CK1G3

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00443 S619 Sugiyama PIK3C2A SVKKLKRAVNLPRSKtADVTsLFGGEDTSRSSTRGSLNPEN
O14980 S450 Sugiyama XPO1 CRM1 VLVVENDQGEVVREFMKDTDsINLyKNMRETLVyLTHLDyV
O43707 T445 Sugiyama ACTN4 HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O43719 S702 Sugiyama HTATSF1 EDADGKEVEDADEKLFEDDDsNEKLFDEEEDssEKLFDDsD
O43815 S229 Sugiyama STRN TEAEVKETAMIAKSELtDsAsVLDNFKFLEsAAADFsDEDE
O43815 S301 Sugiyama STRN TKEALKEFDFLVTSEEGDNEsRSAGDGTDWEKEDQCLMPEA
O43823 S685 Sugiyama AKAP8 AKAP95 TRVAPAPAAADAEVEQtDAEsKDAVPTE_____________
O43852 S261 Sugiyama CALU RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O43852 Y263 Sugiyama CALU KNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNKDG
O43852 Y47 Sugiyama CALU RVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQLtPE
O60231 S112 Sugiyama DHX16 DBP2 DDX16 KIAA0577 PRP2 EKNRSYRLLEDsEEssEEtVsRAGsSLQKKRKKRKHLRKKR
O60664 S225 Sugiyama PLIN3 M6PRBP1 TIP47 PLTDAELARIAtsLDGFDVAsVQQQRQEQSyFVRLGsLSER
O60701 S392 Sugiyama UGDH PREQIVVDLsHPGVSEDDQVsRLVTISKDPYEACDGAHAVV
O60841 S186 Sugiyama EIF5B IF2 KIAA0741 EDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKN
O60841 S222 Sugiyama EIF5B IF2 KIAA0741 KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK
O60841 S66 Sugiyama EIF5B IF2 KIAA0741 KEKKKQDFDEDDILKELEELsLEAQGIKADREtVAVKPTEN
O75581 S1490 PSP LRP6 SSSSssTKGtYFPAILNPPPsPAtERsHYTMEFGYSsNsPs
O75581 T1479 SIGNOR|PSP LRP6 PYDRAHVTGASSSSSssTKGtYFPAILNPPPsPAtERsHYT
O75581 T1493 SIGNOR LRP6 SssTKGtYFPAILNPPPsPAtERsHYTMEFGYSsNsPsTHR
O95218 S153 Sugiyama ZRANB2 ZIS ZNF265 KYRGKAVGPAsILKEVEDKEsEGEEEDEDEDLsKyKLDEDE
P04075 S132 Sugiyama ALDOA ALDA GVVPLAGtNGEtttQGLDGLsERCAQYKKDGADFAKWRCVL
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T125 Sugiyama ALDOA ALDA VGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYKKDGADF
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075 T49 Sugiyama ALDOA ALDA GILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtADDR
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05023 S217 Sugiyama ATP1A1 DRIPADLRIIsANGCKVDNssLtGESEPQtRsPDFtNENPL
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P06733 Y270 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P06733 Y280 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 DFKsPDDPsRyIsPDQLADLyKsFIKDyPVVsIEDPFDQDD
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814 S739 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07814 S825 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PAEIGQNIssNssAsILESKsLyDEVAAQGEVVRKLKAEKS
P07900 S476 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA RKKLsELLRyytsAsGDEMVsLKDYCTRMKENQKHIyyItG
P07948 S13 SIGNOR|PSP LYN JTK8 ________MGCIKSKGKDsLsDDGVDLKTQPVRNTERTIyV
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 T297 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08670 S214 Sugiyama VIM LQREEAENtLQsFRQDVDNAsLARLDLERKVEsLQEEIAFL
P08708 S89 Sugiyama RPS17 RPS17L ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09972 S132 Sugiyama ALDOC ALDC GVVPLAGtDGEtttQGLDGLsERCAQYKKDGADFAKWRCVL
P09972 T125 Sugiyama ALDOC ALDC VGIKVDKGVVPLAGtDGEtttQGLDGLsERCAQYKKDGADF
P0CG47 T55 Sugiyama UBB GIPPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRG
P0CG48 T55 Sugiyama UBC GIPPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRG
P11047 T943 Sugiyama LAMC1 LAMB2 FYNLQSGQGCERCDCHALGstNGQCDIRTGQCECQPGITGQ
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P13010 S318 Sugiyama XRCC5 G22P2 NDDDETEVLKEDIIQGFRyGsDIVPFSKVDEEQMKYKSEGK
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13637 S207 Sugiyama ATP1A3 DRVPADLRIISAHGCKVDNssLtGESEPQTRSPDCTHDNPL
P13667 T449 Sugiyama PDIA4 ERP70 ERP72 AATQFWRSKVLEVAKDFPEytFAIADEEDyAGEVKDLGLsE
P13667 Y458 Sugiyama PDIA4 ERP70 ERP72 VLEVAKDFPEytFAIADEEDyAGEVKDLGLsEsGEDVNAAI
P14314 S126 Sugiyama PRKCSH G19P1 yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618 S205 Sugiyama PKM OIP3 PK2 PK3 PKM2 VKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVsEKD
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S523 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 RtRLAKLLRFQssHHPtDItsLDQyVERMKEKQDKIyFMAG
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P19338 S458 Sugiyama NCL TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 Y462 Sugiyama NCL AEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWs
P20042 S158 Sugiyama EIF2S2 EIF2B EILEKDEALEDEDNKKDDGIsFsNQtGPAWAGSERDytyEE
P20648 S228 Sugiyama ATP4A DRVPADIRILAAQGCKVDNssLtGESEPQTRSPECTHESPL
P22314 S46 Sugiyama UBA1 A1S9T UBE1 AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P23396 S35 Sugiyama RPS3 OK/SW-cl.26 GIFKAELNEFLtRELAEDGysGVEVRVtPTRTEIIILATRT
P25705 S53 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM ARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETGR
P25788 S243 Sugiyama PSMA3 HC8 PSC8 GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________
P25788 Y239 Sugiyama PSMA3 HC8 PSC8 ELTNGRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM____
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692 S60 Sugiyama EEF1D EF1D ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P29692 S64 Sugiyama EEF1D EF1D sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30101 S474 Sugiyama PDIA3 ERP57 ERP60 GRP58 yFsPANKKLNPKKyEGGRELsDFIsyLQREAtNPPVIQEEK
P30101 S478 Sugiyama PDIA3 ERP57 ERP60 GRP58 ANKKLNPKKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKK
P31327 S1021 Sugiyama CPS1 RTLRQLGKKTVVVNCNPETVstDFDECDKLyFEELSLERIL
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P38646 S212 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 tVPAyFNDsQRQAtKDAGQIsGLNVLRVINEPTAAALAyGL
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P40925 S326 Sugiyama MDH1 MDHA NDFSREKMDLTAKELtEEKEsAFEFLssA____________
P40925 S332 Sugiyama MDH1 MDHA KMDLTAKELtEEKEsAFEFLssA__________________
P47712 S729 Sugiyama PLA2G4A CPLA2 PLA2G4 KEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKPKA
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P49368 T486 Sugiyama CCT3 CCTG TRIC5 LRAKHtQENCEtWGVNGEtGtLVDMKELGIWEPLAVKLQTY
P50993 S215 Sugiyama ATP1A2 KIAA0778 DRVPADLRIISSHGCKVDNssLtGESEPQTRSPEFTHENPL
P51116 S601 Sugiyama FXR2 FMR1L2 RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P53999 S17 Sugiyama SUB1 PC4 RPO2TC1 ____MPKSKELVsssssGsDsDsEVDKKLKRKKQVAPEKPV
P53999 S19 Sugiyama SUB1 PC4 RPO2TC1 __MPKSKELVsssssGsDsDsEVDKKLKRKKQVAPEKPVKK
P54577 S386 Sugiyama YARS1 YARS sRLDIRVGKIITVEKHPDADsLyVEKIDVGEAEPRTVVSGL
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P60174 S212 Sugiyama TPI1 TPI WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 S60 Sugiyama ACTB HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61916 S29 Sugiyama NPC2 HE1 LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 S62 Sugiyama ACTA2 ACTSA ACTVS GIG46 HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62857 T57 Sugiyama RPS28 DtsRsIIRNVKGPVREGDVLtLLEsEREARRLR________
P62979 T55 Sugiyama RPS27A UBA80 UBCEP1 GIPPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRG
P62987 T55 Sugiyama UBA52 UBCEP2 GIPPDQQRLIFAGKQLEDGRtLsDyNIQKEstLHLVLRLRG
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63151 S409 Sugiyama PPP2R2A RTVLKPRKVCASGKRKKDEIsVDsLDFNKKILHTAWHPKEN
P63151 S412 Sugiyama PPP2R2A LKPRKVCASGKRKKDEIsVDsLDFNKKILHTAWHPKENIIA
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 S60 Sugiyama ACTG1 ACTG HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 S61 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 S62 Sugiyama ACTC1 ACTC HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 S62 Sugiyama ACTA1 ACTA HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q00610 S1494 Sugiyama CLTC CLH17 CLTCL2 KIAA0034 EEDyQALRTsIDAyDNFDNIsLAQRLEKHELIEFRRIAAYL
Q01105 S133 Sugiyama SET DEEALHYLTRVEVtEFEDIKsGyRIDFyFDENPyFENKVLS
Q01105 S165 Sugiyama SET PyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQ
Q01105 S166 Sugiyama SET yFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQT
Q01105 S168 Sugiyama SET ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q02952 S1256 Sugiyama AKAP12 AKAP250 QSKMEDtLEHTDKEVsVEtVsILsKTEGtQEADQyADEKTK
Q02952 S1259 Sugiyama AKAP12 AKAP250 MEDtLEHTDKEVsVEtVsILsKTEGtQEADQyADEKTKDVP
Q04760 S114 Sugiyama GLO1 SRKATLELTHNWGtEDDEtQsyHNGNsDPRGFGHIGIAVPD
Q07021 S205 Sugiyama C1QBP GC1QBP HABP1 SF2P32 DCHyPEDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYT
Q07157 S1065 Sugiyama TJP1 ZO1 YVEKQAsRDLEQPtyRyEsssytDQFsRNYEHRLRYEDRVP
Q12888 S301 Sugiyama TP53BP1 AQELMEsGLQIQKsPEPEVLstQEDLFDQsNKtVssDGCst
Q12906 S190 Sugiyama ILF3 DRBF MPHOSPH4 NF90 HLTSPVVREEMEKVLAGEtLsVNDPPDVLDRQKCLAALASL
Q12906 T188 Sugiyama ILF3 DRBF MPHOSPH4 NF90 TIHLTSPVVREEMEKVLAGEtLsVNDPPDVLDRQKCLAALA
Q13263 S784 Sugiyama TRIM28 KAP1 RNF96 TIF1B DVGRMFKQFNKLTEDKADVQsIIGLQRFFETRMNEAFGDTK
Q13435 S317 Sugiyama SF3B2 SAP145 ETDARssLGQsAsEtEEDtVsVsKKEKNRKRRNRKKKKKPQ
Q13541 S112 Sugiyama EIF4EBP1 EAsQsHLRNsPEDKRAGGEEsQFEMDI______________
Q14151 S194 Sugiyama SAFB2 KIAA0138 PAQPPEHAVDGEGFKNtLEtssLNFKVtPDIEEsLLEPENE
Q14152 S1028 Sugiyama EIF3A EIF3S10 KIAA0139 NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152 S988 Sugiyama EIF3A EIF3S10 KIAA0139 PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14566 S268 Sugiyama MCM6 LIVVPDVSKLSTPGARAEtNsRVsGVDGyEtEGIRGLRALG
Q14566 S271 Sugiyama MCM6 VPDVSKLSTPGARAEtNsRVsGVDGyEtEGIRGLRALGVRD
Q14978 S637 Sugiyama NOLC1 KIAA0035 NS5ATP13 GEKRAssPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGER
Q15080 S67 Sugiyama NCF4 SH3PXD4 TKGGSKYLIYRRYRQFHALQsKLEERFGPDSKSSALACTLP
Q15293 S69 Sugiyama RCN1 RCN PPEDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVD
Q53EL6 S78 Sugiyama PDCD4 H731 KAKRRLRKNssRDsGRGDsVsDsGsDALRSGLtVPtsPKGR
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q5JSH3 S199 Sugiyama WDR44 RPH11 EAVEVKGGGDVLEPVssDsLstKDFAAVEEVAPAKPPRHLt
Q5UIP0 S1693 Sugiyama RIF1 NLRTRNAIKRLHKRDsFDNCsLGESSKIGIsDIssLsEKtF
Q66LE6 S415 Sugiyama PPP2R2D KIAA1541 RASLKPRKVCTGGKRRKDEIsVDsLDFNKKILHTAWHPVDN
Q66LE6 S418 Sugiyama PPP2R2D KIAA1541 LKPRKVCTGGKRRKDEIsVDsLDFNKKILHTAWHPVDNVIA
Q6P2E9 S887 Sugiyama EDC4 HEDLS QQRDsQDAsAEQsDHDDEVAsLAsAsGGFGTKVPAPRLPAK
Q6P2E9 S890 Sugiyama EDC4 HEDLS DsQDAsAEQsDHDDEVAsLAsAsGGFGTKVPAPRLPAKDWK
Q6P996 S722 Sugiyama PDXDC1 KIAA0251 PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI
Q6PKG0 S631 Sugiyama LARP1 KIAA0731 LARP EEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVtQtPH
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6UXH1 S295 Sugiyama CRELD2 UNQ185/PRO211 KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q8IWS0 S181 Sugiyama PHF6 CENP-31 KIAA1823 KSRKGRPRKTNFKGLSEDtRstssHGtDEMEsssyRDRsPH
Q8IWS0 T179 Sugiyama PHF6 CENP-31 KIAA1823 KKKSRKGRPRKTNFKGLSEDtRstssHGtDEMEsssyRDRs
Q8NBJ7 S283 Sugiyama SUMF2 PSEC0171 UNQ1968/PRO4500 GsANHRARVttRMGNtPDsAsDNLGFRCAADAGRPPGEL__
Q8NBS9 S129 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 MEDAKVYVAKVDCtAHsDVCsAQGVRGYPTLKLFKPGQEAV
Q8ND56 S374 Sugiyama LSM14A C19orf13 FAM61A RAP55 RAP55A EDPLGPNCYYDKTKsFFDNIsCDDNRERRPtWAEERRLNAE
Q8WU90 S231 Sugiyama ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730 LPPGFVLKKDKKKEEKEDEIsLEDLIERERSALGPNVTKIT
Q8WU90 S351 Sugiyama ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730 DIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLsEAs
Q8WU90 T348 Sugiyama ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730 sVNDIDLSLYIPRDVDEtGItVAsLERFSTYTsDKDENKLs
Q92785 S142 Sugiyama DPF2 BAF45D REQ UBID4 LLRTDPLEKRGAPDPRVDDDsLGEFPVTNsRARKRILEPDD
Q92974 S976 Sugiyama ARHGEF2 KIAA0651 LFP40 sPPHsPRDFtRMQDIPEEtEsRDGEAVASES__________
Q96T58 S96 Sugiyama SPEN KIAA0929 MINT SHARP TDYNEPGTIPSAARGLDDTVsIAsRSREVSGFRGGGGGPAy
Q96T58 S99 Sugiyama SPEN KIAA0929 MINT SHARP NEPGTIPSAARGLDDTVsIAsRSREVSGFRGGGGGPAyGPP
Q99622 S97 Sugiyama C12orf57 C10 GVLKFARLVKSYEAQDPEIAsLSGKLKALFLPPMTLPPHGP
Q99733 S125 Sugiyama NAP1L4 NAP2 KRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKVVVTE
Q99848 S270 Sugiyama EBNA1BP2 EBP2 FGGKKKGSKWNtREsyDDVssFRAKTAHGRGLKRPGKKGSN
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3 Y432 Sugiyama TUBA1C TUBA6 GMEEGEFSEAREDMAALEKDyEEVGADsADGEDEGEEy___
Q9BTC0 S352 Sugiyama DIDO1 C20orf158 DATF1 KIAA0333 TADQQEAKWRPGDADGTDCTsIGtIEQKSSEDQGIKGRIEK
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9GZT8 S193 Sugiyama NIF3L1 ALS2CR1 MDS015 My018 VNytQDLDKVMSAVKGIDGVsVTsFSARTGNEEQTRINLNC
Q9GZT8 S196 Sugiyama NIF3L1 ALS2CR1 MDS015 My018 tQDLDKVMSAVKGIDGVsVTsFSARTGNEEQTRINLNCTQK
Q9H1E3 S132 Sugiyama NUCKS1 NUCKS JC7 GsEEEQEEEDEAPFQEKDsGsDEDFLMEDDDDsDyGSsKKK
Q9H2G2 S446 Sugiyama SLK KIAA0204 STK2 KRPKLENLPDTEDQEtVDINsVsEGKENNIMITLETNIEHN
Q9H501 S77 Sugiyama ESF1 ABTAP C20orf6 HDCMC28P GRPISHSTTEDLKRFyDLsDsDsNLsGEDSKALSQKKIKKK
Q9H501 S79 Sugiyama ESF1 ABTAP C20orf6 HDCMC28P PISHSTTEDLKRFyDLsDsDsNLsGEDSKALSQKKIKKKKT
Q9H501 S82 Sugiyama ESF1 ABTAP C20orf6 HDCMC28P HSTTEDLKRFyDLsDsDsNLsGEDSKALSQKKIKKKKTQTK
Q9NR30 S466 Sugiyama DDX21 ETKKEAQELSQNsAIKQDAQsLHGDIPQKQREITLKGFRNG
Q9P2E9 S1122 Sugiyama RRBP1 KIAA1398 APAEPSSDLASKLREAEEtQstLQAECDQYRSILAETEGML
Q9UHR5 S52 Sugiyama SAP30BP HCNGP HTRG HTRP GSAAEEKGGLVsDAyGEDDFsRLGGDEDGYEEEEDENsRQS
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y446 S180 Sugiyama PKP3 RPVsFHERGGVGsRADyDtLsLRsLRLGPGGLDDRysLVsE
Q9Y446 S183 Sugiyama PKP3 sFHERGGVGsRADyDtLsLRsLRLGPGGLDDRysLVsEQLE
Q9Y696 S31 Sugiyama CLIC4 KEEDKEPLIELFVKAGsDGEsIGNCPFSQRLFMILWLKGVV
Q9Y6I9 S259 Sugiyama TEX264 ZSIG11 UNQ337/PRO536 sAAtLsPGASsRGWDDGDtRsEHSYsESGAsGssFEELDLE
Q9Y6I9 T257 Sugiyama TEX264 ZSIG11 UNQ337/PRO536 EtsAAtLsPGASsRGWDDGDtRsEHSYsESGAsGssFEELD
Q9Y6M4 S31 Sugiyama CSNK1G3 SDDRMARPSGRSGHNTRGtGssssGVLMVGPNFRVGKKIGC
Q9Y6M4 S32 Sugiyama CSNK1G3 DDRMARPSGRSGHNTRGtGssssGVLMVGPNFRVGKKIGCG
Q9Y6M4 S33 Sugiyama CSNK1G3 DRMARPSGRSGHNTRGtGssssGVLMVGPNFRVGKKIGCGN
Q9Y6M4 S34 Sugiyama CSNK1G3 RMARPSGRSGHNTRGtGssssGVLMVGPNFRVGKKIGCGNF
Q9Y6M4 S344 Sugiyama CSNK1G3 DWIGKQLPtPVGAVQQDPALssNREAHQHRDKMQQSKNQSA
Q9Y6M4 S345 Sugiyama CSNK1G3 WIGKQLPtPVGAVQQDPALssNREAHQHRDKMQQSKNQSAD
Q9Y6M4 S372 Sugiyama CSNK1G3 HRDKMQQSKNQSADHRAAWDsQQANPHHLRAHLAADRHGGS
Q9Y6M4 T29 Sugiyama CSNK1G3 DKSDDRMARPSGRSGHNTRGtGssssGVLMVGPNFRVGKKI
Q9Y6M4 T332 Sugiyama CSNK1G3 FDRKGYMFDyEyDWIGKQLPtPVGAVQQDPALssNREAHQH
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 3.170635e-09 8.499 0 0
Mitotic Prometaphase R-HSA-68877 1.246701e-08 7.904 0 0
Cell Cycle, Mitotic R-HSA-69278 3.442138e-08 7.463 0 0
M Phase R-HSA-68886 7.220140e-08 7.141 0 0
Signal Transduction R-HSA-162582 1.500339e-07 6.824 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.342273e-06 5.630 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.755448e-06 5.560 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.788758e-06 5.422 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.114105e-05 4.953 0 0
Signaling by Hippo R-HSA-2028269 1.161865e-05 4.935 0 0
Mitotic Anaphase R-HSA-68882 1.519021e-05 4.818 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.692816e-05 4.771 0 0
Apoptotic execution phase R-HSA-75153 2.099903e-05 4.678 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.964615e-05 4.528 0 0
L1CAM interactions R-HSA-373760 5.687887e-05 4.245 0 0
Post NMDA receptor activation events R-HSA-438064 6.163708e-05 4.210 0 0
Separation of Sister Chromatids R-HSA-2467813 8.458262e-05 4.073 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.266289e-04 3.897 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.351495e-04 3.869 0 0
Membrane Trafficking R-HSA-199991 1.908406e-04 3.719 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.402301e-04 3.619 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.285274e-04 3.483 0 0
Chromatin organization R-HSA-4839726 3.503848e-04 3.455 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.093536e-04 3.388 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.199117e-04 3.377 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.130554e-04 3.384 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.093536e-04 3.388 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.280658e-04 3.368 0 0
Axon guidance R-HSA-422475 4.488887e-04 3.348 0 0
Nervous system development R-HSA-9675108 4.454605e-04 3.351 0 0
Mitotic Prophase R-HSA-68875 4.545097e-04 3.342 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 4.735756e-04 3.325 0 0
Cellular response to heat stress R-HSA-3371556 5.111581e-04 3.291 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.206053e-04 3.283 0 0
Mitotic Spindle Checkpoint R-HSA-69618 5.535729e-04 3.257 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 6.458962e-04 3.190 0 0
Amplification of signal from the kinetochores R-HSA-141424 6.333628e-04 3.198 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 6.333628e-04 3.198 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 6.230412e-04 3.205 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 7.138269e-04 3.146 0 0
MTOR signalling R-HSA-165159 7.614557e-04 3.118 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.989231e-04 3.097 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 8.299285e-04 3.081 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.034381e-03 2.985 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.043423e-03 2.982 0 0
Long-term potentiation R-HSA-9620244 1.009115e-03 2.996 0 0
Nuclear import of Rev protein R-HSA-180746 1.021096e-03 2.991 0 0
Regulation of PTEN gene transcription R-HSA-8943724 9.992787e-04 3.000 0 0
HIV Life Cycle R-HSA-162587 1.155244e-03 2.937 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.239458e-03 2.907 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.197880e-03 2.922 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.248991e-03 2.903 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.299265e-03 2.886 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.299265e-03 2.886 0 0
NRAGE signals death through JNK R-HSA-193648 1.310203e-03 2.883 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.432624e-03 2.844 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.594917e-03 2.797 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.594917e-03 2.797 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.553907e-03 2.809 0 0
mTORC1-mediated signalling R-HSA-166208 1.601383e-03 2.796 0 0
Chromatin modifying enzymes R-HSA-3247509 1.621153e-03 2.790 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.757541e-03 2.755 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.775370e-03 2.751 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.998189e-03 2.699 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.998189e-03 2.699 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.998189e-03 2.699 0 0
Recycling pathway of L1 R-HSA-437239 1.908158e-03 2.719 0 0
snRNP Assembly R-HSA-191859 2.097232e-03 2.678 0 0
Metabolism of non-coding RNA R-HSA-194441 2.097232e-03 2.678 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.099726e-03 2.678 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.206295e-03 2.656 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.448725e-03 2.611 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 2.468553e-03 2.608 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.446744e-03 2.611 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.448725e-03 2.611 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.723706e-03 2.565 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.748302e-03 2.561 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.748302e-03 2.561 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.819355e-03 2.550 0 0
Cellular Senescence R-HSA-2559583 2.875361e-03 2.541 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.171483e-03 2.499 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 3.265221e-03 2.486 0 0
Cell-Cell communication R-HSA-1500931 3.271679e-03 2.485 0 0
Aggrephagy R-HSA-9646399 3.286052e-03 2.483 0 0
Autophagy R-HSA-9612973 3.501465e-03 2.456 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.677279e-03 2.434 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.808463e-03 2.419 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.646707e-03 2.438 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.008438e-03 2.397 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.008438e-03 2.397 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 4.071014e-03 2.390 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.111540e-03 2.386 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.111540e-03 2.386 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.111540e-03 2.386 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.008438e-03 2.397 0 0
Signaling by RAS mutants R-HSA-6802949 4.111540e-03 2.386 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.008438e-03 2.397 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.188204e-03 2.378 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.188204e-03 2.378 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.188204e-03 2.378 0 0
HIV Infection R-HSA-162906 4.453168e-03 2.351 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.618040e-03 2.336 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.146920e-03 2.288 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.073306e-03 2.295 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.227400e-03 2.282 0 0
Death Receptor Signaling R-HSA-73887 5.227400e-03 2.282 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 5.274116e-03 2.278 0 0
Transport of connexons to the plasma membrane R-HSA-190872 5.274116e-03 2.278 0 0
MAPK family signaling cascades R-HSA-5683057 5.427540e-03 2.265 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 6.040676e-03 2.219 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.040676e-03 2.219 0 0
Late Phase of HIV Life Cycle R-HSA-162599 6.027164e-03 2.220 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 5.675945e-03 2.246 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 5.708268e-03 2.243 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 5.675945e-03 2.246 0 0
Signaling by ALK in cancer R-HSA-9700206 5.708268e-03 2.243 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 6.116214e-03 2.214 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 6.166452e-03 2.210 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.530122e-03 2.185 0 0
Centrosome maturation R-HSA-380287 7.731155e-03 2.112 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 8.474031e-03 2.072 0 0
Negative regulation of MET activity R-HSA-6807004 8.474031e-03 2.072 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 8.571060e-03 2.067 0 0
Generation of second messenger molecules R-HSA-202433 8.418101e-03 2.075 0 0
Mitotic G2-G2/M phases R-HSA-453274 8.774418e-03 2.057 0 0
Macroautophagy R-HSA-1632852 8.956874e-03 2.048 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 9.022942e-03 2.045 0 0
Host Interactions of HIV factors R-HSA-162909 9.458852e-03 2.024 0 0
Apoptosis R-HSA-109581 9.673836e-03 2.014 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 9.810157e-03 2.008 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 9.887022e-03 2.005 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.098609e-02 1.959 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.098609e-02 1.959 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.098609e-02 1.959 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.098609e-02 1.959 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.098609e-02 1.959 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.098609e-02 1.959 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.098609e-02 1.959 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.098609e-02 1.959 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.098609e-02 1.959 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.098609e-02 1.959 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.098609e-02 1.959 0 0
EGFR downregulation R-HSA-182971 1.069621e-02 1.971 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.070311e-02 1.970 0 0
Cell junction organization R-HSA-446728 1.087575e-02 1.964 0 0
G alpha (12/13) signalling events R-HSA-416482 1.078143e-02 1.967 0 0
Myogenesis R-HSA-525793 1.187082e-02 1.926 0 0
Signaling by ERBB2 R-HSA-1227986 1.230115e-02 1.910 0 0
Cell Cycle Checkpoints R-HSA-69620 1.232654e-02 1.909 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.253368e-02 1.902 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.380509e-02 1.860 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.294316e-02 1.888 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.294316e-02 1.888 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.306198e-02 1.884 0 0
G0 and Early G1 R-HSA-1538133 1.266182e-02 1.898 0 0
Diseases of mitotic cell cycle R-HSA-9675126 1.266182e-02 1.898 0 0
ESR-mediated signaling R-HSA-8939211 1.317600e-02 1.880 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.363184e-02 1.865 0 0
Regulation of TP53 Activity R-HSA-5633007 1.391217e-02 1.857 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.421158e-02 1.847 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.517438e-02 1.819 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.573247e-02 1.803 0 0
Inositol phosphate metabolism R-HSA-1483249 1.642430e-02 1.785 0 0
mRNA Splicing R-HSA-72172 1.644622e-02 1.784 0 0
Signaling by PTK6 R-HSA-8848021 1.737491e-02 1.760 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 1.737491e-02 1.760 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 1.746485e-02 1.758 0 0
MET interacts with TNS proteins R-HSA-8875513 1.976079e-02 1.704 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 1.988933e-02 1.701 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 1.893226e-02 1.723 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.906294e-02 1.720 0 0
G2/M Transition R-HSA-69275 1.969686e-02 1.706 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 1.812511e-02 1.742 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 1.999049e-02 1.699 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.071786e-02 1.684 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.197464e-02 1.658 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.197464e-02 1.658 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.197464e-02 1.658 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.197464e-02 1.658 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.197464e-02 1.658 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.197464e-02 1.658 0 0
DCC mediated attractive signaling R-HSA-418885 2.236384e-02 1.650 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.236384e-02 1.650 0 0
Interleukin-37 signaling R-HSA-9008059 2.327223e-02 1.633 0 0
Oncogene Induced Senescence R-HSA-2559585 2.331278e-02 1.632 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 2.529807e-02 1.597 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.538145e-02 1.595 0 0
MHC class II antigen presentation R-HSA-2132295 2.608296e-02 1.584 0 0
Signal transduction by L1 R-HSA-445144 2.529807e-02 1.597 0 0
Trafficking of AMPA receptors R-HSA-399719 2.704676e-02 1.568 0 0
Kinesins R-HSA-983189 2.538145e-02 1.595 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.437400e-02 1.613 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.667716e-02 1.574 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.667716e-02 1.574 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.428262e-02 1.615 0 0
Prolonged ERK activation events R-HSA-169893 2.774708e-02 1.557 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.793872e-02 1.554 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.793872e-02 1.554 0 0
Viral Messenger RNA Synthesis R-HSA-168325 2.818180e-02 1.550 0 0
HATs acetylate histones R-HSA-3214847 2.858470e-02 1.544 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.919267e-02 1.535 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 2.919676e-02 1.535 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 2.992594e-02 1.524 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.056712e-02 1.515 0 0
Heme signaling R-HSA-9707616 3.120273e-02 1.506 0 0
tRNA processing in the nucleus R-HSA-6784531 3.120273e-02 1.506 0 0
NADE modulates death signalling R-HSA-205025 3.146329e-02 1.502 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 3.146329e-02 1.502 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 3.146329e-02 1.502 0 0
Gap junction trafficking and regulation R-HSA-157858 3.164800e-02 1.500 0 0
Signaling by EGFR R-HSA-177929 3.326277e-02 1.478 0 0
PTEN Regulation R-HSA-6807070 3.557903e-02 1.449 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.584954e-02 1.446 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 3.584954e-02 1.446 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.595758e-02 1.444 0 0
Repression of WNT target genes R-HSA-4641265 3.686207e-02 1.433 0 0
Gap junction trafficking R-HSA-190828 3.737800e-02 1.427 0 0
Type I hemidesmosome assembly R-HSA-446107 3.752369e-02 1.426 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.752369e-02 1.426 0 0
Formation of annular gap junctions R-HSA-196025 3.752369e-02 1.426 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.752369e-02 1.426 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.866598e-02 1.413 0 0
HSF1-dependent transactivation R-HSA-3371571 3.932861e-02 1.405 0 0
NrCAM interactions R-HSA-447038 4.606061e-02 1.337 0 0
G2 Phase R-HSA-68911 4.606061e-02 1.337 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 4.565951e-02 1.340 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.594238e-02 1.338 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.565951e-02 1.340 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.877158e-02 1.312 0 0
Gap junction degradation R-HSA-190873 4.877158e-02 1.312 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.877158e-02 1.312 0 0
ALK mutants bind TKIs R-HSA-9700645 4.877158e-02 1.312 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 5.560362e-02 1.255 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 5.560362e-02 1.255 0 0
Ephrin signaling R-HSA-3928664 4.877062e-02 1.312 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.922447e-02 1.308 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.688255e-02 1.245 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.688255e-02 1.245 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.499140e-02 1.260 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 5.499140e-02 1.260 0 0
MAP2K and MAPK activation R-HSA-5674135 5.533615e-02 1.257 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 5.119409e-02 1.291 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 5.119409e-02 1.291 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.877062e-02 1.312 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.499140e-02 1.260 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.580794e-02 1.253 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.015910e-02 1.300 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.877062e-02 1.312 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.389082e-02 1.268 0 0
PIP3 activates AKT signaling R-HSA-1257604 5.087799e-02 1.293 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.499140e-02 1.260 0 0
Regulation of KIT signaling R-HSA-1433559 5.560362e-02 1.255 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 4.877158e-02 1.312 0 0
Neurodegenerative Diseases R-HSA-8863678 5.688255e-02 1.245 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.688255e-02 1.245 0 0
Vesicle-mediated transport R-HSA-5653656 4.887633e-02 1.311 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 4.957339e-02 1.305 0 0
Cilium Assembly R-HSA-5617833 5.619285e-02 1.250 0 0
Deubiquitination R-HSA-5688426 4.847619e-02 1.314 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.822910e-02 1.317 0 0
Signaling by VEGF R-HSA-194138 5.191210e-02 1.285 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.560362e-02 1.255 0 0
Selective autophagy R-HSA-9663891 5.382080e-02 1.269 0 0
PKMTs methylate histone lysines R-HSA-3214841 4.957339e-02 1.305 0 0
Glycolysis R-HSA-70171 5.248987e-02 1.280 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.922447e-02 1.308 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.877062e-02 1.312 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.748518e-02 1.240 0 0
Regulation of TP53 Degradation R-HSA-6804757 5.892449e-02 1.230 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.902629e-02 1.229 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 6.023801e-02 1.220 0 0
Ca-dependent events R-HSA-111996 6.152282e-02 1.211 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.167425e-02 1.210 0 0
2-LTR circle formation R-HSA-164843 6.167425e-02 1.210 0 0
Regulation of CDH11 function R-HSA-9762292 6.167425e-02 1.210 0 0
Signal attenuation R-HSA-74749 6.167425e-02 1.210 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 6.292496e-02 1.201 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.341961e-02 1.198 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.341961e-02 1.198 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.341961e-02 1.198 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 6.341961e-02 1.198 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 6.341961e-02 1.198 0 0
Cellular responses to stress R-HSA-2262752 6.397376e-02 1.194 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.401850e-02 1.194 0 0
Semaphorin interactions R-HSA-373755 6.434623e-02 1.191 0 0
TGFBR3 expression R-HSA-9839394 6.523883e-02 1.185 0 0
HDMs demethylate histones R-HSA-3214842 6.523883e-02 1.185 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.570167e-02 1.182 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 6.590349e-02 1.181 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.333661e-02 1.079 0 0
Signaling by LTK in cancer R-HSA-9842640 8.333661e-02 1.079 0 0
CREB phosphorylation R-HSA-199920 8.333661e-02 1.079 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 8.333661e-02 1.079 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 8.333661e-02 1.079 0 0
PECAM1 interactions R-HSA-210990 7.619317e-02 1.118 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 7.619317e-02 1.118 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.669787e-02 1.176 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.429831e-02 1.129 0 0
mRNA 3'-end processing R-HSA-72187 8.310334e-02 1.080 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 8.310334e-02 1.080 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 7.624034e-02 1.118 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.890873e-02 1.162 0 0
EPHB-mediated forward signaling R-HSA-3928662 7.519332e-02 1.124 0 0
Nephrin family interactions R-HSA-373753 6.707366e-02 1.173 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.875867e-02 1.104 0 0
Cell-cell junction organization R-HSA-421270 7.910879e-02 1.102 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 7.893137e-02 1.103 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.521599e-02 1.124 0 0
Netrin-1 signaling R-HSA-373752 7.519332e-02 1.124 0 0
Interleukin-2 signaling R-HSA-9020558 7.619317e-02 1.118 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.469729e-02 1.127 0 0
Nuclear RNA decay R-HSA-9930044 7.875867e-02 1.104 0 0
DAG and IP3 signaling R-HSA-1489509 8.268532e-02 1.083 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.799698e-02 1.168 0 0
Meiosis R-HSA-1500620 6.799698e-02 1.168 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 7.875867e-02 1.104 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.875867e-02 1.104 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 8.136280e-02 1.090 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 6.959255e-02 1.157 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 7.519332e-02 1.124 0 0
Nef and signal transduction R-HSA-164944 8.333661e-02 1.079 0 0
Cell-extracellular matrix interactions R-HSA-446353 6.669787e-02 1.176 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 6.995666e-02 1.155 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.691353e-02 1.174 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 7.835508e-02 1.106 0 0
Programmed Cell Death R-HSA-5357801 8.258281e-02 1.083 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.131388e-02 1.147 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 8.406088e-02 1.075 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 8.785394e-02 1.056 0 0
Striated Muscle Contraction R-HSA-390522 8.785394e-02 1.056 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.984734e-02 1.046 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 9.053696e-02 1.043 0 0
Meiotic synapsis R-HSA-1221632 9.053696e-02 1.043 0 0
Cellular responses to stimuli R-HSA-8953897 9.200591e-02 1.036 0 0
Integration of provirus R-HSA-162592 9.226361e-02 1.035 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 9.227980e-02 1.035 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 9.227980e-02 1.035 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 9.452145e-02 1.024 0 0
S Phase R-HSA-69242 9.498430e-02 1.022 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.641714e-02 1.016 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 9.718907e-02 1.012 0 0
PLC beta mediated events R-HSA-112043 9.718907e-02 1.012 0 0
Gap junction assembly R-HSA-190861 9.753341e-02 1.011 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 9.883384e-02 1.005 0 0
FLT3 Signaling R-HSA-9607240 9.883384e-02 1.005 0 0
Notch-HLH transcription pathway R-HSA-350054 1.010441e-01 0.995 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 1.010441e-01 0.995 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.010441e-01 0.995 0 0
Gene expression (Transcription) R-HSA-74160 1.044297e-01 0.981 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.048737e-01 0.979 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.048775e-01 0.979 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.051210e-01 0.978 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.055610e-01 0.976 0 0
IFNG signaling activates MAPKs R-HSA-9732724 1.055610e-01 0.976 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 1.055610e-01 0.976 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 1.055610e-01 0.976 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.056701e-01 0.976 0 0
Late endosomal microautophagy R-HSA-9615710 1.056701e-01 0.976 0 0
Specification of primordial germ cells R-HSA-9827857 1.067067e-01 0.972 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.068170e-01 0.971 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.068170e-01 0.971 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.068170e-01 0.971 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.068170e-01 0.971 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.068170e-01 0.971 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.068170e-01 0.971 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.068170e-01 0.971 0 0
Signalling to ERKs R-HSA-187687 1.077907e-01 0.967 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.077985e-01 0.967 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.083183e-01 0.965 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.097989e-01 0.959 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.097989e-01 0.959 0 0
Muscle contraction R-HSA-397014 1.103741e-01 0.957 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.104310e-01 0.957 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.104310e-01 0.957 0 0
Regulation of gap junction activity R-HSA-191650 1.480922e-01 0.829 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 1.480922e-01 0.829 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.480922e-01 0.829 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.480922e-01 0.829 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 1.480922e-01 0.829 0 0
Signaling by MAP2K mutants R-HSA-9652169 1.480922e-01 0.829 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.480922e-01 0.829 0 0
MET receptor recycling R-HSA-8875656 1.298138e-01 0.887 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.286947e-01 0.890 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.286947e-01 0.890 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.221646e-01 0.913 0 0
Regulation of signaling by CBL R-HSA-912631 1.385967e-01 0.858 0 0
Tight junction interactions R-HSA-420029 1.424294e-01 0.846 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.299690e-01 0.886 0 0
Nucleotide Excision Repair R-HSA-5696398 1.210146e-01 0.917 0 0
Signaling by MET R-HSA-6806834 1.306364e-01 0.884 0 0
Frs2-mediated activation R-HSA-170968 1.286947e-01 0.890 0 0
Adherens junctions interactions R-HSA-418990 1.384911e-01 0.859 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.298138e-01 0.887 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.170405e-01 0.932 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 1.140517e-01 0.943 0 0
Calmodulin induced events R-HSA-111933 1.186160e-01 0.926 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 1.424294e-01 0.846 0 0
CaM pathway R-HSA-111997 1.186160e-01 0.926 0 0
DNA Repair R-HSA-73894 1.224860e-01 0.912 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 1.395728e-01 0.855 0 0
PI Metabolism R-HSA-1483255 1.472706e-01 0.832 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 1.480922e-01 0.829 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.286947e-01 0.890 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 1.383180e-01 0.859 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.173152e-01 0.931 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.182941e-01 0.927 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.435698e-01 0.843 0 0
RUNX2 regulates bone development R-HSA-8941326 1.186160e-01 0.926 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 1.189496e-01 0.925 0 0
Signaling by Interleukins R-HSA-449147 1.284358e-01 0.891 0 0
G-protein mediated events R-HSA-112040 1.484618e-01 0.828 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.490456e-01 0.827 0 0
Metabolism of RNA R-HSA-8953854 1.528123e-01 0.816 0 0
ARMS-mediated activation R-HSA-170984 1.558024e-01 0.807 0 0
Lipophagy R-HSA-9613354 1.558024e-01 0.807 0 0
Unwinding of DNA R-HSA-176974 1.558024e-01 0.807 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.558024e-01 0.807 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.559382e-01 0.807 0 0
Formation of definitive endoderm R-HSA-9823730 1.559382e-01 0.807 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.559382e-01 0.807 0 0
TCR signaling R-HSA-202403 1.567387e-01 0.805 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.567903e-01 0.805 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.570246e-01 0.804 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.577244e-01 0.802 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.581906e-01 0.801 0 0
Smooth Muscle Contraction R-HSA-445355 1.581906e-01 0.801 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.598475e-01 0.796 0 0
Reproduction R-HSA-1474165 1.600253e-01 0.796 0 0
Signaling by TGFB family members R-HSA-9006936 1.615629e-01 0.792 0 0
MAP kinase activation R-HSA-450294 1.637851e-01 0.786 0 0
Glucose metabolism R-HSA-70326 1.656563e-01 0.781 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.682086e-01 0.774 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.700861e-01 0.769 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.700861e-01 0.769 0 0
p75NTR signals via NF-kB R-HSA-193639 1.700861e-01 0.769 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.700861e-01 0.769 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.700861e-01 0.769 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.700861e-01 0.769 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.700861e-01 0.769 0 0
Homology Directed Repair R-HSA-5693538 1.734006e-01 0.761 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.022298e-01 0.694 0 0
TWIK-related spinal cord K+ channel (TRESK) R-HSA-1299344 2.022298e-01 0.694 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.022298e-01 0.694 0 0
Hereditary fructose intolerance R-HSA-5657560 2.022298e-01 0.694 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 2.874552e-01 0.541 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 2.874552e-01 0.541 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.874552e-01 0.541 0 0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) R-HSA-5619045 2.874552e-01 0.541 0 0
Defective SLC34A2 causes PALM R-HSA-5687583 2.874552e-01 0.541 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.874552e-01 0.541 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.874552e-01 0.541 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 2.874552e-01 0.541 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.874552e-01 0.541 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.878605e-01 0.726 0 0
IRS activation R-HSA-74713 1.878605e-01 0.726 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.878605e-01 0.726 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 2.288566e-01 0.640 0 0
PKB-mediated events R-HSA-109703 2.288566e-01 0.640 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.288566e-01 0.640 0 0
PDE3B signalling R-HSA-165160 2.288566e-01 0.640 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.635805e-01 0.439 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.635805e-01 0.439 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 3.635805e-01 0.439 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.635805e-01 0.439 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.635805e-01 0.439 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.635805e-01 0.439 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.635805e-01 0.439 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.832313e-01 0.737 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 1.832313e-01 0.737 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 2.703651e-01 0.568 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.703651e-01 0.568 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 2.703651e-01 0.568 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.923194e-01 0.716 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.923194e-01 0.716 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.412629e-01 0.618 0 0
Activation of RAC1 R-HSA-428540 2.412629e-01 0.618 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.412629e-01 0.618 0 0
SOS-mediated signalling R-HSA-112412 3.118090e-01 0.506 0 0
Disinhibition of SNARE formation R-HSA-114516 3.118090e-01 0.506 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.118090e-01 0.506 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.315769e-01 0.365 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 4.315769e-01 0.365 0 0
Axonal growth stimulation R-HSA-209563 4.315769e-01 0.365 0 0
MET activates PTPN11 R-HSA-8865999 4.315769e-01 0.365 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.315769e-01 0.365 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.153950e-01 0.667 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.153950e-01 0.667 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.713263e-01 0.567 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.713263e-01 0.567 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.713263e-01 0.567 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 2.713263e-01 0.567 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.391743e-01 0.621 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.391743e-01 0.621 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.391743e-01 0.621 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.527287e-01 0.453 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.527287e-01 0.453 0 0
phospho-PLA2 pathway R-HSA-111995 3.527287e-01 0.453 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.527287e-01 0.453 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.527287e-01 0.453 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.527287e-01 0.453 0 0
HIV elongation arrest and recovery R-HSA-167287 1.903031e-01 0.721 0 0
Pausing and recovery of HIV elongation R-HSA-167290 1.903031e-01 0.721 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.017583e-01 0.520 0 0
CD28 dependent Vav1 pathway R-HSA-389359 3.017583e-01 0.520 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.635197e-01 0.579 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.074861e-01 0.683 0 0
RAF activation R-HSA-5673000 1.859072e-01 0.731 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.859072e-01 0.731 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.536352e-01 0.596 0 0
Deadenylation of mRNA R-HSA-429947 2.536352e-01 0.596 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.882973e-01 0.540 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.323372e-01 0.478 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.323372e-01 0.478 0 0
CRMPs in Sema3A signaling R-HSA-399956 3.323372e-01 0.478 0 0
Retrograde neurotrophin signalling R-HSA-177504 3.323372e-01 0.478 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.927635e-01 0.406 0 0
WNT mediated activation of DVL R-HSA-201688 3.927635e-01 0.406 0 0
Calcineurin activates NFAT R-HSA-2025928 3.927635e-01 0.406 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.923120e-01 0.308 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.923120e-01 0.308 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.923120e-01 0.308 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.923120e-01 0.308 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.747985e-01 0.561 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.878246e-01 0.726 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.133778e-01 0.504 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.133778e-01 0.504 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.133778e-01 0.504 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.133778e-01 0.504 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 3.628633e-01 0.440 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.386381e-01 0.470 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.316355e-01 0.365 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.316355e-01 0.365 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.316355e-01 0.365 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.180784e-01 0.497 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.180784e-01 0.497 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.931586e-01 0.405 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.931586e-01 0.405 0 0
Phosphorylation of the APC/C R-HSA-176412 3.931586e-01 0.405 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 2.841152e-01 0.547 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.841152e-01 0.547 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.696671e-01 0.569 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.639620e-01 0.439 0 0
Dual Incision in GG-NER R-HSA-5696400 3.195789e-01 0.495 0 0
Transcription of the HIV genome R-HSA-167172 2.457129e-01 0.610 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 3.193685e-01 0.496 0 0
HIV Transcription Initiation R-HSA-167161 3.193685e-01 0.496 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 3.193685e-01 0.496 0 0
FGFR2 alternative splicing R-HSA-6803529 3.892413e-01 0.410 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 4.230665e-01 0.374 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 4.230665e-01 0.374 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 4.691365e-01 0.329 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.691365e-01 0.329 0 0
Degradation of CDH1 R-HSA-9766229 3.181606e-01 0.497 0 0
Activation of the pre-replicative complex R-HSA-68962 3.841810e-01 0.415 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.841810e-01 0.415 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 3.553058e-01 0.449 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.818829e-01 0.550 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.317613e-01 0.479 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 4.524514e-01 0.344 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 4.524514e-01 0.344 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.090205e-01 0.510 0 0
MET promotes cell motility R-HSA-8875878 3.986577e-01 0.399 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 4.392743e-01 0.357 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.051155e-01 0.297 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.051155e-01 0.297 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.051155e-01 0.297 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.051155e-01 0.297 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.051155e-01 0.297 0 0
ERKs are inactivated R-HSA-202670 5.051155e-01 0.297 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.051155e-01 0.297 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 3.915889e-01 0.407 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.184673e-01 0.378 0 0
Translation initiation complex formation R-HSA-72649 4.018144e-01 0.396 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.638535e-01 0.334 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.381938e-01 0.358 0 0
HIV Transcription Elongation R-HSA-167169 4.381938e-01 0.358 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.381938e-01 0.358 0 0
Attenuation phase R-HSA-3371568 4.381938e-01 0.358 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 4.278966e-01 0.369 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 4.355020e-01 0.361 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 4.355020e-01 0.361 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.715098e-01 0.327 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.092074e-01 0.293 0 0
Regulation of CDH1 Function R-HSA-9764561 4.522713e-01 0.345 0 0
Dual incision in TC-NER R-HSA-6782135 4.689534e-01 0.329 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.620935e-01 0.335 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.469396e-01 0.350 0 0
PKR-mediated signaling R-HSA-9833482 2.961491e-01 0.528 0 0
Integrin signaling R-HSA-354192 2.808869e-01 0.551 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.216904e-01 0.283 0 0
G-protein beta:gamma signalling R-HSA-397795 4.499555e-01 0.347 0 0
EPH-Ephrin signaling R-HSA-2682334 2.686877e-01 0.571 0 0
Circadian clock R-HSA-9909396 4.087324e-01 0.389 0 0
HCMV Early Events R-HSA-9609690 1.920985e-01 0.716 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 3.786983e-01 0.422 0 0
DNA Damage Bypass R-HSA-73893 2.008757e-01 0.697 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.639620e-01 0.439 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 2.373905e-01 0.625 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.536352e-01 0.596 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.786466e-01 0.320 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.339883e-01 0.363 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 2.713263e-01 0.567 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.051155e-01 0.297 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.278966e-01 0.369 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.945844e-01 0.711 0 0
p75NTR regulates axonogenesis R-HSA-193697 3.927635e-01 0.406 0 0
PCP/CE pathway R-HSA-4086400 5.061384e-01 0.296 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 4.230665e-01 0.374 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.051155e-01 0.297 0 0
ERK/MAPK targets R-HSA-198753 3.386381e-01 0.470 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 3.180784e-01 0.497 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 4.524514e-01 0.344 0 0
DNA Double Strand Break Response R-HSA-5693606 3.432360e-01 0.464 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.194490e-01 0.284 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 2.311195e-01 0.636 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.981011e-01 0.526 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 4.418403e-01 0.355 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.527287e-01 0.453 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.316355e-01 0.365 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.316355e-01 0.365 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.689534e-01 0.329 0 0
PI3K Cascade R-HSA-109704 4.817574e-01 0.317 0 0
IGF1R signaling cascade R-HSA-2428924 4.260722e-01 0.371 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 4.230665e-01 0.374 0 0
GAB1 signalosome R-HSA-180292 4.811975e-01 0.318 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.878605e-01 0.726 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 2.391743e-01 0.621 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 3.927635e-01 0.406 0 0
PI3K/AKT activation R-HSA-198203 4.316355e-01 0.365 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.691365e-01 0.329 0 0
Polo-like kinase mediated events R-HSA-156711 4.811975e-01 0.318 0 0
Co-stimulation by CD28 R-HSA-389356 4.459651e-01 0.351 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.535625e-01 0.452 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 5.118666e-01 0.291 0 0
Killing mechanisms R-HSA-9664420 3.931586e-01 0.405 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 3.931586e-01 0.405 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.117660e-01 0.291 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.715098e-01 0.327 0 0
NF-kB is activated and signals survival R-HSA-209560 2.412629e-01 0.618 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.713263e-01 0.567 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 2.074861e-01 0.683 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.923120e-01 0.308 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.499555e-01 0.347 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 4.880393e-01 0.312 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.706465e-01 0.431 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.944760e-01 0.404 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 2.412629e-01 0.618 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 4.807114e-01 0.318 0 0
MyD88-independent TLR4 cascade R-HSA-166166 2.247372e-01 0.648 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 3.761688e-01 0.425 0 0
Switching of origins to a post-replicative state R-HSA-69052 4.323682e-01 0.364 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 2.247372e-01 0.648 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.796766e-01 0.746 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.981011e-01 0.526 0 0
Signaling by Nuclear Receptors R-HSA-9006931 2.527216e-01 0.597 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 2.874552e-01 0.541 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.878605e-01 0.726 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.878605e-01 0.726 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.153950e-01 0.667 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 2.635197e-01 0.579 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.230665e-01 0.374 0 0
Formation of the posterior neural plate R-HSA-9832991 4.691365e-01 0.329 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 4.143759e-01 0.383 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.286160e-01 0.483 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.316720e-01 0.479 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.927874e-01 0.307 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.166346e-01 0.380 0 0
Signaling by ROBO receptors R-HSA-376176 3.043409e-01 0.517 0 0
Signaling by WNT R-HSA-195721 5.175574e-01 0.286 0 0
Developmental Cell Lineages R-HSA-9734767 2.063584e-01 0.685 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.887395e-01 0.311 0 0
Ub-specific processing proteases R-HSA-5689880 2.017265e-01 0.695 0 0
Signaling by SCF-KIT R-HSA-1433557 2.235605e-01 0.651 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.963071e-01 0.528 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.392200e-01 0.470 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 4.343499e-01 0.362 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 3.323372e-01 0.478 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.628633e-01 0.440 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.808869e-01 0.551 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.856112e-01 0.544 0 0
Insulin receptor signalling cascade R-HSA-74751 4.260722e-01 0.371 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.855213e-01 0.314 0 0
Ca2+ pathway R-HSA-4086398 4.323682e-01 0.364 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 4.343499e-01 0.362 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.691570e-01 0.329 0 0
Neurexins and neuroligins R-HSA-6794361 5.168790e-01 0.287 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.691570e-01 0.329 0 0
Rap1 signalling R-HSA-392517 2.882973e-01 0.540 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.808869e-01 0.551 0 0
Interleukin-17 signaling R-HSA-448424 2.715040e-01 0.566 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.019499e-01 0.299 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 5.019499e-01 0.299 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.019499e-01 0.299 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 5.019499e-01 0.299 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.162968e-01 0.287 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 2.001002e-01 0.699 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.927635e-01 0.406 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.927635e-01 0.406 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 3.195789e-01 0.495 0 0
HCMV Infection R-HSA-9609646 4.163916e-01 0.380 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.882973e-01 0.540 0 0
Interferon Signaling R-HSA-913531 2.759031e-01 0.559 0 0
Opioid Signalling R-HSA-111885 3.235224e-01 0.490 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.823601e-01 0.418 0 0
Inhibition of PKR R-HSA-169131 2.022298e-01 0.694 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.874552e-01 0.541 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.635805e-01 0.439 0 0
Negative regulation of FLT3 R-HSA-9706369 1.923194e-01 0.716 0 0
Regulation of PTEN localization R-HSA-8948747 3.118090e-01 0.506 0 0
MET activates STAT3 R-HSA-8875791 4.315769e-01 0.365 0 0
Type II Na+/Pi cotransporters R-HSA-427589 4.315769e-01 0.365 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 3.017583e-01 0.520 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 3.927635e-01 0.406 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.927635e-01 0.406 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.668531e-01 0.574 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 3.195789e-01 0.495 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.716407e-01 0.566 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.691365e-01 0.329 0 0
Bicarbonate transporters R-HSA-425381 4.691365e-01 0.329 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 2.981011e-01 0.526 0 0
Budding and maturation of HIV virion R-HSA-162588 4.062317e-01 0.391 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.951315e-01 0.403 0 0
RNA Polymerase II Transcription R-HSA-73857 2.054906e-01 0.687 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.889330e-01 0.311 0 0
Developmental Biology R-HSA-1266738 1.907508e-01 0.720 0 0
Activation of BH3-only proteins R-HSA-114452 2.251929e-01 0.647 0 0
Generic Transcription Pathway R-HSA-212436 3.485755e-01 0.458 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.741178e-01 0.759 0 0
NGF-stimulated transcription R-HSA-9031628 3.017870e-01 0.520 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.230665e-01 0.374 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 3.915889e-01 0.407 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.516059e-01 0.454 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.516059e-01 0.454 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.516059e-01 0.454 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.844541e-01 0.546 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.943097e-01 0.404 0 0
Ion homeostasis R-HSA-5578775 3.010715e-01 0.521 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 3.422206e-01 0.466 0 0
FLT3 signaling in disease R-HSA-9682385 3.589827e-01 0.445 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.288566e-01 0.640 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 3.323372e-01 0.478 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.927635e-01 0.406 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.923120e-01 0.308 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.628633e-01 0.440 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.986577e-01 0.399 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.330185e-01 0.633 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 5.117660e-01 0.291 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.800988e-01 0.319 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.927874e-01 0.307 0 0
Signaling by NOTCH1 R-HSA-1980143 3.531067e-01 0.452 0 0
TNF signaling R-HSA-75893 4.355020e-01 0.361 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 1.903031e-01 0.721 0 0
G2/M Checkpoints R-HSA-69481 4.380596e-01 0.358 0 0
Interleukin-2 family signaling R-HSA-451927 4.381938e-01 0.358 0 0
Rab regulation of trafficking R-HSA-9007101 5.138406e-01 0.289 0 0
Transmission across Chemical Synapses R-HSA-112315 5.055326e-01 0.296 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.619513e-01 0.582 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 4.524514e-01 0.344 0 0
Signaling by NTRKs R-HSA-166520 2.544074e-01 0.594 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.892413e-01 0.410 0 0
TBC/RABGAPs R-HSA-8854214 3.553058e-01 0.449 0 0
Signaling by FGFR in disease R-HSA-1226099 3.253535e-01 0.488 0 0
Ion transport by P-type ATPases R-HSA-936837 2.997818e-01 0.523 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.235605e-01 0.651 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.874552e-01 0.541 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 2.288566e-01 0.640 0 0
DSCAM interactions R-HSA-376172 3.635805e-01 0.439 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.703651e-01 0.568 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.017583e-01 0.520 0 0
Regulation of gene expression in beta cells R-HSA-210745 2.074861e-01 0.683 0 0
Sensory perception of sour taste R-HSA-9729555 4.923120e-01 0.308 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.923120e-01 0.308 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.923120e-01 0.308 0 0
Signaling by NODAL R-HSA-1181150 3.133778e-01 0.504 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.628633e-01 0.440 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.691365e-01 0.329 0 0
Synthesis of PI R-HSA-1483226 4.691365e-01 0.329 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.253535e-01 0.488 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.051155e-01 0.297 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 4.715098e-01 0.327 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 3.016348e-01 0.521 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 5.019499e-01 0.299 0 0
Signaling by TGFBR3 R-HSA-9839373 4.097590e-01 0.387 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 3.118090e-01 0.506 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.527287e-01 0.453 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 3.392200e-01 0.470 0 0
Suppression of apoptosis R-HSA-9635465 4.691365e-01 0.329 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.940280e-01 0.712 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 5.117660e-01 0.291 0 0
Syndecan interactions R-HSA-3000170 4.143759e-01 0.383 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.499555e-01 0.347 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.118090e-01 0.506 0 0
Sodium/Proton exchangers R-HSA-425986 3.527287e-01 0.453 0 0
RSK activation R-HSA-444257 3.527287e-01 0.453 0 0
Regulation of HMOX1 expression and activity R-HSA-9707587 4.923120e-01 0.308 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.316355e-01 0.365 0 0
Gene Silencing by RNA R-HSA-211000 1.971262e-01 0.705 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.499555e-01 0.347 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 3.986577e-01 0.399 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.931586e-01 0.405 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.552141e-01 0.450 0 0
Interleukin-7 signaling R-HSA-1266695 2.747985e-01 0.561 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.963071e-01 0.528 0 0
SARS-CoV-1-host interactions R-HSA-9692914 3.586083e-01 0.445 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.153950e-01 0.667 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.927635e-01 0.406 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.118090e-01 0.506 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.527287e-01 0.453 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.323372e-01 0.478 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.927635e-01 0.406 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.691365e-01 0.329 0 0
Regulation of beta-cell development R-HSA-186712 4.855213e-01 0.314 0 0
Josephin domain DUBs R-HSA-5689877 4.316355e-01 0.365 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.316355e-01 0.365 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.931586e-01 0.405 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 4.355020e-01 0.361 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.691365e-01 0.329 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.818829e-01 0.550 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.141237e-01 0.503 0 0
IRE1alpha activates chaperones R-HSA-381070 3.565670e-01 0.448 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.204879e-01 0.657 0 0
Insulin processing R-HSA-264876 5.117660e-01 0.291 0 0
Interleukin-12 signaling R-HSA-9020591 3.531067e-01 0.452 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.882973e-01 0.540 0 0
Signaling by Leptin R-HSA-2586552 4.316355e-01 0.365 0 0
Formation of apoptosome R-HSA-111458 4.316355e-01 0.365 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.051155e-01 0.297 0 0
Growth hormone receptor signaling R-HSA-982772 4.143759e-01 0.383 0 0
Interleukin-12 family signaling R-HSA-447115 5.216904e-01 0.283 0 0
Adaptive Immune System R-HSA-1280218 5.332444e-01 0.273 0 0
Cyclin D associated events in G1 R-HSA-69231 5.340967e-01 0.272 0 0
G1 Phase R-HSA-69236 5.340967e-01 0.272 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.342943e-01 0.272 0 0
G1/S-Specific Transcription R-HSA-69205 5.343263e-01 0.272 0 0
HSF1 activation R-HSA-3371511 5.343263e-01 0.272 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.343263e-01 0.272 0 0
RNA Polymerase III Transcription R-HSA-74158 5.343263e-01 0.272 0 0
RET signaling R-HSA-8853659 5.343263e-01 0.272 0 0
Telomere Extension By Telomerase R-HSA-171319 5.349761e-01 0.272 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.349761e-01 0.272 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.349761e-01 0.272 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.364010e-01 0.271 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.364010e-01 0.271 0 0
MET activates RAS signaling R-HSA-8851805 5.394699e-01 0.268 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.394699e-01 0.268 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.394699e-01 0.268 0 0
Pervasive developmental disorders R-HSA-9005895 5.394699e-01 0.268 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 5.394699e-01 0.268 0 0
Disorders of Nervous System Development R-HSA-9697154 5.394699e-01 0.268 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.394699e-01 0.268 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.394699e-01 0.268 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.394699e-01 0.268 0 0
OAS antiviral response R-HSA-8983711 5.394699e-01 0.268 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 5.465608e-01 0.262 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 5.465608e-01 0.262 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.465608e-01 0.262 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.465608e-01 0.262 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 5.465608e-01 0.262 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.465608e-01 0.262 0 0
Activation of AKT2 R-HSA-165158 5.465608e-01 0.262 0 0
Reelin signalling pathway R-HSA-8866376 5.465608e-01 0.262 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.465608e-01 0.262 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.465608e-01 0.262 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.465608e-01 0.262 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.465608e-01 0.262 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.491050e-01 0.260 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.524753e-01 0.258 0 0
Nucleosome assembly R-HSA-774815 5.524753e-01 0.258 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.524753e-01 0.258 0 0
Fanconi Anemia Pathway R-HSA-6783310 5.524753e-01 0.258 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.576199e-01 0.254 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.576199e-01 0.254 0 0
Influenza Infection R-HSA-168255 5.597995e-01 0.252 0 0
Chromosome Maintenance R-HSA-73886 5.602202e-01 0.252 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.605333e-01 0.251 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.627140e-01 0.250 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.627140e-01 0.250 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.627140e-01 0.250 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.631133e-01 0.249 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 5.705150e-01 0.244 0 0
Diseases of DNA repair R-HSA-9675135 5.705150e-01 0.244 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.721361e-01 0.243 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.721361e-01 0.243 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 5.754062e-01 0.240 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.769411e-01 0.239 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.796556e-01 0.237 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 5.796556e-01 0.237 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.796556e-01 0.237 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.828091e-01 0.234 0 0
FOXO-mediated transcription R-HSA-9614085 5.866573e-01 0.232 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 5.880965e-01 0.231 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.880965e-01 0.231 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.880965e-01 0.231 0 0
Assembly Of The HIV Virion R-HSA-175474 5.880965e-01 0.231 0 0
Adipogenesis R-HSA-9843745 5.926692e-01 0.227 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 5.931672e-01 0.227 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.950157e-01 0.225 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.950157e-01 0.225 0 0
Cam-PDE 1 activation R-HSA-111957 5.950157e-01 0.225 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.950157e-01 0.225 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.950157e-01 0.225 0 0
Phosphorylation of Emi1 R-HSA-176417 5.950157e-01 0.225 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.950157e-01 0.225 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 5.950157e-01 0.225 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.950157e-01 0.225 0 0
Signaling by MAPK mutants R-HSA-9652817 5.950157e-01 0.225 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.950157e-01 0.225 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.950157e-01 0.225 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.950157e-01 0.225 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 5.950157e-01 0.225 0 0
Ceramide signalling R-HSA-193681 5.950157e-01 0.225 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.950157e-01 0.225 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.950157e-01 0.225 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.950157e-01 0.225 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.970020e-01 0.224 0 0
IRS-mediated signalling R-HSA-112399 6.003507e-01 0.222 0 0
Downstream signal transduction R-HSA-186763 6.010483e-01 0.221 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.010483e-01 0.221 0 0
Protein folding R-HSA-391251 6.012909e-01 0.221 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.030824e-01 0.220 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 6.030824e-01 0.220 0 0
Signal regulatory protein family interactions R-HSA-391160 6.030824e-01 0.220 0 0
Physiological factors R-HSA-5578768 6.030824e-01 0.220 0 0
Intraflagellar transport R-HSA-5620924 6.054816e-01 0.218 0 0
Platelet activation, signaling and aggregation R-HSA-76002 6.078136e-01 0.216 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 6.111731e-01 0.214 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.112204e-01 0.214 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 6.121969e-01 0.213 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.125114e-01 0.213 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.125114e-01 0.213 0 0
LDL clearance R-HSA-8964038 6.125114e-01 0.213 0 0
G1/S Transition R-HSA-69206 6.157709e-01 0.211 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.211048e-01 0.207 0 0
DNA strand elongation R-HSA-69190 6.217698e-01 0.206 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 6.305525e-01 0.200 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.305525e-01 0.200 0 0
Erythropoietin activates RAS R-HSA-9027284 6.323036e-01 0.199 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.323036e-01 0.199 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.323036e-01 0.199 0 0
p38MAPK events R-HSA-171007 6.323036e-01 0.199 0 0
Protein methylation R-HSA-8876725 6.323036e-01 0.199 0 0
Formation of the anterior neural plate R-HSA-9823739 6.323036e-01 0.199 0 0
Signaling by Activin R-HSA-1502540 6.323036e-01 0.199 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.337862e-01 0.198 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 6.359334e-01 0.197 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.359334e-01 0.197 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.359334e-01 0.197 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.359334e-01 0.197 0 0
Platelet degranulation R-HSA-114608 6.370548e-01 0.196 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.382953e-01 0.195 0 0
STAT5 Activation R-HSA-9645135 6.382953e-01 0.195 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.382953e-01 0.195 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.382953e-01 0.195 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 6.382953e-01 0.195 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.382953e-01 0.195 0 0
MET Receptor Activation R-HSA-6806942 6.382953e-01 0.195 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.382953e-01 0.195 0 0
NADPH regeneration R-HSA-389542 6.382953e-01 0.195 0 0
Neurofascin interactions R-HSA-447043 6.382953e-01 0.195 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.382953e-01 0.195 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 6.482792e-01 0.188 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.540333e-01 0.184 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.583475e-01 0.182 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.598148e-01 0.181 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.598148e-01 0.181 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.598148e-01 0.181 0 0
Fructose catabolism R-HSA-70350 6.598148e-01 0.181 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.598148e-01 0.181 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.598148e-01 0.181 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.598148e-01 0.181 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.611177e-01 0.180 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.611177e-01 0.180 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.654587e-01 0.177 0 0
Toll-like Receptor Cascades R-HSA-168898 6.672088e-01 0.176 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.676748e-01 0.175 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.676748e-01 0.175 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.704442e-01 0.174 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.756824e-01 0.170 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.769519e-01 0.169 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.769519e-01 0.169 0 0
TRIF-mediated programmed cell death R-HSA-2562578 6.769519e-01 0.169 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.769519e-01 0.169 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.769519e-01 0.169 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.769519e-01 0.169 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.769519e-01 0.169 0 0
Netrin mediated repulsion signals R-HSA-418886 6.769519e-01 0.169 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.769519e-01 0.169 0 0
PTK6 Expression R-HSA-8849473 6.769519e-01 0.169 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.769519e-01 0.169 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.769519e-01 0.169 0 0
VLDL clearance R-HSA-8964046 6.769519e-01 0.169 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.769519e-01 0.169 0 0
CHL1 interactions R-HSA-447041 6.769519e-01 0.169 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.769519e-01 0.169 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.797171e-01 0.168 0 0
Signaling by NOTCH2 R-HSA-1980145 6.797171e-01 0.168 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 6.797171e-01 0.168 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.797171e-01 0.168 0 0
Hyaluronan metabolism R-HSA-2142845 6.797171e-01 0.168 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.797474e-01 0.168 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 6.797474e-01 0.168 0 0
Hyaluronan degradation R-HSA-2160916 6.797474e-01 0.168 0 0
Amino acids regulate mTORC1 R-HSA-9639288 6.855716e-01 0.164 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 6.855716e-01 0.164 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.856478e-01 0.164 0 0
Disorders of Developmental Biology R-HSA-9675151 6.856478e-01 0.164 0 0
Synthesis of PG R-HSA-1483148 6.856478e-01 0.164 0 0
Cardiac conduction R-HSA-5576891 6.875339e-01 0.163 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.001352e-01 0.155 0 0
Metalloprotease DUBs R-HSA-5689901 7.001352e-01 0.155 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.001352e-01 0.155 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 7.001352e-01 0.155 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.001352e-01 0.155 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.001352e-01 0.155 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 7.002367e-01 0.155 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.002367e-01 0.155 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.031798e-01 0.153 0 0
Signaling by ERBB4 R-HSA-1236394 7.066012e-01 0.151 0 0
Potential therapeutics for SARS R-HSA-9679191 7.074233e-01 0.150 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.098469e-01 0.149 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.098469e-01 0.149 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 7.114792e-01 0.148 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.114792e-01 0.148 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.114792e-01 0.148 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.114792e-01 0.148 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.114792e-01 0.148 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.114792e-01 0.148 0 0
Adrenoceptors R-HSA-390696 7.114792e-01 0.148 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.114792e-01 0.148 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.114792e-01 0.148 0 0
Alpha-defensins R-HSA-1462054 7.114792e-01 0.148 0 0
Signaling by Insulin receptor R-HSA-74752 7.141395e-01 0.146 0 0
GPVI-mediated activation cascade R-HSA-114604 7.147363e-01 0.146 0 0
Mitochondrial biogenesis R-HSA-1592230 7.162831e-01 0.145 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 7.195193e-01 0.143 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 7.195193e-01 0.143 0 0
tRNA processing R-HSA-72306 7.251745e-01 0.140 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 7.275312e-01 0.138 0 0
Signaling by FGFR1 R-HSA-5654736 7.281627e-01 0.138 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 7.285436e-01 0.138 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.285436e-01 0.138 0 0
Regulation of TNFR1 signaling R-HSA-5357905 7.285436e-01 0.138 0 0
UCH proteinases R-HSA-5689603 7.308367e-01 0.136 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.311565e-01 0.136 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.311565e-01 0.136 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.324663e-01 0.135 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.324663e-01 0.135 0 0
Platelet sensitization by LDL R-HSA-432142 7.324663e-01 0.135 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.324663e-01 0.135 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.324663e-01 0.135 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 7.324663e-01 0.135 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 7.324663e-01 0.135 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.324663e-01 0.135 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.324663e-01 0.135 0 0
Nephron development R-HSA-9831926 7.324663e-01 0.135 0 0
Apoptotic factor-mediated response R-HSA-111471 7.324663e-01 0.135 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.379142e-01 0.132 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.379142e-01 0.132 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.423180e-01 0.129 0 0
MAPK1 (ERK2) activation R-HSA-112411 7.423180e-01 0.129 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 7.423180e-01 0.129 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 7.423180e-01 0.129 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.423180e-01 0.129 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.423180e-01 0.129 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.423180e-01 0.129 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.423180e-01 0.129 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 7.423180e-01 0.129 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 7.423180e-01 0.129 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.423180e-01 0.129 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.423180e-01 0.129 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.428913e-01 0.129 0 0
Response of endothelial cells to shear stress R-HSA-9860931 7.484182e-01 0.126 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 7.535672e-01 0.123 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 7.535672e-01 0.123 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.535672e-01 0.123 0 0
Translesion Synthesis by POLH R-HSA-110320 7.535672e-01 0.123 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.535672e-01 0.123 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.535672e-01 0.123 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.535672e-01 0.123 0 0
The NLRP3 inflammasome R-HSA-844456 7.535672e-01 0.123 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.536320e-01 0.123 0 0
mRNA Capping R-HSA-72086 7.553391e-01 0.122 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.553391e-01 0.122 0 0
Signaling by NOTCH R-HSA-157118 7.597446e-01 0.119 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.618463e-01 0.118 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.618463e-01 0.118 0 0
Extension of Telomeres R-HSA-180786 7.665256e-01 0.115 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.673677e-01 0.115 0 0
SLC transporter disorders R-HSA-5619102 7.678896e-01 0.115 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 7.698622e-01 0.114 0 0
Binding and entry of HIV virion R-HSA-173107 7.698622e-01 0.114 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.698622e-01 0.114 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 7.698622e-01 0.114 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.698622e-01 0.114 0 0
Arachidonate production from DAG R-HSA-426048 7.698622e-01 0.114 0 0
Pexophagy R-HSA-9664873 7.698622e-01 0.114 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.698622e-01 0.114 0 0
Tandem pore domain potassium channels R-HSA-1296346 7.698622e-01 0.114 0 0
DAP12 signaling R-HSA-2424491 7.718173e-01 0.112 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.718173e-01 0.112 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.732156e-01 0.112 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.732156e-01 0.112 0 0
Protein hydroxylation R-HSA-9629569 7.732156e-01 0.112 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.732156e-01 0.112 0 0
Signaling by FGFR2 R-HSA-5654738 7.751111e-01 0.111 0 0
Parasite infection R-HSA-9664407 7.753115e-01 0.111 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 7.753115e-01 0.111 0 0
Leishmania phagocytosis R-HSA-9664417 7.753115e-01 0.111 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 7.761091e-01 0.110 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 7.761091e-01 0.110 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.761358e-01 0.110 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.761358e-01 0.110 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.761358e-01 0.110 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.783801e-01 0.109 0 0
Interferon gamma signaling R-HSA-877300 7.799634e-01 0.108 0 0
Regulation of RAS by GAPs R-HSA-5658442 7.825563e-01 0.106 0 0
Signaling by FGFR R-HSA-190236 7.847642e-01 0.105 0 0
Synthesis of DNA R-HSA-69239 7.853401e-01 0.105 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.868672e-01 0.104 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.873754e-01 0.104 0 0
G-protein activation R-HSA-202040 7.914810e-01 0.102 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.914810e-01 0.102 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.914810e-01 0.102 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 7.914810e-01 0.102 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.914810e-01 0.102 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.914810e-01 0.102 0 0
Basigin interactions R-HSA-210991 7.914810e-01 0.102 0 0
Signalling to RAS R-HSA-167044 7.914810e-01 0.102 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.924000e-01 0.101 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.944636e-01 0.100 0 0
Signaling by APC mutants R-HSA-4839744 7.944636e-01 0.100 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.944636e-01 0.100 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.944636e-01 0.100 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.944636e-01 0.100 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.944636e-01 0.100 0 0
LGI-ADAM interactions R-HSA-5682910 7.944636e-01 0.100 0 0
vRNA Synthesis R-HSA-192814 7.944636e-01 0.100 0 0
vRNP Assembly R-HSA-192905 7.944636e-01 0.100 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.944636e-01 0.100 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.944636e-01 0.100 0 0
Prostanoid ligand receptors R-HSA-391908 7.944636e-01 0.100 0 0
Transport of RCbl within the body R-HSA-9758890 7.944636e-01 0.100 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.944636e-01 0.100 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.946748e-01 0.100 0 0
Meiotic recombination R-HSA-912446 7.946748e-01 0.100 0 0
Interleukin-1 family signaling R-HSA-446652 7.995326e-01 0.097 0 0
Signaling by PDGF R-HSA-186797 8.007168e-01 0.097 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.020426e-01 0.096 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.062571e-01 0.094 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.062571e-01 0.094 0 0
Orc1 removal from chromatin R-HSA-68949 8.062571e-01 0.094 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.062571e-01 0.094 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.084344e-01 0.092 0 0
Serine metabolism R-HSA-977347 8.084344e-01 0.092 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 8.164365e-01 0.088 0 0
Signaling by GSK3beta mutants R-HSA-5339716 8.164365e-01 0.088 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.164365e-01 0.088 0 0
Signaling by AXIN mutants R-HSA-4839735 8.164365e-01 0.088 0 0
Signaling by AMER1 mutants R-HSA-4839748 8.164365e-01 0.088 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.164365e-01 0.088 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.164365e-01 0.088 0 0
Sodium/Calcium exchangers R-HSA-425561 8.164365e-01 0.088 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 8.173142e-01 0.088 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 8.173142e-01 0.088 0 0
Assembly of the pre-replicative complex R-HSA-68867 8.204261e-01 0.086 0 0
Neuronal System R-HSA-112316 8.206429e-01 0.086 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.241476e-01 0.084 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.241476e-01 0.084 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 8.241476e-01 0.084 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.241476e-01 0.084 0 0
Fructose metabolism R-HSA-5652084 8.241476e-01 0.084 0 0
Signaling by KIT in disease R-HSA-9669938 8.241476e-01 0.084 0 0
Ethanol oxidation R-HSA-71384 8.241476e-01 0.084 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.252519e-01 0.083 0 0
Protein ubiquitination R-HSA-8852135 8.260300e-01 0.083 0 0
Signaling by FGFR4 R-HSA-5654743 8.265979e-01 0.083 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.288309e-01 0.082 0 0
Cellular response to hypoxia R-HSA-1234174 8.308967e-01 0.080 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.311855e-01 0.080 0 0
HCMV Late Events R-HSA-9610379 8.325803e-01 0.080 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 8.331664e-01 0.079 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.334834e-01 0.079 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.360614e-01 0.078 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.360614e-01 0.078 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 8.360614e-01 0.078 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.360614e-01 0.078 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 8.360614e-01 0.078 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 8.360614e-01 0.078 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 8.360614e-01 0.078 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 8.360614e-01 0.078 0 0
Leading Strand Synthesis R-HSA-69109 8.360614e-01 0.078 0 0
Polymerase switching R-HSA-69091 8.360614e-01 0.078 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.360614e-01 0.078 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 8.360614e-01 0.078 0 0
Regulation of IFNG signaling R-HSA-877312 8.360614e-01 0.078 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.360614e-01 0.078 0 0
Signaling by LTK R-HSA-9842663 8.360614e-01 0.078 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 8.360614e-01 0.078 0 0
Interleukin-15 signaling R-HSA-8983432 8.360614e-01 0.078 0 0
RMTs methylate histone arginines R-HSA-3214858 8.376286e-01 0.077 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 8.379029e-01 0.077 0 0
Signaling by NOTCH3 R-HSA-9012852 8.379029e-01 0.077 0 0
Paracetamol ADME R-HSA-9753281 8.379029e-01 0.077 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.386918e-01 0.076 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.386918e-01 0.076 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.386918e-01 0.076 0 0
Carnitine shuttle R-HSA-200425 8.386918e-01 0.076 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.410186e-01 0.075 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.410186e-01 0.075 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 8.410186e-01 0.075 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.418577e-01 0.075 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.418577e-01 0.075 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 8.474613e-01 0.072 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 8.474613e-01 0.072 0 0
Signaling by FGFR3 R-HSA-5654741 8.480650e-01 0.072 0 0
Neutrophil degranulation R-HSA-6798695 8.503371e-01 0.070 0 0
Integrin cell surface interactions R-HSA-216083 8.515110e-01 0.070 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.521374e-01 0.069 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.521374e-01 0.069 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.521374e-01 0.069 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.521374e-01 0.069 0 0
Regulation of Apoptosis R-HSA-169911 8.524475e-01 0.069 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 8.535893e-01 0.069 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.535893e-01 0.069 0 0
Formation of axial mesoderm R-HSA-9796292 8.535893e-01 0.069 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.535893e-01 0.069 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 8.535893e-01 0.069 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.535893e-01 0.069 0 0
Processing of SMDT1 R-HSA-8949664 8.535893e-01 0.069 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.535893e-01 0.069 0 0
Maturation of nucleoprotein R-HSA-9683610 8.535893e-01 0.069 0 0
Interleukin-6 signaling R-HSA-1059683 8.535893e-01 0.069 0 0
Diseases of programmed cell death R-HSA-9645723 8.548031e-01 0.068 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 8.573006e-01 0.067 0 0
Telomere Maintenance R-HSA-157579 8.584919e-01 0.066 0 0
SARS-CoV Infections R-HSA-9679506 8.611495e-01 0.065 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.617517e-01 0.065 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.631526e-01 0.064 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.631526e-01 0.064 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.645530e-01 0.063 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.645530e-01 0.063 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.645530e-01 0.063 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.645530e-01 0.063 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.672404e-01 0.062 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.692441e-01 0.061 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.692441e-01 0.061 0 0
Hydrolysis of LPC R-HSA-1483115 8.692441e-01 0.061 0 0
Malate-aspartate shuttle R-HSA-9856872 8.692441e-01 0.061 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.692441e-01 0.061 0 0
HDL assembly R-HSA-8963896 8.692441e-01 0.061 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.692441e-01 0.061 0 0
Zinc transporters R-HSA-435354 8.692441e-01 0.061 0 0
Degradation of DVL R-HSA-4641258 8.731683e-01 0.059 0 0
DNA Replication Pre-Initiation R-HSA-69002 8.748723e-01 0.058 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 8.760051e-01 0.057 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 8.760051e-01 0.057 0 0
Sphingolipid catabolism R-HSA-9845614 8.760051e-01 0.057 0 0
Metal ion SLC transporters R-HSA-425410 8.760228e-01 0.057 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.809487e-01 0.055 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 8.811301e-01 0.055 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.825292e-01 0.054 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.832258e-01 0.054 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.832258e-01 0.054 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.832258e-01 0.054 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.832258e-01 0.054 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.832258e-01 0.054 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.832258e-01 0.054 0 0
Translesion synthesis by REV1 R-HSA-110312 8.832258e-01 0.054 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.832258e-01 0.054 0 0
Biotin transport and metabolism R-HSA-196780 8.832258e-01 0.054 0 0
Other semaphorin interactions R-HSA-416700 8.832258e-01 0.054 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.832258e-01 0.054 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.836870e-01 0.054 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.842978e-01 0.053 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.842978e-01 0.053 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 8.865577e-01 0.052 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 8.865577e-01 0.052 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.865577e-01 0.052 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.865577e-01 0.052 0 0
Stabilization of p53 R-HSA-69541 8.912692e-01 0.050 0 0
Signaling by ALK R-HSA-201556 8.912692e-01 0.050 0 0
Immune System R-HSA-168256 8.929145e-01 0.049 0 0
Translesion synthesis by POLI R-HSA-5656121 8.957132e-01 0.048 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.957132e-01 0.048 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.957132e-01 0.048 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.957132e-01 0.048 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.957132e-01 0.048 0 0
Differentiation of T cells R-HSA-9945266 8.957132e-01 0.048 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.957132e-01 0.048 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.957132e-01 0.048 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.962721e-01 0.048 0 0
Inflammasomes R-HSA-622312 8.962721e-01 0.048 0 0
Gastrulation R-HSA-9758941 8.975622e-01 0.047 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 8.994214e-01 0.046 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.994214e-01 0.046 0 0
Diseases of Immune System R-HSA-5260271 8.994214e-01 0.046 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.994214e-01 0.046 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.020200e-01 0.045 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.049719e-01 0.043 0 0
Signaling by Erythropoietin R-HSA-9006335 9.052070e-01 0.043 0 0
Platelet calcium homeostasis R-HSA-418360 9.052070e-01 0.043 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.058708e-01 0.043 0 0
Translesion synthesis by POLK R-HSA-5655862 9.068659e-01 0.042 0 0
Phase 2 - plateau phase R-HSA-5576893 9.068659e-01 0.042 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.068659e-01 0.042 0 0
Heme assimilation R-HSA-9927020 9.068659e-01 0.042 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 9.068659e-01 0.042 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.068659e-01 0.042 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.068659e-01 0.042 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 9.114917e-01 0.040 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.127582e-01 0.040 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.140916e-01 0.039 0 0
Intra-Golgi traffic R-HSA-6811438 9.140916e-01 0.039 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.149299e-01 0.039 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 9.168265e-01 0.038 0 0
Glycogen storage diseases R-HSA-3229121 9.168265e-01 0.038 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.168265e-01 0.038 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 9.168265e-01 0.038 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.209575e-01 0.036 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.209575e-01 0.036 0 0
Cargo concentration in the ER R-HSA-5694530 9.209575e-01 0.036 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 9.209575e-01 0.036 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.209575e-01 0.036 0 0
RNA Polymerase I Transcription R-HSA-73864 9.218643e-01 0.035 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 9.220282e-01 0.035 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.238133e-01 0.034 0 0
HDACs deacetylate histones R-HSA-3214815 9.245018e-01 0.034 0 0
G alpha (z) signalling events R-HSA-418597 9.245018e-01 0.034 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 9.257223e-01 0.034 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 9.257223e-01 0.034 0 0
Tie2 Signaling R-HSA-210993 9.257223e-01 0.034 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.257223e-01 0.034 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.266395e-01 0.033 0 0
Sensory processing of sound R-HSA-9659379 9.266395e-01 0.033 0 0
Cellular response to chemical stress R-HSA-9711123 9.272248e-01 0.033 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.284047e-01 0.032 0 0
Downstream TCR signaling R-HSA-202424 9.292047e-01 0.032 0 0
Hedgehog 'off' state R-HSA-5610787 9.321859e-01 0.030 0 0
DAP12 interactions R-HSA-2172127 9.324678e-01 0.030 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.336671e-01 0.030 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.336671e-01 0.030 0 0
Pyrimidine biosynthesis R-HSA-500753 9.336671e-01 0.030 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.336671e-01 0.030 0 0
Other interleukin signaling R-HSA-449836 9.336671e-01 0.030 0 0
Specification of the neural plate border R-HSA-9834899 9.336671e-01 0.030 0 0
Maturation of nucleoprotein R-HSA-9694631 9.336671e-01 0.030 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.336671e-01 0.030 0 0
Recycling of bile acids and salts R-HSA-159418 9.342181e-01 0.030 0 0
Co-inhibition by PD-1 R-HSA-389948 9.346242e-01 0.029 0 0
Dectin-2 family R-HSA-5621480 9.348033e-01 0.029 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.377393e-01 0.028 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.396082e-01 0.027 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.400298e-01 0.027 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.400298e-01 0.027 0 0
Glycogen synthesis R-HSA-3322077 9.407626e-01 0.027 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.407626e-01 0.027 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.407626e-01 0.027 0 0
Pregnenolone biosynthesis R-HSA-196108 9.407626e-01 0.027 0 0
Synthesis of Ketone Bodies R-HSA-77111 9.407626e-01 0.027 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 9.407626e-01 0.027 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.424932e-01 0.026 0 0
Phospholipid metabolism R-HSA-1483257 9.430881e-01 0.025 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.438131e-01 0.025 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.438131e-01 0.025 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.442168e-01 0.025 0 0
Signal amplification R-HSA-392518 9.453512e-01 0.024 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.453512e-01 0.024 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.468536e-01 0.024 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.470995e-01 0.024 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.470995e-01 0.024 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.470995e-01 0.024 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.470995e-01 0.024 0 0
Lagging Strand Synthesis R-HSA-69186 9.470995e-01 0.024 0 0
Abacavir metabolism R-HSA-2161541 9.470995e-01 0.024 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.470995e-01 0.024 0 0
Synthesis of PC R-HSA-1483191 9.471584e-01 0.024 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.502209e-01 0.022 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.502209e-01 0.022 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.502209e-01 0.022 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.502209e-01 0.022 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.502209e-01 0.022 0 0
PERK regulates gene expression R-HSA-381042 9.502209e-01 0.022 0 0
Gluconeogenesis R-HSA-70263 9.513539e-01 0.022 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.516711e-01 0.022 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.527588e-01 0.021 0 0
Ribavirin ADME R-HSA-9755088 9.527588e-01 0.021 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.527588e-01 0.021 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.527588e-01 0.021 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.527588e-01 0.021 0 0
PPARA activates gene expression R-HSA-1989781 9.529962e-01 0.021 0 0
Signaling by NOTCH4 R-HSA-9013694 9.536695e-01 0.021 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.546745e-01 0.020 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.546745e-01 0.020 0 0
Glycosphingolipid transport R-HSA-9845576 9.546745e-01 0.020 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.546745e-01 0.020 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.546745e-01 0.020 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.565624e-01 0.019 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.565624e-01 0.019 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.578129e-01 0.019 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 9.578129e-01 0.019 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.578129e-01 0.019 0 0
Cellular hexose transport R-HSA-189200 9.578129e-01 0.019 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.578129e-01 0.019 0 0
Ion channel transport R-HSA-983712 9.584813e-01 0.018 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.585067e-01 0.018 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 9.585067e-01 0.018 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.587452e-01 0.018 0 0
Cellular response to starvation R-HSA-9711097 9.596356e-01 0.018 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.602568e-01 0.018 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.621475e-01 0.017 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.623267e-01 0.017 0 0
Biosynthesis of maresins R-HSA-9018682 9.623267e-01 0.017 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.623267e-01 0.017 0 0
Organic anion transport by SLCO transporters R-HSA-879518 9.623267e-01 0.017 0 0
Ketone body metabolism R-HSA-74182 9.623267e-01 0.017 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.624641e-01 0.017 0 0
Elastic fibre formation R-HSA-1566948 9.624641e-01 0.017 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.652139e-01 0.015 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.652139e-01 0.015 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.653926e-01 0.015 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.658598e-01 0.015 0 0
CYP2E1 reactions R-HSA-211999 9.663577e-01 0.015 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.663577e-01 0.015 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 9.663577e-01 0.015 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.663577e-01 0.015 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.663577e-01 0.015 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.663577e-01 0.015 0 0
Plasma lipoprotein assembly R-HSA-8963898 9.663577e-01 0.015 0 0
Interleukin-6 family signaling R-HSA-6783589 9.663577e-01 0.015 0 0
Base Excision Repair R-HSA-73884 9.667696e-01 0.015 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.670988e-01 0.015 0 0
Interleukin-1 signaling R-HSA-9020702 9.687311e-01 0.014 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.689588e-01 0.014 0 0
Glycogen metabolism R-HSA-8982491 9.689588e-01 0.014 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.689588e-01 0.014 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.689701e-01 0.014 0 0
Viral Infection Pathways R-HSA-9824446 9.694296e-01 0.013 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.695730e-01 0.013 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 9.699195e-01 0.013 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.699576e-01 0.013 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.699576e-01 0.013 0 0
G protein gated Potassium channels R-HSA-1296059 9.699576e-01 0.013 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.699576e-01 0.013 0 0
Laminin interactions R-HSA-3000157 9.699576e-01 0.013 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.699576e-01 0.013 0 0
DNA Replication R-HSA-69306 9.707957e-01 0.013 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.717857e-01 0.012 0 0
Maturation of spike protein R-HSA-9694548 9.717857e-01 0.012 0 0
Formation of the cornified envelope R-HSA-6809371 9.730179e-01 0.012 0 0
MET activates PTK2 signaling R-HSA-8874081 9.731725e-01 0.012 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 9.731725e-01 0.012 0 0
TRP channels R-HSA-3295583 9.731725e-01 0.012 0 0
Abacavir ADME R-HSA-2161522 9.731725e-01 0.012 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.731725e-01 0.012 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.743473e-01 0.011 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.743633e-01 0.011 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.743633e-01 0.011 0 0
COPII-mediated vesicle transport R-HSA-204005 9.759913e-01 0.011 0 0
RSV-host interactions R-HSA-9833110 9.760029e-01 0.011 0 0
Packaging Of Telomere Ends R-HSA-171306 9.760435e-01 0.011 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.760435e-01 0.011 0 0
Cristae formation R-HSA-8949613 9.760435e-01 0.011 0 0
Triglyceride biosynthesis R-HSA-75109 9.760435e-01 0.011 0 0
Synthesis of PE R-HSA-1483213 9.760435e-01 0.011 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.760435e-01 0.011 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.760435e-01 0.011 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.760435e-01 0.011 0 0
Collagen formation R-HSA-1474290 9.765205e-01 0.010 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.767126e-01 0.010 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.767126e-01 0.010 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.767126e-01 0.010 0 0
Depyrimidination R-HSA-73928 9.767126e-01 0.010 0 0
Synthesis of PA R-HSA-1483166 9.773332e-01 0.010 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.778314e-01 0.010 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.778603e-01 0.010 0 0
Insulin receptor recycling R-HSA-77387 9.786074e-01 0.009 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.786074e-01 0.009 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.786074e-01 0.009 0 0
Pyrimidine salvage R-HSA-73614 9.786074e-01 0.009 0 0
Pyroptosis R-HSA-5620971 9.786074e-01 0.009 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.788528e-01 0.009 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.795380e-01 0.009 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.796188e-01 0.009 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.808018e-01 0.008 0 0
Amine ligand-binding receptors R-HSA-375280 9.808018e-01 0.008 0 0
Surfactant metabolism R-HSA-5683826 9.808018e-01 0.008 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.808018e-01 0.008 0 0
Glucagon-type ligand receptors R-HSA-420092 9.808971e-01 0.008 0 0
DARPP-32 events R-HSA-180024 9.808971e-01 0.008 0 0
Peroxisomal protein import R-HSA-9033241 9.809513e-01 0.008 0 0
Leishmania infection R-HSA-9658195 9.817206e-01 0.008 0 0
Parasitic Infection Pathways R-HSA-9824443 9.817206e-01 0.008 0 0
tRNA Aminoacylation R-HSA-379724 9.825466e-01 0.008 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.825760e-01 0.008 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.829418e-01 0.007 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.835601e-01 0.007 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.841905e-01 0.007 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.841905e-01 0.007 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.841905e-01 0.007 0 0
Hemostasis R-HSA-109582 9.842911e-01 0.007 0 0
ABC-family proteins mediated transport R-HSA-382556 9.857786e-01 0.006 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.860996e-01 0.006 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.860996e-01 0.006 0 0
Signaling by WNT in cancer R-HSA-4791275 9.863984e-01 0.006 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.863984e-01 0.006 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.863984e-01 0.006 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.863984e-01 0.006 0 0
Neurotransmitter release cycle R-HSA-112310 9.868553e-01 0.006 0 0
Interleukin-10 signaling R-HSA-6783783 9.874396e-01 0.005 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.878545e-01 0.005 0 0
Cardiogenesis R-HSA-9733709 9.878545e-01 0.005 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.882087e-01 0.005 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.884776e-01 0.005 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.887427e-01 0.005 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.890817e-01 0.005 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.890817e-01 0.005 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.890817e-01 0.005 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.891548e-01 0.005 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.891548e-01 0.005 0 0
Heme degradation R-HSA-189483 9.891548e-01 0.005 0 0
Azathioprine ADME R-HSA-9748787 9.893119e-01 0.005 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.893119e-01 0.005 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 9.893535e-01 0.005 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.895871e-01 0.005 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.903141e-01 0.004 0 0
Complex IV assembly R-HSA-9864848 9.903141e-01 0.004 0 0
The phototransduction cascade R-HSA-2514856 9.903141e-01 0.004 0 0
eNOS activation R-HSA-203615 9.903160e-01 0.004 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.903160e-01 0.004 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 9.903160e-01 0.004 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.903160e-01 0.004 0 0
Mitophagy R-HSA-5205647 9.903160e-01 0.004 0 0
RA biosynthesis pathway R-HSA-5365859 9.903160e-01 0.004 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.903160e-01 0.004 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.903712e-01 0.004 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.912243e-01 0.004 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.913529e-01 0.004 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.914283e-01 0.004 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.917742e-01 0.004 0 0
Triglyceride catabolism R-HSA-163560 9.922788e-01 0.003 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.923439e-01 0.003 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.928009e-01 0.003 0 0
Voltage gated Potassium channels R-HSA-1296072 9.931057e-01 0.003 0 0
Degradation of AXIN R-HSA-4641257 9.931057e-01 0.003 0 0
Cleavage of the damaged purine R-HSA-110331 9.931057e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.931057e-01 0.003 0 0
NCAM1 interactions R-HSA-419037 9.931057e-01 0.003 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.931057e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.931057e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.931057e-01 0.003 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.934656e-01 0.003 0 0
ECM proteoglycans R-HSA-3000178 9.934656e-01 0.003 0 0
Hedgehog 'on' state R-HSA-5632684 9.934656e-01 0.003 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.937342e-01 0.003 0 0
Depurination R-HSA-73927 9.938440e-01 0.003 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.938440e-01 0.003 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.938440e-01 0.003 0 0
Regulation of insulin secretion R-HSA-422356 9.940178e-01 0.003 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.944795e-01 0.002 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.945033e-01 0.002 0 0
RAS processing R-HSA-9648002 9.945033e-01 0.002 0 0
Peptide chain elongation R-HSA-156902 9.950141e-01 0.002 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.950529e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.950920e-01 0.002 0 0
Iron uptake and transport R-HSA-917937 9.954658e-01 0.002 0 0
Integration of energy metabolism R-HSA-163685 9.955834e-01 0.002 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.956177e-01 0.002 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.956177e-01 0.002 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 9.956177e-01 0.002 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.956177e-01 0.002 0 0
Triglyceride metabolism R-HSA-8979227 9.956273e-01 0.002 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.957325e-01 0.002 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.960872e-01 0.002 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.960872e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9683701 9.960872e-01 0.002 0 0
Neddylation R-HSA-8951664 9.961089e-01 0.002 0 0
Peptide ligand-binding receptors R-HSA-375276 9.961145e-01 0.002 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.961470e-01 0.002 0 0
Ribosome-associated quality control R-HSA-9948299 9.961727e-01 0.002 0 0
Signaling by Hedgehog R-HSA-5358351 9.961727e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9694635 9.962285e-01 0.002 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.963470e-01 0.002 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.963470e-01 0.002 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.964225e-01 0.002 0 0
Collagen degradation R-HSA-1442490 9.964225e-01 0.002 0 0
Activation of GABAB receptors R-HSA-991365 9.965063e-01 0.002 0 0
GABA B receptor activation R-HSA-977444 9.965063e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.965614e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.965614e-01 0.001 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.965800e-01 0.001 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.967595e-01 0.001 0 0
Defective pyroptosis R-HSA-9710421 9.968806e-01 0.001 0 0
Defensins R-HSA-1461973 9.968806e-01 0.001 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.968806e-01 0.001 0 0
Platelet homeostasis R-HSA-418346 9.971242e-01 0.001 0 0
Proteasome assembly R-HSA-9907900 9.972148e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.972148e-01 0.001 0 0
Amyloid fiber formation R-HSA-977225 9.973976e-01 0.001 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.975132e-01 0.001 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.975132e-01 0.001 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.975132e-01 0.001 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.975132e-01 0.001 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.975132e-01 0.001 0 0
Somitogenesis R-HSA-9824272 9.975132e-01 0.001 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.975629e-01 0.001 0 0
Stimuli-sensing channels R-HSA-2672351 9.975629e-01 0.001 0 0
Eukaryotic Translation Termination R-HSA-72764 9.977143e-01 0.001 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.977797e-01 0.001 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.977797e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.978634e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.980176e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.980488e-01 0.001 0 0
Kidney development R-HSA-9830369 9.980488e-01 0.001 0 0
GPER1 signaling R-HSA-9634597 9.982300e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.982372e-01 0.001 0 0
Regulated Necrosis R-HSA-5218859 9.982372e-01 0.001 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.983711e-01 0.001 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.984197e-01 0.001 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.984197e-01 0.001 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.985619e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.985619e-01 0.001 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.986109e-01 0.001 0 0
Selenocysteine synthesis R-HSA-2408557 9.986551e-01 0.001 0 0
Metal ion assimilation from the host R-HSA-9638482 9.987014e-01 0.001 0 0
Metabolism of cofactors R-HSA-8978934 9.987014e-01 0.001 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.987403e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.987636e-01 0.001 0 0
Viral mRNA Translation R-HSA-192823 9.988749e-01 0.000 0 0
ER-Phagosome pathway R-HSA-1236974 9.988841e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.989415e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.989415e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.989959e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.991376e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.991878e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.992045e-01 0.000 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.992378e-01 0.000 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.992823e-01 0.000 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.992855e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.993073e-01 0.000 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.994305e-01 0.000 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.994807e-01 0.000 0 0
Sialic acid metabolism R-HSA-4085001 9.994915e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.995284e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.995284e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.995461e-01 0.000 0 0
Metabolism of polyamines R-HSA-351202 9.995461e-01 0.000 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.995461e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.995934e-01 0.000 0 0
Aquaporin-mediated transport R-HSA-445717 9.995948e-01 0.000 0 0
Endogenous sterols R-HSA-211976 9.995948e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.995948e-01 0.000 0 0
Protein localization R-HSA-9609507 9.996049e-01 0.000 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.996219e-01 0.000 0 0
Mitochondrial protein import R-HSA-1268020 9.996382e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.997117e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.997119e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.997205e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.997379e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.997503e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.997604e-01 0.000 0 0
Pyruvate metabolism R-HSA-70268 9.997750e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997949e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997949e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.998045e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.998354e-01 0.000 0 0
rRNA processing R-HSA-72312 9.998434e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.998541e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.998582e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998697e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.998837e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.998961e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999010e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999024e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999073e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999145e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999177e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999228e-01 0.000 0 0
ABC transporter disorders R-HSA-5619084 9.999412e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999522e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999563e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999581e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999659e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999702e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999760e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999820e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999820e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999904e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999907e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999925e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999939e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999946e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999957e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999963e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999981e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999988e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999989e-01 0.000 0 0
Disease R-HSA-1643685 9.999990e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999991e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999992e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999995e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999996e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999996e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999997e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999998e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999998e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999999e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999999e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999999e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999999e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Translation R-HSA-72766 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 3.108624e-15 14.507 0 0
HSF1-dependent transactivation R-HSA-3371571 3.086420e-14 13.511 0 0
Cell Cycle R-HSA-1640170 6.572520e-14 13.182 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 1.065814e-13 12.972 0 0
Cellular responses to stimuli R-HSA-8953897 1.005862e-13 12.997 0 0
Attenuation phase R-HSA-3371568 1.344480e-13 12.871 0 0
Cell Cycle, Mitotic R-HSA-69278 7.429612e-13 12.129 0 0
M Phase R-HSA-68886 8.998358e-13 12.046 0 0
Cellular responses to stress R-HSA-2262752 1.018630e-12 11.992 0 0
Metabolism of RNA R-HSA-8953854 2.219447e-12 11.654 0 0
Cell-Cell communication R-HSA-1500931 2.673572e-11 10.573 0 0
HSF1 activation R-HSA-3371511 2.691714e-11 10.570 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.128164e-11 10.384 0 0
mRNA Splicing R-HSA-72172 2.601562e-10 9.585 0 0
Cell junction organization R-HSA-446728 4.605624e-10 9.337 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.422857e-08 7.847 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.691168e-08 7.772 0 0
Mitotic Prophase R-HSA-68875 1.614006e-08 7.792 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 2.944677e-08 7.531 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 2.944677e-08 7.531 0 0
Protein ubiquitination R-HSA-8852135 3.916058e-08 7.407 0 0
Adherens junctions interactions R-HSA-418990 7.987812e-08 7.098 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 8.579524e-08 7.067 0 0
Cell-cell junction organization R-HSA-421270 1.662808e-07 6.779 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.672550e-07 6.777 0 0
G2/M Checkpoints R-HSA-69481 1.942440e-07 6.712 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.256347e-07 6.647 0 0
Signaling by ALK in cancer R-HSA-9700206 2.256347e-07 6.647 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.993518e-07 6.524 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 3.690149e-07 6.433 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.590807e-07 6.338 0 0
Chromatin organization R-HSA-4839726 6.402395e-07 6.194 0 0
Cell Cycle Checkpoints R-HSA-69620 7.968186e-07 6.099 0 0
Chromatin modifying enzymes R-HSA-3247509 1.234426e-06 5.909 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.360290e-06 5.866 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.715716e-06 5.766 0 0
Mitotic Anaphase R-HSA-68882 1.695232e-06 5.771 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.899683e-06 5.721 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.077377e-06 5.682 0 0
DNA Double Strand Break Response R-HSA-5693606 2.946834e-06 5.531 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 3.221252e-06 5.492 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.846031e-06 5.415 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.194603e-06 5.284 0 0
Axon guidance R-HSA-422475 5.731246e-06 5.242 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.106234e-06 5.148 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.018279e-06 5.154 0 0
Nervous system development R-HSA-9675108 7.921510e-06 5.101 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.218695e-06 5.085 0 0
Membrane Trafficking R-HSA-199991 8.484937e-06 5.071 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.153366e-05 4.938 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.207354e-05 4.918 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.208158e-05 4.918 0 0
G2/M Transition R-HSA-69275 1.230565e-05 4.910 0 0
Mitotic Prometaphase R-HSA-68877 1.233732e-05 4.909 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.383095e-05 4.859 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.536086e-05 4.814 0 0
Meiotic synapsis R-HSA-1221632 1.673431e-05 4.776 0 0
Smooth Muscle Contraction R-HSA-445355 1.673431e-05 4.776 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.081522e-05 4.682 0 0
HDACs deacetylate histones R-HSA-3214815 2.575433e-05 4.589 0 0
RNA Polymerase I Transcription R-HSA-73864 2.503040e-05 4.602 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.605337e-05 4.584 0 0
Aggrephagy R-HSA-9646399 2.683226e-05 4.571 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.683226e-05 4.571 0 0
Oncogene Induced Senescence R-HSA-2559585 2.769330e-05 4.558 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.497022e-05 4.456 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.536806e-05 4.451 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 3.641775e-05 4.439 0 0
Regulation of CDH1 Function R-HSA-9764561 3.888913e-05 4.410 0 0
MITF-M-dependent gene expression R-HSA-9856651 4.537716e-05 4.343 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.790740e-05 4.320 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.746549e-05 4.324 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.790740e-05 4.320 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 5.019378e-05 4.299 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.117007e-05 4.291 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.942350e-05 4.226 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 5.942350e-05 4.226 0 0
Striated Muscle Contraction R-HSA-390522 6.244757e-05 4.204 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 6.244757e-05 4.204 0 0
Translation initiation complex formation R-HSA-72649 6.675964e-05 4.175 0 0
DNA Double-Strand Break Repair R-HSA-5693532 6.387136e-05 4.195 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.126749e-05 4.147 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.013533e-05 4.045 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 9.555117e-05 4.020 0 0
Separation of Sister Chromatids R-HSA-2467813 9.836083e-05 4.007 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 9.865643e-05 4.006 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.134975e-04 3.945 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.174994e-04 3.930 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.293161e-04 3.888 0 0
Apoptotic execution phase R-HSA-75153 1.317519e-04 3.880 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.334262e-04 3.875 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.387290e-04 3.858 0 0
mRNA 3'-end processing R-HSA-72187 1.394195e-04 3.856 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.659397e-04 3.780 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.672413e-04 3.777 0 0
Glycolysis R-HSA-70171 1.675411e-04 3.776 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 1.885284e-04 3.725 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.964272e-04 3.707 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 2.003241e-04 3.698 0 0
Signaling by VEGF R-HSA-194138 2.135106e-04 3.671 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.079125e-04 3.682 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.288641e-04 3.640 0 0
PKR-mediated signaling R-HSA-9833482 2.547549e-04 3.594 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.587209e-04 3.587 0 0
Cellular Senescence R-HSA-2559583 2.596438e-04 3.586 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.662133e-04 3.575 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.799050e-04 3.553 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.887277e-04 3.540 0 0
Nuclear import of Rev protein R-HSA-180746 2.887277e-04 3.540 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.138445e-04 3.503 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.198398e-04 3.495 0 0
Macroautophagy R-HSA-1632852 3.294267e-04 3.482 0 0
Cap-dependent Translation Initiation R-HSA-72737 3.320088e-04 3.479 0 0
Eukaryotic Translation Initiation R-HSA-72613 3.320088e-04 3.479 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.357375e-04 3.474 0 0
Interleukin-12 signaling R-HSA-9020591 3.626910e-04 3.440 0 0
Selective autophagy R-HSA-9663891 3.639793e-04 3.439 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 3.992484e-04 3.399 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 3.992484e-04 3.399 0 0
Epigenetic regulation of gene expression R-HSA-212165 4.097780e-04 3.387 0 0
Signaling downstream of RAS mutants R-HSA-9649948 4.099625e-04 3.387 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 4.099625e-04 3.387 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 4.099625e-04 3.387 0 0
Signaling by RAS mutants R-HSA-6802949 4.099625e-04 3.387 0 0
Homology Directed Repair R-HSA-5693538 4.174718e-04 3.379 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.492312e-04 3.348 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.506662e-04 3.346 0 0
Signaling by RAF1 mutants R-HSA-9656223 4.798027e-04 3.319 0 0
Recycling pathway of L1 R-HSA-437239 4.937642e-04 3.306 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.650021e-04 3.333 0 0
Gene Silencing by RNA R-HSA-211000 4.593590e-04 3.338 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 4.798027e-04 3.319 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.995831e-04 3.301 0 0
Deubiquitination R-HSA-5688426 5.002225e-04 3.301 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 5.168494e-04 3.287 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.168494e-04 3.287 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 5.421538e-04 3.266 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.459784e-04 3.263 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.607325e-04 3.251 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.645203e-04 3.248 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.297453e-04 3.201 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 6.297453e-04 3.201 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.794916e-04 3.237 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.403245e-04 3.194 0 0
Muscle contraction R-HSA-397014 6.439986e-04 3.191 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 6.678970e-04 3.175 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.071402e-04 3.150 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 7.268697e-04 3.139 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 7.268697e-04 3.139 0 0
L1CAM interactions R-HSA-373760 7.271457e-04 3.138 0 0
Interleukin-12 family signaling R-HSA-447115 7.665934e-04 3.115 0 0
Autophagy R-HSA-9612973 7.756806e-04 3.110 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.798041e-04 3.108 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.815190e-04 3.107 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.357447e-04 3.078 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 8.704687e-04 3.060 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.357447e-04 3.078 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 8.845214e-04 3.053 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.280595e-04 3.082 0 0
Influenza Infection R-HSA-168255 8.936283e-04 3.049 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 9.626921e-04 3.017 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.006826e-03 2.997 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.009238e-03 2.996 0 0
Nucleosome assembly R-HSA-774815 1.009238e-03 2.996 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.061719e-03 2.974 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.225568e-03 2.912 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.225568e-03 2.912 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.177514e-03 2.929 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.199949e-03 2.921 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.199949e-03 2.921 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.166559e-03 2.933 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.115158e-03 2.953 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.207002e-03 2.918 0 0
Regulation of TP53 Activity R-HSA-5633007 1.111628e-03 2.954 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.231016e-03 2.910 0 0
Meiosis R-HSA-1500620 1.231016e-03 2.910 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 1.136727e-03 2.944 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.199949e-03 2.921 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.207002e-03 2.918 0 0
Programmed Cell Death R-HSA-5357801 1.241137e-03 2.906 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.266685e-03 2.897 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.271698e-03 2.896 0 0
Metabolism of non-coding RNA R-HSA-194441 1.297383e-03 2.887 0 0
snRNP Assembly R-HSA-191859 1.297383e-03 2.887 0 0
Apoptosis R-HSA-109581 1.322815e-03 2.879 0 0
PRC2 methylates histones and DNA R-HSA-212300 1.430612e-03 2.844 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.480790e-03 2.830 0 0
Kinesins R-HSA-983189 1.504092e-03 2.823 0 0
EPH-Ephrin signaling R-HSA-2682334 1.591380e-03 2.798 0 0
HIV Life Cycle R-HSA-162587 1.643053e-03 2.784 0 0
Host Interactions of HIV factors R-HSA-162909 1.655977e-03 2.781 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.695571e-03 2.771 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.697903e-03 2.770 0 0
Glucose metabolism R-HSA-70326 1.699479e-03 2.770 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.720527e-03 2.764 0 0
Post NMDA receptor activation events R-HSA-438064 1.772341e-03 2.751 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.793313e-03 2.746 0 0
HCMV Early Events R-HSA-9609690 1.885789e-03 2.725 0 0
Ub-specific processing proteases R-HSA-5689880 1.907283e-03 2.720 0 0
Diseases of programmed cell death R-HSA-9645723 1.992652e-03 2.701 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.045007e-03 2.689 0 0
Josephin domain DUBs R-HSA-5689877 2.045007e-03 2.689 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.038208e-03 2.691 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 2.297136e-03 2.639 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.322851e-03 2.634 0 0
NRIF signals cell death from the nucleus R-HSA-205043 2.330453e-03 2.633 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.398980e-03 2.620 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.496816e-03 2.603 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 2.802958e-03 2.552 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 2.818926e-03 2.550 0 0
Late endosomal microautophagy R-HSA-9615710 2.920452e-03 2.535 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.920452e-03 2.535 0 0
PECAM1 interactions R-HSA-210990 2.939396e-03 2.532 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 3.130651e-03 2.504 0 0
Signaling by ROBO receptors R-HSA-376176 3.139898e-03 2.503 0 0
Vesicle-mediated transport R-HSA-5653656 3.148987e-03 2.502 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 3.386951e-03 2.470 0 0
Regulation of PTEN localization R-HSA-8948747 3.401924e-03 2.468 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.411119e-03 2.467 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 3.458791e-03 2.461 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.486871e-03 2.458 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.551507e-03 2.450 0 0
SARS-CoV-2-host interactions R-HSA-9705683 3.617010e-03 2.442 0 0
Nephrin family interactions R-HSA-373753 3.823018e-03 2.418 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.050639e-03 2.392 0 0
NF-kB is activated and signals survival R-HSA-209560 4.097982e-03 2.387 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.097982e-03 2.387 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.097982e-03 2.387 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 4.809516e-03 2.318 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 4.809516e-03 2.318 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 4.742016e-03 2.324 0 0
Centrosome maturation R-HSA-380287 4.417207e-03 2.355 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 4.854004e-03 2.314 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.226804e-03 2.374 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 4.473248e-03 2.349 0 0
Platelet degranulation R-HSA-114608 4.699310e-03 2.328 0 0
rRNA processing R-HSA-72312 4.672391e-03 2.330 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.824064e-03 2.317 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 4.991783e-03 2.302 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.991783e-03 2.302 0 0
Formation of annular gap junctions R-HSA-196025 5.059761e-03 2.296 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.059761e-03 2.296 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.072999e-03 2.295 0 0
Degradation of CDH1 R-HSA-9766229 5.111777e-03 2.291 0 0
Gap junction trafficking and regulation R-HSA-157858 5.111777e-03 2.291 0 0
Interferon Signaling R-HSA-913531 5.253827e-03 2.280 0 0
Disorders of Developmental Biology R-HSA-9675151 5.342499e-03 2.272 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.342499e-03 2.272 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.342499e-03 2.272 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.370016e-03 2.270 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.497317e-03 2.260 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.497317e-03 2.260 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.563575e-03 2.255 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.563575e-03 2.255 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.563575e-03 2.255 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.773369e-03 2.239 0 0
Late Phase of HIV Life Cycle R-HSA-162599 5.853811e-03 2.233 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 5.980129e-03 2.223 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 5.980129e-03 2.223 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.111550e-03 2.214 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 6.111550e-03 2.214 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 6.111550e-03 2.214 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.182156e-03 2.209 0 0
Packaging Of Telomere Ends R-HSA-171306 6.186713e-03 2.209 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 6.186713e-03 2.209 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 6.186713e-03 2.209 0 0
Estrogen-dependent gene expression R-HSA-9018519 6.197208e-03 2.208 0 0
Gap junction degradation R-HSA-190873 7.221246e-03 2.141 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 7.379367e-03 2.132 0 0
mTORC1-mediated signalling R-HSA-166208 7.355444e-03 2.133 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 7.435071e-03 2.129 0 0
Stabilization of p53 R-HSA-69541 6.848054e-03 2.164 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 6.475886e-03 2.189 0 0
TCF dependent signaling in response to WNT R-HSA-201681 7.070625e-03 2.151 0 0
DNA Replication R-HSA-69306 7.449587e-03 2.128 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 6.848054e-03 2.164 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 6.810729e-03 2.167 0 0
Signal Transduction R-HSA-162582 7.297294e-03 2.137 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.350967e-03 2.134 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 7.379367e-03 2.132 0 0
Gap junction trafficking R-HSA-190828 6.379702e-03 2.195 0 0
SARS-CoV Infections R-HSA-9679506 7.163207e-03 2.145 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.502241e-03 2.125 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.570146e-03 2.121 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 7.570146e-03 2.121 0 0
HATs acetylate histones R-HSA-3214847 7.672090e-03 2.115 0 0
PTEN Regulation R-HSA-6807070 7.824202e-03 2.107 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.958774e-03 2.099 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.346435e-03 2.078 0 0
HCMV Infection R-HSA-9609646 8.370957e-03 2.077 0 0
DNA Repair R-HSA-73894 8.519197e-03 2.070 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 8.559007e-03 2.068 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.559007e-03 2.068 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.559007e-03 2.068 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 8.567512e-03 2.067 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 8.567512e-03 2.067 0 0
Maturation of protein E R-HSA-9694493 8.567512e-03 2.067 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 8.567512e-03 2.067 0 0
Maturation of protein E R-HSA-9683683 8.567512e-03 2.067 0 0
Signaling by ERBB2 R-HSA-1227986 8.810559e-03 2.055 0 0
DNA methylation R-HSA-5334118 8.867059e-03 2.052 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.867059e-03 2.052 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 9.204574e-03 2.036 0 0
HIV Infection R-HSA-162906 9.282357e-03 2.032 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.902008e-03 2.004 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 9.955448e-03 2.002 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 9.955448e-03 2.002 0 0
Pexophagy R-HSA-9664873 9.955448e-03 2.002 0 0
Regulation of signaling by CBL R-HSA-912631 1.061623e-02 1.974 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.301084e-02 1.886 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.080392e-02 1.966 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.080392e-02 1.966 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 1.234600e-02 1.908 0 0
MAP2K and MAPK activation R-HSA-5674135 1.059569e-02 1.975 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 1.059569e-02 1.975 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 1.059569e-02 1.975 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.094241e-02 1.961 0 0
Ca-dependent events R-HSA-111996 1.214249e-02 1.916 0 0
p75NTR signals via NF-kB R-HSA-193639 1.223139e-02 1.913 0 0
CaM pathway R-HSA-111997 1.152528e-02 1.938 0 0
Calmodulin induced events R-HSA-111933 1.152528e-02 1.938 0 0
Translesion Synthesis by POLH R-HSA-110320 1.061623e-02 1.974 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.112180e-02 1.954 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.059569e-02 1.975 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.193832e-02 1.923 0 0
Signaling by EGFR R-HSA-177929 1.251126e-02 1.903 0 0
Signaling by WNT R-HSA-195721 1.149958e-02 1.939 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 1.216244e-02 1.915 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.193832e-02 1.923 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 1.223139e-02 1.913 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.223139e-02 1.913 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.223139e-02 1.913 0 0
Negative regulation of MET activity R-HSA-6807004 1.301084e-02 1.886 0 0
Rap1 signalling R-HSA-392517 1.061623e-02 1.974 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.202633e-02 1.920 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.223139e-02 1.913 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.256969e-02 1.901 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.052382e-02 1.978 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.134628e-02 1.945 0 0
Potential therapeutics for SARS R-HSA-9679191 1.058205e-02 1.975 0 0
tRNA processing in the nucleus R-HSA-6784531 1.109681e-02 1.955 0 0
Interleukin-37 signaling R-HSA-9008059 1.049868e-02 1.979 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.202633e-02 1.920 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.321153e-02 1.879 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.331917e-02 1.876 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.375881e-02 1.861 0 0
Defective pyroptosis R-HSA-9710421 1.385538e-02 1.858 0 0
Protein folding R-HSA-391251 1.442147e-02 1.841 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.442499e-02 1.841 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.491043e-02 1.827 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.491910e-02 1.826 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.532224e-02 1.815 0 0
Myogenesis R-HSA-525793 1.532224e-02 1.815 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 1.534877e-02 1.814 0 0
S Phase R-HSA-69242 1.594477e-02 1.797 0 0
Hedgehog 'off' state R-HSA-5610787 1.620240e-02 1.790 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.668012e-02 1.778 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.675145e-02 1.776 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.698366e-02 1.770 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.698366e-02 1.770 0 0
Amyloid fiber formation R-HSA-977225 1.736289e-02 1.760 0 0
Developmental Biology R-HSA-1266738 1.746984e-02 1.758 0 0
Orc1 removal from chromatin R-HSA-68949 1.777628e-02 1.750 0 0
DAG and IP3 signaling R-HSA-1489509 1.782094e-02 1.749 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.794810e-02 1.746 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.796594e-02 1.746 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.892145e-02 1.723 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.892145e-02 1.723 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.901514e-02 1.721 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.944448e-02 1.711 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.992905e-02 1.701 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.996063e-02 1.700 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.022724e-02 1.694 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 2.107248e-02 1.676 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.144129e-02 1.669 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.220585e-02 1.654 0 0
Disorders of Nervous System Development R-HSA-9697154 2.220585e-02 1.654 0 0
Pervasive developmental disorders R-HSA-9005895 2.220585e-02 1.654 0 0
Dual Incision in GG-NER R-HSA-5696400 2.220797e-02 1.653 0 0
Mitophagy R-HSA-5205647 2.220797e-02 1.653 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 2.220797e-02 1.653 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 2.248877e-02 1.648 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.263551e-02 1.645 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.267723e-02 1.644 0 0
Signaling by Hippo R-HSA-2028269 2.315077e-02 1.635 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.373170e-02 1.625 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.438886e-02 1.613 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 2.438886e-02 1.613 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.438886e-02 1.613 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 2.438886e-02 1.613 0 0
Modulation by Mtb of host immune system R-HSA-9637628 2.438886e-02 1.613 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.789944e-02 1.554 0 0
Ephrin signaling R-HSA-3928664 2.789944e-02 1.554 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 2.649547e-02 1.577 0 0
EGFR downregulation R-HSA-182971 3.233170e-02 1.490 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 3.233170e-02 1.490 0 0
Chaperonin-mediated protein folding R-HSA-390466 3.156659e-02 1.501 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.536735e-02 1.596 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.203676e-02 1.494 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.819454e-02 1.550 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.819454e-02 1.550 0 0
Developmental Cell Lineages R-HSA-9734767 2.517010e-02 1.599 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 2.629361e-02 1.580 0 0
Syndecan interactions R-HSA-3000170 2.649547e-02 1.577 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.261636e-02 1.487 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.527136e-02 1.597 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 3.233170e-02 1.490 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.699633e-02 1.569 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.203676e-02 1.494 0 0
Ion homeostasis R-HSA-5578775 2.733921e-02 1.563 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.203676e-02 1.494 0 0
Unwinding of DNA R-HSA-176974 3.203676e-02 1.494 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.780749e-02 1.556 0 0
HCMV Late Events R-HSA-9610379 2.799423e-02 1.553 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.203676e-02 1.494 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 2.819454e-02 1.550 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.874730e-02 1.541 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.649547e-02 1.577 0 0
Semaphorin interactions R-HSA-373755 2.629361e-02 1.580 0 0
Cleavage of the damaged purine R-HSA-110331 3.261636e-02 1.487 0 0
Signaling by Interleukins R-HSA-449147 3.087316e-02 1.510 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.273148e-02 1.485 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.286652e-02 1.483 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.324944e-02 1.478 0 0
MHC class II antigen presentation R-HSA-2132295 3.392761e-02 1.469 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.423233e-02 1.466 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.423233e-02 1.466 0 0
Meiotic recombination R-HSA-912446 3.475520e-02 1.459 0 0
Reproduction R-HSA-1474165 3.569784e-02 1.447 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.583920e-02 1.446 0 0
Long-term potentiation R-HSA-9620244 3.590863e-02 1.445 0 0
Depurination R-HSA-73927 3.673064e-02 1.435 0 0
ESR-mediated signaling R-HSA-8939211 3.731374e-02 1.428 0 0
Ribosome-associated quality control R-HSA-9948299 3.732525e-02 1.428 0 0
Death Receptor Signaling R-HSA-73887 3.801505e-02 1.420 0 0
Formation of definitive endoderm R-HSA-9823730 3.922256e-02 1.406 0 0
Fanconi Anemia Pathway R-HSA-6783310 3.997904e-02 1.398 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.997904e-02 1.398 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.997904e-02 1.398 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.093865e-02 1.388 0 0
Regulation of CDH11 function R-HSA-9762292 4.093865e-02 1.388 0 0
Plasma lipoprotein clearance R-HSA-8964043 4.118617e-02 1.385 0 0
Metalloprotease DUBs R-HSA-5689901 4.134989e-02 1.384 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 4.150565e-02 1.382 0 0
Translesion synthesis by REV1 R-HSA-110312 4.150565e-02 1.382 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 4.150565e-02 1.382 0 0
Protein methylation R-HSA-8876725 4.150565e-02 1.382 0 0
Spry regulation of FGF signaling R-HSA-1295596 4.150565e-02 1.382 0 0
Activation of ATR in response to replication stress R-HSA-176187 4.177867e-02 1.379 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.208595e-02 1.376 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.208595e-02 1.376 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.232310e-02 1.373 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 4.278661e-02 1.369 0 0
Regulation of TNFR1 signaling R-HSA-5357905 4.431110e-02 1.353 0 0
Nucleotide Excision Repair R-HSA-5696398 4.540928e-02 1.343 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 4.551988e-02 1.342 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 4.583603e-02 1.339 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 4.599263e-02 1.337 0 0
Interaction between L1 and Ankyrins R-HSA-445095 4.729976e-02 1.325 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 4.729976e-02 1.325 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.729976e-02 1.325 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 4.797461e-02 1.319 0 0
Neutrophil degranulation R-HSA-6798695 4.835075e-02 1.316 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 4.895070e-02 1.310 0 0
PCP/CE pathway R-HSA-4086400 4.936047e-02 1.307 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.949208e-02 1.305 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.949208e-02 1.305 0 0
Translesion synthesis by POLI R-HSA-5656121 4.964379e-02 1.304 0 0
Negative regulation of FLT3 R-HSA-9706369 4.964379e-02 1.304 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.002177e-02 1.301 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 5.110279e-02 1.292 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 5.110279e-02 1.292 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 5.115848e-02 1.291 0 0
RAF activation R-HSA-5673000 5.289439e-02 1.277 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.289439e-02 1.277 0 0
Calnexin/calreticulin cycle R-HSA-901042 5.289439e-02 1.277 0 0
Signaling by PDGFR in disease R-HSA-9671555 5.310237e-02 1.275 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.310237e-02 1.275 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 5.310237e-02 1.275 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.375506e-02 1.270 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.388750e-02 1.269 0 0
Interleukin-1 family signaling R-HSA-446652 5.388750e-02 1.269 0 0
NRAGE signals death through JNK R-HSA-193648 5.568776e-02 1.254 0 0
Signaling by FGFR1 in disease R-HSA-5655302 5.669092e-02 1.246 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.669092e-02 1.246 0 0
Ion transport by P-type ATPases R-HSA-936837 5.674513e-02 1.246 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.828487e-02 1.234 0 0
Translesion synthesis by POLK R-HSA-5655862 5.865420e-02 1.232 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 5.865420e-02 1.232 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 5.910039e-02 1.228 0 0
Regulation of Apoptosis R-HSA-169911 5.910039e-02 1.228 0 0
DNA Damage Bypass R-HSA-73893 5.917863e-02 1.228 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.978890e-02 1.223 0 0
Regulation of TP53 Expression R-HSA-6804754 5.978890e-02 1.223 0 0
Diseases of Cellular Senescence R-HSA-9630747 5.978890e-02 1.223 0 0
Diseases of cellular response to stress R-HSA-9675132 5.978890e-02 1.223 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.978890e-02 1.223 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 5.978890e-02 1.223 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 5.978890e-02 1.223 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.978890e-02 1.223 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.978890e-02 1.223 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.978890e-02 1.223 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.978890e-02 1.223 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.978890e-02 1.223 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.978890e-02 1.223 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.978890e-02 1.223 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.978890e-02 1.223 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.978890e-02 1.223 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 5.978890e-02 1.223 0 0
MET interacts with TNS proteins R-HSA-8875513 8.771395e-02 1.057 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 8.771395e-02 1.057 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 8.771395e-02 1.057 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 8.771395e-02 1.057 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 6.040800e-02 1.219 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 7.726477e-02 1.112 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.726477e-02 1.112 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 7.515766e-02 1.124 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.897779e-02 1.051 0 0
PKA activation R-HSA-163615 7.927938e-02 1.101 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.076510e-02 1.216 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.355775e-02 1.078 0 0
UCH proteinases R-HSA-5689603 7.675156e-02 1.115 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.454407e-02 1.190 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.947122e-02 1.100 0 0
TGFBR3 expression R-HSA-9839394 8.878127e-02 1.052 0 0
G alpha (12/13) signalling events R-HSA-416482 8.792975e-02 1.056 0 0
Chromosome Maintenance R-HSA-73886 8.065816e-02 1.093 0 0
PLC beta mediated events R-HSA-112043 8.366796e-02 1.077 0 0
Eukaryotic Translation Elongation R-HSA-156842 8.454513e-02 1.073 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 8.897779e-02 1.051 0 0
Trafficking of AMPA receptors R-HSA-399719 7.635513e-02 1.117 0 0
Budding and maturation of HIV virion R-HSA-162588 7.635513e-02 1.117 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.749533e-02 1.171 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.040800e-02 1.219 0 0
Degradation of DVL R-HSA-4641258 7.283675e-02 1.138 0 0
Mitotic Spindle Checkpoint R-HSA-69618 8.760041e-02 1.057 0 0
Regulation of PTEN stability and activity R-HSA-8948751 8.355775e-02 1.078 0 0
MTOR signalling R-HSA-165159 6.259581e-02 1.203 0 0
CHL1 interactions R-HSA-447041 7.726477e-02 1.112 0 0
Co-inhibition by PD-1 R-HSA-389948 7.050652e-02 1.152 0 0
Gene expression (Transcription) R-HSA-74160 6.727746e-02 1.172 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.258313e-02 1.083 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 8.771395e-02 1.057 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 6.251841e-02 1.204 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.853581e-02 1.164 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.459899e-02 1.127 0 0
MAPK family signaling cascades R-HSA-5683057 8.209931e-02 1.086 0 0
Signaling by TGFB family members R-HSA-9006936 7.991859e-02 1.097 0 0
Cilium Assembly R-HSA-5617833 6.681665e-02 1.175 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.635513e-02 1.117 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.146277e-02 1.211 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 7.726477e-02 1.112 0 0
Sema4D in semaphorin signaling R-HSA-400685 8.878127e-02 1.052 0 0
RET signaling R-HSA-8853659 6.574663e-02 1.182 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 7.887268e-02 1.103 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 7.635513e-02 1.117 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.515766e-02 1.124 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.515766e-02 1.124 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 6.102935e-02 1.214 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 7.887268e-02 1.103 0 0
Neurodegenerative Diseases R-HSA-8863678 7.887268e-02 1.103 0 0
Organelle biogenesis and maintenance R-HSA-1852241 8.312044e-02 1.080 0 0
Viral Infection Pathways R-HSA-9824446 6.629478e-02 1.179 0 0
IRAK1 recruits IKK complex R-HSA-937039 7.515766e-02 1.124 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 7.515766e-02 1.124 0 0
FLT3 signaling in disease R-HSA-9682385 6.574663e-02 1.182 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.320418e-02 1.199 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.259581e-02 1.203 0 0
Depyrimidination R-HSA-73928 6.259581e-02 1.203 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.923918e-02 1.049 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.000868e-02 1.046 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 9.000868e-02 1.046 0 0
Signaling by TGFBR3 R-HSA-9839373 9.000868e-02 1.046 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 9.086809e-02 1.042 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.086809e-02 1.042 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.193468e-02 1.037 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 9.368633e-02 1.028 0 0
PDGFR mutants bind TKIs R-HSA-9674428 9.368633e-02 1.028 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 9.368633e-02 1.028 0 0
Defective translocation of RB1 mutants to the nucleus R-HSA-9661070 9.368633e-02 1.028 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 9.368633e-02 1.028 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 9.368633e-02 1.028 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 9.368633e-02 1.028 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 9.368633e-02 1.028 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 9.368633e-02 1.028 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 9.368633e-02 1.028 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 9.368633e-02 1.028 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 9.368633e-02 1.028 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 9.407367e-02 1.027 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 9.407367e-02 1.027 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.407367e-02 1.027 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.558061e-02 1.020 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 9.593022e-02 1.018 0 0
Type I hemidesmosome assembly R-HSA-446107 9.593022e-02 1.018 0 0
Interleukin-18 signaling R-HSA-9012546 9.593022e-02 1.018 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 9.593022e-02 1.018 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 9.593022e-02 1.018 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 9.593022e-02 1.018 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 9.677737e-02 1.014 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 9.677737e-02 1.014 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 9.677737e-02 1.014 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.828095e-02 1.008 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 1.000739e-01 1.000 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.021883e-01 0.991 0 0
Signal transduction by L1 R-HSA-445144 1.032781e-01 0.986 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 1.032781e-01 0.986 0 0
Vpu mediated degradation of CD4 R-HSA-180534 1.037198e-01 0.984 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.039233e-01 0.983 0 0
HDL assembly R-HSA-8963896 1.039233e-01 0.983 0 0
Regulation of KIT signaling R-HSA-1433559 1.039233e-01 0.983 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.039233e-01 0.983 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.039233e-01 0.983 0 0
Non-canonical inflammasome activation R-HSA-9686114 1.039233e-01 0.983 0 0
TNF signaling R-HSA-75893 1.053374e-01 0.977 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.056401e-01 0.976 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.056401e-01 0.976 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.056401e-01 0.976 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.105203e-01 0.957 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.105203e-01 0.957 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.118905e-01 0.951 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.138790e-01 0.944 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.138790e-01 0.944 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 1.138790e-01 0.944 0 0
Gap junction assembly R-HSA-190861 1.138790e-01 0.944 0 0
Degradation of CRY and PER proteins R-HSA-9932298 1.149356e-01 0.940 0 0
Signaling by NOTCH4 R-HSA-9013694 1.161987e-01 0.935 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.162253e-01 0.935 0 0
ALK mutants bind TKIs R-HSA-9700645 1.162253e-01 0.935 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.162253e-01 0.935 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 1.162253e-01 0.935 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.164793e-01 0.934 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.164793e-01 0.934 0 0
Basigin interactions R-HSA-210991 1.164793e-01 0.934 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.186602e-01 0.926 0 0
NADE modulates death signalling R-HSA-205025 1.186602e-01 0.926 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.186602e-01 0.926 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.186602e-01 0.926 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.199279e-01 0.921 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.199279e-01 0.921 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.204562e-01 0.919 0 0
Signaling by NOTCH R-HSA-157118 1.207586e-01 0.918 0 0
Dual incision in TC-NER R-HSA-6782135 1.215074e-01 0.915 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.223179e-01 0.913 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.232385e-01 0.909 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.235976e-01 0.908 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 1.245395e-01 0.905 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.245395e-01 0.905 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 1.269607e-01 0.896 0 0
G-protein mediated events R-HSA-112040 1.269607e-01 0.896 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.304358e-01 0.885 0 0
Synthesis of DNA R-HSA-69239 1.342529e-01 0.872 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.347062e-01 0.871 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.347062e-01 0.871 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 1.347913e-01 0.870 0 0
Signaling by FGFR4 R-HSA-5654743 1.347913e-01 0.870 0 0
Regulated Necrosis R-HSA-5218859 1.351909e-01 0.869 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.356869e-01 0.867 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 1.369170e-01 0.864 0 0
Prolonged ERK activation events R-HSA-169893 1.369170e-01 0.864 0 0
Regulation of BACH1 activity R-HSA-9708530 1.369170e-01 0.864 0 0
Signaling by Hedgehog R-HSA-5358351 1.379141e-01 0.860 0 0
2-LTR circle formation R-HSA-164843 1.379599e-01 0.860 0 0
CASP4 inflammasome assembly R-HSA-9948001 1.379599e-01 0.860 0 0
Antigen processing-Cross presentation R-HSA-1236975 1.409247e-01 0.851 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.424196e-01 0.846 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.424196e-01 0.846 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.786005e-01 0.748 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.786005e-01 0.748 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.786005e-01 0.748 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.786005e-01 0.748 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.786005e-01 0.748 0 0
TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3642279 1.786005e-01 0.748 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.786005e-01 0.748 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.786005e-01 0.748 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.786005e-01 0.748 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.786005e-01 0.748 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.786005e-01 0.748 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.555635e-01 0.593 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.555635e-01 0.593 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 2.555635e-01 0.593 0 0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) R-HSA-5619111 2.555635e-01 0.593 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.555635e-01 0.593 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.555635e-01 0.593 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.555635e-01 0.593 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.555635e-01 0.593 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.555635e-01 0.593 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.518174e-01 0.819 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.518174e-01 0.819 0 0
IRS activation R-HSA-74713 1.518174e-01 0.819 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.518174e-01 0.819 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.518174e-01 0.819 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 1.865001e-01 0.729 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.865001e-01 0.729 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.865001e-01 0.729 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.221320e-01 0.653 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.582312e-01 0.588 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.582312e-01 0.588 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.582312e-01 0.588 0 0
IFNG signaling activates MAPKs R-HSA-9732724 2.582312e-01 0.588 0 0
Recycling of eIF2:GDP R-HSA-72731 2.582312e-01 0.588 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.098565e-01 0.678 0 0
Scavenging by Class F Receptors R-HSA-3000484 2.098565e-01 0.678 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.735181e-01 0.761 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.735181e-01 0.761 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 2.354205e-01 0.628 0 0
Retrograde neurotrophin signalling R-HSA-177504 2.614858e-01 0.583 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.878887e-01 0.541 0 0
G beta:gamma signalling through BTK R-HSA-8964315 2.878887e-01 0.541 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.099929e-01 0.678 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.547134e-01 0.594 0 0
Cristae formation R-HSA-8949613 2.275051e-01 0.643 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.761475e-01 0.559 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.524088e-01 0.817 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 1.792360e-01 0.747 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.843385e-01 0.734 0 0
Peptide chain elongation R-HSA-156902 1.664654e-01 0.779 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.599483e-01 0.796 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.423647e-01 0.616 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.558099e-01 0.592 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.845034e-01 0.546 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 2.833500e-01 0.548 0 0
Post-translational protein phosphorylation R-HSA-8957275 2.808368e-01 0.552 0 0
Signaling by NOTCH2 R-HSA-1980145 2.198598e-01 0.658 0 0
Integrin cell surface interactions R-HSA-216083 2.317352e-01 0.635 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.550328e-01 0.593 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.550328e-01 0.593 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.822594e-01 0.549 0 0
Activation of the pre-replicative complex R-HSA-68962 1.476603e-01 0.831 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.099929e-01 0.678 0 0
Integration of provirus R-HSA-162592 1.849682e-01 0.733 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.451070e-01 0.838 0 0
Frs2-mediated activation R-HSA-170968 2.354205e-01 0.628 0 0
Insulin receptor recycling R-HSA-77387 2.454242e-01 0.610 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.518174e-01 0.819 0 0
DNA strand elongation R-HSA-69190 1.751516e-01 0.757 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.423647e-01 0.616 0 0
Eukaryotic Translation Termination R-HSA-72764 2.499953e-01 0.602 0 0
Protein localization R-HSA-9609507 2.483205e-01 0.605 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.558179e-01 0.592 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.562609e-01 0.806 0 0
Telomere Maintenance R-HSA-157579 1.844212e-01 0.734 0 0
Reelin signalling pathway R-HSA-8866376 1.518174e-01 0.819 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.098565e-01 0.678 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 2.354205e-01 0.628 0 0
ER-Phagosome pathway R-HSA-1236974 1.749711e-01 0.757 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.767017e-01 0.753 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.767017e-01 0.753 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.636942e-01 0.579 0 0
Cellular response to starvation R-HSA-9711097 2.156389e-01 0.666 0 0
Translation R-HSA-72766 1.701663e-01 0.769 0 0
DAP12 signaling R-HSA-2424491 2.822594e-01 0.549 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.902279e-01 0.721 0 0
GPVI-mediated activation cascade R-HSA-114604 2.515634e-01 0.599 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.518174e-01 0.819 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 1.865001e-01 0.729 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 1.865001e-01 0.729 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.614858e-01 0.583 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.792360e-01 0.747 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.098565e-01 0.678 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.822594e-01 0.549 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 1.865001e-01 0.729 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.929543e-01 0.715 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 2.099929e-01 0.678 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 2.547482e-01 0.594 0 0
Signaling by FGFR2 R-HSA-5654738 2.537013e-01 0.596 0 0
Intraflagellar transport R-HSA-5620924 1.912482e-01 0.718 0 0
Neurofascin interactions R-HSA-447043 2.221320e-01 0.653 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.896258e-01 0.722 0 0
Signaling by FGFR in disease R-HSA-1226099 1.902279e-01 0.721 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 2.148096e-01 0.668 0 0
Signaling by FGFR3 R-HSA-5654741 1.562609e-01 0.806 0 0
Cyclin D associated events in G1 R-HSA-69231 1.453306e-01 0.838 0 0
G1 Phase R-HSA-69236 1.453306e-01 0.838 0 0
TCR signaling R-HSA-202403 2.273534e-01 0.643 0 0
Inhibition of PKR R-HSA-169131 1.786005e-01 0.748 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.555635e-01 0.593 0 0
VEGF ligand-receptor interactions R-HSA-194313 1.865001e-01 0.729 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 1.865001e-01 0.729 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 2.582312e-01 0.588 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 2.582312e-01 0.588 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 2.354205e-01 0.628 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 2.354205e-01 0.628 0 0
Degradation of AXIN R-HSA-4641257 1.473049e-01 0.832 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.473049e-01 0.832 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.562609e-01 0.806 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.627327e-01 0.789 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.896258e-01 0.722 0 0
Biotin transport and metabolism R-HSA-196780 2.878887e-01 0.541 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.547134e-01 0.594 0 0
Circadian clock R-HSA-9909396 1.497320e-01 0.825 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.793495e-01 0.554 0 0
PERK regulates gene expression R-HSA-381042 2.355467e-01 0.628 0 0
Signaling by MET R-HSA-6806834 2.537013e-01 0.596 0 0
The NLRP3 inflammasome R-HSA-844456 2.130266e-01 0.672 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.718763e-01 0.765 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.198598e-01 0.658 0 0
RMTs methylate histone arginines R-HSA-3214858 1.453306e-01 0.838 0 0
Protein hydroxylation R-HSA-9629569 2.336433e-01 0.631 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.896258e-01 0.722 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 2.099929e-01 0.678 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.844324e-01 0.546 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.751516e-01 0.757 0 0
Activation of BH3-only proteins R-HSA-114452 1.476603e-01 0.831 0 0
Immune System R-HSA-168256 2.788774e-01 0.555 0 0
G1/S Transition R-HSA-69206 1.559494e-01 0.807 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.524851e-01 0.817 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.518174e-01 0.819 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.865001e-01 0.729 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.221320e-01 0.653 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.130266e-01 0.672 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.547134e-01 0.594 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.980839e-01 0.703 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.678715e-01 0.572 0 0
Iron uptake and transport R-HSA-917937 2.002751e-01 0.698 0 0
Cellular response to chemical stress R-HSA-9711123 1.628898e-01 0.788 0 0
Ion channel transport R-HSA-983712 1.821866e-01 0.739 0 0
Hedgehog 'on' state R-HSA-5632684 2.550328e-01 0.593 0 0
Gluconeogenesis R-HSA-70263 1.912482e-01 0.718 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 2.546147e-01 0.594 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.291651e-01 0.640 0 0
Signaling by ALK R-HSA-201556 1.718763e-01 0.765 0 0
Assembly Of The HIV Virion R-HSA-175474 2.761475e-01 0.559 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.609392e-01 0.793 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 2.275051e-01 0.643 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.615373e-01 0.792 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.548092e-01 0.810 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 2.761475e-01 0.559 0 0
Signaling by NOTCH3 R-HSA-9012852 2.833500e-01 0.548 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 2.110235e-01 0.676 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.547134e-01 0.594 0 0
Pyroptosis R-HSA-5620971 2.454242e-01 0.610 0 0
Base Excision Repair R-HSA-73884 2.734529e-01 0.563 0 0
Inositol phosphate metabolism R-HSA-1483249 1.694055e-01 0.771 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.547134e-01 0.594 0 0
Glycogen storage diseases R-HSA-3229121 1.735181e-01 0.761 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.627327e-01 0.789 0 0
Glycogen synthesis R-HSA-3322077 2.336433e-01 0.631 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.518174e-01 0.819 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 1.929543e-01 0.715 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 2.943977e-01 0.531 0 0
Cellular response to hypoxia R-HSA-1234174 2.945146e-01 0.531 0 0
IRE1alpha activates chaperones R-HSA-381070 2.954810e-01 0.529 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.974004e-01 0.527 0 0
Signaling by FGFR1 R-HSA-5654736 2.974004e-01 0.527 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.974004e-01 0.527 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.974004e-01 0.527 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.974004e-01 0.527 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.978587e-01 0.526 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.978587e-01 0.526 0 0
LDL clearance R-HSA-8964038 2.978587e-01 0.526 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 2.978587e-01 0.526 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.997543e-01 0.523 0 0
Molecules associated with elastic fibres R-HSA-2129379 3.010646e-01 0.521 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.012074e-01 0.521 0 0
RAS processing R-HSA-9648002 3.012074e-01 0.521 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.012074e-01 0.521 0 0
ABC-family proteins mediated transport R-HSA-382556 3.020344e-01 0.520 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 3.144775e-01 0.502 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.144775e-01 0.502 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.144775e-01 0.502 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 3.144775e-01 0.502 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 3.144775e-01 0.502 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 3.144775e-01 0.502 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 3.144775e-01 0.502 0 0
Generation of second messenger molecules R-HSA-202433 3.181582e-01 0.497 0 0
Glycogen metabolism R-HSA-8982491 3.181582e-01 0.497 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 3.197635e-01 0.495 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 3.253194e-01 0.488 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.253194e-01 0.488 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.253194e-01 0.488 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.253194e-01 0.488 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 3.259501e-01 0.487 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.303022e-01 0.481 0 0
ARMS-mediated activation R-HSA-170984 3.303022e-01 0.481 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.303022e-01 0.481 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 3.303022e-01 0.481 0 0
WNT mediated activation of DVL R-HSA-201688 3.303022e-01 0.481 0 0
Calcineurin activates NFAT R-HSA-2025928 3.303022e-01 0.481 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 3.303022e-01 0.481 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.303022e-01 0.481 0 0
Interleukin-1 processing R-HSA-448706 3.303022e-01 0.481 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.303022e-01 0.481 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 3.303022e-01 0.481 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.303022e-01 0.481 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 3.303022e-01 0.481 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.303022e-01 0.481 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 3.303022e-01 0.481 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 3.307256e-01 0.481 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.345520e-01 0.476 0 0
FLT3 Signaling R-HSA-9607240 3.352471e-01 0.475 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.353580e-01 0.474 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.371740e-01 0.472 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.387509e-01 0.470 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.404044e-01 0.468 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.407764e-01 0.468 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.408760e-01 0.467 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 3.411125e-01 0.467 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.411125e-01 0.467 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 3.411125e-01 0.467 0 0
Synthesis of PG R-HSA-1483148 3.411125e-01 0.467 0 0
ABC transporter disorders R-HSA-5619084 3.415905e-01 0.466 0 0
Deadenylation of mRNA R-HSA-429947 3.417819e-01 0.466 0 0
Complex III assembly R-HSA-9865881 3.417819e-01 0.466 0 0
Plasma lipoprotein assembly R-HSA-8963898 3.417819e-01 0.466 0 0
RNA Polymerase II Transcription R-HSA-73857 3.445562e-01 0.463 0 0
Opioid Signalling R-HSA-111885 3.456218e-01 0.461 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.463890e-01 0.460 0 0
Translation of Structural Proteins R-HSA-9683701 3.524368e-01 0.453 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.583862e-01 0.446 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 3.583862e-01 0.446 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.617465e-01 0.442 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 3.621335e-01 0.441 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.621335e-01 0.441 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.638381e-01 0.439 0 0
Tight junction interactions R-HSA-420029 3.638381e-01 0.439 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.638381e-01 0.439 0 0
Laminin interactions R-HSA-3000157 3.638381e-01 0.439 0 0
Interleukin-7 signaling R-HSA-1266695 3.638381e-01 0.439 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 3.656765e-01 0.437 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 3.656765e-01 0.437 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 3.656765e-01 0.437 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.656765e-01 0.437 0 0
Formation of intermediate mesoderm R-HSA-9761174 3.656765e-01 0.437 0 0
Signal attenuation R-HSA-74749 3.656765e-01 0.437 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 3.656765e-01 0.437 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.656765e-01 0.437 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.676668e-01 0.435 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 3.676668e-01 0.435 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.696911e-01 0.432 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 3.776253e-01 0.423 0 0
Neurexins and neuroligins R-HSA-6794361 3.779317e-01 0.423 0 0
Mitochondrial protein import R-HSA-1268020 3.842192e-01 0.415 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.858609e-01 0.414 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.869750e-01 0.412 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 3.883816e-01 0.411 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 3.885427e-01 0.411 0 0
PLC-gamma1 signalling R-HSA-167021 3.885427e-01 0.411 0 0
Axonal growth stimulation R-HSA-209563 3.885427e-01 0.411 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 3.885427e-01 0.411 0 0
MET activates PTPN11 R-HSA-8865999 3.885427e-01 0.411 0 0
Defective ABCA1 causes TGD R-HSA-5682113 3.885427e-01 0.411 0 0
Defective ABCC2 causes DJS R-HSA-5679001 3.885427e-01 0.411 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 3.885427e-01 0.411 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 3.885427e-01 0.411 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.902858e-01 0.409 0 0
Adaptive Immune System R-HSA-1280218 3.934092e-01 0.405 0 0
GAB1 signalosome R-HSA-180292 3.940261e-01 0.404 0 0
Polo-like kinase mediated events R-HSA-156711 3.940261e-01 0.404 0 0
Platelet sensitization by LDL R-HSA-432142 3.940261e-01 0.404 0 0
PKA activation in glucagon signalling R-HSA-164378 3.940261e-01 0.404 0 0
Transferrin endocytosis and recycling R-HSA-917977 3.968503e-01 0.401 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 3.989026e-01 0.399 0 0
Signaling by PTK6 R-HSA-8848021 3.989026e-01 0.399 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.003049e-01 0.398 0 0
Formation of the posterior neural plate R-HSA-9832991 4.003049e-01 0.398 0 0
Bicarbonate transporters R-HSA-425381 4.003049e-01 0.398 0 0
vRNP Assembly R-HSA-192905 4.003049e-01 0.398 0 0
Dissolution of Fibrin Clot R-HSA-75205 4.003049e-01 0.398 0 0
Ca2+ pathway R-HSA-4086398 4.029335e-01 0.395 0 0
EPHB-mediated forward signaling R-HSA-3928662 4.042544e-01 0.393 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 4.042544e-01 0.393 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 4.077837e-01 0.390 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.095832e-01 0.388 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.109708e-01 0.386 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.135903e-01 0.383 0 0
Mitochondrial biogenesis R-HSA-1592230 4.143776e-01 0.383 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 4.160164e-01 0.381 0 0
RNA Polymerase III Transcription R-HSA-74158 4.160164e-01 0.381 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.160164e-01 0.381 0 0
Signaling by ERBB4 R-HSA-1236394 4.166982e-01 0.380 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 4.200883e-01 0.377 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 4.214966e-01 0.375 0 0
Interleukin-1 signaling R-HSA-9020702 4.227786e-01 0.374 0 0
Selenocysteine synthesis R-HSA-2408557 4.227786e-01 0.374 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 4.295451e-01 0.367 0 0
Inflammasomes R-HSA-622312 4.295451e-01 0.367 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.321543e-01 0.364 0 0
Hemostasis R-HSA-109582 4.331109e-01 0.363 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.340166e-01 0.362 0 0
Activation of RAC1 R-HSA-428540 4.340166e-01 0.362 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.340166e-01 0.362 0 0
Signaling by AMER1 mutants R-HSA-4839748 4.340166e-01 0.362 0 0
Signaling by GSK3beta mutants R-HSA-5339716 4.340166e-01 0.362 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.340166e-01 0.362 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 4.340166e-01 0.362 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.357314e-01 0.361 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.386705e-01 0.358 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 4.457634e-01 0.351 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 4.457634e-01 0.351 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 4.457634e-01 0.351 0 0
HCN channels R-HSA-1296061 4.458448e-01 0.351 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.458448e-01 0.351 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.458448e-01 0.351 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.458448e-01 0.351 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.458448e-01 0.351 0 0
Signaling by MAP2K mutants R-HSA-9652169 4.458448e-01 0.351 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.458448e-01 0.351 0 0
Regulation of gap junction activity R-HSA-191650 4.458448e-01 0.351 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.458448e-01 0.351 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.458448e-01 0.351 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 4.458448e-01 0.351 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.458448e-01 0.351 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.458448e-01 0.351 0 0
Viral mRNA Translation R-HSA-192823 4.463302e-01 0.350 0 0
DARPP-32 events R-HSA-180024 4.510882e-01 0.346 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.510882e-01 0.346 0 0
Elastic fibre formation R-HSA-1566948 4.540059e-01 0.343 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.568203e-01 0.340 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.666795e-01 0.331 0 0
Repression of WNT target genes R-HSA-4641265 4.666795e-01 0.331 0 0
Leading Strand Synthesis R-HSA-69109 4.666795e-01 0.331 0 0
Polymerase switching R-HSA-69091 4.666795e-01 0.331 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 4.666795e-01 0.331 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 4.666795e-01 0.331 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 4.666795e-01 0.331 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 4.666795e-01 0.331 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 4.666795e-01 0.331 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.666795e-01 0.331 0 0
Regulation of IFNG signaling R-HSA-877312 4.666795e-01 0.331 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.666795e-01 0.331 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 4.709728e-01 0.327 0 0
GPER1 signaling R-HSA-9634597 4.726960e-01 0.325 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 4.804052e-01 0.318 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.814727e-01 0.317 0 0
Sensory processing of sound R-HSA-9659379 4.850508e-01 0.314 0 0
Peroxisomal protein import R-HSA-9033241 4.878802e-01 0.312 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.912874e-01 0.309 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 4.915672e-01 0.308 0 0
Attachment and Entry R-HSA-9694614 4.956486e-01 0.305 0 0
Mitochondrial calcium ion transport R-HSA-8949215 4.956486e-01 0.305 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 4.977800e-01 0.303 0 0
Activation of C3 and C5 R-HSA-174577 4.977800e-01 0.303 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.977800e-01 0.303 0 0
NrCAM interactions R-HSA-447038 4.977800e-01 0.303 0 0
Co-inhibition by BTLA R-HSA-9927353 4.977800e-01 0.303 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.977800e-01 0.303 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.981941e-01 0.303 0 0
Formation of axial mesoderm R-HSA-9796292 4.981941e-01 0.303 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.057026e-01 0.296 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 5.065640e-01 0.295 0 0
Signaling by FGFR R-HSA-190236 5.068342e-01 0.295 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.095785e-01 0.293 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.118909e-01 0.291 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.139168e-01 0.289 0 0
Signaling by WNT in cancer R-HSA-4791275 5.139168e-01 0.289 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 5.184000e-01 0.285 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 5.197332e-01 0.284 0 0
FGFR2 alternative splicing R-HSA-6803529 5.197332e-01 0.284 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.197332e-01 0.284 0 0
Signal regulatory protein family interactions R-HSA-391160 5.284889e-01 0.277 0 0
Zinc transporters R-HSA-435354 5.284889e-01 0.277 0 0
Heme signaling R-HSA-9707616 5.334108e-01 0.273 0 0
G-protein beta:gamma signalling R-HSA-397795 5.341197e-01 0.272 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.341197e-01 0.272 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.341197e-01 0.272 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 5.387293e-01 0.269 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.389233e-01 0.268 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.389233e-01 0.268 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.431785e-01 0.265 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.431785e-01 0.265 0 0
Termination of O-glycan biosynthesis R-HSA-977068 5.431785e-01 0.265 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 5.431785e-01 0.265 0 0
Growth hormone receptor signaling R-HSA-982772 5.431785e-01 0.265 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.448506e-01 0.264 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.448506e-01 0.264 0 0
Phosphorylation of Emi1 R-HSA-176417 5.448506e-01 0.264 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.448506e-01 0.264 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.448506e-01 0.264 0 0
Cam-PDE 1 activation R-HSA-111957 5.448506e-01 0.264 0 0
Ceramide signalling R-HSA-193681 5.448506e-01 0.264 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.448506e-01 0.264 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.448506e-01 0.264 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.448506e-01 0.264 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.448506e-01 0.264 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.448506e-01 0.264 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.453173e-01 0.263 0 0
Disorders of transmembrane transporters R-HSA-5619115 5.473713e-01 0.262 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.482330e-01 0.261 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.500375e-01 0.260 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 5.538944e-01 0.257 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.538944e-01 0.257 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 5.538944e-01 0.257 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 5.575156e-01 0.254 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.575156e-01 0.254 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 5.575156e-01 0.254 0 0
DCC mediated attractive signaling R-HSA-418885 5.575156e-01 0.254 0 0
Formation of the anterior neural plate R-HSA-9823739 5.575156e-01 0.254 0 0
Signaling by SCF-KIT R-HSA-1433557 5.627150e-01 0.250 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 5.659453e-01 0.247 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.659453e-01 0.247 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.659453e-01 0.247 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.659453e-01 0.247 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.732126e-01 0.242 0 0
NOD1/2 Signaling Pathway R-HSA-168638 5.732126e-01 0.242 0 0
DAP12 interactions R-HSA-2172127 5.797695e-01 0.237 0 0
Netrin-1 signaling R-HSA-373752 5.797695e-01 0.237 0 0
Signaling by NOTCH1 R-HSA-1980143 5.835280e-01 0.234 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.852459e-01 0.233 0 0
Virus Assembly and Release R-HSA-168268 5.852459e-01 0.233 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 5.875121e-01 0.231 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.875121e-01 0.231 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.875121e-01 0.231 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 5.875121e-01 0.231 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 5.875121e-01 0.231 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 5.875121e-01 0.231 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.875121e-01 0.231 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.875121e-01 0.231 0 0
HDL clearance R-HSA-8964011 5.875121e-01 0.231 0 0
Nef and signal transduction R-HSA-164944 5.875121e-01 0.231 0 0
HDMs demethylate histones R-HSA-3214842 5.880021e-01 0.231 0 0
Formation of the nephric duct R-HSA-9830364 5.880021e-01 0.231 0 0
Signalling to ERKs R-HSA-187687 5.920504e-01 0.228 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 5.964622e-01 0.224 0 0
Translation of Structural Proteins R-HSA-9694635 5.966976e-01 0.224 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 6.064304e-01 0.217 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.093250e-01 0.215 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 6.093250e-01 0.215 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 6.093250e-01 0.215 0 0
Triglyceride catabolism R-HSA-163560 6.103875e-01 0.214 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.116678e-01 0.213 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.116678e-01 0.213 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.116678e-01 0.213 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 6.127769e-01 0.213 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 6.127769e-01 0.213 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.261771e-01 0.203 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.261771e-01 0.203 0 0
SOS-mediated signalling R-HSA-112412 6.261771e-01 0.203 0 0
Disinhibition of SNARE formation R-HSA-114516 6.261771e-01 0.203 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.261771e-01 0.203 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.261771e-01 0.203 0 0
PTK6 Expression R-HSA-8849473 6.261771e-01 0.203 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.261771e-01 0.203 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.261771e-01 0.203 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.261771e-01 0.203 0 0
VLDL clearance R-HSA-8964046 6.261771e-01 0.203 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 6.261771e-01 0.203 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.298969e-01 0.201 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.298969e-01 0.201 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 6.298969e-01 0.201 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.298969e-01 0.201 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 6.298969e-01 0.201 0 0
Insulin processing R-HSA-264876 6.298969e-01 0.201 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 6.302717e-01 0.200 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 6.367828e-01 0.196 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 6.367828e-01 0.196 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.367828e-01 0.196 0 0
Specification of primordial germ cells R-HSA-9827857 6.367828e-01 0.196 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.367828e-01 0.196 0 0
Co-stimulation by CD28 R-HSA-389356 6.442195e-01 0.191 0 0
MET promotes cell motility R-HSA-8875878 6.454976e-01 0.190 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 6.454976e-01 0.190 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.460827e-01 0.190 0 0
Post-translational protein modification R-HSA-597592 6.486562e-01 0.188 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.489491e-01 0.188 0 0
HIV elongation arrest and recovery R-HSA-167287 6.497064e-01 0.187 0 0
Pausing and recovery of HIV elongation R-HSA-167290 6.497064e-01 0.187 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 6.497064e-01 0.187 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 6.497064e-01 0.187 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.574409e-01 0.182 0 0
tRNA Aminoacylation R-HSA-379724 6.583131e-01 0.182 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 6.583131e-01 0.182 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 6.583131e-01 0.182 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 6.583131e-01 0.182 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 6.583131e-01 0.182 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 6.583131e-01 0.182 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.606039e-01 0.180 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 6.606039e-01 0.180 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 6.606039e-01 0.180 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.606039e-01 0.180 0 0
Presynaptic function of Kainate receptors R-HSA-500657 6.606039e-01 0.180 0 0
Nephron development R-HSA-9831926 6.606039e-01 0.180 0 0
Apoptotic factor-mediated response R-HSA-111471 6.606039e-01 0.180 0 0
phospho-PLA2 pathway R-HSA-111995 6.612199e-01 0.180 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.612199e-01 0.180 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.612199e-01 0.180 0 0
MET receptor recycling R-HSA-8875656 6.612199e-01 0.180 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.612199e-01 0.180 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 6.612199e-01 0.180 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.612199e-01 0.180 0 0
Adrenoceptors R-HSA-390696 6.612199e-01 0.180 0 0
Sodium/Proton exchangers R-HSA-425986 6.612199e-01 0.180 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.612199e-01 0.180 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.622478e-01 0.179 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.634900e-01 0.178 0 0
Signaling by Erythropoietin R-HSA-9006335 6.687478e-01 0.175 0 0
mRNA Capping R-HSA-72086 6.687478e-01 0.175 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.687478e-01 0.175 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.710324e-01 0.173 0 0
Signaling by Insulin receptor R-HSA-74752 6.716525e-01 0.173 0 0
Aquaporin-mediated transport R-HSA-445717 6.718268e-01 0.173 0 0
Gastrulation R-HSA-9758941 6.722199e-01 0.172 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.740126e-01 0.171 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.784515e-01 0.168 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.831528e-01 0.165 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.831528e-01 0.165 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.831528e-01 0.165 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.831528e-01 0.165 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.831528e-01 0.165 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.831528e-01 0.165 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.831528e-01 0.165 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 6.831528e-01 0.165 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.831528e-01 0.165 0 0
Other interleukin signaling R-HSA-449836 6.831528e-01 0.165 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.870199e-01 0.163 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.870199e-01 0.163 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 6.870199e-01 0.163 0 0
Lipophagy R-HSA-9613354 6.929796e-01 0.159 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.929796e-01 0.159 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.929796e-01 0.159 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.929796e-01 0.159 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 6.929796e-01 0.159 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.929796e-01 0.159 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.929796e-01 0.159 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.929796e-01 0.159 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 7.021033e-01 0.154 0 0
RSV-host interactions R-HSA-9833110 7.032080e-01 0.153 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.044587e-01 0.152 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.044587e-01 0.152 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 7.044587e-01 0.152 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.044587e-01 0.152 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.044587e-01 0.152 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.044587e-01 0.152 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.044587e-01 0.152 0 0
Co-inhibition by CTLA4 R-HSA-389513 7.044587e-01 0.152 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.048965e-01 0.152 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 7.092057e-01 0.149 0 0
HIV Transcription Initiation R-HSA-167161 7.092057e-01 0.149 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 7.092057e-01 0.149 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.125154e-01 0.147 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 7.156659e-01 0.145 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.212715e-01 0.142 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.212715e-01 0.142 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.212715e-01 0.142 0 0
G0 and Early G1 R-HSA-1538133 7.212726e-01 0.142 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.212726e-01 0.142 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.217637e-01 0.142 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 7.217637e-01 0.142 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.217637e-01 0.142 0 0
PI3K/AKT activation R-HSA-198203 7.217637e-01 0.142 0 0
Binding and entry of HIV virion R-HSA-173107 7.217637e-01 0.142 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 7.217637e-01 0.142 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.217637e-01 0.142 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 7.217637e-01 0.142 0 0
Metal sequestration by antimicrobial proteins R-HSA-6799990 7.217637e-01 0.142 0 0
Interleukin-27 signaling R-HSA-9020956 7.217637e-01 0.142 0 0
Maturation of spike protein R-HSA-9683686 7.217637e-01 0.142 0 0
Signaling by Leptin R-HSA-2586552 7.217637e-01 0.142 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.245565e-01 0.140 0 0
Lagging Strand Synthesis R-HSA-69186 7.245565e-01 0.140 0 0
G-protein activation R-HSA-202040 7.245565e-01 0.140 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 7.245565e-01 0.140 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.245565e-01 0.140 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 7.245565e-01 0.140 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 7.245565e-01 0.140 0 0
Pyruvate metabolism R-HSA-70268 7.261718e-01 0.139 0 0
SLC transporter disorders R-HSA-5619102 7.300395e-01 0.137 0 0
Integrin signaling R-HSA-354192 7.372701e-01 0.132 0 0
Nuclear RNA decay R-HSA-9930044 7.372701e-01 0.132 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.377572e-01 0.132 0 0
TBC/RABGAPs R-HSA-8854214 7.377572e-01 0.132 0 0
Neddylation R-HSA-8951664 7.404298e-01 0.131 0 0
Stimuli-sensing channels R-HSA-2672351 7.410273e-01 0.130 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.432739e-01 0.129 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.432739e-01 0.129 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.432739e-01 0.129 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.434853e-01 0.129 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 7.434853e-01 0.129 0 0
Serine metabolism R-HSA-977347 7.434853e-01 0.129 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 7.434853e-01 0.129 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.478506e-01 0.126 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.478506e-01 0.126 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.478506e-01 0.126 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.478506e-01 0.126 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.478506e-01 0.126 0 0
vRNA Synthesis R-HSA-192814 7.478506e-01 0.126 0 0
Signaling by APC mutants R-HSA-4839744 7.478506e-01 0.126 0 0
Synthesis of PI R-HSA-1483226 7.478506e-01 0.126 0 0
Propionyl-CoA catabolism R-HSA-71032 7.478506e-01 0.126 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.478506e-01 0.126 0 0
Suppression of apoptosis R-HSA-9635465 7.478506e-01 0.126 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.478506e-01 0.126 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.506673e-01 0.125 0 0
Extracellular matrix organization R-HSA-1474244 7.513083e-01 0.124 0 0
Toll-like Receptor Cascades R-HSA-168898 7.519937e-01 0.124 0 0
Miscellaneous transport and binding events R-HSA-5223345 7.525312e-01 0.123 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.525312e-01 0.123 0 0
Signaling by NTRKs R-HSA-166520 7.527414e-01 0.123 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.531019e-01 0.123 0 0
Downstream TCR signaling R-HSA-202424 7.560973e-01 0.121 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.564351e-01 0.121 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.564351e-01 0.121 0 0
Transcription of the HIV genome R-HSA-167172 7.565598e-01 0.121 0 0
tRNA processing R-HSA-72306 7.589778e-01 0.120 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.612876e-01 0.118 0 0
Notch-HLH transcription pathway R-HSA-350054 7.612876e-01 0.118 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.612876e-01 0.118 0 0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy R-HSA-9857377 7.612876e-01 0.118 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.641358e-01 0.117 0 0
Somitogenesis R-HSA-9824272 7.641358e-01 0.117 0 0
Infectious disease R-HSA-5663205 7.644623e-01 0.117 0 0
Dectin-2 family R-HSA-5621480 7.647771e-01 0.116 0 0
Transmission across Chemical Synapses R-HSA-112315 7.658542e-01 0.116 0 0
Signal amplification R-HSA-392518 7.670710e-01 0.115 0 0
eNOS activation R-HSA-203615 7.670710e-01 0.115 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.670710e-01 0.115 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 7.704581e-01 0.113 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 7.714932e-01 0.113 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.714932e-01 0.113 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 7.714932e-01 0.113 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.714932e-01 0.113 0 0
Signaling by AXIN mutants R-HSA-4839735 7.714932e-01 0.113 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.714932e-01 0.113 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 7.714932e-01 0.113 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 7.714932e-01 0.113 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.714932e-01 0.113 0 0
Sodium/Calcium exchangers R-HSA-425561 7.714932e-01 0.113 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 7.780083e-01 0.109 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.780083e-01 0.109 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.780083e-01 0.109 0 0
Adipogenesis R-HSA-9843745 7.780428e-01 0.109 0 0
Cardiac conduction R-HSA-5576891 7.780428e-01 0.109 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.804723e-01 0.108 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.804723e-01 0.108 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.809067e-01 0.107 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.809067e-01 0.107 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.809067e-01 0.107 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 7.836331e-01 0.106 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 7.857824e-01 0.105 0 0
Triglyceride metabolism R-HSA-8979227 7.868634e-01 0.104 0 0
Selenoamino acid metabolism R-HSA-2408522 7.869695e-01 0.104 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.922850e-01 0.101 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.929201e-01 0.101 0 0
Maple Syrup Urine Disease R-HSA-9865114 7.929201e-01 0.101 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 7.929201e-01 0.101 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 7.929201e-01 0.101 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 7.929201e-01 0.101 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.929201e-01 0.101 0 0
Signaling by LTK R-HSA-9842663 7.929201e-01 0.101 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.929201e-01 0.101 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.929201e-01 0.101 0 0
Interleukin-35 Signalling R-HSA-8984722 7.929201e-01 0.101 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 7.929201e-01 0.101 0 0
OAS antiviral response R-HSA-8983711 7.929201e-01 0.101 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.936936e-01 0.100 0 0
Mitochondrial RNA degradation R-HSA-9836573 7.936936e-01 0.100 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 7.940570e-01 0.100 0 0
G1/S-Specific Transcription R-HSA-69205 7.940570e-01 0.100 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.972858e-01 0.098 0 0
NGF-stimulated transcription R-HSA-9031628 7.997596e-01 0.097 0 0
Metal ion SLC transporters R-HSA-425410 7.997596e-01 0.097 0 0
Mitochondrial protein degradation R-HSA-9837999 8.006768e-01 0.097 0 0
Generic Transcription Pathway R-HSA-212436 8.059582e-01 0.094 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.065419e-01 0.093 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 8.073030e-01 0.093 0 0
MAP kinase activation R-HSA-450294 8.073030e-01 0.093 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.083905e-01 0.092 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 8.083905e-01 0.092 0 0
G protein gated Potassium channels R-HSA-1296059 8.083905e-01 0.092 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 8.083905e-01 0.092 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.083905e-01 0.092 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.083905e-01 0.092 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.083905e-01 0.092 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 8.083905e-01 0.092 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.083905e-01 0.092 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 8.123390e-01 0.090 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.123390e-01 0.090 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.123390e-01 0.090 0 0
Processing of SMDT1 R-HSA-8949664 8.123390e-01 0.090 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.123390e-01 0.090 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 8.123390e-01 0.090 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 8.123390e-01 0.090 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.123390e-01 0.090 0 0
Maturation of nucleoprotein R-HSA-9683610 8.123390e-01 0.090 0 0
Interleukin-6 signaling R-HSA-1059683 8.123390e-01 0.090 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 8.123390e-01 0.090 0 0
Signaling by PDGF R-HSA-186797 8.169226e-01 0.088 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 8.183824e-01 0.087 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.183824e-01 0.087 0 0
Integration of energy metabolism R-HSA-163685 8.198115e-01 0.086 0 0
PI3K Cascade R-HSA-109704 8.209983e-01 0.086 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.221466e-01 0.085 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.221466e-01 0.085 0 0
Urea cycle R-HSA-70635 8.221466e-01 0.085 0 0
MET activates PTK2 signaling R-HSA-8874081 8.221466e-01 0.085 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 8.236509e-01 0.084 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.242081e-01 0.084 0 0
Innate Immune System R-HSA-168249 8.243096e-01 0.084 0 0
Rab regulation of trafficking R-HSA-9007101 8.276129e-01 0.082 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.296006e-01 0.081 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.296006e-01 0.081 0 0
Removal of the Flap Intermediate R-HSA-69166 8.299380e-01 0.081 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.299380e-01 0.081 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.299380e-01 0.081 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.299380e-01 0.081 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.299380e-01 0.081 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.299380e-01 0.081 0 0
Hydrolysis of LPC R-HSA-1483115 8.299380e-01 0.081 0 0
Malate-aspartate shuttle R-HSA-9856872 8.299380e-01 0.081 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.299380e-01 0.081 0 0
Acyl chain remodeling of CL R-HSA-1482798 8.299380e-01 0.081 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 8.299380e-01 0.081 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.326997e-01 0.080 0 0
Insulin receptor signalling cascade R-HSA-74751 8.350018e-01 0.078 0 0
IGF1R signaling cascade R-HSA-2428924 8.350018e-01 0.078 0 0
Regulation of insulin secretion R-HSA-422356 8.388304e-01 0.076 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.394661e-01 0.076 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.402186e-01 0.076 0 0
HIV Transcription Elongation R-HSA-167169 8.402186e-01 0.076 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.402186e-01 0.076 0 0
Diseases of Immune System R-HSA-5260271 8.402186e-01 0.076 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.402186e-01 0.076 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 8.403641e-01 0.076 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 8.406756e-01 0.075 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.422285e-01 0.075 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 8.434790e-01 0.074 0 0
Erythropoietin activates RAS R-HSA-9027284 8.458874e-01 0.073 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.458874e-01 0.073 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.458874e-01 0.073 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.458874e-01 0.073 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.458874e-01 0.073 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.458874e-01 0.073 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 8.458874e-01 0.073 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.458874e-01 0.073 0 0
Protein lipoylation R-HSA-9857492 8.458874e-01 0.073 0 0
Other semaphorin interactions R-HSA-416700 8.458874e-01 0.073 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.458874e-01 0.073 0 0
DNA Damage Reversal R-HSA-73942 8.458874e-01 0.073 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.470240e-01 0.072 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.470240e-01 0.072 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.470240e-01 0.072 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.493370e-01 0.071 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.498956e-01 0.071 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.502593e-01 0.070 0 0
Maturation of spike protein R-HSA-9694548 8.502593e-01 0.070 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 8.582378e-01 0.066 0 0
Thyroxine biosynthesis R-HSA-209968 8.582378e-01 0.066 0 0
Platelet calcium homeostasis R-HSA-418360 8.582378e-01 0.066 0 0
Glucagon-type ligand receptors R-HSA-420092 8.582378e-01 0.066 0 0
Intra-Golgi traffic R-HSA-6811438 8.597456e-01 0.066 0 0
Phosphorylation of the APC/C R-HSA-176412 8.603419e-01 0.065 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.603419e-01 0.065 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.603419e-01 0.065 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 8.603419e-01 0.065 0 0
Killing mechanisms R-HSA-9664420 8.603419e-01 0.065 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 8.603419e-01 0.065 0 0
Activation of SMO R-HSA-5635838 8.603419e-01 0.065 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 8.603419e-01 0.065 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.603419e-01 0.065 0 0
Attachment and Entry R-HSA-9678110 8.603419e-01 0.065 0 0
Atorvastatin ADME R-HSA-9754706 8.603419e-01 0.065 0 0
Metabolism of proteins R-HSA-392499 8.625573e-01 0.064 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.644074e-01 0.063 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 8.686947e-01 0.061 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.686947e-01 0.061 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.686947e-01 0.061 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 8.686947e-01 0.061 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.686947e-01 0.061 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.734414e-01 0.059 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.734414e-01 0.059 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.734414e-01 0.059 0 0
Fibronectin matrix formation R-HSA-1566977 8.734414e-01 0.059 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.734414e-01 0.059 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.734414e-01 0.059 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.734414e-01 0.059 0 0
Passive transport by Aquaporins R-HSA-432047 8.734414e-01 0.059 0 0
Coenzyme A biosynthesis R-HSA-196783 8.734414e-01 0.059 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 8.734414e-01 0.059 0 0
Downstream signal transduction R-HSA-186763 8.784381e-01 0.056 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.784381e-01 0.056 0 0
Interleukin-17 signaling R-HSA-448424 8.806248e-01 0.055 0 0
IRS-mediated signalling R-HSA-112399 8.811326e-01 0.055 0 0
Proteasome assembly R-HSA-9907900 8.851066e-01 0.053 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 8.853130e-01 0.053 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 8.853130e-01 0.053 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.853130e-01 0.053 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 8.853130e-01 0.053 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 8.853130e-01 0.053 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.853130e-01 0.053 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 8.853130e-01 0.053 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.853130e-01 0.053 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 8.853130e-01 0.053 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 8.853130e-01 0.053 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 8.853130e-01 0.053 0 0
ECM proteoglycans R-HSA-3000178 8.870765e-01 0.052 0 0
Inwardly rectifying K+ channels R-HSA-1296065 8.875097e-01 0.052 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.875097e-01 0.052 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 8.926029e-01 0.049 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.947227e-01 0.048 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 8.959498e-01 0.048 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 8.960716e-01 0.048 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 8.960716e-01 0.048 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.960716e-01 0.048 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.960716e-01 0.048 0 0
Mismatch Repair R-HSA-5358508 8.960716e-01 0.048 0 0
Neuronal System R-HSA-112316 8.988573e-01 0.046 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.991521e-01 0.046 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.996573e-01 0.046 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.037971e-01 0.044 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.046624e-01 0.044 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.058215e-01 0.043 0 0
Specification of the neural plate border R-HSA-9834899 9.058215e-01 0.043 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.058215e-01 0.043 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.058215e-01 0.043 0 0
Maturation of nucleoprotein R-HSA-9694631 9.058215e-01 0.043 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 9.058215e-01 0.043 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.062911e-01 0.043 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.069281e-01 0.042 0 0
Leishmania infection R-HSA-9658195 9.107207e-01 0.041 0 0
Parasitic Infection Pathways R-HSA-9824443 9.107207e-01 0.041 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.110885e-01 0.040 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.110885e-01 0.040 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.110885e-01 0.040 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.125468e-01 0.040 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.125468e-01 0.040 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.135129e-01 0.039 0 0
FOXO-mediated transcription R-HSA-9614085 9.144294e-01 0.039 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.146573e-01 0.039 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 9.146573e-01 0.039 0 0
Signaling by NODAL R-HSA-1181150 9.146573e-01 0.039 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.146573e-01 0.039 0 0
Creatine metabolism R-HSA-71288 9.146573e-01 0.039 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.146573e-01 0.039 0 0
Pregnenolone biosynthesis R-HSA-196108 9.146573e-01 0.039 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.178591e-01 0.037 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.178591e-01 0.037 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 9.226645e-01 0.035 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.226645e-01 0.035 0 0
RUNX2 regulates bone development R-HSA-8941326 9.241424e-01 0.034 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.241424e-01 0.034 0 0
Formation of the cornified envelope R-HSA-6809371 9.246313e-01 0.034 0 0
The phototransduction cascade R-HSA-2514856 9.290283e-01 0.032 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.299210e-01 0.032 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.299210e-01 0.032 0 0
Glutathione synthesis and recycling R-HSA-174403 9.299210e-01 0.032 0 0
Ribavirin ADME R-HSA-9755088 9.299210e-01 0.032 0 0
NCAM1 interactions R-HSA-419037 9.299704e-01 0.032 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.353730e-01 0.029 0 0
Kidney development R-HSA-9830369 9.363388e-01 0.029 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.364969e-01 0.028 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.364969e-01 0.028 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 9.364969e-01 0.028 0 0
Signaling by KIT in disease R-HSA-9669938 9.364969e-01 0.028 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.364969e-01 0.028 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.364969e-01 0.028 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.364969e-01 0.028 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.373162e-01 0.028 0 0
Interferon alpha/beta signaling R-HSA-909733 9.373162e-01 0.028 0 0
Pentose phosphate pathway R-HSA-71336 9.403787e-01 0.027 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.403787e-01 0.027 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.424561e-01 0.026 0 0
Formation of the ureteric bud R-HSA-9830674 9.424561e-01 0.026 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.424561e-01 0.026 0 0
Carnitine shuttle R-HSA-200425 9.424561e-01 0.026 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.424561e-01 0.026 0 0
Platelet homeostasis R-HSA-418346 9.437682e-01 0.025 0 0
Leishmania phagocytosis R-HSA-9664417 9.441516e-01 0.025 0 0
Parasite infection R-HSA-9664407 9.441516e-01 0.025 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.441516e-01 0.025 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.450145e-01 0.025 0 0
G alpha (z) signalling events R-HSA-418597 9.465903e-01 0.024 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 9.478565e-01 0.023 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.478565e-01 0.023 0 0
Interleukin-6 family signaling R-HSA-6783589 9.478565e-01 0.023 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.509604e-01 0.022 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 9.527503e-01 0.021 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.527503e-01 0.021 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.527503e-01 0.021 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 9.532761e-01 0.021 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.532761e-01 0.021 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.532761e-01 0.021 0 0
Synthesis of PA R-HSA-1483166 9.537687e-01 0.021 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.540986e-01 0.020 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.560700e-01 0.020 0 0
Activation of GABAB receptors R-HSA-991365 9.569481e-01 0.019 0 0
GABA B receptor activation R-HSA-977444 9.569481e-01 0.019 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.569481e-01 0.019 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.570509e-01 0.019 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.571851e-01 0.019 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.571851e-01 0.019 0 0
TRP channels R-HSA-3295583 9.571851e-01 0.019 0 0
Sphingolipid catabolism R-HSA-9845614 9.571851e-01 0.019 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.571851e-01 0.019 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.595180e-01 0.018 0 0
Extension of Telomeres R-HSA-180786 9.600368e-01 0.018 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.600368e-01 0.018 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.603496e-01 0.018 0 0
Interferon gamma signaling R-HSA-877300 9.603502e-01 0.018 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 9.612038e-01 0.017 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.612038e-01 0.017 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.612038e-01 0.017 0 0
Triglyceride biosynthesis R-HSA-75109 9.612038e-01 0.017 0 0
Synthesis of PE R-HSA-1483213 9.612038e-01 0.017 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.612038e-01 0.017 0 0
Metabolism of polyamines R-HSA-351202 9.628629e-01 0.016 0 0
Amine ligand-binding receptors R-HSA-375280 9.634797e-01 0.016 0 0
Telomere Extension By Telomerase R-HSA-171319 9.648456e-01 0.016 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.648456e-01 0.016 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.681457e-01 0.014 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.681457e-01 0.014 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.681457e-01 0.014 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.681457e-01 0.014 0 0
Diseases of DNA repair R-HSA-9675135 9.690531e-01 0.014 0 0
Interleukin-10 signaling R-HSA-6783783 9.693486e-01 0.014 0 0
Complex I biogenesis R-HSA-6799198 9.702533e-01 0.013 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.711362e-01 0.013 0 0
Synthesis of PC R-HSA-1483191 9.715230e-01 0.013 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.723907e-01 0.012 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.731644e-01 0.012 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.751429e-01 0.011 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.759044e-01 0.011 0 0
HS-GAG degradation R-HSA-2024096 9.763018e-01 0.010 0 0
Azathioprine ADME R-HSA-9748787 9.778431e-01 0.010 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.779626e-01 0.010 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.782925e-01 0.010 0 0
Cardiogenesis R-HSA-9733709 9.785270e-01 0.009 0 0
Recycling of bile acids and salts R-HSA-159418 9.785270e-01 0.009 0 0
O-linked glycosylation of mucins R-HSA-913709 9.795689e-01 0.009 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.800858e-01 0.009 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.805433e-01 0.009 0 0
Heme degradation R-HSA-189483 9.805433e-01 0.009 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.808411e-01 0.008 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.823705e-01 0.008 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.823705e-01 0.008 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.823705e-01 0.008 0 0
COPII-mediated vesicle transport R-HSA-204005 9.824527e-01 0.008 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.849448e-01 0.007 0 0
Paracetamol ADME R-HSA-9753281 9.854797e-01 0.006 0 0
HS-GAG biosynthesis R-HSA-2022928 9.855264e-01 0.006 0 0
Glycosphingolipid transport R-HSA-9845576 9.855264e-01 0.006 0 0
PI Metabolism R-HSA-1483255 9.862649e-01 0.006 0 0
Disease R-HSA-1643685 9.866393e-01 0.006 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.866645e-01 0.006 0 0
Voltage gated Potassium channels R-HSA-1296072 9.868858e-01 0.006 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.868858e-01 0.006 0 0
Collagen chain trimerization R-HSA-8948216 9.868858e-01 0.006 0 0
Metabolism of folate and pterines R-HSA-196757 9.868858e-01 0.006 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.880569e-01 0.005 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.881176e-01 0.005 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.896299e-01 0.005 0 0
Interleukin-2 family signaling R-HSA-451927 9.902452e-01 0.004 0 0
GABA receptor activation R-HSA-977443 9.905301e-01 0.004 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.911617e-01 0.004 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.912645e-01 0.004 0 0
Collagen degradation R-HSA-1442490 9.913106e-01 0.004 0 0
Collagen formation R-HSA-1474290 9.914216e-01 0.004 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.919920e-01 0.003 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.925636e-01 0.003 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.931154e-01 0.003 0 0
Potassium Channels R-HSA-1296071 9.931154e-01 0.003 0 0
Surfactant metabolism R-HSA-5683826 9.940440e-01 0.003 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.941178e-01 0.003 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.943614e-01 0.002 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.944853e-01 0.002 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.946037e-01 0.002 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.955703e-01 0.002 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.960114e-01 0.002 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.960114e-01 0.002 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.960212e-01 0.002 0 0
Peptide hormone metabolism R-HSA-2980736 9.960454e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.963270e-01 0.002 0 0
Metabolism of cofactors R-HSA-8978934 9.963546e-01 0.002 0 0
Neurotransmitter release cycle R-HSA-112310 9.966361e-01 0.001 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 9.967057e-01 0.001 0 0
Aspirin ADME R-HSA-9749641 9.969411e-01 0.001 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.970154e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.970154e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.975502e-01 0.001 0 0
Cholesterol biosynthesis R-HSA-191273 9.980313e-01 0.001 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.982451e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.982878e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.984256e-01 0.001 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.986455e-01 0.001 0 0
Regulation of beta-cell development R-HSA-186712 9.986455e-01 0.001 0 0
Glutathione conjugation R-HSA-156590 9.987729e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.987729e-01 0.001 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.988442e-01 0.001 0 0
Respiratory electron transport R-HSA-611105 9.988791e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.993421e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.993647e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.993820e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.993855e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.993855e-01 0.000 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.994433e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.994855e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.995205e-01 0.000 0 0
Keratinization R-HSA-6805567 9.995366e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.995862e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.995862e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.996035e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.996251e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.996399e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.997200e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.997831e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.998176e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998407e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.998461e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999272e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999432e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999468e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999540e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999615e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999662e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999673e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999741e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999787e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999815e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999840e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999935e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999947e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999964e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999964e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999981e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999983e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999989e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999991e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999993e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999998e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999999e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999999e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999999e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways