Neurexins and neuroligins	R-HSA-6794361	1.722840e-01	0.764
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	1.729094e-01	0.762
VxPx cargo-targeting to cilium	R-HSA-5620916	1.729094e-01	0.762
Selective autophagy	R-HSA-9663891	1.733105e-01	0.761
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.749394e-01	0.757
PIP3 activates AKT signaling	R-HSA-1257604	1.753636e-01	0.756
S Phase	R-HSA-69242	1.763225e-01	0.754
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	1.769160e-01	0.752
Myogenesis	R-HSA-525793	1.769160e-01	0.752
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	1.769183e-01	0.752
G-protein beta:gamma signalling	R-HSA-397795	1.778124e-01	0.750
Autophagy	R-HSA-9612973	1.781582e-01	0.749
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.850245e-01	0.733
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	1.857886e-01	0.731
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	1.857886e-01	0.731
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.857886e-01	0.731
Spry regulation of FGF signaling	R-HSA-1295596	1.857886e-01	0.731
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	R-HSA-9645722	2.089395e-01	0.680
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.089395e-01	0.680
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9632697	2.089395e-01	0.680
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4	R-HSA-9630791	2.089395e-01	0.680
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.089395e-01	0.680
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.089395e-01	0.680
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	R-HSA-9630750	2.964260e-01	0.528
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	R-HSA-9632693	2.964260e-01	0.528
Defective SLC26A2 causes chondrodysplasias	R-HSA-3560792	2.964260e-01	0.528
Signaling by TCF7L2 mutants	R-HSA-5339700	2.964260e-01	0.528
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.964260e-01	0.528
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.964260e-01	0.528
Defective MMADHC causes MMAHCD	R-HSA-3359473	2.964260e-01	0.528
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.964260e-01	0.528
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	2.964260e-01	0.528
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	2.964260e-01	0.528
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9630794	2.964260e-01	0.528
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6	R-HSA-9632700	2.964260e-01	0.528
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	2.964260e-01	0.528
IRS activation	R-HSA-74713	1.985021e-01	0.702
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.985021e-01	0.702
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.985021e-01	0.702
NGF-independant TRKA activation	R-HSA-187024	2.412456e-01	0.618
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.412456e-01	0.618
NTF4 activates NTRK2 (TRKB) signaling	R-HSA-9026357	3.742415e-01	0.427
BDNF activates NTRK2 (TRKB) signaling	R-HSA-9024909	3.742415e-01	0.427
NTF3 activates NTRK2 (TRKB) signaling	R-HSA-9025046	3.742415e-01	0.427
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.742415e-01	0.427
Glycogen storage disease type IV (GBE1)	R-HSA-3878781	3.742415e-01	0.427
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	3.742415e-01	0.427
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.742415e-01	0.427
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.742415e-01	0.427
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	3.742415e-01	0.427
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.969960e-01	0.706
Receptor Mediated Mitophagy	R-HSA-8934903	1.969960e-01	0.706
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	1.969960e-01	0.706
Erythropoietin activates STAT5	R-HSA-9027283	2.843409e-01	0.546
Autointegration results in viral DNA circles	R-HSA-177539	2.843409e-01	0.546
Activated NTRK3 signals through RAS	R-HSA-9034864	2.271346e-01	0.644
Signaling by APC mutants	R-HSA-4839744	2.271346e-01	0.644
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.271346e-01	0.644
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.271346e-01	0.644
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.271346e-01	0.644
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	2.095035e-01	0.679
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.095035e-01	0.679
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	2.580627e-01	0.588
Condensation of Prometaphase Chromosomes	R-HSA-2514853	2.580627e-01	0.588
Signaling by GSK3beta mutants	R-HSA-5339716	2.580627e-01	0.588
IFNG signaling activates MAPKs	R-HSA-9732724	3.271880e-01	0.485
TRIF-mediated programmed cell death	R-HSA-2562578	3.271880e-01	0.485
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	R-HSA-9031525	3.271880e-01	0.485
PLC-gamma1 signalling	R-HSA-167021	4.434547e-01	0.353
Axonal growth stimulation	R-HSA-209563	4.434547e-01	0.353
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.434547e-01	0.353
Defective MMACHC causes MAHCC	R-HSA-3359474	4.434547e-01	0.353
Defective DPM2 causes DPM2-CDG	R-HSA-4719377	4.434547e-01	0.353
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	4.434547e-01	0.353
MET activates PTPN11	R-HSA-8865999	4.434547e-01	0.353
Invadopodia formation	R-HSA-8941237	4.434547e-01	0.353
Defective DPM3 causes DPM3-CDG	R-HSA-4719360	4.434547e-01	0.353
Defective DPM1 causes DPM1-CDG	R-HSA-4717374	4.434547e-01	0.353
Signalling to STAT3	R-HSA-198745	4.434547e-01	0.353
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.925230e-01	0.716
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.925230e-01	0.716
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.340132e-01	0.631
Polymerase switching	R-HSA-69091	2.894996e-01	0.538
Leading Strand Synthesis	R-HSA-69109	2.894996e-01	0.538
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.894996e-01	0.538
Scavenging by Class F Receptors	R-HSA-3000484	2.894996e-01	0.538
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.894996e-01	0.538
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.894996e-01	0.538
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.894996e-01	0.538
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.894996e-01	0.538
Signaling by PDGFR in disease	R-HSA-9671555	2.128718e-01	0.672
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	2.591637e-01	0.586
Activated NTRK2 signals through FYN	R-HSA-9032500	3.693150e-01	0.433
Regulation by c-FLIP	R-HSA-3371378	3.693150e-01	0.433
Dimerization of procaspase-8	R-HSA-69416	3.693150e-01	0.433
MET receptor recycling	R-HSA-8875656	3.693150e-01	0.433
Regulation of NPAS4 mRNA translation	R-HSA-9768778	3.693150e-01	0.433
Activated NTRK2 signals through PI3K	R-HSA-9028335	3.693150e-01	0.433
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	2.307567e-01	0.637
Late endosomal microautophagy	R-HSA-9615710	2.307567e-01	0.637
TRAF6 mediated NF-kB activation	R-HSA-933542	2.773981e-01	0.557
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	3.528947e-01	0.452
CRMPs in Sema3A signaling	R-HSA-399956	3.528947e-01	0.452
WNT mediated activation of DVL	R-HSA-201688	4.103572e-01	0.387
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	4.103572e-01	0.387
CASP8 activity is inhibited	R-HSA-5218900	4.103572e-01	0.387
Activated NTRK2 signals through PLCG1	R-HSA-9026527	5.050160e-01	0.297
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	5.050160e-01	0.297
Inhibition of TSC complex formation by PKB	R-HSA-165181	5.050160e-01	0.297
GRB7 events in ERBB2 signaling	R-HSA-1306955	5.050160e-01	0.297
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.050160e-01	0.297
Recycling pathway of L1	R-HSA-437239	2.016302e-01	0.695
Translation initiation complex formation	R-HSA-72649	1.970343e-01	0.705
Polymerase switching on the C-strand of the telomere	R-HSA-174411	2.997532e-01	0.523
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	3.369828e-01	0.472
Co-inhibition by CTLA4	R-HSA-389513	3.369828e-01	0.472
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.369828e-01	0.472
IRF3-mediated induction of type I IFN	R-HSA-3270619	3.844134e-01	0.415
Beta-catenin phosphorylation cascade	R-HSA-196299	3.844134e-01	0.415
SHC1 events in EGFR signaling	R-HSA-180336	3.844134e-01	0.415
Signaling by EGFR in Cancer	R-HSA-1643713	3.223770e-01	0.492
MET activates RAP1 and RAC1	R-HSA-8875555	4.500395e-01	0.347
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.500395e-01	0.347
DNA replication initiation	R-HSA-68952	4.500395e-01	0.347
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	2.506676e-01	0.601
Signaling by NTRK2 (TRKB)	R-HSA-9006115	3.451805e-01	0.462
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	3.451805e-01	0.462
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	3.451805e-01	0.462
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	3.451805e-01	0.462
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.343527e-01	0.630
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.292915e-01	0.482
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	3.150463e-01	0.502
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	3.894759e-01	0.410
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	3.894759e-01	0.410
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	3.894759e-01	0.410
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	3.894759e-01	0.410
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.680782e-01	0.434
HIV elongation arrest and recovery	R-HSA-167287	3.680782e-01	0.434
Formation of the Early Elongation Complex	R-HSA-113418	3.680782e-01	0.434
Pausing and recovery of HIV elongation	R-HSA-167290	3.680782e-01	0.434
Signaling by Erythropoietin	R-HSA-9006335	3.909882e-01	0.408
G beta:gamma signalling through CDC42	R-HSA-8964616	4.461823e-01	0.350
Processing of Intronless Pre-mRNAs	R-HSA-77595	4.461823e-01	0.350
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	4.881607e-01	0.311
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.597710e-01	0.252
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.597710e-01	0.252
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.597710e-01	0.252
NTRK2 activates RAC1	R-HSA-9032759	5.597710e-01	0.252
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.597710e-01	0.252
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.597710e-01	0.252
Defective F9 activation	R-HSA-9673221	5.597710e-01	0.252
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.597710e-01	0.252
FLT3 signaling by CBL mutants	R-HSA-9706377	5.597710e-01	0.252
Ribosomal scanning and start codon recognition	R-HSA-72702	3.378574e-01	0.471
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	3.908693e-01	0.408
Interleukin receptor SHC signaling	R-HSA-912526	4.413521e-01	0.355
Separation of Sister Chromatids	R-HSA-2467813	2.389301e-01	0.622
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	3.703141e-01	0.431
Vpr-mediated nuclear import of PICs	R-HSA-180910	4.114378e-01	0.386
snRNP Assembly	R-HSA-191859	3.866581e-01	0.413
Metabolism of non-coding RNA	R-HSA-194441	3.866581e-01	0.413
Orc1 removal from chromatin	R-HSA-68949	4.059118e-01	0.392
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	4.668105e-01	0.331
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	5.245807e-01	0.280
PI3K events in ERBB4 signaling	R-HSA-1250342	5.245807e-01	0.280
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	5.245807e-01	0.280
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	4.001684e-01	0.398
Ephrin signaling	R-HSA-3928664	5.053238e-01	0.296
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	5.053238e-01	0.296
RNA Polymerase III Transcription Termination	R-HSA-73980	5.053238e-01	0.296
HCMV Early Events	R-HSA-9609690	3.128037e-01	0.505
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	4.120135e-01	0.385
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.837721e-01	0.416
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.837721e-01	0.416
Tight junction interactions	R-HSA-420029	4.918364e-01	0.308
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.051684e-01	0.392
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	5.163579e-01	0.287
E2F mediated regulation of DNA replication	R-HSA-113510	5.336397e-01	0.273
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.592094e-01	0.252
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.592094e-01	0.252
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	5.592094e-01	0.252
Repression of WNT target genes	R-HSA-4641265	5.592094e-01	0.252
GRB2 events in EGFR signaling	R-HSA-179812	5.592094e-01	0.252
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	5.316601e-01	0.274
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	5.425257e-01	0.266
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.562132e-01	0.255
Cap-dependent Translation Initiation	R-HSA-72737	5.586014e-01	0.253
Transcription of the HIV genome	R-HSA-167172	4.001684e-01	0.398
RNA Polymerase III Transcription	R-HSA-74158	3.908693e-01	0.408
Eukaryotic Translation Initiation	R-HSA-72613	5.586014e-01	0.253
Downstream signal transduction	R-HSA-186763	4.365423e-01	0.360
HIV Transcription Elongation	R-HSA-167169	3.150463e-01	0.502
Formation of definitive endoderm	R-HSA-9823730	3.369828e-01	0.472
RNA Polymerase III Transcription Initiation	R-HSA-76046	4.138337e-01	0.383
MET promotes cell motility	R-HSA-8875878	4.319349e-01	0.365
Switching of origins to a post-replicative state	R-HSA-69052	4.772733e-01	0.321
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	5.139767e-01	0.289
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	3.335833e-01	0.477
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	3.223770e-01	0.492
DNA Damage Bypass	R-HSA-73893	3.535567e-01	0.452
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	3.150463e-01	0.502
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.556456e-01	0.592
Aggrephagy	R-HSA-9646399	3.150463e-01	0.502
Nuclear import of Rev protein	R-HSA-180746	3.497378e-01	0.456
Synthesis of DNA	R-HSA-69239	5.300627e-01	0.276
EGFR Transactivation by Gastrin	R-HSA-2179392	1.969960e-01	0.706
Metalloprotease DUBs	R-HSA-5689901	3.223770e-01	0.492
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	4.668105e-01	0.331
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.340132e-01	0.631
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	4.155433e-01	0.381
WNT5A-dependent internalization of FZD4	R-HSA-5099900	2.095035e-01	0.679
Activated NTRK3 signals through PI3K	R-HSA-9603381	3.271880e-01	0.485
MET activates RAS signaling	R-HSA-8851805	2.894996e-01	0.538
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	3.693150e-01	0.433
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	3.693150e-01	0.433
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	2.967044e-01	0.528
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	4.155433e-01	0.381
LGI-ADAM interactions	R-HSA-5682910	4.881607e-01	0.311
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	4.881607e-01	0.311
Interleukin-6 family signaling	R-HSA-6783589	4.668105e-01	0.331
Regulation of RUNX3 expression and activity	R-HSA-8941858	3.150463e-01	0.502
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	2.691735e-01	0.570
CLEC7A/inflammasome pathway	R-HSA-5660668	2.412456e-01	0.618
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.340132e-01	0.631
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	2.128718e-01	0.672
p75NTR regulates axonogenesis	R-HSA-193697	4.103572e-01	0.387
Trafficking of AMPA receptors	R-HSA-399719	2.691735e-01	0.570
Signaling by WNT in cancer	R-HSA-4791275	2.889455e-01	0.539
DARPP-32 events	R-HSA-180024	3.909882e-01	0.408
ISG15 antiviral mechanism	R-HSA-1169408	3.826599e-01	0.417
PKA activation	R-HSA-163615	5.053238e-01	0.296
PCP/CE pathway	R-HSA-4086400	4.267123e-01	0.370
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	5.592094e-01	0.252
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.592094e-01	0.252
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	5.425257e-01	0.266
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.458747e-01	0.263
Signaling by NOTCH3	R-HSA-9012852	3.218051e-01	0.492
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	5.053238e-01	0.296
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.843409e-01	0.546
RUNX3 regulates NOTCH signaling	R-HSA-8941856	2.894996e-01	0.538
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.451805e-01	0.462
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	4.668105e-01	0.331
Integration of provirus	R-HSA-162592	5.245807e-01	0.280
HDR through Homologous Recombination (HRR)	R-HSA-5685942	5.164516e-01	0.287
GPER1 signaling	R-HSA-9634597	2.155743e-01	0.666
Signalling to RAS	R-HSA-167044	3.632518e-01	0.440
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	4.500395e-01	0.347
Late Phase of HIV Life Cycle	R-HSA-162599	4.164459e-01	0.380
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.988489e-01	0.302
Beta-catenin independent WNT signaling	R-HSA-3858494	2.628531e-01	0.580
HCMV Infection	R-HSA-9609646	4.984074e-01	0.302
Nuclear events mediated by NFE2L2	R-HSA-9759194	3.234627e-01	0.490
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.412456e-01	0.618
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	3.271880e-01	0.485
PTK6 Expression	R-HSA-8849473	3.271880e-01	0.485
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	2.340132e-01	0.631
Axonal growth inhibition (RHOA activation)	R-HSA-193634	3.693150e-01	0.433
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	3.693150e-01	0.433
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	3.107903e-01	0.508
RNA Polymerase I Transcription Initiation	R-HSA-73762	2.366292e-01	0.626
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.597710e-01	0.252
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.597710e-01	0.252
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.597710e-01	0.252
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	5.245807e-01	0.280
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	4.361559e-01	0.360
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	5.592094e-01	0.252
CLEC7A (Dectin-1) signaling	R-HSA-5607764	4.855937e-01	0.314
Circadian clock	R-HSA-9909396	4.691267e-01	0.329
Ca2+ pathway	R-HSA-4086398	2.467342e-01	0.608
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.635864e-01	0.579
Cilium Assembly	R-HSA-5617833	4.064288e-01	0.391
Signaling by SCF-KIT	R-HSA-1433557	2.525463e-01	0.598
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.412456e-01	0.618
Aryl hydrocarbon receptor signalling	R-HSA-8937144	2.412456e-01	0.618
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	2.580627e-01	0.588
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.050160e-01	0.297
Nuclear RNA decay	R-HSA-9930044	3.090063e-01	0.510
HIV Life Cycle	R-HSA-162587	3.186413e-01	0.497
Signaling by FGFR2	R-HSA-5654738	2.384447e-01	0.623
COPI-mediated anterograde transport	R-HSA-6807878	4.855937e-01	0.314
VEGFA-VEGFR2 Pathway	R-HSA-4420097	1.880197e-01	0.726
Signaling by TGFB family members	R-HSA-9006936	3.473577e-01	0.459
ROBO receptors bind AKAP5	R-HSA-9010642	3.693150e-01	0.433
PTEN Regulation	R-HSA-6807070	3.738218e-01	0.427
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	5.032035e-01	0.298
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	5.458747e-01	0.263
HIV Infection	R-HSA-162906	4.466764e-01	0.350
Interactions of Rev with host cellular proteins	R-HSA-177243	3.150463e-01	0.502
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	3.680782e-01	0.434
Signaling by FGFR4	R-HSA-5654743	5.507623e-01	0.259
Opioid Signalling	R-HSA-111885	1.998302e-01	0.699
Interleukin-27 signaling	R-HSA-9020956	4.500395e-01	0.347
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.413521e-01	0.355
Regulation of NPAS4 gene expression	R-HSA-9768759	2.591637e-01	0.586
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	3.844134e-01	0.415
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	2.782513e-01	0.556
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.812862e-01	0.318
Signaling by NOTCH2	R-HSA-1980145	5.247482e-01	0.280
PERK regulates gene expression	R-HSA-381042	5.458747e-01	0.263
Macroautophagy	R-HSA-1632852	2.366418e-01	0.626
Signaling by FGFR1	R-HSA-5654736	4.754663e-01	0.323
Generic Transcription Pathway	R-HSA-212436	2.611560e-01	0.583
Post NMDA receptor activation events	R-HSA-438064	2.418183e-01	0.617
Apoptotic factor-mediated response	R-HSA-111471	5.053238e-01	0.296
Signaling by VEGF	R-HSA-194138	2.915167e-01	0.535
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	4.275560e-01	0.369
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	4.834097e-01	0.316
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	5.507623e-01	0.259
FGFR1 mutant receptor activation	R-HSA-1839124	4.812862e-01	0.318
Signaling by FGFR	R-HSA-190236	3.014902e-01	0.521
Transport of connexins along the secretory pathway	R-HSA-190827	2.964260e-01	0.528
Manipulation of host energy metabolism	R-HSA-9636667	2.964260e-01	0.528
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.964260e-01	0.528
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.964260e-01	0.528
Nectin/Necl trans heterodimerization	R-HSA-420597	1.985021e-01	0.702
Signaling by AXIN mutants	R-HSA-4839735	2.580627e-01	0.588
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	3.271880e-01	0.485
MET interacts with TNS proteins	R-HSA-8875513	4.434547e-01	0.353
Platelet Adhesion to exposed collagen	R-HSA-75892	3.211877e-01	0.493
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.848045e-01	0.545
Signaling by FGFR2 IIIa TM	R-HSA-8851708	3.107903e-01	0.508
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	5.050160e-01	0.297
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	3.844134e-01	0.415
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	4.500395e-01	0.347
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	3.292915e-01	0.482
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.597710e-01	0.252
Reelin signalling pathway	R-HSA-8866376	5.597710e-01	0.252
Suppression of autophagy	R-HSA-9636569	5.597710e-01	0.252
Evasion by RSV of host interferon responses	R-HSA-9833109	4.365423e-01	0.360
Regulation of TP53 Activity through Methylation	R-HSA-6804760	5.053238e-01	0.296
PKA activation in glucagon signalling	R-HSA-164378	5.053238e-01	0.296
Interactions of Vpr with host cellular proteins	R-HSA-176033	4.725118e-01	0.326
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.521254e-01	0.345
RAF/MAP kinase cascade	R-HSA-5673001	2.317512e-01	0.635
Heme signaling	R-HSA-9707616	4.358009e-01	0.361
Ub-specific processing proteases	R-HSA-5689880	1.951544e-01	0.710
MyD88-independent TLR4 cascade	R-HSA-166166	3.599642e-01	0.444
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.599642e-01	0.444
HCMV Late Events	R-HSA-9610379	3.994190e-01	0.399
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	3.680782e-01	0.434
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	5.336397e-01	0.273
Regulation of NPAS4 gene transcription	R-HSA-9768777	4.103572e-01	0.387
p75NTR recruits signalling complexes	R-HSA-209543	5.592094e-01	0.252
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	3.018639e-01	0.520
Smooth Muscle Contraction	R-HSA-445355	4.233944e-01	0.373
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.222221e-01	0.653
NRIF signals cell death from the nucleus	R-HSA-205043	3.528947e-01	0.452
ERK/MAPK targets	R-HSA-198753	3.632518e-01	0.440
TRP channels	R-HSA-3295583	5.163579e-01	0.287
Trafficking and processing of endosomal TLR	R-HSA-1679131	5.592094e-01	0.252
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	4.536006e-01	0.343
Signaling by NTRK3 (TRKC)	R-HSA-9034015	2.128718e-01	0.672
FLT3 Signaling	R-HSA-9607240	4.924984e-01	0.308
Negative regulation of FLT3	R-HSA-9706369	4.155618e-01	0.381
Regulation of gene expression in beta cells	R-HSA-210745	3.909882e-01	0.408
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	5.316601e-01	0.274
Negative regulation of MAPK pathway	R-HSA-5675221	2.210732e-01	0.655
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	2.128718e-01	0.672
RUNX2 regulates bone development	R-HSA-8941326	2.433332e-01	0.614
Nef and signal transduction	R-HSA-164944	2.843409e-01	0.546
Activation of PUMA and translocation to mitochondria	R-HSA-139915	3.271880e-01	0.485
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	1.925230e-01	0.716
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	4.155433e-01	0.381
Muscarinic acetylcholine receptors	R-HSA-390648	5.597710e-01	0.252
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	4.319349e-01	0.365
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	4.649289e-01	0.333
Resolution of Abasic Sites (AP sites)	R-HSA-73933	4.924984e-01	0.308
SARS-CoV-2-host interactions	R-HSA-9705683	2.544201e-01	0.594
Signaling by Interleukins	R-HSA-449147	3.652654e-01	0.437
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	3.223770e-01	0.492
PI3K/AKT Signaling in Cancer	R-HSA-2219528	2.142802e-01	0.669
Protein-protein interactions at synapses	R-HSA-6794362	4.085267e-01	0.389
Tie2 Signaling	R-HSA-210993	5.053238e-01	0.296
Ion homeostasis	R-HSA-5578775	4.754663e-01	0.323
Interleukin-15 signaling	R-HSA-8983432	5.592094e-01	0.252
Signaling by KIT in disease	R-HSA-9669938	4.155433e-01	0.381
Oligomerization of connexins into connexons	R-HSA-190704	2.964260e-01	0.528
Inhibition of membrane repair	R-HSA-9635644	2.964260e-01	0.528
Integration of viral DNA into host genomic DNA	R-HSA-175567	2.843409e-01	0.546
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.434547e-01	0.353
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	2.591637e-01	0.586
TGFBR3 PTM regulation	R-HSA-9839383	3.693150e-01	0.433
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.211877e-01	0.493
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	3.528947e-01	0.452
Cellular response to mitochondrial stress	R-HSA-9840373	4.103572e-01	0.387
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	5.050160e-01	0.297
NADE modulates death signalling	R-HSA-205025	5.050160e-01	0.297
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.090063e-01	0.510
2-LTR circle formation	R-HSA-164843	4.500395e-01	0.347
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	4.155618e-01	0.381
Potential therapeutics for SARS	R-HSA-9679191	1.909537e-01	0.719
RHOBTB3 ATPase cycle	R-HSA-9706019	4.881607e-01	0.311
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	5.597710e-01	0.252
Inositol transporters	R-HSA-429593	5.597710e-01	0.252
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	4.059118e-01	0.392
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.245807e-01	0.280
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	5.245807e-01	0.280
Glucagon signaling in metabolic regulation	R-HSA-163359	5.032035e-01	0.298
TP53 Regulates Metabolic Genes	R-HSA-5628897	4.318524e-01	0.365
Interleukin-2 family signaling	R-HSA-451927	4.725118e-01	0.326
STING mediated induction of host immune responses	R-HSA-1834941	5.336397e-01	0.273
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	4.812862e-01	0.318
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	4.925958e-01	0.308
FOXO-mediated transcription	R-HSA-9614085	3.133169e-01	0.504
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.942746e-01	0.712
Histamine receptors	R-HSA-390650	4.434547e-01	0.353
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	4.103572e-01	0.387
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	4.500395e-01	0.347
Suppression of apoptosis	R-HSA-9635465	4.881607e-01	0.311
MAP kinase activation	R-HSA-450294	5.592494e-01	0.252
Plasma lipoprotein clearance	R-HSA-8964043	4.523089e-01	0.345
The NLRP3 inflammasome	R-HSA-844456	5.336397e-01	0.273
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	2.773981e-01	0.557
Neurodegenerative Diseases	R-HSA-8863678	2.773981e-01	0.557
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	5.562132e-01	0.255
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	3.742415e-01	0.427
MAPK3 (ERK1) activation	R-HSA-110056	1.969960e-01	0.706
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.271880e-01	0.485
The NLRP1 inflammasome	R-HSA-844455	4.434547e-01	0.353
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.050160e-01	0.297
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	3.090063e-01	0.510
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	4.500395e-01	0.347
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	4.155618e-01	0.381
LDL clearance	R-HSA-8964038	4.155433e-01	0.381
SMAC (DIABLO) binds to IAPs	R-HSA-111463	5.597710e-01	0.252
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	5.597710e-01	0.252
Co-inhibition by BTLA	R-HSA-9927353	5.597710e-01	0.252
Unfolded Protein Response (UPR)	R-HSA-381119	2.913151e-01	0.536
Zygotic genome activation (ZGA)	R-HSA-9819196	3.632518e-01	0.440
ChREBP activates metabolic gene expression	R-HSA-163765	2.271346e-01	0.644
Interleukin-35 Signalling	R-HSA-8984722	5.592094e-01	0.252
Regulation of beta-cell development	R-HSA-186712	5.263450e-01	0.279
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	2.340132e-01	0.631
Maturation of nucleoprotein	R-HSA-9694631	5.336397e-01	0.273
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	3.742415e-01	0.427
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	3.271880e-01	0.485
FasL/ CD95L signaling	R-HSA-75157	4.434547e-01	0.353
Regulated proteolysis of p75NTR	R-HSA-193692	4.103572e-01	0.387
Respiratory syncytial virus genome replication	R-HSA-9834752	4.103572e-01	0.387
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	5.597710e-01	0.252
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	5.597710e-01	0.252
SARS-CoV Infections	R-HSA-9679506	4.430909e-01	0.354
Apoptosis induced DNA fragmentation	R-HSA-140342	4.500395e-01	0.347
Josephin domain DUBs	R-HSA-5689877	4.500395e-01	0.347
Activation of kainate receptors upon glutamate binding	R-HSA-451326	3.680782e-01	0.434
IRE1alpha activates chaperones	R-HSA-381070	3.008413e-01	0.522
Uptake and function of anthrax toxins	R-HSA-5210891	4.761405e-01	0.322
XBP1(S) activates chaperone genes	R-HSA-381038	3.255902e-01	0.487
Signaling by Leptin	R-HSA-2586552	4.500395e-01	0.347
Uptake and actions of bacterial toxins	R-HSA-5339562	5.551815e-01	0.256
Interleukin-37 signaling	R-HSA-9008059	2.497555e-01	0.602
Assembly of Viral Components at the Budding Site	R-HSA-168316	5.597710e-01	0.252
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	4.155433e-01	0.381
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	5.053238e-01	0.296
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	5.600522e-01	0.252
Protein hydroxylation	R-HSA-9629569	5.610144e-01	0.251
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.630404e-01	0.249
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.630404e-01	0.249
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.636462e-01	0.249
Inflammasomes	R-HSA-622312	5.636462e-01	0.249
Regulation of TP53 Degradation	R-HSA-6804757	5.665431e-01	0.247
Lysosome Vesicle Biogenesis	R-HSA-432720	5.665431e-01	0.247
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	5.665431e-01	0.247
FLT3 signaling in disease	R-HSA-9682385	5.665431e-01	0.247
Netrin-1 signaling	R-HSA-373752	5.695024e-01	0.245
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	5.718520e-01	0.243
NCAM signaling for neurite out-growth	R-HSA-375165	5.753295e-01	0.240
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	5.753295e-01	0.240
Hedgehog 'on' state	R-HSA-5632684	5.781487e-01	0.238
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	5.808955e-01	0.236
mRNA Capping	R-HSA-72086	5.863148e-01	0.232
Impaired BRCA2 binding to RAD51	R-HSA-9709570	5.863148e-01	0.232
Signaling by CSF3 (G-CSF)	R-HSA-9674555	5.863148e-01	0.232
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.863148e-01	0.232
Regulation of CDH11 Expression and Function	R-HSA-9759475	5.863148e-01	0.232
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	5.863148e-01	0.232
TRAF6 mediated IRF7 activation	R-HSA-933541	5.867183e-01	0.232
SHC-mediated cascade:FGFR3	R-HSA-5654704	5.873909e-01	0.231
Lagging Strand Synthesis	R-HSA-69186	5.873909e-01	0.231
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	5.873909e-01	0.231
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	5.873909e-01	0.231
PKA-mediated phosphorylation of CREB	R-HSA-111931	5.873909e-01	0.231
Early Phase of HIV Life Cycle	R-HSA-162594	5.873909e-01	0.231
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	5.873909e-01	0.231
Signaling by FGFR3	R-HSA-5654741	5.878526e-01	0.231
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	5.911356e-01	0.228
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	5.919976e-01	0.228
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	5.919976e-01	0.228
Formation of axial mesoderm	R-HSA-9796292	5.919976e-01	0.228
Membrane binding and targetting of GAG proteins	R-HSA-174490	5.919976e-01	0.228
Maturation of nucleoprotein	R-HSA-9683610	5.919976e-01	0.228
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	5.930182e-01	0.227
SARS-CoV-2 Infection	R-HSA-9694516	5.967151e-01	0.224
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	6.057883e-01	0.218
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	6.059791e-01	0.218
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.063704e-01	0.217
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.066503e-01	0.217
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	6.082814e-01	0.216
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	6.082814e-01	0.216
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	6.082814e-01	0.216
Nef Mediated CD8 Down-regulation	R-HSA-182218	6.084719e-01	0.216
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	6.084719e-01	0.216
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.084719e-01	0.216
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	6.084719e-01	0.216
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.084719e-01	0.216
IkBA variant leads to EDA-ID	R-HSA-5603029	6.084719e-01	0.216
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.084719e-01	0.216
Defective CSF2RA causes SMDP4	R-HSA-5688890	6.084719e-01	0.216
Defective CSF2RB causes SMDP5	R-HSA-5688849	6.084719e-01	0.216
Signaling by RNF43 mutants	R-HSA-5340588	6.084719e-01	0.216
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	6.084719e-01	0.216
Synthesis of dolichyl-phosphate mannose	R-HSA-162699	6.084719e-01	0.216
CDC6 association with the ORC:origin complex	R-HSA-68689	6.084719e-01	0.216
Synthesis of PS	R-HSA-1483101	6.084719e-01	0.216
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	6.084719e-01	0.216
Release of apoptotic factors from the mitochondria	R-HSA-111457	6.084719e-01	0.216
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	6.084719e-01	0.216
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	6.084719e-01	0.216
TRAIL signaling	R-HSA-75158	6.084719e-01	0.216
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	6.084719e-01	0.216
SHC-mediated cascade:FGFR4	R-HSA-5654719	6.127272e-01	0.213
Cellular responses to mechanical stimuli	R-HSA-9855142	6.146619e-01	0.211
Signaling by NOTCH4	R-HSA-9013694	6.219830e-01	0.206
Signaling by FGFR in disease	R-HSA-1226099	6.219830e-01	0.206
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	6.222155e-01	0.206
Removal of the Flap Intermediate	R-HSA-69166	6.229286e-01	0.206
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	6.229286e-01	0.206
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.240328e-01	0.205
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.240328e-01	0.205
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.240328e-01	0.205
Regulation of TP53 Expression and Degradation	R-HSA-6806003	6.254741e-01	0.204
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.285985e-01	0.202
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	6.295169e-01	0.201
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	6.295169e-01	0.201
Budding and maturation of HIV virion	R-HSA-162588	6.295169e-01	0.201
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	6.369949e-01	0.196
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	6.369949e-01	0.196
RAF-independent MAPK1/3 activation	R-HSA-112409	6.369949e-01	0.196
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.369949e-01	0.196
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	6.382981e-01	0.195
Co-stimulation by CD28	R-HSA-389356	6.403339e-01	0.194
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	6.440088e-01	0.191
Generation of second messenger molecules	R-HSA-202433	6.440088e-01	0.191
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.440088e-01	0.191
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.440088e-01	0.191
Glycolysis	R-HSA-70171	6.482825e-01	0.188
Host Interactions of HIV factors	R-HSA-162909	6.490811e-01	0.188
UCH proteinases	R-HSA-5689603	6.498320e-01	0.187
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.499994e-01	0.187
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.517877e-01	0.186
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	6.517877e-01	0.186
Signaling by LTK in cancer	R-HSA-9842640	6.517877e-01	0.186
STAT5 Activation	R-HSA-9645135	6.517877e-01	0.186
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	6.517877e-01	0.186
Metabolism of ingested MeSeO2H into MeSeH	R-HSA-5263617	6.517877e-01	0.186
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.517877e-01	0.186
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.517877e-01	0.186
G2/M DNA replication checkpoint	R-HSA-69478	6.517877e-01	0.186
Regulation of NFE2L2 gene expression	R-HSA-9818749	6.517877e-01	0.186
Chylomicron clearance	R-HSA-8964026	6.517877e-01	0.186
Leukotriene receptors	R-HSA-391906	6.517877e-01	0.186
Neurofascin interactions	R-HSA-447043	6.517877e-01	0.186
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	6.520121e-01	0.186
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	6.520121e-01	0.186
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	6.520121e-01	0.186
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	6.520121e-01	0.186
RNA Polymerase III Chain Elongation	R-HSA-73780	6.520121e-01	0.186
G beta:gamma signalling through BTK	R-HSA-8964315	6.520121e-01	0.186
Processive synthesis on the lagging strand	R-HSA-69183	6.520121e-01	0.186
Telomere C-strand synthesis initiation	R-HSA-174430	6.520121e-01	0.186
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	6.520121e-01	0.186
p75NTR signals via NF-kB	R-HSA-193639	6.520121e-01	0.186
Biotin transport and metabolism	R-HSA-196780	6.520121e-01	0.186
Toll-like Receptor Cascades	R-HSA-168898	6.555950e-01	0.183
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.569102e-01	0.182
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.569102e-01	0.182
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	6.601774e-01	0.180
Syndecan interactions	R-HSA-3000170	6.601774e-01	0.180
Free fatty acids regulate insulin secretion	R-HSA-400451	6.601774e-01	0.180
Growth hormone receptor signaling	R-HSA-982772	6.601774e-01	0.180
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	6.619580e-01	0.179
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	6.626469e-01	0.179
Extension of Telomeres	R-HSA-180786	6.686135e-01	0.175
IPs transport between nucleus and cytosol	R-HSA-1855170	6.697133e-01	0.174
Regulation of necroptotic cell death	R-HSA-5675482	6.697133e-01	0.174
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.697133e-01	0.174
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.697133e-01	0.174
Cardiogenesis	R-HSA-9733709	6.697133e-01	0.174
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	6.697133e-01	0.174
Regulation of RAS by GAPs	R-HSA-5658442	6.730047e-01	0.172
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.792782e-01	0.168
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	6.792782e-01	0.168
Killing mechanisms	R-HSA-9664420	6.792782e-01	0.168
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	6.792782e-01	0.168
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	6.792782e-01	0.168
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.792782e-01	0.168
Differentiation of T cells	R-HSA-9945266	6.792782e-01	0.168
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	6.792782e-01	0.168
Activation of SMO	R-HSA-5635838	6.792782e-01	0.168
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	6.792782e-01	0.168
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	6.793093e-01	0.168
HIV Transcription Initiation	R-HSA-167161	6.793093e-01	0.168
RNA Polymerase II Transcription Initiation	R-HSA-75953	6.793093e-01	0.168
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	6.793093e-01	0.168
Signaling by FGFR1 in disease	R-HSA-5655302	6.793093e-01	0.168
SHC-mediated cascade:FGFR1	R-HSA-5654688	6.822687e-01	0.166
CD209 (DC-SIGN) signaling	R-HSA-5621575	6.822687e-01	0.166
Platelet activation, signaling and aggregation	R-HSA-76002	6.867990e-01	0.163
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	6.886076e-01	0.162
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	6.886488e-01	0.162
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	6.886488e-01	0.162
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.893396e-01	0.162
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.903137e-01	0.161
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	6.903137e-01	0.161
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	6.903137e-01	0.161
Recycling of eIF2:GDP	R-HSA-72731	6.903137e-01	0.161
Disinhibition of SNARE formation	R-HSA-114516	6.903137e-01	0.161
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	6.903137e-01	0.161
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	6.903137e-01	0.161
MET activates PI3K/AKT signaling	R-HSA-8851907	6.903137e-01	0.161
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.903137e-01	0.161
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.903137e-01	0.161
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.903137e-01	0.161
VLDL clearance	R-HSA-8964046	6.903137e-01	0.161
Regulation of PTEN localization	R-HSA-8948747	6.903137e-01	0.161
Netrin mediated repulsion signals	R-HSA-418886	6.903137e-01	0.161
Cation-coupled Chloride cotransporters	R-HSA-426117	6.903137e-01	0.161
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.903137e-01	0.161
CHL1 interactions	R-HSA-447041	6.903137e-01	0.161
Maturation of replicase proteins	R-HSA-9694301	6.903137e-01	0.161
Transcriptional regulation by RUNX2	R-HSA-8878166	6.913872e-01	0.160
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.928642e-01	0.159
Cyclin E associated events during G1/S transition	R-HSA-69202	6.928642e-01	0.159
Interleukin-17 signaling	R-HSA-448424	6.928642e-01	0.159
Response of endothelial cells to shear stress	R-HSA-9860931	6.941414e-01	0.159
Aquaporin-mediated transport	R-HSA-445717	6.975081e-01	0.156
Formation of paraxial mesoderm	R-HSA-9793380	6.975081e-01	0.156
Acyl chain remodelling of PS	R-HSA-1482801	7.032714e-01	0.153
VEGFR2 mediated cell proliferation	R-HSA-5218921	7.032714e-01	0.153
Transcriptional Regulation by NPAS4	R-HSA-9634815	7.037118e-01	0.153
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	7.047730e-01	0.152
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	7.047730e-01	0.152
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	7.047730e-01	0.152
Dual Incision in GG-NER	R-HSA-5696400	7.068017e-01	0.151
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	7.068017e-01	0.151
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	7.068017e-01	0.151
Signal amplification	R-HSA-392518	7.068017e-01	0.151
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.068017e-01	0.151
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	7.068017e-01	0.151
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	7.068017e-01	0.151
NOD1/2 Signaling Pathway	R-HSA-168638	7.068017e-01	0.151
Cellular response to chemical stress	R-HSA-9711123	7.071401e-01	0.150
Integration of energy metabolism	R-HSA-163685	7.088491e-01	0.149
Signaling by PDGF	R-HSA-186797	7.113211e-01	0.148
RNA Polymerase II Promoter Escape	R-HSA-73776	7.121869e-01	0.147
Response of Mtb to phagocytosis	R-HSA-9637690	7.121869e-01	0.147
Nucleotide Excision Repair	R-HSA-5696398	7.156638e-01	0.145
MET activates PTK2 signaling	R-HSA-8874081	7.231962e-01	0.141
Signaling by FLT3 fusion proteins	R-HSA-9703465	7.231962e-01	0.141
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	7.231962e-01	0.141
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	7.241724e-01	0.140
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	7.245791e-01	0.140
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.245791e-01	0.140
phospho-PLA2 pathway	R-HSA-111995	7.245791e-01	0.140
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.245791e-01	0.140
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.245791e-01	0.140
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	7.245791e-01	0.140
Interleukin-23 signaling	R-HSA-9020933	7.245791e-01	0.140
Adrenoceptors	R-HSA-390696	7.245791e-01	0.140
FGFR1b ligand binding and activation	R-HSA-190370	7.245791e-01	0.140
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	7.245791e-01	0.140
SLC-mediated bile acid transport	R-HSA-9958517	7.245791e-01	0.140
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	7.245791e-01	0.140
Sodium/Proton exchangers	R-HSA-425986	7.245791e-01	0.140
G1/S DNA Damage Checkpoints	R-HSA-69615	7.247053e-01	0.140
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	7.277058e-01	0.138
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.285546e-01	0.138
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	7.285546e-01	0.138
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	7.285546e-01	0.138
Elevation of cytosolic Ca2+ levels	R-HSA-139853	7.285546e-01	0.138
Glycogen storage diseases	R-HSA-3229121	7.285546e-01	0.138
Specification of primordial germ cells	R-HSA-9827857	7.285546e-01	0.138
Regulation of insulin secretion	R-HSA-422356	7.291638e-01	0.137
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	7.324069e-01	0.135
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	7.329247e-01	0.135
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.333348e-01	0.135
Ion transport by P-type ATPases	R-HSA-936837	7.376583e-01	0.132
GPVI-mediated activation cascade	R-HSA-114604	7.407654e-01	0.130
FGFR2 mutant receptor activation	R-HSA-1839126	7.407654e-01	0.130
RNA Polymerase I Transcription Termination	R-HSA-73863	7.420603e-01	0.130
SHC-mediated cascade:FGFR2	R-HSA-5654699	7.420603e-01	0.130
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.420603e-01	0.130
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	7.426113e-01	0.129
Asymmetric localization of PCP proteins	R-HSA-4608870	7.426113e-01	0.129
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	7.426113e-01	0.129
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	7.426113e-01	0.129
Leishmania phagocytosis	R-HSA-9664417	7.447714e-01	0.128
Parasite infection	R-HSA-9664407	7.447714e-01	0.128
FCGR3A-mediated phagocytosis	R-HSA-9664422	7.447714e-01	0.128
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.461069e-01	0.127
Cellular response to hypoxia	R-HSA-1234174	7.501790e-01	0.125
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	7.506900e-01	0.125
Mismatch Repair	R-HSA-5358508	7.506900e-01	0.125
Platelet sensitization by LDL	R-HSA-432142	7.506900e-01	0.125
Vitamin D (calciferol) metabolism	R-HSA-196791	7.506900e-01	0.125
Organelle biogenesis and maintenance	R-HSA-1852241	7.524148e-01	0.124
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.532869e-01	0.123
Adaptive Immune System	R-HSA-1280218	7.550369e-01	0.122
Interleukin-21 signaling	R-HSA-9020958	7.550551e-01	0.122
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	7.550551e-01	0.122
Inactivation of CDC42 and RAC1	R-HSA-428543	7.550551e-01	0.122
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.550551e-01	0.122
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.550551e-01	0.122
Regulation of signaling by NODAL	R-HSA-1433617	7.550551e-01	0.122
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.550551e-01	0.122
Regulation of CDH11 gene transcription	R-HSA-9762293	7.550551e-01	0.122
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	7.550551e-01	0.122
Interleukin-1 processing	R-HSA-448706	7.550551e-01	0.122
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.550551e-01	0.122
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.550551e-01	0.122
Butyrophilin (BTN) family interactions	R-HSA-8851680	7.550551e-01	0.122
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.557554e-01	0.122
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	7.565892e-01	0.121
Degradation of DVL	R-HSA-4641258	7.565892e-01	0.121
Diseases of DNA repair	R-HSA-9675135	7.569070e-01	0.121
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	7.570360e-01	0.121
Telomere Extension By Telomerase	R-HSA-171319	7.598860e-01	0.119
Phase 0 - rapid depolarisation	R-HSA-5576892	7.598860e-01	0.119
Pyroptosis	R-HSA-5620971	7.598860e-01	0.119
Viral Infection Pathways	R-HSA-9824446	7.617329e-01	0.118
TCR signaling	R-HSA-202403	7.651525e-01	0.116
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	7.697511e-01	0.114
IKK complex recruitment mediated by RIP1	R-HSA-937041	7.712521e-01	0.113
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	7.712521e-01	0.113
Other interleukin signaling	R-HSA-449836	7.712521e-01	0.113
Crosslinking of collagen fibrils	R-HSA-2243919	7.712521e-01	0.113
RIPK1-mediated regulated necrosis	R-HSA-5213460	7.716554e-01	0.113
Kidney development	R-HSA-9830369	7.739275e-01	0.111
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	7.751585e-01	0.111
Downstream signaling of activated FGFR3	R-HSA-5654708	7.767005e-01	0.110
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	7.791133e-01	0.108
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	7.791133e-01	0.108
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	7.821603e-01	0.107
Regulation of the apoptosome activity	R-HSA-9627069	7.821603e-01	0.107
Formation of apoptosome	R-HSA-111458	7.821603e-01	0.107
Regulation of CDH11 function	R-HSA-9762292	7.821603e-01	0.107
Binding and entry of HIV virion	R-HSA-173107	7.821603e-01	0.107
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.821603e-01	0.107
Formation of intermediate mesoderm	R-HSA-9761174	7.821603e-01	0.107
Pexophagy	R-HSA-9664873	7.821603e-01	0.107
Defective factor IX causes hemophilia B	R-HSA-9668250	7.821603e-01	0.107
Maturation of spike protein	R-HSA-9683686	7.821603e-01	0.107
Gluconeogenesis	R-HSA-70263	7.836937e-01	0.106
Regulated Necrosis	R-HSA-5218859	7.851601e-01	0.105
Stabilization of p53	R-HSA-69541	7.859784e-01	0.105
NS1 Mediated Effects on Host Pathways	R-HSA-168276	7.859784e-01	0.105
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	7.902044e-01	0.102
Chaperonin-mediated protein folding	R-HSA-390466	7.902284e-01	0.102
Regulation of PD-L1(CD274) translation	R-HSA-9909620	7.903182e-01	0.102
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.903182e-01	0.102
Signaling by NODAL	R-HSA-1181150	7.903182e-01	0.102
Glycogen synthesis	R-HSA-3322077	7.903182e-01	0.102
Signal transduction by L1	R-HSA-445144	7.903182e-01	0.102
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.918340e-01	0.101
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	7.925343e-01	0.101
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	7.925343e-01	0.101
DAP12 signaling	R-HSA-2424491	7.925343e-01	0.101
Downstream signaling of activated FGFR4	R-HSA-5654716	7.925343e-01	0.101
Formation of a pool of free 40S subunits	R-HSA-72689	7.933728e-01	0.101
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	7.953318e-01	0.099
Gap junction trafficking and regulation	R-HSA-157858	7.962020e-01	0.099
Degradation of CDH1	R-HSA-9766229	7.962020e-01	0.099
Formation of Incision Complex in GG-NER	R-HSA-5696395	7.995751e-01	0.097
Negative regulation of NOTCH4 signaling	R-HSA-9604323	7.995751e-01	0.097
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.037942e-01	0.095
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.037942e-01	0.095
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.062676e-01	0.094
vRNP Assembly	R-HSA-192905	8.062676e-01	0.094
Bicarbonate transporters	R-HSA-425381	8.062676e-01	0.094
Transport of RCbl within the body	R-HSA-9758890	8.062676e-01	0.094
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	8.062676e-01	0.094
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.062676e-01	0.094
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.062676e-01	0.094
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.062676e-01	0.094
Interleukin-2 signaling	R-HSA-9020558	8.062676e-01	0.094
Dissolution of Fibrin Clot	R-HSA-75205	8.062676e-01	0.094
ER to Golgi Anterograde Transport	R-HSA-199977	8.075921e-01	0.093
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	8.079674e-01	0.093
G-protein activation	R-HSA-202040	8.079674e-01	0.093
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	8.079674e-01	0.093
Basigin interactions	R-HSA-210991	8.079674e-01	0.093
Prevention of phagosomal-lysosomal fusion	R-HSA-9636383	8.079674e-01	0.093
Signaling by FGFR2 in disease	R-HSA-5655253	8.081348e-01	0.093
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	8.124644e-01	0.090
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	8.124644e-01	0.090
Cytokine Signaling in Immune system	R-HSA-1280215	8.146467e-01	0.089
Muscle contraction	R-HSA-397014	8.160973e-01	0.088
Cargo trafficking to the periciliary membrane	R-HSA-5620920	8.163437e-01	0.088
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	8.167373e-01	0.088
Viral Messenger RNA Synthesis	R-HSA-168325	8.170704e-01	0.088
Activation of NF-kappaB in B cells	R-HSA-1169091	8.195047e-01	0.086
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.213957e-01	0.085
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	8.213957e-01	0.085
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	8.216151e-01	0.085
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	8.242797e-01	0.084
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	8.242797e-01	0.084
Assembly Of The HIV Virion	R-HSA-175474	8.242797e-01	0.084
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.246666e-01	0.084
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	8.246666e-01	0.084
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.246666e-01	0.084
Cytochrome c-mediated apoptotic response	R-HSA-111461	8.277083e-01	0.082
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	8.277083e-01	0.082
Plasmalogen biosynthesis	R-HSA-75896	8.277083e-01	0.082
NF-kB is activated and signals survival	R-HSA-209560	8.277083e-01	0.082
ERKs are inactivated	R-HSA-202670	8.277083e-01	0.082
Activation of RAC1	R-HSA-428540	8.277083e-01	0.082
Endosomal/Vacuolar pathway	R-HSA-1236977	8.277083e-01	0.082
rRNA processing in the nucleus and cytosol	R-HSA-8868773	8.344105e-01	0.079
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	8.344959e-01	0.079
Hedgehog 'off' state	R-HSA-5610787	8.355843e-01	0.078
Glucose metabolism	R-HSA-70326	8.385059e-01	0.076
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	8.393349e-01	0.076
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	8.393349e-01	0.076
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	8.400697e-01	0.076
Amino acids regulate mTORC1	R-HSA-9639288	8.406121e-01	0.075
Eukaryotic Translation Elongation	R-HSA-156842	8.426823e-01	0.074
Protein folding	R-HSA-391251	8.426823e-01	0.074
IGF1R signaling cascade	R-HSA-2428924	8.462096e-01	0.073
Resolution of D-Loop Structures	R-HSA-5693537	8.467597e-01	0.072
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	8.467597e-01	0.072
Effects of PIP2 hydrolysis	R-HSA-114508	8.467597e-01	0.072
Miscellaneous transport and binding events	R-HSA-5223345	8.467597e-01	0.072
Regulation of IFNG signaling	R-HSA-877312	8.467772e-01	0.072
Serotonin clearance from the synaptic cleft	R-HSA-380615	8.467772e-01	0.072
Diseases associated with surfactant metabolism	R-HSA-5687613	8.467772e-01	0.072
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	8.467772e-01	0.072
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	8.467772e-01	0.072
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.467772e-01	0.072
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	8.467772e-01	0.072
OAS antiviral response	R-HSA-8983711	8.467772e-01	0.072
PI Metabolism	R-HSA-1483255	8.504795e-01	0.070
MAPK6/MAPK4 signaling	R-HSA-5687128	8.508563e-01	0.070
Regulation of PTEN mRNA translation	R-HSA-8943723	8.532113e-01	0.069
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	8.532113e-01	0.069
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	8.532113e-01	0.069
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	8.532113e-01	0.069
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	8.550409e-01	0.068
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	8.563214e-01	0.067
Inositol phosphate metabolism	R-HSA-1483249	8.578736e-01	0.067
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	8.582255e-01	0.066
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	8.582255e-01	0.066
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.582255e-01	0.066
G alpha (z) signalling events	R-HSA-418597	8.596456e-01	0.066
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	8.609574e-01	0.065
CD28 dependent Vav1 pathway	R-HSA-389359	8.637366e-01	0.064
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	8.637366e-01	0.064
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	8.637366e-01	0.064
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.637366e-01	0.064
Acetylcholine binding and downstream events	R-HSA-181431	8.637366e-01	0.064
FGFR1c ligand binding and activation	R-HSA-190373	8.637366e-01	0.064
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	8.637366e-01	0.064
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.637366e-01	0.064
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.637366e-01	0.064
Thromboxane signalling through TP receptor	R-HSA-428930	8.659853e-01	0.062
Mitochondrial RNA degradation	R-HSA-9836573	8.659853e-01	0.062
Complex III assembly	R-HSA-9865881	8.659853e-01	0.062
Signaling by Hedgehog	R-HSA-5358351	8.667485e-01	0.062
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	8.670554e-01	0.062
Somitogenesis	R-HSA-9824272	8.670554e-01	0.062
Downstream signaling of activated FGFR2	R-HSA-5654696	8.689322e-01	0.061
Downstream signaling of activated FGFR1	R-HSA-5654687	8.689322e-01	0.061
RSV-host interactions	R-HSA-9833110	8.708059e-01	0.060
Eukaryotic Translation Termination	R-HSA-72764	8.715190e-01	0.060
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	8.761663e-01	0.057
Regulation of CDH1 Function	R-HSA-9764561	8.767370e-01	0.057
Adipogenesis	R-HSA-9843745	8.771044e-01	0.057
Activation of G protein gated Potassium channels	R-HSA-1296041	8.777310e-01	0.057
G protein gated Potassium channels	R-HSA-1296059	8.777310e-01	0.057
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.777310e-01	0.057
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.777310e-01	0.057
Laminin interactions	R-HSA-3000157	8.777310e-01	0.057
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	8.788198e-01	0.056
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	8.788198e-01	0.056
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.788198e-01	0.056
Signaling by FGFR4 in disease	R-HSA-5655291	8.788198e-01	0.056
Hydrolysis of LPC	R-HSA-1483115	8.788198e-01	0.056
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.788198e-01	0.056
Acyl chain remodeling of CL	R-HSA-1482798	8.788198e-01	0.056
Zinc transporters	R-HSA-435354	8.788198e-01	0.056
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.788198e-01	0.056
Interferon gamma signaling	R-HSA-877300	8.796735e-01	0.056
Peptide chain elongation	R-HSA-156902	8.796959e-01	0.056
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.845974e-01	0.053
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	8.847316e-01	0.053
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.862840e-01	0.052
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.885195e-01	0.051
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.885195e-01	0.051
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	8.885195e-01	0.051
Suppression of phagosomal maturation	R-HSA-9637687	8.885195e-01	0.051
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	8.889978e-01	0.051
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.922341e-01	0.050
Translesion synthesis by REV1	R-HSA-110312	8.922341e-01	0.050
Protein lipoylation	R-HSA-9857492	8.922341e-01	0.050
Signaling by Activin	R-HSA-1502540	8.922341e-01	0.050
p38MAPK events	R-HSA-171007	8.922341e-01	0.050
Transport and metabolism of PAPS	R-HSA-174362	8.922341e-01	0.050
Protein methylation	R-HSA-8876725	8.922341e-01	0.050
Other semaphorin interactions	R-HSA-416700	8.922341e-01	0.050
Metal ion SLC transporters	R-HSA-425410	8.927756e-01	0.049
Interleukin-1 family signaling	R-HSA-446652	8.932874e-01	0.049
Elastic fibre formation	R-HSA-1566948	8.968805e-01	0.047
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	8.968805e-01	0.047
SLC-mediated transport of inorganic anions	R-HSA-9958790	8.968805e-01	0.047
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.984185e-01	0.047
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	8.984185e-01	0.047
Cristae formation	R-HSA-8949613	8.984185e-01	0.047
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.984185e-01	0.047
Insulin processing	R-HSA-264876	8.984185e-01	0.047
RAB geranylgeranylation	R-HSA-8873719	8.990349e-01	0.046
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.990349e-01	0.046
Translesion synthesis by POLI	R-HSA-5656121	9.041642e-01	0.044
Phosphorylation of the APC/C	R-HSA-176412	9.041642e-01	0.044
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	9.041642e-01	0.044
Class I peroxisomal membrane protein import	R-HSA-9603798	9.041642e-01	0.044
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	9.041642e-01	0.044
Regulation of NF-kappa B signaling	R-HSA-9758274	9.041642e-01	0.044
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	9.041642e-01	0.044
Virus Assembly and Release	R-HSA-168268	9.041642e-01	0.044
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.056470e-01	0.043
Influenza Viral RNA Transcription and Replication	R-HSA-168273	9.064777e-01	0.043
Interleukin-1 signaling	R-HSA-9020702	9.065787e-01	0.043
Insulin receptor recycling	R-HSA-77387	9.074930e-01	0.042
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	9.074930e-01	0.042
Pyrimidine salvage	R-HSA-73614	9.074930e-01	0.042
Mitochondrial protein import	R-HSA-1268020	9.118778e-01	0.040
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.118778e-01	0.040
Glycogen metabolism	R-HSA-8982491	9.124076e-01	0.040
Translesion synthesis by POLK	R-HSA-5655862	9.147743e-01	0.039
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	9.147743e-01	0.039
Glycine degradation	R-HSA-6783984	9.147743e-01	0.039
Heme assimilation	R-HSA-9927020	9.147743e-01	0.039
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	9.147743e-01	0.039
Passive transport by Aquaporins	R-HSA-432047	9.147743e-01	0.039
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.147743e-01	0.039
Synthesis of PG	R-HSA-1483148	9.147743e-01	0.039
Coenzyme A biosynthesis	R-HSA-196783	9.147743e-01	0.039
Transcriptional regulation of testis differentiation	R-HSA-9690406	9.147743e-01	0.039
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.147743e-01	0.039
Platelet calcium homeostasis	R-HSA-418360	9.158039e-01	0.038
Glucagon-type ligand receptors	R-HSA-420092	9.158039e-01	0.038
Hh mutants are degraded by ERAD	R-HSA-5362768	9.193460e-01	0.037
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.193460e-01	0.037
VEGFR2 mediated vascular permeability	R-HSA-5218920	9.193460e-01	0.037
Maturation of spike protein	R-HSA-9694548	9.193460e-01	0.037
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.202205e-01	0.036
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.208435e-01	0.036
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.223477e-01	0.035
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.223477e-01	0.035
Gastrulation	R-HSA-9758941	9.223619e-01	0.035
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.236327e-01	0.035
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	9.242102e-01	0.034
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	9.242102e-01	0.034
Regulation of FZD by ubiquitination	R-HSA-4641263	9.242102e-01	0.034
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	R-HSA-2408550	9.242102e-01	0.034
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.242102e-01	0.034
Choline catabolism	R-HSA-6798163	9.242102e-01	0.034
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.242102e-01	0.034
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.242102e-01	0.034
Influenza Infection	R-HSA-168255	9.250763e-01	0.034
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.257787e-01	0.033
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.257787e-01	0.033
Degradation of CRY and PER proteins	R-HSA-9932298	9.257787e-01	0.033
Intra-Golgi traffic	R-HSA-6811438	9.257787e-01	0.033
Translation of Structural Proteins	R-HSA-9683701	9.257787e-01	0.033
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.260153e-01	0.033
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	9.260153e-01	0.033
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.303631e-01	0.031
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.303631e-01	0.031
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.303631e-01	0.031
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.313131e-01	0.031
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.314281e-01	0.031
C-type lectin receptors (CLRs)	R-HSA-5621481	9.316713e-01	0.031
Translation of Structural Proteins	R-HSA-9694635	9.319127e-01	0.031
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	9.321620e-01	0.031
Transport of connexons to the plasma membrane	R-HSA-190872	9.326019e-01	0.030
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	9.326019e-01	0.030
FGFR1 ligand binding and activation	R-HSA-190242	9.326019e-01	0.030
FOXO-mediated transcription of cell death genes	R-HSA-9614657	9.326019e-01	0.030
Synaptic adhesion-like molecules	R-HSA-8849932	9.326019e-01	0.030
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.364800e-01	0.029
Inwardly rectifying K+ channels	R-HSA-1296065	9.367167e-01	0.028
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.372526e-01	0.028
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	9.393498e-01	0.027
PI-3K cascade:FGFR3	R-HSA-5654710	9.400649e-01	0.027
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	9.400649e-01	0.027
Impaired BRCA2 binding to PALB2	R-HSA-9709603	9.400649e-01	0.027
Translesion Synthesis by POLH	R-HSA-110320	9.400649e-01	0.027
Germ layer formation at gastrulation	R-HSA-9754189	9.400649e-01	0.027
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.400649e-01	0.027
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.400649e-01	0.027
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.400649e-01	0.027
Diseases of hemostasis	R-HSA-9671793	9.400649e-01	0.027
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.400649e-01	0.027
Stimuli-sensing channels	R-HSA-2672351	9.404758e-01	0.027
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	9.411915e-01	0.026
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	9.411915e-01	0.026
Mitochondrial biogenesis	R-HSA-1592230	9.414763e-01	0.026
Gap junction trafficking	R-HSA-190828	9.423532e-01	0.026
DAP12 interactions	R-HSA-2172127	9.423532e-01	0.026
Amine ligand-binding receptors	R-HSA-375280	9.423532e-01	0.026
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	9.425175e-01	0.026
Platelet degranulation	R-HSA-114608	9.427373e-01	0.026
Downstream TCR signaling	R-HSA-202424	9.434767e-01	0.025
PKR-mediated signaling	R-HSA-9833482	9.443074e-01	0.025
PI-3K cascade:FGFR4	R-HSA-5654720	9.467019e-01	0.024
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	9.467019e-01	0.024
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	9.467019e-01	0.024
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	9.467019e-01	0.024
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	9.467019e-01	0.024
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.467019e-01	0.024
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.467019e-01	0.024
Acyl chain remodelling of PI	R-HSA-1482922	9.467019e-01	0.024
Creatine metabolism	R-HSA-71288	9.467019e-01	0.024
Eicosanoid ligand-binding receptors	R-HSA-391903	9.467019e-01	0.024
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.470668e-01	0.024
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.470668e-01	0.024
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	9.470668e-01	0.024
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	9.470668e-01	0.024
Fanconi Anemia Pathway	R-HSA-6783310	9.470668e-01	0.024
Acyl chain remodelling of PC	R-HSA-1482788	9.478101e-01	0.023
Vpu mediated degradation of CD4	R-HSA-180534	9.478101e-01	0.023
Dual incision in TC-NER	R-HSA-6782135	9.496709e-01	0.022
Ribosome-associated quality control	R-HSA-9948299	9.497867e-01	0.022
Selenocysteine synthesis	R-HSA-2408557	9.499422e-01	0.022
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.499499e-01	0.022
Cellular response to starvation	R-HSA-9711097	9.499499e-01	0.022
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	9.514196e-01	0.022
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.514196e-01	0.022
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.514196e-01	0.022
Ion channel transport	R-HSA-983712	9.524636e-01	0.021
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.526043e-01	0.021
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	9.526043e-01	0.021
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.526043e-01	0.021
Acyl chain remodelling of PG	R-HSA-1482925	9.526043e-01	0.021
Calnexin/calreticulin cycle	R-HSA-901042	9.526359e-01	0.021
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	9.526359e-01	0.021
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.526359e-01	0.021
NPAS4 regulates expression of target genes	R-HSA-9768919	9.526359e-01	0.021
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	9.535021e-01	0.021
Regulation of mitotic cell cycle	R-HSA-453276	9.535021e-01	0.021
Cytoprotection by HMOX1	R-HSA-9707564	9.546419e-01	0.020
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	9.554363e-01	0.020
Synthesis of PC	R-HSA-1483191	9.554363e-01	0.020
Hemostasis	R-HSA-109582	9.557942e-01	0.020
Viral mRNA Translation	R-HSA-192823	9.558062e-01	0.020
Acyl chain remodelling of PE	R-HSA-1482839	9.570332e-01	0.019
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.570332e-01	0.019
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.570332e-01	0.019
Transferrin endocytosis and recycling	R-HSA-917977	9.570332e-01	0.019
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.570332e-01	0.019
Regulation of Apoptosis	R-HSA-169911	9.570332e-01	0.019
Parasitic Infection Pathways	R-HSA-9824443	9.570731e-01	0.019
Leishmania infection	R-HSA-9658195	9.570731e-01	0.019
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.578534e-01	0.019
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.578534e-01	0.019
Mitochondrial calcium ion transport	R-HSA-8949215	9.578534e-01	0.019
Intraflagellar transport	R-HSA-5620924	9.591404e-01	0.018
Formation of the cornified envelope	R-HSA-6809371	9.608245e-01	0.017
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.610379e-01	0.017
Glycosphingolipid transport	R-HSA-9845576	9.610379e-01	0.017
Protein localization	R-HSA-9609507	9.623981e-01	0.017
PI-3K cascade:FGFR1	R-HSA-5654689	9.625213e-01	0.017
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.625213e-01	0.017
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.625213e-01	0.017
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.625213e-01	0.017
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	9.625213e-01	0.017
Neurotoxicity of clostridium toxins	R-HSA-168799	9.625213e-01	0.017
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.625540e-01	0.017
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	9.633560e-01	0.016
tRNA processing in the nucleus	R-HSA-6784531	9.633560e-01	0.016
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.642831e-01	0.016
Voltage gated Potassium channels	R-HSA-1296072	9.646828e-01	0.016
Degradation of AXIN	R-HSA-4641257	9.646828e-01	0.016
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.646828e-01	0.016
NCAM1 interactions	R-HSA-419037	9.646828e-01	0.016
SLC-mediated transport of organic cations	R-HSA-549127	9.646828e-01	0.016
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.654494e-01	0.015
PI3K Cascade	R-HSA-109704	9.656978e-01	0.015
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.666726e-01	0.015
Interleukin-20 family signaling	R-HSA-8854691	9.666726e-01	0.015
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	9.666726e-01	0.015
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.666726e-01	0.015
Mitochondrial mRNA modification	R-HSA-9937008	9.666726e-01	0.015
Carnitine shuttle	R-HSA-200425	9.666726e-01	0.015
Formation of the ureteric bud	R-HSA-9830674	9.666726e-01	0.015
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.679986e-01	0.014
Hedgehog ligand biogenesis	R-HSA-5358346	9.685914e-01	0.014
Insulin receptor signalling cascade	R-HSA-74751	9.688192e-01	0.014
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.697284e-01	0.013
Antigen processing-Cross presentation	R-HSA-1236975	9.698847e-01	0.013
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.703642e-01	0.013
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	9.703642e-01	0.013
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.703642e-01	0.013
TNFs bind their physiological receptors	R-HSA-5669034	9.703642e-01	0.013
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.710135e-01	0.013
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	9.710135e-01	0.013
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.710135e-01	0.013
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.710135e-01	0.013
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.712532e-01	0.013
Interleukin-10 signaling	R-HSA-6783783	9.724769e-01	0.012
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.735143e-01	0.012
PI-3K cascade:FGFR2	R-HSA-5654695	9.736471e-01	0.012
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	9.736471e-01	0.012
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.736471e-01	0.012
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.736471e-01	0.012
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.736471e-01	0.012
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.736471e-01	0.012
Transmission across Chemical Synapses	R-HSA-112315	9.737350e-01	0.012
Diseases of Immune System	R-HSA-5260271	9.737533e-01	0.012
Diseases associated with the TLR signaling cascade	R-HSA-5602358	9.737533e-01	0.012
rRNA processing	R-HSA-72312	9.744158e-01	0.011
Interferon Signaling	R-HSA-913531	9.750067e-01	0.011
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.750067e-01	0.011
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.765666e-01	0.010
Urea cycle	R-HSA-70635	9.765666e-01	0.010
Sphingolipid catabolism	R-HSA-9845614	9.765666e-01	0.010
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.785016e-01	0.009
Cobalamin (Cbl) metabolism	R-HSA-9759218	9.791627e-01	0.009
Signaling by FGFR3 in disease	R-HSA-5655332	9.791627e-01	0.009
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.791627e-01	0.009
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.791627e-01	0.009
Signaling by BMP	R-HSA-201451	9.791627e-01	0.009
CD28 dependent PI3K/Akt signaling	R-HSA-389357	9.791627e-01	0.009
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.791627e-01	0.009
Synthesis of PE	R-HSA-1483213	9.791627e-01	0.009
Neutrophil degranulation	R-HSA-6798695	9.792821e-01	0.009
Signaling by Insulin receptor	R-HSA-74752	9.793355e-01	0.009
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.793355e-01	0.009
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.793355e-01	0.009
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.799088e-01	0.009
Activation of GABAB receptors	R-HSA-991365	9.805524e-01	0.009
GABA B receptor activation	R-HSA-977444	9.805524e-01	0.009
Activation of AMPK downstream of NMDARs	R-HSA-9619483	9.814714e-01	0.008
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.814714e-01	0.008
Iron assimilation using enterobactin	R-HSA-9638334	9.814714e-01	0.008
IRS-mediated signalling	R-HSA-112399	9.816475e-01	0.008
PPARA activates gene expression	R-HSA-1989781	9.817897e-01	0.008
Collagen formation	R-HSA-1474290	9.821805e-01	0.008
Thyroxine biosynthesis	R-HSA-209968	9.835244e-01	0.007
Proteasome assembly	R-HSA-9907900	9.840998e-01	0.007
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.840998e-01	0.007
Surfactant metabolism	R-HSA-5683826	9.840998e-01	0.007
Developmental Cell Lineages	R-HSA-9734767	9.843089e-01	0.007
Peroxisomal protein import	R-HSA-9033241	9.847030e-01	0.007
Amino acid transport across the plasma membrane	R-HSA-352230	9.847030e-01	0.007
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.852558e-01	0.006
Neurotransmitter clearance	R-HSA-112311	9.853500e-01	0.006
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.853500e-01	0.006
Transport to the Golgi and subsequent modification	R-HSA-948021	9.856523e-01	0.006
Metabolism of polyamines	R-HSA-351202	9.860416e-01	0.006
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.863854e-01	0.006
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.864174e-01	0.006
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.869734e-01	0.006
Molecules associated with elastic fibres	R-HSA-2129379	9.869734e-01	0.006
Regulation of pyruvate metabolism	R-HSA-9861718	9.870147e-01	0.006
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.870147e-01	0.006
G alpha (s) signalling events	R-HSA-418555	9.871504e-01	0.006
IRS-related events triggered by IGF1R	R-HSA-2428928	9.872674e-01	0.006
Post-translational protein phosphorylation	R-HSA-8957275	9.877732e-01	0.005
Cardiac conduction	R-HSA-5576891	9.891954e-01	0.005
ABC-family proteins mediated transport	R-HSA-382556	9.895087e-01	0.005
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.897008e-01	0.004
Recycling of bile acids and salts	R-HSA-159418	9.897008e-01	0.004
FCERI mediated MAPK activation	R-HSA-2871796	9.899569e-01	0.004
Integrin cell surface interactions	R-HSA-216083	9.903715e-01	0.004
Neuronal System	R-HSA-112316	9.907215e-01	0.004
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.908423e-01	0.004
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.913661e-01	0.004
Gap junction assembly	R-HSA-190861	9.918573e-01	0.004
eNOS activation	R-HSA-203615	9.918573e-01	0.004
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.918573e-01	0.004
RA biosynthesis pathway	R-HSA-5365859	9.918573e-01	0.004
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.918573e-01	0.004
Cytosolic sulfonation of small molecules	R-HSA-156584	9.922082e-01	0.003
The phototransduction cascade	R-HSA-2514856	9.922082e-01	0.003
SLC-mediated transport of amino acids	R-HSA-9958863	9.927132e-01	0.003
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.927599e-01	0.003
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.928922e-01	0.003
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.930770e-01	0.003
Triglyceride catabolism	R-HSA-163560	9.935625e-01	0.003
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.935625e-01	0.003
Regulation of PTEN stability and activity	R-HSA-8948751	9.936584e-01	0.003
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.937750e-01	0.003
Platelet homeostasis	R-HSA-418346	9.939225e-01	0.003
Immune System	R-HSA-168256	9.940739e-01	0.003
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.942762e-01	0.002
Collagen chain trimerization	R-HSA-8948216	9.942762e-01	0.002
Metabolism of folate and pterines	R-HSA-196757	9.942762e-01	0.002
COPII-mediated vesicle transport	R-HSA-204005	9.945092e-01	0.002
ECM proteoglycans	R-HSA-3000178	9.950062e-01	0.002
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.954594e-01	0.002
Pentose phosphate pathway	R-HSA-71336	9.954750e-01	0.002
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.954750e-01	0.002
Synthesis of PA	R-HSA-1483166	9.958098e-01	0.002
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.959767e-01	0.002
Tryptophan catabolism	R-HSA-71240	9.959767e-01	0.002
ROS and RNS production in phagocytes	R-HSA-1222556	9.962490e-01	0.002
Infectious disease	R-HSA-5663205	9.963799e-01	0.002
Iron uptake and transport	R-HSA-917937	9.965919e-01	0.001
ER-Phagosome pathway	R-HSA-1236974	9.966610e-01	0.001
Scavenging by Class A Receptors	R-HSA-3000480	9.968195e-01	0.001
GABA receptor activation	R-HSA-977443	9.969354e-01	0.001
Neurotransmitter release cycle	R-HSA-112310	9.969486e-01	0.001
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.970514e-01	0.001
Cytosolic tRNA aminoacylation	R-HSA-379716	9.971722e-01	0.001
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.971722e-01	0.001
Nucleotide salvage	R-HSA-8956321	9.972399e-01	0.001
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.972484e-01	0.001
ABC transporter disorders	R-HSA-5619084	9.974475e-01	0.001
Cholesterol biosynthesis	R-HSA-191273	9.974475e-01	0.001
Neddylation	R-HSA-8951664	9.977317e-01	0.001
Selenoamino acid metabolism	R-HSA-2408522	9.978243e-01	0.001
FCGR activation	R-HSA-2029481	9.978770e-01	0.001
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.978924e-01	0.001
Disease	R-HSA-1643685	9.980030e-01	0.001
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.980126e-01	0.001
SLC transporter disorders	R-HSA-5619102	9.982476e-01	0.001
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.984291e-01	0.001
Potassium Channels	R-HSA-1296071	9.985286e-01	0.001
G alpha (q) signalling events	R-HSA-416476	9.986564e-01	0.001
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.987583e-01	0.001
Chemokine receptors bind chemokines	R-HSA-380108	9.987583e-01	0.001
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.989316e-01	0.000
Leishmania parasite growth and survival	R-HSA-9664433	9.989506e-01	0.000
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.989506e-01	0.000
Complex IV assembly	R-HSA-9864848	9.990186e-01	0.000
Metal ion assimilation from the host	R-HSA-9638482	9.990393e-01	0.000
Pyruvate metabolism	R-HSA-70268	9.990397e-01	0.000
Diseases of carbohydrate metabolism	R-HSA-5663084	9.992234e-01	0.000
Class B/2 (Secretin family receptors)	R-HSA-373080	9.992865e-01	0.000
Paracetamol ADME	R-HSA-9753281	9.993869e-01	0.000
Metabolism of amine-derived hormones	R-HSA-209776	9.994550e-01	0.000
FCERI mediated NF-kB activation	R-HSA-2871837	9.994981e-01	0.000
Dectin-2 family	R-HSA-5621480	9.995155e-01	0.000
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.995575e-01	0.000
Mitochondrial protein degradation	R-HSA-9837999	9.995667e-01	0.000
Phospholipid metabolism	R-HSA-1483257	9.996014e-01	0.000
Triglyceride metabolism	R-HSA-8979227	9.996171e-01	0.000
tRNA Aminoacylation	R-HSA-379724	9.996596e-01	0.000
Signaling by Retinoic Acid	R-HSA-5362517	9.996596e-01	0.000
Mitochondrial translation elongation	R-HSA-5389840	9.996794e-01	0.000
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.996794e-01	0.000
Collagen degradation	R-HSA-1442490	9.996974e-01	0.000
Complex I biogenesis	R-HSA-6799198	9.997608e-01	0.000
CD22 mediated BCR regulation	R-HSA-5690714	9.997874e-01	0.000
tRNA processing	R-HSA-72306	9.998330e-01	0.000
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.998507e-01	0.000
Nicotinate metabolism	R-HSA-196807	9.998507e-01	0.000
Degradation of the extracellular matrix	R-HSA-1474228	9.998654e-01	0.000
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.998672e-01	0.000
Metabolism of cofactors	R-HSA-8978934	9.999068e-01	0.000
Retinoid metabolism and transport	R-HSA-975634	9.999068e-01	0.000
Post-translational protein modification	R-HSA-597592	9.999216e-01	0.000
Keratinization	R-HSA-6805567	9.999244e-01	0.000
Innate Immune System	R-HSA-168249	9.999248e-01	0.000
Aspirin ADME	R-HSA-9749641	9.999263e-01	0.000
Regulation of Complement cascade	R-HSA-977606	9.999300e-01	0.000
Bile acid and bile salt metabolism	R-HSA-194068	9.999303e-01	0.000
Disorders of transmembrane transporters	R-HSA-5619115	9.999325e-01	0.000
Translation	R-HSA-72766	9.999407e-01	0.000
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999418e-01	0.000
SLC-mediated transport of organic anions	R-HSA-9955298	9.999591e-01	0.000
Mitochondrial translation initiation	R-HSA-5368286	9.999624e-01	0.000
Interferon alpha/beta signaling	R-HSA-909733	9.999661e-01	0.000
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999661e-01	0.000
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999661e-01	0.000
Synthesis of bile acids and bile salts	R-HSA-192105	9.999663e-01	0.000
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.999713e-01	0.000
Peptide hormone metabolism	R-HSA-2980736	9.999725e-01	0.000
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999782e-01	0.000
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999796e-01	0.000
Peroxisomal lipid metabolism	R-HSA-390918	9.999798e-01	0.000
Cell surface interactions at the vascular wall	R-HSA-202733	9.999815e-01	0.000
G alpha (i) signalling events	R-HSA-418594	9.999880e-01	0.000
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999888e-01	0.000
Mitochondrial translation termination	R-HSA-5419276	9.999899e-01	0.000
Complement cascade	R-HSA-166658	9.999936e-01	0.000
Extracellular matrix organization	R-HSA-1474244	9.999941e-01	0.000
Scavenging of heme from plasma	R-HSA-2168880	9.999961e-01	0.000
Bacterial Infection Pathways	R-HSA-9824439	9.999970e-01	0.000
GPCR downstream signalling	R-HSA-388396	9.999973e-01	0.000
Mitochondrial translation	R-HSA-5368287	9.999978e-01	0.000
Metabolism of steroids	R-HSA-8957322	9.999987e-01	0.000
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999988e-01	0.000
Visual phototransduction	R-HSA-2187338	9.999992e-01	0.000
Sphingolipid metabolism	R-HSA-428157	9.999993e-01	0.000
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999994e-01	0.000
Antimicrobial peptides	R-HSA-6803157	9.999995e-01	0.000
Arachidonate metabolism	R-HSA-2142753	9.999996e-01	0.000
Asparagine N-linked glycosylation	R-HSA-446203	9.999997e-01	0.000
Respiratory electron transport	R-HSA-611105	9.999998e-01	0.000
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999998e-01	0.000
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999999e-01	0.000
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000
Diseases of glycosylation	R-HSA-3781865	1.000000e+00	0.000
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000
Drug ADME	R-HSA-9748784	1.000000e+00	0.000
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000
Metabolism	R-HSA-1430728	1.000000e+00	-0.000
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000