GAK

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
T Sites Probabilities
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
O14976 S26 Sugiyama GAK DNAJC26 sALDFLAGPGsLGGAsGRDQsDFVGQTVELGELRLRVRRVL
O14976 S399 Sugiyama GAK DNAJC26 RGGTERLFTNLKDTSSKVIQsVANyAKGDLDISyITSRIAV
O14976 T223 Sugiyama GAK DNAJC26 DYSWSAQRRALVEEEITRNTtPMYRtPEIIDLYSNFPIGEK
O14976 T228 Sugiyama GAK DNAJC26 AQRRALVEEEITRNTtPMYRtPEIIDLYSNFPIGEKQDIWA
O60664 T170 Sugiyama PLIN3 M6PRBP1 TIP47 AVDATRGAVQSGVDKTKsVVtGGVQsVMGsRLGQMVLsGVD
P04040 T29 Sugiyama CAT SDQMQHWKEQRAAQKADVLttGAGNPVGDKLNVItVGPRGP
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P07437 T55 Sugiyama TUBB TUBB5 OK/SW-cl.56 tyHGDsDLQLDRIsVyyNEAtGGKyVPRAILVDLEPGtMDs
P08238 T487 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB tsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVERVRKRG
P08865 T94 Sugiyama RPSA LAMBR LAMR1 VsVIssRNtGQRAVLKFAAAtGAtPIAGRFtPGTFTNQIQA
P09923 S111 Sugiyama ALPI DRFPYLALSKTYNVDRQVPDsAATATAYLCGVKANFQTIGL
P0DPH7 T56 Sugiyama TUBA3C TUBA2 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
P13639 T5 Sugiyama EEF2 EF2 ________________MVNFtVDQIRAIMDKKANIRNMsVI
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618 T45 Sugiyama PKM OIP3 PK2 PK3 PKM2 TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P23284 T81 Sugiyama PPIB CYPB IFGLFGKTVPKTVDNFVALAtGEKGFGYKNSKFHRVIKDFM
P29692 S162 Sugiyama EEF1D EF1D AKKPAtPAEDDEDDDIDLFGsDNEEEDKEAAQLREERLRQY
P29692 T147 Sugiyama EEF1D EF1D PQtQHVsPMRQVEPPAKKPAtPAEDDEDDDIDLFGsDNEEE
P30050 T18 Sugiyama RPL12 ___MPPKFDPNEIKVVYLRCtGGEVGAtsALAPKIGPLGLs
P37802 T190 Sugiyama TAGLN2 KIAA0120 CDABP0035 GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P46776 T95 Sugiyama RPL27A LDKLWtLVsEQtRVNAAKNKtGAAPIIDVVRsGyyKVLGKG
P49368 T430 Sugiyama CCT3 CCTG TRIC5 GGGASEMAVAHALTEKSKAMtGVEQWPyRAVAQALEVIPRT
P50990 T286 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 MNFsKGEENLMDAQVKAIADtGANVVVtGGKVADMALHYAN
P50990 T293 Sugiyama CCT8 C21orf112 CCTQ KIAA0002 ENLMDAQVKAIADtGANVVVtGGKVADMALHYANKYNIMLV
P62826 T21 Sugiyama RAN ARA24 OK/SW-cl.81 MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P68363 T56 Sugiyama TUBA1B MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
P68363 T82 Sugiyama TUBA1B VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q00610 T606 SIGNOR|PSP CLTC CLH17 CLTCL2 KIAA0034 EMNLMHAPQVADAILGNQMFtHYDRAHIAQLCEKAGLLQRA
Q58FF8 T263 Sugiyama HSP90AB2P HSP90BB FSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQVWKRD
Q6PEY2 T56 Sugiyama TUBA3E MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
Q71U36 T56 Sugiyama TUBA1A TUBA3 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q71U36 T82 Sugiyama TUBA1A TUBA3 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q8NFD5 S1744 Sugiyama ARID1B BAF250B DAN15 KIAA1235 OSA2 ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q9BQE3 T56 Sugiyama TUBA1C TUBA6 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q9BQE3 T82 Sugiyama TUBA1C TUBA6 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q9H3D4 T281 EPSD|PSP TP63 KET P63 P73H P73L TP73L PSHLIRVEGNSHAQYVEDPItGRQSVLVPyEPPQVGTEFTT
Q9H3D4 T46 EPSD|PSP TP63 KET P63 P73H P73L TP73L PAHFSWKESYYRSTMSQsTQtNEFLsPEVFQHIWDFLEQPI
Q9H3Z4 S10 Sugiyama DNAJC5 CLN4 ___________MADQRQRsLstsGEsLyHVLGLDKNATSDD
Q9H7D7 S121 Sugiyama WDR26 CDW2 MIP2 PRO0852 ASSSLATPELGSSLKKKKRLsQsDEDVIRLIGQHLNGLGLN
Q9UI15 T190 Sugiyama TAGLN3 NP25 GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9Y266 T145 Sugiyama NUDC AENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKLKPNLGN
Q9Y295 T62 Sugiyama DRG1 NEDD3 LITPKGGGGGGPGEGFDVAKtGDARIGFVGFPSVGKSTLLS
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 0.000002 5.705 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 0.000016 4.796 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 0.000019 4.711 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 0.000009 5.040 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 0.000011 4.961 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 0.000012 4.905 0 0
Separation of Sister Chromatids R-HSA-2467813 0.000016 4.808 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 0.000040 4.393 0 0
Cell junction organization R-HSA-446728 0.000046 4.341 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 0.000047 4.325 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 0.000061 4.214 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 0.000074 4.133 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 0.000074 4.133 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 0.000067 4.176 0 0
Aggrephagy R-HSA-9646399 0.000067 4.176 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 0.000105 3.977 0 0
Mitotic Prometaphase R-HSA-68877 0.000123 3.911 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 0.000125 3.902 0 0
Cell-Cell communication R-HSA-1500931 0.000126 3.901 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 0.000137 3.864 0 0
HCMV Early Events R-HSA-9609690 0.000147 3.831 0 0
Nuclear import of Rev protein R-HSA-180746 0.000148 3.830 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 0.000174 3.760 0 0
Mitotic Anaphase R-HSA-68882 0.000185 3.734 0 0
M Phase R-HSA-68886 0.000200 3.699 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 0.000195 3.710 0 0
Post NMDA receptor activation events R-HSA-438064 0.000245 3.611 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 0.000277 3.558 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 0.000275 3.561 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 0.000318 3.498 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 0.000356 3.449 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 0.000366 3.436 0 0
Signal Transduction R-HSA-162582 0.000392 3.406 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 0.000420 3.377 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 0.000480 3.319 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 0.000533 3.273 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 0.000564 3.249 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 0.000620 3.208 0 0
Cell-extracellular matrix interactions R-HSA-446353 0.000702 3.154 0 0
Nuclear Envelope Breakdown R-HSA-2980766 0.000702 3.154 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 0.000704 3.152 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 0.000743 3.129 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 0.000795 3.100 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 0.000863 3.064 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 0.000895 3.048 0 0
TGFBR3 expression R-HSA-9839394 0.001026 2.989 0 0
Recycling pathway of L1 R-HSA-437239 0.001005 2.998 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 0.001006 2.997 0 0
ISG15 antiviral mechanism R-HSA-1169408 0.001034 2.986 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 0.001091 2.962 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 0.001281 2.892 0 0
PCP/CE pathway R-HSA-4086400 0.001342 2.872 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 0.001338 2.874 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 0.001370 2.863 0 0
Cellular response to heat stress R-HSA-3371556 0.001507 2.822 0 0
Transport of connexons to the plasma membrane R-HSA-190872 0.001623 2.790 0 0
Axon guidance R-HSA-422475 0.001665 2.779 0 0
MHC class II antigen presentation R-HSA-2132295 0.001711 2.767 0 0
Signaling by Hedgehog R-HSA-5358351 0.001819 2.740 0 0
Host Interactions of HIV factors R-HSA-162909 0.001822 2.740 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 0.001879 2.726 0 0
PKMTs methylate histone lysines R-HSA-3214841 0.002017 2.695 0 0
Interferon Signaling R-HSA-913531 0.001934 2.713 0 0
COPI-mediated anterograde transport R-HSA-6807878 0.002062 2.686 0 0
Diseases of Telomere Maintenance R-HSA-9673013 0.002469 2.607 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 0.002469 2.607 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 0.002469 2.607 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 0.002469 2.607 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 0.002469 2.607 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 0.002469 2.607 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 0.002204 2.657 0 0
Signaling by AXIN mutants R-HSA-4839735 0.002296 2.639 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 0.002322 2.634 0 0
Amplification of signal from the kinetochores R-HSA-141424 0.002541 2.595 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 0.002541 2.595 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 0.002182 2.661 0 0
HCMV Infection R-HSA-9609646 0.002327 2.633 0 0
Chromatin organization R-HSA-4839726 0.002232 2.651 0 0
Nervous system development R-HSA-9675108 0.002558 2.592 0 0
Membrane Trafficking R-HSA-199991 0.002593 2.586 1 0
Hedgehog 'off' state R-HSA-5610787 0.002721 2.565 0 0
Deubiquitination R-HSA-5688426 0.002854 2.544 0 0
Pervasive developmental disorders R-HSA-9005895 0.002890 2.539 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 0.002890 2.539 0 0
Disorders of Nervous System Development R-HSA-9697154 0.002890 2.539 0 0
L1CAM interactions R-HSA-373760 0.003152 2.501 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 0.003167 2.499 0 0
Selective autophagy R-HSA-9663891 0.003167 2.499 0 0
ER to Golgi Anterograde Transport R-HSA-199977 0.003168 2.499 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 0.003204 2.494 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 0.003204 2.494 0 0
snRNP Assembly R-HSA-191859 0.003369 2.473 0 0
Metabolism of non-coding RNA R-HSA-194441 0.003369 2.473 0 0
Kinesins R-HSA-983189 0.003678 2.434 0 0
Apoptotic execution phase R-HSA-75153 0.003835 2.416 0 0
Signaling by TGFBR3 R-HSA-9839373 0.003835 2.416 0 0
Viral Messenger RNA Synthesis R-HSA-168325 0.004009 2.397 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 0.004362 2.360 0 0
tRNA processing in the nucleus R-HSA-6784531 0.004362 2.360 0 0
Nuclear Receptor transcription pathway R-HSA-383280 0.004536 2.343 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 0.004443 2.352 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 0.004573 2.340 0 0
Intraflagellar transport R-HSA-5620924 0.004656 2.332 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 0.004870 2.312 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 0.004870 2.312 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 0.004998 2.301 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 0.004998 2.301 0 0
PKR-mediated signaling R-HSA-9833482 0.005244 2.280 0 0
Cell-cell junction organization R-HSA-421270 0.005248 2.280 0 0
Loss of Function of SMAD4 in Cancer R-HSA-3304347 0.005426 2.266 0 0
SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 0.005426 2.266 0 0
SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 0.005426 2.266 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 0.005822 2.235 0 0
Cellular responses to stimuli R-HSA-8953897 0.005738 2.241 0 0
Cell Cycle R-HSA-1640170 0.006269 2.203 0 0
Inositol phosphate metabolism R-HSA-1483249 0.006112 2.214 0 0
Clathrin-mediated endocytosis R-HSA-8856828 0.006499 2.187 1 1
Adherens junctions interactions R-HSA-418990 0.006734 2.172 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 0.006877 2.163 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 0.007010 2.154 0 0
Disorders of Developmental Biology R-HSA-9675151 0.007457 2.127 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 0.009420 2.026 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 0.009420 2.026 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 0.009420 2.026 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 0.009420 2.026 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 0.009420 2.026 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 0.009420 2.026 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 0.009420 2.026 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 0.009420 2.026 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 0.009420 2.026 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 0.009420 2.026 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 0.009420 2.026 0 0
GP1b-IX-V activation signalling R-HSA-430116 0.009731 2.012 0 0
Translation initiation complex formation R-HSA-72649 0.007922 2.101 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 0.009316 2.031 0 0
Signaling by EGFR R-HSA-177929 0.009316 2.031 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 0.009316 2.031 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 0.009731 2.012 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 0.009372 2.028 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 0.009372 2.028 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 0.007695 2.114 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 0.009349 2.029 0 0
Mitotic Spindle Checkpoint R-HSA-69618 0.007879 2.104 0 0
Signaling by ROBO receptors R-HSA-376176 0.007765 2.110 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 0.008460 2.073 0 0
G2/M Transition R-HSA-69275 0.008584 2.066 0 0
Mitotic G2-G2/M phases R-HSA-453274 0.009316 2.031 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 0.009353 2.029 0 0
Cell Cycle, Mitotic R-HSA-69278 0.008913 2.050 0 0
Glycolysis R-HSA-70171 0.007879 2.104 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 0.010148 1.994 0 0
Mitotic Prophase R-HSA-68875 0.010487 1.979 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 0.010768 1.968 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 0.010782 1.967 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 0.010882 1.963 0 0
Cellular responses to stress R-HSA-2262752 0.011250 1.949 0 0
EGFR downregulation R-HSA-182971 0.011653 1.934 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 0.011653 1.934 0 0
Autophagy R-HSA-9612973 0.011815 1.928 0 0
Chromatin modifying enzymes R-HSA-3247509 0.012169 1.915 0 0
UCH proteinases R-HSA-5689603 0.012234 1.912 0 0
Gap junction trafficking R-HSA-190828 0.012254 1.912 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 0.014376 1.842 0 0
Signaling by APC mutants R-HSA-4839744 0.014662 1.834 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 0.014662 1.834 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 0.014662 1.834 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 0.014662 1.834 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 0.012938 1.888 0 0
Signaling by TGFB family members R-HSA-9006936 0.013991 1.854 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 0.014315 1.844 0 0
Signaling by WNT R-HSA-195721 0.012928 1.888 0 0
Macroautophagy R-HSA-1632852 0.013536 1.869 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 0.014315 1.844 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 0.014783 1.830 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 0.015618 1.806 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 0.015618 1.806 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 0.015720 1.804 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 0.017249 1.763 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 0.017249 1.763 0 0
Gap junction assembly R-HSA-190861 0.017357 1.761 0 0
Signaling by GSK3beta mutants R-HSA-5339716 0.017568 1.755 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 0.017568 1.755 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 0.017568 1.755 0 0
Signaling by AMER1 mutants R-HSA-4839748 0.017568 1.755 0 0
Cellular response to hypoxia R-HSA-1234174 0.017870 1.748 0 0
Gap junction trafficking and regulation R-HSA-157858 0.018351 1.736 0 0
AURKA Activation by TPX2 R-HSA-8854518 0.019077 1.719 0 0
HIV Infection R-HSA-162906 0.019247 1.716 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 0.019406 1.712 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 0.020219 1.694 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 0.020219 1.694 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 0.020219 1.694 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 0.020772 1.683 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 0.020772 1.683 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 0.020772 1.683 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 0.020772 1.683 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 0.020772 1.683 0 0
Formation of axial mesoderm R-HSA-9796292 0.024274 1.615 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 0.021723 1.663 0 0
Degradation of AXIN R-HSA-4641257 0.022676 1.644 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 0.024478 1.611 0 0
Cilium Assembly R-HSA-5617833 0.021394 1.670 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 0.023083 1.637 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 0.024478 1.611 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 0.023249 1.634 0 0
Glucose metabolism R-HSA-70326 0.022229 1.653 0 0
Chaperonin-mediated protein folding R-HSA-390466 0.024754 1.606 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 0.025976 1.585 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 0.026845 1.571 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 0.026845 1.571 0 0
IRS activation R-HSA-74713 0.026883 1.571 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 0.026883 1.571 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 0.026883 1.571 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 0.026883 1.571 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 0.026883 1.571 0 0
Regulation of MITF-M dependent genes involved in invasion R-HSA-9854909 0.026883 1.571 0 0
NrCAM interactions R-HSA-447038 0.026883 1.571 0 0
HIV Life Cycle R-HSA-162587 0.027095 1.567 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 0.029159 1.535 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 0.029159 1.535 0 0
Gene Silencing by RNA R-HSA-211000 0.030623 1.514 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 0.031262 1.505 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 0.032011 1.495 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 0.032173 1.493 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 0.032173 1.493 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 0.032173 1.493 0 0
Centrosome maturation R-HSA-380287 0.032595 1.487 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 0.032630 1.486 0 0
Protein folding R-HSA-391251 0.033557 1.474 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 0.033687 1.473 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 0.034300 1.465 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 0.034300 1.465 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 0.034300 1.465 0 0
Deletions in the AXIN1 gene destabilize the destruction complex R-HSA-5467345 0.035378 1.451 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 0.035378 1.451 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 0.042411 1.373 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 0.041249 1.385 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 0.039089 1.408 0 0
Neutrophil degranulation R-HSA-6798695 0.043277 1.364 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 0.044530 1.351 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 0.044279 1.354 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 0.041249 1.385 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 0.044530 1.351 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 0.038878 1.410 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 0.042411 1.373 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 0.042411 1.373 0 0
Gene expression (Transcription) R-HSA-74160 0.043180 1.365 0 0
Vesicle-mediated transport R-HSA-5653656 0.039477 1.404 1 0
Gastrulation R-HSA-9758941 0.042381 1.373 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 0.042411 1.373 0 0
Adaptive Immune System R-HSA-1280218 0.036164 1.442 0 0
SARS-CoV-2-host interactions R-HSA-9705683 0.038102 1.419 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 0.042353 1.373 0 0
Signaling by Hippo R-HSA-2028269 0.046219 1.335 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 0.046300 1.334 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 0.046732 1.330 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 0.047531 1.323 0 0
Cell Cycle Checkpoints R-HSA-69620 0.047685 1.322 0 0
Ub-specific processing proteases R-HSA-5689880 0.048573 1.314 0 0
SARS-CoV-2 Infection R-HSA-9694516 0.049073 1.309 0 0
Signaling by WNT in cancer R-HSA-4791275 0.050048 1.301 0 0
Death Receptor Signaling R-HSA-73887 0.050258 1.299 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 0.050649 1.295 0 0
MECP2 regulates transcription factors R-HSA-9022707 0.051156 1.291 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 0.051156 1.291 0 0
SOS-mediated signalling R-HSA-112412 0.051156 1.291 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 0.051156 1.291 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 0.051156 1.291 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 0.051470 1.288 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 0.051700 1.287 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 0.054038 1.267 0 0
Rap1 signalling R-HSA-392517 0.056996 1.244 0 0
Degradation of CDH1 R-HSA-9766229 0.057237 1.242 0 0
Response of endothelial cells to shear stress R-HSA-9860931 0.059372 1.226 0 0
Type I hemidesmosome assembly R-HSA-446107 0.060481 1.218 0 0
Signaling by NODAL R-HSA-1181150 0.062791 1.202 0 0
Negative regulation of MET activity R-HSA-6807004 0.062791 1.202 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 0.080666 1.093 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 0.080666 1.093 0 0
2-LTR circle formation R-HSA-164843 0.080666 1.093 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 0.080666 1.093 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 0.080666 1.093 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 0.075157 1.124 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 0.075157 1.124 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 0.067996 1.168 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 0.072805 1.138 0 0
Regulation of CDH11 function R-HSA-9762292 0.080666 1.093 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 0.080666 1.093 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 0.076469 1.117 0 0
PI3K/AKT activation R-HSA-198203 0.080666 1.093 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 0.064293 1.192 0 0
Signaling by VEGF R-HSA-194138 0.070042 1.155 0 0
Degradation of DVL R-HSA-4641258 0.076469 1.117 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 0.071814 1.144 1 1
mTORC1-mediated signalling R-HSA-166208 0.081713 1.088 0 0
TCF dependent signaling in response to WNT R-HSA-201681 0.065566 1.183 0 0
Signal attenuation R-HSA-74749 0.080666 1.093 0 0
ER-Phagosome pathway R-HSA-1236974 0.067015 1.174 0 0
Late Phase of HIV Life Cycle R-HSA-162599 0.067588 1.170 0 0
RUNX2 regulates bone development R-HSA-8941326 0.071658 1.145 0 0
RNA Polymerase II Transcription R-HSA-73857 0.076797 1.115 0 0
Organelle biogenesis and maintenance R-HSA-1852241 0.070749 1.150 0 0
Hedgehog 'on' state R-HSA-5632684 0.068665 1.163 0 0
Apoptosis R-HSA-109581 0.064818 1.188 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 0.075157 1.124 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 0.070334 1.153 0 0
TNF signaling R-HSA-75893 0.083959 1.076 0 0
Signaling by PDGFR in disease R-HSA-9671555 0.075157 1.124 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 0.081438 1.089 0 0
Signaling by Leptin R-HSA-2586552 0.080666 1.093 0 0
Disorders of transmembrane transporters R-HSA-5619115 0.063405 1.198 0 0
RET signaling R-HSA-8853659 0.071658 1.145 0 0
IRE1alpha activates chaperones R-HSA-381070 0.075808 1.120 0 0
SLC transporter disorders R-HSA-5619102 0.075183 1.124 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 0.086562 1.063 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 0.086562 1.063 0 0
Regulation of CDH1 Function R-HSA-9764561 0.088233 1.054 0 0
Synthesis of PA R-HSA-1483166 0.088233 1.054 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 0.088933 1.051 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 0.088960 1.051 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 0.091431 1.039 0 0
Formation of the posterior neural plate R-HSA-9832991 0.091431 1.039 0 0
Ionotropic activity of kainate receptors R-HSA-451306 0.091431 1.039 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 0.091839 1.037 0 0
Translation R-HSA-72766 0.095306 1.021 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 0.095527 1.020 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 0.095527 1.020 0 0
Deadenylation of mRNA R-HSA-429947 0.095527 1.020 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 0.097265 1.012 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 0.097265 1.012 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 0.098827 1.005 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 0.099604 1.002 0 0
Signaling by MET R-HSA-6806834 0.101410 0.994 0 0
SARS-CoV Infections R-HSA-9679506 0.102373 0.990 0 0
IKBKB deficiency causes SCID R-HSA-5602636 0.102430 0.990 0 0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) R-HSA-5619039 0.102430 0.990 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 0.102430 0.990 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 0.102430 0.990 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 0.102430 0.990 0 0
Defective VWF binding to collagen type I R-HSA-9845622 0.102430 0.990 0 0
Nef mediated downregulation of CD28 cell surface expression R-HSA-164939 0.102430 0.990 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 0.102586 0.989 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 0.102586 0.989 0 0
Integration of provirus R-HSA-162592 0.102586 0.989 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 0.102586 0.989 0 0
Long-term potentiation R-HSA-9620244 0.102768 0.988 0 0
HDMs demethylate histones R-HSA-3214842 0.102768 0.988 0 0
Sema4D in semaphorin signaling R-HSA-400685 0.102768 0.988 0 0
Estrogen-dependent gene expression R-HSA-9018519 0.105546 0.977 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 0.108554 0.964 0 0
MTOR signalling R-HSA-165159 0.108554 0.964 0 0
Enhanced cleavage of VWF variant by ADAMTS13 R-HSA-9845619 0.134191 0.872 0 0
Defective SLC12A1 causes Bartter syndrome 1 (BS1) R-HSA-5619104 0.134191 0.872 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 0.134191 0.872 0 0
Defective VWF cleavage by ADAMTS13 variant R-HSA-9845621 0.134191 0.872 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 0.134191 0.872 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 0.164829 0.783 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 0.164829 0.783 0 0
Invadopodia formation R-HSA-8941237 0.164829 0.783 0 0
MTF1 activates gene expression R-HSA-5660489 0.194385 0.711 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 0.194385 0.711 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 0.194385 0.711 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 0.194385 0.711 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 0.222897 0.652 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 0.222897 0.652 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 0.222897 0.652 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 0.114089 0.943 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 0.114089 0.943 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 0.250401 0.601 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 0.250401 0.601 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 0.250401 0.601 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 0.250401 0.601 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 0.250401 0.601 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 0.250401 0.601 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 0.125903 0.900 0 0
Retrograde neurotrophin signalling R-HSA-177504 0.137990 0.860 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 0.137990 0.860 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 0.276933 0.558 0 0
Erythropoietin activates STAT5 R-HSA-9027283 0.276933 0.558 0 0
Autointegration results in viral DNA circles R-HSA-177539 0.276933 0.558 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 0.276933 0.558 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 0.150317 0.823 0 0
IFNG signaling activates MAPKs R-HSA-9732724 0.302528 0.519 0 0
Recycling of eIF2:GDP R-HSA-72731 0.302528 0.519 0 0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis R-HSA-9632974 0.302528 0.519 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 0.302528 0.519 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 0.302528 0.519 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 0.302528 0.519 0 0
Disinhibition of SNARE formation R-HSA-114516 0.302528 0.519 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 0.302528 0.519 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 0.175565 0.756 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 0.175565 0.756 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 0.188427 0.725 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 0.188427 0.725 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 0.327219 0.485 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 0.327219 0.485 0 0
Formation of annular gap junctions R-HSA-196025 0.327219 0.485 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 0.327219 0.485 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 0.327219 0.485 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 0.133739 0.874 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 0.141936 0.848 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 0.227655 0.643 0 0
Striated Muscle Contraction R-HSA-390522 0.176257 0.754 0 0
Notch-HLH transcription pathway R-HSA-350054 0.267374 0.573 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 0.267374 0.573 0 0
Regulation of RAS by GAPs R-HSA-5658442 0.158983 0.799 0 0
mRNA 3'-end processing R-HSA-72187 0.172747 0.763 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 0.147751 0.830 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 0.320226 0.495 0 0
Signaling by RAF1 mutants R-HSA-9656223 0.259900 0.585 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 0.269539 0.569 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 0.146108 0.835 0 0
Signaling downstream of RAS mutants R-HSA-9649948 0.308410 0.511 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 0.270208 0.568 0 0
Cap-dependent Translation Initiation R-HSA-72737 0.192273 0.716 0 0
Formation of definitive endoderm R-HSA-9823730 0.227655 0.643 0 0
Eukaryotic Translation Initiation R-HSA-72613 0.192273 0.716 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 0.320226 0.495 0 0
Eukaryotic Translation Elongation R-HSA-156842 0.165595 0.781 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 0.164776 0.783 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 0.118187 0.927 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 0.308410 0.511 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 0.308410 0.511 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 0.191903 0.717 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 0.141936 0.848 0 0
MAP2K and MAPK activation R-HSA-5674135 0.259900 0.585 0 0
Signaling by ERBB2 R-HSA-1227986 0.231382 0.636 0 0
Oncogenic MAPK signaling R-HSA-6802957 0.246164 0.609 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 0.175565 0.756 0 0
GAB1 signalosome R-HSA-180292 0.201413 0.696 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 0.227655 0.643 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 0.172484 0.763 0 0
Signaling by RAS mutants R-HSA-6802949 0.308410 0.511 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 0.222897 0.652 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 0.150317 0.823 0 0
Trafficking of AMPA receptors R-HSA-399719 0.150296 0.823 0 0
Adipogenesis R-HSA-9843745 0.281548 0.550 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 0.318171 0.497 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 0.231299 0.636 0 0
Ribosome-associated quality control R-HSA-9948299 0.199984 0.699 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 0.222897 0.652 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 0.222897 0.652 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 0.125903 0.900 0 0
Activation of SMO R-HSA-5635838 0.162852 0.788 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 0.201413 0.696 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 0.185172 0.732 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 0.212574 0.672 0 0
Tight junction interactions R-HSA-420029 0.307071 0.513 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 0.146108 0.835 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 0.296816 0.528 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 0.118517 0.926 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 0.150317 0.823 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 0.162852 0.788 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 0.302528 0.519 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 0.110219 0.958 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 0.298659 0.525 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 0.307071 0.513 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 0.298659 0.525 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 0.175565 0.756 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 0.141936 0.848 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 0.114410 0.942 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 0.240868 0.618 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 0.141936 0.848 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 0.214496 0.669 0 0
Proteasome assembly R-HSA-9907900 0.120401 0.919 0 0
Germ layer formation at gastrulation R-HSA-9754189 0.214496 0.669 0 0
Signaling by BMP R-HSA-201451 0.117871 0.929 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 0.170619 0.768 0 0
Circadian clock R-HSA-9909396 0.169203 0.772 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 0.160807 0.794 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 0.134191 0.872 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 0.134191 0.872 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 0.134191 0.872 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 0.164829 0.783 0 0
MET interacts with TNS proteins R-HSA-8875513 0.164829 0.783 0 0
Reelin signalling pathway R-HSA-8866376 0.222897 0.652 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 0.250401 0.601 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 0.250401 0.601 0 0
Fibronectin matrix formation R-HSA-1566977 0.175565 0.756 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 0.125714 0.901 0 0
PKA activation R-HSA-163615 0.201413 0.696 0 0
PKA activation in glucagon signalling R-HSA-164378 0.201413 0.696 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 0.150296 0.823 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 0.126524 0.898 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 0.165814 0.780 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 0.293868 0.532 0 0
Diseases of Immune System R-HSA-5260271 0.240772 0.618 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 0.240772 0.618 0 0
Myogenesis R-HSA-525793 0.320226 0.495 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 0.223787 0.650 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 0.239040 0.622 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 0.308410 0.511 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 0.254525 0.594 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 0.153340 0.814 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 0.139152 0.857 0 0
Mitochondrial protein degradation R-HSA-9837999 0.321495 0.493 0 0
Co-inhibition by PD-1 R-HSA-389948 0.171753 0.765 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 0.327219 0.485 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 0.227655 0.643 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 0.164776 0.783 1 0
Regulation of insulin secretion R-HSA-422356 0.202849 0.693 0 0
Adrenoceptors R-HSA-390696 0.327219 0.485 0 0
Muscarinic acetylcholine receptors R-HSA-390648 0.222897 0.652 0 0
Signaling by Activin R-HSA-1502540 0.150317 0.823 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 0.302528 0.519 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 0.117871 0.929 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 0.298659 0.525 0 0
Interleukin-1 signaling R-HSA-9020702 0.113522 0.945 0 0
RAF/MAP kinase cascade R-HSA-5673001 0.229122 0.640 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 0.191903 0.717 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 0.294027 0.532 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 0.213590 0.670 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 0.253626 0.596 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 0.152749 0.816 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 0.164829 0.783 0 0
NADE modulates death signalling R-HSA-205025 0.194385 0.711 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 0.222897 0.652 0 0
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 0.250401 0.601 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 0.250401 0.601 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 0.276933 0.558 0 0
Protein methylation R-HSA-8876725 0.150317 0.823 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 0.188427 0.725 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 0.327219 0.485 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 0.125714 0.901 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 0.158809 0.799 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 0.167466 0.776 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 0.176257 0.754 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 0.194203 0.712 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 0.194203 0.712 0 0
MET promotes cell motility R-HSA-8875878 0.221897 0.654 0 0
Degradation of CRY and PER proteins R-HSA-9932298 0.259900 0.585 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 0.146108 0.835 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 0.318171 0.497 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 0.278112 0.556 0 0
Protein-protein interactions at synapses R-HSA-6794362 0.246164 0.609 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 0.211852 0.674 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 0.127063 0.896 0 0
HCMV Late Events R-HSA-9610379 0.184540 0.734 0 0
Metabolism of RNA R-HSA-8953854 0.147386 0.832 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 0.231382 0.636 0 0
Generic Transcription Pathway R-HSA-212436 0.109693 0.960 0 0
Early Phase of HIV Life Cycle R-HSA-162594 0.240868 0.618 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 0.250309 0.602 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 0.295492 0.529 0 0
ESR-mediated signaling R-HSA-8939211 0.324111 0.489 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 0.250401 0.601 0 0
Histamine receptors R-HSA-390650 0.164829 0.783 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 0.167466 0.776 0 0
Amine ligand-binding receptors R-HSA-375280 0.120401 0.919 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 0.201413 0.696 0 0
Interleukin-1 family signaling R-HSA-446652 0.164656 0.783 0 0
MAPK family signaling cascades R-HSA-5683057 0.178187 0.749 0 0
OAS antiviral response R-HSA-8983711 0.114089 0.943 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 0.267374 0.573 0 0
Hedgehog ligand biogenesis R-HSA-5358346 0.165814 0.780 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 0.116165 0.935 0 0
Signaling by PTK6 R-HSA-8848021 0.116165 0.935 0 0
Transmission across Chemical Synapses R-HSA-112315 0.180090 0.745 0 0
Calmodulin induced events R-HSA-111933 0.203340 0.692 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 0.227642 0.643 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 0.134191 0.872 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 0.164829 0.783 0 0
Dopamine receptors R-HSA-390651 0.194385 0.711 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 0.194385 0.711 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 0.222897 0.652 0 0
CLEC7A/inflammasome pathway R-HSA-5660668 0.250401 0.601 0 0
VEGF ligand-receptor interactions R-HSA-194313 0.250401 0.601 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 0.162852 0.788 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 0.240868 0.618 0 0
CaM pathway R-HSA-111997 0.203340 0.692 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 0.203340 0.692 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 0.203340 0.692 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 0.212574 0.672 0 0
Downstream TCR signaling R-HSA-202424 0.286778 0.542 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 0.272476 0.565 0 0
Programmed Cell Death R-HSA-5357801 0.193215 0.714 0 0
Antigen processing-Cross presentation R-HSA-1236975 0.146108 0.835 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 0.208406 0.681 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 0.277243 0.557 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 0.240868 0.618 0 0
Metabolism of proteins R-HSA-392499 0.241898 0.616 0 0
Ca-dependent events R-HSA-111996 0.269539 0.569 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 0.194203 0.712 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 0.212574 0.672 0 0
Ovarian tumor domain proteases R-HSA-5689896 0.212574 0.672 0 0
DAG and IP3 signaling R-HSA-1489509 0.298659 0.525 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 0.246756 0.608 0 0
Developmental Biology R-HSA-1266738 0.166783 0.778 0 0
Post-translational protein modification R-HSA-597592 0.170660 0.768 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 0.134191 0.872 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 0.222897 0.652 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 0.250401 0.601 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 0.250401 0.601 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 0.250401 0.601 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 0.125903 0.900 0 0
Formation of the anterior neural plate R-HSA-9823739 0.150317 0.823 0 0
Synthesis of PG R-HSA-1483148 0.175565 0.756 0 0
Protein hydroxylation R-HSA-9629569 0.227655 0.643 0 0
Vpu mediated degradation of CD4 R-HSA-180534 0.176257 0.754 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 0.185172 0.732 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 0.185172 0.732 0 0
Regulation of Apoptosis R-HSA-169911 0.194203 0.712 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 0.126524 0.898 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 0.126524 0.898 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 0.153340 0.814 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 0.207155 0.684 0 0
Regulation of TNFR1 signaling R-HSA-5357905 0.132776 0.877 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 0.250401 0.601 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 0.162852 0.788 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 0.167466 0.776 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 0.240772 0.618 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 0.250309 0.602 0 0
Viral Infection Pathways R-HSA-9824446 0.125536 0.901 0 0
SARS-CoV-1-host interactions R-HSA-9692914 0.137577 0.861 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 0.150317 0.823 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 0.302528 0.519 0 0
Maturation of nucleoprotein R-HSA-9694631 0.214496 0.669 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 0.221897 0.654 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 0.231299 0.636 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 0.288925 0.539 0 0
TCR signaling R-HSA-202403 0.278722 0.555 0 0
Syndecan interactions R-HSA-3000170 0.280631 0.552 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 0.260598 0.584 0 0
Signaling by ALK in cancer R-HSA-9700206 0.260598 0.584 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 0.302528 0.519 0 0
Synaptic adhesion-like molecules R-HSA-8849932 0.201413 0.696 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 0.307071 0.513 0 0
Influenza Infection R-HSA-168255 0.181876 0.740 0 0
MITF-M-dependent gene expression R-HSA-9856651 0.262384 0.581 0 0
HDL assembly R-HSA-8963896 0.137990 0.860 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 0.280631 0.552 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 0.267374 0.573 0 0
Formation of paraxial mesoderm R-HSA-9793380 0.239040 0.622 0 0
Unfolded Protein Response (UPR) R-HSA-381119 0.114962 0.939 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 0.122586 0.912 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 0.254525 0.594 0 0
Cytokine Signaling in Immune system R-HSA-1280215 0.300712 0.522 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 0.326163 0.487 0 0
tRNA processing R-HSA-72306 0.245275 0.610 0 0
Stabilization of p53 R-HSA-69541 0.231299 0.636 0 0
XBP1(S) activates chaperone genes R-HSA-381038 0.131620 0.881 0 0
Plasma lipoprotein assembly R-HSA-8963898 0.293868 0.532 0 0
Somitogenesis R-HSA-9824272 0.298659 0.525 0 0
Interleukin-7 signaling R-HSA-1266695 0.307071 0.513 0 0
Growth hormone receptor signaling R-HSA-982772 0.280631 0.552 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 0.327937 0.484 0 0
GPER1 signaling R-HSA-9634597 0.327937 0.484 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 0.327937 0.484 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 0.333318 0.477 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 0.335523 0.474 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 0.337700 0.471 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 0.337700 0.471 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 0.340854 0.467 0 0
Signaling by NOTCH4 R-HSA-9013694 0.342321 0.466 0 0
Cellular response to chemical stress R-HSA-9711123 0.345697 0.461 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 0.351036 0.455 0 0
WNT mediated activation of DVL R-HSA-201688 0.351036 0.455 0 0
Gap junction degradation R-HSA-190873 0.351036 0.455 0 0
ALK mutants bind TKIs R-HSA-9700645 0.351036 0.455 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 0.351036 0.455 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 0.351036 0.455 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 0.351036 0.455 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 0.351036 0.455 0 0
Regulation of signaling by NODAL R-HSA-1433617 0.351036 0.455 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 0.351036 0.455 0 0
Regulated proteolysis of p75NTR R-HSA-193692 0.351036 0.455 0 0
Interleukin-1 processing R-HSA-448706 0.351036 0.455 0 0
Cellular response to mitochondrial stress R-HSA-9840373 0.351036 0.455 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 0.351036 0.455 0 0
Post-translational protein phosphorylation R-HSA-8957275 0.356655 0.448 0 0
DARPP-32 events R-HSA-180024 0.359270 0.445 0 0
FOXO-mediated transcription R-HSA-9614085 0.363712 0.439 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 0.366916 0.435 0 0
Orc1 removal from chromatin R-HSA-68949 0.366916 0.435 0 0
ABC-family proteins mediated transport R-HSA-382556 0.370773 0.431 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 0.372108 0.429 0 0
Interleukin-37 signaling R-HSA-9008059 0.372108 0.429 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 0.374012 0.427 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 0.374012 0.427 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 0.374012 0.427 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 0.374012 0.427 0 0
Josephin domain DUBs R-HSA-5689877 0.374012 0.427 0 0
G alpha (12/13) signalling events R-HSA-416482 0.374672 0.426 0 0
ABC transporter disorders R-HSA-5619084 0.374672 0.426 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 0.376610 0.424 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 0.376610 0.424 0 0
Regulation of PTEN stability and activity R-HSA-8948751 0.376610 0.424 0 0
G alpha (s) signalling events R-HSA-418555 0.377832 0.423 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 0.382746 0.417 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 0.384842 0.415 0 0
PI Metabolism R-HSA-1483255 0.384893 0.415 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 0.386274 0.413 0 0
Signaling by NOTCH3 R-HSA-9012852 0.395902 0.402 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 0.395902 0.402 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 0.396176 0.402 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 0.396176 0.402 0 0
Bicarbonate transporters R-HSA-425381 0.396176 0.402 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 0.396176 0.402 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 0.396176 0.402 0 0
Diseases of mitotic cell cycle R-HSA-9675126 0.397462 0.401 0 0
SARS-CoV-1 Infection R-HSA-9678108 0.399413 0.399 0 0
Neuronal System R-HSA-112316 0.401003 0.397 0 0
NRAGE signals death through JNK R-HSA-193648 0.405490 0.392 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 0.405490 0.392 0 0
Integrin signaling R-HSA-354192 0.409960 0.387 0 0
Nuclear RNA decay R-HSA-9930044 0.409960 0.387 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 0.414893 0.382 0 0
Cytoprotection by HMOX1 R-HSA-9707564 0.414893 0.382 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 0.417557 0.379 0 0
NF-kB is activated and signals survival R-HSA-209560 0.417557 0.379 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 0.417557 0.379 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 0.417557 0.379 0 0
Anchoring fibril formation R-HSA-2214320 0.417557 0.379 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 0.417557 0.379 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 0.417557 0.379 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 0.417557 0.379 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 0.422331 0.374 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 0.422331 0.374 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 0.424525 0.372 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 0.427090 0.369 0 0
Intracellular signaling by second messengers R-HSA-9006925 0.431239 0.365 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 0.433965 0.363 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 0.433965 0.363 0 0
Triglyceride metabolism R-HSA-8979227 0.433965 0.363 0 0
Stimuli-sensing channels R-HSA-2672351 0.434077 0.362 0 0
NOD1/2 Signaling Pathway R-HSA-168638 0.434566 0.362 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 0.434566 0.362 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 0.438182 0.358 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 0.438182 0.358 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 0.438182 0.358 0 0
GRB2 events in EGFR signaling R-HSA-179812 0.438182 0.358 0 0
VLDLR internalisation and degradation R-HSA-8866427 0.438182 0.358 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 0.438182 0.358 0 0
Signaling by LTK R-HSA-9842663 0.438182 0.358 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 0.438182 0.358 0 0
IRAK1 recruits IKK complex R-HSA-937039 0.438182 0.358 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 0.438182 0.358 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 0.438182 0.358 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 0.438182 0.358 0 0
Developmental Cell Lineages R-HSA-9734767 0.441320 0.355 0 0
Metabolism of polyamines R-HSA-351202 0.443346 0.353 0 0
PERK regulates gene expression R-HSA-381042 0.446660 0.350 0 0
Oncogene Induced Senescence R-HSA-2559585 0.446660 0.350 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 0.448401 0.348 0 0
Aquaporin-mediated transport R-HSA-445717 0.452666 0.344 0 0
PLC beta mediated events R-HSA-112043 0.452666 0.344 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 0.452666 0.344 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 0.458077 0.339 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 0.458077 0.339 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 0.458077 0.339 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 0.458077 0.339 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 0.458077 0.339 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 0.458077 0.339 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 0.458608 0.339 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 0.458608 0.339 0 0
HSF1 activation R-HSA-3371511 0.458608 0.339 0 0
RNA Polymerase III Transcription R-HSA-74158 0.458608 0.339 0 0
Triglyceride catabolism R-HSA-163560 0.458608 0.339 0 0
Regulation of TP53 Degradation R-HSA-6804757 0.458608 0.339 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 0.461821 0.336 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 0.461821 0.336 0 0
Heme signaling R-HSA-9707616 0.461921 0.335 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 0.461921 0.335 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 0.462426 0.335 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 0.470404 0.328 0 0
Collagen chain trimerization R-HSA-8948216 0.470404 0.328 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 0.471108 0.327 0 0
Semaphorin interactions R-HSA-373755 0.471108 0.327 0 0
Integration of energy metabolism R-HSA-163685 0.473344 0.325 0 0
NRIF signals cell death from the nucleus R-HSA-205043 0.477269 0.321 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 0.477269 0.321 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 0.477269 0.321 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 0.477269 0.321 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 0.477269 0.321 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 0.477269 0.321 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 0.477269 0.321 0 0
Regulation of KIT signaling R-HSA-1433559 0.477269 0.321 0 0
Non-canonical inflammasome activation R-HSA-9686114 0.477269 0.321 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 0.479532 0.319 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 0.480223 0.319 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 0.482367 0.317 0 0
PTEN Regulation R-HSA-6807070 0.491841 0.308 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 0.493527 0.307 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 0.493527 0.307 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 0.495783 0.305 0 0
Erythropoietin activates RAS R-HSA-9027284 0.495783 0.305 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 0.495783 0.305 0 0
SHC1 events in EGFR signaling R-HSA-180336 0.495783 0.305 0 0
G beta:gamma signalling through BTK R-HSA-8964315 0.495783 0.305 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 0.495783 0.305 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 0.495783 0.305 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 0.495783 0.305 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 0.495783 0.305 0 0
p75NTR signals via NF-kB R-HSA-193639 0.495783 0.305 0 0
Immune System R-HSA-168256 0.499546 0.301 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 0.500824 0.300 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 0.504847 0.297 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 0.504847 0.297 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 0.504847 0.297 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 0.504847 0.297 0 0
Glycogen metabolism R-HSA-8982491 0.504847 0.297 0 0
DNA Double Strand Break Response R-HSA-5693606 0.507110 0.295 0 0
G-protein mediated events R-HSA-112040 0.507110 0.295 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 0.513642 0.289 0 0
Killing mechanisms R-HSA-9664420 0.513642 0.289 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 0.513642 0.289 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 0.513642 0.289 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 0.513642 0.289 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 0.513642 0.289 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 0.513642 0.289 0 0
Attachment and Entry R-HSA-9678110 0.513642 0.289 0 0
Negative regulation of FLT3 R-HSA-9706369 0.513642 0.289 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 0.515882 0.287 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 0.516001 0.287 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 0.523331 0.281 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 0.526987 0.278 0 0
FCERI mediated NF-kB activation R-HSA-2871837 0.528153 0.277 0 0
Asparagine N-linked glycosylation R-HSA-446203 0.530216 0.276 0 0
Formation of a pool of free 40S subunits R-HSA-72689 0.530725 0.275 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 0.530870 0.275 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 0.530870 0.275 0 0
Galactose catabolism R-HSA-70370 0.530870 0.275 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 0.530870 0.275 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 0.530870 0.275 0 0
Response to metal ions R-HSA-5660526 0.530870 0.275 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 0.530870 0.275 0 0
COPII-mediated vesicle transport R-HSA-204005 0.533255 0.273 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 0.533255 0.273 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 0.537803 0.269 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 0.537803 0.269 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 0.541794 0.266 0 0
Regulation of mitotic cell cycle R-HSA-453276 0.541794 0.266 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 0.547488 0.262 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 0.547488 0.262 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 0.547488 0.262 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 0.547488 0.262 0 0
TBC/RABGAPs R-HSA-8854214 0.548448 0.261 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 0.550244 0.259 0 0
Ca2+ pathway R-HSA-4086398 0.558600 0.253 0 0
Switching of origins to a post-replicative state R-HSA-69052 0.558600 0.253 0 0
HATs acetylate histones R-HSA-3214847 0.559720 0.252 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 0.563518 0.249 0 0
Ephrin signaling R-HSA-3928664 0.563518 0.249 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 0.563518 0.249 0 0
Presynaptic function of Kainate receptors R-HSA-500657 0.563518 0.249 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 0.563518 0.249 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 0.563518 0.249 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 0.563518 0.249 0 0
Chaperone Mediated Autophagy R-HSA-9613829 0.563518 0.249 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 0.563518 0.249 0 0
Apoptotic factor-mediated response R-HSA-111471 0.563518 0.249 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 0.563518 0.249 0 0
Nephron development R-HSA-9831926 0.563518 0.249 0 0
Signaling by ERBB4 R-HSA-1236394 0.566862 0.247 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 0.575029 0.240 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 0.575029 0.240 0 0
Cellular Senescence R-HSA-2559583 0.576008 0.240 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 0.578982 0.237 0 0
Crosslinking of collagen fibrils R-HSA-2243919 0.578982 0.237 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 0.578982 0.237 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 0.578982 0.237 0 0
Translesion Synthesis by POLH R-HSA-110320 0.578982 0.237 0 0
Diseases of hemostasis R-HSA-9671793 0.578982 0.237 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 0.578982 0.237 0 0
Other interleukin signaling R-HSA-449836 0.578982 0.237 0 0
The NLRP3 inflammasome R-HSA-844456 0.578982 0.237 0 0
STING mediated induction of host immune responses R-HSA-1834941 0.578982 0.237 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 0.579338 0.237 0 0
Epigenetic regulation of gene expression R-HSA-212165 0.579874 0.237 0 0
Platelet degranulation R-HSA-114608 0.580221 0.236 0 0
G2/M Checkpoints R-HSA-69481 0.580221 0.236 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 0.580817 0.236 0 0
PIP3 activates AKT signaling R-HSA-1257604 0.582208 0.235 0 0
Phospholipid metabolism R-HSA-1483257 0.582208 0.235 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 0.586394 0.232 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 0.589285 0.230 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 0.591072 0.228 0 0
Translation of Structural Proteins R-HSA-9694635 0.591072 0.228 0 0
PPARA activates gene expression R-HSA-1989781 0.591721 0.228 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 0.593899 0.226 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 0.593899 0.226 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 0.593899 0.226 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 0.593899 0.226 0 0
Pregnenolone biosynthesis R-HSA-196108 0.593899 0.226 0 0
Signal transduction by L1 R-HSA-445144 0.593899 0.226 0 0
Nephrin family interactions R-HSA-373753 0.593899 0.226 0 0
Glycogen synthesis R-HSA-3322077 0.593899 0.226 0 0
Opioid Signalling R-HSA-111885 0.594555 0.226 0 0
Integrin cell surface interactions R-HSA-216083 0.598945 0.223 0 0
Activation of HOX genes during differentiation R-HSA-5619507 0.601323 0.221 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 0.601323 0.221 0 0
RSV-host interactions R-HSA-9833110 0.601323 0.221 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 0.602791 0.220 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 0.608023 0.216 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 0.608265 0.216 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 0.608288 0.216 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 0.608288 0.216 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 0.608288 0.216 0 0
G-protein activation R-HSA-202040 0.608288 0.216 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 0.608288 0.216 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 0.608288 0.216 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 0.608288 0.216 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 0.608288 0.216 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 0.608288 0.216 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 0.608288 0.216 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 0.608288 0.216 0 0
Vitamin C (ascorbate) metabolism R-HSA-196836 0.608288 0.216 0 0
Basigin interactions R-HSA-210991 0.608288 0.216 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 0.608650 0.216 0 0
Interferon gamma signaling R-HSA-877300 0.613697 0.212 0 0
Platelet activation, signaling and aggregation R-HSA-76002 0.615020 0.211 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 0.617069 0.210 0 0
PI3K Cascade R-HSA-109704 0.618070 0.209 0 0
Regulation of TP53 Activity R-HSA-5633007 0.619088 0.208 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 0.621963 0.206 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 0.622168 0.206 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 0.622168 0.206 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 0.622168 0.206 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 0.622168 0.206 0 0
Attachment and Entry R-HSA-9694614 0.622168 0.206 0 0
Signaling by Nuclear Receptors R-HSA-9006931 0.623263 0.205 0 0
HSF1-dependent transactivation R-HSA-3371571 0.627314 0.203 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 0.635557 0.197 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 0.635557 0.197 0 0
LDL clearance R-HSA-8964038 0.635557 0.197 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 0.635557 0.197 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 0.636383 0.196 0 0
Neurexins and neuroligins R-HSA-6794361 0.636383 0.196 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 0.636383 0.196 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 0.636383 0.196 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 0.640468 0.194 0 0
MyD88-independent TLR4 cascade R-HSA-166166 0.640468 0.194 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 0.645278 0.190 0 0
Smooth Muscle Contraction R-HSA-445355 0.645278 0.190 0 0
Amino acids regulate mTORC1 R-HSA-9639288 0.645278 0.190 0 0
Meiotic synapsis R-HSA-1221632 0.645278 0.190 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 0.648473 0.188 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 0.648473 0.188 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 0.648473 0.188 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 0.648473 0.188 0 0
Interleukin receptor SHC signaling R-HSA-912526 0.648473 0.188 0 0
Carnitine shuttle R-HSA-200425 0.648473 0.188 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 0.648473 0.188 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 0.654001 0.184 0 0
Thromboxane signalling through TP receptor R-HSA-428930 0.660931 0.180 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 0.660931 0.180 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 0.660931 0.180 0 0
Mitochondrial RNA degradation R-HSA-9836573 0.660931 0.180 0 0
HDACs deacetylate histones R-HSA-3214815 0.662552 0.179 0 0
G alpha (z) signalling events R-HSA-418597 0.662552 0.179 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 0.665236 0.177 0 0
Ion homeostasis R-HSA-5578775 0.670932 0.173 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 0.670932 0.173 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 0.670932 0.173 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 0.672949 0.172 0 0
G protein gated Potassium channels R-HSA-1296059 0.672949 0.172 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 0.672949 0.172 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 0.675462 0.170 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 0.677018 0.169 0 0
Peptide chain elongation R-HSA-156902 0.678834 0.168 0 0
IRS-mediated signalling R-HSA-112399 0.679142 0.168 0 0
Signaling by EGFR in Cancer R-HSA-1643713 0.684541 0.165 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 0.684541 0.165 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 0.684541 0.165 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 0.684541 0.165 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 0.684541 0.165 0 0
MET activates PTK2 signaling R-HSA-8874081 0.684541 0.165 0 0
Metalloprotease DUBs R-HSA-5689901 0.684541 0.165 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 0.684541 0.165 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 0.687185 0.163 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 0.687835 0.163 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 0.692019 0.160 0 0
Rab regulation of trafficking R-HSA-9007101 0.694296 0.158 0 0
Mitochondrial biogenesis R-HSA-1592230 0.694296 0.158 0 0
Peroxisomal protein import R-HSA-9033241 0.695061 0.158 0 0
Interaction between L1 and Ankyrins R-HSA-445095 0.695723 0.158 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 0.695723 0.158 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 0.695723 0.158 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 0.695723 0.158 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 0.695723 0.158 0 0
Cristae formation R-HSA-8949613 0.695723 0.158 0 0
Triglyceride biosynthesis R-HSA-75109 0.695723 0.158 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 0.695723 0.158 0 0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 0.695723 0.158 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 0.695723 0.158 0 0
Maturation of hRSV A proteins R-HSA-9828806 0.695723 0.158 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 0.695723 0.158 0 0
Insulin processing R-HSA-264876 0.695723 0.158 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 0.702773 0.153 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 0.702773 0.153 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 0.702773 0.153 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 0.702773 0.153 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 0.702773 0.153 0 0
Regulation of PTEN gene transcription R-HSA-8943724 0.702773 0.153 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 0.705443 0.152 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 0.705443 0.152 0 0
HIV elongation arrest and recovery R-HSA-167287 0.706510 0.151 0 0
Pausing and recovery of HIV elongation R-HSA-167290 0.706510 0.151 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 0.706510 0.151 0 0
Formation of the Early Elongation Complex R-HSA-113418 0.706510 0.151 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 0.706510 0.151 0 0
Pyroptosis R-HSA-5620971 0.706510 0.151 0 0
Inflammasomes R-HSA-622312 0.706510 0.151 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 0.710322 0.149 0 0
Collagen degradation R-HSA-1442490 0.710322 0.149 0 0
MAP kinase activation R-HSA-450294 0.710322 0.149 0 0
EPH-Ephrin signaling R-HSA-2682334 0.711025 0.148 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 0.711025 0.148 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 0.713506 0.147 0 0
S Phase R-HSA-69242 0.713506 0.147 0 0
Signaling by NTRKs R-HSA-166520 0.713506 0.147 0 0
Signaling by Erythropoietin R-HSA-9006335 0.716915 0.145 0 0
Glucagon-type ligand receptors R-HSA-420092 0.716915 0.145 0 0
Assembly of the pre-replicative complex R-HSA-68867 0.717157 0.144 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 0.717711 0.144 0 0
Signaling by NOTCH R-HSA-157118 0.719124 0.143 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 0.721607 0.142 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 0.721607 0.142 0 0
Collagen formation R-HSA-1474290 0.723187 0.141 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 0.726847 0.139 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 0.726951 0.138 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 0.726951 0.138 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 0.726951 0.138 0 0
Activation of BH3-only proteins R-HSA-114452 0.726951 0.138 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 0.729117 0.137 0 0
Muscle contraction R-HSA-397014 0.730072 0.137 0 0
IGF1R signaling cascade R-HSA-2428924 0.732012 0.135 0 0
Insulin receptor signalling cascade R-HSA-74751 0.732012 0.135 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 0.732527 0.135 0 0
Budding and maturation of HIV virion R-HSA-162588 0.736632 0.133 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 0.736632 0.133 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 0.736632 0.133 0 0
Cargo concentration in the ER R-HSA-5694530 0.736632 0.133 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 0.736632 0.133 0 0
Downstream signal transduction R-HSA-186763 0.736632 0.133 0 0
DNA Double-Strand Break Repair R-HSA-5693532 0.737136 0.132 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 0.738929 0.131 0 0
Hemostasis R-HSA-109582 0.742093 0.130 0 0
Inwardly rectifying K+ channels R-HSA-1296065 0.745971 0.127 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 0.751842 0.124 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 0.751842 0.124 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 0.751842 0.124 0 0
Infectious disease R-HSA-5663205 0.753749 0.123 0 0
G-protein beta:gamma signalling R-HSA-397795 0.754979 0.122 0 0
FGFR1 mutant receptor activation R-HSA-1839124 0.754979 0.122 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 0.754979 0.122 0 0
Recycling of bile acids and salts R-HSA-159418 0.754979 0.122 0 0
Cardiogenesis R-HSA-9733709 0.754979 0.122 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 0.754979 0.122 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 0.758771 0.120 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 0.758771 0.120 0 0
Cellular response to starvation R-HSA-9711097 0.759313 0.120 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 0.763668 0.117 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 0.763668 0.117 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 0.763668 0.117 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 0.766132 0.116 0 0
Interleukin-17 signaling R-HSA-448424 0.771263 0.113 0 0
RAF activation R-HSA-5673000 0.772049 0.112 0 0
Signal amplification R-HSA-392518 0.772049 0.112 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 0.772049 0.112 0 0
Mitophagy R-HSA-5205647 0.772049 0.112 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 0.772049 0.112 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 0.772049 0.112 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 0.772049 0.112 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 0.772049 0.112 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 0.772049 0.112 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 0.772049 0.112 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 0.777295 0.109 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 0.783031 0.106 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 0.783188 0.106 0 0
GPVI-mediated activation cascade R-HSA-114604 0.787933 0.104 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 0.787933 0.104 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 0.794563 0.100 0 0
G2/M DNA damage checkpoint R-HSA-69473 0.794563 0.100 0 0
Voltage gated Potassium channels R-HSA-1296072 0.795455 0.099 0 0
SLC-mediated transport of organic cations R-HSA-549127 0.795455 0.099 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 0.795455 0.099 0 0
Metabolism of folate and pterines R-HSA-196757 0.795455 0.099 0 0
Protein ubiquitination R-HSA-8852135 0.800051 0.097 0 0
Synthesis of DNA R-HSA-69239 0.801973 0.096 0 0
G alpha (q) signalling events R-HSA-416476 0.802124 0.096 0 0
rRNA processing R-HSA-72312 0.802257 0.096 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 0.805409 0.094 0 0
Signaling by NOTCH1 R-HSA-1980143 0.805409 0.094 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 0.806486 0.093 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 0.809710 0.092 0 0
Plasma lipoprotein clearance R-HSA-8964043 0.809710 0.092 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 0.809710 0.092 0 0
Pentose phosphate pathway R-HSA-71336 0.809710 0.092 0 0
Signaling by ALK R-HSA-201556 0.809710 0.092 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 0.809710 0.092 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 0.810305 0.091 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 0.810912 0.091 0 0
DNA Replication Pre-Initiation R-HSA-69002 0.810912 0.091 0 0
Extracellular matrix organization R-HSA-1474244 0.812190 0.090 0 0
RNA Polymerase I Transcription R-HSA-73864 0.815742 0.088 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 0.816461 0.088 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 0.816461 0.088 0 0
HIV Transcription Elongation R-HSA-167169 0.816461 0.088 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 0.816461 0.088 0 0
Attenuation phase R-HSA-3371568 0.816461 0.088 0 0
Generation of second messenger molecules R-HSA-202433 0.816461 0.088 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 0.816461 0.088 0 0
Interleukin-2 family signaling R-HSA-451927 0.816461 0.088 0 0
Sensory processing of sound R-HSA-9659379 0.820722 0.086 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 0.822973 0.085 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 0.822973 0.085 0 0
Maturation of spike protein R-HSA-9694548 0.822973 0.085 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 0.822973 0.085 0 0
FLT3 Signaling R-HSA-9607240 0.822973 0.085 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 0.827771 0.082 0 0
Intra-Golgi traffic R-HSA-6811438 0.829254 0.081 0 0
Negative regulation of MAPK pathway R-HSA-5675221 0.829254 0.081 0 0
Signaling by FGFR1 in disease R-HSA-5655302 0.829254 0.081 0 0
Scavenging by Class A Receptors R-HSA-3000480 0.829254 0.081 0 0
Processing of DNA double-strand break ends R-HSA-5693607 0.830323 0.081 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 0.834947 0.078 0 0
Activation of GABAB receptors R-HSA-991365 0.835313 0.078 0 0
GABA B receptor activation R-HSA-977444 0.835313 0.078 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 0.835313 0.078 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 0.839555 0.076 0 0
Signaling by SCF-KIT R-HSA-1433557 0.841157 0.075 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 0.843856 0.074 0 0
RMTs methylate histone arginines R-HSA-3214858 0.846794 0.072 0 0
Meiosis R-HSA-1500620 0.848145 0.072 0 0
Peptide hormone metabolism R-HSA-2980736 0.850637 0.070 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 0.852232 0.069 0 0
Nucleosome assembly R-HSA-774815 0.852232 0.069 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 0.852232 0.069 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 0.852327 0.069 0 0
Homology Directed Repair R-HSA-5693538 0.854181 0.068 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 0.856403 0.067 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 0.856403 0.067 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 0.857476 0.067 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 0.857476 0.067 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 0.857476 0.067 0 0
Protein localization R-HSA-9609507 0.863824 0.064 0 0
DNA Replication R-HSA-69306 0.863824 0.064 0 0
Chromosome Maintenance R-HSA-73886 0.864373 0.063 0 0
Neddylation R-HSA-8951664 0.865406 0.063 0 0
NGF-stimulated transcription R-HSA-9031628 0.867415 0.062 0 0
Co-stimulation by CD28 R-HSA-389356 0.867415 0.062 0 0
Ion channel transport R-HSA-983712 0.868994 0.061 0 0
DNA Damage Bypass R-HSA-73893 0.872122 0.059 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 0.872122 0.059 0 0
Formation of the cornified envelope R-HSA-6809371 0.873935 0.059 0 0
Toll-like Receptor Cascades R-HSA-168898 0.874172 0.058 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 0.875284 0.058 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 0.875284 0.058 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 0.875807 0.058 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 0.878774 0.056 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 0.879973 0.056 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 0.879973 0.056 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 0.879973 0.056 0 0
G1/S Transition R-HSA-69206 0.879973 0.056 0 0
Complex IV assembly R-HSA-9864848 0.881041 0.055 0 0
The phototransduction cascade R-HSA-2514856 0.881041 0.055 0 0
Signaling by Insulin receptor R-HSA-74752 0.882175 0.054 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 0.885264 0.053 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 0.885264 0.053 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 0.889338 0.051 0 0
Innate Immune System R-HSA-168249 0.890441 0.050 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 0.892176 0.050 0 0
Eukaryotic Translation Termination R-HSA-72764 0.894913 0.048 0 0
Potassium Channels R-HSA-1296071 0.897891 0.047 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 0.900714 0.045 0 0
Telomere Maintenance R-HSA-157579 0.900790 0.045 0 0
Degradation of the extracellular matrix R-HSA-1474228 0.901631 0.045 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 0.904241 0.044 0 0
mRNA Splicing R-HSA-72172 0.905768 0.043 0 0
Synthesis of bile acids and bile salts R-HSA-192105 0.906361 0.043 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 0.907642 0.042 0 0
Regulation of beta-cell development R-HSA-186712 0.910923 0.041 0 0
Amino acid transport across the plasma membrane R-HSA-352230 0.910923 0.041 0 0
Selenocysteine synthesis R-HSA-2408557 0.911637 0.040 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 0.911637 0.040 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 0.914087 0.039 0 0
GABA receptor activation R-HSA-977443 0.914087 0.039 0 0
Signaling by Retinoic Acid R-HSA-5362517 0.914087 0.039 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 0.914087 0.039 0 0
tRNA Aminoacylation R-HSA-379724 0.914087 0.039 0 0
Regulation of endogenous retroelements R-HSA-9842860 0.914170 0.039 0 0
Viral mRNA Translation R-HSA-192823 0.916635 0.038 0 0
Endogenous sterols R-HSA-211976 0.917139 0.038 0 0
Mitochondrial protein import R-HSA-1268020 0.920083 0.036 0 0
Signaling by PDGF R-HSA-186797 0.920083 0.036 0 0
Nucleotide Excision Repair R-HSA-5696398 0.923635 0.034 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 0.930851 0.031 0 0
SLC-mediated transport of amino acids R-HSA-9958863 0.933308 0.030 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 0.933308 0.030 0 0
Metabolism of steroid hormones R-HSA-196071 0.933308 0.030 0 0
Kidney development R-HSA-9830369 0.933308 0.030 0 0
Bile acid and bile salt metabolism R-HSA-194068 0.934087 0.030 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 0.934694 0.029 0 0
Transcription of the HIV genome R-HSA-167172 0.935678 0.029 0 0
Regulated Necrosis R-HSA-5218859 0.935678 0.029 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 0.939692 0.027 0 0
Potential therapeutics for SARS R-HSA-9679191 0.941182 0.026 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 0.941458 0.026 0 0
ECM proteoglycans R-HSA-3000178 0.942296 0.026 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 0.942296 0.026 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 0.942296 0.026 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 0.944348 0.025 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 0.945284 0.024 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 0.946465 0.024 0 0
Interferon alpha/beta signaling R-HSA-909733 0.946465 0.024 0 0
Signaling by FGFR in disease R-HSA-1226099 0.948235 0.023 0 0
mRNA Splicing - Major Pathway R-HSA-72163 0.948286 0.023 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 0.950075 0.022 0 0
Cell surface interactions at the vascular wall R-HSA-202733 0.954326 0.020 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 0.955214 0.020 0 0
Signaling by Interleukins R-HSA-449147 0.956502 0.019 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 0.958343 0.018 0 0
Amyloid fiber formation R-HSA-977225 0.959825 0.018 0 0
Parasitic Infection Pathways R-HSA-9824443 0.960100 0.018 0 0
Leishmania infection R-HSA-9658195 0.960100 0.018 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 0.962701 0.017 0 0
Peroxisomal lipid metabolism R-HSA-390918 0.963962 0.016 0 0
Reproduction R-HSA-1474165 0.967968 0.014 0 0
Cardiac conduction R-HSA-5576891 0.968931 0.014 0 0
Leishmania parasite growth and survival R-HSA-9664433 0.969111 0.014 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 0.969111 0.014 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 0.969946 0.013 0 0
Neurotransmitter release cycle R-HSA-112310 0.972035 0.012 0 0
Base Excision Repair R-HSA-73884 0.972035 0.012 0 0
Disease R-HSA-1643685 0.972147 0.012 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 0.975809 0.011 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 0.979075 0.009 0 0
GPCR downstream signalling R-HSA-388396 0.979335 0.009 0 0
DNA Repair R-HSA-73894 0.983725 0.007 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 0.983766 0.007 0 0
Metabolism of steroids R-HSA-8957322 0.984894 0.007 0 0
Platelet homeostasis R-HSA-418346 0.985959 0.006 0 0
G alpha (i) signalling events R-HSA-418594 0.986777 0.006 0 0
Keratinization R-HSA-6805567 0.988087 0.005 0 0
Selenoamino acid metabolism R-HSA-2408522 0.989543 0.005 0 0
Signaling by GPCR R-HSA-372790 0.990584 0.004 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 0.992676 0.003 0 0
Respiratory electron transport R-HSA-611105 0.993508 0.003 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 0.995858 0.002 0 0
Mitochondrial translation R-HSA-5368287 0.996338 0.002 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 0.996595 0.001 0 0
Parasite infection R-HSA-9664407 0.996595 0.001 0 0
Leishmania phagocytosis R-HSA-9664417 0.996595 0.001 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 0.996717 0.001 0 0
Visual phototransduction R-HSA-2187338 0.997455 0.001 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 0.997718 0.001 0 0
GPCR ligand binding R-HSA-500792 0.998689 0.001 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 0.998771 0.001 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 0.998838 0.001 0 0
Metabolism of nucleotides R-HSA-15869 0.999047 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 0.999264 0.000 0 0
Diseases of glycosylation R-HSA-3781865 0.999363 0.000 0 0
Transport of small molecules R-HSA-382551 0.999501 0.000 0 0
Sphingolipid metabolism R-HSA-428157 0.999657 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 0.999781 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 0.999800 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 0.999980 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 0.999987 0.000 0 0
Fatty acid metabolism R-HSA-8978868 0.999997 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 0.999999 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000 0.000 0 0
Biological oxidations R-HSA-211859 1.000000 0.000 0 0
Metabolism R-HSA-1430728 1.000000 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
HSF1-dependent transactivation R-HSA-3371571 9.281464e-14 13.032 0 0
Attenuation phase R-HSA-3371568 1.565414e-13 12.805 0 0
Cellular response to heat stress R-HSA-3371556 3.278600e-12 11.484 0 0
HSF1 activation R-HSA-3371511 4.278200e-11 10.369 0 0
Cell Cycle R-HSA-1640170 4.832446e-11 10.316 0 0
Cell Cycle, Mitotic R-HSA-69278 3.976410e-10 9.401 0 0
M Phase R-HSA-68886 1.103882e-09 8.957 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.140689e-09 8.669 0 0
Cellular responses to stress R-HSA-2262752 3.346874e-08 7.475 0 0
Mitotic Prometaphase R-HSA-68877 5.993898e-08 7.222 0 0
Cellular responses to stimuli R-HSA-8953897 5.925040e-08 7.227 0 0
Mitotic Anaphase R-HSA-68882 5.011637e-07 6.300 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.438646e-07 6.265 0 0
Aggrephagy R-HSA-9646399 6.197063e-07 6.208 0 0
Metabolism of RNA R-HSA-8953854 6.420410e-07 6.192 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 3.303171e-06 5.481 0 0
Separation of Sister Chromatids R-HSA-2467813 6.179757e-06 5.209 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.173531e-05 4.931 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 1.073186e-05 4.969 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.192129e-05 4.924 0 0
Selective autophagy R-HSA-9663891 1.173531e-05 4.931 0 0
PKR-mediated signaling R-HSA-9833482 1.673482e-05 4.776 0 0
Cell Cycle Checkpoints R-HSA-69620 2.809700e-05 4.551 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.762629e-05 4.559 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.259562e-05 4.487 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 3.767776e-05 4.424 0 0
Integration of provirus R-HSA-162592 3.648922e-05 4.438 0 0
Chaperone Mediated Autophagy R-HSA-9613829 4.618608e-05 4.335 0 0
mRNA Splicing - Major Pathway R-HSA-72163 6.368805e-05 4.196 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 7.233782e-05 4.141 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 6.952701e-05 4.158 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 8.039380e-05 4.095 0 0
Early Phase of HIV Life Cycle R-HSA-162594 9.841732e-05 4.007 0 0
Autophagy R-HSA-9612973 9.783156e-05 4.010 0 0
G2/M Transition R-HSA-69275 1.036707e-04 3.984 0 0
Mitotic G2-G2/M phases R-HSA-453274 1.182266e-04 3.927 0 0
mRNA Splicing R-HSA-72172 1.293293e-04 3.888 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 1.961347e-04 3.707 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 2.340733e-04 3.631 0 0
Macroautophagy R-HSA-1632852 2.641161e-04 3.578 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 2.877621e-04 3.541 0 0
Nuclear Envelope Breakdown R-HSA-2980766 3.397414e-04 3.469 0 0
Transport of connexons to the plasma membrane R-HSA-190872 3.634648e-04 3.440 0 0
Apoptotic execution phase R-HSA-75153 3.769805e-04 3.424 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.458155e-04 3.351 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.758819e-04 3.240 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 5.610026e-04 3.251 0 0
G2/M Checkpoints R-HSA-69481 7.130272e-04 3.147 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 8.024931e-04 3.096 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 8.957310e-04 3.048 0 0
Protein folding R-HSA-391251 9.652415e-04 3.015 0 0
Neutrophil degranulation R-HSA-6798695 9.778289e-04 3.010 0 0
Activation of ATR in response to replication stress R-HSA-176187 1.084643e-03 2.965 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.061740e-03 2.974 0 0
Mitotic Prophase R-HSA-68875 1.171699e-03 2.931 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.647629e-03 2.783 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.760395e-03 2.754 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.941582e-03 2.712 0 0
2-LTR circle formation R-HSA-164843 1.946496e-03 2.711 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 2.133952e-03 2.671 0 0
Cilium Assembly R-HSA-5617833 2.167909e-03 2.664 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.462701e-03 2.609 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 2.466874e-03 2.608 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 2.466874e-03 2.608 0 0
Regulation of TP53 Activity R-HSA-5633007 2.470520e-03 2.607 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 2.695684e-03 2.569 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.062862e-03 2.514 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.230748e-03 2.491 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.243049e-03 2.489 0 0
Interferon Signaling R-HSA-913531 3.752960e-03 2.426 0 0
DNA Replication Pre-Initiation R-HSA-69002 3.852788e-03 2.414 0 0
Host Interactions of HIV factors R-HSA-162909 4.120927e-03 2.385 0 0
DNA Double-Strand Break Repair R-HSA-5693532 4.135807e-03 2.383 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 4.302124e-03 2.366 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 4.830309e-03 2.316 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.979385e-03 2.303 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.979385e-03 2.303 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 5.100561e-03 2.292 0 0
HIV Infection R-HSA-162906 5.512292e-03 2.259 0 0
Gap junction trafficking R-HSA-190828 5.260720e-03 2.279 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.347977e-03 2.272 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.801759e-03 2.236 0 0
Autointegration results in viral DNA circles R-HSA-177539 5.801759e-03 2.236 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.738085e-03 2.241 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.946289e-03 2.226 0 0
Post NMDA receptor activation events R-HSA-438064 5.737580e-03 2.241 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 5.801759e-03 2.236 0 0
Gap junction assembly R-HSA-190861 6.449735e-03 2.190 0 0
Kinesins R-HSA-983189 6.472628e-03 2.189 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 6.477821e-03 2.189 0 0
Centrosome maturation R-HSA-380287 6.675929e-03 2.175 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.040415e-03 2.152 0 0
L1CAM interactions R-HSA-373760 6.658496e-03 2.177 0 0
Recycling pathway of L1 R-HSA-437239 7.050700e-03 2.152 0 0
Protein methylation R-HSA-8876725 7.379923e-03 2.132 0 0
Axon guidance R-HSA-422475 7.477408e-03 2.126 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.630346e-03 2.117 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.040968e-03 2.095 0 0
Synthesis of DNA R-HSA-69239 9.055743e-03 2.043 0 0
Gap junction trafficking and regulation R-HSA-157858 8.471975e-03 2.072 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.120568e-03 2.040 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 9.650215e-03 2.015 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 9.650215e-03 2.015 0 0
DNA Replication R-HSA-69306 9.653487e-03 2.015 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 1.035756e-02 1.985 0 0
HIV Life Cycle R-HSA-162587 1.159781e-02 1.936 0 0
Late endosomal microautophagy R-HSA-9615710 1.370889e-02 1.863 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.370889e-02 1.863 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.399607e-02 1.854 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.448637e-02 1.839 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.484607e-02 1.828 0 0
Cellular Senescence R-HSA-2559583 1.498825e-02 1.824 0 0
Activation of the pre-replicative complex R-HSA-68962 1.529095e-02 1.816 0 0
Switching of origins to a post-replicative state R-HSA-69052 1.696023e-02 1.771 0 0
S Phase R-HSA-69242 1.710777e-02 1.767 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.557170e-02 1.808 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 1.636605e-02 1.786 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 1.724335e-02 1.763 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 1.724335e-02 1.763 0 0
Nervous system development R-HSA-9675108 1.784692e-02 1.748 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.877690e-02 1.726 0 0
PECAM1 interactions R-HSA-210990 1.889626e-02 1.724 0 0
DNA Repair R-HSA-73894 1.925113e-02 1.716 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 2.025936e-02 1.693 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 2.258282e-02 1.646 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.207570e-02 1.656 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.207570e-02 1.656 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.207570e-02 1.656 0 0
Signaling by RAS mutants R-HSA-6802949 2.207570e-02 1.656 0 0
Interleukin-12 signaling R-HSA-9020591 2.052553e-02 1.688 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 2.352198e-02 1.629 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 2.356945e-02 1.628 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 2.386287e-02 1.622 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.574441e-02 1.589 0 0
Intraflagellar transport R-HSA-5620924 2.574441e-02 1.589 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.578949e-02 1.589 0 0
HCMV Early Events R-HSA-9609690 2.729876e-02 1.564 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.242315e-02 1.489 0 0
Frs2-mediated activation R-HSA-170968 3.104268e-02 1.508 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 3.257076e-02 1.487 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.915437e-02 1.535 0 0
RET signaling R-HSA-8853659 2.982233e-02 1.525 0 0
Apoptosis R-HSA-109581 3.016639e-02 1.520 0 0
Neurodegenerative Diseases R-HSA-8863678 3.280323e-02 1.484 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.280323e-02 1.484 0 0
Organelle biogenesis and maintenance R-HSA-1852241 3.334628e-02 1.477 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 3.424189e-02 1.465 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.424805e-02 1.465 0 0
Orc1 removal from chromatin R-HSA-68949 3.424805e-02 1.465 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.435528e-02 1.464 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.435528e-02 1.464 0 0
Hedgehog 'off' state R-HSA-5610787 3.547192e-02 1.450 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 4.085461e-02 1.389 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 3.662572e-02 1.436 0 0
Myogenesis R-HSA-525793 3.997876e-02 1.398 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 4.085461e-02 1.389 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 3.814885e-02 1.419 0 0
Homology Directed Repair R-HSA-5693538 4.063307e-02 1.391 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.997876e-02 1.398 0 0
Interleukin-12 family signaling R-HSA-447115 4.010301e-02 1.397 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 4.169185e-02 1.380 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 4.267223e-02 1.370 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 4.387493e-02 1.358 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 4.438231e-02 1.353 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 4.640583e-02 1.333 0 0
Prolonged ERK activation events R-HSA-169893 4.640583e-02 1.333 0 0
Nucleotide Excision Repair R-HSA-5696398 4.661473e-02 1.331 0 0
MAP2K and MAPK activation R-HSA-5674135 4.751087e-02 1.323 0 0
G2/M DNA damage checkpoint R-HSA-69473 4.752896e-02 1.323 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 4.797658e-02 1.319 0 0
Signaling by Hedgehog R-HSA-5358351 4.831692e-02 1.316 0 0
Protein ubiquitination R-HSA-8852135 5.008409e-02 1.300 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.221799e-02 1.282 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.221799e-02 1.282 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.221799e-02 1.282 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 5.228301e-02 1.282 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 6.065143e-02 1.217 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 6.150509e-02 1.211 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.277140e-02 1.202 0 0
CHL1 interactions R-HSA-447041 6.065143e-02 1.217 0 0
Uptake and function of anthrax toxins R-HSA-5210891 5.836310e-02 1.234 0 0
Cytokine Signaling in Immune system R-HSA-1280215 6.066210e-02 1.217 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.483215e-02 1.188 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 6.483215e-02 1.188 0 0
Polo-like kinase mediated events R-HSA-156711 6.483215e-02 1.188 0 0
Diseases of Telomere Maintenance R-HSA-9673013 7.630100e-02 1.117 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 7.630100e-02 1.117 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 7.630100e-02 1.117 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 7.630100e-02 1.117 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 7.630100e-02 1.117 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 7.630100e-02 1.117 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.683078e-02 1.114 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 6.613688e-02 1.180 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 7.028701e-02 1.153 0 0
Diseases of mitotic cell cycle R-HSA-9675126 6.641708e-02 1.178 0 0
Nuclear RNA decay R-HSA-9930044 7.152658e-02 1.146 0 0
DNA strand elongation R-HSA-69190 6.641708e-02 1.178 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 7.152658e-02 1.146 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 7.335668e-02 1.135 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 7.532817e-02 1.123 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 7.630100e-02 1.117 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.709616e-02 1.113 0 0
Negative regulation of MET activity R-HSA-6807004 7.870215e-02 1.104 0 0
Processing of DNA double-strand break ends R-HSA-5693607 6.722070e-02 1.172 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 6.621407e-02 1.179 0 0
Cellular response to hypoxia R-HSA-1234174 7.342374e-02 1.134 0 0
HCMV Infection R-HSA-9609646 7.641264e-02 1.117 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.732079e-02 1.172 0 0
Glycolysis R-HSA-70171 7.824587e-02 1.107 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 6.627776e-02 1.179 0 0
Signal transduction by L1 R-HSA-445144 7.870215e-02 1.104 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 6.649670e-02 1.177 0 0
Programmed Cell Death R-HSA-5357801 6.890913e-02 1.162 0 0
Protein-protein interactions at synapses R-HSA-6794362 8.038263e-02 1.095 0 0
Defective SLC34A2 causes PALM R-HSA-5687583 1.122430e-01 0.950 0 0
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) R-HSA-5619045 1.122430e-01 0.950 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.122430e-01 0.950 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.122430e-01 0.950 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.467886e-01 0.833 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.467886e-01 0.833 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.467886e-01 0.833 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.467886e-01 0.833 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.467886e-01 0.833 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.467886e-01 0.833 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.467886e-01 0.833 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.467886e-01 0.833 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.467886e-01 0.833 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.467886e-01 0.833 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.467886e-01 0.833 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.467886e-01 0.833 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.799919e-01 0.745 0 0
Lipophagy R-HSA-9613354 8.301190e-02 1.081 0 0
ALK mutants bind TKIs R-HSA-9700645 8.301190e-02 1.081 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.119050e-01 0.674 0 0
Signaling by MAP2K mutants R-HSA-9652169 2.119050e-01 0.674 0 0
Reelin signalling pathway R-HSA-8866376 2.425780e-01 0.615 0 0
Defective binding of VWF variant to GPIb:IX:V R-HSA-9846298 2.425780e-01 0.615 0 0
Defective F9 activation R-HSA-9673221 2.425780e-01 0.615 0 0
Enhanced binding of GP1BA variant to VWF multimer:collagen R-HSA-9845620 2.425780e-01 0.615 0 0
Plus-strand DNA synthesis R-HSA-164525 2.720590e-01 0.565 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.720590e-01 0.565 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 2.720590e-01 0.565 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.720590e-01 0.565 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.608153e-02 1.065 0 0
Signaling by LTK in cancer R-HSA-9842640 3.003942e-01 0.522 0 0
STAT5 Activation R-HSA-9645135 3.003942e-01 0.522 0 0
Uncoating of the HIV Virion R-HSA-162585 3.003942e-01 0.522 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 3.003942e-01 0.522 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 3.003942e-01 0.522 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 3.003942e-01 0.522 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 3.003942e-01 0.522 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 3.003942e-01 0.522 0 0
Spry regulation of FGF signaling R-HSA-1295596 1.747104e-01 0.758 0 0
Processive synthesis on the lagging strand R-HSA-69183 1.747104e-01 0.758 0 0
G beta:gamma signalling through BTK R-HSA-8964315 1.747104e-01 0.758 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.888778e-01 0.724 0 0
Phosphorylation of the APC/C R-HSA-176412 1.888778e-01 0.724 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.888778e-01 0.724 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 3.276281e-01 0.485 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 3.276281e-01 0.485 0 0
Disinhibition of SNARE formation R-HSA-114516 3.276281e-01 0.485 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 3.276281e-01 0.485 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 3.276281e-01 0.485 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.801021e-02 1.055 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 2.031934e-01 0.692 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 1.449185e-01 0.839 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 2.176244e-01 0.662 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 2.176244e-01 0.662 0 0
Reverse Transcription of HIV RNA R-HSA-162589 3.538035e-01 0.451 0 0
Minus-strand DNA synthesis R-HSA-164516 3.538035e-01 0.451 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.538035e-01 0.451 0 0
Formation of annular gap junctions R-HSA-196025 3.538035e-01 0.451 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.538035e-01 0.451 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 1.541987e-01 0.812 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.125448e-01 0.949 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 2.321402e-01 0.634 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 1.636593e-01 0.786 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 1.191060e-01 0.924 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.311697e-02 1.031 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 1.258284e-01 0.900 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 1.732875e-01 0.761 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.467124e-01 0.608 0 0
Gap junction degradation R-HSA-190873 3.789614e-01 0.421 0 0
MAPK1 (ERK2) activation R-HSA-112411 3.789614e-01 0.421 0 0
Meiotic synapsis R-HSA-1221632 9.808899e-02 1.008 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 9.808899e-02 1.008 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 1.830708e-01 0.737 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 1.830708e-01 0.737 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 1.397362e-01 0.855 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.137840e-01 0.944 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.030531e-01 0.692 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.030531e-01 0.692 0 0
Binding and entry of HIV virion R-HSA-173107 4.031413e-01 0.395 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.031413e-01 0.395 0 0
Folding of actin by CCT/TriC R-HSA-390450 4.031413e-01 0.395 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 1.616724e-01 0.791 0 0
Nucleosome assembly R-HSA-774815 1.616724e-01 0.791 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 2.132276e-01 0.671 0 0
Striated Muscle Contraction R-HSA-390522 2.132276e-01 0.671 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 2.132276e-01 0.671 0 0
Metabolism of non-coding RNA R-HSA-194441 1.305990e-01 0.884 0 0
snRNP Assembly R-HSA-191859 1.305990e-01 0.884 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 1.692483e-01 0.771 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 2.905137e-01 0.537 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.905137e-01 0.537 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 2.235087e-01 0.651 0 0
Notch-HLH transcription pathway R-HSA-350054 3.050673e-01 0.516 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.050673e-01 0.516 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.514177e-01 0.820 0 0
mRNA 3'-end processing R-HSA-72187 2.170584e-01 0.663 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 3.483188e-01 0.458 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 3.483188e-01 0.458 0 0
G protein gated Potassium channels R-HSA-1296059 3.483188e-01 0.458 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.868022e-01 0.542 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 2.215741e-01 0.654 0 0
Packaging Of Telomere Ends R-HSA-171306 3.766538e-01 0.424 0 0
Post-translational protein phosphorylation R-HSA-8957275 2.671750e-01 0.573 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 2.030531e-01 0.692 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.759225e-01 0.559 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 2.235087e-01 0.651 0 0
Eukaryotic Translation Elongation R-HSA-156842 2.218681e-01 0.654 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 1.511151e-01 0.821 0 0
Integrin signaling R-HSA-354192 2.030531e-01 0.692 0 0
Chromosome Maintenance R-HSA-73886 9.302652e-02 1.031 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.652811e-01 0.576 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 1.364850e-01 0.865 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 3.830312e-01 0.417 0 0
Telomere Maintenance R-HSA-157579 2.605569e-01 0.584 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 1.325769e-01 0.878 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.092889e-01 0.679 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.747104e-01 0.758 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 2.031934e-01 0.692 0 0
G-protein activation R-HSA-202040 2.759225e-01 0.559 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 3.082606e-01 0.511 0 0
Extension of Telomeres R-HSA-180786 2.766672e-01 0.558 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 1.616724e-01 0.791 0 0
Regulation of Apoptosis R-HSA-169911 8.801021e-02 1.055 0 0
Telomere Extension By Telomerase R-HSA-171319 3.906309e-01 0.408 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 1.616724e-01 0.791 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.761894e-02 1.010 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.761894e-02 1.010 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.158266e-01 0.936 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 2.759225e-01 0.559 0 0
Thromboxane signalling through TP receptor R-HSA-428930 3.339867e-01 0.476 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.761155e-01 0.559 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 3.766538e-01 0.424 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.305990e-01 0.884 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.258284e-01 0.900 0 0
ESR-mediated signaling R-HSA-8939211 1.486743e-01 0.828 0 0
Lagging Strand Synthesis R-HSA-69186 2.759225e-01 0.559 0 0
Nuclear import of Rev protein R-HSA-180746 8.232649e-02 1.084 0 0
Long-term potentiation R-HSA-9620244 3.483188e-01 0.458 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.944499e-01 0.711 1 1
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 3.625456e-01 0.441 0 0
Formation of the posterior neural plate R-HSA-9832991 1.074308e-01 0.969 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.425780e-01 0.615 0 0
IRF3 mediated activation of type 1 IFN R-HSA-1606341 2.425780e-01 0.615 0 0
PTK6 Down-Regulation R-HSA-8849472 2.425780e-01 0.615 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.176244e-01 0.662 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.538035e-01 0.451 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.258284e-01 0.900 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 1.258284e-01 0.900 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 1.732875e-01 0.761 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.789614e-01 0.421 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 4.031413e-01 0.395 0 0
RAF activation R-HSA-5673000 2.235087e-01 0.651 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.483188e-01 0.458 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 3.625456e-01 0.441 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 3.190137e-01 0.496 0 0
Signaling by FGFR4 R-HSA-5654743 3.297710e-01 0.482 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.327070e-01 0.877 0 0
Proteasome assembly R-HSA-9907900 1.542246e-01 0.812 0 0
Signaling by FGFR3 R-HSA-5654741 3.512644e-01 0.454 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 1.732875e-01 0.761 0 0
Meiosis R-HSA-1500620 3.107600e-01 0.508 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.625456e-01 0.441 0 0
DNA Double Strand Break Response R-HSA-5693606 1.803467e-01 0.744 0 0
Inhibition of nitric oxide production R-HSA-9636249 1.799919e-01 0.745 0 0
Activation of C3 and C5 R-HSA-174577 2.425780e-01 0.615 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.747104e-01 0.758 0 0
Prostacyclin signalling through prostacyclin receptor R-HSA-392851 2.467124e-01 0.608 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.007131e-01 0.697 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 2.287104e-01 0.641 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 9.808899e-02 1.008 1 1
Hh mutants abrogate ligand secretion R-HSA-5387390 1.469106e-01 0.833 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.789614e-01 0.421 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 2.321402e-01 0.634 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 2.030531e-01 0.692 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.352363e-01 0.475 0 0
FGFR1 mutant receptor activation R-HSA-1839124 2.030531e-01 0.692 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.122430e-01 0.950 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.122430e-01 0.950 0 0
Manipulation of host energy metabolism R-HSA-9636667 1.122430e-01 0.950 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.467886e-01 0.833 0 0
C6 deamination of adenosine R-HSA-75102 1.467886e-01 0.833 0 0
STAT6-mediated induction of chemokines R-HSA-3249367 1.799919e-01 0.745 0 0
Type II Na+/Pi cotransporters R-HSA-427589 1.799919e-01 0.745 0 0
Unwinding of DNA R-HSA-176974 8.301190e-02 1.081 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 2.119050e-01 0.674 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.202715e-01 0.920 0 0
Regulation of IFNG signaling R-HSA-877312 1.334650e-01 0.875 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 2.720590e-01 0.565 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.469646e-01 0.833 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 3.003942e-01 0.522 0 0
G2/M DNA replication checkpoint R-HSA-69478 3.003942e-01 0.522 0 0
FASTK family proteins regulate processing and stability of mitochondrial RNAs R-HSA-9837092 1.747104e-01 0.758 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 3.276281e-01 0.485 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 3.538035e-01 0.451 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 2.321402e-01 0.634 0 0
Presynaptic function of Kainate receptors R-HSA-500657 2.321402e-01 0.634 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 3.789614e-01 0.421 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.031922e-01 0.986 0 0
DNA replication initiation R-HSA-68952 4.031413e-01 0.395 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 4.031413e-01 0.395 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 1.616724e-01 0.791 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 2.905137e-01 0.537 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 3.195641e-01 0.495 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 2.088397e-01 0.680 0 0
Complex III assembly R-HSA-9865881 3.339867e-01 0.476 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 3.339867e-01 0.476 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 3.339867e-01 0.476 0 0
Deadenylation of mRNA R-HSA-429947 3.339867e-01 0.476 0 0
Regulation of CDH1 Function R-HSA-9764561 2.593241e-01 0.586 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.941910e-01 0.531 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.512644e-01 0.454 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 3.385051e-01 0.470 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 3.960248e-01 0.402 0 0
Signaling by VEGF R-HSA-194138 1.094823e-01 0.961 0 0
Platelet activation, signaling and aggregation R-HSA-76002 1.304297e-01 0.885 0 0
Signaling by ALK in cancer R-HSA-9700206 3.352363e-01 0.475 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.358314e-01 0.867 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 3.483188e-01 0.458 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 1.612075e-01 0.793 0 0
UCH proteinases R-HSA-5689603 2.431774e-01 0.614 0 0
rRNA processing R-HSA-72312 1.337983e-01 0.874 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 1.191060e-01 0.924 0 0
Signalling to ERKs R-HSA-187687 2.338846e-01 0.631 0 0
MAPK family signaling cascades R-HSA-5683057 2.930919e-01 0.533 0 0
Neurofascin interactions R-HSA-447043 3.003942e-01 0.522 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.538035e-01 0.451 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.339867e-01 0.476 0 0
TBC/RABGAPs R-HSA-8854214 3.297710e-01 0.482 0 0
Late Phase of HIV Life Cycle R-HSA-162599 3.048496e-01 0.516 0 0
Neurexins and neuroligins R-HSA-6794361 9.311697e-02 1.031 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.145075e-01 0.669 1 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.258284e-01 0.900 0 0
Defects of platelet adhesion to exposed collagen R-HSA-9823587 2.720590e-01 0.565 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.276281e-01 0.485 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 2.176244e-01 0.662 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.030531e-01 0.692 0 0
Regulation of CDH11 function R-HSA-9762292 4.031413e-01 0.395 0 0
Formation of intermediate mesoderm R-HSA-9761174 4.031413e-01 0.395 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 1.616724e-01 0.791 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 2.132276e-01 0.671 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 1.692483e-01 0.771 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 3.050673e-01 0.516 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 3.919100e-01 0.407 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.619847e-01 0.441 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 9.311697e-02 1.031 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 2.467124e-01 0.608 0 0
Platelet degranulation R-HSA-114608 1.164928e-01 0.934 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.741376e-01 0.427 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 2.467124e-01 0.608 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.122430e-01 0.950 0 0
Diseases of cellular response to stress R-HSA-9675132 1.467886e-01 0.833 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.467886e-01 0.833 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 1.334650e-01 0.875 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 2.720590e-01 0.565 0 0
VLDL clearance R-HSA-8964046 3.276281e-01 0.485 0 0
Type I hemidesmosome assembly R-HSA-446107 3.538035e-01 0.451 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.538035e-01 0.451 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.125448e-01 0.949 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 2.467124e-01 0.608 0 0
mRNA Editing R-HSA-75072 3.789614e-01 0.421 0 0
ARMS-mediated activation R-HSA-170984 3.789614e-01 0.421 0 0
Calcineurin activates NFAT R-HSA-2025928 3.789614e-01 0.421 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 1.929968e-01 0.714 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 2.759225e-01 0.559 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.031413e-01 0.395 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 2.338846e-01 0.631 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 2.338846e-01 0.631 0 0
Degradation of CRY and PER proteins R-HSA-9932298 3.082606e-01 0.511 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.082606e-01 0.511 0 0
Opioid Signalling R-HSA-111885 1.764869e-01 0.753 0 0
Aquaporin-mediated transport R-HSA-445717 2.941910e-01 0.531 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.467124e-01 0.608 0 0
Membrane Trafficking R-HSA-199991 1.625125e-01 0.789 1 0
Vesicle-mediated transport R-HSA-5653656 3.776975e-01 0.423 1 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.679702e-01 0.572 0 0
Calmodulin induced events R-HSA-111933 9.387814e-02 1.027 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.538035e-01 0.451 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 3.789614e-01 0.421 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.381664e-01 0.860 0 0
Synthesis of PC R-HSA-1483191 3.726772e-01 0.429 0 0
CaM pathway R-HSA-111997 9.387814e-02 1.027 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.727858e-01 0.564 0 0
Malate-aspartate shuttle R-HSA-9856872 1.607267e-01 0.794 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 1.125448e-01 0.949 0 0
Degradation of DVL R-HSA-4641258 2.548763e-01 0.594 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 1.870106e-01 0.728 0 0
tRNA processing in the nucleus R-HSA-6784531 3.030069e-01 0.519 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 3.485971e-01 0.458 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 3.184475e-01 0.497 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 2.940399e-01 0.532 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 2.761155e-01 0.559 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 2.754169e-01 0.560 0 0
Gene expression (Transcription) R-HSA-74160 2.144374e-01 0.669 0 0
Transmission across Chemical Synapses R-HSA-112315 2.092889e-01 0.679 0 0
Syndecan interactions R-HSA-3000170 1.098576e-01 0.959 0 0
Hedgehog ligand biogenesis R-HSA-5358346 2.088397e-01 0.680 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.468961e-01 0.833 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.468961e-01 0.833 0 0
Ca-dependent events R-HSA-111996 1.397362e-01 0.855 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 2.030531e-01 0.692 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 2.390401e-01 0.622 0 0
NrCAM interactions R-HSA-447038 2.425780e-01 0.615 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 1.202715e-01 0.920 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 2.720590e-01 0.565 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 3.003942e-01 0.522 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.747104e-01 0.758 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 1.888778e-01 0.724 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.276281e-01 0.485 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 3.276281e-01 0.485 0 0
Regulation of PTEN localization R-HSA-8948747 3.276281e-01 0.485 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 3.276281e-01 0.485 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 8.232649e-02 1.084 0 0
Passive transport by Aquaporins R-HSA-432047 2.031934e-01 0.692 0 0
Defective factor IX causes hemophilia B R-HSA-9668250 4.031413e-01 0.395 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 4.031413e-01 0.395 0 0
DAG and IP3 signaling R-HSA-1489509 1.616724e-01 0.791 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.158266e-01 0.936 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 2.443442e-01 0.612 0 0
Degradation of AXIN R-HSA-4641257 2.548763e-01 0.594 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 2.548763e-01 0.594 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.665974e-01 0.778 0 0
Neuronal System R-HSA-112316 1.711641e-01 0.767 0 0
Adherens junctions interactions R-HSA-418990 2.408684e-01 0.618 0 0
Cell-cell junction organization R-HSA-421270 2.835562e-01 0.547 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 3.649316e-01 0.438 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 1.449185e-01 0.839 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 3.625456e-01 0.441 0 0
Cell junction organization R-HSA-446728 2.990099e-01 0.524 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.830708e-01 0.737 0 0
Sensory processing of sound R-HSA-9659379 2.653086e-01 0.576 0 0
Glucose metabolism R-HSA-70326 1.540634e-01 0.812 0 0
Gene Silencing by RNA R-HSA-211000 3.352363e-01 0.475 0 0
Base Excision Repair R-HSA-73884 2.032923e-01 0.692 0 0
Maturation of nucleoprotein R-HSA-9683610 1.469646e-01 0.833 0 0
Activation of SMO R-HSA-5635838 1.888778e-01 0.724 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.176244e-01 0.662 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.389526e-01 0.857 0 0
Influenza Infection R-HSA-168255 3.873812e-01 0.412 0 0
Semaphorin interactions R-HSA-373755 1.546372e-01 0.811 0 0
PLC beta mediated events R-HSA-112043 2.941910e-01 0.531 0 0
Response of endothelial cells to shear stress R-HSA-9860931 9.115828e-02 1.040 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 3.789614e-01 0.421 0 0
Cell-Cell communication R-HSA-1500931 3.585268e-01 0.445 0 0
DNA Damage Bypass R-HSA-73893 3.939508e-01 0.405 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.425780e-01 0.615 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 1.202715e-01 0.920 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.720590e-01 0.565 0 0
Nef and signal transduction R-HSA-164944 3.003942e-01 0.522 0 0
Formation of the anterior neural plate R-HSA-9823739 1.747104e-01 0.758 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 3.276281e-01 0.485 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.176244e-01 0.662 0 0
Interleukin-1 processing R-HSA-448706 3.789614e-01 0.421 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.789614e-01 0.421 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.789614e-01 0.421 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 3.789614e-01 0.421 0 0
Basigin interactions R-HSA-210991 2.759225e-01 0.559 0 0
Vpu mediated degradation of CD4 R-HSA-180534 2.132276e-01 0.671 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 2.235087e-01 0.651 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 2.235087e-01 0.651 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.050673e-01 0.516 0 0
Degradation of CDH1 R-HSA-9766229 1.926846e-01 0.715 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 2.654702e-01 0.576 0 0
Mitochondrial RNA degradation R-HSA-9836573 3.339867e-01 0.476 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.082606e-01 0.511 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.082606e-01 0.511 0 0
Signaling by ROBO receptors R-HSA-376176 2.707041e-01 0.568 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 1.325434e-01 0.878 0 0
Developmental Biology R-HSA-1266738 2.935761e-01 0.532 0 0
NGF-stimulated transcription R-HSA-9031628 3.833348e-01 0.416 0 0
Viral Infection Pathways R-HSA-9824446 1.792868e-01 0.746 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 1.929968e-01 0.714 0 0
PERK regulates gene expression R-HSA-381042 8.801021e-02 1.055 0 0
PKMTs methylate histone lysines R-HSA-3214841 2.975204e-01 0.526 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.256273e-01 0.901 0 0
Gluconeogenesis R-HSA-70263 3.833348e-01 0.416 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.941910e-01 0.531 0 0
G-protein mediated events R-HSA-112040 3.474128e-01 0.459 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 1.747104e-01 0.758 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 1.888778e-01 0.724 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.031934e-01 0.692 0 0
Disorders of Developmental Biology R-HSA-9675151 2.031934e-01 0.692 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.789614e-01 0.421 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.613146e-01 0.583 0 0
Josephin domain DUBs R-HSA-5689877 4.031413e-01 0.395 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 2.868022e-01 0.542 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 2.975204e-01 0.526 0 0
Response of Mtb to phagocytosis R-HSA-9637690 3.297710e-01 0.482 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 3.906309e-01 0.408 0 0
G1/S Transition R-HSA-69206 1.966234e-01 0.706 0 0
Diseases of programmed cell death R-HSA-9645723 3.416326e-01 0.466 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 1.737741e-01 0.760 0 0
tRNA processing R-HSA-72306 2.225644e-01 0.653 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.507345e-01 0.601 0 0
Intracellular signaling by second messengers R-HSA-9006925 2.747478e-01 0.561 0 0
Sema4D in semaphorin signaling R-HSA-400685 3.483188e-01 0.458 0 0
Signaling by NOTCH4 R-HSA-9013694 1.111236e-01 0.954 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 1.202715e-01 0.920 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 8.801021e-02 1.055 0 0
Interleukin-37 signaling R-HSA-9008059 1.732875e-01 0.761 0 0
Maturation of nucleoprotein R-HSA-9694631 2.467124e-01 0.608 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.789614e-01 0.421 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.050673e-01 0.516 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.654702e-01 0.576 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 2.761155e-01 0.559 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 2.975204e-01 0.526 0 0
TRP channels R-HSA-3295583 3.625456e-01 0.441 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 3.405240e-01 0.468 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.512644e-01 0.454 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.729044e-01 0.564 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 2.605569e-01 0.584 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 2.457793e-01 0.609 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 3.297710e-01 0.482 0 0
Regulation of TP53 Degradation R-HSA-6804757 2.443442e-01 0.612 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 3.741376e-01 0.427 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.929968e-01 0.714 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.766538e-01 0.424 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 2.170584e-01 0.663 0 0
Mismatch Repair R-HSA-5358508 2.321402e-01 0.634 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 3.820710e-01 0.418 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.362458e-01 0.866 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.761155e-01 0.559 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 8.232649e-02 1.084 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.759225e-01 0.559 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.195641e-01 0.495 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.868022e-01 0.542 0 0
Hedgehog 'on' state R-HSA-5632684 2.075142e-01 0.683 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 8.539074e-02 1.069 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 2.216086e-01 0.654 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 3.625456e-01 0.441 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 3.919100e-01 0.407 0 0
Formation of paraxial mesoderm R-HSA-9793380 2.941910e-01 0.531 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 1.469646e-01 0.833 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 3.538035e-01 0.451 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 1.061499e-01 0.974 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.905137e-01 0.537 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 2.321402e-01 0.634 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 2.467124e-01 0.608 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.067379e-01 0.972 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.512644e-01 0.454 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.512644e-01 0.454 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.338846e-01 0.631 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 8.106400e-02 1.091 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 3.830312e-01 0.417 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 4.031413e-01 0.395 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.910177e-01 0.408 0 0
Stabilization of p53 R-HSA-69541 2.761155e-01 0.559 0 0
SARS-CoV-1 Infection R-HSA-9678108 3.651668e-01 0.438 0 0
Somitogenesis R-HSA-9824272 3.512644e-01 0.454 0 0
Unfolded Protein Response (UPR) R-HSA-381119 9.662269e-02 1.015 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.939508e-01 0.405 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.939508e-01 0.405 0 0
MHC class II antigen presentation R-HSA-2132295 9.942390e-02 1.003 0 0
Diseases of DNA repair R-HSA-9675135 1.692483e-01 0.771 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 4.037829e-01 0.394 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 4.044658e-01 0.393 0 0
Platelet calcium homeostasis R-HSA-418360 4.044658e-01 0.393 0 0
Termination of translesion DNA synthesis R-HSA-5656169 4.044658e-01 0.393 0 0
Glucagon-type ligand receptors R-HSA-420092 4.044658e-01 0.393 0 0
Interferon alpha/beta signaling R-HSA-909733 4.049905e-01 0.393 0 0
Signaling by FGFR in disease R-HSA-1226099 4.096071e-01 0.388 0 0
Deubiquitination R-HSA-5688426 4.102031e-01 0.387 0 0
Signaling by TGFB family members R-HSA-9006936 4.107838e-01 0.386 0 0
Formation of a pool of free 40S subunits R-HSA-72689 4.115290e-01 0.386 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.150321e-01 0.382 0 0
Ribosome-associated quality control R-HSA-9948299 4.180067e-01 0.379 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 4.181484e-01 0.379 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 4.181484e-01 0.379 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 4.181484e-01 0.379 0 0
Signaling by Interleukins R-HSA-449147 4.190249e-01 0.378 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 4.192605e-01 0.378 0 0
PTEN Regulation R-HSA-6807070 4.243970e-01 0.372 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 4.254854e-01 0.371 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 4.254854e-01 0.371 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 4.254854e-01 0.371 0 0
vRNP Assembly R-HSA-192905 4.263812e-01 0.370 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 4.263812e-01 0.370 0 0
Suppression of apoptosis R-HSA-9635465 4.263812e-01 0.370 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.263812e-01 0.370 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 4.269746e-01 0.370 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 4.271966e-01 0.369 0 0
Trafficking of AMPA receptors R-HSA-399719 4.316697e-01 0.365 0 0
Budding and maturation of HIV virion R-HSA-162588 4.316697e-01 0.365 0 0
Molecules associated with elastic fibres R-HSA-2129379 4.316697e-01 0.365 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.358730e-01 0.361 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.358730e-01 0.361 0 0
Smooth Muscle Contraction R-HSA-445355 4.358730e-01 0.361 0 0
Regulation of PTEN stability and activity R-HSA-8948751 4.358730e-01 0.361 0 0
RNA Polymerase I Transcription R-HSA-73864 4.446487e-01 0.352 0 0
ABC transporter disorders R-HSA-5619084 4.446487e-01 0.352 0 0
PCP/CE pathway R-HSA-4086400 4.446487e-01 0.352 0 0
Inwardly rectifying K+ channels R-HSA-1296065 4.450214e-01 0.352 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.450214e-01 0.352 0 0
G0 and Early G1 R-HSA-1538133 4.450214e-01 0.352 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 4.466985e-01 0.350 0 0
Developmental Cell Lineages R-HSA-9734767 4.484116e-01 0.348 0 0
DS-GAG biosynthesis R-HSA-2022923 4.487176e-01 0.348 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 4.487176e-01 0.348 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.487176e-01 0.348 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.487176e-01 0.348 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 4.487176e-01 0.348 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.487176e-01 0.348 0 0
Activation of RAC1 R-HSA-428540 4.487176e-01 0.348 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 4.487176e-01 0.348 0 0
Signaling by Nuclear Receptors R-HSA-9006931 4.524475e-01 0.344 0 0
G alpha (z) signalling events R-HSA-418597 4.564302e-01 0.341 0 0
Signaling by NOTCH3 R-HSA-9012852 4.564302e-01 0.341 0 0
Signaling by NOTCH R-HSA-157118 4.569164e-01 0.340 0 0
Selenocysteine synthesis R-HSA-2408557 4.576054e-01 0.340 0 0
G-protein beta:gamma signalling R-HSA-397795 4.581963e-01 0.339 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.581963e-01 0.339 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 4.581963e-01 0.339 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 4.581963e-01 0.339 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.581963e-01 0.339 0 0
Signaling by FGFR2 R-HSA-5654738 4.619355e-01 0.335 0 0
Regulation of endogenous retroelements R-HSA-9842860 4.651943e-01 0.332 0 0
Signaling by FGFR1 R-HSA-5654736 4.665903e-01 0.331 0 0
TNF signaling R-HSA-75893 4.665903e-01 0.331 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 4.665903e-01 0.331 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 4.701855e-01 0.328 0 0
VLDLR internalisation and degradation R-HSA-8866427 4.701855e-01 0.328 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.701855e-01 0.328 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 4.701855e-01 0.328 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.701855e-01 0.328 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 4.701855e-01 0.328 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.701855e-01 0.328 0 0
Proline catabolism R-HSA-70688 4.701855e-01 0.328 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 4.701855e-01 0.328 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 4.701855e-01 0.328 0 0
Leading Strand Synthesis R-HSA-69109 4.701855e-01 0.328 0 0
Maple Syrup Urine Disease R-HSA-9865114 4.701855e-01 0.328 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 4.701855e-01 0.328 0 0
Polymerase switching R-HSA-69091 4.701855e-01 0.328 0 0
Diseases associated with surfactant metabolism R-HSA-5687613 4.701855e-01 0.328 0 0
Interleukin-15 signaling R-HSA-8983432 4.701855e-01 0.328 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.701855e-01 0.328 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 4.701855e-01 0.328 0 0
RNA Polymerase II Transcription R-HSA-73857 4.705536e-01 0.327 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 4.711879e-01 0.327 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 4.790313e-01 0.320 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 4.802733e-01 0.319 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 4.809803e-01 0.318 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 4.809803e-01 0.318 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 4.809803e-01 0.318 0 0
PIP3 activates AKT signaling R-HSA-1257604 4.815653e-01 0.317 0 0
Signaling by NOTCH2 R-HSA-1980145 4.839906e-01 0.315 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 4.839906e-01 0.315 0 0
Dual Incision in GG-NER R-HSA-5696400 4.839906e-01 0.315 0 0
Signal amplification R-HSA-392518 4.839906e-01 0.315 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.839906e-01 0.315 0 0
RA biosynthesis pathway R-HSA-5365859 4.839906e-01 0.315 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.839906e-01 0.315 0 0
Dual incision in TC-NER R-HSA-6782135 4.866512e-01 0.313 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.875001e-01 0.312 0 0
Activation of HOX genes during differentiation R-HSA-5619507 4.877591e-01 0.312 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 4.877591e-01 0.312 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.908187e-01 0.309 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.908187e-01 0.309 0 0
Acyl chain remodeling of DAG and TAG R-HSA-1482883 4.908187e-01 0.309 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.908187e-01 0.309 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.908187e-01 0.309 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 4.908187e-01 0.309 0 0
Processing of SMDT1 R-HSA-8949664 4.908187e-01 0.309 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.908187e-01 0.309 0 0
rRNA modification in the mitochondrion R-HSA-6793080 4.908187e-01 0.309 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 4.908187e-01 0.309 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.908187e-01 0.309 0 0
Ub-specific processing proteases R-HSA-5689880 4.932511e-01 0.307 0 0
Gastrulation R-HSA-9758941 4.938655e-01 0.306 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 4.959125e-01 0.305 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.012421e-01 0.300 0 0
Platelet homeostasis R-HSA-418346 5.026127e-01 0.299 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.026127e-01 0.299 0 0
Co-inhibition by PD-1 R-HSA-389948 5.035504e-01 0.298 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 5.062475e-01 0.296 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 5.063405e-01 0.296 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.063405e-01 0.296 0 0
Signaling by ERBB2 R-HSA-1227986 5.063405e-01 0.296 0 0
Metabolism of polyamines R-HSA-351202 5.063405e-01 0.296 0 0
PRC2 methylates histones and DNA R-HSA-212300 5.090097e-01 0.293 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 5.090097e-01 0.293 0 0
FLT3 signaling in disease R-HSA-9682385 5.090097e-01 0.293 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.106495e-01 0.292 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 5.106495e-01 0.292 0 0
Removal of the Flap Intermediate R-HSA-69166 5.106495e-01 0.292 0 0
Signaling by FGFR4 in disease R-HSA-5655291 5.106495e-01 0.292 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5.106495e-01 0.292 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 5.106495e-01 0.292 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.106495e-01 0.292 0 0
Regulation of KIT signaling R-HSA-1433559 5.106495e-01 0.292 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 5.106495e-01 0.292 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 5.124006e-01 0.290 0 0
Interleukin-1 family signaling R-HSA-446652 5.124006e-01 0.290 0 0
Viral Messenger RNA Synthesis R-HSA-168325 5.160370e-01 0.287 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.160370e-01 0.287 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 5.172962e-01 0.286 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.172962e-01 0.286 0 0
Antigen processing-Cross presentation R-HSA-1236975 5.172962e-01 0.286 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.207849e-01 0.283 0 0
Cleavage of the damaged purine R-HSA-110331 5.212182e-01 0.283 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.212182e-01 0.283 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.212182e-01 0.283 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.212182e-01 0.283 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.297092e-01 0.276 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.297092e-01 0.276 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.297092e-01 0.276 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.297092e-01 0.276 0 0
DCC mediated attractive signaling R-HSA-418885 5.297092e-01 0.276 0 0
DNA Damage Reversal R-HSA-73942 5.297092e-01 0.276 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 5.306943e-01 0.275 0 0
TCR signaling R-HSA-202403 5.317949e-01 0.274 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 5.332216e-01 0.273 0 0
Depurination R-HSA-73927 5.332216e-01 0.273 0 0
Elastic fibre formation R-HSA-1566948 5.332216e-01 0.273 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 5.351181e-01 0.272 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.353861e-01 0.271 0 0
Peptide chain elongation R-HSA-156902 5.370391e-01 0.270 0 0
Generic Transcription Pathway R-HSA-212436 5.417633e-01 0.266 0 0
IGF1R signaling cascade R-HSA-2428924 5.444973e-01 0.264 0 0
Plasma lipoprotein clearance R-HSA-8964043 5.450175e-01 0.264 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.450175e-01 0.264 0 0
ER-Phagosome pathway R-HSA-1236974 5.450616e-01 0.264 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.480276e-01 0.261 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 5.480276e-01 0.261 0 0
Fructose catabolism R-HSA-70350 5.480276e-01 0.261 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.480276e-01 0.261 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.480276e-01 0.261 0 0
Attachment and Entry R-HSA-9678110 5.480276e-01 0.261 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.501327e-01 0.260 0 0
Neurotransmitter release cycle R-HSA-112310 5.530116e-01 0.257 0 0
Downstream TCR signaling R-HSA-202424 5.530116e-01 0.257 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 5.531673e-01 0.257 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 5.537655e-01 0.257 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.566038e-01 0.254 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 5.566038e-01 0.254 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 5.566038e-01 0.254 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.566038e-01 0.254 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 5.566038e-01 0.254 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 5.566038e-01 0.254 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 5.656336e-01 0.247 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 5.656336e-01 0.247 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.656336e-01 0.247 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 5.656336e-01 0.247 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 5.656336e-01 0.247 0 0
Heme assimilation R-HSA-9927020 5.656336e-01 0.247 0 0
Transcriptional regulation of testis differentiation R-HSA-9690406 5.656336e-01 0.247 0 0
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518 5.656336e-01 0.247 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.656336e-01 0.247 0 0
tRNA modification in the mitochondrion R-HSA-6787450 5.656336e-01 0.247 0 0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) R-HSA-9651496 5.656336e-01 0.247 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 5.665240e-01 0.247 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 5.679789e-01 0.246 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 5.679789e-01 0.246 0 0
IRE1alpha activates chaperones R-HSA-381070 5.686876e-01 0.245 0 0
RAF/MAP kinase cascade R-HSA-5673001 5.693559e-01 0.245 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 5.740533e-01 0.241 0 0
EPH-Ephrin signaling R-HSA-2682334 5.764101e-01 0.239 0 0
HIV Transcription Initiation R-HSA-167161 5.791417e-01 0.237 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 5.791417e-01 0.237 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.791417e-01 0.237 0 0
Intra-Golgi traffic R-HSA-6811438 5.791417e-01 0.237 0 0
Negative regulation of MAPK pathway R-HSA-5675221 5.791417e-01 0.237 0 0
Translation of Structural Proteins R-HSA-9683701 5.791417e-01 0.237 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 5.808839e-01 0.236 0 0
Transcription of the HIV genome R-HSA-167172 5.808839e-01 0.236 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 5.825548e-01 0.235 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 5.825548e-01 0.235 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 5.825548e-01 0.235 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 5.825548e-01 0.235 0 0
Signaling by Hippo R-HSA-2028269 5.825548e-01 0.235 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 5.825548e-01 0.235 0 0
Catecholamine biosynthesis R-HSA-209905 5.825548e-01 0.235 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.825548e-01 0.235 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.825548e-01 0.235 0 0
Selenoamino acid metabolism R-HSA-2408522 5.838361e-01 0.234 0 0
Eukaryotic Translation Initiation R-HSA-72613 5.876894e-01 0.231 0 0
Cap-dependent Translation Initiation R-HSA-72737 5.876894e-01 0.231 0 0
MTOR signalling R-HSA-165159 5.900915e-01 0.229 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.900915e-01 0.229 0 0
Activation of GABAB receptors R-HSA-991365 5.900915e-01 0.229 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.900915e-01 0.229 0 0
GABA B receptor activation R-HSA-977444 5.900915e-01 0.229 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 5.900915e-01 0.229 0 0
Depyrimidination R-HSA-73928 5.900915e-01 0.229 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 5.983735e-01 0.223 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 5.983735e-01 0.223 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 5.983735e-01 0.223 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.988178e-01 0.223 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.988178e-01 0.223 0 0
Platelet sensitization by LDL R-HSA-432142 5.988178e-01 0.223 0 0
Ephrin signaling R-HSA-3928664 5.988178e-01 0.223 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 5.988178e-01 0.223 0 0
Organic anion transport by SLC5/17/25 transporters R-HSA-428643 5.988178e-01 0.223 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 6.001784e-01 0.222 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.008279e-01 0.221 0 0
Signaling by SCF-KIT R-HSA-1433557 6.008279e-01 0.221 0 0
Eukaryotic Translation Termination R-HSA-72764 6.064980e-01 0.217 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 6.069372e-01 0.217 0 0
ECM proteoglycans R-HSA-3000178 6.069372e-01 0.217 0 0
Signaling by WNT R-HSA-195721 6.087996e-01 0.216 0 0
Netrin-1 signaling R-HSA-373752 6.113509e-01 0.214 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.144481e-01 0.212 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 6.144481e-01 0.212 0 0
Translesion Synthesis by POLH R-HSA-110320 6.144481e-01 0.212 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.144481e-01 0.212 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.144481e-01 0.212 0 0
Diseases of hemostasis R-HSA-9671793 6.144481e-01 0.212 0 0
The NLRP3 inflammasome R-HSA-844456 6.144481e-01 0.212 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.144481e-01 0.212 0 0
Translation R-HSA-72766 6.145728e-01 0.211 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 6.153787e-01 0.211 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 6.153787e-01 0.211 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 6.214231e-01 0.207 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.216609e-01 0.206 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.216609e-01 0.206 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.216609e-01 0.206 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.216609e-01 0.206 0 0
Ca2+ pathway R-HSA-4086398 6.236971e-01 0.205 0 0
Signaling by FGFR R-HSA-190236 6.281885e-01 0.202 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 6.294704e-01 0.201 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 6.294704e-01 0.201 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.294704e-01 0.201 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.294704e-01 0.201 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.294704e-01 0.201 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.294704e-01 0.201 0 0
Nephrin family interactions R-HSA-373753 6.294704e-01 0.201 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 6.317584e-01 0.199 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 6.317584e-01 0.199 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 6.317584e-01 0.199 0 0
Regulation of pyruvate metabolism R-HSA-9861718 6.317584e-01 0.199 0 0
Signaling by TGFBR3 R-HSA-9839373 6.317584e-01 0.199 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 6.334658e-01 0.198 0 0
HATs acetylate histones R-HSA-3214847 6.352467e-01 0.197 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.399616e-01 0.194 0 0
Iron uptake and transport R-HSA-917937 6.399616e-01 0.194 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 6.416445e-01 0.193 0 0
ABC-family proteins mediated transport R-HSA-382556 6.422178e-01 0.192 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.439083e-01 0.191 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.439083e-01 0.191 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.439083e-01 0.191 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 6.439083e-01 0.191 0 0
Phenylalanine metabolism R-HSA-8964208 6.439083e-01 0.191 0 0
Signaling by NTRKs R-HSA-166520 6.446815e-01 0.191 0 0
Signaling by NOTCH1 R-HSA-1980143 6.479067e-01 0.188 0 0
Interleukin-1 signaling R-HSA-9020702 6.491011e-01 0.188 0 0
GPER1 signaling R-HSA-9634597 6.513201e-01 0.186 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 6.513201e-01 0.186 0 0
Co-stimulation by CD28 R-HSA-389356 6.513201e-01 0.186 0 0
Post-translational protein modification R-HSA-597592 6.537050e-01 0.185 0 0
CS-GAG biosynthesis R-HSA-2022870 6.577845e-01 0.182 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.577845e-01 0.182 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 6.577845e-01 0.182 0 0
Serine metabolism R-HSA-977347 6.577845e-01 0.182 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.577845e-01 0.182 0 0
Attachment and Entry R-HSA-9694614 6.577845e-01 0.182 0 0
Signaling by PDGFR in disease R-HSA-9671555 6.577845e-01 0.182 0 0
Ribavirin ADME R-HSA-9755088 6.577845e-01 0.182 0 0
Assembly Of The HIV Virion R-HSA-175474 6.577845e-01 0.182 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.607868e-01 0.180 0 0
Integrin cell surface interactions R-HSA-216083 6.634209e-01 0.178 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 6.692187e-01 0.174 0 0
Azathioprine ADME R-HSA-9748787 6.700460e-01 0.174 0 0
PI3K Cascade R-HSA-109704 6.700460e-01 0.174 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 6.711207e-01 0.173 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.711207e-01 0.173 0 0
FGFR2 alternative splicing R-HSA-6803529 6.711207e-01 0.173 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.711207e-01 0.173 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 6.711207e-01 0.173 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.711207e-01 0.173 0 0
WNT ligand biogenesis and trafficking R-HSA-3238698 6.711207e-01 0.173 0 0
mTORC1-mediated signalling R-HSA-166208 6.711207e-01 0.173 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 6.711207e-01 0.173 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 6.711207e-01 0.173 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 6.711207e-01 0.173 0 0
Fructose metabolism R-HSA-5652084 6.711207e-01 0.173 0 0
Ethanol oxidation R-HSA-71384 6.711207e-01 0.173 0 0
LDL clearance R-HSA-8964038 6.711207e-01 0.173 0 0
Signal Transduction R-HSA-162582 6.718528e-01 0.173 0 0
Chromatin modifying enzymes R-HSA-3247509 6.778648e-01 0.169 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 6.784330e-01 0.168 0 0
Signaling by MET R-HSA-6806834 6.784330e-01 0.168 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 6.818019e-01 0.166 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.839380e-01 0.165 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 6.839380e-01 0.165 0 0
Mitochondrial mRNA modification R-HSA-9937008 6.839380e-01 0.165 0 0
Growth hormone receptor signaling R-HSA-982772 6.839380e-01 0.165 0 0
Formation of the ureteric bud R-HSA-9830674 6.839380e-01 0.165 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.839380e-01 0.165 0 0
Reproduction R-HSA-1474165 6.875326e-01 0.163 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 6.962565e-01 0.157 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.962565e-01 0.157 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 6.962565e-01 0.157 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 6.962565e-01 0.157 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.962565e-01 0.157 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.962565e-01 0.157 0 0
Nucleotide biosynthesis R-HSA-8956320 6.965980e-01 0.157 0 0
Cytoprotection by HMOX1 R-HSA-9707564 7.000119e-01 0.155 0 0
Interferon gamma signaling R-HSA-877300 7.037302e-01 0.153 0 0
Translation initiation complex formation R-HSA-72649 7.050471e-01 0.152 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 7.050471e-01 0.152 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.050471e-01 0.152 0 0
Cellular response to chemical stress R-HSA-9711123 7.063096e-01 0.151 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 7.080956e-01 0.150 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 7.080956e-01 0.150 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 7.080956e-01 0.150 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 7.080956e-01 0.150 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.080956e-01 0.150 0 0
Tight junction interactions R-HSA-420029 7.080956e-01 0.150 0 0
Laminin interactions R-HSA-3000157 7.080956e-01 0.150 0 0
HDACs deacetylate histones R-HSA-3214815 7.132993e-01 0.147 0 0
Signaling by EGFR in Cancer R-HSA-1643713 7.194740e-01 0.143 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.194740e-01 0.143 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.194740e-01 0.143 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 7.194740e-01 0.143 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 7.194740e-01 0.143 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 7.213571e-01 0.142 0 0
Signaling by EGFR R-HSA-177929 7.213571e-01 0.142 0 0
Inositol phosphate metabolism R-HSA-1483249 7.247222e-01 0.140 0 0
Hemostasis R-HSA-109582 7.285467e-01 0.138 0 0
IRS-mediated signalling R-HSA-112399 7.292231e-01 0.137 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.292231e-01 0.137 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.304095e-01 0.136 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 7.304095e-01 0.136 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 7.304095e-01 0.136 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 7.304095e-01 0.136 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.304095e-01 0.136 0 0
Cristae formation R-HSA-8949613 7.304095e-01 0.136 0 0
Signaling by FGFR3 in disease R-HSA-5655332 7.304095e-01 0.136 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 7.304095e-01 0.136 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.304095e-01 0.136 0 0
Triglyceride biosynthesis R-HSA-75109 7.304095e-01 0.136 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 7.304095e-01 0.136 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.304095e-01 0.136 0 0
Synthesis of PE R-HSA-1483213 7.304095e-01 0.136 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 7.304095e-01 0.136 0 0
Insulin processing R-HSA-264876 7.304095e-01 0.136 0 0
Disorders of transmembrane transporters R-HSA-5619115 7.322147e-01 0.135 0 0
Pyruvate metabolism R-HSA-70268 7.335001e-01 0.135 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 7.369000e-01 0.133 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 7.369000e-01 0.133 0 0
Chromatin organization R-HSA-4839726 7.400033e-01 0.131 0 0
HIV elongation arrest and recovery R-HSA-167287 7.409194e-01 0.130 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.409194e-01 0.130 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.409194e-01 0.130 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 7.409194e-01 0.130 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 7.409194e-01 0.130 0 0
Insulin receptor recycling R-HSA-77387 7.409194e-01 0.130 0 0
Pyroptosis R-HSA-5620971 7.409194e-01 0.130 0 0
Inflammasomes R-HSA-622312 7.409194e-01 0.130 0 0
DNA methylation R-HSA-5334118 7.510201e-01 0.124 0 0
DARPP-32 events R-HSA-180024 7.510201e-01 0.124 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.510201e-01 0.124 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.510201e-01 0.124 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 7.510201e-01 0.124 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.516978e-01 0.124 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.516978e-01 0.124 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.516978e-01 0.124 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.516978e-01 0.124 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.516978e-01 0.124 0 0
GABA receptor activation R-HSA-977443 7.516978e-01 0.124 0 0
tRNA Aminoacylation R-HSA-379724 7.516978e-01 0.124 0 0
Signaling by Retinoic Acid R-HSA-5362517 7.516978e-01 0.124 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 7.521375e-01 0.124 0 0
Infectious disease R-HSA-5663205 7.545652e-01 0.122 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 7.581129e-01 0.120 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.586830e-01 0.120 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 7.603524e-01 0.119 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.607277e-01 0.119 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 7.607277e-01 0.119 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.607277e-01 0.119 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 7.607277e-01 0.119 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 7.607277e-01 0.119 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.607277e-01 0.119 0 0
Activation of BH3-only proteins R-HSA-114452 7.607277e-01 0.119 0 0
Rab regulation of trafficking R-HSA-9007101 7.628818e-01 0.118 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 7.639714e-01 0.117 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 7.644910e-01 0.117 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.657734e-01 0.116 0 0
Heme signaling R-HSA-9707616 7.657734e-01 0.116 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.657734e-01 0.116 0 0
Signaling by Insulin receptor R-HSA-74752 7.697143e-01 0.114 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.700573e-01 0.113 0 0
EGFR downregulation R-HSA-182971 7.700573e-01 0.113 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 7.729971e-01 0.112 0 0
Insulin receptor signalling cascade R-HSA-74751 7.791508e-01 0.108 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 7.862608e-01 0.104 0 0
Regulation of necroptotic cell death R-HSA-5675482 7.876410e-01 0.104 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 7.876410e-01 0.104 0 0
Respiratory electron transport R-HSA-611105 7.931525e-01 0.101 0 0
Potential therapeutics for SARS R-HSA-9679191 7.958274e-01 0.099 0 0
CS/DS degradation R-HSA-2024101 7.959227e-01 0.099 0 0
Effects of PIP2 hydrolysis R-HSA-114508 7.959227e-01 0.099 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 7.959227e-01 0.099 0 0
Heme degradation R-HSA-189483 7.959227e-01 0.099 0 0
Potassium Channels R-HSA-1296071 7.967361e-01 0.099 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 8.038820e-01 0.095 0 0
eNOS activation R-HSA-203615 8.038820e-01 0.095 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 8.038820e-01 0.095 0 0
Mitophagy R-HSA-5205647 8.038820e-01 0.095 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 8.038820e-01 0.095 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.038820e-01 0.095 0 0
Regulated Necrosis R-HSA-5218859 8.039086e-01 0.095 0 0
Innate Immune System R-HSA-168249 8.056167e-01 0.094 0 0
Regulation of insulin secretion R-HSA-422356 8.067792e-01 0.093 0 0
Immune System R-HSA-168256 8.072561e-01 0.093 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.097002e-01 0.092 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 8.115313e-01 0.091 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 8.115313e-01 0.091 0 0
Oncogene Induced Senescence R-HSA-2559585 8.115313e-01 0.091 0 0
Muscle contraction R-HSA-397014 8.133374e-01 0.090 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.188827e-01 0.087 0 0
RNA Polymerase III Transcription R-HSA-74158 8.188827e-01 0.087 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.188827e-01 0.087 0 0
Metabolism of porphyrins R-HSA-189445 8.208277e-01 0.086 0 0
Voltage gated Potassium channels R-HSA-1296072 8.259478e-01 0.083 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 8.259478e-01 0.083 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.259478e-01 0.083 0 0
Phenylalanine and tyrosine metabolism R-HSA-8963691 8.259478e-01 0.083 0 0
Cellular response to starvation R-HSA-9711097 8.270513e-01 0.082 0 0
Viral mRNA Translation R-HSA-192823 8.300700e-01 0.081 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 8.327377e-01 0.079 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 8.327377e-01 0.079 0 0
Adipogenesis R-HSA-9843745 8.345422e-01 0.079 0 0
Signaling by ERBB4 R-HSA-1236394 8.364262e-01 0.078 0 0
Circadian clock R-HSA-9909396 8.383513e-01 0.077 0 0
Degradation of the extracellular matrix R-HSA-1474228 8.383513e-01 0.077 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 8.386901e-01 0.076 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 8.392631e-01 0.076 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.392631e-01 0.076 0 0
Pentose phosphate pathway R-HSA-71336 8.392631e-01 0.076 0 0
Signaling by ALK R-HSA-201556 8.392631e-01 0.076 0 0
Disease R-HSA-1643685 8.439298e-01 0.074 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 8.455343e-01 0.073 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 8.455343e-01 0.073 0 0
HIV Transcription Elongation R-HSA-167169 8.455343e-01 0.073 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.455343e-01 0.073 0 0
Diseases of Immune System R-HSA-5260271 8.455343e-01 0.073 0 0
rRNA processing in the mitochondrion R-HSA-8868766 8.455343e-01 0.073 0 0
Interleukin-2 family signaling R-HSA-451927 8.455343e-01 0.073 0 0
Generation of second messenger molecules R-HSA-202433 8.455343e-01 0.073 0 0
Translation of Structural Proteins R-HSA-9694635 8.507869e-01 0.070 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 8.509117e-01 0.070 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 8.515612e-01 0.070 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.515612e-01 0.070 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 8.515612e-01 0.070 0 0
FLT3 Signaling R-HSA-9607240 8.515612e-01 0.070 0 0
Stimuli-sensing channels R-HSA-2672351 8.548026e-01 0.068 0 0
Nuclear Receptor transcription pathway R-HSA-383280 8.553128e-01 0.068 0 0
G alpha (12/13) signalling events R-HSA-416482 8.553128e-01 0.068 0 0
SLC-mediated transport of organic anions R-HSA-9955298 8.553128e-01 0.068 0 0
Scavenging by Class A Receptors R-HSA-3000480 8.573533e-01 0.067 0 0
Heme biosynthesis R-HSA-189451 8.573533e-01 0.067 0 0
SLC transporter disorders R-HSA-5619102 8.574322e-01 0.067 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 8.596913e-01 0.066 0 0
SARS-CoV-2-host interactions R-HSA-9705683 8.615153e-01 0.065 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 8.629198e-01 0.064 0 0
Metabolism of proteins R-HSA-392499 8.643656e-01 0.063 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.660338e-01 0.062 0 0
Amyloid fiber formation R-HSA-977225 8.681484e-01 0.061 0 0
Defective pyroptosis R-HSA-9710421 8.682693e-01 0.061 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.694919e-01 0.061 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.694919e-01 0.061 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.725444e-01 0.059 0 0
Cyclin D associated events in G1 R-HSA-69231 8.734104e-01 0.059 0 0
G1 Phase R-HSA-69236 8.734104e-01 0.059 0 0
EPHB-mediated forward signaling R-HSA-3928662 8.734104e-01 0.059 0 0
RMTs methylate histone arginines R-HSA-3214858 8.734104e-01 0.059 0 0
Methylation R-HSA-156581 8.734104e-01 0.059 0 0
Surfactant metabolism R-HSA-5683826 8.734104e-01 0.059 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.739764e-01 0.059 0 0
SARS-CoV Infections R-HSA-9679506 8.757713e-01 0.058 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 8.776878e-01 0.057 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 8.783512e-01 0.056 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.830994e-01 0.054 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.830994e-01 0.054 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.830994e-01 0.054 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.843699e-01 0.053 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 8.876626e-01 0.052 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 8.876626e-01 0.052 0 0
Extracellular matrix organization R-HSA-1474244 8.897906e-01 0.051 0 0
Mitochondrial biogenesis R-HSA-1592230 8.920628e-01 0.050 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 8.962623e-01 0.048 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 8.962623e-01 0.048 0 0
Signaling by FGFR2 in disease R-HSA-5655253 9.003124e-01 0.046 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.033303e-01 0.044 0 0
Meiotic recombination R-HSA-912446 9.042046e-01 0.044 0 0
Complex IV assembly R-HSA-9864848 9.042046e-01 0.044 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.042046e-01 0.044 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.042046e-01 0.044 0 0
The phototransduction cascade R-HSA-2514856 9.042046e-01 0.044 0 0
Death Receptor Signaling R-HSA-73887 9.098388e-01 0.041 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.115397e-01 0.040 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.125280e-01 0.040 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.125280e-01 0.040 0 0
Neddylation R-HSA-8951664 9.160875e-01 0.038 0 0
HCMV Late Events R-HSA-9610379 9.164423e-01 0.038 0 0
Mitochondrial protein degradation R-HSA-9837999 9.179635e-01 0.037 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.183140e-01 0.037 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 9.185456e-01 0.037 0 0
Ion homeostasis R-HSA-5578775 9.215043e-01 0.036 0 0
Metabolism of amine-derived hormones R-HSA-209776 9.215043e-01 0.036 0 0
Digestion R-HSA-8935690 9.215043e-01 0.036 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 9.215043e-01 0.036 0 0
Synthesis of PA R-HSA-1483166 9.245702e-01 0.034 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.255247e-01 0.034 0 0
Peroxisomal protein import R-HSA-9033241 9.303480e-01 0.031 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.303480e-01 0.031 0 0
Triglyceride metabolism R-HSA-8979227 9.303480e-01 0.031 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.303480e-01 0.031 0 0
Regulation of beta-cell development R-HSA-186712 9.303480e-01 0.031 0 0
RAB geranylgeranylation R-HSA-8873719 9.330690e-01 0.030 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 9.330690e-01 0.030 0 0
Collagen degradation R-HSA-1442490 9.356838e-01 0.029 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.365238e-01 0.028 0 0
PI Metabolism R-HSA-1483255 9.387180e-01 0.027 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.394987e-01 0.027 0 0
Metabolism of nucleotides R-HSA-15869 9.401146e-01 0.027 0 0
Signaling by PTK6 R-HSA-8848021 9.406115e-01 0.027 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 9.406115e-01 0.027 0 0
Digestion and absorption R-HSA-8963743 9.406115e-01 0.027 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.406891e-01 0.027 0 0
Integration of energy metabolism R-HSA-163685 9.419629e-01 0.026 0 0
Ion transport by P-type ATPases R-HSA-936837 9.429321e-01 0.026 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 9.429321e-01 0.026 0 0
Adaptive Immune System R-HSA-1280218 9.455960e-01 0.024 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 9.462474e-01 0.024 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.477241e-01 0.023 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.483317e-01 0.023 0 0
Parasite infection R-HSA-9664407 9.483317e-01 0.023 0 0
Leishmania phagocytosis R-HSA-9664417 9.483317e-01 0.023 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.490508e-01 0.023 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.493647e-01 0.023 0 0
Kidney development R-HSA-9830369 9.493647e-01 0.023 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 9.544250e-01 0.020 0 0
MyD88-independent TLR4 cascade R-HSA-166166 9.544250e-01 0.020 0 0
COPII-mediated vesicle transport R-HSA-204005 9.550732e-01 0.020 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.568294e-01 0.019 0 0
Metal ion assimilation from the host R-HSA-9638482 9.568294e-01 0.019 0 0
Metabolism of cofactors R-HSA-8978934 9.568294e-01 0.019 0 0
Purine catabolism R-HSA-74259 9.585172e-01 0.018 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 9.601390e-01 0.018 0 0
Aspirin ADME R-HSA-9749641 9.601390e-01 0.018 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.626475e-01 0.017 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.631952e-01 0.016 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.631952e-01 0.016 0 0
Ion channel transport R-HSA-983712 9.651626e-01 0.015 0 0
Phospholipid metabolism R-HSA-1483257 9.666811e-01 0.015 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.686236e-01 0.014 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.710301e-01 0.013 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 9.724155e-01 0.012 0 0
Formation of the cornified envelope R-HSA-6809371 9.733327e-01 0.012 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.751094e-01 0.011 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.762706e-01 0.010 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 9.771992e-01 0.010 0 0
Parasitic Infection Pathways R-HSA-9824443 9.797866e-01 0.009 0 0
Leishmania infection R-HSA-9658195 9.797866e-01 0.009 0 0
G alpha (s) signalling events R-HSA-418555 9.808421e-01 0.008 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.818930e-01 0.008 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.819905e-01 0.008 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.819905e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.840822e-01 0.007 0 0
Mitochondrial translation R-HSA-5368287 9.850788e-01 0.007 0 0
Scavenging of heme from plasma R-HSA-2168880 9.853043e-01 0.006 0 0
Mitochondrial translation elongation R-HSA-5389840 9.858798e-01 0.006 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.858798e-01 0.006 0 0
Mitochondrial translation initiation R-HSA-5368286 9.869641e-01 0.006 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.869641e-01 0.006 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.869641e-01 0.006 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.869641e-01 0.006 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 9.874747e-01 0.005 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.874747e-01 0.005 0 0
G alpha (i) signalling events R-HSA-418594 9.881398e-01 0.005 0 0
Toll-like Receptor Cascades R-HSA-168898 9.897519e-01 0.004 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 9.898058e-01 0.004 0 0
RSV-host interactions R-HSA-9833110 9.901450e-01 0.004 0 0
Metabolism of amino acids and derivatives R-HSA-71291 9.906720e-01 0.004 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 9.911327e-01 0.004 0 0
Protein localization R-HSA-9609507 9.914372e-01 0.004 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 9.916013e-01 0.004 0 0
Mitochondrial translation termination R-HSA-5419276 9.919305e-01 0.004 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 9.919305e-01 0.004 0 0
PPARA activates gene expression R-HSA-1989781 9.920157e-01 0.003 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.922467e-01 0.003 0 0
Bacterial Infection Pathways R-HSA-9824439 9.922890e-01 0.003 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.925560e-01 0.003 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.928427e-01 0.003 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 9.931232e-01 0.003 0 0
Initial triggering of complement R-HSA-166663 9.936519e-01 0.003 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 9.939008e-01 0.003 0 0
Peptide hormone metabolism R-HSA-2980736 9.945906e-01 0.002 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 9.950065e-01 0.002 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 9.950065e-01 0.002 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 9.955714e-01 0.002 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 9.955714e-01 0.002 0 0
Drug ADME R-HSA-9748784 9.958360e-01 0.002 0 0
Transport of small molecules R-HSA-382551 9.960184e-01 0.002 0 0
Regulation of Complement cascade R-HSA-977606 9.960725e-01 0.002 0 0
G alpha (q) signalling events R-HSA-416476 9.962098e-01 0.002 0 0
Nucleotide catabolism R-HSA-8956319 9.967850e-01 0.001 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.970968e-01 0.001 0 0
Cardiac conduction R-HSA-5576891 9.971489e-01 0.001 0 0
Diseases of glycosylation R-HSA-3781865 9.972386e-01 0.001 0 0
Complement cascade R-HSA-166658 9.984983e-01 0.001 0 0
Visual phototransduction R-HSA-2187338 9.986140e-01 0.001 0 0
Keratinization R-HSA-6805567 9.987929e-01 0.001 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.991858e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.996379e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.997218e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.997900e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.998478e-01 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 9.998596e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999822e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999848e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999934e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999948e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999985e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.999998e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999999e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999999e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999999e-01 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways