SKMLCK

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0MZ66 S473 Sugiyama SHTN1 KIAA1598 LGtLNKSTSSRsLKsLDPENsEtELERILRRRKVtAEADss
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
O00512 S104 Sugiyama BCL9 GLKNGAGNGAKGKGKRERsIsADsFDQRDPGtPNDDsDIKE
O14639 S452 Sugiyama ABLIM1 ABLIM KIAA0059 LIMAB1 PtPsAEGyQDVRDRMIHRstsQGsINsPVySRHsYtPTTSR
O14950 S20 GPS6 MYL12B MRLC2 MYLC2B _MSSKKAKTKTTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
O14950 T19 GPS6 MYL12B MRLC2 MYLC2B __MSSKKAKTKTTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
O14974 S695 Sugiyama PPP1R12A MBS MYPT1 DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974 T141 GPS6 PPP1R12A MBS MYPT1 IAEFLIGQGAHVGAVNSEGDtPLDIAEEEAMEELLQNEVNR
O14974 T696 Sugiyama PPP1R12A MBS MYPT1 EEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRS
O14974 T700 Sugiyama PPP1R12A MBS MYPT1 sQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSRSTRTR
O15212 T107 Sugiyama PFDN6 HKE2 PFD6 IKRYESQLRDLERQsEQQREtLAQLQQEFQRAQAAKAGAPG
O43707 T443 Sugiyama ACTN4 sIHEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDL
O43707 T445 Sugiyama ACTN4 HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O43823 S323 Sugiyama AKAP8 AKAP95 RKRKQFQLyEEPDtKLARVDsEGDFsENDDAAGDFRsGDEE
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O60749 S119 Sugiyama SNX2 TRG9 AVtPVtPttLIAPRIESKsMsAPVIFDRsREEIEEEANGDI
O60814 S39 Sugiyama H2BC12 H2BFT HIRIP1 HIST1H2BK VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
O75128 S1174 Sugiyama COBL KIAA0633 LAAIRGHSGTCSLRKVAsSAsEELQSFRDAALSAQGSESPL
O76021 S92 Sugiyama RSL1D1 CATX11 CSIG PBK1 L12 KIPSKELRVRLTLPHSIRsDsEDICLFTKDEPNStPEKTEQ
O95714 S2928 Sugiyama HERC2 ILLGRIRAEEEDLAAVPFLAsDNEEEEDEKGNSGsLIRKKA
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 T322 Sugiyama LDHA PIG19 DLVKVTLtsEEEARLKKsADtLWGIQKELQF__________
P00491 S176 Sugiyama PNP NP GDRFPAMsDAyDRtMRQRALstWKQMGEQRELQEGTYVMVA
P00558 S174 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 LSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKEL
P00558 S175 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 SKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGFLMKKELN
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04181 T39 Sugiyama OAT HSSVASATSVATKKtVQGPPtSDDIFEREyKyGAHNyHPLP
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T237 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 VGKVIPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDD
P04792 S78 Sugiyama HSPB1 HSP27 HSP28 LPPAAIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVs
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05455 S94 Sugiyama SSB KSKAELMEIsEDKTKIRRsPsKPLPEVTDEyKNDVKNRsVY
P06733 T19 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 __MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGA
P06744 T109 Sugiyama GPI KINyTEGRAVLHVALRNRsNtPILVDGKDVMPEVNKVLDKM
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900 S505 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA KENQKHIyyItGETKDQVANsAFVERLRKHGLEVIyMIEPI
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S452 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AFSKNLKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEy
P08238 S460 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S497 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 Y457 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P08670 T327 Sugiyama VIM DALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMREM
P09972 S45 Sugiyama ALDOC ALDC APGKGILAADEsVGsMAKRLsQIGVENtEENRRLYRQVLFs
P0CG47 S57 Sugiyama UBB PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P0CG48 S57 Sugiyama UBC PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGM
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P13073 S71 Sugiyama COX4I1 COX4 HVKHLSASQKALKEKEKASWssLsMDEKVELYRIKFKEsFA
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S172 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14866 S544 Sugiyama HNRNPL HNRPL P/OKcl.14 LGVKRPSSVKVFSGKsERsssGLLEWEsKSDALETLGFLNH
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17544 S44 Sugiyama ATF7 ATFA LAVHKHKHEMTLKFGPARtDsVIIADQtPtPtRFLKNCEEV
P17987 S374 Sugiyama TCP1 CCT1 CCTA ERICDDELILIKNTKARTsAsIILRGANDFMCDEMERSLHD
P18615 S51 Sugiyama NELFE RD RDBP ALKKQSSSSTTSQGGVKRsLsEQPVMDTATATEQAKQLVKS
P18621 S5 Sugiyama RPL17 ________________MVRysLDPENPtKsCKSRGSNLRVH
P19105 T18 GPS6 MYL12A MLCB MRLC3 RLC ___MSSKRTKTKTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 Y463 Sugiyama NCL EKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWsG
P22626 S189 Sugiyama HNRNPA2B1 HNRPA2B1 IVLQKyHtINGHNAEVRKALsRQEMQEVQssRsGRGGNFGF
P22626 S225 Sugiyama HNRNPA2B1 HNRPA2B1 GNFGFGDsRGGGGNFGPGPGsNFRGGsDGyGsGRGFGDGyN
P24534 S141 Sugiyama EEF1B2 EEF1B EF1B ERLAQYESKKAKKPALVAKssILLDVKPWDDEtDMAKLEEC
P24844 S20 GPS6 MYL9 MLC2 MRLC1 MYRL2 _MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P24844 T19 GPS6 MYL9 MLC2 MRLC1 MYRL2 __MssKRAKAKtTKKRPQRAtsNVFAMFDQSQIQEFKEAFN
P25789 T10 Sugiyama PSMA4 HC9 PSC9 ___________MSRRyDsRttIFsPEGRLYQVEYAMEAIGH
P25789 T9 Sugiyama PSMA4 HC9 PSC9 ____________MSRRyDsRttIFsPEGRLYQVEYAMEAIG
P26038 T526 Sugiyama MSN EERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHA
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P31327 T45 Sugiyama CPS1 AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P32119 T142 Sugiyama PRDX2 NKEFB TDPX1 EGIAYRGLFIIDGKGVLRQItVNDLPVGRsVDEALRLVQAF
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P35241 S532 Sugiyama RDX EERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHA
P35241 S533 Sugiyama RDX ERVTETQKNERVKKQLQALssELAQARDETKKTQNDVLHAE
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P40337 S72 Sugiyama VHL EEMEAGRPRPVLRSVNsREPsQVIFCNRsPRVVLPVWLNFD
P40818 S719 Sugiyama USP8 KIAA0055 UBPY KPQIPAERDREPSKLKRsyssPDItQAIQEEEKRKPTVtPT
P40939 T418 Sugiyama HADHA HADH DRGQQQVFKGLNDKVKKKALtSFERDSIFSNLTGQLDyQGF
P41236 T22 Sugiyama PPP1R2 IPP2 AASTAsHRPIKGILKNKtsttssMVAsAEQPRGNVDEELSK
P43034 S152 Sugiyama PAFAH1B1 LIS1 MDCR MDS PAFAHA IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM
P43243 S188 Sugiyama MATR3 KIAA0723 EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P46013 S1098 Sugiyama MKI67 PAARVTGMKKWPRtPKEEAQsLEDLAGFKELFQtPGPsEEs
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783 S146 Sugiyama RPS10 TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46937 S109 Sugiyama YAP1 YAP65 RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P47712 S727 Sugiyama PLA2G4A CPLA2 PLA2G4 VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49321 S659 Sugiyama NASP IEELKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsst
P49321 S662 Sugiyama NASP LKELLPEIREKIEDAKEsQRsGNVAELALKATLVEsstsGF
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49736 S229 Sugiyama MCM2 BM28 CCNL1 CDCL1 KIAA0030 sHGHNVFKERIsDMCKENREsLVVNyEDLAAREHVLAYFLP
P50395 S396 Sugiyama GDI2 RABGDIB IEQKFVsISDLLVPKDLGtEsQIFIsRTyDAttHFEttCDD
P50395 T413 Sugiyama GDI2 RABGDIB GtEsQIFIsRTyDAttHFEttCDDIKNIYKRMtGsEFDFEE
P52298 S13 Sugiyama NCBP2 CBP20 PIG55 ________MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQE
P52298 Y14 Sugiyama NCBP2 CBP20 PIG55 _______MSGGLLKALRsDsyVELSQYRDQHFRGDNEEQEK
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P55010 S10 Sugiyama EIF5 ___________MSVNVNRsVsDQFyRyKMPRLIAKVEGKGN
P57053 S39 Sugiyama H2BC12L H2BFS H2BS1 VTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P58876 S39 Sugiyama H2BC5 H2BFB HIRIP2 HIST1H2BD VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
P60174 T38 Sugiyama TPI1 TPI RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60900 S175 Sugiyama PSMA6 PROS27 DPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTV
P60900 T173 Sugiyama PSMA6 PROS27 KCDPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQ
P61353 S86 Sugiyama RPL27 SKIKSFVKVyNyNHLMPtRysVDIPLDKtVVNKDVFRDPAL
P61978 S417 Sugiyama HNRNPK HNRPK DLAGsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITI
P61978 S420 Sugiyama HNRNPK HNRPK GsIIGKGGQRIKQIRHEsGAsIKIDEPLEGsEDRIITItGt
P62269 S96 Sugiyama RPS18 D6S218E QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277 S12 Sugiyama RPS13 _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62316 T40 Sugiyama SNRPD2 SNRPD1 EEEEFNtGPLsVLtQsVKNNtQVLINCRNNKKLLGRVKAFD
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62424 T93 Sugiyama RPL7A SURF-3 SURF3 RLKVPPAINQFtQALDRQTAtQLLKLAHKYRPEtKQEKKQR
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62807 S39 Sugiyama H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI VTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIssKA
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 S64 Sugiyama RPL10A NEDD6 QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62979 S57 Sugiyama RPS27A UBA80 UBCEP1 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGA
P62987 S57 Sugiyama UBA52 UBCEP2 PPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRGGI
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809 S209 Sugiyama YBX1 NSEP1 YB1 RRRRFPPyyMRRPYGRRPQysNPPVQGEVMEGADNQGAGEQ
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P78345 S253 Sugiyama RPP38 DtsFEDLsKPKRKLADGRQAsVtLQPLKIKKLIPNPNKIRK
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
Q00839 Y257 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 QKGGDKKRGVKRPREDHGRGyFEyIEENKysRAKsPQPPVE
Q01082 S1388 Sugiyama SPTBN1 SPTB2 TTQTKAQRLFDANKAELFtQsCADLDKWLHGLESQIQSDDy
Q01082 S2184 Sugiyama SPTBN1 SPTB2 ssPIPsPtsDRKAKTALPAQsAAtLPARtQEtPsAQMEGFL
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q02543 S123 Sugiyama RPL18A AGAVtQCyRDMGARHRARAHsIQIMKVEEIAASKCRRPAVK
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06210 S261 Sugiyama GFPT1 GFAT GFPT GsQGERGKDKKGSCNLsRVDsttCLFPVEEKAVEyyFASDA
Q06413 T80 SIGNOR|EPSD|PSP MEF2C TDMDKVLLKYTEYNEPHESRtNSDIVETLRKKGLNGCDsPD
Q06830 T143 Sugiyama PRDX1 PAGA PAGB TDPX2 EGIsFRGLFIIDDKGILRQItVNDLPVGRsVDEtLRLVQAF
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07021 S106 Sugiyama C1QBP GC1QBP HABP1 SF2P32 LsDEIKEERKIQKHKTLPKMsGGWELELNGTEAKLVRKVAG
Q08AD1 S1313 Sugiyama CAMSAP2 CAMSAP1L1 KIAA1078 sLNtGDNEsVHsGKRtPRsEsVEGFLsPsRCGsRNGEKDWE
Q09028 S146 Sugiyama RBBP4 RBAP48 EVNRARYMPQNPCIIATKtPssDVLVFDyTKHPsKPDPsGE
Q12965 T935 Sugiyama MYO1E MYO1C VLQVSIGPGLPKNSRPTRRNttQNtGySsGtQNANyPVRAA
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13769 S312 Sugiyama THOC5 C22orf19 KIAA0983 GSVDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQ
Q13769 S314 Sugiyama THOC5 C22orf19 KIAA0983 VDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQLD
Q14247 S113 Sugiyama CTTN EMS1 DRMDKsAVGHEyQSKLsKHCsQVDsVRGFGGKFGVQMDRVD
Q14432 S312 Sugiyama PDE3A sssVVsAEMSGCSSKSHRRtsLPCIPREQLMGHSEWDHKRG
Q14498 S336 Sugiyama RBM39 HCC1 RNPC2 LAGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGR
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q15185 S85 Sugiyama PTGES3 P23 TEBP KHKRtDRsILCCLRKGEsGQsWPRLTKERAKLNWLsVDFNN
Q16576 S145 Sugiyama RBBP7 RBAP46 EVNRARYMPQNPHIIATKtPssDVLVFDyTKHPAKPDPsGE
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 S370 Sugiyama HSP90AB3P HSP90BC KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q5QNW6 S39 Sugiyama H2BC18 HIST2H2BF VTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q5SSJ5 S225 Sugiyama HP1BP3 QALKRELNRGVIKQVKGKGAsGsFVVVQKSRKTPQKSRNRK
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6PID6 S19 Sugiyama TTC33 __MASFGWKRKIGEKVSKVTsQQFEAEAADEKDVVDNDEGN
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q86V81 S239 Sugiyama ALYREF ALY BEF THOC4 tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__
Q86VQ1 S223 Sugiyama GLCCI1 QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q92766 S1167 Sugiyama RREB1 FINB AGTSKKRGRKRGMRSRPRANsGGVDLDssGEFASIEKMLAT
Q93079 S39 Sugiyama H2BC9 H2BFJ HIST1H2BH VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q96IZ0 S162 Sugiyama PAWR PAR4 PSARKGKGQIEKRKLREKRRstGVVNIPAAECLDEyEDDEA
Q96IZ0 T163 Sugiyama PAWR PAR4 SARKGKGQIEKRKLREKRRstGVVNIPAAECLDEyEDDEAG
Q96L92 S51 Sugiyama SNX27 KIAA0488 My014 AGNGGGGGGGPRVVRIVKsEsGYGFNVRGQVsEGGQLRSIN
Q99848 S264 Sugiyama EBNA1BP2 EBP2 KNQKFGFGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRP
Q99877 S39 Sugiyama H2BC15 H2BFD HIST1H2BN VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99879 S39 Sugiyama H2BC14 H2BFE HIST1H2BM INKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q99880 S39 Sugiyama H2BC13 H2BFC HIST1H2BL VTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIssKA
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9H173 T125 Sugiyama SIL1 UNQ545/PRO836 QYEDKFRNNLKGKRLDINtNtytsQDLKSALAKFKEGAEME
Q9H1R3 S107 Sugiyama MYLK2 AEGsAGPPAALPQQTAtPETsVKKPKAEQGASGsQDPGKPR
Q9H1R3 S143 Sugiyama MYLK2 PGKPRVGKKAAEGQAAARRGsPAFLHsPsCPAIISssEKLL
Q9H1R3 S149 Sugiyama MYLK2 GKKAAEGQAAARRGsPAFLHsPsCPAIISssEKLLAKKPPS
Q9H1R3 S151 Sugiyama MYLK2 KAAEGQAAARRGsPAFLHsPsCPAIISssEKLLAKKPPSEA
Q9H1R3 S158 Sugiyama MYLK2 AARRGsPAFLHsPsCPAIISssEKLLAKKPPSEASELtFEG
Q9H1R3 S159 Sugiyama MYLK2 ARRGsPAFLHsPsCPAIISssEKLLAKKPPSEASELtFEGV
Q9H1R3 S203 Sugiyama MYLK2 HsPtDPRPAKAEEGKNILAEsQKEVGEKtPGQAGQAKMQGD
Q9H1R3 S225 Sugiyama MYLK2 KEVGEKtPGQAGQAKMQGDtsRGIEFQAVPSEKSEVGQALC
Q9H1R3 S280 Sugiyama MYLK2 CPPPPAPFPHRMVELRTGNVsSEFSMNsKEALGGGKFGAVC
Q9H1R3 S287 Sugiyama MYLK2 FPHRMVELRTGNVsSEFSMNsKEALGGGKFGAVCTCMEKAT
Q9H1R3 S577 Sugiyama MYLK2 QILLKKYLMKRRWKKNFIAVsAANRFKKIsssGALMALGV_
Q9H1R3 S586 Sugiyama MYLK2 KRRWKKNFIAVsAANRFKKIsssGALMALGV__________
Q9H1R3 S587 Sugiyama MYLK2 RRWKKNFIAVsAANRFKKIsssGALMALGV___________
Q9H1R3 S59 Sugiyama MYLK2 PDPKKAPDPPTLKKDAKAPAsEKGDGTLAQPSTssQGPKGE
Q9H1R3 S72 Sugiyama MYLK2 KDAKAPAsEKGDGTLAQPSTssQGPKGEGDRGGGPAEGsAG
Q9H1R3 S73 Sugiyama MYLK2 DAKAPAsEKGDGTLAQPSTssQGPKGEGDRGGGPAEGsAGP
Q9H1R3 S90 Sugiyama MYLK2 STssQGPKGEGDRGGGPAEGsAGPPAALPQQTAtPETsVKK
Q9H1R3 T103 Sugiyama MYLK2 GGGPAEGsAGPPAALPQQTAtPETsVKKPKAEQGASGsQDP
Q9H1R3 T175 Sugiyama MYLK2 IISssEKLLAKKPPSEASELtFEGVPMtHsPtDPRPAKAEE
Q9H1R3 T182 Sugiyama MYLK2 LLAKKPPSEASELtFEGVPMtHsPtDPRPAKAEEGKNILAE
Q9H1R3 T211 Sugiyama MYLK2 AKAEEGKNILAEsQKEVGEKtPGQAGQAKMQGDtsRGIEFQ
Q9H1R3 T224 Sugiyama MYLK2 QKEVGEKtPGQAGQAKMQGDtsRGIEFQAVPSEKSEVGQAL
Q9H788 S315 Sugiyama SH2D4A PPP1R38 SH2A LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9NQ39 S157 Sugiyama RPS10P5 RPS10L TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NQZ2 S462 Sugiyama UTP3 CRLZ1 SAS10 RAKIRRRGQVREVRKEEQRYsGELsGIRAGVKKSIKLK___
Q9NUU7 T467 Sugiyama DDX19A DDX19L SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UBP6 S27 Sugiyama METTL1 C12orf1 NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UJU6 T270 Sugiyama DBNL CMAP SH3P7 PP5423 EQESAVHPREIFKQKERAMsttsIssPQPGKLRsPFLQKQL
Q9UMR2 T468 Sugiyama DDX19B DBP5 DDX19 TDBP SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UQ35 S1103 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 sPsLQSKSQTsPKGGRsRsssPVtELAsRsPIRQDRGEFsA
Q9UQ35 S2692 Sugiyama SRRM2 KIAA0324 SRL300 SRM300 HSPC075 ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9UQ80 T377 Sugiyama PA2G4 EBP1 LLQssAsRKtQKKKKKKAsKtAENAtsGEtLEENEAGD___
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0 S116 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2T7 T143 Sugiyama YBX2 CSDA3 MSY2 QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 6.923803e-08 7.160 0 0
Cell Cycle Checkpoints R-HSA-69620 6.393719e-07 6.194 0 0
Cell Cycle, Mitotic R-HSA-69278 8.368556e-07 6.077 0 0
Apoptotic execution phase R-HSA-75153 1.483500e-06 5.829 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.635684e-06 5.579 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.118801e-06 5.506 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.118801e-06 5.506 0 0
Signal Transduction R-HSA-162582 3.545498e-06 5.450 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.467356e-06 5.460 0 0
Signaling by Hippo R-HSA-2028269 4.697484e-06 5.328 0 0
G alpha (12/13) signalling events R-HSA-416482 2.447034e-05 4.611 0 0
NRAGE signals death through JNK R-HSA-193648 2.344630e-05 4.630 0 0
Mitotic Prometaphase R-HSA-68877 3.817437e-05 4.418 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 6.037542e-05 4.219 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.244873e-05 4.084 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.251387e-04 3.903 0 0
HSF1-dependent transactivation R-HSA-3371571 1.483868e-04 3.829 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.509335e-04 3.821 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.646212e-04 3.784 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.232962e-04 3.490 0 0
M Phase R-HSA-68886 3.448659e-04 3.462 0 0
Membrane Trafficking R-HSA-199991 3.923502e-04 3.406 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.808313e-04 3.236 0 0
Cellular response to heat stress R-HSA-3371556 5.954107e-04 3.225 0 0
Separation of Sister Chromatids R-HSA-2467813 5.473485e-04 3.262 0 0
Axon guidance R-HSA-422475 5.805946e-04 3.236 0 0
Nervous system development R-HSA-9675108 5.970199e-04 3.224 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.356901e-04 3.197 0 0
Regulation of TP53 Activity R-HSA-5633007 6.371616e-04 3.196 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.211097e-04 3.142 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 7.211097e-04 3.142 0 0
Mitotic Anaphase R-HSA-68882 8.474086e-04 3.072 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 9.278331e-04 3.033 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.098752e-03 2.959 0 0
Attenuation phase R-HSA-3371568 1.348737e-03 2.870 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.845048e-03 2.734 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.184582e-03 2.661 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.184582e-03 2.661 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.184582e-03 2.661 0 0
Signaling by RAS mutants R-HSA-6802949 2.184582e-03 2.661 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.537670e-03 2.596 0 0
Regulation of TP53 Expression R-HSA-6804754 2.668444e-03 2.574 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 2.799920e-03 2.553 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.747327e-03 2.561 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.810633e-03 2.551 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.593437e-03 2.444 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.642517e-03 2.439 0 0
HSF1 activation R-HSA-3371511 3.835634e-03 2.416 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.307124e-03 2.366 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.665052e-03 2.331 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.677742e-03 2.330 0 0
Kinesins R-HSA-983189 4.506326e-03 2.346 0 0
Signaling by ROBO receptors R-HSA-376176 4.739980e-03 2.324 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.924019e-03 2.308 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.946241e-03 2.306 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.280477e-03 2.277 0 0
Death Receptor Signaling R-HSA-73887 5.416762e-03 2.266 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.949953e-03 2.225 0 0
MTOR signalling R-HSA-165159 5.875035e-03 2.231 0 0
Activation of RAC1 R-HSA-428540 5.980301e-03 2.223 0 0
Oncogenic MAPK signaling R-HSA-6802957 7.986011e-03 2.098 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.752360e-03 2.111 0 0
S Phase R-HSA-69242 8.674783e-03 2.062 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.303647e-03 2.081 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 8.346416e-03 2.078 0 0
Diseases of mitotic cell cycle R-HSA-9675126 8.861650e-03 2.052 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 9.148360e-03 2.039 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.069079e-02 1.971 0 0
Apoptosis R-HSA-109581 1.064288e-02 1.973 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 1.085074e-02 1.965 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 1.085074e-02 1.965 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.133761e-02 1.945 0 0
MAP2K and MAPK activation R-HSA-5674135 1.123123e-02 1.950 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.105881e-02 1.956 0 0
Chromatin organization R-HSA-4839726 1.081614e-02 1.966 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.149065e-02 1.940 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.154790e-02 1.937 0 0
EPH-Ephrin signaling R-HSA-2682334 1.194101e-02 1.923 0 0
G2/M Transition R-HSA-69275 1.202577e-02 1.920 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.185817e-02 1.926 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.241651e-02 1.906 0 0
Signaling by ALK in cancer R-HSA-9700206 1.241651e-02 1.906 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.255860e-02 1.901 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.288480e-02 1.890 0 0
Chromatin modifying enzymes R-HSA-3247509 1.317048e-02 1.880 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 1.448205e-02 1.839 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.389578e-02 1.857 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.449386e-02 1.839 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.478020e-02 1.830 0 0
Interleukin-37 signaling R-HSA-9008059 1.478020e-02 1.830 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.491898e-02 1.826 0 0
Nuclear import of Rev protein R-HSA-180746 1.521006e-02 1.818 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.536434e-02 1.813 0 0
Centrosome maturation R-HSA-380287 1.625721e-02 1.789 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.584530e-02 1.800 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.625721e-02 1.789 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.767232e-02 1.753 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.767232e-02 1.753 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.794693e-02 1.746 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.795090e-02 1.746 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.952243e-02 1.709 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.978188e-02 1.704 0 0
mTORC1-mediated signalling R-HSA-166208 1.948667e-02 1.710 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.952243e-02 1.709 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.049463e-02 1.688 0 0
Type I hemidesmosome assembly R-HSA-446107 2.084447e-02 1.681 0 0
Signaling by EGFR R-HSA-177929 2.184373e-02 1.661 0 0
Germ layer formation at gastrulation R-HSA-9754189 2.215042e-02 1.655 0 0
Rap1 signalling R-HSA-392517 2.215042e-02 1.655 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.350066e-02 1.629 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.358757e-02 1.627 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.360519e-02 1.627 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.363252e-02 1.626 0 0
Integrin signaling R-HSA-354192 2.468946e-02 1.607 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.468946e-02 1.607 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.468946e-02 1.607 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 2.452023e-02 1.610 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.576182e-02 1.589 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.545398e-02 1.594 0 0
Prolonged ERK activation events R-HSA-169893 2.486769e-02 1.604 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.631048e-02 1.580 0 0
Semaphorin interactions R-HSA-373755 2.646778e-02 1.577 0 0
ALK mutants bind TKIs R-HSA-9700645 2.879697e-02 1.541 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.913715e-02 1.536 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.839707e-02 1.547 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.879697e-02 1.541 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.839707e-02 1.547 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.761166e-02 1.559 0 0
Signaling by VEGF R-HSA-194138 2.850304e-02 1.545 0 0
Neurodegenerative Diseases R-HSA-8863678 2.851925e-02 1.545 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.851925e-02 1.545 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.761166e-02 1.559 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.887147e-02 1.540 0 0
NGF-stimulated transcription R-HSA-9031628 3.042657e-02 1.517 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 3.066056e-02 1.513 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.286588e-02 1.483 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.286588e-02 1.483 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.286588e-02 1.483 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.286588e-02 1.483 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.286588e-02 1.483 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.398986e-02 1.469 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.398986e-02 1.469 0 0
RAF activation R-HSA-5673000 3.353810e-02 1.474 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.269930e-02 1.485 0 0
G2/M Checkpoints R-HSA-69481 3.321610e-02 1.479 0 0
HDMs demethylate histones R-HSA-3214842 3.398986e-02 1.469 0 0
PI Metabolism R-HSA-1483255 3.394541e-02 1.469 0 0
Signaling by ALK R-HSA-201556 3.269930e-02 1.485 0 0
Activation of the pre-replicative complex R-HSA-68962 3.402783e-02 1.468 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.402783e-02 1.468 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 3.506136e-02 1.455 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 3.506136e-02 1.455 0 0
Frs2-mediated activation R-HSA-170968 3.506136e-02 1.455 0 0
Netrin-1 signaling R-HSA-373752 3.599519e-02 1.444 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.669150e-02 1.435 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.744827e-02 1.427 0 0
Homology Directed Repair R-HSA-5693538 3.810569e-02 1.419 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.838738e-02 1.416 0 0
Specification of primordial germ cells R-HSA-9827857 3.838738e-02 1.416 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.844070e-02 1.415 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.844070e-02 1.415 0 0
EGFR downregulation R-HSA-182971 3.967191e-02 1.402 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.972349e-02 1.401 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.408584e-02 1.356 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.147726e-02 1.382 0 0
RUNX2 regulates bone development R-HSA-8941326 4.442095e-02 1.352 0 0
RET signaling R-HSA-8853659 4.442095e-02 1.352 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.443103e-02 1.352 0 0
Muscle contraction R-HSA-397014 4.549203e-02 1.342 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.592973e-02 1.338 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 4.597288e-02 1.337 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.636314e-02 1.334 0 0
Ephrin signaling R-HSA-3928664 4.666256e-02 1.331 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.690787e-02 1.329 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.789690e-02 1.320 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.789690e-02 1.320 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 5.391422e-02 1.268 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.391422e-02 1.268 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.441276e-02 1.264 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.441276e-02 1.264 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.983955e-02 1.302 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.983955e-02 1.302 0 0
mRNA 3'-end processing R-HSA-72187 4.873088e-02 1.312 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.443850e-02 1.264 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.443850e-02 1.264 0 0
Cell junction organization R-HSA-446728 5.343319e-02 1.272 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.067920e-02 1.295 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 5.461380e-02 1.263 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.599668e-02 1.252 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.750561e-02 1.240 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 6.752329e-02 1.171 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.302024e-02 1.201 0 0
Signaling by GSK3beta mutants R-HSA-5339716 6.302024e-02 1.201 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.614251e-02 1.180 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.641141e-02 1.178 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.641141e-02 1.178 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 6.641141e-02 1.178 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 6.641141e-02 1.178 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 6.641141e-02 1.178 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 6.641141e-02 1.178 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.260562e-02 1.203 0 0
HATs acetylate histones R-HSA-3214847 6.789974e-02 1.168 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.641141e-02 1.178 0 0
Mitotic Prophase R-HSA-68875 6.731693e-02 1.172 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.856307e-02 1.164 0 0
Breakdown of the nuclear lamina R-HSA-352238 6.752329e-02 1.171 0 0
Negative regulation of MET activity R-HSA-6807004 6.641141e-02 1.178 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.317242e-02 1.199 0 0
Cell-Cell communication R-HSA-1500931 6.956434e-02 1.158 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.614251e-02 1.180 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.856307e-02 1.164 0 0
Programmed Cell Death R-HSA-5357801 6.092526e-02 1.215 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 6.491420e-02 1.188 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 7.005081e-02 1.155 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.164396e-02 1.145 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.210552e-02 1.142 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.291581e-02 1.137 0 0
Glycolysis R-HSA-70171 7.302662e-02 1.137 0 0
TGFBR3 expression R-HSA-9839394 7.533989e-02 1.123 0 0
Tight junction interactions R-HSA-420029 7.533989e-02 1.123 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.533989e-02 1.123 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.629060e-02 1.118 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.629060e-02 1.118 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 7.745051e-02 1.111 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 7.745051e-02 1.111 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 7.745051e-02 1.111 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 7.745051e-02 1.111 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.797386e-02 1.108 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.797386e-02 1.108 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.797386e-02 1.108 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.797386e-02 1.108 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.797386e-02 1.108 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.093190e-02 1.092 0 0
FLT3 Signaling R-HSA-9607240 8.151798e-02 1.089 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.151798e-02 1.089 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.170044e-02 1.088 0 0
ARMS-mediated activation R-HSA-170984 9.131299e-02 1.039 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 9.131299e-02 1.039 0 0
snRNP Assembly R-HSA-191859 9.679417e-02 1.014 0 0
Metabolism of non-coding RNA R-HSA-194441 9.679417e-02 1.014 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.444435e-02 1.073 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.795774e-02 1.009 0 0
Signaling by FGFR1 in disease R-HSA-5655302 9.072480e-02 1.042 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 9.725203e-02 1.012 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 9.359928e-02 1.029 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 9.286581e-02 1.032 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.128219e-02 1.040 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 9.131299e-02 1.039 0 0
Interaction between L1 and Ankyrins R-HSA-445095 9.849840e-02 1.007 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.028612e-01 0.988 0 0
Signaling by NTRKs R-HSA-166520 1.034710e-01 0.985 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.041701e-01 0.982 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.041701e-01 0.982 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 1.041701e-01 0.982 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.046773e-01 0.980 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.046773e-01 0.980 0 0
mRNA Splicing R-HSA-72172 1.073522e-01 0.969 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.093028e-01 0.961 0 0
Polo-like kinase mediated events R-HSA-156711 1.093028e-01 0.961 0 0
Mismatch Repair R-HSA-5358508 1.093028e-01 0.961 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.093028e-01 0.961 0 0
Potassium transport channels R-HSA-1296067 1.097380e-01 0.960 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.125642e-01 0.949 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.312166e-01 0.882 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.312166e-01 0.882 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.312166e-01 0.882 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.312166e-01 0.882 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.452219e-01 0.610 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.452219e-01 0.610 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.452219e-01 0.610 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.452219e-01 0.610 0 0
Tandem pore domain halothane-inhibited K+ channel (THIK) R-HSA-1299287 2.452219e-01 0.610 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.569317e-01 0.804 0 0
MET interacts with TNS proteins R-HSA-8875513 1.569317e-01 0.804 0 0
Invadopodia formation R-HSA-8941237 1.569317e-01 0.804 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.350647e-01 0.869 0 0
Regulation of gap junction activity R-HSA-191650 2.070722e-01 0.684 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.070722e-01 0.684 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 2.070722e-01 0.684 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 2.070722e-01 0.684 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.070722e-01 0.684 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.070722e-01 0.684 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.070722e-01 0.684 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.442728e-01 0.463 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 3.442728e-01 0.463 0 0
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome R-HSA-5678420 3.442728e-01 0.463 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 3.442728e-01 0.463 0 0
MyD88 deficiency (TLR5) R-HSA-5602680 3.442728e-01 0.463 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.442728e-01 0.463 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.442728e-01 0.463 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 3.442728e-01 0.463 0 0
Intestinal infectious diseases R-HSA-8942233 3.442728e-01 0.463 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 3.442728e-01 0.463 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.442728e-01 0.463 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.442728e-01 0.463 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.442728e-01 0.463 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.442728e-01 0.463 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 3.442728e-01 0.463 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.442728e-01 0.463 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.442728e-01 0.463 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.442728e-01 0.463 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.132600e-01 0.946 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.680476e-01 0.775 0 0
Signaling by APC mutants R-HSA-4839744 1.372820e-01 0.862 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.372820e-01 0.862 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.372820e-01 0.862 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.372820e-01 0.862 0 0
IRS activation R-HSA-74713 2.585744e-01 0.587 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.585744e-01 0.587 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.130026e-01 0.947 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 1.130026e-01 0.947 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.030587e-01 0.692 0 0
Formation of annular gap junctions R-HSA-196025 2.030587e-01 0.692 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.631451e-01 0.787 0 0
DCC mediated attractive signaling R-HSA-418885 1.329094e-01 0.876 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.329094e-01 0.876 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.329094e-01 0.876 0 0
Phosphorylation of the APC/C R-HSA-176412 1.542606e-01 0.812 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.542606e-01 0.812 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.905948e-01 0.720 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 1.905948e-01 0.720 0 0
Gap junction degradation R-HSA-190873 2.395513e-01 0.621 0 0
Synthesis of PS R-HSA-1483101 3.102184e-01 0.508 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.102184e-01 0.508 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.303300e-01 0.366 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.303300e-01 0.366 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.303300e-01 0.366 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 4.303300e-01 0.366 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.303300e-01 0.366 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 4.303300e-01 0.366 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.303300e-01 0.366 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.303300e-01 0.366 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.303300e-01 0.366 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.303300e-01 0.366 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.303300e-01 0.366 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 4.303300e-01 0.366 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.303300e-01 0.366 0 0
TWIK related potassium channel (TREK) R-HSA-1299503 4.303300e-01 0.366 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.303300e-01 0.366 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.303300e-01 0.366 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.303300e-01 0.366 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 4.303300e-01 0.366 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 4.303300e-01 0.366 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 4.303300e-01 0.366 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 4.303300e-01 0.366 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 1.444115e-01 0.840 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.769210e-01 0.752 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.193663e-01 0.659 0 0
Formation of axial mesoderm R-HSA-9796292 2.193663e-01 0.659 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.636741e-01 0.786 0 0
PI3K/AKT activation R-HSA-198203 2.770147e-01 0.557 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 1.252250e-01 0.902 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.512938e-01 0.820 0 0
Striated Muscle Contraction R-HSA-390522 1.164019e-01 0.934 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.839610e-01 0.735 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.610805e-01 0.442 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.610805e-01 0.442 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.610805e-01 0.442 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.255694e-01 0.647 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.149835e-01 0.502 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.873321e-01 0.727 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.873321e-01 0.727 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.798084e-01 0.553 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.798084e-01 0.553 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.798084e-01 0.553 0 0
Regulation of signaling by CBL R-HSA-912631 2.512391e-01 0.600 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.885175e-01 0.725 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.145431e-01 0.941 0 0
MET promotes cell motility R-HSA-8875878 1.883216e-01 0.725 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.264769e-01 0.645 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.530429e-01 0.452 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 3.530429e-01 0.452 0 0
Netrin mediated repulsion signals R-HSA-418886 4.104769e-01 0.387 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.104769e-01 0.387 0 0
SOS-mediated signalling R-HSA-112412 4.104769e-01 0.387 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 4.104769e-01 0.387 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.104769e-01 0.387 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 5.050974e-01 0.297 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 5.050974e-01 0.297 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 5.050974e-01 0.297 0 0
Axonal growth stimulation R-HSA-209563 5.050974e-01 0.297 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 5.050974e-01 0.297 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.050974e-01 0.297 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 5.050974e-01 0.297 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.050974e-01 0.297 0 0
MET activates PTPN11 R-HSA-8865999 5.050974e-01 0.297 0 0
IRAK4 deficiency (TLR5) R-HSA-5603037 5.050974e-01 0.297 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.453637e-01 0.838 0 0
Meiotic synapsis R-HSA-1221632 1.578474e-01 0.802 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.578474e-01 0.802 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.046428e-01 0.689 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 2.046428e-01 0.689 0 0
Lagging Strand Synthesis R-HSA-69186 3.044565e-01 0.516 0 0
HIV Transcription Elongation R-HSA-167169 2.215186e-01 0.655 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 2.215186e-01 0.655 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.215186e-01 0.655 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 3.424113e-01 0.465 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 3.424113e-01 0.465 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 3.908306e-01 0.408 0 0
Leading Strand Synthesis R-HSA-69109 3.908306e-01 0.408 0 0
Polymerase switching R-HSA-69091 3.908306e-01 0.408 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 3.908306e-01 0.408 0 0
Transcription of the HIV genome R-HSA-167172 1.903644e-01 0.720 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.249533e-01 0.648 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.213805e-01 0.493 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.213805e-01 0.493 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.213805e-01 0.493 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 3.739340e-01 0.427 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.739340e-01 0.427 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.579166e-01 0.339 0 0
MET receptor recycling R-HSA-8875656 4.579166e-01 0.339 0 0
FGFR1b ligand binding and activation R-HSA-190370 4.579166e-01 0.339 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.579166e-01 0.339 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.342063e-01 0.872 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.452372e-01 0.610 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.910166e-01 0.719 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 3.591192e-01 0.445 0 0
Translation initiation complex formation R-HSA-72649 2.611749e-01 0.583 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.458682e-01 0.461 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 3.458682e-01 0.461 0 0
HIV elongation arrest and recovery R-HSA-167287 3.458682e-01 0.461 0 0
Formation of the Early Elongation Complex R-HSA-113418 3.458682e-01 0.461 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 3.458682e-01 0.461 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.458682e-01 0.461 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.280364e-01 0.369 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.280364e-01 0.369 0 0
Nuclear Receptor transcription pathway R-HSA-383280 2.363081e-01 0.627 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.699455e-01 0.569 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.053249e-01 0.392 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.053249e-01 0.392 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.940186e-01 0.532 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.940186e-01 0.532 0 0
Signaling by Erythropoietin R-HSA-9006335 3.705155e-01 0.431 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.705155e-01 0.431 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 3.434365e-01 0.464 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 2.669930e-01 0.574 0 0
Deadenylation of mRNA R-HSA-429947 4.140431e-01 0.383 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 4.363995e-01 0.360 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.363995e-01 0.360 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 4.644003e-01 0.333 0 0
Removal of the Flap Intermediate R-HSA-69166 4.644003e-01 0.333 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.030624e-01 0.298 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 5.030624e-01 0.298 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 5.030624e-01 0.298 0 0
TNFR1-mediated ceramide production R-HSA-5626978 5.700556e-01 0.244 0 0
ATP sensitive Potassium channels R-HSA-1296025 5.700556e-01 0.244 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.700556e-01 0.244 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.700556e-01 0.244 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.700556e-01 0.244 0 0
Recycling pathway of L1 R-HSA-437239 3.706121e-01 0.431 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.852027e-01 0.414 0 0
HIV Transcription Initiation R-HSA-167161 3.852027e-01 0.414 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.852027e-01 0.414 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.014574e-01 0.396 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.444091e-01 0.352 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.997090e-01 0.301 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 4.997090e-01 0.301 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.997090e-01 0.301 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.997090e-01 0.301 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 4.271619e-01 0.369 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.867710e-01 0.413 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.004696e-01 0.397 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.969648e-01 0.304 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.969648e-01 0.304 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 4.969648e-01 0.304 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.456995e-01 0.263 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.456995e-01 0.263 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 3.854300e-01 0.414 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 3.854300e-01 0.414 0 0
Dual incision in TC-NER R-HSA-6782135 4.499481e-01 0.347 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.946836e-01 0.306 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.688440e-01 0.329 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.688440e-01 0.329 0 0
Nucleosome assembly R-HSA-774815 4.688440e-01 0.329 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.909981e-01 0.309 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.514926e-01 0.345 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.894461e-01 0.310 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 5.261896e-01 0.279 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 5.261896e-01 0.279 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.261896e-01 0.279 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.163606e-01 0.287 0 0
Dual Incision in GG-NER R-HSA-5696400 5.163606e-01 0.287 0 0
FGFR2 alternative splicing R-HSA-6803529 5.545649e-01 0.256 0 0
Phase 2 - plateau phase R-HSA-5576893 5.665209e-01 0.247 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.857087e-01 0.232 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 6.264910e-01 0.203 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 6.264910e-01 0.203 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 6.264910e-01 0.203 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 6.264910e-01 0.203 0 0
G2 Phase R-HSA-68911 6.264910e-01 0.203 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 6.264910e-01 0.203 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 6.264910e-01 0.203 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.264910e-01 0.203 0 0
Defective F9 activation R-HSA-9673221 6.264910e-01 0.203 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 6.264910e-01 0.203 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 6.264910e-01 0.203 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 6.264910e-01 0.203 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.208748e-01 0.283 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.208748e-01 0.283 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.253731e-01 0.280 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.622625e-01 0.250 0 0
Regulation of RAS by GAPs R-HSA-5658442 5.691680e-01 0.245 0 0
Interleukin receptor SHC signaling R-HSA-912526 5.820060e-01 0.235 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 5.977975e-01 0.223 0 0
Downstream signal transduction R-HSA-186763 5.948285e-01 0.226 0 0
Trafficking of AMPA receptors R-HSA-399719 5.948285e-01 0.226 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 6.050677e-01 0.218 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.149338e-01 0.211 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.230452e-01 0.205 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.230452e-01 0.205 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 6.230452e-01 0.205 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.230452e-01 0.205 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.253725e-01 0.204 0 0
GAB1 signalosome R-HSA-180292 6.275576e-01 0.202 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.275576e-01 0.202 0 0
PKA activation in glucagon signalling R-HSA-164378 6.275576e-01 0.202 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 6.486049e-01 0.188 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.351325e-01 0.197 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.338320e-01 0.198 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 6.537348e-01 0.185 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.557625e-01 0.183 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.557625e-01 0.183 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 6.577214e-01 0.182 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 6.577214e-01 0.182 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.755214e-01 0.170 0 0
PDE3B signalling R-HSA-165160 6.755214e-01 0.170 0 0
Cam-PDE 1 activation R-HSA-111957 6.755214e-01 0.170 0 0
PKB-mediated events R-HSA-109703 6.755214e-01 0.170 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.755214e-01 0.170 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.755214e-01 0.170 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.755214e-01 0.170 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 6.755214e-01 0.170 0 0
Signaling by RNF43 mutants R-HSA-5340588 6.755214e-01 0.170 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 6.755214e-01 0.170 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 6.755214e-01 0.170 0 0
Signaling by MAPK mutants R-HSA-9652817 6.755214e-01 0.170 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.875678e-01 0.312 0 0
FOXO-mediated transcription R-HSA-9614085 4.803347e-01 0.318 0 0
G0 and Early G1 R-HSA-1538133 1.715615e-01 0.766 0 0
RNA Polymerase III Transcription R-HSA-74158 4.014574e-01 0.396 0 0
Signaling by FGFR1 R-HSA-5654736 5.448803e-01 0.264 0 0
Signaling by FGFR4 R-HSA-5654743 5.760791e-01 0.240 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.155992e-01 0.666 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.567745e-01 0.805 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.644229e-01 0.784 0 0
Cyclin D associated events in G1 R-HSA-69231 2.024349e-01 0.694 0 0
G1 Phase R-HSA-69236 2.024349e-01 0.694 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.306308e-01 0.275 0 0
G-protein beta:gamma signalling R-HSA-397795 6.405193e-01 0.193 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.255694e-01 0.647 0 0
Formation of definitive endoderm R-HSA-9823730 2.775888e-01 0.557 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.132600e-01 0.946 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.318733e-01 0.199 0 0
Signaling by FGFR3 R-HSA-5654741 6.159718e-01 0.210 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.971597e-01 0.527 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.688895e-01 0.772 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.264769e-01 0.645 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.098229e-01 0.293 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.665209e-01 0.247 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.340804e-01 0.873 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.672784e-01 0.330 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.275576e-01 0.202 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.335588e-01 0.874 0 0
Chromosome Maintenance R-HSA-73886 6.213868e-01 0.207 0 0
DNA strand elongation R-HSA-69190 1.715615e-01 0.766 0 0
Aggrephagy R-HSA-9646399 4.909981e-01 0.309 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.665209e-01 0.247 0 0
Myogenesis R-HSA-525793 1.688895e-01 0.772 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.287353e-01 0.641 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.943000e-01 0.404 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.880297e-01 0.312 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.128236e-01 0.290 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.159718e-01 0.210 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.275576e-01 0.202 0 0
DNA Damage Bypass R-HSA-73893 5.497236e-01 0.260 0 0
Oncogene Induced Senescence R-HSA-2559585 2.432057e-01 0.614 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 4.509295e-01 0.346 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.581287e-01 0.182 0 0
Nucleotide Excision Repair R-HSA-5696398 3.836457e-01 0.416 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.395513e-01 0.621 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.499628e-01 0.602 0 0
Metalloprotease DUBs R-HSA-5689901 2.971597e-01 0.527 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.936448e-01 0.713 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 4.053249e-01 0.392 0 0
DNA Double Strand Break Response R-HSA-5693606 2.627885e-01 0.580 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.548623e-01 0.594 0 0
DARPP-32 events R-HSA-180024 5.460714e-01 0.263 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.072598e-01 0.390 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.369567e-01 0.270 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.968039e-01 0.706 0 0
Ion homeostasis R-HSA-5578775 2.940186e-01 0.532 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.094577e-01 0.509 0 0
DAP12 signaling R-HSA-2424491 5.708099e-01 0.244 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 1.854994e-01 0.732 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 1.854994e-01 0.732 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.193011e-01 0.659 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.378612e-01 0.359 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.583162e-01 0.253 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.509295e-01 0.346 0 0
Regulation of CDH11 function R-HSA-9762292 1.132600e-01 0.946 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 2.395513e-01 0.621 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.449128e-01 0.839 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 4.104769e-01 0.387 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 3.739340e-01 0.427 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 5.030624e-01 0.298 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.337928e-01 0.273 0 0
LGI-ADAM interactions R-HSA-5682910 5.857087e-01 0.232 0 0
Peptide chain elongation R-HSA-156902 6.061308e-01 0.217 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.755214e-01 0.170 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.053249e-01 0.392 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 4.061884e-01 0.391 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.293842e-01 0.888 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.591192e-01 0.445 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 6.138420e-01 0.212 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.395513e-01 0.621 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 2.482910e-01 0.605 0 0
Synthesis of DNA R-HSA-69239 2.420550e-01 0.616 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.583162e-01 0.253 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.341223e-01 0.362 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.341223e-01 0.362 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.061478e-01 0.686 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.654921e-01 0.332 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.654921e-01 0.332 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.575108e-01 0.803 0 0
GPVI-mediated activation cascade R-HSA-114604 5.622625e-01 0.250 0 0
G-protein mediated events R-HSA-112040 3.669706e-01 0.435 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.070722e-01 0.684 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.585744e-01 0.587 0 0
Adrenoceptors R-HSA-390696 2.030587e-01 0.692 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 1.905948e-01 0.720 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 3.102184e-01 0.508 0 0
cGMP effects R-HSA-418457 2.491920e-01 0.603 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.885175e-01 0.725 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 4.579166e-01 0.339 0 0
p75NTR regulates axonogenesis R-HSA-193697 5.030624e-01 0.298 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.030624e-01 0.298 0 0
Meiosis R-HSA-1500620 3.328992e-01 0.478 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.800696e-01 0.420 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.946836e-01 0.306 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.622625e-01 0.250 0 0
PKA activation R-HSA-163615 6.275576e-01 0.202 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.428118e-01 0.192 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.557625e-01 0.183 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 6.577214e-01 0.182 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 6.577214e-01 0.182 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.454449e-01 0.837 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 6.180782e-01 0.209 0 0
DNA Replication R-HSA-69306 6.132135e-01 0.212 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.867059e-01 0.232 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.545649e-01 0.256 0 0
Nuclear RNA decay R-HSA-9930044 1.885175e-01 0.725 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.548281e-01 0.450 0 0
Stabilization of p53 R-HSA-69541 6.269237e-01 0.203 0 0
Signaling by FGFR in disease R-HSA-1226099 3.707535e-01 0.431 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 4.681855e-01 0.330 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.232002e-01 0.205 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.839610e-01 0.735 0 0
Repression of WNT target genes R-HSA-4641265 3.908306e-01 0.408 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.642646e-01 0.439 0 0
Long-term potentiation R-HSA-9620244 4.412707e-01 0.355 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.946836e-01 0.306 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.720615e-01 0.173 0 0
Signaling by WNT R-HSA-195721 4.442156e-01 0.352 0 0
Hedgehog 'on' state R-HSA-5632684 4.341223e-01 0.362 0 0
Gene expression (Transcription) R-HSA-74160 1.921898e-01 0.716 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.559473e-01 0.592 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.203893e-01 0.376 0 0
RNA Polymerase II Transcription R-HSA-73857 4.350440e-01 0.361 0 0
Signaling by WNT in cancer R-HSA-4791275 2.896761e-01 0.538 0 0
PLC beta mediated events R-HSA-112043 2.699455e-01 0.569 0 0
Neurexins and neuroligins R-HSA-6794361 1.458162e-01 0.836 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.287353e-01 0.641 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 3.540592e-01 0.451 0 0
Calcineurin activates NFAT R-HSA-2025928 2.395513e-01 0.621 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.102184e-01 0.508 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 2.491920e-01 0.603 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 3.610805e-01 0.442 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.243968e-01 0.649 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.739340e-01 0.427 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.579166e-01 0.339 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.802360e-01 0.744 0 0
IRS-mediated signalling R-HSA-112399 4.314249e-01 0.365 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.875678e-01 0.312 0 0
Formation of the posterior neural plate R-HSA-9832991 5.857087e-01 0.232 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 6.264910e-01 0.203 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 5.554105e-01 0.255 0 0
Eukaryotic Translation Elongation R-HSA-156842 5.722739e-01 0.242 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.338320e-01 0.198 0 0
Opioid Signalling R-HSA-111885 6.493294e-01 0.188 0 0
TNF signaling R-HSA-75893 4.128621e-01 0.384 0 0
Integration of energy metabolism R-HSA-163685 6.585369e-01 0.181 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.584268e-01 0.800 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.885175e-01 0.725 0 0
Cilium Assembly R-HSA-5617833 4.803430e-01 0.318 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.424113e-01 0.465 0 0
Ca-dependent events R-HSA-111996 1.725376e-01 0.763 0 0
Ca2+ pathway R-HSA-4086398 3.548281e-01 0.450 0 0
Response of endothelial cells to shear stress R-HSA-9860931 6.493294e-01 0.188 0 0
Regulation of KIT signaling R-HSA-1433559 2.491920e-01 0.603 0 0
Regulation of CDH1 Function R-HSA-9764561 1.344157e-01 0.872 0 0
Signalling to ERKs R-HSA-187687 2.432057e-01 0.614 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.338320e-01 0.198 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 6.577214e-01 0.182 0 0
Cellular Senescence R-HSA-2559583 1.476753e-01 0.831 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.720615e-01 0.173 0 0
Signaling by SCF-KIT R-HSA-1433557 4.271619e-01 0.369 0 0
Calmodulin induced events R-HSA-111933 1.575108e-01 0.803 0 0
G1/S Transition R-HSA-69206 1.914721e-01 0.718 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.903644e-01 0.720 0 0
Cardiac conduction R-HSA-5576891 3.325078e-01 0.478 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 2.051749e-01 0.688 0 0
Rab regulation of trafficking R-HSA-9007101 1.199625e-01 0.921 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.546161e-01 0.594 0 0
CRMPs in Sema3A signaling R-HSA-399956 4.644003e-01 0.333 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 6.264910e-01 0.203 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.755214e-01 0.170 0 0
Signaling by TGFB family members R-HSA-9006936 5.299957e-01 0.276 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.389033e-01 0.622 0 0
Generation of second messenger molecules R-HSA-202433 3.434365e-01 0.464 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.510898e-01 0.455 0 0
Negative regulation of FLT3 R-HSA-9706369 1.542606e-01 0.812 0 0
CaM pathway R-HSA-111997 1.575108e-01 0.803 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.140846e-01 0.503 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.696654e-01 0.432 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.430959e-01 0.844 0 0
DAG and IP3 signaling R-HSA-1489509 2.181567e-01 0.661 0 0
TRP channels R-HSA-3295583 2.971597e-01 0.527 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.116088e-01 0.506 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 5.460714e-01 0.263 0 0
DNA Repair R-HSA-73894 4.337298e-01 0.363 0 0
MAPK family signaling cascades R-HSA-5683057 1.345226e-01 0.871 0 0
Post NMDA receptor activation events R-HSA-438064 4.822515e-01 0.317 0 0
mRNA Editing R-HSA-75072 5.030624e-01 0.298 0 0
p75NTR recruits signalling complexes R-HSA-209543 6.577214e-01 0.182 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.898627e-01 0.722 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.898627e-01 0.722 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.690344e-01 0.570 0 0
Vesicle-mediated transport R-HSA-5653656 1.297420e-01 0.887 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.431144e-01 0.614 0 0
Signaling by MET R-HSA-6806834 1.224865e-01 0.912 0 0
Signal transduction by L1 R-HSA-445144 2.775888e-01 0.557 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 3.116088e-01 0.506 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.581287e-01 0.182 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.770147e-01 0.557 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.642646e-01 0.439 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.622068e-01 0.335 0 0
L1CAM interactions R-HSA-373760 3.743119e-01 0.427 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.705155e-01 0.431 0 0
Apoptotic factor-mediated response R-HSA-111471 6.275576e-01 0.202 0 0
Specification of the neural plate border R-HSA-9834899 6.557625e-01 0.183 0 0
Autophagy R-HSA-9612973 3.302954e-01 0.481 0 0
IGF1R signaling cascade R-HSA-2428924 4.329187e-01 0.364 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.472029e-01 0.189 0 0
Activation of BH3-only proteins R-HSA-114452 3.952193e-01 0.403 0 0
Cell-cell junction organization R-HSA-421270 2.330601e-01 0.633 0 0
Deubiquitination R-HSA-5688426 2.141619e-01 0.669 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.855676e-01 0.544 0 0
Adherens junctions interactions R-HSA-418990 4.186021e-01 0.378 0 0
Signaling by PTK6 R-HSA-8848021 3.014515e-01 0.521 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.014515e-01 0.521 0 0
HIV Life Cycle R-HSA-162587 2.117252e-01 0.674 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.452219e-01 0.610 0 0
MTF1 activates gene expression R-HSA-5660489 2.070722e-01 0.684 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.442728e-01 0.463 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.442728e-01 0.463 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 3.442728e-01 0.463 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.442728e-01 0.463 0 0
Tandem pore domain potassium channels R-HSA-1296346 1.132600e-01 0.946 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.030587e-01 0.692 0 0
Signaling by AXIN mutants R-HSA-4839735 1.631451e-01 0.787 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.631451e-01 0.787 0 0
Unwinding of DNA R-HSA-176974 2.395513e-01 0.621 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 3.102184e-01 0.508 0 0
mRNA Editing: A to I Conversion R-HSA-75064 4.303300e-01 0.366 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 4.303300e-01 0.366 0 0
Interleukin-33 signaling R-HSA-9014843 4.303300e-01 0.366 0 0
C6 deamination of adenosine R-HSA-75102 4.303300e-01 0.366 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.303300e-01 0.366 0 0
Defective ABCC8 can cause hypo- and hyper-glycemias R-HSA-5683177 4.303300e-01 0.366 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.255694e-01 0.647 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.109615e-01 0.507 0 0
Phase 4 - resting membrane potential R-HSA-5576886 3.109615e-01 0.507 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.104769e-01 0.387 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.050974e-01 0.297 0 0
Smooth Muscle Contraction R-HSA-445355 1.578474e-01 0.802 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.424113e-01 0.465 0 0
Co-stimulation by ICOS R-HSA-9927354 4.579166e-01 0.339 0 0
TBC/RABGAPs R-HSA-8854214 2.936193e-01 0.532 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.699455e-01 0.569 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 2.198513e-01 0.658 0 0
PI3K Cascade R-HSA-109704 3.029846e-01 0.519 0 0
Orc1 removal from chromatin R-HSA-68949 3.390380e-01 0.470 0 0
Electric Transmission Across Gap Junctions R-HSA-112303 5.700556e-01 0.244 0 0
Transmission across Electrical Synapses R-HSA-112307 5.700556e-01 0.244 0 0
Host Interactions of HIV factors R-HSA-162909 3.067611e-01 0.513 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 4.172923e-01 0.380 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.456995e-01 0.263 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.927246e-01 0.307 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.261896e-01 0.279 0 0
Ethanol oxidation R-HSA-71384 5.545649e-01 0.256 0 0
Bicarbonate transporters R-HSA-425381 5.857087e-01 0.232 0 0
Trafficking of myristoylated proteins to the cilium R-HSA-5624138 6.264910e-01 0.203 0 0
Reelin signalling pathway R-HSA-8866376 6.264910e-01 0.203 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.264910e-01 0.203 0 0
Suppression of autophagy R-HSA-9636569 6.264910e-01 0.203 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.230431e-01 0.281 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 5.820060e-01 0.235 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.755214e-01 0.170 0 0
Formation of the Editosome R-HSA-75094 6.755214e-01 0.170 0 0
Phosphorylation of Emi1 R-HSA-176417 6.755214e-01 0.170 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.011562e-01 0.300 0 0
HIV Infection R-HSA-162906 3.110442e-01 0.507 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.046428e-01 0.689 0 0
Cardiogenesis R-HSA-9733709 1.885175e-01 0.725 0 0
Signaling by ERBB4 R-HSA-1236394 4.843592e-01 0.315 0 0
Insulin receptor signalling cascade R-HSA-74751 5.582046e-01 0.253 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 2.971597e-01 0.527 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.505213e-01 0.346 0 0
Macroautophagy R-HSA-1632852 3.044066e-01 0.517 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.644229e-01 0.784 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.537348e-01 0.185 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.007428e-01 0.697 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 6.405193e-01 0.193 0 0
FLT3 signaling in disease R-HSA-9682385 5.622625e-01 0.250 0 0
Heme signaling R-HSA-9707616 5.228940e-01 0.282 0 0
Signaling by TGFBR3 R-HSA-9839373 3.510898e-01 0.455 0 0
Reproduction R-HSA-1474165 4.019595e-01 0.396 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.329094e-01 0.876 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.903644e-01 0.720 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.240521e-01 0.373 0 0
Signal attenuation R-HSA-74749 5.456995e-01 0.263 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.456995e-01 0.263 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.665209e-01 0.247 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.264910e-01 0.203 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.448803e-01 0.264 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.500416e-01 0.187 0 0
Co-stimulation by CD28 R-HSA-389356 1.717199e-01 0.765 0 0
RMTs methylate histone arginines R-HSA-3214858 4.480654e-01 0.349 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.102184e-01 0.508 0 0
Nef and signal transduction R-HSA-164944 3.610805e-01 0.442 0 0
Syndecan interactions R-HSA-3000170 2.272117e-01 0.644 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 4.104769e-01 0.387 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.739340e-01 0.427 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.280364e-01 0.369 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.700556e-01 0.244 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.390233e-01 0.470 0 0
Protein hydroxylation R-HSA-9629569 4.669939e-01 0.331 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.203655e-01 0.284 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.755214e-01 0.170 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.755214e-01 0.170 0 0
MHC class II antigen presentation R-HSA-2132295 1.655540e-01 0.781 0 0
Sensory processing of sound R-HSA-9659379 2.493967e-01 0.603 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 4.280364e-01 0.369 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.338320e-01 0.198 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.661706e-01 0.176 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.885175e-01 0.725 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.553308e-01 0.809 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.842699e-01 0.546 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.568831e-01 0.183 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.732009e-01 0.325 0 0
Inhibition of membrane repair R-HSA-9635644 3.442728e-01 0.463 0 0
Diseases of cellular response to stress R-HSA-9675132 4.303300e-01 0.366 0 0
DSCAM interactions R-HSA-376172 4.303300e-01 0.366 0 0
Diseases of Cellular Senescence R-HSA-9630747 4.303300e-01 0.366 0 0
Synthesis of PI R-HSA-1483226 3.149835e-01 0.502 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.050974e-01 0.297 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 5.050974e-01 0.297 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 3.044565e-01 0.516 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.424113e-01 0.465 0 0
Maturation of nucleoprotein R-HSA-9683610 4.280364e-01 0.369 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.510898e-01 0.455 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.140431e-01 0.383 0 0
Sensory perception of sour taste R-HSA-9729555 5.700556e-01 0.244 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.456995e-01 0.263 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 5.456995e-01 0.263 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.456995e-01 0.263 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.927246e-01 0.307 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.460714e-01 0.263 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.857087e-01 0.232 0 0
Interleukin-36 pathway R-HSA-9014826 6.264910e-01 0.203 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.230452e-01 0.205 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 6.230452e-01 0.205 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.428118e-01 0.192 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.755214e-01 0.170 0 0
Formation of the nephric duct R-HSA-9830364 4.412707e-01 0.355 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.717585e-01 0.173 0 0
Glucose metabolism R-HSA-70326 1.689753e-01 0.772 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 3.610805e-01 0.442 0 0
Histamine receptors R-HSA-390650 5.050974e-01 0.297 0 0
tRNA processing in the nucleus R-HSA-6784531 2.855676e-01 0.544 0 0
Suppression of apoptosis R-HSA-9635465 5.857087e-01 0.232 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.084455e-01 0.216 0 0
Inositol phosphate metabolism R-HSA-1483249 1.147532e-01 0.940 0 0
Formation of the anterior neural plate R-HSA-9823739 4.997090e-01 0.301 0 0
Diseases of DNA repair R-HSA-9675135 1.457288e-01 0.836 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.557625e-01 0.183 0 0
Interleukin-2 family signaling R-HSA-451927 6.472029e-01 0.189 0 0
Regulation of PTEN localization R-HSA-8948747 4.104769e-01 0.387 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 5.050974e-01 0.297 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.125405e-01 0.505 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.940186e-01 0.532 0 0
Dopamine receptors R-HSA-390651 5.700556e-01 0.244 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.700556e-01 0.244 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 5.700556e-01 0.244 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.681855e-01 0.330 0 0
NrCAM interactions R-HSA-447038 6.264910e-01 0.203 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.820060e-01 0.235 0 0
Acetylcholine inhibits contraction of outer hair cells R-HSA-9667769 6.755214e-01 0.170 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.755214e-01 0.170 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.094577e-01 0.509 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.128236e-01 0.290 0 0
Interleukin-7 signaling R-HSA-1266695 6.338320e-01 0.198 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.969648e-01 0.304 0 0
Platelet sensitization by LDL R-HSA-432142 6.275576e-01 0.202 0 0
Maturation of nucleoprotein R-HSA-9694631 6.557625e-01 0.183 0 0
Lipophagy R-HSA-9613354 5.030624e-01 0.298 0 0
Formation of apoptosome R-HSA-111458 5.456995e-01 0.263 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 6.264910e-01 0.203 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 6.621214e-01 0.179 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.755214e-01 0.170 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.299066e-01 0.886 0 0
Nephron development R-HSA-9831926 6.275576e-01 0.202 0 0
IRE1alpha activates chaperones R-HSA-381070 1.871756e-01 0.728 0 0
Influenza Infection R-HSA-168255 5.142358e-01 0.289 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.280364e-01 0.369 0 0
Physiological factors R-HSA-5578768 4.644003e-01 0.333 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 4.505213e-01 0.346 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.261896e-01 0.279 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.918066e-01 0.228 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.579166e-01 0.339 0 0
Vasopressin-like receptors R-HSA-388479 5.700556e-01 0.244 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.755214e-01 0.170 0 0
OAS antiviral response R-HSA-8983711 6.577214e-01 0.182 0 0
Interleukin-12 signaling R-HSA-9020591 6.336148e-01 0.198 0 0
Signaling by Leptin R-HSA-2586552 5.456995e-01 0.263 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 6.768098e-01 0.170 0 0
Ub-specific processing proteases R-HSA-5689880 6.774925e-01 0.169 0 0
Developmental Biology R-HSA-1266738 6.782515e-01 0.169 0 0
Interleukin-1 family signaling R-HSA-446652 6.808568e-01 0.167 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.813119e-01 0.167 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.813119e-01 0.167 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.823965e-01 0.166 0 0
Co-inhibition by CTLA4 R-HSA-389513 6.823965e-01 0.166 0 0
Nephrin family interactions R-HSA-373753 6.823965e-01 0.166 0 0
Signaling by NODAL R-HSA-1181150 6.823965e-01 0.166 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.828625e-01 0.166 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.856912e-01 0.164 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 6.856912e-01 0.164 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.856912e-01 0.164 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.868385e-01 0.163 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.891874e-01 0.162 0 0
Degradation of CDH1 R-HSA-9766229 6.891874e-01 0.162 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.897921e-01 0.161 0 0
FGFR1c ligand binding and activation R-HSA-190373 6.897921e-01 0.161 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.897921e-01 0.161 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 6.897921e-01 0.161 0 0
Signaling by FGFR2 R-HSA-5654738 6.917357e-01 0.160 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 6.917357e-01 0.160 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.919462e-01 0.160 0 0
Hedgehog 'off' state R-HSA-5610787 6.936451e-01 0.159 0 0
Gene Silencing by RNA R-HSA-211000 6.986030e-01 0.156 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.027281e-01 0.153 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.027281e-01 0.153 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.033698e-01 0.153 0 0
Pyroptosis R-HSA-5620971 7.033698e-01 0.153 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 7.038676e-01 0.153 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 7.038676e-01 0.153 0 0
Generic Transcription Pathway R-HSA-212436 7.061192e-01 0.151 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.074632e-01 0.150 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.074632e-01 0.150 0 0
Diseases of programmed cell death R-HSA-9645723 7.094917e-01 0.149 0 0
Selective autophagy R-HSA-9663891 7.094917e-01 0.149 0 0
Signaling by LTK in cancer R-HSA-9842640 7.181181e-01 0.144 0 0
Erythropoietin activates STAT5 R-HSA-9027283 7.181181e-01 0.144 0 0
STAT5 Activation R-HSA-9645135 7.181181e-01 0.144 0 0
Defective CYP11A1 causes AICSR R-HSA-5579026 7.181181e-01 0.144 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 7.181181e-01 0.144 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 7.181181e-01 0.144 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 7.181181e-01 0.144 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.181181e-01 0.144 0 0
Neurofascin interactions R-HSA-447043 7.181181e-01 0.144 0 0
NADPH regeneration R-HSA-389542 7.181181e-01 0.144 0 0
Lipid particle organization R-HSA-8964572 7.181181e-01 0.144 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.193440e-01 0.143 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 7.193440e-01 0.143 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.193440e-01 0.143 0 0
Signal regulatory protein family interactions R-HSA-391160 7.193440e-01 0.143 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.213189e-01 0.142 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 7.217108e-01 0.142 0 0
G1/S-Specific Transcription R-HSA-69205 7.217108e-01 0.142 0 0
Extension of Telomeres R-HSA-180786 7.239126e-01 0.140 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 7.239126e-01 0.140 0 0
ESR-mediated signaling R-HSA-8939211 7.239853e-01 0.140 0 0
mRNA Capping R-HSA-72086 7.243006e-01 0.140 0 0
Late endosomal microautophagy R-HSA-9615710 7.243006e-01 0.140 0 0
Platelet calcium homeostasis R-HSA-418360 7.243006e-01 0.140 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 7.243006e-01 0.140 0 0
Eukaryotic Translation Termination R-HSA-72764 7.256454e-01 0.139 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.309819e-01 0.136 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 7.373701e-01 0.132 0 0
Potassium Channels R-HSA-1296071 7.373701e-01 0.132 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 7.378020e-01 0.132 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.378020e-01 0.132 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.378020e-01 0.132 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.380410e-01 0.132 0 0
DAP12 interactions R-HSA-2172127 7.380410e-01 0.132 0 0
Metabolism of RNA R-HSA-8953854 7.383676e-01 0.132 0 0
Signaling by ERBB2 R-HSA-1227986 7.385409e-01 0.132 0 0
Degradation of DVL R-HSA-4641258 7.398097e-01 0.131 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 7.398097e-01 0.131 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.404371e-01 0.131 0 0
Cellular responses to stress R-HSA-2262752 7.410259e-01 0.130 0 0
UCH proteinases R-HSA-5689603 7.417621e-01 0.130 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.441117e-01 0.128 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.441117e-01 0.128 0 0
Erythropoietin activates RAS R-HSA-9027284 7.464854e-01 0.127 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 7.464854e-01 0.127 0 0
Translesion synthesis by REV1 R-HSA-110312 7.464854e-01 0.127 0 0
p75NTR signals via NF-kB R-HSA-193639 7.464854e-01 0.127 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.464854e-01 0.127 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.464854e-01 0.127 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.464854e-01 0.127 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 7.527660e-01 0.123 0 0
Cellular responses to stimuli R-HSA-8953897 7.528780e-01 0.123 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.529853e-01 0.123 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.529853e-01 0.123 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 7.529853e-01 0.123 0 0
Notch-HLH transcription pathway R-HSA-350054 7.529853e-01 0.123 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.529853e-01 0.123 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.529853e-01 0.123 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 7.540342e-01 0.123 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 7.540342e-01 0.123 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.544200e-01 0.122 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.551249e-01 0.122 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 7.551249e-01 0.122 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 7.551249e-01 0.122 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 7.551249e-01 0.122 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.551249e-01 0.122 0 0
TRIF-mediated programmed cell death R-HSA-2562578 7.551249e-01 0.122 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.551249e-01 0.122 0 0
Disinhibition of SNARE formation R-HSA-114516 7.551249e-01 0.122 0 0
PTK6 Expression R-HSA-8849473 7.551249e-01 0.122 0 0
mRNA Editing: C to U Conversion R-HSA-72200 7.551249e-01 0.122 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.551249e-01 0.122 0 0
Electron transport from NADPH to Ferredoxin R-HSA-2395516 7.551249e-01 0.122 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.551249e-01 0.122 0 0
VLDL clearance R-HSA-8964046 7.551249e-01 0.122 0 0
Ca2+ activated K+ channels R-HSA-1296052 7.551249e-01 0.122 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 7.551249e-01 0.122 0 0
CHL1 interactions R-HSA-447041 7.551249e-01 0.122 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.551249e-01 0.122 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.551249e-01 0.122 0 0
Maturation of replicase proteins R-HSA-9694301 7.551249e-01 0.122 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.570292e-01 0.121 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.595328e-01 0.119 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.595328e-01 0.119 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.595328e-01 0.119 0 0
Signaling by FGFR R-HSA-190236 7.598246e-01 0.119 0 0
Circadian clock R-HSA-9909396 7.622971e-01 0.118 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.628183e-01 0.118 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.628183e-01 0.118 0 0
PTEN Regulation R-HSA-6807070 7.650627e-01 0.116 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.650627e-01 0.116 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.660973e-01 0.116 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.661692e-01 0.116 0 0
Signaling by PDGF R-HSA-186797 7.661692e-01 0.116 0 0
PCP/CE pathway R-HSA-4086400 7.666440e-01 0.115 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.690913e-01 0.114 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.693023e-01 0.114 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 7.713399e-01 0.113 0 0
Translesion synthesis by POLI R-HSA-5656121 7.713399e-01 0.113 0 0
Killing mechanisms R-HSA-9664420 7.713399e-01 0.113 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 7.713399e-01 0.113 0 0
Activation of SMO R-HSA-5635838 7.713399e-01 0.113 0 0
Differentiation of T cells R-HSA-9945266 7.713399e-01 0.113 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.713399e-01 0.113 0 0
Fructose catabolism R-HSA-70350 7.713399e-01 0.113 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 7.713399e-01 0.113 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.735164e-01 0.112 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.735164e-01 0.112 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.804420e-01 0.108 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.808348e-01 0.107 0 0
phospho-PLA2 pathway R-HSA-111995 7.872752e-01 0.104 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.872752e-01 0.104 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.872752e-01 0.104 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 7.872752e-01 0.104 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.872752e-01 0.104 0 0
Activation of RAS in B cells R-HSA-1169092 7.872752e-01 0.104 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.872752e-01 0.104 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.872752e-01 0.104 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.872752e-01 0.104 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.872752e-01 0.104 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.872752e-01 0.104 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.872752e-01 0.104 0 0
Alpha-defensins R-HSA-1462054 7.872752e-01 0.104 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.872752e-01 0.104 0 0
Sodium/Proton exchangers R-HSA-425986 7.872752e-01 0.104 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.872752e-01 0.104 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.872752e-01 0.104 0 0
Glycogen metabolism R-HSA-8982491 7.888726e-01 0.103 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.897921e-01 0.102 0 0
Interleukin-12 family signaling R-HSA-447115 7.898017e-01 0.102 0 0
Selenocysteine synthesis R-HSA-2408557 7.909989e-01 0.102 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 7.920171e-01 0.101 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 7.926264e-01 0.101 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 7.926264e-01 0.101 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 7.926264e-01 0.101 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 7.940401e-01 0.100 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 7.940401e-01 0.100 0 0
Translesion synthesis by POLK R-HSA-5655862 7.940401e-01 0.100 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 7.940401e-01 0.100 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 7.940401e-01 0.100 0 0
Disorders of Developmental Biology R-HSA-9675151 7.940401e-01 0.100 0 0
Passive transport by Aquaporins R-HSA-432047 7.940401e-01 0.100 0 0
Synthesis of PG R-HSA-1483148 7.940401e-01 0.100 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.940401e-01 0.100 0 0
Response to metal ions R-HSA-5660526 7.940401e-01 0.100 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 7.970100e-01 0.099 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.992497e-01 0.097 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.033895e-01 0.095 0 0
Cellular response to hypoxia R-HSA-1234174 8.035691e-01 0.095 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 8.037791e-01 0.095 0 0
Phospholipid metabolism R-HSA-1483257 8.095039e-01 0.092 0 0
Viral mRNA Translation R-HSA-192823 8.101155e-01 0.091 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.103725e-01 0.091 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.103725e-01 0.091 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 8.103725e-01 0.091 0 0
Gap junction trafficking and regulation R-HSA-157858 8.108439e-01 0.091 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 8.112243e-01 0.091 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 8.125538e-01 0.090 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.125538e-01 0.090 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.125538e-01 0.090 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.125538e-01 0.090 0 0
Signaling by Interleukins R-HSA-449147 8.139679e-01 0.089 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.147230e-01 0.089 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 8.147230e-01 0.089 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.147230e-01 0.089 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.147230e-01 0.089 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.147230e-01 0.089 0 0
Interleukin-21 signaling R-HSA-9020958 8.152060e-01 0.089 0 0
WNT mediated activation of DVL R-HSA-201688 8.152060e-01 0.089 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 8.152060e-01 0.089 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 8.152060e-01 0.089 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.152060e-01 0.089 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 8.152060e-01 0.089 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 8.152060e-01 0.089 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 8.152060e-01 0.089 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 8.152060e-01 0.089 0 0
Interleukin-1 processing R-HSA-448706 8.152060e-01 0.089 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 8.152060e-01 0.089 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 8.173652e-01 0.088 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.173652e-01 0.088 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.194428e-01 0.086 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.215642e-01 0.085 0 0
Ribosome-associated quality control R-HSA-9948299 8.217358e-01 0.085 0 0
Signaling by Hedgehog R-HSA-5358351 8.217358e-01 0.085 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.220212e-01 0.085 0 0
Kidney development R-HSA-9830369 8.258728e-01 0.083 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.268167e-01 0.083 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.268167e-01 0.083 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.271087e-01 0.082 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.271087e-01 0.082 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.331803e-01 0.079 0 0
Signaling by NOTCH1 R-HSA-1980143 8.331803e-01 0.079 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 8.335270e-01 0.079 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.335270e-01 0.079 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 8.335270e-01 0.079 0 0
Parasite infection R-HSA-9664407 8.365519e-01 0.078 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 8.365519e-01 0.078 0 0
Leishmania phagocytosis R-HSA-9664417 8.365519e-01 0.078 0 0
Regulation of insulin secretion R-HSA-422356 8.371575e-01 0.077 0 0
MAPK3 (ERK1) activation R-HSA-110056 8.394709e-01 0.076 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 8.394709e-01 0.076 0 0
Metabolism of serotonin R-HSA-380612 8.394709e-01 0.076 0 0
DNA replication initiation R-HSA-68952 8.394709e-01 0.076 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.394709e-01 0.076 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.394709e-01 0.076 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 8.394709e-01 0.076 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 8.394709e-01 0.076 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 8.394709e-01 0.076 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 8.394709e-01 0.076 0 0
Josephin domain DUBs R-HSA-5689877 8.394709e-01 0.076 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 8.396152e-01 0.076 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.404972e-01 0.075 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.404972e-01 0.075 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.404972e-01 0.075 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.404972e-01 0.075 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.404972e-01 0.075 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 8.404972e-01 0.075 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.404972e-01 0.075 0 0
Regulation of Apoptosis R-HSA-169911 8.407124e-01 0.075 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.407124e-01 0.075 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.420235e-01 0.075 0 0
Signaling by BMP R-HSA-201451 8.420235e-01 0.075 0 0
Cristae formation R-HSA-8949613 8.420235e-01 0.075 0 0
Insulin processing R-HSA-264876 8.420235e-01 0.075 0 0
Neuronal System R-HSA-112316 8.449916e-01 0.073 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 8.462828e-01 0.072 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.462828e-01 0.072 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.505889e-01 0.070 0 0
Translesion Synthesis by POLH R-HSA-110320 8.505889e-01 0.070 0 0
RNA Polymerase I Transcription R-HSA-73864 8.518895e-01 0.070 0 0
Amine ligand-binding receptors R-HSA-375280 8.542142e-01 0.068 0 0
Telomere Extension By Telomerase R-HSA-171319 8.560592e-01 0.067 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.568226e-01 0.067 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 8.570284e-01 0.067 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.586255e-01 0.066 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.597163e-01 0.066 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 8.605508e-01 0.065 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.605508e-01 0.065 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 8.605508e-01 0.065 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.605508e-01 0.065 0 0
FGFR2b ligand binding and activation R-HSA-190377 8.605508e-01 0.065 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.605508e-01 0.065 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.605508e-01 0.065 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.605508e-01 0.065 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 8.605508e-01 0.065 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.605508e-01 0.065 0 0
PECAM1 interactions R-HSA-210990 8.605508e-01 0.065 0 0
Interleukin-2 signaling R-HSA-9020558 8.605508e-01 0.065 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.611953e-01 0.065 0 0
Fanconi Anemia Pathway R-HSA-6783310 8.650328e-01 0.063 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.650328e-01 0.063 0 0
Voltage gated Potassium channels R-HSA-1296072 8.652276e-01 0.063 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.660418e-01 0.062 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.660418e-01 0.062 0 0
Glycogen synthesis R-HSA-3322077 8.660418e-01 0.062 0 0
Pregnenolone biosynthesis R-HSA-196108 8.660418e-01 0.062 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 8.660418e-01 0.062 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 8.689910e-01 0.061 0 0
DNA methylation R-HSA-5334118 8.689910e-01 0.061 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 8.689910e-01 0.061 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 8.689910e-01 0.061 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.696470e-01 0.061 0 0
TCR signaling R-HSA-202403 8.737929e-01 0.059 0 0
Signaling by NOTCH3 R-HSA-9012852 8.761174e-01 0.057 0 0
Adipogenesis R-HSA-9843745 8.766733e-01 0.057 0 0
Signaling by Nuclear Receptors R-HSA-9006931 8.775985e-01 0.057 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.788637e-01 0.056 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.788637e-01 0.056 0 0
ERKs are inactivated R-HSA-202670 8.788637e-01 0.056 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.788637e-01 0.056 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.788637e-01 0.056 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.788637e-01 0.056 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.788637e-01 0.056 0 0
Sodium/Calcium exchangers R-HSA-425561 8.788637e-01 0.056 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.788637e-01 0.056 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.788637e-01 0.056 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 8.800139e-01 0.056 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.800139e-01 0.056 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.800139e-01 0.056 0 0
Basigin interactions R-HSA-210991 8.800139e-01 0.056 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 8.800139e-01 0.056 0 0
ER-Phagosome pathway R-HSA-1236974 8.807381e-01 0.055 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 8.808854e-01 0.055 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.808854e-01 0.055 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.808854e-01 0.055 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 8.808854e-01 0.055 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.808854e-01 0.055 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.808854e-01 0.055 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.864316e-01 0.052 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.864316e-01 0.052 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.864316e-01 0.052 0 0
Neutrophil degranulation R-HSA-6798695 8.878597e-01 0.052 0 0
Signaling by NOTCH4 R-HSA-9013694 8.886745e-01 0.051 0 0
Telomere Maintenance R-HSA-157579 8.913213e-01 0.050 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.918083e-01 0.050 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.920150e-01 0.050 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 8.926277e-01 0.049 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 8.926277e-01 0.049 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 8.944034e-01 0.048 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.947726e-01 0.048 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.947726e-01 0.048 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.947726e-01 0.048 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.947726e-01 0.048 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.947726e-01 0.048 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.947726e-01 0.048 0 0
Signaling by LTK R-HSA-9842663 8.947726e-01 0.048 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.947726e-01 0.048 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 8.947726e-01 0.048 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.947726e-01 0.048 0 0
Disorders of Nervous System Development R-HSA-9697154 8.947726e-01 0.048 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 8.947726e-01 0.048 0 0
Pervasive developmental disorders R-HSA-9005895 8.947726e-01 0.048 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.947726e-01 0.048 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.947726e-01 0.048 0 0
Estrogen biosynthesis R-HSA-193144 8.947726e-01 0.048 0 0
Interleukin-15 signaling R-HSA-8983432 8.947726e-01 0.048 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.947726e-01 0.048 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.949789e-01 0.048 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 8.958977e-01 0.048 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.958977e-01 0.048 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.958977e-01 0.048 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.958977e-01 0.048 0 0
Diseases of Immune System R-HSA-5260271 8.958977e-01 0.048 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.958977e-01 0.048 0 0
Gastrulation R-HSA-9758941 8.971185e-01 0.047 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.975694e-01 0.047 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.975694e-01 0.047 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.975694e-01 0.047 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.009343e-01 0.045 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.012281e-01 0.045 0 0
Cellular response to starvation R-HSA-9711097 9.012281e-01 0.045 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.018238e-01 0.045 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.039989e-01 0.044 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.039989e-01 0.044 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.039989e-01 0.044 0 0
Fructose metabolism R-HSA-5652084 9.039989e-01 0.044 0 0
LDL clearance R-HSA-8964038 9.039989e-01 0.044 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.046625e-01 0.044 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.046625e-01 0.044 0 0
Signaling by Insulin receptor R-HSA-74752 9.067462e-01 0.043 0 0
Regulation of beta-cell development R-HSA-186712 9.081985e-01 0.042 0 0
Regulated Necrosis R-HSA-5218859 9.082362e-01 0.042 0 0
Adenylate cyclase activating pathway R-HSA-170660 9.085929e-01 0.042 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.085929e-01 0.042 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 9.085929e-01 0.042 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.085929e-01 0.042 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.085929e-01 0.042 0 0
Chylomicron remodeling R-HSA-8963901 9.085929e-01 0.042 0 0
Mtb iron assimilation by chelation R-HSA-1222449 9.085929e-01 0.042 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 9.085929e-01 0.042 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.085929e-01 0.042 0 0
rRNA modification in the mitochondrion R-HSA-6793080 9.085929e-01 0.042 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 9.085929e-01 0.042 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 9.085929e-01 0.042 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 9.085929e-01 0.042 0 0
Interleukin-6 signaling R-HSA-1059683 9.085929e-01 0.042 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 9.085929e-01 0.042 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.093594e-01 0.041 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.094649e-01 0.041 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.105989e-01 0.041 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.109942e-01 0.040 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.109942e-01 0.040 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.117449e-01 0.040 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.124492e-01 0.040 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.127671e-01 0.040 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.127671e-01 0.040 0 0
Intra-Golgi traffic R-HSA-6811438 9.127671e-01 0.040 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.142362e-01 0.039 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.142362e-01 0.039 0 0
Carnitine shuttle R-HSA-200425 9.142362e-01 0.039 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 9.142362e-01 0.039 0 0
Growth hormone receptor signaling R-HSA-982772 9.142362e-01 0.039 0 0
GABA receptor activation R-HSA-977443 9.149972e-01 0.039 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.166297e-01 0.038 0 0
Meiotic recombination R-HSA-912446 9.166297e-01 0.038 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.166297e-01 0.038 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.168210e-01 0.038 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.193235e-01 0.037 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.193794e-01 0.037 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.193794e-01 0.037 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.193794e-01 0.037 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.193794e-01 0.037 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.196601e-01 0.036 0 0
Retrograde neurotrophin signalling R-HSA-177504 9.205989e-01 0.036 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 9.205989e-01 0.036 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 9.205989e-01 0.036 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.205989e-01 0.036 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 9.205989e-01 0.036 0 0
Hydrolysis of LPC R-HSA-1483115 9.205989e-01 0.036 0 0
Glycerophospholipid catabolism R-HSA-6814848 9.205989e-01 0.036 0 0
Malate-aspartate shuttle R-HSA-9856872 9.205989e-01 0.036 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 9.205989e-01 0.036 0 0
Non-canonical inflammasome activation R-HSA-9686114 9.205989e-01 0.036 0 0
HDL assembly R-HSA-8963896 9.205989e-01 0.036 0 0
Acyl chain remodeling of CL R-HSA-1482798 9.205989e-01 0.036 0 0
P2Y receptors R-HSA-417957 9.205989e-01 0.036 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 9.205989e-01 0.036 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.206692e-01 0.036 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.209150e-01 0.036 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.213531e-01 0.036 0 0
Aquaporin-mediated transport R-HSA-445717 9.213531e-01 0.036 0 0
MAP kinase activation R-HSA-450294 9.213531e-01 0.036 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.217200e-01 0.035 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 9.234412e-01 0.035 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.234412e-01 0.035 0 0
Complex III assembly R-HSA-9865881 9.234412e-01 0.035 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.234412e-01 0.035 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.234412e-01 0.035 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.270368e-01 0.033 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.270368e-01 0.033 0 0
Mitophagy R-HSA-5205647 9.270368e-01 0.033 0 0
Signal amplification R-HSA-392518 9.270368e-01 0.033 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.270368e-01 0.033 0 0
RA biosynthesis pathway R-HSA-5365859 9.270368e-01 0.033 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 9.271547e-01 0.033 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.272887e-01 0.033 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.278187e-01 0.033 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.291834e-01 0.032 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.294736e-01 0.032 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.310285e-01 0.031 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 9.310285e-01 0.031 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 9.310285e-01 0.031 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.310285e-01 0.031 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 9.310285e-01 0.031 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.310285e-01 0.031 0 0
Signaling by Activin R-HSA-1502540 9.310285e-01 0.031 0 0
p38MAPK events R-HSA-171007 9.310285e-01 0.031 0 0
Biotin transport and metabolism R-HSA-196780 9.310285e-01 0.031 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.310285e-01 0.031 0 0
Protein lipoylation R-HSA-9857492 9.310285e-01 0.031 0 0
Other semaphorin interactions R-HSA-416700 9.310285e-01 0.031 0 0
Protein methylation R-HSA-8876725 9.310285e-01 0.031 0 0
DNA Damage Reversal R-HSA-73942 9.310285e-01 0.031 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.317085e-01 0.031 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.317085e-01 0.031 0 0
G protein gated Potassium channels R-HSA-1296059 9.317085e-01 0.031 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.317085e-01 0.031 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.322419e-01 0.030 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.322419e-01 0.030 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.328260e-01 0.030 0 0
Proteasome assembly R-HSA-9907900 9.335144e-01 0.030 0 0
Surfactant metabolism R-HSA-5683826 9.335144e-01 0.030 0 0
Gap junction trafficking R-HSA-190828 9.335144e-01 0.030 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.340208e-01 0.030 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.340208e-01 0.030 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.340208e-01 0.030 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.347331e-01 0.029 0 0
Base Excision Repair R-HSA-73884 9.361992e-01 0.029 0 0
Ion transport by P-type ATPases R-HSA-936837 9.379866e-01 0.028 0 0
MET activates PTK2 signaling R-HSA-8874081 9.391255e-01 0.027 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.391255e-01 0.027 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.391255e-01 0.027 0 0
Sphingolipid catabolism R-HSA-9845614 9.391255e-01 0.027 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.391255e-01 0.027 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.391255e-01 0.027 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 9.391255e-01 0.027 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.393666e-01 0.027 0 0
Somitogenesis R-HSA-9824272 9.393666e-01 0.027 0 0
Co-inhibition by PD-1 R-HSA-389948 9.395420e-01 0.027 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.400886e-01 0.027 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.400886e-01 0.027 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.400886e-01 0.027 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 9.400886e-01 0.027 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 9.400886e-01 0.027 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 9.400886e-01 0.027 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.400886e-01 0.027 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.400886e-01 0.027 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.400886e-01 0.027 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 9.400886e-01 0.027 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 9.400886e-01 0.027 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.403833e-01 0.027 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.403833e-01 0.027 0 0
Glycosphingolipid transport R-HSA-9845576 9.403833e-01 0.027 0 0
HDACs deacetylate histones R-HSA-3214815 9.405225e-01 0.027 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.410548e-01 0.026 0 0
Platelet homeostasis R-HSA-418346 9.414723e-01 0.026 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.434518e-01 0.025 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.434518e-01 0.025 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.447458e-01 0.025 0 0
Protein ubiquitination R-HSA-8852135 9.456159e-01 0.024 0 0
Packaging Of Telomere Ends R-HSA-171306 9.457729e-01 0.024 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.457729e-01 0.024 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 9.457729e-01 0.024 0 0
Degradation of AXIN R-HSA-4641257 9.461731e-01 0.024 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.479591e-01 0.023 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.479591e-01 0.023 0 0
Galactose catabolism R-HSA-70370 9.479591e-01 0.023 0 0
Coenzyme A biosynthesis R-HSA-196783 9.479591e-01 0.023 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.479591e-01 0.023 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.479591e-01 0.023 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.479591e-01 0.023 0 0
Stimuli-sensing channels R-HSA-2672351 9.486382e-01 0.023 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.514361e-01 0.022 0 0
Interleukin-1 signaling R-HSA-9020702 9.517157e-01 0.021 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.517248e-01 0.021 0 0
Adaptive Immune System R-HSA-1280218 9.532247e-01 0.021 0 0
GPER1 signaling R-HSA-9634597 9.542161e-01 0.020 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.547960e-01 0.020 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.547960e-01 0.020 0 0
Glycogen storage diseases R-HSA-3229121 9.547960e-01 0.020 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.547960e-01 0.020 0 0
Catecholamine biosynthesis R-HSA-209905 9.547960e-01 0.020 0 0
Choline catabolism R-HSA-6798163 9.547960e-01 0.020 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 9.547960e-01 0.020 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.550235e-01 0.020 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.550235e-01 0.020 0 0
Mitochondrial biogenesis R-HSA-1592230 9.553567e-01 0.020 0 0
Integrin cell surface interactions R-HSA-216083 9.569732e-01 0.019 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.570493e-01 0.019 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.580636e-01 0.019 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.582894e-01 0.019 0 0
Toll-like Receptor Cascades R-HSA-168898 9.589919e-01 0.018 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.605513e-01 0.017 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.605513e-01 0.017 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 9.607351e-01 0.017 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.607351e-01 0.017 0 0
Presynaptic function of Kainate receptors R-HSA-500657 9.607351e-01 0.017 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.607351e-01 0.017 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.607351e-01 0.017 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.607351e-01 0.017 0 0
Tie2 Signaling R-HSA-210993 9.607351e-01 0.017 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.607351e-01 0.017 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.616372e-01 0.017 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.618084e-01 0.017 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.618084e-01 0.017 0 0
Neurotransmitter clearance R-HSA-112311 9.618084e-01 0.017 0 0
Interleukin-17 signaling R-HSA-448424 9.621597e-01 0.017 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 9.628458e-01 0.016 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.635712e-01 0.016 0 0
Maturation of spike protein R-HSA-9694548 9.644812e-01 0.016 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.644812e-01 0.016 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.644812e-01 0.016 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.649990e-01 0.015 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.656462e-01 0.015 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.656916e-01 0.015 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.658942e-01 0.015 0 0
Pyrimidine biosynthesis R-HSA-500753 9.658942e-01 0.015 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.658942e-01 0.015 0 0
The NLRP3 inflammasome R-HSA-844456 9.658942e-01 0.015 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.658942e-01 0.015 0 0
Diseases of hemostasis R-HSA-9671793 9.658942e-01 0.015 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.658942e-01 0.015 0 0
Other interleukin signaling R-HSA-449836 9.658942e-01 0.015 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.658942e-01 0.015 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.659872e-01 0.015 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.660236e-01 0.015 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.660587e-01 0.015 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.660587e-01 0.015 0 0
Budding and maturation of HIV virion R-HSA-162588 9.660587e-01 0.015 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.660587e-01 0.015 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.661476e-01 0.015 0 0
Interferon Signaling R-HSA-913531 9.674006e-01 0.014 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.680398e-01 0.014 0 0
Translation of Structural Proteins R-HSA-9683701 9.680398e-01 0.014 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.688236e-01 0.014 0 0
Developmental Cell Lineages R-HSA-9734767 9.697148e-01 0.013 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.698518e-01 0.013 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.703756e-01 0.013 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.703756e-01 0.013 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.703756e-01 0.013 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.703756e-01 0.013 0 0
Activation of GABAB receptors R-HSA-991365 9.712596e-01 0.013 0 0
GABA B receptor activation R-HSA-977444 9.712596e-01 0.013 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.712596e-01 0.013 0 0
Depyrimidination R-HSA-73928 9.712596e-01 0.013 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.732344e-01 0.012 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.732344e-01 0.012 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.741704e-01 0.011 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.742685e-01 0.011 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.742685e-01 0.011 0 0
Signalling to RAS R-HSA-167044 9.742685e-01 0.011 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.742685e-01 0.011 0 0
ERK/MAPK targets R-HSA-198753 9.742685e-01 0.011 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.742685e-01 0.011 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.742685e-01 0.011 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.742685e-01 0.011 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.742685e-01 0.011 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.742685e-01 0.011 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.754465e-01 0.011 0 0
Potential therapeutics for SARS R-HSA-9679191 9.770681e-01 0.010 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.776500e-01 0.010 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.776500e-01 0.010 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.776500e-01 0.010 0 0
Assembly Of The HIV Virion R-HSA-175474 9.776500e-01 0.010 0 0
Serine metabolism R-HSA-977347 9.776500e-01 0.010 0 0
Glutathione synthesis and recycling R-HSA-174403 9.776500e-01 0.010 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.776500e-01 0.010 0 0
Collagen formation R-HSA-1474290 9.780484e-01 0.010 0 0
Platelet degranulation R-HSA-114608 9.787514e-01 0.009 0 0
NOD1/2 Signaling Pathway R-HSA-168638 9.789335e-01 0.009 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.789335e-01 0.009 0 0
Signaling by NOTCH2 R-HSA-1980145 9.789335e-01 0.009 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 9.789335e-01 0.009 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.791729e-01 0.009 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.791729e-01 0.009 0 0
Translation of Structural Proteins R-HSA-9694635 9.793287e-01 0.009 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.805872e-01 0.009 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.805872e-01 0.009 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.805872e-01 0.009 0 0
Signaling by KIT in disease R-HSA-9669938 9.805872e-01 0.009 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.805872e-01 0.009 0 0
Synthesis of PA R-HSA-1483166 9.809831e-01 0.008 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.813135e-01 0.008 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.824094e-01 0.008 0 0
Signaling by NOTCH R-HSA-157118 9.826110e-01 0.008 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.828027e-01 0.008 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.831386e-01 0.007 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.831386e-01 0.007 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.831386e-01 0.007 0 0
Formation of the ureteric bud R-HSA-9830674 9.831386e-01 0.007 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.831386e-01 0.007 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.831386e-01 0.007 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.831386e-01 0.007 0 0
Interleukin-20 family signaling R-HSA-8854691 9.831386e-01 0.007 0 0
rRNA processing R-HSA-72312 9.831761e-01 0.007 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.832429e-01 0.007 0 0
Triglyceride catabolism R-HSA-163560 9.834483e-01 0.007 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.834483e-01 0.007 0 0
PKR-mediated signaling R-HSA-9833482 9.841808e-01 0.007 0 0
Peroxisomal protein import R-HSA-9033241 9.844565e-01 0.007 0 0
COPII-mediated vesicle transport R-HSA-204005 9.847746e-01 0.007 0 0
Gluconeogenesis R-HSA-70263 9.849806e-01 0.007 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.853378e-01 0.006 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.853378e-01 0.006 0 0
Cleavage of the damaged purine R-HSA-110331 9.853378e-01 0.006 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.853378e-01 0.006 0 0
NCAM1 interactions R-HSA-419037 9.853378e-01 0.006 0 0
Collagen chain trimerization R-HSA-8948216 9.853378e-01 0.006 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 9.853549e-01 0.006 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.853549e-01 0.006 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.853549e-01 0.006 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.853549e-01 0.006 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.853549e-01 0.006 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.853549e-01 0.006 0 0
Interleukin-6 family signaling R-HSA-6783589 9.853549e-01 0.006 0 0
HCMV Late Events R-HSA-9610379 9.855124e-01 0.006 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.859586e-01 0.006 0 0
SLC transporter disorders R-HSA-5619102 9.863799e-01 0.006 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.865420e-01 0.006 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.870167e-01 0.006 0 0
Depurination R-HSA-73927 9.870167e-01 0.006 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.872799e-01 0.006 0 0
Hyaluronan degradation R-HSA-2160916 9.872799e-01 0.006 0 0
Laminin interactions R-HSA-3000157 9.872799e-01 0.006 0 0
Transmission across Chemical Synapses R-HSA-112315 9.876038e-01 0.005 0 0
Hemostasis R-HSA-109582 9.878546e-01 0.005 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.885077e-01 0.005 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.886953e-01 0.005 0 0
HCMV Early Events R-HSA-9609690 9.887863e-01 0.005 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.889520e-01 0.005 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.889520e-01 0.005 0 0
The phototransduction cascade R-HSA-2514856 9.892167e-01 0.005 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.903532e-01 0.004 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.904043e-01 0.004 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.904043e-01 0.004 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.904043e-01 0.004 0 0
Triglyceride biosynthesis R-HSA-75109 9.904043e-01 0.004 0 0
Synthesis of PE R-HSA-1483213 9.904043e-01 0.004 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.904265e-01 0.004 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.910054e-01 0.004 0 0
PPARA activates gene expression R-HSA-1989781 9.912028e-01 0.004 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.916659e-01 0.004 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.916659e-01 0.004 0 0
Inflammasomes R-HSA-622312 9.916659e-01 0.004 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.916659e-01 0.004 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.922894e-01 0.003 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.923779e-01 0.003 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.927616e-01 0.003 0 0
Glucagon-type ligand receptors R-HSA-420092 9.927616e-01 0.003 0 0
ABC transporter disorders R-HSA-5619084 9.930030e-01 0.003 0 0
Neddylation R-HSA-8951664 9.932592e-01 0.003 0 0
Interferon alpha/beta signaling R-HSA-909733 9.936780e-01 0.003 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.936780e-01 0.003 0 0
Defective pyroptosis R-HSA-9710421 9.937876e-01 0.003 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.938473e-01 0.003 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.938799e-01 0.003 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.939472e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.942886e-01 0.002 0 0
Dectin-2 family R-HSA-5621480 9.945071e-01 0.002 0 0
tRNA processing R-HSA-72306 9.945277e-01 0.002 0 0
Cargo concentration in the ER R-HSA-5694530 9.945400e-01 0.002 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.945400e-01 0.002 0 0
Ion channel transport R-HSA-983712 9.946493e-01 0.002 0 0
Amyloid fiber formation R-HSA-977225 9.948118e-01 0.002 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.950493e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.950493e-01 0.002 0 0
Selenoamino acid metabolism R-HSA-2408522 9.954372e-01 0.002 0 0
Leishmania infection R-HSA-9658195 9.954783e-01 0.002 0 0
Parasitic Infection Pathways R-HSA-9824443 9.954783e-01 0.002 0 0
ECM proteoglycans R-HSA-3000178 9.955500e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.956271e-01 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.956271e-01 0.002 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.957210e-01 0.002 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.957210e-01 0.002 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.957210e-01 0.002 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.958815e-01 0.002 0 0
RAB geranylgeranylation R-HSA-8873719 9.961004e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.961004e-01 0.002 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.962232e-01 0.002 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.962232e-01 0.002 0 0
Intraflagellar transport R-HSA-5620924 9.966674e-01 0.001 0 0
Metal ion SLC transporters R-HSA-425410 9.966674e-01 0.001 0 0
Extracellular matrix organization R-HSA-1474244 9.968088e-01 0.001 0 0
eNOS activation R-HSA-203615 9.968936e-01 0.001 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.968936e-01 0.001 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.968936e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.968936e-01 0.001 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.968936e-01 0.001 0 0
Gap junction assembly R-HSA-190861 9.968936e-01 0.001 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.968936e-01 0.001 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.969286e-01 0.001 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.971064e-01 0.001 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.973022e-01 0.001 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.973022e-01 0.001 0 0
PERK regulates gene expression R-HSA-381042 9.973022e-01 0.001 0 0
SARS-CoV Infections R-HSA-9679506 9.973185e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.974071e-01 0.001 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.974548e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.975126e-01 0.001 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.975424e-01 0.001 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.979652e-01 0.001 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.979652e-01 0.001 0 0
Lysine catabolism R-HSA-71064 9.979652e-01 0.001 0 0
Metabolism of folate and pterines R-HSA-196757 9.979652e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.980528e-01 0.001 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.981293e-01 0.001 0 0
Downstream TCR signaling R-HSA-202424 9.981348e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.982238e-01 0.001 0 0
ABC-family proteins mediated transport R-HSA-382556 9.982269e-01 0.001 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.982329e-01 0.001 0 0
Purine salvage R-HSA-74217 9.982329e-01 0.001 0 0
Elastic fibre formation R-HSA-1566948 9.982329e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.982676e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.982676e-01 0.001 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.984654e-01 0.001 0 0
Pentose phosphate pathway R-HSA-71336 9.984654e-01 0.001 0 0
RAS processing R-HSA-9648002 9.984654e-01 0.001 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.984654e-01 0.001 0 0
G alpha (z) signalling events R-HSA-418597 9.986213e-01 0.001 0 0
Protein folding R-HSA-391251 9.986374e-01 0.001 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.986523e-01 0.001 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.986673e-01 0.001 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.986673e-01 0.001 0 0
Tryptophan catabolism R-HSA-71240 9.986673e-01 0.001 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.987857e-01 0.001 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.987971e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.987971e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.988166e-01 0.001 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.988426e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.988966e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.989177e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.990384e-01 0.000 0 0
HCMV Infection R-HSA-9609646 9.990430e-01 0.000 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.991272e-01 0.000 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.991272e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.992304e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.992416e-01 0.000 0 0
Defensins R-HSA-1461973 9.992420e-01 0.000 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.992420e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.993122e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.993267e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.993584e-01 0.000 0 0
Interferon gamma signaling R-HSA-877300 9.994057e-01 0.000 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.994284e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.994960e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.995690e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.995705e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.995719e-01 0.000 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.996257e-01 0.000 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.996515e-01 0.000 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.996750e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997034e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.997246e-01 0.000 0 0
Cellular response to chemical stress R-HSA-9711123 9.997443e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.997549e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.997549e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.997719e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998232e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998232e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998636e-01 0.000 0 0
Digestion R-HSA-8935690 9.998790e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.998949e-01 0.000 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.999280e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999283e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999289e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.999289e-01 0.000 0 0
RSV-host interactions R-HSA-9833110 9.999311e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999311e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.999312e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.999312e-01 0.000 0 0
Immune System R-HSA-168256 9.999342e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999376e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.999403e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.999403e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999427e-01 0.000 0 0
Mitochondrial protein import R-HSA-1268020 9.999482e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999520e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999550e-01 0.000 0 0
Digestion and absorption R-HSA-8963743 9.999550e-01 0.000 0 0
Latent infection - Other responses of Mtb to phagocytosis R-HSA-1222499 9.999661e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999691e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999698e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999741e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.999744e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999778e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999871e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999874e-01 0.000 0 0
Protein localization R-HSA-9609507 9.999883e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999903e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999924e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.999946e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999955e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999970e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999988e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999988e-01 0.000 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.999989e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999989e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999989e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999991e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999993e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999994e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999995e-01 0.000 0 0
Viral Infection Pathways R-HSA-9824446 9.999996e-01 0.000 0 0
Translation R-HSA-72766 9.999996e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999996e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999996e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999997e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999998e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999998e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999999e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999999e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999999e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Regulation of Complement cascade R-HSA-977606 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 1.000000e+00 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Infectious disease R-HSA-5663205 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Disease R-HSA-1643685 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 2.997602e-15 14.523 0 0
Nervous system development R-HSA-9675108 1.121325e-14 13.950 0 0
Cell Cycle R-HSA-1640170 7.893686e-14 13.103 0 0
Cellular response to heat stress R-HSA-3371556 2.409184e-13 12.618 0 0
Metabolism of RNA R-HSA-8953854 3.242961e-13 12.489 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.452727e-12 11.838 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 2.016276e-12 11.695 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.840284e-12 11.547 0 0
Eukaryotic Translation Elongation R-HSA-156842 3.748002e-12 11.426 0 0
HSF1-dependent transactivation R-HSA-3371571 4.079626e-12 11.389 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.024902e-11 10.989 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.044731e-11 10.981 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.044731e-11 10.981 0 0
Signaling by ROBO receptors R-HSA-376176 3.236122e-11 10.490 0 0
Cell Cycle, Mitotic R-HSA-69278 1.246159e-10 9.904 0 0
Cell Cycle Checkpoints R-HSA-69620 1.286949e-10 9.890 0 0
Formation of a pool of free 40S subunits R-HSA-72689 1.574922e-10 9.803 0 0
Peptide chain elongation R-HSA-156902 1.903233e-10 9.721 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 2.323203e-10 9.634 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.634063e-10 9.579 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.233287e-10 9.373 0 0
Attenuation phase R-HSA-3371568 5.048283e-10 9.297 0 0
M Phase R-HSA-68886 5.014779e-10 9.300 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.485833e-10 9.261 0 0
rRNA processing R-HSA-72312 6.201053e-10 9.208 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 1.075874e-09 8.968 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.084776e-09 8.965 0 0
Nucleosome assembly R-HSA-774815 1.084776e-09 8.965 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.428302e-09 8.845 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.494515e-09 8.825 0 0
Apoptotic execution phase R-HSA-75153 1.568986e-09 8.804 0 0
Cellular Senescence R-HSA-2559583 1.772112e-09 8.752 0 0
Cell-Cell communication R-HSA-1500931 2.002116e-09 8.699 0 0
Ribosome-associated quality control R-HSA-9948299 2.389800e-09 8.622 0 0
HSF1 activation R-HSA-3371511 2.522397e-09 8.598 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.599518e-09 8.444 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.523782e-09 8.453 0 0
Eukaryotic Translation Termination R-HSA-72764 6.357507e-09 8.197 0 0
Chromatin organization R-HSA-4839726 6.988265e-09 8.156 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 1.026166e-08 7.989 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 1.026166e-08 7.989 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.207118e-08 7.918 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.661653e-08 7.779 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.143596e-08 7.669 0 0
Mitotic Prophase R-HSA-68875 2.535185e-08 7.596 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.370477e-08 7.472 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 5.207728e-08 7.283 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.875466e-08 7.231 0 0
Chromatin modifying enzymes R-HSA-3247509 6.323316e-08 7.199 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.293149e-08 7.137 0 0
Selenocysteine synthesis R-HSA-2408557 7.418912e-08 7.130 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.093142e-08 7.041 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.996692e-08 7.046 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.629740e-08 7.016 0 0
Viral mRNA Translation R-HSA-192823 1.111567e-07 6.954 0 0
Cell junction organization R-HSA-446728 1.163094e-07 6.934 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.735161e-07 6.761 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 2.084084e-07 6.681 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.084391e-07 6.681 0 0
Meiotic synapsis R-HSA-1221632 2.576530e-07 6.589 0 0
PRC2 methylates histones and DNA R-HSA-212300 2.746004e-07 6.561 0 0
G2/M Checkpoints R-HSA-69481 2.983435e-07 6.525 0 0
Translation initiation complex formation R-HSA-72649 3.396506e-07 6.469 0 0
Influenza Infection R-HSA-168255 3.810174e-07 6.419 0 0
Apoptosis R-HSA-109581 4.129960e-07 6.384 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 4.399358e-07 6.357 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.563951e-07 6.341 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.798842e-07 6.237 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.817826e-07 6.235 0 0
Chromosome Maintenance R-HSA-73886 6.540364e-07 6.184 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.825720e-07 6.166 0 0
DNA Double Strand Break Response R-HSA-5693606 7.378933e-07 6.132 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.174089e-07 6.144 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.106012e-07 6.148 0 0
EPH-Ephrin signaling R-HSA-2682334 7.973609e-07 6.098 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.681225e-07 6.014 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 1.009734e-06 5.996 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.110097e-06 5.955 0 0
Meiosis R-HSA-1500620 1.177434e-06 5.929 0 0
Cellular response to starvation R-HSA-9711097 1.359022e-06 5.867 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 1.365295e-06 5.865 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.466772e-06 5.834 0 0
DNA methylation R-HSA-5334118 1.517398e-06 5.819 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.576023e-06 5.802 0 0
HDACs deacetylate histones R-HSA-3214815 1.595883e-06 5.797 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.706306e-06 5.768 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.932049e-06 5.714 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.970300e-06 5.705 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.160433e-06 5.665 0 0
Programmed Cell Death R-HSA-5357801 2.349681e-06 5.629 0 0
Diseases of programmed cell death R-HSA-9645723 2.585885e-06 5.587 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.719899e-06 5.565 0 0
Homology Directed Repair R-HSA-5693538 2.752598e-06 5.560 0 0
Defective pyroptosis R-HSA-9710421 3.235548e-06 5.490 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.394255e-06 5.469 0 0
Packaging Of Telomere Ends R-HSA-171306 3.406784e-06 5.468 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.876650e-06 5.312 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.876650e-06 5.312 0 0
Adherens junctions interactions R-HSA-418990 4.887961e-06 5.311 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.313474e-06 5.275 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 6.556484e-06 5.183 0 0
Meiotic recombination R-HSA-912446 7.131193e-06 5.147 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.170866e-06 5.144 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.710029e-06 5.113 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.313292e-06 5.080 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.814184e-06 5.055 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.299249e-06 5.032 0 0
HATs acetylate histones R-HSA-3214847 9.411800e-06 5.026 0 0
Semaphorin interactions R-HSA-373755 1.016685e-05 4.993 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 1.072495e-05 4.970 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.077279e-05 4.968 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.402127e-05 4.853 0 0
Signaling by WNT R-HSA-195721 1.462648e-05 4.835 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 1.526178e-05 4.816 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.542494e-05 4.812 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.705257e-05 4.768 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.753069e-05 4.756 0 0
Cell-cell junction organization R-HSA-421270 1.788996e-05 4.747 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.959152e-05 4.708 0 0
RNA Polymerase I Transcription R-HSA-73864 2.209398e-05 4.656 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.352668e-05 4.628 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.157540e-05 4.501 0 0
Gene Silencing by RNA R-HSA-211000 3.813600e-05 4.419 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.116315e-05 4.385 0 0
Ephrin signaling R-HSA-3928664 4.233533e-05 4.373 0 0
Interleukin-12 signaling R-HSA-9020591 4.302730e-05 4.366 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.584849e-05 4.339 0 0
DNA Replication Pre-Initiation R-HSA-69002 5.084789e-05 4.294 0 0
Selenoamino acid metabolism R-HSA-2408522 7.187708e-05 4.143 0 0
L1CAM interactions R-HSA-373760 7.395911e-05 4.131 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.990968e-05 4.097 0 0
SARS-CoV-1-host interactions R-HSA-9692914 8.001742e-05 4.097 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 8.160258e-05 4.088 0 0
Signaling downstream of RAS mutants R-HSA-9649948 8.160258e-05 4.088 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 8.160258e-05 4.088 0 0
Signaling by RAS mutants R-HSA-6802949 8.160258e-05 4.088 0 0
Folding of actin by CCT/TriC R-HSA-390450 8.524489e-05 4.069 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.640708e-05 4.063 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.524489e-05 4.069 0 0
Cleavage of the damaged purine R-HSA-110331 8.921760e-05 4.050 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.291306e-05 4.032 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.291306e-05 4.032 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.085104e-04 3.965 0 0
Depyrimidination R-HSA-73928 1.085104e-04 3.965 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.127238e-04 3.948 0 0
Depurination R-HSA-73927 1.136401e-04 3.944 0 0
Striated Muscle Contraction R-HSA-390522 1.155070e-04 3.937 0 0
Mitotic Anaphase R-HSA-68882 1.292552e-04 3.889 0 0
Translation R-HSA-72766 1.295099e-04 3.888 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.486653e-04 3.828 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.401523e-04 3.853 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.401523e-04 3.853 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.416543e-04 3.849 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.489559e-04 3.827 0 0
Signal Transduction R-HSA-162582 1.520158e-04 3.818 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.681195e-04 3.774 0 0
Mitotic Prometaphase R-HSA-68877 1.891113e-04 3.723 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.990847e-04 3.701 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.078532e-04 3.682 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.124279e-04 3.673 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.142110e-04 3.669 0 0
Signaling by ALK in cancer R-HSA-9700206 2.142110e-04 3.669 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.168294e-04 3.664 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.168294e-04 3.664 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.206604e-04 3.656 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.429530e-04 3.614 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.526639e-04 3.597 0 0
Developmental Biology R-HSA-1266738 2.520014e-04 3.599 0 0
Amyloid fiber formation R-HSA-977225 2.561753e-04 3.591 0 0
Interleukin-12 family signaling R-HSA-447115 2.899675e-04 3.538 0 0
Smooth Muscle Contraction R-HSA-445355 3.318218e-04 3.479 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 3.976585e-04 3.400 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.579983e-04 3.339 0 0
Reproduction R-HSA-1474165 5.041108e-04 3.297 0 0
EPHB-mediated forward signaling R-HSA-3928662 5.115207e-04 3.291 0 0
HDMs demethylate histones R-HSA-3214842 5.357760e-04 3.271 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.357760e-04 3.271 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.439573e-04 3.264 0 0
Signaling by VEGF R-HSA-194138 5.467936e-04 3.262 0 0
mRNA Splicing R-HSA-72172 5.552193e-04 3.256 0 0
Muscle contraction R-HSA-397014 5.924809e-04 3.227 0 0
Telomere Maintenance R-HSA-157579 6.182501e-04 3.209 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.649893e-04 3.177 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.054590e-04 3.152 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.928817e-04 3.049 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.219123e-04 3.085 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 9.446025e-04 3.025 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 9.474525e-04 3.023 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.029828e-03 2.987 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.031166e-03 2.987 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.031166e-03 2.987 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.042964e-03 2.982 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.081138e-03 2.966 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.082609e-03 2.966 0 0
Separation of Sister Chromatids R-HSA-2467813 1.126717e-03 2.948 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.195870e-03 2.922 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.287586e-03 2.890 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.287586e-03 2.890 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.309367e-03 2.883 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.364800e-03 2.865 0 0
Membrane Trafficking R-HSA-199991 1.375440e-03 2.862 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.400281e-03 2.854 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.508509e-03 2.821 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.675801e-03 2.776 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.645732e-03 2.784 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.586401e-03 2.800 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.586401e-03 2.800 0 0
DNA Replication R-HSA-69306 1.505322e-03 2.822 0 0
Nephrin family interactions R-HSA-373753 1.508509e-03 2.821 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.686673e-03 2.773 0 0
Regulation of CDH1 Function R-HSA-9764561 1.735532e-03 2.761 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.741708e-03 2.759 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.019874e-03 2.695 0 0
Co-inhibition by PD-1 R-HSA-389948 2.157128e-03 2.666 0 0
DNA Repair R-HSA-73894 2.164856e-03 2.665 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.294619e-03 2.639 0 0
CaM pathway R-HSA-111997 2.320533e-03 2.634 0 0
Calmodulin induced events R-HSA-111933 2.320533e-03 2.634 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.423548e-03 2.616 0 0
Recycling pathway of L1 R-HSA-437239 2.425738e-03 2.615 0 0
Deubiquitination R-HSA-5688426 2.710905e-03 2.567 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 2.737838e-03 2.563 0 0
Josephin domain DUBs R-HSA-5689877 2.737838e-03 2.563 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 2.737838e-03 2.563 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 2.737838e-03 2.563 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.771951e-03 2.557 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.771951e-03 2.557 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.786834e-03 2.555 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.803145e-03 2.552 0 0
Nef and signal transduction R-HSA-164944 2.803145e-03 2.552 0 0
IRE1alpha activates chaperones R-HSA-381070 2.828990e-03 2.548 0 0
Ca-dependent events R-HSA-111996 2.849451e-03 2.545 0 0
Response of endothelial cells to shear stress R-HSA-9860931 2.955013e-03 2.529 0 0
HIV Infection R-HSA-162906 3.199118e-03 2.495 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.319606e-03 2.479 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.195315e-03 2.495 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.064182e-03 2.514 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.064340e-03 2.514 0 0
Protein ubiquitination R-HSA-8852135 3.556213e-03 2.449 0 0
Host Interactions of HIV factors R-HSA-162909 3.608886e-03 2.443 0 0
Estrogen-dependent gene expression R-HSA-9018519 3.840647e-03 2.416 0 0
HIV Life Cycle R-HSA-162587 3.901576e-03 2.409 0 0
MAPK family signaling cascades R-HSA-5683057 3.913319e-03 2.407 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 3.916119e-03 2.407 0 0
Glycolysis R-HSA-70171 3.980108e-03 2.400 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.991571e-03 2.399 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.310089e-03 2.366 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.362252e-03 2.360 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 4.408286e-03 2.356 0 0
Intracellular signaling by second messengers R-HSA-9006925 4.585175e-03 2.339 0 0
DAG and IP3 signaling R-HSA-1489509 4.596725e-03 2.338 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.608385e-03 2.336 0 0
Nuclear import of Rev protein R-HSA-180746 4.608385e-03 2.336 0 0
Base Excision Repair R-HSA-73884 4.774206e-03 2.321 0 0
Regulation of TP53 Activity R-HSA-5633007 4.939927e-03 2.306 0 0
Negative regulation of MET activity R-HSA-6807004 5.409315e-03 2.267 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.409315e-03 2.267 0 0
Signaling by AMER1 mutants R-HSA-4839748 5.433304e-03 2.265 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.433304e-03 2.265 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.467883e-03 2.262 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.913334e-03 2.228 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.178764e-03 2.209 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.655164e-03 2.177 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 6.655164e-03 2.177 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 6.457448e-03 2.190 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.457448e-03 2.190 0 0
Pervasive developmental disorders R-HSA-9005895 7.341001e-03 2.134 0 0
Disorders of Nervous System Development R-HSA-9697154 7.341001e-03 2.134 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 7.341001e-03 2.134 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.341001e-03 2.134 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.341001e-03 2.134 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.341001e-03 2.134 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.341001e-03 2.134 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.341001e-03 2.134 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 7.610778e-03 2.119 0 0
Post NMDA receptor activation events R-HSA-438064 7.169378e-03 2.145 0 0
MAP2K and MAPK activation R-HSA-5674135 6.385430e-03 2.195 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.341001e-03 2.134 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 6.457448e-03 2.190 0 0
ISG15 antiviral mechanism R-HSA-1169408 7.732199e-03 2.112 0 0
HCMV Early Events R-HSA-9609690 8.038608e-03 2.095 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.051585e-03 2.094 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.051585e-03 2.094 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.051585e-03 2.094 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.378230e-03 2.077 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 8.378230e-03 2.077 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 8.378230e-03 2.077 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.903435e-03 2.050 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.903435e-03 2.050 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 9.148520e-03 2.039 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 9.148520e-03 2.039 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 9.172787e-03 2.037 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 9.172787e-03 2.037 0 0
Signaling by Hippo R-HSA-2028269 9.240019e-03 2.034 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 9.624420e-03 2.017 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 9.690352e-03 2.014 0 0
ESR-mediated signaling R-HSA-8939211 9.780404e-03 2.010 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.046978e-02 1.980 0 0
Maturation of protein E R-HSA-9694493 1.046978e-02 1.980 0 0
Maturation of protein E R-HSA-9683683 1.046978e-02 1.980 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.062515e-02 1.974 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.066199e-02 1.972 0 0
Viral Infection Pathways R-HSA-9824446 1.123418e-02 1.949 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.155578e-02 1.937 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.195283e-02 1.923 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.195283e-02 1.923 0 0
RAF activation R-HSA-5673000 1.242383e-02 1.906 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.242556e-02 1.906 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.253098e-02 1.902 0 0
Metabolism of non-coding RNA R-HSA-194441 1.255270e-02 1.901 0 0
snRNP Assembly R-HSA-191859 1.255270e-02 1.901 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.258700e-02 1.900 0 0
Pexophagy R-HSA-9664873 1.258700e-02 1.900 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.263523e-02 1.898 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.302473e-02 1.885 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.306136e-02 1.884 0 0
MET interacts with TNS proteins R-HSA-8875513 1.608841e-02 1.793 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.591000e-02 1.798 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.591000e-02 1.798 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.591000e-02 1.798 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 1.591000e-02 1.798 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.491596e-02 1.826 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.488689e-02 1.827 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.444262e-02 1.840 0 0
RET signaling R-HSA-8853659 1.669665e-02 1.777 0 0
Translesion Synthesis by POLH R-HSA-110320 1.426438e-02 1.846 0 0
Rap1 signalling R-HSA-392517 1.426438e-02 1.846 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.491596e-02 1.826 0 0
PLC beta mediated events R-HSA-112043 1.574226e-02 1.803 0 0
G-protein mediated events R-HSA-112040 1.433508e-02 1.844 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.669665e-02 1.777 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.488689e-02 1.827 0 0
Gene expression (Transcription) R-HSA-74160 1.492020e-02 1.826 0 0
Signaling by ERBB2 R-HSA-1227986 1.407799e-02 1.851 0 0
FLT3 signaling in disease R-HSA-9682385 1.669665e-02 1.777 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 1.677145e-02 1.775 0 0
Signaling by APC mutants R-HSA-4839744 1.677145e-02 1.775 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.677145e-02 1.775 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.677145e-02 1.775 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.677145e-02 1.775 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.677145e-02 1.775 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.742088e-02 1.759 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.742088e-02 1.759 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.742088e-02 1.759 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.751007e-02 1.757 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.782030e-02 1.749 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.796591e-02 1.746 0 0
G2/M Transition R-HSA-69275 1.846062e-02 1.734 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.880140e-02 1.726 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.897771e-02 1.722 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.897771e-02 1.722 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.897771e-02 1.722 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.897771e-02 1.722 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.897771e-02 1.722 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.897771e-02 1.722 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.951824e-02 1.710 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.961884e-02 1.707 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.025551e-02 1.693 0 0
TBC/RABGAPs R-HSA-8854214 2.039923e-02 1.690 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.042515e-02 1.690 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.045305e-02 1.689 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.077064e-02 1.683 0 0
Opioid Signalling R-HSA-111885 2.095537e-02 1.679 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.163586e-02 1.665 0 0
Ub-specific processing proteases R-HSA-5689880 2.168152e-02 1.664 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.175857e-02 1.662 0 0
Regulation of PTEN localization R-HSA-8948747 2.175857e-02 1.662 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.178856e-02 1.662 0 0
NF-kB is activated and signals survival R-HSA-209560 2.178856e-02 1.662 0 0
Signaling by AXIN mutants R-HSA-4839735 2.178856e-02 1.662 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.178856e-02 1.662 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.196962e-02 1.658 0 0
Glucose metabolism R-HSA-70326 2.265881e-02 1.645 0 0
RMTs methylate histone arginines R-HSA-3214858 2.306711e-02 1.637 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.340846e-02 1.631 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.340846e-02 1.631 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.340846e-02 1.631 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.340846e-02 1.631 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.372109e-02 1.625 0 0
Disorders of Developmental Biology R-HSA-9675151 2.445416e-02 1.612 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 2.445416e-02 1.612 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.506246e-02 1.601 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.506246e-02 1.601 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.506246e-02 1.601 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.506246e-02 1.601 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.506246e-02 1.601 0 0
Signaling by MET R-HSA-6806834 2.553891e-02 1.593 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 2.577069e-02 1.589 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 2.577069e-02 1.589 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.605144e-02 1.584 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.609370e-02 1.583 0 0
mRNA 3'-end processing R-HSA-72187 2.645938e-02 1.577 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.689656e-02 1.570 0 0
Signaling by NOTCH R-HSA-157118 2.709875e-02 1.567 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.769061e-02 1.558 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.769061e-02 1.558 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.853817e-02 1.545 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 2.853817e-02 1.545 0 0
Type I hemidesmosome assembly R-HSA-446107 2.940679e-02 1.532 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.845905e-02 1.415 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.451900e-02 1.462 0 0
Late endosomal microautophagy R-HSA-9615710 3.296497e-02 1.482 0 0
Centrosome maturation R-HSA-380287 3.121662e-02 1.506 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.587877e-02 1.445 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 3.820993e-02 1.418 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.845905e-02 1.415 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.964741e-02 1.528 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.940679e-02 1.532 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.569213e-02 1.447 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.969379e-02 1.527 0 0
Mitophagy R-HSA-5205647 3.073571e-02 1.512 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.940679e-02 1.532 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.845905e-02 1.415 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.596368e-02 1.444 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.939688e-02 1.532 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.820107e-02 1.418 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.940679e-02 1.532 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.451900e-02 1.462 0 0
Activation of BH3-only proteins R-HSA-114452 3.783714e-02 1.422 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 3.476611e-02 1.459 0 0
FLT3 Signaling R-HSA-9607240 3.200181e-02 1.495 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.555454e-02 1.449 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.940679e-02 1.532 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 2.940679e-02 1.532 0 0
SARS-CoV-2 Infection R-HSA-9694516 2.940260e-02 1.532 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.952484e-02 1.403 0 0
Manipulation of host energy metabolism R-HSA-9636667 3.989346e-02 1.399 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.989346e-02 1.399 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.990604e-02 1.399 0 0
Signaling by EGFR R-HSA-177929 3.990604e-02 1.399 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.990604e-02 1.399 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 4.025370e-02 1.395 0 0
DNA Damage Bypass R-HSA-73893 4.031386e-02 1.395 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.031386e-02 1.395 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.031386e-02 1.395 0 0
G alpha (12/13) signalling events R-HSA-416482 4.031558e-02 1.395 0 0
Neurodegenerative Diseases R-HSA-8863678 4.043864e-02 1.393 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.043864e-02 1.393 0 0
Regulation of signaling by CBL R-HSA-912631 4.225592e-02 1.374 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.230383e-02 1.374 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.230383e-02 1.374 0 0
Nucleotide Excision Repair R-HSA-5696398 4.257633e-02 1.371 0 0
EGFR downregulation R-HSA-182971 4.316975e-02 1.365 0 0
Protein folding R-HSA-391251 4.349361e-02 1.362 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.450042e-02 1.352 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 4.465655e-02 1.350 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 4.488200e-02 1.348 0 0
Long-term potentiation R-HSA-9620244 4.668168e-02 1.331 0 0
S Phase R-HSA-69242 4.772017e-02 1.321 0 0
Regulation of CDH11 function R-HSA-9762292 4.893235e-02 1.310 0 0
PI3K/AKT activation R-HSA-198203 4.893235e-02 1.310 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.893235e-02 1.310 0 0
Chaperonin-mediated protein folding R-HSA-390466 4.896894e-02 1.310 0 0
Signaling by WNT in cancer R-HSA-4791275 4.897571e-02 1.310 0 0
MET promotes cell motility R-HSA-8875878 4.987796e-02 1.302 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.987796e-02 1.302 0 0
HCMV Late Events R-HSA-9610379 5.033193e-02 1.298 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.106383e-02 1.292 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.106383e-02 1.292 0 0
Protein methylation R-HSA-8876725 5.106383e-02 1.292 0 0
p75NTR signals via NF-kB R-HSA-193639 5.106383e-02 1.292 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.106383e-02 1.292 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.106383e-02 1.292 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.256121e-02 1.279 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.256121e-02 1.279 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.256121e-02 1.279 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.256121e-02 1.279 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.270631e-02 1.278 0 0
MITF-M-dependent gene expression R-HSA-9856651 5.327557e-02 1.273 0 0
Metalloprotease DUBs R-HSA-5689901 5.350843e-02 1.272 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 5.413639e-02 1.267 0 0
RNA Polymerase II Transcription R-HSA-73857 5.449525e-02 1.264 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.461302e-02 1.263 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.526561e-02 1.258 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.550066e-02 1.256 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 5.566648e-02 1.254 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 5.566648e-02 1.254 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 5.566648e-02 1.254 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.753367e-02 1.240 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.753367e-02 1.240 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.753367e-02 1.240 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.753367e-02 1.240 0 0
Kinesins R-HSA-983189 5.753367e-02 1.240 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.753367e-02 1.240 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.772564e-02 1.239 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.772564e-02 1.239 0 0
Basigin interactions R-HSA-210991 5.772564e-02 1.239 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.937018e-02 1.226 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.076664e-02 1.216 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.080652e-02 1.216 0 0
Negative regulation of FLT3 R-HSA-9706369 6.080652e-02 1.216 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 6.088130e-02 1.216 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.088130e-02 1.216 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.092839e-02 1.215 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.092839e-02 1.215 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 6.092839e-02 1.215 0 0
HCMV Infection R-HSA-9609646 6.171661e-02 1.210 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.175836e-02 1.209 0 0
Aggrephagy R-HSA-9646399 6.187333e-02 1.208 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.187333e-02 1.208 0 0
UCH proteinases R-HSA-5689603 6.229759e-02 1.206 0 0
Signaling by NOTCH1 R-HSA-1980143 6.229759e-02 1.206 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.264294e-02 1.203 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.595962e-02 1.181 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 9.912947e-02 1.004 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.912947e-02 1.004 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 9.912947e-02 1.004 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 6.630194e-02 1.178 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 6.630194e-02 1.178 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 6.630194e-02 1.178 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.630194e-02 1.178 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 6.630194e-02 1.178 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 6.630194e-02 1.178 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 6.630194e-02 1.178 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 6.630194e-02 1.178 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 6.630194e-02 1.178 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 6.630194e-02 1.178 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 6.630194e-02 1.178 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 6.630194e-02 1.178 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 6.630194e-02 1.178 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 9.690991e-02 1.014 0 0
MET activates PTPN11 R-HSA-8865999 9.690991e-02 1.014 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.408897e-02 1.130 0 0
Activation of RAC1 R-HSA-428540 7.408897e-02 1.130 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 7.152867e-02 1.146 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 8.321686e-02 1.080 0 0
PKA activation R-HSA-163615 9.584823e-02 1.018 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.660143e-02 1.015 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.556267e-02 1.122 0 0
Neutrophil degranulation R-HSA-6798695 8.660708e-02 1.062 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 9.584823e-02 1.018 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.850411e-02 1.164 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 9.404466e-02 1.027 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.556267e-02 1.122 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.556267e-02 1.122 0 0
GPVI-mediated activation cascade R-HSA-114604 8.539130e-02 1.069 0 0
Trafficking of AMPA receptors R-HSA-399719 9.660143e-02 1.015 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.710851e-02 1.113 0 0
Selective autophagy R-HSA-9663891 8.953899e-02 1.048 0 0
PTEN Regulation R-HSA-6807070 6.659298e-02 1.177 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 8.305942e-02 1.081 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 7.710851e-02 1.113 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.863780e-02 1.163 0 0
Oncogene Induced Senescence R-HSA-2559585 7.710851e-02 1.113 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.621467e-02 1.179 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 7.120453e-02 1.147 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 7.408897e-02 1.130 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.408897e-02 1.130 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 9.758456e-02 1.011 0 0
Generic Transcription Pathway R-HSA-212436 9.168405e-02 1.038 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 7.041593e-02 1.152 0 0
tRNA processing in the nucleus R-HSA-6784531 6.804283e-02 1.167 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.100977e-02 1.149 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 7.860461e-02 1.105 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 8.849492e-02 1.053 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.152867e-02 1.146 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.660143e-02 1.015 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 8.356983e-02 1.078 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.869317e-02 1.052 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.869317e-02 1.052 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.617576e-02 1.118 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 9.417409e-02 1.026 0 0
Signaling by NOTCH4 R-HSA-9013694 9.404466e-02 1.027 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 8.509160e-02 1.070 0 0
Ion homeostasis R-HSA-5578775 7.702370e-02 1.113 0 0
IRAK1 recruits IKK complex R-HSA-937039 8.869317e-02 1.052 0 0
VLDLR internalisation and degradation R-HSA-8866427 8.869317e-02 1.052 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 8.869317e-02 1.052 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.850411e-02 1.164 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.305106e-02 1.081 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.702370e-02 1.113 0 0
G1 Phase R-HSA-69236 9.931641e-02 1.003 0 0
Cyclin D associated events in G1 R-HSA-69231 9.931641e-02 1.003 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.006311e-01 0.997 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.006311e-01 0.997 0 0
Orc1 removal from chromatin R-HSA-68949 1.028522e-01 0.988 0 0
G1/S Transition R-HSA-69206 1.034520e-01 0.985 0 0
CD28 dependent Vav1 pathway R-HSA-389359 1.045659e-01 0.981 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.045659e-01 0.981 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.045659e-01 0.981 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.045659e-01 0.981 0 0
Regulated Necrosis R-HSA-5218859 1.066851e-01 0.972 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.066851e-01 0.972 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.070012e-01 0.971 0 0
Autophagy R-HSA-9612973 1.072515e-01 0.970 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.072756e-01 0.969 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.080884e-01 0.966 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.080884e-01 0.966 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.080884e-01 0.966 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.080884e-01 0.966 0 0
Signaling by NTRKs R-HSA-166520 1.090386e-01 0.962 0 0
Interleukin-7 signaling R-HSA-1266695 1.093673e-01 0.961 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.093913e-01 0.961 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.093913e-01 0.961 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 1.093913e-01 0.961 0 0
Formation of annular gap junctions R-HSA-196025 1.094373e-01 0.961 0 0
Macroautophagy R-HSA-1632852 1.107990e-01 0.955 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.130869e-01 0.947 0 0
Platelet degranulation R-HSA-114608 1.141886e-01 0.942 0 0
Vesicle-mediated transport R-HSA-5653656 1.144980e-01 0.941 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.172804e-01 0.931 0 0
G-protein beta:gamma signalling R-HSA-397795 1.179747e-01 0.928 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.179747e-01 0.928 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.179747e-01 0.928 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.198039e-01 0.922 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.212920e-01 0.916 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.216281e-01 0.915 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.216281e-01 0.915 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.218421e-01 0.914 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.218421e-01 0.914 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.218421e-01 0.914 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 1.218421e-01 0.914 0 0
PCP/CE pathway R-HSA-4086400 1.220167e-01 0.914 0 0
Generation of second messenger molecules R-HSA-202433 1.234680e-01 0.908 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 1.234680e-01 0.908 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 1.238071e-01 0.907 0 0
Signal transduction by L1 R-HSA-445144 1.238071e-01 0.907 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 1.238071e-01 0.907 0 0
Hedgehog 'off' state R-HSA-5610787 1.265198e-01 0.898 0 0
Signaling by TGFB family members R-HSA-9006936 1.273895e-01 0.895 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.291892e-01 0.889 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 1.295066e-01 0.888 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.306263e-01 0.884 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.306263e-01 0.884 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.306263e-01 0.884 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 1.306263e-01 0.884 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.306263e-01 0.884 0 0
MTF1 activates gene expression R-HSA-5660489 1.306263e-01 0.884 0 0
Signaling by Interleukins R-HSA-449147 1.308696e-01 0.883 0 0
ARMS-mediated activation R-HSA-170984 1.320715e-01 0.879 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.320715e-01 0.879 0 0
Gap junction degradation R-HSA-190873 1.320715e-01 0.879 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.320715e-01 0.879 0 0
Unwinding of DNA R-HSA-176974 1.320715e-01 0.879 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.341845e-01 0.872 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.341845e-01 0.872 0 0
Cristae formation R-HSA-8949613 1.349831e-01 0.870 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.349831e-01 0.870 0 0
GPER1 signaling R-HSA-9634597 1.368954e-01 0.864 0 0
Co-stimulation by CD28 R-HSA-389356 1.368954e-01 0.864 0 0
NGF-stimulated transcription R-HSA-9031628 1.368954e-01 0.864 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.382579e-01 0.859 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.383911e-01 0.859 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.383911e-01 0.859 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 1.383911e-01 0.859 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.390497e-01 0.857 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.390497e-01 0.857 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.390497e-01 0.857 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.390497e-01 0.857 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.390497e-01 0.857 0 0
DCC mediated attractive signaling R-HSA-418885 1.397896e-01 0.855 0 0
Translesion synthesis by REV1 R-HSA-110312 1.397896e-01 0.855 0 0
Death Receptor Signaling R-HSA-73887 1.412086e-01 0.850 0 0
Dual Incision in GG-NER R-HSA-5696400 1.415788e-01 0.849 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.884376e-01 0.725 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.884376e-01 0.725 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.884376e-01 0.725 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.884376e-01 0.725 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.884376e-01 0.725 0 0
Mitochondrial transcription initiation R-HSA-163282 2.688968e-01 0.570 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 2.688968e-01 0.570 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.688968e-01 0.570 0 0
Defective GFPT1 causes CMSTA1 R-HSA-4085023 2.688968e-01 0.570 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.688968e-01 0.570 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.665349e-01 0.778 0 0
IRS activation R-HSA-74713 1.665349e-01 0.778 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.665349e-01 0.778 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.038704e-01 0.691 0 0
2-LTR circle formation R-HSA-164843 1.561656e-01 0.806 0 0
Signaling by LTK in cancer R-HSA-9842640 2.419975e-01 0.616 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.419975e-01 0.616 0 0
Translesion synthesis by POLI R-HSA-5656121 1.589525e-01 0.799 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.803927e-01 0.552 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.803927e-01 0.552 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 2.803927e-01 0.552 0 0
SOS-mediated signalling R-HSA-112412 2.803927e-01 0.552 0 0
Recycling of eIF2:GDP R-HSA-72731 2.803927e-01 0.552 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.803927e-01 0.552 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.790126e-01 0.747 0 0
Translesion synthesis by POLK R-HSA-5655862 1.790126e-01 0.747 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.349012e-01 0.629 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.349012e-01 0.629 0 0
Notch-HLH transcription pathway R-HSA-350054 1.718044e-01 0.765 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.718044e-01 0.765 0 0
HIV elongation arrest and recovery R-HSA-167287 1.487604e-01 0.828 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.487604e-01 0.828 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.213926e-01 0.655 0 0
DAP12 signaling R-HSA-2424491 1.780871e-01 0.749 0 0
Activation of the pre-replicative complex R-HSA-68962 1.780871e-01 0.749 0 0
Deadenylation of mRNA R-HSA-429947 2.071915e-01 0.684 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 2.660578e-01 0.575 0 0
Integrin signaling R-HSA-354192 2.259198e-01 0.646 0 0
Dual incision in TC-NER R-HSA-6782135 1.580790e-01 0.801 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.640847e-01 0.578 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.640847e-01 0.578 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.240260e-01 0.650 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.838000e-01 0.547 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.838000e-01 0.547 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 2.598679e-01 0.585 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.771084e-01 0.752 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.633404e-01 0.579 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.779729e-01 0.556 0 0
Transcription of the HIV genome R-HSA-167172 2.748706e-01 0.561 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.998624e-01 0.699 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.240260e-01 0.650 0 0
Integration of provirus R-HSA-162592 2.078051e-01 0.682 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.487604e-01 0.828 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.631407e-01 0.787 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 1.814439e-01 0.741 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.926108e-01 0.715 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.598679e-01 0.585 0 0
G-protein activation R-HSA-202040 2.889794e-01 0.539 0 0
Regulation of Apoptosis R-HSA-169911 1.541704e-01 0.812 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.259198e-01 0.646 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.470374e-01 0.833 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.631407e-01 0.787 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.665349e-01 0.778 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 2.625656e-01 0.581 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 2.889794e-01 0.539 0 0
Developmental Cell Lineages R-HSA-9734767 1.773001e-01 0.751 0 0
TNF signaling R-HSA-75893 2.300395e-01 0.638 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.503221e-01 0.823 0 0
Degradation of CDH1 R-HSA-9766229 1.472998e-01 0.832 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.980383e-01 0.703 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.698744e-01 0.569 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.884376e-01 0.725 0 0
Inositol transporters R-HSA-429593 1.665349e-01 0.778 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 2.038704e-01 0.691 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 2.803927e-01 0.552 0 0
DARPP-32 events R-HSA-180024 1.631407e-01 0.787 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.569690e-01 0.804 0 0
DNA strand elongation R-HSA-69190 2.095191e-01 0.679 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 1.942673e-01 0.712 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 2.391725e-01 0.621 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.391725e-01 0.621 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.773237e-01 0.557 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.773237e-01 0.557 0 0
Synthesis of DNA R-HSA-69239 2.669033e-01 0.574 0 0
MTOR signalling R-HSA-165159 2.703840e-01 0.568 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.209772e-01 0.656 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.349012e-01 0.629 0 0
mTORC1-mediated signalling R-HSA-166208 1.718044e-01 0.765 0 0
Degradation of AXIN R-HSA-4641257 1.808157e-01 0.743 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.174603e-01 0.663 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 2.038704e-01 0.691 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.814865e-01 0.741 0 0
Stabilization of p53 R-HSA-69541 2.092299e-01 0.679 0 0
TCR signaling R-HSA-202403 2.127661e-01 0.672 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.450895e-01 0.611 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 2.863811e-01 0.543 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.550675e-01 0.809 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.434937e-01 0.614 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.926108e-01 0.715 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.859124e-01 0.544 0 0
Mismatch Repair R-HSA-5358508 2.213926e-01 0.655 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 1.631407e-01 0.787 0 0
Rab regulation of trafficking R-HSA-9007101 1.495652e-01 0.825 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.884376e-01 0.725 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.688968e-01 0.570 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 2.803927e-01 0.552 0 0
Signaling by LTK R-HSA-9842663 2.349012e-01 0.629 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.213926e-01 0.655 0 0
PKA activation in glucagon signalling R-HSA-164378 2.213926e-01 0.655 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 2.838000e-01 0.547 0 0
Regulation of insulin secretion R-HSA-422356 1.741756e-01 0.759 0 0
Signaling by Hedgehog R-HSA-5358351 2.720516e-01 0.565 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.277708e-01 0.643 0 0
Signaling by FGFR4 R-HSA-5654743 2.863811e-01 0.543 0 0
Hedgehog 'on' state R-HSA-5632684 2.088949e-01 0.680 0 0
Integration of energy metabolism R-HSA-163685 1.847748e-01 0.733 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.942673e-01 0.712 0 0
NRAGE signals death through JNK R-HSA-193648 2.300395e-01 0.638 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.803927e-01 0.552 0 0
CHL1 interactions R-HSA-447041 2.803927e-01 0.552 0 0
Protein hydroxylation R-HSA-9629569 2.660578e-01 0.575 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.427179e-01 0.615 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.598679e-01 0.585 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.598679e-01 0.585 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.779729e-01 0.556 0 0
Cilium Assembly R-HSA-5617833 2.738006e-01 0.563 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.540399e-01 0.812 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.807869e-01 0.552 0 0
Mitochondrial biogenesis R-HSA-1592230 2.158634e-01 0.666 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.255878e-01 0.647 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.589525e-01 0.799 0 0
MAP kinase activation R-HSA-450294 1.902516e-01 0.721 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.038704e-01 0.691 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.419975e-01 0.616 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.892000e-01 0.723 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.245433e-01 0.649 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.434937e-01 0.614 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.942673e-01 0.712 0 0
Signal regulatory protein family interactions R-HSA-391160 2.906031e-01 0.537 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.814439e-01 0.741 0 0
Gluconeogenesis R-HSA-70263 2.348167e-01 0.629 0 0
CASP4 inflammasome assembly R-HSA-9948001 1.561656e-01 0.806 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.718044e-01 0.765 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.598679e-01 0.585 0 0
Syndecan interactions R-HSA-3000170 1.892000e-01 0.723 0 0
Interleukin-2 signaling R-HSA-9020558 1.814865e-01 0.741 0 0
CREB phosphorylation R-HSA-199920 2.419975e-01 0.616 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.803927e-01 0.552 0 0
Sensory processing of sound R-HSA-9659379 2.045024e-01 0.689 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.453566e-01 0.838 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.390117e-01 0.622 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.038704e-01 0.691 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.803927e-01 0.552 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.790126e-01 0.747 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 1.550675e-01 0.809 0 0
Stimuli-sensing channels R-HSA-2672351 2.770442e-01 0.557 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.589525e-01 0.799 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.889794e-01 0.539 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.598679e-01 0.585 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.863811e-01 0.543 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.889794e-01 0.539 0 0
SARS-CoV Infections R-HSA-9679506 1.995915e-01 0.700 0 0
Glycogen metabolism R-HSA-8982491 2.240260e-01 0.650 0 0
Regulation of BACH1 activity R-HSA-9708530 1.589525e-01 0.799 0 0
Non-canonical inflammasome activation R-HSA-9686114 2.906031e-01 0.537 0 0
Glycogen storage diseases R-HSA-3229121 1.998624e-01 0.699 0 0
Glycogen synthesis R-HSA-3322077 2.660578e-01 0.575 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.928172e-01 0.533 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.928172e-01 0.533 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.950392e-01 0.530 0 0
Aquaporin-mediated transport R-HSA-445717 2.974960e-01 0.527 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.991485e-01 0.524 0 0
Interleukin-17 signaling R-HSA-448424 3.009382e-01 0.522 0 0
mRNA Capping R-HSA-72086 3.037805e-01 0.517 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.037805e-01 0.517 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.037805e-01 0.517 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.038197e-01 0.517 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 3.078465e-01 0.512 0 0
Assembly Of The HIV Virion R-HSA-175474 3.121568e-01 0.506 0 0
Degradation of DVL R-HSA-4641258 3.129683e-01 0.504 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.129683e-01 0.504 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.142008e-01 0.503 0 0
Signaling by FGFR2 R-HSA-5654738 3.160551e-01 0.500 0 0
PKR-mediated signaling R-HSA-9833482 3.160551e-01 0.500 0 0
Cellular response to chemical stress R-HSA-9711123 3.185532e-01 0.497 0 0
RSK activation R-HSA-444257 3.186286e-01 0.497 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.186286e-01 0.497 0 0
MET receptor recycling R-HSA-8875656 3.186286e-01 0.497 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.186286e-01 0.497 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.186286e-01 0.497 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.186286e-01 0.497 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 3.186286e-01 0.497 0 0
Adrenoceptors R-HSA-390696 3.186286e-01 0.497 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.188331e-01 0.496 0 0
G beta:gamma signalling through BTK R-HSA-8964315 3.188331e-01 0.496 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 3.188331e-01 0.496 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 3.189869e-01 0.496 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 3.189869e-01 0.496 0 0
Signaling by FGFR3 R-HSA-5654741 3.189869e-01 0.496 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.239616e-01 0.490 0 0
Interleukin-37 signaling R-HSA-9008059 3.239616e-01 0.490 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.257702e-01 0.487 0 0
Signaling by PTK6 R-HSA-8848021 3.257702e-01 0.487 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.297098e-01 0.482 0 0
FGFR2 alternative splicing R-HSA-6803529 3.354927e-01 0.474 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.354927e-01 0.474 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 3.355270e-01 0.474 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.355270e-01 0.474 0 0
G alpha (z) signalling events R-HSA-418597 3.383528e-01 0.471 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.394597e-01 0.469 0 0
Ca2+ pathway R-HSA-4086398 3.410935e-01 0.467 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.413835e-01 0.467 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.413835e-01 0.467 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.413835e-01 0.467 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.413835e-01 0.467 0 0
Essential pentosuria R-HSA-5662853 3.413835e-01 0.467 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.413835e-01 0.467 0 0
Transcription from mitochondrial promoters R-HSA-75944 3.413835e-01 0.467 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.413835e-01 0.467 0 0
Budding and maturation of HIV virion R-HSA-162588 3.442806e-01 0.463 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.442806e-01 0.463 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.470909e-01 0.460 0 0
Prolonged ERK activation events R-HSA-169893 3.470909e-01 0.460 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.470909e-01 0.460 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.492868e-01 0.457 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.492868e-01 0.457 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.492868e-01 0.457 0 0
Plasma lipoprotein clearance R-HSA-8964043 3.492868e-01 0.457 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.521802e-01 0.453 0 0
Calcineurin activates NFAT R-HSA-2025928 3.563595e-01 0.448 0 0
ALK mutants bind TKIs R-HSA-9700645 3.563595e-01 0.448 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.563595e-01 0.448 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.563595e-01 0.448 0 0
WNT mediated activation of DVL R-HSA-201688 3.563595e-01 0.448 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.563595e-01 0.448 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.563595e-01 0.448 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.563595e-01 0.448 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.563595e-01 0.448 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.563595e-01 0.448 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.588951e-01 0.445 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.588951e-01 0.445 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.588951e-01 0.445 0 0
MHC class II antigen presentation R-HSA-2132295 3.604520e-01 0.443 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.620073e-01 0.441 0 0
HIV Transcription Elongation R-HSA-167169 3.675880e-01 0.435 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.675880e-01 0.435 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.683735e-01 0.434 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.689132e-01 0.433 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 3.752277e-01 0.426 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 3.752277e-01 0.426 0 0
Protein-protein interactions at synapses R-HSA-6794362 3.804143e-01 0.420 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.822773e-01 0.418 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.822773e-01 0.418 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 3.850927e-01 0.414 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 3.850927e-01 0.414 0 0
Nuclear RNA decay R-HSA-9930044 3.850927e-01 0.414 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.850927e-01 0.414 0 0
Cardiogenesis R-HSA-9733709 3.850927e-01 0.414 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.850927e-01 0.414 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.933100e-01 0.405 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 3.933100e-01 0.405 0 0
Signal attenuation R-HSA-74749 3.933100e-01 0.405 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.933100e-01 0.405 0 0
Signaling by Leptin R-HSA-2586552 3.933100e-01 0.405 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.031106e-01 0.395 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 4.031106e-01 0.395 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.031106e-01 0.395 0 0
Degradation of CRY and PER proteins R-HSA-9932298 4.042634e-01 0.393 0 0
Signaling by FGFR1 in disease R-HSA-5655302 4.042634e-01 0.393 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.054726e-01 0.392 0 0
Miscellaneous transport and binding events R-HSA-5223345 4.054726e-01 0.392 0 0
Acyl chain remodelling of PS R-HSA-1482801 4.055587e-01 0.392 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.055587e-01 0.392 0 0
Axonal growth stimulation R-HSA-209563 4.066872e-01 0.391 0 0
MET activates STAT3 R-HSA-8875791 4.066872e-01 0.391 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.066872e-01 0.391 0 0
Intracellular oxygen transport R-HSA-8981607 4.066872e-01 0.391 0 0
Histamine receptors R-HSA-390650 4.066872e-01 0.391 0 0
Interferon Signaling R-HSA-913531 4.088859e-01 0.388 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.127787e-01 0.384 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.172119e-01 0.380 0 0
Pyruvate metabolism R-HSA-70268 4.196561e-01 0.377 0 0
Signal amplification R-HSA-392518 4.257645e-01 0.371 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.257645e-01 0.371 0 0
Signaling by NOTCH2 R-HSA-1980145 4.257645e-01 0.371 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 4.286651e-01 0.368 0 0
Myogenesis R-HSA-525793 4.286651e-01 0.368 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.286651e-01 0.368 0 0
TRP channels R-HSA-3295583 4.286651e-01 0.368 0 0
Suppression of phagosomal maturation R-HSA-9637687 4.286651e-01 0.368 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.292640e-01 0.367 0 0
LGI-ADAM interactions R-HSA-5682910 4.292640e-01 0.367 0 0
Bicarbonate transporters R-HSA-425381 4.292640e-01 0.367 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 4.292640e-01 0.367 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.292640e-01 0.367 0 0
PECAM1 interactions R-HSA-210990 4.292640e-01 0.367 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.292640e-01 0.367 0 0
GAB1 signalosome R-HSA-180292 4.306224e-01 0.366 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.306224e-01 0.366 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.306224e-01 0.366 0 0
Platelet sensitization by LDL R-HSA-432142 4.306224e-01 0.366 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.315607e-01 0.365 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.360088e-01 0.361 0 0
Neurexins and neuroligins R-HSA-6794361 4.360088e-01 0.361 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.360088e-01 0.361 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.419506e-01 0.355 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.459194e-01 0.351 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.485469e-01 0.348 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.515283e-01 0.345 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.515283e-01 0.345 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 4.515283e-01 0.345 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.515283e-01 0.345 0 0
Insulin processing R-HSA-264876 4.515283e-01 0.345 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 4.515283e-01 0.345 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.526736e-01 0.344 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 4.576606e-01 0.339 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 4.576606e-01 0.339 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 4.576606e-01 0.339 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.576606e-01 0.339 0 0
Maturation of nucleoprotein R-HSA-9694631 4.576606e-01 0.339 0 0
DAP12 interactions R-HSA-2172127 4.588738e-01 0.338 0 0
Netrin-1 signaling R-HSA-373752 4.588738e-01 0.338 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 4.640560e-01 0.333 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.640560e-01 0.333 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.640560e-01 0.333 0 0
Sodium/Calcium exchangers R-HSA-425561 4.640560e-01 0.333 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.640560e-01 0.333 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.655193e-01 0.332 0 0
HCN channels R-HSA-1296061 4.655193e-01 0.332 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.655193e-01 0.332 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.655193e-01 0.332 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.655193e-01 0.332 0 0
Regulation of gap junction activity R-HSA-191650 4.655193e-01 0.332 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.655193e-01 0.332 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.655193e-01 0.332 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.655193e-01 0.332 0 0
NADE modulates death signalling R-HSA-205025 4.655193e-01 0.332 0 0
RUNX2 regulates bone development R-HSA-8941326 4.658917e-01 0.332 0 0
G1/S-Specific Transcription R-HSA-69205 4.658917e-01 0.332 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.692390e-01 0.329 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.740864e-01 0.324 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.768269e-01 0.322 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.768269e-01 0.322 0 0
Circadian clock R-HSA-9909396 4.780945e-01 0.320 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.841370e-01 0.315 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.841370e-01 0.315 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 4.841370e-01 0.315 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 4.841370e-01 0.315 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 4.841370e-01 0.315 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 4.841370e-01 0.315 0 0
Formation of definitive endoderm R-HSA-9823730 4.841370e-01 0.315 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.841370e-01 0.315 0 0
Signaling by FGFR in disease R-HSA-1226099 4.853289e-01 0.314 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.856794e-01 0.314 0 0
Signaling by NOTCH3 R-HSA-9012852 4.856794e-01 0.314 0 0
Cellular response to hypoxia R-HSA-1234174 4.931423e-01 0.307 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.946011e-01 0.306 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.962841e-01 0.304 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.975629e-01 0.303 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.975629e-01 0.303 0 0
Polymerase switching R-HSA-69091 4.975629e-01 0.303 0 0
Leading Strand Synthesis R-HSA-69109 4.975629e-01 0.303 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.019705e-01 0.299 0 0
Signaling by FGFR1 R-HSA-5654736 5.019705e-01 0.299 0 0
Ion channel transport R-HSA-983712 5.043113e-01 0.297 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.051227e-01 0.297 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.051227e-01 0.297 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.051227e-01 0.297 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.078717e-01 0.294 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.078717e-01 0.294 0 0
Lagging Strand Synthesis R-HSA-69186 5.099768e-01 0.292 0 0
ERK/MAPK targets R-HSA-198753 5.099768e-01 0.292 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.099768e-01 0.292 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.121674e-01 0.291 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.180718e-01 0.286 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 5.180718e-01 0.286 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.180718e-01 0.286 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.180718e-01 0.286 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.180718e-01 0.286 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.185208e-01 0.285 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.185208e-01 0.285 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.185208e-01 0.285 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 5.185208e-01 0.285 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.185208e-01 0.285 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.185208e-01 0.285 0 0
Reelin signalling pathway R-HSA-8866376 5.185208e-01 0.285 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.185208e-01 0.285 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.185208e-01 0.285 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.185208e-01 0.285 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.185208e-01 0.285 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.185208e-01 0.285 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.187325e-01 0.285 0 0
RAS processing R-HSA-9648002 5.243071e-01 0.280 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.296977e-01 0.276 0 0
Formation of axial mesoderm R-HSA-9796292 5.296977e-01 0.276 0 0
Frs2-mediated activation R-HSA-170968 5.296977e-01 0.276 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.296977e-01 0.276 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.296977e-01 0.276 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.296977e-01 0.276 0 0
Infectious disease R-HSA-5663205 5.342466e-01 0.272 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.351176e-01 0.272 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.351176e-01 0.272 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.394062e-01 0.268 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.413015e-01 0.267 0 0
Interleukin-2 family signaling R-HSA-451927 5.431605e-01 0.265 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.595086e-01 0.252 0 0
Removal of the Flap Intermediate R-HSA-69166 5.604029e-01 0.251 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.604029e-01 0.251 0 0
Regulation of KIT signaling R-HSA-1433559 5.604029e-01 0.251 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.604029e-01 0.251 0 0
HDL assembly R-HSA-8963896 5.604029e-01 0.251 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.604029e-01 0.251 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 5.606741e-01 0.251 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.616540e-01 0.251 0 0
PI3K Cascade R-HSA-109704 5.633605e-01 0.249 0 0
PDE3B signalling R-HSA-165160 5.662693e-01 0.247 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.662693e-01 0.247 0 0
PKB-mediated events R-HSA-109703 5.662693e-01 0.247 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.662693e-01 0.247 0 0
Signaling by RNF43 mutants R-HSA-5340588 5.662693e-01 0.247 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.662693e-01 0.247 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.662693e-01 0.247 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.662693e-01 0.247 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.662693e-01 0.247 0 0
Cam-PDE 1 activation R-HSA-111957 5.662693e-01 0.247 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.662693e-01 0.247 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.662693e-01 0.247 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.662693e-01 0.247 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.662693e-01 0.247 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.662693e-01 0.247 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 5.671213e-01 0.246 0 0
Cardiac conduction R-HSA-5576891 5.698969e-01 0.244 0 0
Translation of Structural Proteins R-HSA-9683701 5.797623e-01 0.237 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 5.798478e-01 0.237 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.804425e-01 0.236 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.813467e-01 0.236 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.813467e-01 0.236 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 5.831092e-01 0.234 0 0
Signaling by FGFR R-HSA-190236 5.849865e-01 0.233 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 5.849865e-01 0.233 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 5.849865e-01 0.233 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 5.849865e-01 0.233 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.954123e-01 0.225 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.974632e-01 0.224 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 6.003391e-01 0.222 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.003391e-01 0.222 0 0
Hemostasis R-HSA-109582 6.056898e-01 0.218 0 0
Thromboxane signalling through TP receptor R-HSA-428930 6.058890e-01 0.218 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.058890e-01 0.218 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.058890e-01 0.218 0 0
Adaptive Immune System R-HSA-1280218 6.063196e-01 0.217 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 6.092851e-01 0.215 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.092851e-01 0.215 0 0
STAT5 Activation R-HSA-9645135 6.092851e-01 0.215 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.092851e-01 0.215 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.092851e-01 0.215 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.092851e-01 0.215 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.092851e-01 0.215 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 6.092851e-01 0.215 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.092851e-01 0.215 0 0
MET Receptor Activation R-HSA-6806942 6.092851e-01 0.215 0 0
Metabolism of vitamin K R-HSA-6806664 6.092851e-01 0.215 0 0
HDL clearance R-HSA-8964011 6.092851e-01 0.215 0 0
VLDL assembly R-HSA-8866423 6.092851e-01 0.215 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.092851e-01 0.215 0 0
Neurofascin interactions R-HSA-447043 6.092851e-01 0.215 0 0
Signaling by SCF-KIT R-HSA-1433557 6.147375e-01 0.211 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.174152e-01 0.209 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.174152e-01 0.209 0 0
Activation of SMO R-HSA-5635838 6.174152e-01 0.209 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.174152e-01 0.209 0 0
Killing mechanisms R-HSA-9664420 6.174152e-01 0.209 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.174152e-01 0.209 0 0
Neddylation R-HSA-8951664 6.193452e-01 0.208 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.195362e-01 0.208 0 0
eNOS activation R-HSA-203615 6.195362e-01 0.208 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.195362e-01 0.208 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.195362e-01 0.208 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 6.206855e-01 0.207 0 0
IGF1R signaling cascade R-HSA-2428924 6.245080e-01 0.204 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.245080e-01 0.204 0 0
G protein gated Potassium channels R-HSA-1296059 6.278256e-01 0.202 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 6.278256e-01 0.202 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 6.278256e-01 0.202 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.278256e-01 0.202 0 0
TGFBR3 expression R-HSA-9839394 6.278256e-01 0.202 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.278256e-01 0.202 0 0
Tight junction interactions R-HSA-420029 6.278256e-01 0.202 0 0
Formation of the nephric duct R-HSA-9830364 6.278256e-01 0.202 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 6.278256e-01 0.202 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 6.278256e-01 0.202 0 0
PERK regulates gene expression R-HSA-381042 6.381431e-01 0.195 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.386106e-01 0.195 0 0
Inositol phosphate metabolism R-HSA-1483249 6.419404e-01 0.193 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.437149e-01 0.191 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.437149e-01 0.191 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.437149e-01 0.191 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.437149e-01 0.191 0 0
Coenzyme A biosynthesis R-HSA-196783 6.437149e-01 0.191 0 0
Passive transport by Aquaporins R-HSA-432047 6.437149e-01 0.191 0 0
Response to metal ions R-HSA-5660526 6.437149e-01 0.191 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 6.463211e-01 0.190 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 6.480370e-01 0.188 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 6.480370e-01 0.188 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 6.480370e-01 0.188 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.480370e-01 0.188 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.480370e-01 0.188 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.480370e-01 0.188 0 0
Disinhibition of SNARE formation R-HSA-114516 6.480370e-01 0.188 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.480370e-01 0.188 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.480370e-01 0.188 0 0
LDL remodeling R-HSA-8964041 6.480370e-01 0.188 0 0
VLDL clearance R-HSA-8964046 6.480370e-01 0.188 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.480370e-01 0.188 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.480370e-01 0.188 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.480370e-01 0.188 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.480370e-01 0.188 0 0
MET activates PTK2 signaling R-HSA-8874081 6.489048e-01 0.188 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.489048e-01 0.188 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.489048e-01 0.188 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.496204e-01 0.187 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 6.571775e-01 0.182 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.587986e-01 0.181 0 0
Diseases of DNA repair R-HSA-9675135 6.638520e-01 0.178 0 0
RSV-host interactions R-HSA-9833110 6.649087e-01 0.177 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.685637e-01 0.175 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.685637e-01 0.175 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.685637e-01 0.175 0 0
Choline catabolism R-HSA-6798163 6.685637e-01 0.175 0 0
Specification of primordial germ cells R-HSA-9827857 6.685637e-01 0.175 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 6.685637e-01 0.175 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.688037e-01 0.175 0 0
Parasite infection R-HSA-9664407 6.688037e-01 0.175 0 0
Leishmania phagocytosis R-HSA-9664417 6.688037e-01 0.175 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 6.691191e-01 0.174 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.691191e-01 0.174 0 0
Signaling by BMP R-HSA-201451 6.691191e-01 0.174 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.691191e-01 0.174 0 0
Adipogenesis R-HSA-9843745 6.699992e-01 0.174 0 0
IRS-mediated signalling R-HSA-112399 6.715356e-01 0.173 0 0
Potential therapeutics for SARS R-HSA-9679191 6.767662e-01 0.170 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 6.783878e-01 0.169 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.829474e-01 0.166 0 0
phospho-PLA2 pathway R-HSA-111995 6.829474e-01 0.166 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 6.829474e-01 0.166 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.829474e-01 0.166 0 0
Regulation by c-FLIP R-HSA-3371378 6.829474e-01 0.166 0 0
Co-stimulation by ICOS R-HSA-9927354 6.829474e-01 0.166 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.829474e-01 0.166 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 6.829474e-01 0.166 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.829474e-01 0.166 0 0
Dimerization of procaspase-8 R-HSA-69416 6.829474e-01 0.166 0 0
Sodium/Proton exchangers R-HSA-425986 6.829474e-01 0.166 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.829474e-01 0.166 0 0
Interleukin-23 signaling R-HSA-9020933 6.829474e-01 0.166 0 0
Telomere Extension By Telomerase R-HSA-171319 6.884672e-01 0.162 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 6.884672e-01 0.162 0 0
Pyroptosis R-HSA-5620971 6.884672e-01 0.162 0 0
Polo-like kinase mediated events R-HSA-156711 6.919904e-01 0.160 0 0
Synaptic adhesion-like molecules R-HSA-8849932 6.919904e-01 0.160 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 6.919904e-01 0.160 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.919904e-01 0.160 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 6.919904e-01 0.160 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.919904e-01 0.160 0 0
ER-Phagosome pathway R-HSA-1236974 6.932335e-01 0.159 0 0
Extension of Telomeres R-HSA-180786 6.990775e-01 0.155 0 0
Protein localization R-HSA-9609507 7.027027e-01 0.153 0 0
Downstream TCR signaling R-HSA-202424 7.043315e-01 0.152 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.063865e-01 0.151 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.064583e-01 0.151 0 0
Signaling by Erythropoietin R-HSA-9006335 7.069531e-01 0.151 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.069531e-01 0.151 0 0
Glucagon-type ligand receptors R-HSA-420092 7.069531e-01 0.151 0 0
Gap junction trafficking and regulation R-HSA-157858 7.087007e-01 0.150 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.087007e-01 0.150 0 0
FOXO-mediated transcription R-HSA-9614085 7.103674e-01 0.149 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.140327e-01 0.146 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.140327e-01 0.146 0 0
The NLRP3 inflammasome R-HSA-844456 7.140327e-01 0.146 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.140327e-01 0.146 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.143971e-01 0.146 0 0
Lipophagy R-HSA-9613354 7.143971e-01 0.146 0 0
CASP8 activity is inhibited R-HSA-5218900 7.143971e-01 0.146 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.143971e-01 0.146 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.143971e-01 0.146 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 7.143971e-01 0.146 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.143971e-01 0.146 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.143971e-01 0.146 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.143971e-01 0.146 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.143971e-01 0.146 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.143971e-01 0.146 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.162371e-01 0.145 0 0
ABC-family proteins mediated transport R-HSA-382556 7.205636e-01 0.142 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 7.219873e-01 0.141 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.219873e-01 0.141 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.219873e-01 0.141 0 0
Interleukin-1 signaling R-HSA-9020702 7.305240e-01 0.136 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.310816e-01 0.136 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.310816e-01 0.136 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.347347e-01 0.134 0 0
Creatine metabolism R-HSA-71288 7.347347e-01 0.134 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 7.368984e-01 0.133 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.368984e-01 0.133 0 0
Mitochondrial protein import R-HSA-1268020 7.373969e-01 0.132 0 0
Heme signaling R-HSA-9707616 7.373969e-01 0.132 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.427288e-01 0.129 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.427288e-01 0.129 0 0
Binding and entry of HIV virion R-HSA-173107 7.427288e-01 0.129 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.427288e-01 0.129 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.427288e-01 0.129 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.427288e-01 0.129 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 7.427288e-01 0.129 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.427288e-01 0.129 0 0
Formation of apoptosome R-HSA-111458 7.427288e-01 0.129 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.491749e-01 0.125 0 0
Signaling by ERBB4 R-HSA-1236394 7.508468e-01 0.124 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.511969e-01 0.124 0 0
HIV Transcription Initiation R-HSA-167161 7.511969e-01 0.124 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.511969e-01 0.124 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.511969e-01 0.124 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.534944e-01 0.123 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.541453e-01 0.123 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.541453e-01 0.123 0 0
Leishmania infection R-HSA-9658195 7.554544e-01 0.122 0 0
Parasitic Infection Pathways R-HSA-9824443 7.554544e-01 0.122 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.558875e-01 0.122 0 0
Mitochondrial protein degradation R-HSA-9837999 7.558875e-01 0.122 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.573310e-01 0.121 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.573310e-01 0.121 0 0
G0 and Early G1 R-HSA-1538133 7.573433e-01 0.121 0 0
Inwardly rectifying K+ channels R-HSA-1296065 7.573433e-01 0.121 0 0
Insulin receptor signalling cascade R-HSA-74751 7.609346e-01 0.119 0 0
Ion transport by P-type ATPases R-HSA-936837 7.609346e-01 0.119 0 0
Iron uptake and transport R-HSA-917937 7.616201e-01 0.118 0 0
tRNA processing R-HSA-72306 7.625091e-01 0.118 0 0
Transmission across Chemical Synapses R-HSA-112315 7.626216e-01 0.118 0 0
Activation of GABAB receptors R-HSA-991365 7.648906e-01 0.116 0 0
GABA B receptor activation R-HSA-977444 7.648906e-01 0.116 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.654026e-01 0.116 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 7.656820e-01 0.116 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.682515e-01 0.114 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.682515e-01 0.114 0 0
vRNP Assembly R-HSA-192905 7.682515e-01 0.114 0 0
Chylomicron assembly R-HSA-8963888 7.682515e-01 0.114 0 0
Synthesis of PI R-HSA-1483226 7.682515e-01 0.114 0 0
Propionyl-CoA catabolism R-HSA-71032 7.682515e-01 0.114 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.682515e-01 0.114 0 0
Vitamin B1 (thiamin) metabolism R-HSA-196819 7.682515e-01 0.114 0 0
Suppression of apoptosis R-HSA-9635465 7.682515e-01 0.114 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.682515e-01 0.114 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.695616e-01 0.114 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 7.708523e-01 0.113 0 0
Serine metabolism R-HSA-977347 7.723170e-01 0.112 0 0
Glutathione synthesis and recycling R-HSA-174403 7.723170e-01 0.112 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 7.725037e-01 0.112 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.725037e-01 0.112 0 0
Interleukin-1 family signaling R-HSA-446652 7.762224e-01 0.110 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.779887e-01 0.109 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.791569e-01 0.108 0 0
Translation of Structural Proteins R-HSA-9694635 7.821448e-01 0.107 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.868791e-01 0.104 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 7.893044e-01 0.103 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 7.893044e-01 0.103 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.893044e-01 0.103 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.893044e-01 0.103 0 0
Gap junction trafficking R-HSA-190828 7.905025e-01 0.102 0 0
Amine ligand-binding receptors R-HSA-375280 7.905025e-01 0.102 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.912436e-01 0.102 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 7.912436e-01 0.102 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.912436e-01 0.102 0 0
Plasmalogen biosynthesis R-HSA-75896 7.912436e-01 0.102 0 0
ERKs are inactivated R-HSA-202670 7.912436e-01 0.102 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.912436e-01 0.102 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.912436e-01 0.102 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.912436e-01 0.102 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 7.912436e-01 0.102 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.912436e-01 0.102 0 0
ABC transporter disorders R-HSA-5619084 7.919008e-01 0.101 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.004926e-01 0.097 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.016175e-01 0.096 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.024444e-01 0.096 0 0
Interleukin receptor SHC signaling R-HSA-912526 8.051638e-01 0.094 0 0
Formation of the ureteric bud R-HSA-9830674 8.051638e-01 0.094 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.051638e-01 0.094 0 0
Growth hormone receptor signaling R-HSA-982772 8.051638e-01 0.094 0 0
MET activates RAS signaling R-HSA-8851805 8.119558e-01 0.090 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.119558e-01 0.090 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.119558e-01 0.090 0 0
Repression of WNT target genes R-HSA-4641265 8.119558e-01 0.090 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.119558e-01 0.090 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.119558e-01 0.090 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.119558e-01 0.090 0 0
Interleukin-15 signaling R-HSA-8983432 8.119558e-01 0.090 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.119558e-01 0.090 0 0
OAS antiviral response R-HSA-8983711 8.119558e-01 0.090 0 0
Signalling to ERKs R-HSA-187687 8.133689e-01 0.090 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.138281e-01 0.089 0 0
Signaling by TGFBR3 R-HSA-9839373 8.138281e-01 0.089 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.172801e-01 0.088 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.172801e-01 0.088 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.199515e-01 0.086 0 0
Complex III assembly R-HSA-9865881 8.199515e-01 0.086 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.199515e-01 0.086 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.199515e-01 0.086 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.253344e-01 0.083 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.255336e-01 0.083 0 0
Triglyceride catabolism R-HSA-163560 8.255336e-01 0.083 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.255336e-01 0.083 0 0
Peroxisomal protein import R-HSA-9033241 8.270457e-01 0.082 0 0
Processing of SMDT1 R-HSA-8949664 8.306141e-01 0.081 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.306141e-01 0.081 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.306141e-01 0.081 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.306141e-01 0.081 0 0
Maturation of nucleoprotein R-HSA-9683610 8.306141e-01 0.081 0 0
Signaling by Insulin receptor R-HSA-74752 8.334232e-01 0.079 0 0
Laminin interactions R-HSA-3000157 8.337242e-01 0.079 0 0
Hyaluronan degradation R-HSA-2160916 8.337242e-01 0.079 0 0
Metal ion SLC transporters R-HSA-425410 8.349801e-01 0.078 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 8.357725e-01 0.078 0 0
tRNA Aminoacylation R-HSA-379724 8.363834e-01 0.078 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.465375e-01 0.072 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 8.465375e-01 0.072 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.465375e-01 0.072 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.465375e-01 0.072 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.474221e-01 0.072 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.474221e-01 0.072 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 8.474221e-01 0.072 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.474221e-01 0.072 0 0
Hydrolysis of LPC R-HSA-1483115 8.474221e-01 0.072 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.474221e-01 0.072 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.474221e-01 0.072 0 0
Physiological factors R-HSA-5578768 8.474221e-01 0.072 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.474221e-01 0.072 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.474221e-01 0.072 0 0
Malate-aspartate shuttle R-HSA-9856872 8.474221e-01 0.072 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.474221e-01 0.072 0 0
Zinc transporters R-HSA-435354 8.474221e-01 0.072 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.538189e-01 0.069 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 8.538189e-01 0.069 0 0
Azathioprine ADME R-HSA-9748787 8.540845e-01 0.068 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.540845e-01 0.068 0 0
Neuronal System R-HSA-112316 8.592839e-01 0.066 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 8.622075e-01 0.064 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 8.625631e-01 0.064 0 0
Erythropoietin activates RAS R-HSA-9027284 8.625631e-01 0.064 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.625631e-01 0.064 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.625631e-01 0.064 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.625631e-01 0.064 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.625631e-01 0.064 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.625631e-01 0.064 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.625631e-01 0.064 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.625631e-01 0.064 0 0
Biotin transport and metabolism R-HSA-196780 8.625631e-01 0.064 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.625631e-01 0.064 0 0
Other semaphorin interactions R-HSA-416700 8.625631e-01 0.064 0 0
DNA Damage Reversal R-HSA-73942 8.625631e-01 0.064 0 0
The phototransduction cascade R-HSA-2514856 8.629107e-01 0.064 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.630232e-01 0.064 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.652981e-01 0.063 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 8.676138e-01 0.062 0 0
Insulin receptor recycling R-HSA-77387 8.695038e-01 0.061 0 0
Inflammasomes R-HSA-622312 8.695038e-01 0.061 0 0
Phosphorylation of the APC/C R-HSA-176412 8.762024e-01 0.057 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.762024e-01 0.057 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.762024e-01 0.057 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.762024e-01 0.057 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.762024e-01 0.057 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.762024e-01 0.057 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.762024e-01 0.057 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.762024e-01 0.057 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.762024e-01 0.057 0 0
Attachment and Entry R-HSA-9678110 8.762024e-01 0.057 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.791965e-01 0.056 0 0
Nucleotide biosynthesis R-HSA-8956320 8.791965e-01 0.056 0 0
Platelet calcium homeostasis R-HSA-418360 8.797616e-01 0.056 0 0
Integrin cell surface interactions R-HSA-216083 8.835936e-01 0.054 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.850887e-01 0.053 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.884889e-01 0.051 0 0
Fibronectin matrix formation R-HSA-1566977 8.884889e-01 0.051 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.884889e-01 0.051 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.884889e-01 0.051 0 0
Formation of xylulose-5-phosphate R-HSA-5661270 8.884889e-01 0.051 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 8.884889e-01 0.051 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.884889e-01 0.051 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.892696e-01 0.051 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.892696e-01 0.051 0 0
Immune System R-HSA-168256 8.909724e-01 0.050 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.937762e-01 0.049 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.980755e-01 0.047 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.995566e-01 0.046 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 8.995566e-01 0.046 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.995566e-01 0.046 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.995566e-01 0.046 0 0
GDP-fucose biosynthesis R-HSA-6787639 8.995566e-01 0.046 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 8.995566e-01 0.046 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.995566e-01 0.046 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.995566e-01 0.046 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.062249e-01 0.043 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.062249e-01 0.043 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.064162e-01 0.043 0 0
Proteasome assembly R-HSA-9907900 9.074478e-01 0.042 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.095264e-01 0.041 0 0
Apoptotic factor-mediated response R-HSA-111471 9.095264e-01 0.041 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.095264e-01 0.041 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 9.095264e-01 0.041 0 0
Tie2 Signaling R-HSA-210993 9.095264e-01 0.041 0 0
Somitogenesis R-HSA-9824272 9.139757e-01 0.039 0 0
Metabolism of proteins R-HSA-392499 9.164689e-01 0.038 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.183646e-01 0.037 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.183646e-01 0.037 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.185072e-01 0.037 0 0
Germ layer formation at gastrulation R-HSA-9754189 9.185072e-01 0.037 0 0
Specification of the neural plate border R-HSA-9834899 9.185072e-01 0.037 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.185072e-01 0.037 0 0
Other interleukin signaling R-HSA-449836 9.185072e-01 0.037 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.193054e-01 0.037 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 9.207262e-01 0.036 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.207262e-01 0.036 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.207262e-01 0.036 0 0
Toll-like Receptor Cascades R-HSA-168898 9.221562e-01 0.035 0 0
GABA receptor activation R-HSA-977443 9.236561e-01 0.034 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.241571e-01 0.034 0 0
Platelet homeostasis R-HSA-418346 9.242426e-01 0.034 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.244526e-01 0.034 0 0
Interferon gamma signaling R-HSA-877300 9.256479e-01 0.034 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.265970e-01 0.033 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.265970e-01 0.033 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.265970e-01 0.033 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.265970e-01 0.033 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.271588e-01 0.033 0 0
Hyaluronan metabolism R-HSA-2142845 9.271588e-01 0.033 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.286371e-01 0.032 0 0
Collagen degradation R-HSA-1442490 9.286371e-01 0.032 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.330959e-01 0.030 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.330959e-01 0.030 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.338841e-01 0.030 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.338841e-01 0.030 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.338841e-01 0.030 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.338841e-01 0.030 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.338841e-01 0.030 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.377281e-01 0.028 0 0
Glycosphingolipid transport R-HSA-9845576 9.385726e-01 0.028 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.385726e-01 0.028 0 0
RNA Polymerase III Transcription R-HSA-74158 9.385726e-01 0.028 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.395423e-01 0.027 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.404482e-01 0.027 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.404482e-01 0.027 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.404482e-01 0.027 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.404482e-01 0.027 0 0
Attachment and Entry R-HSA-9694614 9.404482e-01 0.027 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.410699e-01 0.026 0 0
Disease R-HSA-1643685 9.418816e-01 0.026 0 0
Voltage gated Potassium channels R-HSA-1296072 9.436218e-01 0.025 0 0
Collagen chain trimerization R-HSA-8948216 9.436218e-01 0.025 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.447293e-01 0.025 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.463609e-01 0.024 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.463609e-01 0.024 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.463609e-01 0.024 0 0
Signaling by KIT in disease R-HSA-9669938 9.463609e-01 0.024 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.463609e-01 0.024 0 0
LDL clearance R-HSA-8964038 9.463609e-01 0.024 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.463609e-01 0.024 0 0
SLC transporter disorders R-HSA-5619102 9.480384e-01 0.023 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.481821e-01 0.023 0 0
Elastic fibre formation R-HSA-1566948 9.482743e-01 0.023 0 0
PI Metabolism R-HSA-1483255 9.492836e-01 0.023 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.494009e-01 0.023 0 0
Formation of the cornified envelope R-HSA-6809371 9.499711e-01 0.022 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.505854e-01 0.022 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.512353e-01 0.022 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.516869e-01 0.022 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.516869e-01 0.022 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.516869e-01 0.022 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.525591e-01 0.021 0 0
Pentose phosphate pathway R-HSA-71336 9.525591e-01 0.021 0 0
Signaling by ALK R-HSA-201556 9.525591e-01 0.021 0 0
Kidney development R-HSA-9830369 9.528218e-01 0.021 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.528218e-01 0.021 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 9.564844e-01 0.019 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.564844e-01 0.019 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.564844e-01 0.019 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.565033e-01 0.019 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.568703e-01 0.019 0 0
G alpha (s) signalling events R-HSA-418555 9.588363e-01 0.018 0 0
Collagen formation R-HSA-1474290 9.595955e-01 0.018 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.601201e-01 0.018 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.608057e-01 0.017 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.608057e-01 0.017 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.608057e-01 0.017 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.625686e-01 0.017 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.625686e-01 0.017 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.646981e-01 0.016 0 0
Urea cycle R-HSA-70635 9.646981e-01 0.016 0 0
Sphingolipid catabolism R-HSA-9845614 9.646981e-01 0.016 0 0
Potassium Channels R-HSA-1296071 9.665324e-01 0.015 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.665379e-01 0.015 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.682042e-01 0.014 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.682042e-01 0.014 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.694860e-01 0.013 0 0
Triglyceride metabolism R-HSA-8979227 9.704660e-01 0.013 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.705319e-01 0.013 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.713622e-01 0.013 0 0
RAB geranylgeranylation R-HSA-8873719 9.727137e-01 0.012 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.727137e-01 0.012 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.736748e-01 0.012 0 0
Thyroxine biosynthesis R-HSA-209968 9.742068e-01 0.011 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.742068e-01 0.011 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.753556e-01 0.011 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.765065e-01 0.010 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.765065e-01 0.010 0 0
Signaling by PDGF R-HSA-186797 9.767312e-01 0.010 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.767689e-01 0.010 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 9.767689e-01 0.010 0 0
Neurotransmitter clearance R-HSA-112311 9.767689e-01 0.010 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.767790e-01 0.010 0 0
Innate Immune System R-HSA-168249 9.779018e-01 0.010 0 0
Synthesis of PC R-HSA-1483191 9.785088e-01 0.009 0 0
Cholesterol biosynthesis R-HSA-191273 9.786774e-01 0.009 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.790767e-01 0.009 0 0
Cargo concentration in the ER R-HSA-5694530 9.790767e-01 0.009 0 0
Downstream signal transduction R-HSA-186763 9.790767e-01 0.009 0 0
Intraflagellar transport R-HSA-5620924 9.803452e-01 0.009 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.803452e-01 0.009 0 0
DAG1 glycosylations R-HSA-8931838 9.811554e-01 0.008 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.820290e-01 0.008 0 0
Peptide hormone metabolism R-HSA-2980736 9.829951e-01 0.007 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.830276e-01 0.007 0 0
Extracellular matrix organization R-HSA-1474244 9.833158e-01 0.007 0 0
PPARA activates gene expression R-HSA-1989781 9.854988e-01 0.006 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.856737e-01 0.006 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.862328e-01 0.006 0 0
Gap junction assembly R-HSA-190861 9.862328e-01 0.006 0 0
RA biosynthesis pathway R-HSA-5365859 9.862328e-01 0.006 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.862328e-01 0.006 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.864554e-01 0.006 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.868359e-01 0.006 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.870731e-01 0.006 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.871043e-01 0.006 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.876009e-01 0.005 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.876009e-01 0.005 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.876009e-01 0.005 0 0
COPII-mediated vesicle transport R-HSA-204005 9.878394e-01 0.005 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.899428e-01 0.004 0 0
Lysine catabolism R-HSA-71064 9.899428e-01 0.004 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.909424e-01 0.004 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.911050e-01 0.004 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.911248e-01 0.004 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.912649e-01 0.004 0 0
Dectin-2 family R-HSA-5621480 9.912905e-01 0.004 0 0
Synthesis of PA R-HSA-1483166 9.912905e-01 0.004 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.918426e-01 0.004 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.918426e-01 0.004 0 0
Neurotransmitter release cycle R-HSA-112310 9.920545e-01 0.003 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.926535e-01 0.003 0 0
Diseases of Immune System R-HSA-5260271 9.926535e-01 0.003 0 0
Tryptophan catabolism R-HSA-71240 9.926535e-01 0.003 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.926535e-01 0.003 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.928695e-01 0.003 0 0
Glutathione conjugation R-HSA-156590 9.933835e-01 0.003 0 0
Metabolism of polyamines R-HSA-351202 9.933835e-01 0.003 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.933837e-01 0.003 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.937492e-01 0.003 0 0
Intra-Golgi traffic R-HSA-6811438 9.940415e-01 0.003 0 0
Heme biosynthesis R-HSA-189451 9.940415e-01 0.003 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.941879e-01 0.003 0 0
Complex I biogenesis R-HSA-6799198 9.949813e-01 0.002 0 0
Surfactant metabolism R-HSA-5683826 9.956479e-01 0.002 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 9.968214e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.973811e-01 0.001 0 0
Interferon alpha/beta signaling R-HSA-909733 9.974042e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.974042e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.976148e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.976148e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.978906e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.979095e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.979095e-01 0.001 0 0
Gastrulation R-HSA-9758941 9.985229e-01 0.001 0 0
Paracetamol ADME R-HSA-9753281 9.986253e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.987621e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.987647e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.989759e-01 0.000 0 0
Regulation of beta-cell development R-HSA-186712 9.990961e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.991860e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.992978e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.993204e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.994594e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.995408e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.996482e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.996685e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.997148e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.997432e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.997432e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.997556e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.997669e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.997688e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.997926e-01 0.000 0 0
Keratinization R-HSA-6805567 9.998156e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.998312e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.998316e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.998337e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.998435e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.998629e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.998756e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.998891e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999101e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999155e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999207e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999366e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999567e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999572e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999612e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999683e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999725e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999832e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999870e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999902e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999919e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999951e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999951e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999983e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999985e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999987e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999992e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999994e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999994e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999995e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999996e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999997e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999997e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999998e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999999e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999999e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways