CDC7

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
Log-Odds: S Sites / S Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O00311 S216 EPSD|PSP CDC7 CDC7L1 DFGLAQGTHDTKIELLKFVQsEAQQERCSQNKSHIITGNKI
O00311 S239 EPSD|PSP CDC7 CDC7L1 QQERCSQNKSHIITGNKIPLsGPVPKELDQQSTTKASVKRP
O00311 S277 EPSD|PSP CDC7 CDC7L1 KRPYTNAQIQIKQGKDGKEGsVGLsVQRsVFGERNFNIHss
O00311 S285 EPSD|PSP CDC7 CDC7L1 IQIKQGKDGKEGsVGLsVQRsVFGERNFNIHssISHEsPAV
O00311 S296 EPSD|PSP CDC7 CDC7L1 GsVGLsVQRsVFGERNFNIHssISHEsPAVKLMKQSKTVDV
O00311 S297 EPSD|PSP CDC7 CDC7L1 sVGLsVQRsVFGERNFNIHssISHEsPAVKLMKQSKTVDVL
O00311 S318 EPSD|PSP CDC7 CDC7L1 ISHEsPAVKLMKQSKTVDVLsRKLATKKKAISTKVMNSAVM
O75475 S206 SIGNOR|EPSD|PSP PSIP1 DFS70 LEDGF PSIP2 TEVKIPKPRGRPKMVKQPCPsEsDIItEEDKSKKKGQEEKQ
P06748 S137 EPSD|PSP NPM1 NPM VAVEEDAEsEDEEEEDVKLLsIsGKRsAPGGGsKVPQKKVK
P06748 T199 EPSD|PSP NPM1 NPM DDFDDEEAEEKAPVKKsIRDtPAKNAQKSNQNGKDsKPsst
P11388 S1213 EPSD|PSP TOP2A TOP2 LPGKGGKAKGKKTQMAEVLPsPRGQRVIPRITIEMKAEAEK
P11388 S1525 EPSD|PSP TOP2A TOP2 AVAPRAKSVRAKKPIKYLEEsDEDDLF______________
P19338 T121 EPSD|PSP NCL AKAVTtPGKKGAtPGKALVAtPGKKGAAIPAKGAKNGKNAK
P19338 T76 EPSD|PSP NCL AAATsAKKVVVsPtKKVAVAtPAKKAAVtPGKKAAAtPAKK
P49736 S108 GPS6|SIGNOR|EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 DAYEAEGLALDDEDVEELtAsQREAAERAMRQRDREAGRGL
P49736 S13 SIGNOR MCM2 BM28 CCNL1 CDCL1 KIAA0030 ________MAEssEsFtMAssPAQRRRGNDPLtssPGRssR
P49736 S139 SIGNOR|EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 QRDREAGRGLGRMRRGLLyDsDEEDEERPARKRRQVERAtE
P49736 S220 EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 KNFLRTHVDsHGHNVFKERIsDMCKENREsLVVNyEDLAAR
P49736 S27 SIGNOR|EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 sFtMAssPAQRRRGNDPLtssPGRssRRtDALtssPGRDLP
P49736 S31 EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 AssPAQRRRGNDPLtssPGRssRRtDALtssPGRDLPPFED
P49736 S4 EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 _________________MAEssEsFtMAssPAQRRRGNDPL
P49736 S40 GPS6|SIGNOR|EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 GNDPLtssPGRssRRtDALtssPGRDLPPFEDEsEGLLGtE
P49736 S41 SIGNOR|EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 NDPLtssPGRssRRtDALtssPGRDLPPFEDEsEGLLGtEG
P49736 S5 SIGNOR|EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 ________________MAEssEsFtMAssPAQRRRGNDPLt
P49736 S53 GPS6|SIGNOR|EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 RRtDALtssPGRDLPPFEDEsEGLLGtEGPLEEEEDGEELI
P49736 S7 EPSD|PSP MCM2 BM28 CCNL1 CDCL1 KIAA0030 ______________MAEssEsFtMAssPAQRRRGNDPLtss
P55081 S116 EPSD|PSP MFAP1 DVEERLARHRKIVEPEVVGEsDsEVEGDAWRMEREDssEEE
Q8TEA8 S179 SIGNOR|PSP DTD1 C20orf88 DUEB HARS2 QLSKLEKQQQRKEKTRAKGPsEssKERNtPRKEDRsAssGA
Q8TEA8 S181 SIGNOR|PSP DTD1 C20orf88 DUEB HARS2 SKLEKQQQRKEKTRAKGPsEssKERNtPRKEDRsAssGAEG
Q8TEA8 S182 SIGNOR|PSP DTD1 C20orf88 DUEB HARS2 KLEKQQQRKEKTRAKGPsEssKERNtPRKEDRsAssGAEGD
Q8TEA8 S194 SIGNOR|PSP DTD1 C20orf88 DUEB HARS2 RAKGPsEssKERNtPRKEDRsAssGAEGDVssEREP_____
Q8TEA8 S196 SIGNOR|PSP DTD1 C20orf88 DUEB HARS2 KGPsEssKERNtPRKEDRsAssGAEGDVssEREP_______
Q8TEA8 S197 SIGNOR|PSP DTD1 C20orf88 DUEB HARS2 GPsEssKERNtPRKEDRsAssGAEGDVssEREP________
Q8TEA8 S204 SIGNOR|PSP DTD1 C20orf88 DUEB HARS2 ERNtPRKEDRsAssGAEGDVssEREP_______________
Q8TEA8 S205 SIGNOR|PSP DTD1 C20orf88 DUEB HARS2 RNtPRKEDRsAssGAEGDVssEREP________________
Q8TEA8 T187 SIGNOR|PSP DTD1 C20orf88 DUEB HARS2 QQRKEKTRAKGPsEssKERNtPRKEDRsAssGAEGDVssER
Q96GD4 T236 PSP AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5 IADFGWSVHAPsLRRKtMCGtLDYLPPEMIEGRMHNEKVDL
Q9HAW4 S110 EPSD|PSP CLSPN ENLYAGKNTKIKRIYKTVADsDESYMEKSLyQENLEAQVKP
Q9HAW4 S1129 EPSD|PSP CLSPN DDKRQLRLYQERYLADGDLHsDGPGRMRKFRWKNIDDAsQM
Q9HAW4 S1147 EPSD|PSP CLSPN LHsDGPGRMRKFRWKNIDDAsQMDLFHRDsDDDQtEEQLDE
Q9HAW4 S260 EPSD|PSP CLSPN VKNKVKKHKKKEPSLESGVHsFEEGsELSKGTTRKERKAAR
Q9HAW4 S265 EPSD|PSP CLSPN KKHKKKEPSLESGVHsFEEGsELSKGTTRKERKAARLSKEA
Q9HAW4 S67 EPSD|PSP CLSPN DEEIFVSKKLKNRKVLQDsDsEtEDTNAsPEKttyDsAEEE
Q9HAW4 S704 EPSD|PSP CLSPN SEEIETKDEKEMDKENNDGssEIGKAVGFLSVPKSLssDst
Q9HAW4 S721 EPSD|PSP CLSPN DGssEIGKAVGFLSVPKSLssDstLLLFKDSSSKMGYFPTE
Q9HAW4 S744 EPSD|PSP CLSPN tLLLFKDSSSKMGYFPTEEKsETDENSGKQPSKLDEDDsCs
Q9NS91 S434 SIGNOR|EPSD|PSP RAD18 RNF73 EPDREEDSSSCIDIQEVLSSsESDSCNSSSSDIIRDLLEEE
Q9UBU7 S312 EPSD|PSP DBF4 ASK DBF4A ZDBF1 KKGYCECCLQKYEDLEtHLLsEQHRNFAQSNQYQVVDDIVS
Q9UBU7 T273 EPSD|PSP DBF4 ASK DBF4A ZDBF1 FDVDKPssMQKQTQVKLRIQtDGDKYGGtsIQLQLKEKKKK
Q9UBU7 T281 EPSD|PSP DBF4 ASK DBF4A ZDBF1 MQKQTQVKLRIQtDGDKYGGtsIQLQLKEKKKKGYCECCLQ
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Chromatin organization R-HSA-4839726 8.405043e-11 10.075 0 0
Chromatin modifying enzymes R-HSA-3247509 1.514221e-09 8.820 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.081822e-09 8.511 0 0
Cell Cycle R-HSA-1640170 1.379052e-07 6.860 1 0
Cell Cycle, Mitotic R-HSA-69278 4.152501e-07 6.382 1 0
Apoptotic cleavage of cellular proteins R-HSA-111465 9.433120e-07 6.025 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 8.900887e-07 6.051 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.318882e-06 5.880 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.959574e-06 5.529 0 0
Signaling by ALK in cancer R-HSA-9700206 2.959574e-06 5.529 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 3.410608e-06 5.467 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 4.607970e-06 5.336 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.662774e-06 5.331 0 0
HATs acetylate histones R-HSA-3214847 1.026498e-05 4.989 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.406082e-05 4.852 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.116697e-05 4.674 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.852992e-05 4.545 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 3.178900e-05 4.498 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 4.311940e-05 4.365 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 4.311940e-05 4.365 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 4.567598e-05 4.340 0 0
snRNP Assembly R-HSA-191859 6.147082e-05 4.211 0 0
Metabolism of non-coding RNA R-HSA-194441 6.147082e-05 4.211 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 7.682747e-05 4.114 0 0
mRNA Splicing - Major Pathway R-HSA-72163 7.428682e-05 4.129 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 8.564565e-05 4.067 0 0
Apoptotic execution phase R-HSA-75153 9.465029e-05 4.024 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 1.017793e-04 3.992 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.010279e-04 3.996 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.103341e-04 3.957 0 0
Nuclear import of Rev protein R-HSA-180746 1.316203e-04 3.881 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.752695e-04 3.756 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.699645e-04 3.770 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.789171e-04 3.747 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.789171e-04 3.747 0 0
mRNA Splicing R-HSA-72172 2.246742e-04 3.648 0 0
HIV Life Cycle R-HSA-162587 2.695275e-04 3.569 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 3.226279e-04 3.491 0 0
Signaling by Hippo R-HSA-2028269 3.237860e-04 3.490 0 0
Epigenetic regulation of gene expression R-HSA-212165 3.639145e-04 3.439 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.638950e-04 3.439 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.638950e-04 3.439 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 4.360252e-04 3.360 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 4.360252e-04 3.360 0 0
PKMTs methylate histone lysines R-HSA-3214841 6.686786e-04 3.175 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.632203e-04 3.178 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 6.686786e-04 3.175 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.794940e-04 3.168 0 0
Estrogen-dependent gene expression R-HSA-9018519 7.312339e-04 3.136 0 0
Late Phase of HIV Life Cycle R-HSA-162599 7.873283e-04 3.104 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 8.547090e-04 3.068 0 0
M Phase R-HSA-68886 1.221884e-03 2.913 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.196419e-03 2.922 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.302536e-03 2.885 0 0
Cell Cycle Checkpoints R-HSA-69620 1.281046e-03 2.892 1 0
Regulation of TP53 Activity R-HSA-5633007 1.310270e-03 2.883 0 0
Regulation of TP53 Expression R-HSA-6804754 1.338421e-03 2.873 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 1.747690e-03 2.758 0 0
tRNA processing in the nucleus R-HSA-6784531 1.841764e-03 2.735 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.867070e-03 2.729 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.036056e-03 2.691 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 2.036056e-03 2.691 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.082972e-03 2.681 0 0
ISG15 antiviral mechanism R-HSA-1169408 2.243556e-03 2.649 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.495714e-03 2.603 0 0
MTOR signalling R-HSA-165159 2.683557e-03 2.571 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.983289e-03 2.525 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.142213e-03 2.503 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 3.177407e-03 2.498 0 0
Mitotic Anaphase R-HSA-68882 3.289031e-03 2.483 0 0
Mitotic Spindle Checkpoint R-HSA-69618 3.471417e-03 2.459 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.458314e-03 2.461 1 1
Mitotic Metaphase and Anaphase R-HSA-2555396 3.537051e-03 2.451 0 0
Viral Messenger RNA Synthesis R-HSA-168325 3.698280e-03 2.432 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.889026e-03 2.410 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 4.385480e-03 2.358 0 0
HIV Infection R-HSA-162906 4.397588e-03 2.357 0 0
Metabolism of RNA R-HSA-8953854 4.604948e-03 2.337 0 0
Mitotic Prophase R-HSA-68875 5.109479e-03 2.292 0 0
mRNA 3'-end processing R-HSA-72187 5.401689e-03 2.267 0 0
Cellular response to heat stress R-HSA-3371556 5.609672e-03 2.251 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 5.650048e-03 2.248 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 5.650048e-03 2.248 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 5.650048e-03 2.248 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 5.650048e-03 2.248 0 0
G0 and Early G1 R-HSA-1538133 5.745848e-03 2.241 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 6.183894e-03 2.209 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.926738e-03 2.159 1 0
Transcriptional regulation by small RNAs R-HSA-5578749 7.087630e-03 2.149 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 7.182831e-03 2.144 0 0
Gene expression (Transcription) R-HSA-74160 7.237572e-03 2.140 1 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.642268e-03 2.117 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.116962e-03 2.091 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 7.766652e-03 2.110 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 8.210875e-03 2.086 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 8.957634e-03 2.048 0 0
Heme signaling R-HSA-9707616 9.311779e-03 2.031 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 9.786460e-03 2.009 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 9.884524e-03 2.005 0 0
HDMs demethylate histones R-HSA-3214842 1.158956e-02 1.936 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 1.249345e-02 1.903 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.333046e-02 1.875 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.396154e-02 1.855 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.491395e-02 1.826 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.502041e-02 1.823 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.559383e-02 1.807 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.621647e-02 1.790 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.621647e-02 1.790 0 0
Signal Transduction R-HSA-162582 1.662234e-02 1.779 0 0
Specification of primordial germ cells R-HSA-9827857 1.570136e-02 1.804 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.764456e-02 1.753 0 0
Nuclear RNA decay R-HSA-9930044 1.764456e-02 1.753 0 0
mTORC1-mediated signalling R-HSA-166208 1.821104e-02 1.740 0 0
Cellular Senescence R-HSA-2559583 1.921275e-02 1.716 0 0
NRAGE signals death through JNK R-HSA-193648 1.994646e-02 1.700 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.312850e-02 1.636 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.312850e-02 1.636 0 0
SDK interactions R-HSA-373756 2.312850e-02 1.636 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.312850e-02 1.636 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.312850e-02 1.636 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.312850e-02 1.636 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.312850e-02 1.636 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.184557e-02 1.661 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.236128e-02 1.651 0 0
Rap1 signalling R-HSA-392517 2.379177e-02 1.624 0 0
Semaphorin interactions R-HSA-373755 2.154319e-02 1.667 0 0
S Phase R-HSA-69242 2.240869e-02 1.650 0 0
Inositol phosphate metabolism R-HSA-1483249 2.170275e-02 1.663 0 0
Glycolysis R-HSA-70171 2.272170e-02 1.644 0 0
Separation of Sister Chromatids R-HSA-2467813 2.529619e-02 1.597 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 2.599610e-02 1.585 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.614345e-02 1.583 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.723052e-02 1.565 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.046049e-02 1.516 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 3.111252e-02 1.507 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.228449e-02 1.491 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 3.228449e-02 1.491 0 0
XBP1(S) activates chaperone genes R-HSA-381038 3.253398e-02 1.488 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 3.371977e-02 1.472 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.530954e-02 1.452 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.388075e-02 1.470 0 0
Apoptosis R-HSA-109581 3.478667e-02 1.459 0 0
Host Interactions of HIV factors R-HSA-162909 3.658851e-02 1.437 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 4.081666e-02 1.389 0 0
Type I hemidesmosome assembly R-HSA-446107 4.081666e-02 1.389 0 0
Formation of annular gap junctions R-HSA-196025 4.081666e-02 1.389 0 0
Repression of WNT target genes R-HSA-4641265 4.066991e-02 1.391 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.066991e-02 1.391 0 0
Pervasive developmental disorders R-HSA-9005895 4.066991e-02 1.391 0 0
Disorders of Nervous System Development R-HSA-9697154 4.066991e-02 1.391 0 0
Disorders of Developmental Biology R-HSA-9675151 3.794479e-02 1.421 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 3.794479e-02 1.421 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.794479e-02 1.421 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.066991e-02 1.391 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.794479e-02 1.421 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 4.081666e-02 1.389 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.066707e-02 1.391 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.141537e-02 1.383 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.159574e-02 1.381 0 0
Gene Silencing by RNA R-HSA-211000 4.233121e-02 1.373 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.297249e-02 1.367 0 0
Circadian clock R-HSA-9909396 4.427782e-02 1.354 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 4.549539e-02 1.342 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 4.925633e-02 1.308 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 4.925633e-02 1.308 0 0
Formation of axial mesoderm R-HSA-9796292 5.025828e-02 1.299 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 5.025828e-02 1.299 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 4.566484e-02 1.340 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.714818e-02 1.327 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.136641e-02 1.289 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.862169e-02 1.313 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 4.573995e-02 1.340 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.841097e-02 1.315 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.925633e-02 1.308 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.925633e-02 1.308 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.825776e-02 1.316 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 4.793220e-02 1.319 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 5.025828e-02 1.299 0 0
IRE1alpha activates chaperones R-HSA-381070 5.259051e-02 1.279 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 5.293115e-02 1.276 0 0
Lipophagy R-HSA-9613354 5.293115e-02 1.276 0 0
Gap junction degradation R-HSA-190873 5.293115e-02 1.276 0 0
Calcineurin activates NFAT R-HSA-2025928 5.293115e-02 1.276 0 0
ALK mutants bind TKIs R-HSA-9700645 5.293115e-02 1.276 0 0
Unwinding of DNA R-HSA-176974 5.293115e-02 1.276 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 5.338417e-02 1.273 0 0
Ephrin signaling R-HSA-3928664 5.429413e-02 1.265 0 0
Polo-like kinase mediated events R-HSA-156711 5.429413e-02 1.265 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.489834e-02 1.260 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 5.569300e-02 1.254 0 0
EPH-Ephrin signaling R-HSA-2682334 5.662960e-02 1.247 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.106213e-02 1.214 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 6.106213e-02 1.214 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.106213e-02 1.214 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.395414e-02 1.194 0 0
HIV Transcription Initiation R-HSA-167161 6.395414e-02 1.194 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.395414e-02 1.194 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 6.667367e-02 1.176 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 6.240681e-02 1.205 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 6.106213e-02 1.214 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.855582e-02 1.232 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.667367e-02 1.176 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.059856e-02 1.218 0 0
Neurodegenerative Diseases R-HSA-8863678 6.386930e-02 1.195 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.386930e-02 1.195 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 6.678403e-02 1.175 0 0
Nervous system development R-HSA-9675108 6.714872e-02 1.173 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 6.738212e-02 1.171 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 6.738212e-02 1.171 0 0
RUNX2 regulates bone development R-HSA-8941326 6.740750e-02 1.171 0 0
RET signaling R-HSA-8853659 6.740750e-02 1.171 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 6.767401e-02 1.170 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.767401e-02 1.170 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 6.767401e-02 1.170 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.767401e-02 1.170 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 6.767401e-02 1.170 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.767401e-02 1.170 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 6.977073e-02 1.156 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 6.977073e-02 1.156 0 0
Signaling by NOTCH1 R-HSA-1980143 7.078618e-02 1.150 0 0
Unfolded Protein Response (UPR) R-HSA-381119 7.116481e-02 1.148 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 7.961949e-02 1.099 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 7.307747e-02 1.136 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 7.307747e-02 1.136 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.303061e-02 1.081 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 7.836934e-02 1.106 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 7.631279e-02 1.117 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 8.222465e-02 1.085 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 7.432019e-02 1.129 0 0
Formation of definitive endoderm R-HSA-9823730 7.432019e-02 1.129 0 0
PCP/CE pathway R-HSA-4086400 8.222465e-02 1.085 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 7.530467e-02 1.123 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 8.303061e-02 1.081 0 0
G alpha (12/13) signalling events R-HSA-416482 8.222465e-02 1.085 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.171167e-02 1.088 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 7.493129e-02 1.125 0 0
Programmed Cell Death R-HSA-5357801 7.744554e-02 1.111 0 0
Cell-extracellular matrix interactions R-HSA-446353 7.307747e-02 1.136 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 7.589634e-02 1.120 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.571415e-02 1.067 0 0
Phosphorylation of the APC/C R-HSA-176412 8.628471e-02 1.064 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.628471e-02 1.064 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 8.628471e-02 1.064 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.628471e-02 1.064 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 8.874093e-02 1.052 0 0
Cellular responses to stimuli R-HSA-8953897 9.055116e-02 1.043 0 0
Cell junction organization R-HSA-446728 9.095689e-02 1.041 0 0
Glucose metabolism R-HSA-70326 9.130486e-02 1.040 0 0
Signaling by ALK R-HSA-201556 9.240780e-02 1.034 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 9.369328e-02 1.028 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 9.372135e-02 1.028 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 9.372135e-02 1.028 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.464105e-02 1.024 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 9.464105e-02 1.024 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 9.478952e-02 1.023 0 0
Switching of origins to a post-replicative state R-HSA-69052 9.564353e-02 1.019 0 0
Mitotic G2-G2/M phases R-HSA-453274 9.583603e-02 1.018 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 9.584389e-02 1.018 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.096415e-01 0.960 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.096415e-01 0.960 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.096415e-01 0.960 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.096415e-01 0.960 0 0
Signaling by FGFR1 amplification mutants R-HSA-1839120 1.155464e-01 0.937 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.155464e-01 0.937 0 0
MET interacts with TNS proteins R-HSA-8875513 1.155464e-01 0.937 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.121702e-01 0.950 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.121702e-01 0.950 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.121702e-01 0.950 0 0
TRIF-mediated programmed cell death R-HSA-2562578 1.121702e-01 0.950 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 1.121702e-01 0.950 0 0
Signaling by AMER1 mutants R-HSA-4839748 9.946798e-02 1.002 0 0
Notch-HLH transcription pathway R-HSA-350054 1.111921e-01 0.954 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.041669e-01 0.982 0 0
Transcription of the HIV genome R-HSA-167172 1.113987e-01 0.953 0 0
Integration of provirus R-HSA-162592 9.946798e-02 1.002 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 9.629179e-02 1.016 0 0
ESR-mediated signaling R-HSA-8939211 1.120450e-01 0.951 0 0
Protein ubiquitination R-HSA-8852135 1.100697e-01 0.958 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 9.946798e-02 1.002 0 0
Cellular responses to stress R-HSA-2262752 9.778240e-02 1.010 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.155464e-01 0.937 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 9.801230e-02 1.009 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 9.875626e-02 1.005 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.801230e-02 1.009 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 1.121702e-01 0.950 0 0
Macroautophagy R-HSA-1632852 1.159946e-01 0.936 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 1.181167e-01 0.928 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.181167e-01 0.928 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.181167e-01 0.928 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.181167e-01 0.928 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.193908e-01 0.923 0 0
Autophagy R-HSA-9612973 1.203933e-01 0.919 0 0
Oncogene Induced Senescence R-HSA-2559585 1.206045e-01 0.919 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.213525e-01 0.916 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.221570e-01 0.913 0 0
Deubiquitination R-HSA-5688426 1.223662e-01 0.912 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.227967e-01 0.911 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.072674e-01 0.683 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.072674e-01 0.683 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.072674e-01 0.683 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.072674e-01 0.683 0 0
TICAM1 deficiency - HSE R-HSA-5602566 2.072674e-01 0.683 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 1.546615e-01 0.811 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.546615e-01 0.811 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.941939e-01 0.531 0 0
Defective MMADHC causes MMAHCD R-HSA-3359473 2.941939e-01 0.531 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.941939e-01 0.531 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.941939e-01 0.531 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.941939e-01 0.531 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 1.958347e-01 0.708 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 1.958347e-01 0.708 0 0
IRS activation R-HSA-74713 1.958347e-01 0.708 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 1.958347e-01 0.708 0 0
G2 Phase R-HSA-68911 1.958347e-01 0.708 0 0
NOSIP mediated eNOS trafficking R-HSA-203754 1.958347e-01 0.708 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.958347e-01 0.708 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 1.376593e-01 0.861 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 1.376593e-01 0.861 0 0
GP1b-IX-V activation signalling R-HSA-430116 1.648862e-01 0.783 0 0
WNT mediated activation of DVL R-HSA-201688 1.648862e-01 0.783 0 0
Signaling by MST1 R-HSA-8852405 2.381451e-01 0.623 0 0
Signaling by RNF43 mutants R-HSA-5340588 2.381451e-01 0.623 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.715931e-01 0.430 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.715931e-01 0.430 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.715931e-01 0.430 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.715931e-01 0.430 0 0
Defective F8 cleavage by thrombin R-HSA-9672391 3.715931e-01 0.430 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.715931e-01 0.430 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.715931e-01 0.430 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.715931e-01 0.430 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.715931e-01 0.430 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 3.715931e-01 0.430 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.715931e-01 0.430 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.715931e-01 0.430 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.715931e-01 0.430 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.715931e-01 0.430 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.715931e-01 0.430 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.715931e-01 0.430 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.715931e-01 0.430 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.715931e-01 0.430 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.715931e-01 0.430 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.715931e-01 0.430 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.381488e-01 0.860 0 0
2-LTR circle formation R-HSA-164843 1.935312e-01 0.713 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 1.935312e-01 0.713 0 0
Signaling by LTK in cancer R-HSA-9842640 2.808488e-01 0.552 0 0
Erythropoietin activates STAT5 R-HSA-9027283 2.808488e-01 0.552 0 0
PKA activation R-HSA-163615 1.326572e-01 0.877 0 0
PECAM1 interactions R-HSA-210990 2.232834e-01 0.651 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 2.232834e-01 0.651 0 0
Signaling by APC mutants R-HSA-4839744 2.232834e-01 0.651 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 2.232834e-01 0.651 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 2.232834e-01 0.651 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 2.232834e-01 0.651 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.501739e-01 0.823 0 0
Deadenylation of mRNA R-HSA-429947 1.400701e-01 0.854 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 2.538473e-01 0.595 0 0
NF-kB is activated and signals survival R-HSA-209560 2.538473e-01 0.595 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.538473e-01 0.595 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.233514e-01 0.490 0 0
IFNG signaling activates MAPKs R-HSA-9732724 3.233514e-01 0.490 0 0
SOS-mediated signalling R-HSA-112412 3.233514e-01 0.490 0 0
Disinhibition of SNARE formation R-HSA-114516 3.233514e-01 0.490 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.405087e-01 0.356 0 0
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336 4.405087e-01 0.356 0 0
Defective MMACHC causes MAHCC R-HSA-3359474 4.405087e-01 0.356 0 0
Invadopodia formation R-HSA-8941237 4.405087e-01 0.356 0 0
MET activates PTPN11 R-HSA-8865999 4.405087e-01 0.356 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.405087e-01 0.356 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.405087e-01 0.356 0 0
Activation of the pre-replicative complex R-HSA-68962 1.300951e-01 0.886 1 1
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 1.300951e-01 0.886 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 2.849467e-01 0.545 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.849467e-01 0.545 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.849467e-01 0.545 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.849467e-01 0.545 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.849467e-01 0.545 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.849467e-01 0.545 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.849467e-01 0.545 0 0
G1/S-Specific Transcription R-HSA-69205 1.324119e-01 0.878 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.447857e-01 0.839 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.890460e-01 0.723 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 2.541347e-01 0.595 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.651837e-01 0.437 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.651837e-01 0.437 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 3.163278e-01 0.500 0 0
PKA activation in glucagon signalling R-HSA-164378 2.794580e-01 0.554 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 1.299407e-01 0.886 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 1.816295e-01 0.741 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.714134e-01 0.566 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.059820e-01 0.391 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 5.018701e-01 0.299 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 5.018701e-01 0.299 0 0
Signaling by MAP2K mutants R-HSA-9652169 5.018701e-01 0.299 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 5.018701e-01 0.299 0 0
MAP2K and MAPK activation R-HSA-5674135 2.143280e-01 0.669 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.143280e-01 0.669 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.143280e-01 0.669 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.143280e-01 0.669 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.143280e-01 0.669 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.735607e-01 0.761 0 0
Translation initiation complex formation R-HSA-72649 1.899677e-01 0.721 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.310723e-01 0.480 0 0
HDACs deacetylate histones R-HSA-3214815 2.025764e-01 0.693 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.799348e-01 0.745 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.790402e-01 0.421 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.790402e-01 0.421 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.790402e-01 0.421 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.790402e-01 0.421 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.790402e-01 0.421 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.155289e-01 0.666 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.158320e-01 0.501 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.909101e-01 0.719 0 0
Regulation of CDH1 Function R-HSA-9764561 2.288047e-01 0.641 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 4.454701e-01 0.351 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 4.454701e-01 0.351 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.454701e-01 0.351 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.137462e-01 0.670 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.423825e-01 0.615 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 3.383872e-01 0.471 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 3.383872e-01 0.471 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.383872e-01 0.471 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.383872e-01 0.471 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 2.664499e-01 0.574 0 0
Striated Muscle Contraction R-HSA-390522 3.219590e-01 0.492 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 2.178158e-01 0.662 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.939040e-01 0.532 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.939040e-01 0.532 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.939040e-01 0.532 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.939040e-01 0.532 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.816647e-01 0.550 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 2.816647e-01 0.550 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 2.816647e-01 0.550 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 2.211472e-01 0.655 0 0
HIV elongation arrest and recovery R-HSA-167287 3.610594e-01 0.442 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.610594e-01 0.442 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.421703e-01 0.466 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 3.106443e-01 0.508 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 3.127611e-01 0.505 0 0
PERK regulates gene expression R-HSA-381042 3.625014e-01 0.441 0 0
Late endosomal microautophagy R-HSA-9615710 3.837679e-01 0.416 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.837679e-01 0.416 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 4.089887e-01 0.388 0 0
FGFR2 alternative splicing R-HSA-6803529 4.089887e-01 0.388 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.834447e-01 0.316 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 5.565050e-01 0.255 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.565050e-01 0.255 0 0
FGFR1c and Klotho ligand binding and activation R-HSA-190374 5.565050e-01 0.255 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.565050e-01 0.255 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.565050e-01 0.255 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.565050e-01 0.255 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.467257e-01 0.608 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.661562e-01 0.575 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 2.882958e-01 0.540 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 3.285831e-01 0.483 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.285831e-01 0.483 0 0
Degradation of CDH1 R-HSA-9766229 3.446563e-01 0.463 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 3.606251e-01 0.443 0 0
Dual incision in TC-NER R-HSA-6782135 3.606251e-01 0.443 0 0
Degradation of DVL R-HSA-4641258 4.032904e-01 0.394 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.702620e-01 0.328 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.417160e-01 0.466 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 3.964562e-01 0.402 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.197631e-01 0.284 0 0
Activation of RAC1 R-HSA-428540 5.197631e-01 0.284 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.197631e-01 0.284 0 0
Signaling by activated point mutants of FGFR1 R-HSA-1839122 5.197631e-01 0.284 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.197631e-01 0.284 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.197631e-01 0.284 0 0
Meiotic synapsis R-HSA-1221632 4.137901e-01 0.383 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.137901e-01 0.383 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 4.993463e-01 0.302 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 4.993463e-01 0.302 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.639823e-01 0.333 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.416910e-01 0.355 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.416910e-01 0.355 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 5.275961e-01 0.278 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.275961e-01 0.278 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 5.275961e-01 0.278 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 6.051504e-01 0.218 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.051504e-01 0.218 0 0
Plus-strand DNA synthesis R-HSA-164525 6.051504e-01 0.218 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 6.051504e-01 0.218 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 6.051504e-01 0.218 0 0
Cam-PDE 1 activation R-HSA-111957 6.051504e-01 0.218 0 0
Phosphorylation of Emi1 R-HSA-176417 6.051504e-01 0.218 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 6.051504e-01 0.218 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.051504e-01 0.218 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.051504e-01 0.218 0 0
Signaling by MAPK mutants R-HSA-9652817 6.051504e-01 0.218 0 0
Dual Incision in GG-NER R-HSA-5696400 5.168382e-01 0.287 0 0
AURKA Activation by TPX2 R-HSA-8854518 4.898918e-01 0.310 0 0
HCMV Early Events R-HSA-9609690 4.444673e-01 0.352 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 4.963308e-01 0.304 0 0
Co-inhibition by CTLA4 R-HSA-389513 5.549357e-01 0.256 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 5.549357e-01 0.256 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 5.549357e-01 0.256 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 5.549357e-01 0.256 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 5.549357e-01 0.256 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.565695e-01 0.254 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.565695e-01 0.254 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.565695e-01 0.254 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.565695e-01 0.254 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 5.870976e-01 0.231 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 5.870976e-01 0.231 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.870976e-01 0.231 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.870976e-01 0.231 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 5.870976e-01 0.231 0 0
PPARA activates gene expression R-HSA-1989781 5.382445e-01 0.269 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.792433e-01 0.237 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.969981e-01 0.224 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.971190e-01 0.224 0 0
DAP12 signaling R-HSA-2424491 6.012382e-01 0.221 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.066636e-01 0.217 0 0
Removal of the Flap Intermediate R-HSA-69166 6.180403e-01 0.209 0 0
Retrograde neurotrophin signalling R-HSA-177504 6.180403e-01 0.209 0 0
Centrosome maturation R-HSA-380287 6.255635e-01 0.204 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 6.114669e-01 0.214 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.366670e-01 0.626 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.021850e-01 0.694 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 4.696701e-01 0.328 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 3.646030e-01 0.438 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.355694e-01 0.361 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.355694e-01 0.361 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.878583e-01 0.726 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 3.646030e-01 0.438 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 3.646030e-01 0.438 0 0
Nucleotide Excision Repair R-HSA-5696398 1.438811e-01 0.842 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.502521e-01 0.602 0 0
HIV Transcription Elongation R-HSA-167169 4.639823e-01 0.333 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.327925e-01 0.273 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.281610e-01 0.484 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.525976e-01 0.598 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.541347e-01 0.595 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.310723e-01 0.480 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.897227e-01 0.722 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.873071e-01 0.727 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 1.878583e-01 0.726 0 0
TGFBR3 expression R-HSA-9839394 1.556888e-01 0.808 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 3.163278e-01 0.500 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.639823e-01 0.333 0 0
Hedgehog 'off' state R-HSA-5610787 5.251097e-01 0.280 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 1.326572e-01 0.877 0 0
Aggrephagy R-HSA-9646399 3.072522e-01 0.513 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.902846e-01 0.721 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.829266e-01 0.417 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.224887e-01 0.653 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.224887e-01 0.653 0 0
FOXO-mediated transcription R-HSA-9614085 3.015924e-01 0.521 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.878583e-01 0.726 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.992556e-01 0.524 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 4.089887e-01 0.388 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 4.355694e-01 0.361 0 0
Frs2-mediated activation R-HSA-170968 3.163278e-01 0.500 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.794580e-01 0.554 0 0
DARPP-32 events R-HSA-180024 3.837679e-01 0.416 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.599701e-01 0.337 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.735074e-01 0.325 0 0
COPI-mediated anterograde transport R-HSA-6807878 5.866426e-01 0.232 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.336884e-01 0.874 0 0
Cyclin D associated events in G1 R-HSA-69231 1.564446e-01 0.806 0 0
G1 Phase R-HSA-69236 1.564446e-01 0.806 0 0
Interleukin-15 signaling R-HSA-8983432 5.543318e-01 0.256 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.293218e-01 0.640 0 0
Germ layer formation at gastrulation R-HSA-9754189 5.275961e-01 0.278 0 0
Homology Directed Repair R-HSA-5693538 4.656913e-01 0.332 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.309772e-01 0.200 0 0
Meiosis R-HSA-1500620 3.967850e-01 0.401 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 1.546615e-01 0.811 0 0
PI3K/AKT activation R-HSA-198203 1.935312e-01 0.713 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.233514e-01 0.490 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.850832e-01 0.733 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.059820e-01 0.391 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.197631e-01 0.284 0 0
Stabilization of p53 R-HSA-69541 4.438845e-01 0.353 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.438845e-01 0.353 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.051504e-01 0.218 0 0
Pyroptosis R-HSA-5620971 5.565695e-01 0.254 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.965035e-01 0.304 0 0
G1/S Transition R-HSA-69206 2.053240e-01 0.688 1 0
Myogenesis R-HSA-525793 1.720316e-01 0.764 0 0
Recycling pathway of L1 R-HSA-437239 3.106443e-01 0.508 0 0
Killing mechanisms R-HSA-9664420 2.051666e-01 0.688 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 2.051666e-01 0.688 0 0
Signaling by RAS mutants R-HSA-6802949 2.939040e-01 0.532 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 3.106443e-01 0.508 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.278994e-01 0.277 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.791438e-01 0.237 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.019987e-01 0.695 0 0
Adherens junctions interactions R-HSA-418990 2.253079e-01 0.647 0 0
Cell-cell junction organization R-HSA-421270 2.301318e-01 0.638 0 0
Adipogenesis R-HSA-9843745 3.510962e-01 0.455 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.648862e-01 0.783 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 2.381451e-01 0.623 0 0
Signaling by WNT in cancer R-HSA-4791275 1.577143e-01 0.802 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.059820e-01 0.391 0 0
Regulation of gap junction activity R-HSA-191650 5.018701e-01 0.299 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.837679e-01 0.416 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.768431e-01 0.558 0 0
Trafficking of AMPA receptors R-HSA-399719 4.289928e-01 0.368 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.438845e-01 0.353 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 5.543318e-01 0.256 0 0
RAF activation R-HSA-5673000 5.168382e-01 0.287 0 0
Budding and maturation of HIV virion R-HSA-162588 6.225236e-01 0.206 0 0
RNA Polymerase II Transcription R-HSA-73857 2.403148e-01 0.619 1 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.964562e-01 0.402 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.287078e-01 0.483 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.093456e-01 0.293 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.309772e-01 0.200 0 0
Generic Transcription Pathway R-HSA-212436 5.936499e-01 0.226 1 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.508625e-01 0.346 0 0
Lagging Strand Synthesis R-HSA-69186 5.813062e-01 0.236 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.093456e-01 0.293 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 5.881573e-01 0.231 0 0
Activation of HOX genes during differentiation R-HSA-5619507 5.881573e-01 0.231 0 0
FGFR1 mutant receptor activation R-HSA-1839124 1.724480e-01 0.763 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 5.420309e-01 0.266 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 4.099847e-01 0.387 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 5.012238e-01 0.300 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.477003e-01 0.831 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.791330e-01 0.421 0 0
Cell-Cell communication R-HSA-1500931 1.475094e-01 0.831 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.326572e-01 0.877 0 0
Prolonged ERK activation events R-HSA-169893 4.099847e-01 0.387 0 0
Mitotic Prometaphase R-HSA-68877 1.604989e-01 0.795 0 0
PTEN Regulation R-HSA-6807070 2.078982e-01 0.682 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 6.114669e-01 0.214 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.726794e-01 0.763 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.958347e-01 0.708 0 0
DCC mediated attractive signaling R-HSA-418885 1.818193e-01 0.740 0 0
DNA strand elongation R-HSA-69190 1.577143e-01 0.802 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.651837e-01 0.437 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.724480e-01 0.763 1 1
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 3.163278e-01 0.500 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.059820e-01 0.391 0 0
DNA Double Strand Break Response R-HSA-5693606 1.692710e-01 0.771 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.021850e-01 0.694 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 4.404370e-01 0.356 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.625805e-01 0.441 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 4.993463e-01 0.302 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.953471e-01 0.305 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.168382e-01 0.287 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.290618e-01 0.367 0 0
MET promotes cell motility R-HSA-8875878 5.984706e-01 0.223 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.075048e-01 0.390 0 0
Signaling by WNT R-HSA-195721 1.381752e-01 0.860 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 5.549357e-01 0.256 0 0
Signaling by NOTCH3 R-HSA-9012852 2.025764e-01 0.693 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 3.139949e-01 0.503 0 0
DNA Repair R-HSA-73894 2.042141e-01 0.690 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.255798e-01 0.647 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 2.664499e-01 0.574 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.294485e-01 0.888 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.479071e-01 0.606 1 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.543318e-01 0.256 0 0
p75NTR signals via NF-kB R-HSA-193639 3.790402e-01 0.421 0 0
PIP3 activates AKT signaling R-HSA-1257604 2.514564e-01 0.600 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.311632e-01 0.882 0 0
Selective autophagy R-HSA-9663891 3.403002e-01 0.468 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.381451e-01 0.623 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 5.018701e-01 0.299 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 3.767859e-01 0.424 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.051504e-01 0.218 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.791438e-01 0.237 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.309772e-01 0.200 0 0
Signaling by Hedgehog R-HSA-5358351 6.257835e-01 0.204 0 0
Synthesis of DNA R-HSA-69239 2.279542e-01 0.642 0 0
DNA Replication R-HSA-69306 5.174762e-01 0.286 1 0
Mismatch Repair R-HSA-5358508 2.794580e-01 0.554 0 0
G2/M Checkpoints R-HSA-69481 1.599205e-01 0.796 1 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.491266e-01 0.260 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 3.878912e-01 0.411 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.291799e-01 0.640 0 0
Membrane Trafficking R-HSA-199991 1.536743e-01 0.813 0 0
G2/M Transition R-HSA-69275 1.655917e-01 0.781 0 0
Co-inhibition by PD-1 R-HSA-389948 3.300983e-01 0.481 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.735607e-01 0.761 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.735607e-01 0.761 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.735607e-01 0.761 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.735607e-01 0.761 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 4.404370e-01 0.356 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 5.791438e-01 0.237 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.890460e-01 0.723 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.792433e-01 0.237 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.565922e-01 0.805 0 0
TCR signaling R-HSA-202403 5.536641e-01 0.257 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.292942e-01 0.888 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 2.541347e-01 0.595 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 4.404370e-01 0.356 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 2.538308e-01 0.595 0 0
NGF-stimulated transcription R-HSA-9031628 2.084894e-01 0.681 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.543318e-01 0.256 0 0
Nephrin family interactions R-HSA-373753 5.549357e-01 0.256 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.066636e-01 0.217 0 0
G-protein mediated events R-HSA-112040 5.057355e-01 0.296 0 0
Apoptotic factor-mediated response R-HSA-111471 4.993463e-01 0.302 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 4.661010e-01 0.332 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.303661e-01 0.275 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 3.625014e-01 0.441 0 0
Signaling by NOTCH R-HSA-157118 3.945056e-01 0.404 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 3.287078e-01 0.483 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.994873e-01 0.700 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.073510e-01 0.390 0 0
Signaling by FGFR in disease R-HSA-1226099 3.572945e-01 0.447 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.941939e-01 0.531 0 0
Reelin signalling pathway R-HSA-8866376 1.958347e-01 0.708 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 1.648862e-01 0.783 0 0
tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis R-HSA-9708296 3.715931e-01 0.430 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.715931e-01 0.430 0 0
Defective factor XII causes hereditary angioedema R-HSA-9657688 3.715931e-01 0.430 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.381488e-01 0.860 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.935312e-01 0.713 0 0
Signaling by AXIN mutants R-HSA-4839735 2.538473e-01 0.595 0 0
Interleukin-7 signaling R-HSA-1266695 1.556888e-01 0.808 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 1.447857e-01 0.839 0 0
Ovarian tumor domain proteases R-HSA-5689896 1.447857e-01 0.839 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.794580e-01 0.554 0 0
Regulation of KIT signaling R-HSA-1433559 3.477608e-01 0.459 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.059820e-01 0.391 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 5.018701e-01 0.299 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 5.018701e-01 0.299 0 0
GABA synthesis R-HSA-888568 5.018701e-01 0.299 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.219590e-01 0.492 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.805682e-01 0.743 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 2.971117e-01 0.527 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 5.565050e-01 0.255 0 0
Cellular response to hypoxia R-HSA-1234174 3.439262e-01 0.464 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 4.702620e-01 0.328 0 0
Orc1 removal from chromatin R-HSA-68949 3.964562e-01 0.402 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 5.197631e-01 0.284 0 0
Presynaptic function of Kainate receptors R-HSA-500657 4.993463e-01 0.302 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 4.202434e-01 0.376 0 0
Metalloprotease DUBs R-HSA-5689901 5.093456e-01 0.293 0 0
Signaling by NOTCH4 R-HSA-9013694 6.114136e-01 0.214 0 0
MHC class II antigen presentation R-HSA-2132295 6.247715e-01 0.204 0 0
MAPK family signaling cascades R-HSA-5683057 4.361554e-01 0.360 0 0
Rab regulation of trafficking R-HSA-9007101 2.687746e-01 0.571 0 0
GPVI-mediated activation cascade R-HSA-114604 2.366670e-01 0.626 0 0
Signaling by EGFR R-HSA-177929 2.155289e-01 0.666 0 0
Assembly of the pre-replicative complex R-HSA-68867 2.238801e-01 0.650 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.546605e-01 0.811 0 0
Axon guidance R-HSA-422475 1.360633e-01 0.866 0 0
Signaling by MET R-HSA-6806834 4.444391e-01 0.352 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.035541e-01 0.298 0 0
Signaling by FGFR4 in disease R-HSA-5655291 6.180403e-01 0.209 0 0
Sema4D in semaphorin signaling R-HSA-400685 1.556888e-01 0.808 0 0
Regulation of beta-cell development R-HSA-186712 2.562398e-01 0.591 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.818193e-01 0.740 0 0
EGFR downregulation R-HSA-182971 4.289928e-01 0.368 0 0
Reproduction R-HSA-1474165 3.404858e-01 0.468 0 0
RMTs methylate histone arginines R-HSA-3214858 5.607726e-01 0.251 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.091506e-01 0.510 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 4.059820e-01 0.391 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.821398e-01 0.550 0 0
Ca2+ pathway R-HSA-4086398 4.661010e-01 0.332 0 0
IRS-mediated signalling R-HSA-112399 4.825843e-01 0.316 0 0
Calmodulin induced events R-HSA-111933 2.366670e-01 0.626 0 0
Signal attenuation R-HSA-74749 4.454701e-01 0.351 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.732301e-01 0.563 0 0
TBC/RABGAPs R-HSA-8854214 3.812310e-01 0.419 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.674914e-01 0.435 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 3.635177e-01 0.439 0 0
Regulation of signaling by CBL R-HSA-912631 5.275961e-01 0.278 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.735074e-01 0.325 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.999111e-01 0.398 0 0
Neurexins and neuroligins R-HSA-6794361 5.457274e-01 0.263 0 0
CaM pathway R-HSA-111997 2.366670e-01 0.626 0 0
Negative regulation of MET activity R-HSA-6807004 3.310723e-01 0.480 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 6.225236e-01 0.206 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.309772e-01 0.200 0 0
Signaling by ERBB2 R-HSA-1227986 5.327925e-01 0.273 0 0
IGF1R signaling cascade R-HSA-2428924 5.966244e-01 0.224 0 0
Signaling by VEGF R-HSA-194138 2.053240e-01 0.688 0 0
PLC beta mediated events R-HSA-112043 4.092420e-01 0.388 0 0
PI Metabolism R-HSA-1483255 2.467257e-01 0.608 0 0
Gastrulation R-HSA-9758941 2.332875e-01 0.632 0 0
Interleukin-1 processing R-HSA-448706 1.648862e-01 0.783 0 0
Processing of SMDT1 R-HSA-8949664 3.163278e-01 0.500 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.326047e-01 0.877 0 0
Signaling by LTK R-HSA-9842663 5.543318e-01 0.256 0 0
Signaling by ROBO receptors R-HSA-376176 5.093082e-01 0.293 0 0
Insulin receptor signalling cascade R-HSA-74751 5.966244e-01 0.224 0 0
DAG and IP3 signaling R-HSA-1489509 2.773901e-01 0.557 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 5.792433e-01 0.237 0 0
Potential therapeutics for SARS R-HSA-9679191 5.769198e-01 0.239 0 0
Signaling by NTRKs R-HSA-166520 3.766468e-01 0.424 0 0
Cardiogenesis R-HSA-9733709 3.019282e-01 0.520 0 0
Ca-dependent events R-HSA-111996 3.625805e-01 0.441 0 0
L1CAM interactions R-HSA-373760 3.448242e-01 0.462 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 6.118958e-01 0.213 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 1.326572e-01 0.877 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.435857e-01 0.843 0 0
Kinesins R-HSA-983189 3.930010e-01 0.406 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 1.878583e-01 0.726 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.639823e-01 0.333 0 0
Diseases of programmed cell death R-HSA-9645723 4.523539e-01 0.345 0 0
Signaling by KIT in disease R-HSA-9669938 6.309772e-01 0.200 0 0
Death Receptor Signaling R-HSA-73887 2.096813e-01 0.678 0 0
Josephin domain DUBs R-HSA-5689877 1.935312e-01 0.713 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.405087e-01 0.356 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.405087e-01 0.356 0 0
OAS antiviral response R-HSA-8983711 2.849467e-01 0.545 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 3.570984e-01 0.447 0 0
Regulation of the apoptosome activity R-HSA-9627069 4.454701e-01 0.351 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 4.454701e-01 0.351 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.099847e-01 0.387 0 0
Signaling by PDGFR in disease R-HSA-9671555 3.831076e-01 0.417 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.971117e-01 0.527 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.702620e-01 0.328 0 0
G2/M DNA damage checkpoint R-HSA-69473 3.572945e-01 0.447 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.197631e-01 0.284 0 0
Plasma lipoprotein clearance R-HSA-8964043 4.438845e-01 0.353 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 4.371930e-01 0.359 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.735074e-01 0.325 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.735074e-01 0.325 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.051504e-01 0.218 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.332549e-01 0.273 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 6.180403e-01 0.209 0 0
Signaling by TGFB family members R-HSA-9006936 5.005963e-01 0.301 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.501739e-01 0.823 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.182460e-01 0.661 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.735607e-01 0.761 0 0
Sensory processing of sound R-HSA-9659379 3.147272e-01 0.502 0 0
Regulation of PTEN stability and activity R-HSA-8948751 5.629980e-01 0.249 0 0
Signaling by TGFBR3 R-HSA-9839373 5.971190e-01 0.224 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 4.963308e-01 0.304 0 0
LDL clearance R-HSA-8964038 4.089887e-01 0.388 0 0
Interleukin-12 family signaling R-HSA-447115 5.580873e-01 0.253 0 0
Other interleukin signaling R-HSA-449836 5.275961e-01 0.278 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 5.229474e-01 0.282 0 0
Neurofascin interactions R-HSA-447043 2.808488e-01 0.552 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.808488e-01 0.552 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.790402e-01 0.421 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.309772e-01 0.200 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.415052e-01 0.617 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 4.775781e-01 0.321 0 0
Interleukin-12 signaling R-HSA-9020591 3.862220e-01 0.413 0 0
Specification of the neural plate border R-HSA-9834899 3.051493e-01 0.515 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 2.664499e-01 0.574 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.982018e-01 0.525 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.715931e-01 0.430 0 0
Regulation of PTEN localization R-HSA-8948747 3.233514e-01 0.490 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.405087e-01 0.356 0 0
Sodium/Proton exchangers R-HSA-425986 3.651837e-01 0.437 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 4.059820e-01 0.391 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 5.018701e-01 0.299 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 4.099847e-01 0.387 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 5.565050e-01 0.255 0 0
Mitochondrial biogenesis R-HSA-1592230 3.561231e-01 0.448 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.051504e-01 0.218 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 6.051504e-01 0.218 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.870976e-01 0.231 0 0
Triglyceride catabolism R-HSA-163560 5.585952e-01 0.253 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 4.589531e-01 0.338 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.818193e-01 0.740 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 3.233514e-01 0.490 0 0
FasL/ CD95L signaling R-HSA-75157 4.405087e-01 0.356 0 0
Formation of apoptosome R-HSA-111458 4.454701e-01 0.351 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.051504e-01 0.218 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.180403e-01 0.209 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.794580e-01 0.554 0 0
Cytoprotection by HMOX1 R-HSA-9707564 6.113040e-01 0.214 0 0
Insulin processing R-HSA-264876 5.332549e-01 0.273 0 0
Influenza Infection R-HSA-168255 5.276832e-01 0.278 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 4.834447e-01 0.316 0 0
PI3K Cascade R-HSA-109704 3.618546e-01 0.441 0 0
TRAIL signaling R-HSA-75158 6.051504e-01 0.218 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 3.999111e-01 0.398 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 6.051504e-01 0.218 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.439262e-01 0.464 0 0
SARS-CoV Infections R-HSA-9679506 5.116509e-01 0.291 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.285831e-01 0.483 0 0
HDL assembly R-HSA-8963896 3.477608e-01 0.459 0 0
The NLRP3 inflammasome R-HSA-844456 5.275961e-01 0.278 0 0
Signaling by Leptin R-HSA-2586552 4.454701e-01 0.351 0 0
tRNA processing R-HSA-72306 6.098182e-01 0.215 0 0
Interleukin-37 signaling R-HSA-9008059 6.012382e-01 0.221 0 0
Co-stimulation by CD28 R-HSA-389356 6.317954e-01 0.199 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.358632e-01 0.197 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 6.362344e-01 0.196 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 6.362344e-01 0.196 0 0
Diseases of Immune System R-HSA-5260271 6.362344e-01 0.196 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.362344e-01 0.196 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.379652e-01 0.195 0 0
UCH proteinases R-HSA-5689603 6.394363e-01 0.194 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.430759e-01 0.192 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 6.461850e-01 0.190 0 0
HCMV Late Events R-HSA-9610379 6.463596e-01 0.190 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.471654e-01 0.189 0 0
Erythropoietin activates RAS R-HSA-9027284 6.471654e-01 0.189 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 6.471654e-01 0.189 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 6.471654e-01 0.189 0 0
Translesion synthesis by REV1 R-HSA-110312 6.471654e-01 0.189 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 6.471654e-01 0.189 0 0
DNA Damage Reversal R-HSA-73942 6.471654e-01 0.189 0 0
Protein methylation R-HSA-8876725 6.471654e-01 0.189 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.471654e-01 0.189 0 0
Other semaphorin interactions R-HSA-416700 6.471654e-01 0.189 0 0
DNA Damage Bypass R-HSA-73893 6.484611e-01 0.188 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.484626e-01 0.188 0 0
Uncoating of the HIV Virion R-HSA-162585 6.484626e-01 0.188 0 0
Autointegration results in viral DNA circles R-HSA-177539 6.484626e-01 0.188 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.484626e-01 0.188 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.484626e-01 0.188 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.484626e-01 0.188 0 0
CREB phosphorylation R-HSA-199920 6.484626e-01 0.188 0 0
G2/M DNA replication checkpoint R-HSA-69478 6.484626e-01 0.188 0 0
Abacavir transmembrane transport R-HSA-2161517 6.484626e-01 0.188 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 6.484626e-01 0.188 0 0
MET Receptor Activation R-HSA-6806942 6.484626e-01 0.188 0 0
Nef and signal transduction R-HSA-164944 6.484626e-01 0.188 0 0
HDL clearance R-HSA-8964011 6.484626e-01 0.188 0 0
Leukotriene receptors R-HSA-391906 6.484626e-01 0.188 0 0
CREB3 factors activate genes R-HSA-8874211 6.484626e-01 0.188 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 6.484626e-01 0.188 0 0
Defective factor VIII causes hemophilia A R-HSA-9662001 6.484626e-01 0.188 0 0
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159763 6.484626e-01 0.188 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.542281e-01 0.184 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.542281e-01 0.184 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.542281e-01 0.184 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.542281e-01 0.184 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.542281e-01 0.184 0 0
Syndecan interactions R-HSA-3000170 6.542281e-01 0.184 0 0
Growth hormone receptor signaling R-HSA-982772 6.542281e-01 0.184 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 6.542721e-01 0.184 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.542721e-01 0.184 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 6.542721e-01 0.184 0 0
SARS-CoV-1 Infection R-HSA-9678108 6.559416e-01 0.183 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 6.564334e-01 0.183 0 0
MyD88-independent TLR4 cascade R-HSA-166166 6.586227e-01 0.181 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 6.586227e-01 0.181 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 6.595713e-01 0.181 0 0
Triglyceride metabolism R-HSA-8979227 6.595713e-01 0.181 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.598826e-01 0.181 0 0
Developmental Biology R-HSA-1266738 6.624080e-01 0.179 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.628779e-01 0.179 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.628779e-01 0.179 0 0
RNA Polymerase I Transcription R-HSA-73864 6.663108e-01 0.176 0 0
Integrin cell surface interactions R-HSA-216083 6.663108e-01 0.176 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.717275e-01 0.173 0 0
Degradation of CRY and PER proteins R-HSA-9932298 6.717275e-01 0.173 0 0
Translesion synthesis by POLI R-HSA-5656121 6.744994e-01 0.171 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 6.744994e-01 0.171 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.744994e-01 0.171 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.744994e-01 0.171 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 6.744994e-01 0.171 0 0
Post NMDA receptor activation events R-HSA-438064 6.760355e-01 0.170 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.764080e-01 0.170 0 0
HSF1-dependent transactivation R-HSA-3371571 6.803799e-01 0.167 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.803799e-01 0.167 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.803799e-01 0.167 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.819182e-01 0.166 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.819182e-01 0.166 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 6.819182e-01 0.166 0 0
Opioid Signalling R-HSA-111885 6.826237e-01 0.166 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.870260e-01 0.163 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.870260e-01 0.163 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 6.870260e-01 0.163 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.870260e-01 0.163 0 0
Recycling of eIF2:GDP R-HSA-72731 6.870260e-01 0.163 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 6.870260e-01 0.163 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.870260e-01 0.163 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.870260e-01 0.163 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.870260e-01 0.163 0 0
Cysteine formation from homocysteine R-HSA-1614603 6.870260e-01 0.163 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 6.870260e-01 0.163 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 6.870260e-01 0.163 0 0
VLDL clearance R-HSA-8964046 6.870260e-01 0.163 0 0
Ca2+ activated K+ channels R-HSA-1296052 6.870260e-01 0.163 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 6.870260e-01 0.163 0 0
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782 6.870260e-01 0.163 0 0
Formation of paraxial mesoderm R-HSA-9793380 6.887119e-01 0.162 0 0
Cellular response to chemical stress R-HSA-9711123 6.889564e-01 0.162 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.965451e-01 0.157 0 0
Hedgehog 'on' state R-HSA-5632684 6.966930e-01 0.157 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.966930e-01 0.157 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.975173e-01 0.156 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 6.975173e-01 0.156 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 6.975173e-01 0.156 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.975173e-01 0.156 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.000003e-01 0.155 0 0
Translesion synthesis by POLK R-HSA-5655862 7.000848e-01 0.155 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 7.000848e-01 0.155 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.000848e-01 0.155 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 7.000848e-01 0.155 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.001909e-01 0.155 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 7.001909e-01 0.155 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 7.001909e-01 0.155 0 0
Signaling by NOTCH2 R-HSA-1980145 7.001909e-01 0.155 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.001909e-01 0.155 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.026649e-01 0.153 0 0
Signaling by PDGF R-HSA-186797 7.026649e-01 0.153 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.044491e-01 0.152 0 0
Signaling by SCF-KIT R-HSA-1433557 7.048545e-01 0.152 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 7.119485e-01 0.148 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 7.135606e-01 0.147 0 0
Ub-specific processing proteases R-HSA-5689880 7.167199e-01 0.145 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 7.175644e-01 0.144 0 0
TRP channels R-HSA-3295583 7.175644e-01 0.144 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.176947e-01 0.144 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 7.176947e-01 0.144 0 0
Regulation of Apoptosis R-HSA-169911 7.176947e-01 0.144 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 7.176947e-01 0.144 0 0
Reverse Transcription of HIV RNA R-HSA-162589 7.213610e-01 0.142 0 0
Minus-strand DNA synthesis R-HSA-164516 7.213610e-01 0.142 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.213610e-01 0.142 0 0
ALKBH3 mediated reversal of alkylation damage R-HSA-112126 7.213610e-01 0.142 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.213610e-01 0.142 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 7.213610e-01 0.142 0 0
MET receptor recycling R-HSA-8875656 7.213610e-01 0.142 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.213610e-01 0.142 0 0
FGFR1b ligand binding and activation R-HSA-190370 7.213610e-01 0.142 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 7.213610e-01 0.142 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 7.213610e-01 0.142 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 7.213610e-01 0.142 0 0
Interleukin-9 signaling R-HSA-8985947 7.213610e-01 0.142 0 0
Interleukin-23 signaling R-HSA-9020933 7.213610e-01 0.142 0 0
Co-stimulation by ICOS R-HSA-9927354 7.213610e-01 0.142 0 0
Adrenoceptors R-HSA-390696 7.213610e-01 0.142 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.213610e-01 0.142 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 7.213610e-01 0.142 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.219668e-01 0.141 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.239761e-01 0.140 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.239761e-01 0.140 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.239761e-01 0.140 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.239761e-01 0.140 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.341791e-01 0.134 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 7.344326e-01 0.134 0 0
RNA Polymerase III Transcription R-HSA-74158 7.344326e-01 0.134 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 7.344326e-01 0.134 0 0
HSF1 activation R-HSA-3371511 7.344326e-01 0.134 0 0
FLT3 signaling in disease R-HSA-9682385 7.344326e-01 0.134 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 7.354027e-01 0.133 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.355747e-01 0.133 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 7.355747e-01 0.133 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.355747e-01 0.133 0 0
Cristae formation R-HSA-8949613 7.365643e-01 0.133 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.365643e-01 0.133 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 7.446242e-01 0.128 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 7.452340e-01 0.128 0 0
GAB1 signalosome R-HSA-180292 7.462370e-01 0.127 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 7.462370e-01 0.127 0 0
FGFR1 ligand binding and activation R-HSA-190242 7.462370e-01 0.127 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.462370e-01 0.127 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 7.462370e-01 0.127 0 0
Platelet sensitization by LDL R-HSA-432142 7.462370e-01 0.127 0 0
Tie2 Signaling R-HSA-210993 7.462370e-01 0.127 0 0
Nephron development R-HSA-9831926 7.462370e-01 0.127 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.462370e-01 0.127 0 0
Regulation of pyruvate metabolism R-HSA-9861718 7.500324e-01 0.125 0 0
Diseases of DNA repair R-HSA-9675135 7.500324e-01 0.125 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.504115e-01 0.125 0 0
Collagen chain trimerization R-HSA-8948216 7.504115e-01 0.125 0 0
HCMV Infection R-HSA-9609646 7.514796e-01 0.124 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 7.516007e-01 0.124 0 0
Interleukin-21 signaling R-HSA-9020958 7.519311e-01 0.124 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.519311e-01 0.124 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.519311e-01 0.124 0 0
Enzymatic degradation of Dopamine by monoamine oxidase R-HSA-379398 7.519311e-01 0.124 0 0
ARMS-mediated activation R-HSA-170984 7.519311e-01 0.124 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.519311e-01 0.124 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.519311e-01 0.124 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.519311e-01 0.124 0 0
Cellular response to mitochondrial stress R-HSA-9840373 7.519311e-01 0.124 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.519311e-01 0.124 0 0
Pyrimidine salvage R-HSA-73614 7.545374e-01 0.122 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 7.545374e-01 0.122 0 0
Inflammasomes R-HSA-622312 7.545374e-01 0.122 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.575635e-01 0.121 0 0
Vesicle-mediated transport R-HSA-5653656 7.582385e-01 0.120 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.612440e-01 0.118 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.638939e-01 0.117 0 0
Platelet degranulation R-HSA-114608 7.646661e-01 0.117 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 7.656415e-01 0.116 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.669378e-01 0.115 0 0
Translesion Synthesis by POLH R-HSA-110320 7.669378e-01 0.115 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.669378e-01 0.115 0 0
Diseases of hemostasis R-HSA-9671793 7.669378e-01 0.115 0 0
Signaling by Erythropoietin R-HSA-9006335 7.715088e-01 0.113 0 0
DNA methylation R-HSA-5334118 7.715088e-01 0.113 0 0
mRNA Capping R-HSA-72086 7.715088e-01 0.113 0 0
Termination of translesion DNA synthesis R-HSA-5656169 7.715088e-01 0.113 0 0
GPER1 signaling R-HSA-9634597 7.771655e-01 0.109 0 0
Regulated Necrosis R-HSA-5218859 7.775210e-01 0.109 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 7.775210e-01 0.109 0 0
Binding and entry of HIV virion R-HSA-173107 7.791488e-01 0.108 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 7.791488e-01 0.108 0 0
Folding of actin by CCT/TriC R-HSA-390450 7.791488e-01 0.108 0 0
TET1,2,3 and TDG demethylate DNA R-HSA-5221030 7.791488e-01 0.108 0 0
Enzymatic degradation of dopamine by COMT R-HSA-379397 7.791488e-01 0.108 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.791488e-01 0.108 0 0
Interleukin-27 signaling R-HSA-9020956 7.791488e-01 0.108 0 0
Regulation of CDH11 function R-HSA-9762292 7.791488e-01 0.108 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 7.791488e-01 0.108 0 0
Formation of intermediate mesoderm R-HSA-9761174 7.791488e-01 0.108 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.791488e-01 0.108 0 0
Arachidonate production from DAG R-HSA-426048 7.791488e-01 0.108 0 0
Pexophagy R-HSA-9664873 7.791488e-01 0.108 0 0
MAPK3 (ERK1) activation R-HSA-110056 7.791488e-01 0.108 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.801356e-01 0.108 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 7.820928e-01 0.107 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 7.820928e-01 0.107 0 0
Interferon Signaling R-HSA-913531 7.859819e-01 0.105 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.861526e-01 0.104 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.861526e-01 0.104 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.861526e-01 0.104 0 0
Signal transduction by L1 R-HSA-445144 7.861526e-01 0.104 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.861526e-01 0.104 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.875074e-01 0.104 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.875074e-01 0.104 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.875074e-01 0.104 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 7.875074e-01 0.104 0 0
Extension of Telomeres R-HSA-180786 7.883988e-01 0.103 0 0
Gap junction trafficking and regulation R-HSA-157858 7.898559e-01 0.102 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 7.914579e-01 0.102 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.937112e-01 0.100 0 0
SARS-CoV-2 Infection R-HSA-9694516 7.937485e-01 0.100 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.939092e-01 0.100 0 0
Generation of second messenger molecules R-HSA-202433 7.939092e-01 0.100 0 0
Attenuation phase R-HSA-3371568 7.939092e-01 0.100 0 0
Interleukin-2 family signaling R-HSA-451927 7.939092e-01 0.100 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.939092e-01 0.100 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.939092e-01 0.100 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.939092e-01 0.100 0 0
Cargo concentration in the ER R-HSA-5694530 8.025647e-01 0.096 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.025647e-01 0.096 0 0
Downstream signal transduction R-HSA-186763 8.025647e-01 0.096 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 8.033817e-01 0.095 0 0
Interleukin-2 signaling R-HSA-9020558 8.033817e-01 0.095 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.033817e-01 0.095 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.033817e-01 0.095 0 0
vRNA Synthesis R-HSA-192814 8.033817e-01 0.095 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.033817e-01 0.095 0 0
Synthesis of PI R-HSA-1483226 8.033817e-01 0.095 0 0
Bicarbonate transporters R-HSA-425381 8.033817e-01 0.095 0 0
Suppression of apoptosis R-HSA-9635465 8.033817e-01 0.095 0 0
Prostanoid ligand receptors R-HSA-391908 8.033817e-01 0.095 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 8.039584e-01 0.095 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 8.039584e-01 0.095 0 0
ERK/MAPK targets R-HSA-198753 8.039584e-01 0.095 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 8.040655e-01 0.095 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.069800e-01 0.093 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.069800e-01 0.093 0 0
Base Excision Repair R-HSA-73884 8.099787e-01 0.092 0 0
Aquaporin-mediated transport R-HSA-445717 8.105224e-01 0.091 0 0
Signaling by Interleukins R-HSA-449147 8.112090e-01 0.091 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.112922e-01 0.091 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.112922e-01 0.091 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.112922e-01 0.091 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.112922e-01 0.091 0 0
Meiotic recombination R-HSA-912446 8.135351e-01 0.090 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.167149e-01 0.088 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 8.190648e-01 0.087 0 0
Intra-Golgi traffic R-HSA-6811438 8.193672e-01 0.087 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 8.204328e-01 0.086 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 8.204328e-01 0.086 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 8.204328e-01 0.086 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.208843e-01 0.086 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 8.209831e-01 0.086 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.226388e-01 0.085 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.226388e-01 0.085 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.249569e-01 0.084 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 8.249569e-01 0.084 0 0
ERKs are inactivated R-HSA-202670 8.249569e-01 0.084 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.249569e-01 0.084 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.249569e-01 0.084 0 0
Sodium/Calcium exchangers R-HSA-425561 8.249569e-01 0.084 0 0
Anchoring fibril formation R-HSA-2214320 8.249569e-01 0.084 0 0
Gamma-carboxylation of protein precursors R-HSA-159740 8.249569e-01 0.084 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.281564e-01 0.082 0 0
Integrin signaling R-HSA-354192 8.299935e-01 0.081 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.299935e-01 0.081 0 0
G-protein beta:gamma signalling R-HSA-397795 8.299935e-01 0.081 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 8.310915e-01 0.080 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.310915e-01 0.080 0 0
Adaptive Immune System R-HSA-1280218 8.332257e-01 0.079 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.349871e-01 0.078 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.350290e-01 0.078 0 0
Smooth Muscle Contraction R-HSA-445355 8.350290e-01 0.078 0 0
Signaling by Insulin receptor R-HSA-74752 8.353931e-01 0.078 0 0
Interleukin-1 signaling R-HSA-9020702 8.355230e-01 0.078 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 8.356536e-01 0.078 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 8.356536e-01 0.078 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 8.356536e-01 0.078 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.356536e-01 0.078 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.356536e-01 0.078 0 0
Signaling by ERBB4 R-HSA-1236394 8.374402e-01 0.077 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 8.421748e-01 0.075 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.424374e-01 0.074 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.424374e-01 0.074 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.441658e-01 0.074 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 8.441658e-01 0.074 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 8.441658e-01 0.074 0 0
Regulation of IFNG signaling R-HSA-877312 8.441658e-01 0.074 0 0
p75NTR recruits signalling complexes R-HSA-209543 8.441658e-01 0.074 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 8.441658e-01 0.074 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 8.441658e-01 0.074 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 8.441658e-01 0.074 0 0
Polymerase switching R-HSA-69091 8.441658e-01 0.074 0 0
Leading Strand Synthesis R-HSA-69109 8.441658e-01 0.074 0 0
MET activates RAS signaling R-HSA-8851805 8.441658e-01 0.074 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 8.441658e-01 0.074 0 0
Interleukin-35 Signalling R-HSA-8984722 8.441658e-01 0.074 0 0
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854 8.441658e-01 0.074 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 8.496976e-01 0.071 0 0
Interleukin-20 family signaling R-HSA-8854691 8.496976e-01 0.071 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.496976e-01 0.071 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.496976e-01 0.071 0 0
Carnitine shuttle R-HSA-200425 8.496976e-01 0.071 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 8.499260e-01 0.071 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.526396e-01 0.069 0 0
Proteasome assembly R-HSA-9907900 8.526396e-01 0.069 0 0
DAP12 interactions R-HSA-2172127 8.526396e-01 0.069 0 0
Netrin-1 signaling R-HSA-373752 8.526396e-01 0.069 0 0
Gap junction trafficking R-HSA-190828 8.526396e-01 0.069 0 0
Neddylation R-HSA-8951664 8.530506e-01 0.069 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.540839e-01 0.068 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.540839e-01 0.068 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.540839e-01 0.068 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.540839e-01 0.068 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.540839e-01 0.068 0 0
G alpha (z) signalling events R-HSA-418597 8.544521e-01 0.068 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 8.544521e-01 0.068 0 0
Chromosome Maintenance R-HSA-73886 8.572517e-01 0.067 0 0
ER to Golgi Anterograde Transport R-HSA-199977 8.596507e-01 0.066 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.603351e-01 0.065 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.612677e-01 0.065 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.612677e-01 0.065 0 0
Interleukin-6 signaling R-HSA-1059683 8.612677e-01 0.065 0 0
FGFR1c ligand binding and activation R-HSA-190373 8.612677e-01 0.065 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 8.612677e-01 0.065 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 8.612677e-01 0.065 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 8.612677e-01 0.065 0 0
Maturation of nucleoprotein R-HSA-9683610 8.612677e-01 0.065 0 0
SLC transporter disorders R-HSA-5619102 8.621853e-01 0.064 0 0
Somitogenesis R-HSA-9824272 8.625093e-01 0.064 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 8.625093e-01 0.064 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 8.625093e-01 0.064 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 8.626396e-01 0.064 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.626396e-01 0.064 0 0
Complex III assembly R-HSA-9865881 8.626396e-01 0.064 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.626396e-01 0.064 0 0
Signaling by FGFR1 R-HSA-5654736 8.634261e-01 0.064 0 0
Signalling to ERKs R-HSA-187687 8.649709e-01 0.063 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.649709e-01 0.063 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.660960e-01 0.062 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.662855e-01 0.062 0 0
Chaperonin-mediated protein folding R-HSA-390466 8.668831e-01 0.062 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.697100e-01 0.061 0 0
Regulation of TNFR1 signaling R-HSA-5357905 8.718075e-01 0.060 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.718075e-01 0.060 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.718075e-01 0.060 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.745523e-01 0.058 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 8.745523e-01 0.058 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.745523e-01 0.058 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.745523e-01 0.058 0 0
Tight junction interactions R-HSA-420029 8.745523e-01 0.058 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.745523e-01 0.058 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.751359e-01 0.058 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.751359e-01 0.058 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.751359e-01 0.058 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.751359e-01 0.058 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.764937e-01 0.057 0 0
NRIF signals cell death from the nucleus R-HSA-205043 8.764937e-01 0.057 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 8.764937e-01 0.057 0 0
cGMP effects R-HSA-418457 8.764937e-01 0.057 0 0
Physiological factors R-HSA-5578768 8.764937e-01 0.057 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.764937e-01 0.057 0 0
Telomere Maintenance R-HSA-157579 8.781954e-01 0.056 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.805580e-01 0.055 0 0
Synthesis of PC R-HSA-1483191 8.805580e-01 0.055 0 0
Signaling by FGFR2 R-HSA-5654738 8.837523e-01 0.054 0 0
Cilium Assembly R-HSA-5617833 8.840555e-01 0.054 0 0
Signaling by FGFR R-HSA-190236 8.843592e-01 0.053 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.846162e-01 0.053 0 0
Degradation of AXIN R-HSA-4641257 8.846162e-01 0.053 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 8.846162e-01 0.053 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 8.855056e-01 0.053 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.855056e-01 0.053 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.855056e-01 0.053 0 0
Interleukin-1 family signaling R-HSA-446652 8.860057e-01 0.053 0 0
Downstream TCR signaling R-HSA-202424 8.868256e-01 0.052 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 8.883941e-01 0.051 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.900494e-01 0.051 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.900494e-01 0.051 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.900494e-01 0.051 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.900494e-01 0.051 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.900494e-01 0.051 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.900494e-01 0.051 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.900494e-01 0.051 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.900494e-01 0.051 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.934486e-01 0.049 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.934486e-01 0.049 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.955667e-01 0.048 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 8.955667e-01 0.048 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.955667e-01 0.048 0 0
Signaling by FGFR3 in disease R-HSA-5655332 8.955667e-01 0.048 0 0
Triglyceride biosynthesis R-HSA-75109 8.955667e-01 0.048 0 0
Synthesis of PE R-HSA-1483213 8.955667e-01 0.048 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 8.955667e-01 0.048 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.982722e-01 0.047 0 0
MAP kinase activation R-HSA-450294 9.015871e-01 0.045 0 0
Collagen degradation R-HSA-1442490 9.015871e-01 0.045 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.016690e-01 0.045 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.021180e-01 0.045 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 9.021180e-01 0.045 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 9.021180e-01 0.045 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 9.021180e-01 0.045 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 9.021180e-01 0.045 0 0
Activation of the phototransduction cascade R-HSA-2485179 9.021180e-01 0.045 0 0
Serotonin and melatonin biosynthesis R-HSA-209931 9.021180e-01 0.045 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 9.021180e-01 0.045 0 0
Attachment and Entry R-HSA-9678110 9.021180e-01 0.045 0 0
Atorvastatin ADME R-HSA-9754706 9.021180e-01 0.045 0 0
Differentiation of T cells R-HSA-9945266 9.021180e-01 0.045 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 9.021180e-01 0.045 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.025494e-01 0.045 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.025494e-01 0.045 0 0
Regulation of RAS by GAPs R-HSA-5658442 9.037618e-01 0.044 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.037618e-01 0.044 0 0
Protein folding R-HSA-391251 9.042181e-01 0.044 0 0
Telomere Extension By Telomerase R-HSA-171319 9.047994e-01 0.043 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 9.047994e-01 0.043 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 9.047994e-01 0.043 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 9.079963e-01 0.042 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.090707e-01 0.041 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.090707e-01 0.041 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 9.128625e-01 0.040 0 0
Heme assimilation R-HSA-9927020 9.128625e-01 0.040 0 0
Fibronectin matrix formation R-HSA-1566977 9.128625e-01 0.040 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.128625e-01 0.040 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 9.128625e-01 0.040 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.128625e-01 0.040 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.132643e-01 0.039 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.132643e-01 0.039 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 9.132643e-01 0.039 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 9.132643e-01 0.039 0 0
Platelet calcium homeostasis R-HSA-418360 9.132643e-01 0.039 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 9.132643e-01 0.039 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 9.132643e-01 0.039 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.132643e-01 0.039 0 0
Glucagon-type ligand receptors R-HSA-420092 9.132643e-01 0.039 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 9.140373e-01 0.039 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.145103e-01 0.039 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.161500e-01 0.038 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.161808e-01 0.038 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.161808e-01 0.038 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.164124e-01 0.038 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.164124e-01 0.038 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.169250e-01 0.038 0 0
Neutrophil degranulation R-HSA-6798695 9.169291e-01 0.038 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.184846e-01 0.037 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.192914e-01 0.037 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.203516e-01 0.036 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.210186e-01 0.036 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.210186e-01 0.036 0 0
Activation of BH3-only proteins R-HSA-114452 9.210186e-01 0.036 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.210186e-01 0.036 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.224281e-01 0.035 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 9.224281e-01 0.035 0 0
Glycogen storage diseases R-HSA-3229121 9.224281e-01 0.035 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.224281e-01 0.035 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 9.224281e-01 0.035 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 9.224281e-01 0.035 0 0
Catecholamine biosynthesis R-HSA-209905 9.224281e-01 0.035 0 0
Uptake and function of anthrax toxins R-HSA-5210891 9.224281e-01 0.035 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.227039e-01 0.035 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.230020e-01 0.035 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.230020e-01 0.035 0 0
Toll-like Receptor Cascades R-HSA-168898 9.254816e-01 0.034 0 0
Pyruvate metabolism R-HSA-70268 9.278650e-01 0.033 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.281163e-01 0.032 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.284539e-01 0.032 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.291127e-01 0.032 0 0
Depyrimidination R-HSA-73928 9.291127e-01 0.032 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.346081e-01 0.029 0 0
Signaling by FGFR4 R-HSA-5654743 9.347744e-01 0.029 0 0
Defective pyroptosis R-HSA-9710421 9.347744e-01 0.029 0 0
Regulation of insulin secretion R-HSA-422356 9.361812e-01 0.029 0 0
ER-Phagosome pathway R-HSA-1236974 9.362922e-01 0.029 0 0
Stimuli-sensing channels R-HSA-2672351 9.366401e-01 0.028 0 0
TNF signaling R-HSA-75893 9.385186e-01 0.028 0 0
Crosslinking of collagen fibrils R-HSA-2243919 9.385258e-01 0.028 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 9.385258e-01 0.028 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.385258e-01 0.028 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 9.385258e-01 0.028 0 0
E2F mediated regulation of DNA replication R-HSA-113510 9.385258e-01 0.028 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 9.385258e-01 0.028 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 9.385258e-01 0.028 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.385258e-01 0.028 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 9.385258e-01 0.028 0 0
Maturation of nucleoprotein R-HSA-9694631 9.385258e-01 0.028 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 9.405414e-01 0.027 0 0
Recycling of bile acids and salts R-HSA-159418 9.405414e-01 0.027 0 0
ABC-family proteins mediated transport R-HSA-382556 9.434018e-01 0.025 0 0
Nucleosome assembly R-HSA-774815 9.448653e-01 0.025 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.448653e-01 0.025 0 0
Signaling by FGFR3 R-HSA-5654741 9.448653e-01 0.025 0 0
Glycogen synthesis R-HSA-3322077 9.452754e-01 0.024 0 0
Signaling by NODAL R-HSA-1181150 9.452754e-01 0.024 0 0
Creatine metabolism R-HSA-71288 9.452754e-01 0.024 0 0
Pregnenolone biosynthesis R-HSA-196108 9.452754e-01 0.024 0 0
Protein hydroxylation R-HSA-9629569 9.452754e-01 0.024 0 0
Cellular response to starvation R-HSA-9711097 9.458253e-01 0.024 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.473600e-01 0.023 0 0
Interleukin-17 signaling R-HSA-448424 9.473600e-01 0.023 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.477916e-01 0.023 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.493479e-01 0.023 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.493479e-01 0.023 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.505810e-01 0.022 0 0
eNOS activation R-HSA-203615 9.509070e-01 0.022 0 0
Mitophagy R-HSA-5205647 9.509070e-01 0.022 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 9.509070e-01 0.022 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.509070e-01 0.022 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.510209e-01 0.022 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.512843e-01 0.022 0 0
G-protein activation R-HSA-202040 9.512843e-01 0.022 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 9.512843e-01 0.022 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 9.512843e-01 0.022 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 9.512843e-01 0.022 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.512843e-01 0.022 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 9.512843e-01 0.022 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 9.512843e-01 0.022 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 9.512843e-01 0.022 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.512843e-01 0.022 0 0
Basigin interactions R-HSA-210991 9.512843e-01 0.022 0 0
Parasite infection R-HSA-9664407 9.513400e-01 0.022 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.513400e-01 0.022 0 0
Leishmania phagocytosis R-HSA-9664417 9.513400e-01 0.022 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.548800e-01 0.020 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.554191e-01 0.020 0 0
Developmental Cell Lineages R-HSA-9734767 9.559704e-01 0.020 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.562406e-01 0.019 0 0
Collagen formation R-HSA-1474290 9.565894e-01 0.019 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.566337e-01 0.019 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.566337e-01 0.019 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.566337e-01 0.019 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 9.566337e-01 0.019 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.566337e-01 0.019 0 0
Glutathione synthesis and recycling R-HSA-174403 9.566337e-01 0.019 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.566337e-01 0.019 0 0
Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 9.566337e-01 0.019 0 0
Attachment and Entry R-HSA-9694614 9.566337e-01 0.019 0 0
Assembly Of The HIV Virion R-HSA-175474 9.566337e-01 0.019 0 0
Metal ion SLC transporters R-HSA-425410 9.573116e-01 0.019 0 0
Formation of the cornified envelope R-HSA-6809371 9.578779e-01 0.019 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 9.582895e-01 0.019 0 0
Phospholipid metabolism R-HSA-1483257 9.591566e-01 0.018 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.595326e-01 0.018 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.603946e-01 0.018 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.607893e-01 0.017 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.608382e-01 0.017 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.613960e-01 0.017 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 9.613960e-01 0.017 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.613960e-01 0.017 0 0
Cellular hexose transport R-HSA-189200 9.613960e-01 0.017 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.619318e-01 0.017 0 0
Cleavage of the damaged purine R-HSA-110331 9.632806e-01 0.016 0 0
NCAM1 interactions R-HSA-419037 9.632806e-01 0.016 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.632806e-01 0.016 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.632945e-01 0.016 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.656355e-01 0.015 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.656355e-01 0.015 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.656355e-01 0.015 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 9.656355e-01 0.015 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 9.656355e-01 0.015 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.656355e-01 0.015 0 0
Formation of the ureteric bud R-HSA-9830674 9.656355e-01 0.015 0 0
Integration of energy metabolism R-HSA-163685 9.665761e-01 0.015 0 0
Depurination R-HSA-73927 9.666937e-01 0.015 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 9.666937e-01 0.015 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.670031e-01 0.015 0 0
The phototransduction cascade R-HSA-2514856 9.670854e-01 0.015 0 0
Extracellular matrix organization R-HSA-1474244 9.676904e-01 0.014 0 0
Leishmania infection R-HSA-9658195 9.682942e-01 0.014 0 0
Parasitic Infection Pathways R-HSA-9824443 9.682942e-01 0.014 0 0
Thromboxane signalling through TP receptor R-HSA-428930 9.694097e-01 0.013 0 0
Interleukin-6 family signaling R-HSA-6783589 9.694097e-01 0.013 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.694097e-01 0.013 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.694097e-01 0.013 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 9.694097e-01 0.013 0 0
Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 9.694097e-01 0.013 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.694097e-01 0.013 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.698003e-01 0.013 0 0
ABC transporter disorders R-HSA-5619084 9.708041e-01 0.013 0 0
Glycogen metabolism R-HSA-8982491 9.726265e-01 0.012 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 9.727696e-01 0.012 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 9.727696e-01 0.012 0 0
G protein gated Potassium channels R-HSA-1296059 9.727696e-01 0.012 0 0
Long-term potentiation R-HSA-9620244 9.727696e-01 0.012 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 9.727696e-01 0.012 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.727696e-01 0.012 0 0
Hyaluronan degradation R-HSA-2160916 9.727696e-01 0.012 0 0
Laminin interactions R-HSA-3000157 9.727696e-01 0.012 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.727696e-01 0.012 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.749876e-01 0.011 0 0
Maturation of spike protein R-HSA-9694548 9.751965e-01 0.011 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 9.757606e-01 0.011 0 0
MET activates PTK2 signaling R-HSA-8874081 9.757606e-01 0.011 0 0
Signaling by EGFR in Cancer R-HSA-1643713 9.757606e-01 0.011 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.757606e-01 0.011 0 0
Sphingolipid catabolism R-HSA-9845614 9.757606e-01 0.011 0 0
Abacavir ADME R-HSA-2161522 9.757606e-01 0.011 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 9.757606e-01 0.011 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.762335e-01 0.010 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.762631e-01 0.010 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.775323e-01 0.010 0 0
Packaging Of Telomere Ends R-HSA-171306 9.784232e-01 0.009 0 0
Cobalamin (Cbl) metabolism R-HSA-9759218 9.784232e-01 0.009 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 9.784232e-01 0.009 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.784232e-01 0.009 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 9.784232e-01 0.009 0 0
Signaling by BMP R-HSA-201451 9.784232e-01 0.009 0 0
Ion homeostasis R-HSA-5578775 9.788375e-01 0.009 0 0
Activation of GABAB receptors R-HSA-991365 9.796544e-01 0.009 0 0
GABA B receptor activation R-HSA-977444 9.796544e-01 0.009 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.796544e-01 0.009 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.796544e-01 0.009 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.800774e-01 0.009 0 0
Dectin-2 family R-HSA-5621480 9.806491e-01 0.008 0 0
RSV-host interactions R-HSA-9833110 9.807213e-01 0.008 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 9.807935e-01 0.008 0 0
Prednisone ADME R-HSA-9757110 9.807935e-01 0.008 0 0
Insulin receptor recycling R-HSA-77387 9.807935e-01 0.008 0 0
Mitochondrial protein degradation R-HSA-9837999 9.808990e-01 0.008 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 9.810973e-01 0.008 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.823120e-01 0.008 0 0
Activation of Matrix Metalloproteinases R-HSA-1592389 9.829035e-01 0.007 0 0
Platelet homeostasis R-HSA-418346 9.832486e-01 0.007 0 0
Surfactant metabolism R-HSA-5683826 9.833311e-01 0.007 0 0
Peptide hormone metabolism R-HSA-2980736 9.843905e-01 0.007 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.847819e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.847819e-01 0.007 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.849186e-01 0.007 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.849359e-01 0.007 0 0
Ribosome-associated quality control R-HSA-9948299 9.849760e-01 0.007 0 0
Metabolism of polyamines R-HSA-351202 9.852368e-01 0.006 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.854648e-01 0.006 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.864539e-01 0.006 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.864539e-01 0.006 0 0
Nucleotide salvage R-HSA-8956321 9.865194e-01 0.006 0 0
Peptide chain elongation R-HSA-156902 9.875613e-01 0.005 0 0
Mitochondrial protein import R-HSA-1268020 9.876946e-01 0.005 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.879230e-01 0.005 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.879424e-01 0.005 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 9.892673e-01 0.005 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 9.892673e-01 0.005 0 0
Neurotransmitter release cycle R-HSA-112310 9.893983e-01 0.005 0 0
Cholesterol biosynthesis R-HSA-191273 9.897069e-01 0.004 0 0
Ion transport by P-type ATPases R-HSA-936837 9.897562e-01 0.004 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.897562e-01 0.004 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.904332e-01 0.004 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.904468e-01 0.004 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.904468e-01 0.004 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.905511e-01 0.004 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.909760e-01 0.004 0 0
PKR-mediated signaling R-HSA-9833482 9.913288e-01 0.004 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.913605e-01 0.004 0 0
Viral Infection Pathways R-HSA-9824446 9.913931e-01 0.004 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 9.914967e-01 0.004 0 0
Signal amplification R-HSA-392518 9.914967e-01 0.004 0 0
Hyaluronan metabolism R-HSA-2142845 9.914967e-01 0.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.914967e-01 0.004 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.914967e-01 0.004 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.917718e-01 0.004 0 0
Kidney development R-HSA-9830369 9.922372e-01 0.003 0 0
Interferon gamma signaling R-HSA-877300 9.922548e-01 0.003 0 0
Transmission across Chemical Synapses R-HSA-112315 9.924092e-01 0.003 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.924312e-01 0.003 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.924312e-01 0.003 0 0
Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 9.924312e-01 0.003 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.925683e-01 0.003 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.934866e-01 0.003 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.940010e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.940036e-01 0.003 0 0
Hemostasis R-HSA-109582 9.942659e-01 0.002 0 0
Paracetamol ADME R-HSA-9753281 9.945315e-01 0.002 0 0
Elastic fibre formation R-HSA-1566948 9.946628e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.946628e-01 0.002 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.946628e-01 0.002 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.950650e-01 0.002 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.952495e-01 0.002 0 0
Muscle contraction R-HSA-397014 9.954862e-01 0.002 0 0
Synthesis of PA R-HSA-1483166 9.955473e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.957718e-01 0.002 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.962366e-01 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.962366e-01 0.002 0 0
FLT3 Signaling R-HSA-9607240 9.962366e-01 0.002 0 0
Peroxisomal protein import R-HSA-9033241 9.963773e-01 0.002 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.963773e-01 0.002 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.966504e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9683701 9.966504e-01 0.001 0 0
GABA receptor activation R-HSA-977443 9.967332e-01 0.001 0 0
RAB geranylgeranylation R-HSA-8873719 9.967332e-01 0.001 0 0
tRNA Aminoacylation R-HSA-379724 9.967332e-01 0.001 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.967332e-01 0.001 0 0
Translation of Structural Proteins R-HSA-9694635 9.969738e-01 0.001 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.969763e-01 0.001 0 0
Endogenous sterols R-HSA-211976 9.970547e-01 0.001 0 0
Interleukin-10 signaling R-HSA-6783783 9.972495e-01 0.001 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.973466e-01 0.001 0 0
Pyrimidine catabolism R-HSA-73621 9.973466e-01 0.001 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.973466e-01 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.974727e-01 0.001 0 0
Signaling by PTK6 R-HSA-8848021 9.976071e-01 0.001 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.976071e-01 0.001 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.976384e-01 0.001 0 0
Amine ligand-binding receptors R-HSA-375280 9.976384e-01 0.001 0 0
Methylation R-HSA-156581 9.976384e-01 0.001 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.976903e-01 0.001 0 0
Ion channel transport R-HSA-983712 9.978000e-01 0.001 0 0
Protein localization R-HSA-9609507 9.978072e-01 0.001 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.978981e-01 0.001 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.979924e-01 0.001 0 0
Eukaryotic Translation Termination R-HSA-72764 9.982395e-01 0.001 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.982498e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.983350e-01 0.001 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.984236e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.984236e-01 0.001 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.984236e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.984500e-01 0.001 0 0
Intraflagellar transport R-HSA-5620924 9.985182e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.985182e-01 0.001 0 0
Gluconeogenesis R-HSA-70263 9.985182e-01 0.001 0 0
G alpha (s) signalling events R-HSA-418555 9.986214e-01 0.001 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.986812e-01 0.001 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.986970e-01 0.001 0 0
rRNA processing R-HSA-72312 9.987060e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.987780e-01 0.001 0 0
Azathioprine ADME R-HSA-9748787 9.988262e-01 0.001 0 0
COPII-mediated vesicle transport R-HSA-204005 9.988491e-01 0.001 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.988491e-01 0.001 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.989131e-01 0.000 0 0
ECM proteoglycans R-HSA-3000178 9.989640e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.989640e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.989777e-01 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 9.989833e-01 0.000 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.989833e-01 0.000 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.990675e-01 0.000 0 0
Viral mRNA Translation R-HSA-192823 9.991548e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.991591e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.991591e-01 0.000 0 0
Nucleotide biosynthesis R-HSA-8956320 9.991726e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.992207e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.993206e-01 0.000 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.994168e-01 0.000 0 0
Neuronal System R-HSA-112316 9.996238e-01 0.000 0 0
Glutathione conjugation R-HSA-156590 9.996342e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.996406e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.996468e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.996620e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996648e-01 0.000 0 0
Complex I biogenesis R-HSA-6799198 9.997422e-01 0.000 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.997706e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.997706e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.998106e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.998383e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.998508e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.998561e-01 0.000 0 0
Immune System R-HSA-168256 9.998837e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998986e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.998986e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999098e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999111e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.999197e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.999197e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.999199e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999286e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999295e-01 0.000 0 0
Post-translational protein modification R-HSA-597592 9.999325e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999360e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999480e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999480e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.999559e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.999559e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999581e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.999637e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999721e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999757e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999778e-01 0.000 0 0
Translation R-HSA-72766 9.999823e-01 0.000 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.999843e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999886e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.999951e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999951e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.999953e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999957e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999991e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999991e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999993e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999993e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999994e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999996e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999997e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999998e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999999e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999999e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999999e-01 0.000 0 0
Disease R-HSA-1643685 9.999999e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999999e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999999e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Sensory perception of taste R-HSA-9717189 1.000000e+00 0.000 0 0
O-linked glycosylation R-HSA-5173105 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Complement cascade R-HSA-166658 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Diseases of glycosylation R-HSA-3781865 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Signaling by ALK fusions and activated point mutants R-HSA-9725370 2.530223e-08 7.597 0 0
Signaling by ALK in cancer R-HSA-9700206 2.530223e-08 7.597 0 0
Cell Cycle R-HSA-1640170 2.087450e-07 6.680 1 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.753862e-07 6.426 0 0
mRNA Splicing - Major Pathway R-HSA-72163 5.496716e-07 6.260 0 0
mRNA Splicing R-HSA-72172 8.553773e-07 6.068 0 0
Chromatin organization R-HSA-4839726 1.912952e-06 5.718 0 0
Cell Cycle Checkpoints R-HSA-69620 4.632001e-06 5.334 1 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.132339e-06 5.290 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.726734e-06 5.059 0 0
Cellular Senescence R-HSA-2559583 7.796653e-06 5.108 0 0
Cell Cycle, Mitotic R-HSA-69278 8.652786e-06 5.063 1 0
Meiotic synapsis R-HSA-1221632 1.584883e-05 4.800 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 1.519212e-05 4.818 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.601361e-05 4.796 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 2.988469e-05 4.525 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 3.266031e-05 4.486 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 3.266031e-05 4.486 0 0
Chromatin modifying enzymes R-HSA-3247509 3.990606e-05 4.399 0 0
Mitotic Prophase R-HSA-68875 4.877160e-05 4.312 0 0
Metabolism of RNA R-HSA-8953854 5.091485e-05 4.293 0 0
G2/M Checkpoints R-HSA-69481 5.364112e-05 4.271 1 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.299507e-05 4.201 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.948259e-05 4.158 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.980686e-05 4.156 0 0
DNA Double Strand Break Response R-HSA-5693606 7.062992e-05 4.151 0 0
M Phase R-HSA-68886 7.214123e-05 4.142 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.669176e-05 4.115 0 0
Processing of DNA double-strand break ends R-HSA-5693607 8.117931e-05 4.091 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.113626e-04 3.953 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.211643e-04 3.917 0 0
Regulation of endogenous retroelements R-HSA-9842860 1.283227e-04 3.892 0 0
Meiosis R-HSA-1500620 1.468948e-04 3.833 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 2.193218e-04 3.659 0 0
Homology Directed Repair R-HSA-5693538 2.203331e-04 3.657 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 2.651899e-04 3.576 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.702329e-04 3.568 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.280453e-04 3.484 0 0
RNA Polymerase I Transcription R-HSA-73864 3.854575e-04 3.414 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.196880e-04 3.377 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.196880e-04 3.377 0 0
DNA Repair R-HSA-73894 4.605013e-04 3.337 0 0
Apoptotic execution phase R-HSA-75153 4.807278e-04 3.318 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.275322e-04 3.278 0 0
DNA Double-Strand Break Repair R-HSA-5693532 5.138918e-04 3.289 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 5.379079e-04 3.269 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 5.587220e-04 3.253 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 5.969579e-04 3.224 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.627568e-04 3.118 0 0
DNA Replication Pre-Initiation R-HSA-69002 7.875117e-04 3.104 1 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 8.570863e-04 3.067 0 0
Estrogen-dependent gene expression R-HSA-9018519 8.737259e-04 3.059 0 0
Packaging Of Telomere Ends R-HSA-171306 9.515407e-04 3.022 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.148079e-03 2.940 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.120591e-03 2.951 1 1
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.281061e-03 2.892 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.296495e-03 2.887 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.432959e-03 2.844 0 0
DNA methylation R-HSA-5334118 1.464788e-03 2.834 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.592808e-03 2.798 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.716319e-03 2.765 0 0
Activation of the pre-replicative complex R-HSA-68962 1.795035e-03 2.746 1 1
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 1.794487e-03 2.746 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 2.010249e-03 2.697 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 2.217850e-03 2.654 0 0
Depyrimidination R-HSA-73928 2.217850e-03 2.654 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 2.566844e-03 2.591 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 2.635682e-03 2.579 0 0
Nuclear Envelope Breakdown R-HSA-2980766 2.662344e-03 2.575 0 0
Mitotic Anaphase R-HSA-68882 3.149694e-03 2.502 0 0
Nucleosome assembly R-HSA-774815 3.518408e-03 2.454 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.518408e-03 2.454 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 3.360369e-03 2.474 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.353941e-03 2.474 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.398885e-03 2.469 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 3.529625e-03 2.452 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.784621e-03 2.422 0 0
DNA Replication R-HSA-69306 3.973104e-03 2.401 1 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.989071e-03 2.399 0 0
Protein ubiquitination R-HSA-8852135 4.031337e-03 2.395 0 0
Base Excision Repair R-HSA-73884 4.336059e-03 2.363 0 0
ALK mutants bind TKIs R-HSA-9700645 4.859405e-03 2.313 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.689991e-03 2.329 0 0
Unwinding of DNA R-HSA-176974 4.859405e-03 2.313 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 4.648703e-03 2.333 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 5.673533e-03 2.246 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.859745e-03 2.232 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 5.989003e-03 2.223 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.143041e-03 2.212 0 0
Assembly of the pre-replicative complex R-HSA-68867 6.399323e-03 2.194 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 6.746890e-03 2.171 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.875353e-03 2.163 0 0
Cleavage of the damaged purine R-HSA-110331 7.152597e-03 2.146 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.425586e-03 2.129 0 0
Sema4D in semaphorin signaling R-HSA-400685 7.563759e-03 2.121 0 0
Meiotic recombination R-HSA-912446 7.934718e-03 2.100 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.644618e-03 2.117 0 0
Reproduction R-HSA-1474165 7.602315e-03 2.119 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 7.990678e-03 2.097 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.006408e-03 2.097 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 8.116182e-03 2.091 0 0
Depurination R-HSA-73927 8.285865e-03 2.082 0 0
mRNA 3'-end processing R-HSA-72187 8.973051e-03 2.047 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.061705e-02 1.974 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.063709e-02 1.973 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 9.880446e-03 2.005 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 1.071406e-02 1.970 0 0
Translation initiation complex formation R-HSA-72649 1.136462e-02 1.944 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.136462e-02 1.944 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.195384e-02 1.922 0 0
HDACs deacetylate histones R-HSA-3214815 1.273075e-02 1.895 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.212700e-02 1.916 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.290009e-02 1.889 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.308402e-02 1.883 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.308402e-02 1.883 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.308402e-02 1.883 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.347954e-02 1.870 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.416375e-02 1.849 0 0
NRAGE signals death through JNK R-HSA-193648 1.421910e-02 1.847 0 0
Gene expression (Transcription) R-HSA-74160 1.426081e-02 1.846 1 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.475161e-02 1.831 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.536765e-02 1.813 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.527821e-02 1.816 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.527821e-02 1.816 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 1.621760e-02 1.790 0 0
Deubiquitination R-HSA-5688426 1.700841e-02 1.769 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 1.722532e-02 1.764 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 1.722532e-02 1.764 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 1.758847e-02 1.755 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 1.917559e-02 1.717 0 0
Chromosome Maintenance R-HSA-73886 2.170583e-02 1.663 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 2.088388e-02 1.680 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.088712e-02 1.680 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.293997e-02 1.639 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 2.364563e-02 1.626 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.401809e-02 1.619 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.460782e-02 1.609 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.460782e-02 1.609 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.479277e-02 1.606 0 0
G alpha (12/13) signalling events R-HSA-416482 2.527460e-02 1.597 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.527460e-02 1.597 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.548509e-02 1.594 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 2.548509e-02 1.594 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.591659e-02 1.586 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.591659e-02 1.586 1 1
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.591659e-02 1.586 0 0
Breakdown of the nuclear lamina R-HSA-352238 3.006254e-02 1.522 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 3.095157e-02 1.509 0 0
Cellular responses to stress R-HSA-2262752 3.112104e-02 1.507 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 3.165889e-02 1.500 0 0
MITF-M-dependent gene expression R-HSA-9856651 3.204945e-02 1.494 0 0
Cellular responses to stimuli R-HSA-8953897 3.313157e-02 1.480 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 3.486907e-02 1.458 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 3.587715e-02 1.445 0 0
Telomere Maintenance R-HSA-157579 3.694778e-02 1.432 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 4.199342e-02 1.377 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.005967e-02 1.397 0 0
Separation of Sister Chromatids R-HSA-2467813 4.152118e-02 1.382 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 4.054424e-02 1.392 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.985030e-02 1.400 0 0
mTORC1-mediated signalling R-HSA-166208 4.190269e-02 1.378 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.841056e-02 1.416 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.819975e-02 1.418 0 0
ESR-mediated signaling R-HSA-8939211 4.131153e-02 1.384 0 0
HATs acetylate histones R-HSA-3214847 4.230320e-02 1.374 0 0
Defective pyroptosis R-HSA-9710421 4.256293e-02 1.371 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.306118e-02 1.366 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.306118e-02 1.366 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 5.043887e-02 1.297 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 5.043887e-02 1.297 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 5.043887e-02 1.297 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 5.043887e-02 1.297 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 5.043887e-02 1.297 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 5.043887e-02 1.297 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 5.043887e-02 1.297 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 5.043887e-02 1.297 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 5.043887e-02 1.297 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 5.043887e-02 1.297 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 5.043887e-02 1.297 0 0
Autointegration results in viral DNA circles R-HSA-177539 4.790789e-02 1.320 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 4.533305e-02 1.344 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.679313e-02 1.330 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.642197e-02 1.333 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 5.075249e-02 1.295 0 0
Nuclear Receptor transcription pathway R-HSA-383280 4.913329e-02 1.309 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.533305e-02 1.344 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 5.043887e-02 1.297 0 0
Smooth Muscle Contraction R-HSA-445355 5.075249e-02 1.295 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 4.790789e-02 1.320 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 5.488872e-02 1.261 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 5.671539e-02 1.246 0 0
Repression of WNT target genes R-HSA-4641265 5.693584e-02 1.245 0 0
DNA strand elongation R-HSA-69190 5.716285e-02 1.243 0 0
Chaperone Mediated Autophagy R-HSA-9613829 5.751513e-02 1.240 0 0
Signaling by PTK6 R-HSA-8848021 5.790011e-02 1.237 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.790011e-02 1.237 0 0
Semaphorin interactions R-HSA-373755 5.790011e-02 1.237 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.793409e-02 1.237 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.793409e-02 1.237 0 0
PTK6 Expression R-HSA-8849473 6.165332e-02 1.210 0 0
SOS-mediated signalling R-HSA-112412 6.165332e-02 1.210 0 0
Recycling of eIF2:GDP R-HSA-72731 6.165332e-02 1.210 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 6.346464e-02 1.197 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 6.346464e-02 1.197 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 6.373054e-02 1.196 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 7.441270e-02 1.128 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 7.441270e-02 1.128 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 6.635408e-02 1.178 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 7.590575e-02 1.120 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 7.590575e-02 1.120 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 7.590575e-02 1.120 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 7.590575e-02 1.120 0 0
Striated Muscle Contraction R-HSA-390522 7.073764e-02 1.150 0 0
Nucleotide Excision Repair R-HSA-5696398 6.537914e-02 1.185 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.005354e-02 1.155 0 0
Mitotic Prometaphase R-HSA-68877 6.953190e-02 1.158 0 0
rRNA processing R-HSA-72312 7.325592e-02 1.135 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 6.974733e-02 1.156 0 0
Cell junction organization R-HSA-446728 6.593185e-02 1.181 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.701207e-02 1.113 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.845510e-02 1.105 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 7.865478e-02 1.104 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.972898e-02 1.098 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 8.180000e-02 1.087 0 0
MTOR signalling R-HSA-165159 8.341397e-02 1.079 0 0
Regulation of TP53 Activity R-HSA-5633007 8.367565e-02 1.077 0 0
Early Phase of HIV Life Cycle R-HSA-162594 8.615898e-02 1.065 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 8.739766e-02 1.059 0 0
Adherens junctions interactions R-HSA-418990 9.010599e-02 1.045 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 9.258196e-02 1.033 0 0
Cell-extracellular matrix interactions R-HSA-446353 9.258196e-02 1.033 0 0
WNT mediated activation of DVL R-HSA-201688 9.386377e-02 1.028 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 9.386377e-02 1.028 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 9.386377e-02 1.028 0 0
RUNX2 regulates bone development R-HSA-8941326 9.439219e-02 1.025 0 0
RNA Polymerase II Transcription R-HSA-73857 9.599532e-02 1.018 1 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 9.687369e-02 1.014 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 9.687369e-02 1.014 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 9.709773e-02 1.013 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 9.854544e-02 1.006 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.012215e-01 0.995 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.120750e-01 0.950 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.120750e-01 0.950 0 0
Phosphorylation of the APC/C R-HSA-176412 1.063498e-01 0.973 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.151191e-01 0.939 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.151191e-01 0.939 0 0
Cellular response to heat stress R-HSA-3371556 1.034149e-01 0.985 0 0
Signal attenuation R-HSA-74749 1.120750e-01 0.950 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.014252e-01 0.994 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.012215e-01 0.995 0 0
MTF1 activates gene expression R-HSA-5660489 1.012215e-01 0.995 0 0
Cell-Cell communication R-HSA-1500931 1.174209e-01 0.930 0 0
Nervous system development R-HSA-9675108 1.163106e-01 0.934 0 0
2-LTR circle formation R-HSA-164843 1.120750e-01 0.950 0 0
Programmed Cell Death R-HSA-5357801 1.147830e-01 0.940 0 0
Gene Silencing by RNA R-HSA-211000 1.193880e-01 0.923 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 1.209456e-01 0.917 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 1.209817e-01 0.917 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.209817e-01 0.917 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.219096e-01 0.914 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.222253e-01 0.913 0 0
Macroautophagy R-HSA-1632852 1.224211e-01 0.912 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.224401e-01 0.912 0 0
Cellular response to hypoxia R-HSA-1234174 1.237570e-01 0.907 0 0
IRS activation R-HSA-74713 1.302067e-01 0.885 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.302067e-01 0.885 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.302067e-01 0.885 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.302067e-01 0.885 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.302067e-01 0.885 0 0
CASP5 inflammasome assembly R-HSA-9948011 1.635691e-01 0.786 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.635691e-01 0.786 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.635691e-01 0.786 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.635691e-01 0.786 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.635691e-01 0.786 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 1.635691e-01 0.786 0 0
TICAM1 deficiency - HSE R-HSA-5602566 1.635691e-01 0.786 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.635691e-01 0.786 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 1.635691e-01 0.786 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.635691e-01 0.786 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.635691e-01 0.786 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.635691e-01 0.786 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.608012e-01 0.794 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.608012e-01 0.794 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.364209e-01 0.865 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.364209e-01 0.865 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.364209e-01 0.865 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.526066e-01 0.816 0 0
Deadenylation of mRNA R-HSA-429947 1.338019e-01 0.874 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 1.472391e-01 0.832 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 1.612229e-01 0.793 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.398676e-01 0.854 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.518063e-01 0.819 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.319043e-01 0.880 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.526066e-01 0.816 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 1.319043e-01 0.880 0 0
Signaling by ERBB2 R-HSA-1227986 1.598972e-01 0.796 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 1.398676e-01 0.854 0 0
Myogenesis R-HSA-525793 1.612229e-01 0.793 0 0
Integration of provirus R-HSA-162592 1.520067e-01 0.818 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.530584e-01 0.815 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.608012e-01 0.794 0 0
HIV Life Cycle R-HSA-162587 1.614501e-01 0.792 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.635691e-01 0.786 0 0
Proton/oligopeptide cotransporters R-HSA-427975 1.608012e-01 0.794 0 0
Autophagy R-HSA-9612973 1.557147e-01 0.808 0 0
Long-term potentiation R-HSA-9620244 1.472391e-01 0.832 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.598972e-01 0.796 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.560288e-01 0.807 0 0
Cell-cell junction organization R-HSA-421270 1.394708e-01 0.856 0 0
TGFBR3 expression R-HSA-9839394 1.472391e-01 0.832 0 0
Signaling by Hippo R-HSA-2028269 1.364209e-01 0.865 0 0
Axon guidance R-HSA-422475 1.593860e-01 0.798 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.520067e-01 0.818 0 0
Inositol phosphate metabolism R-HSA-1483249 1.504953e-01 0.822 0 0
Signaling by ROBO receptors R-HSA-376176 1.456106e-01 0.837 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.526066e-01 0.816 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 1.552595e-01 0.809 1 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 1.641807e-01 0.785 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 1.641807e-01 0.785 0 0
Nuclear import of Rev protein R-HSA-180746 1.641807e-01 0.785 0 0
TRAF3 deficiency - HSE R-HSA-5602571 2.350351e-01 0.629 0 0
Defective GALE causes EDG R-HSA-5609977 2.350351e-01 0.629 0 0
Defective VWF binding to collagen type I R-HSA-9845622 2.350351e-01 0.629 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.350351e-01 0.629 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 2.350351e-01 0.629 0 0
Defective ALG9 causes CDG-1l R-HSA-4720454 3.003989e-01 0.522 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 3.003989e-01 0.522 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 3.003989e-01 0.522 0 0
Defective DHDDS causes RP59 R-HSA-4755609 3.003989e-01 0.522 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.003989e-01 0.522 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.003989e-01 0.522 0 0
HHAT G278V doesn't palmitoylate Hh-Np R-HSA-5658034 3.003989e-01 0.522 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.003989e-01 0.522 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 1.925192e-01 0.716 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 3.601810e-01 0.443 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 3.601810e-01 0.443 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.601810e-01 0.443 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 3.601810e-01 0.443 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 3.601810e-01 0.443 0 0
MET activates PTPN11 R-HSA-8865999 3.601810e-01 0.443 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.601810e-01 0.443 0 0
Invadopodia formation R-HSA-8941237 3.601810e-01 0.443 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.601810e-01 0.443 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.734354e-01 0.761 0 0
MET receptor recycling R-HSA-8875656 2.577283e-01 0.589 0 0
Formation of annular gap junctions R-HSA-196025 2.577283e-01 0.589 0 0
Formation of axial mesoderm R-HSA-9796292 1.956464e-01 0.709 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 1.694743e-01 0.771 0 0
Lipophagy R-HSA-9613354 2.905699e-01 0.537 0 0
Gap junction degradation R-HSA-190873 2.905699e-01 0.537 0 0
Regulation of gap junction activity R-HSA-191650 4.148579e-01 0.382 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 4.148579e-01 0.382 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.148579e-01 0.382 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.148579e-01 0.382 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 4.148579e-01 0.382 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.148579e-01 0.382 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 2.049881e-01 0.688 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 2.049881e-01 0.688 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 1.757170e-01 0.755 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.757170e-01 0.755 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 2.655980e-01 0.576 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 1.769678e-01 0.752 0 0
Late endosomal microautophagy R-HSA-9615710 2.060817e-01 0.686 0 0
Disorders of Developmental Biology R-HSA-9675151 2.895948e-01 0.538 0 0
NrCAM interactions R-HSA-447038 4.648653e-01 0.333 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 4.648653e-01 0.333 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 4.648653e-01 0.333 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 4.648653e-01 0.333 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.218717e-01 0.654 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 3.137370e-01 0.503 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.380119e-01 0.623 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.380119e-01 0.623 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.812185e-01 0.551 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 3.871619e-01 0.412 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 3.871619e-01 0.412 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 3.871619e-01 0.412 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.871619e-01 0.412 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 3.379204e-01 0.471 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 3.379204e-01 0.471 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.711753e-01 0.567 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.881152e-01 0.540 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.181423e-01 0.379 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.181423e-01 0.379 0 0
Disorders of Nervous System Development R-HSA-9697154 4.181423e-01 0.379 0 0
Pervasive developmental disorders R-HSA-9005895 4.181423e-01 0.379 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 4.181423e-01 0.379 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 5.106017e-01 0.292 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.106017e-01 0.292 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.106017e-01 0.292 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.106017e-01 0.292 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.106017e-01 0.292 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.106017e-01 0.292 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.106017e-01 0.292 0 0
Dual Incision in GG-NER R-HSA-5696400 3.052390e-01 0.515 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.408621e-01 0.467 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.408621e-01 0.467 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 3.860365e-01 0.413 0 0
snRNP Assembly R-HSA-191859 2.534065e-01 0.596 0 0
Metabolism of non-coding RNA R-HSA-194441 2.534065e-01 0.596 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.982613e-01 0.703 0 0
Telomere Extension By Telomerase R-HSA-171319 3.608873e-01 0.443 0 0
HIV elongation arrest and recovery R-HSA-167287 3.608873e-01 0.443 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.608873e-01 0.443 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.398782e-01 0.469 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.098034e-01 0.387 0 0
Formation of a pool of free 40S subunits R-HSA-72689 2.438354e-01 0.613 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 4.332795e-01 0.363 0 0
Non-canonical inflammasome activation R-HSA-9686114 4.775664e-01 0.321 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.524316e-01 0.258 0 0
G2/M DNA replication checkpoint R-HSA-69478 5.524316e-01 0.258 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 5.524316e-01 0.258 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 5.524316e-01 0.258 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.524316e-01 0.258 0 0
Signaling by ERBB4 R-HSA-1236394 3.135992e-01 0.504 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.298489e-01 0.482 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.479677e-01 0.458 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 4.564021e-01 0.341 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 4.403022e-01 0.356 0 0
Erythropoietin activates RAS R-HSA-9027284 5.058576e-01 0.296 0 0
G beta:gamma signalling through BTK R-HSA-8964315 5.058576e-01 0.296 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.761017e-01 0.425 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.227868e-01 0.374 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 5.331316e-01 0.273 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 5.906885e-01 0.229 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.906885e-01 0.229 0 0
TRIF-mediated programmed cell death R-HSA-2562578 5.906885e-01 0.229 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 5.906885e-01 0.229 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 5.906885e-01 0.229 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 5.906885e-01 0.229 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 5.906885e-01 0.229 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.621750e-01 0.335 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 5.231348e-01 0.281 0 0
G protein gated Potassium channels R-HSA-1296059 5.231348e-01 0.281 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 5.231348e-01 0.281 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.927374e-01 0.307 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.593557e-01 0.252 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.078027e-01 0.294 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 4.855679e-01 0.314 0 0
HCMV Early Events R-HSA-9609690 4.576890e-01 0.339 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.280265e-01 0.277 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.319888e-01 0.274 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.441226e-01 0.264 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.650311e-01 0.248 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.650311e-01 0.248 0 0
Type I hemidesmosome assembly R-HSA-446107 6.256773e-01 0.204 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 6.256773e-01 0.204 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.256773e-01 0.204 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.256773e-01 0.204 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 5.354757e-01 0.271 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 5.851145e-01 0.233 0 0
GAB1 signalosome R-HSA-180292 6.085859e-01 0.216 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 6.085859e-01 0.216 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 5.933875e-01 0.227 0 0
Signaling by Erythropoietin R-HSA-9006335 6.045952e-01 0.219 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.043848e-01 0.219 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.128359e-01 0.213 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 6.203433e-01 0.207 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.315839e-01 0.200 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 6.315839e-01 0.200 0 0
ARMS-mediated activation R-HSA-170984 6.576772e-01 0.182 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 6.346470e-01 0.197 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 6.366696e-01 0.196 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.521545e-01 0.186 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.535123e-01 0.185 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.853526e-01 0.545 0 0
RNA Polymerase III Transcription R-HSA-74158 3.398782e-01 0.469 0 0
EGFR downregulation R-HSA-182971 4.206456e-01 0.376 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.208706e-01 0.494 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 2.745266e-01 0.561 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 2.745266e-01 0.561 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 2.745266e-01 0.561 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.508671e-01 0.601 0 0
HIV Transcription Elongation R-HSA-167169 6.043848e-01 0.219 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.008279e-01 0.397 0 0
Signaling by NOTCH1 R-HSA-1980143 4.757308e-01 0.323 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 3.137370e-01 0.503 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 3.860365e-01 0.413 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 5.013742e-01 0.300 0 0
Ribosome-associated quality control R-HSA-9948299 4.126890e-01 0.384 0 0
Extension of Telomeres R-HSA-180786 3.909782e-01 0.408 0 0
Termination of translesion DNA synthesis R-HSA-5656169 6.045952e-01 0.219 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.043848e-01 0.219 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.008279e-01 0.397 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 4.270158e-01 0.370 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 4.621750e-01 0.335 0 0
Cellular response to starvation R-HSA-9711097 5.053283e-01 0.296 0 0
DNA Damage Bypass R-HSA-73893 2.508671e-01 0.601 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 2.438354e-01 0.613 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.905699e-01 0.537 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.812185e-01 0.551 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.442631e-01 0.352 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 4.311643e-01 0.365 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 5.593557e-01 0.252 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 5.443634e-01 0.264 0 0
Clathrin-mediated endocytosis R-HSA-8856828 2.768308e-01 0.558 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.454734e-01 0.263 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.257655e-01 0.487 0 0
Ephrin signaling R-HSA-3928664 6.085859e-01 0.216 0 0
Interleukin-1 processing R-HSA-448706 2.905699e-01 0.537 0 0
PI3K/AKT activation R-HSA-198203 3.232213e-01 0.490 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 4.564021e-01 0.341 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.331316e-01 0.273 0 0
Eukaryotic Translation Termination R-HSA-72764 4.739260e-01 0.324 0 0
Peptide chain elongation R-HSA-156902 4.993422e-01 0.302 0 0
Regulation of mitotic cell cycle R-HSA-453276 5.587921e-01 0.253 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 5.587921e-01 0.253 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.876040e-01 0.231 0 0
Attenuation phase R-HSA-3371568 6.043848e-01 0.219 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.164881e-01 0.665 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.610852e-01 0.251 0 0
GP1b-IX-V activation signalling R-HSA-430116 6.576772e-01 0.182 0 0
Signaling by EGFR R-HSA-177929 2.174950e-01 0.663 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.734354e-01 0.761 0 0
Translesion Synthesis by POLH R-HSA-110320 3.620493e-01 0.441 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.181423e-01 0.379 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.106017e-01 0.292 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 3.398782e-01 0.469 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 2.340322e-01 0.631 0 0
CREB phosphorylation R-HSA-199920 5.524316e-01 0.258 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.058576e-01 0.296 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.058576e-01 0.296 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.256773e-01 0.204 0 0
DARPP-32 events R-HSA-180024 6.045952e-01 0.219 0 0
HSF1-dependent transactivation R-HSA-3371571 6.057119e-01 0.218 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.286243e-01 0.202 0 0
UCH proteinases R-HSA-5689603 3.380195e-01 0.471 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 2.430106e-01 0.614 0 0
Activation of HOX genes during differentiation R-HSA-5619507 2.430106e-01 0.614 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.769678e-01 0.752 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.181423e-01 0.379 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.181423e-01 0.379 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 4.979184e-01 0.303 0 0
Degradation of DVL R-HSA-4641258 5.528308e-01 0.257 0 0
Mitochondrial protein import R-HSA-1268020 5.941689e-01 0.226 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.045696e-01 0.297 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 2.175527e-01 0.662 0 0
Interleukin-6 signaling R-HSA-1059683 4.483060e-01 0.348 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 6.045952e-01 0.219 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 6.234596e-01 0.205 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.881152e-01 0.540 0 0
Adrenoceptors R-HSA-390696 2.577283e-01 0.589 0 0
Negative regulation of MET activity R-HSA-6807004 1.869575e-01 0.728 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.218717e-01 0.654 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 3.137370e-01 0.503 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.711753e-01 0.567 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.106017e-01 0.292 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.775664e-01 0.321 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.331316e-01 0.273 0 0
Killing mechanisms R-HSA-9664420 5.331316e-01 0.273 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.269441e-01 0.370 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.256773e-01 0.204 0 0
Late Phase of HIV Life Cycle R-HSA-162599 4.602120e-01 0.337 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.791163e-01 0.320 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 5.719343e-01 0.243 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.181423e-01 0.379 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.058576e-01 0.296 0 0
Signaling by NOTCH R-HSA-157118 6.291423e-01 0.201 0 0
Formation of definitive endoderm R-HSA-9823730 1.869575e-01 0.728 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 5.443634e-01 0.264 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.500559e-01 0.347 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.648653e-01 0.333 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 4.648653e-01 0.333 0 0
Activation of C3 and C5 R-HSA-174577 4.648653e-01 0.333 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.106017e-01 0.292 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.934473e-01 0.713 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.534065e-01 0.596 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.403022e-01 0.356 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 3.339475e-01 0.476 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.906885e-01 0.229 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.906885e-01 0.229 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 5.116838e-01 0.291 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.443634e-01 0.264 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.845100e-01 0.233 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 6.315839e-01 0.200 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 6.315839e-01 0.200 0 0
Mismatch Repair R-HSA-5358508 3.379204e-01 0.471 0 0
Interleukin-23 signaling R-HSA-9020933 6.256773e-01 0.204 0 0
Prolonged ERK activation events R-HSA-169893 5.331316e-01 0.273 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.609035e-01 0.584 0 0
TBC/RABGAPs R-HSA-8854214 3.062518e-01 0.514 0 0
Processive synthesis on the lagging strand R-HSA-69183 5.058576e-01 0.296 0 0
HSF1 activation R-HSA-3371511 5.348725e-01 0.272 0 0
Signaling by MET R-HSA-6806834 3.876426e-01 0.412 0 0
Signaling by WNT R-HSA-195721 3.358136e-01 0.474 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.685029e-01 0.329 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 5.650311e-01 0.248 0 0
EPH-Ephrin signaling R-HSA-2682334 2.070568e-01 0.684 0 0
Interleukin-27 signaling R-HSA-9020956 3.232213e-01 0.490 0 0
Signaling by NOTCH4 R-HSA-9013694 5.976493e-01 0.224 0 0
Membrane Trafficking R-HSA-199991 5.046761e-01 0.297 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.620493e-01 0.441 0 0
HIV Infection R-HSA-162906 2.914094e-01 0.535 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.903322e-01 0.310 0 0
Post NMDA receptor activation events R-HSA-438064 2.442486e-01 0.612 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.597573e-01 0.337 0 0
Synthesis of DNA R-HSA-69239 1.846178e-01 0.734 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.350351e-01 0.629 0 0
Transport of connexins along the secretory pathway R-HSA-190827 2.350351e-01 0.629 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.003989e-01 0.522 0 0
C6 deamination of adenosine R-HSA-75102 3.003989e-01 0.522 0 0
The IPAF inflammasome R-HSA-844623 3.601810e-01 0.443 0 0
MET interacts with TNS proteins R-HSA-8875513 3.601810e-01 0.443 0 0
The NLRP3 inflammasome R-HSA-844456 1.694743e-01 0.771 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 2.905699e-01 0.537 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.895948e-01 0.538 0 0
Reelin signalling pathway R-HSA-8866376 4.648653e-01 0.333 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 3.379204e-01 0.471 0 0
Presynaptic function of Kainate receptors R-HSA-500657 3.379204e-01 0.471 0 0
Synthesis of PS R-HSA-1483101 5.106017e-01 0.292 0 0
Phosphorylation of Emi1 R-HSA-176417 5.106017e-01 0.292 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 4.483060e-01 0.348 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 4.483060e-01 0.348 0 0
Orc1 removal from chromatin R-HSA-68949 2.916270e-01 0.535 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.573161e-01 0.447 0 0
Budding and maturation of HIV virion R-HSA-162588 4.206456e-01 0.376 0 0
Kinesins R-HSA-983189 4.053505e-01 0.392 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 4.789740e-01 0.320 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.331316e-01 0.273 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 5.116838e-01 0.291 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.771813e-01 0.239 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.803219e-01 0.236 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.941689e-01 0.226 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 6.045952e-01 0.219 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.486149e-01 0.188 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.280265e-01 0.277 0 0
NGF-stimulated transcription R-HSA-9031628 3.841811e-01 0.415 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 2.910070e-01 0.536 0 0
Ub-specific processing proteases R-HSA-5689880 2.035018e-01 0.691 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.443634e-01 0.264 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.402015e-01 0.356 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.184993e-01 0.661 0 0
Aggrephagy R-HSA-9646399 4.096662e-01 0.388 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.227868e-01 0.374 0 0
Signaling by FGFR in disease R-HSA-1226099 4.493615e-01 0.347 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 2.905699e-01 0.537 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.461928e-01 0.609 0 0
Signal Transduction R-HSA-162582 6.490791e-01 0.188 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.648653e-01 0.333 0 0
NRIF signals cell death from the nucleus R-HSA-205043 4.775664e-01 0.321 0 0
tRNA processing in the nucleus R-HSA-6784531 4.340333e-01 0.362 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.593557e-01 0.252 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 4.780414e-01 0.321 0 0
Selenocysteine synthesis R-HSA-2408557 5.427097e-01 0.265 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.283726e-01 0.368 0 0
Negative regulation of FLT3 R-HSA-9706369 2.655980e-01 0.576 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 4.197083e-01 0.377 0 0
Selective autophagy R-HSA-9663891 1.648603e-01 0.783 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.239107e-01 0.205 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 2.577283e-01 0.589 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.956464e-01 0.709 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.648653e-01 0.333 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.247271e-01 0.648 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.881152e-01 0.540 0 0
Signaling by LTK R-HSA-9842663 4.181423e-01 0.379 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 4.564021e-01 0.341 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.906885e-01 0.229 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 5.906885e-01 0.229 0 0
Heme assimilation R-HSA-9927020 5.593557e-01 0.252 0 0
Inflammasomes R-HSA-622312 3.608873e-01 0.443 0 0
Host Interactions of HIV factors R-HSA-162909 4.611286e-01 0.336 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 3.232213e-01 0.490 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.231348e-01 0.281 0 0
S Phase R-HSA-69242 2.354577e-01 0.628 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.777631e-01 0.556 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 1.956464e-01 0.709 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 4.648653e-01 0.333 0 0
Acyl chain remodelling of PS R-HSA-1482801 3.009695e-01 0.521 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 6.576772e-01 0.182 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.418593e-01 0.616 0 0
PERK regulates gene expression R-HSA-381042 5.165603e-01 0.287 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 5.845100e-01 0.233 0 0
HDMs demethylate histones R-HSA-3214842 3.009695e-01 0.521 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 2.673231e-01 0.573 0 0
Oligomerization of connexins into connexons R-HSA-190704 2.350351e-01 0.629 0 0
SLC-mediated transport of oligopeptides R-HSA-9959399 2.249456e-01 0.648 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.601810e-01 0.443 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 1.956464e-01 0.709 0 0
Sensory perception of sour taste R-HSA-9729555 4.148579e-01 0.382 0 0
Josephin domain DUBs R-HSA-5689877 3.232213e-01 0.490 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.234974e-01 0.651 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.895948e-01 0.538 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 3.554754e-01 0.449 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.881152e-01 0.540 0 0
Metalloprotease DUBs R-HSA-5689901 3.208706e-01 0.494 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.524316e-01 0.258 0 0
Interleukin-12 family signaling R-HSA-447115 3.563345e-01 0.448 0 0
VLDL clearance R-HSA-8964046 5.906885e-01 0.229 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 4.775221e-01 0.321 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 5.593557e-01 0.252 0 0
RET signaling R-HSA-8853659 5.348725e-01 0.272 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.650311e-01 0.248 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.845100e-01 0.233 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.256773e-01 0.204 0 0
SLC-mediated bile acid transport R-HSA-9958517 6.256773e-01 0.204 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 6.043848e-01 0.219 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.234596e-01 0.205 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.315839e-01 0.200 0 0
mRNA Editing R-HSA-75072 6.576772e-01 0.182 0 0
MAPK1 (ERK2) activation R-HSA-112411 6.576772e-01 0.182 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.896381e-01 0.722 0 0
Diseases of DNA repair R-HSA-9675135 2.120301e-01 0.674 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 2.161724e-01 0.665 0 0
Neurexins and neuroligins R-HSA-6794361 4.467156e-01 0.350 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.608873e-01 0.443 0 0
ISG15 antiviral mechanism R-HSA-1169408 3.257655e-01 0.487 0 0
Co-inhibition by PD-1 R-HSA-389948 4.903322e-01 0.310 0 0
Death Receptor Signaling R-HSA-73887 2.057394e-01 0.687 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.343259e-01 0.630 0 0
Mitophagy R-HSA-5205647 3.052390e-01 0.515 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 4.625146e-01 0.335 0 0
Protein hydroxylation R-HSA-9629569 3.860365e-01 0.413 0 0
Generic Transcription Pathway R-HSA-212436 3.562937e-01 0.448 1 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 5.166018e-01 0.287 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 3.232213e-01 0.490 0 0
Interleukin-37 signaling R-HSA-9008059 2.218717e-01 0.654 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.711753e-01 0.567 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 5.524316e-01 0.258 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.845100e-01 0.233 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 6.576772e-01 0.182 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 6.264218e-01 0.203 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 6.085859e-01 0.216 0 0
FLT3 signaling in disease R-HSA-9682385 5.348725e-01 0.272 0 0
Signaling by TGFB family members R-HSA-9006936 6.236760e-01 0.205 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 6.264218e-01 0.203 0 0
The AIM2 inflammasome R-HSA-844615 3.003989e-01 0.522 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 2.249456e-01 0.648 0 0
Regulation of KIT signaling R-HSA-1433559 2.184993e-01 0.661 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.332795e-01 0.363 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.524316e-01 0.258 0 0
NADPH regeneration R-HSA-389542 5.524316e-01 0.258 0 0
Interleukin-12 signaling R-HSA-9020591 3.380195e-01 0.471 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 4.270158e-01 0.370 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.331316e-01 0.273 0 0
Regulation of PTEN localization R-HSA-8948747 5.906885e-01 0.229 0 0
Passive transport by Aquaporins R-HSA-432047 5.593557e-01 0.252 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 6.256773e-01 0.204 0 0
Sodium/Proton exchangers R-HSA-425986 6.256773e-01 0.204 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.315839e-01 0.200 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 6.576772e-01 0.182 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 6.465402e-01 0.189 0 0
G1/S Transition R-HSA-69206 1.932491e-01 0.714 1 0
Protein-protein interactions at synapses R-HSA-6794362 5.892367e-01 0.230 0 0
Heme signaling R-HSA-9707616 5.941689e-01 0.226 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 3.996597e-01 0.398 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 5.650311e-01 0.248 0 0
Other interleukin signaling R-HSA-449836 6.315839e-01 0.200 0 0
Interleukin-35 Signalling R-HSA-8984722 4.181423e-01 0.379 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 1.734354e-01 0.761 0 0
Maturation of nucleoprotein R-HSA-9683610 4.483060e-01 0.348 0 0
Protein methylation R-HSA-8876725 5.058576e-01 0.296 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.564021e-01 0.341 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 6.315839e-01 0.200 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 6.576772e-01 0.182 0 0
Apoptosis R-HSA-109581 1.917934e-01 0.717 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 4.564021e-01 0.341 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.249456e-01 0.648 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.577283e-01 0.589 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.648653e-01 0.333 0 0
Basigin interactions R-HSA-210991 4.098034e-01 0.387 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.747834e-01 0.426 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.058576e-01 0.296 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.906885e-01 0.229 0 0
CHL1 interactions R-HSA-447041 5.906885e-01 0.229 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 5.280265e-01 0.277 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.576772e-01 0.182 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.576772e-01 0.182 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.576772e-01 0.182 0 0
Potential therapeutics for SARS R-HSA-9679191 5.351331e-01 0.272 0 0
Metabolism of folate and pterines R-HSA-196757 5.528308e-01 0.257 0 0
Interleukin-7 signaling R-HSA-1266695 3.009695e-01 0.521 0 0
Signaling by ALK R-HSA-201556 3.922447e-01 0.406 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.649603e-01 0.438 0 0
Neurodegenerative Diseases R-HSA-8863678 5.013742e-01 0.300 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.013742e-01 0.300 0 0
Signaling by TGFBR3 R-HSA-9839373 3.528235e-01 0.452 0 0
Influenza Infection R-HSA-168255 5.972600e-01 0.224 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 4.688929e-01 0.329 0 0
Cellular response to mitochondrial stress R-HSA-9840373 2.905699e-01 0.537 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.181423e-01 0.379 0 0
Pyroptosis R-HSA-5620971 3.608873e-01 0.443 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 3.922447e-01 0.406 0 0
NOD1/2 Signaling Pathway R-HSA-168638 4.979184e-01 0.303 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 5.650311e-01 0.248 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.851145e-01 0.233 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 6.535123e-01 0.185 0 0
FLT3 Signaling R-HSA-9607240 6.207436e-01 0.207 0 0
STING mediated induction of host immune responses R-HSA-1834941 6.315839e-01 0.200 0 0
ChREBP activates metabolic gene expression R-HSA-163765 3.554754e-01 0.449 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 4.270158e-01 0.370 0 0
Amyloid fiber formation R-HSA-977225 2.765493e-01 0.558 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.845100e-01 0.233 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.534061e-01 0.257 0 0
Neurofascin interactions R-HSA-447043 5.524316e-01 0.258 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 5.906885e-01 0.229 0 0
G1/S-Specific Transcription R-HSA-69205 5.348725e-01 0.272 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 5.183501e-01 0.285 0 0
Maturation of nucleoprotein R-HSA-9694631 6.315839e-01 0.200 0 0
RMTs methylate histone arginines R-HSA-3214858 3.216775e-01 0.493 0 0
Diseases of programmed cell death R-HSA-9645723 1.648603e-01 0.783 0 0
Polo-like kinase mediated events R-HSA-156711 6.085859e-01 0.216 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.479677e-01 0.458 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 5.593557e-01 0.252 0 0
Nephron development R-HSA-9831926 6.085859e-01 0.216 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.704141e-01 0.244 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.298489e-01 0.482 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.593557e-01 0.252 0 0
Signaling by Leptin R-HSA-2586552 3.232213e-01 0.490 0 0
Specification of primordial germ cells R-HSA-9827857 5.845100e-01 0.233 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.639111e-01 0.249 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.483060e-01 0.348 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.845100e-01 0.233 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.775664e-01 0.321 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.315839e-01 0.200 0 0
Response to metal ions R-HSA-5660526 5.593557e-01 0.252 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 4.648653e-01 0.333 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 6.085859e-01 0.216 0 0
Sensory processing of sound R-HSA-9659379 6.582392e-01 0.182 0 0
Inwardly rectifying K+ channels R-HSA-1296065 6.593046e-01 0.181 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 6.671919e-01 0.176 0 0
Signaling by FGFR4 R-HSA-5654743 6.671919e-01 0.176 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 6.671919e-01 0.176 0 0
Circadian clock R-HSA-9909396 6.694292e-01 0.174 0 0
PKR-mediated signaling R-HSA-9833482 6.696721e-01 0.174 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 6.718123e-01 0.173 0 0
Regulated Necrosis R-HSA-5218859 6.718123e-01 0.173 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.743859e-01 0.171 0 0
G-protein activation R-HSA-202040 6.743859e-01 0.171 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 6.743859e-01 0.171 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 6.743859e-01 0.171 0 0
Lagging Strand Synthesis R-HSA-69186 6.743859e-01 0.171 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.743859e-01 0.171 0 0
TNF signaling R-HSA-75893 6.755187e-01 0.170 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 6.756265e-01 0.170 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.762770e-01 0.170 0 0
G-protein beta:gamma signalling R-HSA-397795 6.762770e-01 0.170 0 0
Nuclear RNA decay R-HSA-9930044 6.762770e-01 0.170 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.762770e-01 0.170 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.762770e-01 0.170 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 6.762770e-01 0.170 0 0
Cardiogenesis R-HSA-9733709 6.762770e-01 0.170 0 0
PI Metabolism R-HSA-1483255 6.781377e-01 0.169 0 0
Muscle contraction R-HSA-397014 6.783359e-01 0.169 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.835026e-01 0.165 0 0
CASP4 inflammasome assembly R-HSA-9948001 6.869432e-01 0.163 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.869432e-01 0.163 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.869432e-01 0.163 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.869432e-01 0.163 0 0
Binding and entry of HIV virion R-HSA-173107 6.869432e-01 0.163 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 6.869432e-01 0.163 0 0
DNA replication initiation R-HSA-68952 6.869432e-01 0.163 0 0
Regulation of CDH11 function R-HSA-9762292 6.869432e-01 0.163 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.869432e-01 0.163 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.869432e-01 0.163 0 0
Pexophagy R-HSA-9664873 6.869432e-01 0.163 0 0
Receptor Mediated Mitophagy R-HSA-8934903 6.869432e-01 0.163 0 0
MAPK3 (ERK1) activation R-HSA-110056 6.869432e-01 0.163 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 6.869432e-01 0.163 0 0
Formation of apoptosome R-HSA-111458 6.869432e-01 0.163 0 0
Tandem pore domain potassium channels R-HSA-1296346 6.869432e-01 0.163 0 0
Regulation of the apoptosome activity R-HSA-9627069 6.869432e-01 0.163 0 0
Maturation of spike protein R-HSA-9683686 6.869432e-01 0.163 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 6.870964e-01 0.163 0 0
Viral mRNA Translation R-HSA-192823 6.879430e-01 0.162 0 0
IRS-mediated signalling R-HSA-112399 6.884451e-01 0.162 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.926160e-01 0.160 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.926160e-01 0.160 0 0
Miscellaneous transport and binding events R-HSA-5223345 6.926160e-01 0.160 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 6.942247e-01 0.158 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 6.942247e-01 0.158 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.942247e-01 0.158 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 6.942247e-01 0.158 0 0
Ribavirin ADME R-HSA-9755088 6.942247e-01 0.158 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 6.942247e-01 0.158 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.942247e-01 0.158 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.954677e-01 0.158 0 0
HCMV Infection R-HSA-9609646 6.957840e-01 0.158 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 6.959088e-01 0.157 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.959088e-01 0.157 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.959088e-01 0.157 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.959088e-01 0.157 0 0
Signaling by FGFR3 R-HSA-5654741 6.959088e-01 0.157 0 0
Somitogenesis R-HSA-9824272 6.959088e-01 0.157 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 6.959088e-01 0.157 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 6.959088e-01 0.157 0 0
Dual incision in TC-NER R-HSA-6782135 7.010170e-01 0.154 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.010170e-01 0.154 0 0
Signaling by NOTCH2 R-HSA-1980145 7.083249e-01 0.150 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.083249e-01 0.150 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 7.083249e-01 0.150 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.094634e-01 0.149 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.095850e-01 0.149 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.095850e-01 0.149 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.095850e-01 0.149 0 0
Signaling by RAS mutants R-HSA-6802949 7.095850e-01 0.149 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 7.095850e-01 0.149 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 7.095850e-01 0.149 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.130532e-01 0.147 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 7.130532e-01 0.147 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 7.130532e-01 0.147 0 0
Notch-HLH transcription pathway R-HSA-350054 7.130532e-01 0.147 0 0
LDL clearance R-HSA-8964038 7.130532e-01 0.147 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.130532e-01 0.147 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.130532e-01 0.147 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.130532e-01 0.147 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.137087e-01 0.146 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.137087e-01 0.146 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.137087e-01 0.146 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.137087e-01 0.146 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.137087e-01 0.146 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 7.137087e-01 0.146 0 0
vRNP Assembly R-HSA-192905 7.137087e-01 0.146 0 0
Signaling by APC mutants R-HSA-4839744 7.137087e-01 0.146 0 0
Synthesis of PI R-HSA-1483226 7.137087e-01 0.146 0 0
Bicarbonate transporters R-HSA-425381 7.137087e-01 0.146 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.137087e-01 0.146 0 0
Suppression of apoptosis R-HSA-9635465 7.137087e-01 0.146 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.137087e-01 0.146 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 7.179585e-01 0.144 0 0
Signaling by NTRKs R-HSA-166520 7.187903e-01 0.143 0 0
Synthesis of PC R-HSA-1483191 7.228068e-01 0.141 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.234095e-01 0.141 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.234095e-01 0.141 0 0
Signalling to ERKs R-HSA-187687 7.234095e-01 0.141 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 7.234095e-01 0.141 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.250914e-01 0.140 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.250914e-01 0.140 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.250914e-01 0.140 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.250914e-01 0.140 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.250914e-01 0.140 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.252787e-01 0.139 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 7.287631e-01 0.137 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.308989e-01 0.136 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.308989e-01 0.136 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.308989e-01 0.136 0 0
Interleukin receptor SHC signaling R-HSA-912526 7.308989e-01 0.136 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 7.308989e-01 0.136 0 0
Growth hormone receptor signaling R-HSA-982772 7.308989e-01 0.136 0 0
PTEN Regulation R-HSA-6807070 7.353026e-01 0.134 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.365935e-01 0.133 0 0
Aquaporin-mediated transport R-HSA-445717 7.365935e-01 0.133 0 0
Formation of paraxial mesoderm R-HSA-9793380 7.365935e-01 0.133 0 0
Calmodulin induced events R-HSA-111933 7.378778e-01 0.132 0 0
CaM pathway R-HSA-111997 7.378778e-01 0.132 0 0
Regulation of TP53 Degradation R-HSA-6804757 7.378778e-01 0.132 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.381874e-01 0.132 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 7.381874e-01 0.132 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.381874e-01 0.132 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 7.381874e-01 0.132 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 7.381874e-01 0.132 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 7.381874e-01 0.132 0 0
Activation of RAC1 R-HSA-428540 7.381874e-01 0.132 0 0
NF-kB is activated and signals survival R-HSA-209560 7.381874e-01 0.132 0 0
Signaling by AXIN mutants R-HSA-4839735 7.381874e-01 0.132 0 0
Signaling by AMER1 mutants R-HSA-4839748 7.381874e-01 0.132 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 7.381874e-01 0.132 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 7.381874e-01 0.132 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.381874e-01 0.132 0 0
Anchoring fibril formation R-HSA-2214320 7.381874e-01 0.132 0 0
DS-GAG biosynthesis R-HSA-2022923 7.381874e-01 0.132 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 7.381874e-01 0.132 0 0
XBP1(S) activates chaperone genes R-HSA-381038 7.428475e-01 0.129 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.477400e-01 0.126 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.477400e-01 0.126 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.477923e-01 0.126 0 0
Interleukin-6 family signaling R-HSA-6783589 7.477923e-01 0.126 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 7.477923e-01 0.126 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.477923e-01 0.126 0 0
Chemokine receptors bind chemokines R-HSA-380108 7.478971e-01 0.126 0 0
Centrosome maturation R-HSA-380287 7.494887e-01 0.125 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 7.517394e-01 0.124 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 7.517394e-01 0.124 0 0
Ovarian tumor domain proteases R-HSA-5689896 7.517394e-01 0.124 0 0
Collagen chain trimerization R-HSA-8948216 7.517394e-01 0.124 0 0
Chaperonin-mediated protein folding R-HSA-390466 7.523017e-01 0.124 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 7.585330e-01 0.120 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 7.585330e-01 0.120 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.585330e-01 0.120 0 0
Signaling by FGFR2 in disease R-HSA-5655253 7.597734e-01 0.119 0 0
PI3K Cascade R-HSA-109704 7.597734e-01 0.119 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 7.605744e-01 0.119 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 7.605744e-01 0.119 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.605744e-01 0.119 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.605744e-01 0.119 0 0
Scavenging by Class F Receptors R-HSA-3000484 7.605744e-01 0.119 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.605744e-01 0.119 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.605744e-01 0.119 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.605744e-01 0.119 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.605744e-01 0.119 0 0
MET activates RAS signaling R-HSA-8851805 7.605744e-01 0.119 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.605744e-01 0.119 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 7.605744e-01 0.119 0 0
p75NTR recruits signalling complexes R-HSA-209543 7.605744e-01 0.119 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 7.605744e-01 0.119 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.605744e-01 0.119 0 0
Regulation of IFNG signaling R-HSA-877312 7.605744e-01 0.119 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 7.605744e-01 0.119 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.605744e-01 0.119 0 0
Interleukin-15 signaling R-HSA-8983432 7.605744e-01 0.119 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 7.635325e-01 0.117 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.637657e-01 0.117 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.637657e-01 0.117 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.637657e-01 0.117 0 0
Tight junction interactions R-HSA-420029 7.637657e-01 0.117 0 0
Hyaluronan degradation R-HSA-2160916 7.637657e-01 0.117 0 0
MET promotes cell motility R-HSA-8875878 7.650057e-01 0.116 0 0
Insulin receptor signalling cascade R-HSA-74751 7.689752e-01 0.114 0 0
IGF1R signaling cascade R-HSA-2428924 7.689752e-01 0.114 0 0
Translation R-HSA-72766 7.699521e-01 0.114 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.712109e-01 0.113 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 7.776893e-01 0.109 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 7.776893e-01 0.109 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.776893e-01 0.109 0 0
Stabilization of p53 R-HSA-69541 7.776893e-01 0.109 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 7.776893e-01 0.109 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 7.776893e-01 0.109 0 0
PCP/CE pathway R-HSA-4086400 7.783815e-01 0.109 0 0
SARS-CoV-2-host interactions R-HSA-9705683 7.786658e-01 0.109 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 7.788529e-01 0.109 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.788529e-01 0.109 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.788529e-01 0.109 0 0
TRP channels R-HSA-3295583 7.788529e-01 0.109 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 7.790701e-01 0.108 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 7.810483e-01 0.107 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.810483e-01 0.107 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 7.810483e-01 0.107 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 7.810483e-01 0.107 0 0
Frs2-mediated activation R-HSA-170968 7.810483e-01 0.107 0 0
Reversible hydration of carbon dioxide R-HSA-1475029 7.810483e-01 0.107 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 7.810483e-01 0.107 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 7.810483e-01 0.107 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 7.822162e-01 0.107 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.822162e-01 0.107 0 0
AURKA Activation by TPX2 R-HSA-8854518 7.888216e-01 0.103 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 7.898042e-01 0.102 0 0
Diseases of Immune System R-HSA-5260271 7.898042e-01 0.102 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.898042e-01 0.102 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.898042e-01 0.102 0 0
Cristae formation R-HSA-8949613 7.930886e-01 0.101 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.930886e-01 0.101 0 0
Signaling by BMP R-HSA-201451 7.930886e-01 0.101 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 7.930886e-01 0.101 0 0
Triglyceride biosynthesis R-HSA-75109 7.930886e-01 0.101 0 0
Synthesis of PE R-HSA-1483213 7.930886e-01 0.101 0 0
IRE1alpha activates chaperones R-HSA-381070 7.958320e-01 0.099 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.977552e-01 0.098 0 0
Retrograde neurotrophin signalling R-HSA-177504 7.997726e-01 0.097 0 0
Removal of the Flap Intermediate R-HSA-69166 7.997726e-01 0.097 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 7.997726e-01 0.097 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 7.997726e-01 0.097 0 0
CRMPs in Sema3A signaling R-HSA-399956 7.997726e-01 0.097 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.997726e-01 0.097 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 7.997726e-01 0.097 0 0
Malate-aspartate shuttle R-HSA-9856872 7.997726e-01 0.097 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.997726e-01 0.097 0 0
Signal regulatory protein family interactions R-HSA-391160 7.997726e-01 0.097 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.013649e-01 0.096 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.013649e-01 0.096 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 8.013649e-01 0.096 0 0
Intracellular signaling by second messengers R-HSA-9006925 8.028063e-01 0.095 0 0
Protein folding R-HSA-391251 8.038013e-01 0.095 0 0
Opioid Signalling R-HSA-111885 8.040529e-01 0.095 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 8.065080e-01 0.093 0 0
Formation of the Early Elongation Complex R-HSA-113418 8.065080e-01 0.093 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.065080e-01 0.093 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 8.065080e-01 0.093 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 8.065080e-01 0.093 0 0
Transcription of the HIV genome R-HSA-167172 8.073141e-01 0.093 0 0
Gastrulation R-HSA-9758941 8.108050e-01 0.091 0 0
MAP2K and MAPK activation R-HSA-5674135 8.123871e-01 0.090 0 0
Signaling by RAF1 mutants R-HSA-9656223 8.123871e-01 0.090 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.123871e-01 0.090 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 8.123871e-01 0.090 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.123871e-01 0.090 0 0
Translation of Structural Proteins R-HSA-9683701 8.123871e-01 0.090 0 0
Signaling by NOTCH3 R-HSA-9012852 8.127150e-01 0.090 0 0
G2/M Transition R-HSA-69275 8.129957e-01 0.090 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 8.168966e-01 0.088 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 8.168966e-01 0.088 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.168966e-01 0.088 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 8.168966e-01 0.088 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.168966e-01 0.088 0 0
Translesion synthesis by REV1 R-HSA-110312 8.168966e-01 0.088 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.168966e-01 0.088 0 0
p75NTR signals via NF-kB R-HSA-193639 8.168966e-01 0.088 0 0
DCC mediated attractive signaling R-HSA-418885 8.168966e-01 0.088 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 8.168966e-01 0.088 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.168966e-01 0.088 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.168966e-01 0.088 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.168966e-01 0.088 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 8.168966e-01 0.088 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.168966e-01 0.088 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 8.168966e-01 0.088 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.191467e-01 0.087 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.191467e-01 0.087 0 0
Glucagon-type ligand receptors R-HSA-420092 8.191467e-01 0.087 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.208355e-01 0.086 0 0
Unfolded Protein Response (UPR) R-HSA-381119 8.209803e-01 0.086 0 0
Signaling by FGFR1 R-HSA-5654736 8.220709e-01 0.085 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 8.220709e-01 0.085 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.228868e-01 0.085 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 8.228868e-01 0.085 0 0
Activation of GABAB receptors R-HSA-991365 8.228868e-01 0.085 0 0
GABA B receptor activation R-HSA-977444 8.228868e-01 0.085 0 0
Ca-dependent events R-HSA-111996 8.228868e-01 0.085 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.228868e-01 0.085 0 0
Mitotic G2-G2/M phases R-HSA-453274 8.236829e-01 0.084 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.238390e-01 0.084 0 0
Regulation of CDH1 Function R-HSA-9764561 8.310373e-01 0.080 0 0
DAP12 signaling R-HSA-2424491 8.310399e-01 0.080 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 8.310399e-01 0.080 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.310399e-01 0.080 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 8.310399e-01 0.080 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.310399e-01 0.080 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.325571e-01 0.080 0 0
Translesion synthesis by POLI R-HSA-5656121 8.325571e-01 0.080 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.325571e-01 0.080 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.325571e-01 0.080 0 0
Phase 4 - resting membrane potential R-HSA-5576886 8.325571e-01 0.080 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 8.325571e-01 0.080 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.325571e-01 0.080 0 0
Activation of SMO R-HSA-5635838 8.325571e-01 0.080 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.325571e-01 0.080 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.325571e-01 0.080 0 0
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534 8.325571e-01 0.080 0 0
Attachment and Entry R-HSA-9678110 8.325571e-01 0.080 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 8.325571e-01 0.080 0 0
Virus Assembly and Release R-HSA-168268 8.325571e-01 0.080 0 0
Hedgehog 'on' state R-HSA-5632684 8.326099e-01 0.080 0 0
Signaling by SCF-KIT R-HSA-1433557 8.328806e-01 0.079 0 0
Protein localization R-HSA-9609507 8.339285e-01 0.079 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 8.359055e-01 0.078 0 0
COPI-mediated anterograde transport R-HSA-6807878 8.401065e-01 0.076 0 0
Trafficking of AMPA receptors R-HSA-399719 8.422227e-01 0.075 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 8.422227e-01 0.075 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 8.422227e-01 0.075 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.422227e-01 0.075 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.422227e-01 0.075 0 0
Amine ligand-binding receptors R-HSA-375280 8.423853e-01 0.074 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.423853e-01 0.074 0 0
Translesion synthesis by POLK R-HSA-5655862 8.468790e-01 0.072 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.468790e-01 0.072 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 8.468790e-01 0.072 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 8.468790e-01 0.072 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 8.468790e-01 0.072 0 0
Fibronectin matrix formation R-HSA-1566977 8.468790e-01 0.072 0 0
Synthesis of PG R-HSA-1483148 8.468790e-01 0.072 0 0
Galactose catabolism R-HSA-70370 8.468790e-01 0.072 0 0
Coenzyme A biosynthesis R-HSA-196783 8.468790e-01 0.072 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 8.468790e-01 0.072 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 8.468790e-01 0.072 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.478416e-01 0.072 0 0
Triglyceride metabolism R-HSA-8979227 8.478416e-01 0.072 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.479194e-01 0.072 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 8.514180e-01 0.070 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 8.514180e-01 0.070 0 0
DAG and IP3 signaling R-HSA-1489509 8.514180e-01 0.070 0 0
Cellular response to chemical stress R-HSA-9711123 8.514576e-01 0.070 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.527297e-01 0.069 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 8.527297e-01 0.069 0 0
G0 and Early G1 R-HSA-1538133 8.527297e-01 0.069 0 0
Post-translational protein phosphorylation R-HSA-8957275 8.530405e-01 0.069 0 0
HCMV Late Events R-HSA-9610379 8.548381e-01 0.068 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 8.599767e-01 0.066 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.599767e-01 0.066 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 8.599767e-01 0.066 0 0
Glycogen storage diseases R-HSA-3229121 8.599767e-01 0.066 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.599767e-01 0.066 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.599767e-01 0.066 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 8.599767e-01 0.066 0 0
Choline catabolism R-HSA-6798163 8.599767e-01 0.066 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.608148e-01 0.065 0 0
MHC class II antigen presentation R-HSA-2132295 8.608148e-01 0.065 0 0
Integrin signaling R-HSA-354192 8.625944e-01 0.064 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.625944e-01 0.064 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.625944e-01 0.064 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.625944e-01 0.064 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.625944e-01 0.064 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 8.629743e-01 0.064 0 0
PLC beta mediated events R-HSA-112043 8.632110e-01 0.064 0 0
Neddylation R-HSA-8951664 8.643517e-01 0.063 0 0
Hedgehog 'off' state R-HSA-5610787 8.651141e-01 0.063 0 0
Glycolysis R-HSA-70171 8.651141e-01 0.063 0 0
Signaling by Interleukins R-HSA-449147 8.655640e-01 0.063 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.679866e-01 0.061 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.681360e-01 0.061 0 0
Recycling pathway of L1 R-HSA-437239 8.681360e-01 0.061 0 0
ER-Phagosome pathway R-HSA-1236974 8.691327e-01 0.061 0 0
SARS-CoV Infections R-HSA-9679506 8.716434e-01 0.060 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.718500e-01 0.060 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.718500e-01 0.060 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.719547e-01 0.060 0 0
Transport of connexons to the plasma membrane R-HSA-190872 8.719547e-01 0.060 0 0
PKA activation R-HSA-163615 8.719547e-01 0.060 0 0
PKA activation in glucagon signalling R-HSA-164378 8.719547e-01 0.060 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.719547e-01 0.060 0 0
Tie2 Signaling R-HSA-210993 8.719547e-01 0.060 0 0
Synaptic adhesion-like molecules R-HSA-8849932 8.719547e-01 0.060 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 8.719547e-01 0.060 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 8.719547e-01 0.060 0 0
Apoptotic factor-mediated response R-HSA-111471 8.719547e-01 0.060 0 0
Vesicle-mediated transport R-HSA-5653656 8.735540e-01 0.059 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 8.748401e-01 0.058 0 0
GPER1 signaling R-HSA-9634597 8.758556e-01 0.058 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.805283e-01 0.055 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.805283e-01 0.055 0 0
Signal amplification R-HSA-392518 8.805283e-01 0.055 0 0
RAF activation R-HSA-5673000 8.805283e-01 0.055 0 0
eNOS activation R-HSA-203615 8.805283e-01 0.055 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.805283e-01 0.055 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.805283e-01 0.055 0 0
Hyaluronan metabolism R-HSA-2142845 8.805283e-01 0.055 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.805283e-01 0.055 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.805283e-01 0.055 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 8.829088e-01 0.054 0 0
Regulation of signaling by CBL R-HSA-912631 8.829088e-01 0.054 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 8.829088e-01 0.054 0 0
Crosslinking of collagen fibrils R-HSA-2243919 8.829088e-01 0.054 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 8.829088e-01 0.054 0 0
Pyrimidine biosynthesis R-HSA-500753 8.829088e-01 0.054 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.829088e-01 0.054 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.829088e-01 0.054 0 0
E2F mediated regulation of DNA replication R-HSA-113510 8.829088e-01 0.054 0 0
Diseases of hemostasis R-HSA-9671793 8.829088e-01 0.054 0 0
Specification of the neural plate border R-HSA-9834899 8.829088e-01 0.054 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.831715e-01 0.054 0 0
Degradation of CDH1 R-HSA-9766229 8.831715e-01 0.054 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 8.831715e-01 0.054 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 8.831715e-01 0.054 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 8.834636e-01 0.054 0 0
Selenoamino acid metabolism R-HSA-2408522 8.864123e-01 0.052 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.868205e-01 0.052 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.886604e-01 0.051 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.886604e-01 0.051 0 0
Oncogene Induced Senescence R-HSA-2559585 8.886604e-01 0.051 0 0
Regulation of Apoptosis R-HSA-169911 8.886604e-01 0.051 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.901005e-01 0.051 0 0
Signaling by FGFR2 R-HSA-5654738 8.926175e-01 0.049 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.926175e-01 0.049 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 8.929263e-01 0.049 0 0
Glycogen synthesis R-HSA-3322077 8.929263e-01 0.049 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.929263e-01 0.049 0 0
Creatine metabolism R-HSA-71288 8.929263e-01 0.049 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.929263e-01 0.049 0 0
Pregnenolone biosynthesis R-HSA-196108 8.929263e-01 0.049 0 0
Nephrin family interactions R-HSA-373753 8.929263e-01 0.049 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.959214e-01 0.048 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 8.962763e-01 0.048 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.962763e-01 0.048 0 0
Triglyceride catabolism R-HSA-163560 8.962763e-01 0.048 0 0
Rab regulation of trafficking R-HSA-9007101 8.974103e-01 0.047 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.989057e-01 0.046 0 0
Phospholipid metabolism R-HSA-1483257 9.005064e-01 0.046 0 0
G-protein mediated events R-HSA-112040 9.015707e-01 0.045 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.020874e-01 0.045 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 9.020874e-01 0.045 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 9.020874e-01 0.045 0 0
Signalling to RAS R-HSA-167044 9.020874e-01 0.045 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.020874e-01 0.045 0 0
Abacavir metabolism R-HSA-2161541 9.020874e-01 0.045 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 9.020874e-01 0.045 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.020874e-01 0.045 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.028633e-01 0.044 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 9.034046e-01 0.044 0 0
Degradation of AXIN R-HSA-4641257 9.034046e-01 0.044 0 0
NCAM1 interactions R-HSA-419037 9.034046e-01 0.044 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 9.046733e-01 0.044 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.060652e-01 0.043 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.087290e-01 0.042 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.094625e-01 0.041 0 0
Stimuli-sensing channels R-HSA-2672351 9.097584e-01 0.041 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.100730e-01 0.041 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.100730e-01 0.041 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.104651e-01 0.041 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 9.104651e-01 0.041 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 9.104651e-01 0.041 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 9.104651e-01 0.041 0 0
Serine metabolism R-HSA-977347 9.104651e-01 0.041 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.104651e-01 0.041 0 0
Attachment and Entry R-HSA-9694614 9.104651e-01 0.041 0 0
Assembly Of The HIV Virion R-HSA-175474 9.104651e-01 0.041 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.163081e-01 0.038 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 9.163081e-01 0.038 0 0
FGFR2 alternative splicing R-HSA-6803529 9.181265e-01 0.037 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.181265e-01 0.037 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 9.181265e-01 0.037 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 9.181265e-01 0.037 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.181265e-01 0.037 0 0
Cholesterol biosynthesis via lathosterol R-HSA-6807062 9.181265e-01 0.037 0 0
Signaling by KIT in disease R-HSA-9669938 9.181265e-01 0.037 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 9.195060e-01 0.036 0 0
G alpha (z) signalling events R-HSA-418597 9.195060e-01 0.036 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 9.214218e-01 0.036 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 9.215451e-01 0.035 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 9.221351e-01 0.035 0 0
Generation of second messenger molecules R-HSA-202433 9.221351e-01 0.035 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 9.221351e-01 0.035 0 0
Interleukin-2 family signaling R-HSA-451927 9.221351e-01 0.035 0 0
Regulation of insulin secretion R-HSA-422356 9.228365e-01 0.035 0 0
Ion homeostasis R-HSA-5578775 9.244469e-01 0.034 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 9.251327e-01 0.034 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 9.251327e-01 0.034 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.251327e-01 0.034 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 9.251327e-01 0.034 0 0
Interleukin-20 family signaling R-HSA-8854691 9.251327e-01 0.034 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 9.251327e-01 0.034 0 0
Carnitine shuttle R-HSA-200425 9.251327e-01 0.034 0 0
Syndecan interactions R-HSA-3000170 9.251327e-01 0.034 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.259338e-01 0.033 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.275782e-01 0.033 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.285869e-01 0.032 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 9.291084e-01 0.032 0 0
Ca2+ pathway R-HSA-4086398 9.301001e-01 0.031 0 0
ABC-family proteins mediated transport R-HSA-382556 9.301925e-01 0.031 0 0
Developmental Biology R-HSA-1266738 9.307382e-01 0.031 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.309226e-01 0.031 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 9.315398e-01 0.031 0 0
Synthesis of dolichyl-phosphate R-HSA-446199 9.315398e-01 0.031 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.315398e-01 0.031 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 9.326603e-01 0.030 0 0
HIV Transcription Initiation R-HSA-167161 9.326603e-01 0.030 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 9.326603e-01 0.030 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.326603e-01 0.030 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.326603e-01 0.030 0 0
Negative regulation of MAPK pathway R-HSA-5675221 9.326603e-01 0.030 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 9.326603e-01 0.030 0 0
MAPK family signaling cascades R-HSA-5683057 9.331579e-01 0.030 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.335041e-01 0.030 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 9.336329e-01 0.030 0 0
Signaling by Hedgehog R-HSA-5358351 9.338707e-01 0.030 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 9.344392e-01 0.029 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.350986e-01 0.029 0 0
Interleukin-1 family signaling R-HSA-446652 9.367878e-01 0.028 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 9.373989e-01 0.028 0 0
Regulation of beta-cell development R-HSA-186712 9.376472e-01 0.028 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.378031e-01 0.028 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 9.399669e-01 0.027 0 0
Viral Infection Pathways R-HSA-9824446 9.407279e-01 0.027 0 0
tRNA Aminoacylation R-HSA-379724 9.415505e-01 0.026 0 0
GABA receptor activation R-HSA-977443 9.415505e-01 0.026 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.415505e-01 0.026 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.418284e-01 0.026 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.418284e-01 0.026 0 0
MET activates PTK2 signaling R-HSA-8874081 9.427568e-01 0.026 0 0
Urea cycle R-HSA-70635 9.427568e-01 0.026 0 0
Abacavir ADME R-HSA-2161522 9.427568e-01 0.026 0 0
Sphingolipid catabolism R-HSA-9845614 9.427568e-01 0.026 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 9.427568e-01 0.026 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 9.427568e-01 0.026 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.427568e-01 0.026 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.427568e-01 0.026 0 0
L1CAM interactions R-HSA-373760 9.438862e-01 0.025 0 0
Collagen degradation R-HSA-1442490 9.452262e-01 0.024 0 0
Gap junction trafficking R-HSA-190828 9.459548e-01 0.024 0 0
Proteasome assembly R-HSA-9907900 9.459548e-01 0.024 0 0
DAP12 interactions R-HSA-2172127 9.459548e-01 0.024 0 0
Surfactant metabolism R-HSA-5683826 9.459548e-01 0.024 0 0
Netrin-1 signaling R-HSA-373752 9.459548e-01 0.024 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.459548e-01 0.024 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.461403e-01 0.024 0 0
Glucose metabolism R-HSA-70326 9.465713e-01 0.024 0 0
Developmental Cell Lineages R-HSA-9734767 9.469557e-01 0.024 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 9.476565e-01 0.023 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 9.476565e-01 0.023 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 9.476565e-01 0.023 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.476565e-01 0.023 0 0
Insulin processing R-HSA-264876 9.476565e-01 0.023 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.476565e-01 0.023 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.479172e-01 0.023 0 0
Integrin cell surface interactions R-HSA-216083 9.479172e-01 0.023 0 0
Signaling by PDGF R-HSA-186797 9.486861e-01 0.023 0 0
tRNA processing R-HSA-72306 9.489677e-01 0.023 0 0
Signaling by Insulin receptor R-HSA-74752 9.491056e-01 0.023 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.498014e-01 0.022 0 0
Adipogenesis R-HSA-9843745 9.501875e-01 0.022 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.519415e-01 0.021 0 0
Pyrimidine salvage R-HSA-73614 9.521371e-01 0.021 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 9.533857e-01 0.021 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.533857e-01 0.021 0 0
Ion transport by P-type ATPases R-HSA-936837 9.550032e-01 0.020 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.561553e-01 0.019 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.561553e-01 0.019 0 0
mRNA Capping R-HSA-72086 9.562344e-01 0.019 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.562344e-01 0.019 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.562344e-01 0.019 0 0
Platelet calcium homeostasis R-HSA-418360 9.562344e-01 0.019 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.562344e-01 0.019 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.565026e-01 0.019 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.567245e-01 0.019 0 0
ER to Golgi Anterograde Transport R-HSA-199977 9.578183e-01 0.019 0 0
Transmission across Chemical Synapses R-HSA-112315 9.581552e-01 0.019 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.584203e-01 0.018 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.588048e-01 0.018 0 0
Neurotransmitter clearance R-HSA-112311 9.599811e-01 0.018 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.599811e-01 0.018 0 0
Activation of BH3-only proteins R-HSA-114452 9.599811e-01 0.018 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.615690e-01 0.017 0 0
Integration of energy metabolism R-HSA-163685 9.626490e-01 0.017 0 0
Gap junction trafficking and regulation R-HSA-157858 9.627278e-01 0.016 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 9.634073e-01 0.016 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.634073e-01 0.016 0 0
Cargo concentration in the ER R-HSA-5694530 9.634073e-01 0.016 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.634073e-01 0.016 0 0
Downstream signal transduction R-HSA-186763 9.634073e-01 0.016 0 0
Neutrophil degranulation R-HSA-6798695 9.637033e-01 0.016 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.655142e-01 0.015 0 0
Signaling by FGFR R-HSA-190236 9.657177e-01 0.015 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.657177e-01 0.015 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.657177e-01 0.015 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.657177e-01 0.015 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 9.663696e-01 0.015 0 0
Signaling by WNT in cancer R-HSA-4791275 9.665404e-01 0.015 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.666040e-01 0.015 0 0
Complex IV assembly R-HSA-9864848 9.679266e-01 0.014 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 9.679266e-01 0.014 0 0
The phototransduction cascade R-HSA-2514856 9.679266e-01 0.014 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.698566e-01 0.013 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 9.702567e-01 0.013 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.708051e-01 0.013 0 0
Interleukin-1 signaling R-HSA-9020702 9.711717e-01 0.013 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 9.715196e-01 0.013 0 0
Metabolism of cofactors R-HSA-8978934 9.718286e-01 0.012 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.720251e-01 0.012 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.720251e-01 0.012 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.720251e-01 0.012 0 0
Heme degradation R-HSA-189483 9.720251e-01 0.012 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.724232e-01 0.012 0 0
Purine catabolism R-HSA-74259 9.736780e-01 0.012 0 0
Gap junction assembly R-HSA-190861 9.744208e-01 0.011 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.744208e-01 0.011 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.744208e-01 0.011 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.744208e-01 0.011 0 0
Neurotransmitter release cycle R-HSA-112310 9.765528e-01 0.010 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.766114e-01 0.010 0 0
RSV-host interactions R-HSA-9833110 9.771968e-01 0.010 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.780465e-01 0.010 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.780465e-01 0.010 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.784210e-01 0.009 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.784210e-01 0.009 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.785077e-01 0.009 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.785589e-01 0.009 0 0
GPVI-mediated activation cascade R-HSA-114604 9.786145e-01 0.009 0 0
Glycosphingolipid transport R-HSA-9845576 9.786145e-01 0.009 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.786145e-01 0.009 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.786145e-01 0.009 0 0
Interferon Signaling R-HSA-913531 9.794240e-01 0.009 0 0
Synthesis of PA R-HSA-1483166 9.796611e-01 0.009 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.804462e-01 0.009 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.804462e-01 0.009 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.813198e-01 0.008 0 0
Translation of Structural Proteins R-HSA-9694635 9.813198e-01 0.008 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.817801e-01 0.008 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.817801e-01 0.008 0 0
Elastic fibre formation R-HSA-1566948 9.821210e-01 0.008 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 9.821210e-01 0.008 0 0
Peroxisomal protein import R-HSA-9033241 9.825519e-01 0.008 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.825519e-01 0.008 0 0
Interleukin-10 signaling R-HSA-6783783 9.825695e-01 0.008 0 0
ABC transporter disorders R-HSA-5619084 9.825695e-01 0.008 0 0
Cholesterol biosynthesis R-HSA-191273 9.825695e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.829414e-01 0.007 0 0
Diseases associated with N-glycosylation of proteins R-HSA-3781860 9.836526e-01 0.007 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.837391e-01 0.007 0 0
Metabolism of polyamines R-HSA-351202 9.838435e-01 0.007 0 0
SLC transporter disorders R-HSA-5619102 9.839478e-01 0.007 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.840686e-01 0.007 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.840686e-01 0.007 0 0
MAP kinase activation R-HSA-450294 9.850419e-01 0.007 0 0
Glycogen metabolism R-HSA-8982491 9.850530e-01 0.007 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.859425e-01 0.006 0 0
Potassium Channels R-HSA-1296071 9.859425e-01 0.006 0 0
Maturation of spike protein R-HSA-9694548 9.863335e-01 0.006 0 0
Platelet degranulation R-HSA-114608 9.870858e-01 0.006 0 0
Intra-Golgi traffic R-HSA-6811438 9.875044e-01 0.005 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.875044e-01 0.005 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.877081e-01 0.005 0 0
Interferon gamma signaling R-HSA-877300 9.890941e-01 0.005 0 0
Ion channel transport R-HSA-983712 9.891517e-01 0.005 0 0
Pyrimidine catabolism R-HSA-73621 9.895540e-01 0.005 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 9.896166e-01 0.005 0 0
Cilium Assembly R-HSA-5617833 9.896823e-01 0.005 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.900552e-01 0.004 0 0
Toll-like Receptor Cascades R-HSA-168898 9.901886e-01 0.004 0 0
G1 Phase R-HSA-69236 9.904491e-01 0.004 0 0
Cyclin D associated events in G1 R-HSA-69231 9.904491e-01 0.004 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.906108e-01 0.004 0 0
Kidney development R-HSA-9830369 9.906108e-01 0.004 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.907367e-01 0.004 0 0
Mitochondrial biogenesis R-HSA-1592230 9.908285e-01 0.004 0 0
Parasitic Infection Pathways R-HSA-9824443 9.911217e-01 0.004 0 0
Leishmania infection R-HSA-9658195 9.911217e-01 0.004 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.912676e-01 0.004 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 9.914354e-01 0.004 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.917119e-01 0.004 0 0
Cytokine Signaling in Immune system R-HSA-1280215 9.920178e-01 0.003 0 0
Interleukin-17 signaling R-HSA-448424 9.925756e-01 0.003 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.925756e-01 0.003 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 9.925756e-01 0.003 0 0
Neuronal System R-HSA-112316 9.930446e-01 0.003 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.931363e-01 0.003 0 0
ECM proteoglycans R-HSA-3000178 9.931363e-01 0.003 0 0
Metal ion assimilation from the host R-HSA-9638482 9.931363e-01 0.003 0 0
Intraflagellar transport R-HSA-5620924 9.933259e-01 0.003 0 0
Co-stimulation by CD28 R-HSA-389356 9.933259e-01 0.003 0 0
Metal ion SLC transporters R-HSA-425410 9.933259e-01 0.003 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 9.936555e-01 0.003 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.938980e-01 0.003 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.943913e-01 0.002 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.943913e-01 0.002 0 0
Azathioprine ADME R-HSA-9748787 9.944211e-01 0.002 0 0
PPARA activates gene expression R-HSA-1989781 9.944567e-01 0.002 0 0
Parasite infection R-HSA-9664407 9.947030e-01 0.002 0 0
Leishmania phagocytosis R-HSA-9664417 9.947030e-01 0.002 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.947030e-01 0.002 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.947826e-01 0.002 0 0
TCR signaling R-HSA-202403 9.947973e-01 0.002 0 0
Signaling by VEGF R-HSA-194138 9.948011e-01 0.002 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.948993e-01 0.002 0 0
Iron uptake and transport R-HSA-917937 9.949928e-01 0.002 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.950662e-01 0.002 0 0
Mitochondrial protein degradation R-HSA-9837999 9.951474e-01 0.002 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.954845e-01 0.002 0 0
Nucleotide biosynthesis R-HSA-8956320 9.957364e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.963540e-01 0.002 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.964363e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.968975e-01 0.001 0 0
Dectin-2 family R-HSA-5621480 9.970213e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.974042e-01 0.001 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 9.976591e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.979191e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.982608e-01 0.001 0 0
Platelet homeostasis R-HSA-418346 9.982670e-01 0.001 0 0
Formation of the cornified envelope R-HSA-6809371 9.982711e-01 0.001 0 0
Post-translational protein modification R-HSA-597592 9.985857e-01 0.001 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.986065e-01 0.001 0 0
Downstream TCR signaling R-HSA-202424 9.986065e-01 0.001 0 0
Metabolism of steroid hormones R-HSA-196071 9.987852e-01 0.001 0 0
Nucleotide catabolism R-HSA-8956319 9.988669e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.988894e-01 0.000 0 0
COPII-mediated vesicle transport R-HSA-204005 9.990719e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.990842e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.991515e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.991814e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.992096e-01 0.000 0 0
Interferon alpha/beta signaling R-HSA-909733 9.992415e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.992714e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.992909e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.992909e-01 0.000 0 0
Organelle biogenesis and maintenance R-HSA-1852241 9.993190e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.993809e-01 0.000 0 0
Platelet activation, signaling and aggregation R-HSA-76002 9.993836e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.994075e-01 0.000 0 0
FOXO-mediated transcription R-HSA-9614085 9.994294e-01 0.000 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.995266e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.995885e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.996994e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.997230e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.997359e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.997684e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.998192e-01 0.000 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.998216e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.998450e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.998450e-01 0.000 0 0
Adaptive Immune System R-HSA-1280218 9.998824e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998913e-01 0.000 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.999179e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999273e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.999314e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999476e-01 0.000 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.999559e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999610e-01 0.000 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.999737e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999761e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999822e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999844e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999864e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999875e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999886e-01 0.000 0 0
Metabolism of proteins R-HSA-392499 9.999889e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999905e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999921e-01 0.000 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.999924e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.999925e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999941e-01 0.000 0 0
Hemostasis R-HSA-109582 9.999945e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999949e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999961e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999961e-01 0.000 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 9.999966e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999967e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999975e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999975e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999978e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999981e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999981e-01 0.000 0 0
Disease R-HSA-1643685 9.999986e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999989e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999990e-01 0.000 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.999993e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.999995e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999996e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999999e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999999e-01 0.000 0 0
Immune System R-HSA-168256 9.999999e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 1.000000e+00 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Innate Immune System R-HSA-168249 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways