TGFBR1

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Y Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Log-Odds: Y Sites / Y Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A0MZ66 S473 Sugiyama SHTN1 KIAA1598 LGtLNKSTSSRsLKsLDPENsEtELERILRRRKVtAEADss
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0 Y940 Sugiyama POTEF A26C1B ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA
O00170 T48 Sugiyama AIP XAP2 FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF
O00505 S60 Sugiyama KPNA3 QIP2 KRDEHLLKKRNVPQEEsLEDsDVDADFKAQNVTLEAILQNA
O00592 T556 Sugiyama PODXL PCLP PCLP1 DsWIVPLDNLTKDDLDEEEDtHL__________________
O15067 S530 Sugiyama PFAS KIAA0361 PICsLHDQGAGGNGNVLKELsDPAGAIIytsRFQLGDPTLN
O15427 S464 Sugiyama SLC16A3 MCT3 MCT4 EHFLKAEPEKNGEVVHtPEtsV___________________
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43615 S193 Sugiyama TIMM44 MIMT44 TIM44 TAAFRALsQGVEsVKKEIDDsVLGQtGPyRRPQRLRKRTEF
O43852 T196 Sugiyama CALU FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O60231 S107 Sugiyama DHX16 DBP2 DDX16 KIAA0577 PRP2 ARALLEKNRSYRLLEDsEEssEEtVsRAGsSLQKKRKKRKH
O60343 S304 Sugiyama TBC1D4 AS160 KIAA0603 ASQPALTSSRVCFPERILEDsGFDEQQEFRsRCssVTGVQR
O60361 Y136 Sugiyama NME2P1 SLRFKPEELVDYKSCAHDWVyE___________________
O60927 S74 Sugiyama PPP1R11 HCGV TCTE5 GRRssKCCCIyEKPRAFGEsstEsDEEEEEGCGHtHCVRGH
O75821 S189 Sugiyama EIF3G EIF3S4 CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O75822 S127 Sugiyama EIF3J EIF3S1 PRO0391 VLtPEEQLADKLRLKKLQEEsDLELAKEtFGVNNAVyGIDA
O95218 S188 Sugiyama ZRANB2 ZIS ZNF265 KLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRRSRSKSRS
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
P00558 S399 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P04075 S17 Sugiyama ALDOA ALDA ____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst
P04075 S354 Sugiyama ALDOA ALDA ANsLACQGKytPsGQAGAAAsEsLFVsNHAy__________
P04075 S356 Sugiyama ALDOA ALDA sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S39 Sugiyama ALDOA ALDA IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075 T123 Sugiyama ALDOA ALDA GVVGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYKKDGA
P04075 T124 Sugiyama ALDOA ALDA VVGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYKKDGAD
P04075 T125 Sugiyama ALDOA ALDA VGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYKKDGADF
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 S189 Sugiyama ANXA1 ANX1 LPC1 tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA
P04083 T172 Sugiyama ANXA1 ANX1 LPC1 INRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDF
P04406 S210 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406 T246 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05198 T284 Sugiyama EIF2S1 EIF2A EKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVDGDD
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05388 S304 Sugiyama RPLP0 AttAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
P05388 S307 Sugiyama RPLP0 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
P05787 S477 Sugiyama KRT8 CYK8 SSRAVVVKKIETRDGKLVsEssDVLPK______________
P06733 T100 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 KKLNVtEQEKIDKLMIEMDGtENKsKFGANAILGVsLAVCK
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 Y44 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 LFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKGVSK
P07195 T18 Sugiyama LDHB ___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI
P07205 S399 Sugiyama PGK2 PGKB CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07237 S88 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P07237 T335 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB VRLITLEEEMTKyKPEsEELtAERItEFCHRFLEGKIKPHL
P07237 T85 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB KAAGKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFF
P07355 Y188 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D RKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVKRKGT
P07437 T55 Sugiyama TUBB TUBB5 OK/SW-cl.56 tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07737 S85 Sugiyama PFN1 tLGGQKCsVIRDsLLQDGEFsMDLRtKstGGAPTFNVtVtK
P07900 S164 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA VAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGT
P07900 S165 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGEPMGRGTK
P07900 S231 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA SQFIGyPITLFVEKERDKEVsDDEAEEKEDKEEEKEKEEKE
P07900 S263 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK
P07900 S391 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MDNCEELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P07900 S52 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900 T305 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P07900 Y309 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA ELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHF
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195 T599 Sugiyama SLC3A2 MDU1 QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238 S159 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB VAEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGT
P08238 S160 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB AEKVVVITKHNDDEQyAWEssAGGsFtVRADHGEPIGRGTK
P08238 S383 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MDSCDELIPEYLNFIRGVVDsEDLPLNIsREMLQQsKILKV
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 T297 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IDQEELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLA
P08238 T467 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB NRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyIt
P08238 Y301 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB ELNKtKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHF
P08238 Y305 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tKPIWtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEG
P08670 S299 Sugiyama VIM VAAKNLQEAEEWyKSKFADLsEAANRNNDALRQAKQESTEY
P08708 S89 Sugiyama RPS17 RPS17L ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P08758 T10 Sugiyama ANXA5 ANX5 ENX2 PP4 ___________MAQVLRGtVtDFPGFDERADAEtLRKAMKG
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09972 S17 Sugiyama ALDOC ALDC ____MPHSYPALSAEQKKELsDIALRIVAPGKGILAADEsV
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10809 S67 Sugiyama HSPD1 HSP60 LADAVAVTMGPKGRtVIIEQsWGsPKVTKDGVtVAKsIDLK
P10809 T105 Sugiyama HSPD1 HSP60 DLKDKYKNIGAKLVQDVANNtNEEAGDGtttAtVLARSIAK
P11142 S40 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T45 Sugiyama HSPA8 HSC70 HSP73 HSPA10 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtN
P12004 S261 Sugiyama PCNA IADMGHLKyyLAPKIEDEEGs____________________
P12956 S560 Sugiyama XRCC6 G22P1 VtKRKHDNEGSGSKRPKVEysEEELKTHISKGTLGKFTVPM
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13639 S584 Sugiyama EEF2 EF2 DHACIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyM
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S306 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 TETVEEPMEEEEAAKEEKEEsDDEAAVEEEEEEKKPKTKKV
P15311 S539 Sugiyama EZR VIL2 TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P17066 S42 Sugiyama HSPA6 HSP70B' VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17066 T47 Sugiyama HSPA6 HSP70B' RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P17096 S103 Sugiyama HMGA1 HMGIY PRGRPKKLEKEEEEGIsQEssEEEQ________________
P17813 S646 EPSD|PSP ENG END VVAVAAPAssESSStNHSIGsTQstPCStSSMA________
P17813 S649 EPSD|PSP ENG END VAAPAssESSStNHSIGsTQstPCStSSMA___________
P17987 S551 Sugiyama TCP1 CCT1 CCTA IKLHPESKDDKHGsyEDAVHsGALND_______________
P18206 S726 Sugiyama VCL VEKMTGLVDEAIDtKsLLDAsEEAIKKDLDKCKVAMANIQP
P18669 T146 Sugiyama PGAM1 PGAMA CDABP0006 MEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIARALPF
P19338 T583 Sugiyama NCL sPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARIVTD
P20042 T49 Sugiyama EIF2S2 EIF2B GDtQtEEtQPsETKEVEPEPtEDKDLEADEEDTRKKDAsDD
P20810 S373 Sugiyama CAST LPEPEEKPKPRsEsELIDELsEDFDRsECKEKPSKPTEKTE
P22314 S46 Sugiyama UBA1 A1S9T UBE1 AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22392 Y151 Sugiyama NME2 NM23B SLWFKPEELVDyKSCAHDWVyE___________________
P23528 Y140 Sugiyama CFL1 CFL SKDAIKKKLtGIKHELQANCyEEVKDRCTLAEKLGGsAVIs
P25705 S52 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM AARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETG
P25705 S53 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM ARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETGR
P25788 S250 Sugiyama PSMA3 HC8 PSC8 KDIREEAEKyAKEsLKEEDEsDDDNM_______________
P25788 Y239 Sugiyama PSMA3 HC8 PSC8 ELTNGRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM____
P26639 S522 Sugiyama TARS1 TARS PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP
P27348 S145 Sugiyama YWHAQ YFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHP
P27348 S37 Sugiyama YWHAQ ERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKNVVGGRRS
P27816 S1151 Sugiyama MAP4 LSGGGDQREAQtLDsQIQEtsI___________________
P27816 S643 Sugiyama MAP4 IsPEtVTGtGKKCsLPAEEDsVLEKLGERKPCNsQPSELSS
P29692 S44 Sugiyama EEF1D EF1D RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P31946 S39 Sugiyama YWHAB ERyDDMAAAMKAVtEQGHELsNEERNLLsVAyKNVVGARRS
P31947 S37 Sugiyama SFN HME1 ERyEDMAAFMKGAVEKGEELsCEERNLLsVAyKNVVGGQRA
P34931 S42 Sugiyama HSPA1L VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931 T47 Sugiyama HSPA1L KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQN
P34932 S31 Sugiyama HSPA4 APG2 HSPH2 QSCYVAVARAGGIETIANEysDRCtPACIsFGPKNRSIGAA
P34932 S414 Sugiyama HSPA4 APG2 HSPH2 ITDVVPYPISLRWNsPAEEGssDCEVFSKNHAAPFSKVLTF
P35579 S1943 Sugiyama MYH9 RGDLPFVVPRRMARKGAGDGsDEEVDGKADGAEAKPAE___
P35579 T1906 Sugiyama MYH9 AQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRGDL
P35580 T1911 Sugiyama MYH10 EEATRANASRRKLQRELDDAtEANEGLSREVSTLKNRLRRG
P35659 S231 Sugiyama DEK SGMARKAKRTKCPEILsDEsssDEDEKKNKEEssDDEDKEs
P35659 S306 Sugiyama DEK DSSTTKKNQNSSKKEsEsEDssDDEPLIKKLKKPPTDEELK
P36871 S477 Sugiyama PGM1 KQFSANDKVYtVEKADNFEysDPVDGsIsRNQGLRLIFTDG
P36897 S360 Sugiyama TGFBR1 ALK5 SKR4 LVKKNGTCCIADLGLAVRHDsATDtIDIAPNHRVGTKRYMA
P36897 S387 Sugiyama TGFBR1 ALK5 SKR4 IAPNHRVGTKRYMAPEVLDDsINMKHFESFKRADIYAMGLV
P36897 T364 Sugiyama TGFBR1 ALK5 SKR4 NGTCCIADLGLAVRHDsATDtIDIAPNHRVGTKRYMAPEVL
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P39019 Y48 Sugiyama RPS19 LKVPEWVDtVKLAKHKELAPyDENWFytRAAstARHLYLRG
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P41091 T21 Sugiyama EIF2S3 EIF2G MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
P41227 S213 Sugiyama NAA10 ARD1 ARD1A TE2 ACREEKGLAAEDsGGDsKDLsEVsEtTEstDVKDssEAsDs
P41227 S216 Sugiyama NAA10 ARD1 ARD1A TE2 EEKGLAAEDsGGDsKDLsEVsEtTEstDVKDssEAsDsAs_
P41236 S122 Sugiyama PPP1R2 IPP2 RKLAAAEGLEPKyRIQEQEssGEEDsDLsPEEREKKRQFEM
P43121 T298 Sugiyama MCAM MUC18 PPPHFSISKQNPstREAEEEttNDNGVLVLEPARKEHSGRY
P48741 S42 Sugiyama HSPA7 HSP70B VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P48741 T47 Sugiyama HSPA7 HSP70B RVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHN
P49321 S432 Sugiyama NASP EKVRAKLVPsQEEtKLsVEEsEAAGDGVDTKVAQGAtEKsP
P49327 S2198 Sugiyama FASN FAS EVRQLTLRKLQELSSKADEAsELACPtPKEDGLAQQQtQLN
P49588 T481 Sugiyama AARS1 AARS DLIMLDIYAIEELRARGLEVtDDsPKYNYHLDSSGSYVFEN
P50502 S75 Sugiyama ST13 AAG2 FAM10A1 HIP SNC6 TKEEKPDSKKVEEDLKADEPssEEsDLEIDKEGVIEPDTDA
P52907 S106 Sugiyama CAPZA1 RFLDPRNKISFKFDHLRKEAsDPQPEEADGGLKsWREsCDs
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54578 S492 Sugiyama USP14 TGT WHIAYVLLYGPRRVEIMEEEsEQ__________________
P54652 S41 Sugiyama HSPA2 VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T46 Sugiyama HSPA2 KVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTN
P55060 S366 Sugiyama CSE1L CAS XPO2 KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P57721 S82 Sugiyama PCBP3 PCBP3-OT1 PCBP3OT GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK
P60228 S442 Sugiyama EIF3E EIF3S6 INT6 IEKKLNQNSRSEAPNWAtQDsGFy_________________
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 Y240 Sugiyama ACTB ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P60709 Y53 Sugiyama ACTB sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61247 S237 Sugiyama RPS3A FTE1 MFTL MLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyE
P61604 S21 Sugiyama HSPE1 MAGQAFRKFLPLFDRVLVERsAAETVTKGGIMLPEKSQGKV
P61916 S29 Sugiyama NPC2 HE1 LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62273 Y7 Sugiyama RPS29 ______________MGHQQLyWsHPRKFGQGSRSCRVCSNR
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 Y242 Sugiyama ACTA2 ACTSA ACTVS GIG46 ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P62736 Y55 Sugiyama ACTA2 ACTSA ACTVS GIG46 sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P63104 S37 Sugiyama YWHAZ ERyDDMAACMKsVtEQGAELsNEERNLLsVAyKNVVGARRs
P63104 T30 Sugiyama YWHAZ AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63167 S14 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 _______MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNI
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 Y240 Sugiyama ACTG1 ACTG ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
P63261 Y53 Sugiyama ACTG1 ACTG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 Y241 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P63267 Y54 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 Y242 Sugiyama ACTC1 ACTC ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68032 Y55 Sugiyama ACTC1 ACTC sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68104 S300 SIGNOR|EPSD|PSP EEF1A1 EEF1A EF1A LENG7 FAPVNVttEVKsVEMHHEALsEALPGDNVGFNVKNVSVKDV
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 Y242 Sugiyama ACTA1 ACTA ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET
P68133 Y55 Sugiyama ACTA1 ACTA sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P84022 S423 SIGNOR SMAD3 MADH3 PLQWLDKVLTQMGsPsIRCssVs__________________
P84022 S425 SIGNOR SMAD3 MADH3 QWLDKVLTQMGsPsIRCssVs____________________
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 T126 Sugiyama SET SALLGEEDEEALHYLTRVEVtEFEDIKsGyRIDFyFDENPy
Q03167 S831 EPSD|PSP TGFBR3 HTGETAGRQQVPTSPPASENsSAAHSIGSTQStPCSSSSTA
Q04637 S1430 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI GQDIGAFVAEQKVEyTLGEEsEAPGQRALPsEELNRQLEKL
Q04917 S150 Sugiyama YWHAH YWHA1 YYRYLAEVASGEKKNsVVEAsEAAyKEAFEISKEQMQPTHP
Q06830 Y116 Sugiyama PRDX1 PAGA PAGB TDPX2 GLGPMNIPLVSDPKRtIAQDyGVLKADEGIsFRGLFIIDDK
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q07157 S1064 Sugiyama TJP1 ZO1 PYVEKQAsRDLEQPtyRyEsssytDQFsRNYEHRLRYEDRV
Q08J23 T733 Sugiyama NSUN2 SAKI TRM4 EGVILtNEsAAstGQPDNDVtEGQRAGEPNsPDAEEANsPD
Q12792 T348 Sugiyama TWF1 PTK9 GPAGKRGIRRLIRGPAEtEAttD__________________
Q12906 T300 Sugiyama ILF3 DRBF MPHOSPH4 NF90 ASGIVMPDGSGIYDPCEKEAtDAIGHLDRQQREDItQsAQH
Q13263 S479 Sugiyama TRIM28 KAP1 RNF96 TIF1B ssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERLDLDLtA
Q13428 S346 Sugiyama TCOF1 VAsQTKAGKPEEDSEsSSEEssDsEEETPAAKALLQAKASG
Q13428 S765 Sugiyama TCOF1 GKTGPTVTQVKAEKQEDsEssEEEsDSEEAAAsPAQVKTSV
Q13428 S88 Sugiyama TCOF1 DAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRLAst
Q13442 S63 Sugiyama PDAP1 HASPP28 GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI
Q13501 S276 Sugiyama SQSTM1 ORCA OSIL DIDVEHGGKRsRLtPVsPEssstEEKsssQPssCCsDPsKP
Q13541 S112 Sugiyama EIF4EBP1 EAsQsHLRNsPEDKRAGGEEsQFEMDI______________
Q13547 S421 Sugiyama HDAC1 RPD3L1 PDKRIsICssDKRIACEEEFsDsEEEGEGGRKNsSNFKKAK
Q13765 S132 Sugiyama NACA HSD48 YKSPAsDtyIVFGEAKIEDLsQQAQLAAAEKFKVQGEAVsN
Q14152 S1188 Sugiyama EIF3A EIF3S10 KIAA0139 PWRPLVKPGGWREKEKAREEsWGPPRESRPsEEREWDREKE
Q14568 S164 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 VAEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGT
Q14568 S165 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 AEKVTVITKHNDDEQyAWEssAGGsFtVRTDTGERMGRGTK
Q14568 S52 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS
Q14677 S166 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 REERKKAKKNKDKyVGVssDsVGGFRysERYDPEPKSKWDE
Q15084 S169 Sugiyama PDIA6 ERP5 P5 TXNDC7 GKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFYAPW
Q15084 T166 Sugiyama PDIA6 ERP5 P5 TXNDC7 YSSGKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFY
Q15185 S113 Sugiyama PTGES3 P23 TEBP RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD
Q15365 S50 Sugiyama PCBP1 GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK
Q15366 S50 Sugiyama PCBP2 GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK
Q15796 S464 GPS6|ELM|iPTMNet|EPSD|PSP SMAD2 MADH2 MADR2 GPLQWLDKVLTQMGsPsVRCssMs_________________
Q15796 S465 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SMAD2 MADH2 MADR2 PLQWLDKVLTQMGsPsVRCssMs__________________
Q15796 S467 GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP SMAD2 MADH2 MADR2 QWLDKVLTQMGsPsVRCssMs____________________
Q15797 S462 iPTMNet|EPSD SMAD1 BSP1 MADH1 MADR1 GPLQWLDKVLTQMGsPHNPIssVs_________________
Q15797 S463 iPTMNet|EPSD SMAD1 BSP1 MADH1 MADR1 PLQWLDKVLTQMGsPHNPIssVs__________________
Q15797 S465 iPTMNet|EPSD SMAD1 BSP1 MADH1 MADR1 QWLDKVLTQMGsPHNPIssVs____________________
Q16513 S591 Sugiyama PKN2 PRK2 PRKCL2 EPEPPPAPPRAssLGEIDEssELRVLDIPGQDsEtVFDIQN
Q16576 T10 Sugiyama RBBP7 RBAP46 ___________MAsKEMFEDtVEERVINEEYKIWKKNTPFL
Q16626 S163 Sugiyama MEA1 MEA RTMAGVSLPAPGVPAWAREIsDAQWEDVVQKALQARQAsPA
Q16658 Y493 Sugiyama FSCN1 FAN1 HSN SNL DHAGVLKASAEtVDPAsLWEy____________________
Q2VIR3 T21 Sugiyama EIF2S3B MAGGEAGVtLGQPHLsRQDLttLDVtKLTPLSHEVISRQAt
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q562R1 T107 Sugiyama ACTBL2 WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q562R1 Y241 Sugiyama ACTBL2 ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3 Y940 Sugiyama POTEE A26C1A POTE2 ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA
Q6UXH1 S295 Sugiyama CRELD2 UNQ185/PRO211 KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q8NE71 S595 Sugiyama ABCF1 ABC50 TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP
Q8NHW5 S304 Sugiyama RPLP0P6 DTTAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______
Q8NHW5 S307 Sugiyama RPLP0P6 AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________
Q8WUM4 T464 Sugiyama PDCD6IP AIP1 ALIX KIAA1375 LQRNREILDEsLRLLDEEEAtDNDLRAKFKERWQRtPSNEL
Q92769 S422 Sugiyama HDAC2 PDKRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGA
Q96FW1 S18 EPSD|PSP OTUB1 OTB1 OTU1 HSPC263 ___MAAEEPQQQKQEPLGsDsEGVNCLAyDEAIMAQQDRIQ
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96HE7 T148 Sugiyama ERO1A ERO1L UNQ434/PRO865 IEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNFCEA
Q96SB4 S334 Sugiyama SRPK1 ERPLKENPPNKMtQEKLEEsstIGQDQtLMERDTEGGAAEI
Q99497 S57 Sugiyama PARK7 GLAGKDPVQCsRDVVICPDAsLEDAKKEGPyDVVVLPGGNL
Q99832 T351 Sugiyama CCT7 CCTH NIP7-1 QtSVNALSADVLGRCQVFEEtQIGGERyNFFtGCPKAKTCt
Q9BQE3 S439 Sugiyama TUBA1C TUBA6 SEAREDMAALEKDyEEVGADsADGEDEGEEy__________
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7 Y240 Sugiyama POTEKP ACTBL3 FKSG30 ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA
Q9C0C2 T1323 Sugiyama TNKS1BP1 KIAA1741 TAB182 ELGVGQMDWGNNLGLRDLEVtCDPDsGGsQGLRGCGVGQMD
Q9H3D4 S160 SIGNOR TP63 KET P63 P73H P73L TP73L QNSVTAPSPyAQPSSTFDALsPsPAIPSNTDyPGPHSFDVS
Q9H3D4 S68 SIGNOR TP63 KET P63 P73H P73L TP73L EFLsPEVFQHIWDFLEQPICsVQPIDLNFVDEPSEDGATNK
Q9HCC0 S256 Sugiyama MCCC2 MCCB QGTIFLAGPPLVKAATGEEVsAEDLGGADLHCRKSGVSDHW
Q9HCN8 S75 Sugiyama SDF2L1 UNQ1941/PRO4424 SHDIKYGSGSGQQSVtGVEAsDDANSyWRIRGGSEGGCPRG
Q9NPQ8 T441 Sugiyama RIC8A AARGLMAGGRPEGQysEDEDtDtDEyKEAKAsINPVTGRVE
Q9NR28 S230 Sugiyama DIABLO SMAC EAQIEELRQKTQEEGEERAEsEQEAyLRED___________
Q9NRX4 T119 Sugiyama PHPT1 PHP14 CGI-202 HSPC141 PAQHAISTEKIKAKyPDyEVtWANDGy______________
Q9NWX6 S298 Sugiyama THG1L ICF45 HCDIIGDAFWKEHPEILDEDs____________________
Q9NZ53 S596 Sugiyama PODXL2 UNQ1861/PRO3742 ALNGPGsWGALMGGKRDPEDsDVFEEDtHL___________
Q9UHI6 S677 Sugiyama DDX20 DP103 GEMIN3 DSySSRTSSQSKGNKsyLEGssDNQLKDsEstPVDDRIsLE
Q9UI30 T123 Sugiyama TRMT112 AD-001 HSPC152 HSPC170 SGRMFPISRGIPNMLLsEEEtEs__________________
Q9UNF1 S52 Sugiyama MAGED2 BCG1 TVTQNVEVPEtPKASKALEVsEDVKVSKASGVSKAtEVsKt
Q9UNZ2 S165 Sugiyama NSFL1C UBXN2C SKPRPFAGGGYRLGAAPEEEsAyVAGEKRQHssQDVHVVLK
Q9UQ80 S383 Sugiyama PA2G4 EBP1 sRKtQKKKKKKAsKtAENAtsGEtLEENEAGD_________
Q9UQ80 T386 Sugiyama PA2G4 EBP1 tQKKKKKKAsKtAENAtsGEtLEENEAGD____________
Q9Y2B0 S116 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 IDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKFA
Q9Y2B0 S65 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y5X1 S116 Sugiyama SNX9 SH3PX1 SH3PXD3A SNNHQVGSGNDPWSAWSASKsGNWESsEGWGAQPEGAGAQR
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
MITF-M-dependent gene expression R-HSA-9856651 1.262205e-07 6.899 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 5.055995e-07 6.296 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.875925e-06 5.541 0 0
Cell Cycle R-HSA-1640170 1.922516e-06 5.716 0 0
Metabolism of RNA R-HSA-8953854 7.093542e-06 5.149 0 0
Cell Cycle Checkpoints R-HSA-69620 8.536033e-06 5.069 0 0
DNA Repair R-HSA-73894 2.419687e-05 4.616 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 3.371848e-05 4.472 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.995031e-05 4.398 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 3.995031e-05 4.398 0 0
G0 and Early G1 R-HSA-1538133 6.414647e-05 4.193 0 0
G2/M Checkpoints R-HSA-69481 6.091750e-05 4.215 0 0
Apoptotic execution phase R-HSA-75153 6.187529e-05 4.208 0 0
Chromatin modifying enzymes R-HSA-3247509 4.829156e-05 4.316 0 0
Chromatin organization R-HSA-4839726 5.887986e-05 4.230 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 6.414647e-05 4.193 0 0
Regulation of TP53 Activity R-HSA-5633007 7.768380e-05 4.110 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.897811e-04 3.722 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.003532e-04 3.522 0 0
Disorders of Nervous System Development R-HSA-9697154 3.003532e-04 3.522 0 0
Pervasive developmental disorders R-HSA-9005895 3.003532e-04 3.522 0 0
mRNA Splicing R-HSA-72172 4.021714e-04 3.396 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 3.811601e-04 3.419 0 0
Cell Cycle, Mitotic R-HSA-69278 3.862883e-04 3.413 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.132861e-04 3.384 0 0
mRNA Splicing - Major Pathway R-HSA-72163 4.397770e-04 3.357 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 6.685978e-04 3.175 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.092412e-03 2.962 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.092412e-03 2.962 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.112675e-03 2.954 0 0
Disorders of Developmental Biology R-HSA-9675151 1.220450e-03 2.913 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.449518e-03 2.839 1 0
DNA Double-Strand Break Repair R-HSA-5693532 1.632223e-03 2.787 0 0
Signaling by Hippo R-HSA-2028269 1.541226e-03 2.812 0 0
Epigenetic regulation of gene expression R-HSA-212165 1.758757e-03 2.755 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.676050e-03 2.776 0 0
Deubiquitination R-HSA-5688426 1.732882e-03 2.761 1 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 1.657429e-03 2.781 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.657429e-03 2.781 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.778993e-03 2.750 0 0
Gene expression (Transcription) R-HSA-74160 1.951707e-03 2.710 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.922410e-03 2.716 0 0
mRNA 3'-end processing R-HSA-72187 2.133257e-03 2.671 0 0
Signaling by LTK R-HSA-9842663 2.106538e-03 2.676 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.370929e-03 2.625 0 0
G2/M DNA damage checkpoint R-HSA-69473 2.361954e-03 2.627 0 0
G1/S Transition R-HSA-69206 2.416234e-03 2.617 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.893921e-03 2.539 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.893921e-03 2.539 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.893921e-03 2.539 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.893921e-03 2.539 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.813223e-03 2.551 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.007257e-03 2.522 0 0
Signaling by ALK in cancer R-HSA-9700206 3.007257e-03 2.522 0 0
G1/S-Specific Transcription R-HSA-69205 2.998118e-03 2.523 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.357265e-03 2.474 0 0
Activation of the pre-replicative complex R-HSA-68962 4.229161e-03 2.374 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 4.197203e-03 2.377 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.229161e-03 2.374 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 4.192675e-03 2.378 0 0
Signaling by ALK R-HSA-201556 4.466602e-03 2.350 0 0
Unwinding of DNA R-HSA-176974 4.657306e-03 2.332 0 0
Notch-HLH transcription pathway R-HSA-350054 4.983378e-03 2.302 0 0
Signaling by ERBB2 R-HSA-1227986 5.083202e-03 2.294 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.382072e-03 2.269 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 5.607740e-03 2.251 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 5.610530e-03 2.251 0 0
PKMTs methylate histone lysines R-HSA-3214841 5.716624e-03 2.243 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 6.042937e-03 2.219 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 6.146426e-03 2.211 0 0
Nucleotide Excision Repair R-HSA-5696398 6.300869e-03 2.201 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.357945e-03 2.197 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.782948e-03 2.169 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 7.934258e-03 2.100 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 7.934258e-03 2.100 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 8.011122e-03 2.096 0 0
HDACs deacetylate histones R-HSA-3214815 9.112411e-03 2.040 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 1.020011e-02 1.991 0 0
Ephrin signaling R-HSA-3928664 9.481439e-03 2.023 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.062232e-02 1.974 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.966256e-03 2.001 0 0
RNA Polymerase III Transcription R-HSA-74158 1.062232e-02 1.974 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.481439e-03 2.023 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.062232e-02 1.974 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.074746e-02 1.969 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.117825e-02 1.952 0 0
Ub-specific processing proteases R-HSA-5689880 1.158599e-02 1.936 1 1
Processing of DNA double-strand break ends R-HSA-5693607 1.160090e-02 1.936 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.350859e-02 1.869 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.348389e-02 1.870 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.317383e-02 1.880 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.484152e-02 1.829 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.484152e-02 1.829 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.516311e-02 1.819 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.648086e-02 1.783 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 1.533960e-02 1.814 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 1.533960e-02 1.814 0 0
Homology Directed Repair R-HSA-5693538 1.642420e-02 1.785 0 0
RNA Polymerase II Transcription R-HSA-73857 1.553725e-02 1.809 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 2.088081e-02 1.680 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 2.088081e-02 1.680 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 2.088081e-02 1.680 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 2.088081e-02 1.680 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 2.088081e-02 1.680 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 2.088081e-02 1.680 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 2.088081e-02 1.680 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 2.088081e-02 1.680 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 2.088081e-02 1.680 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 2.088081e-02 1.680 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 2.088081e-02 1.680 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 1.773098e-02 1.751 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.948547e-02 1.710 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.123423e-02 1.673 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.828214e-02 1.738 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 2.123423e-02 1.673 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.035649e-02 1.691 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.944989e-02 1.711 0 0
Cellular response to heat stress R-HSA-3371556 1.944989e-02 1.711 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.773098e-02 1.751 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 2.074014e-02 1.683 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.828214e-02 1.738 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.215910e-02 1.654 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 2.215910e-02 1.654 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.322381e-02 1.634 0 0
Apoptosis R-HSA-109581 2.409166e-02 1.618 0 0
Resolution of D-Loop Structures R-HSA-5693537 2.466595e-02 1.608 0 0
EPH-Ephrin signaling R-HSA-2682334 2.796930e-02 1.553 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.735529e-02 1.563 0 0
Signaling by EGFR R-HSA-177929 2.714234e-02 1.566 0 0
GP1b-IX-V activation signalling R-HSA-430116 2.934461e-02 1.532 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.735529e-02 1.563 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.934461e-02 1.532 0 0
HDMs demethylate histones R-HSA-3214842 2.971059e-02 1.527 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.982957e-02 1.525 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 3.023163e-02 1.520 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 3.023163e-02 1.520 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 3.147891e-02 1.502 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 3.445534e-02 1.463 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.334124e-02 1.477 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 3.166171e-02 1.499 0 0
Signaling by EGFR in Cancer R-HSA-1643713 3.334124e-02 1.477 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.410333e-02 1.467 0 0
Myogenesis R-HSA-525793 3.334124e-02 1.477 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 3.147891e-02 1.502 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.440578e-02 1.463 0 0
Diseases of DNA repair R-HSA-9675135 3.166171e-02 1.499 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 3.147625e-02 1.502 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.527961e-02 1.452 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 3.585995e-02 1.445 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 3.656116e-02 1.437 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.723608e-02 1.429 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.723608e-02 1.429 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.723608e-02 1.429 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 3.779853e-02 1.423 0 0
Amplification of signal from the kinetochores R-HSA-141424 3.779853e-02 1.423 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 4.139852e-02 1.383 0 0
HIV elongation arrest and recovery R-HSA-167287 4.139852e-02 1.383 0 0
Formation of the Early Elongation Complex R-HSA-113418 4.139852e-02 1.383 0 0
Pausing and recovery of HIV elongation R-HSA-167290 4.139852e-02 1.383 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.368185e-02 1.360 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 4.002118e-02 1.398 0 0
Bicarbonate transporters R-HSA-425381 4.305392e-02 1.366 0 0
rRNA processing R-HSA-72312 4.245297e-02 1.372 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 4.002118e-02 1.398 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.848765e-02 1.415 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 4.374304e-02 1.359 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 4.374304e-02 1.359 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 4.374304e-02 1.359 0 0
Regulation of signaling by CBL R-HSA-912631 4.488774e-02 1.348 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 4.488774e-02 1.348 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 4.583111e-02 1.339 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 4.583111e-02 1.339 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.631462e-02 1.334 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 5.347738e-02 1.272 0 0
PDGFR mutants bind TKIs R-HSA-9674428 5.347738e-02 1.272 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 5.347738e-02 1.272 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 5.347738e-02 1.272 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 5.347738e-02 1.272 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 5.347738e-02 1.272 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.053553e-02 1.296 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.754543e-02 1.323 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 5.299960e-02 1.276 0 0
HIV Transcription Elongation R-HSA-167169 4.754543e-02 1.323 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.754543e-02 1.323 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 5.053553e-02 1.296 0 0
DAP12 signaling R-HSA-2424491 5.053553e-02 1.296 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 5.091030e-02 1.293 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 4.933438e-02 1.307 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 5.161375e-02 1.287 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 4.754543e-02 1.323 0 0
Smooth Muscle Contraction R-HSA-445355 5.416580e-02 1.266 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 5.551261e-02 1.256 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 5.551261e-02 1.256 0 0
Death Receptor Signaling R-HSA-73887 5.704426e-02 1.244 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 5.746512e-02 1.241 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.746512e-02 1.241 0 0
DNA Double Strand Break Response R-HSA-5693606 5.828890e-02 1.234 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.940869e-02 1.226 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 5.940869e-02 1.226 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 5.940869e-02 1.226 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 6.036956e-02 1.219 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 6.036956e-02 1.219 0 0
DNA strand elongation R-HSA-69190 6.076234e-02 1.216 0 0
M Phase R-HSA-68886 6.186817e-02 1.209 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.852519e-02 1.164 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 6.852519e-02 1.164 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.044622e-02 1.152 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.628391e-02 1.179 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 6.628391e-02 1.179 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 7.207573e-02 1.142 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 7.207573e-02 1.142 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 7.505763e-02 1.125 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.347905e-02 1.197 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 7.125526e-02 1.147 0 0
Integrin signaling R-HSA-354192 6.628391e-02 1.179 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 7.505763e-02 1.125 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 7.363515e-02 1.133 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 6.628391e-02 1.179 0 0
Signaling by FGFR4 R-HSA-5654743 6.505836e-02 1.187 0 0
Signaling by FGFR3 R-HSA-5654741 7.505763e-02 1.125 0 0
Nuclear Envelope Breakdown R-HSA-2980766 7.060948e-02 1.151 0 0
Mitotic Prophase R-HSA-68875 7.072769e-02 1.150 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 7.207573e-02 1.142 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 7.505763e-02 1.125 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 7.363515e-02 1.133 0 0
Dual incision in TC-NER R-HSA-6782135 7.513711e-02 1.124 0 0
Programmed Cell Death R-HSA-5357801 7.662365e-02 1.116 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 7.778780e-02 1.109 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 7.778780e-02 1.109 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 7.781943e-02 1.109 0 0
Nuclear import of Rev protein R-HSA-180746 7.813545e-02 1.107 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 7.813545e-02 1.107 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 7.823303e-02 1.107 0 0
NRIF signals cell death from the nucleus R-HSA-205043 7.823303e-02 1.107 0 0
S Phase R-HSA-69242 7.915783e-02 1.102 0 0
snRNP Assembly R-HSA-191859 7.983145e-02 1.098 0 0
Metabolism of non-coding RNA R-HSA-194441 7.983145e-02 1.098 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 8.036671e-02 1.095 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.036671e-02 1.095 0 0
Mitotic Prometaphase R-HSA-68877 8.207281e-02 1.086 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 8.214309e-02 1.085 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 8.214309e-02 1.085 0 0
Separation of Sister Chromatids R-HSA-2467813 8.240438e-02 1.084 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.040980e-01 0.983 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.040980e-01 0.983 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.040980e-01 0.983 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.040980e-01 0.983 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.040980e-01 0.983 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.040980e-01 0.983 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.040980e-01 0.983 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.040980e-01 0.983 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.040980e-01 0.983 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 9.930472e-02 1.003 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.588044e-02 1.066 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 8.549534e-02 1.068 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 8.660591e-02 1.062 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.002623e-01 0.999 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 8.850316e-02 1.053 0 0
SDK interactions R-HSA-373756 1.040980e-01 0.983 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 8.549534e-02 1.068 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 9.788784e-02 1.009 0 0
Viral Messenger RNA Synthesis R-HSA-168325 8.971810e-02 1.047 0 0
Membrane Trafficking R-HSA-199991 9.899617e-02 1.004 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 8.850316e-02 1.053 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 8.850316e-02 1.053 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 9.930472e-02 1.003 0 0
Generic Transcription Pathway R-HSA-212436 8.811649e-02 1.055 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.445999e-02 1.073 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 8.469203e-02 1.072 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 8.469203e-02 1.072 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 8.469203e-02 1.072 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 8.469203e-02 1.072 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 8.469203e-02 1.072 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 8.469203e-02 1.072 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.041451e-01 0.982 0 0
MECP2 regulates transcription factors R-HSA-9022707 1.055524e-01 0.977 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 1.055524e-01 0.977 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 1.055524e-01 0.977 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 1.055524e-01 0.977 0 0
Recycling of eIF2:GDP R-HSA-72731 1.055524e-01 0.977 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 1.055524e-01 0.977 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 1.055524e-01 0.977 0 0
G2/M Transition R-HSA-69275 1.061136e-01 0.974 0 0
HIV Life Cycle R-HSA-162587 1.080986e-01 0.966 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.082318e-01 0.966 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.082318e-01 0.966 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.107120e-01 0.956 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.123215e-01 0.950 0 0
Defective SLC17A5 causes Salla disease (SD) and ISSD R-HSA-5619035 1.520143e-01 0.818 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 1.520143e-01 0.818 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.520143e-01 0.818 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 1.520143e-01 0.818 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 1.520143e-01 0.818 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.973705e-01 0.705 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 1.973705e-01 0.705 1 1
Defective ABCB6 causes MCOPCB7 R-HSA-5683371 1.973705e-01 0.705 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.973705e-01 0.705 1 1
PLC-gamma1 signalling R-HSA-167021 2.403034e-01 0.619 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 2.403034e-01 0.619 0 0
Defective ABCD4 causes MAHCJ R-HSA-5683329 2.403034e-01 0.619 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 2.403034e-01 0.619 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 1.418144e-01 0.848 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 2.809423e-01 0.551 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 2.809423e-01 0.551 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 2.809423e-01 0.551 1 1
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 2.809423e-01 0.551 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.809423e-01 0.551 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.802250e-01 0.744 0 0
NrCAM interactions R-HSA-447038 3.194096e-01 0.496 0 0
IRS activation R-HSA-74713 3.194096e-01 0.496 0 0
G2 Phase R-HSA-68911 3.194096e-01 0.496 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 3.194096e-01 0.496 1 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 3.194096e-01 0.496 1 1
FLT3 signaling by CBL mutants R-HSA-9706377 3.194096e-01 0.496 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.999676e-01 0.699 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.199450e-01 0.658 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.558212e-01 0.449 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 3.558212e-01 0.449 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.558212e-01 0.449 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 3.558212e-01 0.449 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 3.558212e-01 0.449 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 3.902868e-01 0.409 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.902868e-01 0.409 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 3.902868e-01 0.409 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.902868e-01 0.409 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 3.902868e-01 0.409 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 3.902868e-01 0.409 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.902868e-01 0.409 0 0
Spry regulation of FGF signaling R-HSA-1295596 2.805114e-01 0.552 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 2.805114e-01 0.552 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 2.805114e-01 0.552 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 2.805114e-01 0.552 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 2.805114e-01 0.552 0 0
Phosphorylation of the APC/C R-HSA-176412 3.006908e-01 0.522 0 0
IFNG signaling activates MAPKs R-HSA-9732724 4.229104e-01 0.374 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 4.229104e-01 0.374 0 0
SOS-mediated signalling R-HSA-112412 4.229104e-01 0.374 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 4.229104e-01 0.374 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 3.207720e-01 0.494 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 1.442955e-01 0.841 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 2.729820e-01 0.564 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.877717e-01 0.541 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 3.604562e-01 0.443 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.301193e-01 0.886 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 3.175014e-01 0.498 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 3.799805e-01 0.420 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 3.799805e-01 0.420 0 0
Post-translational protein phosphorylation R-HSA-8957275 1.510795e-01 0.821 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 2.467994e-01 0.608 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.985408e-01 0.702 0 0
Translation initiation complex formation R-HSA-72649 2.569886e-01 0.590 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 3.992480e-01 0.399 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 4.182304e-01 0.379 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 4.182304e-01 0.379 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 4.182304e-01 0.379 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 3.332102e-01 0.477 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 2.885983e-01 0.540 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 3.455353e-01 0.462 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 4.369032e-01 0.360 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 4.369032e-01 0.360 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 4.369032e-01 0.360 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 4.369032e-01 0.360 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 3.198634e-01 0.495 0 0
Centrosome maturation R-HSA-380287 3.074268e-01 0.512 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.192369e-01 0.378 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.192369e-01 0.378 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.313733e-01 0.365 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 4.420867e-01 0.354 0 0
Transcription of the HIV genome R-HSA-167172 2.427694e-01 0.615 0 0
EGFR downregulation R-HSA-182971 3.323929e-01 0.478 0 0
Signaling by NOTCH2 R-HSA-1980145 3.916288e-01 0.407 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.132460e-01 0.384 0 0
Regulation of endogenous retroelements R-HSA-9842860 2.850539e-01 0.545 0 0
Downstream signal transduction R-HSA-186763 1.487623e-01 0.828 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 1.734223e-01 0.761 0 0
mRNA Capping R-HSA-72086 1.291494e-01 0.889 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 1.700130e-01 0.770 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 1.700130e-01 0.770 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 1.568614e-01 0.804 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 3.044359e-01 0.517 0 0
Generation of second messenger molecules R-HSA-202433 1.199012e-01 0.921 0 0
Fanconi Anemia Pathway R-HSA-6783310 1.700130e-01 0.770 0 0
Signal attenuation R-HSA-74749 1.608074e-01 0.794 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 4.271398e-01 0.369 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.608543e-01 0.584 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 2.792771e-01 0.554 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 2.292302e-01 0.640 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 2.986375e-01 0.525 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.377786e-01 0.359 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.377786e-01 0.359 0 0
IGF1R signaling cascade R-HSA-2428924 2.078279e-01 0.682 0 0
PI3K/AKT activation R-HSA-198203 1.608074e-01 0.794 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 1.802250e-01 0.744 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 3.194096e-01 0.496 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 1.223724e-01 0.912 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.601849e-01 0.585 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.472720e-01 0.459 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.421228e-01 0.616 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.910380e-01 0.719 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 2.729820e-01 0.564 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.412577e-01 0.467 0 0
EPHB-mediated forward signaling R-HSA-3928662 3.209062e-01 0.494 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 4.369032e-01 0.360 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.418144e-01 0.848 0 0
Regulation of gap junction activity R-HSA-191650 2.809423e-01 0.551 0 0
NF-kB is activated and signals survival R-HSA-209560 1.999676e-01 0.699 0 0
Formation of axial mesoderm R-HSA-9796292 2.400759e-01 0.620 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.729820e-01 0.564 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 2.163931e-01 0.665 0 0
Germ layer formation at gastrulation R-HSA-9754189 3.799805e-01 0.420 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.345716e-01 0.871 0 0
Repression of WNT target genes R-HSA-4641265 2.199450e-01 0.658 0 0
Rab regulation of trafficking R-HSA-9007101 2.968381e-01 0.527 0 0
Signalling to RAS R-HSA-167044 1.734223e-01 0.761 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 2.483019e-01 0.605 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.623131e-01 0.790 0 0
Molecules associated with elastic fibres R-HSA-2129379 3.323929e-01 0.478 0 0
Late Phase of HIV Life Cycle R-HSA-162599 1.763984e-01 0.754 0 0
Signaling by FGFR2 R-HSA-5654738 1.162707e-01 0.935 0 0
Activation of AKT2 R-HSA-165158 3.194096e-01 0.496 0 0
Aggrephagy R-HSA-9646399 1.199012e-01 0.921 0 0
PTK6 Expression R-HSA-8849473 4.229104e-01 0.374 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 3.207720e-01 0.494 0 0
MET promotes cell motility R-HSA-8875878 2.365413e-01 0.626 0 0
DARPP-32 events R-HSA-180024 3.026197e-01 0.519 0 0
Negative regulation of MET activity R-HSA-6807004 3.992480e-01 0.399 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 3.992480e-01 0.399 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 3.409644e-01 0.467 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.126414e-01 0.948 0 0
RNA Polymerase I Transcription R-HSA-73864 1.985408e-01 0.702 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 1.294153e-01 0.888 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 2.582769e-01 0.588 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.291494e-01 0.889 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.388161e-01 0.858 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 2.021511e-01 0.694 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.554522e-01 0.808 0 0
Heme signaling R-HSA-9707616 1.910765e-01 0.719 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.992480e-01 0.399 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 4.369032e-01 0.360 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.169207e-01 0.499 0 0
Meiotic recombination R-HSA-912446 4.070408e-01 0.390 0 0
DNA Replication Pre-Initiation R-HSA-69002 2.259223e-01 0.646 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.292302e-01 0.640 0 0
Neurodegenerative Diseases R-HSA-8863678 2.292302e-01 0.640 0 0
Mismatch Repair R-HSA-5358508 1.345716e-01 0.871 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 2.021511e-01 0.694 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 2.338705e-01 0.631 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 3.902868e-01 0.409 1 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 3.412577e-01 0.467 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.351836e-01 0.361 0 0
Clathrin-mediated endocytosis R-HSA-8856828 3.925181e-01 0.406 0 0
ER to Golgi Anterograde Transport R-HSA-199977 4.216201e-01 0.375 0 0
Signaling by FGFR1 R-HSA-5654736 1.442955e-01 0.841 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 1.418144e-01 0.848 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 3.175014e-01 0.498 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.729820e-01 0.564 0 0
p75NTR signals via NF-kB R-HSA-193639 2.805114e-01 0.552 0 0
Signaling by FGFR R-HSA-190236 2.542406e-01 0.595 0 0
Polo-like kinase mediated events R-HSA-156711 1.345716e-01 0.871 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.086366e-01 0.511 1 1
Signaling by Erythropoietin R-HSA-9006335 3.026197e-01 0.519 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 1.520143e-01 0.818 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 1.973705e-01 0.705 1 0
MET interacts with TNS proteins R-HSA-8875513 2.403034e-01 0.619 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 2.809423e-01 0.551 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.809423e-01 0.551 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 1.999676e-01 0.699 0 0
PDE3B signalling R-HSA-165160 3.558212e-01 0.449 0 0
Synthesis of PS R-HSA-1483101 3.558212e-01 0.449 0 0
PKB-mediated events R-HSA-109703 3.558212e-01 0.449 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 3.558212e-01 0.449 1 0
Phosphorylation of Emi1 R-HSA-176417 3.558212e-01 0.449 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.400759e-01 0.620 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.870107e-01 0.728 0 0
CREB phosphorylation R-HSA-199920 3.902868e-01 0.409 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.805114e-01 0.552 0 0
Orc1 removal from chromatin R-HSA-68949 1.164433e-01 0.934 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 4.229104e-01 0.374 0 0
Mitochondrial ABC transporters R-HSA-1369007 4.229104e-01 0.374 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 1.790620e-01 0.747 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 3.407077e-01 0.468 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 3.604562e-01 0.443 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.601849e-01 0.585 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 3.799805e-01 0.420 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 3.769093e-01 0.424 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.825103e-01 0.417 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.825103e-01 0.417 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.744589e-01 0.427 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 3.349391e-01 0.475 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.021511e-01 0.694 0 0
Co-stimulation by CD28 R-HSA-389356 1.976782e-01 0.704 0 0
Chaperone Mediated Autophagy R-HSA-9613829 3.604562e-01 0.443 0 0
Chromosome Maintenance R-HSA-73886 3.266638e-01 0.486 0 0
Mitotic Anaphase R-HSA-68882 1.607754e-01 0.794 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.277141e-01 0.894 0 0
Nuclear RNA decay R-HSA-9930044 3.621175e-01 0.441 0 0
Signaling by FGFR1 in disease R-HSA-5655302 2.842566e-01 0.546 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.647260e-01 0.783 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.636024e-01 0.786 0 0
Vesicle-mediated transport R-HSA-5653656 4.344206e-01 0.362 0 0
ABC transporter disorders R-HSA-5619084 3.360347e-01 0.474 0 0
Signaling by MET R-HSA-6806834 1.162707e-01 0.935 0 0
Signaling by VEGF R-HSA-194138 1.540436e-01 0.812 0 0
HSF1 activation R-HSA-3371511 4.207818e-01 0.376 0 0
DAP12 interactions R-HSA-2172127 1.611489e-01 0.793 0 0
TCR signaling R-HSA-202403 2.327191e-01 0.633 0 0
Elastic fibre formation R-HSA-1566948 4.494497e-01 0.347 0 0
Autophagy R-HSA-9612973 3.621453e-01 0.441 0 0
ABC-family proteins mediated transport R-HSA-382556 2.695205e-01 0.569 0 0
Muscarinic acetylcholine receptors R-HSA-390648 3.194096e-01 0.496 0 0
Signaling by FGFR4 in disease R-HSA-5655291 2.602867e-01 0.585 0 0
p38MAPK events R-HSA-171007 2.805114e-01 0.552 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 1.694331e-01 0.771 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 4.229104e-01 0.374 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.436835e-01 0.613 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.436835e-01 0.613 0 0
FGFR1 mutant receptor activation R-HSA-1839124 3.621175e-01 0.441 0 0
DNA Replication R-HSA-69306 3.417061e-01 0.466 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.721748e-01 0.565 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.008095e-01 0.522 0 0
Cellular Senescence R-HSA-2559583 4.131382e-01 0.384 0 0
HIV Infection R-HSA-162906 2.882510e-01 0.540 0 0
Macroautophagy R-HSA-1632852 2.564661e-01 0.591 0 0
Axon guidance R-HSA-422475 2.082660e-01 0.681 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.454759e-01 0.837 1 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 3.992480e-01 0.399 0 0
Regulation of KIT signaling R-HSA-1433559 2.602867e-01 0.585 0 0
RET signaling R-HSA-8853659 4.207818e-01 0.376 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 3.552739e-01 0.449 0 0
Synthesis of DNA R-HSA-69239 2.125609e-01 0.673 0 0
Nervous system development R-HSA-9675108 1.703989e-01 0.769 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.479851e-01 0.606 0 0
Signaling by FGFR in disease R-HSA-1226099 2.979838e-01 0.526 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 1.393767e-01 0.856 0 0
Selective autophagy R-HSA-9663891 1.695537e-01 0.771 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.403034e-01 0.619 0 0
TGFBR3 PTM regulation R-HSA-9839383 1.233558e-01 0.909 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.418144e-01 0.848 0 0
NADE modulates death signalling R-HSA-205025 2.809423e-01 0.551 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 3.558212e-01 0.449 0 0
Abacavir transmembrane transport R-HSA-2161517 3.902868e-01 0.409 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.149465e-01 0.668 0 0
Negative regulation of FLT3 R-HSA-9706369 3.006908e-01 0.522 0 0
VLDL clearance R-HSA-8964046 4.229104e-01 0.374 0 0
Ca2+ activated K+ channels R-HSA-1296052 4.229104e-01 0.374 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 3.407077e-01 0.468 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.604562e-01 0.443 0 0
Specification of the neural plate border R-HSA-9834899 3.799805e-01 0.420 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.393122e-01 0.357 0 0
Developmental Biology R-HSA-1266738 4.003571e-01 0.398 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 3.900373e-01 0.409 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.026197e-01 0.519 0 0
MTOR signalling R-HSA-165159 2.964154e-01 0.528 0 0
Uptake and function of anthrax toxins R-HSA-5210891 3.407077e-01 0.468 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 2.877717e-01 0.541 0 0
Signaling by ERBB4 R-HSA-1236394 2.979838e-01 0.526 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.418144e-01 0.848 0 0
PECAM1 interactions R-HSA-210990 1.802250e-01 0.744 0 0
ERK/MAPK targets R-HSA-198753 1.734223e-01 0.761 0 0
Kinesins R-HSA-983189 1.748724e-01 0.757 0 0
tRNA processing in the nucleus R-HSA-6784531 1.910765e-01 0.719 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.369032e-01 0.360 0 0
Signaling by TGFB family members R-HSA-9006936 1.871853e-01 0.728 1 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.842691e-01 0.415 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.262201e-01 0.370 0 0
Signaling by NTRKs R-HSA-166520 3.081618e-01 0.511 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.292302e-01 0.640 0 0
GAB1 signalosome R-HSA-180292 3.604562e-01 0.443 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.744589e-01 0.427 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.281734e-01 0.368 0 0
FLT3 signaling in disease R-HSA-9682385 2.134501e-01 0.671 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.748724e-01 0.757 0 0
DNA Damage Bypass R-HSA-73893 2.072267e-01 0.684 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.601849e-01 0.585 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.842566e-01 0.546 0 0
L1CAM interactions R-HSA-373760 2.894884e-01 0.538 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 4.187239e-01 0.378 0 0
Post NMDA receptor activation events R-HSA-438064 4.324986e-01 0.364 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 3.194096e-01 0.496 0 0
Signaling by LTK in cancer R-HSA-9842640 3.902868e-01 0.409 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.902868e-01 0.409 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.199012e-01 0.921 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.277141e-01 0.894 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 3.006908e-01 0.522 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 4.229104e-01 0.374 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 4.229104e-01 0.374 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 4.369032e-01 0.360 0 0
Signaling by FGFR2 in disease R-HSA-5655253 3.947951e-01 0.404 0 0
Cellular responses to stress R-HSA-2262752 1.556912e-01 0.808 0 0
Cellular responses to stimuli R-HSA-8953897 1.675320e-01 0.776 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.211810e-01 0.917 0 0
Amino acid transport across the plasma membrane R-HSA-352230 3.092248e-01 0.510 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.057531e-01 0.392 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.877036e-01 0.412 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.589731e-01 0.799 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 3.769093e-01 0.424 0 0
SLC-mediated transport of amino acids R-HSA-9958863 3.950195e-01 0.403 0 0
Mitochondrial biogenesis R-HSA-1592230 4.311184e-01 0.365 0 0
Signalling to ERKs R-HSA-187687 4.062584e-01 0.391 0 0
RUNX2 regulates bone development R-HSA-8941326 4.207818e-01 0.376 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 3.175014e-01 0.498 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 2.677463e-01 0.572 0 0
FLT3 Signaling R-HSA-9607240 2.721748e-01 0.565 0 0
Regulated proteolysis of p75NTR R-HSA-193692 1.418144e-01 0.848 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 1.418144e-01 0.848 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.999676e-01 0.699 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.558212e-01 0.449 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 3.558212e-01 0.449 0 0
Signal regulatory protein family interactions R-HSA-391160 2.602867e-01 0.585 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.602867e-01 0.585 0 0
Nef and signal transduction R-HSA-164944 3.902868e-01 0.409 0 0
HDL clearance R-HSA-8964011 3.902868e-01 0.409 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 2.008629e-01 0.697 0 0
Cell-extracellular matrix interactions R-HSA-446353 2.805114e-01 0.552 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 2.805114e-01 0.552 0 0
CHL1 interactions R-HSA-447041 4.229104e-01 0.374 0 0
Basigin interactions R-HSA-210991 4.182304e-01 0.379 0 0
Semaphorin interactions R-HSA-373755 3.519955e-01 0.453 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.483720e-01 0.348 0 0
ESR-mediated signaling R-HSA-8939211 3.422896e-01 0.466 0 0
Disorders of transmembrane transporters R-HSA-5619115 3.982717e-01 0.400 0 0
Signaling by ROBO receptors R-HSA-376176 4.471487e-01 0.350 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.608543e-01 0.584 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.935335e-01 0.532 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 1.421456e-01 0.847 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.776539e-01 0.556 0 0
Signaling by TGFBR3 R-HSA-9839373 1.790620e-01 0.747 1 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 3.604562e-01 0.443 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.611489e-01 0.793 0 0
Activation of BH3-only proteins R-HSA-114452 3.175014e-01 0.498 0 0
Influenza Infection R-HSA-168255 2.976915e-01 0.526 0 0
Gene Silencing by RNA R-HSA-211000 3.328616e-01 0.478 0 0
Neurofascin interactions R-HSA-447043 3.902868e-01 0.409 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 2.805114e-01 0.552 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.365413e-01 0.626 0 0
Tie2 Signaling R-HSA-210993 3.604562e-01 0.443 0 0
Maturation of nucleoprotein R-HSA-9694631 3.799805e-01 0.420 0 0
Inositol phosphate metabolism R-HSA-1483249 3.736181e-01 0.428 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 4.182304e-01 0.379 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 2.367189e-01 0.626 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 4.229104e-01 0.374 1 1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 4.351836e-01 0.361 0 0
Interleukin-7 signaling R-HSA-1266695 2.436835e-01 0.613 0 0
MHC class II antigen presentation R-HSA-2132295 3.417882e-01 0.466 0 0
NOD1/2 Signaling Pathway R-HSA-168638 3.916288e-01 0.407 0 0
STING mediated induction of host immune responses R-HSA-1834941 3.799805e-01 0.420 0 0
Signaling by NOTCH1 R-HSA-1980143 1.836812e-01 0.736 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 2.400759e-01 0.620 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 2.400759e-01 0.620 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 3.407077e-01 0.468 0 0
XBP1(S) activates chaperone genes R-HSA-381038 1.568614e-01 0.804 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 2.163931e-01 0.665 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 3.621175e-01 0.441 0 0
Potential therapeutics for SARS R-HSA-9679191 3.214879e-01 0.493 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 2.602867e-01 0.585 0 0
Early Phase of HIV Life Cycle R-HSA-162594 4.182304e-01 0.379 0 0
IRE1alpha activates chaperones R-HSA-381070 1.962609e-01 0.707 0 0
SARS-CoV Infections R-HSA-9679506 2.962409e-01 0.528 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 3.799805e-01 0.420 0 0
Unfolded Protein Response (UPR) R-HSA-381119 2.440311e-01 0.613 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 2.072267e-01 0.684 0 0
Interleukin-12 signaling R-HSA-9020591 3.169207e-01 0.499 0 0
Interleukin-12 family signaling R-HSA-447115 4.324986e-01 0.364 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.537903e-01 0.343 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 4.537903e-01 0.343 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 4.537903e-01 0.343 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 4.537903e-01 0.343 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 4.537903e-01 0.343 0 0
Co-stimulation by ICOS R-HSA-9927354 4.537903e-01 0.343 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 4.537903e-01 0.343 0 0
Sodium/Proton exchangers R-HSA-425986 4.537903e-01 0.343 0 0
Adrenoceptors R-HSA-390696 4.537903e-01 0.343 0 0
FGFR2 alternative splicing R-HSA-6803529 4.552450e-01 0.342 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 4.552450e-01 0.342 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 4.552450e-01 0.342 1 1
Signaling by KIT in disease R-HSA-9669938 4.552450e-01 0.342 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.554286e-01 0.342 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 4.554286e-01 0.342 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 4.635672e-01 0.334 0 0
Stabilization of p53 R-HSA-69541 4.635672e-01 0.334 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 4.635672e-01 0.334 0 0
Estrogen-dependent gene expression R-HSA-9018519 4.645753e-01 0.333 0 0
SARS-CoV-2 Infection R-HSA-9694516 4.660293e-01 0.332 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.673297e-01 0.330 0 0
NRAGE signals death through JNK R-HSA-193648 4.673297e-01 0.330 0 0
Signaling by NOTCH4 R-HSA-9013694 4.693965e-01 0.328 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 4.706381e-01 0.327 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.714139e-01 0.327 0 0
Interleukin receptor SHC signaling R-HSA-912526 4.732380e-01 0.325 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.732380e-01 0.325 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.732380e-01 0.325 0 0
Syndecan interactions R-HSA-3000170 4.732380e-01 0.325 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 4.775240e-01 0.321 0 0
Diseases of Immune System R-HSA-5260271 4.775240e-01 0.321 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 4.775240e-01 0.321 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 4.775240e-01 0.321 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 4.775240e-01 0.321 0 0
Ribosome-associated quality control R-HSA-9948299 4.797953e-01 0.319 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.800682e-01 0.319 0 0
ALK mutants bind TKIs R-HSA-9700645 4.830196e-01 0.316 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.830196e-01 0.316 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.830196e-01 0.316 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.830196e-01 0.316 0 0
Lipophagy R-HSA-9613354 4.830196e-01 0.316 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 4.830196e-01 0.316 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 4.830196e-01 0.316 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.860979e-01 0.313 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.860979e-01 0.313 0 0
PTEN Regulation R-HSA-6807070 4.873689e-01 0.312 0 0
Host Interactions of HIV factors R-HSA-162909 4.880398e-01 0.312 0 0
Eukaryotic Translation Elongation R-HSA-156842 4.894474e-01 0.310 0 0
UCH proteinases R-HSA-5689603 4.901643e-01 0.310 1 1
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.908380e-01 0.309 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 4.908668e-01 0.309 0 0
Deadenylation of mRNA R-HSA-429947 4.908668e-01 0.309 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.908668e-01 0.309 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.908668e-01 0.309 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 4.913091e-01 0.309 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.987713e-01 0.302 0 0
SARS-CoV-1 Infection R-HSA-9678108 4.996912e-01 0.301 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.024301e-01 0.299 0 0
Extension of Telomeres R-HSA-180786 5.024301e-01 0.299 0 0
Regulation of beta-cell development R-HSA-186712 5.024301e-01 0.299 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.040435e-01 0.298 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.040435e-01 0.298 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.040435e-01 0.298 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.049126e-01 0.297 0 0
HIV Transcription Initiation R-HSA-167161 5.049126e-01 0.297 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.049126e-01 0.297 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 5.049126e-01 0.297 0 0
Long-term potentiation R-HSA-9620244 5.081191e-01 0.294 0 0
Acyl chain remodelling of PS R-HSA-1482801 5.081191e-01 0.294 0 0
Laminin interactions R-HSA-3000157 5.081191e-01 0.294 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 5.081191e-01 0.294 0 0
TGFBR3 expression R-HSA-9839394 5.081191e-01 0.294 0 0
Integrin cell surface interactions R-HSA-216083 5.106308e-01 0.292 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 5.106864e-01 0.292 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 5.106864e-01 0.292 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.106864e-01 0.292 0 0
Regulation of CDH11 function R-HSA-9762292 5.106864e-01 0.292 0 0
2-LTR circle formation R-HSA-164843 5.106864e-01 0.292 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 5.106864e-01 0.292 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 5.106864e-01 0.292 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 5.106864e-01 0.292 0 0
Pexophagy R-HSA-9664873 5.106864e-01 0.292 0 0
MAPK3 (ERK1) activation R-HSA-110056 5.106864e-01 0.292 0 0
Josephin domain DUBs R-HSA-5689877 5.106864e-01 0.292 0 0
Signaling by Leptin R-HSA-2586552 5.106864e-01 0.292 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.173636e-01 0.286 0 0
HCMV Early Events R-HSA-9609690 5.178566e-01 0.286 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 5.228384e-01 0.282 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 5.228384e-01 0.282 0 0
MET activates PTK2 signaling R-HSA-8874081 5.249845e-01 0.280 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 5.249845e-01 0.280 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.249845e-01 0.280 0 0
Metalloprotease DUBs R-HSA-5689901 5.249845e-01 0.280 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.249845e-01 0.280 0 0
Formation of a pool of free 40S subunits R-HSA-72689 5.263707e-01 0.279 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.263707e-01 0.279 0 0
Eukaryotic Translation Termination R-HSA-72764 5.263707e-01 0.279 0 0
PKR-mediated signaling R-HSA-9833482 5.307553e-01 0.275 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 5.315392e-01 0.274 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 5.315392e-01 0.274 0 0
Signaling by SCF-KIT R-HSA-1433557 5.315392e-01 0.274 0 0
TBC/RABGAPs R-HSA-8854214 5.315392e-01 0.274 0 0
Signaling by PDGF R-HSA-186797 5.364785e-01 0.270 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.364785e-01 0.270 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 5.368742e-01 0.270 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 5.368742e-01 0.270 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 5.368742e-01 0.270 0 0
Synthesis of PI R-HSA-1483226 5.368742e-01 0.270 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 5.368742e-01 0.270 0 0
Suppression of apoptosis R-HSA-9635465 5.368742e-01 0.270 0 0
Transport of RCbl within the body R-HSA-9758890 5.368742e-01 0.270 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 5.368742e-01 0.270 0 0
Prostanoid ligand receptors R-HSA-391908 5.368742e-01 0.270 0 0
Interleukin-2 signaling R-HSA-9020558 5.368742e-01 0.270 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.406778e-01 0.267 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 5.414552e-01 0.266 0 0
Signaling by FGFR3 in disease R-HSA-5655332 5.414552e-01 0.266 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.414552e-01 0.266 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 5.414552e-01 0.266 0 0
Telomere Maintenance R-HSA-157579 5.444229e-01 0.264 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.444229e-01 0.264 0 0
RMTs methylate histone arginines R-HSA-3214858 5.445469e-01 0.264 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.475657e-01 0.262 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 5.475657e-01 0.262 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.475657e-01 0.262 0 0
Signaling by PTK6 R-HSA-8848021 5.475657e-01 0.262 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.475657e-01 0.262 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.498857e-01 0.260 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.525394e-01 0.258 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.573419e-01 0.254 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.573419e-01 0.254 0 0
Nucleosome assembly R-HSA-774815 5.573419e-01 0.254 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 5.573419e-01 0.254 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.575250e-01 0.254 0 0
Telomere Extension By Telomerase R-HSA-171319 5.575250e-01 0.254 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 5.575250e-01 0.254 0 0
Insulin receptor signalling cascade R-HSA-74751 5.585130e-01 0.253 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.602225e-01 0.252 0 0
DS-GAG biosynthesis R-HSA-2022923 5.616619e-01 0.251 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 5.616619e-01 0.251 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 5.616619e-01 0.251 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.616619e-01 0.251 0 0
Signaling by GSK3beta mutants R-HSA-5339716 5.616619e-01 0.251 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 5.616619e-01 0.251 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 5.616619e-01 0.251 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 5.616619e-01 0.251 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 5.616619e-01 0.251 0 0
Activation of RAC1 R-HSA-428540 5.616619e-01 0.251 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 5.616619e-01 0.251 0 0
Integration of provirus R-HSA-162592 5.616619e-01 0.251 0 0
Uptake of dietary cobalamins into enterocytes R-HSA-9758881 5.616619e-01 0.251 0 0
HATs acetylate histones R-HSA-3214847 5.621652e-01 0.250 0 0
FOXO-mediated transcription R-HSA-9614085 5.621652e-01 0.250 0 0
SLC transporter disorders R-HSA-5619102 5.636554e-01 0.249 0 0
Signaling by NOTCH R-HSA-157118 5.669571e-01 0.246 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 5.693158e-01 0.245 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.698371e-01 0.244 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.699185e-01 0.244 0 0
Glycolysis R-HSA-70171 5.709126e-01 0.243 0 0
Late endosomal microautophagy R-HSA-9615710 5.731897e-01 0.242 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.731897e-01 0.242 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.731897e-01 0.242 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.731897e-01 0.242 0 0
Cell-Cell communication R-HSA-1500931 5.757453e-01 0.240 0 0
Meiosis R-HSA-1500620 5.793420e-01 0.237 0 0
Oncogenic MAPK signaling R-HSA-6802957 5.793420e-01 0.237 0 0
Protein-protein interactions at synapses R-HSA-6794362 5.793420e-01 0.237 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 5.793420e-01 0.237 0 0
AURKA Activation by TPX2 R-HSA-8854518 5.799699e-01 0.237 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.822718e-01 0.235 0 0
Recycling pathway of L1 R-HSA-437239 5.822718e-01 0.235 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.851243e-01 0.233 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 5.851243e-01 0.233 0 0
Scavenging by Class F Receptors R-HSA-3000484 5.851243e-01 0.233 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 5.851243e-01 0.233 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 5.851243e-01 0.233 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 5.851243e-01 0.233 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 5.851243e-01 0.233 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.851243e-01 0.233 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.851243e-01 0.233 0 0
Regulation of IFNG signaling R-HSA-877312 5.851243e-01 0.233 0 0
p75NTR recruits signalling complexes R-HSA-209543 5.851243e-01 0.233 0 0
MET activates RAS signaling R-HSA-8851805 5.851243e-01 0.233 0 0
Interleukin-15 signaling R-HSA-8983432 5.851243e-01 0.233 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 5.851243e-01 0.233 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.851243e-01 0.233 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 5.851243e-01 0.233 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.851243e-01 0.233 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.851243e-01 0.233 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.851243e-01 0.233 0 0
OAS antiviral response R-HSA-8983711 5.851243e-01 0.233 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 5.881456e-01 0.231 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 5.881456e-01 0.231 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.884467e-01 0.230 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 5.884467e-01 0.230 0 0
Interleukin-37 signaling R-HSA-9008059 5.884467e-01 0.230 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 5.887339e-01 0.230 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.895029e-01 0.230 0 0
GPER1 signaling R-HSA-9634597 5.943975e-01 0.226 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 5.943975e-01 0.226 0 0
Organelle biogenesis and maintenance R-HSA-1852241 5.957025e-01 0.225 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.960867e-01 0.225 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 6.032946e-01 0.219 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.032946e-01 0.219 0 0
Cargo concentration in the ER R-HSA-5694530 6.032946e-01 0.219 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 6.032946e-01 0.219 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.035804e-01 0.219 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.050131e-01 0.218 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 6.050131e-01 0.218 0 0
Degradation of CDH1 R-HSA-9766229 6.062921e-01 0.217 0 0
Gap junction trafficking and regulation R-HSA-157858 6.062921e-01 0.217 0 0
Chaperonin-mediated protein folding R-HSA-390466 6.071674e-01 0.217 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 6.073323e-01 0.217 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 6.073323e-01 0.217 0 0
CD28 dependent Vav1 pathway R-HSA-389359 6.073323e-01 0.217 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 6.073323e-01 0.217 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 6.073323e-01 0.217 0 0
Maturation of nucleoprotein R-HSA-9683610 6.073323e-01 0.217 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 6.073323e-01 0.217 0 0
Interleukin-6 signaling R-HSA-1059683 6.073323e-01 0.217 0 0
Peptide chain elongation R-HSA-156902 6.162038e-01 0.210 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 6.177336e-01 0.209 0 0
PI3K Cascade R-HSA-109704 6.179526e-01 0.209 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.210282e-01 0.207 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.283527e-01 0.202 0 0
CRMPs in Sema3A signaling R-HSA-399956 6.283527e-01 0.202 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 6.283527e-01 0.202 0 0
cGMP effects R-HSA-418457 6.283527e-01 0.202 0 0
Zinc transporters R-HSA-435354 6.283527e-01 0.202 0 0
Hedgehog ligand biogenesis R-HSA-5358346 6.293767e-01 0.201 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.317648e-01 0.199 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 6.317648e-01 0.199 0 0
G-protein beta:gamma signalling R-HSA-397795 6.317648e-01 0.199 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 6.317648e-01 0.199 0 0
Signal Transduction R-HSA-162582 6.335489e-01 0.198 1 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.345220e-01 0.198 0 0
MAPK family signaling cascades R-HSA-5683057 6.348672e-01 0.197 0 0
Neurexins and neuroligins R-HSA-6794361 6.405625e-01 0.193 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 6.405625e-01 0.193 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 6.453906e-01 0.190 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 6.482491e-01 0.188 1 1
SHC1 events in EGFR signaling R-HSA-180336 6.482491e-01 0.188 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 6.482491e-01 0.188 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 6.482491e-01 0.188 0 0
G beta:gamma signalling through BTK R-HSA-8964315 6.482491e-01 0.188 0 0
DCC mediated attractive signaling R-HSA-418885 6.482491e-01 0.188 0 0
Erythropoietin activates RAS R-HSA-9027284 6.482491e-01 0.188 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.482491e-01 0.188 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 6.482491e-01 0.188 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 6.482491e-01 0.188 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.482491e-01 0.188 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 6.482491e-01 0.188 0 0
Processive synthesis on the lagging strand R-HSA-69183 6.482491e-01 0.188 0 0
Protein methylation R-HSA-8876725 6.482491e-01 0.188 0 0
DNA Damage Reversal R-HSA-73942 6.482491e-01 0.188 0 0
Regulation of PTEN stability and activity R-HSA-8948751 6.515089e-01 0.186 0 0
Adherens junctions interactions R-HSA-418990 6.564746e-01 0.183 0 0
Hemostasis R-HSA-109582 6.567760e-01 0.183 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.582776e-01 0.182 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 6.586141e-01 0.181 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.586141e-01 0.181 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.586141e-01 0.181 0 0
Gap junction assembly R-HSA-190861 6.586141e-01 0.181 0 0
Mitophagy R-HSA-5205647 6.586141e-01 0.181 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.586141e-01 0.181 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.586141e-01 0.181 0 0
Protein folding R-HSA-391251 6.594982e-01 0.181 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.622151e-01 0.179 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 6.622151e-01 0.179 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.630877e-01 0.178 0 0
Platelet degranulation R-HSA-114608 6.631464e-01 0.178 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 6.670814e-01 0.176 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.670814e-01 0.176 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 6.670814e-01 0.176 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 6.670814e-01 0.176 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 6.670814e-01 0.176 0 0
Atorvastatin ADME R-HSA-9754706 6.670814e-01 0.176 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 6.677681e-01 0.175 0 0
Cell junction organization R-HSA-446728 6.687106e-01 0.175 0 0
Regulation of Apoptosis R-HSA-169911 6.714394e-01 0.173 0 0
TCF dependent signaling in response to WNT R-HSA-201681 6.718331e-01 0.173 0 0
Signaling by NOTCH3 R-HSA-9012852 6.726806e-01 0.172 0 0
TNF signaling R-HSA-75893 6.829058e-01 0.166 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 6.829058e-01 0.166 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 6.838712e-01 0.165 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 6.838712e-01 0.165 0 0
GPVI-mediated activation cascade R-HSA-114604 6.838712e-01 0.165 0 0
FGFR2 mutant receptor activation R-HSA-1839126 6.838712e-01 0.165 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.839092e-01 0.165 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.849065e-01 0.164 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 6.849065e-01 0.164 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 6.849065e-01 0.164 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 6.849065e-01 0.164 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 6.849065e-01 0.164 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 6.849065e-01 0.164 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.849065e-01 0.164 0 0
Fibronectin matrix formation R-HSA-1566977 6.849065e-01 0.164 0 0
Synthesis of PG R-HSA-1483148 6.849065e-01 0.164 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 6.849065e-01 0.164 0 0
Developmental Cell Lineages R-HSA-9734767 6.896295e-01 0.161 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.915800e-01 0.160 0 0
IRS-mediated signalling R-HSA-112399 6.928912e-01 0.159 0 0
Regulation of CDH1 Function R-HSA-9764561 6.928912e-01 0.159 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 6.928912e-01 0.159 0 0
G alpha (12/13) signalling events R-HSA-416482 6.951796e-01 0.158 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.959147e-01 0.157 0 0
Degradation of AXIN R-HSA-4641257 6.959147e-01 0.157 0 0
Adipogenesis R-HSA-9843745 6.973122e-01 0.157 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 7.017783e-01 0.154 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 7.017783e-01 0.154 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 7.017783e-01 0.154 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 7.017783e-01 0.154 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 7.017783e-01 0.154 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.026375e-01 0.153 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.036769e-01 0.153 0 0
Circadian clock R-HSA-9909396 7.038665e-01 0.153 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 7.047301e-01 0.152 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.100621e-01 0.149 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.103265e-01 0.149 0 0
Cilium Assembly R-HSA-5617833 7.114654e-01 0.148 0 0
Interferon Signaling R-HSA-913531 7.116272e-01 0.148 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 7.120016e-01 0.148 0 0
Cellular response to chemical stress R-HSA-9711123 7.134202e-01 0.147 0 0
Nephron development R-HSA-9831926 7.177477e-01 0.144 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.177477e-01 0.144 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.177477e-01 0.144 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 7.177477e-01 0.144 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 7.177477e-01 0.144 0 0
Platelet sensitization by LDL R-HSA-432142 7.177477e-01 0.144 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 7.177477e-01 0.144 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.177477e-01 0.144 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.177477e-01 0.144 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.188615e-01 0.143 0 0
RAF/MAP kinase cascade R-HSA-5673001 7.200648e-01 0.143 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.214186e-01 0.142 0 0
Glucose metabolism R-HSA-70326 7.251348e-01 0.140 0 0
Cell-cell junction organization R-HSA-421270 7.255763e-01 0.139 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.297779e-01 0.137 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 7.297779e-01 0.137 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 7.297779e-01 0.137 0 0
Interleukin-2 family signaling R-HSA-451927 7.297779e-01 0.137 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 7.304568e-01 0.136 0 0
MAP kinase activation R-HSA-450294 7.304568e-01 0.136 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.328628e-01 0.135 0 0
Pyrimidine biosynthesis R-HSA-500753 7.328628e-01 0.135 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 7.328628e-01 0.135 0 0
Rap1 signalling R-HSA-392517 7.328628e-01 0.135 0 0
Translesion Synthesis by POLH R-HSA-110320 7.328628e-01 0.135 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.328628e-01 0.135 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.328628e-01 0.135 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.328628e-01 0.135 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 7.328628e-01 0.135 0 0
Selenocysteine synthesis R-HSA-2408557 7.361572e-01 0.133 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.381789e-01 0.132 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.381789e-01 0.132 0 0
Translation R-HSA-72766 7.391593e-01 0.131 0 0
NCAM signaling for neurite out-growth R-HSA-375165 7.392629e-01 0.131 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.392629e-01 0.131 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.392629e-01 0.131 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 7.403324e-01 0.131 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 7.403324e-01 0.131 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 7.435829e-01 0.129 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.471693e-01 0.127 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 7.471693e-01 0.127 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 7.471693e-01 0.127 0 0
Formation of definitive endoderm R-HSA-9823730 7.471693e-01 0.127 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 7.471693e-01 0.127 0 0
Nephrin family interactions R-HSA-373753 7.471693e-01 0.127 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.471693e-01 0.127 0 0
Viral mRNA Translation R-HSA-192823 7.498684e-01 0.125 0 0
MAP2K and MAPK activation R-HSA-5674135 7.505324e-01 0.125 0 0
Signaling by RAF1 mutants R-HSA-9656223 7.505324e-01 0.125 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 7.505324e-01 0.125 0 0
Adaptive Immune System R-HSA-1280218 7.532088e-01 0.123 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.561883e-01 0.121 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.569070e-01 0.121 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.569070e-01 0.121 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 7.603855e-01 0.119 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 7.607105e-01 0.119 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 7.607105e-01 0.119 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.607105e-01 0.119 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 7.607105e-01 0.119 0 0
Lagging Strand Synthesis R-HSA-69186 7.607105e-01 0.119 0 0
Co-inhibition by PD-1 R-HSA-389948 7.625345e-01 0.118 0 0
Viral Infection Pathways R-HSA-9824446 7.648288e-01 0.116 0 0
Neutrophil degranulation R-HSA-6798695 7.682647e-01 0.114 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 7.694314e-01 0.114 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 7.719491e-01 0.112 0 0
CS-GAG biosynthesis R-HSA-2022870 7.735272e-01 0.112 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 7.735272e-01 0.112 0 0
Serine metabolism R-HSA-977347 7.735272e-01 0.112 0 0
Intracellular signaling by second messengers R-HSA-9006925 7.749983e-01 0.111 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 7.790832e-01 0.108 0 0
Netrin-1 signaling R-HSA-373752 7.790832e-01 0.108 0 0
Methylation R-HSA-156581 7.790832e-01 0.108 0 0
Gap junction trafficking R-HSA-190828 7.790832e-01 0.108 0 0
Cyclin D associated events in G1 R-HSA-69231 7.790832e-01 0.108 0 0
G1 Phase R-HSA-69236 7.790832e-01 0.108 0 0
Amine ligand-binding receptors R-HSA-375280 7.790832e-01 0.108 0 0
Signaling by Nuclear Receptors R-HSA-9006931 7.792646e-01 0.108 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 7.818128e-01 0.107 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 7.856582e-01 0.105 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.856582e-01 0.105 0 0
mTORC1-mediated signalling R-HSA-166208 7.856582e-01 0.105 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.856582e-01 0.105 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 7.856582e-01 0.105 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 7.856582e-01 0.105 0 0
LDL clearance R-HSA-8964038 7.856582e-01 0.105 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 7.856582e-01 0.105 0 0
ER-Phagosome pathway R-HSA-1236974 7.859069e-01 0.105 0 0
Somitogenesis R-HSA-9824272 7.879438e-01 0.104 0 0
Base Excision Repair R-HSA-73884 7.923899e-01 0.101 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 7.964899e-01 0.099 0 0
Signaling downstream of RAS mutants R-HSA-9649948 7.964899e-01 0.099 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 7.964899e-01 0.099 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 7.964899e-01 0.099 0 0
Signaling by RAS mutants R-HSA-6802949 7.964899e-01 0.099 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 7.971400e-01 0.098 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 7.971400e-01 0.098 0 0
Growth hormone receptor signaling R-HSA-982772 7.971400e-01 0.098 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 7.994134e-01 0.097 0 0
MyD88-independent TLR4 cascade R-HSA-166166 7.994134e-01 0.097 0 0
Interleukin-17 signaling R-HSA-448424 8.016819e-01 0.096 0 0
Post-translational protein modification R-HSA-597592 8.044052e-01 0.095 1 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 8.047296e-01 0.094 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.047296e-01 0.094 0 0
HCMV Infection R-HSA-9609646 8.065779e-01 0.093 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.080075e-01 0.093 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 8.080075e-01 0.093 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.080075e-01 0.093 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.080075e-01 0.093 0 0
Interleukin-6 family signaling R-HSA-6783589 8.080075e-01 0.093 0 0
ECM proteoglycans R-HSA-3000178 8.085286e-01 0.092 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.085286e-01 0.092 0 0
Signaling by Insulin receptor R-HSA-74752 8.108961e-01 0.091 0 0
Intraflagellar transport R-HSA-5620924 8.126714e-01 0.090 0 0
NGF-stimulated transcription R-HSA-9031628 8.126714e-01 0.090 0 0
Metal ion SLC transporters R-HSA-425410 8.126714e-01 0.090 0 0
tRNA processing R-HSA-72306 8.142471e-01 0.089 0 0
Toll-like Receptor Cascades R-HSA-168898 8.143283e-01 0.089 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.182934e-01 0.087 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.182934e-01 0.087 0 0
Formation of the nephric duct R-HSA-9830364 8.182934e-01 0.087 0 0
Hyaluronan degradation R-HSA-2160916 8.182934e-01 0.087 0 0
Sema4D in semaphorin signaling R-HSA-400685 8.182934e-01 0.087 0 0
Defects in cobalamin (B12) metabolism R-HSA-3296469 8.182934e-01 0.087 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.182934e-01 0.087 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.184696e-01 0.087 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 8.203234e-01 0.086 0 0
Regulation of RAS by GAPs R-HSA-5658442 8.276938e-01 0.082 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 8.280288e-01 0.082 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.280288e-01 0.082 0 0
TRP channels R-HSA-3295583 8.280288e-01 0.082 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 8.280288e-01 0.082 0 0
Abacavir ADME R-HSA-2161522 8.280288e-01 0.082 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 8.280288e-01 0.082 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.280324e-01 0.082 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 8.347910e-01 0.078 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 8.347910e-01 0.078 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 8.372432e-01 0.077 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 8.372432e-01 0.077 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 8.372432e-01 0.077 0 0
Triglyceride biosynthesis R-HSA-75109 8.372432e-01 0.077 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.372432e-01 0.077 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 8.387254e-01 0.076 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.416229e-01 0.075 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 8.416229e-01 0.075 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 8.416229e-01 0.075 0 0
Translation of Structural Proteins R-HSA-9694635 8.455331e-01 0.073 0 0
Prednisone ADME R-HSA-9757110 8.459644e-01 0.073 0 0
Cytokine Signaling in Immune system R-HSA-1280215 8.478075e-01 0.072 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 8.481977e-01 0.072 0 0
Meiotic synapsis R-HSA-1221632 8.481977e-01 0.072 0 0
Signaling by Interleukins R-HSA-449147 8.487477e-01 0.071 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 8.488556e-01 0.071 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 8.488556e-01 0.071 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 8.488556e-01 0.071 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 8.492789e-01 0.071 0 0
Cellular response to starvation R-HSA-9711097 8.492789e-01 0.071 0 0
PCP/CE pathway R-HSA-4086400 8.510578e-01 0.070 0 0
Neddylation R-HSA-8951664 8.517245e-01 0.070 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.542188e-01 0.068 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 8.542188e-01 0.068 0 0
Platelet calcium homeostasis R-HSA-418360 8.542188e-01 0.068 0 0
Termination of translesion DNA synthesis R-HSA-5656169 8.542188e-01 0.068 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 8.542188e-01 0.068 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.594767e-01 0.066 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.694256e-01 0.061 0 0
Trafficking of AMPA receptors R-HSA-399719 8.694256e-01 0.061 0 0
Selenoamino acid metabolism R-HSA-2408522 8.714446e-01 0.060 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 8.764240e-01 0.057 0 0
Signaling by WNT in cancer R-HSA-4791275 8.764240e-01 0.057 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 8.774871e-01 0.057 0 0
Activation of HOX genes during differentiation R-HSA-5619507 8.801654e-01 0.055 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 8.801654e-01 0.055 0 0
Peroxisomal protein import R-HSA-9033241 8.826811e-01 0.054 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 8.830477e-01 0.054 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 8.830477e-01 0.054 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.830477e-01 0.054 0 0
Cardiogenesis R-HSA-9733709 8.830477e-01 0.054 0 0
RAB geranylgeranylation R-HSA-8873719 8.876707e-01 0.052 0 0
tRNA Aminoacylation R-HSA-379724 8.876707e-01 0.052 0 0
CS/DS degradation R-HSA-2024101 8.893168e-01 0.051 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.893168e-01 0.051 0 0
Vpu mediated degradation of CD4 R-HSA-180534 8.893168e-01 0.051 0 0
Effects of PIP2 hydrolysis R-HSA-114508 8.893168e-01 0.051 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 8.893168e-01 0.051 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.924629e-01 0.049 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.924629e-01 0.049 0 0
Dual Incision in GG-NER R-HSA-5696400 8.952502e-01 0.048 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 8.952502e-01 0.048 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.952502e-01 0.048 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 8.952502e-01 0.048 0 0
Signal amplification R-HSA-392518 8.952502e-01 0.048 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.952502e-01 0.048 0 0
Hyaluronan metabolism R-HSA-2142845 8.952502e-01 0.048 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.952502e-01 0.048 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 8.954023e-01 0.048 0 0
Antigen processing-Cross presentation R-HSA-1236975 8.954023e-01 0.048 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.954023e-01 0.048 0 0
Gastrulation R-HSA-9758941 8.959219e-01 0.048 0 0
Cell surface interactions at the vascular wall R-HSA-202733 8.982182e-01 0.047 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.989352e-01 0.046 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 9.008658e-01 0.045 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.008658e-01 0.045 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.008658e-01 0.045 0 0
PERK regulates gene expression R-HSA-381042 9.008658e-01 0.045 0 0
Oncogene Induced Senescence R-HSA-2559585 9.008658e-01 0.045 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.008658e-01 0.045 0 0
Diseases of programmed cell death R-HSA-9645723 9.012886e-01 0.045 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.021287e-01 0.045 0 0
Reproduction R-HSA-1474165 9.027654e-01 0.044 0 0
Ion transport by P-type ATPases R-HSA-936837 9.057227e-01 0.043 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.061807e-01 0.043 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.061807e-01 0.043 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.061807e-01 0.043 0 0
Glycosphingolipid transport R-HSA-9845576 9.061807e-01 0.043 0 0
Downstream TCR signaling R-HSA-202424 9.085811e-01 0.042 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.089104e-01 0.041 0 0
Cellular response to hypoxia R-HSA-1234174 9.097919e-01 0.041 0 0
Voltage gated Potassium channels R-HSA-1296072 9.112110e-01 0.040 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.112110e-01 0.040 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.112110e-01 0.040 0 0
Degradation of DVL R-HSA-4641258 9.112110e-01 0.040 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.112110e-01 0.040 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.120358e-01 0.040 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.120358e-01 0.040 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.120412e-01 0.040 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.136961e-01 0.039 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.159719e-01 0.038 0 0
Kidney development R-HSA-9830369 9.174414e-01 0.037 0 0
Nicotinate metabolism R-HSA-196807 9.174414e-01 0.037 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.181462e-01 0.037 0 0
HCMV Late Events R-HSA-9610379 9.181462e-01 0.037 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.186067e-01 0.037 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 9.204777e-01 0.036 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 9.204777e-01 0.036 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.204777e-01 0.036 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.204777e-01 0.036 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.208465e-01 0.036 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 9.210335e-01 0.036 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.224694e-01 0.035 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.236027e-01 0.035 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.247220e-01 0.034 0 0
Attenuation phase R-HSA-3371568 9.247422e-01 0.034 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.247422e-01 0.034 0 0
Signaling by Hedgehog R-HSA-5358351 9.274089e-01 0.033 0 0
COPII-mediated vesicle transport R-HSA-204005 9.277806e-01 0.033 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 9.277806e-01 0.033 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.287783e-01 0.032 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.287783e-01 0.032 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.287783e-01 0.032 0 0
Maturation of spike protein R-HSA-9694548 9.287783e-01 0.032 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.287783e-01 0.032 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.313348e-01 0.031 0 0
Degradation of CRY and PER proteins R-HSA-9932298 9.325981e-01 0.030 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 9.325981e-01 0.030 0 0
Intra-Golgi traffic R-HSA-6811438 9.325981e-01 0.030 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.325981e-01 0.030 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 9.325981e-01 0.030 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 9.325981e-01 0.030 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.325981e-01 0.030 0 0
Translation of Structural Proteins R-HSA-9683701 9.325981e-01 0.030 0 0
Signaling by WNT R-HSA-195721 9.328269e-01 0.030 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.331088e-01 0.030 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.362133e-01 0.029 0 0
Ca2+ pathway R-HSA-4086398 9.368884e-01 0.028 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.384004e-01 0.028 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.396348e-01 0.027 0 0
Muscle contraction R-HSA-397014 9.398382e-01 0.027 0 0
Protein ubiquitination R-HSA-8852135 9.423432e-01 0.026 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.423432e-01 0.026 0 0
Proteasome assembly R-HSA-9907900 9.428729e-01 0.026 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.428729e-01 0.026 0 0
Surfactant metabolism R-HSA-5683826 9.428729e-01 0.026 0 0
Hedgehog 'off' state R-HSA-5610787 9.429540e-01 0.026 0 0
Interleukin-1 signaling R-HSA-9020702 9.451961e-01 0.024 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.459375e-01 0.024 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.459375e-01 0.024 0 0
DAG and IP3 signaling R-HSA-1489509 9.459375e-01 0.024 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.473479e-01 0.023 0 0
PI Metabolism R-HSA-1483255 9.473562e-01 0.023 0 0
Regulation of pyruvate metabolism R-HSA-9861718 9.488379e-01 0.023 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.494368e-01 0.023 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.496923e-01 0.022 0 0
Opioid Signalling R-HSA-111885 9.514406e-01 0.022 0 0
Synthesis of PC R-HSA-1483191 9.515829e-01 0.022 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 9.515829e-01 0.022 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.519369e-01 0.021 0 0
Sensory processing of sound R-HSA-9659379 9.519369e-01 0.021 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.535972e-01 0.021 0 0
Gluconeogenesis R-HSA-70263 9.541808e-01 0.020 0 0
Interleukin-1 family signaling R-HSA-446652 9.563459e-01 0.019 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.566394e-01 0.019 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.566394e-01 0.019 0 0
Platelet homeostasis R-HSA-418346 9.570162e-01 0.019 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.573766e-01 0.019 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.581108e-01 0.019 0 0
Azathioprine ADME R-HSA-9748787 9.589662e-01 0.018 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.600283e-01 0.018 0 0
PPARA activates gene expression R-HSA-1989781 9.606837e-01 0.017 0 0
HSF1-dependent transactivation R-HSA-3371571 9.611683e-01 0.017 0 0
Complex IV assembly R-HSA-9864848 9.611683e-01 0.017 0 0
Nucleotide biosynthesis R-HSA-8956320 9.652247e-01 0.015 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.652247e-01 0.015 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.688577e-01 0.014 0 0
G alpha (z) signalling events R-HSA-418597 9.688577e-01 0.014 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.696807e-01 0.013 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 9.705295e-01 0.013 0 0
Ion homeostasis R-HSA-5578775 9.705295e-01 0.013 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.705295e-01 0.013 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.709063e-01 0.013 0 0
Synthesis of PA R-HSA-1483166 9.721116e-01 0.012 0 0
Neurotransmitter release cycle R-HSA-112310 9.723968e-01 0.012 0 0
Leishmania phagocytosis R-HSA-9664417 9.729833e-01 0.012 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.729833e-01 0.012 0 0
Parasite infection R-HSA-9664407 9.729833e-01 0.012 0 0
Sialic acid metabolism R-HSA-4085001 9.750259e-01 0.011 0 0
Triglyceride metabolism R-HSA-8979227 9.750259e-01 0.011 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.760138e-01 0.011 0 0
Metabolism of polyamines R-HSA-351202 9.763668e-01 0.010 0 0
G alpha (s) signalling events R-HSA-418555 9.786324e-01 0.009 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.786324e-01 0.009 0 0
Phospholipid metabolism R-HSA-1483257 9.787418e-01 0.009 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.805519e-01 0.009 0 0
Mitochondrial translation elongation R-HSA-5389840 9.810472e-01 0.008 0 0
Potassium Channels R-HSA-1296071 9.810472e-01 0.008 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.810472e-01 0.008 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.810490e-01 0.008 0 0
Mitochondrial translation initiation R-HSA-5368286 9.827594e-01 0.008 0 0
Regulated Necrosis R-HSA-5218859 9.848044e-01 0.007 0 0
Extracellular matrix organization R-HSA-1474244 9.850730e-01 0.007 0 0
Metabolism of proteins R-HSA-392499 9.864023e-01 0.006 1 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.871244e-01 0.006 0 0
Hedgehog 'on' state R-HSA-5632684 9.871244e-01 0.006 0 0
RSV-host interactions R-HSA-9833110 9.876476e-01 0.005 0 0
Interferon gamma signaling R-HSA-877300 9.877312e-01 0.005 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 9.878163e-01 0.005 0 0
Aspirin ADME R-HSA-9749641 9.884710e-01 0.005 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.896769e-01 0.005 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.896769e-01 0.005 0 0
Stimuli-sensing channels R-HSA-2672351 9.898039e-01 0.004 0 0
Mitochondrial translation termination R-HSA-5419276 9.902827e-01 0.004 0 0
Mitochondrial translation R-HSA-5368287 9.910786e-01 0.004 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.914159e-01 0.004 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.916809e-01 0.004 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.917238e-01 0.004 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 9.921829e-01 0.003 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.933652e-01 0.003 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.933993e-01 0.003 0 0
Pyruvate metabolism R-HSA-70268 9.949674e-01 0.002 0 0
Neuronal System R-HSA-112316 9.955754e-01 0.002 0 0
Protein localization R-HSA-9609507 9.956200e-01 0.002 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.957367e-01 0.002 0 0
Formation of the cornified envelope R-HSA-6809371 9.957441e-01 0.002 0 0
Transmission across Chemical Synapses R-HSA-112315 9.960508e-01 0.002 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.963263e-01 0.002 0 0
FCGR activation R-HSA-2029481 9.965828e-01 0.001 0 0
Ion channel transport R-HSA-983712 9.966005e-01 0.001 0 0
Mitochondrial protein degradation R-HSA-9837999 9.967667e-01 0.001 0 0
Immune System R-HSA-168256 9.968200e-01 0.001 0 0
Regulation of insulin secretion R-HSA-422356 9.975480e-01 0.001 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.976800e-01 0.001 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.978470e-01 0.001 0 0
Integration of energy metabolism R-HSA-163685 9.979680e-01 0.001 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.983160e-01 0.001 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.983160e-01 0.001 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.983356e-01 0.001 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.987014e-01 0.001 0 0
Disease R-HSA-1643685 9.987218e-01 0.001 1 0
Infectious disease R-HSA-5663205 9.987455e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.988061e-01 0.001 0 0
Antimicrobial peptides R-HSA-6803157 9.988704e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.990380e-01 0.000 0 0
Leishmania infection R-HSA-9658195 9.991322e-01 0.000 0 0
Parasitic Infection Pathways R-HSA-9824443 9.991322e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.991963e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.992748e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.994190e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.995345e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.995442e-01 0.000 0 0
Cardiac conduction R-HSA-5576891 9.997013e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.997013e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.997174e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.998064e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.998364e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.998523e-01 0.000 0 0
Complement cascade R-HSA-166658 9.998771e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.998828e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.998913e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.998968e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 9.999369e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999498e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999640e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999814e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999842e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999868e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999909e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999922e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999976e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999983e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999986e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999993e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999996e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999997e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999999e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.999999e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Cell Cycle R-HSA-1640170 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 1.554312e-14 13.808 0 0
M Phase R-HSA-68886 9.747758e-14 13.011 0 0
HSF1-dependent transactivation R-HSA-3371571 3.802514e-13 12.420 0 0
Cell Cycle Checkpoints R-HSA-69620 3.929079e-13 12.406 0 0
G2/M Checkpoints R-HSA-69481 3.740341e-13 12.427 0 0
Cell Cycle, Mitotic R-HSA-69278 4.021228e-13 12.396 0 0
Cellular responses to stress R-HSA-2262752 5.703216e-13 12.244 0 0
Cell-Cell communication R-HSA-1500931 1.577849e-12 11.802 0 0
Metabolism of RNA R-HSA-8953854 2.791878e-12 11.554 0 0
Attenuation phase R-HSA-3371568 5.292544e-12 11.276 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.575452e-12 11.019 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.053524e-11 10.977 0 0
Cellular responses to stimuli R-HSA-8953897 1.213707e-11 10.916 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.123454e-10 9.949 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.123454e-10 9.949 0 0
DNA Double Strand Break Response R-HSA-5693606 1.818490e-10 9.740 0 0
DNA Double-Strand Break Repair R-HSA-5693532 2.933368e-10 9.533 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.363991e-10 9.360 0 0
Apoptotic execution phase R-HSA-75153 5.543422e-10 9.256 0 0
HSF1 activation R-HSA-3371511 6.006305e-10 9.221 0 0
Cell junction organization R-HSA-446728 8.138163e-10 9.089 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.036075e-09 8.985 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.593568e-09 8.798 0 0
Chromatin organization R-HSA-4839726 1.822127e-09 8.739 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 2.111093e-09 8.675 0 0
Mitotic Anaphase R-HSA-68882 5.079651e-09 8.294 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.915393e-09 8.228 0 0
Chromatin modifying enzymes R-HSA-3247509 5.823092e-09 8.235 0 0
Adherens junctions interactions R-HSA-418990 6.881050e-09 8.162 0 0
Homology Directed Repair R-HSA-5693538 9.619163e-09 8.017 0 0
Processing of DNA double-strand break ends R-HSA-5693607 1.119943e-08 7.951 0 0
Apoptosis R-HSA-109581 1.125959e-08 7.948 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.101910e-08 7.677 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.270043e-08 7.644 0 0
Cell-cell junction organization R-HSA-421270 2.778074e-08 7.556 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.051903e-08 7.515 0 0
Assembly of the pre-replicative complex R-HSA-68867 3.391340e-08 7.470 0 0
Separation of Sister Chromatids R-HSA-2467813 3.980787e-08 7.400 0 0
mRNA Splicing R-HSA-72172 5.923216e-08 7.227 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.121764e-08 7.213 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.332296e-08 7.198 0 0
Regulation of CDH1 Function R-HSA-9764561 9.259870e-08 7.033 0 0
Mitotic Prophase R-HSA-68875 1.110752e-07 6.954 0 0
Programmed Cell Death R-HSA-5357801 1.552215e-07 6.809 0 0
Ub-specific processing proteases R-HSA-5689880 1.929586e-07 6.715 1 1
DNA Replication Pre-Initiation R-HSA-69002 1.845328e-07 6.734 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 1.923978e-07 6.716 1 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.631919e-07 6.580 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 3.701674e-07 6.432 0 0
Deubiquitination R-HSA-5688426 4.482637e-07 6.348 1 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 7.364366e-07 6.133 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 7.178700e-07 6.144 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.968132e-07 6.099 0 0
Meiosis R-HSA-1500620 8.907846e-07 6.050 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 1.009487e-06 5.996 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 1.070501e-06 5.970 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.170966e-06 5.931 0 0
Meiotic synapsis R-HSA-1221632 1.325734e-06 5.878 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 1.325734e-06 5.878 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.596085e-06 5.797 0 0
DNA Repair R-HSA-73894 2.513675e-06 5.600 0 0
Protein ubiquitination R-HSA-8852135 2.624069e-06 5.581 0 0
DNA Replication R-HSA-69306 3.172264e-06 5.499 0 0
Interleukin-12 signaling R-HSA-9020591 3.254374e-06 5.488 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.045116e-06 5.393 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 4.740416e-06 5.324 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.662454e-06 5.247 0 0
Epigenetic regulation of gene expression R-HSA-212165 5.622688e-06 5.250 0 0
Cellular Senescence R-HSA-2559583 5.756141e-06 5.240 0 0
Regulation of signaling by CBL R-HSA-912631 6.669176e-06 5.176 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 7.303384e-06 5.136 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 9.253952e-06 5.034 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 9.625668e-06 5.017 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 9.548259e-06 5.020 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 9.398077e-06 5.027 0 0
Interleukin-12 family signaling R-HSA-447115 1.256591e-05 4.901 0 0
Mitotic Prometaphase R-HSA-68877 1.341000e-05 4.873 0 0
Nervous system development R-HSA-9675108 1.807178e-05 4.743 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 2.034850e-05 4.691 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.138696e-05 4.670 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.730277e-05 4.564 0 0
Meiotic recombination R-HSA-912446 2.802904e-05 4.552 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 3.130862e-05 4.504 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.281278e-05 4.484 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.341469e-05 4.476 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.725144e-05 4.429 0 0
Signaling by ALK in cancer R-HSA-9700206 3.725144e-05 4.429 0 0
RNA Polymerase I Transcription R-HSA-73864 3.755323e-05 4.425 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.814816e-05 4.419 0 0
S Phase R-HSA-69242 3.837701e-05 4.416 0 0
Switching of origins to a post-replicative state R-HSA-69052 3.971075e-05 4.401 0 0
Axon guidance R-HSA-422475 4.078626e-05 4.389 0 0
Nephrin family interactions R-HSA-373753 4.726474e-05 4.325 0 0
Aggrephagy R-HSA-9646399 4.996181e-05 4.301 0 0
Degradation of CDH1 R-HSA-9766229 5.459099e-05 4.263 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.937650e-05 4.226 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 6.219233e-05 4.206 0 0
Signaling by ERBB2 R-HSA-1227986 6.644446e-05 4.178 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.484192e-05 4.188 0 0
HDACs deacetylate histones R-HSA-3214815 6.796086e-05 4.168 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 6.889868e-05 4.162 0 0
Gene expression (Transcription) R-HSA-74160 7.135312e-05 4.147 0 0
SARS-CoV-1-host interactions R-HSA-9692914 7.524639e-05 4.124 0 0
Regulation of TP53 Activity R-HSA-5633007 7.851785e-05 4.105 0 0
EPH-Ephrin signaling R-HSA-2682334 8.833054e-05 4.054 0 0
Ephrin signaling R-HSA-3928664 9.940079e-05 4.003 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 9.780748e-05 4.010 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.054132e-04 3.977 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 1.067647e-04 3.972 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.127385e-04 3.948 0 0
Stabilization of p53 R-HSA-69541 1.273561e-04 3.895 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.341714e-04 3.872 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.491615e-04 3.826 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.648613e-04 3.783 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.662241e-04 3.779 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 1.900423e-04 3.721 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.977337e-04 3.704 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 2.044047e-04 3.690 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.085649e-04 3.681 0 0
Host Interactions of HIV factors R-HSA-162909 2.267074e-04 3.645 0 0
Selective autophagy R-HSA-9663891 2.338234e-04 3.631 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 2.527672e-04 3.597 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.596534e-04 3.586 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 2.655828e-04 3.576 0 0
TCF dependent signaling in response to WNT R-HSA-201681 2.672683e-04 3.573 0 0
DNA methylation R-HSA-5334118 2.860248e-04 3.544 0 0
HATs acetylate histones R-HSA-3214847 2.871568e-04 3.542 0 0
Orc1 removal from chromatin R-HSA-68949 2.988004e-04 3.525 0 0
ESR-mediated signaling R-HSA-8939211 3.397798e-04 3.469 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.422257e-04 3.466 0 0
Smooth Muscle Contraction R-HSA-445355 3.620265e-04 3.441 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.972660e-04 3.401 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 3.914155e-04 3.407 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.086357e-04 3.389 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.241773e-04 3.372 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 4.303697e-04 3.366 0 0
Synthesis of DNA R-HSA-69239 4.315370e-04 3.365 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.365392e-04 3.360 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 4.443489e-04 3.352 1 1
Cell-extracellular matrix interactions R-HSA-446353 4.443489e-04 3.352 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 4.471870e-04 3.350 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.787335e-04 3.320 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 4.940804e-04 3.306 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 4.620978e-04 3.335 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 4.620978e-04 3.335 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.548841e-04 3.342 0 0
Signaling by ROBO receptors R-HSA-376176 5.160370e-04 3.287 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.372761e-04 3.270 0 0
Packaging Of Telomere Ends R-HSA-171306 5.785717e-04 3.238 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 5.785717e-04 3.238 0 0
Reproduction R-HSA-1474165 5.806602e-04 3.236 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.889545e-04 3.230 0 0
Nucleosome assembly R-HSA-774815 5.889545e-04 3.230 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 6.103742e-04 3.214 0 0
Regulation of TP53 Degradation R-HSA-6804757 6.192248e-04 3.208 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 6.260756e-04 3.203 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 6.343222e-04 3.198 0 0
Co-inhibition by PD-1 R-HSA-389948 7.108689e-04 3.148 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.824824e-04 3.166 0 0
G2/M Transition R-HSA-69275 6.611188e-04 3.180 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 7.152868e-04 3.146 0 0
Mitotic Spindle Checkpoint R-HSA-69618 7.211662e-04 3.142 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 7.282723e-04 3.138 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 7.361323e-04 3.133 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 7.540161e-04 3.123 0 0
Signaling by NOTCH R-HSA-157118 7.582850e-04 3.120 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 7.700046e-04 3.114 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 7.716433e-04 3.113 0 0
HIV Infection R-HSA-162906 7.906146e-04 3.102 0 0
Mitotic G2-G2/M phases R-HSA-453274 7.925108e-04 3.101 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.040395e-04 3.095 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 8.063273e-04 3.093 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 8.063273e-04 3.093 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.015793e-04 3.045 0 0
Late endosomal microautophagy R-HSA-9615710 9.542346e-04 3.020 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 8.640235e-04 3.063 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.615300e-04 3.017 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.615300e-04 3.017 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 8.824610e-04 3.054 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 9.053925e-04 3.043 0 0
Striated Muscle Contraction R-HSA-390522 9.670927e-04 3.015 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 9.908790e-04 3.004 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 9.908790e-04 3.004 0 0
Cytokine Signaling in Immune system R-HSA-1280215 1.052677e-03 2.978 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.057952e-03 2.976 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.108333e-03 2.955 1 1
Defective pyroptosis R-HSA-9710421 1.108333e-03 2.955 0 0
Translation initiation complex formation R-HSA-72649 1.141454e-03 2.943 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.165750e-03 2.933 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 1.167638e-03 2.933 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 1.167638e-03 2.933 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.336435e-03 2.874 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 1.349157e-03 2.870 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.353295e-03 2.869 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.379084e-03 2.860 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 1.407461e-03 2.852 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 1.483449e-03 2.829 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.602694e-03 2.795 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 1.587944e-03 2.799 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.577783e-03 2.802 0 0
Ribosome-associated quality control R-HSA-9948299 1.494912e-03 2.825 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.577783e-03 2.802 0 0
Regulation of Apoptosis R-HSA-169911 1.483449e-03 2.829 0 0
Autophagy R-HSA-9612973 1.425802e-03 2.846 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.414561e-03 2.849 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 1.420173e-03 2.848 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.455715e-03 2.837 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.646786e-03 2.783 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.659161e-03 2.780 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.671185e-03 2.777 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.719338e-03 2.765 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.719338e-03 2.765 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.719338e-03 2.765 0 0
PKR-mediated signaling R-HSA-9833482 1.782814e-03 2.749 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.783796e-03 2.749 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.783796e-03 2.749 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 1.830023e-03 2.738 1 1
Nuclear Envelope Breakdown R-HSA-2980766 1.861380e-03 2.730 0 0
Gene Silencing by RNA R-HSA-211000 1.873952e-03 2.727 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 1.881688e-03 2.725 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 1.888797e-03 2.724 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 1.888797e-03 2.724 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 1.888797e-03 2.724 0 0
Signaling downstream of RAS mutants R-HSA-9649948 1.911914e-03 2.719 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.911914e-03 2.719 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 1.911914e-03 2.719 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 1.911914e-03 2.719 0 0
Signaling by RAS mutants R-HSA-6802949 1.911914e-03 2.719 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.942306e-03 2.712 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.942306e-03 2.712 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 1.946150e-03 2.711 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.946150e-03 2.711 0 0
Signaling by RAF1 mutants R-HSA-9656223 2.069093e-03 2.684 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 2.062164e-03 2.686 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 2.025084e-03 2.694 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 2.093823e-03 2.679 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.319778e-03 2.635 0 0
Telomere Maintenance R-HSA-157579 2.212490e-03 2.655 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.027126e-03 2.693 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 2.210168e-03 2.656 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.212490e-03 2.655 1 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.319778e-03 2.635 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.335368e-03 2.632 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.475737e-03 2.606 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.571895e-03 2.590 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 2.591498e-03 2.586 0 0
TCR signaling R-HSA-202403 2.600264e-03 2.585 0 0
Regulation of mitotic cell cycle R-HSA-453276 2.632170e-03 2.580 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 2.632170e-03 2.580 0 0
Chromosome Maintenance R-HSA-73886 2.659734e-03 2.575 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 2.659734e-03 2.575 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.837688e-03 2.547 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.837688e-03 2.547 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 2.946019e-03 2.531 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 2.952707e-03 2.530 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.952707e-03 2.530 0 0
AURKA Activation by TPX2 R-HSA-8854518 2.986981e-03 2.525 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.059404e-03 2.514 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 3.206792e-03 2.494 0 0
rRNA processing R-HSA-72312 3.270375e-03 2.485 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.425211e-03 2.465 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 3.430737e-03 2.465 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 3.430737e-03 2.465 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.445659e-03 2.463 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 3.445659e-03 2.463 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 3.462918e-03 2.461 0 0
Influenza Infection R-HSA-168255 3.562767e-03 2.448 0 0
Interferon Signaling R-HSA-913531 3.628305e-03 2.440 0 0
Macroautophagy R-HSA-1632852 3.665398e-03 2.436 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.705276e-03 2.431 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.705276e-03 2.431 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 3.705276e-03 2.431 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.221936e-03 2.374 0 0
Pexophagy R-HSA-9664873 4.379052e-03 2.359 0 0
Josephin domain DUBs R-HSA-5689877 4.379052e-03 2.359 0 0
Nef and signal transduction R-HSA-164944 4.221936e-03 2.374 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.827328e-03 2.417 0 0
Signaling by VEGF R-HSA-194138 4.318733e-03 2.365 0 0
Semaphorin interactions R-HSA-373755 4.462148e-03 2.350 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 4.154580e-03 2.381 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 4.462148e-03 2.350 0 0
RNA Polymerase II Transcription R-HSA-73857 3.859564e-03 2.413 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 4.006306e-03 2.397 0 0
Death Receptor Signaling R-HSA-73887 3.879804e-03 2.411 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.827328e-03 2.417 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.006306e-03 2.397 0 0
Hedgehog ligand biogenesis R-HSA-5358346 4.296645e-03 2.367 0 0
Signaling by NOTCH4 R-HSA-9013694 3.899990e-03 2.409 0 0
Signaling by Interleukins R-HSA-449147 4.166056e-03 2.380 0 0
Signal Transduction R-HSA-162582 4.492485e-03 2.348 1 0
Signaling by Hippo R-HSA-2028269 4.537575e-03 2.343 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 4.541596e-03 2.343 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.648028e-03 2.333 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 4.710239e-03 2.327 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.894046e-03 2.310 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 4.975948e-03 2.303 0 0
HIV Life Cycle R-HSA-162587 4.976750e-03 2.303 0 0
UCH proteinases R-HSA-5689603 4.998600e-03 2.301 1 1
Diseases of programmed cell death R-HSA-9645723 5.330994e-03 2.273 0 0
Degradation of CRY and PER proteins R-HSA-9932298 5.359392e-03 2.271 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 5.359392e-03 2.271 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.359392e-03 2.271 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 5.359392e-03 2.271 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.424064e-03 2.266 0 0
Interaction between L1 and Ankyrins R-HSA-445095 5.718499e-03 2.243 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 5.915195e-03 2.228 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 5.921819e-03 2.228 0 0
Degradation of DVL R-HSA-4641258 5.921819e-03 2.228 0 0
Degradation of AXIN R-HSA-4641257 5.921819e-03 2.228 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 5.921819e-03 2.228 0 0
Cleavage of the damaged purine R-HSA-110331 5.921819e-03 2.228 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.157277e-03 2.211 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 6.210121e-03 2.207 0 0
PECAM1 interactions R-HSA-210990 6.210121e-03 2.207 0 0
Activation of ATR in response to replication stress R-HSA-176187 6.473996e-03 2.189 0 0
Regulation of PTEN localization R-HSA-8948747 6.515193e-03 2.186 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 6.631030e-03 2.178 0 0
Oncogenic MAPK signaling R-HSA-6802957 6.882402e-03 2.162 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 6.882402e-03 2.162 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 7.004747e-03 2.155 0 0
Depurination R-HSA-73927 7.004747e-03 2.155 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 7.057965e-03 2.151 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 7.187879e-03 2.143 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 7.187879e-03 2.143 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 7.187879e-03 2.143 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 7.312972e-03 2.136 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 8.542833e-03 2.068 0 0
Negative regulation of FLT3 R-HSA-9706369 9.344112e-03 2.029 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 7.476786e-03 2.126 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 9.170942e-03 2.038 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 9.170942e-03 2.038 0 0
Dual Incision in GG-NER R-HSA-5696400 9.170942e-03 2.038 0 0
Centrosome maturation R-HSA-380287 9.210496e-03 2.036 0 0
DNA Damage Bypass R-HSA-73893 7.535804e-03 2.123 0 0
Translesion Synthesis by POLH R-HSA-110320 7.476786e-03 2.126 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 8.538259e-03 2.069 0 0
NF-kB is activated and signals survival R-HSA-209560 8.542833e-03 2.068 0 0
Nuclear import of Rev protein R-HSA-180746 9.170942e-03 2.038 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 7.776661e-03 2.109 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 9.344112e-03 2.029 0 0
Membrane Trafficking R-HSA-199991 7.723426e-03 2.112 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 8.542833e-03 2.068 0 0
G1/S Transition R-HSA-69206 7.844593e-03 2.105 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.237718e-03 2.084 0 0
Negative regulation of MET activity R-HSA-6807004 9.396326e-03 2.027 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 9.396326e-03 2.027 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 9.564317e-03 2.019 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 9.634077e-03 2.016 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 9.634077e-03 2.016 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.876279e-03 2.005 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 9.876279e-03 2.005 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.876279e-03 2.005 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.876279e-03 2.005 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.947027e-03 2.002 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.010802e-02 1.995 0 0
Activation of BH3-only proteins R-HSA-114452 1.010802e-02 1.995 0 0
L1CAM interactions R-HSA-373760 1.053701e-02 1.977 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 1.080900e-02 1.966 0 0
Nucleotide Excision Repair R-HSA-5696398 1.086261e-02 1.964 0 0
Long-term potentiation R-HSA-9620244 1.097897e-02 1.959 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.120744e-02 1.950 0 0
FLT3 Signaling R-HSA-9607240 1.120744e-02 1.950 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 1.120744e-02 1.950 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.154245e-02 1.938 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.154245e-02 1.938 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.154245e-02 1.938 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.154245e-02 1.938 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.154245e-02 1.938 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.154245e-02 1.938 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.154245e-02 1.938 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.154245e-02 1.938 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.154245e-02 1.938 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.154245e-02 1.938 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 1.154245e-02 1.938 1 1
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.154245e-02 1.938 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 1.193883e-02 1.923 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.203060e-02 1.920 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.203060e-02 1.920 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.229027e-02 1.910 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.292543e-02 1.889 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.323495e-02 1.878 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.332584e-02 1.875 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.332584e-02 1.875 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.347403e-02 1.871 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 1.347403e-02 1.871 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 1.430291e-02 1.845 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.430291e-02 1.845 0 0
Muscle contraction R-HSA-397014 1.431456e-02 1.844 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.447280e-02 1.839 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.447280e-02 1.839 0 0
Maturation of protein E R-HSA-9694493 1.447280e-02 1.839 0 0
Maturation of protein E R-HSA-9683683 1.447280e-02 1.839 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.465398e-02 1.834 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 1.474702e-02 1.831 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.494053e-02 1.826 0 0
Depyrimidination R-HSA-73928 1.494053e-02 1.826 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.498074e-02 1.824 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.498074e-02 1.824 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.568380e-02 1.805 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.570143e-02 1.804 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 1.581754e-02 1.801 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.581754e-02 1.801 0 0
PTEN Regulation R-HSA-6807070 1.632585e-02 1.787 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.634933e-02 1.787 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.647177e-02 1.783 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.668682e-02 1.778 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.668682e-02 1.778 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 1.668682e-02 1.778 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 2.073046e-02 1.683 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 1.946070e-02 1.711 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 2.255784e-02 1.647 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.967825e-02 1.706 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.255710e-02 1.647 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.919008e-02 1.717 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.703910e-02 1.769 0 0
HCMV Early Events R-HSA-9609690 1.895391e-02 1.722 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.833789e-02 1.737 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 2.128660e-02 1.672 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.708025e-02 1.768 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.255784e-02 1.647 0 0
Mitophagy R-HSA-5205647 2.255784e-02 1.647 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.172556e-02 1.663 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 1.875173e-02 1.727 0 0
ER-Phagosome pathway R-HSA-1236974 2.172030e-02 1.663 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.921063e-02 1.716 0 0
NRIF signals cell death from the nucleus R-HSA-205043 1.921063e-02 1.716 0 0
Generic Transcription Pathway R-HSA-212436 2.064037e-02 1.685 0 0
Regulation of KIT signaling R-HSA-1433559 1.921063e-02 1.716 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.954799e-02 1.709 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 2.007782e-02 1.697 0 0
Signaling by PTK6 R-HSA-8848021 2.007782e-02 1.697 0 0
ABC-family proteins mediated transport R-HSA-382556 2.085464e-02 1.681 0 0
Interleukin-1 signaling R-HSA-9020702 2.268330e-02 1.644 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.946070e-02 1.711 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 2.163795e-02 1.665 0 0
Amyloid fiber formation R-HSA-977225 1.734805e-02 1.761 0 0
Glycolysis R-HSA-70171 2.085464e-02 1.681 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.862144e-02 1.730 0 0
Diseases of Telomere Maintenance R-HSA-9673013 2.274115e-02 1.643 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 2.274115e-02 1.643 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 2.274115e-02 1.643 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.274115e-02 1.643 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 2.274115e-02 1.643 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 2.274115e-02 1.643 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.279260e-02 1.642 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.279260e-02 1.642 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 2.418879e-02 1.616 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.418879e-02 1.616 0 0
Translesion synthesis by REV1 R-HSA-110312 2.418879e-02 1.616 0 0
Protein methylation R-HSA-8876725 2.418879e-02 1.616 0 0
p75NTR signals via NF-kB R-HSA-193639 2.418879e-02 1.616 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 2.423576e-02 1.616 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.481687e-02 1.605 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 2.481687e-02 1.605 0 0
Cellular response to hypoxia R-HSA-1234174 2.482374e-02 1.605 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 2.513923e-02 1.600 0 0
Diseases of DNA repair R-HSA-9675135 2.513923e-02 1.600 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 2.577049e-02 1.589 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 2.577049e-02 1.589 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.599700e-02 1.585 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 2.599700e-02 1.585 0 0
Signaling by WNT R-HSA-195721 2.741836e-02 1.562 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.756735e-02 1.560 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 2.756735e-02 1.560 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 2.756735e-02 1.560 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 2.756735e-02 1.560 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 2.756735e-02 1.560 0 0
Signaling by TGFB family members R-HSA-9006936 2.782154e-02 1.556 1 0
Recycling pathway of L1 R-HSA-437239 2.833672e-02 1.548 0 0
Viral Infection Pathways R-HSA-9824446 2.876424e-02 1.541 0 0
MAP2K and MAPK activation R-HSA-5674135 2.921929e-02 1.534 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 2.921929e-02 1.534 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.928217e-02 1.533 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 2.960551e-02 1.529 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 2.960551e-02 1.529 0 0
Recycling of eIF2:GDP R-HSA-72731 2.960551e-02 1.529 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 2.960551e-02 1.529 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.960551e-02 1.529 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 2.979601e-02 1.526 0 0
RNA Polymerase III Transcription R-HSA-74158 2.979601e-02 1.526 0 0
EGFR downregulation R-HSA-182971 2.989991e-02 1.524 0 0
Translesion synthesis by POLI R-HSA-5656121 2.996261e-02 1.523 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 2.998846e-02 1.523 0 0
Translation R-HSA-72766 3.005864e-02 1.522 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 3.123216e-02 1.505 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 3.127541e-02 1.505 0 0
Post NMDA receptor activation events R-HSA-438064 3.288550e-02 1.483 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 3.295850e-02 1.482 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 3.295850e-02 1.482 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 3.297865e-02 1.482 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.303194e-02 1.481 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 3.388759e-02 1.470 0 0
Signaling by NOTCH3 R-HSA-9012852 3.388759e-02 1.470 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.397164e-02 1.469 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.427160e-02 1.465 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 3.446065e-02 1.463 0 0
G0 and Early G1 R-HSA-1538133 3.447010e-02 1.463 0 0
Translesion synthesis by POLK R-HSA-5655862 3.657176e-02 1.437 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.657176e-02 1.437 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 3.760195e-02 1.425 0 0
Signaling by EGFR R-HSA-177929 3.760195e-02 1.425 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.760195e-02 1.425 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.905503e-02 1.408 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 3.905503e-02 1.408 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.937523e-02 1.405 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.937523e-02 1.405 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 3.937523e-02 1.405 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 3.937523e-02 1.405 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 3.949938e-02 1.403 0 0
Regulation of RAS by GAPs R-HSA-5658442 3.968326e-02 1.401 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.970138e-02 1.401 0 0
Modulation by Mtb of host immune system R-HSA-9637628 3.970138e-02 1.401 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.980744e-02 1.400 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.029230e-02 1.395 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 4.060886e-02 1.391 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 4.159668e-02 1.381 0 0
Proteasome assembly R-HSA-9907900 4.168744e-02 1.380 0 0
Base Excision Repair R-HSA-73884 4.202627e-02 1.376 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.218085e-02 1.375 0 0
Hedgehog 'on' state R-HSA-5632684 4.406678e-02 1.356 0 0
mTORC1-mediated signalling R-HSA-166208 4.582013e-02 1.339 0 0
Dual incision in TC-NER R-HSA-6782135 4.588054e-02 1.338 0 0
Manipulation of host energy metabolism R-HSA-9636667 4.748130e-02 1.323 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.817932e-02 1.317 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 4.817932e-02 1.317 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.817932e-02 1.317 1 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.869631e-02 1.313 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.869631e-02 1.313 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.329247e-02 1.273 0 0
Termination of translesion DNA synthesis R-HSA-5656169 5.259205e-02 1.279 0 0
Activation of the pre-replicative complex R-HSA-68962 5.986925e-02 1.223 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.774940e-02 1.169 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.890652e-02 1.311 0 0
Generation of second messenger molecules R-HSA-202433 4.890652e-02 1.311 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 4.655413e-02 1.332 0 0
mRNA 3'-end processing R-HSA-72187 4.881810e-02 1.311 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.769973e-02 1.169 0 0
Signaling by ERBB4 R-HSA-1236394 5.687528e-02 1.245 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 4.905919e-02 1.309 0 0
Peptide chain elongation R-HSA-156902 6.151001e-02 1.211 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 6.554682e-02 1.183 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.896954e-02 1.310 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.472940e-02 1.262 0 0
PERK regulates gene expression R-HSA-381042 5.749356e-02 1.240 0 0
GP1b-IX-V activation signalling R-HSA-430116 5.152384e-02 1.288 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 5.259205e-02 1.279 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.505704e-02 1.187 0 0
FLT3 signaling in disease R-HSA-9682385 6.449938e-02 1.190 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 5.152384e-02 1.288 0 0
Regulation of CDH11 function R-HSA-9762292 6.505704e-02 1.187 0 0
Clathrin-mediated endocytosis R-HSA-8856828 5.744619e-02 1.241 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 6.821325e-02 1.166 0 0
MTOR signalling R-HSA-165159 6.769973e-02 1.169 0 0
GPVI-mediated activation cascade R-HSA-114604 6.449938e-02 1.190 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 5.259205e-02 1.279 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 5.741628e-02 1.241 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.748130e-02 1.323 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.655413e-02 1.332 0 0
HCMV Infection R-HSA-9609646 6.781814e-02 1.169 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 6.624172e-02 1.179 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.872951e-02 1.312 0 0
Kinesins R-HSA-983189 5.534715e-02 1.257 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.534715e-02 1.257 0 0
Unwinding of DNA R-HSA-176974 5.152384e-02 1.288 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 6.925789e-02 1.160 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.519411e-02 1.186 0 0
Hedgehog 'off' state R-HSA-5610787 6.055448e-02 1.218 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.821325e-02 1.166 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.921008e-02 1.228 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 6.054372e-02 1.218 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.505704e-02 1.187 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 6.129713e-02 1.213 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 5.241272e-02 1.281 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 5.472940e-02 1.262 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 5.929509e-02 1.227 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.972485e-02 1.157 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 7.040600e-02 1.152 0 0
HDMs demethylate histones R-HSA-3214842 7.040600e-02 1.152 0 0
Spry regulation of FGF signaling R-HSA-1295596 7.091516e-02 1.149 0 0
Downstream TCR signaling R-HSA-202424 7.099698e-02 1.149 0 0
ER to Golgi Anterograde Transport R-HSA-199977 7.164887e-02 1.145 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 7.185704e-02 1.144 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 7.202234e-02 1.143 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.506227e-02 1.125 0 0
Cellular response to chemical stress R-HSA-9711123 7.528570e-02 1.123 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.608884e-02 1.119 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 7.608884e-02 1.119 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.608884e-02 1.119 0 0
DNA strand elongation R-HSA-69190 7.623771e-02 1.118 0 0
Diseases of mitotic cell cycle R-HSA-9675126 7.623771e-02 1.118 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 7.623771e-02 1.118 0 0
PCP/CE pathway R-HSA-4086400 7.761503e-02 1.110 0 0
ABC transporter disorders R-HSA-5619084 7.761503e-02 1.110 0 0
MAPK family signaling cascades R-HSA-5683057 7.788592e-02 1.109 0 0
Regulation of TP53 Expression R-HSA-6804754 7.838973e-02 1.106 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 7.838973e-02 1.106 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 7.838973e-02 1.106 1 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 7.838973e-02 1.106 1 1
C-type lectin receptors (CLRs) R-HSA-5621481 8.110512e-02 1.091 0 0
IRE1alpha activates chaperones R-HSA-381070 8.141650e-02 1.089 0 0
RMTs methylate histone arginines R-HSA-3214858 8.247550e-02 1.084 0 0
SARS-CoV Infections R-HSA-9679506 8.279436e-02 1.082 0 0
Basigin interactions R-HSA-210991 8.293728e-02 1.081 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 8.379496e-02 1.077 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 8.379496e-02 1.077 0 0
Glucose metabolism R-HSA-70326 8.525862e-02 1.069 0 0
Regulation of necroptotic cell death R-HSA-5675482 8.533564e-02 1.069 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 8.692215e-02 1.061 1 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.720190e-02 1.059 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.720190e-02 1.059 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.838505e-02 1.054 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.863317e-02 1.052 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 9.043518e-02 1.044 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 9.147410e-02 1.039 0 0
snRNP Assembly R-HSA-191859 9.168095e-02 1.038 0 0
Metabolism of non-coding RNA R-HSA-194441 9.168095e-02 1.038 0 0
RAF/MAP kinase cascade R-HSA-5673001 9.238047e-02 1.034 0 0
Interleukin-1 family signaling R-HSA-446652 9.258537e-02 1.033 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.338755e-02 1.030 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 9.490946e-02 1.023 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.490946e-02 1.023 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 9.490946e-02 1.023 0 0
Assembly Of The HIV Virion R-HSA-175474 9.490946e-02 1.023 0 0
Activation of RAC1 R-HSA-428540 9.703817e-02 1.013 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 9.781895e-02 1.010 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 9.781895e-02 1.010 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 9.781895e-02 1.010 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 9.781895e-02 1.010 0 0
Regulation of TNFR1 signaling R-HSA-5357905 9.907637e-02 1.004 0 0
Neutrophil degranulation R-HSA-6798695 9.907845e-02 1.004 0 0
Calnexin/calreticulin cycle R-HSA-901042 1.053479e-01 0.977 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.071741e-01 0.970 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.071741e-01 0.970 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.073264e-01 0.969 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 1.077535e-01 0.968 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 1.077535e-01 0.968 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 1.077535e-01 0.968 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.080586e-01 0.966 0 0
Drug resistance of FLT3 mutants R-HSA-9702506 1.087010e-01 0.964 0 0
FLT3 mutants bind TKIs R-HSA-9702509 1.087010e-01 0.964 0 0
sorafenib-resistant FLT3 mutants R-HSA-9702624 1.087010e-01 0.964 0 0
midostaurin-resistant FLT3 mutants R-HSA-9702600 1.087010e-01 0.964 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.087010e-01 0.964 0 0
ponatinib-resistant FLT3 mutants R-HSA-9702614 1.087010e-01 0.964 0 0
quizartinib-resistant FLT3 mutants R-HSA-9702620 1.087010e-01 0.964 0 0
semaxanib-resistant FLT3 mutants R-HSA-9702577 1.087010e-01 0.964 0 0
Loss of function of TP53 in cancer due to loss of tetramerization ability R-HSA-9723905 1.087010e-01 0.964 0 0
lestaurtinib-resistant FLT3 mutants R-HSA-9702596 1.087010e-01 0.964 0 0
crenolanib-resistant FLT3 mutants R-HSA-9702581 1.087010e-01 0.964 0 0
linifanib-resistant FLT3 mutants R-HSA-9702998 1.087010e-01 0.964 0 0
gilteritinib-resistant FLT3 mutants R-HSA-9702590 1.087010e-01 0.964 0 0
tandutinib-resistant FLT3 mutants R-HSA-9702636 1.087010e-01 0.964 0 0
pexidartinib-resistant FLT3 mutants R-HSA-9702605 1.087010e-01 0.964 0 0
sunitinib-resistant FLT3 mutants R-HSA-9702632 1.087010e-01 0.964 0 0
tamatinib-resistant FLT3 mutants R-HSA-9703009 1.087010e-01 0.964 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.087010e-01 0.964 0 0
Loss of Function of TP53 in Cancer R-HSA-9723907 1.087010e-01 0.964 0 0
KW2449-resistant FLT3 mutants R-HSA-9702569 1.087010e-01 0.964 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 1.099498e-01 0.959 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 1.099498e-01 0.959 1 1
Eukaryotic Translation Termination R-HSA-72764 1.116459e-01 0.952 0 0
Signaling by NOTCH1 R-HSA-1980143 1.118507e-01 0.951 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 1.129439e-01 0.947 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 1.129439e-01 0.947 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 1.129439e-01 0.947 0 0
Glycogen storage diseases R-HSA-3229121 1.129439e-01 0.947 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 1.133334e-01 0.946 0 0
TRKA activation by NGF R-HSA-187042 1.138345e-01 0.944 0 0
PLC-gamma1 signalling R-HSA-167021 1.138345e-01 0.944 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.138345e-01 0.944 0 0
Axonal growth stimulation R-HSA-209563 1.138345e-01 0.944 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 1.138345e-01 0.944 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.153143e-01 0.938 0 0
Repression of WNT target genes R-HSA-4641265 1.153143e-01 0.938 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 1.153143e-01 0.938 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 1.153143e-01 0.938 0 0
VLDLR internalisation and degradation R-HSA-8866427 1.153143e-01 0.938 0 0
IRAK1 recruits IKK complex R-HSA-937039 1.153143e-01 0.938 0 0
tRNA processing in the nucleus R-HSA-6784531 1.154641e-01 0.938 0 0
Co-stimulation by CD28 R-HSA-389356 1.174899e-01 0.930 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 1.178186e-01 0.929 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 1.214420e-01 0.916 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.258214e-01 0.900 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 1.259743e-01 0.900 0 0
NRAGE signals death through JNK R-HSA-193648 1.259743e-01 0.900 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 1.259743e-01 0.900 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.273638e-01 0.895 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 1.273638e-01 0.895 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 1.289016e-01 0.890 0 0
Activation of HOX genes during differentiation R-HSA-5619507 1.289016e-01 0.890 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.291157e-01 0.889 0 0
Signaling by Nuclear Receptors R-HSA-9006931 1.298856e-01 0.886 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 1.303867e-01 0.885 0 0
Signaling by Hedgehog R-HSA-5358351 1.348193e-01 0.870 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.349669e-01 0.870 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 1.350263e-01 0.870 0 0
Sensory processing of sound R-HSA-9659379 1.357638e-01 0.867 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.359409e-01 0.867 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 2.055917e-01 0.687 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 2.055917e-01 0.687 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 2.055917e-01 0.687 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 2.055917e-01 0.687 0 0
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198 2.055917e-01 0.687 0 0
TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3642279 2.055917e-01 0.687 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 2.055917e-01 0.687 0 0
SARS-CoV-1 targets PDZ proteins in cell-cell junction R-HSA-9692912 2.055917e-01 0.687 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 2.055917e-01 0.687 0 0
Impaired BRCA2 translocation to the nucleus R-HSA-9709275 2.055917e-01 0.687 0 0
Hereditary fructose intolerance R-HSA-5657560 2.055917e-01 0.687 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 2.055917e-01 0.687 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 2.055917e-01 0.687 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.524654e-01 0.817 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.524654e-01 0.817 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.524654e-01 0.817 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.524654e-01 0.817 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.524654e-01 0.817 1 1
SMAC (DIABLO) binds to IAPs R-HSA-111463 1.931718e-01 0.714 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 1.931718e-01 0.714 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 1.931718e-01 0.714 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.931718e-01 0.714 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 1.931718e-01 0.714 1 1
ARMS-mediated activation R-HSA-170984 1.618408e-01 0.791 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 1.618408e-01 0.791 0 0
ALK mutants bind TKIs R-HSA-9700645 1.618408e-01 0.791 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.350466e-01 0.629 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 2.350466e-01 0.629 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 2.350466e-01 0.629 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 1.900818e-01 0.721 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.900818e-01 0.721 0 0
PI3K/AKT activation R-HSA-198203 1.900818e-01 0.721 0 0
2-LTR circle formation R-HSA-164843 1.900818e-01 0.721 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.900818e-01 0.721 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.558676e-01 0.807 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.778786e-01 0.750 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.643362e-01 0.784 0 0
Phosphorylation of the APC/C R-HSA-176412 2.008563e-01 0.697 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.008563e-01 0.697 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 2.496417e-01 0.603 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 2.496417e-01 0.603 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.496417e-01 0.603 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.496417e-01 0.603 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.832351e-01 0.737 0 0
Disorders of Developmental Biology R-HSA-9675151 2.246542e-01 0.648 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.246542e-01 0.648 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.838728e-01 0.735 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.491260e-01 0.604 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 2.011628e-01 0.696 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.821204e-01 0.740 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.741275e-01 0.562 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.741275e-01 0.562 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 1.976201e-01 0.704 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 1.595482e-01 0.797 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 1.752828e-01 0.756 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.752828e-01 0.756 0 0
DAP12 signaling R-HSA-2424491 2.373773e-01 0.625 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 1.710906e-01 0.767 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.710906e-01 0.767 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 1.508681e-01 0.821 0 0
Protein folding R-HSA-391251 2.041228e-01 0.690 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.225224e-01 0.653 0 0
Viral mRNA Translation R-HSA-192823 2.463391e-01 0.608 0 0
Signaling by NOTCH2 R-HSA-1980145 1.976201e-01 0.704 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 1.370934e-01 0.863 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 1.370934e-01 0.863 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 1.370934e-01 0.863 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.741275e-01 0.562 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 2.350466e-01 0.629 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.491260e-01 0.604 0 0
Prolonged ERK activation events R-HSA-169893 2.008563e-01 0.697 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 2.496417e-01 0.603 0 0
Integration of provirus R-HSA-162592 2.496417e-01 0.603 0 0
DCC mediated attractive signaling R-HSA-418885 1.778786e-01 0.750 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 1.778786e-01 0.750 0 0
Metalloprotease DUBs R-HSA-5689901 1.672039e-01 0.777 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 1.576583e-01 0.802 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.231964e-01 0.651 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 1.558676e-01 0.807 0 0
Nuclear RNA decay R-HSA-9930044 1.671551e-01 0.777 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.391651e-01 0.856 0 0
Myogenesis R-HSA-525793 1.672039e-01 0.777 0 0
Mismatch Repair R-HSA-5358508 2.741275e-01 0.562 0 0
p75NTR regulates axonogenesis R-HSA-193697 1.618408e-01 0.791 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.246542e-01 0.648 0 0
Budding and maturation of HIV virion R-HSA-162588 1.389731e-01 0.857 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.666833e-01 0.778 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.666833e-01 0.778 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.666833e-01 0.778 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.666833e-01 0.778 0 0
Cellular response to starvation R-HSA-9711097 2.286672e-01 0.641 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.821204e-01 0.740 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.136144e-01 0.670 0 0
Resolution of D-Loop Structures R-HSA-5693537 1.821204e-01 0.740 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 1.699982e-01 0.770 0 0
Activation and oligomerization of BAK protein R-HSA-111452 2.055917e-01 0.687 0 0
NADE modulates death signalling R-HSA-205025 1.524654e-01 0.817 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.931718e-01 0.714 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.832351e-01 0.737 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 1.671551e-01 0.777 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.373773e-01 0.625 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.821204e-01 0.740 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.783886e-01 0.749 0 0
Co-inhibition by CTLA4 R-HSA-389513 1.643362e-01 0.784 0 0
Post-translational protein modification R-HSA-597592 1.409256e-01 0.851 1 0
Signaling by SCF-KIT R-HSA-1433557 1.391678e-01 0.856 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.008563e-01 0.697 0 0
Vesicle-mediated transport R-HSA-5653656 1.688153e-01 0.773 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.741275e-01 0.562 0 0
Platelet degranulation R-HSA-114608 1.506736e-01 0.822 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 2.481929e-01 0.605 0 0
Ca-dependent events R-HSA-111996 2.225931e-01 0.652 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.671551e-01 0.777 0 0
Platelet activation, signaling and aggregation R-HSA-76002 2.060650e-01 0.686 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 2.055917e-01 0.687 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 2.055917e-01 0.687 0 0
Inhibition of PKR R-HSA-169131 2.055917e-01 0.687 0 0
Reelin signalling pathway R-HSA-8866376 1.931718e-01 0.714 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.350466e-01 0.629 1 0
Bicarbonate transporters R-HSA-425381 2.194453e-01 0.659 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 2.491260e-01 0.604 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.491260e-01 0.604 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.190173e-01 0.660 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 1.457912e-01 0.836 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.847135e-01 0.734 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.832351e-01 0.737 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.666833e-01 0.778 0 0
TNF signaling R-HSA-75893 2.079489e-01 0.682 0 0
Calmodulin induced events R-HSA-111933 2.300617e-01 0.638 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.474580e-01 0.831 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 1.389386e-01 0.857 0 0
DAG and IP3 signaling R-HSA-1489509 1.627963e-01 0.788 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.389731e-01 0.857 0 0
CaM pathway R-HSA-111997 2.300617e-01 0.638 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 1.595482e-01 0.797 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 1.389731e-01 0.857 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.440838e-01 0.612 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 1.523528e-01 0.817 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.527612e-01 0.816 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.350466e-01 0.629 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 2.530635e-01 0.597 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 2.376916e-01 0.624 0 0
Formation of definitive endoderm R-HSA-9823730 1.643362e-01 0.784 0 0
Regulated Necrosis R-HSA-5218859 2.639488e-01 0.578 0 0
HCMV Late Events R-HSA-9610379 1.633340e-01 0.787 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 1.389731e-01 0.857 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 2.290129e-01 0.640 0 0
G1 Phase R-HSA-69236 2.535573e-01 0.596 0 0
Cyclin D associated events in G1 R-HSA-69231 2.535573e-01 0.596 0 0
Signaling by KIT in disease R-HSA-9669938 2.231964e-01 0.651 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 1.931718e-01 0.714 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 1.778786e-01 0.750 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.028839e-01 0.693 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.741275e-01 0.562 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 1.830162e-01 0.738 0 0
Potential therapeutics for SARS R-HSA-9679191 1.690279e-01 0.772 0 0
Somitogenesis R-HSA-9824272 1.627963e-01 0.788 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.838728e-01 0.735 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.350466e-01 0.629 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 2.440838e-01 0.612 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 1.778786e-01 0.750 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.832351e-01 0.737 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.391678e-01 0.856 0 0
Oncogene Induced Senescence R-HSA-2559585 2.136144e-01 0.670 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 2.440838e-01 0.612 0 0
Trafficking of AMPA receptors R-HSA-399719 2.561822e-01 0.591 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 2.546564e-01 0.594 0 0
Glycogen synthesis R-HSA-3322077 1.643362e-01 0.784 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 1.838728e-01 0.735 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 2.246542e-01 0.648 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.380287e-01 0.860 0 0
Cellular response to mitochondrial stress R-HSA-9840373 1.618408e-01 0.791 0 0
MHC class II antigen presentation R-HSA-2132295 1.707573e-01 0.768 0 0
Regulation of BACH1 activity R-HSA-9708530 2.008563e-01 0.697 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 1.931718e-01 0.714 0 0
Formation of paraxial mesoderm R-HSA-9793380 2.756726e-01 0.560 0 0
Signaling by LTK in cancer R-HSA-9842640 2.773553e-01 0.557 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.773553e-01 0.557 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.773553e-01 0.557 0 0
Neurofascin interactions R-HSA-447043 2.773553e-01 0.557 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.773553e-01 0.557 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.782253e-01 0.556 0 0
Post-translational protein phosphorylation R-HSA-8957275 2.786559e-01 0.555 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.787441e-01 0.555 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.803997e-01 0.552 0 0
Pervasive developmental disorders R-HSA-9005895 2.803997e-01 0.552 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 2.803997e-01 0.552 0 0
Disorders of Nervous System Development R-HSA-9697154 2.803997e-01 0.552 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.803997e-01 0.552 0 0
Polymerase switching R-HSA-69091 2.803997e-01 0.552 0 0
Leading Strand Synthesis R-HSA-69109 2.803997e-01 0.552 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.803997e-01 0.552 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.803997e-01 0.552 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.803997e-01 0.552 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.803997e-01 0.552 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.803997e-01 0.552 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 2.803997e-01 0.552 0 0
Signaling by ALK R-HSA-201556 2.816816e-01 0.550 0 0
Signaling by TGFBR3 R-HSA-9839373 2.857649e-01 0.544 1 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 2.919548e-01 0.535 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.919548e-01 0.535 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 2.919548e-01 0.535 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.919548e-01 0.535 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.919548e-01 0.535 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.919548e-01 0.535 0 0
Adaptive Immune System R-HSA-1280218 2.933265e-01 0.533 0 0
Developmental Cell Lineages R-HSA-9734767 2.947492e-01 0.531 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.948803e-01 0.530 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.948803e-01 0.530 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.948803e-01 0.530 0 0
Cilium Assembly R-HSA-5617833 2.988595e-01 0.525 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.995192e-01 0.524 0 0
Rap1 signalling R-HSA-392517 2.995192e-01 0.524 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 2.995192e-01 0.524 0 0
Other interleukin signaling R-HSA-449836 2.995192e-01 0.524 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.093039e-01 0.510 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.093039e-01 0.510 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.093039e-01 0.510 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.093039e-01 0.510 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 3.114691e-01 0.507 0 0
Selenocysteine synthesis R-HSA-2408557 3.130956e-01 0.504 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 3.146502e-01 0.502 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 3.175390e-01 0.498 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.189326e-01 0.496 0 0
Gluconeogenesis R-HSA-70263 3.189326e-01 0.496 0 0
Ion homeostasis R-HSA-5578775 3.193567e-01 0.496 0 0
Activation of TRKA receptors R-HSA-187015 3.195091e-01 0.496 0 0
MECP2 regulates transcription factors R-HSA-9022707 3.195091e-01 0.496 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.195091e-01 0.496 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.195091e-01 0.496 0 0
PTK6 Expression R-HSA-8849473 3.195091e-01 0.496 0 0
CHL1 interactions R-HSA-447041 3.195091e-01 0.496 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.195091e-01 0.496 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.195091e-01 0.496 0 0
Signal transduction by L1 R-HSA-445144 3.251669e-01 0.488 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.316042e-01 0.479 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.316042e-01 0.479 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 3.316042e-01 0.479 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 3.316042e-01 0.479 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.341149e-01 0.476 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.341149e-01 0.476 0 0
RAF activation R-HSA-5673000 3.346192e-01 0.475 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 3.346192e-01 0.475 0 0
Negative regulation of MAPK pathway R-HSA-5675221 3.357632e-01 0.474 0 0
Translation of Structural Proteins R-HSA-9683701 3.357632e-01 0.474 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.426227e-01 0.465 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 3.426227e-01 0.465 0 0
Signal regulatory protein family interactions R-HSA-391160 3.426227e-01 0.465 0 0
Circadian clock R-HSA-9909396 3.474188e-01 0.459 0 0
Lagging Strand Synthesis R-HSA-69186 3.509440e-01 0.455 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 3.509440e-01 0.455 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 3.509440e-01 0.455 0 0
HIV elongation arrest and recovery R-HSA-167287 3.540439e-01 0.451 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.540439e-01 0.451 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.540439e-01 0.451 0 0
Developmental Biology R-HSA-1266738 3.574996e-01 0.447 0 0
Type I hemidesmosome assembly R-HSA-446107 3.610421e-01 0.442 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.610421e-01 0.442 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.610421e-01 0.442 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.610421e-01 0.442 0 0
Formation of annular gap junctions R-HSA-196025 3.610421e-01 0.442 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.610421e-01 0.442 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.610421e-01 0.442 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 3.651066e-01 0.438 0 0
Extension of Telomeres R-HSA-180786 3.669334e-01 0.435 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 3.689335e-01 0.433 0 0
Glycogen storage disease type IV (GBE1) R-HSA-3878781 3.689335e-01 0.433 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.689335e-01 0.433 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.689335e-01 0.433 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.689335e-01 0.433 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 3.689335e-01 0.433 0 0
Signalling to ERK5 R-HSA-198765 3.689335e-01 0.433 0 0
C6 deamination of adenosine R-HSA-75102 3.689335e-01 0.433 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 3.689335e-01 0.433 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.736568e-01 0.428 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.736568e-01 0.428 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 3.736568e-01 0.428 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 3.736568e-01 0.428 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 3.736568e-01 0.428 0 0
G1/S-Specific Transcription R-HSA-69205 3.749184e-01 0.426 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.765433e-01 0.424 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 3.766597e-01 0.424 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 3.766597e-01 0.424 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 3.766597e-01 0.424 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.767315e-01 0.424 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.767315e-01 0.424 0 0
Neurexins and neuroligins R-HSA-6794361 3.870035e-01 0.412 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 3.870035e-01 0.412 0 0
FOXO-mediated transcription R-HSA-9614085 3.892720e-01 0.410 0 0
Immune System R-HSA-168256 3.981739e-01 0.400 0 0
Interleukin-37 signaling R-HSA-9008059 3.990267e-01 0.399 0 0
Gap junction degradation R-HSA-190873 4.015911e-01 0.396 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.015911e-01 0.396 0 0
Calcineurin activates NFAT R-HSA-2025928 4.015911e-01 0.396 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 4.015911e-01 0.396 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.015911e-01 0.396 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.015911e-01 0.396 0 0
Regulation of NPAS4 gene transcription R-HSA-9768777 4.015911e-01 0.396 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.015911e-01 0.396 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.015911e-01 0.396 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 4.015911e-01 0.396 0 0
FGFR2 alternative splicing R-HSA-6803529 4.024191e-01 0.395 0 0
Notch-HLH transcription pathway R-HSA-350054 4.024191e-01 0.395 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 4.024191e-01 0.395 0 0
G alpha (12/13) signalling events R-HSA-416482 4.039371e-01 0.394 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 4.040804e-01 0.394 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 4.043912e-01 0.393 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 4.043912e-01 0.393 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 4.043912e-01 0.393 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.115384e-01 0.386 0 0
Protein localization R-HSA-9609507 4.121083e-01 0.385 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.125694e-01 0.385 0 0
Metabolism of proteins R-HSA-392499 4.231257e-01 0.374 1 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 4.279058e-01 0.369 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 4.279058e-01 0.369 0 0
Syndecan interactions R-HSA-3000170 4.279058e-01 0.369 0 0
Disorders of transmembrane transporters R-HSA-5619115 4.325572e-01 0.364 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.335033e-01 0.363 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 4.346686e-01 0.362 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 4.346686e-01 0.362 0 0
Synthesis of PG R-HSA-1483148 4.346686e-01 0.362 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 4.346686e-01 0.362 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.375472e-01 0.359 0 0
MET interacts with TNS proteins R-HSA-8875513 4.375472e-01 0.359 0 0
Invadopodia formation R-HSA-8941237 4.375472e-01 0.359 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 4.375472e-01 0.359 0 0
Signalling to STAT3 R-HSA-198745 4.375472e-01 0.359 0 0
MET activates PTPN11 R-HSA-8865999 4.375472e-01 0.359 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 4.375472e-01 0.359 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.375472e-01 0.359 0 0
MET activates STAT3 R-HSA-8875791 4.375472e-01 0.359 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 4.375472e-01 0.359 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 4.375472e-01 0.359 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 4.375472e-01 0.359 0 0
Histamine receptors R-HSA-390650 4.375472e-01 0.359 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 4.375472e-01 0.359 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 4.383456e-01 0.358 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.408794e-01 0.356 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.408794e-01 0.356 0 0
Parasite infection R-HSA-9664407 4.439863e-01 0.353 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.439863e-01 0.353 0 0
Leishmania phagocytosis R-HSA-9664417 4.439863e-01 0.353 0 0
Ion transport by P-type ATPases R-HSA-936837 4.472802e-01 0.349 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 4.513904e-01 0.345 0 0
Deadenylation of mRNA R-HSA-429947 4.530995e-01 0.344 0 0
Neurodegenerative Diseases R-HSA-8863678 4.530995e-01 0.344 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.530995e-01 0.344 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 4.548052e-01 0.342 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 4.643538e-01 0.333 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 4.643538e-01 0.333 0 0
Uptake and function of anthrax toxins R-HSA-5210891 4.643538e-01 0.333 0 0
Integrin signaling R-HSA-354192 4.656911e-01 0.332 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.656911e-01 0.332 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.688688e-01 0.329 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.703467e-01 0.328 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 4.752287e-01 0.323 0 0
Tight junction interactions R-HSA-420029 4.779179e-01 0.321 0 0
TGFBR3 expression R-HSA-9839394 4.779179e-01 0.321 0 0
Signaling by APC mutants R-HSA-4839744 4.787019e-01 0.320 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.787019e-01 0.320 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.787019e-01 0.320 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.787019e-01 0.320 0 0
Synthesis of PI R-HSA-1483226 4.787019e-01 0.320 0 0
vRNP Assembly R-HSA-192905 4.787019e-01 0.320 0 0
Suppression of apoptosis R-HSA-9635465 4.787019e-01 0.320 0 0
Interleukin-2 signaling R-HSA-9020558 4.787019e-01 0.320 0 0
ChREBP activates metabolic gene expression R-HSA-163765 4.787019e-01 0.320 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.815346e-01 0.317 0 0
Gap junction trafficking and regulation R-HSA-157858 4.829152e-01 0.316 0 0
Iron uptake and transport R-HSA-917937 4.849734e-01 0.314 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 4.907062e-01 0.309 0 0
GAB1 signalosome R-HSA-180292 4.933323e-01 0.307 0 0
Apoptotic factor-mediated response R-HSA-111471 4.933323e-01 0.307 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.933323e-01 0.307 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 4.946216e-01 0.306 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.987042e-01 0.302 0 0
HCN channels R-HSA-1296061 4.987042e-01 0.302 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.987042e-01 0.302 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 4.987042e-01 0.302 0 0
Regulation of gap junction activity R-HSA-191650 4.987042e-01 0.302 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.987042e-01 0.302 0 0
Transcriptional activation of cell cycle inhibitor p21 R-HSA-69895 4.987042e-01 0.302 0 0
Transcriptional activation of p53 responsive genes R-HSA-69560 4.987042e-01 0.302 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.987042e-01 0.302 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.987042e-01 0.302 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 5.022874e-01 0.299 0 0
Peroxisomal protein import R-HSA-9033241 5.060665e-01 0.296 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.060665e-01 0.296 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 5.088732e-01 0.293 0 0
Transcription of the HIV genome R-HSA-167172 5.106056e-01 0.292 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.141704e-01 0.289 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 5.149130e-01 0.288 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 5.149130e-01 0.288 0 0
Signaling by AXIN mutants R-HSA-4839735 5.149130e-01 0.288 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 5.149130e-01 0.288 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 5.149130e-01 0.288 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.154606e-01 0.288 0 0
Interferon alpha/beta signaling R-HSA-909733 5.186644e-01 0.285 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 5.215090e-01 0.283 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 5.215090e-01 0.283 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 5.215090e-01 0.283 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 5.215090e-01 0.283 0 0
The NLRP3 inflammasome R-HSA-844456 5.215090e-01 0.283 0 0
Maturation of nucleoprotein R-HSA-9694631 5.215090e-01 0.283 0 0
tRNA Aminoacylation R-HSA-379724 5.225876e-01 0.282 0 0
Metabolism of polyamines R-HSA-351202 5.225876e-01 0.282 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 5.261437e-01 0.279 0 0
Cristae formation R-HSA-8949613 5.261437e-01 0.279 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.261437e-01 0.279 0 0
Insulin processing R-HSA-264876 5.261437e-01 0.279 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 5.278130e-01 0.278 0 0
Signaling by FGFR4 R-HSA-5654743 5.332258e-01 0.273 0 0
PLC beta mediated events R-HSA-112043 5.389097e-01 0.268 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 5.488068e-01 0.261 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 5.488068e-01 0.261 0 0
Protein hydroxylation R-HSA-9629569 5.488068e-01 0.261 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 5.492429e-01 0.260 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 5.494159e-01 0.260 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.494159e-01 0.260 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 5.494159e-01 0.260 0 0
Telomere Extension By Telomerase R-HSA-171319 5.494313e-01 0.260 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 5.494313e-01 0.260 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.494313e-01 0.260 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.494313e-01 0.260 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.494313e-01 0.260 0 0
DAP12 interactions R-HSA-2172127 5.519597e-01 0.258 0 0
Netrin-1 signaling R-HSA-373752 5.519597e-01 0.258 0 0
Gap junction trafficking R-HSA-190828 5.519597e-01 0.258 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.532147e-01 0.257 0 0
G2 Phase R-HSA-68911 5.532147e-01 0.257 0 0
NTRK2 activates RAC1 R-HSA-9032759 5.532147e-01 0.257 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 5.532147e-01 0.257 0 0
Defective F9 activation R-HSA-9673221 5.532147e-01 0.257 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 5.532147e-01 0.257 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 5.532147e-01 0.257 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 5.532147e-01 0.257 0 0
Activation of AKT2 R-HSA-165158 5.532147e-01 0.257 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 5.532147e-01 0.257 0 0
Suppression of autophagy R-HSA-9636569 5.532147e-01 0.257 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.532147e-01 0.257 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.532147e-01 0.257 0 0
NrCAM interactions R-HSA-447038 5.532147e-01 0.257 0 0
Toxicity of botulinum toxin type C (botC) R-HSA-5250971 5.532147e-01 0.257 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 5.532147e-01 0.257 0 0
NCAM signaling for neurite out-growth R-HSA-375165 5.550112e-01 0.256 0 0
Signaling by FGFR2 R-HSA-5654738 5.581512e-01 0.253 0 0
Response of endothelial cells to shear stress R-HSA-9860931 5.627704e-01 0.250 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 5.657402e-01 0.247 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.657402e-01 0.247 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 5.703427e-01 0.244 0 0
Signaling by FGFR3 R-HSA-5654741 5.703427e-01 0.244 0 0
mRNA Capping R-HSA-72086 5.721028e-01 0.243 0 0
DARPP-32 events R-HSA-180024 5.721028e-01 0.243 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.751649e-01 0.240 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 5.751649e-01 0.240 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 5.815933e-01 0.235 0 0
Neddylation R-HSA-8951664 5.816863e-01 0.235 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.821540e-01 0.235 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 5.821540e-01 0.235 0 0
Frs2-mediated activation R-HSA-170968 5.821540e-01 0.235 0 0
Formation of axial mesoderm R-HSA-9796292 5.821540e-01 0.235 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 5.821540e-01 0.235 0 0
Maturation of nucleoprotein R-HSA-9683610 5.821540e-01 0.235 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 5.821540e-01 0.235 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 5.879723e-01 0.231 0 0
Regulation of pyruvate metabolism R-HSA-9861718 5.883486e-01 0.230 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.904822e-01 0.229 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 5.941188e-01 0.226 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.998866e-01 0.222 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 5.998866e-01 0.222 0 0
NGF-independant TRKA activation R-HSA-187024 6.018007e-01 0.221 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 6.018007e-01 0.221 0 0
Phosphorylation of Emi1 R-HSA-176417 6.018007e-01 0.221 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 6.018007e-01 0.221 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 6.018007e-01 0.221 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 6.018007e-01 0.221 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 6.018007e-01 0.221 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 6.018007e-01 0.221 0 0
Toxicity of botulinum toxin type E (botE) R-HSA-5250992 6.018007e-01 0.221 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 6.018007e-01 0.221 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 6.018007e-01 0.221 0 0
Pentose phosphate pathway disease R-HSA-6791465 6.018007e-01 0.221 0 0
PDE3B signalling R-HSA-165160 6.018007e-01 0.221 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 6.018007e-01 0.221 0 0
PKB-mediated events R-HSA-109703 6.018007e-01 0.221 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 6.018007e-01 0.221 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 6.018007e-01 0.221 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 6.018007e-01 0.221 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 6.018007e-01 0.221 0 0
TRAIL signaling R-HSA-75158 6.018007e-01 0.221 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 6.018007e-01 0.221 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 6.034670e-01 0.219 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.096854e-01 0.215 0 0
Plasma lipoprotein clearance R-HSA-8964043 6.096854e-01 0.215 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 6.096854e-01 0.215 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 6.111188e-01 0.214 0 0
Removal of the Flap Intermediate R-HSA-69166 6.131031e-01 0.212 0 0
Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-HSA-77350 6.131031e-01 0.212 0 0
Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-HSA-77348 6.131031e-01 0.212 0 0
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-HSA-77310 6.131031e-01 0.212 0 0
Malate-aspartate shuttle R-HSA-9856872 6.131031e-01 0.212 0 0
Acyl chain remodeling of CL R-HSA-1482798 6.131031e-01 0.212 0 0
Zinc transporters R-HSA-435354 6.131031e-01 0.212 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 6.131031e-01 0.212 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 6.149163e-01 0.211 0 0
Molecules associated with elastic fibres R-HSA-2129379 6.154471e-01 0.211 0 0
Downstream signal transduction R-HSA-186763 6.154471e-01 0.211 0 0
Intraflagellar transport R-HSA-5620924 6.231392e-01 0.205 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.248906e-01 0.204 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 6.248906e-01 0.204 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 6.248906e-01 0.204 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 6.283560e-01 0.202 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 6.283560e-01 0.202 0 0
HIV Transcription Elongation R-HSA-167169 6.283560e-01 0.202 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 6.283560e-01 0.202 0 0
Glycogen metabolism R-HSA-8982491 6.283560e-01 0.202 0 0
G-protein mediated events R-HSA-112040 6.315604e-01 0.200 0 0
Signaling by WNT in cancer R-HSA-4791275 6.360627e-01 0.197 0 0
Gastrulation R-HSA-9758941 6.411260e-01 0.193 0 0
Erythropoietin activates RAS R-HSA-9027284 6.422652e-01 0.192 0 0
DNA Damage Reversal R-HSA-73942 6.422652e-01 0.192 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.451056e-01 0.190 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.451056e-01 0.190 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 6.451056e-01 0.190 0 0
STAT5 Activation R-HSA-9645135 6.451056e-01 0.190 0 0
Metabolism of ingested MeSeO2H into MeSeH R-HSA-5263617 6.451056e-01 0.190 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.451056e-01 0.190 0 0
MET Receptor Activation R-HSA-6806942 6.451056e-01 0.190 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 6.451056e-01 0.190 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 6.451056e-01 0.190 0 0
CREB phosphorylation R-HSA-199920 6.451056e-01 0.190 0 0
VLDL assembly R-HSA-8866423 6.451056e-01 0.190 0 0
Leukotriene receptors R-HSA-391906 6.451056e-01 0.190 0 0
CREB3 factors activate genes R-HSA-8874211 6.451056e-01 0.190 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.500221e-01 0.187 0 0
G-protein beta:gamma signalling R-HSA-397795 6.559466e-01 0.183 0 0
FGFR1 mutant receptor activation R-HSA-1839124 6.559466e-01 0.183 0 0
Cardiogenesis R-HSA-9733709 6.559466e-01 0.183 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 6.559466e-01 0.183 0 0
Nuclear Receptor transcription pathway R-HSA-383280 6.559521e-01 0.183 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.640280e-01 0.178 0 0
HIV Transcription Initiation R-HSA-167161 6.640280e-01 0.178 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.640280e-01 0.178 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.640280e-01 0.178 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.640280e-01 0.178 0 0
Inositol phosphate metabolism R-HSA-1483249 6.683144e-01 0.175 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.696628e-01 0.174 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 6.696628e-01 0.174 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 6.696628e-01 0.174 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.696628e-01 0.174 0 0
Activation of SMO R-HSA-5635838 6.696628e-01 0.174 0 0
Virus Assembly and Release R-HSA-168268 6.696628e-01 0.174 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 6.704676e-01 0.174 0 0
Mitochondrial RNA degradation R-HSA-9836573 6.704676e-01 0.174 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.704676e-01 0.174 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.704676e-01 0.174 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.704676e-01 0.174 0 0
Opioid Signalling R-HSA-111885 6.708553e-01 0.173 0 0
MAP kinase activation R-HSA-450294 6.797527e-01 0.168 0 0
Signaling by MET R-HSA-6806834 6.818612e-01 0.166 0 0
RSV-host interactions R-HSA-9833110 6.820229e-01 0.166 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 6.837033e-01 0.165 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.837033e-01 0.165 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 6.837033e-01 0.165 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 6.837033e-01 0.165 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.837033e-01 0.165 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.837033e-01 0.165 0 0
Disinhibition of SNARE formation R-HSA-114516 6.837033e-01 0.165 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 6.837033e-01 0.165 0 0
LDL remodeling R-HSA-8964041 6.837033e-01 0.165 0 0
VLDL clearance R-HSA-8964046 6.837033e-01 0.165 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.837033e-01 0.165 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.916788e-01 0.160 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.916788e-01 0.160 0 0
Formation of the nephric duct R-HSA-9830364 6.916788e-01 0.160 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 6.934732e-01 0.159 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.934732e-01 0.159 0 0
Gap junction assembly R-HSA-190861 6.934732e-01 0.159 0 0
Mitochondrial protein import R-HSA-1268020 6.938388e-01 0.159 0 0
Signaling by PDGF R-HSA-186797 6.938388e-01 0.159 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 6.953348e-01 0.158 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.953348e-01 0.158 0 0
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-HSA-77346 6.953348e-01 0.158 0 0
Passive transport by Aquaporins R-HSA-432047 6.953348e-01 0.158 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.973925e-01 0.157 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 7.002553e-01 0.155 0 0
Signalling to ERKs R-HSA-187687 7.111054e-01 0.148 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.118439e-01 0.148 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.151695e-01 0.146 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 7.169958e-01 0.144 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 7.181053e-01 0.144 0 0
phospho-PLA2 pathway R-HSA-111995 7.181053e-01 0.144 0 0
MET receptor recycling R-HSA-8875656 7.181053e-01 0.144 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 7.181053e-01 0.144 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 7.181053e-01 0.144 0 0
Co-stimulation by ICOS R-HSA-9927354 7.181053e-01 0.144 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 7.181053e-01 0.144 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.181053e-01 0.144 0 0
SLC-mediated bile acid transport R-HSA-9958517 7.181053e-01 0.144 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 7.181053e-01 0.144 0 0
TGFBR3 PTM regulation R-HSA-9839383 7.181053e-01 0.144 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 7.181053e-01 0.144 0 0
Sodium/Proton exchangers R-HSA-425986 7.181053e-01 0.144 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 7.181053e-01 0.144 0 0
Interleukin-23 signaling R-HSA-9020933 7.181053e-01 0.144 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 7.193323e-01 0.143 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 7.193323e-01 0.143 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 7.193323e-01 0.143 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 7.193323e-01 0.143 0 0
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se R-HSA-2408550 7.193323e-01 0.143 0 0
Choline catabolism R-HSA-6798163 7.193323e-01 0.143 0 0
Specification of primordial germ cells R-HSA-9827857 7.193323e-01 0.143 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 7.193323e-01 0.143 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.207817e-01 0.142 0 0
RET signaling R-HSA-8853659 7.279839e-01 0.138 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 7.279839e-01 0.138 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 7.283984e-01 0.138 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 7.309759e-01 0.136 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.309759e-01 0.136 0 0
Infectious disease R-HSA-5663205 7.372745e-01 0.132 0 0
PKA activation R-HSA-163615 7.417159e-01 0.130 0 0
Synaptic adhesion-like molecules R-HSA-8849932 7.417159e-01 0.130 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 7.417159e-01 0.130 0 0
Signaling by FGFR1 R-HSA-5654736 7.439563e-01 0.128 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 7.453030e-01 0.128 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 7.487672e-01 0.126 0 0
Lipophagy R-HSA-9613354 7.487672e-01 0.126 0 0
Toxicity of botulinum toxin type A (botA) R-HSA-5250968 7.487672e-01 0.126 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 7.487672e-01 0.126 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.487672e-01 0.126 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.487672e-01 0.126 0 0
mRNA Editing R-HSA-75072 7.487672e-01 0.126 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.487672e-01 0.126 0 0
Interleukin-1 processing R-HSA-448706 7.487672e-01 0.126 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.487672e-01 0.126 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 7.487672e-01 0.126 0 0
Butyrophilin (BTN) family interactions R-HSA-8851680 7.487672e-01 0.126 0 0
Pyroptosis R-HSA-5620971 7.490931e-01 0.125 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.490931e-01 0.125 0 0
Inflammasomes R-HSA-622312 7.490931e-01 0.125 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 7.521044e-01 0.124 0 0
Dectin-2 family R-HSA-5621480 7.568837e-01 0.121 0 0
Elastic fibre formation R-HSA-1566948 7.595044e-01 0.119 0 0
Translation of Structural Proteins R-HSA-9694635 7.601172e-01 0.119 0 0
FCERI mediated NF-kB activation R-HSA-2871837 7.623039e-01 0.118 0 0
Germ layer formation at gastrulation R-HSA-9754189 7.625527e-01 0.118 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 7.625527e-01 0.118 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 7.625527e-01 0.118 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 7.625527e-01 0.118 0 0
Specification of the neural plate border R-HSA-9834899 7.625527e-01 0.118 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 7.625527e-01 0.118 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 7.625527e-01 0.118 0 0
Signaling by Erythropoietin R-HSA-9006335 7.662187e-01 0.116 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.693262e-01 0.114 0 0
Selenoamino acid metabolism R-HSA-2408522 7.708214e-01 0.113 0 0
Integrin cell surface interactions R-HSA-216083 7.710005e-01 0.113 0 0
Pyruvate metabolism R-HSA-70268 7.729498e-01 0.112 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 7.741667e-01 0.111 0 0
RAS processing R-HSA-9648002 7.741667e-01 0.111 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 7.760957e-01 0.110 0 0
Receptor Mediated Mitophagy R-HSA-8934903 7.760957e-01 0.110 0 0
Binding and entry of HIV virion R-HSA-173107 7.760957e-01 0.110 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.760957e-01 0.110 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.760957e-01 0.110 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 7.760957e-01 0.110 0 0
Regulation of the apoptosome activity R-HSA-9627069 7.760957e-01 0.110 0 0
Interleukin-27 signaling R-HSA-9020956 7.760957e-01 0.110 0 0
Maturation of spike protein R-HSA-9683686 7.760957e-01 0.110 0 0
Formation of apoptosome R-HSA-111458 7.760957e-01 0.110 0 0
Amino acid transport across the plasma membrane R-HSA-352230 7.812878e-01 0.107 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.819143e-01 0.107 0 0
Signaling by NODAL R-HSA-1181150 7.819143e-01 0.107 0 0
Creatine metabolism R-HSA-71288 7.819143e-01 0.107 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 7.819143e-01 0.107 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.819143e-01 0.107 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.823797e-01 0.107 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 7.823797e-01 0.107 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.881149e-01 0.103 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.881149e-01 0.103 0 0
Interleukin-17 signaling R-HSA-448424 7.916502e-01 0.101 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 7.927742e-01 0.101 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.976060e-01 0.098 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 7.998750e-01 0.097 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 7.998750e-01 0.097 0 0
vRNA Synthesis R-HSA-192814 8.004529e-01 0.097 0 0
Chylomicron assembly R-HSA-8963888 8.004529e-01 0.097 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 8.004529e-01 0.097 0 0
LGI-ADAM interactions R-HSA-5682910 8.004529e-01 0.097 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 8.004529e-01 0.097 0 0
Prostanoid ligand receptors R-HSA-391908 8.004529e-01 0.097 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 8.004529e-01 0.097 0 0
Dissolution of Fibrin Clot R-HSA-75205 8.004529e-01 0.097 0 0
Signaling by FGFR R-HSA-190236 8.027347e-01 0.095 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.139363e-01 0.089 0 0
Attachment and Entry R-HSA-9694614 8.165104e-01 0.088 0 0
Mitochondrial calcium ion transport R-HSA-8949215 8.165104e-01 0.088 0 0
Rab regulation of trafficking R-HSA-9007101 8.212115e-01 0.086 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 8.215824e-01 0.085 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.221617e-01 0.085 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 8.221617e-01 0.085 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 8.221617e-01 0.085 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.221617e-01 0.085 0 0
Plasmalogen biosynthesis R-HSA-75896 8.221617e-01 0.085 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 8.221617e-01 0.085 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 8.221617e-01 0.085 0 0
Endosomal/Vacuolar pathway R-HSA-1236977 8.221617e-01 0.085 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 8.244539e-01 0.084 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.253862e-01 0.083 0 0
Toll-like Receptor Cascades R-HSA-168898 8.298729e-01 0.081 0 0
Signaling by FGFR in disease R-HSA-1226099 8.307784e-01 0.081 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 8.318962e-01 0.080 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 8.364560e-01 0.078 0 0
TBC/RABGAPs R-HSA-8854214 8.371184e-01 0.077 0 0
Innate Immune System R-HSA-168249 8.396618e-01 0.076 0 0
MET activates RAS signaling R-HSA-8851805 8.415099e-01 0.075 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.415099e-01 0.075 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 8.415099e-01 0.075 0 0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656253 8.415099e-01 0.075 0 0
Defective EXT2 causes exostoses 2 R-HSA-3656237 8.415099e-01 0.075 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.415099e-01 0.075 0 0
Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-HSA-77305 8.415099e-01 0.075 0 0
Beta oxidation of myristoyl-CoA to lauroyl-CoA R-HSA-77285 8.415099e-01 0.075 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 8.415099e-01 0.075 0 0
GRB2 events in EGFR signaling R-HSA-179812 8.415099e-01 0.075 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 8.415099e-01 0.075 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 8.415099e-01 0.075 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 8.415099e-01 0.075 0 0
Regulation of IFNG signaling R-HSA-877312 8.415099e-01 0.075 0 0
Signaling by LTK R-HSA-9842663 8.415099e-01 0.075 0 0
Interleukin-35 Signalling R-HSA-8984722 8.415099e-01 0.075 0 0
OAS antiviral response R-HSA-8983711 8.415099e-01 0.075 0 0
Mitochondrial protein degradation R-HSA-9837999 8.436791e-01 0.074 0 0
Termination of O-glycan biosynthesis R-HSA-977068 8.461074e-01 0.073 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.461074e-01 0.073 0 0
Synthesis of UDP-N-acetyl-glucosamine R-HSA-446210 8.461074e-01 0.073 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 8.461074e-01 0.073 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.498369e-01 0.071 0 0
SLC transporter disorders R-HSA-5619102 8.529922e-01 0.069 0 0
Signaling by NTRKs R-HSA-166520 8.567329e-01 0.067 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 8.587541e-01 0.066 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 8.587541e-01 0.066 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 8.587541e-01 0.066 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 8.587541e-01 0.066 0 0
Interleukin-6 signaling R-HSA-1059683 8.587541e-01 0.066 0 0
Complex III assembly R-HSA-9865881 8.592173e-01 0.066 0 0
Plasma lipoprotein assembly R-HSA-8963898 8.592173e-01 0.066 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.605544e-01 0.065 0 0
Hemostasis R-HSA-109582 8.606757e-01 0.065 0 0
Interferon gamma signaling R-HSA-877300 8.630081e-01 0.064 0 0
Ion channel transport R-HSA-983712 8.706314e-01 0.060 0 0
RUNX2 regulates bone development R-HSA-8941326 8.712489e-01 0.060 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.712489e-01 0.060 0 0
Triglyceride catabolism R-HSA-163560 8.712489e-01 0.060 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 8.712974e-01 0.060 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 8.712974e-01 0.060 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.712974e-01 0.060 0 0
Interleukin-7 signaling R-HSA-1266695 8.712974e-01 0.060 0 0
tRNA processing R-HSA-72306 8.739695e-01 0.059 0 0
CRMPs in Sema3A signaling R-HSA-399956 8.741229e-01 0.058 0 0
Retrograde neurotrophin signalling R-HSA-177504 8.741229e-01 0.058 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.741229e-01 0.058 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 8.741229e-01 0.058 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 8.741229e-01 0.058 0 0
Hydrolysis of LPC R-HSA-1483115 8.741229e-01 0.058 0 0
Signaling by FGFR4 in disease R-HSA-5655291 8.741229e-01 0.058 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 8.741229e-01 0.058 0 0
Non-canonical inflammasome activation R-HSA-9686114 8.741229e-01 0.058 0 0
HDL assembly R-HSA-8963896 8.741229e-01 0.058 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 8.762536e-01 0.057 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 8.762536e-01 0.057 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.783007e-01 0.056 0 0
MET activates PTK2 signaling R-HSA-8874081 8.824164e-01 0.054 0 0
COPII-mediated vesicle transport R-HSA-204005 8.834111e-01 0.054 0 0
NGF-stimulated transcription R-HSA-9031628 8.846644e-01 0.053 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.878203e-01 0.052 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.878203e-01 0.052 0 0
Signaling by Activin R-HSA-1502540 8.878203e-01 0.052 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 8.878203e-01 0.052 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 8.878203e-01 0.052 0 0
Protein lipoylation R-HSA-9857492 8.878203e-01 0.052 0 0
Beta oxidation of butanoyl-CoA to acetyl-CoA R-HSA-77352 8.878203e-01 0.052 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 8.878203e-01 0.052 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 8.899142e-01 0.051 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 8.899144e-01 0.051 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 8.902912e-01 0.050 0 0
RAB geranylgeranylation R-HSA-8873719 8.903975e-01 0.050 0 0
Maturation of hRSV A proteins R-HSA-9828806 8.926405e-01 0.049 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 8.958232e-01 0.048 0 0
Pentose phosphate pathway R-HSA-71336 8.983066e-01 0.047 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.991074e-01 0.046 0 0
Atorvastatin ADME R-HSA-9754706 9.000280e-01 0.046 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 9.000280e-01 0.046 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 9.000280e-01 0.046 0 0
Fructose catabolism R-HSA-70350 9.000280e-01 0.046 0 0
Attachment and Entry R-HSA-9678110 9.000280e-01 0.046 0 0
Ca2+ pathway R-HSA-4086398 9.030189e-01 0.044 0 0
Heme signaling R-HSA-9707616 9.039659e-01 0.044 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.045285e-01 0.044 0 0
Diseases of Immune System R-HSA-5260271 9.061179e-01 0.043 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 9.061179e-01 0.043 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.061179e-01 0.043 0 0
Interleukin-2 family signaling R-HSA-451927 9.061179e-01 0.043 0 0
Regulation of gene expression in beta cells R-HSA-210745 9.106528e-01 0.041 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.106528e-01 0.041 0 0
Platelet calcium homeostasis R-HSA-418360 9.106528e-01 0.041 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 9.109078e-01 0.041 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 9.109078e-01 0.041 0 0
Heme assimilation R-HSA-9927020 9.109078e-01 0.041 0 0
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-HSA-77288 9.109078e-01 0.041 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 9.109078e-01 0.041 0 0
Phase 2 - plateau phase R-HSA-5576893 9.109078e-01 0.041 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 9.109078e-01 0.041 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 9.109078e-01 0.041 0 0
Biosynthesis of maresin-like SPMs R-HSA-9027307 9.109078e-01 0.041 0 0
Coenzyme A biosynthesis R-HSA-196783 9.109078e-01 0.041 0 0
tRNA modification in the mitochondrion R-HSA-6787450 9.109078e-01 0.041 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 9.109078e-01 0.041 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 9.133818e-01 0.039 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.151376e-01 0.039 0 0
Nucleotide biosynthesis R-HSA-8956320 9.196317e-01 0.036 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.201305e-01 0.036 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.201305e-01 0.036 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.206041e-01 0.036 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.206041e-01 0.036 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 9.206041e-01 0.036 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 9.206041e-01 0.036 0 0
Cargo concentration in the ER R-HSA-5694530 9.258010e-01 0.033 0 0
PKA activation in glucagon signalling R-HSA-164378 9.292457e-01 0.032 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 9.292457e-01 0.032 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 9.292457e-01 0.032 0 0
Platelet sensitization by LDL R-HSA-432142 9.292457e-01 0.032 0 0
Tie2 Signaling R-HSA-210993 9.292457e-01 0.032 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 9.324329e-01 0.030 0 0
Stimuli-sensing channels R-HSA-2672351 9.325906e-01 0.030 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.338476e-01 0.030 0 0
Pyrimidine biosynthesis R-HSA-500753 9.369471e-01 0.028 0 0
Diseases of hemostasis R-HSA-9671793 9.369471e-01 0.028 0 0
Synthesis of PA R-HSA-1483166 9.404147e-01 0.027 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.419978e-01 0.026 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.425787e-01 0.026 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.438107e-01 0.025 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 9.438107e-01 0.025 0 0
Acyl chain remodelling of PI R-HSA-1482922 9.438107e-01 0.025 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 9.438107e-01 0.025 0 0
Acyl chain remodelling of PC R-HSA-1482788 9.440487e-01 0.025 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.440487e-01 0.025 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.440487e-01 0.025 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.440487e-01 0.025 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.463249e-01 0.024 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.471940e-01 0.024 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.471940e-01 0.024 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.475555e-01 0.023 0 0
Triglyceride metabolism R-HSA-8979227 9.488536e-01 0.023 0 0
eNOS activation R-HSA-203615 9.491179e-01 0.023 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 9.499275e-01 0.022 0 0
G-protein activation R-HSA-202040 9.499275e-01 0.022 0 0
Signalling to RAS R-HSA-167044 9.499275e-01 0.022 0 0
ERK/MAPK targets R-HSA-198753 9.499275e-01 0.022 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 9.499275e-01 0.022 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 9.499275e-01 0.022 0 0
Acyl chain remodelling of PG R-HSA-1482925 9.499275e-01 0.022 0 0
Synthesis of PC R-HSA-1483191 9.514620e-01 0.022 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 9.519818e-01 0.021 0 0
Acyl chain remodelling of PE R-HSA-1482839 9.537470e-01 0.021 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 9.553787e-01 0.020 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.553787e-01 0.020 0 0
Serine metabolism R-HSA-977347 9.553787e-01 0.020 0 0
Ribavirin ADME R-HSA-9755088 9.553787e-01 0.020 0 0
Metal ion SLC transporters R-HSA-425410 9.554062e-01 0.020 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.561827e-01 0.019 0 0
FGFR2 mutant receptor activation R-HSA-1839126 9.579715e-01 0.019 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 9.602368e-01 0.018 0 0
Fructose metabolism R-HSA-5652084 9.602368e-01 0.018 0 0
LDL clearance R-HSA-8964038 9.602368e-01 0.018 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 9.618248e-01 0.017 0 0
PI3K Cascade R-HSA-109704 9.624105e-01 0.017 0 0
Azathioprine ADME R-HSA-9748787 9.624105e-01 0.017 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.624105e-01 0.017 0 0
Mitochondrial biogenesis R-HSA-1592230 9.645150e-01 0.016 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.645662e-01 0.016 0 0
Formation of the ureteric bud R-HSA-9830674 9.645662e-01 0.016 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.645662e-01 0.016 0 0
Biosynthesis of maresins R-HSA-9018682 9.645662e-01 0.016 0 0
Growth hormone receptor signaling R-HSA-982772 9.645662e-01 0.016 0 0
MET promotes cell motility R-HSA-8875878 9.653376e-01 0.015 0 0
IGF1R signaling cascade R-HSA-2428924 9.653748e-01 0.015 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.680165e-01 0.014 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.684244e-01 0.014 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.684244e-01 0.014 0 0
Interleukin-6 family signaling R-HSA-6783589 9.684244e-01 0.014 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 9.685382e-01 0.014 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.704692e-01 0.013 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.718628e-01 0.012 0 0
Hyaluronan degradation R-HSA-2160916 9.718628e-01 0.012 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 9.718628e-01 0.012 0 0
Laminin interactions R-HSA-3000157 9.718628e-01 0.012 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.722154e-01 0.012 0 0
Cardiac conduction R-HSA-5576891 9.732172e-01 0.012 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.748558e-01 0.011 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.749269e-01 0.011 0 0
TRP channels R-HSA-3295583 9.749269e-01 0.011 0 0
Sphingolipid catabolism R-HSA-9845614 9.749269e-01 0.011 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.749269e-01 0.011 0 0
Extracellular matrix organization R-HSA-1474244 9.755140e-01 0.011 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.763208e-01 0.010 0 0
Intra-Golgi traffic R-HSA-6811438 9.765206e-01 0.010 0 0
Parasitic Infection Pathways R-HSA-9824443 9.771260e-01 0.010 0 0
Leishmania infection R-HSA-9658195 9.771260e-01 0.010 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.776575e-01 0.010 0 0
Triglyceride biosynthesis R-HSA-75109 9.776575e-01 0.010 0 0
Transmission across Chemical Synapses R-HSA-112315 9.776958e-01 0.010 0 0
FCGR activation R-HSA-2029481 9.779988e-01 0.010 0 0
Disease R-HSA-1643685 9.784714e-01 0.009 1 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.787163e-01 0.009 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.787649e-01 0.009 0 0
Collagen formation R-HSA-1474290 9.795320e-01 0.009 0 0
IRS-mediated signalling R-HSA-112399 9.795989e-01 0.009 0 0
Insulin receptor recycling R-HSA-77387 9.800908e-01 0.009 0 0
Prednisone ADME R-HSA-9757110 9.800908e-01 0.009 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.806668e-01 0.008 0 0
Thyroxine biosynthesis R-HSA-209968 9.822593e-01 0.008 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.822593e-01 0.008 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.822593e-01 0.008 0 0
Amine ligand-binding receptors R-HSA-375280 9.825263e-01 0.008 0 0
Regulation of beta-cell development R-HSA-186712 9.829256e-01 0.007 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.829256e-01 0.007 0 0
mitochondrial fatty acid beta-oxidation of saturated fatty acids R-HSA-77286 9.841740e-01 0.007 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.841917e-01 0.007 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.841917e-01 0.007 0 0
Neurotransmitter clearance R-HSA-112311 9.841917e-01 0.007 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 9.841917e-01 0.007 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 9.841917e-01 0.007 0 0
Aquaporin-mediated transport R-HSA-445717 9.857293e-01 0.006 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.869599e-01 0.006 0 0
HS-GAG degradation R-HSA-2024096 9.874482e-01 0.005 0 0
Neurotransmitter release cycle R-HSA-112310 9.886076e-01 0.005 0 0
Insulin receptor signalling cascade R-HSA-74751 9.891223e-01 0.005 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.893787e-01 0.005 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.900342e-01 0.004 0 0
Heme degradation R-HSA-189483 9.900342e-01 0.004 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.911200e-01 0.004 0 0
Hyaluronan metabolism R-HSA-2142845 9.911200e-01 0.004 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.911200e-01 0.004 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.911200e-01 0.004 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 9.911200e-01 0.004 0 0
Signal amplification R-HSA-392518 9.911200e-01 0.004 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.914793e-01 0.004 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.915441e-01 0.004 0 0
Kidney development R-HSA-9830369 9.917312e-01 0.004 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.917653e-01 0.004 0 0
Transferrin endocytosis and recycling R-HSA-917977 9.920876e-01 0.003 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.920876e-01 0.003 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.920876e-01 0.003 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.928990e-01 0.003 0 0
HS-GAG biosynthesis R-HSA-2022928 9.929498e-01 0.003 0 0
Glycosphingolipid transport R-HSA-9845576 9.929498e-01 0.003 0 0
Voltage gated Potassium channels R-HSA-1296072 9.937181e-01 0.003 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.937181e-01 0.003 0 0
NCAM1 interactions R-HSA-419037 9.937181e-01 0.003 0 0
Lysine catabolism R-HSA-71064 9.937181e-01 0.003 0 0
Collagen chain trimerization R-HSA-8948216 9.937181e-01 0.003 0 0
Metabolism of folate and pterines R-HSA-196757 9.937181e-01 0.003 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.937304e-01 0.003 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.940156e-01 0.003 0 0
G alpha (z) signalling events R-HSA-418597 9.942014e-01 0.003 0 0
Neuronal System R-HSA-112316 9.942245e-01 0.003 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.942861e-01 0.002 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.944027e-01 0.002 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.948207e-01 0.002 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.949158e-01 0.002 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.950128e-01 0.002 0 0
Tryptophan catabolism R-HSA-71240 9.955564e-01 0.002 0 0
Formation of the cornified envelope R-HSA-6809371 9.957857e-01 0.002 0 0
Aflatoxin activation and detoxification R-HSA-5423646 9.960407e-01 0.002 0 0
Maturation of spike protein R-HSA-9694548 9.960407e-01 0.002 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.967429e-01 0.001 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.968569e-01 0.001 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.970366e-01 0.001 0 0
Signaling by Insulin receptor R-HSA-74752 9.972538e-01 0.001 0 0
Complex I biogenesis R-HSA-6799198 9.974413e-01 0.001 0 0
Surfactant metabolism R-HSA-5683826 9.975049e-01 0.001 0 0
Methylation R-HSA-156581 9.975049e-01 0.001 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.976919e-01 0.001 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.977769e-01 0.001 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.977769e-01 0.001 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.977958e-01 0.001 0 0
Adipogenesis R-HSA-9843745 9.978894e-01 0.001 0 0
Mitochondrial Fatty Acid Beta-Oxidation R-HSA-77289 9.978987e-01 0.001 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.980193e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.982353e-01 0.001 0 0
GPER1 signaling R-HSA-9634597 9.984278e-01 0.001 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.984278e-01 0.001 0 0
O-linked glycosylation of mucins R-HSA-913709 9.984740e-01 0.001 0 0
Regulation of insulin secretion R-HSA-422356 9.985342e-01 0.001 0 0
Integration of energy metabolism R-HSA-163685 9.986834e-01 0.001 0 0
ECM proteoglycans R-HSA-3000178 9.988829e-01 0.000 0 0
Complex IV assembly R-HSA-9864848 9.988881e-01 0.000 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.988881e-01 0.000 0 0
The phototransduction cascade R-HSA-2514856 9.988881e-01 0.000 0 0
PI Metabolism R-HSA-1483255 9.989810e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.990932e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.992173e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.992644e-01 0.000 0 0
Platelet homeostasis R-HSA-418346 9.993561e-01 0.000 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.993759e-01 0.000 0 0
Interleukin-10 signaling R-HSA-6783783 9.994629e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.994872e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.994872e-01 0.000 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.995047e-01 0.000 0 0
Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1638091 9.995587e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.996090e-01 0.000 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.996110e-01 0.000 0 0
Collagen degradation R-HSA-1442490 9.996498e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.997108e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.997147e-01 0.000 0 0
Xenobiotics R-HSA-211981 9.997524e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.997567e-01 0.000 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.997814e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.997852e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.998056e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.998250e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.998432e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.998815e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998898e-01 0.000 0 0
Metal ion assimilation from the host R-HSA-9638482 9.998898e-01 0.000 0 0
Metabolism of cofactors R-HSA-8978934 9.998898e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998898e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.999018e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999127e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999210e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.999221e-01 0.000 0 0
PPARA activates gene expression R-HSA-1989781 9.999274e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999422e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999422e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999534e-01 0.000 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.999563e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999653e-01 0.000 0 0
Biosynthesis of DHA-derived SPMs R-HSA-9018677 9.999653e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999717e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.999835e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.999872e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999917e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.999952e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.999957e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.999966e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.999970e-01 0.000 0 0
Keratinization R-HSA-6805567 9.999975e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999985e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999988e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999991e-01 0.000 0 0
Synthesis of substrates in N-glycan biosythesis R-HSA-446219 9.999992e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999997e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999998e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999999e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999999e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.999999e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999999e-01 0.000 0 0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446193 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678 1.000000e+00 0.000 0 0
Arachidonate metabolism R-HSA-2142753 1.000000e+00 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 1.000000e+00 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 1.000000e+00 0.000 0 0
GPCR downstream signalling R-HSA-388396 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Expression and translocation of olfactory receptors R-HSA-9752946 1.000000e+00 -0.000 0 0
Olfactory Signaling Pathway R-HSA-381753 1.000000e+00 -0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways