DNAPK

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
O43918 S156 EPSD|PSP AIRE APECED EEARAAAPAALTPRGTASPGsQLKAKPPKKPESSAEQQRLP
O43918 T68 EPSD|PSP AIRE APECED HLKEKEGCPQAFHALLSWLLtQDSTAILDFWRVLFKDYNLE
O96017 T383 EPSD|PSP CHEK2 CDS1 CHK2 RAD53 LIKITDFGHsKILGEtsLMRtLCGtPtyLAPEVLVSVGTAG
O96017 T387 EPSD|PSP CHEK2 CDS1 CHK2 RAD53 TDFGHsKILGEtsLMRtLCGtPtyLAPEVLVSVGTAGYNRA
O96017 T68 SIGNOR|EPSD|PSP CHEK2 CDS1 CHK2 RAD53 NSsQSSHSSSGTLSsLETVStQELYsIPEDQEPEDQEPEEP
P04150 S508 GPS6|SIGNOR|ELM|EPSD NR3C1 GRL LEARKTKKKIKGIQQATTGVsQETSENPGNKtIVPAtLPQL
P04637 S15 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP TP53 P53 ______MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPL
P04637 S20 iPTMNet|EPSD|PSP TP53 P53 _MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQAM
P04637 S33 iPTMNet|EPSD TP53 P53 PLsQEtFsDLWKLLPENNVLsPLPsQAMDDLMLsPDDIEQW
P04637 S37 GPS6|ELM|iPTMNet|EPSD|PSP TP53 P53 EtFsDLWKLLPENNVLsPLPsQAMDDLMLsPDDIEQWFtED
P04637 S46 EPSD|PSP TP53 P53 LPENNVLsPLPsQAMDDLMLsPDDIEQWFtEDPGPDEAPRM
P04637 S9 EPSD|PSP TP53 P53 ____________MEEPQsDPsVEPPLsQEtFsDLWKLLPEN
P04637 T18 iPTMNet|EPSD|PSP TP53 P53 ___MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQ
P05412 S249 GPS6|SIGNOR|ELM|iPTMNet|EPSD JUN PQtVPEMPGEtPPLsPIDMEsQERIKAERKRMRNRIAASKC
P07900 T5 GPS6|SIGNOR|EPSD|PSP HSP90AA1 HSP90A HSPC1 HSPCA ________________MPEEtQtQDQPMEEEEVETFAFQAE
P07900 T7 GPS6|SIGNOR|ELM|EPSD|PSP HSP90AA1 HSP90A HSPC1 HSPCA ______________MPEEtQtQDQPMEEEEVETFAFQAEIA
P07954 T236 SIGNOR|EPSD|PSP FH DALDAKSKEFAQIIKIGRTHtQDAVPLTLGQEFSGYVQQVK
P08670 S430 EPSD|PSP VIM RIsLPLPNFssLNLREtNLDsLPLVDtHsKRTLLIKtVEtR
P08670 S459 EPSD|PSP VIM KRTLLIKtVEtRDGQVINEtsQHHDDLE_____________
P08670 S56 EPSD|PSP VIM RtYsLGsALRPstsRsLyAssPGGVyAtRssAVRLRssVPG
P09874 T594 PSP PARP1 ADPRT PPOL LLEDDKENRYWIFRSWGRVGtVIGSNKLEQMPSKEDAIEHF
P11387 S10 SIGNOR|EPSD|PSP TOP1 ___________MsGDHLHNDsQIEADFRLNDsHKHKDKHKD
P11831 S435 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SRF VMYAPTSGLGDGSLTVLNAFsQAPSTMQVSHsQVQEPGGVP
P11831 S446 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SRF GSLTVLNAFsQAPSTMQVSHsQVQEPGGVPQVFLTASSGTV
P12956 S27 SIGNOR|EPSD|PSP XRCC6 G22P1 YYKtEGDEEAEEEQEENLEAsGDyKYsGRDsLIFLVDASKA
P12956 S33 SIGNOR|EPSD|PSP XRCC6 G22P1 DEEAEEEQEENLEAsGDyKYsGRDsLIFLVDASKAMFEsQS
P12956 S51 GPS6|EPSD|PSP XRCC6 G22P1 KYsGRDsLIFLVDASKAMFEsQSEDELTPFDMSIQCIQSVY
P12956 S6 GPS6|EPSD|PSP XRCC6 G22P1 _______________MsGWEsYYKtEGDEEAEEEQEENLEA
P13010 S577 GPS6|EPSD|PSP XRCC5 G22P2 NHEDGPTAKKLKtEQGGAHFsVssLAEGsVTSVGSVNPAEN
P13010 S580 GPS6|EPSD|PSP XRCC5 G22P2 DGPTAKKLKtEQGGAHFsVssLAEGsVTSVGSVNPAENFRV
P13010 T715 EPSD|PSP XRCC5 G22P2 sVtAEEAKKFLAPKDKPsGDtAAVFEEGGDVDDLLDMI___
P14859 S141 EPSD|PSP POU2F1 OCT1 OTF1 LLLQQAQAQAQLLAAAVQQHsAsQQHsAAGATISASAATPM
P14859 S143 EPSD|PSP POU2F1 OCT1 OTF1 LQQAQAQAQLLAAAVQQHsAsQQHsAAGATISASAATPMtQ
P14859 S147 EPSD|PSP POU2F1 OCT1 OTF1 QAQAQLLAAAVQQHsAsQQHsAAGATISASAATPMtQIPLs
P14859 S167 EPSD|PSP POU2F1 OCT1 OTF1 sAAGATISASAATPMtQIPLsQPIQIAQDLQQLQQLQQQNL
P14859 S232 SIGNOR|EPSD|PSP POU2F1 OCT1 OTF1 PQGQQGLLQAQNLLtQLPQQsQANLLQSQPSITLTSQPATP
P14859 S78 EPSD|PSP POU2F1 OCT1 OTF1 GTSLQAAAQSLNVQSKSNEEsGDsQQPsQPsQQPsVQAAIP
P14859 S81 EPSD|PSP POU2F1 OCT1 OTF1 LQAAAQSLNVQSKSNEEsGDsQQPsQPsQQPsVQAAIPQtQ
P14859 S85 EPSD|PSP POU2F1 OCT1 OTF1 AQSLNVQSKSNEEsGDsQQPsQPsQQPsVQAAIPQtQLMLA
P14859 S88 EPSD|PSP POU2F1 OCT1 OTF1 LNVQSKSNEEsGDsQQPsQPsQQPsVQAAIPQtQLMLAGGQ
P14859 S92 EPSD|PSP POU2F1 OCT1 OTF1 SKSNEEsGDsQQPsQPsQQPsVQAAIPQtQLMLAGGQITGL
P14859 T100 EPSD|PSP POU2F1 OCT1 OTF1 DsQQPsQPsQQPsVQAAIPQtQLMLAGGQITGLTLTPAQQQ
P14859 T162 EPSD|PSP POU2F1 OCT1 OTF1 AsQQHsAAGATISASAATPMtQIPLsQPIQIAQDLQQLQQL
P14859 T226 SIGNOR|EPSD|PSP POU2F1 OCT1 OTF1 FIISQTPQGQQGLLQAQNLLtQLPQQsQANLLQSQPSITLT
P15927 S11 SIGNOR|iPTMNet|EPSD RPA2 REPA2 RPA32 RPA34 __________MWNsGFEsYGsssYGGAGGYtQsPGGFGsPA
P15927 S12 SIGNOR|iPTMNet|EPSD RPA2 REPA2 RPA32 RPA34 _________MWNsGFEsYGsssYGGAGGYtQsPGGFGsPAP
P15927 S13 SIGNOR|iPTMNet|EPSD RPA2 REPA2 RPA32 RPA34 ________MWNsGFEsYGsssYGGAGGYtQsPGGFGsPAPs
P15927 S23 EPSD|PSP RPA2 REPA2 RPA32 RPA34 NsGFEsYGsssYGGAGGYtQsPGGFGsPAPsQAEKKSRARA
P15927 S29 EPSD|PSP RPA2 REPA2 RPA32 RPA34 YGsssYGGAGGYtQsPGGFGsPAPsQAEKKSRARAQHIVPC
P15927 S33 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP RPA2 REPA2 RPA32 RPA34 sYGGAGGYtQsPGGFGsPAPsQAEKKSRARAQHIVPCTIsQ
P15927 S4 iPTMNet|EPSD|PSP RPA2 REPA2 RPA32 RPA34 _________________MWNsGFEsYGsssYGGAGGYtQsP
P15927 S8 iPTMNet|EPSD|PSP RPA2 REPA2 RPA32 RPA34 _____________MWNsGFEsYGsssYGGAGGYtQsPGGFG
P15927 T21 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP RPA2 REPA2 RPA32 RPA34 MWNsGFEsYGsssYGGAGGYtQsPGGFGsPAPsQAEKKSRA
P16104 S140 GPS6|EPSD H2AX H2AFX KtsAtVGPKAPSGGKKAtQAsQEy_________________
P16104 T137 EPSD H2AX H2AFX LPKKtsAtVGPKAPSGGKKAtQAsQEy______________
P16403 T146 SIGNOR|EPSD|PSP H1-2 H1F2 HIST1H1C TKPKKPVGAAKKPKKAAGGAtPKKSAKKTPKKAKKPAAAtV
P17936 S183 EPSD|PSP IGFBP3 IBP3 PKFHPLHSKIIIIKKGHAKDsQRYKVDYESQsTDtQNFssE
P18146 S301 PSP EGR1 KROX24 ZNF225 TQQPSLTPLSTIKAFATQSGsQDLKALNTSYQSQLIKPSRM
P18887 S371 GPS6|EPSD|PSP XRCC1 PDWTRDstHLICAFANtPKYsQVLGLGGRIVRKEWVLDCHR
P19838 S20 EPSD|PSP NFKB1 _MAEDDPYLGRPEQMFHLDPsLTHTIFNPEVFQPQMALPTD
P21980 T162 PSP TGM2 WCPADAVYLDSEEERQEYVLtQQGFIYQGSAKFIKNIPWNF
P22415 S262 EPSD|PSP USF1 BHLHB11 USF GILSKACDyIQELRQSNHRLsEELQGLDQLQLDNDVLRQQV
P23025 S173 iPTMNet|EPSD|PSP XPA XPAC CDLEKREPPLKFIVKKNPHHsQWGDMKLYLKLQIVKRSLEV
P23025 S196 iPTMNet|EPSD|PSP XPA XPAC GDMKLYLKLQIVKRSLEVWGsQEALEEAKEVRQENREKMKQ
P23508 S118 SIGNOR|PSP MCC RLQGTTIREEDEySELRsELsQsQHEVNEDSRSMDQDQTSV
P23508 S120 SIGNOR|PSP MCC QGTTIREEDEySELRsELsQsQHEVNEDSRSMDQDQTSVSI
P24928 S1616 EPSD|PSP POLR2A POLR2 TSPAYEPRSPGGYTPQSPSysPtsPsYsPTsPSYSPTSPNY
P24928 S1621 EPSD|PSP POLR2A POLR2 EPRSPGGYTPQSPSysPtsPsYsPTsPSYSPTSPNYSPTSP
P31270 S98 EPSD|PSP HOXA11 HOX1I NLAHCYsAEELVHRDCLQAPsAAGVPGDVLAKSSANVYHHP
P31270 T119 EPSD|PSP HOXA11 HOX1I AAGVPGDVLAKSSANVYHHPtPAVSSNFYSTVGRNGVLPQA
P31749 S473 GPS6|SIGNOR|EPSD|PSP AKT1 PKB RAC DQDDSMECVDSERRPHFPQFsysAsGtA_____________
P31749 T308 PSP AKT1 PKB RAC IKITDFGLCKEGIKDGAtMKtFCGtPEyLAPEVLEDNDyGR
P35637 S112 EPSD|PSP FUS TLS GQQSSYPGYGQQPAPSSTSGsYGSSsQSSSYGQPQSGSYsQ
P35637 S117 EPSD|PSP FUS TLS YPGYGQQPAPSSTSGsYGSSsQSSSYGQPQSGSYsQQPSYG
P35637 S131 EPSD|PSP FUS TLS GsYGSSsQSSSYGQPQSGSYsQQPSYGGQQQsYGQQQSYNP
P35637 S142 EPSD|PSP FUS TLS YGQPQSGSYsQQPSYGGQQQsYGQQQSYNPPQGYGQQNQYN
P35637 S26 EPSD|PSP FUS TLS YtQQAtQSYGAYPtQPGQGYsQQSsQPYGQQSYSGYsQSTD
P35637 S30 EPSD|PSP FUS TLS AtQSYGAYPtQPGQGYsQQSsQPYGQQSYSGYsQSTDTSGY
P35637 S42 EPSD|PSP FUS TLS GQGYsQQSsQPYGQQSYSGYsQSTDTSGYGQSsYSSYGQsQ
P35637 S54 EPSD|PSP FUS TLS GQQSYSGYsQSTDTSGYGQSsYSSYGQsQNTGYGtQSTPQG
P35637 S61 EPSD|PSP FUS TLS YsQSTDTSGYGQSsYSSYGQsQNTGYGtQSTPQGYGSTGGY
P35637 S84 EPSD|PSP FUS TLS TGYGtQSTPQGYGSTGGYGSsQSsQSSYGQQSSYPGYGQQP
P35637 S87 EPSD|PSP FUS TLS GtQSTPQGYGSTGGYGSsQSsQSSYGQQSSYPGYGQQPAPS
P35637 T11 EPSD|PSP FUS TLS __________MASNDYtQQAtQSYGAYPtQPGQGYsQQSsQ
P35637 T19 EPSD|PSP FUS TLS __MASNDYtQQAtQSYGAYPtQPGQGYsQQSsQPYGQQSYS
P35637 T68 EPSD|PSP FUS TLS SGYGQSsYSSYGQsQNTGYGtQSTPQGYGSTGGYGSsQSsQ
P35637 T7 EPSD|PSP FUS TLS ______________MASNDYtQQAtQSYGAYPtQPGQGYsQ
P42575 S139 SIGNOR|EPSD|PSP CASP2 ICH1 NEDD2 LTTLSGLQHVLPPLSCDYDLsLPFPVCESCPLYKKLRLstD
P46527 S140 EPSD|PSP CDKN1B KIP1 p27 GAPANSEDTHLVDPKTDPsDsQTGLAEQCAGIRKRPAtDDS
P48431 S251 PSP SOX2 GTPGMALGSMGSVVKSEAsssPPVVtSSSHSRAPCQAGDLR
P49917 S668 SIGNOR LIG4 NLtNVNKISNIFEDVEFCVMsGTDsQPKPDLENRIAEFGGY
P49917 S672 SIGNOR LIG4 VNKISNIFEDVEFCVMsGTDsQPKPDLENRIAEFGGYIVQN
P49917 T650 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP LIG4 AAPKMKKVIGIIEHLKAPNLtNVNKISNIFEDVEFCVMsGT
P52945 T11 SIGNOR|EPSD|PSP PDX1 IPF1 STF1 __________MNGEEQYYAAtQLYKDPCAFQRGPAPEFSAs
P54619 S192 SIGNOR|PSP PRKAG1 ILKFLKLFITEFPKPEFMSKsLEELQIGTYANIAMVRTTTP
P54619 T284 SIGNOR|PSP PRKAG1 KALQHRSHYFEGVLKCYLHEtLETIINRLVEAEVHRLVVVD
P55072 S784 EPSD|PSP VCP HEL-220 HEL-S-70 QsRGFGsFRFPsGNQGGAGPsQGsGGGtGGsVYTEDNDDDL
P55895 S365 EPSD|PSP RAG2 FYMLKCAEDDTNEEQTTFTNsQTSTEDPGDSTPFEDSEEFC
P67809 T89 SIGNOR|PSP YBX1 NSEP1 YB1 RNGyGFINRNDtKEDVFVHQtAIKKNNPRKyLRsVGDGEtV
P78527 S2053 GPS6 PRKDC HYRC HYRC1 DSTLSEEMsQFDFSTGVQSYsYSsQDPRPATGRFRRREQRD
P78527 S2056 GPS6|SIGNOR|ELM|EPSD|PSP PRKDC HYRC HYRC1 LSEEMsQFDFSTGVQSYsYSsQDPRPATGRFRRREQRDPTV
P78527 S2612 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP PRKDC HYRC HYRC1 DSDWRFRSTVLtPMFVEtQAsQGtLQtRtQEGsLSARWPVA
P78527 S2624 SIGNOR|iPTMNet|EPSD PRKDC HYRC HYRC1 PMFVEtQAsQGtLQtRtQEGsLSARWPVAGQIRAtQQQHDF
P78527 S3205 SIGNOR|iPTMNet|EPSD|PSP PRKDC HYRC HYRC1 NRCFFLSKIEEKLtPLPEDNsMNVDQDGDPsDRMEVQEQEE
P78527 T2609 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP PRKDC HYRC HYRC1 YTIDSDWRFRSTVLtPMFVEtQAsQGtLQtRtQEGsLSARW
P78527 T2620 GPS6|SIGNOR|ELM|iPTMNet|EPSD PRKDC HYRC HYRC1 TVLtPMFVEtQAsQGtLQtRtQEGsLSARWPVAGQIRAtQQ
P78527 T2638 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP PRKDC HYRC HYRC1 tRtQEGsLSARWPVAGQIRAtQQQHDFtLtQtADGRssFDW
P78527 T2647 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP PRKDC HYRC HYRC1 ARWPVAGQIRAtQQQHDFtLtQtADGRssFDWLTGsstDPL
P78527 T3950 SIGNOR|EPSD|PSP PRKDC HYRC HYRC1 VAMETGGVIGIDFGHAFGSAtQFLPVPELMPFRLTRQFINL
Q00839 S59 SIGNOR|EPSD|PSP HNRNPU C1orf199 HNRPU SAFA U21.1 QAALDDEEAGGRPAMEPGNGsLDLGGDsAGRSGAGLEQEAA
Q01860 S111 PSP POU5F1 OCT3 OCT4 OTF3 ETsQPEGEAGVGVESNSDGAsPEPCTVtPGAVKLEKEKLEQ
Q01860 S93 PSP POU5F1 OCT3 OCT4 OTF3 MAYCGPQVGVGLVPQGGLETsQPEGEAGVGVESNSDGAsPE
Q13426 S260 GPS6|EPSD|PSP XRCC4 QTDLSGLASAAVSKDDsIIssLDVTDIAPSRKRRQRMQRNL
Q13426 S304 EPSD|PSP XRCC4 PKMAPQENQLQEKENsRPDssLPETSKKEHIsAENMsLEtL
Q13426 S320 GPS6|EPSD|PSP XRCC4 RPDssLPETSKKEHIsAENMsLEtLRNssPEDLFDEI____
Q13426 S327 SIGNOR|EPSD|PSP XRCC4 ETSKKEHIsAENMsLEtLRNssPEDLFDEI___________
Q13426 S328 SIGNOR|EPSD|PSP XRCC4 TSKKEHIsAENMsLEtLRNssPEDLFDEI____________
Q14191 S319 EPSD|PSP WRN RECQ3 RECQL2 IIGSTNIETELRPSNNLNLLsFEDSTTGGVQQKQIREHEVL
Q14191 S440 SIGNOR|EPSD|PSP WRN RECQ3 RECQL2 KSTEHLsPNDNENDTSYVIEsDEDLEMEMLKHLSPNDNEND
Q14191 S467 SIGNOR|PSP WRN RECQ3 RECQL2 EMLKHLSPNDNENDTSYVIEsDEDLEMEMLKsLENLNSGTV
Q14653 T135 SIGNOR|EPSD|PSP IRF3 GDFSQPDTsPDTNGGGSTSDtQEDILDELLGNMVLAPLPDP
Q15648 T1457 EPSD|PSP MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2 sGstPKHERGsPsHsKsPAytPQNLDsEsEsGSSIAEKsyQ
Q8IZL8 S1033 PSP PELP1 HMX3 MNAR GtEEERGADTAPTLAPEALPsQGEVEREGEsPAAGPPPQEL
Q8TCS8 S776 SIGNOR|EPSD|PSP PNPT1 PNPASE AtTVVRTLNDRssIVMGEPIsQSSSNsQ_____________
Q96SD1 S503 SIGNOR|EPSD|PSP DCLRE1C ARTEMIS ASCID SCIDA SNM1C DGDVPQWEVFFKRNDEITDEsLENFPSSTVAGGsQsPKLFS
Q96SD1 S516 SIGNOR|EPSD|PSP DCLRE1C ARTEMIS ASCID SCIDA SNM1C NDEITDEsLENFPSSTVAGGsQsPKLFSDsDGESTHISsQN
Q96SD1 S534 EPSD|PSP DCLRE1C ARTEMIS ASCID SCIDA SNM1C GGsQsPKLFSDsDGESTHISsQNSsQSTHITEQGsQGWDsQ
Q96SD1 S538 EPSD|PSP DCLRE1C ARTEMIS ASCID SCIDA SNM1C sPKLFSDsDGESTHISsQNSsQSTHITEQGsQGWDsQSDTV
Q96SD1 S548 EPSD|PSP DCLRE1C ARTEMIS ASCID SCIDA SNM1C ESTHISsQNSsQSTHITEQGsQGWDsQSDTVLLSSQERNSG
Q96SD1 S553 EPSD|PSP DCLRE1C ARTEMIS ASCID SCIDA SNM1C SsQNSsQSTHITEQGsQGWDsQSDTVLLSSQERNSGDITSL
Q96SD1 S645 SIGNOR|EPSD|PSP DCLRE1C ARTEMIS ASCID SCIDA SNM1C SSETHIPEEKSLLNLSTNADsQsssDFEVPstPEAELPKRE
Q96T60 S114 GPS6|SIGNOR|PSP PNKP YLVNGLHPLTLRWEEtRtPEsQPDtPPGtPLVsQDEKRDAE
Q96T60 S126 GPS6|SIGNOR|PSP PNKP WEEtRtPEsQPDtPPGtPLVsQDEKRDAELPKKRMRKsNPG
Q9BPZ7 S186 PSP MAPKAP1 MIP1 SIN1 KGHVGTTATKKIDVYLPLHssQDRLLPMTVVTMAsARVQDL
Q9BPZ7 S343 PSP MAPKAP1 MIP1 SIN1 YRLEKQSEPNVAVDLDSTLEsQSAWEFCLVRENSSRADGVF
Q9BPZ7 S367 PSP MAPKAP1 MIP1 SIN1 WEFCLVRENSSRADGVFEEDsQIDIATVQDMLSSHHYKSFK
Q9BQ15 S134 EPSD|PSP NABP2 OBFC2B SSB1 LP3587 EYStQQAPNKAVQNDSNPSAsQPTTGPSAASPASENQNGNG
Q9H4A6 T143 SIGNOR|EPSD|PSP GOLPH3 GPP34 KSDAPTGDVLLDEALKHVKEtQPPEtVQNWIELLSGETWNP
Q9H4A6 T148 SIGNOR|EPSD|PSP GOLPH3 GPP34 TGDVLLDEALKHVKEtQPPEtVQNWIELLSGETWNPLKLHY
Q9H9Q4 S132 EPSD|PSP NHEJ1 XLF LSGLPFYWNFHCMLASPSLVsQHLIRPLMGMSLALQCQVRE
Q9H9Q4 S245 SIGNOR|EPSD|PSP NHEJ1 XLF EVQVGQKHQGAGDPHTSNSAsLQGIDsQCVNQPEQLVSsAP
Q9H9Q4 S251 EPSD|PSP NHEJ1 XLF KHQGAGDPHTSNSAsLQGIDsQCVNQPEQLVSsAPtLSAPE
Q9H9Q4 S263 EPSD|PSP NHEJ1 XLF SAsLQGIDsQCVNQPEQLVSsAPtLSAPEKESTGTsGPLQR
Q9H9Q4 S55 EPSD|PSP NHEJ1 XLF ALLVSDLQQVWHEQVDTSVVsQRAKELNKRLTAPPAAFLCH
Q9H9Q4 T223 EPSD|PSP NHEJ1 XLF sIGDGKPFVMNLQDLYMAVTtQEVQVGQKHQGAGDPHTSNS
Q9H9Q4 T266 EPSD|PSP NHEJ1 XLF LQGIDsQCVNQPEQLVSsAPtLSAPEKESTGTsGPLQRPQL
Q9NUW8 S81 SIGNOR|EPSD|PSP TDP1 SPVKFSNTDSVLPPKRQKSGsQEDLGWCLSSSDDELQPEMP
Q9UBK2 S636 SIGNOR PPARGC1A LEM6 PGC1 PGC1A PPARGC1 SPLYVRSRSRSPYSRRPRYDsYEEYQHERLKREEYRREYEK
Q9UGP5 T204 SIGNOR|EPSD|PSP POLL EAPNTQAQPISDDEASDGEEtQVSAADLEALISGHYPTSLE
Q9Y294 S192 PSP ASF1A CGI-98 HSPC146 sLLstDALPsAsKGWSTSENsLNVMLESHMDCM________
Q9Y6K9 S43 GPS6|SIGNOR|PSP IKBKG FIP3 NEMO DQDVLGEEsPLGKPAMLHLPsEQGAPETLQRCLEENQELRD
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cell Cycle, Mitotic R-HSA-69278 3.863576e-14 13.413 0 0
Cell Cycle Checkpoints R-HSA-69620 1.830647e-12 11.737 0 0
M Phase R-HSA-68886 3.205313e-10 9.494 0 0
Mitotic Prometaphase R-HSA-68877 3.780638e-09 8.422 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.798017e-09 8.168 1 0
Regulation of TP53 Activity R-HSA-5633007 1.149445e-08 7.940 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.388371e-08 7.857 0 0
G2/M Checkpoints R-HSA-69481 5.064272e-08 7.295 0 0
Homology Directed Repair R-HSA-5693538 2.252405e-07 6.647 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.566801e-07 6.591 0 0
Separation of Sister Chromatids R-HSA-2467813 2.783996e-07 6.555 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.312445e-07 6.480 0 0
Mitotic Anaphase R-HSA-68882 4.112024e-07 6.386 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 4.140714e-07 6.383 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 4.754977e-07 6.323 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.253186e-07 6.280 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 9.315658e-07 6.031 0 0
G2/M Transition R-HSA-69275 1.185156e-06 5.926 0 0
Metabolism of RNA R-HSA-8953854 1.352614e-06 5.869 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.597392e-06 5.797 0 0
Membrane Trafficking R-HSA-199991 1.778778e-06 5.750 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.977555e-06 5.704 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.957714e-06 5.529 0 0
Aggrephagy R-HSA-9646399 4.099124e-06 5.387 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.125859e-06 5.384 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 6.099855e-06 5.215 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 6.099855e-06 5.215 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.697569e-06 5.061 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 9.685541e-06 5.014 0 0
Death Receptor Signaling R-HSA-73887 1.047611e-05 4.980 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.199795e-05 4.921 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.325010e-05 4.878 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.349250e-05 4.870 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.475078e-05 4.831 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.528527e-05 4.816 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.544184e-05 4.811 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.765584e-05 4.753 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.961259e-05 4.707 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.200491e-05 4.657 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.248241e-05 4.648 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.248241e-05 4.648 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 2.201314e-05 4.657 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.260503e-05 4.646 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.681463e-05 4.572 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.884185e-05 4.540 1 1
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.056795e-05 4.515 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.403536e-05 4.468 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.403536e-05 4.468 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.403536e-05 4.468 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.403536e-05 4.468 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 3.522920e-05 4.453 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.602548e-05 4.443 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.641624e-05 4.439 0 0
Signaling by ALK in cancer R-HSA-9700206 3.641624e-05 4.439 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.657375e-05 4.437 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 4.126803e-05 4.384 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.432888e-05 4.353 0 0
Kinesins R-HSA-983189 5.177218e-05 4.286 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.566855e-05 4.254 1 1
mRNA Splicing R-HSA-72172 5.541430e-05 4.256 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.597793e-05 4.252 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.461958e-05 4.263 0 0
DNA Repair R-HSA-73894 7.679201e-05 4.115 1 0
p75 NTR receptor-mediated signalling R-HSA-193704 8.203052e-05 4.086 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.299073e-05 4.081 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 9.240565e-05 4.034 0 0
Selective autophagy R-HSA-9663891 9.240565e-05 4.034 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.867213e-05 4.052 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 9.205528e-05 4.036 0 0
Apoptotic execution phase R-HSA-75153 9.309688e-05 4.031 0 0
Diseases of DNA repair R-HSA-9675135 9.309688e-05 4.031 0 0
DNA Double Strand Break Response R-HSA-5693606 9.435966e-05 4.025 0 0
RET signaling R-HSA-8853659 1.181215e-04 3.928 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.332148e-04 3.875 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.422848e-04 3.847 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.457015e-04 3.837 0 0
FLT3 Signaling R-HSA-9607240 1.570994e-04 3.804 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.716992e-04 3.765 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.680418e-04 3.775 0 0
Post NMDA receptor activation events R-HSA-438064 1.728404e-04 3.762 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.736358e-04 3.760 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.786504e-04 3.748 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.833911e-04 3.737 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.925578e-04 3.715 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.925578e-04 3.715 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.006416e-04 3.698 0 0
Cellular response to heat stress R-HSA-3371556 2.099870e-04 3.678 0 0
Signaling by VEGF R-HSA-194138 2.141192e-04 3.669 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 2.305794e-04 3.637 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.643834e-04 3.578 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.637640e-04 3.579 0 0
Regulation of TNFR1 signaling R-HSA-5357905 2.514255e-04 3.600 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.593943e-04 3.586 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.593943e-04 3.586 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.510282e-04 3.600 0 0
Chromatin organization R-HSA-4839726 2.409177e-04 3.618 0 0
Cellular responses to stimuli R-HSA-8953897 2.632739e-04 3.580 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.741123e-04 3.562 0 0
Axon guidance R-HSA-422475 3.001453e-04 3.523 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.036978e-04 3.518 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 3.077509e-04 3.512 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 3.408318e-04 3.467 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.961134e-04 3.402 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.195898e-04 3.377 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.431714e-04 3.353 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 4.462986e-04 3.350 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.708572e-04 3.327 0 0
Negative regulation of MET activity R-HSA-6807004 4.755398e-04 3.323 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.785945e-04 3.238 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.785945e-04 3.238 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.669008e-04 3.246 0 0
Nuclear import of Rev protein R-HSA-180746 5.786506e-04 3.238 0 0
Signaling by Hippo R-HSA-2028269 5.789469e-04 3.237 0 0
Cellular responses to stress R-HSA-2262752 5.905034e-04 3.229 0 0
Macroautophagy R-HSA-1632852 6.027693e-04 3.220 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.047075e-04 3.218 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.895471e-04 3.161 0 0
p75NTR signals via NF-kB R-HSA-193639 6.895471e-04 3.161 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.895471e-04 3.161 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.895471e-04 3.161 0 0
Autophagy R-HSA-9612973 6.530320e-04 3.185 0 0
SARS-CoV-2-host interactions R-HSA-9705683 6.817641e-04 3.166 0 0
Apoptosis R-HSA-109581 7.173531e-04 3.144 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 7.219131e-04 3.142 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.946646e-04 3.100 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.946646e-04 3.100 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.627952e-04 3.118 0 0
Recycling pathway of L1 R-HSA-437239 8.016506e-04 3.096 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.272901e-04 3.082 0 0
Chaperone Mediated Autophagy R-HSA-9613829 8.272901e-04 3.082 0 0
TNF signaling R-HSA-75893 8.354107e-04 3.078 0 0
Signaling by EGFR R-HSA-177929 8.354107e-04 3.078 0 0
S Phase R-HSA-69242 8.437531e-04 3.074 0 0
MAP kinase activation R-HSA-450294 9.179748e-04 3.037 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.051808e-04 3.043 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.051808e-04 3.043 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.180349e-04 3.037 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 9.674861e-04 3.014 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 9.674861e-04 3.014 0 0
Intracellular signaling by second messengers R-HSA-9006925 9.680637e-04 3.014 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 9.741341e-04 3.011 0 0
Nervous system development R-HSA-9675108 9.825571e-04 3.008 0 0
AURKA Activation by TPX2 R-HSA-8854518 9.921743e-04 3.003 0 0
Deubiquitination R-HSA-5688426 1.093901e-03 2.961 0 0
Cellular Senescence R-HSA-2559583 1.018483e-03 2.992 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.098362e-03 2.959 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.116025e-03 2.952 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.158030e-03 2.936 0 0
Chromatin modifying enzymes R-HSA-3247509 1.169786e-03 2.932 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.204537e-03 2.919 0 0
Notch-HLH transcription pathway R-HSA-350054 1.243927e-03 2.905 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.244902e-03 2.905 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 1.279364e-03 2.893 0 0
Mitotic Prophase R-HSA-68875 1.295915e-03 2.887 0 0
Signal Transduction R-HSA-162582 1.417546e-03 2.848 0 0
snRNP Assembly R-HSA-191859 1.450189e-03 2.839 0 0
Metabolism of non-coding RNA R-HSA-194441 1.450189e-03 2.839 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.488566e-03 2.827 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.576292e-03 2.802 0 0
Gene expression (Transcription) R-HSA-74160 1.669212e-03 2.777 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.726608e-03 2.763 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.770169e-03 2.752 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.018022e-03 2.695 0 0
Oncogene Induced Senescence R-HSA-2559585 1.978429e-03 2.704 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.147063e-03 2.668 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.156165e-03 2.666 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.169785e-03 2.664 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.169785e-03 2.664 0 0
tRNA processing in the nucleus R-HSA-6784531 2.415436e-03 2.617 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 2.530672e-03 2.597 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.620950e-03 2.582 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.037668e-03 2.517 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.851938e-03 2.545 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.763074e-03 2.559 0 0
Semaphorin interactions R-HSA-373755 2.838814e-03 2.547 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 2.784959e-03 2.555 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 2.803273e-03 2.552 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.100877e-03 2.509 0 0
DAG and IP3 signaling R-HSA-1489509 3.100877e-03 2.509 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.116821e-03 2.506 0 0
Vesicle-mediated transport R-HSA-5653656 3.138102e-03 2.503 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 3.322847e-03 2.478 0 0
Interleukin-37 signaling R-HSA-9008059 3.476054e-03 2.459 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.573754e-03 2.447 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.674357e-03 2.435 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.713137e-03 2.430 1 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 3.723563e-03 2.429 0 0
Josephin domain DUBs R-HSA-5689877 3.726184e-03 2.429 0 0
Signaling by ERBB2 R-HSA-1227986 3.738495e-03 2.427 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.773628e-03 2.423 0 0
Interleukin-17 signaling R-HSA-448424 3.976584e-03 2.400 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.281243e-03 2.368 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.281243e-03 2.368 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.457019e-03 2.351 0 0
Centrosome maturation R-HSA-380287 4.049507e-03 2.393 0 0
PKR-mediated signaling R-HSA-9833482 4.096163e-03 2.388 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 4.601074e-03 2.337 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 4.601074e-03 2.337 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 4.601074e-03 2.337 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 4.096163e-03 2.388 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.480142e-03 2.349 0 0
Regulation of PTEN localization R-HSA-8948747 4.222064e-03 2.374 0 0
Programmed Cell Death R-HSA-5357801 4.069287e-03 2.390 0 0
NRAGE signals death through JNK R-HSA-193648 4.201003e-03 2.377 0 0
Signaling by Interleukins R-HSA-449147 4.894163e-03 2.310 0 0
Co-inhibition by CTLA4 R-HSA-389513 4.905058e-03 2.309 0 0
Co-stimulation by CD28 R-HSA-389356 5.279175e-03 2.277 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.297871e-03 2.276 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.522095e-03 2.258 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.725759e-03 2.242 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.900808e-03 2.229 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 6.614171e-03 2.180 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.614171e-03 2.180 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.378173e-03 2.195 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.378173e-03 2.195 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.378173e-03 2.195 0 0
Regulation of necroptotic cell death R-HSA-5675482 6.616098e-03 2.179 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 6.616098e-03 2.179 0 0
RUNX2 regulates bone development R-HSA-8941326 6.037858e-03 2.219 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.002143e-03 2.222 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.889274e-03 2.162 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 6.614171e-03 2.180 0 0
ER to Golgi Anterograde Transport R-HSA-199977 6.533125e-03 2.185 0 0
G alpha (12/13) signalling events R-HSA-416482 6.084051e-03 2.216 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 6.235610e-03 2.205 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.115468e-03 2.214 0 0
Calmodulin induced events R-HSA-111933 6.037858e-03 2.219 0 0
Cilium Assembly R-HSA-5617833 6.665163e-03 2.176 0 0
CaM pathway R-HSA-111997 6.037858e-03 2.219 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.616098e-03 2.179 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.153482e-03 2.145 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.190386e-03 2.143 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 7.190386e-03 2.143 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.295088e-03 2.137 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 7.403947e-03 2.131 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 7.434554e-03 2.129 0 0
Signaling by NOTCH3 R-HSA-9012852 7.571414e-03 2.121 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 7.571414e-03 2.121 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.740343e-03 2.111 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.740343e-03 2.111 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.740343e-03 2.111 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.740343e-03 2.111 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.740343e-03 2.111 0 0
Signaling by MET R-HSA-6806834 7.860420e-03 2.105 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.898569e-03 2.102 0 0
NF-kB is activated and signals survival R-HSA-209560 7.898569e-03 2.102 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.058112e-03 2.094 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 8.419442e-03 2.075 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.419442e-03 2.075 1 1
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 8.447097e-03 2.073 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 8.843403e-03 2.053 0 0
Ca-dependent events R-HSA-111996 9.289726e-03 2.032 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 9.862501e-03 2.006 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.095495e-02 1.960 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.118409e-02 1.951 0 0
Translesion Synthesis by POLH R-HSA-110320 1.090262e-02 1.962 0 0
Metalloprotease DUBs R-HSA-5689901 9.619718e-03 2.017 0 0
EGFR downregulation R-HSA-182971 1.077835e-02 1.967 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.042942e-02 1.982 0 0
Signaling by FGFR4 R-HSA-5654743 1.094683e-02 1.961 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.152825e-02 1.938 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 9.862501e-03 2.006 0 0
Heme signaling R-HSA-9707616 1.025275e-02 1.989 0 0
HIV Life Cycle R-HSA-162587 9.734652e-03 2.012 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.033473e-02 1.986 0 0
Rap1 signalling R-HSA-392517 1.090262e-02 1.962 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.179971e-02 1.928 0 0
CREB phosphorylation R-HSA-199920 1.184095e-02 1.927 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.290448e-02 1.889 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.297648e-02 1.887 0 0
DNA strand elongation R-HSA-69190 1.302468e-02 1.885 0 0
DNA Damage Bypass R-HSA-73893 1.314454e-02 1.881 0 0
RNA Polymerase II Transcription R-HSA-73857 1.325547e-02 1.878 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.385754e-02 1.858 0 0
FLT3 signaling in disease R-HSA-9682385 1.390287e-02 1.857 0 0
Pexophagy R-HSA-9664873 1.411010e-02 1.850 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.411010e-02 1.850 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.445455e-02 1.840 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.453076e-02 1.838 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.456673e-02 1.837 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.456673e-02 1.837 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.478892e-02 1.830 0 0
Signaling by FGFR3 R-HSA-5654741 1.495039e-02 1.825 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.500489e-02 1.824 0 0
Cell-Cell communication R-HSA-1500931 1.549575e-02 1.810 0 0
Ub-specific processing proteases R-HSA-5689880 1.551851e-02 1.809 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.561218e-02 1.807 0 0
MHC class II antigen presentation R-HSA-2132295 1.609563e-02 1.793 0 0
Circadian clock R-HSA-9909396 1.615894e-02 1.792 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.644072e-02 1.784 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.650979e-02 1.782 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.780604e-02 1.749 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.780604e-02 1.749 0 0
PECAM1 interactions R-HSA-210990 1.948962e-02 1.710 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 1.736638e-02 1.760 0 0
Striated Muscle Contraction R-HSA-390522 1.857062e-02 1.731 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.931552e-02 1.714 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.999982e-02 1.699 0 0
mRNA 3'-end processing R-HSA-72187 2.004384e-02 1.698 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.740452e-02 1.759 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.092652e-02 1.679 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.746825e-02 1.758 0 0
Activation of the pre-replicative complex R-HSA-68962 2.092652e-02 1.679 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.949355e-02 1.710 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.780855e-02 1.749 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.948962e-02 1.710 0 0
HDMs demethylate histones R-HSA-3214842 1.944462e-02 1.711 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.929914e-02 1.714 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.948962e-02 1.710 0 0
Activation of BH3-only proteins R-HSA-114452 2.092652e-02 1.679 0 0
G1/S Transition R-HSA-69206 2.087218e-02 1.680 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.740452e-02 1.759 0 0
Host Interactions of HIV factors R-HSA-162909 1.757917e-02 1.755 0 0
Dual Incision in GG-NER R-HSA-5696400 2.192939e-02 1.659 0 0
Signaling by NOTCH2 R-HSA-1980145 2.192939e-02 1.659 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 2.247839e-02 1.648 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 2.247839e-02 1.648 0 0
Stabilization of p53 R-HSA-69541 2.255234e-02 1.647 0 0
Synthesis of DNA R-HSA-69239 2.267004e-02 1.645 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.287587e-02 1.641 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.346173e-02 1.630 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.346173e-02 1.630 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 2.346173e-02 1.630 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.349997e-02 1.629 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.376715e-02 1.624 0 0
Signaling by NOTCH4 R-HSA-9013694 2.385981e-02 1.622 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.491211e-02 1.604 0 0
Processive synthesis on the lagging strand R-HSA-69183 2.515464e-02 1.599 0 0
Translesion synthesis by REV1 R-HSA-110312 2.515464e-02 1.599 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 2.515464e-02 1.599 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 2.515464e-02 1.599 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.515464e-02 1.599 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.547780e-02 1.594 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.611842e-02 1.583 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.611842e-02 1.583 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.611842e-02 1.583 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.617565e-02 1.582 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.624720e-02 1.581 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.624720e-02 1.581 0 0
Degradation of CDH1 R-HSA-9766229 2.624720e-02 1.581 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 2.658868e-02 1.575 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.705074e-02 1.568 0 0
Regulation of PTEN gene transcription R-HSA-8943724 2.881981e-02 1.540 0 0
Regulation of signaling by CBL R-HSA-912631 2.910156e-02 1.536 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.910156e-02 1.536 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 2.929625e-02 1.533 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 2.929625e-02 1.533 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.931213e-02 1.533 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 3.622678e-02 1.441 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 3.622678e-02 1.441 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 3.622678e-02 1.441 0 0
Diseases of Telomere Maintenance R-HSA-9673013 3.622678e-02 1.441 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 3.622678e-02 1.441 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 3.622678e-02 1.441 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 3.622678e-02 1.441 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 3.622678e-02 1.441 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 3.622678e-02 1.441 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 3.943691e-02 1.404 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.943691e-02 1.404 0 0
MET interacts with TNS proteins R-HSA-8875513 3.943691e-02 1.404 0 0
MET activates PTPN11 R-HSA-8865999 3.943691e-02 1.404 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.264428e-02 1.486 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.499289e-02 1.456 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 3.409473e-02 1.467 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 3.409473e-02 1.467 0 0
Disorders of Nervous System Development R-HSA-9697154 3.409473e-02 1.467 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.409473e-02 1.467 0 0
Pervasive developmental disorders R-HSA-9005895 3.409473e-02 1.467 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 3.409473e-02 1.467 0 0
Translesion synthesis by POLI R-HSA-5656121 3.184830e-02 1.497 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.173116e-02 1.499 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.795348e-02 1.421 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 3.795348e-02 1.421 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.338003e-02 1.477 0 0
Late endosomal microautophagy R-HSA-9615710 3.927607e-02 1.406 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.015270e-02 1.521 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.015270e-02 1.521 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 3.234982e-02 1.490 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.020916e-02 1.520 0 0
Adipogenesis R-HSA-9843745 3.635099e-02 1.439 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.315278e-02 1.479 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 3.430305e-02 1.465 0 0
MTOR signalling R-HSA-165159 3.959573e-02 1.402 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 3.717342e-02 1.430 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 3.717342e-02 1.430 0 0
PTEN Regulation R-HSA-6807070 3.059579e-02 1.514 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.264428e-02 1.486 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.499289e-02 1.456 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.499289e-02 1.456 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.467544e-02 1.460 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 2.996149e-02 1.523 0 0
Signaling by FGFR1 in disease R-HSA-5655302 3.467544e-02 1.460 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.392239e-02 1.470 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.015270e-02 1.521 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.468854e-02 1.460 0 0
Interferon Signaling R-HSA-913531 3.191867e-02 1.496 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.795348e-02 1.421 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.264428e-02 1.486 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.264428e-02 1.486 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.052412e-02 1.515 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 3.430305e-02 1.465 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.362347e-02 1.473 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.371990e-02 1.472 0 0
Maturation of protein E R-HSA-9683683 3.264428e-02 1.486 0 0
Maturation of protein E R-HSA-9694493 3.264428e-02 1.486 0 0
Disorders of Developmental Biology R-HSA-9675151 3.963896e-02 1.402 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.963896e-02 1.402 0 0
Translesion synthesis by POLK R-HSA-5655862 3.963896e-02 1.402 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.090040e-02 1.388 0 0
Meiosis R-HSA-1500620 4.204043e-02 1.376 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.291514e-02 1.367 0 0
Lagging Strand Synthesis R-HSA-69186 4.303834e-02 1.366 0 0
ERK/MAPK targets R-HSA-198753 4.303834e-02 1.366 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 4.303834e-02 1.366 0 0
Interleukin-6 signaling R-HSA-1059683 4.349480e-02 1.362 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.349480e-02 1.362 0 0
Signaling by FGFR2 R-HSA-5654738 4.389325e-02 1.358 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.404028e-02 1.356 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.602286e-02 1.337 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.644242e-02 1.333 0 0
Signaling by Leptin R-HSA-2586552 4.644242e-02 1.333 0 0
Signal attenuation R-HSA-74749 4.644242e-02 1.333 0 0
Nef and signal transduction R-HSA-164944 4.670046e-02 1.331 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.670046e-02 1.331 0 0
Hedgehog 'off' state R-HSA-5610787 4.742348e-02 1.324 0 0
Glycolysis R-HSA-70171 4.742348e-02 1.324 0 0
Cell junction organization R-HSA-446728 4.751006e-02 1.323 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.772738e-02 1.321 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.857787e-02 1.314 0 0
Nucleotide Excision Repair R-HSA-5696398 4.892058e-02 1.311 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 4.908495e-02 1.309 0 0
Signaling by NOTCH1 R-HSA-1980143 5.034081e-02 1.298 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.067502e-02 1.295 0 0
Cyclin D associated events in G1 R-HSA-69231 5.087503e-02 1.293 0 0
G1 Phase R-HSA-69236 5.087503e-02 1.293 0 0
Netrin-1 signaling R-HSA-373752 5.087503e-02 1.293 0 0
Signaling by ROBO receptors R-HSA-376176 5.141834e-02 1.289 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.142083e-02 1.289 0 0
Mitochondrial calcium ion transport R-HSA-8949215 5.142083e-02 1.289 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.277726e-02 1.278 0 0
TRP channels R-HSA-3295583 5.277726e-02 1.278 0 0
PERK regulates gene expression R-HSA-381042 5.279987e-02 1.277 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 5.279987e-02 1.277 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 5.313092e-02 1.275 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 5.313092e-02 1.275 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.359487e-02 1.271 0 0
Interleukin-1 family signaling R-HSA-446652 5.402434e-02 1.267 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.437115e-02 1.265 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.437115e-02 1.265 0 0
Removal of the Flap Intermediate R-HSA-69166 5.437115e-02 1.265 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.437115e-02 1.265 0 0
HIV Infection R-HSA-162906 5.495226e-02 1.260 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.547165e-02 1.256 0 0
PLC beta mediated events R-HSA-112043 5.721924e-02 1.242 0 0
Generic Transcription Pathway R-HSA-212436 5.775763e-02 1.238 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.778438e-02 1.238 0 0
Ephrin signaling R-HSA-3928664 5.870198e-02 1.231 0 0
Platelet sensitization by LDL R-HSA-432142 5.870198e-02 1.231 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.956910e-02 1.225 0 0
Signaling by FGFR1 R-HSA-5654736 5.956910e-02 1.225 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.987120e-02 1.223 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.987120e-02 1.223 0 0
Signaling by NTRKs R-HSA-166520 6.062758e-02 1.217 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.113696e-02 1.214 0 0
Regulation of gap junction activity R-HSA-191650 6.127093e-02 1.213 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 6.127093e-02 1.213 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 6.127093e-02 1.213 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 6.127093e-02 1.213 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 6.127093e-02 1.213 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 6.127093e-02 1.213 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.143401e-02 1.212 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.143401e-02 1.212 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.160414e-02 1.210 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 6.318750e-02 1.199 0 0
MECP2 regulates transcription factors R-HSA-9022707 6.361636e-02 1.196 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 7.406795e-02 1.130 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 7.406795e-02 1.130 0 0
IKBKB deficiency causes SCID R-HSA-5602636 7.406795e-02 1.130 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 8.756113e-02 1.058 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 8.756113e-02 1.058 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 8.756113e-02 1.058 0 0
IRS activation R-HSA-74713 8.756113e-02 1.058 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 8.756113e-02 1.058 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 8.756113e-02 1.058 0 0
Type I hemidesmosome assembly R-HSA-446107 8.330634e-02 1.079 0 0
RSK activation R-HSA-444257 8.330634e-02 1.079 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.527917e-02 1.123 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 6.675176e-02 1.176 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.675176e-02 1.176 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.675176e-02 1.176 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.675176e-02 1.176 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 9.262456e-02 1.033 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 9.262456e-02 1.033 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 9.262456e-02 1.033 0 0
VLDLR internalisation and degradation R-HSA-8866427 9.262456e-02 1.033 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 9.262456e-02 1.033 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 9.262456e-02 1.033 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 9.262456e-02 1.033 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 9.262456e-02 1.033 0 0
Regulation of BACH1 activity R-HSA-9708530 8.064019e-02 1.093 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 9.601642e-02 1.018 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.601642e-02 1.018 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 9.601642e-02 1.018 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 8.257855e-02 1.083 0 0
Deadenylation of mRNA R-HSA-429947 8.254236e-02 1.083 0 0
Sema4D in semaphorin signaling R-HSA-400685 9.493738e-02 1.023 0 0
Signaling by Erythropoietin R-HSA-9006335 8.132419e-02 1.090 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.633701e-02 1.178 0 0
RAF activation R-HSA-5673000 8.964739e-02 1.047 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 7.438839e-02 1.128 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.880547e-02 1.162 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 7.619659e-02 1.118 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.283869e-02 1.138 0 0
Translation initiation complex formation R-HSA-72649 8.408404e-02 1.075 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 8.004419e-02 1.097 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 8.653267e-02 1.063 0 0
Regulation of mitotic cell cycle R-HSA-453276 8.653267e-02 1.063 0 0
UCH proteinases R-HSA-5689603 8.210334e-02 1.086 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.257855e-02 1.083 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.527917e-02 1.123 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 7.198959e-02 1.143 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.653267e-02 1.063 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 6.633701e-02 1.178 0 0
Regulation of CDH1 Function R-HSA-9764561 6.598076e-02 1.181 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.132419e-02 1.090 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.964739e-02 1.047 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.015001e-02 1.096 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.132419e-02 1.090 0 0
Toll-like Receptor Cascades R-HSA-168898 7.067507e-02 1.151 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.003326e-02 1.155 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 8.257855e-02 1.083 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.988536e-02 1.156 0 0
L1CAM interactions R-HSA-373760 8.264278e-02 1.083 0 0
Signaling by SCF-KIT R-HSA-1433557 8.303958e-02 1.081 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.988536e-02 1.156 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.619659e-02 1.118 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 8.330634e-02 1.079 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 9.601642e-02 1.018 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.132419e-02 1.090 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 8.653267e-02 1.063 0 0
Gap junction assembly R-HSA-190861 8.964739e-02 1.047 0 0
Signaling by PTK6 R-HSA-8848021 6.956426e-02 1.158 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.956426e-02 1.158 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.318461e-02 1.031 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 8.330634e-02 1.079 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 7.527917e-02 1.123 0 0
FOXO-mediated transcription R-HSA-9614085 6.829719e-02 1.166 0 0
Regulation of beta-cell development R-HSA-186712 8.015001e-02 1.096 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 8.330634e-02 1.079 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 8.330634e-02 1.079 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.880547e-02 1.162 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 9.403667e-02 1.027 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.064019e-02 1.093 0 0
SARS-CoV Infections R-HSA-9679506 7.828835e-02 1.106 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.633701e-02 1.178 0 0
Modulation by Mtb of host immune system R-HSA-9637628 8.330634e-02 1.079 0 0
Nephrin family interactions R-HSA-373753 8.257855e-02 1.083 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.632969e-02 1.016 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 9.632969e-02 1.016 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.649570e-02 1.015 0 0
Influenza Infection R-HSA-168255 9.654517e-02 1.015 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.722247e-02 1.012 0 0
G-protein mediated events R-HSA-112040 9.928086e-02 1.003 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.013632e-01 0.994 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.013632e-01 0.994 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.013632e-01 0.994 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.019404e-01 0.992 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 1.021564e-01 0.991 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.046813e-01 0.980 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.046813e-01 0.980 0 0
Downstream signal transduction R-HSA-186763 1.046813e-01 0.980 0 0
Unwinding of DNA R-HSA-176974 1.056085e-01 0.976 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.056085e-01 0.976 0 0
MAPK1 (ERK2) activation R-HSA-112411 1.056085e-01 0.976 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 1.056085e-01 0.976 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.056085e-01 0.976 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.072455e-01 0.970 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.072455e-01 0.970 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.072455e-01 0.970 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.077796e-01 0.967 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.083324e-01 0.965 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.083324e-01 0.965 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.112640e-01 0.954 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.112640e-01 0.954 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.118282e-01 0.951 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.118282e-01 0.951 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.118282e-01 0.951 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.118282e-01 0.951 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.118282e-01 0.951 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.124381e-01 0.949 0 0
RNA Polymerase III Transcription R-HSA-74158 1.124381e-01 0.949 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.128383e-01 0.948 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.128383e-01 0.948 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.128383e-01 0.948 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 1.128383e-01 0.948 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 1.128383e-01 0.948 0 0
Specification of primordial germ cells R-HSA-9827857 1.128383e-01 0.948 0 0
Orc1 removal from chromatin R-HSA-68949 1.170288e-01 0.932 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.177392e-01 0.929 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 1.177392e-01 0.929 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 1.177392e-01 0.929 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.177392e-01 0.929 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.177392e-01 0.929 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 1.177392e-01 0.929 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 1.177392e-01 0.929 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.186617e-01 0.926 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.186617e-01 0.926 0 0
Signaling by TGFB family members R-HSA-9006936 1.191336e-01 0.924 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.198076e-01 0.922 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.198076e-01 0.922 0 0
Regulation of TP53 Expression R-HSA-6804754 1.198076e-01 0.922 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.198076e-01 0.922 0 0
C6 deamination of adenosine R-HSA-75102 1.198076e-01 0.922 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.198076e-01 0.922 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.198076e-01 0.922 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.198076e-01 0.922 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.198076e-01 0.922 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.198076e-01 0.922 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.198076e-01 0.922 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.198076e-01 0.922 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.198076e-01 0.922 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.198076e-01 0.922 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.236828e-01 0.908 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.245257e-01 0.905 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.256424e-01 0.901 0 0
Signaling by Hedgehog R-HSA-5358351 1.265301e-01 0.898 0 0
Rab regulation of trafficking R-HSA-9007101 1.265633e-01 0.898 0 0
Glucose metabolism R-HSA-70326 1.265633e-01 0.898 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.273452e-01 0.895 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.303013e-01 0.885 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.303013e-01 0.885 0 0
Regulation of CDH11 function R-HSA-9762292 1.303013e-01 0.885 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 1.303013e-01 0.885 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.303013e-01 0.885 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.310437e-01 0.883 0 0
PKA activation in glucagon signalling R-HSA-164378 1.310437e-01 0.883 0 0
PKA activation R-HSA-163615 1.310437e-01 0.883 0 0
Mismatch Repair R-HSA-5358508 1.310437e-01 0.883 0 0
Polo-like kinase mediated events R-HSA-156711 1.310437e-01 0.883 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 1.314404e-01 0.881 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.325443e-01 0.878 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.327787e-01 0.877 0 0
Regulation of KIT signaling R-HSA-1433559 1.327787e-01 0.877 0 0
Stimuli-sensing channels R-HSA-2672351 1.336803e-01 0.874 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.379346e-01 0.860 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.379346e-01 0.860 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.379346e-01 0.860 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 1.379346e-01 0.860 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.379346e-01 0.860 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.379346e-01 0.860 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.379346e-01 0.860 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.379346e-01 0.860 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.379346e-01 0.860 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 1.412235e-01 0.850 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.417671e-01 0.848 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.419138e-01 0.848 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.445244e-01 0.840 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.460446e-01 0.836 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.460446e-01 0.836 0 0
Gap junction trafficking and regulation R-HSA-157858 1.475590e-01 0.831 0 0
Reproduction R-HSA-1474165 1.488136e-01 0.827 0 0
TCR signaling R-HSA-202403 1.501311e-01 0.824 0 0
Signaling by LTK in cancer R-HSA-9842640 1.511605e-01 0.821 0 0
STAT5 Activation R-HSA-9645135 1.511605e-01 0.821 0 0
Erythropoietin activates STAT5 R-HSA-9027283 1.511605e-01 0.821 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.511605e-01 0.821 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 1.511605e-01 0.821 0 0
DNA Replication R-HSA-69306 1.533817e-01 0.814 0 0
DCC mediated attractive signaling R-HSA-418885 1.553381e-01 0.809 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.553381e-01 0.809 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.553381e-01 0.809 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.571199e-01 0.804 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.571199e-01 0.804 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.571199e-01 0.804 0 0
Signaling by APC mutants R-HSA-4839744 1.571199e-01 0.804 0 0
Sensory processing of sound R-HSA-9659379 1.576913e-01 0.802 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 1.579057e-01 0.802 0 0
Mitophagy R-HSA-5205647 1.614247e-01 0.792 0 0
Interleukin-6 family signaling R-HSA-6783589 1.627412e-01 0.789 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.630526e-01 0.788 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 1.650867e-01 0.782 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.568501e-01 0.590 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.568501e-01 0.590 0 0
Defective Mismatch Repair Associated With PMS2 R-HSA-5632987 2.568501e-01 0.590 0 0
Defective Mismatch Repair Associated With MLH1 R-HSA-5545483 2.568501e-01 0.590 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.568501e-01 0.590 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.568501e-01 0.590 0 0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) R-HSA-5619043 2.568501e-01 0.590 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.705485e-01 0.768 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.705485e-01 0.768 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 2.240422e-01 0.650 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.240422e-01 0.650 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.240422e-01 0.650 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.240422e-01 0.650 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 2.240422e-01 0.650 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.240422e-01 0.650 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 1.871565e-01 0.728 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.871565e-01 0.728 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.871565e-01 0.728 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.871565e-01 0.728 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.871565e-01 0.728 0 0
Netrin mediated repulsion signals R-HSA-418886 1.871565e-01 0.728 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.871565e-01 0.728 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.871565e-01 0.728 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.871565e-01 0.728 0 0
SOS-mediated signalling R-HSA-112412 1.871565e-01 0.728 0 0
Disinhibition of SNARE formation R-HSA-114516 1.871565e-01 0.728 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.785647e-01 0.555 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.785647e-01 0.555 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 2.785647e-01 0.555 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 2.785647e-01 0.555 0 0
Regulation by c-FLIP R-HSA-3371378 2.250707e-01 0.648 0 0
Dimerization of procaspase-8 R-HSA-69416 2.250707e-01 0.648 0 0
MET receptor recycling R-HSA-8875656 2.250707e-01 0.648 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.857707e-01 0.731 0 0
Activation of RAC1 R-HSA-428540 1.857707e-01 0.731 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.159441e-01 0.666 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.159441e-01 0.666 0 0
Calcineurin activates NFAT R-HSA-2025928 2.642840e-01 0.578 0 0
CASP8 activity is inhibited R-HSA-5218900 2.642840e-01 0.578 0 0
ALK mutants bind TKIs R-HSA-9700645 2.642840e-01 0.578 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.046313e-01 0.689 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.473258e-01 0.607 0 0
Signalling to RAS R-HSA-167044 1.930862e-01 0.714 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.042292e-01 0.517 0 0
2-LTR circle formation R-HSA-164843 3.042292e-01 0.517 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.042292e-01 0.517 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.713538e-01 0.766 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 2.158854e-01 0.666 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.796058e-01 0.553 0 0
cGMP effects R-HSA-418457 2.796058e-01 0.553 0 0
GAB1 signalosome R-HSA-180292 2.582797e-01 0.588 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.582797e-01 0.588 0 0
Trafficking of AMPA receptors R-HSA-399719 1.892556e-01 0.723 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.775431e-01 0.751 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.395420e-01 0.621 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 2.395420e-01 0.621 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 1.667523e-01 0.778 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 1.667523e-01 0.778 0 0
Erythropoietin activates RAS R-HSA-9027284 3.124852e-01 0.505 0 0
p38MAPK events R-HSA-171007 3.124852e-01 0.505 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 2.862619e-01 0.543 0 0
Interleukin receptor SHC signaling R-HSA-912526 2.639260e-01 0.579 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 2.444635e-01 0.612 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.272378e-01 0.644 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.852391e-01 0.732 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.666690e-01 0.574 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.889053e-01 0.539 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.665802e-01 0.778 0 0
Dual incision in TC-NER R-HSA-6782135 1.890739e-01 0.723 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.893943e-01 0.539 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 2.893943e-01 0.539 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.031896e-01 0.692 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.675538e-01 0.573 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 2.666956e-01 0.574 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.849898e-01 0.545 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 2.849898e-01 0.545 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.825882e-01 0.549 0 0
Meiotic synapsis R-HSA-1221632 3.001707e-01 0.523 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.001707e-01 0.523 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 2.286824e-01 0.641 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 2.286824e-01 0.641 0 0
Eukaryotic Translation Initiation R-HSA-72613 2.264605e-01 0.645 0 0
Cap-dependent Translation Initiation R-HSA-72737 2.264605e-01 0.645 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.536681e-01 0.596 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.536681e-01 0.596 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.964294e-01 0.707 0 0
Nuclear Receptor transcription pathway R-HSA-383280 3.006882e-01 0.522 0 0
HCMV Early Events R-HSA-9609690 2.038202e-01 0.691 0 0
PPARA activates gene expression R-HSA-1989781 2.801462e-01 0.553 0 0
Neutrophil degranulation R-HSA-6798695 2.482371e-01 0.605 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 2.380457e-01 0.623 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.851615e-01 0.732 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.019987e-01 0.695 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.109714e-01 0.676 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 1.713538e-01 0.766 0 0
NGF-stimulated transcription R-HSA-9031628 3.225448e-01 0.491 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.307423e-01 0.481 0 0
Signaling by FGFR R-HSA-190236 1.996863e-01 0.700 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 2.639260e-01 0.579 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.159441e-01 0.666 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.228750e-01 0.652 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.487910e-01 0.604 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 1.750398e-01 0.757 0 0
Extension of Telomeres R-HSA-180786 2.966359e-01 0.528 0 0
Insulin receptor signalling cascade R-HSA-74751 2.771936e-01 0.557 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 1.978952e-01 0.704 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.143477e-01 0.503 0 0
Growth hormone receptor signaling R-HSA-982772 2.639260e-01 0.579 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.906865e-01 0.720 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 2.642840e-01 0.578 0 0
Processing of SMDT1 R-HSA-8949664 2.473258e-01 0.607 0 0
PI3K/AKT activation R-HSA-198203 3.042292e-01 0.517 0 0
Regulation of Apoptosis R-HSA-169911 1.775431e-01 0.751 0 0
Nuclear RNA decay R-HSA-9930044 2.272378e-01 0.644 0 0
Meiotic recombination R-HSA-912446 1.736719e-01 0.760 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.906084e-01 0.720 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 1.871565e-01 0.728 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 2.666956e-01 0.574 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 2.839291e-01 0.547 0 0
Regulation of IFNG signaling R-HSA-877312 2.159441e-01 0.666 0 0
Signalling to ERKs R-HSA-187687 1.775431e-01 0.751 0 0
mTORC1-mediated signalling R-HSA-166208 2.395420e-01 0.621 0 0
E2F mediated regulation of DNA replication R-HSA-113510 2.862619e-01 0.543 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.444635e-01 0.612 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.166676e-01 0.664 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.653259e-01 0.576 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.906663e-01 0.720 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.133489e-01 0.504 0 0
Interleukin-1 signaling R-HSA-9020702 1.685758e-01 0.773 0 0
Signaling by NOTCH R-HSA-157118 2.098583e-01 0.678 0 0
HSF1 activation R-HSA-3371511 1.943567e-01 0.711 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 1.707248e-01 0.768 0 0
Degradation of DVL R-HSA-4641258 2.118180e-01 0.674 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.852391e-01 0.732 0 0
ESR-mediated signaling R-HSA-8939211 1.891522e-01 0.723 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.653259e-01 0.576 0 0
Neurexins and neuroligins R-HSA-6794361 1.875181e-01 0.727 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.815722e-01 0.550 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.782796e-01 0.749 0 0
NADE modulates death signalling R-HSA-205025 2.240422e-01 0.650 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.857707e-01 0.731 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.820181e-01 0.740 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 1.687257e-01 0.773 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.886188e-01 0.540 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.870576e-01 0.542 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.870576e-01 0.542 0 0
PCP/CE pathway R-HSA-4086400 2.154010e-01 0.667 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.743273e-01 0.562 0 0
Gap junction trafficking R-HSA-190828 2.487910e-01 0.604 0 0
Cellular response to hypoxia R-HSA-1234174 2.930646e-01 0.533 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.788084e-01 0.748 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.862619e-01 0.543 0 0
Signaling by FGFR in disease R-HSA-1226099 2.431739e-01 0.614 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.820181e-01 0.740 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.048776e-01 0.516 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 2.240422e-01 0.650 0 0
Signaling by LTK R-HSA-9842663 2.159441e-01 0.666 0 0
MAPK family signaling cascades R-HSA-5683057 2.851886e-01 0.545 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.547505e-01 0.594 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.038202e-01 0.691 0 0
Regulated Necrosis R-HSA-5218859 2.448629e-01 0.611 0 0
Cellular response to chemical stress R-HSA-9711123 2.279710e-01 0.642 0 0
DARPP-32 events R-HSA-180024 2.666690e-01 0.574 0 0
Plasma lipoprotein clearance R-HSA-8964043 2.484730e-01 0.605 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.484730e-01 0.605 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.212304e-01 0.655 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.212304e-01 0.655 0 0
Formation of paraxial mesoderm R-HSA-9793380 2.314380e-01 0.636 0 0
Interleukin-27 signaling R-HSA-9020956 3.042292e-01 0.517 0 0
Interleukin-7 signaling R-HSA-1266695 1.819256e-01 0.740 0 0
Interleukin-12 family signaling R-HSA-447115 1.903426e-01 0.720 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.796058e-01 0.553 0 0
Syndecan interactions R-HSA-3000170 2.639260e-01 0.579 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.653259e-01 0.576 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.985313e-01 0.702 0 0
SDK interactions R-HSA-373756 2.568501e-01 0.590 0 0
Inhibition of PKR R-HSA-169131 2.568501e-01 0.590 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.705485e-01 0.768 0 0
MTF1 activates gene expression R-HSA-5660489 2.240422e-01 0.650 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.240422e-01 0.650 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.240422e-01 0.650 0 0
Dopamine receptors R-HSA-390651 2.240422e-01 0.650 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 1.871565e-01 0.728 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.857707e-01 0.731 0 0
Signaling by AXIN mutants R-HSA-4839735 1.857707e-01 0.731 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 1.793471e-01 0.746 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.582797e-01 0.588 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 2.676685e-01 0.572 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 3.099574e-01 0.509 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.616119e-01 0.582 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.743273e-01 0.562 0 0
RSV-host interactions R-HSA-9833110 2.809861e-01 0.551 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.267431e-01 0.644 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.380800e-01 0.623 0 0
Other semaphorin interactions R-HSA-416700 3.124852e-01 0.505 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.272378e-01 0.644 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.042292e-01 0.517 0 0
Signaling by KIT in disease R-HSA-9669938 2.395420e-01 0.621 0 0
Signaling by ERBB4 R-HSA-1236394 2.431739e-01 0.614 0 0
Hemostasis R-HSA-109582 1.729533e-01 0.762 0 0
Regulated proteolysis of p75NTR R-HSA-193692 2.642840e-01 0.578 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.642840e-01 0.578 0 0
Signal regulatory protein family interactions R-HSA-391160 2.796058e-01 0.553 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.471832e-01 0.607 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.676685e-01 0.572 0 0
Ion channel transport R-HSA-983712 3.089385e-01 0.510 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.228750e-01 0.652 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.930862e-01 0.714 0 0
Interleukin-12 signaling R-HSA-9020591 1.907929e-01 0.719 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.159441e-01 0.666 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.159441e-01 0.666 0 0
Cellular response to mitochondrial stress R-HSA-9840373 2.642840e-01 0.578 0 0
Insulin processing R-HSA-264876 2.228750e-01 0.652 0 0
Inositol phosphate metabolism R-HSA-1483249 1.676765e-01 0.776 0 0
RMTs methylate histone arginines R-HSA-3214858 2.487910e-01 0.604 0 0
Negative regulation of FLT3 R-HSA-9706369 1.793471e-01 0.746 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 2.642840e-01 0.578 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.042292e-01 0.517 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.487910e-01 0.604 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.031896e-01 0.692 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.867325e-01 0.729 0 0
Glycogen synthesis R-HSA-3322077 3.147630e-01 0.502 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 3.308374e-01 0.480 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 3.316073e-01 0.479 0 0
Degradation of AXIN R-HSA-4641257 3.316073e-01 0.479 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 3.316073e-01 0.479 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 3.328150e-01 0.478 0 0
PKB-mediated events R-HSA-109703 3.328150e-01 0.478 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.328150e-01 0.478 0 0
PDE3B signalling R-HSA-165160 3.328150e-01 0.478 0 0
Formation of lateral plate mesoderm R-HSA-9758920 3.328150e-01 0.478 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.328150e-01 0.478 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 3.328150e-01 0.478 0 0
G0 and Early G1 R-HSA-1538133 3.360101e-01 0.474 0 0
HDACs deacetylate histones R-HSA-3214815 3.361235e-01 0.474 0 0
Myogenesis R-HSA-525793 3.401224e-01 0.468 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.401224e-01 0.468 0 0
Basigin interactions R-HSA-210991 3.435994e-01 0.464 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.435994e-01 0.464 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 3.435994e-01 0.464 0 0
Bicarbonate transporters R-HSA-425381 3.444004e-01 0.463 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.444004e-01 0.463 0 0
Suppression of apoptosis R-HSA-9635465 3.444004e-01 0.463 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.456823e-01 0.461 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.456823e-01 0.461 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.456823e-01 0.461 0 0
Adherens junctions interactions R-HSA-418990 3.473575e-01 0.459 0 0
TBC/RABGAPs R-HSA-8854214 3.474897e-01 0.459 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.474897e-01 0.459 0 0
Signaling by PDGF R-HSA-186797 3.481023e-01 0.458 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 3.481023e-01 0.458 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.509542e-01 0.455 0 0
Opioid Signalling R-HSA-111885 3.509542e-01 0.455 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 3.536318e-01 0.451 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.551737e-01 0.450 0 0
ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 3.593680e-01 0.444 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 3.593680e-01 0.444 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5660686 3.593680e-01 0.444 0 0
Defective GALE causes EDG R-HSA-5609977 3.593680e-01 0.444 0 0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) R-HSA-5619101 3.593680e-01 0.444 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 3.593680e-01 0.444 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 3.593680e-01 0.444 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 3.593680e-01 0.444 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.593680e-01 0.444 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.593680e-01 0.444 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 3.593680e-01 0.444 0 0
Defective HK1 causes hexokinase deficiency (HK deficiency) R-HSA-5619056 3.593680e-01 0.444 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 3.593680e-01 0.444 0 0
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 R-HSA-5083628 3.593680e-01 0.444 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 3.593680e-01 0.444 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 3.593680e-01 0.444 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.593680e-01 0.444 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 3.593680e-01 0.444 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 3.593680e-01 0.444 0 0
Transport of connexins along the secretory pathway R-HSA-190827 3.593680e-01 0.444 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.593680e-01 0.444 0 0
Oligomerization of connexins into connexons R-HSA-190704 3.593680e-01 0.444 0 0
Integrin signaling R-HSA-354192 3.597052e-01 0.444 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.597052e-01 0.444 0 0
PI3K Cascade R-HSA-109704 3.610445e-01 0.442 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 3.630319e-01 0.440 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.634737e-01 0.440 0 0
Potential therapeutics for SARS R-HSA-9679191 3.651834e-01 0.437 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.661024e-01 0.436 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.661024e-01 0.436 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.661024e-01 0.436 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.725958e-01 0.429 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 3.725958e-01 0.429 0 0
Assembly Of The HIV Virion R-HSA-175474 3.725958e-01 0.429 0 0
IRS-mediated signalling R-HSA-112399 3.728343e-01 0.428 0 0
COPII-mediated vesicle transport R-HSA-204005 3.756310e-01 0.425 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.773157e-01 0.423 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.789361e-01 0.421 0 0
Platelet activation, signaling and aggregation R-HSA-76002 3.792864e-01 0.421 0 0
HSF1-dependent transactivation R-HSA-3371571 3.805194e-01 0.420 0 0
IGF1R signaling cascade R-HSA-2428924 3.832461e-01 0.417 0 0
ERKs are inactivated R-HSA-202670 3.843561e-01 0.415 0 0
Integration of provirus R-HSA-162592 3.843561e-01 0.415 0 0
Chylomicron clearance R-HSA-8964026 3.858312e-01 0.414 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 3.858312e-01 0.414 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 3.858312e-01 0.414 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.858312e-01 0.414 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.858312e-01 0.414 0 0
HIV elongation arrest and recovery R-HSA-167287 3.921652e-01 0.407 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.921652e-01 0.407 0 0
Hedgehog 'on' state R-HSA-5632684 3.925560e-01 0.406 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.951520e-01 0.403 0 0
Generation of second messenger molecules R-HSA-202433 3.976629e-01 0.400 0 0
Attenuation phase R-HSA-3371568 3.976629e-01 0.400 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 3.976629e-01 0.400 0 0
Interleukin-2 family signaling R-HSA-451927 3.976629e-01 0.400 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.976629e-01 0.400 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 4.000764e-01 0.398 1 1
Downstream TCR signaling R-HSA-202424 4.004536e-01 0.397 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.009545e-01 0.397 0 0
FGFR2 alternative splicing R-HSA-6803529 4.015872e-01 0.396 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.015872e-01 0.396 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.015872e-01 0.396 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.048968e-01 0.393 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.086343e-01 0.389 0 0
Cell-cell junction organization R-HSA-421270 4.099090e-01 0.387 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.120092e-01 0.385 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 4.120092e-01 0.385 0 0
Glycogen storage diseases R-HSA-3229121 4.120092e-01 0.385 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 4.173104e-01 0.380 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.181948e-01 0.379 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.181948e-01 0.379 0 0
Platelet calcium homeostasis R-HSA-418360 4.181948e-01 0.379 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.205625e-01 0.376 0 0
MET activates RAS signaling R-HSA-8851805 4.237197e-01 0.373 0 0
Polymerase switching R-HSA-69091 4.237197e-01 0.373 0 0
Leading Strand Synthesis R-HSA-69109 4.237197e-01 0.373 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.237197e-01 0.373 0 0
Interleukin-35 Signalling R-HSA-8984722 4.237197e-01 0.373 0 0
Interleukin-15 signaling R-HSA-8983432 4.237197e-01 0.373 0 0
Adaptive Immune System R-HSA-1280218 4.257573e-01 0.371 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 4.285593e-01 0.368 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 4.302421e-01 0.366 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 4.369216e-01 0.360 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 4.369216e-01 0.360 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 4.369216e-01 0.360 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 4.369216e-01 0.360 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.418892e-01 0.355 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.440818e-01 0.353 0 0
DAP12 signaling R-HSA-2424491 4.440818e-01 0.353 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.440818e-01 0.353 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.440818e-01 0.353 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.446891e-01 0.352 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.446891e-01 0.352 0 0
Tie2 Signaling R-HSA-210993 4.446891e-01 0.352 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.446891e-01 0.352 0 0
Protein folding R-HSA-391251 4.461698e-01 0.350 0 0
Signaling by Insulin receptor R-HSA-74752 4.461698e-01 0.350 0 0
EPH-Ephrin signaling R-HSA-2682334 4.461698e-01 0.350 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.477486e-01 0.349 0 0
Regulation of cortical dendrite branching R-HSA-8985801 4.477486e-01 0.349 0 0
Essential pentosuria R-HSA-5662853 4.477486e-01 0.349 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 4.477486e-01 0.349 0 0
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 R-HSA-5083633 4.477486e-01 0.349 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 4.477486e-01 0.349 0 0
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 R-HSA-5083629 4.477486e-01 0.349 0 0
Signalling to ERK5 R-HSA-198765 4.477486e-01 0.349 0 0
DSCAM interactions R-HSA-376172 4.477486e-01 0.349 0 0
Diseases of cellular response to stress R-HSA-9675132 4.477486e-01 0.349 0 0
Diseases of Cellular Senescence R-HSA-9630747 4.477486e-01 0.349 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 4.477486e-01 0.349 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 4.477486e-01 0.349 0 0
Intraflagellar transport R-HSA-5620924 4.509223e-01 0.346 0 0
tRNA processing R-HSA-72306 4.538443e-01 0.343 0 0
Cellular response to starvation R-HSA-9711097 4.576489e-01 0.339 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 4.589544e-01 0.338 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 4.589544e-01 0.338 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 4.621774e-01 0.335 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.621774e-01 0.335 0 0
Formation of axial mesoderm R-HSA-9796292 4.621774e-01 0.335 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 4.621774e-01 0.335 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 4.621774e-01 0.335 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.650638e-01 0.332 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.655646e-01 0.332 0 0
Budding and maturation of HIV virion R-HSA-162588 4.697248e-01 0.328 0 0
Signaling by WNT R-HSA-195721 4.728898e-01 0.325 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 4.767893e-01 0.322 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.767893e-01 0.322 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.767893e-01 0.322 0 0
The NLRP3 inflammasome R-HSA-844456 4.767893e-01 0.322 0 0
Other interleukin signaling R-HSA-449836 4.767893e-01 0.322 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.774522e-01 0.321 0 0
Mitochondrial biogenesis R-HSA-1592230 4.798519e-01 0.319 0 0
Cytoprotection by HMOX1 R-HSA-9707564 4.825820e-01 0.316 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.825820e-01 0.316 0 0
rRNA processing R-HSA-72312 4.829024e-01 0.316 0 0
Platelet homeostasis R-HSA-418346 4.854746e-01 0.314 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 4.856089e-01 0.314 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.856089e-01 0.314 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 4.856089e-01 0.314 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 4.856089e-01 0.314 0 0
Interleukin-23 signaling R-HSA-9020933 4.856089e-01 0.314 0 0
Co-stimulation by ICOS R-HSA-9927354 4.856089e-01 0.314 0 0
TGFBR3 PTM regulation R-HSA-9839383 4.856089e-01 0.314 0 0
Response of Mtb to phagocytosis R-HSA-9637690 4.856342e-01 0.314 0 0
Signaling by WNT in cancer R-HSA-4791275 4.950308e-01 0.305 0 0
Prolactin receptor signaling R-HSA-1170546 4.994739e-01 0.301 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 4.994739e-01 0.301 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 4.994739e-01 0.301 0 0
Zinc transporters R-HSA-435354 4.994739e-01 0.301 0 0
HDL assembly R-HSA-8963896 4.994739e-01 0.301 0 0
Gene Silencing by RNA R-HSA-211000 4.996763e-01 0.301 0 0
MET promotes cell motility R-HSA-8875878 5.015804e-01 0.300 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.015804e-01 0.300 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.067510e-01 0.295 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 5.081488e-01 0.294 0 0
Gastrulation R-HSA-9758941 5.098493e-01 0.293 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.103788e-01 0.292 0 0
PI Metabolism R-HSA-1483255 5.103788e-01 0.292 0 0
RNA Polymerase I Transcription R-HSA-73864 5.109677e-01 0.292 0 0
Suppression of phagosomal maturation R-HSA-9637687 5.146338e-01 0.289 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.164709e-01 0.287 0 0
G-protein beta:gamma signalling R-HSA-397795 5.199152e-01 0.284 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 5.239408e-01 0.281 0 0
PLC-gamma1 signalling R-HSA-167021 5.239408e-01 0.281 0 0
Invadopodia formation R-HSA-8941237 5.239408e-01 0.281 0 0
Defective DPM1 causes DPM1-CDG R-HSA-4717374 5.239408e-01 0.281 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 5.239408e-01 0.281 0 0
Defective MAOA causes BRUNS R-HSA-5579012 5.239408e-01 0.281 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 5.239408e-01 0.281 0 0
Defective DPM3 causes DPM3-CDG R-HSA-4719360 5.239408e-01 0.281 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 5.239408e-01 0.281 0 0
Defective ABCC2 causes DJS R-HSA-5679001 5.239408e-01 0.281 0 0
Defective DPM2 causes DPM2-CDG R-HSA-4719377 5.239408e-01 0.281 0 0
MET activates STAT3 R-HSA-8875791 5.239408e-01 0.281 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 5.239408e-01 0.281 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 5.239408e-01 0.281 0 0
Intracellular oxygen transport R-HSA-8981607 5.239408e-01 0.281 0 0
Histamine receptors R-HSA-390650 5.239408e-01 0.281 0 0
FasL/ CD95L signaling R-HSA-75157 5.239408e-01 0.281 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.284193e-01 0.277 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.315838e-01 0.274 0 0
Lipophagy R-HSA-9613354 5.315838e-01 0.274 0 0
WNT mediated activation of DVL R-HSA-201688 5.315838e-01 0.274 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 5.315838e-01 0.274 0 0
mRNA Editing R-HSA-75072 5.315838e-01 0.274 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 5.315838e-01 0.274 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 5.315838e-01 0.274 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 5.315838e-01 0.274 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 5.315838e-01 0.274 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.336795e-01 0.273 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 5.354081e-01 0.271 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 5.354081e-01 0.271 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.383566e-01 0.269 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.384718e-01 0.269 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.386314e-01 0.269 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 5.386314e-01 0.269 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.415674e-01 0.266 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.415674e-01 0.266 0 0
Signaling by BMP R-HSA-201451 5.415674e-01 0.266 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.415674e-01 0.266 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 5.415674e-01 0.266 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.415674e-01 0.266 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 5.415674e-01 0.266 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.415674e-01 0.266 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.443024e-01 0.264 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.443024e-01 0.264 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.468780e-01 0.262 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 5.488626e-01 0.261 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 5.493205e-01 0.260 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.493205e-01 0.260 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.493205e-01 0.260 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.493205e-01 0.260 0 0
Signaling by RAS mutants R-HSA-6802949 5.493205e-01 0.260 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.580832e-01 0.253 0 0
Signal amplification R-HSA-392518 5.681257e-01 0.246 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.681257e-01 0.246 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 5.698272e-01 0.244 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.698272e-01 0.244 0 0
Phosphorylation of the APC/C R-HSA-176412 5.698272e-01 0.244 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.698272e-01 0.244 0 0
Prolonged ERK activation events R-HSA-169893 5.698272e-01 0.244 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.698272e-01 0.244 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.698272e-01 0.244 0 0
Transcription of the HIV genome R-HSA-167172 5.734185e-01 0.242 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.736756e-01 0.241 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.746680e-01 0.241 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.746680e-01 0.241 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 5.746680e-01 0.241 0 0
Receptor Mediated Mitophagy R-HSA-8934903 5.746680e-01 0.241 0 0
Regulation of the apoptosome activity R-HSA-9627069 5.746680e-01 0.241 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 5.746680e-01 0.241 0 0
Formation of apoptosome R-HSA-111458 5.746680e-01 0.241 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 5.746680e-01 0.241 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.826869e-01 0.235 0 0
Viral Infection Pathways R-HSA-9824446 5.865160e-01 0.232 0 0
HCMV Infection R-HSA-9609646 5.895393e-01 0.229 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 5.896247e-01 0.229 0 0
HCN channels R-HSA-1296061 5.896247e-01 0.229 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.896247e-01 0.229 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 5.896247e-01 0.229 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.896247e-01 0.229 0 0
Defective SLC7A9 causes cystinuria (CSNU) R-HSA-5660883 5.896247e-01 0.229 0 0
Defective SLC3A1 causes cystinuria (CSNU) R-HSA-5619113 5.896247e-01 0.229 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.896247e-01 0.229 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.896247e-01 0.229 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 5.896247e-01 0.229 0 0
Toxicity of tetanus toxin (tetX) R-HSA-5250982 5.896247e-01 0.229 0 0
G alpha (z) signalling events R-HSA-418597 5.898762e-01 0.229 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.901045e-01 0.229 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.903385e-01 0.229 0 0
HIV Transcription Initiation R-HSA-167161 5.903385e-01 0.229 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.903385e-01 0.229 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.913270e-01 0.228 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.913270e-01 0.228 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 5.913270e-01 0.228 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 5.931968e-01 0.227 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.933290e-01 0.227 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 5.965396e-01 0.224 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 5.965396e-01 0.224 0 0
LDL clearance R-HSA-8964038 5.965396e-01 0.224 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.979324e-01 0.223 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.979324e-01 0.223 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.979324e-01 0.223 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 6.026216e-01 0.220 0 0
tRNA modification in the mitochondrion R-HSA-6787450 6.026216e-01 0.220 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.026216e-01 0.220 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 6.072271e-01 0.217 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.077017e-01 0.216 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.077337e-01 0.216 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.112637e-01 0.214 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 6.147841e-01 0.211 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 6.147841e-01 0.211 0 0
vRNP Assembly R-HSA-192905 6.147841e-01 0.211 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 6.147841e-01 0.211 0 0
Interleukin-2 signaling R-HSA-9020558 6.147841e-01 0.211 0 0
Prostanoid ligand receptors R-HSA-391908 6.147841e-01 0.211 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.220755e-01 0.206 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.221294e-01 0.206 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.237762e-01 0.205 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.238059e-01 0.205 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.238059e-01 0.205 0 0
Immune System R-HSA-168256 6.258189e-01 0.204 1 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 6.265001e-01 0.203 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.304908e-01 0.200 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.316024e-01 0.200 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.337190e-01 0.198 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 6.337190e-01 0.198 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.356739e-01 0.197 0 0
Telomere Maintenance R-HSA-157579 6.358273e-01 0.197 0 0
IRE1alpha activates chaperones R-HSA-381070 6.364611e-01 0.196 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.373120e-01 0.196 0 0
Cargo concentration in the ER R-HSA-5694530 6.414276e-01 0.193 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 6.462493e-01 0.190 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 6.462493e-01 0.190 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 6.462493e-01 0.190 0 0
Activation of AKT2 R-HSA-165158 6.462493e-01 0.190 0 0
PTK6 Down-Regulation R-HSA-8849472 6.462493e-01 0.190 0 0
Reelin signalling pathway R-HSA-8866376 6.462493e-01 0.190 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 6.462493e-01 0.190 0 0
PTK6 Activates STAT3 R-HSA-8849474 6.462493e-01 0.190 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 6.462493e-01 0.190 0 0
Muscarinic acetylcholine receptors R-HSA-390648 6.462493e-01 0.190 0 0
Pyrophosphate hydrolysis R-HSA-71737 6.462493e-01 0.190 0 0
Co-inhibition by BTLA R-HSA-9927353 6.462493e-01 0.190 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 6.462493e-01 0.190 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 6.462493e-01 0.190 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 6.462493e-01 0.190 0 0
Post-translational protein phosphorylation R-HSA-8957275 6.494903e-01 0.187 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.498736e-01 0.187 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.498736e-01 0.187 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.498736e-01 0.187 0 0
Neurodegenerative Diseases R-HSA-8863678 6.498736e-01 0.187 0 0
XBP1(S) activates chaperone genes R-HSA-381038 6.519015e-01 0.186 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 6.519307e-01 0.186 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.519307e-01 0.186 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 6.519307e-01 0.186 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.519307e-01 0.186 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 6.519307e-01 0.186 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.535562e-01 0.185 0 0
HATs acetylate histones R-HSA-3214847 6.628820e-01 0.179 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.630795e-01 0.178 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.641580e-01 0.178 0 0
Signaling by Nuclear Receptors R-HSA-9006931 6.670614e-01 0.176 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.704048e-01 0.174 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.704048e-01 0.174 0 0
Somitogenesis R-HSA-9824272 6.704048e-01 0.174 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 6.747092e-01 0.171 0 0
TGFBR3 expression R-HSA-9839394 6.747092e-01 0.171 0 0
Long-term potentiation R-HSA-9620244 6.747092e-01 0.171 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.747092e-01 0.171 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.747092e-01 0.171 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.770437e-01 0.169 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.770437e-01 0.169 0 0
Signaling by ALK R-HSA-201556 6.770437e-01 0.169 0 0
RAS processing R-HSA-9648002 6.770437e-01 0.169 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.778818e-01 0.169 0 0
Transmission across Chemical Synapses R-HSA-112315 6.791382e-01 0.168 0 0
Amino acids regulate mTORC1 R-HSA-9639288 6.827931e-01 0.166 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 6.827931e-01 0.166 0 0
Smooth Muscle Contraction R-HSA-445355 6.827931e-01 0.166 0 0
RAF/MAP kinase cascade R-HSA-5673001 6.855027e-01 0.164 0 0
Protein ubiquitination R-HSA-8852135 6.858791e-01 0.164 1 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 6.861636e-01 0.164 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 6.861636e-01 0.164 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.861636e-01 0.164 0 0
Regulation of pyruvate metabolism R-HSA-9861718 6.888243e-01 0.162 0 0
ER-Phagosome pathway R-HSA-1236974 6.937065e-01 0.159 0 0
Phosphorylation of Emi1 R-HSA-176417 6.950634e-01 0.158 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.950634e-01 0.158 0 0
Signaling by MAPK mutants R-HSA-9652817 6.950634e-01 0.158 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.950634e-01 0.158 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.950634e-01 0.158 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.950634e-01 0.158 0 0
Synthesis of PS R-HSA-1483101 6.950634e-01 0.158 0 0
Synthesis of dolichyl-phosphate mannose R-HSA-162699 6.950634e-01 0.158 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 6.950634e-01 0.158 0 0
Release of Hh-Np from the secreting cell R-HSA-5362798 6.950634e-01 0.158 0 0
TRAIL signaling R-HSA-75158 6.950634e-01 0.158 0 0
HIV Transcription Elongation R-HSA-167169 6.965512e-01 0.157 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.965512e-01 0.157 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.965512e-01 0.157 0 0
Glycogen metabolism R-HSA-8982491 6.965512e-01 0.157 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 6.982946e-01 0.156 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.982946e-01 0.156 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.997003e-01 0.155 0 0
Platelet degranulation R-HSA-114608 7.049433e-01 0.152 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 7.067216e-01 0.151 0 0
Base Excision Repair R-HSA-73884 7.069537e-01 0.151 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.165614e-01 0.145 0 0
Formation of definitive endoderm R-HSA-9823730 7.165614e-01 0.145 0 0
Signal transduction by L1 R-HSA-445144 7.165614e-01 0.145 0 0
Signaling by NODAL R-HSA-1181150 7.165614e-01 0.145 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.165614e-01 0.145 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.165614e-01 0.145 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 7.175795e-01 0.144 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 7.175795e-01 0.144 0 0
Adenylate cyclase activating pathway R-HSA-170660 7.175795e-01 0.144 0 0
Frs2-mediated activation R-HSA-170968 7.175795e-01 0.144 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 7.175795e-01 0.144 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.175795e-01 0.144 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 7.175795e-01 0.144 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 7.226738e-01 0.141 0 0
GPER1 signaling R-HSA-9634597 7.236271e-01 0.140 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 7.265317e-01 0.139 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.265317e-01 0.139 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.265317e-01 0.139 0 0
ABC transporter disorders R-HSA-5619084 7.281797e-01 0.138 0 0
Ion homeostasis R-HSA-5578775 7.317339e-01 0.136 0 0
MAP2K and MAPK activation R-HSA-5674135 7.331480e-01 0.135 0 0
Intra-Golgi traffic R-HSA-6811438 7.331480e-01 0.135 0 0
Translation of Structural Proteins R-HSA-9683701 7.331480e-01 0.135 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 7.371441e-01 0.132 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 7.371441e-01 0.132 0 0
Autointegration results in viral DNA circles R-HSA-177539 7.371441e-01 0.132 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 7.371441e-01 0.132 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 7.371441e-01 0.132 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 7.371441e-01 0.132 0 0
MET Receptor Activation R-HSA-6806942 7.371441e-01 0.132 0 0
G2/M DNA replication checkpoint R-HSA-69478 7.371441e-01 0.132 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 7.371441e-01 0.132 0 0
Lactose synthesis R-HSA-5653890 7.371441e-01 0.132 0 0
Leukotriene receptors R-HSA-391906 7.371441e-01 0.132 0 0
HDL clearance R-HSA-8964011 7.371441e-01 0.132 0 0
VLDL assembly R-HSA-8866423 7.371441e-01 0.132 0 0
Neurofascin interactions R-HSA-447043 7.371441e-01 0.132 0 0
Ion transport by P-type ATPases R-HSA-936837 7.395381e-01 0.131 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 7.399949e-01 0.131 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 7.407216e-01 0.130 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.417064e-01 0.130 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.417064e-01 0.130 0 0
Inflammasomes R-HSA-622312 7.417064e-01 0.130 0 0
Eukaryotic Translation Elongation R-HSA-156842 7.445327e-01 0.128 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 7.463038e-01 0.127 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.463038e-01 0.127 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 7.463038e-01 0.127 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.470322e-01 0.127 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.556701e-01 0.122 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.570353e-01 0.121 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 7.615558e-01 0.118 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.619742e-01 0.118 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.632143e-01 0.117 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.632143e-01 0.117 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 7.632143e-01 0.117 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.632143e-01 0.117 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.632143e-01 0.117 0 0
ABC-family proteins mediated transport R-HSA-382556 7.632675e-01 0.117 0 0
Ribosome-associated quality control R-HSA-9948299 7.638212e-01 0.117 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.699087e-01 0.114 0 0
SLC transporter disorders R-HSA-5619102 7.723543e-01 0.112 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 7.724811e-01 0.112 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 7.724811e-01 0.112 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 7.724811e-01 0.112 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 7.724811e-01 0.112 0 0
DNA Damage Reversal R-HSA-73942 7.724811e-01 0.112 0 0
Signaling by Activin R-HSA-1502540 7.724811e-01 0.112 0 0
Protein methylation R-HSA-8876725 7.724811e-01 0.112 0 0
Peptide chain elongation R-HSA-156902 7.727881e-01 0.112 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 7.734198e-01 0.112 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 7.734198e-01 0.112 0 0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-964827 7.734198e-01 0.112 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 7.734198e-01 0.112 0 0
Recycling of eIF2:GDP R-HSA-72731 7.734198e-01 0.112 0 0
DAG1 core M1 glycosylations R-HSA-8932506 7.734198e-01 0.112 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 7.734198e-01 0.112 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 7.734198e-01 0.112 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 7.734198e-01 0.112 0 0
LDL remodeling R-HSA-8964041 7.734198e-01 0.112 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 7.734198e-01 0.112 0 0
VLDL clearance R-HSA-8964046 7.734198e-01 0.112 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 7.734198e-01 0.112 0 0
CHL1 interactions R-HSA-447041 7.734198e-01 0.112 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 7.734198e-01 0.112 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.792355e-01 0.108 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.801979e-01 0.108 0 0
Proteasome assembly R-HSA-9907900 7.819733e-01 0.107 0 0
DAP12 interactions R-HSA-2172127 7.819733e-01 0.107 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.819733e-01 0.107 0 0
Parasite infection R-HSA-9664407 7.820441e-01 0.107 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.820441e-01 0.107 0 0
Leishmania phagocytosis R-HSA-9664417 7.820441e-01 0.107 0 0
Chromosome Maintenance R-HSA-73886 7.823715e-01 0.107 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.840948e-01 0.106 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.840948e-01 0.106 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.840948e-01 0.106 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.840948e-01 0.106 0 0
Cellular hexose transport R-HSA-189200 7.840948e-01 0.106 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.840948e-01 0.106 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 7.849539e-01 0.105 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.850425e-01 0.105 0 0
Eukaryotic Translation Termination R-HSA-72764 7.894624e-01 0.103 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.919952e-01 0.101 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 7.962671e-01 0.099 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 7.962671e-01 0.099 0 0
Differentiation of T cells R-HSA-9945266 7.962671e-01 0.099 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 7.962671e-01 0.099 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 7.962671e-01 0.099 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 7.966558e-01 0.099 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 7.985757e-01 0.098 0 0
Muscle contraction R-HSA-397014 7.993869e-01 0.097 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 8.034273e-01 0.095 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 8.034273e-01 0.095 0 0
Interleukin-20 family signaling R-HSA-8854691 8.034273e-01 0.095 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.044846e-01 0.094 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 8.046911e-01 0.094 0 0
DAG1 core M2 glycosylations R-HSA-8932504 8.046911e-01 0.094 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 8.046911e-01 0.094 0 0
Formation of annular gap junctions R-HSA-196025 8.046911e-01 0.094 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 8.046911e-01 0.094 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 8.046911e-01 0.094 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 8.046911e-01 0.094 0 0
Fructose biosynthesis R-HSA-5652227 8.046911e-01 0.094 0 0
Adrenoceptors R-HSA-390696 8.046911e-01 0.094 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 8.046911e-01 0.094 0 0
phospho-PLA2 pathway R-HSA-111995 8.046911e-01 0.094 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 8.046911e-01 0.094 0 0
Interleukin-9 signaling R-HSA-8985947 8.046911e-01 0.094 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 8.046911e-01 0.094 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 8.046911e-01 0.094 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.053767e-01 0.094 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.079841e-01 0.093 0 0
Signaling by TGFBR3 R-HSA-9839373 8.105639e-01 0.091 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 8.110593e-01 0.091 0 0
NCAM signaling for neurite out-growth R-HSA-375165 8.134151e-01 0.090 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.139841e-01 0.089 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.139841e-01 0.089 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.178232e-01 0.087 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.178232e-01 0.087 0 0
Glycine degradation R-HSA-6783984 8.178232e-01 0.087 0 0
Galactose catabolism R-HSA-70370 8.178232e-01 0.087 0 0
Response to metal ions R-HSA-5660526 8.178232e-01 0.087 0 0
Thromboxane signalling through TP receptor R-HSA-428930 8.212822e-01 0.086 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 8.212822e-01 0.086 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.237153e-01 0.084 0 0
Cardiogenesis R-HSA-9733709 8.292227e-01 0.081 0 0
ARMS-mediated activation R-HSA-170984 8.316480e-01 0.080 0 0
Gap junction degradation R-HSA-190873 8.316480e-01 0.080 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 8.316480e-01 0.080 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 8.316480e-01 0.080 0 0
Enzymatic degradation of Dopamine by monoamine oxidase R-HSA-379398 8.316480e-01 0.080 0 0
Interleukin-21 signaling R-HSA-9020958 8.316480e-01 0.080 0 0
p75NTR regulates axonogenesis R-HSA-193697 8.316480e-01 0.080 0 0
Regulation of signaling by NODAL R-HSA-1433617 8.316480e-01 0.080 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 8.316480e-01 0.080 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 8.316480e-01 0.080 0 0
Interleukin-1 processing R-HSA-448706 8.316480e-01 0.080 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 8.316480e-01 0.080 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 8.316480e-01 0.080 0 0
Developmental Biology R-HSA-1266738 8.347927e-01 0.078 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.373118e-01 0.077 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.373118e-01 0.077 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.373118e-01 0.077 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.373118e-01 0.077 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.373118e-01 0.077 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.377345e-01 0.077 0 0
Tight junction interactions R-HSA-420029 8.377345e-01 0.077 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.433810e-01 0.074 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 8.434012e-01 0.074 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.458235e-01 0.073 0 0
Selenocysteine synthesis R-HSA-2408557 8.458235e-01 0.073 0 0
Ca2+ pathway R-HSA-4086398 8.470665e-01 0.072 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.484511e-01 0.071 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.508563e-01 0.070 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 8.548857e-01 0.068 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 8.548857e-01 0.068 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 8.548857e-01 0.068 0 0
Metabolism of serotonin R-HSA-380612 8.548857e-01 0.068 0 0
DNA replication initiation R-HSA-68952 8.548857e-01 0.068 0 0
Formation of intermediate mesoderm R-HSA-9761174 8.548857e-01 0.068 0 0
Arachidonate production from DAG R-HSA-426048 8.548857e-01 0.068 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 8.548857e-01 0.068 0 0
Enzymatic degradation of dopamine by COMT R-HSA-379397 8.548857e-01 0.068 0 0
Maturation of spike protein R-HSA-9683686 8.548857e-01 0.068 0 0
Nephron development R-HSA-9831926 8.548928e-01 0.068 0 0
Apoptotic factor-mediated response R-HSA-111471 8.548928e-01 0.068 0 0
Co-inhibition by PD-1 R-HSA-389948 8.566821e-01 0.067 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 8.569727e-01 0.067 0 0
Interferon alpha/beta signaling R-HSA-909733 8.586315e-01 0.066 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.624711e-01 0.064 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.667421e-01 0.062 0 0
Peroxisomal protein import R-HSA-9033241 8.668245e-01 0.062 0 0
Specification of the neural plate border R-HSA-9834899 8.707214e-01 0.060 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.707214e-01 0.060 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.707214e-01 0.060 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.707214e-01 0.060 0 0
Maturation of nucleoprotein R-HSA-9694631 8.707214e-01 0.060 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 8.707214e-01 0.060 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 8.749170e-01 0.058 0 0
DAG1 core M3 glycosylations R-HSA-8932505 8.749170e-01 0.058 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 8.749170e-01 0.058 0 0
FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 8.749170e-01 0.058 0 0
Chylomicron assembly R-HSA-8963888 8.749170e-01 0.058 0 0
Synthesis of PI R-HSA-1483226 8.749170e-01 0.058 0 0
Transport of RCbl within the body R-HSA-9758890 8.749170e-01 0.058 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 8.749170e-01 0.058 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 8.749170e-01 0.058 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.788896e-01 0.056 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.788896e-01 0.056 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 8.788896e-01 0.056 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.794544e-01 0.056 0 0
Telomere Extension By Telomerase R-HSA-171319 8.794544e-01 0.056 0 0
Insulin receptor recycling R-HSA-77387 8.794544e-01 0.056 0 0
GPVI-mediated activation cascade R-HSA-114604 8.801024e-01 0.055 0 0
G1/S-Specific Transcription R-HSA-69205 8.801024e-01 0.055 0 0
Triglyceride catabolism R-HSA-163560 8.801024e-01 0.055 0 0
Translation of Structural Proteins R-HSA-9694635 8.819686e-01 0.055 0 0
Regulation of insulin secretion R-HSA-422356 8.824032e-01 0.054 0 0
Amine ligand-binding receptors R-HSA-375280 8.834269e-01 0.054 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 8.849463e-01 0.053 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 8.849463e-01 0.053 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.849463e-01 0.053 0 0
Pregnenolone biosynthesis R-HSA-196108 8.849463e-01 0.053 0 0
Protein hydroxylation R-HSA-9629569 8.849463e-01 0.053 0 0
Neuronal System R-HSA-112316 8.869936e-01 0.052 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.888842e-01 0.051 0 0
mRNA Capping R-HSA-72086 8.910761e-01 0.050 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.921842e-01 0.050 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.921842e-01 0.050 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.921842e-01 0.050 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 8.921842e-01 0.050 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 8.921842e-01 0.050 0 0
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB R-HSA-141333 8.921842e-01 0.050 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 8.921842e-01 0.050 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 8.921842e-01 0.050 0 0
Parasitic Infection Pathways R-HSA-9824443 8.942609e-01 0.049 0 0
Leishmania infection R-HSA-9658195 8.942609e-01 0.049 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 8.977086e-01 0.047 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 8.977086e-01 0.047 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.977086e-01 0.047 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.002023e-01 0.046 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.002023e-01 0.046 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.016828e-01 0.045 0 0
HCMV Late Events R-HSA-9610379 9.035522e-01 0.044 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 9.070686e-01 0.042 0 0
GRB2 events in EGFR signaling R-HSA-179812 9.070686e-01 0.042 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 9.070686e-01 0.042 0 0
Scavenging by Class F Receptors R-HSA-3000484 9.070686e-01 0.042 0 0
Repression of WNT target genes R-HSA-4641265 9.070686e-01 0.042 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 9.070686e-01 0.042 0 0
Proline catabolism R-HSA-70688 9.070686e-01 0.042 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 9.070686e-01 0.042 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 9.070686e-01 0.042 0 0
Synthesis of GDP-mannose R-HSA-446205 9.070686e-01 0.042 0 0
Estrogen biosynthesis R-HSA-193144 9.070686e-01 0.042 0 0
OAS antiviral response R-HSA-8983711 9.070686e-01 0.042 0 0
Diseases of programmed cell death R-HSA-9645723 9.087584e-01 0.042 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.090900e-01 0.041 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.090900e-01 0.041 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.091409e-01 0.041 0 0
Attachment and Entry R-HSA-9694614 9.091409e-01 0.041 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 9.097062e-01 0.041 0 0
Integration of energy metabolism R-HSA-163685 9.097971e-01 0.041 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.113475e-01 0.040 0 0
Viral mRNA Translation R-HSA-192823 9.132078e-01 0.039 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 9.172668e-01 0.038 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.172668e-01 0.038 0 0
Diseases of Immune System R-HSA-5260271 9.172668e-01 0.038 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 9.193672e-01 0.037 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.193672e-01 0.037 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.193672e-01 0.037 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 9.193672e-01 0.037 0 0
OGDH complex synthesizes succinyl-CoA from 2-OG R-HSA-9853506 9.198989e-01 0.036 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 9.198989e-01 0.036 0 0
FGFR2c ligand binding and activation R-HSA-190375 9.198989e-01 0.036 0 0
FGFR1c ligand binding and activation R-HSA-190373 9.198989e-01 0.036 0 0
FGFR4 ligand binding and activation R-HSA-190322 9.198989e-01 0.036 0 0
Signaling by activated point mutants of FGFR3 R-HSA-1839130 9.198989e-01 0.036 0 0
FGFR3 mutant receptor activation R-HSA-2033514 9.198989e-01 0.036 0 0
Maturation of nucleoprotein R-HSA-9683610 9.198989e-01 0.036 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.201408e-01 0.036 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.240501e-01 0.034 0 0
Iron uptake and transport R-HSA-917937 9.240501e-01 0.034 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.247791e-01 0.034 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.247791e-01 0.034 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.251902e-01 0.034 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.272236e-01 0.033 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.281297e-01 0.032 0 0
FGFR3c ligand binding and activation R-HSA-190372 9.309584e-01 0.031 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 9.309584e-01 0.031 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 9.309584e-01 0.031 0 0
N-glycan trimming and elongation in the cis-Golgi R-HSA-964739 9.309584e-01 0.031 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 9.309584e-01 0.031 0 0
Physiological factors R-HSA-5578768 9.309584e-01 0.031 0 0
P2Y receptors R-HSA-417957 9.309584e-01 0.031 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 9.309584e-01 0.031 0 0
Malate-aspartate shuttle R-HSA-9856872 9.309584e-01 0.031 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.353779e-01 0.029 0 0
Heme degradation R-HSA-189483 9.353779e-01 0.029 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.366529e-01 0.028 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.366529e-01 0.028 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.366529e-01 0.028 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.366529e-01 0.028 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.366529e-01 0.028 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 9.404915e-01 0.027 0 0
G beta:gamma signalling through BTK R-HSA-8964315 9.404915e-01 0.027 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 9.404915e-01 0.027 0 0
Protein lipoylation R-HSA-9857492 9.404915e-01 0.027 0 0
Telomere C-strand synthesis initiation R-HSA-174430 9.404915e-01 0.027 0 0
FGFR3 ligand binding and activation R-HSA-190239 9.404915e-01 0.027 0 0
SHC1 events in EGFR signaling R-HSA-180336 9.404915e-01 0.027 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 9.404915e-01 0.027 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 9.404915e-01 0.027 0 0
Formation of the anterior neural plate R-HSA-9823739 9.404915e-01 0.027 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.409570e-01 0.026 0 0
Aquaporin-mediated transport R-HSA-445717 9.418743e-01 0.026 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.419457e-01 0.026 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.419457e-01 0.026 0 0
eNOS activation R-HSA-203615 9.419457e-01 0.026 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.419457e-01 0.026 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.426055e-01 0.026 0 0
Mitochondrial protein degradation R-HSA-9837999 9.436507e-01 0.025 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.439164e-01 0.025 0 0
Pyruvate metabolism R-HSA-70268 9.456193e-01 0.024 0 0
Neddylation R-HSA-8951664 9.460462e-01 0.024 0 0
Nucleotide biosynthesis R-HSA-8956320 9.471311e-01 0.024 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.478895e-01 0.023 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.478895e-01 0.023 0 0
Innate Immune System R-HSA-168249 9.485991e-01 0.023 1 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.487088e-01 0.023 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.487088e-01 0.023 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 9.487088e-01 0.023 0 0
Killing mechanisms R-HSA-9664420 9.487088e-01 0.023 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 9.487088e-01 0.023 0 0
Activation of SMO R-HSA-5635838 9.487088e-01 0.023 0 0
Attachment and Entry R-HSA-9678110 9.487088e-01 0.023 0 0
Atorvastatin ADME R-HSA-9754706 9.487088e-01 0.023 0 0
Virus Assembly and Release R-HSA-168268 9.487088e-01 0.023 0 0
MET activates PTK2 signaling R-HSA-8874081 9.503823e-01 0.022 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.503823e-01 0.022 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.503823e-01 0.022 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 9.512481e-01 0.022 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.532624e-01 0.021 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 9.557918e-01 0.020 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.557918e-01 0.020 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.557918e-01 0.020 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.557918e-01 0.020 0 0
Phase 2 - plateau phase R-HSA-5576893 9.557918e-01 0.020 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 9.557918e-01 0.020 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.557918e-01 0.020 0 0
Heme assimilation R-HSA-9927020 9.557918e-01 0.020 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.557918e-01 0.020 0 0
Formation of xylulose-5-phosphate R-HSA-5661270 9.557918e-01 0.020 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.561324e-01 0.019 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.561324e-01 0.019 0 0
Packaging Of Telomere Ends R-HSA-171306 9.561324e-01 0.019 0 0
Cristae formation R-HSA-8949613 9.561324e-01 0.019 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.581138e-01 0.019 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.582759e-01 0.019 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.582759e-01 0.019 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.612411e-01 0.017 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.618970e-01 0.017 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.618970e-01 0.017 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 9.618970e-01 0.017 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.618970e-01 0.017 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.624092e-01 0.017 0 0
Elastic fibre formation R-HSA-1566948 9.624896e-01 0.017 0 0
DNA methylation R-HSA-5334118 9.657758e-01 0.015 0 0
Metal ion SLC transporters R-HSA-425410 9.659338e-01 0.015 0 0
Pentose phosphate pathway R-HSA-71336 9.664324e-01 0.015 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.668867e-01 0.015 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.671594e-01 0.015 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 9.671594e-01 0.015 0 0
Activated point mutants of FGFR2 R-HSA-2033519 9.671594e-01 0.015 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.671594e-01 0.015 0 0
Synaptic adhesion-like molecules R-HSA-8849932 9.671594e-01 0.015 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 9.671594e-01 0.015 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.681729e-01 0.014 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.697975e-01 0.013 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.699138e-01 0.013 0 0
Triglyceride metabolism R-HSA-8979227 9.699138e-01 0.013 0 0
Integrin cell surface interactions R-HSA-216083 9.706126e-01 0.013 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.716953e-01 0.012 0 0
Pyrimidine biosynthesis R-HSA-500753 9.716953e-01 0.012 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.716953e-01 0.012 0 0
Amine Oxidase reactions R-HSA-140179 9.716953e-01 0.012 0 0
Azathioprine ADME R-HSA-9748787 9.722655e-01 0.012 0 0
tRNA Aminoacylation R-HSA-379724 9.726798e-01 0.012 0 0
Metabolism of polyamines R-HSA-351202 9.726798e-01 0.012 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.731735e-01 0.012 0 0
Maturation of spike protein R-HSA-9694548 9.731735e-01 0.012 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.733615e-01 0.012 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.733615e-01 0.012 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 9.756049e-01 0.011 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 9.756049e-01 0.011 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.756049e-01 0.011 0 0
Creatine metabolism R-HSA-71288 9.756049e-01 0.011 0 0
Synthesis of Ketone Bodies R-HSA-77111 9.756049e-01 0.011 0 0
DAG1 glycosylations R-HSA-8931838 9.765174e-01 0.010 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.765174e-01 0.010 0 0
Mitochondrial protein import R-HSA-1268020 9.775167e-01 0.010 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 9.786164e-01 0.009 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.786164e-01 0.009 0 0
Depyrimidination R-HSA-73928 9.786164e-01 0.009 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.789747e-01 0.009 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.789747e-01 0.009 0 0
FGFR2 ligand binding and activation R-HSA-190241 9.789747e-01 0.009 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.789747e-01 0.009 0 0
Abacavir metabolism R-HSA-2161541 9.789747e-01 0.009 0 0
Defective B3GALTL causes PpS R-HSA-5083635 9.793100e-01 0.009 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 9.793100e-01 0.009 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.801590e-01 0.009 0 0
Protein localization R-HSA-9609507 9.816554e-01 0.008 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.817794e-01 0.008 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.818791e-01 0.008 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.818791e-01 0.008 0 0
Serine metabolism R-HSA-977347 9.818791e-01 0.008 0 0
Glutathione synthesis and recycling R-HSA-174403 9.818791e-01 0.008 0 0
Paracetamol ADME R-HSA-9753281 9.836030e-01 0.007 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.839615e-01 0.007 0 0
Fructose metabolism R-HSA-5652084 9.843825e-01 0.007 0 0
Ethanol oxidation R-HSA-71384 9.843825e-01 0.007 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.843825e-01 0.007 0 0
Selenoamino acid metabolism R-HSA-2408522 9.845207e-01 0.007 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.848501e-01 0.007 0 0
Nucleosome assembly R-HSA-774815 9.848501e-01 0.007 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.852661e-01 0.006 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.860246e-01 0.006 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.860246e-01 0.006 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.863355e-01 0.006 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 9.865402e-01 0.006 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.865402e-01 0.006 0 0
Biosynthesis of maresins R-HSA-9018682 9.865402e-01 0.006 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.865402e-01 0.006 0 0
Ketone body metabolism R-HSA-74182 9.865402e-01 0.006 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.865402e-01 0.006 0 0
Formation of the ureteric bud R-HSA-9830674 9.865402e-01 0.006 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.875895e-01 0.005 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.875895e-01 0.005 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.879071e-01 0.005 0 0
CYP2E1 reactions R-HSA-211999 9.883999e-01 0.005 0 0
Complex III assembly R-HSA-9865881 9.883999e-01 0.005 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.883999e-01 0.005 0 0
O-glycosylation of TSR domain-containing proteins R-HSA-5173214 9.890899e-01 0.005 0 0
Cleavage of the damaged purine R-HSA-110331 9.890899e-01 0.005 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.890899e-01 0.005 0 0
NCAM1 interactions R-HSA-419037 9.890899e-01 0.005 0 0
Collagen chain trimerization R-HSA-8948216 9.890899e-01 0.005 0 0
Metabolism of folate and pterines R-HSA-196757 9.890899e-01 0.005 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.893196e-01 0.005 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.893461e-01 0.005 0 0
Alpha-oxidation of phytanate R-HSA-389599 9.900027e-01 0.004 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.900027e-01 0.004 0 0
Formation of the nephric duct R-HSA-9830364 9.900027e-01 0.004 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.900027e-01 0.004 0 0
Laminin interactions R-HSA-3000157 9.900027e-01 0.004 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.904127e-01 0.004 0 0
Depurination R-HSA-73927 9.904127e-01 0.004 0 0
Purine salvage R-HSA-74217 9.904127e-01 0.004 0 0
RAB geranylgeranylation R-HSA-8873719 9.904478e-01 0.004 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.905040e-01 0.004 0 0
Neurotransmitter release cycle R-HSA-112310 9.908952e-01 0.004 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.909192e-01 0.004 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.913015e-01 0.004 0 0
Urea cycle R-HSA-70635 9.913841e-01 0.004 0 0
Abacavir ADME R-HSA-2161522 9.913841e-01 0.004 0 0
Sphingolipid catabolism R-HSA-9845614 9.913841e-01 0.004 0 0
Linoleic acid (LA) metabolism R-HSA-2046105 9.913841e-01 0.004 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.913841e-01 0.004 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.913841e-01 0.004 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.915784e-01 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.920315e-01 0.003 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.925748e-01 0.003 0 0
Triglyceride biosynthesis R-HSA-75109 9.925748e-01 0.003 0 0
Synthesis of PE R-HSA-1483213 9.925748e-01 0.003 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.925748e-01 0.003 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.925748e-01 0.003 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.926051e-01 0.003 0 0
Pyrimidine salvage R-HSA-73614 9.936009e-01 0.003 0 0
Pyroptosis R-HSA-5620971 9.936009e-01 0.003 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.938584e-01 0.003 0 0
Post-translational protein modification R-HSA-597592 9.940273e-01 0.003 1 0
Collagen formation R-HSA-1474290 9.943346e-01 0.002 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.944853e-01 0.002 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.947610e-01 0.002 0 0
Activation of GABAB receptors R-HSA-991365 9.950037e-01 0.002 0 0
GABA B receptor activation R-HSA-977444 9.950037e-01 0.002 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.950037e-01 0.002 0 0
Neurotransmitter clearance R-HSA-112311 9.952475e-01 0.002 0 0
G alpha (s) signalling events R-HSA-418555 9.952776e-01 0.002 0 0
Kidney development R-HSA-9830369 9.956121e-01 0.002 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.956187e-01 0.002 0 0
Synthesis of glycosylphosphatidylinositol (GPI) R-HSA-162710 9.959044e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.960809e-01 0.002 0 0
Surfactant metabolism R-HSA-5683826 9.961592e-01 0.002 0 0
HS-GAG degradation R-HSA-2024096 9.964705e-01 0.002 0 0
Amyloid fiber formation R-HSA-977225 9.968428e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.968775e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.968805e-01 0.001 0 0
Recycling of bile acids and salts R-HSA-159418 9.969584e-01 0.001 0 0
Infectious disease R-HSA-5663205 9.970460e-01 0.001 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.970510e-01 0.001 0 0
Peptide hormone metabolism R-HSA-2980736 9.971323e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.972145e-01 0.001 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.977413e-01 0.001 0 0
Hyaluronan metabolism R-HSA-2142845 9.977413e-01 0.001 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.977413e-01 0.001 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.980274e-01 0.001 0 0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 9.980536e-01 0.001 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.982431e-01 0.001 0 0
Translation R-HSA-72766 9.982532e-01 0.001 0 0
HS-GAG biosynthesis R-HSA-2022928 9.983227e-01 0.001 0 0
Cardiac conduction R-HSA-5576891 9.983762e-01 0.001 0 0
The phototransduction cascade R-HSA-2514856 9.984838e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.985118e-01 0.001 0 0
Interferon gamma signaling R-HSA-877300 9.985237e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.985324e-01 0.001 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.985546e-01 0.001 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.986690e-01 0.001 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.987545e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.987613e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.989343e-01 0.000 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 9.990752e-01 0.000 0 0
Tryptophan catabolism R-HSA-71240 9.990752e-01 0.000 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.990752e-01 0.000 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.992031e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.992680e-01 0.000 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.993133e-01 0.000 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.993133e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.993291e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.993543e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.993543e-01 0.000 0 0
Defective pyroptosis R-HSA-9710421 9.994902e-01 0.000 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.995175e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.995489e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.995489e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.995489e-01 0.000 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.995607e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.996061e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.996061e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.996061e-01 0.000 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.996215e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.996985e-01 0.000 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.997190e-01 0.000 0 0
Synthesis of PC R-HSA-1483191 9.997190e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.997341e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.997381e-01 0.000 0 0
Gluconeogenesis R-HSA-70263 9.997579e-01 0.000 0 0
Developmental Cell Lineages R-HSA-9734767 9.997600e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.997660e-01 0.000 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.997914e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998189e-01 0.000 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.998202e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.998262e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.998451e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.998451e-01 0.000 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.998451e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.998879e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.998949e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.998996e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999008e-01 0.000 0 0
Glucuronidation R-HSA-156588 9.999009e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999165e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.999180e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999237e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999259e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.999265e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.999356e-01 0.000 0 0
Dectin-2 family R-HSA-5621480 9.999366e-01 0.000 0 0
Synthesis of PA R-HSA-1483166 9.999366e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.999530e-01 0.000 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.999595e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.999741e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999770e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999841e-01 0.000 0 0
Disease R-HSA-1643685 9.999851e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.999857e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999866e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.999877e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999904e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.999921e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999931e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.999932e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999932e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999947e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999960e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999968e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999968e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.999972e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999973e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999976e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999979e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999982e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999983e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999985e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999986e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999988e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999989e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999992e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999995e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999996e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999996e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999996e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999997e-01 0.000 1 0
Signaling by GPCR R-HSA-372790 9.999997e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999998e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999998e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999999e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999999e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 1.000000e+00 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Nucleotide catabolism R-HSA-8956319 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Gene expression (Transcription) R-HSA-74160 1.587619e-14 13.799 0 0
RNA Polymerase II Transcription R-HSA-73857 4.897527e-12 11.310 0 0
Generic Transcription Pathway R-HSA-212436 7.583723e-11 10.120 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.251591e-09 8.034 0 0
Regulation of TP53 Activity R-HSA-5633007 7.972801e-09 8.098 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.048351e-08 7.979 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 4.878280e-07 6.312 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.919352e-07 6.308 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 6.680427e-07 6.175 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.407037e-06 5.852 0 0
Cellular response to heat stress R-HSA-3371556 2.423524e-06 5.616 0 0
Cellular Senescence R-HSA-2559583 2.580157e-06 5.588 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.787160e-06 5.320 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.656595e-06 5.332 1 0
TGFBR3 expression R-HSA-9839394 5.587021e-06 5.253 0 0
Estrogen-dependent gene expression R-HSA-9018519 5.490791e-06 5.260 0 0
Gastrulation R-HSA-9758941 6.445360e-06 5.191 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.017567e-05 4.992 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.017567e-05 4.992 0 0
Signal Transduction R-HSA-162582 1.034143e-05 4.985 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.234838e-05 4.908 0 0
Formation of definitive endoderm R-HSA-9823730 1.415811e-05 4.849 0 0
Cell Cycle R-HSA-1640170 1.438371e-05 4.842 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.374618e-05 4.862 0 0
Chromatin organization R-HSA-4839726 1.378589e-05 4.861 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.704517e-05 4.768 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 2.151270e-05 4.667 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.271134e-05 4.644 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.854437e-05 4.544 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.747224e-05 4.561 1 1
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.819545e-05 4.418 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.819545e-05 4.418 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.896661e-05 4.409 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.864026e-05 4.413 0 0
Notch-HLH transcription pathway R-HSA-350054 4.191672e-05 4.378 0 0
Cellular responses to stress R-HSA-2262752 4.186278e-05 4.378 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 4.597939e-05 4.337 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.994079e-05 4.302 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.150666e-05 4.288 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 6.004981e-05 4.221 0 0
Death Receptor Signaling R-HSA-73887 6.030606e-05 4.220 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.636919e-05 4.178 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 7.799683e-05 4.108 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 8.627302e-05 4.064 0 0
NGF-stimulated transcription R-HSA-9031628 8.960257e-05 4.048 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 9.019475e-05 4.045 0 0
Chromatin modifying enzymes R-HSA-3247509 9.597878e-05 4.018 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.060281e-04 3.975 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.032125e-04 3.986 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.060281e-04 3.975 0 0
Nuclear import of Rev protein R-HSA-180746 1.111749e-04 3.954 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.124412e-04 3.949 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.516459e-04 3.819 0 0
M Phase R-HSA-68886 1.519375e-04 3.818 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.733889e-04 3.761 0 0
RUNX2 regulates bone development R-HSA-8941326 1.801607e-04 3.744 0 0
Cell Cycle Checkpoints R-HSA-69620 2.105419e-04 3.677 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.267314e-04 3.644 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.833005e-04 3.548 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.222029e-04 3.492 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.515651e-04 3.454 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 3.683848e-04 3.434 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.683848e-04 3.434 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 3.679407e-04 3.434 0 0
Cell Cycle, Mitotic R-HSA-69278 3.951342e-04 3.403 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 4.125441e-04 3.385 0 0
tRNA processing in the nucleus R-HSA-6784531 4.132650e-04 3.384 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.193531e-04 3.377 0 0
Formation of axial mesoderm R-HSA-9796292 4.219669e-04 3.375 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.139930e-04 3.383 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.334273e-04 3.363 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.360766e-04 3.360 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.817941e-04 3.317 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.310073e-04 3.275 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.310073e-04 3.275 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.387932e-04 3.269 0 0
Signaling by TGFBR3 R-HSA-9839373 5.617029e-04 3.250 0 0
Signaling by NTRKs R-HSA-166520 6.006855e-04 3.221 0 0
Cellular responses to stimuli R-HSA-8953897 6.088574e-04 3.215 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.366357e-04 3.196 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 6.806703e-04 3.167 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 7.017849e-04 3.154 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.349874e-04 3.134 0 0
Mitotic Prometaphase R-HSA-68877 7.559999e-04 3.121 0 0
ESR-mediated signaling R-HSA-8939211 7.644168e-04 3.117 0 0
Regulation of TP53 Expression R-HSA-6804754 8.167644e-04 3.088 0 0
Cardiogenesis R-HSA-9733709 8.210959e-04 3.086 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 8.068194e-04 3.093 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.210959e-04 3.086 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.986492e-04 3.046 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.578162e-04 3.067 0 0
Epigenetic regulation of gene expression R-HSA-212165 8.301829e-04 3.081 0 0
MAP kinase activation R-HSA-450294 9.326936e-04 3.030 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.986492e-04 3.046 0 0
Signaling by TGFB family members R-HSA-9006936 9.463668e-04 3.024 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 9.592983e-04 3.018 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.969953e-04 3.001 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.040404e-03 2.983 0 0
Heme signaling R-HSA-9707616 1.085984e-03 2.964 0 0
NRAGE signals death through JNK R-HSA-193648 1.119549e-03 2.951 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.132206e-03 2.946 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.227255e-03 2.911 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.248470e-03 2.904 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.248470e-03 2.904 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.348786e-03 2.870 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.325710e-03 2.878 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.345492e-03 2.871 0 0
HIV Life Cycle R-HSA-162587 1.386382e-03 2.858 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 1.497390e-03 2.825 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.497390e-03 2.825 0 0
Adipogenesis R-HSA-9843745 1.505564e-03 2.822 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 1.533362e-03 2.814 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.595423e-03 2.797 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.611355e-03 2.793 0 0
snRNP Assembly R-HSA-191859 1.767896e-03 2.753 0 0
Metabolism of non-coding RNA R-HSA-194441 1.767896e-03 2.753 0 0
Circadian clock R-HSA-9909396 1.656557e-03 2.781 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.841262e-03 2.735 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.878010e-03 2.726 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 2.061873e-03 2.686 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.076755e-03 2.683 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.096971e-03 2.678 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.096971e-03 2.678 0 0
Specification of primordial germ cells R-HSA-9827857 2.142383e-03 2.669 0 0
Signaling by Hippo R-HSA-2028269 2.142383e-03 2.669 0 0
DNA Double Strand Break Response R-HSA-5693606 2.212067e-03 2.655 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.444054e-03 2.612 0 0
Separation of Sister Chromatids R-HSA-2467813 2.507915e-03 2.601 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.344445e-03 2.630 0 0
Mitotic Anaphase R-HSA-68882 2.676965e-03 2.572 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 2.870672e-03 2.542 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.162738e-03 2.500 0 0
Interleukin-17 signaling R-HSA-448424 3.268930e-03 2.486 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.326918e-03 2.478 0 0
HIV Infection R-HSA-162906 3.344099e-03 2.476 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 3.526525e-03 2.453 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.526850e-03 2.453 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 3.743135e-03 2.427 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 3.743135e-03 2.427 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 3.743135e-03 2.427 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.133940e-03 2.384 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 4.182885e-03 2.379 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.347572e-03 2.362 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.347572e-03 2.362 0 0
DNA Repair R-HSA-73894 4.431856e-03 2.353 1 0
Oncogene Induced Senescence R-HSA-2559585 4.466786e-03 2.350 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.751764e-03 2.323 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 4.753240e-03 2.323 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.947221e-03 2.306 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 5.023947e-03 2.299 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.159610e-03 2.287 0 0
Homology Directed Repair R-HSA-5693538 5.455748e-03 2.263 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.622088e-03 2.250 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 6.036292e-03 2.219 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 6.036292e-03 2.219 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.324531e-03 2.199 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 6.200229e-03 2.208 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.324531e-03 2.199 0 0
Signaling by NOTCH3 R-HSA-9012852 6.089554e-03 2.215 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 6.435151e-03 2.191 0 0
Signaling by NOTCH1 R-HSA-1980143 6.641937e-03 2.178 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 6.718381e-03 2.173 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.073744e-03 2.150 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.506982e-03 2.125 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 7.551623e-03 2.122 0 0
Signaling by NOTCH R-HSA-157118 7.575064e-03 2.121 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 8.234887e-03 2.084 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 9.517134e-03 2.021 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 9.517134e-03 2.021 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 9.517134e-03 2.021 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.514317e-03 2.070 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.981967e-03 2.047 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 8.902102e-03 2.051 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.573324e-03 2.019 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.573324e-03 2.019 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.573324e-03 2.019 0 0
Reproduction R-HSA-1474165 9.404417e-03 2.027 0 0
Regulation of beta-cell development R-HSA-186712 1.003873e-02 1.998 0 0
HATs acetylate histones R-HSA-3214847 1.047971e-02 1.980 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.125947e-02 1.948 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 1.103561e-02 1.957 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.128613e-02 1.947 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.128613e-02 1.947 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.128613e-02 1.947 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.128613e-02 1.947 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.128613e-02 1.947 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.147859e-02 1.940 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 1.158066e-02 1.936 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.066098e-02 1.972 0 0
Mitotic Prophase R-HSA-68875 1.202738e-02 1.920 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.068462e-02 1.971 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.063986e-02 1.973 0 0
Diseases of DNA repair R-HSA-9675135 1.056928e-02 1.976 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.204676e-02 1.919 0 0
Signaling by ALK in cancer R-HSA-9700206 1.204676e-02 1.919 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.239997e-02 1.907 0 0
G2/M Checkpoints R-HSA-69481 1.241134e-02 1.906 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.261862e-02 1.899 0 0
Transcription of the HIV genome R-HSA-167172 1.268415e-02 1.897 0 0
p75NTR signals via NF-kB R-HSA-193639 1.404353e-02 1.853 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.404353e-02 1.853 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.404353e-02 1.853 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.515934e-02 1.819 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.515934e-02 1.819 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.515934e-02 1.819 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.515934e-02 1.819 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.562709e-02 1.806 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.799972e-02 1.745 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.799972e-02 1.745 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.832943e-02 1.737 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.572909e-02 1.803 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 1.615223e-02 1.792 0 0
Meiosis R-HSA-1500620 1.646947e-02 1.783 0 0
Deubiquitination R-HSA-5688426 1.727049e-02 1.763 0 0
TNF signaling R-HSA-75893 1.572909e-02 1.803 0 0
Host Interactions of HIV factors R-HSA-162909 1.633458e-02 1.787 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.595520e-02 1.797 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.725048e-02 1.763 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.957787e-02 1.708 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.957787e-02 1.708 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.986495e-02 1.702 0 0
PTK6 Expression R-HSA-8849473 1.986495e-02 1.702 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.121037e-02 1.673 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 2.121037e-02 1.673 0 0
mRNA 3'-end processing R-HSA-72187 2.193408e-02 1.659 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.193408e-02 1.659 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 2.193792e-02 1.659 0 0
Gene Silencing by RNA R-HSA-211000 2.208839e-02 1.656 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 2.231710e-02 1.651 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.233322e-02 1.651 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 2.382618e-02 1.623 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.397048e-02 1.620 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.402394e-02 1.619 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.431889e-02 1.614 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.493613e-02 1.603 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 2.566653e-02 1.591 0 0
NOD1/2 Signaling Pathway R-HSA-168638 2.635980e-02 1.579 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.638875e-02 1.579 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.675824e-02 1.573 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 2.690517e-02 1.570 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.690517e-02 1.570 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 3.115349e-02 1.506 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 3.115349e-02 1.506 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.172582e-02 1.499 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.061074e-02 1.514 0 0
HIV Transcription Initiation R-HSA-167161 3.061074e-02 1.514 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.061074e-02 1.514 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 3.018077e-02 1.520 0 0
PTEN Regulation R-HSA-6807070 3.245366e-02 1.489 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.172582e-02 1.499 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.794503e-02 1.554 0 0
Co-inhibition by PD-1 R-HSA-389948 2.887171e-02 1.540 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.172582e-02 1.499 0 0
G alpha (12/13) signalling events R-HSA-416482 3.287923e-02 1.483 0 0
Activation of BH3-only proteins R-HSA-114452 3.292990e-02 1.482 0 0
Regulation of TP53 Degradation R-HSA-6804757 3.405433e-02 1.468 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.412280e-02 1.467 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 3.434168e-02 1.464 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.438316e-02 1.464 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.438316e-02 1.464 0 0
WNT mediated activation of DVL R-HSA-201688 3.526213e-02 1.453 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 3.526213e-02 1.453 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 3.537222e-02 1.451 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 3.537222e-02 1.451 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 3.537222e-02 1.451 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.537222e-02 1.451 0 0
FOXO-mediated transcription R-HSA-9614085 3.568892e-02 1.447 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.687876e-02 1.433 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.772008e-02 1.423 0 0
Rap1 signalling R-HSA-392517 3.772008e-02 1.423 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.772008e-02 1.423 1 0
IKBKB deficiency causes SCID R-HSA-5602636 3.790808e-02 1.421 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 3.790808e-02 1.421 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.826242e-02 1.417 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.826242e-02 1.417 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 3.829443e-02 1.417 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.837860e-02 1.416 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.049765e-02 1.393 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.088870e-02 1.388 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.123282e-02 1.385 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 4.123282e-02 1.385 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 4.123282e-02 1.385 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.174871e-02 1.379 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.174871e-02 1.379 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 4.908727e-02 1.309 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 4.628524e-02 1.335 1 1
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 4.628524e-02 1.335 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 4.628524e-02 1.335 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.523415e-02 1.258 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 4.439174e-02 1.353 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.405575e-02 1.267 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 4.740821e-02 1.324 0 0
Meiotic synapsis R-HSA-1221632 5.062568e-02 1.296 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.303200e-02 1.275 0 0
PPARA activates gene expression R-HSA-1989781 5.372061e-02 1.270 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 5.421044e-02 1.266 0 0
Nuclear RNA decay R-HSA-9930044 4.842502e-02 1.315 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.448909e-02 1.264 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.842502e-02 1.315 0 0
Cell junction organization R-HSA-446728 4.922757e-02 1.308 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.393943e-02 1.268 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.393943e-02 1.268 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 4.439174e-02 1.353 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.842502e-02 1.315 0 0
Signaling by NOTCH4 R-HSA-9013694 4.423219e-02 1.354 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 4.628524e-02 1.335 0 0
Formation of paraxial mesoderm R-HSA-9793380 5.303200e-02 1.275 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.842502e-02 1.315 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.175572e-02 1.286 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.094842e-02 1.293 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.599704e-02 1.252 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 5.773524e-02 1.239 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.776557e-02 1.238 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 5.932702e-02 1.227 1 1
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.982154e-02 1.223 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.036077e-02 1.219 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.036077e-02 1.219 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 6.101739e-02 1.215 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.130464e-02 1.213 0 0
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization R-HSA-180897 6.311740e-02 1.200 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.500478e-02 1.187 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.511150e-02 1.186 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.511150e-02 1.186 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.511150e-02 1.186 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.511150e-02 1.186 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.599262e-02 1.181 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.780358e-02 1.169 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 6.795793e-02 1.168 0 0
PERK regulates gene expression R-HSA-381042 6.801549e-02 1.167 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 6.835547e-02 1.165 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 6.835547e-02 1.165 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 6.835547e-02 1.165 0 0
NF-kB is activated and signals survival R-HSA-209560 6.835547e-02 1.165 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.859338e-02 1.164 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.859338e-02 1.164 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 6.911975e-02 1.160 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.924389e-02 1.160 0 0
Adherens junctions interactions R-HSA-418990 7.058653e-02 1.151 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.470236e-02 1.127 0 0
HSF1 activation R-HSA-3371511 7.548672e-02 1.122 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.591028e-02 1.120 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.591028e-02 1.120 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 9.649617e-02 1.015 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 9.649617e-02 1.015 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 9.649617e-02 1.015 0 0
MET interacts with TNS proteins R-HSA-8875513 9.242048e-02 1.034 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 9.242048e-02 1.034 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 9.242048e-02 1.034 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 8.297127e-02 1.081 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 8.297127e-02 1.081 0 0
Type I hemidesmosome assembly R-HSA-446107 1.028039e-01 0.988 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 1.028039e-01 0.988 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.199618e-02 1.086 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 9.686509e-02 1.014 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 9.686509e-02 1.014 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 9.686509e-02 1.014 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 9.686509e-02 1.014 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.002005e-01 0.999 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.750292e-02 1.111 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.974642e-02 1.047 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.720532e-02 1.012 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 9.840921e-02 1.007 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 9.686509e-02 1.014 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.199618e-02 1.086 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 9.596430e-02 1.018 0 0
Sema4D in semaphorin signaling R-HSA-400685 9.910834e-02 1.004 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 9.140717e-02 1.039 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.441097e-02 1.074 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 9.739223e-02 1.011 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 8.824548e-02 1.054 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 7.979982e-02 1.098 0 0
Developmental Biology R-HSA-1266738 7.910347e-02 1.102 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 9.686509e-02 1.014 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 8.449857e-02 1.073 0 0
Inhibition of nitric oxide production R-HSA-9636249 9.242048e-02 1.034 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 9.523138e-02 1.021 0 0
Signaling by ALK R-HSA-201556 1.007390e-01 0.997 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.035535e-01 0.985 0 0
Apoptotic execution phase R-HSA-75153 1.035535e-01 0.985 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.100914e-01 0.958 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 1.106429e-01 0.956 0 0
Myogenesis R-HSA-525793 1.106429e-01 0.956 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.106429e-01 0.956 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.128949e-01 0.947 0 0
Removal of the Flap Intermediate R-HSA-69166 1.128949e-01 0.947 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 1.128949e-01 0.947 0 0
Physiological factors R-HSA-5578768 1.128949e-01 0.947 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.128949e-01 0.947 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.131932e-01 0.946 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.131932e-01 0.946 0 0
Negative regulation of MET activity R-HSA-6807004 1.136365e-01 0.944 0 0
Signaling by NODAL R-HSA-1181150 1.136365e-01 0.944 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.166389e-01 0.933 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.200696e-01 0.921 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.200696e-01 0.921 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 1.228291e-01 0.911 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.230073e-01 0.910 0 0
Selective autophagy R-HSA-9663891 1.236812e-01 0.908 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.243013e-01 0.906 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.243013e-01 0.906 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.243013e-01 0.906 0 0
ALK mutants bind TKIs R-HSA-9700645 1.243013e-01 0.906 0 0
Calcineurin activates NFAT R-HSA-2025928 1.243013e-01 0.906 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.243013e-01 0.906 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.243013e-01 0.906 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 1.243013e-01 0.906 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.243013e-01 0.906 0 0
NADE modulates death signalling R-HSA-205025 1.247935e-01 0.904 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.247935e-01 0.904 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.247935e-01 0.904 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 1.247935e-01 0.904 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.247935e-01 0.904 0 0
Mitochondrial biogenesis R-HSA-1592230 1.254463e-01 0.902 0 0
Cell-cell junction organization R-HSA-421270 1.258420e-01 0.900 0 0
Dual Incision in GG-NER R-HSA-5696400 1.277774e-01 0.894 0 0
Signaling by NOTCH2 R-HSA-1980145 1.277774e-01 0.894 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 1.277774e-01 0.894 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.278847e-01 0.893 0 0
ERK/MAPK targets R-HSA-198753 1.278847e-01 0.893 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.278847e-01 0.893 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 1.300075e-01 0.886 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.300075e-01 0.886 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.300075e-01 0.886 0 0
Signaling by Activin R-HSA-1502540 1.300075e-01 0.886 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 1.301564e-01 0.886 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.836860e-01 0.736 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.836860e-01 0.736 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.836860e-01 0.736 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.836860e-01 0.736 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.836860e-01 0.736 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.593720e-01 0.798 0 0
IRS activation R-HSA-74713 1.593720e-01 0.798 0 0
G2 Phase R-HSA-68911 1.593720e-01 0.798 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.593720e-01 0.798 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.954295e-01 0.709 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.954295e-01 0.709 0 0
Signaling by RNF43 mutants R-HSA-5340588 1.954295e-01 0.709 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.714420e-01 0.766 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 1.714420e-01 0.766 0 0
Phosphorylation of the APC/C R-HSA-176412 1.481163e-01 0.829 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 1.671286e-01 0.777 0 0
HIV elongation arrest and recovery R-HSA-167287 1.356427e-01 0.868 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.356427e-01 0.868 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 1.750421e-01 0.757 0 0
Deadenylation of mRNA R-HSA-429947 1.920577e-01 0.717 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.920577e-01 0.717 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.380338e-01 0.860 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.876743e-01 0.727 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.725880e-01 0.763 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.590802e-01 0.798 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.868982e-01 0.728 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.868982e-01 0.728 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.868982e-01 0.728 0 0
Prolonged ERK activation events R-HSA-169893 1.481163e-01 0.829 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 1.671286e-01 0.777 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.796714e-01 0.746 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 1.481163e-01 0.829 0 0
Stabilization of p53 R-HSA-69541 1.907594e-01 0.720 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.920577e-01 0.717 0 0
Interleukin-1 signaling R-HSA-9020702 1.730580e-01 0.762 0 0
Formation of lateral plate mesoderm R-HSA-9758920 1.954295e-01 0.709 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.838736e-01 0.735 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.752558e-01 0.756 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.954295e-01 0.709 0 0
Cell-Cell communication R-HSA-1500931 1.736470e-01 0.760 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 1.481163e-01 0.829 0 0
Neurexins and neuroligins R-HSA-6794361 1.616342e-01 0.791 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.305772e-01 0.884 0 0
MTOR signalling R-HSA-165159 1.408477e-01 0.851 0 0
Signaling by WNT R-HSA-195721 1.349372e-01 0.870 0 0
Formation of intermediate mesoderm R-HSA-9761174 1.472521e-01 0.832 0 0
Metabolism of RNA R-HSA-8953854 1.698961e-01 0.770 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.836860e-01 0.736 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.593720e-01 0.798 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.472521e-01 0.832 0 0
Disorders of Developmental Biology R-HSA-9675151 1.671286e-01 0.777 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.429014e-01 0.845 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.641948e-01 0.785 0 0
Toll-like Receptor Cascades R-HSA-168898 1.303269e-01 0.885 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.478256e-01 0.830 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.750421e-01 0.757 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.593720e-01 0.798 0 0
Josephin domain DUBs R-HSA-5689877 1.472521e-01 0.832 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.568567e-01 0.804 0 0
NrCAM interactions R-HSA-447038 1.593720e-01 0.798 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.634812e-01 0.787 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 1.907594e-01 0.720 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.593720e-01 0.798 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 1.954295e-01 0.709 0 0
Glycolysis R-HSA-70171 1.650570e-01 0.782 0 0
Activation of RAC1 R-HSA-428540 1.966586e-01 0.706 0 0
Inositol phosphate metabolism R-HSA-1483249 1.999374e-01 0.699 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 2.038695e-01 0.691 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.046529e-01 0.689 0 0
Attenuation phase R-HSA-3371568 2.046529e-01 0.689 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.046529e-01 0.689 0 0
Aggrephagy R-HSA-9646399 2.046529e-01 0.689 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.059833e-01 0.686 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.073813e-01 0.683 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.073813e-01 0.683 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.074721e-01 0.683 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.080517e-01 0.682 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.095056e-01 0.679 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.168673e-01 0.664 0 0
Apoptosis R-HSA-109581 2.182904e-01 0.661 0 0
Repression of WNT target genes R-HSA-4641265 2.226959e-01 0.652 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.226959e-01 0.652 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.226959e-01 0.652 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.226959e-01 0.652 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.239514e-01 0.650 0 0
DNA Damage Bypass R-HSA-73893 2.265557e-01 0.645 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.265557e-01 0.645 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.265557e-01 0.645 0 0
Centrosome maturation R-HSA-380287 2.276606e-01 0.643 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 2.276606e-01 0.643 0 0
Metalloprotease DUBs R-HSA-5689901 2.276884e-01 0.643 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 2.624664e-01 0.581 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 2.624664e-01 0.581 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.624664e-01 0.581 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.624664e-01 0.581 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 2.624664e-01 0.581 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.624664e-01 0.581 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.336482e-01 0.477 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.336482e-01 0.477 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.336482e-01 0.477 0 0
Signalling to ERK5 R-HSA-198765 3.336482e-01 0.477 0 0
TGFBR3 regulates activin signaling R-HSA-9839406 3.336482e-01 0.477 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.336482e-01 0.477 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.336482e-01 0.477 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.336482e-01 0.477 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.336482e-01 0.477 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 3.336482e-01 0.477 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.336482e-01 0.477 0 0
Defective ALG14 causes ALG14-CMS R-HSA-5633231 3.336482e-01 0.477 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.336482e-01 0.477 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.336482e-01 0.477 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.336482e-01 0.477 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.336482e-01 0.477 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.323590e-01 0.634 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 2.323590e-01 0.634 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 2.696570e-01 0.569 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 2.696570e-01 0.569 0 0
Regulation of PTEN localization R-HSA-8948747 2.696570e-01 0.569 0 0
SOS-mediated signalling R-HSA-112412 2.696570e-01 0.569 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 2.696570e-01 0.569 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 2.696570e-01 0.569 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 2.696570e-01 0.569 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 2.696570e-01 0.569 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.696570e-01 0.569 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 3.979638e-01 0.400 0 0
The NLRP1 inflammasome R-HSA-844455 3.979638e-01 0.400 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.979638e-01 0.400 0 0
TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866906 3.979638e-01 0.400 0 0
Axonal growth stimulation R-HSA-209563 3.979638e-01 0.400 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 3.979638e-01 0.400 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.979638e-01 0.400 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.069086e-01 0.513 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.069086e-01 0.513 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.069086e-01 0.513 0 0
Translesion Synthesis by POLH R-HSA-110320 2.286031e-01 0.641 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.286031e-01 0.641 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.286031e-01 0.641 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.437757e-01 0.464 0 0
ARMS-mediated activation R-HSA-170984 3.437757e-01 0.464 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.437757e-01 0.464 0 0
HCN channels R-HSA-1296061 4.560751e-01 0.341 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.560751e-01 0.341 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.560751e-01 0.341 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 4.560751e-01 0.341 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 4.560751e-01 0.341 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.560751e-01 0.341 0 0
Defective FMO3 causes TMAU R-HSA-5579019 4.560751e-01 0.341 0 0
Signaling by LRP5 mutants R-HSA-5339717 4.560751e-01 0.341 0 0
DCC mediated attractive signaling R-HSA-418885 3.038225e-01 0.517 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 3.038225e-01 0.517 0 0
2-LTR circle formation R-HSA-164843 3.799858e-01 0.420 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 3.799858e-01 0.420 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 3.799858e-01 0.420 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.461827e-01 0.609 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.461827e-01 0.609 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.946388e-01 0.531 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.946388e-01 0.531 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.946388e-01 0.531 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 2.650479e-01 0.577 0 0
Formation of the Early Elongation Complex R-HSA-113418 2.650479e-01 0.577 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.842227e-01 0.546 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.153224e-01 0.382 0 0
Dual incision in TC-NER R-HSA-6782135 2.320296e-01 0.634 0 0
Degradation of DVL R-HSA-4641258 2.909366e-01 0.536 0 0
HSF1-dependent transactivation R-HSA-3371571 2.539539e-01 0.595 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.680269e-01 0.572 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.496170e-01 0.347 0 0
ERKs are inactivated R-HSA-202670 4.496170e-01 0.347 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.823171e-01 0.549 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.823171e-01 0.549 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 3.258705e-01 0.487 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.129804e-01 0.384 0 0
HIV Transcription Elongation R-HSA-167169 3.435513e-01 0.464 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.435513e-01 0.464 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.435513e-01 0.464 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 3.435513e-01 0.464 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.266128e-01 0.486 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.114512e-01 0.507 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 2.976975e-01 0.526 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 2.734577e-01 0.563 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.262458e-01 0.486 0 0
Striated Muscle Contraction R-HSA-390522 3.826771e-01 0.417 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.850963e-01 0.545 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 4.304449e-01 0.366 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.367479e-01 0.473 0 0
PRC2 methylates histones and DNA R-HSA-212300 4.418588e-01 0.355 0 0
Nucleosome assembly R-HSA-774815 4.501713e-01 0.347 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.501713e-01 0.347 0 0
HCMV Early Events R-HSA-9609690 3.471213e-01 0.460 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.106925e-01 0.386 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 3.006561e-01 0.522 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.850952e-01 0.545 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.850952e-01 0.545 0 0
Cellular response to hypoxia R-HSA-1234174 3.251793e-01 0.488 0 0
Nucleotide Excision Repair R-HSA-5696398 3.046167e-01 0.516 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 3.613206e-01 0.442 0 0
Pexophagy R-HSA-9664873 3.799858e-01 0.420 0 0
Lagging Strand Synthesis R-HSA-69186 2.722836e-01 0.565 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.672072e-01 0.435 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.301944e-01 0.638 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.437757e-01 0.464 0 0
Termination of translesion DNA synthesis R-HSA-5656169 2.842227e-01 0.546 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.080969e-01 0.511 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.437757e-01 0.464 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.024956e-01 0.395 0 0
Chromosome Maintenance R-HSA-73886 3.006561e-01 0.522 0 0
Developmental Cell Lineages R-HSA-9734767 4.297097e-01 0.367 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.947523e-01 0.531 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.841774e-01 0.546 0 0
Regulation of necroptotic cell death R-HSA-5675482 3.628307e-01 0.440 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 4.097291e-01 0.388 0 0
Frs2-mediated activation R-HSA-170968 2.493572e-01 0.603 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.069086e-01 0.513 0 0
PCP/CE pathway R-HSA-4086400 2.617345e-01 0.582 0 0
Extension of Telomeres R-HSA-180786 3.712451e-01 0.430 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.312953e-01 0.480 0 0
UCH proteinases R-HSA-5689603 2.388231e-01 0.622 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.437757e-01 0.464 0 0
PI3K/AKT activation R-HSA-198203 3.799858e-01 0.420 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.153224e-01 0.382 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.496170e-01 0.347 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 2.946388e-01 0.531 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 2.696570e-01 0.569 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 3.069086e-01 0.513 0 0
Regulation of gap junction activity R-HSA-191650 4.560751e-01 0.341 0 0
Telomere C-strand synthesis initiation R-HSA-174430 3.038225e-01 0.517 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.304449e-01 0.366 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.418588e-01 0.355 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.720975e-01 0.429 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 3.172127e-01 0.499 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.850952e-01 0.545 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.346561e-01 0.630 0 0
Meiotic recombination R-HSA-912446 2.539539e-01 0.595 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.915785e-01 0.407 0 0
COPII-mediated vesicle transport R-HSA-204005 3.955323e-01 0.403 0 0
Killing mechanisms R-HSA-9664420 3.312953e-01 0.480 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.312953e-01 0.480 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.496170e-01 0.347 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.853880e-01 0.414 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.976975e-01 0.526 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.969694e-01 0.401 0 0
Signaling by ROBO receptors R-HSA-376176 2.573180e-01 0.590 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 4.032802e-01 0.394 0 0
Signaling by BMP R-HSA-201451 4.304449e-01 0.366 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 3.038225e-01 0.517 0 0
Lipophagy R-HSA-9613354 3.437757e-01 0.464 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.560751e-01 0.341 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.560751e-01 0.341 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 4.560751e-01 0.341 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.401222e-01 0.620 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 3.859975e-01 0.413 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 4.496170e-01 0.347 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 4.024956e-01 0.395 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.934822e-01 0.405 0 0
Signalling to ERKs R-HSA-187687 4.222380e-01 0.374 0 0
Synthesis of DNA R-HSA-69239 4.326592e-01 0.364 0 0
Cellular response to chemical stress R-HSA-9711123 3.949575e-01 0.403 0 0
Interleukin-1 family signaling R-HSA-446652 2.835448e-01 0.547 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 3.232611e-01 0.490 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.613206e-01 0.442 0 0
Hedgehog 'on' state R-HSA-5632684 4.097291e-01 0.388 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.868148e-01 0.412 0 0
Semaphorin interactions R-HSA-373755 4.317937e-01 0.365 0 0
Inhibition of Host mRNA Processing and RNA Silencing R-HSA-168315 2.624664e-01 0.581 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.336482e-01 0.477 0 0
Influenza Virus Induced Apoptosis R-HSA-168277 3.336482e-01 0.477 0 0
C6 deamination of adenosine R-HSA-75102 3.336482e-01 0.477 0 0
Adenosine P1 receptors R-HSA-417973 3.979638e-01 0.400 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 3.979638e-01 0.400 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 3.979638e-01 0.400 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.560751e-01 0.341 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.038225e-01 0.517 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 2.722836e-01 0.565 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.799858e-01 0.420 0 0
Differentiation of T cells R-HSA-9945266 3.312953e-01 0.480 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 3.312953e-01 0.480 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 4.153224e-01 0.382 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.153224e-01 0.382 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 3.859975e-01 0.413 0 0
Signaling by EGFR R-HSA-177929 3.262458e-01 0.486 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.826771e-01 0.417 0 0
MHC class II antigen presentation R-HSA-2132295 3.204823e-01 0.494 0 0
S Phase R-HSA-69242 2.502357e-01 0.602 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.653866e-01 0.437 0 0
Ub-specific processing proteases R-HSA-5689880 2.396013e-01 0.621 0 0
Membrane Trafficking R-HSA-199991 4.135551e-01 0.383 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.861306e-01 0.413 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.408326e-01 0.618 0 0
Macroautophagy R-HSA-1632852 4.372813e-01 0.359 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 3.437757e-01 0.464 0 0
G0 and Early G1 R-HSA-1538133 3.430076e-01 0.465 0 0
Receptor Mediated Mitophagy R-HSA-8934903 3.799858e-01 0.420 0 0
Signal attenuation R-HSA-74749 3.799858e-01 0.420 0 0
Formation of the ureteric bud R-HSA-9830674 3.399171e-01 0.469 0 0
TBC/RABGAPs R-HSA-8854214 2.636384e-01 0.579 0 0
Long-term potentiation R-HSA-9620244 3.853880e-01 0.414 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 3.628307e-01 0.440 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 3.768175e-01 0.424 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.764569e-01 0.558 0 0
Cell-extracellular matrix interactions R-HSA-446353 3.038225e-01 0.517 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.380985e-01 0.358 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.292624e-01 0.482 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 4.080027e-01 0.389 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.304449e-01 0.366 0 0
G2/M Transition R-HSA-69275 3.425824e-01 0.465 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.624664e-01 0.581 0 0
DSCAM interactions R-HSA-376172 3.336482e-01 0.477 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.560751e-01 0.341 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.560751e-01 0.341 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.038225e-01 0.517 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.859975e-01 0.413 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 3.626684e-01 0.440 0 0
RSV-host interactions R-HSA-9833110 3.977372e-01 0.400 0 0
Programmed Cell Death R-HSA-5357801 3.514077e-01 0.454 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.210118e-01 0.376 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.323590e-01 0.634 0 0
Suppression of apoptosis R-HSA-9635465 4.153224e-01 0.382 0 0
Interleukin-37 signaling R-HSA-9008059 3.036469e-01 0.518 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.479655e-01 0.606 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.428010e-01 0.615 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.696570e-01 0.569 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.560751e-01 0.341 0 0
Synaptic adhesion-like molecules R-HSA-8849932 4.129804e-01 0.384 0 0
Sensory processing of sound R-HSA-9659379 3.898865e-01 0.409 0 0
Prostanoid ligand receptors R-HSA-391908 4.153224e-01 0.382 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.859975e-01 0.413 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.559243e-01 0.341 0 0
Integration of provirus R-HSA-162592 4.496170e-01 0.347 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.069086e-01 0.513 0 0
Interleukin-1 processing R-HSA-448706 3.437757e-01 0.464 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.859975e-01 0.413 0 0
Cytoprotection by HMOX1 R-HSA-9707564 3.218195e-01 0.492 0 0
Mismatch Repair R-HSA-5358508 4.129804e-01 0.384 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.946388e-01 0.531 0 0
Interleukin-7 signaling R-HSA-1266695 3.853880e-01 0.414 0 0
Signaling by Leptin R-HSA-2586552 3.799858e-01 0.420 0 0
tRNA processing R-HSA-72306 3.678911e-01 0.434 0 0
Glucose metabolism R-HSA-70326 3.547617e-01 0.450 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 2.402317e-01 0.619 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.568185e-01 0.340 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 4.656961e-01 0.332 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.656961e-01 0.332 0 0
TCR signaling R-HSA-202403 4.675224e-01 0.330 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.676985e-01 0.330 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 4.676985e-01 0.330 0 0
Regulation of gene expression in beta cells R-HSA-210745 4.745694e-01 0.324 0 0
Nervous system development R-HSA-9675108 4.757588e-01 0.323 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 4.805686e-01 0.318 0 0
Polymerase switching R-HSA-69091 4.827415e-01 0.316 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 4.827415e-01 0.316 0 0
Leading Strand Synthesis R-HSA-69109 4.827415e-01 0.316 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.827415e-01 0.316 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.827415e-01 0.316 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.827415e-01 0.316 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.827415e-01 0.316 0 0
Signaling by LTK R-HSA-9842663 4.827415e-01 0.316 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.827415e-01 0.316 0 0
Disorders of Nervous System Development R-HSA-9697154 4.827415e-01 0.316 0 0
Pervasive developmental disorders R-HSA-9005895 4.827415e-01 0.316 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.857303e-01 0.314 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.886717e-01 0.311 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.895059e-01 0.310 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 4.912623e-01 0.309 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.961444e-01 0.304 0 0
Activation of the pre-replicative complex R-HSA-68962 4.961444e-01 0.304 0 0
XBP1(S) activates chaperone genes R-HSA-381038 4.965222e-01 0.304 0 0
Autophagy R-HSA-9612973 4.992267e-01 0.302 0 0
mRNA Splicing R-HSA-72172 5.056364e-01 0.296 0 0
ER to Golgi Anterograde Transport R-HSA-199977 5.077020e-01 0.294 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.085804e-01 0.294 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.085804e-01 0.294 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.085804e-01 0.294 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.085804e-01 0.294 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.085804e-01 0.294 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.085804e-01 0.294 0 0
Defective F9 activation R-HSA-9673221 5.085804e-01 0.294 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.085804e-01 0.294 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.085804e-01 0.294 0 0
Activation of AKT2 R-HSA-165158 5.085804e-01 0.294 0 0
Reelin signalling pathway R-HSA-8866376 5.085804e-01 0.294 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 5.085804e-01 0.294 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.085804e-01 0.294 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.085804e-01 0.294 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.085804e-01 0.294 0 0
HCMV Late Events R-HSA-9610379 5.089112e-01 0.293 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.146023e-01 0.289 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.146023e-01 0.289 0 0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 5.146023e-01 0.289 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.146023e-01 0.289 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.146023e-01 0.289 0 0
Maturation of nucleoprotein R-HSA-9683610 5.146023e-01 0.289 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.162097e-01 0.287 0 0
EGFR downregulation R-HSA-182971 5.173324e-01 0.286 0 0
Trafficking of AMPA receptors R-HSA-399719 5.173324e-01 0.286 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 5.183213e-01 0.285 0 0
Diseases of Immune System R-HSA-5260271 5.183213e-01 0.285 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.183213e-01 0.285 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.183213e-01 0.285 0 0
Degradation of CDH1 R-HSA-9766229 5.192455e-01 0.285 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 5.217856e-01 0.283 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.353633e-01 0.271 0 0
Signaling by MET R-HSA-6806834 5.353633e-01 0.271 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.355847e-01 0.271 0 0
Kinesins R-HSA-983189 5.355847e-01 0.271 0 0
Telomere Maintenance R-HSA-157579 5.355888e-01 0.271 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.367572e-01 0.270 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 5.367572e-01 0.270 0 0
Signaling by WNT in cancer R-HSA-4791275 5.380933e-01 0.269 0 0
DNA strand elongation R-HSA-69190 5.380933e-01 0.269 0 0
Influenza Infection R-HSA-168255 5.384418e-01 0.269 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.404838e-01 0.267 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.404838e-01 0.267 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.451349e-01 0.263 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.451349e-01 0.263 0 0
Regulation of KIT signaling R-HSA-1433559 5.451349e-01 0.263 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 5.496562e-01 0.260 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 5.524950e-01 0.258 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.548620e-01 0.256 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 5.560201e-01 0.255 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.560201e-01 0.255 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.560201e-01 0.255 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.560201e-01 0.255 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.560201e-01 0.255 0 0
Phosphorylation of Emi1 R-HSA-176417 5.560201e-01 0.255 0 0
Defective CSF2RB causes SMDP5 R-HSA-5688849 5.560201e-01 0.255 0 0
Defective CSF2RA causes SMDP4 R-HSA-5688890 5.560201e-01 0.255 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.560201e-01 0.255 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.560201e-01 0.255 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.560201e-01 0.255 0 0
NGF-independant TRKA activation R-HSA-187024 5.560201e-01 0.255 0 0
Ceramide signalling R-HSA-193681 5.560201e-01 0.255 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.560201e-01 0.255 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.560201e-01 0.255 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.560201e-01 0.255 0 0
Relaxin receptors R-HSA-444821 5.560201e-01 0.255 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 5.560201e-01 0.255 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.560201e-01 0.255 0 0
Integrin signaling R-HSA-354192 5.583923e-01 0.253 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.583923e-01 0.253 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 5.583923e-01 0.253 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.583923e-01 0.253 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.640403e-01 0.249 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.640403e-01 0.249 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 5.640403e-01 0.249 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 5.687195e-01 0.245 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 5.687195e-01 0.245 0 0
Rab regulation of trafficking R-HSA-9007101 5.692607e-01 0.245 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.715956e-01 0.243 0 0
IRE1alpha activates chaperones R-HSA-381070 5.732456e-01 0.242 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 5.732460e-01 0.242 0 0
Erythropoietin activates RAS R-HSA-9027284 5.742987e-01 0.241 0 0
Translesion synthesis by REV1 R-HSA-110312 5.742987e-01 0.241 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.742987e-01 0.241 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.742987e-01 0.241 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.781993e-01 0.238 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 5.781993e-01 0.238 0 0
Effects of PIP2 hydrolysis R-HSA-114508 5.781993e-01 0.238 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.834216e-01 0.234 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.846523e-01 0.233 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 5.846523e-01 0.233 0 0
EPH-Ephrin signaling R-HSA-2682334 5.855547e-01 0.232 0 0
Thromboxane signalling through TP receptor R-HSA-428930 5.868438e-01 0.231 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.868438e-01 0.231 0 0
Neurodegenerative Diseases R-HSA-8863678 5.868438e-01 0.231 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.950434e-01 0.225 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 5.974890e-01 0.224 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.977279e-01 0.223 0 0
Signaling by LTK in cancer R-HSA-9842640 5.988827e-01 0.223 0 0
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells R-HSA-210746 5.988827e-01 0.223 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.988827e-01 0.223 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 5.988827e-01 0.223 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 5.988827e-01 0.223 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.988827e-01 0.223 0 0
CREB phosphorylation R-HSA-199920 5.988827e-01 0.223 0 0
CREB3 factors activate genes R-HSA-8874211 5.988827e-01 0.223 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 6.020734e-01 0.220 0 0
Translesion synthesis by POLI R-HSA-5656121 6.020734e-01 0.220 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.020734e-01 0.220 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.020734e-01 0.220 0 0
Negative regulation of FLT3 R-HSA-9706369 6.020734e-01 0.220 0 0
Adaptive Immune System R-HSA-1280218 6.034039e-01 0.219 0 0
MAPK family signaling cascades R-HSA-5683057 6.041174e-01 0.219 0 0
Netrin-1 signaling R-HSA-373752 6.069603e-01 0.217 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.088677e-01 0.215 0 0
HDMs demethylate histones R-HSA-3214842 6.088677e-01 0.215 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 6.095200e-01 0.215 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 6.162405e-01 0.210 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 6.162405e-01 0.210 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 6.162405e-01 0.210 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 6.214772e-01 0.207 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.235250e-01 0.205 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 6.235250e-01 0.205 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.235250e-01 0.205 0 0
Somitogenesis R-HSA-9824272 6.235250e-01 0.205 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.235250e-01 0.205 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.235250e-01 0.205 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.284556e-01 0.202 0 0
Translesion synthesis by POLK R-HSA-5655862 6.284556e-01 0.202 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.284556e-01 0.202 0 0
Fibronectin matrix formation R-HSA-1566977 6.284556e-01 0.202 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 6.284556e-01 0.202 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 6.284556e-01 0.202 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.300928e-01 0.201 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.300928e-01 0.201 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.300928e-01 0.201 0 0
HCMV Infection R-HSA-9609646 6.324230e-01 0.199 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 6.326044e-01 0.199 0 0
GPVI-mediated activation cascade R-HSA-114604 6.344370e-01 0.198 0 0
RET signaling R-HSA-8853659 6.344370e-01 0.198 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.376095e-01 0.195 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 6.376095e-01 0.195 0 0
Netrin mediated repulsion signals R-HSA-418886 6.376095e-01 0.195 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.376095e-01 0.195 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.376095e-01 0.195 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.376095e-01 0.195 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.376095e-01 0.195 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.376095e-01 0.195 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.376095e-01 0.195 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.376095e-01 0.195 0 0
Activation of TRKA receptors R-HSA-187015 6.376095e-01 0.195 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.376095e-01 0.195 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.376095e-01 0.195 0 0
Post NMDA receptor activation events R-HSA-438064 6.379264e-01 0.195 0 0
Regulation of CDH1 Function R-HSA-9764561 6.451700e-01 0.190 0 0
SARS-CoV Infections R-HSA-9679506 6.461908e-01 0.190 0 0
Axon guidance R-HSA-422475 6.466356e-01 0.189 0 0
Diseases of programmed cell death R-HSA-9645723 6.498467e-01 0.187 0 0
Packaging Of Telomere Ends R-HSA-171306 6.505066e-01 0.187 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 6.505066e-01 0.187 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 6.505066e-01 0.187 0 0
Regulated Necrosis R-HSA-5218859 6.507122e-01 0.187 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 6.520653e-01 0.186 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 6.520653e-01 0.186 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 6.534550e-01 0.185 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 6.534550e-01 0.185 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 6.553673e-01 0.184 0 0
DNA Replication R-HSA-69306 6.608215e-01 0.180 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 6.701028e-01 0.174 0 0
Inflammasomes R-HSA-622312 6.701028e-01 0.174 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.706247e-01 0.174 0 0
Activation of RAS in B cells R-HSA-1169092 6.725995e-01 0.172 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.725995e-01 0.172 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.725995e-01 0.172 0 0
Formation of annular gap junctions R-HSA-196025 6.725995e-01 0.172 0 0
FGFR1b ligand binding and activation R-HSA-190370 6.725995e-01 0.172 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.725995e-01 0.172 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.725995e-01 0.172 0 0
Calcitonin-like ligand receptors R-HSA-419812 6.725995e-01 0.172 0 0
RSK activation R-HSA-444257 6.725995e-01 0.172 0 0
Downstream TCR signaling R-HSA-202424 6.730072e-01 0.172 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.766889e-01 0.170 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.770928e-01 0.169 0 0
Chaperone Mediated Autophagy R-HSA-9613829 6.770928e-01 0.169 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.770928e-01 0.169 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 6.770928e-01 0.169 0 0
Hedgehog 'off' state R-HSA-5610787 6.881825e-01 0.162 0 0
mRNA Capping R-HSA-72086 6.888807e-01 0.162 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 6.888807e-01 0.162 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 6.888807e-01 0.162 0 0
Organelle biogenesis and maintenance R-HSA-1852241 6.900153e-01 0.161 0 0
SLC transporter disorders R-HSA-5619102 6.913459e-01 0.160 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.993988e-01 0.155 0 0
Regulation of signaling by CBL R-HSA-912631 6.993988e-01 0.155 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.993988e-01 0.155 0 0
Specification of the neural plate border R-HSA-9834899 6.993988e-01 0.155 0 0
Maturation of nucleoprotein R-HSA-9694631 6.993988e-01 0.155 0 0
The NLRP3 inflammasome R-HSA-844456 6.993988e-01 0.155 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 7.014190e-01 0.154 0 0
Generation of second messenger molecules R-HSA-202433 7.014637e-01 0.154 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 7.034821e-01 0.153 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.037459e-01 0.153 0 0
Interleukin-21 signaling R-HSA-9020958 7.042129e-01 0.152 0 0
Gap junction degradation R-HSA-190873 7.042129e-01 0.152 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.042129e-01 0.152 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.042129e-01 0.152 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.042129e-01 0.152 0 0
mRNA Editing R-HSA-75072 7.042129e-01 0.152 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.042129e-01 0.152 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.042129e-01 0.152 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.042129e-01 0.152 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.042129e-01 0.152 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.042129e-01 0.152 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.042129e-01 0.152 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 7.042129e-01 0.152 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.068439e-01 0.151 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.133063e-01 0.147 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.164774e-01 0.145 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 7.167568e-01 0.145 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 7.167568e-01 0.145 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 7.167568e-01 0.145 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.204098e-01 0.142 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 7.240005e-01 0.140 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 7.240005e-01 0.140 0 0
Cargo concentration in the ER R-HSA-5694530 7.240005e-01 0.140 0 0
Signaling by PTK6 R-HSA-8848021 7.252290e-01 0.140 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 7.252290e-01 0.140 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 7.270960e-01 0.138 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.284244e-01 0.138 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.314647e-01 0.136 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 7.314647e-01 0.136 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.314647e-01 0.136 0 0
Signaling by FGFR1 in disease R-HSA-5655302 7.314647e-01 0.136 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 7.314647e-01 0.136 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.327754e-01 0.135 0 0
DNA replication initiation R-HSA-68952 7.327754e-01 0.135 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.327754e-01 0.135 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.327754e-01 0.135 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.327754e-01 0.135 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.327754e-01 0.135 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.327754e-01 0.135 0 0
Arachidonate production from DAG R-HSA-426048 7.327754e-01 0.135 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.327754e-01 0.135 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.327754e-01 0.135 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.327754e-01 0.135 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.327754e-01 0.135 0 0
Formation of apoptosome R-HSA-111458 7.327754e-01 0.135 0 0
Regulation of CDH11 function R-HSA-9762292 7.327754e-01 0.135 0 0
Signaling by Interleukins R-HSA-449147 7.340773e-01 0.134 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.400464e-01 0.131 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 7.401678e-01 0.131 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 7.401678e-01 0.131 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 7.401678e-01 0.131 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.401678e-01 0.131 0 0
Early Phase of HIV Life Cycle R-HSA-162594 7.401678e-01 0.131 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.403620e-01 0.131 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 7.403620e-01 0.131 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 7.455917e-01 0.127 0 0
Depyrimidination R-HSA-73928 7.455917e-01 0.127 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.470302e-01 0.127 0 0
Translation initiation complex formation R-HSA-72649 7.525743e-01 0.123 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 7.559430e-01 0.122 0 0
FGFR1 mutant receptor activation R-HSA-1839124 7.559430e-01 0.122 0 0
Recycling of bile acids and salts R-HSA-159418 7.559430e-01 0.122 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 7.585814e-01 0.120 0 0
Signaling by APC mutants R-HSA-4839744 7.585814e-01 0.120 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.585814e-01 0.120 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.585814e-01 0.120 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.585814e-01 0.120 0 0
vRNP Assembly R-HSA-192905 7.585814e-01 0.120 0 0
Synthesis of PI R-HSA-1483226 7.585814e-01 0.120 0 0
Bicarbonate transporters R-HSA-425381 7.585814e-01 0.120 0 0
Chylomicron assembly R-HSA-8963888 7.585814e-01 0.120 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.585814e-01 0.120 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 7.587188e-01 0.120 0 0
Defective pyroptosis R-HSA-9710421 7.591439e-01 0.120 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 7.591439e-01 0.120 0 0
Response of Mtb to phagocytosis R-HSA-9637690 7.591439e-01 0.120 0 0
HDACs deacetylate histones R-HSA-3214815 7.646295e-01 0.117 0 0
RNA Polymerase I Transcription R-HSA-73864 7.678935e-01 0.115 0 0
Acyl chain remodelling of PC R-HSA-1482788 7.707606e-01 0.113 0 0
Vpu mediated degradation of CD4 R-HSA-180534 7.707606e-01 0.113 0 0
Kidney development R-HSA-9830369 7.710570e-01 0.113 0 0
G1 Phase R-HSA-69236 7.721295e-01 0.112 0 0
Cyclin D associated events in G1 R-HSA-69231 7.721295e-01 0.112 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.721295e-01 0.112 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.758422e-01 0.110 0 0
FGFR2 alternative splicing R-HSA-6803529 7.761117e-01 0.110 0 0
mTORC1-mediated signalling R-HSA-166208 7.761117e-01 0.110 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.761117e-01 0.110 0 0
Signaling by FGFR1 R-HSA-5654736 7.762346e-01 0.110 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 7.762346e-01 0.110 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.818966e-01 0.107 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.818966e-01 0.107 0 0
Signaling by AXIN mutants R-HSA-4839735 7.818966e-01 0.107 0 0
Signaling by AMER1 mutants R-HSA-4839748 7.818966e-01 0.107 0 0
FMO oxidises nucleophiles R-HSA-217271 7.818966e-01 0.107 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.818966e-01 0.107 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.818966e-01 0.107 0 0
Anchoring fibril formation R-HSA-2214320 7.818966e-01 0.107 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.845580e-01 0.105 0 0
Base Excision Repair R-HSA-73884 7.847024e-01 0.105 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 7.848339e-01 0.105 0 0
Signal amplification R-HSA-392518 7.848339e-01 0.105 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.848339e-01 0.105 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.848339e-01 0.105 0 0
Mitophagy R-HSA-5205647 7.848339e-01 0.105 0 0
Interleukin-20 family signaling R-HSA-8854691 7.923970e-01 0.101 0 0
Carnitine shuttle R-HSA-200425 7.923970e-01 0.101 0 0
Growth hormone receptor signaling R-HSA-982772 7.923970e-01 0.101 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.981178e-01 0.098 0 0
Acyl chain remodelling of PE R-HSA-1482839 7.981841e-01 0.098 0 0
Regulation of Apoptosis R-HSA-169911 7.981841e-01 0.098 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 8.015027e-01 0.096 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.029614e-01 0.095 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 8.029614e-01 0.095 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 8.029614e-01 0.095 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.029614e-01 0.095 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.029614e-01 0.095 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.029614e-01 0.095 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.029614e-01 0.095 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.029614e-01 0.095 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.029614e-01 0.095 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.029614e-01 0.095 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.029614e-01 0.095 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.029614e-01 0.095 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.029614e-01 0.095 0 0
MET activates RAS signaling R-HSA-8851805 8.029614e-01 0.095 0 0
Mitochondrial RNA degradation R-HSA-9836573 8.076265e-01 0.093 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.076265e-01 0.093 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 8.076265e-01 0.093 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.077545e-01 0.093 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.077883e-01 0.093 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.108335e-01 0.091 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.108335e-01 0.091 0 0
FLT3 signaling in disease R-HSA-9682385 8.108335e-01 0.091 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 8.199927e-01 0.086 0 0
Tight junction interactions R-HSA-420029 8.218520e-01 0.085 0 0
Acyl chain remodelling of PS R-HSA-1482801 8.218520e-01 0.085 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.218520e-01 0.085 0 0
Formation of the nephric duct R-HSA-9830364 8.218520e-01 0.085 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.219928e-01 0.085 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.219928e-01 0.085 0 0
Chylomicron remodeling R-HSA-8963901 8.219928e-01 0.085 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.219928e-01 0.085 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.219928e-01 0.085 0 0
rRNA modification in the mitochondrion R-HSA-6793080 8.219928e-01 0.085 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.219928e-01 0.085 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.219928e-01 0.085 0 0
Interleukin-6 signaling R-HSA-1059683 8.219928e-01 0.085 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 8.228056e-01 0.085 0 0
Degradation of AXIN R-HSA-4641257 8.228056e-01 0.085 0 0
Cleavage of the damaged purine R-HSA-110331 8.228056e-01 0.085 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.277371e-01 0.082 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.281819e-01 0.082 0 0
Ca2+ pathway R-HSA-4086398 8.287130e-01 0.082 0 0
Oncogenic MAPK signaling R-HSA-6802957 8.309483e-01 0.080 0 0
MET promotes cell motility R-HSA-8875878 8.341245e-01 0.079 0 0
Depurination R-HSA-73927 8.341245e-01 0.079 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 8.341245e-01 0.079 0 0
Signaling by EGFR in Cancer R-HSA-1643713 8.351255e-01 0.078 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 8.351255e-01 0.078 0 0
TRP channels R-HSA-3295583 8.351255e-01 0.078 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 8.351255e-01 0.078 0 0
Suppression of phagosomal maturation R-HSA-9637687 8.351255e-01 0.078 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.356219e-01 0.078 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 8.367905e-01 0.077 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.387404e-01 0.076 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 8.387404e-01 0.076 0 0
PI3K Cascade R-HSA-109704 8.387609e-01 0.076 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.391871e-01 0.076 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 8.391871e-01 0.076 0 0
Glycerophospholipid catabolism R-HSA-6814848 8.391871e-01 0.076 0 0
HDL assembly R-HSA-8963896 8.391871e-01 0.076 0 0
Zinc transporters R-HSA-435354 8.391871e-01 0.076 0 0
Neddylation R-HSA-8951664 8.442010e-01 0.074 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.448150e-01 0.073 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.448150e-01 0.073 0 0
Interaction between L1 and Ankyrins R-HSA-445095 8.474980e-01 0.072 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 8.474980e-01 0.072 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 8.474980e-01 0.072 0 0
Insulin processing R-HSA-264876 8.474980e-01 0.072 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 8.474980e-01 0.072 0 0
Hedgehog ligand biogenesis R-HSA-5358346 8.481095e-01 0.072 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.482373e-01 0.071 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.514931e-01 0.070 0 0
IGF1R signaling cascade R-HSA-2428924 8.537265e-01 0.069 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.547214e-01 0.068 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.547214e-01 0.068 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.547214e-01 0.068 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 8.547214e-01 0.068 0 0
Other semaphorin interactions R-HSA-416700 8.547214e-01 0.068 0 0
p38MAPK events R-HSA-171007 8.547214e-01 0.068 0 0
Protein methylation R-HSA-8876725 8.547214e-01 0.068 0 0
Formation of the anterior neural plate R-HSA-9823739 8.547214e-01 0.068 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.549022e-01 0.068 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.549022e-01 0.068 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.590198e-01 0.066 0 0
Telomere Extension By Telomerase R-HSA-171319 8.590198e-01 0.066 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 8.590198e-01 0.066 0 0
Pyrimidine salvage R-HSA-73614 8.590198e-01 0.066 0 0
Pyroptosis R-HSA-5620971 8.590198e-01 0.066 0 0
Signaling by Hedgehog R-HSA-5358351 8.601723e-01 0.065 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.616304e-01 0.065 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 8.644113e-01 0.063 0 0
FLT3 Signaling R-HSA-9607240 8.644113e-01 0.063 0 0
ER-Phagosome pathway R-HSA-1236974 8.670780e-01 0.062 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 8.687560e-01 0.061 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.687560e-01 0.061 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.687560e-01 0.061 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.687560e-01 0.061 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.687560e-01 0.061 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.687560e-01 0.061 0 0
Attachment and Entry R-HSA-9678110 8.687560e-01 0.061 0 0
Signaling by Erythropoietin R-HSA-9006335 8.697396e-01 0.061 0 0
DNA methylation R-HSA-5334118 8.697396e-01 0.061 0 0
Late endosomal microautophagy R-HSA-9615710 8.697396e-01 0.061 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.733674e-01 0.059 0 0
MAP2K and MAPK activation R-HSA-5674135 8.733674e-01 0.059 0 0
Negative regulation of MAPK pathway R-HSA-5675221 8.733674e-01 0.059 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 8.734429e-01 0.059 0 0
Neurotransmitter release cycle R-HSA-112310 8.734856e-01 0.059 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 8.784162e-01 0.056 0 0
DAP12 signaling R-HSA-2424491 8.797049e-01 0.056 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 8.797049e-01 0.056 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.805071e-01 0.055 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.805071e-01 0.055 0 0
PKR-mediated signaling R-HSA-9833482 8.806353e-01 0.055 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.810360e-01 0.055 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.814355e-01 0.055 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 8.814355e-01 0.055 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.814355e-01 0.055 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.814355e-01 0.055 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.814355e-01 0.055 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 8.814355e-01 0.055 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.817954e-01 0.055 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.817954e-01 0.055 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 8.835165e-01 0.054 0 0
Interferon Signaling R-HSA-913531 8.844812e-01 0.053 0 0
Amyloid fiber formation R-HSA-977225 8.868464e-01 0.052 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 8.882299e-01 0.051 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.889613e-01 0.051 0 0
Downstream signal transduction R-HSA-186763 8.889613e-01 0.051 0 0
Signaling by FGFR4 R-HSA-5654743 8.897200e-01 0.051 0 0
Signaling by SCF-KIT R-HSA-1433557 8.897200e-01 0.051 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 8.928907e-01 0.049 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.928907e-01 0.049 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.928907e-01 0.049 0 0
Catecholamine biosynthesis R-HSA-209905 8.928907e-01 0.049 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.928907e-01 0.049 0 0
IRS-mediated signalling R-HSA-112399 8.950406e-01 0.048 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.951858e-01 0.048 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.958543e-01 0.048 0 0
DAP12 interactions R-HSA-2172127 8.971653e-01 0.047 0 0
Surfactant metabolism R-HSA-5683826 8.971653e-01 0.047 0 0
RMTs methylate histone arginines R-HSA-3214858 8.971653e-01 0.047 0 0
Proteasome assembly R-HSA-9907900 8.971653e-01 0.047 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.006425e-01 0.045 0 0
G1/S Transition R-HSA-69206 9.009989e-01 0.045 0 0
Ephrin signaling R-HSA-3928664 9.032398e-01 0.044 0 0
PKA activation in glucagon signalling R-HSA-164378 9.032398e-01 0.044 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.032398e-01 0.044 0 0
Apoptotic factor-mediated response R-HSA-111471 9.032398e-01 0.044 0 0
FGFR1 ligand binding and activation R-HSA-190242 9.032398e-01 0.044 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.032398e-01 0.044 0 0
PKA activation R-HSA-163615 9.032398e-01 0.044 0 0
Polo-like kinase mediated events R-HSA-156711 9.032398e-01 0.044 0 0
Tie2 Signaling R-HSA-210993 9.032398e-01 0.044 0 0
Nucleotide-like (purinergic) receptors R-HSA-418038 9.032398e-01 0.044 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.034269e-01 0.044 0 0
Signaling by FGFR3 R-HSA-5654741 9.041549e-01 0.044 0 0
DAG and IP3 signaling R-HSA-1489509 9.041549e-01 0.044 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.051828e-01 0.043 0 0
G-protein beta:gamma signalling R-HSA-397795 9.055214e-01 0.043 0 0
Vesicle-mediated transport R-HSA-5653656 9.055384e-01 0.043 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.075750e-01 0.042 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.107121e-01 0.041 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.107121e-01 0.041 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.107121e-01 0.041 0 0
Signaling by RAS mutants R-HSA-6802949 9.107121e-01 0.041 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.107121e-01 0.041 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.125894e-01 0.040 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 9.125894e-01 0.040 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.125894e-01 0.040 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 9.125894e-01 0.040 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.125894e-01 0.040 0 0
Other interleukin signaling R-HSA-449836 9.125894e-01 0.040 0 0
Diseases of hemostasis R-HSA-9671793 9.125894e-01 0.040 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.125894e-01 0.040 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.125894e-01 0.040 0 0
HDL remodeling R-HSA-8964058 9.125894e-01 0.040 0 0
Signaling by ERBB2 R-HSA-1227986 9.133295e-01 0.039 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.157715e-01 0.038 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 9.160439e-01 0.038 0 0
Recycling pathway of L1 R-HSA-437239 9.168592e-01 0.038 0 0
Signaling by FGFR in disease R-HSA-1226099 9.178494e-01 0.037 0 0
Signaling by ERBB4 R-HSA-1236394 9.178494e-01 0.037 0 0
Potential therapeutics for SARS R-HSA-9679191 9.181013e-01 0.037 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.187145e-01 0.037 0 0
Endogenous sterols R-HSA-211976 9.187622e-01 0.037 0 0
RAF activation R-HSA-5673000 9.197485e-01 0.036 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 9.197485e-01 0.036 0 0
Hyaluronan metabolism R-HSA-2142845 9.197485e-01 0.036 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 9.210362e-01 0.036 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.210362e-01 0.036 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 9.210362e-01 0.036 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.210362e-01 0.036 0 0
Protein hydroxylation R-HSA-9629569 9.210362e-01 0.036 0 0
Signal transduction by L1 R-HSA-445144 9.210362e-01 0.036 0 0
Melanin biosynthesis R-HSA-5662702 9.210362e-01 0.036 0 0
Chaperonin-mediated protein folding R-HSA-390466 9.230790e-01 0.035 0 0
Signaling by PDGF R-HSA-186797 9.238879e-01 0.034 0 0
Signaling by FGFR R-HSA-190236 9.245201e-01 0.034 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.260814e-01 0.033 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.280092e-01 0.032 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.286672e-01 0.032 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.286672e-01 0.032 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.286672e-01 0.032 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.286672e-01 0.032 0 0
Signalling to RAS R-HSA-167044 9.286672e-01 0.032 0 0
Basigin interactions R-HSA-210991 9.286672e-01 0.032 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 9.319403e-01 0.031 0 0
RNA Polymerase III Transcription R-HSA-74158 9.319403e-01 0.031 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.319403e-01 0.031 0 0
Calmodulin induced events R-HSA-111933 9.319403e-01 0.031 0 0
CaM pathway R-HSA-111997 9.319403e-01 0.031 0 0
Insulin receptor signalling cascade R-HSA-74751 9.332751e-01 0.030 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.355611e-01 0.029 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.355611e-01 0.029 0 0
Assembly Of The HIV Virion R-HSA-175474 9.355611e-01 0.029 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.355611e-01 0.029 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.355611e-01 0.029 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.355611e-01 0.029 0 0
Attachment and Entry R-HSA-9694614 9.355611e-01 0.029 0 0
Voltage gated Potassium channels R-HSA-1296072 9.373576e-01 0.028 0 0
Collagen chain trimerization R-HSA-8948216 9.373576e-01 0.028 0 0
Metabolism of folate and pterines R-HSA-196757 9.373576e-01 0.028 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.403297e-01 0.027 0 0
Viral Infection Pathways R-HSA-9824446 9.403433e-01 0.027 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 9.417891e-01 0.026 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.417891e-01 0.026 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.417891e-01 0.026 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.417891e-01 0.026 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.417891e-01 0.026 0 0
LDL clearance R-HSA-8964038 9.417891e-01 0.026 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.417891e-01 0.026 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.421775e-01 0.026 1 1
Orc1 removal from chromatin R-HSA-68949 9.421775e-01 0.026 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.421775e-01 0.026 0 0
Purine salvage R-HSA-74217 9.423640e-01 0.026 0 0
Cellular response to starvation R-HSA-9711097 9.425308e-01 0.026 0 0
Signaling by FGFR2 R-HSA-5654738 9.430839e-01 0.025 0 0
Signaling by VEGF R-HSA-194138 9.446966e-01 0.025 0 0
Protein folding R-HSA-391251 9.455905e-01 0.024 0 0
Smooth Muscle Contraction R-HSA-445355 9.462940e-01 0.024 0 0
Plasma lipoprotein clearance R-HSA-8964043 9.469882e-01 0.024 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.469882e-01 0.024 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.474155e-01 0.023 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.474155e-01 0.023 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.474155e-01 0.023 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 9.474155e-01 0.023 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.474155e-01 0.023 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.501365e-01 0.022 0 0
Interleukin-2 family signaling R-HSA-451927 9.512574e-01 0.022 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.513520e-01 0.022 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.516628e-01 0.022 0 0
L1CAM interactions R-HSA-373760 9.517671e-01 0.021 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.524984e-01 0.021 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.524984e-01 0.021 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.524984e-01 0.021 0 0
Interleukin-6 family signaling R-HSA-6783589 9.524984e-01 0.021 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.551969e-01 0.020 0 0
Maturation of spike protein R-HSA-9694548 9.551969e-01 0.020 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.554741e-01 0.020 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.570903e-01 0.019 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.570903e-01 0.019 0 0
Laminin interactions R-HSA-3000157 9.570903e-01 0.019 0 0
Hyaluronan degradation R-HSA-2160916 9.570903e-01 0.019 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.570903e-01 0.019 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.570903e-01 0.019 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 9.570903e-01 0.019 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.572645e-01 0.019 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 9.575829e-01 0.019 0 0
Translation of Structural Proteins R-HSA-9683701 9.588305e-01 0.018 0 0
Stimuli-sensing channels R-HSA-2672351 9.590203e-01 0.018 0 0
Synthesis of PA R-HSA-1483166 9.601793e-01 0.018 0 0
Attachment of bacteria to epithelial cells R-HSA-9638630 9.612385e-01 0.017 0 0
Sphingolipid catabolism R-HSA-9845614 9.612385e-01 0.017 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.612385e-01 0.017 0 0
Cilium Assembly R-HSA-5617833 9.613189e-01 0.017 0 0
Ca-dependent events R-HSA-111996 9.621806e-01 0.017 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.649859e-01 0.015 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.649859e-01 0.015 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.649859e-01 0.015 0 0
EPHB-mediated forward signaling R-HSA-3928662 9.681122e-01 0.014 0 0
Amine ligand-binding receptors R-HSA-375280 9.681122e-01 0.014 0 0
Metabolism of polyamines R-HSA-351202 9.682981e-01 0.014 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.683712e-01 0.014 0 0
Insulin receptor recycling R-HSA-77387 9.683712e-01 0.014 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.683712e-01 0.014 0 0
Nucleotide salvage R-HSA-8956321 9.706374e-01 0.013 0 0
Collagen degradation R-HSA-1442490 9.706374e-01 0.013 0 0
PLC beta mediated events R-HSA-112043 9.706374e-01 0.013 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.707313e-01 0.013 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.714294e-01 0.013 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.714294e-01 0.013 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.714294e-01 0.013 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 9.714294e-01 0.013 0 0
PI Metabolism R-HSA-1483255 9.720886e-01 0.012 0 0
Translation of Structural Proteins R-HSA-9694635 9.726780e-01 0.012 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.728126e-01 0.012 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.731423e-01 0.012 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.731423e-01 0.012 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.731423e-01 0.012 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.741921e-01 0.011 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.741921e-01 0.011 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 9.741921e-01 0.011 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.741921e-01 0.011 0 0
Neurotransmitter clearance R-HSA-112311 9.741921e-01 0.011 0 0
ABC transporter disorders R-HSA-5619084 9.745528e-01 0.011 0 0
Synthesis of PC R-HSA-1483191 9.753609e-01 0.011 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.754336e-01 0.011 0 0
Interferon alpha/beta signaling R-HSA-909733 9.758513e-01 0.011 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.758513e-01 0.011 0 0
Budding and maturation of HIV virion R-HSA-162588 9.766877e-01 0.010 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.766877e-01 0.010 0 0
Signaling by Insulin receptor R-HSA-74752 9.770235e-01 0.010 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.770235e-01 0.010 0 0
Co-stimulation by CD28 R-HSA-389356 9.774017e-01 0.010 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.774017e-01 0.010 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.779457e-01 0.010 0 0
Peptide hormone metabolism R-HSA-2980736 9.785983e-01 0.009 0 0
Gap junction trafficking and regulation R-HSA-157858 9.792784e-01 0.009 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.800768e-01 0.009 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.809788e-01 0.008 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.809788e-01 0.008 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 9.809788e-01 0.008 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.810036e-01 0.008 0 0
G-protein mediated events R-HSA-112040 9.815797e-01 0.008 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.815797e-01 0.008 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.828185e-01 0.008 0 0
Heme degradation R-HSA-189483 9.828185e-01 0.008 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.828185e-01 0.008 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 9.844803e-01 0.007 0 0
eNOS activation R-HSA-203615 9.844803e-01 0.007 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.844803e-01 0.007 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.844803e-01 0.007 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.852003e-01 0.006 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.853835e-01 0.006 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.859816e-01 0.006 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.862023e-01 0.006 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.865758e-01 0.006 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.867358e-01 0.006 0 0
Muscle contraction R-HSA-397014 9.870679e-01 0.006 0 0
G1/S-Specific Transcription R-HSA-69205 9.873377e-01 0.006 0 0
Triglyceride catabolism R-HSA-163560 9.873377e-01 0.006 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.873377e-01 0.006 0 0
Ribosome-associated quality control R-HSA-9948299 9.885317e-01 0.005 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.885626e-01 0.005 0 0
Ubiquinol biosynthesis R-HSA-2142789 9.885626e-01 0.005 0 0
NCAM1 interactions R-HSA-419037 9.885626e-01 0.005 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.885626e-01 0.005 0 0
Ion homeostasis R-HSA-5578775 9.887743e-01 0.005 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.894396e-01 0.005 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.896692e-01 0.005 0 0
Elastic fibre formation R-HSA-1566948 9.896692e-01 0.005 0 0
Biofilm formation R-HSA-9931953 9.896692e-01 0.005 0 0
Protein ubiquitination R-HSA-8852135 9.902560e-01 0.004 1 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.902560e-01 0.004 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.906687e-01 0.004 0 0
Pentose phosphate pathway R-HSA-71336 9.906687e-01 0.004 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.906687e-01 0.004 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.915716e-01 0.004 0 0
Glycogen metabolism R-HSA-8982491 9.915716e-01 0.004 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.921255e-01 0.003 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.921493e-01 0.003 0 0
Integrin cell surface interactions R-HSA-216083 9.923561e-01 0.003 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.931239e-01 0.003 0 0
Collagen formation R-HSA-1474290 9.932534e-01 0.003 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.934116e-01 0.003 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.934126e-01 0.003 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.934269e-01 0.003 0 0
Activation of GABAB receptors R-HSA-991365 9.937893e-01 0.003 0 0
GABA B receptor activation R-HSA-977444 9.937893e-01 0.003 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.937893e-01 0.003 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.937893e-01 0.003 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.939751e-01 0.003 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.942076e-01 0.003 0 0
Pyrimidine catabolism R-HSA-73621 9.943904e-01 0.002 0 0
Formation of the cornified envelope R-HSA-6809371 9.946221e-01 0.002 0 0
Gap junction trafficking R-HSA-190828 9.949333e-01 0.002 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.949333e-01 0.002 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.953994e-01 0.002 0 0
Neuronal System R-HSA-112316 9.954212e-01 0.002 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.954237e-01 0.002 0 0
Neutrophil degranulation R-HSA-6798695 9.956053e-01 0.002 0 0
Transmission across Chemical Synapses R-HSA-112315 9.956337e-01 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.957412e-01 0.002 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.958667e-01 0.002 0 0
Platelet degranulation R-HSA-114608 9.959251e-01 0.002 0 0
ABC-family proteins mediated transport R-HSA-382556 9.960585e-01 0.002 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.961560e-01 0.002 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.962038e-01 0.002 0 0
Intraflagellar transport R-HSA-5620924 9.966282e-01 0.001 0 0
GPER1 signaling R-HSA-9634597 9.966282e-01 0.001 0 0
Metal ion SLC transporters R-HSA-425410 9.966282e-01 0.001 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.966642e-01 0.001 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.968285e-01 0.001 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.968285e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.970695e-01 0.001 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.970695e-01 0.001 0 0
Cardiac conduction R-HSA-5576891 9.971329e-01 0.001 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.973682e-01 0.001 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.975125e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.975159e-01 0.001 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.975159e-01 0.001 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.975965e-01 0.001 0 0
Platelet homeostasis R-HSA-418346 9.977201e-01 0.001 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.977686e-01 0.001 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.978932e-01 0.001 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.980535e-01 0.001 0 0
Integration of energy metabolism R-HSA-163685 9.981318e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.981328e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.982841e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.983393e-01 0.001 0 0
G alpha (z) signalling events R-HSA-418597 9.983472e-01 0.001 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.984234e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.984512e-01 0.001 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.985072e-01 0.001 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.985072e-01 0.001 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.985516e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.986518e-01 0.001 0 0
Potassium Channels R-HSA-1296071 9.986696e-01 0.001 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.987824e-01 0.001 0 0
Regulation of insulin secretion R-HSA-422356 9.988780e-01 0.000 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.988868e-01 0.000 0 0
Peroxisomal protein import R-HSA-9033241 9.989004e-01 0.000 0 0
Triglyceride metabolism R-HSA-8979227 9.989004e-01 0.000 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.989004e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.990069e-01 0.000 0 0
RAB geranylgeranylation R-HSA-8873719 9.990069e-01 0.000 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.990069e-01 0.000 0 0
tRNA Aminoacylation R-HSA-379724 9.990069e-01 0.000 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.990224e-01 0.000 0 0
Aquaporin-mediated transport R-HSA-445717 9.991031e-01 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 9.991319e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.991866e-01 0.000 0 0
Mitochondrial protein import R-HSA-1268020 9.991900e-01 0.000 0 0
Opioid Signalling R-HSA-111885 9.993292e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.993394e-01 0.000 0 0
Ion transport by P-type ATPases R-HSA-936837 9.993394e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.993394e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.994178e-01 0.000 0 0
Peptide chain elongation R-HSA-156902 9.994377e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.994449e-01 0.000 1 0
Nicotinate metabolism R-HSA-196807 9.995134e-01 0.000 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.995134e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.995606e-01 0.000 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.995964e-01 0.000 0 0
Parasite infection R-HSA-9664407 9.995964e-01 0.000 0 0
Leishmania phagocytosis R-HSA-9664417 9.995964e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.995967e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996194e-01 0.000 0 0
rRNA processing R-HSA-72312 9.996205e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.996442e-01 0.000 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.996466e-01 0.000 0 0
Ion channel transport R-HSA-983712 9.996557e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.996764e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.996764e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.996764e-01 0.000 0 0
Interferon gamma signaling R-HSA-877300 9.996837e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.997293e-01 0.000 0 0
Eukaryotic Translation Termination R-HSA-72764 9.997567e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.997784e-01 0.000 0 0
Cholesterol biosynthesis R-HSA-191273 9.998415e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.998569e-01 0.000 0 0
Hemostasis R-HSA-109582 9.998677e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998833e-01 0.000 0 0
Viral mRNA Translation R-HSA-192823 9.998851e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.998928e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.998928e-01 0.000 0 0
Immune System R-HSA-168256 9.999116e-01 0.000 1 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999367e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.999429e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.999484e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999508e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999580e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999721e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999722e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999761e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999761e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999794e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999799e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999855e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999858e-01 0.000 1 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.999915e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999934e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999940e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999940e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999940e-01 0.000 0 0
Protein localization R-HSA-9609507 9.999954e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999963e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999976e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999977e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999983e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999983e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999988e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999990e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999993e-01 0.000 0 0
Disease R-HSA-1643685 9.999995e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999996e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999996e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999998e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999999e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Translation R-HSA-72766 1.000000e+00 0.000 0 0
Sphingolipid metabolism R-HSA-428157 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Metabolism of nucleotides R-HSA-15869 1.000000e+00 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 1 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
G alpha (i) signalling events R-HSA-418594 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways