PLK3
Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Motif clusters with count ≥ 10 are shown
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| substrate_uniprot | site | source | substrate_genes | site_seq |
|---|---|---|---|---|
| A0MZ66 | S473 | Sugiyama | SHTN1 KIAA1598 | LGtLNKSTSSRsLKsLDPENsEtELERILRRRKVtAEADss |
| A5A3E0 | S1065 | Sugiyama | POTEF A26C1B | ILASLSTFQQMWISKQEyDEsGPsIVHRKCL__________ |
| A5A3E0 | S1068 | Sugiyama | POTEF A26C1B | SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________ |
| A5A3E0 | S939 | Sugiyama | POTEF A26C1B | VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE |
| A5A3E0 | Y940 | Sugiyama | POTEF A26C1B | ALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPEA |
| A6NMY6 | S161 | Sugiyama | ANXA2P2 ANX2L2 ANX2P2 LPC2B | QEINRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAE |
| A6NMY6 | S164 | Sugiyama | ANXA2P2 ANX2L2 ANX2P2 LPC2B | NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGS |
| O00299 | S221 | Sugiyama | CLIC1 G6 NCC27 | EAFRGVHRYLsNAyAREEFAstCPDDEEIELAyEQVAKALK |
| O00410 | T32 | Sugiyama | IPO5 KPNB3 RANBP5 | YLLLGNLLsPDNVVRKQAEEtyENIPGQSKITFLLQAIRNT |
| O00488 | S98 | Sugiyama | ZNF593 ZT86 | THFRSKDHKKRLKQLsVEPysQEEAERAAGMGSYVPPRRLA |
| O14950 | T128 | Sugiyama | MYL12B MRLC2 MYLC2B | ACFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPI |
| O14950 | T129 | Sugiyama | MYL12B MRLC2 MYLC2B | CFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPID |
| O14980 | S1031 | Sugiyama | XPO1 CRM1 | FKEHLRDFLVQIKEFAGEDtsDLFLEEREIALRQADEEKHK |
| O15230 | T439 | Sugiyama | LAMA5 KIAA0533 KIAA1907 | PLDsPHVCRRCNCESDFTDGtCEDLTGRCyCRPNFSGERCD |
| O43290 | T626 | Sugiyama | SART1 | WSTVNLDEEKQQQDFSASsTtILDEEPIVNRGLAAALLLCQ |
| O43390 | T134 | Sugiyama | HNRNPR HNRPR | KVQESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS |
| O43390 | Y136 | Sugiyama | HNRNPR HNRPR | QESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY |
| O43719 | S642 | Sugiyama | HTATSF1 | EDsDEKEEEEDtyEKVFDDEsDEKEDEEyADEKGLEAADKK |
| O43719 | S676 | Sugiyama | HTATSF1 | LEAADKKAEEGDADEKLFEEsDDKEDEDADGKEVEDADEKL |
| O43719 | S702 | Sugiyama | HTATSF1 | EDADGKEVEDADEKLFEDDDsNEKLFDEEEDssEKLFDDsD |
| O43719 | S713 | Sugiyama | HTATSF1 | DEKLFEDDDsNEKLFDEEEDssEKLFDDsDERGTLGGFGSV |
| O43823 | S125 | Sugiyama | AKAP8 AKAP95 | KEGGRGGsGGGGEGIQDREssFRFQPFESYDSRPCLPEHNP |
| O43852 | S125 | Sugiyama | CALU | IyEDVERQWKGHDLNEDGLVsWEEyKNATYGYVLDDPDPDD |
| O43852 | S261 | Sugiyama | CALU | RDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLVyEsDQNK |
| O43852 | S44 | EPSD|PSP | CALU | KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL |
| O43852 | T177 | EPSD|PSP | CALU | ERRFKMADKDGDLIATKEEFtAFLHPEEyDyMKDIVVQEtM |
| O43852 | T196 | EPSD|PSP|Sugiyama | CALU | FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD |
| O43852 | T254 | EPSD|PSP | CALU | REQFVEFRDKNRDGKMDKEEtKDWILPsDyDHAEAEARHLV |
| O43852 | T60 | EPSD|PSP | CALU | NDAQsFDyDHDAFLGAEEAKtFDQLtPEEsKERLGKIVSKI |
| O43852 | T89 | Sugiyama | CALU | sKERLGKIVSKIDGDKDGFVtVDELKDWIKFAQKRWIyEDV |
| O60231 | S103 | Sugiyama | DHX16 DBP2 DDX16 KIAA0577 PRP2 | AEREARALLEKNRSYRLLEDsEEssEEtVsRAGsSLQKKRK |
| O60231 | S107 | Sugiyama | DHX16 DBP2 DDX16 KIAA0577 PRP2 | ARALLEKNRSYRLLEDsEEssEEtVsRAGsSLQKKRKKRKH |
| O60506 | T131 | Sugiyama | SYNCRIP HNRPQ NSAP1 | KVADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS |
| O60506 | Y133 | Sugiyama | SYNCRIP HNRPQ NSAP1 | ADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY |
| O60763 | S776 | Sugiyama | USO1 VDP | KDSMIENMKSSQtSGTNEQSsAIVSARDSEQVAELKQELAT |
| O60763 | S881 | Sugiyama | USO1 VDP | KNEIKALSEERTAIKEQLDssNsTIAILQTEKDKLELEITD |
| O60841 | S190 | Sugiyama | EIF5B IF2 KIAA0741 | NsKKIKERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGP |
| O60841 | S222 | Sugiyama | EIF5B IF2 KIAA0741 | KNQKNKPGPNIEsGNEDDDAsFKIKTVAQKKAEKKERERKK |
| O75534 | T761 | Sugiyama | CSDE1 D1S155E KIAA0885 NRU UNR | GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN |
| O75821 | S28 | Sugiyama | EIF3G EIF3S4 | sKPsWADQVEEEGEDDKCVtsELLKGIPLAtGDtsPEPELL |
| O75821 | T27 | Sugiyama | EIF3G EIF3S4 | DsKPsWADQVEEEGEDDKCVtsELLKGIPLAtGDtsPEPEL |
| O75822 | S127 | Sugiyama | EIF3J EIF3S1 PRO0391 | VLtPEEQLADKLRLKKLQEEsDLELAKEtFGVNNAVyGIDA |
| O95218 | S181 | Sugiyama | ZRANB2 ZIS ZNF265 | DEDLsKyKLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRR |
| O95218 | S188 | Sugiyama | ZRANB2 ZIS ZNF265 | KLDEDEDEDDADLsKyNLDAsEEEDsNKKKSNRRSRSKSRS |
| O95757 | S599 | Sugiyama | HSPA4L APG1 HSPH3 OSP94 | sIDLPIQssLCRQLGQDLLNsyIENEGKMIMQDKLEKERND |
| O96017 | S62 | GPS6|SIGNOR|EPSD|PSP | CHEK2 CDS1 CHK2 RAD53 | STSTMPNSsQSSHSSSGTLSsLETVStQELYsIPEDQEPED |
| O96017 | S73 | GPS6|SIGNOR|EPSD|PSP | CHEK2 CDS1 CHK2 RAD53 | SHSSSGTLSsLETVStQELYsIPEDQEPEDQEPEEPTPAPW |
| O96017 | T68 | EPSD | CHEK2 CDS1 CHK2 RAD53 | NSsQSSHSSSGTLSsLETVStQELYsIPEDQEPEDQEPEEP |
| P00338 | S105 | Sugiyama | LDHA PIG19 | VTANsKLVIItAGARQQEGEsRLNLVQRNVNIFKFIIPNVV |
| P00338 | S161 | Sugiyama | LDHA PIG19 | DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH |
| P01130 | T315 | Sugiyama | LDLR | VCNMARDCRDWSDEPIKECGtNECLDNNGGCSHVCNDLKIG |
| P02786 | S151 | Sugiyama | TFRC | LsEKLDstDFTGtIKLLNENsyVPREAGsQKDENLALyVEN |
| P04075 | S17 | Sugiyama | ALDOA ALDA | ____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst |
| P04075 | S336 | Sugiyama | ALDOA ALDA | GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs |
| P04075 | S36 | Sugiyama | ALDOA ALDA | LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR |
| P04075 | T37 | Sugiyama | ALDOA ALDA | sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR |
| P04083 | S189 | Sugiyama | ANXA1 ANX1 LPC1 | tsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsDARALyEA |
| P04083 | S201 | Sugiyama | ANXA1 ANX1 LPC1 | LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF |
| P04083 | T169 | Sugiyama | ANXA1 ANX1 LPC1 | IRDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRs |
| P04406 | S241 | Sugiyama | GAPDH GAPD CDABP0047 OK/SW-cl.12 | IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV |
| P04637 | S20 | GPS6|SIGNOR|iPTMNet|EPSD|PSP | TP53 P53 | _MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQAM |
| P04792 | S82 | Sugiyama | HSPB1 HSP27 HSP28 | AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN |
| P05198 | S219 | Sugiyama | EIF2S1 EIF2A | CYGYEGIDAVKEALRAGLNCsTENMPIKINLIAPPRYVMTT |
| P05198 | T284 | Sugiyama | EIF2S1 EIF2A | EKRGVFNVQMEPKVVtDtDEtELARQMERLERENAEVDGDD |
| P05386 | S101 | Sugiyama | RPLP1 RRP1 | APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______ |
| P05386 | S104 | Sugiyama | RPLP1 RRP1 | tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________ |
| P05387 | S102 | Sugiyama | RPLP2 D11S2243E RPP2 | PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______ |
| P05387 | S105 | Sugiyama | RPLP2 D11S2243E RPP2 | GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________ |
| P05388 | S304 | Sugiyama | RPLP0 | AttAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______ |
| P05388 | S307 | Sugiyama | RPLP0 | AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________ |
| P05412 | S63 | GPS6|SIGNOR|EPSD|PSP | JUN | ADPVGSLKPHLRAKNsDLLtsPDVGLLKLAsPELERLIIQS |
| P05412 | S73 | GPS6|SIGNOR|EPSD|PSP | JUN | LRAKNsDLLtsPDVGLLKLAsPELERLIIQSSNGHItttPt |
| P05455 | S225 | Sugiyama | SSB | LRAKQEQEAKQKLEEDAEMKsLEEKIGCLLKFSGDLDDQTC |
| P05556 | S503 | Sugiyama | ITGB1 FNRB MDF2 MSK12 | TFECGACRCNEGRVGRHCECstDEVNsEDMDAYCRKENSSE |
| P05556 | S509 | Sugiyama | ITGB1 FNRB MDF2 MSK12 | CRCNEGRVGRHCECstDEVNsEDMDAYCRKENSSEICSNNG |
| P05556 | T504 | Sugiyama | ITGB1 FNRB MDF2 MSK12 | FECGACRCNEGRVGRHCECstDEVNsEDMDAYCRKENSSEI |
| P05787 | S280 | Sugiyama | KRT8 CYK8 | IAEVKAQyEDIANRsRAEAEsMyQIKyEELQsLAGKHGDDL |
| P05787 | S291 | Sugiyama | KRT8 CYK8 | ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN |
| P05787 | S477 | Sugiyama | KRT8 CYK8 | SSRAVVVKKIETRDGKLVsEssDVLPK______________ |
| P06733 | S268 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | ASEFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyP |
| P06733 | T205 | Sugiyama | ENO1 ENO1L1 MBPB1 MPB1 | GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE |
| P06748 | S4 | EPSD|PSP | NPM1 NPM | _________________MEDsMDMDMsPLRPQNyLFGCELK |
| P07195 | S106 | Sugiyama | LDHB | VtANSKIVVVtAGVRQQEGEsRLNLVQRNVNVFKFIIPQIV |
| P07195 | S162 | Sugiyama | LDHB | DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH |
| P07195 | S44 | Sugiyama | LDHB | ITVVGVGQVGMACAISILGKsLADELALVDVLEDKLKGEMM |
| P07195 | T18 | Sugiyama | LDHB | ___MATLKEKLIAPVAEEEAtVPNNKITVVGVGQVGMACAI |
| P07195 | T323 | Sugiyama | LDHB | sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________ |
| P07237 | S427 | Sugiyama | P4HB ERBA2L PDI PDIA1 PO4DB | WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP |
| P07237 | S88 | Sugiyama | P4HB ERBA2L PDI PDIA1 PO4DB | GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG |
| P07237 | T428 | Sugiyama | P4HB ERBA2L PDI PDIA1 PO4DB | DKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFPA |
| P07237 | T453 | Sugiyama | P4HB ERBA2L PDI PDIA1 PO4DB | EAVKVHsFPtLKFFPAsADRtVIDyNGERtLDGFKKFLESG |
| P07237 | T85 | Sugiyama | P4HB ERBA2L PDI PDIA1 PO4DB | KAAGKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFF |
| P07355 | S161 | Sugiyama | ANXA2 ANX2 ANX2L4 CAL1H LPC2D | QEINRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAE |
| P07355 | S164 | Sugiyama | ANXA2 ANX2 ANX2L4 CAL1H LPC2D | NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGs |
| P07355 | S184 | Sugiyama | ANXA2 ANX2 ANX2L4 CAL1H LPC2D | sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK |
| P07437 | S75 | Sugiyama | TUBB TUBB5 OK/SW-cl.56 | tGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs |
| P07437 | T72 | Sugiyama | TUBB TUBB5 OK/SW-cl.56 | NEAtGGKyVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF |
| P07864 | S161 | Sugiyama | LDHC LDH3 LDHX | DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH |
| P07900 | S263 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | EEKEKEEKEsEDKPEIEDVGsDEEEEKKDGDKKKKKKIKEK |
| P07900 | S399 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK |
| P07900 | S50 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL |
| P07900 | S52 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | LIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDs |
| P07900 | S53 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG |
| P07900 | S623 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | tyGWTANMERIMKAQALRDNstMGyMAAKKHLEINPDHsII |
| P07900 | S641 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD |
| P07900 | T195 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG |
| P07900 | T305 | Sugiyama | HSP90AA1 HSP90A HSPC1 HSPCA | IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA |
| P08238 | S391 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK |
| P08238 | S45 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL |
| P08238 | S460 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | GIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQ |
| P08238 | S462 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs |
| P08238 | S468 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG |
| P08238 | S48 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG |
| P08238 | S497 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | KEtQKsIyyItGEsKEQVANsAFVERVRKRGFEVVyMtEPI |
| P08238 | S718 | EPSD|PSP | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | EEPNAAVPDEIPPLEGDEDAsRMEEVD______________ |
| P08238 | T190 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG |
| P08238 | Y457 | Sugiyama | HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB | LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK |
| P08670 | S459 | Sugiyama | VIM | KRTLLIKtVEtRDGQVINEtsQHHDDLE_____________ |
| P08708 | S89 | Sugiyama | RPS17 RPS17L | ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL |
| P08708 | T102 | Sugiyama | RPS17 RPS17L | DNyVPEVsALDQEIIEVDPDtKEMLKLLDFGsLsNLQVtQP |
| P09382 | S63 | Sugiyama | LGALS1 | CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG |
| P09382 | T58 | Sugiyama | LGALS1 | DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF |
| P09661 | T250 | Sugiyama | SNRPA1 | PGRERRsGPtDDGEEEMEEDtVtNGS_______________ |
| P09874 | S786 | Sugiyama | PARP1 ADPRT PPOL | DNLLDIEVAySLLRGGsDDssKDPIDVNyEKLKTDIKVVDR |
| P0CG38 | S1065 | Sugiyama | POTEI | ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________ |
| P0CG38 | S1068 | Sugiyama | POTEI | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P0CG39 | S1028 | Sugiyama | POTEJ | ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________ |
| P0CG39 | S1031 | Sugiyama | POTEJ | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P0DPH7 | S287 | Sugiyama | TUBA3C TUBA2 | FPLAtyAPVIsAEKAyHEQLsVAEItNACFEPANQMVKCDP |
| P0DPH7 | S48 | Sugiyama | TUBA3C TUBA2 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| P0DPH7 | T292 | Sugiyama | TUBA3C TUBA2 | yAPVIsAEKAyHEQLsVAEItNACFEPANQMVKCDPRHGKY |
| P0DPH7 | T51 | Sugiyama | TUBA3C TUBA2 | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| P10809 | T105 | Sugiyama | HSPD1 HSP60 | DLKDKYKNIGAKLVQDVANNtNEEAGDGtttAtVLARSIAK |
| P10809 | T428 | Sugiyama | HSPD1 HSP60 | GtsDVEVNEKKDRVtDALNAtRAAVEEGIVLGGGCALLRCI |
| P11142 | T226 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK |
| P11142 | T586 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | DKQKILDKCNEIINWLDKNQtAEKEEFEHQQKELEKVCNPI |
| P11142 | T64 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ |
| P11142 | T66 | Sugiyama | HSPA8 HSC70 HSP73 HSPA10 | DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD |
| P11388 | T1343 | GPS6|SIGNOR|EPSD|PSP | TOP2A TOP2 | KTKFTMDLDsDEDFsDFDEKtDDEDFVPsDAsPPKtKTsPK |
| P12277 | S163 | Sugiyama | CKB CKBB | PPHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAE |
| P12277 | S164 | Sugiyama | CKB CKBB | PHCsRGERRAIEKLAVEALssLDGDLAGRyyALKsMtEAEQ |
| P13489 | S178 | Sugiyama | RNH1 PRI RNH | SCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKDSP |
| P13489 | S290 | Sugiyama | RNH1 PRI RNH | AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE |
| P13489 | T176 | Sugiyama | RNH1 PRI RNH | AASCEPLASVLRAKPDFKELtVsNNDINEAGVRVLCQGLKD |
| P13639 | S23 | Sugiyama | EEF2 EF2 | NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA |
| P13667 | S470 | Sugiyama | PDIA4 ERP70 ERP72 | FAIADEEDyAGEVKDLGLsEsGEDVNAAILDEsGKKFAMEP |
| P13798 | S185 | Sugiyama | APEH D3F15S2 D3S48E DNF15S2 | VAEKKRPKAEsFFQTKALDVsAsDDEIARLKKPDQAIKGDQ |
| P14314 | S108 | Sugiyama | PRKCSH G19P1 | PSNRVNDGVCDCCDGtDEyNsGVICENtCKEKGRKEREsLQ |
| P14314 | S126 | Sugiyama | PRKCSH G19P1 | yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE |
| P14314 | T469 | Sugiyama | PRKCSH G19P1 | WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt |
| P14625 | S106 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL |
| P14625 | S109 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN |
| P14625 | S306 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | TETVEEPMEEEEAAKEEKEEsDDEAAVEEEEEEKKPKTKKV |
| P14625 | S551 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | MKEKQDKIyFMAGsSRKEAEssPFVERLLKKGyEVIyLTEP |
| P14625 | T148 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | GNEELTVKIKCDKEKNLLHVtDtGVGMtREELVKNLGTIAK |
| P14625 | T150 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | EELTVKIKCDKEKNLLHVtDtGVGMtREELVKNLGTIAKsG |
| P14625 | T155 | Sugiyama | HSP90B1 GRP94 HSPC4 TRA1 | KIKCDKEKNLLHVtDtGVGMtREELVKNLGTIAKsGtsEFL |
| P14635 | S133 | EPSD|PSP | CCNB1 CCNB | EKLsPEPILVDTAsPsPMETsGCAPAEEDLCQAFsDVILAV |
| P15336 | T69 | SIGNOR|EPSD|PSP | ATF2 CREB2 CREBP1 | HEMtLKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELA |
| P15336 | T71 | GPS6|SIGNOR|EPSD|PSP | ATF2 CREB2 CREBP1 | MtLKFGPARNDsVIVADQtPtPtRFLKNCEEVGLFNELAsP |
| P15374 | S126 | Sugiyama | UCHL3 | NNKDKMHFESGSTLKKFLEEsVsMsPEERARyLENyDAIRV |
| P15374 | S128 | Sugiyama | UCHL3 | KDKMHFESGSTLKKFLEEsVsMsPEERARyLENyDAIRVtH |
| P15531 | S122 | Sugiyama | NME1 NDPKA NM23 | GtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDy |
| P15531 | S125 | Sugiyama | NME1 NDPKA NM23 | RGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELVDyTsC |
| P16333 | S96 | Sugiyama | NCK1 NCK | GIGKVKRKPsVPDsAsPADDsFVDPGERLyDLNMPAyVKFN |
| P17066 | T228 | Sugiyama | HSPA6 HSP70B' | DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR |
| P17096 | S103 | Sugiyama | HMGA1 HMGIY | PRGRPKKLEKEEEEGIsQEssEEEQ________________ |
| P17096 | S99 | Sugiyama | HMGA1 HMGIY | PGRKPRGRPKKLEKEEEEGIsQEssEEEQ____________ |
| P17980 | S186 | Sugiyama | PSMC3 TBP1 | tEyDsRVKAMEVDERPtEQysDIGGLDKQIQELVEAIVLPM |
| P17980 | T182 | Sugiyama | PSMC3 TBP1 | EtLPtEyDsRVKAMEVDERPtEQysDIGGLDKQIQELVEAI |
| P17987 | S544 | Sugiyama | TCP1 CCT1 CCTA | ILRIDDLIKLHPESKDDKHGsyEDAVHsGALND________ |
| P17987 | S551 | Sugiyama | TCP1 CCT1 CCTA | IKLHPESKDDKHGsyEDAVHsGALND_______________ |
| P17987 | Y545 | Sugiyama | TCP1 CCT1 CCTA | LRIDDLIKLHPESKDDKHGsyEDAVHsGALND_________ |
| P18669 | S14 | Sugiyama | PGAM1 PGAMA CDABP0006 | _______MAAYKLVLIRHGEsAWNLENRFsGWyDADLsPAG |
| P18669 | T146 | Sugiyama | PGAM1 PGAMA CDABP0006 | MEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIARALPF |
| P18827 | S285 | Sugiyama | SDC1 SDC | IFAVCLVGFMLYRMKKKDEGsysLEEPKQANGGAyQKPtKQ |
| P18827 | S287 | Sugiyama | SDC1 SDC | AVCLVGFMLYRMKKKDEGsysLEEPKQANGGAyQKPtKQEE |
| P18827 | Y286 | Sugiyama | SDC1 SDC | FAVCLVGFMLYRMKKKDEGsysLEEPKQANGGAyQKPtKQE |
| P19105 | T127 | Sugiyama | MYL12A MLCB MRLC3 RLC | ACFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPI |
| P19105 | T128 | Sugiyama | MYL12A MLCB MRLC3 RLC | CFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPID |
| P19338 | S356 | Sugiyama | NCL | LAVVDVRIGMTRKFGyVDFEsAEDLEKALELtGLKVFGNEI |
| P19338 | T583 | Sugiyama | NCL | sPNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARIVTD |
| P19338 | T584 | Sugiyama | NCL | PNARSQPSKTLFVKGLsEDttEEtLKEsFDGsVRARIVTDR |
| P20042 | S67 | Sugiyama | EIF2S2 EIF2B | EPtEDKDLEADEEDTRKKDAsDDLDDLNFFNQKKKKKKTKK |
| P20042 | T31 | Sugiyama | EIF2S2 EIF2B | tMsKKKKKKKKPFMLDEEGDtQtEEtQPsETKEVEPEPtED |
| P20290 | S201 | Sugiyama | BTF3 NACB OK/SW-cl.8 | AtGEDDDDEVPDLVENFDEAsKNEAN_______________ |
| P22059 | S389 | Sugiyama | OSBP OSBP1 | PENLGHKRtGsNIsGAssDIsLDEQyKHQLEETKKEKRTRI |
| P22234 | S35 | Sugiyama | PAICS ADE2 AIRC PAIS | EGKtKEVyELLDsPGKVLLQsKDQItAGNAARKNHLEGKAA |
| P22234 | T40 | Sugiyama | PAICS ADE2 AIRC PAIS | EVyELLDsPGKVLLQsKDQItAGNAARKNHLEGKAAISNKI |
| P22314 | S46 | Sugiyama | UBA1 A1S9T UBE1 | AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA |
| P23246 | S283 | Sugiyama | SFPQ PSF | GPGGRsEEKIsDsEGFKANLsLLRRPGEKTyTQRCRLFVGN |
| P23381 | S358 | Sugiyama | WARS1 IFI53 WARS WRS | TFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTKVNKHAFs |
| P23588 | S122 | Sugiyama | EIF4B | NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA |
| P23588 | S207 | Sugiyama | EIF4B | DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR |
| P25705 | S52 | Sugiyama | ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM | AARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETG |
| P25705 | S53 | Sugiyama | ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM | ARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETGR |
| P25705 | S65 | Sugiyama | ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM | KtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARVH |
| P25705 | T64 | Sugiyama | ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM | QKtGtAEMssILEERILGADtsVDLEETGRVLsIGDGIARV |
| P25786 | T11 | Sugiyama | PSMA1 HC2 NU PROS30 PSC2 | __________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ |
| P25788 | S243 | Sugiyama | PSMA3 HC8 PSC8 | GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________ |
| P25788 | S250 | Sugiyama | PSMA3 HC8 PSC8 | KDIREEAEKyAKEsLKEEDEsDDDNM_______________ |
| P26038 | S576 | Sugiyama | MSN | YKtLRQIRQGNTKQRIDEFEsM___________________ |
| P26373 | T107 | Sugiyama | RPL13 BBC1 OK/SW-cl.46 | HKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILF |
| P26639 | S522 | Sugiyama | TARS1 TARS | PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP |
| P26639 | S70 | Sugiyama | TARS1 TARS | WPEyIytRLEMYNILKAEHDsILAEKAEKDSKPIKVTLPDG |
| P26641 | T287 | Sugiyama | EEF1G EF1G PRO1608 | EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL |
| P27348 | S145 | Sugiyama | YWHAQ | YFRyLAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHP |
| P27348 | S156 | Sugiyama | YWHAQ | DDRKQtIDNsQGAyQEAFDIsKKEMQPTHPIRLGLALNFSV |
| P27348 | S37 | Sugiyama | YWHAQ | ERyDDMAtCMKAVtEQGAELsNEERNLLsVAyKNVVGGRRS |
| P27348 | Y149 | Sugiyama | YWHAQ | LAEVACGDDRKQtIDNsQGAyQEAFDIsKKEMQPTHPIRLG |
| P27540 | S57 | Sugiyama | ARNT BHLHE2 | VQRAIKRRPGLDFDDDGEGNsKFLRCDDDQMsNDKERFARs |
| P27797 | S189 | Sugiyama | CALR CRTC | THLytLIVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIK |
| P27797 | S193 | Sugiyama | CALR CRTC | tLIVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIKDPDA |
| P27797 | S195 | Sugiyama | CALR CRTC | IVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIKDPDAsK |
| P27797 | S214 | Sugiyama | CALR CRTC | GsLEDDWDFLPPKKIKDPDAsKPEDWDERAKIDDPtDsKPE |
| P27797 | S52 | Sugiyama | CALR CRTC | GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA |
| P27797 | T34 | Sugiyama | CALR CRTC | LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG |
| P27816 | T287 | Sugiyama | MAP4 | ATKTEVALAKDMEsPtKLDVtLAKDMQPSMESDMALVKDME |
| P28066 | S159 | Sugiyama | PSMA5 | VALLFGGVDEKGPQLFHMDPsGtFVQCDARAIGsAsEGAQs |
| P28066 | T161 | Sugiyama | PSMA5 | LLFGGVDEKGPQLFHMDPsGtFVQCDARAIGsAsEGAQssL |
| P28331 | S725 | Sugiyama | NDUFS1 | QTMAKCVKAVTEGAQAVEEPsIC__________________ |
| P29144 | S176 | Sugiyama | TPP2 | FDVANNGSsQANKLIKEELQsQVELLNsFEKKYSDPGPVYD |
| P29401 | T342 | Sugiyama | TKT | GQALAKLGHAsDRIIALDGDtKNstFsEIFKKEHPDRFIEC |
| P29692 | S44 | Sugiyama | EEF1D EF1D | RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs |
| P30084 | S107 | Sugiyama | ECHS1 | LTGGDKAFAAGADIKEMQNLsFQDCySSKFLKHWDHLTQVK |
| P30101 | S474 | Sugiyama | PDIA3 ERP57 ERP60 GRP58 | yFsPANKKLNPKKyEGGRELsDFIsyLQREAtNPPVIQEEK |
| P30101 | S478 | Sugiyama | PDIA3 ERP57 ERP60 GRP58 | ANKKLNPKKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKK |
| P30304 | S513 | GPS6|EPSD | CDC25A | DFKEDLKKFRTKSRtWAGEKsKREMYsRLKKL_________ |
| P30304 | S519 | GPS6|EPSD | CDC25A | KKFRTKSRtWAGEKsKREMYsRLKKL_______________ |
| P30304 | T80 | SIGNOR|EPSD|PSP | CDC25A | EQPLEVKNNSNLQRMGsSEstDsGFCLDsPGPLDSKENLEN |
| P30307 | S191 | GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP | CDC25C | TTVPKLDKNPNLGEDQAEEIsDELMEFsLKDQEAKVSRsGL |
| P30307 | S198 | GPS6|SIGNOR|ELM|iPTMNet|EPSD|PSP | CDC25C | KNPNLGEDQAEEIsDELMEFsLKDQEAKVSRsGLYRsPsMP |
| P30307 | S216 | SIGNOR|iPTMNet|EPSD | CDC25C | EFsLKDQEAKVSRsGLYRsPsMPENLNRPRLKQVEKFKDNt |
| P30740 | T251 | Sugiyama | SERPINB1 ELANH2 MNEI PI2 | LLPDDIEDESTGLKKIEEQLtLEKLHEWTKPENLDFIEVNV |
| P31153 | S38 | Sugiyama | MAT2A AMS2 MATA2 | FLFTSESVGEGHPDKICDQIsDAVLDAHLQQDPDAKVACET |
| P31327 | S564 | Sugiyama | CPS1 | TEDRQLFSDKLNEINEKIAPsFAVEsIEDALKAADTIGyPV |
| P31327 | S569 | Sugiyama | CPS1 | LFSDKLNEINEKIAPsFAVEsIEDALKAADTIGyPVMIRSA |
| P31327 | S835 | Sugiyama | CPS1 | MCHPsIEGFTPRLPMNKEWPsNLDLRKELSEPSsTRIyAIA |
| P31327 | S898 | Sugiyama | CPS1 | LYKMRDILNMEKTLKGLNsEsMtEEtLKRAKEIGFSDKQIS |
| P31943 | S63 | Sugiyama | HNRNPH1 HNRPH HNRPH1 | IRFIYTREGRPsGEAFVELEsEDEVKLALKKDRETMGHRyV |
| P31946 | S39 | Sugiyama | YWHAB | ERyDDMAAAMKAVtEQGHELsNEERNLLsVAyKNVVGARRS |
| P31946 | T207 | Sugiyama | YWHAB | PEKACSLAKTAFDEAIAELDtLNEEsyKDstLIMQLLRDNL |
| P31947 | S37 | Sugiyama | SFN HME1 | ERyEDMAAFMKGAVEKGEELsCEERNLLsVAyKNVVGGQRA |
| P31947 | S69 | Sugiyama | SFN HME1 | KNVVGGQRAAWRVLSsIEQKsNEEGsEEKGPEVREYREKVE |
| P31947 | T197 | Sugiyama | SFN HME1 | SVFHYEIANsPEEAISLAKTtFDEAMADLHtLsEDsyKDst |
| P31947 | T207 | Sugiyama | SFN HME1 | PEEAISLAKTtFDEAMADLHtLsEDsyKDstLIMQLLRDNL |
| P31948 | S459 | Sugiyama | STIP1 | EAMKDytKAMDVYQKALDLDssCKEAADGYQRCMMAQyNRH |
| P31948 | S460 | Sugiyama | STIP1 | AMKDytKAMDVYQKALDLDssCKEAADGYQRCMMAQyNRHD |
| P34931 | T228 | Sugiyama | HSPA1L | DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK |
| P34932 | S414 | Sugiyama | HSPA4 APG2 HSPH2 | ITDVVPYPISLRWNsPAEEGssDCEVFSKNHAAPFSKVLTF |
| P35221 | S690 | Sugiyama | CTNNA1 | RAIMAQLPQEQKAKIAEQVAsFQEEKSKLDAEVSKWDDSGN |
| P35579 | S1892 | Sugiyama | MYH9 | LKQLKRQLEEAEEEAQRANAsRRKLQRELEDAtEtADAMNR |
| P35579 | S1943 | Sugiyama | MYH9 | RGDLPFVVPRRMARKGAGDGsDEEVDGKADGAEAKPAE___ |
| P35579 | T1151 | Sugiyama | MYH9 | EKQKRDLGEELEALKtELEDtLDstAAQQELRSKREQEVNI |
| P35659 | S231 | Sugiyama | DEK | SGMARKAKRTKCPEILsDEsssDEDEKKNKEEssDDEDKEs |
| P35659 | S303 | Sugiyama | DEK | KKADSSTTKKNQNSSKKEsEsEDssDDEPLIKKLKKPPTDE |
| P37802 | S163 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG |
| P37802 | S185 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______ |
| P37802 | T190 | Sugiyama | TAGLN2 KIAA0120 CDABP0035 | GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________ |
| P37840 | S129 | SIGNOR|EPSD|PSP | SNCA NACP PARK1 | QEGILEDMPVDPDNEAyEMPsEEGyQDyEPEA_________ |
| P38646 | T116 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD |
| P38646 | T120 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV |
| P38646 | Y118 | Sugiyama | HSPA9 GRP75 HSPA9B mt-HSP70 | ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK |
| P40855 | S147 | Sugiyama | PEX19 HK33 PXF OK/SW-cl.22 | SCLKETLSGLAKNATDLQNssMsEEELTKAMEGLGMDEGDG |
| P40925 | S326 | Sugiyama | MDH1 MDHA | NDFSREKMDLTAKELtEEKEsAFEFLssA____________ |
| P40925 | T321 | Sugiyama | MDH1 MDHA | EGLPINDFSREKMDLTAKELtEEKEsAFEFLssA_______ |
| P41091 | T468 | Sugiyama | EIF2S3 EIF2G | EKHWRLIGWGQIRRGVtIKPtVDDD________________ |
| P41236 | S121 | Sugiyama | PPP1R2 IPP2 | ARKLAAAEGLEPKyRIQEQEssGEEDsDLsPEEREKKRQFE |
| P42677 | S78 | Sugiyama | RPS27 MPS1 | GCSTVLCQPTGGKARLtEGCsFRRKQH______________ |
| P43034 | S152 | Sugiyama | PAFAH1B1 LIS1 MDCR MDS PAFAHA | IKVWDyEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADM |
| P43034 | S157 | Sugiyama | PAFAH1B1 LIS1 MDCR MDS PAFAHA | yEtGDFERtLKGHtDsVQDIsFDHsGKLLASCSADMTIKLW |
| P43243 | S234 | Sugiyama | MATR3 KIAA0723 | yDRMDyEDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMG |
| P43243 | S240 | Sugiyama | MATR3 KIAA0723 | EDDRLRDGERCRDDsFFGEtsHNyHKFDsEyERMGRGPGPL |
| P46776 | S68 | Sugiyama | RPL27A | yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV |
| P48444 | S138 | Sugiyama | ARCN1 COPD | ALGYRENVNLAQIRTFTEMDsHEEKVFRAVRETQEREAKAE |
| P48643 | T269 | Sugiyama | CCT5 CCTE KIAA0098 | AILTCPFEPPKPKTKHKLDVtsVEDyKALQKYEKEKFEEMI |
| P48741 | T228 | Sugiyama | HSPA7 HSP70B | DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR |
| P49321 | S176 | Sugiyama | NASP | EAKKTEDKSLAKPEtDKEQDsEMEKGGREDMDIsKsAEEPQ |
| P49321 | S497 | Sugiyama | NASP | tEGsEEDDKENDKtEEMPNDsVLENKsLQENEEEEIGNLEL |
| P49321 | T202 | Sugiyama | NASP | GREDMDIsKsAEEPQEKVDLtLDWLtEtsEEAKGGAAPEGP |
| P49321 | T207 | Sugiyama | NASP | DIsKsAEEPQEKVDLtLDWLtEtsEEAKGGAAPEGPNEAEV |
| P49327 | T2215 | Sugiyama | FASN FAS | DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN |
| P49591 | S394 | Sugiyama | SARS1 SARS SERS | SKKLDLEAWFPGSGAFRELVsCSNCTDyQARRLRIRYGQTK |
| P49736 | S139 | Sugiyama | MCM2 BM28 CCNL1 CDCL1 KIAA0030 | QRDREAGRGLGRMRRGLLyDsDEEDEERPARKRRQVERAtE |
| P49792 | T2027 | Sugiyama | RANBP2 NUP358 | DsDDIHFEPVVQMPEKVELVtGEEDEKVLYSQRVKLFRFDA |
| P49792 | T2703 | Sugiyama | RANBP2 NUP358 | KLNGKLYLDGsEKCRPLEENtADNEKECIIVWEKKPTVEEK |
| P50395 | T413 | Sugiyama | GDI2 RABGDIB | GtEsQIFIsRTyDAttHFEttCDDIKNIYKRMtGsEFDFEE |
| P50416 | T370 | Sugiyama | CPT1A CPT1 | DGRLLKPREMEQQMQRILDNtsEPQPGEARLAALTAGDRVP |
| P50502 | S75 | Sugiyama | ST13 AAG2 FAM10A1 HIP SNC6 | TKEEKPDSKKVEEDLKADEPssEEsDLEIDKEGVIEPDTDA |
| P50502 | S79 | Sugiyama | ST13 AAG2 FAM10A1 HIP SNC6 | KPDSKKVEEDLKADEPssEEsDLEIDKEGVIEPDTDAPQEM |
| P52597 | S63 | Sugiyama | HNRNPF HNRPF | VHFIYTREGRQsGEAFVELGsEDDVKMALKKDRESMGHRyI |
| P53396 | S455 | Sugiyama | ACLY | ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP |
| P53999 | S9 | Sugiyama | SUB1 PC4 RPO2TC1 | ____________MPKSKELVsssssGsDsDsEVDKKLKRKK |
| P54578 | S492 | Sugiyama | USP14 TGT | WHIAYVLLYGPRRVEIMEEEsEQ__________________ |
| P54652 | T229 | Sugiyama | HSPA2 | DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK |
| P55060 | S366 | Sugiyama | CSE1L CAS XPO2 | KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA |
| P55072 | S37 | Sugiyama | VCP HEL-220 HEL-S-70 | LKQKNRPNRLIVDEAINEDNsVVsLSQPKMDELQLFRGDTV |
| P55957 | S76 | Sugiyama | BID | ELQtDGNRssHsRLGRIEADsEsQEDIIRNIARHLAQVGDs |
| P57721 | S82 | Sugiyama | PCBP3 PCBP3-OT1 PCBP3OT | GKKGETVKKMREESGARINIsEGNCPERIVTITGPTDAIFK |
| P60174 | T217 | Sugiyama | TPI1 TPI | VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL |
| P60484 | S370 | GPS6|SIGNOR|EPSD|PSP | PTEN MMAC1 TEP1 | TVEEPSNPEASSsTSVtPDVsDNEPDHyRYsDttDsDPENE |
| P60484 | T366 | GPS6|SIGNOR|EPSD|PSP | PTEN MMAC1 TEP1 | YFTKTVEEPSNPEASSsTSVtPDVsDNEPDHyRYsDttDsD |
| P60709 | S199 | Sugiyama | ACTB | DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV |
| P60709 | S239 | Sugiyama | ACTB | VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE |
| P60709 | S323 | Sugiyama | ACTB | ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG |
| P60709 | S365 | Sugiyama | ACTB | ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________ |
| P60709 | S368 | Sugiyama | ACTB | sLstFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P60709 | S52 | Sugiyama | ACTB | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P60709 | S60 | Sugiyama | ACTB | HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD |
| P60709 | T201 | Sugiyama | ACTB | AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL |
| P60709 | T203 | Sugiyama | ACTB | RDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALDF |
| P60709 | T318 | Sugiyama | ACTB | VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs |
| P60709 | Y240 | Sugiyama | ACTB | ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA |
| P60709 | Y53 | Sugiyama | ACTB | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH |
| P60900 | S177 | Sugiyama | PSMA6 PROS27 | AGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTVET |
| P61247 | S237 | Sugiyama | RPS3A FTE1 MFTL | MLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyE |
| P61978 | S75 | Sugiyama | HNRNPK HNRPK | GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE |
| P61978 | S77 | Sugiyama | HNRNPK HNRPK | VIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIETI |
| P61981 | S38 | Sugiyama | YWHAG | ERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKNVVGARRS |
| P61981 | T210 | Sugiyama | YWHAG | PEQACHLAKtAFDDAIAELDtLNEDsyKDstLIMQLLRDNL |
| P61981 | T31 | Sugiyama | YWHAG | ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN |
| P62258 | S148 | Sugiyama | YWHAE | YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP |
| P62258 | T208 | EPSD|PSP|Sugiyama | YWHAE | PDRACRLAKAAFDDAIAELDtLsEEsyKDstLIMQLLRDNL |
| P62258 | T229 | Sugiyama | YWHAE | LsEEsyKDstLIMQLLRDNLtLWtsDMQGDGEEQNKEALQD |
| P62263 | T133 | Sugiyama | RPS14 PRO2640 | QsALRALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL__ |
| P62277 | S12 | Sugiyama | RPS13 | _________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD |
| P62277 | S14 | Sugiyama | RPS13 | _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK |
| P62736 | S241 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE |
| P62736 | S325 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG |
| P62736 | S54 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P62736 | S62 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P62736 | T320 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS |
| P62736 | Y242 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET |
| P62736 | Y55 | Sugiyama | ACTA2 ACTSA ACTVS GIG46 | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P62753 | S148 | Sugiyama | RPS6 OK/SW-cl.2 | tVPRRLGPKRASRIRKLFNLsKEDDVRQyVVRKPLNKEGKK |
| P62942 | T7 | Sugiyama | FKBP1A FKBP1 FKBP12 | ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy |
| P62979 | S123 | Sugiyama | RPS27A UBA80 UBCEP1 | LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK |
| P63104 | S28 | Sugiyama | YWHAZ | QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy |
| P63104 | T205 | Sugiyama | YWHAZ | PEKACSLAKtAFDEAIAELDtLsEEsyKDstLIMQLLRDNL |
| P63167 | S21 | Sugiyama | DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 | MCDRKAVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAH |
| P63167 | T26 | Sugiyama | DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 | AVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAHIKKEF |
| P63220 | S68 | Sugiyama | RPS21 | GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____ |
| P63261 | S199 | Sugiyama | ACTG1 ACTG | DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV |
| P63261 | S239 | Sugiyama | ACTG1 ACTG | VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE |
| P63261 | S323 | Sugiyama | ACTG1 ACTG | ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG |
| P63261 | S365 | Sugiyama | ACTG1 ACTG | ILAsLstFQQMWISKQEyDEsGPsIVHRKCF__________ |
| P63261 | S368 | Sugiyama | ACTG1 ACTG | sLstFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| P63261 | S52 | Sugiyama | ACTG1 ACTG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE |
| P63261 | S60 | Sugiyama | ACTG1 ACTG | HQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEHGIVTNWD |
| P63261 | T201 | Sugiyama | ACTG1 ACTG | AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL |
| P63261 | T203 | Sugiyama | ACTG1 ACTG | RDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALDF |
| P63261 | T318 | Sugiyama | ACTG1 ACTG | VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs |
| P63261 | Y240 | Sugiyama | ACTG1 ACTG | ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA |
| P63261 | Y53 | Sugiyama | ACTG1 ACTG | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIEH |
| P63267 | S240 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE |
| P63267 | S324 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG |
| P63267 | S53 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P63267 | S61 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P63267 | T319 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS |
| P63267 | Y241 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET |
| P63267 | Y54 | Sugiyama | ACTG2 ACTA3 ACTL3 ACTSG | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P67809 | S314 | Sugiyama | YBX1 NSEP1 YB1 | NPKPQDGKETKAADPPAENssAPEAEQGGAE__________ |
| P68032 | S241 | Sugiyama | ACTC1 ACTC | VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE |
| P68032 | S325 | Sugiyama | ACTC1 ACTC | tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG |
| P68032 | S54 | Sugiyama | ACTC1 ACTC | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68032 | S62 | Sugiyama | ACTC1 ACTC | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P68032 | T320 | Sugiyama | ACTC1 ACTC | VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS |
| P68032 | Y242 | Sugiyama | ACTC1 ACTC | ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET |
| P68032 | Y55 | Sugiyama | ACTC1 ACTC | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P68133 | S241 | Sugiyama | ACTA1 ACTA | VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE |
| P68133 | S325 | Sugiyama | ACTA1 ACTA | TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG |
| P68133 | S54 | Sugiyama | ACTA1 ACTA | PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE |
| P68133 | S62 | Sugiyama | ACTA1 ACTA | HQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEHGIItNWD |
| P68133 | T320 | Sugiyama | ACTA1 ACTA | VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS |
| P68133 | Y242 | Sugiyama | ACTA1 ACTA | ALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPET |
| P68133 | Y55 | Sugiyama | ACTA1 ACTA | sIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIEH |
| P68363 | S287 | Sugiyama | TUBA1B | FPLAtyAPVIsAEKAyHEQLsVAEItNACFEPANQMVKCDP |
| P68363 | S439 | Sugiyama | TUBA1B | SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________ |
| P68363 | S48 | Sugiyama | TUBA1B | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| P68363 | T292 | Sugiyama | TUBA1B | yAPVIsAEKAyHEQLsVAEItNACFEPANQMVKCDPRHGKy |
| P68363 | T51 | Sugiyama | TUBA1B | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| P68363 | T73 | Sugiyama | TUBA1B | FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI |
| P68363 | T80 | Sugiyama | TUBA1B | KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA |
| P68363 | T82 | Sugiyama | TUBA1B | VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN |
| P68363 | Y83 | Sugiyama | TUBA1B | PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy |
| P68366 | S287 | Sugiyama | TUBA4A TUBA1 | FPLAtyAPVIsAEKAyHEQLsVAEItNACFEPANQMVKCDP |
| P68366 | T292 | Sugiyama | TUBA4A TUBA1 | yAPVIsAEKAyHEQLsVAEItNACFEPANQMVKCDPRHGKy |
| P78371 | T474 | Sugiyama | CCT2 99D8.1 CCTB | AGYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAILGIT |
| P78371 | T475 | Sugiyama | CCT2 99D8.1 CCTB | GYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAILGITE |
| P80303 | S332 | Sugiyama | NUCB2 NEFA | LVTLEEFLKATEKKEFLEPDsWEtLDQQQFFtEEELKEyEN |
| P80303 | T335 | Sugiyama | NUCB2 NEFA | LEEFLKATEKKEFLEPDsWEtLDQQQFFtEEELKEyENIIA |
| P80303 | T343 | Sugiyama | NUCB2 NEFA | EKKEFLEPDsWEtLDQQQFFtEEELKEyENIIALQENELKK |
| P83731 | S38 | Sugiyama | RPL24 | GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK |
| P83731 | S7 | Sugiyama | RPL24 | ______________MKVELCsFsGyKIYPGHGRRYARTDGK |
| P84098 | T29 | Sugiyama | RPL19 | RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL |
| P98175 | S738 | Sugiyama | RBM10 DXS8237E GPATC9 GPATCH9 KIAA0122 | sDDRPsPPRGLVAAysGEsDsEEEQERGGPEREEKLTDWQK |
| Q00688 | T103 | Sugiyama | FKBP3 FKBP25 | EQVKNVKLNEDKPKEtKsEEtLDEGPPKYTKSVLKKGDKTN |
| Q01105 | S161 | Sugiyama | SET | FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK |
| Q01105 | S63 | Sugiyama | SET | EAIEHIDEVQNEIDRLNEQAsEEILKVEQKYNKLRQPFFQK |
| Q01518 | S338 | Sugiyama | CAP1 CAP | EPAVLELEGKKWRVENQENVsNLVIEDTELKQVAYIYKCVN |
| Q01581 | S83 | Sugiyama | HMGCS1 HMGCS | EDINSLCMTVVQNLMERNNLsyDCIGRLEVGTEtIIDKSKS |
| Q02790 | S263 | Sugiyama | FKBP4 FKBP52 | LKYELHLKSFEKAKEsWEMNsEEKLEQSTIVKERGtVYFKE |
| Q02790 | S350 | Sugiyama | FKBP4 FKBP52 | LKLQAFsAAIESCNKALELDsNNEKGLFRRGEAHLAVNDFE |
| Q04637 | S1246 | Sugiyama | EIF4G1 EIF4F EIF4G EIF4GI | ALPPVsPLKAALsEEELEKKsKAIIEEyLHLNDMKEAVQCV |
| Q07021 | S201 | Sugiyama | C1QBP GC1QBP HABP1 SF2P32 | ALVLDCHyPEDEVGQEDEAEsDIFsIREVsFQstGESEWKD |
| Q07021 | S210 | Sugiyama | C1QBP GC1QBP HABP1 SF2P32 | EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS |
| Q07817 | S49 | GPS6|SIGNOR|EPSD|PSP | BCL2L1 BCL2L BCLX | DVEENRTEAPEGTESEMEtPsAINGNPSWHLADsPAVNGAT |
| Q12849 | S202 | Sugiyama | GRSF1 | IHFLLNRDGKRRGDALIEMEsEQDVQKALEKHRMYMGQRYV |
| Q12906 | T300 | Sugiyama | ILF3 DRBF MPHOSPH4 NF90 | ASGIVMPDGSGIYDPCEKEAtDAIGHLDRQQREDItQsAQH |
| Q12952 | S174 | Sugiyama | FOXL1 FKHL11 FREAC7 | AKRPRAETHQRSAEAQPEAGsGAGGSGPAISRLQAAPAGPS |
| Q13371 | S19 | Sugiyama | PDCL PHLOP1 PhLP1 | __MTTLDDKLLGEKLQyyysssEDEDsDHEDKDRGRCAPAs |
| Q13409 | S101 | Sugiyama | DYNC1I2 DNCI2 DNCIC2 | WVPPPMsPSSKsVStPsEAGsQDsGDGAVGsRTLHWDTDPS |
| Q13409 | S97 | Sugiyama | DYNC1I2 DNCI2 DNCIC2 | FSEYWVPPPMsPSSKsVStPsEAGsQDsGDGAVGsRTLHWD |
| Q13435 | S289 | Sugiyama | SF3B2 SAP145 | IPQALEKILQLKESRQEEMNsQQEEEEMETDARssLGQsAs |
| Q13442 | S63 | Sugiyama | PDAP1 HASPP28 | GGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGLIDI |
| Q13509 | S75 | Sugiyama | TUBB3 TUBB4 | SSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIFGQS |
| Q13509 | T72 | Sugiyama | TUBB3 TUBB4 | NEASSHKYVPRAILVDLEPGtMDsVRSGAFGHLFRPDNFIF |
| Q13541 | S112 | Sugiyama | EIF4EBP1 | EAsQsHLRNsPEDKRAGGEEsQFEMDI______________ |
| Q13547 | S421 | Sugiyama | HDAC1 RPD3L1 | PDKRIsICssDKRIACEEEFsDsEEEGEGGRKNsSNFKKAK |
| Q13547 | S423 | Sugiyama | HDAC1 RPD3L1 | KRIsICssDKRIACEEEFsDsEEEGEGGRKNsSNFKKAKRV |
| Q13885 | S75 | Sugiyama | TUBB2A TUBB2 | AGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs |
| Q13885 | T72 | Sugiyama | TUBB2A TUBB2 | NEAAGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF |
| Q14152 | S907 | Sugiyama | EIF3A EIF3S10 KIAA0139 | DSRWGDRDsEGtWRKGPEADsEWRRGPPEKEWRRGEGRDED |
| Q14192 | S238 | Sugiyama | FHL2 DRAL SLIM3 | AKKCAGCTNPISGLGGtKyIsFEERQWHNDCFNCKKCsLsL |
| Q14203 | S417 | Sugiyama | DCTN1 | KKNQELEVVRQQRERLQEELsQAEstIDELKEQVDAALGAE |
| Q14203 | S421 | Sugiyama | DCTN1 | ELEVVRQQRERLQEELsQAEstIDELKEQVDAALGAEEMVE |
| Q14203 | T422 | Sugiyama | DCTN1 | LEVVRQQRERLQEELsQAEstIDELKEQVDAALGAEEMVEM |
| Q14257 | S146 | Sugiyama | RCN2 ERC55 | MyDRVIDFDENtALDDAEEEsFRKLHLKDKKRFEKANQDSG |
| Q14257 | S284 | Sugiyama | RCN2 ERC55 | AQEEALHLIDEMDLNGDKKLsEEEILENPDLFLtsEAtDyG |
| Q14257 | S298 | Sugiyama | RCN2 ERC55 | NGDKKLsEEEILENPDLFLtsEAtDyGRQLHDDyFyHDEL_ |
| Q14257 | T137 | Sugiyama | RCN2 ERC55 | VTWDEyNIQMyDRVIDFDENtALDDAEEEsFRKLHLKDKKR |
| Q14257 | T301 | Sugiyama | RCN2 ERC55 | KKLsEEEILENPDLFLtsEAtDyGRQLHDDyFyHDEL____ |
| Q14444 | T303 | Sugiyama | CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 | YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV |
| Q14444 | T306 | Sugiyama | CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 | QSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEVVNS |
| Q14498 | S337 | Sugiyama | RBM39 HCC1 RNPC2 | AGRPMKVGHVTERtDAssAssFLDsDELERtGIDLGtTGRL |
| Q14498 | S341 | Sugiyama | RBM39 HCC1 RNPC2 | MKVGHVTERtDAssAssFLDsDELERtGIDLGtTGRLQLMA |
| Q14498 | T347 | Sugiyama | RBM39 HCC1 RNPC2 | TERtDAssAssFLDsDELERtGIDLGtTGRLQLMARLAEGT |
| Q14566 | T321 | Sugiyama | MCM6 | CCVAPTNPRFGGKELRDEEQtAEsIKNQMTVKEWEKVFEMs |
| Q14568 | S50 | Sugiyama | HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 | MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL |
| Q14568 | S52 | Sugiyama | HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 | LIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDS |
| Q14568 | S53 | Sugiyama | HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 | IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG |
| Q14790 | T273 | SIGNOR|EPSD|PSP | CASP8 MCH5 | KLHSIRDRNGtHLDAGALTTtFEELHFEIKPHDDCTVEQIY |
| Q14978 | S637 | Sugiyama | NOLC1 KIAA0035 NS5ATP13 | GEKRAssPFRRVREEEIEVDsRVADNsFDAKRGAAGDWGER |
| Q14978 | S90 | Sugiyama | NOLC1 KIAA0035 NS5ATP13 | ANGPVAKKAKKKAsssDsEDssEEEEEVQGPPAKKAAVPAK |
| Q14C86 | S740 | Sugiyama | GAPVD1 GAPEX5 KIAA1521 RAP6 | LPSDSEAPDLKQEERLQELEsCsGLGstSDDTDVREVSSRP |
| Q15058 | S1292 | Sugiyama | KIF14 KIAA0042 | LKIYNGLFAISKAHEEQDEEsQDNLFSSDRAIQSLTIQTAC |
| Q15084 | S169 | Sugiyama | PDIA6 ERP5 P5 TXNDC7 | GKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFYAPW |
| Q15084 | S389 | Sugiyama | PDIA6 ERP5 P5 TXNDC7 | FALLKGsFsEQGINEFLRELsFGRGstAPVGGGAFPtIVER |
| Q15181 | S127 | Sugiyama | PPA1 IOPPP PP | NDKHTGCCGDNDPIDVCEIGsKVCARGEIIGVKVLGILAMI |
| Q15185 | S113 | Sugiyama | PTGES3 P23 TEBP | RAKLNWLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGD |
| Q15185 | S118 | Sugiyama | PTGES3 P23 TEBP | WLsVDFNNWKDWEDDsDEDMsNFDRFSEMMNNMGGDEDVDL |
| Q15185 | S72 | Sugiyama | PTGES3 P23 TEBP | EIDLFHCIDPNDsKHKRtDRsILCCLRKGEsGQsWPRLTKE |
| Q15293 | S69 | Sugiyama | RCN1 RCN | PPEDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVD |
| Q15293 | S80 | Sugiyama | RCN1 RCN | HEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGDGFVt |
| Q15293 | T100 | Sugiyama | RCN1 RCN | sKERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNV |
| Q15293 | T71 | Sugiyama | RCN1 RCN | EDNQsFQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRI |
| Q15293 | T76 | Sugiyama | RCN1 RCN | FQYDHEAFLGKEDsKtFDQLtPDEsKERLGKIVDRIDNDGD |
| Q15365 | S50 | Sugiyama | PCBP1 | GKKGESVKRIREEsGARINIsEGNCPERIItLTGPTNAIFK |
| Q15366 | S50 | Sugiyama | PCBP2 | GKKGESVKKMREESGARINIsEGNCPERIITLAGPTNAIFK |
| Q15427 | T14 | Sugiyama | SF3B4 SAP49 | _______MAAGPISERNQDAtVyVGGLDEKVSEPLLWELFL |
| Q16143 | S118 | SIGNOR|EPSD|PSP | SNCB | VAQEAAEEPLIEPLMEPEGEsYEDPPQEEyQEYEPEA____ |
| Q16181 | T426 | Sugiyama | SEPTIN7 CDC10 SEPT7 | DEKANWEAQQRILEQQNssRtLEKNKKKGKIF_________ |
| Q16576 | S163 | Sugiyama | RBBP7 RBAP46 | tPssDVLVFDyTKHPAKPDPsGECNPDLRLRGHQKEGYGLS |
| Q16576 | T10 | Sugiyama | RBBP7 RBAP46 | ___________MAsKEMFEDtVEERVINEEYKIWKKNTPFL |
| Q16595 | S89 | Sugiyama | FXN FRDA X25 | KKQSVYLMNLRKsGtLGHPGsLDEttyERLAEETLDSLAEF |
| Q16595 | T93 | Sugiyama | FXN FRDA X25 | VYLMNLRKsGtLGHPGsLDEttyERLAEETLDSLAEFFEDL |
| Q16595 | T94 | Sugiyama | FXN FRDA X25 | YLMNLRKsGtLGHPGsLDEttyERLAEETLDSLAEFFEDLA |
| Q16625 | S471 | EPSD|PSP | OCLN | DEINKELSRLDKELDDYREEsEEyMAAADEYNRLKQVKGsA |
| Q16637 | S31 | Sugiyama | SMN1 SMN SMNT; SMN2 SMNC | GVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDKAVAsFK |
| Q16637 | T37 | Sugiyama | SMN1 SMN SMNT; SMN2 SMNC | DsVLFRRGtGQsDDsDIWDDtALIKAYDKAVAsFKHALKNG |
| Q16665 | S576 | GPS6|SIGNOR|EPSD|PSP | HIF1A BHLHE78 MOP1 PASD8 | DLDLEMLAPYIPMDDDFQLRsFDQLSPLESSSAsPESASPQ |
| Q16665 | S657 | GPS6|SIGNOR|EPSD|PSP | HIF1A BHLHE78 MOP1 PASD8 | ILIAsPsPTHIHKETTSATSsPYRDTQSRTAsPNRAGKGVI |
| Q2VIR3 | T468 | Sugiyama | EIF2S3B | EKHWRLIGWGQIRRGVtIKPtVDDD________________ |
| Q4G0J3 | S337 | Sugiyama | LARP7 HDCMA18P | QKDIIKEASEASKENRDIEIstEEEKDtGDLKDssLLKTKR |
| Q562R1 | S240 | Sugiyama | ACTBL2 | VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE |
| Q562R1 | Y241 | Sugiyama | ACTBL2 | ALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPEA |
| Q56P03 | S55 | Sugiyama | EAPP C14orf11 BM-036 | HGTPDQKRKLIRECLTGESEsssEDEFEKEMEAELNSTMKT |
| Q58FF6 | T165 | Sugiyama | HSP90AB4P | DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG |
| Q58FF7 | S370 | Sugiyama | HSP90AB3P HSP90BC | KETQKSTYYITGESKEQVANsAFVERVRKQGFEVVYMTEPI |
| Q58FF7 | T169 | Sugiyama | HSP90AB3P HSP90BC | DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG |
| Q5H9R7 | S579 | Sugiyama | PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 | IDQFGFNDEKFADQDDIGNVsFDRVSDINFTLNTNESGNIA |
| Q5H9R7 | S617 | Sugiyama | PPP6R3 C11orf23 KIAA1558 PP6R3 SAPL SAPS3 | NIALFEACCKERIQQFDDGGsDEEDIWEEKHIAFtPEsQRR |
| Q5T035 | S66 | Sugiyama | FAM120A2P C9orf129 | LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERSLPI |
| Q6DD88 | S38 | Sugiyama | ATL3 | AMESSKPGPVQVVLVQKDQHsFELDEKALASILLQDHIRDL |
| Q6NVY1 | T368 | Sugiyama | HIBCH | AVLIDKDQSPKWKPADLKEVtEEDLNNHFKSLGsSDLKF__ |
| Q6PEY2 | S287 | Sugiyama | TUBA3E | FPLAtyAPVIsAEKAyHEQLsVAEItNACFEPANQMVKCDP |
| Q6PEY2 | S48 | Sugiyama | TUBA3E | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q6PEY2 | T292 | Sugiyama | TUBA3E | yAPVIsAEKAyHEQLsVAEItNACFEPANQMVKCDPRHGKY |
| Q6PEY2 | T51 | Sugiyama | TUBA3E | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| Q6S8J3 | S1065 | Sugiyama | POTEE A26C1A POTE2 | ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________ |
| Q6S8J3 | S1068 | Sugiyama | POTEE A26C1A POTE2 | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| Q6S8J3 | S939 | Sugiyama | POTEE A26C1A POTE2 | VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE |
| Q6S8J3 | Y940 | Sugiyama | POTEE A26C1A POTE2 | ALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPEA |
| Q6UX04 | S203 | Sugiyama | CWC27 SDCCAG10 UNQ438/PRO871 | KKEKPEEEVKKLKPKGTKNFsLLsFGEEAEEEEEEVNRVSQ |
| Q6UX04 | S206 | Sugiyama | CWC27 SDCCAG10 UNQ438/PRO871 | KPEEEVKKLKPKGTKNFsLLsFGEEAEEEEEEVNRVSQSMK |
| Q6UXH1 | S295 | Sugiyama | CRELD2 UNQ185/PRO211 | KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY |
| Q6ZMR3 | S161 | Sugiyama | LDHAL6A LDHL2 | DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH |
| Q71U36 | S287 | Sugiyama | TUBA1A TUBA3 | FPLAtyAPVIsAEKAyHEQLsVAEItNACFEPANQMVKCDP |
| Q71U36 | S439 | Sugiyama | TUBA1A TUBA3 | SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________ |
| Q71U36 | S48 | Sugiyama | TUBA1A TUBA3 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q71U36 | T292 | Sugiyama | TUBA1A TUBA3 | yAPVIsAEKAyHEQLsVAEItNACFEPANQMVKCDPRHGKy |
| Q71U36 | T51 | Sugiyama | TUBA1A TUBA3 | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| Q71U36 | T73 | Sugiyama | TUBA1A TUBA3 | FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI |
| Q71U36 | T80 | Sugiyama | TUBA1A TUBA3 | KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA |
| Q71U36 | T82 | Sugiyama | TUBA1A TUBA3 | VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN |
| Q71U36 | Y83 | Sugiyama | TUBA1A TUBA3 | PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy |
| Q71UM5 | S78 | Sugiyama | RPS27L | GCSTVLCQPTGGKARLtEGCsFRRKQH______________ |
| Q86UE4 | S457 | Sugiyama | MTDH AEG1 LYRIC | LPTGKSKKKKKKKKKQGEDNstAQDtEELEKEIREDLPVNt |
| Q86V81 | S239 | Sugiyama | ALYREF ALY BEF THOC4 | tRGGARGRGRGAGRNSKQQLsAEELDAQLDAyNARMDts__ |
| Q86WR0 | S204 | Sugiyama | CCDC25 | RSYssLMKVENMSSNQDGNDsDEFM________________ |
| Q8IW35 | S752 | Sugiyama | CEP97 LRRIQ2 | IMGNSIDTVRYGKESDLGDVsEEHGEWNKEssNNEQDNsLL |
| Q8NBS9 | S255 | Sugiyama | TXNDC5 TLP46 UNQ364/PRO700 | EHSETVKIGKVDCtQHyELCsGNQVRGyPtLLWFRDGKKVD |
| Q8NE71 | S595 | Sugiyama | ABCF1 ABC50 | TKEALTRKQQKCRRKNQDEEsQEAPELLKRPKEYTVRFTFP |
| Q8NFH4 | S142 | Sugiyama | NUP37 | GHTDFINGLVFDPKEGQEIAsVSDDHTCRIWNLEGVQTAHF |
| Q8NHW5 | S304 | Sugiyama | RPLP0P6 | DTTAAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD_______ |
| Q8NHW5 | S307 | Sugiyama | RPLP0P6 | AAPAAAAAPAKVEAKEEsEEsDEDMGFGLFD__________ |
| Q8TAM6 | S280 | Sugiyama | ERMN KIAA1189 | TISYRKIRKGNTKQRIDEFEsMMHL________________ |
| Q8TBB5 | S418 | Sugiyama | KLHDC4 | IKQVLtAPGsAGQPRsEDEDsLEEAGsPAPGPCPRSNAMLA |
| Q92598 | S509 | Sugiyama | HSPH1 HSP105 HSP110 KIAA0201 | IFTISTASMVEKVPtEENEMssEADMECLNQRPPENPDTDK |
| Q92769 | S422 | Sugiyama | HDAC2 | PDKRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGA |
| Q92769 | S424 | Sugiyama | HDAC2 | KRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGAKK |
| Q92878 | S623 | Sugiyama | RAD50 | SSEQNKNHINNELKRKEEQLsSyEDKLFDVCGsQDFESDLD |
| Q92878 | Y625 | Sugiyama | RAD50 | EQNKNHINNELKRKEEQLsSyEDKLFDVCGsQDFESDLDRL |
| Q92900 | S274 | Sugiyama | UPF1 KIAA0221 RENT1 | ARQITAQQINKLEELWKENPsAtLEDLEKPGVDEEPQHVLL |
| Q92900 | T276 | Sugiyama | UPF1 KIAA0221 RENT1 | QITAQQINKLEELWKENPsAtLEDLEKPGVDEEPQHVLLRy |
| Q92973 | S339 | Sugiyama | TNPO1 KPNB2 MIP1 TRN | SDIDIILLKGDVEEDEtIPDsEQDIRPRFHRSRTVAQQHDE |
| Q92973 | T335 | Sugiyama | TNPO1 KPNB2 MIP1 TRN | GMKySDIDIILLKGDVEEDEtIPDsEQDIRPRFHRSRTVAQ |
| Q96D15 | S76 | Sugiyama | RCN3 UNQ239/PRO272 | HEAFLGREVAKEFDQLtPEEsQARLGRIVDRMDRAGDGDGW |
| Q96D15 | T208 | Sugiyama | RCN3 UNQ239/PRO272 | LTAFLHPEEFPHMRDIVIAEtLEDLDRNKDGYVQVEEYIAD |
| Q96D15 | T72 | Sugiyama | RCN3 UNQ239/PRO272 | FQYDHEAFLGREVAKEFDQLtPEEsQARLGRIVDRMDRAGD |
| Q96D46 | T470 | Sugiyama | NMD3 CGI-07 | EAIRKNVNIyRDsAIPVEsDtDDEGAPRISLAEMLEDLHIs |
| Q96HE7 | S143 | Sugiyama | ERO1A ERO1L UNQ434/PRO865 | EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD |
| Q96K76 | S917 | Sugiyama | USP47 | sKstEtsDFENIEsPLNERDsSAsVDNRELEQHIQtsDPEN |
| Q96K76 | S920 | Sugiyama | USP47 | tEtsDFENIEsPLNERDsSAsVDNRELEQHIQtsDPENFQs |
| Q96P70 | S890 | Sugiyama | IPO9 IMP9 KIAA1192 RANBP9 HSPC273 | GINADDKRLQDIRVKGEEIysMDEGIRTRSKSAKNPERWTN |
| Q96RL1 | S101 | Sugiyama | UIMC1 RAP80 RXRIP110 | EEEQFALALKMSEQEAREVNsQEEEEEELLRKAIAESLNSC |
| Q96SB4 | S334 | Sugiyama | SRPK1 | ERPLKENPPNKMtQEKLEEsstIGQDQtLMERDTEGGAAEI |
| Q96SB4 | T341 | Sugiyama | SRPK1 | PPNKMtQEKLEEsstIGQDQtLMERDTEGGAAEINCNGVIE |
| Q99523 | S825 | Sugiyama | SORT1 | DGVDALDtAsHtNKsGYHDDsDEDLLE______________ |
| Q99733 | S121 | Sugiyama | NAP1L4 NAP2 | PLFDKRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKV |
| Q99733 | S22 | Sugiyama | NAP1L4 NAP2 | ADHsFsDGVPsDsVEAAKNAsNtEKLtDQVMQNPRVLAALQ |
| Q99733 | T28 | Sugiyama | NAP1L4 NAP2 | DGVPsDsVEAAKNAsNtEKLtDQVMQNPRVLAALQERLDNV |
| Q99816 | S299 | Sugiyama | TSG101 | QEVAEVDKNIELLKKKDEELssALEKMENQsENNDIDEVII |
| Q99816 | S300 | Sugiyama | TSG101 | EVAEVDKNIELLKKKDEELssALEKMENQsENNDIDEVIIP |
| Q99832 | T351 | Sugiyama | CCT7 CCTH NIP7-1 | QtSVNALSADVLGRCQVFEEtQIGGERyNFFtGCPKAKTCt |
| Q99986 | S342 | GPS6|SIGNOR|iPTMNet|EPSD|PSP | VRK1 | DILLQGLKAIGSKDDGKLDLsVVENGGLKAKTItKKRKKEI |
| Q9BPX3 | S674 | Sugiyama | NCAPG CAPG NYMEL3 | IEPFKTKKIKTLHCEGtEINsDDEQEsKEVEETATAKNVLK |
| Q9BQE3 | S439 | Sugiyama | TUBA1C TUBA6 | SEAREDMAALEKDyEEVGADsADGEDEGEEy__________ |
| Q9BQE3 | S48 | Sugiyama | TUBA1C TUBA6 | HGIQPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFV |
| Q9BQE3 | T51 | Sugiyama | TUBA1C TUBA6 | QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE |
| Q9BQE3 | T73 | Sugiyama | TUBA1C TUBA6 | FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI |
| Q9BQE3 | T80 | Sugiyama | TUBA1C TUBA6 | KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA |
| Q9BQE3 | T82 | Sugiyama | TUBA1C TUBA6 | VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN |
| Q9BQE3 | Y83 | Sugiyama | TUBA1C TUBA6 | PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy |
| Q9BRS2 | S21 | Sugiyama | RIOK1 RIO1 | MDYRRLLMSRVVPGQFDDADssDsENRDLKTVKEKDDILFE |
| Q9BUL5 | S315 | Sugiyama | PHF23 | PADSESKEVGsTETSQDGDAsssEGEMRVMDEDIMVESGDD |
| Q9BUL5 | S317 | Sugiyama | PHF23 | DSESKEVGsTETSQDGDAsssEGEMRVMDEDIMVESGDDSW |
| Q9BVA1 | S75 | Sugiyama | TUBB2B | tGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVFGQs |
| Q9BVA1 | T72 | Sugiyama | TUBB2B | NEAtGNKYVPRAILVDLEPGtMDsVRsGPFGQIFRPDNFVF |
| Q9BXJ9 | S855 | Sugiyama | NAA15 GA19 NARG1 NATH TBDN100 | ALAFMPPGYEEDMKItVNGDssAEAEELANEI_________ |
| Q9BYX7 | S239 | Sugiyama | POTEKP ACTBL3 FKSG30 | VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE |
| Q9BYX7 | S365 | Sugiyama | POTEKP ACTBL3 FKSG30 | ILASLSTFQQMWISKQEyDEsGPsIVHRKCF__________ |
| Q9BYX7 | S368 | Sugiyama | POTEKP ACTBL3 FKSG30 | SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________ |
| Q9BYX7 | Y240 | Sugiyama | POTEKP ACTBL3 FKSG30 | ALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPEA |
| Q9C0C2 | S1046 | Sugiyama | TNKS1BP1 KIAA1741 TAB182 | GLFsPstAHVPDGALGQRDQssWQNsDAsQEVGGHQERQQA |
| Q9C0C2 | S1174 | Sugiyama | TNKS1BP1 KIAA1741 TAB182 | ttAGsVDWTDQLGLRNLEVssCVGsGGssEAREsAVGQMGW |
| Q9C0C2 | S806 | Sugiyama | TNKS1BP1 KIAA1741 TAB182 | STREWASRCGIGQEEMEAsSsQDQSKVSAPGVLTAQDRVVG |
| Q9C0C2 | T1323 | Sugiyama | TNKS1BP1 KIAA1741 TAB182 | ELGVGQMDWGNNLGLRDLEVtCDPDsGGsQGLRGCGVGQMD |
| Q9H3N1 | S247 | Sugiyama | TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268 | EsAQPLKKVEEEQEADEEDVsEEEAEsKEGtNKDFPQNAIR |
| Q9H4B4 | S304 | Sugiyama | PLK3 CNK FNK PRK | SLPARQLLAAILRASPRDRPsIDQILRHDFFTKGYTPDRLP |
| Q9H4B4 | S86 | Sugiyama | PLK3 CNK FNK PRK | RLLGKGGFARCYEAtDtETGsAYAVKVIPQSRVAKPHQREK |
| Q9H4B4 | T156 | Sugiyama | PLK3 CNK FNK PRK | YIFLELCSRKSLAHIWKARHtLLEPEVRYYLRQILSGLKYL |
| Q9H4B4 | T80 | Sugiyama | PLK3 CNK FNK PRK | RTYLKGRLLGKGGFARCYEAtDtETGsAYAVKVIPQSRVAK |
| Q9H4B4 | T82 | Sugiyama | PLK3 CNK FNK PRK | YLKGRLLGKGGFARCYEAtDtETGsAYAVKVIPQSRVAKPH |
| Q9H5H4 | S111 | Sugiyama | ZNF768 | PGLVPPsPEFAPRsPEsDSQsPEFEsQSPRyEPQsPGYEPR |
| Q9H788 | S159 | Sugiyama | SH2D4A PPP1R38 SH2A | NQQtKDIWKKVAEKEELEQGsRPAPTLEEEKIRSLSSSSRN |
| Q9H814 | S226 | Sugiyama | PHAX RNUXA | RLGNRPEMNYKGRYEITAEDsQEKVADEISFRLQEPKKDLI |
| Q9HCC0 | S256 | Sugiyama | MCCC2 MCCB | QGTIFLAGPPLVKAATGEEVsAEDLGGADLHCRKSGVSDHW |
| Q9HCN4 | S338 | Sugiyama | GPN1 MBDIN RPAP4 XAB1 HUSSY-23 | HPsDLILtRGTLDEEDEEADsDtDDIDHRVTEESHEEPAFQ |
| Q9NPF0 | S81 | Sugiyama | CD320 8D6A UNQ198/PRO224 | CRtSGLCVPLTWRCDRDLDCsDGsDEEECRIEPCTQKGQCP |
| Q9NR30 | S121 | Sugiyama | DDX21 | PIEKKVVSSKTKKVTKNEEPsEEEIDAPKPKKMKKEKEMNG |
| Q9NR50 | S260 | Sugiyama | EIF2B3 | ASSQQGQEEKEEDLKKKELKsLDIYsFIKEANTLNLAPYDA |
| Q9NR50 | S265 | Sugiyama | EIF2B3 | GQEEKEEDLKKKELKsLDIYsFIKEANTLNLAPYDACWNAC |
| Q9NRF8 | S574 | Sugiyama | CTPS2 | YLQQGCKLsssDRysDAsDDsFSEPRIAELEIS________ |
| Q9NUQ3 | S105 | Sugiyama | TXLNG CXorf15 ELRG LSR5 | GsDFItENRNLVsPAyCtQEsREEIPGGEARTDPPDGQQDS |
| Q9NUQ3 | Y100 | Sugiyama | TXLNG CXorf15 ELRG LSR5 | LEEDEGsDFItENRNLVsPAyCtQEsREEIPGGEARTDPPD |
| Q9NVR5 | S773 | Sugiyama | DNAAF2 C14orf104 KTU | EFIKEKSATCSNEEKDNLNEsVITEEKETDGDHLsSLLNKT |
| Q9NYF8 | S397 | Sugiyama | BCLAF1 BTF KIAA0164 | DQEALDyFsDKEsGKQKFNDsEGDDtEEtEDyRQFRKsVLA |
| Q9NYL9 | S25 | Sugiyama | TMOD3 | FRKDLEKyKDLDEDELLGNLsEtELKQLETVLDDLDPENAL |
| Q9NZB2 | S417 | Sugiyama | FAM120A C9orf10 KIAA0183 OSSA | LSEPAPLTLDTSGKNLtEQNsysNIPHEGKHtPLyERssPI |
| Q9UHD8 | S482 | Sugiyama | SEPTIN9 KIAA0991 MSF SEPT9 | TADLLSNGIDVYPQKEFDEDsEDRLVNEKFREMIPFAVVGS |
| Q9UHI6 | S677 | Sugiyama | DDX20 DP103 GEMIN3 | DSySSRTSSQSKGNKsyLEGssDNQLKDsEstPVDDRIsLE |
| Q9UHI6 | S678 | Sugiyama | DDX20 DP103 GEMIN3 | SySSRTSSQSKGNKsyLEGssDNQLKDsEstPVDDRIsLEQ |
| Q9UI15 | S185 | Sugiyama | TAGLN3 NP25 | EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______ |
| Q9UI15 | T190 | Sugiyama | TAGLN3 NP25 | GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________ |
| Q9UIQ6 | S72 | Sugiyama | LNPEP OTASE | RLLVRGLGEHEMEEDEEDyEssAKLLGMsFMNRssGLRNsA |
| Q9UPN3 | T1097 | Sugiyama | MACF1 ABP620 ACF7 KIAA0465 KIAA0754 KIAA1251 | SRTDRDAWQDNALRIAEQEHtQEDLQQLRsDLDAVsMKCDS |
| Q9UPQ0 | S201 | Sugiyama | LIMCH1 KIAA1102 | DCWDsERsDsLsPPRHGRDDsFDsLDsFGsRsRQtPsPDVV |
| Q9UQ80 | T386 | Sugiyama | PA2G4 EBP1 | tQKKKKKKAsKtAENAtsGEtLEENEAGD____________ |
| Q9Y266 | S136 | Sugiyama | NUDC | QLEIDQKKDAENHEAQLKNGsLDsPGKQDtEEDEEEDEKDK |
| Q9Y266 | T145 | Sugiyama | NUDC | AENHEAQLKNGsLDsPGKQDtEEDEEEDEKDKGKLKPNLGN |
| Q9Y2B0 | S178 | Sugiyama | CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 | NVKDKLCSKRtDLCDHALHIsHDEL________________ |
| Q9Y2X7 | S385 | Sugiyama | GIT1 | DNLELsLRSQSDLDDQHDyDsVAsDEDtDQEPLRSTGATRS |
| Q9Y3B9 | S67 | Sugiyama | RRP15 KIAA0507 CGI-115 | GSCGsEKDHFYsDDDAIEADsEGDAEPCDKENENDGEssVG |
| Q9Y3F4 | S254 | Sugiyama | STRAP MAWD UNRIP | EKEFLVAGGEDFKLyKyDyNsGEELEsyKGHFGPIHCVRFS |
| Q9Y3F4 | S260 | Sugiyama | STRAP MAWD UNRIP | AGGEDFKLyKyDyNsGEELEsyKGHFGPIHCVRFSPDGELy |
| Q9Y3F4 | S312 | Sugiyama | STRAP MAWD UNRIP | WQTVVGKtyGLWKCVLPEEDsGELAKPKIGFPETTEEELEE |
| Q9Y4L1 | S742 | Sugiyama | HYOU1 GRP170 HSPH4 ORP150 | KLQDLTLRDLEKQEREKAANsLEAFIFEtQDKLyQPEyQEV |
| Q9Y4L1 | T750 | Sugiyama | HYOU1 GRP170 HSPH4 ORP150 | DLEKQEREKAANsLEAFIFEtQDKLyQPEyQEVsTEEQREE |
| Q9Y5S9 | S56 | Sugiyama | RBM8A RBM8 HSPC114 MDS014 | KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF |
| Q9Y696 | S167 | Sugiyama | CLIC4 | TLQKLDEYLNSPLPDEIDENsMEDIKFSTRKFLDGNEMTLA |
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| Cell Cycle | R-HSA-1640170 | 1.665335e-15 | 14.778 | 0 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 5.486722e-13 | 12.261 | 0 | 0 |
| M Phase | R-HSA-68886 | 1.871969e-11 | 10.728 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 4.958814e-10 | 9.305 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 7.228903e-10 | 9.141 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 1.293595e-09 | 8.888 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 7.454228e-09 | 8.128 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 7.454228e-09 | 8.128 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 1.292340e-08 | 7.889 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 2.023706e-08 | 7.694 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 3.711812e-08 | 7.430 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 5.993784e-08 | 7.222 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 8.507012e-08 | 7.070 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 1.330985e-07 | 6.876 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 1.356793e-07 | 6.867 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 1.514232e-07 | 6.820 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 1.600717e-07 | 6.796 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 1.694506e-07 | 6.771 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 1.914715e-07 | 6.718 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 2.162716e-07 | 6.665 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 2.162716e-07 | 6.665 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 2.187863e-07 | 6.660 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 2.477616e-07 | 6.606 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 2.841587e-07 | 6.546 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 3.372516e-07 | 6.472 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 4.951975e-07 | 6.305 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 4.924340e-07 | 6.308 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 7.730726e-07 | 6.112 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 9.318012e-07 | 6.031 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 1.146585e-06 | 5.941 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 1.190924e-06 | 5.924 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 1.501001e-06 | 5.824 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 1.541145e-06 | 5.812 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 1.758658e-06 | 5.755 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 2.096700e-06 | 5.678 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 2.096700e-06 | 5.678 | 0 | 0 |
| Regulation of TP53 Activity | R-HSA-5633007 | 2.624532e-06 | 5.581 | 1 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 3.716311e-06 | 5.430 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 4.500563e-06 | 5.347 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 4.590736e-06 | 5.338 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 4.655065e-06 | 5.332 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 4.867565e-06 | 5.313 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 8.653966e-06 | 5.063 | 0 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 9.101902e-06 | 5.041 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 9.857176e-06 | 5.006 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 1.088617e-05 | 4.963 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 1.237989e-05 | 4.907 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 1.362666e-05 | 4.866 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 1.491866e-05 | 4.826 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 1.617198e-05 | 4.791 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 1.714417e-05 | 4.766 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 1.833351e-05 | 4.737 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 1.813267e-05 | 4.742 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 1.803901e-05 | 4.744 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 1.921504e-05 | 4.716 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 1.882310e-05 | 4.725 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 1.935048e-05 | 4.713 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 2.110852e-05 | 4.676 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 2.319816e-05 | 4.635 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 2.621897e-05 | 4.581 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 3.211477e-05 | 4.493 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 3.758528e-05 | 4.425 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 3.973583e-05 | 4.401 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 4.675894e-05 | 4.330 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 4.806957e-05 | 4.318 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 4.983020e-05 | 4.303 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 6.679264e-05 | 4.175 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 6.897002e-05 | 4.161 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 7.312240e-05 | 4.136 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 8.196495e-05 | 4.086 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 9.605475e-05 | 4.017 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 1.045782e-04 | 3.981 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 1.144491e-04 | 3.941 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 1.233080e-04 | 3.909 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 1.272367e-04 | 3.895 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 1.314012e-04 | 3.881 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 1.453899e-04 | 3.837 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 1.661747e-04 | 3.779 | 0 | 0 |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | R-HSA-9828211 | 1.661747e-04 | 3.779 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 2.034705e-04 | 3.691 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 2.243413e-04 | 3.649 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 2.822599e-04 | 3.549 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 2.978401e-04 | 3.526 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 3.141078e-04 | 3.503 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 3.141078e-04 | 3.503 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 3.146834e-04 | 3.502 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 3.899724e-04 | 3.409 | 0 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 3.997429e-04 | 3.398 | 1 | 1 |
| Autophagy | R-HSA-9612973 | 3.938049e-04 | 3.405 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 4.108159e-04 | 3.386 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 4.364139e-04 | 3.360 | 0 | 0 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 4.364139e-04 | 3.360 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 4.448961e-04 | 3.352 | 0 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 4.237412e-04 | 3.373 | 0 | 0 |
| FLT3 signaling by CBL mutants | R-HSA-9706377 | 4.605119e-04 | 3.337 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 5.252692e-04 | 3.280 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 5.252692e-04 | 3.280 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 5.281653e-04 | 3.277 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 5.442198e-04 | 3.264 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 6.100801e-04 | 3.215 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 6.441660e-04 | 3.191 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 6.634879e-04 | 3.178 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 6.991551e-04 | 3.155 | 0 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 7.771342e-04 | 3.110 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 7.326018e-04 | 3.135 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 7.698346e-04 | 3.114 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 7.771342e-04 | 3.110 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 7.433960e-04 | 3.129 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 7.804731e-04 | 3.108 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 8.028266e-04 | 3.095 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 8.175616e-04 | 3.087 | 1 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 8.659105e-04 | 3.063 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 8.772710e-04 | 3.057 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 9.113346e-04 | 3.040 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 9.852736e-04 | 3.006 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 1.084157e-03 | 2.965 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 1.084157e-03 | 2.965 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 1.074322e-03 | 2.969 | 0 | 0 |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | R-HSA-9824878 | 1.239514e-03 | 2.907 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 1.268467e-03 | 2.897 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 1.239514e-03 | 2.907 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 1.184856e-03 | 2.926 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 1.202920e-03 | 2.920 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 1.258774e-03 | 2.900 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 1.294127e-03 | 2.888 | 1 | 0 |
| Meiosis | R-HSA-1500620 | 1.363145e-03 | 2.865 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 1.410081e-03 | 2.851 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 1.410081e-03 | 2.851 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 1.473130e-03 | 2.832 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 1.434746e-03 | 2.843 | 0 | 0 |
| Polo-like kinase mediated events | R-HSA-156711 | 1.490636e-03 | 2.827 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 1.490636e-03 | 2.827 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 1.498030e-03 | 2.824 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 1.424482e-03 | 2.846 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 1.473130e-03 | 2.832 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 1.514507e-03 | 2.820 | 0 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 1.563154e-03 | 2.806 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 1.658884e-03 | 2.780 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 1.798697e-03 | 2.745 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 1.798697e-03 | 2.745 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 1.828067e-03 | 2.738 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 1.828067e-03 | 2.738 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 2.005695e-03 | 2.698 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 1.943215e-03 | 2.711 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 1.857979e-03 | 2.731 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 1.893076e-03 | 2.723 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 1.944048e-03 | 2.711 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 2.024127e-03 | 2.694 | 0 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 2.060503e-03 | 2.686 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 2.064806e-03 | 2.685 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 2.295898e-03 | 2.639 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 2.253924e-03 | 2.647 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 2.182432e-03 | 2.661 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 2.342681e-03 | 2.630 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 2.342681e-03 | 2.630 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 2.374041e-03 | 2.625 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 2.374041e-03 | 2.625 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 2.374041e-03 | 2.625 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 2.374041e-03 | 2.625 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 2.374041e-03 | 2.625 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 2.374041e-03 | 2.625 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 2.374041e-03 | 2.625 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 2.374041e-03 | 2.625 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 2.374041e-03 | 2.625 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 2.374041e-03 | 2.625 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 2.374041e-03 | 2.625 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 2.701712e-03 | 2.568 | 0 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 2.515862e-03 | 2.599 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 2.515862e-03 | 2.599 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 2.701712e-03 | 2.568 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 2.508408e-03 | 2.601 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 2.448052e-03 | 2.611 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 2.620628e-03 | 2.582 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 2.886963e-03 | 2.540 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 2.969702e-03 | 2.527 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 2.979641e-03 | 2.526 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 3.000310e-03 | 2.523 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 3.051418e-03 | 2.515 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 3.085107e-03 | 2.511 | 0 | 0 |
| Kinesins | R-HSA-983189 | 3.201693e-03 | 2.495 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 3.293010e-03 | 2.482 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 3.293010e-03 | 2.482 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 3.750600e-03 | 2.426 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 3.549515e-03 | 2.450 | 0 | 0 |
| DNA methylation | R-HSA-5334118 | 3.726231e-03 | 2.429 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 3.763069e-03 | 2.424 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 3.763069e-03 | 2.424 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 3.763069e-03 | 2.424 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 3.763069e-03 | 2.424 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 3.737402e-03 | 2.427 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 3.524229e-03 | 2.453 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 3.733001e-03 | 2.428 | 0 | 0 |
| ChREBP activates metabolic gene expression | R-HSA-163765 | 3.484912e-03 | 2.458 | 0 | 0 |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | R-HSA-190840 | 3.733001e-03 | 2.428 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 3.793806e-03 | 2.421 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 3.808342e-03 | 2.419 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 4.254677e-03 | 2.371 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 4.402052e-03 | 2.356 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 4.402052e-03 | 2.356 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 4.416747e-03 | 2.355 | 0 | 0 |
| Loss of MECP2 binding ability to 5mC-DNA | R-HSA-9022538 | 5.211032e-03 | 2.283 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 5.143975e-03 | 2.289 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 5.143975e-03 | 2.289 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 4.949675e-03 | 2.305 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 4.949675e-03 | 2.305 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 5.135219e-03 | 2.289 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 4.630623e-03 | 2.334 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 4.699223e-03 | 2.328 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 4.595728e-03 | 2.338 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 5.034700e-03 | 2.298 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 5.001727e-03 | 2.301 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 5.034700e-03 | 2.298 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 5.143975e-03 | 2.289 | 0 | 0 |
| Transport of connexons to the plasma membrane | R-HSA-190872 | 4.949675e-03 | 2.305 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 5.244985e-03 | 2.280 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 4.948270e-03 | 2.306 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 5.345469e-03 | 2.272 | 0 | 0 |
| S Phase | R-HSA-69242 | 5.378781e-03 | 2.269 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 6.091636e-03 | 2.215 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 6.181675e-03 | 2.209 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 6.210399e-03 | 2.207 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 6.210399e-03 | 2.207 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 6.213843e-03 | 2.207 | 0 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 6.418786e-03 | 2.193 | 0 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 6.418786e-03 | 2.193 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 6.453529e-03 | 2.190 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 6.528364e-03 | 2.185 | 0 | 0 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | 6.628598e-03 | 2.179 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 6.628598e-03 | 2.179 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 6.855583e-03 | 2.164 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 6.864323e-03 | 2.163 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 6.962034e-03 | 2.157 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 6.962034e-03 | 2.157 | 0 | 0 |
| Post-chaperonin tubulin folding pathway | R-HSA-389977 | 8.285632e-03 | 2.082 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 8.285632e-03 | 2.082 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 8.285632e-03 | 2.082 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 8.285632e-03 | 2.082 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 8.285632e-03 | 2.082 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 8.167299e-03 | 2.088 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 8.044717e-03 | 2.094 | 0 | 0 |
| Cellular response to heat stress | R-HSA-3371556 | 7.544048e-03 | 2.122 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 7.319521e-03 | 2.136 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 8.131066e-03 | 2.090 | 0 | 0 |
| Signaling by LTK in cancer | R-HSA-9842640 | 8.397273e-03 | 2.076 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 8.430981e-03 | 2.074 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 8.430981e-03 | 2.074 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 8.430981e-03 | 2.074 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 8.617819e-03 | 2.065 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 8.648732e-03 | 2.063 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 8.668057e-03 | 2.062 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 9.079477e-03 | 2.042 | 0 | 0 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 9.079477e-03 | 2.042 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 9.232010e-03 | 2.035 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 9.338931e-03 | 2.030 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 9.392264e-03 | 2.027 | 0 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 9.401069e-03 | 2.027 | 0 | 0 |
| MECP2 regulates transcription of neuronal ligands | R-HSA-9022702 | 9.576031e-03 | 2.019 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 9.576031e-03 | 2.019 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 9.576031e-03 | 2.019 | 0 | 0 |
| Josephin domain DUBs | R-HSA-5689877 | 9.576031e-03 | 2.019 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 9.576031e-03 | 2.019 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 9.578525e-03 | 2.019 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 9.614959e-03 | 2.017 | 0 | 0 |
| FLT3 signaling through SRC family kinases | R-HSA-9706374 | 9.720345e-03 | 2.012 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 9.724321e-03 | 2.012 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 9.724321e-03 | 2.012 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 9.821185e-03 | 2.008 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 9.821185e-03 | 2.008 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 9.830399e-03 | 2.007 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 1.013133e-02 | 1.994 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 1.013133e-02 | 1.994 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 1.039950e-02 | 1.983 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 1.173220e-02 | 1.931 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 1.173220e-02 | 1.931 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 1.120988e-02 | 1.950 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 1.187454e-02 | 1.925 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 1.175446e-02 | 1.930 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 1.175446e-02 | 1.930 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 1.052010e-02 | 1.978 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 1.188497e-02 | 1.925 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 1.132185e-02 | 1.946 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 1.208569e-02 | 1.918 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 1.103151e-02 | 1.957 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 1.103151e-02 | 1.957 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 1.158686e-02 | 1.936 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 1.258038e-02 | 1.900 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 1.252769e-02 | 1.902 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 1.120988e-02 | 1.950 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 1.051289e-02 | 1.978 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 1.067052e-02 | 1.972 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 1.279820e-02 | 1.893 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 1.279820e-02 | 1.893 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 1.310343e-02 | 1.883 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 1.310343e-02 | 1.883 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 1.310343e-02 | 1.883 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 1.335501e-02 | 1.874 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 1.414629e-02 | 1.849 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 1.426359e-02 | 1.846 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 1.431700e-02 | 1.844 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 1.446494e-02 | 1.840 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 1.471318e-02 | 1.832 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 1.491528e-02 | 1.826 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 1.497124e-02 | 1.825 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 1.598527e-02 | 1.796 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 1.607119e-02 | 1.794 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 1.617386e-02 | 1.791 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 1.649175e-02 | 1.783 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 1.667597e-02 | 1.778 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 1.667597e-02 | 1.778 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 1.667597e-02 | 1.778 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 1.680394e-02 | 1.775 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 1.680394e-02 | 1.775 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 1.684827e-02 | 1.773 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 1.684827e-02 | 1.773 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 1.780875e-02 | 1.749 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 1.806912e-02 | 1.743 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 1.840417e-02 | 1.735 | 0 | 0 |
| Modulation by Mtb of host immune system | R-HSA-9637628 | 1.841193e-02 | 1.735 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 1.912107e-02 | 1.718 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 2.381163e-02 | 1.623 | 0 | 0 |
| Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 2.384340e-02 | 1.623 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 2.392713e-02 | 1.621 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 2.392713e-02 | 1.621 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 2.149271e-02 | 1.668 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 1.970237e-02 | 1.705 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 1.988310e-02 | 1.702 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 2.381163e-02 | 1.623 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 2.308425e-02 | 1.637 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 2.008040e-02 | 1.697 | 1 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 2.253833e-02 | 1.647 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 2.316781e-02 | 1.635 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 2.290181e-02 | 1.640 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 2.022629e-02 | 1.694 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 1.970237e-02 | 1.705 | 0 | 0 |
| Signal Transduction | R-HSA-162582 | 2.142942e-02 | 1.669 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 2.007509e-02 | 1.697 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 2.384340e-02 | 1.623 | 0 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 2.384340e-02 | 1.623 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 2.381163e-02 | 1.623 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 2.063570e-02 | 1.685 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 1.970237e-02 | 1.705 | 0 | 0 |
| Depurination | R-HSA-73927 | 2.290181e-02 | 1.640 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 2.205361e-02 | 1.657 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 2.205361e-02 | 1.657 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 2.421104e-02 | 1.616 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 2.421104e-02 | 1.616 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 2.434910e-02 | 1.614 | 0 | 0 |
| RUNX1 regulates expression of components of tight junctions | R-HSA-8935964 | 2.490212e-02 | 1.604 | 0 | 0 |
| Maturation of protein E | R-HSA-9683683 | 2.490212e-02 | 1.604 | 0 | 0 |
| Maturation of protein E | R-HSA-9694493 | 2.490212e-02 | 1.604 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 2.530832e-02 | 1.597 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 2.530832e-02 | 1.597 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex | R-HSA-937042 | 2.552383e-02 | 1.593 | 0 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 2.552383e-02 | 1.593 | 0 | 0 |
| Unwinding of DNA | R-HSA-176974 | 2.552383e-02 | 1.593 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 2.733381e-02 | 1.563 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 2.747018e-02 | 1.561 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 2.747018e-02 | 1.561 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 2.747018e-02 | 1.561 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 2.820679e-02 | 1.550 | 0 | 0 |
| DAP12 signaling | R-HSA-2424491 | 2.820679e-02 | 1.550 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 2.820679e-02 | 1.550 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 2.851948e-02 | 1.545 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 2.910196e-02 | 1.536 | 0 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 2.910196e-02 | 1.536 | 0 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 2.910196e-02 | 1.536 | 0 | 0 |
| MAP kinase activation | R-HSA-450294 | 3.041178e-02 | 1.517 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 3.041178e-02 | 1.517 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 3.042343e-02 | 1.517 | 0 | 0 |
| Membrane binding and targetting of GAG proteins | R-HSA-174490 | 3.066285e-02 | 1.513 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 3.066285e-02 | 1.513 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 3.067160e-02 | 1.513 | 0 | 0 |
| Formation of editosomes by ADAR proteins | R-HSA-77042 | 3.096329e-02 | 1.509 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 3.096329e-02 | 1.509 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 3.096329e-02 | 1.509 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 3.096329e-02 | 1.509 | 0 | 0 |
| Loss of MECP2 binding ability to 5hmC-DNA | R-HSA-9022534 | 3.096329e-02 | 1.509 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 3.096329e-02 | 1.509 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 3.096329e-02 | 1.509 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 3.180207e-02 | 1.498 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 3.182472e-02 | 1.497 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 3.182472e-02 | 1.497 | 0 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 3.219439e-02 | 1.492 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 3.257735e-02 | 1.487 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 3.285720e-02 | 1.483 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 3.300400e-02 | 1.481 | 0 | 0 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 3.300400e-02 | 1.481 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 3.380336e-02 | 1.471 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 3.391864e-02 | 1.470 | 0 | 0 |
| Pexophagy | R-HSA-9664873 | 3.418730e-02 | 1.466 | 0 | 0 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | 4.447396e-02 | 1.352 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 4.447396e-02 | 1.352 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | R-HSA-76071 | 4.055017e-02 | 1.392 | 0 | 0 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 3.972604e-02 | 1.401 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 3.718584e-02 | 1.430 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 4.190527e-02 | 1.378 | 0 | 0 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | R-HSA-9670439 | 4.055017e-02 | 1.392 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 3.868808e-02 | 1.412 | 0 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 4.382808e-02 | 1.358 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 4.056786e-02 | 1.392 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 4.425381e-02 | 1.354 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 3.478667e-02 | 1.459 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 4.404557e-02 | 1.356 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 4.425381e-02 | 1.354 | 0 | 0 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | R-HSA-174495 | 3.868808e-02 | 1.412 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 4.196157e-02 | 1.377 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 4.631466e-02 | 1.334 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 4.425381e-02 | 1.354 | 0 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 4.278169e-02 | 1.369 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 4.180314e-02 | 1.379 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 3.542756e-02 | 1.451 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 3.980576e-02 | 1.400 | 0 | 0 |
| Alpha-protein kinase 1 signaling pathway | R-HSA-9645460 | 4.447396e-02 | 1.352 | 0 | 0 |
| Signaling by KIT in disease | R-HSA-9669938 | 4.055017e-02 | 1.392 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 4.056786e-02 | 1.392 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 4.702998e-02 | 1.328 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 4.727615e-02 | 1.325 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 4.778372e-02 | 1.321 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 4.793624e-02 | 1.319 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 4.793624e-02 | 1.319 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 4.793624e-02 | 1.319 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 4.793624e-02 | 1.319 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 4.793624e-02 | 1.319 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 4.867869e-02 | 1.313 | 0 | 0 |
| MECP2 regulates transcription factors | R-HSA-9022707 | 4.939589e-02 | 1.306 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 4.939589e-02 | 1.306 | 0 | 0 |
| IFNG signaling activates MAPKs | R-HSA-9732724 | 4.939589e-02 | 1.306 | 0 | 0 |
| TLR3-mediated TICAM1-dependent programmed cell death | R-HSA-9013957 | 4.982751e-02 | 1.303 | 0 | 0 |
| p75NTR negatively regulates cell cycle via SC1 | R-HSA-193670 | 4.982751e-02 | 1.303 | 0 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 4.982751e-02 | 1.303 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 5.075083e-02 | 1.295 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 5.154321e-02 | 1.288 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 5.160121e-02 | 1.287 | 0 | 0 |
| Membrane Trafficking | R-HSA-199991 | 5.196283e-02 | 1.284 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 5.359198e-02 | 1.271 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 5.359198e-02 | 1.271 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 5.410965e-02 | 1.267 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 5.528212e-02 | 1.257 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 5.667304e-02 | 1.247 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 5.785359e-02 | 1.238 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 5.785359e-02 | 1.238 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 5.785359e-02 | 1.238 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 5.793014e-02 | 1.237 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 5.793014e-02 | 1.237 | 0 | 0 |
| Regulation of BACH1 activity | R-HSA-9708530 | 5.843908e-02 | 1.233 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 5.843908e-02 | 1.233 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 5.843908e-02 | 1.233 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 5.843908e-02 | 1.233 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 5.911003e-02 | 1.228 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 5.949448e-02 | 1.226 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 5.988310e-02 | 1.223 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 5.988310e-02 | 1.223 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 6.076282e-02 | 1.216 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 6.078713e-02 | 1.216 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 6.078713e-02 | 1.216 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 6.101793e-02 | 1.215 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 6.134742e-02 | 1.212 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 6.157609e-02 | 1.211 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 6.163861e-02 | 1.210 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 6.304334e-02 | 1.200 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 6.472025e-02 | 1.189 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 6.512672e-02 | 1.186 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 6.512672e-02 | 1.186 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 6.512672e-02 | 1.186 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 6.524736e-02 | 1.185 | 0 | 0 |
| Myoclonic epilepsy of Lafora | R-HSA-3785653 | 6.524736e-02 | 1.185 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 6.544643e-02 | 1.184 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 6.557604e-02 | 1.183 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 6.557604e-02 | 1.183 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 6.641973e-02 | 1.178 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 6.657988e-02 | 1.177 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 6.681629e-02 | 1.175 | 0 | 0 |
| Reelin signalling pathway | R-HSA-8866376 | 7.179920e-02 | 1.144 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 7.179920e-02 | 1.144 | 0 | 0 |
| Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 9.733122e-02 | 1.012 | 0 | 0 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 9.733122e-02 | 1.012 | 0 | 0 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | 9.733122e-02 | 1.012 | 0 | 0 |
| Loss of MECP2 binding ability to the NCoR/SMRT complex | R-HSA-9022537 | 9.733122e-02 | 1.012 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 8.342358e-02 | 1.079 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 7.004003e-02 | 1.155 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 7.004003e-02 | 1.155 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 7.004003e-02 | 1.155 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 7.004003e-02 | 1.155 | 0 | 0 |
| VLDLR internalisation and degradation | R-HSA-8866427 | 7.004003e-02 | 1.155 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 7.021093e-02 | 1.154 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 7.021093e-02 | 1.154 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 8.324897e-02 | 1.080 | 0 | 0 |
| ERK/MAPK targets | R-HSA-198753 | 6.819639e-02 | 1.166 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 7.948403e-02 | 1.100 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 7.948403e-02 | 1.100 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 9.178903e-02 | 1.037 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 7.028017e-02 | 1.153 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 7.028017e-02 | 1.153 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 8.572482e-02 | 1.067 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 8.987522e-02 | 1.046 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 8.291718e-02 | 1.081 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 7.812195e-02 | 1.107 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 7.182089e-02 | 1.144 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 7.913708e-02 | 1.102 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 7.913708e-02 | 1.102 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 8.691254e-02 | 1.061 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 9.638606e-02 | 1.016 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 7.047289e-02 | 1.152 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 9.101420e-02 | 1.041 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 7.043012e-02 | 1.152 | 0 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 1.021599e-01 | 0.991 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 7.501383e-02 | 1.125 | 0 | 0 |
| Signaling by NTRK2 (TRKB) | R-HSA-9006115 | 8.572482e-02 | 1.067 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 7.092135e-02 | 1.149 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 9.753392e-02 | 1.011 | 0 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 7.092135e-02 | 1.149 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 8.567322e-02 | 1.067 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 7.673787e-02 | 1.115 | 0 | 0 |
| Aryl hydrocarbon receptor signalling | R-HSA-8937144 | 9.733122e-02 | 1.012 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 7.948403e-02 | 1.100 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 9.178903e-02 | 1.037 | 0 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 8.567322e-02 | 1.067 | 0 | 0 |
| Protein folding | R-HSA-391251 | 7.125197e-02 | 1.147 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 8.572482e-02 | 1.067 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 8.308512e-02 | 1.080 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 9.753392e-02 | 1.011 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 7.312654e-02 | 1.136 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 8.501266e-02 | 1.071 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 7.021093e-02 | 1.154 | 0 | 0 |
| Signaling by FGFR4 in disease | R-HSA-5655291 | 1.021599e-01 | 0.991 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 7.499942e-02 | 1.125 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 7.705943e-02 | 1.113 | 0 | 0 |
| Inactivation of CSF3 (G-CSF) signaling | R-HSA-9705462 | 7.948403e-02 | 1.100 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 8.987522e-02 | 1.046 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 7.499942e-02 | 1.125 | 0 | 0 |
| Nectin/Necl trans heterodimerization | R-HSA-420597 | 7.179920e-02 | 1.144 | 0 | 0 |
| Sodium-coupled phosphate cotransporters | R-HSA-427652 | 9.733122e-02 | 1.012 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 8.342358e-02 | 1.079 | 0 | 0 |
| IRAK1 recruits IKK complex | R-HSA-937039 | 7.004003e-02 | 1.155 | 0 | 0 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | R-HSA-975144 | 7.004003e-02 | 1.155 | 0 | 0 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | R-HSA-5684264 | 1.021599e-01 | 0.991 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 8.691254e-02 | 1.061 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 8.191871e-02 | 1.087 | 0 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 9.178903e-02 | 1.037 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 1.007666e-01 | 0.997 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 7.392843e-02 | 1.131 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 7.272908e-02 | 1.138 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | R-HSA-9825892 | 7.948403e-02 | 1.100 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 7.047289e-02 | 1.152 | 0 | 0 |
| Assembly Of The HIV Virion | R-HSA-175474 | 7.948403e-02 | 1.100 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 8.984088e-02 | 1.047 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 7.021093e-02 | 1.154 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 9.753392e-02 | 1.011 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 9.733122e-02 | 1.012 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 8.691254e-02 | 1.061 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 8.987522e-02 | 1.046 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 1.028099e-01 | 0.988 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 1.028099e-01 | 0.988 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 1.028099e-01 | 0.988 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 1.031703e-01 | 0.986 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 1.037969e-01 | 0.984 | 0 | 0 |
| MET activates RAP1 and RAC1 | R-HSA-8875555 | 1.037969e-01 | 0.984 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 1.037969e-01 | 0.984 | 0 | 0 |
| PI3K/AKT activation | R-HSA-198203 | 1.037969e-01 | 0.984 | 0 | 0 |
| Signal attenuation | R-HSA-74749 | 1.037969e-01 | 0.984 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 1.037969e-01 | 0.984 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 1.038496e-01 | 0.984 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 1.038496e-01 | 0.984 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 1.038496e-01 | 0.984 | 0 | 0 |
| mRNA Editing: A to I Conversion | R-HSA-75064 | 1.039670e-01 | 0.983 | 0 | 0 |
| Regulation of TP53 Expression | R-HSA-6804754 | 1.039670e-01 | 0.983 | 0 | 0 |
| C6 deamination of adenosine | R-HSA-75102 | 1.039670e-01 | 0.983 | 0 | 0 |
| Regulation of cortical dendrite branching | R-HSA-8985801 | 1.039670e-01 | 0.983 | 0 | 0 |
| TGFBR1 LBD Mutants in Cancer | R-HSA-3656535 | 1.039670e-01 | 0.983 | 0 | 0 |
| Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) | R-HSA-1299308 | 1.039670e-01 | 0.983 | 0 | 0 |
| Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 1.050970e-01 | 0.978 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 1.050970e-01 | 0.978 | 0 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 1.050970e-01 | 0.978 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 1.083314e-01 | 0.965 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 1.087937e-01 | 0.963 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 1.097130e-01 | 0.960 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 1.118580e-01 | 0.951 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 1.123790e-01 | 0.949 | 0 | 0 |
| Gap junction assembly | R-HSA-190861 | 1.123790e-01 | 0.949 | 0 | 0 |
| Translesion Synthesis by POLH | R-HSA-110320 | 1.130311e-01 | 0.947 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 1.130311e-01 | 0.947 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 1.130311e-01 | 0.947 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 1.137070e-01 | 0.944 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 1.140920e-01 | 0.943 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 1.140920e-01 | 0.943 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 1.140920e-01 | 0.943 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 1.140920e-01 | 0.943 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 1.174089e-01 | 0.930 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 1.193836e-01 | 0.923 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 1.205361e-01 | 0.919 | 0 | 0 |
| Translesion synthesis by REV1 | R-HSA-110312 | 1.205361e-01 | 0.919 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 1.205361e-01 | 0.919 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 1.205361e-01 | 0.919 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 1.205361e-01 | 0.919 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 1.225509e-01 | 0.912 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 1.226289e-01 | 0.911 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 1.229480e-01 | 0.910 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 1.239821e-01 | 0.907 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 1.252270e-01 | 0.902 | 0 | 0 |
| G2/M DNA replication checkpoint | R-HSA-69478 | 1.259563e-01 | 0.900 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 1.259563e-01 | 0.900 | 0 | 0 |
| Nef and signal transduction | R-HSA-164944 | 1.259563e-01 | 0.900 | 0 | 0 |
| Drug resistance of FLT3 mutants | R-HSA-9702506 | 1.272690e-01 | 0.895 | 0 | 0 |
| Drug resistance of PDGFR mutants | R-HSA-9674415 | 1.272690e-01 | 0.895 | 0 | 0 |
| PDGFR mutants bind TKIs | R-HSA-9674428 | 1.272690e-01 | 0.895 | 0 | 0 |
| FLT3 mutants bind TKIs | R-HSA-9702509 | 1.272690e-01 | 0.895 | 0 | 0 |
| Deletions in the AMER1 gene destabilize the destruction complex | R-HSA-5467343 | 1.272690e-01 | 0.895 | 0 | 0 |
| Sunitinib-resistant PDGFR mutants | R-HSA-9674401 | 1.272690e-01 | 0.895 | 0 | 0 |
| linifanib-resistant FLT3 mutants | R-HSA-9702998 | 1.272690e-01 | 0.895 | 0 | 0 |
| Sorafenib-resistant PDGFR mutants | R-HSA-9674404 | 1.272690e-01 | 0.895 | 0 | 0 |
| midostaurin-resistant FLT3 mutants | R-HSA-9702600 | 1.272690e-01 | 0.895 | 0 | 0 |
| sunitinib-resistant FLT3 mutants | R-HSA-9702632 | 1.272690e-01 | 0.895 | 0 | 0 |
| Loss of function of TP53 in cancer due to loss of tetramerization ability | R-HSA-9723905 | 1.272690e-01 | 0.895 | 0 | 0 |
| APC truncation mutants are not K63 polyubiquitinated | R-HSA-5467333 | 1.272690e-01 | 0.895 | 0 | 0 |
| Loss of Function of TP53 in Cancer | R-HSA-9723907 | 1.272690e-01 | 0.895 | 0 | 0 |
| lestaurtinib-resistant FLT3 mutants | R-HSA-9702596 | 1.272690e-01 | 0.895 | 0 | 0 |
| pexidartinib-resistant FLT3 mutants | R-HSA-9702605 | 1.272690e-01 | 0.895 | 0 | 0 |
| KW2449-resistant FLT3 mutants | R-HSA-9702569 | 1.272690e-01 | 0.895 | 0 | 0 |
| tamatinib-resistant FLT3 mutants | R-HSA-9703009 | 1.272690e-01 | 0.895 | 0 | 0 |
| ponatinib-resistant FLT3 mutants | R-HSA-9702614 | 1.272690e-01 | 0.895 | 0 | 0 |
| crenolanib-resistant FLT3 mutants | R-HSA-9702581 | 1.272690e-01 | 0.895 | 0 | 0 |
| Imatinib-resistant PDGFR mutants | R-HSA-9674396 | 1.272690e-01 | 0.895 | 0 | 0 |
| sorafenib-resistant FLT3 mutants | R-HSA-9702624 | 1.272690e-01 | 0.895 | 0 | 0 |
| gilteritinib-resistant FLT3 mutants | R-HSA-9702590 | 1.272690e-01 | 0.895 | 0 | 0 |
| quizartinib-resistant FLT3 mutants | R-HSA-9702620 | 1.272690e-01 | 0.895 | 0 | 0 |
| Regorafenib-resistant PDGFR mutants | R-HSA-9674403 | 1.272690e-01 | 0.895 | 0 | 0 |
| semaxanib-resistant FLT3 mutants | R-HSA-9702577 | 1.272690e-01 | 0.895 | 0 | 0 |
| tandutinib-resistant FLT3 mutants | R-HSA-9702636 | 1.272690e-01 | 0.895 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 1.277026e-01 | 0.894 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 1.281093e-01 | 0.892 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 1.281093e-01 | 0.892 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 1.296916e-01 | 0.887 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 1.296916e-01 | 0.887 | 0 | 0 |
| Signaling by NODAL | R-HSA-1181150 | 1.296916e-01 | 0.887 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 1.304901e-01 | 0.884 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 1.320012e-01 | 0.879 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 1.346153e-01 | 0.871 | 0 | 0 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 1.362643e-01 | 0.866 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 1.369804e-01 | 0.863 | 0 | 0 |
| Translesion synthesis by POLI | R-HSA-5656121 | 1.403352e-01 | 0.853 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 1.403698e-01 | 0.853 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 1.448256e-01 | 0.839 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 1.481573e-01 | 0.829 | 0 | 0 |
| MET interacts with TNS proteins | R-HSA-8875513 | 1.490795e-01 | 0.827 | 0 | 0 |
| Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | R-HSA-9673766 | 1.490795e-01 | 0.827 | 0 | 0 |
| STAT6-mediated induction of chemokines | R-HSA-3249367 | 1.490795e-01 | 0.827 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 1.504249e-01 | 0.823 | 0 | 0 |
| Cytochrome c-mediated apoptotic response | R-HSA-111461 | 1.504249e-01 | 0.823 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 1.504625e-01 | 0.823 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 1.507502e-01 | 0.822 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 1.507502e-01 | 0.822 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 1.507840e-01 | 0.822 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 1.513911e-01 | 0.820 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 1.517803e-01 | 0.819 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 1.517803e-01 | 0.819 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 1.517803e-01 | 0.819 | 0 | 0 |
| Activated NTRK3 signals through PI3K | R-HSA-9603381 | 1.571673e-01 | 0.804 | 0 | 0 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 1.571673e-01 | 0.804 | 0 | 0 |
| SOS-mediated signalling | R-HSA-112412 | 1.571673e-01 | 0.804 | 0 | 0 |
| Uptake and function of diphtheria toxin | R-HSA-5336415 | 1.571673e-01 | 0.804 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 1.605685e-01 | 0.794 | 0 | 0 |
| Translesion synthesis by POLK | R-HSA-5655862 | 1.614439e-01 | 0.792 | 0 | 0 |
| Disorders of Developmental Biology | R-HSA-9675151 | 1.614439e-01 | 0.792 | 0 | 0 |
| UNC93B1 deficiency - HSE | R-HSA-5602415 | 2.383471e-01 | 0.623 | 0 | 0 |
| Defective DNA double strand break response due to BRCA1 loss of function | R-HSA-9663199 | 2.383471e-01 | 0.623 | 0 | 0 |
| Defective DNA double strand break response due to BARD1 loss of function | R-HSA-9699150 | 2.383471e-01 | 0.623 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH6 | R-HSA-5632968 | 2.383471e-01 | 0.623 | 0 | 0 |
| Impaired BRCA2 binding to SEM1 (DSS1) | R-HSA-9763198 | 2.383471e-01 | 0.623 | 0 | 0 |
| Hereditary fructose intolerance | R-HSA-5657560 | 2.383471e-01 | 0.623 | 0 | 0 |
| Impaired BRCA2 translocation to the nucleus | R-HSA-9709275 | 2.383471e-01 | 0.623 | 0 | 0 |
| Defective ACTH causes obesity and POMCD | R-HSA-5579031 | 2.383471e-01 | 0.623 | 0 | 0 |
| TICAM1 deficiency - HSE | R-HSA-5602566 | 2.383471e-01 | 0.623 | 0 | 0 |
| MECP2 regulates transcription of genes involved in GABA signaling | R-HSA-9022927 | 1.972259e-01 | 0.705 | 0 | 0 |
| Regulation of gap junction activity | R-HSA-191650 | 1.972259e-01 | 0.705 | 0 | 0 |
| Activated NTRK2 signals through PLCG1 | R-HSA-9026527 | 1.972259e-01 | 0.705 | 0 | 0 |
| Inhibition of TSC complex formation by PKB | R-HSA-165181 | 1.972259e-01 | 0.705 | 0 | 0 |
| RUNX2 regulates genes involved in differentiation of myeloid cells | R-HSA-8941333 | 1.972259e-01 | 0.705 | 0 | 0 |
| NFE2L2 regulating ER-stress associated genes | R-HSA-9818035 | 1.972259e-01 | 0.705 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 1.972259e-01 | 0.705 | 0 | 0 |
| Signaling by MAP2K mutants | R-HSA-9652169 | 1.972259e-01 | 0.705 | 0 | 0 |
| NrCAM interactions | R-HSA-447038 | 2.469043e-01 | 0.607 | 0 | 0 |
| RUNX2 regulates chondrocyte maturation | R-HSA-8941284 | 2.469043e-01 | 0.607 | 0 | 0 |
| IRS activation | R-HSA-74713 | 2.469043e-01 | 0.607 | 0 | 0 |
| Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 2.469043e-01 | 0.607 | 0 | 0 |
| NTRK2 activates RAC1 | R-HSA-9032759 | 2.469043e-01 | 0.607 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 2.469043e-01 | 0.607 | 0 | 0 |
| Activated NTRK2 signals through FYN | R-HSA-9032500 | 1.904479e-01 | 0.720 | 0 | 0 |
| Formyl peptide receptors bind formyl peptides and many other ligands | R-HSA-444473 | 1.904479e-01 | 0.720 | 0 | 0 |
| Activated NTRK2 signals through PI3K | R-HSA-9028335 | 1.904479e-01 | 0.720 | 0 | 0 |
| MET receptor recycling | R-HSA-8875656 | 1.904479e-01 | 0.720 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 1.904479e-01 | 0.720 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 1.762552e-01 | 0.754 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 2.252943e-01 | 0.647 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 2.252943e-01 | 0.647 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 2.252943e-01 | 0.647 | 0 | 0 |
| Phosphorylation of Emi1 | R-HSA-176417 | 2.969453e-01 | 0.527 | 0 | 0 |
| SLIT2:ROBO1 increases RHOA activity | R-HSA-8985586 | 2.969453e-01 | 0.527 | 0 | 0 |
| Loss of Function of SMAD2/3 in Cancer | R-HSA-3304349 | 2.969453e-01 | 0.527 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 2.034523e-01 | 0.692 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 2.612301e-01 | 0.583 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 2.612301e-01 | 0.583 | 0 | 0 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | R-HSA-2151209 | 2.612301e-01 | 0.583 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 1.837353e-01 | 0.736 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 1.662464e-01 | 0.779 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 2.070725e-01 | 0.684 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 1.859867e-01 | 0.731 | 0 | 0 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 2.978162e-01 | 0.526 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 1.677386e-01 | 0.775 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 1.677386e-01 | 0.775 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 2.609787e-01 | 0.583 | 0 | 0 |
| Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | R-HSA-9673767 | 2.609787e-01 | 0.583 | 0 | 0 |
| Signaling by PDGFRA extracellular domain mutants | R-HSA-9673770 | 2.609787e-01 | 0.583 | 0 | 0 |
| p38MAPK events | R-HSA-171007 | 2.609787e-01 | 0.583 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 1.855241e-01 | 0.732 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 1.855241e-01 | 0.732 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 2.040448e-01 | 0.690 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 2.040448e-01 | 0.690 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 2.040448e-01 | 0.690 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 2.279499e-01 | 0.642 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 2.908305e-01 | 0.536 | 0 | 0 |
| Class I peroxisomal membrane protein import | R-HSA-9603798 | 2.908305e-01 | 0.536 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 2.908305e-01 | 0.536 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 2.819090e-01 | 0.550 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 1.961600e-01 | 0.707 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 1.961600e-01 | 0.707 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 1.961600e-01 | 0.707 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 2.178690e-01 | 0.662 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 2.430209e-01 | 0.614 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 2.430209e-01 | 0.614 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 1.915939e-01 | 0.718 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 2.733092e-01 | 0.563 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 3.190445e-01 | 0.496 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 3.190445e-01 | 0.496 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 2.362853e-01 | 0.627 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 1.834880e-01 | 0.736 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 3.266615e-01 | 0.486 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 3.041573e-01 | 0.517 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 2.369135e-01 | 0.625 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 2.990173e-01 | 0.524 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 2.770272e-01 | 0.557 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 3.190445e-01 | 0.496 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 1.961600e-01 | 0.707 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 2.733092e-01 | 0.563 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 2.070725e-01 | 0.684 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 1.859867e-01 | 0.731 | 1 | 1 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 1.673121e-01 | 0.776 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 1.959252e-01 | 0.708 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 1.961600e-01 | 0.707 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 2.699289e-01 | 0.569 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 2.122127e-01 | 0.673 | 0 | 0 |
| Receptor Mediated Mitophagy | R-HSA-8934903 | 2.612301e-01 | 0.583 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 3.215109e-01 | 0.493 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 2.034523e-01 | 0.692 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 2.081402e-01 | 0.682 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 2.958116e-01 | 0.529 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 2.122127e-01 | 0.673 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 2.537015e-01 | 0.596 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 2.362853e-01 | 0.627 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 2.287658e-01 | 0.641 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 2.733092e-01 | 0.563 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 2.805206e-01 | 0.552 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 3.211035e-01 | 0.493 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 1.806479e-01 | 0.743 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 2.870449e-01 | 0.542 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 2.699289e-01 | 0.569 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 1.773275e-01 | 0.751 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 1.961600e-01 | 0.707 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 2.991062e-01 | 0.524 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 2.149997e-01 | 0.668 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 3.041573e-01 | 0.517 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 1.972259e-01 | 0.705 | 0 | 0 |
| Advanced glycosylation endproduct receptor signaling | R-HSA-879415 | 1.762552e-01 | 0.754 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 2.070725e-01 | 0.684 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 1.673121e-01 | 0.776 | 0 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 2.358788e-01 | 0.627 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 2.358788e-01 | 0.627 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 1.788402e-01 | 0.748 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 2.537015e-01 | 0.596 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 2.537015e-01 | 0.596 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 2.667632e-01 | 0.574 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 2.056080e-01 | 0.687 | 1 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 2.543778e-01 | 0.595 | 0 | 0 |
| NADE modulates death signalling | R-HSA-205025 | 1.972259e-01 | 0.705 | 0 | 0 |
| Pyrophosphate hydrolysis | R-HSA-71737 | 2.469043e-01 | 0.607 | 0 | 0 |
| RUNX3 regulates CDKN1A transcription | R-HSA-8941855 | 2.969453e-01 | 0.527 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 1.961600e-01 | 0.707 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 2.122127e-01 | 0.673 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 2.600142e-01 | 0.585 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 2.372624e-01 | 0.625 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 2.287658e-01 | 0.641 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 2.255682e-01 | 0.647 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 2.206601e-01 | 0.656 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 1.950554e-01 | 0.710 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 3.216656e-01 | 0.493 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 3.071000e-01 | 0.513 | 0 | 0 |
| DAP12 interactions | R-HSA-2172127 | 1.772234e-01 | 0.751 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 2.313121e-01 | 0.636 | 0 | 0 |
| Signaling by Activin | R-HSA-1502540 | 2.609787e-01 | 0.583 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 2.563069e-01 | 0.591 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 2.004036e-01 | 0.698 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 2.178690e-01 | 0.662 | 0 | 0 |
| Insulin receptor signalling cascade | R-HSA-74751 | 2.805206e-01 | 0.552 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 2.289338e-01 | 0.640 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 2.587398e-01 | 0.587 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 3.266615e-01 | 0.486 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 2.467848e-01 | 0.608 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 2.924052e-01 | 0.534 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 1.772930e-01 | 0.751 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 1.773275e-01 | 0.751 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 2.990173e-01 | 0.524 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 2.043463e-01 | 0.690 | 0 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 2.430209e-01 | 0.614 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 2.289338e-01 | 0.640 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 2.457770e-01 | 0.609 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 2.507302e-01 | 0.601 | 0 | 0 |
| SDK interactions | R-HSA-373756 | 2.383471e-01 | 0.623 | 0 | 0 |
| MTF1 activates gene expression | R-HSA-5660489 | 1.972259e-01 | 0.705 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in BCR signaling | R-HSA-8939245 | 2.469043e-01 | 0.607 | 0 | 0 |
| Co-stimulation by ICOS | R-HSA-9927354 | 1.904479e-01 | 0.720 | 0 | 0 |
| Signaling by LTK | R-HSA-9842663 | 1.762552e-01 | 0.754 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 1.662464e-01 | 0.779 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 2.978162e-01 | 0.526 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 1.835349e-01 | 0.736 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 2.040448e-01 | 0.690 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 2.279499e-01 | 0.642 | 0 | 0 |
| Mitochondrial calcium ion transport | R-HSA-8949215 | 3.079720e-01 | 0.511 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 2.819090e-01 | 0.550 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 2.843573e-01 | 0.546 | 0 | 0 |
| Signaling by NTRK3 (TRKC) | R-HSA-9034015 | 3.079720e-01 | 0.511 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 1.773275e-01 | 0.751 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 1.773275e-01 | 0.751 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 1.772234e-01 | 0.751 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 1.876390e-01 | 0.727 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 2.991062e-01 | 0.524 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 2.279499e-01 | 0.642 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 2.840939e-01 | 0.547 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 2.712808e-01 | 0.567 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 2.840939e-01 | 0.547 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 2.252943e-01 | 0.647 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 2.926144e-01 | 0.534 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 2.532732e-01 | 0.596 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 3.095639e-01 | 0.509 | 0 | 0 |
| Epithelial-Mesenchymal Transition (EMT) during gastrulation | R-HSA-9758919 | 2.969453e-01 | 0.527 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in apoptosis | R-HSA-9824594 | 2.819090e-01 | 0.550 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 2.358788e-01 | 0.627 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 2.064594e-01 | 0.685 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 3.052289e-01 | 0.515 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 3.266615e-01 | 0.486 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 1.717378e-01 | 0.765 | 0 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 2.230859e-01 | 0.652 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 1.959485e-01 | 0.708 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 2.499792e-01 | 0.602 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 2.081402e-01 | 0.682 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 2.334913e-01 | 0.632 | 0 | 0 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | R-HSA-2691230 | 1.762552e-01 | 0.754 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | R-HSA-2691232 | 1.762552e-01 | 0.754 | 0 | 0 |
| Golgi Cisternae Pericentriolar Stack Reorganization | R-HSA-162658 | 2.034523e-01 | 0.692 | 0 | 0 |
| Regulation of the apoptosome activity | R-HSA-9627069 | 2.612301e-01 | 0.583 | 0 | 0 |
| CD163 mediating an anti-inflammatory response | R-HSA-9662834 | 2.978162e-01 | 0.526 | 0 | 0 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 2.819090e-01 | 0.550 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 1.806479e-01 | 0.743 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 2.819090e-01 | 0.550 | 0 | 0 |
| Calnexin/calreticulin cycle | R-HSA-901042 | 3.266615e-01 | 0.486 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 3.174913e-01 | 0.498 | 0 | 0 |
| Formation of apoptosome | R-HSA-111458 | 2.612301e-01 | 0.583 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 2.622696e-01 | 0.581 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 2.252943e-01 | 0.647 | 0 | 0 |
| PD-L1(CD274) glycosylation and translocation to plasma membrane | R-HSA-9931295 | 2.819090e-01 | 0.550 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 1.655410e-01 | 0.781 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 2.430209e-01 | 0.614 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 2.122127e-01 | 0.673 | 0 | 0 |
| ER Quality Control Compartment (ERQC) | R-HSA-901032 | 2.956286e-01 | 0.529 | 0 | 0 |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | R-HSA-975110 | 3.211035e-01 | 0.493 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 3.175983e-01 | 0.498 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 3.056199e-01 | 0.515 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 2.232339e-01 | 0.651 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 2.600142e-01 | 0.585 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 3.289326e-01 | 0.483 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 3.321092e-01 | 0.479 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 3.321092e-01 | 0.479 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 3.343532e-01 | 0.476 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 3.343532e-01 | 0.476 | 0 | 0 |
| ERKs are inactivated | R-HSA-202670 | 3.346563e-01 | 0.475 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 3.346563e-01 | 0.475 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 3.346563e-01 | 0.475 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperone genes | R-HSA-381183 | 3.346563e-01 | 0.475 | 0 | 0 |
| Loss of Function of SMAD4 in Cancer | R-HSA-3304347 | 3.352931e-01 | 0.475 | 0 | 0 |
| SMAD2/3 MH2 Domain Mutants in Cancer | R-HSA-3315487 | 3.352931e-01 | 0.475 | 0 | 0 |
| Defective SLC17A5 causes Salla disease (SD) and ISSD | R-HSA-5619035 | 3.352931e-01 | 0.475 | 0 | 0 |
| SMAD4 MH2 Domain Mutants in Cancer | R-HSA-3311021 | 3.352931e-01 | 0.475 | 0 | 0 |
| Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) | R-HSA-5619045 | 3.352931e-01 | 0.475 | 0 | 0 |
| Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | R-HSA-5619111 | 3.352931e-01 | 0.475 | 0 | 0 |
| Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) | R-HSA-5619054 | 3.352931e-01 | 0.475 | 0 | 0 |
| Defective TPMT causes TPMT deficiency | R-HSA-5578995 | 3.352931e-01 | 0.475 | 0 | 0 |
| Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) | R-HSA-5619050 | 3.352931e-01 | 0.475 | 0 | 0 |
| Signaling by TCF7L2 mutants | R-HSA-5339700 | 3.352931e-01 | 0.475 | 0 | 0 |
| IKBKB deficiency causes SCID | R-HSA-5602636 | 3.352931e-01 | 0.475 | 0 | 0 |
| TRAF3 deficiency - HSE | R-HSA-5602571 | 3.352931e-01 | 0.475 | 0 | 0 |
| IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | R-HSA-5603027 | 3.352931e-01 | 0.475 | 0 | 0 |
| Defective SLC34A2 causes PALM | R-HSA-5687583 | 3.352931e-01 | 0.475 | 0 | 0 |
| Manipulation of host energy metabolism | R-HSA-9636667 | 3.352931e-01 | 0.475 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH2 | R-HSA-5632928 | 3.352931e-01 | 0.475 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 3.352931e-01 | 0.475 | 0 | 0 |
| Carboxyterminal post-translational modifications of tubulin | R-HSA-8955332 | 3.361008e-01 | 0.474 | 0 | 0 |
| PLC beta mediated events | R-HSA-112043 | 3.412793e-01 | 0.467 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 3.412793e-01 | 0.467 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 3.429268e-01 | 0.465 | 0 | 0 |
| CREB phosphorylation | R-HSA-199920 | 3.464525e-01 | 0.460 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 3.464525e-01 | 0.460 | 0 | 0 |
| STAT5 Activation | R-HSA-9645135 | 3.464525e-01 | 0.460 | 0 | 0 |
| RAS signaling downstream of NF1 loss-of-function variants | R-HSA-6802953 | 3.464525e-01 | 0.460 | 0 | 0 |
| E2F-enabled inhibition of pre-replication complex formation | R-HSA-113507 | 3.464525e-01 | 0.460 | 0 | 0 |
| Neurofascin interactions | R-HSA-447043 | 3.464525e-01 | 0.460 | 0 | 0 |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | R-HSA-2980767 | 3.464525e-01 | 0.460 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 3.483164e-01 | 0.458 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 3.494439e-01 | 0.457 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 3.515847e-01 | 0.454 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 3.515847e-01 | 0.454 | 0 | 0 |
| Regulation of FZD by ubiquitination | R-HSA-4641263 | 3.515847e-01 | 0.454 | 0 | 0 |
| Modulation of host responses by IFN-stimulated genes | R-HSA-9909505 | 3.515847e-01 | 0.454 | 0 | 0 |
| Glycogen storage diseases | R-HSA-3229121 | 3.515847e-01 | 0.454 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 3.521801e-01 | 0.453 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 3.567816e-01 | 0.448 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 3.589522e-01 | 0.445 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 3.594075e-01 | 0.444 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 3.596634e-01 | 0.444 | 0 | 0 |
| Response of EIF2AK1 (HRI) to heme deficiency | R-HSA-9648895 | 3.609153e-01 | 0.443 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 3.609153e-01 | 0.443 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 3.609153e-01 | 0.443 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 3.665584e-01 | 0.436 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 3.665584e-01 | 0.436 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 3.683867e-01 | 0.434 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 3.701196e-01 | 0.432 | 0 | 0 |
| HSF1 activation | R-HSA-3371511 | 3.701196e-01 | 0.432 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 3.701196e-01 | 0.432 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 3.701196e-01 | 0.432 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 3.713996e-01 | 0.430 | 0 | 0 |
| Activated NTRK2 signals through FRS2 and FRS3 | R-HSA-9028731 | 3.713996e-01 | 0.430 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 3.713996e-01 | 0.430 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 3.719778e-01 | 0.429 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 3.740653e-01 | 0.427 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 3.750812e-01 | 0.426 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 3.800634e-01 | 0.420 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 3.820765e-01 | 0.418 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 3.820765e-01 | 0.418 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 3.820765e-01 | 0.418 | 0 | 0 |
| Apoptotic factor-mediated response | R-HSA-111471 | 3.820765e-01 | 0.418 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 3.842169e-01 | 0.415 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 3.875279e-01 | 0.412 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 3.904343e-01 | 0.408 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 3.904644e-01 | 0.408 | 0 | 0 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 3.904644e-01 | 0.408 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 3.912940e-01 | 0.407 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 3.919991e-01 | 0.407 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 3.919991e-01 | 0.407 | 0 | 0 |
| IRS-mediated signalling | R-HSA-112399 | 3.925382e-01 | 0.406 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 3.926769e-01 | 0.406 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 3.927973e-01 | 0.406 | 0 | 0 |
| PI3K Cascade | R-HSA-109704 | 3.927973e-01 | 0.406 | 0 | 0 |
| MET activates PI3K/AKT signaling | R-HSA-8851907 | 3.947514e-01 | 0.404 | 0 | 0 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | 3.947514e-01 | 0.404 | 0 | 0 |
| Binding of TCF/LEF:CTNNB1 to target gene promoters | R-HSA-4411364 | 3.947514e-01 | 0.404 | 0 | 0 |
| Disinhibition of SNARE formation | R-HSA-114516 | 3.947514e-01 | 0.404 | 0 | 0 |
| Recycling of eIF2:GDP | R-HSA-72731 | 3.947514e-01 | 0.404 | 0 | 0 |
| Microbial modulation of RIPK1-mediated regulated necrosis | R-HSA-9686347 | 3.947514e-01 | 0.404 | 0 | 0 |
| Activation of PUMA and translocation to mitochondria | R-HSA-139915 | 3.947514e-01 | 0.404 | 0 | 0 |
| TGFBR3 regulates TGF-beta signaling | R-HSA-9839389 | 3.947514e-01 | 0.404 | 0 | 0 |
| RUNX3 Regulates Immune Response and Cell Migration | R-HSA-8949275 | 3.947514e-01 | 0.404 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 3.999917e-01 | 0.398 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 4.042419e-01 | 0.393 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 4.044329e-01 | 0.393 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 4.060090e-01 | 0.391 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 4.077415e-01 | 0.390 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 4.077415e-01 | 0.390 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperones | R-HSA-381033 | 4.077415e-01 | 0.390 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 4.080695e-01 | 0.389 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 4.092178e-01 | 0.388 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 4.092178e-01 | 0.388 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 4.118293e-01 | 0.385 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 4.123983e-01 | 0.385 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 4.123983e-01 | 0.385 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 4.129899e-01 | 0.384 | 0 | 0 |
| G1 Phase | R-HSA-69236 | 4.129899e-01 | 0.384 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 4.138855e-01 | 0.383 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 4.140686e-01 | 0.383 | 0 | 0 |
| BDNF activates NTRK2 (TRKB) signaling | R-HSA-9024909 | 4.199045e-01 | 0.377 | 0 | 0 |
| TGFBR2 Kinase Domain Mutants in Cancer | R-HSA-3645790 | 4.199045e-01 | 0.377 | 0 | 0 |
| Signaling by RAS GAP mutants | R-HSA-9753510 | 4.199045e-01 | 0.377 | 0 | 0 |
| tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | R-HSA-9708296 | 4.199045e-01 | 0.377 | 0 | 0 |
| Loss of Function of TGFBR2 in Cancer | R-HSA-3642278 | 4.199045e-01 | 0.377 | 0 | 0 |
| Neurophilin interactions with VEGF and VEGFR | R-HSA-194306 | 4.199045e-01 | 0.377 | 0 | 0 |
| Stimulation of the cell death response by PAK-2p34 | R-HSA-211736 | 4.199045e-01 | 0.377 | 0 | 0 |
| Activation, myristolyation of BID and translocation to mitochondria | R-HSA-75108 | 4.199045e-01 | 0.377 | 0 | 0 |
| ATF6B (ATF6-beta) activates chaperones | R-HSA-8874177 | 4.199045e-01 | 0.377 | 0 | 0 |
| Synthesis and processing of ENV and VPU | R-HSA-171286 | 4.199045e-01 | 0.377 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 4.308525e-01 | 0.366 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 4.332736e-01 | 0.363 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 4.344392e-01 | 0.362 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 4.381263e-01 | 0.358 | 0 | 0 |
| Caspase activation via extrinsic apoptotic signalling pathway | R-HSA-5357769 | 4.404236e-01 | 0.356 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 4.404236e-01 | 0.356 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 4.404236e-01 | 0.356 | 0 | 0 |
| Regulation by c-FLIP | R-HSA-3371378 | 4.413478e-01 | 0.355 | 0 | 0 |
| Nef mediated downregulation of MHC class I complex cell surface expression | R-HSA-164940 | 4.413478e-01 | 0.355 | 0 | 0 |
| EGFR interacts with phospholipase C-gamma | R-HSA-212718 | 4.413478e-01 | 0.355 | 0 | 0 |
| phospho-PLA2 pathway | R-HSA-111995 | 4.413478e-01 | 0.355 | 0 | 0 |
| Dimerization of procaspase-8 | R-HSA-69416 | 4.413478e-01 | 0.355 | 0 | 0 |
| Adrenoceptors | R-HSA-390696 | 4.413478e-01 | 0.355 | 0 | 0 |
| RSK activation | R-HSA-444257 | 4.413478e-01 | 0.355 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 4.413478e-01 | 0.355 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | R-HSA-8939246 | 4.413478e-01 | 0.355 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 4.423873e-01 | 0.354 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 4.425522e-01 | 0.354 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 4.431849e-01 | 0.353 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 4.464061e-01 | 0.350 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 4.464061e-01 | 0.350 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 4.464061e-01 | 0.350 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 4.464061e-01 | 0.350 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 4.464061e-01 | 0.350 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 4.509539e-01 | 0.346 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 4.534765e-01 | 0.343 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 4.534765e-01 | 0.343 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 4.565989e-01 | 0.340 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 4.574166e-01 | 0.340 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 4.574166e-01 | 0.340 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 4.574166e-01 | 0.340 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 4.601906e-01 | 0.337 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 4.628069e-01 | 0.335 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 4.637660e-01 | 0.334 | 0 | 0 |
| Signaling by FGFR3 in disease | R-HSA-5655332 | 4.664888e-01 | 0.331 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 4.673453e-01 | 0.330 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 4.673453e-01 | 0.330 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 4.676946e-01 | 0.330 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 4.676946e-01 | 0.330 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 4.695277e-01 | 0.328 | 0 | 0 |
| Signalling to RAS | R-HSA-167044 | 4.718989e-01 | 0.326 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 4.718989e-01 | 0.326 | 0 | 0 |
| Prevention of phagosomal-lysosomal fusion | R-HSA-9636383 | 4.718989e-01 | 0.326 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 4.731149e-01 | 0.325 | 0 | 0 |
| RNA Polymerase III Chain Elongation | R-HSA-73780 | 4.782255e-01 | 0.320 | 0 | 0 |
| STAT3 nuclear events downstream of ALK signaling | R-HSA-9701898 | 4.782255e-01 | 0.320 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 4.789390e-01 | 0.320 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 4.820463e-01 | 0.317 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 4.858926e-01 | 0.313 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 4.858926e-01 | 0.313 | 0 | 0 |
| Inactivation of CDC42 and RAC1 | R-HSA-428543 | 4.858926e-01 | 0.313 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 4.858926e-01 | 0.313 | 0 | 0 |
| CASP8 activity is inhibited | R-HSA-5218900 | 4.858926e-01 | 0.313 | 0 | 0 |
| MASTL Facilitates Mitotic Progression | R-HSA-2465910 | 4.858926e-01 | 0.313 | 0 | 0 |
| mRNA Editing | R-HSA-75072 | 4.858926e-01 | 0.313 | 0 | 0 |
| Regulation of signaling by NODAL | R-HSA-1433617 | 4.858926e-01 | 0.313 | 0 | 0 |
| Caspase activation via Dependence Receptors in the absence of ligand | R-HSA-418889 | 4.858926e-01 | 0.313 | 0 | 0 |
| Regulation of commissural axon pathfinding by SLIT and ROBO | R-HSA-428542 | 4.858926e-01 | 0.313 | 0 | 0 |
| Estrogen-stimulated signaling through PRKCZ | R-HSA-9634635 | 4.858926e-01 | 0.313 | 0 | 0 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | R-HSA-9013700 | 4.858926e-01 | 0.313 | 0 | 0 |
| Zinc influx into cells by the SLC39 gene family | R-HSA-442380 | 4.858926e-01 | 0.313 | 0 | 0 |
| Respiratory syncytial virus genome replication | R-HSA-9834752 | 4.858926e-01 | 0.313 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 4.921696e-01 | 0.308 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 4.921696e-01 | 0.308 | 0 | 0 |
| Activated NTRK3 signals through PLCG1 | R-HSA-9034793 | 4.937498e-01 | 0.306 | 0 | 0 |
| PLC-gamma1 signalling | R-HSA-167021 | 4.937498e-01 | 0.306 | 0 | 0 |
| Defective ABCC2 causes DJS | R-HSA-5679001 | 4.937498e-01 | 0.306 | 0 | 0 |
| MET activates PTPN11 | R-HSA-8865999 | 4.937498e-01 | 0.306 | 0 | 0 |
| Defective ABCA1 causes TGD | R-HSA-5682113 | 4.937498e-01 | 0.306 | 0 | 0 |
| Adrenaline signalling through Alpha-2 adrenergic receptor | R-HSA-392023 | 4.937498e-01 | 0.306 | 0 | 0 |
| Type II Na+/Pi cotransporters | R-HSA-427589 | 4.937498e-01 | 0.306 | 0 | 0 |
| Activation of BIM and translocation to mitochondria | R-HSA-111446 | 4.937498e-01 | 0.306 | 0 | 0 |
| Diseases of Mismatch Repair (MMR) | R-HSA-5423599 | 4.937498e-01 | 0.306 | 0 | 0 |
| CASP5-mediated substrate cleavage | R-HSA-9960525 | 4.937498e-01 | 0.306 | 0 | 0 |
| CASP4-mediated substrate cleavage | R-HSA-9960519 | 4.937498e-01 | 0.306 | 0 | 0 |
| NGF processing | R-HSA-167060 | 4.937498e-01 | 0.306 | 0 | 0 |
| Expression and Processing of Neurotrophins | R-HSA-9036866 | 4.937498e-01 | 0.306 | 0 | 0 |
| FasL/ CD95L signaling | R-HSA-75157 | 4.937498e-01 | 0.306 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 4.941711e-01 | 0.306 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 5.002242e-01 | 0.301 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 5.002242e-01 | 0.301 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 5.002242e-01 | 0.301 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 5.002242e-01 | 0.301 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 5.002242e-01 | 0.301 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 5.002242e-01 | 0.301 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 5.046969e-01 | 0.297 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 5.060228e-01 | 0.296 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 5.060228e-01 | 0.296 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 5.080538e-01 | 0.294 | 0 | 0 |
| Caspase activation via Death Receptors in the presence of ligand | R-HSA-140534 | 5.119740e-01 | 0.291 | 0 | 0 |
| Killing mechanisms | R-HSA-9664420 | 5.119740e-01 | 0.291 | 0 | 0 |
| WNT5:FZD7-mediated leishmania damping | R-HSA-9673324 | 5.119740e-01 | 0.291 | 0 | 0 |
| Activation of SMO | R-HSA-5635838 | 5.119740e-01 | 0.291 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 5.119740e-01 | 0.291 | 0 | 0 |
| Receptor-type tyrosine-protein phosphatases | R-HSA-388844 | 5.119740e-01 | 0.291 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 5.131243e-01 | 0.290 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 5.171559e-01 | 0.286 | 0 | 0 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 5.173814e-01 | 0.286 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 5.179073e-01 | 0.286 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 5.235748e-01 | 0.281 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 5.243933e-01 | 0.280 | 1 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 5.249742e-01 | 0.280 | 0 | 0 |
| Apoptosis induced DNA fragmentation | R-HSA-140342 | 5.281532e-01 | 0.277 | 0 | 0 |
| Defective RIPK1-mediated regulated necrosis | R-HSA-9693928 | 5.281532e-01 | 0.277 | 0 | 0 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | 5.281532e-01 | 0.277 | 0 | 0 |
| Ion influx/efflux at host-pathogen interface | R-HSA-6803544 | 5.281532e-01 | 0.277 | 0 | 0 |
| Assembly and release of respiratory syncytial virus (RSV) virions | R-HSA-9820962 | 5.281532e-01 | 0.277 | 0 | 0 |
| Tandem pore domain potassium channels | R-HSA-1296346 | 5.281532e-01 | 0.277 | 0 | 0 |
| Signaling by Leptin | R-HSA-2586552 | 5.281532e-01 | 0.277 | 0 | 0 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | R-HSA-6803205 | 5.290018e-01 | 0.277 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 5.361504e-01 | 0.271 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 5.361504e-01 | 0.271 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 5.361504e-01 | 0.271 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 5.362932e-01 | 0.271 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 5.384409e-01 | 0.269 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 5.418824e-01 | 0.266 | 0 | 0 |
| Response of Mtb to phagocytosis | R-HSA-9637690 | 5.418824e-01 | 0.266 | 0 | 0 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 5.420495e-01 | 0.266 | 0 | 0 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 5.420495e-01 | 0.266 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 5.445276e-01 | 0.264 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 5.459347e-01 | 0.263 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 5.516627e-01 | 0.258 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 5.516627e-01 | 0.258 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | R-HSA-167160 | 5.563927e-01 | 0.255 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE | R-HSA-77075 | 5.563927e-01 | 0.255 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 5.563927e-01 | 0.255 | 0 | 0 |
| Interleukin receptor SHC signaling | R-HSA-912526 | 5.563927e-01 | 0.255 | 0 | 0 |
| RUNX3 regulates BCL2L11 (BIM) transcription | R-HSA-8952158 | 5.581984e-01 | 0.253 | 0 | 0 |
| TGFBR1 KD Mutants in Cancer | R-HSA-3656532 | 5.581984e-01 | 0.253 | 0 | 0 |
| GRB7 events in ERBB2 signaling | R-HSA-1306955 | 5.581984e-01 | 0.253 | 0 | 0 |
| TNFR1-mediated ceramide production | R-HSA-5626978 | 5.581984e-01 | 0.253 | 0 | 0 |
| Transcriptional activation of cell cycle inhibitor p21 | R-HSA-69895 | 5.581984e-01 | 0.253 | 0 | 0 |
| Transcriptional activation of p53 responsive genes | R-HSA-69560 | 5.581984e-01 | 0.253 | 0 | 0 |
| SARS-CoV-1-mediated effects on programmed cell death | R-HSA-9692913 | 5.581984e-01 | 0.253 | 0 | 0 |
| Dopamine receptors | R-HSA-390651 | 5.581984e-01 | 0.253 | 0 | 0 |
| Activation of NOXA and translocation to mitochondria | R-HSA-111448 | 5.581984e-01 | 0.253 | 0 | 0 |
| Regulation of HMOX1 expression and activity | R-HSA-9707587 | 5.581984e-01 | 0.253 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 5.596676e-01 | 0.252 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 5.597475e-01 | 0.252 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 5.603904e-01 | 0.252 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 5.614874e-01 | 0.251 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 5.614874e-01 | 0.251 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 5.614874e-01 | 0.251 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 5.621659e-01 | 0.250 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 5.621659e-01 | 0.250 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 5.657291e-01 | 0.247 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 5.661088e-01 | 0.247 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 5.665808e-01 | 0.247 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 5.679893e-01 | 0.246 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 5.679893e-01 | 0.246 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 5.679893e-01 | 0.246 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 5.679893e-01 | 0.246 | 0 | 0 |
| Formation of the posterior neural plate | R-HSA-9832991 | 5.679893e-01 | 0.246 | 0 | 0 |
| Suppression of apoptosis | R-HSA-9635465 | 5.679893e-01 | 0.246 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 5.730513e-01 | 0.242 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 5.755859e-01 | 0.240 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 5.757789e-01 | 0.240 | 0 | 0 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | R-HSA-164938 | 5.757789e-01 | 0.240 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 5.779586e-01 | 0.238 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 5.820331e-01 | 0.235 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 5.820331e-01 | 0.235 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 1 | R-HSA-418592 | 5.829040e-01 | 0.234 | 0 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 5.829040e-01 | 0.234 | 0 | 0 |
| Signaling by FLT3 ITD and TKD mutants | R-HSA-9703648 | 5.829040e-01 | 0.234 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 5.830837e-01 | 0.234 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 5.848545e-01 | 0.233 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 5.946240e-01 | 0.226 | 0 | 0 |
| RAS processing | R-HSA-9648002 | 5.956637e-01 | 0.225 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 5.956637e-01 | 0.225 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 5.988467e-01 | 0.223 | 0 | 0 |
| Activated NTRK2 signals through RAS | R-HSA-9026519 | 6.053333e-01 | 0.218 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 6.053333e-01 | 0.218 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 6.053333e-01 | 0.218 | 0 | 0 |
| Sensing of DNA Double Strand Breaks | R-HSA-5693548 | 6.053333e-01 | 0.218 | 0 | 0 |
| Endosomal/Vacuolar pathway | R-HSA-1236977 | 6.053333e-01 | 0.218 | 0 | 0 |
| POLB-Dependent Long Patch Base Excision Repair | R-HSA-110362 | 6.053333e-01 | 0.218 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 6.053333e-01 | 0.218 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 6.053333e-01 | 0.218 | 0 | 0 |
| FOXO-mediated transcription of cell death genes | R-HSA-9614657 | 6.056500e-01 | 0.218 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 6.056500e-01 | 0.218 | 0 | 0 |
| Tie2 Signaling | R-HSA-210993 | 6.056500e-01 | 0.218 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 6.084753e-01 | 0.216 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 6.121883e-01 | 0.213 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 6.121883e-01 | 0.213 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 6.121883e-01 | 0.213 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 6.134630e-01 | 0.212 | 0 | 0 |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | R-HSA-3304356 | 6.144456e-01 | 0.212 | 0 | 0 |
| IRF3 mediated activation of type 1 IFN | R-HSA-1606341 | 6.144456e-01 | 0.212 | 0 | 0 |
| Resolution of AP sites via the single-nucleotide replacement pathway | R-HSA-110381 | 6.144456e-01 | 0.212 | 0 | 0 |
| Activation of AKT2 | R-HSA-165158 | 6.144456e-01 | 0.212 | 0 | 0 |
| Muscarinic acetylcholine receptors | R-HSA-390648 | 6.144456e-01 | 0.212 | 0 | 0 |
| SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | R-HSA-111464 | 6.144456e-01 | 0.212 | 0 | 0 |
| Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | R-HSA-9931529 | 6.144456e-01 | 0.212 | 0 | 0 |
| SMAC (DIABLO) binds to IAPs | R-HSA-111463 | 6.144456e-01 | 0.212 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 6.144456e-01 | 0.212 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 6.162352e-01 | 0.210 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 6.218907e-01 | 0.206 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 6.330603e-01 | 0.199 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 6.330603e-01 | 0.199 | 0 | 0 |
| Suppression of phagosomal maturation | R-HSA-9637687 | 6.330603e-01 | 0.199 | 0 | 0 |
| PI-3K cascade:FGFR3 | R-HSA-5654710 | 6.340890e-01 | 0.198 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 6.340890e-01 | 0.198 | 0 | 0 |
| Other interleukin signaling | R-HSA-449836 | 6.340890e-01 | 0.198 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 6.341239e-01 | 0.198 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 6.341239e-01 | 0.198 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 6.366101e-01 | 0.196 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 6.401741e-01 | 0.194 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 6.401741e-01 | 0.194 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 6.401741e-01 | 0.194 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 6.401741e-01 | 0.194 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 6.401741e-01 | 0.194 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 6.401741e-01 | 0.194 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 6.401741e-01 | 0.194 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 6.401741e-01 | 0.194 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 6.401741e-01 | 0.194 | 0 | 0 |
| SHC-related events triggered by IGF1R | R-HSA-2428933 | 6.401741e-01 | 0.194 | 0 | 0 |
| Role of second messengers in netrin-1 signaling | R-HSA-418890 | 6.401741e-01 | 0.194 | 0 | 0 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 6.401741e-01 | 0.194 | 0 | 0 |
| Regulation of FOXO transcriptional activity by acetylation | R-HSA-9617629 | 6.401741e-01 | 0.194 | 0 | 0 |
| Erythrocytes take up oxygen and release carbon dioxide | R-HSA-1247673 | 6.401741e-01 | 0.194 | 0 | 0 |
| Reversal of alkylation damage by DNA dioxygenases | R-HSA-73943 | 6.401741e-01 | 0.194 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 6.478833e-01 | 0.189 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 6.552812e-01 | 0.184 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 6.552812e-01 | 0.184 | 0 | 0 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | R-HSA-9615017 | 6.555438e-01 | 0.183 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 6.566253e-01 | 0.183 | 0 | 0 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 6.566253e-01 | 0.183 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 6.566253e-01 | 0.183 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 6.610663e-01 | 0.180 | 0 | 0 |
| PI-3K cascade:FGFR4 | R-HSA-5654720 | 6.610663e-01 | 0.180 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 6.610663e-01 | 0.180 | 0 | 0 |
| Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 6.610663e-01 | 0.180 | 0 | 0 |
| TYSND1 cleaves peroxisomal proteins | R-HSA-9033500 | 6.635347e-01 | 0.178 | 0 | 0 |
| Inhibition of Signaling by Overexpressed EGFR | R-HSA-5638303 | 6.635347e-01 | 0.178 | 0 | 0 |
| Signaling by Overexpressed Wild-Type EGFR in Cancer | R-HSA-5638302 | 6.635347e-01 | 0.178 | 0 | 0 |
| Loss-of-function mutations in DLD cause MSUD3/DLDD | R-HSA-9907570 | 6.635347e-01 | 0.178 | 0 | 0 |
| Signaling by MAPK mutants | R-HSA-9652817 | 6.635347e-01 | 0.178 | 0 | 0 |
| Loss-of-function mutations in DBT cause MSUD2 | R-HSA-9865113 | 6.635347e-01 | 0.178 | 0 | 0 |
| Signaling by MST1 | R-HSA-8852405 | 6.635347e-01 | 0.178 | 0 | 0 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | 6.635347e-01 | 0.178 | 0 | 0 |
| Toxicity of botulinum toxin type E (botE) | R-HSA-5250992 | 6.635347e-01 | 0.178 | 0 | 0 |
| Noncanonical activation of NOTCH3 | R-HSA-9017802 | 6.635347e-01 | 0.178 | 0 | 0 |
| PDE3B signalling | R-HSA-165160 | 6.635347e-01 | 0.178 | 0 | 0 |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | 6.635347e-01 | 0.178 | 0 | 0 |
| PKB-mediated events | R-HSA-109703 | 6.635347e-01 | 0.178 | 0 | 0 |
| Synthesis of PS | R-HSA-1483101 | 6.635347e-01 | 0.178 | 0 | 0 |
| CDC6 association with the ORC:origin complex | R-HSA-68689 | 6.635347e-01 | 0.178 | 0 | 0 |
| VEGF binds to VEGFR leading to receptor dimerization | R-HSA-195399 | 6.635347e-01 | 0.178 | 0 | 0 |
| SMAC, XIAP-regulated apoptotic response | R-HSA-111469 | 6.635347e-01 | 0.178 | 0 | 0 |
| Relaxin receptors | R-HSA-444821 | 6.635347e-01 | 0.178 | 0 | 0 |
| VEGF ligand-receptor interactions | R-HSA-194313 | 6.635347e-01 | 0.178 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 6.635347e-01 | 0.178 | 0 | 0 |
| SLC15A4:TASL-dependent IRF5 activation | R-HSA-9860276 | 6.635347e-01 | 0.178 | 0 | 0 |
| TRAIL signaling | R-HSA-75158 | 6.635347e-01 | 0.178 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 6.682372e-01 | 0.175 | 0 | 0 |
| Processing of SMDT1 | R-HSA-8949664 | 6.725437e-01 | 0.172 | 0 | 0 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 6.725437e-01 | 0.172 | 0 | 0 |
| PI5P Regulates TP53 Acetylation | R-HSA-6811555 | 6.725437e-01 | 0.172 | 0 | 0 |
| Platelet Adhesion to exposed collagen | R-HSA-75892 | 6.725437e-01 | 0.172 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | R-HSA-9029558 | 6.725437e-01 | 0.172 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 6.730981e-01 | 0.172 | 0 | 0 |
| Azathioprine ADME | R-HSA-9748787 | 6.740841e-01 | 0.171 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 6.740841e-01 | 0.171 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 6.742353e-01 | 0.171 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 6.743415e-01 | 0.171 | 0 | 0 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 6.756376e-01 | 0.170 | 0 | 0 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 6.756376e-01 | 0.170 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 6.831700e-01 | 0.165 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 6.865714e-01 | 0.163 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 6.865714e-01 | 0.163 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 6.865714e-01 | 0.163 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 6.865714e-01 | 0.163 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 6.905050e-01 | 0.161 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 6.922629e-01 | 0.160 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 6.951781e-01 | 0.158 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 6.972685e-01 | 0.157 | 0 | 0 |
| mRNA Capping | R-HSA-72086 | 7.006181e-01 | 0.155 | 0 | 0 |
| CRMPs in Sema3A signaling | R-HSA-399956 | 7.025065e-01 | 0.153 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 7.025065e-01 | 0.153 | 0 | 0 |
| TP53 Regulates Transcription of Death Receptors and Ligands | R-HSA-6803211 | 7.025065e-01 | 0.153 | 0 | 0 |
| Regulation of CDH1 mRNA translation by microRNAs | R-HSA-9764562 | 7.025065e-01 | 0.153 | 0 | 0 |
| CLEC7A (Dectin-1) induces NFAT activation | R-HSA-5607763 | 7.025065e-01 | 0.153 | 0 | 0 |
| Zinc transporters | R-HSA-435354 | 7.025065e-01 | 0.153 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 7.025065e-01 | 0.153 | 0 | 0 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | 7.063762e-01 | 0.151 | 0 | 0 |
| Autointegration results in viral DNA circles | R-HSA-177539 | 7.063762e-01 | 0.151 | 0 | 0 |
| H139Hfs13* PPM1K causes a mild variant of MSUD | R-HSA-9912529 | 7.063762e-01 | 0.151 | 0 | 0 |
| Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD | R-HSA-9865125 | 7.063762e-01 | 0.151 | 0 | 0 |
| Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | R-HSA-5619070 | 7.063762e-01 | 0.151 | 0 | 0 |
| Defective CHST14 causes EDS, musculocontractural type | R-HSA-3595174 | 7.063762e-01 | 0.151 | 0 | 0 |
| Defective CHST3 causes SEDCJD | R-HSA-3595172 | 7.063762e-01 | 0.151 | 0 | 0 |
| Branched-chain ketoacid dehydrogenase kinase deficiency | R-HSA-9912481 | 7.063762e-01 | 0.151 | 0 | 0 |
| Toxicity of botulinum toxin type D (botD) | R-HSA-5250955 | 7.063762e-01 | 0.151 | 0 | 0 |
| Toxicity of botulinum toxin type F (botF) | R-HSA-5250981 | 7.063762e-01 | 0.151 | 0 | 0 |
| Small interfering RNA (siRNA) biogenesis | R-HSA-426486 | 7.063762e-01 | 0.151 | 0 | 0 |
| Intracellular metabolism of fatty acids regulates insulin secretion | R-HSA-434313 | 7.063762e-01 | 0.151 | 0 | 0 |
| Integration of viral DNA into host genomic DNA | R-HSA-175567 | 7.063762e-01 | 0.151 | 0 | 0 |
| Abacavir transmembrane transport | R-HSA-2161517 | 7.063762e-01 | 0.151 | 0 | 0 |
| Lipid particle organization | R-HSA-8964572 | 7.063762e-01 | 0.151 | 0 | 0 |
| HDL clearance | R-HSA-8964011 | 7.063762e-01 | 0.151 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 7.071170e-01 | 0.151 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 7.096161e-01 | 0.149 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 7.106105e-01 | 0.148 | 0 | 0 |
| Ribavirin ADME | R-HSA-9755088 | 7.106105e-01 | 0.148 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 7.193215e-01 | 0.143 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 7.210317e-01 | 0.142 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 7.213392e-01 | 0.142 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 7.281674e-01 | 0.138 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 7.301505e-01 | 0.137 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 7.301505e-01 | 0.137 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 7.301505e-01 | 0.137 | 0 | 0 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 7.301505e-01 | 0.137 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 7.301505e-01 | 0.137 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 7.301505e-01 | 0.137 | 0 | 0 |
| Biotin transport and metabolism | R-HSA-196780 | 7.301505e-01 | 0.137 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 7.301505e-01 | 0.137 | 0 | 0 |
| Formation of the anterior neural plate | R-HSA-9823739 | 7.301505e-01 | 0.137 | 0 | 0 |
| DNA Damage Reversal | R-HSA-73942 | 7.301505e-01 | 0.137 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 7.310455e-01 | 0.136 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 7.317194e-01 | 0.136 | 0 | 0 |
| PI-3K cascade:FGFR1 | R-HSA-5654689 | 7.332031e-01 | 0.135 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 7.422775e-01 | 0.129 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 7.422775e-01 | 0.129 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 7.425200e-01 | 0.129 | 0 | 0 |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | R-HSA-159782 | 7.437649e-01 | 0.129 | 0 | 0 |
| Activated NTRK2 signals through CDK5 | R-HSA-9032845 | 7.437649e-01 | 0.129 | 0 | 0 |
| Defective CHSY1 causes TPBS | R-HSA-3595177 | 7.437649e-01 | 0.129 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 7.437649e-01 | 0.129 | 0 | 0 |
| Insulin effects increased synthesis of Xylulose-5-Phosphate | R-HSA-163754 | 7.437649e-01 | 0.129 | 0 | 0 |
| PTK6 Expression | R-HSA-8849473 | 7.437649e-01 | 0.129 | 0 | 0 |
| VLDL clearance | R-HSA-8964046 | 7.437649e-01 | 0.129 | 0 | 0 |
| Cation-coupled Chloride cotransporters | R-HSA-426117 | 7.437649e-01 | 0.129 | 0 | 0 |
| Netrin mediated repulsion signals | R-HSA-418886 | 7.437649e-01 | 0.129 | 0 | 0 |
| Biosynthesis of maresin conjugates in tissue regeneration (MCTR) | R-HSA-9026762 | 7.437649e-01 | 0.129 | 0 | 0 |
| Defective HLCS causes multiple carboxylase deficiency | R-HSA-3371599 | 7.437649e-01 | 0.129 | 0 | 0 |
| CHL1 interactions | R-HSA-447041 | 7.437649e-01 | 0.129 | 0 | 0 |
| Nef Mediated CD4 Down-regulation | R-HSA-167590 | 7.437649e-01 | 0.129 | 0 | 0 |
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 7.437649e-01 | 0.129 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 7.488418e-01 | 0.126 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 7.527841e-01 | 0.123 | 0 | 0 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | R-HSA-399955 | 7.555803e-01 | 0.122 | 0 | 0 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 7.555803e-01 | 0.122 | 0 | 0 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | R-HSA-6803207 | 7.555803e-01 | 0.122 | 0 | 0 |
| Phase 4 - resting membrane potential | R-HSA-5576886 | 7.555803e-01 | 0.122 | 0 | 0 |
| Atorvastatin ADME | R-HSA-9754706 | 7.555803e-01 | 0.122 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 7.575843e-01 | 0.121 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 7.587205e-01 | 0.120 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 7.650833e-01 | 0.116 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 7.650833e-01 | 0.116 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 7.682436e-01 | 0.115 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 7.722133e-01 | 0.112 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 7.722133e-01 | 0.112 | 0 | 0 |
| Translocation of ZAP-70 to Immunological synapse | R-HSA-202430 | 7.741804e-01 | 0.111 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 7.746658e-01 | 0.111 | 0 | 0 |
| G-protein beta:gamma signalling | R-HSA-397795 | 7.760266e-01 | 0.110 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 7.763946e-01 | 0.110 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 7.763946e-01 | 0.110 | 0 | 0 |
| Axonal growth inhibition (RHOA activation) | R-HSA-193634 | 7.763946e-01 | 0.110 | 0 | 0 |
| Regulation of NPAS4 mRNA translation | R-HSA-9768778 | 7.763946e-01 | 0.110 | 0 | 0 |
| Activation of RAS in B cells | R-HSA-1169092 | 7.763946e-01 | 0.110 | 0 | 0 |
| TGFBR3 PTM regulation | R-HSA-9839383 | 7.763946e-01 | 0.110 | 0 | 0 |
| Sodium/Proton exchangers | R-HSA-425986 | 7.763946e-01 | 0.110 | 0 | 0 |
| Negative regulation of activity of TFAP2 (AP-2) family transcription factors | R-HSA-8866904 | 7.763946e-01 | 0.110 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 7.763946e-01 | 0.110 | 0 | 0 |
| Antigen processing: Ub, ATP-independent proteasomal degradation | R-HSA-9912633 | 7.789116e-01 | 0.109 | 0 | 0 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | R-HSA-4420332 | 7.789116e-01 | 0.109 | 0 | 0 |
| Defective B4GALT7 causes EDS, progeroid type | R-HSA-3560783 | 7.789116e-01 | 0.109 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 7.789116e-01 | 0.109 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 7.789116e-01 | 0.109 | 0 | 0 |
| STAT5 activation downstream of FLT3 ITD mutants | R-HSA-9702518 | 7.789116e-01 | 0.109 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | R-HSA-2892247 | 7.789116e-01 | 0.109 | 0 | 0 |
| Response to metal ions | R-HSA-5660526 | 7.789116e-01 | 0.109 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 7.817935e-01 | 0.107 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 7.905633e-01 | 0.102 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 7.911977e-01 | 0.102 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 7.923369e-01 | 0.101 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 7.923369e-01 | 0.101 | 0 | 0 |
| PI-3K cascade:FGFR2 | R-HSA-5654695 | 7.926517e-01 | 0.101 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 7.926517e-01 | 0.101 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 7.926517e-01 | 0.101 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 7.951536e-01 | 0.100 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 7.951536e-01 | 0.100 | 0 | 0 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 8.002663e-01 | 0.097 | 0 | 0 |
| Defective B3GAT3 causes JDSSDHD | R-HSA-3560801 | 8.002663e-01 | 0.097 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 8.002663e-01 | 0.097 | 0 | 0 |
| Synthesis of PIPs at the late endosome membrane | R-HSA-1660517 | 8.002663e-01 | 0.097 | 0 | 0 |
| Specification of primordial germ cells | R-HSA-9827857 | 8.002663e-01 | 0.097 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 8.043155e-01 | 0.095 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 8.043155e-01 | 0.095 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 8.045263e-01 | 0.094 | 0 | 0 |
| MAPK1 (ERK2) activation | R-HSA-112411 | 8.048708e-01 | 0.094 | 0 | 0 |
| AMPK inhibits chREBP transcriptional activation activity | R-HSA-163680 | 8.048708e-01 | 0.094 | 0 | 0 |
| Hypusine synthesis from eIF5A-lysine | R-HSA-204626 | 8.048708e-01 | 0.094 | 0 | 0 |
| Toxicity of botulinum toxin type A (botA) | R-HSA-5250968 | 8.048708e-01 | 0.094 | 0 | 0 |
| APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway | R-HSA-5649702 | 8.048708e-01 | 0.094 | 0 | 0 |
| p75NTR regulates axonogenesis | R-HSA-193697 | 8.048708e-01 | 0.094 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 8.048708e-01 | 0.094 | 0 | 0 |
| Activation of the TFAP2 (AP-2) family of transcription factors | R-HSA-8866907 | 8.048708e-01 | 0.094 | 0 | 0 |
| Interleukin-1 processing | R-HSA-448706 | 8.048708e-01 | 0.094 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 8.048708e-01 | 0.094 | 0 | 0 |
| Defects in biotin (Btn) metabolism | R-HSA-3323169 | 8.048708e-01 | 0.094 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 8.076790e-01 | 0.093 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 8.098456e-01 | 0.092 | 0 | 0 |
| Synthesis of IP2, IP, and Ins in the cytosol | R-HSA-1855183 | 8.098456e-01 | 0.092 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 8.112766e-01 | 0.091 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 8.154817e-01 | 0.089 | 0 | 0 |
| Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 8.197693e-01 | 0.086 | 0 | 0 |
| Cytosolic iron-sulfur cluster assembly | R-HSA-2564830 | 8.197693e-01 | 0.086 | 0 | 0 |
| PKA activation | R-HSA-163615 | 8.197693e-01 | 0.086 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 8.255106e-01 | 0.083 | 0 | 0 |
| Signaling by BMP | R-HSA-201451 | 8.258181e-01 | 0.083 | 0 | 0 |
| Maturation of hRSV A proteins | R-HSA-9828806 | 8.258181e-01 | 0.083 | 0 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 8.291652e-01 | 0.081 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 8.291903e-01 | 0.081 | 0 | 0 |
| Folding of actin by CCT/TriC | R-HSA-390450 | 8.297220e-01 | 0.081 | 0 | 0 |
| Binding and entry of HIV virion | R-HSA-173107 | 8.297220e-01 | 0.081 | 0 | 0 |
| MAPK3 (ERK1) activation | R-HSA-110056 | 8.297220e-01 | 0.081 | 0 | 0 |
| DNA replication initiation | R-HSA-68952 | 8.297220e-01 | 0.081 | 0 | 0 |
| Metal sequestration by antimicrobial proteins | R-HSA-6799990 | 8.297220e-01 | 0.081 | 0 | 0 |
| Peptide hormone biosynthesis | R-HSA-209952 | 8.297220e-01 | 0.081 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 8.313962e-01 | 0.080 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 8.356312e-01 | 0.078 | 0 | 0 |
| Germ layer formation at gastrulation | R-HSA-9754189 | 8.375459e-01 | 0.077 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 8.375459e-01 | 0.077 | 0 | 0 |
| Erythrocytes take up carbon dioxide and release oxygen | R-HSA-1237044 | 8.375459e-01 | 0.077 | 0 | 0 |
| O2/CO2 exchange in erythrocytes | R-HSA-1480926 | 8.375459e-01 | 0.077 | 0 | 0 |
| E2F mediated regulation of DNA replication | R-HSA-113510 | 8.375459e-01 | 0.077 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 8.375459e-01 | 0.077 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 8.406277e-01 | 0.075 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 8.434090e-01 | 0.074 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 8.463185e-01 | 0.072 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 8.497075e-01 | 0.071 | 0 | 0 |
| Presynaptic depolarization and calcium channel opening | R-HSA-112308 | 8.514095e-01 | 0.070 | 0 | 0 |
| vRNP Assembly | R-HSA-192905 | 8.514095e-01 | 0.070 | 0 | 0 |
| RHOBTB3 ATPase cycle | R-HSA-9706019 | 8.514095e-01 | 0.070 | 0 | 0 |
| Synthesis of PI | R-HSA-1483226 | 8.514095e-01 | 0.070 | 0 | 0 |
| Activated NTRK3 signals through RAS | R-HSA-9034864 | 8.514095e-01 | 0.070 | 0 | 0 |
| Transport of RCbl within the body | R-HSA-9758890 | 8.514095e-01 | 0.070 | 0 | 0 |
| Synthesis of PIPs at the ER membrane | R-HSA-1483248 | 8.514095e-01 | 0.070 | 0 | 0 |
| Prostanoid ligand receptors | R-HSA-391908 | 8.514095e-01 | 0.070 | 0 | 0 |
| Interleukin-2 signaling | R-HSA-9020558 | 8.514095e-01 | 0.070 | 0 | 0 |
| Dissolution of Fibrin Clot | R-HSA-75205 | 8.514095e-01 | 0.070 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 8.537194e-01 | 0.069 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 8.543346e-01 | 0.068 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 8.543346e-01 | 0.068 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 8.543346e-01 | 0.068 | 0 | 0 |
| Regulation of pyruvate metabolism | R-HSA-9861718 | 8.571043e-01 | 0.067 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 8.600203e-01 | 0.065 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 8.631797e-01 | 0.064 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 8.661709e-01 | 0.062 | 0 | 0 |
| NOTCH3 Intracellular Domain Regulates Transcription | R-HSA-9013508 | 8.669994e-01 | 0.062 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 8.669994e-01 | 0.062 | 0 | 0 |
| Synthesis of PC | R-HSA-1483191 | 8.674102e-01 | 0.062 | 0 | 0 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 8.684097e-01 | 0.061 | 0 | 0 |
| DS-GAG biosynthesis | R-HSA-2022923 | 8.703358e-01 | 0.060 | 0 | 0 |
| Synthesis of diphthamide-EEF2 | R-HSA-5358493 | 8.703358e-01 | 0.060 | 0 | 0 |
| PI3K events in ERBB4 signaling | R-HSA-1250342 | 8.703358e-01 | 0.060 | 0 | 0 |
| Proton-coupled monocarboxylate transport | R-HSA-433692 | 8.703358e-01 | 0.060 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 8.703358e-01 | 0.060 | 0 | 0 |
| NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | R-HSA-9623433 | 8.703358e-01 | 0.060 | 0 | 0 |
| Reduction of cytosolic Ca++ levels | R-HSA-418359 | 8.703358e-01 | 0.060 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 8.703358e-01 | 0.060 | 0 | 0 |
| Sodium/Calcium exchangers | R-HSA-425561 | 8.703358e-01 | 0.060 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 8.710291e-01 | 0.060 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 8.710291e-01 | 0.060 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 8.770817e-01 | 0.057 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 8.812831e-01 | 0.055 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 8.817322e-01 | 0.055 | 0 | 0 |
| FOXO-mediated transcription of cell cycle genes | R-HSA-9617828 | 8.817322e-01 | 0.055 | 0 | 0 |
| FRS-mediated FGFR3 signaling | R-HSA-5654706 | 8.817322e-01 | 0.055 | 0 | 0 |
| Serine metabolism | R-HSA-977347 | 8.817322e-01 | 0.055 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 8.830780e-01 | 0.054 | 0 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 8.838443e-01 | 0.054 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 8.841386e-01 | 0.053 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 8.857887e-01 | 0.053 | 0 | 0 |
| Maple Syrup Urine Disease | R-HSA-9865114 | 8.868524e-01 | 0.052 | 0 | 0 |
| Defective EXT2 causes exostoses 2 | R-HSA-3656237 | 8.868524e-01 | 0.052 | 0 | 0 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | R-HSA-3656253 | 8.868524e-01 | 0.052 | 0 | 0 |
| RUNX3 regulates p14-ARF | R-HSA-8951936 | 8.868524e-01 | 0.052 | 0 | 0 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | 8.868524e-01 | 0.052 | 0 | 0 |
| Serotonin clearance from the synaptic cleft | R-HSA-380615 | 8.868524e-01 | 0.052 | 0 | 0 |
| Regulation of IFNG signaling | R-HSA-877312 | 8.868524e-01 | 0.052 | 0 | 0 |
| Trafficking and processing of endosomal TLR | R-HSA-1679131 | 8.868524e-01 | 0.052 | 0 | 0 |
| Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | R-HSA-159854 | 8.868524e-01 | 0.052 | 0 | 0 |
| MET activates RAS signaling | R-HSA-8851805 | 8.868524e-01 | 0.052 | 0 | 0 |
| Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | R-HSA-9931530 | 8.868524e-01 | 0.052 | 0 | 0 |
| Diseases associated with surfactant metabolism | R-HSA-5687613 | 8.868524e-01 | 0.052 | 0 | 0 |
| Interleukin-15 signaling | R-HSA-8983432 | 8.868524e-01 | 0.052 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 8.868524e-01 | 0.052 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 8.893694e-01 | 0.051 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 8.894441e-01 | 0.051 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 8.896439e-01 | 0.051 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 8.897974e-01 | 0.051 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 8.906120e-01 | 0.050 | 0 | 0 |
| Regulation of IFNA/IFNB signaling | R-HSA-912694 | 8.937968e-01 | 0.049 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 8.937968e-01 | 0.049 | 0 | 0 |
| RAF-independent MAPK1/3 activation | R-HSA-112409 | 8.937968e-01 | 0.049 | 0 | 0 |
| FRS-mediated FGFR4 signaling | R-HSA-5654712 | 8.937968e-01 | 0.049 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 8.954468e-01 | 0.048 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 8.965915e-01 | 0.047 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 8.992643e-01 | 0.046 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 8.996799e-01 | 0.046 | 0 | 0 |
| Reversible hydration of carbon dioxide | R-HSA-1475029 | 9.012659e-01 | 0.045 | 0 | 0 |
| NFE2L2 regulating tumorigenic genes | R-HSA-9818030 | 9.012659e-01 | 0.045 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9683610 | 9.012659e-01 | 0.045 | 0 | 0 |
| Interleukin-6 signaling | R-HSA-1059683 | 9.012659e-01 | 0.045 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 9.029083e-01 | 0.044 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 9.044578e-01 | 0.044 | 0 | 0 |
| Free fatty acids regulate insulin secretion | R-HSA-400451 | 9.047078e-01 | 0.043 | 0 | 0 |
| ABC transporters in lipid homeostasis | R-HSA-1369062 | 9.047078e-01 | 0.043 | 0 | 0 |
| Synthesis of pyrophosphates in the cytosol | R-HSA-1855167 | 9.047078e-01 | 0.043 | 0 | 0 |
| Carnitine shuttle | R-HSA-200425 | 9.047078e-01 | 0.043 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 9.054954e-01 | 0.043 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 9.099688e-01 | 0.041 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 9.101350e-01 | 0.041 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 9.108085e-01 | 0.041 | 0 | 0 |
| Removal of the Flap Intermediate | R-HSA-69166 | 9.138441e-01 | 0.039 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR3 | R-HSA-5654227 | 9.138441e-01 | 0.039 | 0 | 0 |
| BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV | R-HSA-9859138 | 9.138441e-01 | 0.039 | 0 | 0 |
| HDL assembly | R-HSA-8963896 | 9.138441e-01 | 0.039 | 0 | 0 |
| Synthesis of IPs in the nucleus | R-HSA-1855191 | 9.138441e-01 | 0.039 | 0 | 0 |
| Hydrolysis of LPC | R-HSA-1483115 | 9.138441e-01 | 0.039 | 0 | 0 |
| cGMP effects | R-HSA-418457 | 9.138441e-01 | 0.039 | 0 | 0 |
| Glycerophospholipid catabolism | R-HSA-6814848 | 9.138441e-01 | 0.039 | 0 | 0 |
| Non-canonical inflammasome activation | R-HSA-9686114 | 9.138441e-01 | 0.039 | 0 | 0 |
| Acyl chain remodeling of CL | R-HSA-1482798 | 9.138441e-01 | 0.039 | 0 | 0 |
| P2Y receptors | R-HSA-417957 | 9.138441e-01 | 0.039 | 0 | 0 |
| Assembly of active LPL and LIPC lipase complexes | R-HSA-8963889 | 9.145633e-01 | 0.039 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 9.167750e-01 | 0.038 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 9.167750e-01 | 0.038 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 9.169052e-01 | 0.038 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 9.173279e-01 | 0.037 | 0 | 0 |
| Immune System | R-HSA-168256 | 9.190956e-01 | 0.037 | 0 | 0 |
| Surfactant metabolism | R-HSA-5683826 | 9.225610e-01 | 0.035 | 0 | 0 |
| Amine ligand-binding receptors | R-HSA-375280 | 9.225610e-01 | 0.035 | 0 | 0 |
| FRS-mediated FGFR1 signaling | R-HSA-5654693 | 9.234551e-01 | 0.035 | 0 | 0 |
| MicroRNA (miRNA) biogenesis | R-HSA-203927 | 9.234551e-01 | 0.035 | 0 | 0 |
| Laminin interactions | R-HSA-3000157 | 9.234551e-01 | 0.035 | 0 | 0 |
| Hyaluronan degradation | R-HSA-2160916 | 9.234551e-01 | 0.035 | 0 | 0 |
| Synthesis of PIPs at the early endosome membrane | R-HSA-1660516 | 9.234551e-01 | 0.035 | 0 | 0 |
| PIWI-interacting RNA (piRNA) biogenesis | R-HSA-5601884 | 9.234551e-01 | 0.035 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 9.243705e-01 | 0.034 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR4 | R-HSA-5654228 | 9.248206e-01 | 0.034 | 0 | 0 |
| G beta:gamma signalling through BTK | R-HSA-8964315 | 9.248206e-01 | 0.034 | 0 | 0 |
| Telomere C-strand synthesis initiation | R-HSA-174430 | 9.248206e-01 | 0.034 | 0 | 0 |
| Protein repair | R-HSA-5676934 | 9.248206e-01 | 0.034 | 0 | 0 |
| Protein lipoylation | R-HSA-9857492 | 9.248206e-01 | 0.034 | 0 | 0 |
| Other semaphorin interactions | R-HSA-416700 | 9.248206e-01 | 0.034 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 9.290755e-01 | 0.032 | 0 | 0 |
| Influenza Infection | R-HSA-168255 | 9.313248e-01 | 0.031 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 9.314104e-01 | 0.031 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 9.314104e-01 | 0.031 | 0 | 0 |
| MET activates PTK2 signaling | R-HSA-8874081 | 9.314687e-01 | 0.031 | 0 | 0 |
| Sphingolipid catabolism | R-HSA-9845614 | 9.314687e-01 | 0.031 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 9.314687e-01 | 0.031 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 9.340350e-01 | 0.030 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 9.343991e-01 | 0.029 | 0 | 0 |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | R-HSA-434316 | 9.343991e-01 | 0.029 | 0 | 0 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | R-HSA-210744 | 9.343991e-01 | 0.029 | 0 | 0 |
| Fructose catabolism | R-HSA-70350 | 9.343991e-01 | 0.029 | 0 | 0 |
| Induction of Cell-Cell Fusion | R-HSA-9733458 | 9.343991e-01 | 0.029 | 0 | 0 |
| Attachment and Entry | R-HSA-9678110 | 9.343991e-01 | 0.029 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 9.348739e-01 | 0.029 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 9.349412e-01 | 0.029 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.360568e-01 | 0.029 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 9.386835e-01 | 0.027 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 9.386835e-01 | 0.027 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 9.386835e-01 | 0.027 | 0 | 0 |
| G beta:gamma signalling through CDC42 | R-HSA-8964616 | 9.427578e-01 | 0.026 | 0 | 0 |
| Phase 2 - plateau phase | R-HSA-5576893 | 9.427578e-01 | 0.026 | 0 | 0 |
| Fibronectin matrix formation | R-HSA-1566977 | 9.427578e-01 | 0.026 | 0 | 0 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 9.427578e-01 | 0.026 | 0 | 0 |
| Heme assimilation | R-HSA-9927020 | 9.427578e-01 | 0.026 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 9.427578e-01 | 0.026 | 0 | 0 |
| SHC1 events in ERBB4 signaling | R-HSA-1250347 | 9.427578e-01 | 0.026 | 0 | 0 |
| tRNA modification in the mitochondrion | R-HSA-6787450 | 9.427578e-01 | 0.026 | 0 | 0 |
| Synthesis of PG | R-HSA-1483148 | 9.427578e-01 | 0.026 | 0 | 0 |
| ATF4 activates genes in response to endoplasmic reticulum stress | R-HSA-380994 | 9.451728e-01 | 0.024 | 0 | 0 |
| FRS-mediated FGFR2 signaling | R-HSA-5654700 | 9.451728e-01 | 0.024 | 0 | 0 |
| Insulin receptor recycling | R-HSA-77387 | 9.451728e-01 | 0.024 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 9.451728e-01 | 0.024 | 0 | 0 |
| Pyrimidine salvage | R-HSA-73614 | 9.451728e-01 | 0.024 | 0 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 9.465803e-01 | 0.024 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 9.468701e-01 | 0.024 | 0 | 0 |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | R-HSA-381771 | 9.489667e-01 | 0.023 | 0 | 0 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 9.500518e-01 | 0.022 | 0 | 0 |
| Uptake and function of anthrax toxins | R-HSA-5210891 | 9.500518e-01 | 0.022 | 0 | 0 |
| Regulation of NPAS4 gene expression | R-HSA-9768759 | 9.500518e-01 | 0.022 | 0 | 0 |
| Nitric oxide stimulates guanylate cyclase | R-HSA-392154 | 9.510045e-01 | 0.022 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.533352e-01 | 0.021 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 9.534190e-01 | 0.021 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 9.562407e-01 | 0.019 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 9.564168e-01 | 0.019 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 9.564168e-01 | 0.019 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 9.564168e-01 | 0.019 | 0 | 0 |
| Organic anion transport by SLC5/17/25 transporters | R-HSA-428643 | 9.564168e-01 | 0.019 | 0 | 0 |
| Biosynthesis of DHA-derived sulfido conjugates | R-HSA-9026395 | 9.564168e-01 | 0.019 | 0 | 0 |
| Nucleotide-like (purinergic) receptors | R-HSA-418038 | 9.564168e-01 | 0.019 | 0 | 0 |
| Vitamin D (calciferol) metabolism | R-HSA-196791 | 9.564168e-01 | 0.019 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9679504 | 9.564168e-01 | 0.019 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 9.582389e-01 | 0.019 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 9.592415e-01 | 0.018 | 0 | 0 |
| Cargo concentration in the ER | R-HSA-5694530 | 9.609384e-01 | 0.017 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 9.618083e-01 | 0.017 | 0 | 0 |
| Pyrimidine biosynthesis | R-HSA-500753 | 9.619710e-01 | 0.017 | 0 | 0 |
| Pre-NOTCH Processing in Golgi | R-HSA-1912420 | 9.619710e-01 | 0.017 | 0 | 0 |
| Specification of the neural plate border | R-HSA-9834899 | 9.619710e-01 | 0.017 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 9.635177e-01 | 0.016 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 9.636577e-01 | 0.016 | 0 | 0 |
| Developmental Lineage of Multipotent Pancreatic Progenitor Cells | R-HSA-9937080 | 9.651498e-01 | 0.015 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 9.657656e-01 | 0.015 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 9.657666e-01 | 0.015 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 9.659122e-01 | 0.015 | 0 | 0 |
| Incretin synthesis, secretion, and inactivation | R-HSA-400508 | 9.659122e-01 | 0.015 | 0 | 0 |
| Phospholipase C-mediated cascade; FGFR2 | R-HSA-5654221 | 9.668176e-01 | 0.015 | 0 | 0 |
| Formation of ATP by chemiosmotic coupling | R-HSA-163210 | 9.668176e-01 | 0.015 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 9.668176e-01 | 0.015 | 0 | 0 |
| Acyl chain remodelling of PI | R-HSA-1482922 | 9.668176e-01 | 0.015 | 0 | 0 |
| Eicosanoid ligand-binding receptors | R-HSA-391903 | 9.668176e-01 | 0.015 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 9.685556e-01 | 0.014 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 9.689552e-01 | 0.014 | 0 | 0 |
| Synthesis of very long-chain fatty acyl-CoAs | R-HSA-75876 | 9.692301e-01 | 0.014 | 0 | 0 |
| G-protein activation | R-HSA-202040 | 9.710469e-01 | 0.013 | 0 | 0 |
| Matriglycan biosynthesis on DAG1 | R-HSA-9939291 | 9.710469e-01 | 0.013 | 0 | 0 |
| SHC-mediated cascade:FGFR3 | R-HSA-5654704 | 9.710469e-01 | 0.013 | 0 | 0 |
| Synthesis, secretion, and deacylation of Ghrelin | R-HSA-422085 | 9.710469e-01 | 0.013 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 9.710469e-01 | 0.013 | 0 | 0 |
| Vitamin C (ascorbate) metabolism | R-HSA-196836 | 9.710469e-01 | 0.013 | 0 | 0 |
| Acyl chain remodelling of PG | R-HSA-1482925 | 9.710469e-01 | 0.013 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 9.711751e-01 | 0.013 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 9.723000e-01 | 0.012 | 0 | 0 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 9.723000e-01 | 0.012 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 9.723000e-01 | 0.012 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 9.729040e-01 | 0.012 | 0 | 0 |
| CS-GAG biosynthesis | R-HSA-2022870 | 9.747373e-01 | 0.011 | 0 | 0 |
| Androgen biosynthesis | R-HSA-193048 | 9.747373e-01 | 0.011 | 0 | 0 |
| SHC-mediated cascade:FGFR4 | R-HSA-5654719 | 9.747373e-01 | 0.011 | 0 | 0 |
| Glucocorticoid biosynthesis | R-HSA-194002 | 9.747373e-01 | 0.011 | 0 | 0 |
| Glycosaminoglycan-protein linkage region biosynthesis | R-HSA-1971475 | 9.753216e-01 | 0.011 | 0 | 0 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | R-HSA-6814122 | 9.753216e-01 | 0.011 | 0 | 0 |
| Hyaluronan metabolism | R-HSA-2142845 | 9.753216e-01 | 0.011 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 9.754316e-01 | 0.011 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 9.773337e-01 | 0.010 | 0 | 0 |
| Neurotoxicity of clostridium toxins | R-HSA-168799 | 9.779575e-01 | 0.010 | 0 | 0 |
| Fructose metabolism | R-HSA-5652084 | 9.779575e-01 | 0.010 | 0 | 0 |
| Ethanol oxidation | R-HSA-71384 | 9.779575e-01 | 0.010 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9694676 | 9.779575e-01 | 0.010 | 0 | 0 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 9.780233e-01 | 0.010 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 9.780233e-01 | 0.010 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 9.787204e-01 | 0.009 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 9.802893e-01 | 0.009 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 9.804373e-01 | 0.009 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 9.806825e-01 | 0.008 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 9.806825e-01 | 0.008 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 9.806825e-01 | 0.008 | 0 | 0 |
| Formation of the ureteric bud | R-HSA-9830674 | 9.807674e-01 | 0.008 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 9.807674e-01 | 0.008 | 0 | 0 |
| Interferon alpha/beta signaling | R-HSA-909733 | 9.808789e-01 | 0.008 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 9.810494e-01 | 0.008 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 9.817104e-01 | 0.008 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 9.822572e-01 | 0.008 | 0 | 0 |
| Glutathione conjugation | R-HSA-156590 | 9.824727e-01 | 0.008 | 0 | 0 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 9.825932e-01 | 0.008 | 0 | 0 |
| Metabolism of folate and pterines | R-HSA-196757 | 9.825932e-01 | 0.008 | 0 | 0 |
| Translation | R-HSA-72766 | 9.828310e-01 | 0.008 | 0 | 0 |
| Complex III assembly | R-HSA-9865881 | 9.832192e-01 | 0.007 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 9.832192e-01 | 0.007 | 0 | 0 |
| SHC-mediated cascade:FGFR1 | R-HSA-5654688 | 9.832192e-01 | 0.007 | 0 | 0 |
| TNFs bind their physiological receptors | R-HSA-5669034 | 9.832192e-01 | 0.007 | 0 | 0 |
| Thromboxane signalling through TP receptor | R-HSA-428930 | 9.832192e-01 | 0.007 | 0 | 0 |
| Mitochondrial RNA degradation | R-HSA-9836573 | 9.832192e-01 | 0.007 | 0 | 0 |
| Interleukin-6 family signaling | R-HSA-6783589 | 9.832192e-01 | 0.007 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 9.836640e-01 | 0.007 | 0 | 0 |
| Interconversion of nucleotide di- and triphosphates | R-HSA-499943 | 9.839200e-01 | 0.007 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 9.841050e-01 | 0.007 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 9.849663e-01 | 0.007 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 9.853350e-01 | 0.006 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 9.854065e-01 | 0.006 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 9.855925e-01 | 0.006 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 9.856370e-01 | 0.006 | 0 | 0 |
| Cytosolic sulfonation of small molecules | R-HSA-156584 | 9.866938e-01 | 0.006 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 9.867721e-01 | 0.006 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 9.867721e-01 | 0.006 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.867721e-01 | 0.006 | 0 | 0 |
| Diseases of branched-chain amino acid catabolism | R-HSA-9865118 | 9.872253e-01 | 0.006 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 9.872253e-01 | 0.006 | 0 | 0 |
| Urea cycle | R-HSA-70635 | 9.872253e-01 | 0.006 | 0 | 0 |
| Linoleic acid (LA) metabolism | R-HSA-2046105 | 9.872253e-01 | 0.006 | 0 | 0 |
| Abacavir ADME | R-HSA-2161522 | 9.872253e-01 | 0.006 | 0 | 0 |
| Mitochondrial tRNA aminoacylation | R-HSA-379726 | 9.877650e-01 | 0.005 | 0 | 0 |
| Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane | R-HSA-83936 | 9.888542e-01 | 0.005 | 0 | 0 |
| SHC-mediated cascade:FGFR2 | R-HSA-5654699 | 9.888542e-01 | 0.005 | 0 | 0 |
| Triglyceride biosynthesis | R-HSA-75109 | 9.888542e-01 | 0.005 | 0 | 0 |
| Synthesis of PE | R-HSA-1483213 | 9.888542e-01 | 0.005 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 9.888542e-01 | 0.005 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 9.889901e-01 | 0.005 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 9.898918e-01 | 0.004 | 0 | 0 |
| Prednisone ADME | R-HSA-9757110 | 9.902754e-01 | 0.004 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 9.902754e-01 | 0.004 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 9.905602e-01 | 0.004 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 9.910728e-01 | 0.004 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 9.912460e-01 | 0.004 | 0 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 9.913082e-01 | 0.004 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 9.913470e-01 | 0.004 | 0 | 0 |
| Paracetamol ADME | R-HSA-9753281 | 9.913470e-01 | 0.004 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 9.914271e-01 | 0.004 | 0 | 0 |
| Glucagon-type ligand receptors | R-HSA-420092 | 9.915155e-01 | 0.004 | 0 | 0 |
| Activation of Matrix Metalloproteinases | R-HSA-1592389 | 9.915155e-01 | 0.004 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 9.922852e-01 | 0.003 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 9.925975e-01 | 0.003 | 0 | 0 |
| Neurotransmitter clearance | R-HSA-112311 | 9.925975e-01 | 0.003 | 0 | 0 |
| Methylation | R-HSA-156581 | 9.932476e-01 | 0.003 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 9.933907e-01 | 0.003 | 0 | 0 |
| Diseases associated with glycosaminoglycan metabolism | R-HSA-3560782 | 9.940099e-01 | 0.003 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 9.940099e-01 | 0.003 | 0 | 0 |
| HS-GAG degradation | R-HSA-2024096 | 9.943653e-01 | 0.002 | 0 | 0 |
| DAG1 glycosylations | R-HSA-8931838 | 9.943653e-01 | 0.002 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 9.949919e-01 | 0.002 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.951231e-01 | 0.002 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 9.952527e-01 | 0.002 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 9.957092e-01 | 0.002 | 0 | 0 |
| CS/DS degradation | R-HSA-2024101 | 9.957111e-01 | 0.002 | 0 | 0 |
| Vitamin B5 (pantothenate) metabolism | R-HSA-199220 | 9.957111e-01 | 0.002 | 0 | 0 |
| Heme degradation | R-HSA-189483 | 9.957111e-01 | 0.002 | 0 | 0 |
| Plasma lipoprotein remodeling | R-HSA-8963899 | 9.958253e-01 | 0.002 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 9.961407e-01 | 0.002 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 9.961458e-01 | 0.002 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 9.962582e-01 | 0.002 | 0 | 0 |
| Regulation of TLR by endogenous ligand | R-HSA-5686938 | 9.962582e-01 | 0.002 | 0 | 0 |
| Glyoxylate metabolism and glycine degradation | R-HSA-389661 | 9.963006e-01 | 0.002 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.963006e-01 | 0.002 | 0 | 0 |
| Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 9.963136e-01 | 0.002 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 9.963136e-01 | 0.002 | 0 | 0 |
| Defects in vitamin and cofactor metabolism | R-HSA-3296482 | 9.967356e-01 | 0.001 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 9.969467e-01 | 0.001 | 0 | 0 |
| HS-GAG biosynthesis | R-HSA-2022928 | 9.971520e-01 | 0.001 | 0 | 0 |
| Triglyceride catabolism | R-HSA-163560 | 9.971520e-01 | 0.001 | 0 | 0 |
| NCAM1 interactions | R-HSA-419037 | 9.975154e-01 | 0.001 | 0 | 0 |
| Collagen chain trimerization | R-HSA-8948216 | 9.975154e-01 | 0.001 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 9.977045e-01 | 0.001 | 0 | 0 |
| Nucleotide biosynthesis | R-HSA-8956320 | 9.977244e-01 | 0.001 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.977981e-01 | 0.001 | 0 | 0 |
| tRNA processing in the mitochondrion | R-HSA-6785470 | 9.978324e-01 | 0.001 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 9.978324e-01 | 0.001 | 0 | 0 |
| Purine salvage | R-HSA-74217 | 9.978324e-01 | 0.001 | 0 | 0 |
| alpha-linolenic acid (ALA) metabolism | R-HSA-2046106 | 9.978324e-01 | 0.001 | 0 | 0 |
| Mitochondrial ribosome-associated quality control | R-HSA-9937383 | 9.981054e-01 | 0.001 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 9.981054e-01 | 0.001 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 9.981090e-01 | 0.001 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.981622e-01 | 0.001 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 9.982554e-01 | 0.001 | 0 | 0 |
| rRNA processing in the mitochondrion | R-HSA-8868766 | 9.983503e-01 | 0.001 | 0 | 0 |
| Tryptophan catabolism | R-HSA-71240 | 9.983503e-01 | 0.001 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 9.984310e-01 | 0.001 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 9.984508e-01 | 0.001 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.985399e-01 | 0.001 | 0 | 0 |
| Retinoid metabolism and transport | R-HSA-975634 | 9.985399e-01 | 0.001 | 0 | 0 |
| Purine ribonucleoside monophosphate biosynthesis | R-HSA-73817 | 9.985608e-01 | 0.001 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.986052e-01 | 0.001 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.987140e-01 | 0.001 | 0 | 0 |
| SLC-mediated transport of neurotransmitters | R-HSA-442660 | 9.987445e-01 | 0.001 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.988682e-01 | 0.000 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.988742e-01 | 0.000 | 0 | 0 |
| Triglyceride metabolism | R-HSA-8979227 | 9.989094e-01 | 0.000 | 0 | 0 |
| ROS and RNS production in phagocytes | R-HSA-1222556 | 9.989631e-01 | 0.000 | 0 | 0 |
| Nucleotide salvage | R-HSA-8956321 | 9.991478e-01 | 0.000 | 0 | 0 |
| Endogenous sterols | R-HSA-211976 | 9.991478e-01 | 0.000 | 0 | 0 |
| Collagen degradation | R-HSA-1442490 | 9.991478e-01 | 0.000 | 0 | 0 |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | R-HSA-196741 | 9.991665e-01 | 0.000 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 9.991947e-01 | 0.000 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 9.992729e-01 | 0.000 | 0 | 0 |
| CD22 mediated BCR regulation | R-HSA-5690714 | 9.994122e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.994381e-01 | 0.000 | 0 | 0 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | R-HSA-2046104 | 9.994467e-01 | 0.000 | 0 | 0 |
| Metabolism of fat-soluble vitamins | R-HSA-6806667 | 9.995374e-01 | 0.000 | 0 | 0 |
| FCGR activation | R-HSA-2029481 | 9.995466e-01 | 0.000 | 0 | 0 |
| Nicotinate metabolism | R-HSA-196807 | 9.995952e-01 | 0.000 | 0 | 0 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | R-HSA-2162123 | 9.996327e-01 | 0.000 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.996426e-01 | 0.000 | 0 | 0 |
| Branched-chain amino acid catabolism | R-HSA-70895 | 9.996796e-01 | 0.000 | 0 | 0 |
| Complex IV assembly | R-HSA-9864848 | 9.996796e-01 | 0.000 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 9.997216e-01 | 0.000 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.997305e-01 | 0.000 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.997305e-01 | 0.000 | 0 | 0 |
| Aspirin ADME | R-HSA-9749641 | 9.998088e-01 | 0.000 | 0 | 0 |
| Chondroitin sulfate/dermatan sulfate metabolism | R-HSA-1793185 | 9.998145e-01 | 0.000 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 9.998506e-01 | 0.000 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.998589e-01 | 0.000 | 0 | 0 |
| Heparan sulfate/heparin (HS-GAG) metabolism | R-HSA-1638091 | 9.998926e-01 | 0.000 | 0 | 0 |
| Sialic acid metabolism | R-HSA-4085001 | 9.998926e-01 | 0.000 | 0 | 0 |
| SLC-mediated transport of organic anions | R-HSA-9955298 | 9.998980e-01 | 0.000 | 0 | 0 |
| Cholesterol biosynthesis | R-HSA-191273 | 9.998980e-01 | 0.000 | 0 | 0 |
| Interleukin-10 signaling | R-HSA-6783783 | 9.998980e-01 | 0.000 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.999081e-01 | 0.000 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 9.999183e-01 | 0.000 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 9.999255e-01 | 0.000 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 9.999320e-01 | 0.000 | 0 | 0 |
| Complex I biogenesis | R-HSA-6799198 | 9.999379e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation elongation | R-HSA-5389840 | 9.999446e-01 | 0.000 | 0 | 0 |
| Xenobiotics | R-HSA-211981 | 9.999458e-01 | 0.000 | 0 | 0 |
| Antimicrobial peptides | R-HSA-6803157 | 9.999518e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation initiation | R-HSA-5368286 | 9.999564e-01 | 0.000 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.999613e-01 | 0.000 | 0 | 0 |
| Metabolism of steroid hormones | R-HSA-196071 | 9.999640e-01 | 0.000 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 9.999640e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation | R-HSA-5368287 | 9.999710e-01 | 0.000 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.999758e-01 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 9.999789e-01 | 0.000 | 0 | 0 |
| Metal ion assimilation from the host | R-HSA-9638482 | 9.999792e-01 | 0.000 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 9.999792e-01 | 0.000 | 0 | 0 |
| Metabolism of porphyrins | R-HSA-189445 | 9.999792e-01 | 0.000 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 9.999804e-01 | 0.000 | 0 | 0 |
| Post-translational modification: synthesis of GPI-anchored proteins | R-HSA-163125 | 9.999812e-01 | 0.000 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.999825e-01 | 0.000 | 0 | 0 |
| Transport of vitamins, nucleosides, and related molecules | R-HSA-425397 | 9.999862e-01 | 0.000 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 9.999897e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation termination | R-HSA-5419276 | 9.999897e-01 | 0.000 | 0 | 0 |
| Mitochondrial Fatty Acid Beta-Oxidation | R-HSA-77289 | 9.999909e-01 | 0.000 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.999909e-01 | 0.000 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 9.999930e-01 | 0.000 | 0 | 0 |
| Metabolic disorders of biological oxidation enzymes | R-HSA-5579029 | 9.999930e-01 | 0.000 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 9.999933e-01 | 0.000 | 0 | 0 |
| Biosynthesis of DHA-derived SPMs | R-HSA-9018677 | 9.999947e-01 | 0.000 | 0 | 0 |
| Disease | R-HSA-1643685 | 9.999963e-01 | 0.000 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.999970e-01 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 9.999989e-01 | 0.000 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 9.999990e-01 | 0.000 | 0 | 0 |
| Scavenging of heme from plasma | R-HSA-2168880 | 9.999995e-01 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 9.999996e-01 | 0.000 | 0 | 0 |
| Regulation of Complement cascade | R-HSA-977606 | 9.999999e-01 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 9.999999e-01 | 0.000 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase II - Conjugation of compounds | R-HSA-156580 | 1.000000e+00 | 0.000 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 1.000000e+00 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 1.000000e+00 | 0.000 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 1.000000e+00 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 1.000000e+00 | 0.000 | 0 | 0 |
| Complement cascade | R-HSA-166658 | 1.000000e+00 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 1.000000e+00 | 0.000 | 0 | 0 |
| Synthesis of substrates in N-glycan biosythesis | R-HSA-446219 | 1.000000e+00 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 1.000000e+00 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 1.000000e+00 | 0.000 | 0 | 0 |
| O-linked glycosylation | R-HSA-5173105 | 1.000000e+00 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 1.000000e+00 | 0.000 | 0 | 0 |
| Biosynthesis of specialized proresolving mediators (SPMs) | R-HSA-9018678 | 1.000000e+00 | 0.000 | 0 | 0 |
| Cytochrome P450 - arranged by substrate type | R-HSA-211897 | 1.000000e+00 | 0.000 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 1.000000e+00 | 0.000 | 0 | 0 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | R-HSA-446193 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 1.000000e+00 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 1.000000e+00 | 0.000 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase I - Functionalization of compounds | R-HSA-211945 | 1.000000e+00 | 0.000 | 0 | 0 |
| Infection with Enterobacteria | R-HSA-9640148 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | 0.000 | 0 | 0 |
| Expression and translocation of olfactory receptors | R-HSA-9752946 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 0 | 0 |
| Olfactory Signaling Pathway | R-HSA-381753 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 1.000000e+00 | -0.000 | 0 | 0 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
| name | reactome_id | p | -log10p | ref_path | ref_path_lowest |
|---|---|---|---|---|---|
| M Phase | R-HSA-68886 | 1.110223e-16 | 15.955 | 0 | 0 |
| Cell Cycle | R-HSA-1640170 | 1.110223e-16 | 15.955 | 0 | 0 |
| Cell Cycle, Mitotic | R-HSA-69278 | 1.110223e-16 | 15.955 | 0 | 0 |
| Metabolism of RNA | R-HSA-8953854 | 1.110223e-16 | 15.955 | 0 | 0 |
| Cell Cycle Checkpoints | R-HSA-69620 | 3.663736e-15 | 14.436 | 0 | 0 |
| G2/M Checkpoints | R-HSA-69481 | 7.771561e-14 | 13.109 | 0 | 0 |
| Separation of Sister Chromatids | R-HSA-2467813 | 1.161848e-12 | 11.935 | 0 | 0 |
| Mitotic Anaphase | R-HSA-68882 | 1.102118e-12 | 11.958 | 0 | 0 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 1.311729e-12 | 11.882 | 0 | 0 |
| G2/M DNA damage checkpoint | R-HSA-69473 | 1.565414e-12 | 11.805 | 0 | 0 |
| Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 2.605138e-12 | 11.584 | 0 | 0 |
| mRNA Splicing - Major Pathway | R-HSA-72163 | 1.325673e-11 | 10.878 | 0 | 0 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | R-HSA-5693565 | 2.467049e-11 | 10.608 | 0 | 0 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | R-HSA-1445148 | 2.352585e-11 | 10.628 | 0 | 0 |
| Cell-Cell communication | R-HSA-1500931 | 2.753064e-11 | 10.560 | 0 | 0 |
| mRNA Splicing | R-HSA-72172 | 2.973255e-11 | 10.527 | 0 | 0 |
| Apoptotic execution phase | R-HSA-75153 | 1.463211e-10 | 9.835 | 0 | 0 |
| Cellular responses to stress | R-HSA-2262752 | 1.460498e-10 | 9.835 | 0 | 0 |
| Mitotic Prometaphase | R-HSA-68877 | 2.685443e-10 | 9.571 | 0 | 0 |
| Nonhomologous End-Joining (NHEJ) | R-HSA-5693571 | 3.050561e-10 | 9.516 | 0 | 0 |
| DNA Double Strand Break Response | R-HSA-5693606 | 3.225277e-10 | 9.491 | 0 | 0 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 5.158147e-10 | 9.288 | 0 | 0 |
| Regulation of Expression and Function of Type I Classical Cadherins | R-HSA-9764274 | 6.503881e-10 | 9.187 | 0 | 0 |
| Regulation of CDH1 Expression and Function | R-HSA-9764265 | 6.503881e-10 | 9.187 | 0 | 0 |
| G2/M Transition | R-HSA-69275 | 6.825263e-10 | 9.166 | 0 | 0 |
| Adherens junctions interactions | R-HSA-418990 | 7.322162e-10 | 9.135 | 0 | 0 |
| Cellular responses to stimuli | R-HSA-8953897 | 7.395635e-10 | 9.131 | 0 | 0 |
| Mitotic G2-G2/M phases | R-HSA-453274 | 9.389436e-10 | 9.027 | 0 | 0 |
| Aggrephagy | R-HSA-9646399 | 1.486706e-09 | 8.828 | 0 | 0 |
| Processing of DNA double-strand break ends | R-HSA-5693607 | 3.637541e-09 | 8.439 | 0 | 0 |
| DNA Double-Strand Break Repair | R-HSA-5693532 | 3.766036e-09 | 8.424 | 0 | 0 |
| Cell junction organization | R-HSA-446728 | 3.776748e-09 | 8.423 | 0 | 0 |
| Positive epigenetic regulation of rRNA expression | R-HSA-5250913 | 4.159663e-09 | 8.381 | 0 | 0 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 4.264588e-09 | 8.370 | 0 | 0 |
| Apoptosis | R-HSA-109581 | 5.865312e-09 | 8.232 | 0 | 0 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | R-HSA-8852276 | 5.810722e-09 | 8.236 | 0 | 0 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 6.779939e-09 | 8.169 | 0 | 0 |
| Regulation of Homotypic Cell-Cell Adhesion | R-HSA-9759476 | 8.475869e-09 | 8.072 | 0 | 0 |
| Negative Regulation of CDH1 Gene Transcription | R-HSA-9764725 | 1.374447e-08 | 7.862 | 0 | 0 |
| Kinesins | R-HSA-983189 | 1.374447e-08 | 7.862 | 0 | 0 |
| Assembly and cell surface presentation of NMDA receptors | R-HSA-9609736 | 1.546244e-08 | 7.811 | 0 | 0 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | R-HSA-450531 | 2.097072e-08 | 7.678 | 0 | 0 |
| Homology Directed Repair | R-HSA-5693538 | 2.345178e-08 | 7.630 | 0 | 0 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 2.383523e-08 | 7.623 | 0 | 0 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | R-HSA-5693567 | 2.356379e-08 | 7.628 | 0 | 0 |
| Cell-cell junction organization | R-HSA-421270 | 2.451997e-08 | 7.610 | 0 | 0 |
| Cellular Senescence | R-HSA-2559583 | 3.920468e-08 | 7.407 | 0 | 0 |
| Formation of tubulin folding intermediates by CCT/TriC | R-HSA-389960 | 4.329951e-08 | 7.364 | 0 | 0 |
| Regulation of CDH1 Gene Transcription | R-HSA-9764560 | 4.822587e-08 | 7.317 | 0 | 0 |
| Programmed Cell Death | R-HSA-5357801 | 8.441867e-08 | 7.074 | 0 | 0 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 8.560664e-08 | 7.067 | 0 | 0 |
| Mitotic Prophase | R-HSA-68875 | 1.007778e-07 | 6.997 | 0 | 0 |
| Recycling pathway of L1 | R-HSA-437239 | 1.040328e-07 | 6.983 | 0 | 0 |
| rRNA processing in the nucleus and cytosol | R-HSA-8868773 | 1.188783e-07 | 6.925 | 0 | 0 |
| Cellular response to heat stress | R-HSA-3371556 | 1.197623e-07 | 6.922 | 0 | 0 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | R-HSA-389958 | 1.347189e-07 | 6.871 | 0 | 0 |
| Meiotic synapsis | R-HSA-1221632 | 1.367185e-07 | 6.864 | 0 | 0 |
| B-WICH complex positively regulates rRNA expression | R-HSA-5250924 | 1.367185e-07 | 6.864 | 0 | 0 |
| PKR-mediated signaling | R-HSA-9833482 | 1.368557e-07 | 6.864 | 0 | 0 |
| Prefoldin mediated transfer of substrate to CCT/TriC | R-HSA-389957 | 1.663226e-07 | 6.779 | 0 | 0 |
| Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | R-HSA-9845323 | 2.176355e-07 | 6.662 | 0 | 0 |
| Activation of AMPK downstream of NMDARs | R-HSA-9619483 | 2.277875e-07 | 6.642 | 0 | 0 |
| Mitotic Telophase/Cytokinesis | R-HSA-68884 | 2.594775e-07 | 6.586 | 0 | 0 |
| Regulation of PD-L1(CD274) transcription | R-HSA-9909649 | 2.521444e-07 | 6.598 | 0 | 0 |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | R-HSA-190840 | 2.506161e-07 | 6.601 | 0 | 0 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 2.674741e-07 | 6.573 | 0 | 0 |
| Recruitment of NuMA to mitotic centrosomes | R-HSA-380320 | 2.708626e-07 | 6.567 | 0 | 0 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | R-HSA-3371497 | 4.019808e-07 | 6.396 | 0 | 0 |
| E3 ubiquitin ligases ubiquitinate target proteins | R-HSA-8866654 | 4.197112e-07 | 6.377 | 0 | 0 |
| Major pathway of rRNA processing in the nucleolus and cytosol | R-HSA-6791226 | 4.140607e-07 | 6.383 | 0 | 0 |
| Transport of connexons to the plasma membrane | R-HSA-190872 | 4.104402e-07 | 6.387 | 0 | 0 |
| L1CAM interactions | R-HSA-373760 | 4.293517e-07 | 6.367 | 0 | 0 |
| Cohesin Loading onto Chromatin | R-HSA-2470946 | 5.994738e-07 | 6.222 | 0 | 0 |
| NoRC negatively regulates rRNA expression | R-HSA-427413 | 7.846353e-07 | 6.105 | 0 | 0 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | R-HSA-427389 | 7.894602e-07 | 6.103 | 0 | 0 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 8.697621e-07 | 6.061 | 0 | 0 |
| RNA Polymerase I Transcription | R-HSA-73864 | 1.018593e-06 | 5.992 | 0 | 0 |
| Meiosis | R-HSA-1500620 | 1.266131e-06 | 5.898 | 0 | 0 |
| Nervous system development | R-HSA-9675108 | 1.294222e-06 | 5.888 | 0 | 0 |
| Regulation of CDH1 Function | R-HSA-9764561 | 1.463499e-06 | 5.835 | 0 | 0 |
| Protein ubiquitination | R-HSA-8852135 | 1.814861e-06 | 5.741 | 0 | 0 |
| DNA Repair | R-HSA-73894 | 1.759723e-06 | 5.755 | 0 | 0 |
| S Phase | R-HSA-69242 | 1.842575e-06 | 5.735 | 0 | 0 |
| RNA Polymerase I Promoter Clearance | R-HSA-73854 | 2.218342e-06 | 5.654 | 0 | 0 |
| Post NMDA receptor activation events | R-HSA-438064 | 2.227202e-06 | 5.652 | 0 | 0 |
| EML4 and NUDC in mitotic spindle formation | R-HSA-9648025 | 2.231298e-06 | 5.651 | 0 | 0 |
| Axon guidance | R-HSA-422475 | 3.121249e-06 | 5.506 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | R-HSA-8939236 | 3.266474e-06 | 5.486 | 0 | 0 |
| Regulation of PLK1 Activity at G2/M Transition | R-HSA-2565942 | 3.266474e-06 | 5.486 | 0 | 0 |
| HDACs deacetylate histones | R-HSA-3214815 | 3.327305e-06 | 5.478 | 0 | 0 |
| Nucleosome assembly | R-HSA-774815 | 4.101980e-06 | 5.387 | 0 | 0 |
| Deposition of new CENPA-containing nucleosomes at the centromere | R-HSA-606279 | 4.101980e-06 | 5.387 | 0 | 0 |
| Epigenetic regulation of gene expression | R-HSA-212165 | 4.148351e-06 | 5.382 | 0 | 0 |
| Negative epigenetic regulation of rRNA expression | R-HSA-5250941 | 4.790829e-06 | 5.320 | 0 | 0 |
| Signaling by ALK fusions and activated point mutants | R-HSA-9725370 | 4.509733e-06 | 5.346 | 0 | 0 |
| Signaling by ALK in cancer | R-HSA-9700206 | 4.509733e-06 | 5.346 | 0 | 0 |
| Nuclear Envelope (NE) Reassembly | R-HSA-2995410 | 4.790829e-06 | 5.320 | 0 | 0 |
| Regulation of endogenous retroelements | R-HSA-9842860 | 4.832681e-06 | 5.316 | 0 | 0 |
| Post-chaperonin tubulin folding pathway | R-HSA-389977 | 5.866756e-06 | 5.232 | 0 | 0 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | R-HSA-75035 | 6.182300e-06 | 5.209 | 0 | 0 |
| Regulation of PD-L1(CD274) expression | R-HSA-9909648 | 7.365252e-06 | 5.133 | 0 | 0 |
| DNA Replication | R-HSA-69306 | 8.585524e-06 | 5.066 | 0 | 0 |
| Deubiquitination | R-HSA-5688426 | 9.555008e-06 | 5.020 | 0 | 0 |
| Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | R-HSA-9843970 | 1.079905e-05 | 4.967 | 0 | 0 |
| Chromatin organization | R-HSA-4839726 | 1.114151e-05 | 4.953 | 0 | 0 |
| Interferon Signaling | R-HSA-913531 | 1.209304e-05 | 4.917 | 0 | 0 |
| Diseases of signal transduction by growth factor receptors and second messengers | R-HSA-5663202 | 1.189529e-05 | 4.925 | 0 | 0 |
| Gap junction trafficking | R-HSA-190828 | 1.214850e-05 | 4.915 | 0 | 0 |
| Chaperone Mediated Autophagy | R-HSA-9613829 | 1.466084e-05 | 4.834 | 0 | 0 |
| HSF1-dependent transactivation | R-HSA-3371571 | 1.691461e-05 | 4.772 | 0 | 0 |
| PRC2 methylates histones and DNA | R-HSA-212300 | 1.862029e-05 | 4.730 | 0 | 0 |
| Ub-specific processing proteases | R-HSA-5689880 | 1.871752e-05 | 4.728 | 0 | 0 |
| RNA Polymerase I Promoter Opening | R-HSA-73728 | 1.928703e-05 | 4.715 | 0 | 0 |
| rRNA processing | R-HSA-72312 | 1.940332e-05 | 4.712 | 0 | 0 |
| Selective autophagy | R-HSA-9663891 | 2.276099e-05 | 4.643 | 0 | 0 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | R-HSA-9668328 | 2.570448e-05 | 4.590 | 0 | 0 |
| Smooth Muscle Contraction | R-HSA-445355 | 2.597754e-05 | 4.585 | 0 | 0 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | R-HSA-8950505 | 2.681524e-05 | 4.572 | 0 | 0 |
| Estrogen-dependent gene expression | R-HSA-9018519 | 2.987200e-05 | 4.525 | 0 | 0 |
| Replacement of protamines by nucleosomes in the male pronucleus | R-HSA-9821993 | 3.441926e-05 | 4.463 | 0 | 0 |
| Establishment of Sister Chromatid Cohesion | R-HSA-2468052 | 3.779342e-05 | 4.423 | 0 | 0 |
| Developmental Lineage of Mammary Gland Myoepithelial Cells | R-HSA-9927432 | 3.503248e-05 | 4.456 | 0 | 0 |
| Regulation of HSF1-mediated heat shock response | R-HSA-3371453 | 3.534840e-05 | 4.452 | 0 | 0 |
| Activation of NMDA receptors and postsynaptic events | R-HSA-442755 | 3.534840e-05 | 4.452 | 0 | 0 |
| Gap junction trafficking and regulation | R-HSA-157858 | 3.777163e-05 | 4.423 | 0 | 0 |
| COPI-dependent Golgi-to-ER retrograde traffic | R-HSA-6811434 | 3.888239e-05 | 4.410 | 0 | 0 |
| COPI-independent Golgi-to-ER retrograde traffic | R-HSA-6811436 | 3.913626e-05 | 4.407 | 0 | 0 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 4.401020e-05 | 4.356 | 0 | 0 |
| Chromatin modifying enzymes | R-HSA-3247509 | 4.733991e-05 | 4.325 | 0 | 0 |
| Ribosomal scanning and start codon recognition | R-HSA-72702 | 4.770934e-05 | 4.321 | 0 | 0 |
| Attenuation phase | R-HSA-3371568 | 5.038454e-05 | 4.298 | 0 | 0 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 5.087960e-05 | 4.293 | 0 | 0 |
| Cilium Assembly | R-HSA-5617833 | 5.111785e-05 | 4.291 | 0 | 0 |
| Loss of proteins required for interphase microtubule organization from the centrosome | R-HSA-380284 | 5.714280e-05 | 4.243 | 0 | 0 |
| Loss of Nlp from mitotic centrosomes | R-HSA-380259 | 5.714280e-05 | 4.243 | 0 | 0 |
| rRNA modification in the nucleus and cytosol | R-HSA-6790901 | 5.714280e-05 | 4.243 | 0 | 0 |
| MHC class II antigen presentation | R-HSA-2132295 | 5.604524e-05 | 4.251 | 0 | 0 |
| Interleukin-12 family signaling | R-HSA-447115 | 5.379230e-05 | 4.269 | 0 | 0 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 5.811583e-05 | 4.236 | 0 | 0 |
| Formation of the polybromo-BAF (pBAF) complex | R-HSA-9933939 | 6.170894e-05 | 4.210 | 0 | 0 |
| Interleukin-12 signaling | R-HSA-9020591 | 6.216342e-05 | 4.206 | 0 | 0 |
| Co-inhibition by PD-1 | R-HSA-389948 | 6.474989e-05 | 4.189 | 0 | 0 |
| Autodegradation of Cdh1 by Cdh1:APC/C | R-HSA-174084 | 6.794518e-05 | 4.168 | 0 | 0 |
| Formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 6.998826e-05 | 4.155 | 0 | 0 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 6.998826e-05 | 4.155 | 0 | 0 |
| HSF1 activation | R-HSA-3371511 | 7.197556e-05 | 4.143 | 0 | 0 |
| Anchoring of the basal body to the plasma membrane | R-HSA-5620912 | 8.430244e-05 | 4.074 | 0 | 0 |
| Deactivation of the beta-catenin transactivating complex | R-HSA-3769402 | 9.128386e-05 | 4.040 | 0 | 0 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 9.056079e-05 | 4.043 | 0 | 0 |
| Golgi-to-ER retrograde transport | R-HSA-8856688 | 8.963304e-05 | 4.048 | 0 | 0 |
| Transcriptional regulation by RUNX1 | R-HSA-8878171 | 9.220055e-05 | 4.035 | 0 | 0 |
| Activation of BAD and translocation to mitochondria | R-HSA-111447 | 9.251787e-05 | 4.034 | 0 | 0 |
| AURKA Activation by TPX2 | R-HSA-8854518 | 9.706333e-05 | 4.013 | 0 | 0 |
| Translation initiation complex formation | R-HSA-72649 | 1.030736e-04 | 3.987 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Cyclin B | R-HSA-174048 | 1.091253e-04 | 3.962 | 0 | 0 |
| MITF-M-regulated melanocyte development | R-HSA-9730414 | 1.155564e-04 | 3.937 | 0 | 0 |
| Defective pyroptosis | R-HSA-9710421 | 1.223312e-04 | 3.912 | 0 | 0 |
| Striated Muscle Contraction | R-HSA-390522 | 1.306924e-04 | 3.884 | 0 | 0 |
| Cap-dependent Translation Initiation | R-HSA-72737 | 1.341267e-04 | 3.872 | 0 | 0 |
| Eukaryotic Translation Initiation | R-HSA-72613 | 1.341267e-04 | 3.872 | 0 | 0 |
| Recognition of DNA damage by PCNA-containing replication complex | R-HSA-110314 | 1.524593e-04 | 3.817 | 0 | 0 |
| DNA methylation | R-HSA-5334118 | 1.442079e-04 | 3.841 | 0 | 0 |
| Chaperonin-mediated protein folding | R-HSA-390466 | 1.435206e-04 | 3.843 | 0 | 0 |
| Nephrin family interactions | R-HSA-373753 | 1.511827e-04 | 3.820 | 0 | 0 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 1.483446e-04 | 3.829 | 0 | 0 |
| Diseases of programmed cell death | R-HSA-9645723 | 1.654353e-04 | 3.781 | 0 | 0 |
| Gap junction assembly | R-HSA-190861 | 1.656931e-04 | 3.781 | 0 | 0 |
| Meiotic recombination | R-HSA-912446 | 1.834288e-04 | 3.737 | 0 | 0 |
| HCMV Early Events | R-HSA-9609690 | 1.848848e-04 | 3.733 | 0 | 0 |
| SWI/SNF chromatin remodelers | R-HSA-9932451 | 2.013088e-04 | 3.696 | 0 | 0 |
| ATP-dependent chromatin remodelers | R-HSA-9932444 | 2.013088e-04 | 3.696 | 0 | 0 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 2.205477e-04 | 3.656 | 0 | 0 |
| RNA Polymerase I Promoter Escape | R-HSA-73772 | 2.205477e-04 | 3.656 | 0 | 0 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 2.224366e-04 | 3.653 | 0 | 0 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 2.238477e-04 | 3.650 | 0 | 0 |
| Transcriptional regulation by small RNAs | R-HSA-5578749 | 2.558138e-04 | 3.592 | 0 | 0 |
| Apoptosis induced DNA fragmentation | R-HSA-140342 | 2.563695e-04 | 3.591 | 0 | 0 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 2.640127e-04 | 3.578 | 0 | 0 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | R-HSA-174178 | 2.640127e-04 | 3.578 | 0 | 0 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | R-HSA-9617324 | 2.769591e-04 | 3.558 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of Securin | R-HSA-174154 | 2.709436e-04 | 3.567 | 0 | 0 |
| Recruitment of mitotic centrosome proteins and complexes | R-HSA-380270 | 2.974440e-04 | 3.527 | 0 | 0 |
| Signaling by RAF1 mutants | R-HSA-9656223 | 2.705571e-04 | 3.568 | 0 | 0 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 2.974440e-04 | 3.527 | 0 | 0 |
| Autophagy | R-HSA-9612973 | 2.948768e-04 | 3.530 | 0 | 0 |
| Macroautophagy | R-HSA-1632852 | 2.676614e-04 | 3.572 | 0 | 0 |
| CDK-mediated phosphorylation and removal of Cdc6 | R-HSA-69017 | 3.147004e-04 | 3.502 | 0 | 0 |
| Protein folding | R-HSA-391251 | 3.254900e-04 | 3.487 | 0 | 0 |
| EPH-Ephrin signaling | R-HSA-2682334 | 3.254900e-04 | 3.487 | 0 | 0 |
| Intraflagellar transport | R-HSA-5620924 | 3.263404e-04 | 3.486 | 0 | 0 |
| Packaging Of Telomere Ends | R-HSA-171306 | 3.394319e-04 | 3.469 | 0 | 0 |
| Viral Infection Pathways | R-HSA-9824446 | 3.689410e-04 | 3.433 | 0 | 0 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 3.735768e-04 | 3.428 | 0 | 0 |
| Centrosome maturation | R-HSA-380287 | 3.987201e-04 | 3.399 | 0 | 0 |
| Regulation of PTEN localization | R-HSA-8948747 | 3.998301e-04 | 3.398 | 0 | 0 |
| SARS-CoV-1-host interactions | R-HSA-9692914 | 4.107966e-04 | 3.386 | 0 | 0 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 4.114223e-04 | 3.386 | 0 | 0 |
| Transport of Mature Transcript to Cytoplasm | R-HSA-72202 | 4.118683e-04 | 3.385 | 0 | 0 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 4.174292e-04 | 3.379 | 0 | 0 |
| Hedgehog 'off' state | R-HSA-5610787 | 4.174292e-04 | 3.379 | 0 | 0 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 4.417026e-04 | 3.355 | 0 | 0 |
| Synthesis of DNA | R-HSA-69239 | 4.615903e-04 | 3.336 | 0 | 0 |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | R-HSA-9755779 | 4.851548e-04 | 3.314 | 0 | 0 |
| Regulation of endogenous retroelements by KRAB-ZFP proteins | R-HSA-9843940 | 5.097825e-04 | 3.293 | 0 | 0 |
| Regulation of T cell activation by CD28 family | R-HSA-388841 | 5.286916e-04 | 3.277 | 0 | 0 |
| Membrane Trafficking | R-HSA-199991 | 5.836880e-04 | 3.234 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | R-HSA-110328 | 5.848069e-04 | 3.233 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperone genes | R-HSA-381183 | 5.957438e-04 | 3.225 | 0 | 0 |
| Signaling by BRAF and RAF1 fusions | R-HSA-6802952 | 6.513438e-04 | 3.186 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence | R-HSA-9825895 | 6.553286e-04 | 3.184 | 0 | 0 |
| HIV Life Cycle | R-HSA-162587 | 6.644664e-04 | 3.178 | 0 | 0 |
| Downregulation of ERBB2 signaling | R-HSA-8863795 | 6.901978e-04 | 3.161 | 0 | 0 |
| Signaling downstream of RAS mutants | R-HSA-9649948 | 6.934574e-04 | 3.159 | 0 | 0 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | R-HSA-6802955 | 6.934574e-04 | 3.159 | 0 | 0 |
| Signaling by moderate kinase activity BRAF mutants | R-HSA-6802946 | 6.934574e-04 | 3.159 | 0 | 0 |
| Signaling by RAS mutants | R-HSA-6802949 | 6.934574e-04 | 3.159 | 0 | 0 |
| MITF-M-dependent gene expression | R-HSA-9856651 | 7.098203e-04 | 3.149 | 0 | 0 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | R-HSA-5625886 | 7.168337e-04 | 3.145 | 0 | 0 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 7.270158e-04 | 3.138 | 1 | 0 |
| Regulation of TP53 Activity through Phosphorylation | R-HSA-6804756 | 7.928948e-04 | 3.101 | 1 | 1 |
| Regulation of TP53 Activity | R-HSA-5633007 | 8.680404e-04 | 3.061 | 1 | 0 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | R-HSA-450408 | 8.775149e-04 | 3.057 | 0 | 0 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 8.931713e-04 | 3.049 | 0 | 0 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | R-HSA-6811442 | 9.653393e-04 | 3.015 | 0 | 0 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | R-HSA-8936459 | 1.002333e-03 | 2.999 | 0 | 0 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 1.022076e-03 | 2.991 | 0 | 0 |
| HuR (ELAVL1) binds and stabilizes mRNA | R-HSA-450520 | 1.022076e-03 | 2.991 | 0 | 0 |
| Recognition and association of DNA glycosylase with site containing an affected purine | R-HSA-110330 | 1.061167e-03 | 2.974 | 0 | 0 |
| Unblocking of NMDA receptors, glutamate binding and activation | R-HSA-438066 | 1.141447e-03 | 2.943 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | R-HSA-5696397 | 1.141447e-03 | 2.943 | 0 | 0 |
| Ras activation upon Ca2+ influx through NMDA receptor | R-HSA-442982 | 1.141447e-03 | 2.943 | 0 | 0 |
| Degradation of CDH1 | R-HSA-9766229 | 1.150329e-03 | 2.939 | 0 | 0 |
| L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 1.159645e-03 | 2.936 | 0 | 0 |
| Chromosome Maintenance | R-HSA-73886 | 1.162939e-03 | 2.934 | 0 | 0 |
| ATF6 (ATF6-alpha) activates chaperones | R-HSA-381033 | 1.221620e-03 | 2.913 | 0 | 0 |
| HIV Infection | R-HSA-162906 | 1.255073e-03 | 2.901 | 0 | 0 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 1.357068e-03 | 2.867 | 0 | 0 |
| Nuclear Envelope Breakdown | R-HSA-2980766 | 1.432771e-03 | 2.844 | 0 | 0 |
| Semaphorin interactions | R-HSA-373755 | 1.288695e-03 | 2.890 | 0 | 0 |
| TP53 Regulates Transcription of DNA Repair Genes | R-HSA-6796648 | 1.500438e-03 | 2.824 | 0 | 0 |
| Assembly of the ORC complex at the origin of replication | R-HSA-68616 | 1.300713e-03 | 2.886 | 0 | 0 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 1.502673e-03 | 2.823 | 0 | 0 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 1.502673e-03 | 2.823 | 0 | 0 |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA | R-HSA-428359 | 1.529024e-03 | 2.816 | 0 | 0 |
| Transport of Mature mRNA Derived from an Intronless Transcript | R-HSA-159231 | 1.538080e-03 | 2.813 | 0 | 0 |
| Stabilization of p53 | R-HSA-69541 | 1.538080e-03 | 2.813 | 0 | 0 |
| Reproduction | R-HSA-1474165 | 1.604174e-03 | 2.795 | 0 | 0 |
| TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | R-HSA-8869496 | 1.691265e-03 | 2.772 | 0 | 0 |
| Signaling by Hedgehog | R-HSA-5358351 | 1.792854e-03 | 2.746 | 0 | 0 |
| Gene expression (Transcription) | R-HSA-74160 | 1.828219e-03 | 2.738 | 1 | 0 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | R-HSA-159234 | 1.833163e-03 | 2.737 | 0 | 0 |
| Inhibition of DNA recombination at telomere | R-HSA-9670095 | 1.833163e-03 | 2.737 | 0 | 0 |
| Dual Incision in GG-NER | R-HSA-5696400 | 1.913387e-03 | 2.718 | 0 | 0 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | R-HSA-159236 | 1.941892e-03 | 2.712 | 0 | 0 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 1.957136e-03 | 2.708 | 0 | 0 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 2.064998e-03 | 2.685 | 0 | 0 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 2.104104e-03 | 2.677 | 0 | 0 |
| Translesion Synthesis by POLH | R-HSA-110320 | 2.107485e-03 | 2.676 | 0 | 0 |
| Organelle biogenesis and maintenance | R-HSA-1852241 | 2.136987e-03 | 2.670 | 0 | 0 |
| Amyloid fiber formation | R-HSA-977225 | 2.158423e-03 | 2.666 | 0 | 0 |
| Chromatin modifications during the maternal to zygotic transition (MZT) | R-HSA-9821002 | 2.173166e-03 | 2.663 | 0 | 0 |
| Signaling by ERBB2 | R-HSA-1227986 | 2.193000e-03 | 2.659 | 0 | 0 |
| InlA-mediated entry of Listeria monocytogenes into host cells | R-HSA-8876493 | 2.207740e-03 | 2.656 | 0 | 0 |
| Regulation of localization of FOXO transcription factors | R-HSA-9614399 | 2.207740e-03 | 2.656 | 0 | 0 |
| HDR through Homologous Recombination (HRR) | R-HSA-5685942 | 2.213170e-03 | 2.655 | 0 | 0 |
| SARS-CoV-1 targets host intracellular signalling and regulatory pathways | R-HSA-9735871 | 2.273332e-03 | 2.643 | 0 | 0 |
| Carboxyterminal post-translational modifications of tubulin | R-HSA-8955332 | 2.351766e-03 | 2.629 | 0 | 0 |
| SARS-CoV-2-host interactions | R-HSA-9705683 | 2.377698e-03 | 2.624 | 0 | 0 |
| ESR-mediated signaling | R-HSA-8939211 | 2.473992e-03 | 2.607 | 0 | 0 |
| Muscle contraction | R-HSA-397014 | 2.491155e-03 | 2.604 | 0 | 0 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | R-HSA-9687136 | 3.009399e-03 | 2.522 | 0 | 0 |
| Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | R-HSA-9934037 | 2.697628e-03 | 2.569 | 0 | 0 |
| Long-term potentiation | R-HSA-9620244 | 2.865939e-03 | 2.543 | 0 | 0 |
| Global Genome Nucleotide Excision Repair (GG-NER) | R-HSA-5696399 | 3.043202e-03 | 2.517 | 0 | 0 |
| DNA Damage Bypass | R-HSA-73893 | 3.170449e-03 | 2.499 | 0 | 0 |
| Sema4D induced cell migration and growth-cone collapse | R-HSA-416572 | 2.697628e-03 | 2.569 | 0 | 0 |
| COPI-mediated anterograde transport | R-HSA-6807878 | 3.086996e-03 | 2.510 | 0 | 0 |
| TCR signaling | R-HSA-202403 | 3.027588e-03 | 2.519 | 0 | 0 |
| RNA Polymerase I Transcription Initiation | R-HSA-73762 | 3.007953e-03 | 2.522 | 0 | 0 |
| Sema4D in semaphorin signaling | R-HSA-400685 | 2.865939e-03 | 2.543 | 0 | 0 |
| Transcriptional regulation of granulopoiesis | R-HSA-9616222 | 2.865991e-03 | 2.543 | 0 | 0 |
| Cleavage of the damaged pyrimidine | R-HSA-110329 | 3.007953e-03 | 2.522 | 0 | 0 |
| Depyrimidination | R-HSA-73928 | 3.007953e-03 | 2.522 | 0 | 0 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | R-HSA-6782210 | 3.249041e-03 | 2.488 | 0 | 0 |
| SIRT1 negatively regulates rRNA expression | R-HSA-427359 | 3.254411e-03 | 2.488 | 0 | 0 |
| Cleavage of the damaged purine | R-HSA-110331 | 3.254411e-03 | 2.488 | 0 | 0 |
| HCMV Infection | R-HSA-9609646 | 3.292005e-03 | 2.483 | 0 | 0 |
| TGF-beta receptor signaling activates SMADs | R-HSA-2173789 | 3.513462e-03 | 2.454 | 0 | 0 |
| Cargo trafficking to the periciliary membrane | R-HSA-5620920 | 3.634315e-03 | 2.440 | 0 | 0 |
| Signaling by VEGF | R-HSA-194138 | 3.775332e-03 | 2.423 | 0 | 0 |
| Depurination | R-HSA-73927 | 3.840042e-03 | 2.416 | 0 | 0 |
| Nucleotide Excision Repair | R-HSA-5696398 | 3.904983e-03 | 2.408 | 0 | 0 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 3.915118e-03 | 2.407 | 0 | 0 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 3.915118e-03 | 2.407 | 0 | 0 |
| Apoptotic cleavage of cell adhesion proteins | R-HSA-351906 | 3.968182e-03 | 2.401 | 0 | 0 |
| Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | R-HSA-9828211 | 3.968182e-03 | 2.401 | 0 | 0 |
| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | R-HSA-8849469 | 3.968182e-03 | 2.401 | 0 | 0 |
| Regulation of MECP2 expression and activity | R-HSA-9022692 | 4.115305e-03 | 2.386 | 0 | 0 |
| HATs acetylate histones | R-HSA-3214847 | 4.162477e-03 | 2.381 | 0 | 0 |
| Dual incision in TC-NER | R-HSA-6782135 | 4.233451e-03 | 2.373 | 0 | 0 |
| EPHA-mediated growth cone collapse | R-HSA-3928663 | 4.283589e-03 | 2.368 | 0 | 0 |
| NrCAM interactions | R-HSA-447038 | 4.422382e-03 | 2.354 | 0 | 0 |
| FLT3 signaling by CBL mutants | R-HSA-9706377 | 4.422382e-03 | 2.354 | 0 | 0 |
| ABC-family proteins mediated transport | R-HSA-382556 | 4.583571e-03 | 2.339 | 0 | 0 |
| Gene Silencing by RNA | R-HSA-211000 | 4.704598e-03 | 2.327 | 0 | 0 |
| Defective CFTR causes cystic fibrosis | R-HSA-5678895 | 4.729569e-03 | 2.325 | 0 | 0 |
| AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | R-HSA-9931269 | 4.819782e-03 | 2.317 | 0 | 0 |
| mRNA 3'-end processing | R-HSA-72187 | 4.819782e-03 | 2.317 | 0 | 0 |
| DNA Damage Recognition in GG-NER | R-HSA-5696394 | 4.888538e-03 | 2.311 | 0 | 0 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | R-HSA-176407 | 5.013801e-03 | 2.300 | 0 | 0 |
| Signaling by Hippo | R-HSA-2028269 | 5.013801e-03 | 2.300 | 0 | 0 |
| Signaling by NOTCH | R-HSA-157118 | 5.059870e-03 | 2.296 | 0 | 0 |
| Signaling by NOTCH4 | R-HSA-9013694 | 5.133423e-03 | 2.290 | 0 | 0 |
| Drug resistance in ERBB2 KD mutants | R-HSA-9665230 | 6.456246e-03 | 2.190 | 0 | 0 |
| Activation, myristolyation of BID and translocation to mitochondria | R-HSA-75108 | 6.456246e-03 | 2.190 | 0 | 0 |
| Drug-mediated inhibition of ERBB2 signaling | R-HSA-9652282 | 6.456246e-03 | 2.190 | 0 | 0 |
| Resistance of ERBB2 KD mutants to tesevatinib | R-HSA-9665245 | 6.456246e-03 | 2.190 | 0 | 0 |
| Resistance of ERBB2 KD mutants to osimertinib | R-HSA-9665247 | 6.456246e-03 | 2.190 | 0 | 0 |
| Resistance of ERBB2 KD mutants to sapitinib | R-HSA-9665244 | 6.456246e-03 | 2.190 | 0 | 0 |
| Resistance of ERBB2 KD mutants to AEE788 | R-HSA-9665250 | 6.456246e-03 | 2.190 | 0 | 0 |
| Resistance of ERBB2 KD mutants to neratinib | R-HSA-9665246 | 6.456246e-03 | 2.190 | 0 | 0 |
| Resistance of ERBB2 KD mutants to lapatinib | R-HSA-9665251 | 6.456246e-03 | 2.190 | 0 | 0 |
| Resistance of ERBB2 KD mutants to afatinib | R-HSA-9665249 | 6.456246e-03 | 2.190 | 0 | 0 |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | 6.456246e-03 | 2.190 | 0 | 0 |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | 6.456246e-03 | 2.190 | 0 | 0 |
| Formation of the non-canonical BAF (ncBAF) complex | R-HSA-9933947 | 5.617744e-03 | 2.250 | 0 | 0 |
| Late endosomal microautophagy | R-HSA-9615710 | 6.196440e-03 | 2.208 | 0 | 0 |
| Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 5.452465e-03 | 2.263 | 0 | 0 |
| SPOP-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929491 | 6.114741e-03 | 2.214 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex | R-HSA-937042 | 5.688222e-03 | 2.245 | 0 | 0 |
| Late Phase of HIV Life Cycle | R-HSA-162599 | 5.225216e-03 | 2.282 | 0 | 0 |
| Negative regulation of NOTCH4 signaling | R-HSA-9604323 | 5.262476e-03 | 2.279 | 0 | 0 |
| Hh mutants are degraded by ERAD | R-HSA-5362768 | 6.114741e-03 | 2.214 | 0 | 0 |
| Depolymerization of the Nuclear Lamina | R-HSA-4419969 | 6.329382e-03 | 2.199 | 0 | 0 |
| Downregulation of TGF-beta receptor signaling | R-HSA-2173788 | 5.262434e-03 | 2.279 | 0 | 0 |
| Signal Transduction | R-HSA-162582 | 5.949278e-03 | 2.226 | 0 | 0 |
| Host Interactions of HIV factors | R-HSA-162909 | 6.215810e-03 | 2.207 | 0 | 0 |
| Base Excision Repair | R-HSA-73884 | 6.319171e-03 | 2.199 | 0 | 0 |
| SARS-CoV-1 Infection | R-HSA-9678108 | 5.653959e-03 | 2.248 | 0 | 0 |
| Adaptive Immune System | R-HSA-1280218 | 6.667507e-03 | 2.176 | 0 | 0 |
| SCF-beta-TrCP mediated degradation of Emi1 | R-HSA-174113 | 6.773876e-03 | 2.169 | 0 | 0 |
| Maturation of protein E | R-HSA-9683683 | 7.018645e-03 | 2.154 | 0 | 0 |
| Maturation of protein E | R-HSA-9694493 | 7.018645e-03 | 2.154 | 0 | 0 |
| Formation of the canonical BAF (cBAF) complex | R-HSA-9933937 | 7.331744e-03 | 2.135 | 0 | 0 |
| RNA Polymerase III Transcription Initiation | R-HSA-76046 | 7.370448e-03 | 2.133 | 0 | 0 |
| Activation of BH3-only proteins | R-HSA-114452 | 7.370448e-03 | 2.133 | 0 | 0 |
| Influenza Infection | R-HSA-168255 | 7.397182e-03 | 2.131 | 0 | 0 |
| Oncogenic MAPK signaling | R-HSA-6802957 | 7.422120e-03 | 2.129 | 0 | 0 |
| Post-translational protein phosphorylation | R-HSA-8957275 | 7.817096e-03 | 2.107 | 0 | 0 |
| Folding of actin by CCT/TriC | R-HSA-390450 | 7.876187e-03 | 2.104 | 0 | 0 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | R-HSA-9014325 | 7.876187e-03 | 2.104 | 0 | 0 |
| Josephin domain DUBs | R-HSA-5689877 | 7.876187e-03 | 2.104 | 0 | 0 |
| Vif-mediated degradation of APOBEC3G | R-HSA-180585 | 7.906278e-03 | 2.102 | 0 | 0 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 8.020966e-03 | 2.096 | 0 | 0 |
| p53-Dependent G1/S DNA damage checkpoint | R-HSA-69580 | 8.158884e-03 | 2.088 | 0 | 0 |
| p53-Dependent G1 DNA Damage Response | R-HSA-69563 | 8.158884e-03 | 2.088 | 0 | 0 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | R-HSA-141444 | 8.187612e-03 | 2.087 | 0 | 0 |
| Amplification of signal from the kinetochores | R-HSA-141424 | 8.187612e-03 | 2.087 | 0 | 0 |
| Transcriptional and post-translational regulation of MITF-M expression and activity | R-HSA-9856649 | 8.311773e-03 | 2.080 | 0 | 0 |
| Platelet degranulation | R-HSA-114608 | 8.537760e-03 | 2.069 | 0 | 0 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | R-HSA-211733 | 8.707119e-03 | 2.060 | 0 | 0 |
| Degradation of DVL | R-HSA-4641258 | 9.179069e-03 | 2.037 | 0 | 0 |
| Signaling by high-kinase activity BRAF mutants | R-HSA-6802948 | 9.179069e-03 | 2.037 | 0 | 0 |
| Developmental Lineages of the Mammary Gland | R-HSA-9924644 | 9.238344e-03 | 2.034 | 0 | 0 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 9.238344e-03 | 2.034 | 0 | 0 |
| Hh mutants abrogate ligand secretion | R-HSA-5387390 | 9.333550e-03 | 2.030 | 0 | 0 |
| Formation of the embryonic stem cell BAF (esBAF) complex | R-HSA-9933946 | 9.394417e-03 | 2.027 | 0 | 0 |
| Translesion synthesis by REV1 | R-HSA-110312 | 9.394417e-03 | 2.027 | 0 | 0 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 9.394417e-03 | 2.027 | 0 | 0 |
| Activation of NF-kappaB in B cells | R-HSA-1169091 | 1.048013e-02 | 1.980 | 0 | 0 |
| Hedgehog ligand biogenesis | R-HSA-5358346 | 1.048013e-02 | 1.980 | 0 | 0 |
| Alpha-protein kinase 1 signaling pathway | R-HSA-9645460 | 1.058904e-02 | 1.975 | 0 | 0 |
| Loss of MECP2 binding ability to 5mC-DNA | R-HSA-9022538 | 1.178135e-02 | 1.929 | 0 | 0 |
| Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | R-HSA-9673766 | 1.178135e-02 | 1.929 | 0 | 0 |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | R-HSA-9824878 | 1.387968e-02 | 1.858 | 0 | 0 |
| Translesion synthesis by POLI | R-HSA-5656121 | 1.184070e-02 | 1.927 | 0 | 0 |
| Phosphorylation of the APC/C | R-HSA-176412 | 1.184070e-02 | 1.927 | 0 | 0 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | R-HSA-1236382 | 1.182007e-02 | 1.927 | 0 | 0 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | R-HSA-5637815 | 1.182007e-02 | 1.927 | 0 | 0 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | R-HSA-8866652 | 1.319788e-02 | 1.879 | 0 | 0 |
| Transport of the SLBP independent Mature mRNA | R-HSA-159227 | 1.192220e-02 | 1.924 | 0 | 0 |
| Transport of the SLBP Dependant Mature mRNA | R-HSA-159230 | 1.382752e-02 | 1.859 | 0 | 0 |
| GSK3B-mediated proteasomal degradation of PD-L1(CD274) | R-HSA-9929356 | 1.218833e-02 | 1.914 | 0 | 0 |
| Regulation of PTEN stability and activity | R-HSA-8948751 | 1.328151e-02 | 1.877 | 0 | 0 |
| snRNP Assembly | R-HSA-191859 | 1.137097e-02 | 1.944 | 0 | 0 |
| Metabolism of non-coding RNA | R-HSA-194441 | 1.137097e-02 | 1.944 | 0 | 0 |
| RNA Polymerase II Transcription Termination | R-HSA-73856 | 1.414641e-02 | 1.849 | 0 | 0 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | R-HSA-6781827 | 1.251541e-02 | 1.903 | 0 | 0 |
| Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | R-HSA-9954709 | 1.201714e-02 | 1.920 | 0 | 0 |
| Ribosome-associated quality control | R-HSA-9948299 | 1.211571e-02 | 1.917 | 0 | 0 |
| Formation of Incision Complex in GG-NER | R-HSA-5696395 | 1.394619e-02 | 1.856 | 0 | 0 |
| Metalloprotease DUBs | R-HSA-5689901 | 1.116327e-02 | 1.952 | 0 | 0 |
| UCH proteinases | R-HSA-5689603 | 1.378881e-02 | 1.860 | 0 | 0 |
| PTEN Regulation | R-HSA-6807070 | 1.298766e-02 | 1.886 | 0 | 0 |
| RNA Polymerase II Pre-transcription Events | R-HSA-674695 | 1.133561e-02 | 1.946 | 0 | 0 |
| Interactions of Rev with host cellular proteins | R-HSA-177243 | 1.394619e-02 | 1.856 | 0 | 0 |
| Orc1 removal from chromatin | R-HSA-68949 | 1.181717e-02 | 1.927 | 0 | 0 |
| ER to Golgi Anterograde Transport | R-HSA-199977 | 1.353032e-02 | 1.869 | 0 | 0 |
| Signaling by WNT | R-HSA-195721 | 1.081762e-02 | 1.966 | 0 | 0 |
| TNFR1-induced NF-kappa-B signaling pathway | R-HSA-5357956 | 1.319788e-02 | 1.879 | 0 | 0 |
| NF-kB is activated and signals survival | R-HSA-209560 | 1.387968e-02 | 1.858 | 0 | 0 |
| Cyclin A/B1/B2 associated events during G2/M transition | R-HSA-69273 | 1.192220e-02 | 1.924 | 0 | 0 |
| Regulation of NF-kappa B signaling | R-HSA-9758274 | 1.184070e-02 | 1.927 | 0 | 0 |
| Regulation of RUNX3 expression and activity | R-HSA-8941858 | 1.394619e-02 | 1.856 | 0 | 0 |
| Regulation of TP53 Activity through Acetylation | R-HSA-6804758 | 1.192220e-02 | 1.924 | 0 | 0 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | R-HSA-8864260 | 1.065539e-02 | 1.972 | 0 | 0 |
| TICAM1-dependent activation of IRF3/IRF7 | R-HSA-9013973 | 1.387968e-02 | 1.858 | 0 | 0 |
| Vpu mediated degradation of CD4 | R-HSA-180534 | 1.382752e-02 | 1.859 | 0 | 0 |
| p53-Independent G1/S DNA Damage Checkpoint | R-HSA-69613 | 1.211610e-02 | 1.917 | 0 | 0 |
| Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | R-HSA-69601 | 1.211610e-02 | 1.917 | 0 | 0 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | R-HSA-442742 | 1.192220e-02 | 1.924 | 0 | 0 |
| Telomere Maintenance | R-HSA-157579 | 1.423243e-02 | 1.847 | 0 | 0 |
| Inactivation of CSF3 (G-CSF) signaling | R-HSA-9705462 | 1.424485e-02 | 1.846 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | R-HSA-76066 | 1.424485e-02 | 1.846 | 0 | 0 |
| activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 1.424485e-02 | 1.846 | 0 | 0 |
| Translesion synthesis by POLK | R-HSA-5655862 | 1.470405e-02 | 1.833 | 0 | 0 |
| Base-Excision Repair, AP Site Formation | R-HSA-73929 | 1.488045e-02 | 1.827 | 0 | 0 |
| Loss of MECP2 binding ability to 5hmC-DNA | R-HSA-9022534 | 1.521914e-02 | 1.818 | 0 | 0 |
| SARS-CoV Infections | R-HSA-9679506 | 1.532178e-02 | 1.815 | 0 | 0 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 1.539018e-02 | 1.813 | 0 | 0 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | R-HSA-110313 | 1.588706e-02 | 1.799 | 0 | 0 |
| NIK-->noncanonical NF-kB signaling | R-HSA-5676590 | 1.588706e-02 | 1.799 | 0 | 0 |
| Autodegradation of the E3 ubiquitin ligase COP1 | R-HSA-349425 | 1.594913e-02 | 1.797 | 0 | 0 |
| Ubiquitin-dependent degradation of Cyclin D | R-HSA-75815 | 1.594913e-02 | 1.797 | 0 | 0 |
| Calnexin/calreticulin cycle | R-HSA-901042 | 1.594913e-02 | 1.797 | 0 | 0 |
| Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 1.628409e-02 | 1.788 | 0 | 0 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 1.628409e-02 | 1.788 | 0 | 0 |
| PCP/CE pathway | R-HSA-4086400 | 1.663506e-02 | 1.779 | 0 | 0 |
| Eukaryotic Translation Elongation | R-HSA-156842 | 1.683988e-02 | 1.774 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | R-HSA-76061 | 1.700539e-02 | 1.769 | 0 | 0 |
| G1/S DNA Damage Checkpoints | R-HSA-69615 | 1.741322e-02 | 1.759 | 0 | 0 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 1.779592e-02 | 1.750 | 0 | 0 |
| VLDLR internalisation and degradation | R-HSA-8866427 | 1.779592e-02 | 1.750 | 0 | 0 |
| MAP2K and MAPK activation | R-HSA-5674135 | 1.802146e-02 | 1.744 | 0 | 0 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 1.802146e-02 | 1.744 | 0 | 0 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 1.802146e-02 | 1.744 | 0 | 0 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 1.802146e-02 | 1.744 | 0 | 0 |
| Termination of translesion DNA synthesis | R-HSA-5656169 | 1.805948e-02 | 1.743 | 0 | 0 |
| Impaired BRCA2 binding to RAD51 | R-HSA-9709570 | 1.805948e-02 | 1.743 | 0 | 0 |
| Formation of WDR5-containing histone-modifying complexes | R-HSA-9772755 | 1.830010e-02 | 1.738 | 0 | 0 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | R-HSA-8854050 | 1.830010e-02 | 1.738 | 0 | 0 |
| Regulation of Apoptosis | R-HSA-169911 | 1.830010e-02 | 1.738 | 0 | 0 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 1.910096e-02 | 1.719 | 0 | 0 |
| Developmental Cell Lineages of the Integumentary System | R-HSA-9734779 | 1.930108e-02 | 1.714 | 0 | 0 |
| trans-Golgi Network Vesicle Budding | R-HSA-199992 | 1.969398e-02 | 1.706 | 0 | 0 |
| Maternal to zygotic transition (MZT) | R-HSA-9816359 | 1.982171e-02 | 1.703 | 0 | 0 |
| Formation of annular gap junctions | R-HSA-196025 | 2.023128e-02 | 1.694 | 0 | 0 |
| Myoclonic epilepsy of Lafora | R-HSA-3785653 | 2.023128e-02 | 1.694 | 0 | 0 |
| Downregulation of ERBB4 signaling | R-HSA-1253288 | 2.023128e-02 | 1.694 | 0 | 0 |
| Modulation by Mtb of host immune system | R-HSA-9637628 | 2.023128e-02 | 1.694 | 0 | 0 |
| SARS-CoV-2 Infection | R-HSA-9694516 | 2.074501e-02 | 1.683 | 0 | 0 |
| RNA Polymerase III Abortive And Retractive Initiation | R-HSA-749476 | 2.089311e-02 | 1.680 | 0 | 0 |
| RNA Polymerase III Transcription | R-HSA-74158 | 2.089311e-02 | 1.680 | 0 | 0 |
| Regulation of TP53 Degradation | R-HSA-6804757 | 2.089311e-02 | 1.680 | 0 | 0 |
| Epigenetic regulation by WDR5-containing histone modifying complexes | R-HSA-9917777 | 2.111203e-02 | 1.675 | 0 | 0 |
| Ephrin signaling | R-HSA-3928664 | 2.180535e-02 | 1.661 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition | R-HSA-9926550 | 2.180535e-02 | 1.661 | 0 | 0 |
| Regulation of TP53 Activity through Methylation | R-HSA-6804760 | 2.180535e-02 | 1.661 | 0 | 0 |
| Developmental Biology | R-HSA-1266738 | 2.183292e-02 | 1.661 | 0 | 0 |
| Mitotic G1 phase and G1/S transition | R-HSA-453279 | 2.190748e-02 | 1.659 | 0 | 0 |
| ER-Phagosome pathway | R-HSA-1236974 | 2.351236e-02 | 1.629 | 0 | 0 |
| Vpr-mediated nuclear import of PICs | R-HSA-180910 | 2.374045e-02 | 1.625 | 0 | 0 |
| Ovarian tumor domain proteases | R-HSA-5689896 | 2.374045e-02 | 1.625 | 0 | 0 |
| Degradation of AXIN | R-HSA-4641257 | 2.374045e-02 | 1.625 | 0 | 0 |
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | R-HSA-9762114 | 2.374045e-02 | 1.625 | 0 | 0 |
| Trafficking of AMPA receptors | R-HSA-399719 | 2.408624e-02 | 1.618 | 0 | 0 |
| Evasion by RSV of host interferon responses | R-HSA-9833109 | 2.408624e-02 | 1.618 | 0 | 0 |
| G1/S Transition | R-HSA-69206 | 2.428175e-02 | 1.615 | 0 | 0 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | R-HSA-9633012 | 2.458530e-02 | 1.609 | 0 | 0 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 2.507787e-02 | 1.601 | 0 | 0 |
| EPHB-mediated forward signaling | R-HSA-3928662 | 2.568776e-02 | 1.590 | 0 | 0 |
| Impaired BRCA2 binding to PALB2 | R-HSA-9709603 | 2.609858e-02 | 1.583 | 0 | 0 |
| Gap junction degradation | R-HSA-190873 | 2.668458e-02 | 1.574 | 0 | 0 |
| ALK mutants bind TKIs | R-HSA-9700645 | 2.668458e-02 | 1.574 | 0 | 0 |
| Rev-mediated nuclear export of HIV RNA | R-HSA-165054 | 2.685386e-02 | 1.571 | 0 | 0 |
| Formation of RNA Pol II elongation complex | R-HSA-112382 | 2.695664e-02 | 1.569 | 0 | 0 |
| Diseases of mitotic cell cycle | R-HSA-9675126 | 2.757453e-02 | 1.559 | 0 | 0 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | R-HSA-2173795 | 2.757453e-02 | 1.559 | 0 | 0 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | R-HSA-975163 | 2.766664e-02 | 1.558 | 0 | 0 |
| NRIF signals cell death from the nucleus | R-HSA-205043 | 2.766664e-02 | 1.558 | 0 | 0 |
| Loss of phosphorylation of MECP2 at T308 | R-HSA-9022535 | 2.824870e-02 | 1.549 | 0 | 0 |
| 2-LTR circle formation | R-HSA-164843 | 3.423805e-02 | 1.465 | 0 | 0 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 3.368529e-02 | 1.473 | 0 | 0 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | R-HSA-450385 | 3.368529e-02 | 1.473 | 0 | 0 |
| Class I peroxisomal membrane protein import | R-HSA-9603798 | 4.045733e-02 | 1.393 | 0 | 0 |
| Transcription of E2F targets under negative control by DREAM complex | R-HSA-1362277 | 3.091874e-02 | 1.510 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to PALB2 loss of function | R-HSA-9701193 | 3.091874e-02 | 1.510 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA1 loss of function | R-HSA-9701192 | 3.091874e-02 | 1.510 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | R-HSA-9704331 | 3.091874e-02 | 1.510 | 0 | 0 |
| Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | R-HSA-9704646 | 3.091874e-02 | 1.510 | 0 | 0 |
| PD-L1(CD274) glycosylation and translocation to plasma membrane | R-HSA-9931295 | 3.628558e-02 | 1.440 | 0 | 0 |
| Signaling by EGFR in Cancer | R-HSA-1643713 | 3.181733e-02 | 1.497 | 0 | 0 |
| Interaction between L1 and Ankyrins | R-HSA-445095 | 3.655224e-02 | 1.437 | 0 | 0 |
| RNA Polymerase I Transcription Termination | R-HSA-73863 | 3.655224e-02 | 1.437 | 0 | 0 |
| RNA Polymerase II Transcription Elongation | R-HSA-75955 | 2.983647e-02 | 1.525 | 0 | 0 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 2.973341e-02 | 1.527 | 0 | 0 |
| Regulation of PD-L1(CD274) Post-translational modification | R-HSA-9909615 | 3.269319e-02 | 1.486 | 0 | 0 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | R-HSA-2979096 | 3.628558e-02 | 1.440 | 0 | 0 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | R-HSA-937072 | 3.368529e-02 | 1.473 | 0 | 0 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 3.342034e-02 | 1.476 | 0 | 0 |
| Diseases of DNA Double-Strand Break Repair | R-HSA-9675136 | 4.009769e-02 | 1.397 | 0 | 0 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 2.869664e-02 | 1.542 | 0 | 0 |
| CaMK IV-mediated phosphorylation of CREB | R-HSA-111932 | 3.423805e-02 | 1.465 | 0 | 0 |
| Nectin/Necl trans heterodimerization | R-HSA-420597 | 2.824870e-02 | 1.549 | 0 | 0 |
| Regulation of TP53 Expression and Degradation | R-HSA-6806003 | 3.024445e-02 | 1.519 | 0 | 0 |
| Nuclear import of Rev protein | R-HSA-180746 | 4.009769e-02 | 1.397 | 0 | 0 |
| Breakdown of the nuclear lamina | R-HSA-352238 | 3.223068e-02 | 1.492 | 0 | 0 |
| Protein methylation | R-HSA-8876725 | 3.368529e-02 | 1.473 | 0 | 0 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | R-HSA-2173791 | 3.368529e-02 | 1.473 | 0 | 0 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 3.139780e-02 | 1.503 | 0 | 0 |
| HDR through Single Strand Annealing (SSA) | R-HSA-5685938 | 3.139780e-02 | 1.503 | 0 | 0 |
| Degradation of CRY and PER proteins | R-HSA-9932298 | 4.217956e-02 | 1.375 | 0 | 0 |
| Aryl hydrocarbon receptor signalling | R-HSA-8937144 | 3.943782e-02 | 1.404 | 0 | 0 |
| TAK1-dependent IKK and NF-kappa-B activation | R-HSA-445989 | 3.544863e-02 | 1.450 | 0 | 0 |
| Asymmetric localization of PCP proteins | R-HSA-4608870 | 2.869664e-02 | 1.542 | 0 | 0 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 3.139780e-02 | 1.503 | 0 | 0 |
| Neurotransmitter receptors and postsynaptic signal transmission | R-HSA-112314 | 3.092424e-02 | 1.510 | 0 | 0 |
| NS1 Mediated Effects on Host Pathways | R-HSA-168276 | 3.024445e-02 | 1.519 | 0 | 0 |
| Defective homologous recombination repair (HRR) due to BRCA2 loss of function | R-HSA-9701190 | 4.009769e-02 | 1.397 | 0 | 0 |
| Interactions of Vpr with host cellular proteins | R-HSA-176033 | 3.392264e-02 | 1.470 | 0 | 0 |
| Vesicle-mediated transport | R-HSA-5653656 | 3.688368e-02 | 1.433 | 0 | 0 |
| STAT3 nuclear events downstream of ALK signaling | R-HSA-9701898 | 3.368529e-02 | 1.473 | 0 | 0 |
| PKMTs methylate histone lysines | R-HSA-3214841 | 3.789808e-02 | 1.421 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in pigmentation | R-HSA-9824585 | 2.869664e-02 | 1.542 | 0 | 0 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 3.129884e-02 | 1.504 | 0 | 0 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | R-HSA-399721 | 3.139780e-02 | 1.503 | 0 | 0 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 3.342034e-02 | 1.476 | 0 | 0 |
| Signaling by CSF1 (M-CSF) in myeloid cells | R-HSA-9680350 | 4.009769e-02 | 1.397 | 0 | 0 |
| Transcriptional Regulation by E2F6 | R-HSA-8953750 | 3.024445e-02 | 1.519 | 0 | 0 |
| Signaling by ROBO receptors | R-HSA-376176 | 2.940988e-02 | 1.532 | 0 | 0 |
| p75NTR signals via NF-kB | R-HSA-193639 | 3.368529e-02 | 1.473 | 0 | 0 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 3.160194e-02 | 1.500 | 0 | 0 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 3.530025e-02 | 1.452 | 0 | 0 |
| IRE1alpha activates chaperones | R-HSA-381070 | 2.973341e-02 | 1.527 | 0 | 0 |
| Pexophagy | R-HSA-9664873 | 3.423805e-02 | 1.465 | 0 | 0 |
| Listeria monocytogenes entry into host cells | R-HSA-8876384 | 4.221531e-02 | 1.375 | 0 | 0 |
| Initiation of Nuclear Envelope (NE) Reformation | R-HSA-2995383 | 4.221531e-02 | 1.375 | 0 | 0 |
| Formation of a pool of free 40S subunits | R-HSA-72689 | 4.268489e-02 | 1.370 | 0 | 0 |
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 4.280018e-02 | 1.369 | 0 | 0 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | R-HSA-532668 | 4.323282e-02 | 1.364 | 0 | 0 |
| Cellular response to hypoxia | R-HSA-1234174 | 4.336408e-02 | 1.363 | 0 | 0 |
| Presynaptic phase of homologous DNA pairing and strand exchange | R-HSA-5693616 | 4.499534e-02 | 1.347 | 0 | 0 |
| Downstream TCR signaling | R-HSA-202424 | 4.723936e-02 | 1.326 | 0 | 0 |
| Signaling by CSF3 (G-CSF) | R-HSA-9674555 | 4.735956e-02 | 1.325 | 0 | 0 |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | R-HSA-9705671 | 4.774515e-02 | 1.321 | 0 | 0 |
| Disorders of Developmental Biology | R-HSA-9675151 | 4.799727e-02 | 1.319 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | R-HSA-6804114 | 4.799727e-02 | 1.319 | 0 | 0 |
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | R-HSA-936964 | 4.799727e-02 | 1.319 | 0 | 0 |
| mTORC1-mediated signalling | R-HSA-166208 | 4.872045e-02 | 1.312 | 0 | 0 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | R-HSA-9013507 | 4.872045e-02 | 1.312 | 0 | 0 |
| Transcriptional regulation by RUNX3 | R-HSA-8878159 | 4.885164e-02 | 1.311 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 4.885164e-02 | 1.311 | 0 | 0 |
| FLT3 signaling in disease | R-HSA-9682385 | 5.026988e-02 | 1.299 | 0 | 0 |
| Regulation of expression of SLITs and ROBOs | R-HSA-9010553 | 5.054577e-02 | 1.296 | 0 | 0 |
| Pre-NOTCH Transcription and Translation | R-HSA-1912408 | 5.061974e-02 | 1.296 | 0 | 0 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | R-HSA-1234176 | 5.210447e-02 | 1.283 | 0 | 0 |
| Integration of provirus | R-HSA-162592 | 5.270614e-02 | 1.278 | 0 | 0 |
| Beta-catenin independent WNT signaling | R-HSA-3858494 | 5.286281e-02 | 1.277 | 0 | 0 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | R-HSA-5619107 | 5.345190e-02 | 1.272 | 0 | 0 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | R-HSA-9687139 | 5.345190e-02 | 1.272 | 0 | 0 |
| Death Receptor Signaling | R-HSA-73887 | 5.595611e-02 | 1.252 | 0 | 0 |
| Regulation of PTEN gene transcription | R-HSA-8943724 | 5.633257e-02 | 1.249 | 0 | 0 |
| Proteasome assembly | R-HSA-9907900 | 5.693414e-02 | 1.245 | 0 | 0 |
| SCF(Skp2)-mediated degradation of p27/p21 | R-HSA-187577 | 5.693414e-02 | 1.245 | 0 | 0 |
| Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 5.881013e-02 | 1.231 | 0 | 0 |
| Developmental Lineage of Pancreatic Ductal Cells | R-HSA-9925563 | 5.966667e-02 | 1.224 | 0 | 0 |
| IP3 and IP4 transport between cytosol and nucleus | R-HSA-1855196 | 6.001289e-02 | 1.222 | 0 | 0 |
| IP6 and IP7 transport between cytosol and nucleus | R-HSA-1855229 | 6.001289e-02 | 1.222 | 0 | 0 |
| Formation of the dystrophin-glycoprotein complex (DGC) | R-HSA-9913351 | 6.001289e-02 | 1.222 | 0 | 0 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 6.197614e-02 | 1.208 | 0 | 0 |
| Homologous DNA Pairing and Strand Exchange | R-HSA-5693579 | 6.197614e-02 | 1.208 | 0 | 0 |
| Golgi Associated Vesicle Biogenesis | R-HSA-432722 | 6.210770e-02 | 1.207 | 0 | 0 |
| ABC transporter disorders | R-HSA-5619084 | 6.227413e-02 | 1.206 | 0 | 0 |
| Fanconi Anemia Pathway | R-HSA-6783310 | 6.250867e-02 | 1.204 | 0 | 0 |
| RNA Polymerase II Transcription | R-HSA-73857 | 6.327520e-02 | 1.199 | 1 | 0 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | R-HSA-8862803 | 6.348829e-02 | 1.197 | 0 | 0 |
| Neurodegenerative Diseases | R-HSA-8863678 | 6.348829e-02 | 1.197 | 0 | 0 |
| Pervasive developmental disorders | R-HSA-9005895 | 6.361212e-02 | 1.196 | 0 | 0 |
| Loss of function of MECP2 in Rett syndrome | R-HSA-9005891 | 6.361212e-02 | 1.196 | 0 | 0 |
| Disorders of Nervous System Development | R-HSA-9697154 | 6.361212e-02 | 1.196 | 0 | 0 |
| Z-decay: degradation of maternal mRNAs by zygotically expressed factors | R-HSA-9820865 | 6.361212e-02 | 1.196 | 0 | 0 |
| Constitutive Signaling by Overexpressed ERBB2 | R-HSA-9634285 | 6.361212e-02 | 1.196 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | R-HSA-2691232 | 6.361212e-02 | 1.196 | 0 | 0 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | R-HSA-2691230 | 6.361212e-02 | 1.196 | 0 | 0 |
| IRAK1 recruits IKK complex | R-HSA-937039 | 6.361212e-02 | 1.196 | 0 | 0 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | R-HSA-975144 | 6.361212e-02 | 1.196 | 0 | 0 |
| p75NTR recruits signalling complexes | R-HSA-209543 | 6.361212e-02 | 1.196 | 0 | 0 |
| PCNA-Dependent Long Patch Base Excision Repair | R-HSA-5651801 | 6.540395e-02 | 1.184 | 0 | 0 |
| Translation | R-HSA-72766 | 6.661413e-02 | 1.176 | 0 | 0 |
| DNA strand elongation | R-HSA-69190 | 6.704680e-02 | 1.174 | 0 | 0 |
| Disinhibition of SNARE formation | R-HSA-114516 | 6.745116e-02 | 1.171 | 0 | 0 |
| Recycling of eIF2:GDP | R-HSA-72731 | 6.745116e-02 | 1.171 | 0 | 0 |
| Uptake and function of diphtheria toxin | R-HSA-5336415 | 6.745116e-02 | 1.171 | 0 | 0 |
| Formation of TC-NER Pre-Incision Complex | R-HSA-6781823 | 6.841854e-02 | 1.165 | 0 | 0 |
| Regulation of TNFR1 signaling | R-HSA-5357905 | 6.841854e-02 | 1.165 | 0 | 0 |
| Export of Viral Ribonucleoproteins from Nucleus | R-HSA-168274 | 6.841854e-02 | 1.165 | 0 | 0 |
| Diseases of DNA repair | R-HSA-9675135 | 6.841854e-02 | 1.165 | 0 | 0 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | R-HSA-5693554 | 7.175728e-02 | 1.144 | 0 | 0 |
| Peptide chain elongation | R-HSA-156902 | 7.321431e-02 | 1.135 | 0 | 0 |
| Signaling by NOTCH3 | R-HSA-9012852 | 7.327444e-02 | 1.135 | 0 | 0 |
| IPs transport between nucleus and cytosol | R-HSA-1855170 | 7.455557e-02 | 1.128 | 0 | 0 |
| MAPK family signaling cascades | R-HSA-5683057 | 7.524510e-02 | 1.124 | 0 | 0 |
| Regulation of signaling by CBL | R-HSA-912631 | 7.526549e-02 | 1.123 | 0 | 0 |
| Other interleukin signaling | R-HSA-449836 | 7.526549e-02 | 1.123 | 0 | 0 |
| HDR through MMEJ (alt-NHEJ) | R-HSA-5685939 | 7.560387e-02 | 1.121 | 0 | 0 |
| Membrane binding and targetting of GAG proteins | R-HSA-174490 | 7.560387e-02 | 1.121 | 0 | 0 |
| Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 7.581218e-02 | 1.120 | 0 | 0 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 7.581218e-02 | 1.120 | 0 | 0 |
| TNF signaling | R-HSA-75893 | 7.930056e-02 | 1.101 | 0 | 0 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | R-HSA-5617472 | 7.971827e-02 | 1.098 | 0 | 0 |
| Activation of HOX genes during differentiation | R-HSA-5619507 | 7.971827e-02 | 1.098 | 0 | 0 |
| Myogenesis | R-HSA-525793 | 8.061436e-02 | 1.094 | 0 | 0 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | R-HSA-110373 | 8.061436e-02 | 1.094 | 0 | 0 |
| Activated NOTCH1 Transmits Signal to the Nucleus | R-HSA-2122948 | 8.061436e-02 | 1.094 | 0 | 0 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 8.248762e-02 | 1.084 | 0 | 0 |
| Transcriptional Regulation by VENTX | R-HSA-8853884 | 8.248762e-02 | 1.084 | 0 | 0 |
| Association of TriC/CCT with target proteins during biosynthesis | R-HSA-390471 | 8.253883e-02 | 1.083 | 0 | 0 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | R-HSA-170822 | 8.253883e-02 | 1.083 | 0 | 0 |
| Signal transduction by L1 | R-HSA-445144 | 8.588517e-02 | 1.066 | 0 | 0 |
| Negative regulation of MET activity | R-HSA-6807004 | 8.588517e-02 | 1.066 | 0 | 0 |
| APC truncation mutants are not K63 polyubiquitinated | R-HSA-5467333 | 8.860658e-02 | 1.053 | 0 | 0 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | R-HSA-174495 | 8.864478e-02 | 1.052 | 0 | 0 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | R-HSA-5684264 | 8.864478e-02 | 1.052 | 0 | 0 |
| Non-canonical inflammasome activation | R-HSA-9686114 | 8.864478e-02 | 1.052 | 0 | 0 |
| Defective Intrinsic Pathway for Apoptosis | R-HSA-9734009 | 9.005362e-02 | 1.045 | 0 | 0 |
| ER Quality Control Compartment (ERQC) | R-HSA-901032 | 9.005362e-02 | 1.045 | 0 | 0 |
| Non-integrin membrane-ECM interactions | R-HSA-3000171 | 9.098254e-02 | 1.041 | 0 | 0 |
| Signaling by NOTCH2 | R-HSA-1980145 | 9.099394e-02 | 1.041 | 0 | 0 |
| SARS-CoV-1 modulates host translation machinery | R-HSA-9735869 | 9.099394e-02 | 1.041 | 0 | 0 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 9.099394e-02 | 1.041 | 0 | 0 |
| Regulation of RAS by GAPs | R-HSA-5658442 | 9.544751e-02 | 1.020 | 0 | 0 |
| Early Phase of HIV Life Cycle | R-HSA-162594 | 9.724524e-02 | 1.012 | 0 | 0 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 9.724524e-02 | 1.012 | 0 | 0 |
| Ca-dependent events | R-HSA-111996 | 9.813960e-02 | 1.008 | 0 | 0 |
| MTOR signalling | R-HSA-165159 | 9.813960e-02 | 1.008 | 0 | 0 |
| Antigen processing-Cross presentation | R-HSA-1236975 | 9.908089e-02 | 1.004 | 0 | 0 |
| Nuclear Pore Complex (NPC) Disassembly | R-HSA-3301854 | 9.991606e-02 | 1.000 | 0 | 0 |
| PERK regulates gene expression | R-HSA-381042 | 9.991606e-02 | 1.000 | 0 | 0 |
| Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells | R-HSA-9860927 | 9.991606e-02 | 1.000 | 0 | 0 |
| Transcription of the HIV genome | R-HSA-167172 | 1.016822e-01 | 0.993 | 0 | 0 |
| Regulated Necrosis | R-HSA-5218859 | 1.016822e-01 | 0.993 | 0 | 0 |
| RAF/MAP kinase cascade | R-HSA-5673001 | 1.017228e-01 | 0.993 | 0 | 0 |
| MASTL Facilitates Mitotic Progression | R-HSA-2465910 | 1.022161e-01 | 0.990 | 0 | 0 |
| Unwinding of DNA | R-HSA-176974 | 1.022161e-01 | 0.990 | 0 | 0 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | R-HSA-450513 | 1.026882e-01 | 0.988 | 0 | 0 |
| DCC mediated attractive signaling | R-HSA-418885 | 1.026882e-01 | 0.988 | 0 | 0 |
| InlB-mediated entry of Listeria monocytogenes into host cell | R-HSA-8875360 | 1.026882e-01 | 0.988 | 0 | 0 |
| TICAM1, RIP1-mediated IKK complex recruitment | R-HSA-168927 | 1.026882e-01 | 0.988 | 0 | 0 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 1.026882e-01 | 0.988 | 0 | 0 |
| Spry regulation of FGF signaling | R-HSA-1295596 | 1.026882e-01 | 0.988 | 0 | 0 |
| Interleukin-1 signaling | R-HSA-9020702 | 1.046668e-01 | 0.980 | 0 | 0 |
| MECP2 regulates transcription of genes involved in GABA signaling | R-HSA-9022927 | 1.078226e-01 | 0.967 | 0 | 0 |
| NFE2L2 regulating ER-stress associated genes | R-HSA-9818035 | 1.078226e-01 | 0.967 | 0 | 0 |
| NADE modulates death signalling | R-HSA-205025 | 1.078226e-01 | 0.967 | 0 | 0 |
| p75NTR negatively regulates cell cycle via SC1 | R-HSA-193670 | 1.078226e-01 | 0.967 | 0 | 0 |
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | R-HSA-9818564 | 1.079654e-01 | 0.967 | 0 | 0 |
| Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | R-HSA-9851695 | 1.079654e-01 | 0.967 | 0 | 0 |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | R-HSA-9841922 | 1.079654e-01 | 0.967 | 0 | 0 |
| Potential therapeutics for SARS | R-HSA-9679191 | 1.087612e-01 | 0.964 | 0 | 0 |
| CaM pathway | R-HSA-111997 | 1.092982e-01 | 0.961 | 0 | 0 |
| Calmodulin induced events | R-HSA-111933 | 1.092982e-01 | 0.961 | 0 | 0 |
| Signaling by PDGFR in disease | R-HSA-9671555 | 1.093227e-01 | 0.961 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | R-HSA-9825892 | 1.093227e-01 | 0.961 | 0 | 0 |
| SARS-CoV-1 activates/modulates innate immune responses | R-HSA-9692916 | 1.109894e-01 | 0.955 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere | R-HSA-9670621 | 1.693668e-01 | 0.771 | 0 | 0 |
| Diseases of Telomere Maintenance | R-HSA-9673013 | 1.693668e-01 | 0.771 | 0 | 0 |
| Alternative Lengthening of Telomeres (ALT) | R-HSA-9006821 | 1.693668e-01 | 0.771 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | R-HSA-9670613 | 1.693668e-01 | 0.771 | 0 | 0 |
| Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | R-HSA-9670615 | 1.693668e-01 | 0.771 | 0 | 0 |
| SARS-CoV-1 targets PDZ proteins in cell-cell junction | R-HSA-9692912 | 1.693668e-01 | 0.771 | 0 | 0 |
| Defective DNA double strand break response due to BARD1 loss of function | R-HSA-9699150 | 1.693668e-01 | 0.771 | 0 | 0 |
| UNC93B1 deficiency - HSE | R-HSA-5602415 | 1.693668e-01 | 0.771 | 0 | 0 |
| Defective DNA double strand break response due to BRCA1 loss of function | R-HSA-9663199 | 1.693668e-01 | 0.771 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH6 | R-HSA-5632968 | 1.693668e-01 | 0.771 | 0 | 0 |
| CDH11 homotypic and heterotypic interactions | R-HSA-9833576 | 1.705839e-01 | 0.768 | 0 | 0 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | 1.705839e-01 | 0.768 | 0 | 0 |
| Loss of MECP2 binding ability to the NCoR/SMRT complex | R-HSA-9022537 | 1.705839e-01 | 0.768 | 0 | 0 |
| Positive Regulation of CDH1 Gene Transcription | R-HSA-9764790 | 1.217709e-01 | 0.914 | 0 | 0 |
| MECP2 regulates transcription of neuronal ligands | R-HSA-9022702 | 1.217709e-01 | 0.914 | 0 | 0 |
| Activation of Ca-permeable Kainate Receptor | R-HSA-451308 | 1.217709e-01 | 0.914 | 0 | 0 |
| Autointegration results in viral DNA circles | R-HSA-177539 | 2.038235e-01 | 0.691 | 0 | 0 |
| KSRP (KHSRP) binds and destabilizes mRNA | R-HSA-450604 | 1.176790e-01 | 0.929 | 0 | 0 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | R-HSA-354194 | 1.176790e-01 | 0.929 | 0 | 0 |
| Activation of RAC1 | R-HSA-428540 | 1.644236e-01 | 0.784 | 0 | 0 |
| Processing of Intronless Pre-mRNAs | R-HSA-77595 | 1.335552e-01 | 0.874 | 0 | 0 |
| Polymerase switching | R-HSA-69091 | 1.871945e-01 | 0.728 | 0 | 0 |
| Leading Strand Synthesis | R-HSA-69109 | 1.871945e-01 | 0.728 | 0 | 0 |
| Scavenging by Class F Receptors | R-HSA-3000484 | 1.871945e-01 | 0.728 | 0 | 0 |
| p130Cas linkage to MAPK signaling for integrins | R-HSA-372708 | 1.502492e-01 | 0.823 | 0 | 0 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | R-HSA-76071 | 1.220899e-01 | 0.913 | 0 | 0 |
| Notch-HLH transcription pathway | R-HSA-350054 | 1.220899e-01 | 0.913 | 0 | 0 |
| Signaling by ERBB2 ECD mutants | R-HSA-9665348 | 1.676896e-01 | 0.775 | 0 | 0 |
| Deadenylation of mRNA | R-HSA-429947 | 1.495619e-01 | 0.825 | 0 | 0 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | R-HSA-167242 | 1.858017e-01 | 0.731 | 0 | 0 |
| Lagging Strand Synthesis | R-HSA-69186 | 2.237357e-01 | 0.650 | 0 | 0 |
| NEP/NS2 Interacts with the Cellular Export Machinery | R-HSA-168333 | 1.245233e-01 | 0.905 | 0 | 0 |
| mRNA Splicing - Minor Pathway | R-HSA-72165 | 1.340673e-01 | 0.873 | 0 | 0 |
| Formation of the HIV-1 Early Elongation Complex | R-HSA-167158 | 2.111639e-01 | 0.675 | 0 | 0 |
| Formation of the Early Elongation Complex | R-HSA-113418 | 2.111639e-01 | 0.675 | 0 | 0 |
| RAF activation | R-HSA-5673000 | 1.847926e-01 | 0.733 | 0 | 0 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | R-HSA-6814122 | 1.847926e-01 | 0.733 | 0 | 0 |
| EPH-ephrin mediated repulsion of cells | R-HSA-3928665 | 1.439714e-01 | 0.842 | 0 | 0 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | R-HSA-9954716 | 1.167219e-01 | 0.933 | 0 | 0 |
| Eukaryotic Translation Termination | R-HSA-72764 | 1.230425e-01 | 0.910 | 0 | 0 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | R-HSA-9954714 | 1.446899e-01 | 0.840 | 0 | 0 |
| Transcriptional Regulation by MECP2 | R-HSA-8986944 | 1.446899e-01 | 0.840 | 0 | 0 |
| Generation of second messenger molecules | R-HSA-202433 | 1.512168e-01 | 0.820 | 0 | 0 |
| Polo-like kinase mediated events | R-HSA-156711 | 1.676896e-01 | 0.775 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | R-HSA-5358565 | 1.502492e-01 | 0.823 | 0 | 0 |
| Response of EIF2AK1 (HRI) to heme deficiency | R-HSA-9648895 | 1.355148e-01 | 0.868 | 0 | 0 |
| Sensing of DNA Double Strand Breaks | R-HSA-5693548 | 1.644236e-01 | 0.784 | 0 | 0 |
| NOTCH4 Intracellular Domain Regulates Transcription | R-HSA-9013695 | 2.237357e-01 | 0.650 | 0 | 0 |
| EGFR downregulation | R-HSA-182971 | 1.333997e-01 | 0.875 | 0 | 0 |
| Signaling by EGFR | R-HSA-177929 | 1.459890e-01 | 0.836 | 0 | 0 |
| Cellular response to starvation | R-HSA-9711097 | 2.103423e-01 | 0.677 | 0 | 0 |
| G0 and Early G1 | R-HSA-1538133 | 1.455495e-01 | 0.837 | 0 | 0 |
| Clathrin-mediated endocytosis | R-HSA-8856828 | 1.201912e-01 | 0.920 | 0 | 0 |
| Mismatch Repair | R-HSA-5358508 | 1.676896e-01 | 0.775 | 0 | 0 |
| Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 2.103423e-01 | 0.677 | 0 | 0 |
| Microbial factors inhibit CASP4 activity | R-HSA-9956593 | 2.107147e-01 | 0.676 | 0 | 0 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 1.648162e-01 | 0.783 | 0 | 0 |
| Repression of WNT target genes | R-HSA-4641265 | 1.871945e-01 | 0.728 | 0 | 0 |
| DAG and IP3 signaling | R-HSA-1489509 | 1.245233e-01 | 0.905 | 0 | 0 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 1.858330e-01 | 0.731 | 0 | 0 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 1.858330e-01 | 0.731 | 0 | 0 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 1.858330e-01 | 0.731 | 0 | 0 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 1.858330e-01 | 0.731 | 0 | 0 |
| Activation and oligomerization of BAK protein | R-HSA-111452 | 1.693668e-01 | 0.771 | 0 | 0 |
| Developmental Cell Lineages | R-HSA-9734767 | 1.988257e-01 | 0.702 | 0 | 0 |
| Nuclear events stimulated by ALK signaling in cancer | R-HSA-9725371 | 1.542250e-01 | 0.812 | 0 | 0 |
| Negative regulators of DDX58/IFIH1 signaling | R-HSA-936440 | 1.333997e-01 | 0.875 | 0 | 0 |
| Resolution of D-Loop Structures | R-HSA-5693537 | 1.712720e-01 | 0.766 | 0 | 0 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | R-HSA-5693568 | 1.581819e-01 | 0.801 | 0 | 0 |
| Neurofascin interactions | R-HSA-447043 | 2.038235e-01 | 0.691 | 0 | 0 |
| M-decay: degradation of maternal mRNAs by maternally stored factors | R-HSA-9820841 | 1.627258e-01 | 0.789 | 0 | 0 |
| Post-translational protein modification | R-HSA-597592 | 2.063589e-01 | 0.685 | 0 | 0 |
| Cargo recognition for clathrin-mediated endocytosis | R-HSA-8856825 | 1.222182e-01 | 0.913 | 0 | 0 |
| Activation, translocation and oligomerization of BAX | R-HSA-114294 | 1.693668e-01 | 0.771 | 0 | 0 |
| Inhibition of PKR | R-HSA-169131 | 1.693668e-01 | 0.771 | 0 | 0 |
| Ionotropic activity of kainate receptors | R-HSA-451306 | 1.425614e-01 | 0.846 | 0 | 0 |
| Bicarbonate transporters | R-HSA-425381 | 1.425614e-01 | 0.846 | 0 | 0 |
| Regulation of FZD by ubiquitination | R-HSA-4641263 | 1.502492e-01 | 0.823 | 0 | 0 |
| Signaling by cytosolic FGFR1 fusion mutants | R-HSA-1839117 | 1.676896e-01 | 0.775 | 0 | 0 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 1.858330e-01 | 0.731 | 0 | 0 |
| Signaling by PTK6 | R-HSA-8848021 | 1.297523e-01 | 0.887 | 0 | 0 |
| Signaling by Non-Receptor Tyrosine Kinases | R-HSA-9006927 | 1.297523e-01 | 0.887 | 0 | 0 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 1.335552e-01 | 0.874 | 0 | 0 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 2.047568e-01 | 0.689 | 0 | 0 |
| tRNA processing in the nucleus | R-HSA-6784531 | 1.216719e-01 | 0.915 | 0 | 0 |
| MAPK1/MAPK3 signaling | R-HSA-5684996 | 1.259945e-01 | 0.900 | 0 | 0 |
| Transport to the Golgi and subsequent modification | R-HSA-948021 | 1.847628e-01 | 0.733 | 0 | 0 |
| Pre-NOTCH Expression and Processing | R-HSA-1912422 | 1.270628e-01 | 0.896 | 0 | 0 |
| Epithelial-Mesenchymal Transition (EMT) during gastrulation | R-HSA-9758919 | 1.705839e-01 | 0.768 | 0 | 0 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 1.705839e-01 | 0.768 | 0 | 0 |
| PINK1-PRKN Mediated Mitophagy | R-HSA-5205685 | 2.111639e-01 | 0.675 | 0 | 0 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 2.186290e-01 | 0.660 | 0 | 0 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 2.186290e-01 | 0.660 | 0 | 0 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 2.186290e-01 | 0.660 | 0 | 0 |
| Resolution of Abasic Sites (AP sites) | R-HSA-73933 | 1.627258e-01 | 0.789 | 0 | 0 |
| Glycolysis | R-HSA-70171 | 1.575034e-01 | 0.803 | 0 | 0 |
| Regulation of MITF-M dependent genes involved in invasion | R-HSA-9854909 | 1.384100e-01 | 0.859 | 0 | 0 |
| RUNX1 regulates expression of components of tight junctions | R-HSA-8935964 | 1.705839e-01 | 0.768 | 0 | 0 |
| Integration of viral DNA into host genomic DNA | R-HSA-175567 | 2.038235e-01 | 0.691 | 0 | 0 |
| IKK complex recruitment mediated by RIP1 | R-HSA-937041 | 1.858017e-01 | 0.731 | 0 | 0 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | R-HSA-9619665 | 1.712720e-01 | 0.766 | 0 | 0 |
| Uptake and actions of bacterial toxins | R-HSA-5339562 | 1.984817e-01 | 0.702 | 0 | 0 |
| SARS-CoV-2 modulates host translation machinery | R-HSA-9754678 | 2.223521e-01 | 0.653 | 0 | 0 |
| Hemostasis | R-HSA-109582 | 1.760638e-01 | 0.754 | 0 | 0 |
| Regulation of RUNX2 expression and activity | R-HSA-8939902 | 1.138774e-01 | 0.944 | 0 | 0 |
| TP53 Regulates Transcription of Cell Cycle Genes | R-HSA-6791312 | 1.555176e-01 | 0.808 | 1 | 0 |
| Signaling by Receptor Tyrosine Kinases | R-HSA-9006934 | 1.535509e-01 | 0.814 | 0 | 0 |
| Signaling by TGFB family members | R-HSA-9006936 | 1.612023e-01 | 0.793 | 0 | 0 |
| CASP4 inflammasome assembly | R-HSA-9948001 | 1.217709e-01 | 0.914 | 0 | 0 |
| Sensory processing of sound by inner hair cells of the cochlea | R-HSA-9662360 | 1.742495e-01 | 0.759 | 0 | 0 |
| Infectious disease | R-HSA-5663205 | 1.847532e-01 | 0.733 | 0 | 0 |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | R-HSA-2892247 | 1.335552e-01 | 0.874 | 0 | 0 |
| Plasma lipoprotein clearance | R-HSA-8964043 | 1.401043e-01 | 0.854 | 0 | 0 |
| Transport of Ribonucleoproteins into the Host Nucleus | R-HSA-168271 | 1.627258e-01 | 0.789 | 0 | 0 |
| Signaling by Interleukins | R-HSA-449147 | 1.303551e-01 | 0.885 | 0 | 0 |
| KEAP1-NFE2L2 pathway | R-HSA-9755511 | 1.134567e-01 | 0.945 | 0 | 0 |
| Toxicity of botulinum toxin type C (botC) | R-HSA-5250971 | 1.384100e-01 | 0.859 | 0 | 0 |
| Regulation of CDH19 Expression and Function | R-HSA-9764302 | 1.705839e-01 | 0.768 | 0 | 0 |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | R-HSA-975110 | 1.335552e-01 | 0.874 | 0 | 0 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | R-HSA-8939243 | 1.581819e-01 | 0.801 | 0 | 0 |
| Hedgehog 'on' state | R-HSA-5632684 | 1.230121e-01 | 0.910 | 0 | 0 |
| Prevention of phagosomal-lysosomal fusion | R-HSA-9636383 | 2.237357e-01 | 0.650 | 0 | 0 |
| RMTs methylate histone arginines | R-HSA-3214858 | 2.123551e-01 | 0.673 | 0 | 0 |
| Respiratory Syncytial Virus Infection Pathway | R-HSA-9820952 | 1.929464e-01 | 0.715 | 0 | 0 |
| Response of Mtb to phagocytosis | R-HSA-9637690 | 1.994488e-01 | 0.700 | 0 | 0 |
| Nuclear events mediated by NFE2L2 | R-HSA-9759194 | 1.951509e-01 | 0.710 | 0 | 0 |
| Regulation of BACH1 activity | R-HSA-9708530 | 1.176790e-01 | 0.929 | 0 | 0 |
| Sensory processing of sound by outer hair cells of the cochlea | R-HSA-9662361 | 1.459890e-01 | 0.836 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9683701 | 1.746136e-01 | 0.758 | 0 | 0 |
| Glycogen storage diseases | R-HSA-3229121 | 1.502492e-01 | 0.823 | 0 | 0 |
| Glycogen synthesis | R-HSA-3322077 | 2.045094e-01 | 0.689 | 0 | 0 |
| Negative regulation of FLT3 | R-HSA-9706369 | 1.176790e-01 | 0.929 | 0 | 0 |
| Assembly of Viral Components at the Budding Site | R-HSA-168316 | 1.384100e-01 | 0.859 | 0 | 0 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 1.858017e-01 | 0.731 | 0 | 0 |
| mRNA Capping | R-HSA-72086 | 2.276981e-01 | 0.643 | 0 | 0 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | R-HSA-917729 | 2.276981e-01 | 0.643 | 0 | 0 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 2.298758e-01 | 0.639 | 0 | 0 |
| Signaling by ERBB4 | R-HSA-1236394 | 2.356403e-01 | 0.628 | 0 | 0 |
| MECP2 regulates transcription factors | R-HSA-9022707 | 2.376876e-01 | 0.624 | 0 | 0 |
| RUNX3 regulates WNT signaling | R-HSA-8951430 | 2.376876e-01 | 0.624 | 0 | 0 |
| Binding of TCF/LEF:CTNNB1 to target gene promoters | R-HSA-4411364 | 2.376876e-01 | 0.624 | 0 | 0 |
| CHL1 interactions | R-HSA-447041 | 2.376876e-01 | 0.624 | 0 | 0 |
| RUNX1 regulates estrogen receptor mediated transcription | R-HSA-8931987 | 2.376876e-01 | 0.624 | 0 | 0 |
| Role of ABL in ROBO-SLIT signaling | R-HSA-428890 | 2.376876e-01 | 0.624 | 0 | 0 |
| Cation-coupled Chloride cotransporters | R-HSA-426117 | 2.376876e-01 | 0.624 | 0 | 0 |
| RUNX3 Regulates Immune Response and Cell Migration | R-HSA-8949275 | 2.376876e-01 | 0.624 | 0 | 0 |
| Regulation of pyruvate metabolism | R-HSA-9861718 | 2.390360e-01 | 0.622 | 0 | 0 |
| Intracellular signaling by second messengers | R-HSA-9006925 | 2.425470e-01 | 0.615 | 0 | 0 |
| SLC-mediated transport of inorganic anions | R-HSA-9958790 | 2.425959e-01 | 0.615 | 0 | 0 |
| Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) | R-HSA-5619054 | 2.429751e-01 | 0.614 | 0 | 0 |
| PTEN Loss of Function in Cancer | R-HSA-5674404 | 2.429751e-01 | 0.614 | 0 | 0 |
| Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) | R-HSA-5619039 | 2.429751e-01 | 0.614 | 0 | 0 |
| Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) | R-HSA-5619050 | 2.429751e-01 | 0.614 | 0 | 0 |
| Defective Mismatch Repair Associated With MSH2 | R-HSA-5632928 | 2.429751e-01 | 0.614 | 0 | 0 |
| Manipulation of host energy metabolism | R-HSA-9636667 | 2.429751e-01 | 0.614 | 0 | 0 |
| Assembly Of The HIV Virion | R-HSA-175474 | 2.434040e-01 | 0.614 | 0 | 0 |
| SHC1 events in ERBB2 signaling | R-HSA-1250196 | 2.445939e-01 | 0.612 | 0 | 0 |
| Signaling by ERBB2 in Cancer | R-HSA-1227990 | 2.445939e-01 | 0.612 | 0 | 0 |
| Activation of the pre-replicative complex | R-HSA-68962 | 2.445939e-01 | 0.612 | 0 | 0 |
| Ion homeostasis | R-HSA-5578775 | 2.472102e-01 | 0.607 | 0 | 0 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 2.472102e-01 | 0.607 | 0 | 0 |
| TRIF (TICAM1)-mediated TLR4 signaling | R-HSA-937061 | 2.484279e-01 | 0.605 | 0 | 0 |
| MyD88-independent TLR4 cascade | R-HSA-166166 | 2.484279e-01 | 0.605 | 0 | 0 |
| Signaling by NOTCH1 | R-HSA-1980143 | 2.577056e-01 | 0.589 | 0 | 0 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | R-HSA-167200 | 2.578220e-01 | 0.589 | 0 | 0 |
| RAS processing | R-HSA-9648002 | 2.578220e-01 | 0.589 | 0 | 0 |
| Cross-presentation of soluble exogenous antigens (endosomes) | R-HSA-1236978 | 2.578220e-01 | 0.589 | 0 | 0 |
| Processive synthesis on the lagging strand | R-HSA-69183 | 2.593959e-01 | 0.586 | 0 | 0 |
| RNA Polymerase III Chain Elongation | R-HSA-73780 | 2.593959e-01 | 0.586 | 0 | 0 |
| Immune System | R-HSA-168256 | 2.595487e-01 | 0.586 | 0 | 0 |
| Budding and maturation of HIV virion | R-HSA-162588 | 2.618042e-01 | 0.582 | 0 | 0 |
| Developmental Lineage of Mammary Stem Cells | R-HSA-9938206 | 2.634385e-01 | 0.579 | 0 | 0 |
| Neurotoxicity of clostridium toxins | R-HSA-168799 | 2.634385e-01 | 0.579 | 0 | 0 |
| Type I hemidesmosome assembly | R-HSA-446107 | 2.718050e-01 | 0.566 | 0 | 0 |
| Formyl peptide receptors bind formyl peptides and many other ligands | R-HSA-444473 | 2.718050e-01 | 0.566 | 0 | 0 |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | R-HSA-442729 | 2.718050e-01 | 0.566 | 0 | 0 |
| Negative regulation of activity of TFAP2 (AP-2) family transcription factors | R-HSA-8866904 | 2.718050e-01 | 0.566 | 0 | 0 |
| ROBO receptors bind AKAP5 | R-HSA-9010642 | 2.718050e-01 | 0.566 | 0 | 0 |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | R-HSA-8939246 | 2.718050e-01 | 0.566 | 0 | 0 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | R-HSA-73779 | 2.732941e-01 | 0.563 | 0 | 0 |
| Formation of HIV elongation complex in the absence of HIV Tat | R-HSA-167152 | 2.732941e-01 | 0.563 | 0 | 0 |
| HIV Transcription Elongation | R-HSA-167169 | 2.732941e-01 | 0.563 | 0 | 0 |
| Tat-mediated elongation of the HIV-1 transcript | R-HSA-167246 | 2.732941e-01 | 0.563 | 0 | 0 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | R-HSA-168928 | 2.737979e-01 | 0.563 | 0 | 0 |
| Response of endothelial cells to shear stress | R-HSA-9860931 | 2.752283e-01 | 0.560 | 0 | 0 |
| HCMV Late Events | R-HSA-9610379 | 2.767028e-01 | 0.558 | 0 | 0 |
| Regulation of ornithine decarboxylase (ODC) | R-HSA-350562 | 2.792823e-01 | 0.554 | 0 | 0 |
| Constitutive Signaling by AKT1 E17K in Cancer | R-HSA-5674400 | 2.837650e-01 | 0.547 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE | R-HSA-77075 | 2.837650e-01 | 0.547 | 0 | 0 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | R-HSA-167160 | 2.837650e-01 | 0.547 | 0 | 0 |
| Syndecan interactions | R-HSA-3000170 | 2.837650e-01 | 0.547 | 0 | 0 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | R-HSA-9634638 | 2.837650e-01 | 0.547 | 0 | 0 |
| WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 2.842728e-01 | 0.546 | 0 | 0 |
| Cellular responses to mechanical stimuli | R-HSA-9855142 | 2.856747e-01 | 0.544 | 0 | 0 |
| Peroxisomal protein import | R-HSA-9033241 | 2.860377e-01 | 0.544 | 0 | 0 |
| Sensory processing of sound | R-HSA-9659379 | 2.919910e-01 | 0.535 | 0 | 0 |
| Integrin signaling | R-HSA-354192 | 2.969817e-01 | 0.527 | 0 | 0 |
| Nuclear RNA decay | R-HSA-9930044 | 2.969817e-01 | 0.527 | 0 | 0 |
| Signaling by Nuclear Receptors | R-HSA-9006931 | 3.002583e-01 | 0.523 | 0 | 0 |
| Signaling by ERBB2 TMD/JMD mutants | R-HSA-9665686 | 3.043116e-01 | 0.517 | 0 | 0 |
| Processing of Capped Intronless Pre-mRNA | R-HSA-75067 | 3.043116e-01 | 0.517 | 0 | 0 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 3.043116e-01 | 0.517 | 0 | 0 |
| RNA Polymerase II HIV Promoter Escape | R-HSA-167162 | 3.048469e-01 | 0.516 | 0 | 0 |
| HIV Transcription Initiation | R-HSA-167161 | 3.048469e-01 | 0.516 | 0 | 0 |
| RNA Polymerase II Transcription Initiation | R-HSA-75953 | 3.048469e-01 | 0.516 | 0 | 0 |
| Negative regulation of MAPK pathway | R-HSA-5675221 | 3.048469e-01 | 0.516 | 0 | 0 |
| ARMS-mediated activation | R-HSA-170984 | 3.058650e-01 | 0.514 | 0 | 0 |
| AKT phosphorylates targets in the nucleus | R-HSA-198693 | 3.058650e-01 | 0.514 | 0 | 0 |
| Hypusine synthesis from eIF5A-lysine | R-HSA-204626 | 3.058650e-01 | 0.514 | 0 | 0 |
| Calcineurin activates NFAT | R-HSA-2025928 | 3.058650e-01 | 0.514 | 0 | 0 |
| Activation of RAC1 downstream of NMDARs | R-HSA-9619229 | 3.058650e-01 | 0.514 | 0 | 0 |
| GP1b-IX-V activation signalling | R-HSA-430116 | 3.058650e-01 | 0.514 | 0 | 0 |
| Activation of the AP-1 family of transcription factors | R-HSA-450341 | 3.058650e-01 | 0.514 | 0 | 0 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | R-HSA-9013700 | 3.058650e-01 | 0.514 | 0 | 0 |
| NFE2L2 regulating MDR associated enzymes | R-HSA-9818032 | 3.058650e-01 | 0.514 | 0 | 0 |
| Respiratory syncytial virus genome replication | R-HSA-9834752 | 3.058650e-01 | 0.514 | 0 | 0 |
| Cellular response to mitochondrial stress | R-HSA-9840373 | 3.058650e-01 | 0.514 | 0 | 0 |
| Transmission across Chemical Synapses | R-HSA-112315 | 3.079562e-01 | 0.512 | 0 | 0 |
| Antigen processing: Ub, ATP-independent proteasomal degradation | R-HSA-9912633 | 3.093327e-01 | 0.510 | 0 | 0 |
| TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | R-HSA-8866910 | 3.093327e-01 | 0.510 | 0 | 0 |
| TGFBR1 LBD Mutants in Cancer | R-HSA-3656535 | 3.100644e-01 | 0.509 | 0 | 0 |
| Regulation of cortical dendrite branching | R-HSA-8985801 | 3.100644e-01 | 0.509 | 0 | 0 |
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | R-HSA-446343 | 3.100644e-01 | 0.509 | 0 | 0 |
| Stimulation of the cell death response by PAK-2p34 | R-HSA-211736 | 3.100644e-01 | 0.509 | 0 | 0 |
| ATF6B (ATF6-beta) activates chaperones | R-HSA-8874177 | 3.100644e-01 | 0.509 | 0 | 0 |
| Generic Transcription Pathway | R-HSA-212436 | 3.108385e-01 | 0.507 | 1 | 0 |
| PLC beta mediated events | R-HSA-112043 | 3.127335e-01 | 0.505 | 0 | 0 |
| Viral Messenger RNA Synthesis | R-HSA-168325 | 3.127335e-01 | 0.505 | 0 | 0 |
| MAP kinase activation | R-HSA-450294 | 3.127335e-01 | 0.505 | 0 | 0 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 3.157538e-01 | 0.501 | 0 | 0 |
| Developmental Lineage of Mammary Gland Luminal Epithelial Cells | R-HSA-9927418 | 3.208631e-01 | 0.494 | 0 | 0 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | R-HSA-512988 | 3.208631e-01 | 0.494 | 0 | 0 |
| Neurexins and neuroligins | R-HSA-6794361 | 3.243403e-01 | 0.489 | 0 | 0 |
| Formation of the nephric duct | R-HSA-9830364 | 3.250090e-01 | 0.488 | 0 | 0 |
| HDMs demethylate histones | R-HSA-3214842 | 3.250090e-01 | 0.488 | 0 | 0 |
| VEGFR2 mediated cell proliferation | R-HSA-5218921 | 3.250090e-01 | 0.488 | 0 | 0 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 3.256181e-01 | 0.487 | 0 | 0 |
| Mitophagy | R-HSA-5205647 | 3.328633e-01 | 0.478 | 0 | 0 |
| NPAS4 regulates expression of target genes | R-HSA-9768919 | 3.328633e-01 | 0.478 | 0 | 0 |
| Glucose metabolism | R-HSA-70326 | 3.344383e-01 | 0.476 | 0 | 0 |
| Signaling by EGFRvIII in Cancer | R-HSA-5637812 | 3.344570e-01 | 0.476 | 0 | 0 |
| Constitutive Signaling by EGFRvIII | R-HSA-5637810 | 3.344570e-01 | 0.476 | 0 | 0 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | R-HSA-5358606 | 3.344570e-01 | 0.476 | 0 | 0 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 3.359549e-01 | 0.474 | 0 | 0 |
| RNA Polymerase II Promoter Escape | R-HSA-73776 | 3.369968e-01 | 0.472 | 0 | 0 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 3.394026e-01 | 0.469 | 0 | 0 |
| Erythropoietin activates Phospholipase C gamma (PLCG) | R-HSA-9027277 | 3.396102e-01 | 0.469 | 0 | 0 |
| EGFR Transactivation by Gastrin | R-HSA-2179392 | 3.396102e-01 | 0.469 | 0 | 0 |
| Regulation of CDH11 function | R-HSA-9762292 | 3.396102e-01 | 0.469 | 0 | 0 |
| Formation of intermediate mesoderm | R-HSA-9761174 | 3.396102e-01 | 0.469 | 0 | 0 |
| Interleukin-27 signaling | R-HSA-9020956 | 3.396102e-01 | 0.469 | 0 | 0 |
| Assembly and release of respiratory syncytial virus (RSV) virions | R-HSA-9820962 | 3.396102e-01 | 0.469 | 0 | 0 |
| MECP2 regulates neuronal receptors and channels | R-HSA-9022699 | 3.457910e-01 | 0.461 | 0 | 0 |
| Postmitotic nuclear pore complex (NPC) reformation | R-HSA-9615933 | 3.457910e-01 | 0.461 | 0 | 0 |
| Signaling by FLT3 fusion proteins | R-HSA-9703465 | 3.457910e-01 | 0.461 | 0 | 0 |
| Suppression of phagosomal maturation | R-HSA-9637687 | 3.457910e-01 | 0.461 | 0 | 0 |
| Selenocysteine synthesis | R-HSA-2408557 | 3.482124e-01 | 0.458 | 0 | 0 |
| Oncogene Induced Senescence | R-HSA-2559585 | 3.509575e-01 | 0.455 | 0 | 0 |
| Netrin-1 signaling | R-HSA-373752 | 3.532171e-01 | 0.452 | 0 | 0 |
| Cyclin D associated events in G1 | R-HSA-69231 | 3.532171e-01 | 0.452 | 0 | 0 |
| G1 Phase | R-HSA-69236 | 3.532171e-01 | 0.452 | 0 | 0 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | R-HSA-166058 | 3.544511e-01 | 0.450 | 0 | 0 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 3.544511e-01 | 0.450 | 0 | 0 |
| RNA Polymerase III Transcription Termination | R-HSA-73980 | 3.595366e-01 | 0.444 | 0 | 0 |
| GAB1 signalosome | R-HSA-180292 | 3.595366e-01 | 0.444 | 0 | 0 |
| Synaptic adhesion-like molecules | R-HSA-8849932 | 3.595366e-01 | 0.444 | 0 | 0 |
| Neutrophil degranulation | R-HSA-6798695 | 3.634205e-01 | 0.440 | 0 | 0 |
| Iron uptake and transport | R-HSA-917937 | 3.656254e-01 | 0.437 | 0 | 0 |
| Tat-mediated HIV elongation arrest and recovery | R-HSA-167243 | 3.665950e-01 | 0.436 | 0 | 0 |
| Cristae formation | R-HSA-8949613 | 3.665950e-01 | 0.436 | 0 | 0 |
| Pausing and recovery of Tat-mediated HIV elongation | R-HSA-167238 | 3.665950e-01 | 0.436 | 0 | 0 |
| Insulin processing | R-HSA-264876 | 3.665950e-01 | 0.436 | 0 | 0 |
| Mitochondrial unfolded protein response (UPRmt) | R-HSA-9841251 | 3.665950e-01 | 0.436 | 0 | 0 |
| Lysosome Vesicle Biogenesis | R-HSA-432720 | 3.690977e-01 | 0.433 | 0 | 0 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | R-HSA-76042 | 3.694935e-01 | 0.432 | 0 | 0 |
| Somitogenesis | R-HSA-9824272 | 3.694935e-01 | 0.432 | 0 | 0 |
| Viral mRNA Translation | R-HSA-192823 | 3.701568e-01 | 0.432 | 0 | 0 |
| Negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 3.712118e-01 | 0.430 | 0 | 0 |
| Axonal growth stimulation | R-HSA-209563 | 3.712118e-01 | 0.430 | 0 | 0 |
| Defective ABCC2 causes DJS | R-HSA-5679001 | 3.712118e-01 | 0.430 | 0 | 0 |
| Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | R-HSA-9944997 | 3.712118e-01 | 0.430 | 0 | 0 |
| Loss of Function of KMT2D in Kabuki Syndrome | R-HSA-9944971 | 3.712118e-01 | 0.430 | 0 | 0 |
| MET interacts with TNS proteins | R-HSA-8875513 | 3.712118e-01 | 0.430 | 0 | 0 |
| Diseases of Mismatch Repair (MMR) | R-HSA-5423599 | 3.712118e-01 | 0.430 | 0 | 0 |
| CASP5-mediated substrate cleavage | R-HSA-9960525 | 3.712118e-01 | 0.430 | 0 | 0 |
| CASP4-mediated substrate cleavage | R-HSA-9960519 | 3.712118e-01 | 0.430 | 0 | 0 |
| FasL/ CD95L signaling | R-HSA-75157 | 3.712118e-01 | 0.430 | 0 | 0 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 3.728291e-01 | 0.428 | 0 | 0 |
| Synthesis of PI | R-HSA-1483226 | 3.728291e-01 | 0.428 | 0 | 0 |
| vRNP Assembly | R-HSA-192905 | 3.728291e-01 | 0.428 | 0 | 0 |
| Suppression of apoptosis | R-HSA-9635465 | 3.728291e-01 | 0.428 | 0 | 0 |
| PECAM1 interactions | R-HSA-210990 | 3.728291e-01 | 0.428 | 0 | 0 |
| CD163 mediating an anti-inflammatory response | R-HSA-9662834 | 3.728291e-01 | 0.428 | 0 | 0 |
| LGI-ADAM interactions | R-HSA-5682910 | 3.728291e-01 | 0.428 | 0 | 0 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 3.778956e-01 | 0.423 | 0 | 0 |
| Antigen processing: Ubiquitination & Proteasome degradation | R-HSA-983168 | 3.780804e-01 | 0.422 | 0 | 0 |
| Rap1 signalling | R-HSA-392517 | 3.844727e-01 | 0.415 | 0 | 0 |
| Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | R-HSA-9856532 | 3.844727e-01 | 0.415 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9694631 | 3.844727e-01 | 0.415 | 0 | 0 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 3.848350e-01 | 0.415 | 0 | 0 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 3.848350e-01 | 0.415 | 0 | 0 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 3.872436e-01 | 0.412 | 0 | 0 |
| HIV elongation arrest and recovery | R-HSA-167287 | 3.873616e-01 | 0.412 | 0 | 0 |
| Pausing and recovery of HIV elongation | R-HSA-167290 | 3.873616e-01 | 0.412 | 0 | 0 |
| Activation of kainate receptors upon glutamate binding | R-HSA-451326 | 3.873616e-01 | 0.412 | 0 | 0 |
| Phase 0 - rapid depolarisation | R-HSA-5576892 | 3.873616e-01 | 0.412 | 0 | 0 |
| Negative regulation of FGFR3 signaling | R-HSA-5654732 | 3.873616e-01 | 0.412 | 0 | 0 |
| RNA polymerase II transcribes snRNA genes | R-HSA-6807505 | 3.880131e-01 | 0.411 | 0 | 0 |
| Translation of Structural Proteins | R-HSA-9694635 | 3.915168e-01 | 0.407 | 0 | 0 |
| RSV-host interactions | R-HSA-9833110 | 3.922688e-01 | 0.406 | 0 | 0 |
| G-protein mediated events | R-HSA-112040 | 3.950628e-01 | 0.403 | 0 | 0 |
| Condensation of Prometaphase Chromosomes | R-HSA-2514853 | 4.053499e-01 | 0.392 | 0 | 0 |
| POLB-Dependent Long Patch Base Excision Repair | R-HSA-110362 | 4.053499e-01 | 0.392 | 0 | 0 |
| Reduction of cytosolic Ca++ levels | R-HSA-418359 | 4.053499e-01 | 0.392 | 0 | 0 |
| APOBEC3G mediated resistance to HIV-1 infection | R-HSA-180689 | 4.053499e-01 | 0.392 | 0 | 0 |
| Cytochrome c-mediated apoptotic response | R-HSA-111461 | 4.053499e-01 | 0.392 | 0 | 0 |
| NFE2L2 regulates pentose phosphate pathway genes | R-HSA-9818028 | 4.053499e-01 | 0.392 | 0 | 0 |
| Regulation of gene expression by Hypoxia-inducible Factor | R-HSA-1234158 | 4.053499e-01 | 0.392 | 0 | 0 |
| Metabolism of nitric oxide: NOS3 activation and regulation | R-HSA-202131 | 4.053569e-01 | 0.392 | 0 | 0 |
| Signaling by ERBB2 KD Mutants | R-HSA-9664565 | 4.080354e-01 | 0.389 | 0 | 0 |
| Platelet calcium homeostasis | R-HSA-418360 | 4.080354e-01 | 0.389 | 0 | 0 |
| Negative regulation of FGFR4 signaling | R-HSA-5654733 | 4.080354e-01 | 0.389 | 0 | 0 |
| Formation of ATP by chemiosmotic coupling | R-HSA-163210 | 4.091763e-01 | 0.388 | 0 | 0 |
| Co-inhibition by CTLA4 | R-HSA-389513 | 4.091763e-01 | 0.388 | 0 | 0 |
| Protein hydroxylation | R-HSA-9629569 | 4.091763e-01 | 0.388 | 0 | 0 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 4.097474e-01 | 0.387 | 0 | 0 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 4.097474e-01 | 0.387 | 0 | 0 |
| Interleukin-1 family signaling | R-HSA-446652 | 4.113287e-01 | 0.386 | 0 | 0 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 4.231736e-01 | 0.373 | 0 | 0 |
| Signaling by ALK | R-HSA-201556 | 4.234009e-01 | 0.373 | 0 | 0 |
| SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 4.255915e-01 | 0.371 | 0 | 0 |
| Alternative complement activation | R-HSA-173736 | 4.269431e-01 | 0.370 | 0 | 0 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 4.269431e-01 | 0.370 | 0 | 0 |
| Defective LFNG causes SCDO3 | R-HSA-5083630 | 4.269431e-01 | 0.370 | 0 | 0 |
| TLR3-mediated TICAM1-dependent programmed cell death | R-HSA-9013957 | 4.269431e-01 | 0.370 | 0 | 0 |
| TNFR1-mediated ceramide production | R-HSA-5626978 | 4.269431e-01 | 0.370 | 0 | 0 |
| SARS-CoV-2 targets PDZ proteins in cell-cell junction | R-HSA-9705677 | 4.269431e-01 | 0.370 | 0 | 0 |
| AKT-mediated inactivation of FOXO1A | R-HSA-211163 | 4.269431e-01 | 0.370 | 0 | 0 |
| NOTCH3 Intracellular Domain Regulates Transcription | R-HSA-9013508 | 4.285650e-01 | 0.368 | 0 | 0 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 4.335678e-01 | 0.363 | 0 | 0 |
| Interleukin-17 signaling | R-HSA-448424 | 4.365887e-01 | 0.360 | 0 | 0 |
| NOTCH2 intracellular domain regulates transcription | R-HSA-2197563 | 4.370356e-01 | 0.359 | 0 | 0 |
| AKT phosphorylates targets in the cytosol | R-HSA-198323 | 4.370356e-01 | 0.359 | 0 | 0 |
| Trafficking and processing of endosomal TLR | R-HSA-1679131 | 4.370356e-01 | 0.359 | 0 | 0 |
| Interleukin-35 Signalling | R-HSA-8984722 | 4.370356e-01 | 0.359 | 0 | 0 |
| Regulation of IFNG signaling | R-HSA-877312 | 4.370356e-01 | 0.359 | 0 | 0 |
| Reversal of alkylation damage by DNA dioxygenases | R-HSA-73943 | 4.370356e-01 | 0.359 | 0 | 0 |
| Metabolism of proteins | R-HSA-392499 | 4.378646e-01 | 0.359 | 0 | 0 |
| Diseases of Immune System | R-HSA-5260271 | 4.413411e-01 | 0.355 | 0 | 0 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 4.413411e-01 | 0.355 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | R-HSA-9844594 | 4.413411e-01 | 0.355 | 0 | 0 |
| Transcriptional regulation of brown and beige adipocyte differentiation | R-HSA-9843743 | 4.413411e-01 | 0.355 | 0 | 0 |
| Nuclear signaling by ERBB4 | R-HSA-1251985 | 4.413411e-01 | 0.355 | 0 | 0 |
| Glycogen metabolism | R-HSA-8982491 | 4.413411e-01 | 0.355 | 0 | 0 |
| Molecules associated with elastic fibres | R-HSA-2129379 | 4.489027e-01 | 0.348 | 0 | 0 |
| Formation of paraxial mesoderm | R-HSA-9793380 | 4.580717e-01 | 0.339 | 0 | 0 |
| FLT3 Signaling | R-HSA-9607240 | 4.591451e-01 | 0.338 | 0 | 0 |
| PIP3 activates AKT signaling | R-HSA-1257604 | 4.676065e-01 | 0.330 | 0 | 0 |
| CREB1 phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 4.677789e-01 | 0.330 | 0 | 0 |
| Formation of axial mesoderm | R-HSA-9796292 | 4.677789e-01 | 0.330 | 0 | 0 |
| Golgi Cisternae Pericentriolar Stack Reorganization | R-HSA-162658 | 4.677789e-01 | 0.330 | 0 | 0 |
| Interleukin-6 signaling | R-HSA-1059683 | 4.677789e-01 | 0.330 | 0 | 0 |
| Maturation of nucleoprotein | R-HSA-9683610 | 4.677789e-01 | 0.330 | 0 | 0 |
| Regulation of TP53 Activity through Association with Co-factors | R-HSA-6804759 | 4.677789e-01 | 0.330 | 0 | 0 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 4.731370e-01 | 0.325 | 0 | 0 |
| Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | R-HSA-9673768 | 4.777377e-01 | 0.321 | 0 | 0 |
| Activation of C3 and C5 | R-HSA-174577 | 4.777377e-01 | 0.321 | 0 | 0 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 4.777377e-01 | 0.321 | 0 | 0 |
| Toxicity of botulinum toxin type G (botG) | R-HSA-5250989 | 4.777377e-01 | 0.321 | 0 | 0 |
| Loss of Function of TGFBR1 in Cancer | R-HSA-3656534 | 4.777377e-01 | 0.321 | 0 | 0 |
| SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | R-HSA-111464 | 4.777377e-01 | 0.321 | 0 | 0 |
| SMAC (DIABLO) binds to IAPs | R-HSA-111463 | 4.777377e-01 | 0.321 | 0 | 0 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 4.777377e-01 | 0.321 | 0 | 0 |
| PTK6 Regulates Proteins Involved in RNA Processing | R-HSA-8849468 | 4.777377e-01 | 0.321 | 0 | 0 |
| FGFR2 alternative splicing | R-HSA-6803529 | 4.811428e-01 | 0.318 | 0 | 0 |
| Regulation of IFNA/IFNB signaling | R-HSA-912694 | 4.811428e-01 | 0.318 | 0 | 0 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | R-HSA-9670439 | 4.811428e-01 | 0.318 | 0 | 0 |
| Signaling by KIT in disease | R-HSA-9669938 | 4.811428e-01 | 0.318 | 0 | 0 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | R-HSA-6804115 | 4.811428e-01 | 0.318 | 1 | 1 |
| G-protein beta:gamma signalling | R-HSA-397795 | 4.888317e-01 | 0.311 | 0 | 0 |
| FGFR1 mutant receptor activation | R-HSA-1839124 | 4.888317e-01 | 0.311 | 0 | 0 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 4.888317e-01 | 0.311 | 0 | 0 |
| Negative regulation of FGFR1 signaling | R-HSA-5654726 | 4.888317e-01 | 0.311 | 0 | 0 |
| Protein-protein interactions at synapses | R-HSA-6794362 | 4.947177e-01 | 0.306 | 0 | 0 |
| Removal of the Flap Intermediate | R-HSA-69166 | 4.974979e-01 | 0.303 | 0 | 0 |
| Regulation of CDH1 mRNA translation by microRNAs | R-HSA-9764562 | 4.974979e-01 | 0.303 | 0 | 0 |
| Regulation of KIT signaling | R-HSA-1433559 | 4.974979e-01 | 0.303 | 0 | 0 |
| Beta oxidation of hexanoyl-CoA to butanoyl-CoA | R-HSA-77350 | 4.974979e-01 | 0.303 | 0 | 0 |
| Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | R-HSA-77310 | 4.974979e-01 | 0.303 | 0 | 0 |
| Beta oxidation of octanoyl-CoA to hexanoyl-CoA | R-HSA-77348 | 4.974979e-01 | 0.303 | 0 | 0 |
| Malate-aspartate shuttle | R-HSA-9856872 | 4.974979e-01 | 0.303 | 0 | 0 |
| Signal regulatory protein family interactions | R-HSA-391160 | 4.974979e-01 | 0.303 | 0 | 0 |
| Acyl chain remodeling of CL | R-HSA-1482798 | 4.974979e-01 | 0.303 | 0 | 0 |
| G beta:gamma signalling through PI3Kgamma | R-HSA-392451 | 5.042117e-01 | 0.297 | 0 | 0 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 5.230559e-01 | 0.281 | 0 | 0 |
| Inhibition of Signaling by Overexpressed EGFR | R-HSA-5638303 | 5.240328e-01 | 0.281 | 0 | 0 |
| Signaling by Overexpressed Wild-Type EGFR in Cancer | R-HSA-5638302 | 5.240328e-01 | 0.281 | 0 | 0 |
| Phosphorylation of Emi1 | R-HSA-176417 | 5.240328e-01 | 0.281 | 0 | 0 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | 5.240328e-01 | 0.281 | 0 | 0 |
| PKA-mediated phosphorylation of key metabolic factors | R-HSA-163358 | 5.240328e-01 | 0.281 | 0 | 0 |
| Toxicity of botulinum toxin type E (botE) | R-HSA-5250992 | 5.240328e-01 | 0.281 | 0 | 0 |
| Cam-PDE 1 activation | R-HSA-111957 | 5.240328e-01 | 0.281 | 0 | 0 |
| Noncanonical activation of NOTCH3 | R-HSA-9017802 | 5.240328e-01 | 0.281 | 0 | 0 |
| Activation of caspases through apoptosome-mediated cleavage | R-HSA-111459 | 5.240328e-01 | 0.281 | 0 | 0 |
| SMAC, XIAP-regulated apoptotic response | R-HSA-111469 | 5.240328e-01 | 0.281 | 0 | 0 |
| Sodium-coupled phosphate cotransporters | R-HSA-427652 | 5.240328e-01 | 0.281 | 0 | 0 |
| Orexin and neuropeptides FF and QRFP bind to their respective receptors | R-HSA-389397 | 5.240328e-01 | 0.281 | 0 | 0 |
| TRAIL signaling | R-HSA-75158 | 5.240328e-01 | 0.281 | 0 | 0 |
| TYSND1 cleaves peroxisomal proteins | R-HSA-9033500 | 5.240328e-01 | 0.281 | 0 | 0 |
| ERBB2 Regulates Cell Motility | R-HSA-6785631 | 5.261328e-01 | 0.279 | 0 | 0 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 5.261328e-01 | 0.279 | 0 | 0 |
| p38MAPK events | R-HSA-171007 | 5.261328e-01 | 0.279 | 0 | 0 |
| DNA Damage Reversal | R-HSA-73942 | 5.261328e-01 | 0.279 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 1 | R-HSA-418592 | 5.267386e-01 | 0.278 | 0 | 0 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 5.267386e-01 | 0.278 | 0 | 0 |
| eNOS activation | R-HSA-203615 | 5.275196e-01 | 0.278 | 0 | 0 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 5.275196e-01 | 0.278 | 0 | 0 |
| Negative regulation of FGFR2 signaling | R-HSA-5654727 | 5.275196e-01 | 0.278 | 0 | 0 |
| G alpha (z) signalling events | R-HSA-418597 | 5.293859e-01 | 0.276 | 0 | 0 |
| Pyruvate metabolism | R-HSA-70268 | 5.323484e-01 | 0.274 | 0 | 0 |
| Interferon alpha/beta signaling | R-HSA-909733 | 5.352225e-01 | 0.271 | 0 | 0 |
| NRAGE signals death through JNK | R-HSA-193648 | 5.445776e-01 | 0.264 | 0 | 0 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 5.451330e-01 | 0.263 | 0 | 0 |
| Signalling to ERKs | R-HSA-187687 | 5.463201e-01 | 0.263 | 0 | 0 |
| Polymerase switching on the C-strand of the telomere | R-HSA-174411 | 5.486857e-01 | 0.261 | 0 | 0 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 5.486857e-01 | 0.261 | 0 | 0 |
| TGFBR3 expression | R-HSA-9839394 | 5.486857e-01 | 0.261 | 0 | 0 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | R-HSA-1362300 | 5.536421e-01 | 0.257 | 0 | 0 |
| Prolonged ERK activation events | R-HSA-169893 | 5.536421e-01 | 0.257 | 0 | 0 |
| Activation of SMO | R-HSA-5635838 | 5.536421e-01 | 0.257 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | R-HSA-6804116 | 5.536421e-01 | 0.257 | 0 | 0 |
| Atorvastatin ADME | R-HSA-9754706 | 5.536421e-01 | 0.257 | 0 | 0 |
| Virus Assembly and Release | R-HSA-168268 | 5.536421e-01 | 0.257 | 0 | 0 |
| Inactivation, recovery and regulation of the phototransduction cascade | R-HSA-2514859 | 5.615564e-01 | 0.251 | 0 | 0 |
| Signaling by TGFBR3 | R-HSA-9839373 | 5.615564e-01 | 0.251 | 0 | 0 |
| RET signaling | R-HSA-8853659 | 5.647238e-01 | 0.248 | 0 | 0 |
| G1/S-Specific Transcription | R-HSA-69205 | 5.647238e-01 | 0.248 | 0 | 0 |
| PTK6 promotes HIF1A stabilization | R-HSA-8857538 | 5.662267e-01 | 0.247 | 0 | 0 |
| Signaling by LTK in cancer | R-HSA-9842640 | 5.662267e-01 | 0.247 | 0 | 0 |
| Erythropoietin activates STAT5 | R-HSA-9027283 | 5.662267e-01 | 0.247 | 0 | 0 |
| RUNX3 regulates YAP1-mediated transcription | R-HSA-8951671 | 5.662267e-01 | 0.247 | 0 | 0 |
| Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | R-HSA-5619070 | 5.662267e-01 | 0.247 | 0 | 0 |
| Toxicity of botulinum toxin type F (botF) | R-HSA-5250981 | 5.662267e-01 | 0.247 | 0 | 0 |
| Toxicity of botulinum toxin type D (botD) | R-HSA-5250955 | 5.662267e-01 | 0.247 | 0 | 0 |
| G2/M DNA replication checkpoint | R-HSA-69478 | 5.662267e-01 | 0.247 | 0 | 0 |
| Abacavir transmembrane transport | R-HSA-2161517 | 5.662267e-01 | 0.247 | 0 | 0 |
| CREB phosphorylation | R-HSA-199920 | 5.662267e-01 | 0.247 | 0 | 0 |
| HDL clearance | R-HSA-8964011 | 5.662267e-01 | 0.247 | 0 | 0 |
| VLDL assembly | R-HSA-8866423 | 5.662267e-01 | 0.247 | 0 | 0 |
| Nef and signal transduction | R-HSA-164944 | 5.662267e-01 | 0.247 | 0 | 0 |
| Signaling by TGF-beta Receptor Complex in Cancer | R-HSA-3304351 | 5.662267e-01 | 0.247 | 0 | 0 |
| Interferon gamma signaling | R-HSA-877300 | 5.752308e-01 | 0.240 | 0 | 0 |
| Transcriptional regulation by RUNX2 | R-HSA-8878166 | 5.772402e-01 | 0.239 | 0 | 0 |
| G beta:gamma signalling through CDC42 | R-HSA-8964616 | 5.800005e-01 | 0.237 | 0 | 0 |
| Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | R-HSA-77346 | 5.800005e-01 | 0.237 | 0 | 0 |
| Cellular response to chemical stress | R-HSA-9711123 | 5.824616e-01 | 0.235 | 0 | 0 |
| Gastrulation | R-HSA-9758941 | 5.847582e-01 | 0.233 | 0 | 0 |
| Extension of Telomeres | R-HSA-180786 | 5.887706e-01 | 0.230 | 0 | 0 |
| Deadenylation-dependent mRNA decay | R-HSA-429914 | 5.887706e-01 | 0.230 | 0 | 0 |
| Disorders of transmembrane transporters | R-HSA-5619115 | 5.896907e-01 | 0.229 | 0 | 0 |
| Processive synthesis on the C-strand of the telomere | R-HSA-174414 | 5.907216e-01 | 0.229 | 0 | 0 |
| NGF-stimulated transcription | R-HSA-9031628 | 5.934748e-01 | 0.227 | 0 | 0 |
| Inositol phosphate metabolism | R-HSA-1483249 | 5.994285e-01 | 0.222 | 0 | 0 |
| Elastic fibre formation | R-HSA-1566948 | 6.002573e-01 | 0.222 | 0 | 0 |
| Transcriptional regulation of pluripotent stem cells | R-HSA-452723 | 6.002573e-01 | 0.222 | 0 | 0 |
| Plasma lipoprotein assembly, remodeling, and clearance | R-HSA-174824 | 6.042234e-01 | 0.219 | 0 | 0 |
| Late SARS-CoV-2 Infection Events | R-HSA-9772573 | 6.042234e-01 | 0.219 | 0 | 0 |
| Regulation of actin dynamics for phagocytic cup formation | R-HSA-2029482 | 6.042706e-01 | 0.219 | 0 | 0 |
| SLBP independent Processing of Histone Pre-mRNAs | R-HSA-111367 | 6.046823e-01 | 0.218 | 0 | 0 |
| Pre-NOTCH Processing in the Endoplasmic Reticulum | R-HSA-1912399 | 6.046823e-01 | 0.218 | 0 | 0 |
| SHOC2 M1731 mutant abolishes MRAS complex function | R-HSA-9726840 | 6.046823e-01 | 0.218 | 0 | 0 |
| Insulin effects increased synthesis of Xylulose-5-Phosphate | R-HSA-163754 | 6.046823e-01 | 0.218 | 0 | 0 |
| PTK6 Expression | R-HSA-8849473 | 6.046823e-01 | 0.218 | 0 | 0 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 6.046823e-01 | 0.218 | 0 | 0 |
| NOSTRIN mediated eNOS trafficking | R-HSA-203641 | 6.046823e-01 | 0.218 | 0 | 0 |
| VLDL clearance | R-HSA-8964046 | 6.046823e-01 | 0.218 | 0 | 0 |
| LDL remodeling | R-HSA-8964041 | 6.046823e-01 | 0.218 | 0 | 0 |
| TGFBR3 regulates TGF-beta signaling | R-HSA-9839389 | 6.046823e-01 | 0.218 | 0 | 0 |
| Microbial modulation of RIPK1-mediated regulated necrosis | R-HSA-9686347 | 6.046823e-01 | 0.218 | 0 | 0 |
| Displacement of DNA glycosylase by APEX1 | R-HSA-110357 | 6.046823e-01 | 0.218 | 0 | 0 |
| Removal of the Flap Intermediate from the C-strand | R-HSA-174437 | 6.051958e-01 | 0.218 | 0 | 0 |
| Elevation of cytosolic Ca2+ levels | R-HSA-139853 | 6.051958e-01 | 0.218 | 0 | 0 |
| Modulation of host responses by IFN-stimulated genes | R-HSA-9909505 | 6.051958e-01 | 0.218 | 0 | 0 |
| ATF4 activates genes in response to endoplasmic reticulum stress | R-HSA-380994 | 6.107664e-01 | 0.214 | 0 | 0 |
| Insulin receptor recycling | R-HSA-77387 | 6.107664e-01 | 0.214 | 0 | 0 |
| Pyroptosis | R-HSA-5620971 | 6.107664e-01 | 0.214 | 0 | 0 |
| Nuclear Events (kinase and transcription factor activation) | R-HSA-198725 | 6.116211e-01 | 0.214 | 0 | 0 |
| Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | R-HSA-9725554 | 6.173533e-01 | 0.209 | 0 | 0 |
| Respiratory syncytial virus (RSV) genome replication, transcription and translation | R-HSA-9820965 | 6.173533e-01 | 0.209 | 0 | 0 |
| Protein localization | R-HSA-9609507 | 6.207528e-01 | 0.207 | 0 | 0 |
| Opioid Signalling | R-HSA-111885 | 6.232539e-01 | 0.205 | 0 | 0 |
| Ca2+ pathway | R-HSA-4086398 | 6.244135e-01 | 0.205 | 0 | 0 |
| Cytosolic iron-sulfur cluster assembly | R-HSA-2564830 | 6.292271e-01 | 0.201 | 0 | 0 |
| PKA activation | R-HSA-163615 | 6.292271e-01 | 0.201 | 0 | 0 |
| Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 6.292271e-01 | 0.201 | 0 | 0 |
| Serotonin Neurotransmitter Release Cycle | R-HSA-181429 | 6.292271e-01 | 0.201 | 0 | 0 |
| Platelet sensitization by LDL | R-HSA-432142 | 6.292271e-01 | 0.201 | 0 | 0 |
| Apoptotic factor-mediated response | R-HSA-111471 | 6.292271e-01 | 0.201 | 0 | 0 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 6.292271e-01 | 0.201 | 0 | 0 |
| Nephron development | R-HSA-9831926 | 6.292271e-01 | 0.201 | 0 | 0 |
| DARPP-32 events | R-HSA-180024 | 6.301421e-01 | 0.201 | 0 | 0 |
| Regulation of CDH11 Expression and Function | R-HSA-9759475 | 6.301421e-01 | 0.201 | 0 | 0 |
| MAPK targets/ Nuclear events mediated by MAP kinases | R-HSA-450282 | 6.301421e-01 | 0.201 | 0 | 0 |
| The phototransduction cascade | R-HSA-2514856 | 6.388232e-01 | 0.195 | 0 | 0 |
| Regulation by c-FLIP | R-HSA-3371378 | 6.397309e-01 | 0.194 | 0 | 0 |
| Dimerization of procaspase-8 | R-HSA-69416 | 6.397309e-01 | 0.194 | 0 | 0 |
| EGFR interacts with phospholipase C-gamma | R-HSA-212718 | 6.397309e-01 | 0.194 | 0 | 0 |
| SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | R-HSA-77588 | 6.397309e-01 | 0.194 | 0 | 0 |
| phospho-PLA2 pathway | R-HSA-111995 | 6.397309e-01 | 0.194 | 0 | 0 |
| Signaling by MRAS-complex mutants | R-HSA-9660537 | 6.397309e-01 | 0.194 | 0 | 0 |
| Gain-of-function MRAS complexes activate RAF signaling | R-HSA-9726842 | 6.397309e-01 | 0.194 | 0 | 0 |
| Toxicity of botulinum toxin type B (botB) | R-HSA-5250958 | 6.397309e-01 | 0.194 | 0 | 0 |
| Interleukin-9 signaling | R-HSA-8985947 | 6.397309e-01 | 0.194 | 0 | 0 |
| BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | R-HSA-111453 | 6.397309e-01 | 0.194 | 0 | 0 |
| Axonal growth inhibition (RHOA activation) | R-HSA-193634 | 6.397309e-01 | 0.194 | 0 | 0 |
| TGFBR3 PTM regulation | R-HSA-9839383 | 6.397309e-01 | 0.194 | 0 | 0 |
| Neurotransmitter uptake and metabolism In glial cells | R-HSA-112313 | 6.397309e-01 | 0.194 | 0 | 0 |
| Astrocytic Glutamate-Glutamine Uptake And Metabolism | R-HSA-210455 | 6.397309e-01 | 0.194 | 0 | 0 |
| Sodium/Proton exchangers | R-HSA-425986 | 6.397309e-01 | 0.194 | 0 | 0 |
| Interleukin-23 signaling | R-HSA-9020933 | 6.397309e-01 | 0.194 | 0 | 0 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 6.406223e-01 | 0.193 | 0 | 0 |
| GABA synthesis, release, reuptake and degradation | R-HSA-888590 | 6.488395e-01 | 0.188 | 0 | 0 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | R-HSA-1474151 | 6.488395e-01 | 0.188 | 0 | 0 |
| Pre-NOTCH Processing in Golgi | R-HSA-1912420 | 6.521027e-01 | 0.186 | 0 | 0 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 6.521027e-01 | 0.186 | 0 | 0 |
| Germ layer formation at gastrulation | R-HSA-9754189 | 6.521027e-01 | 0.186 | 0 | 0 |
| Signaling by FGFR2 IIIa TM | R-HSA-8851708 | 6.521027e-01 | 0.186 | 0 | 0 |
| The NLRP3 inflammasome | R-HSA-844456 | 6.521027e-01 | 0.186 | 0 | 0 |
| Transcriptional Regulation by NPAS4 | R-HSA-9634815 | 6.532221e-01 | 0.185 | 0 | 0 |
| Ion transport by P-type ATPases | R-HSA-936837 | 6.570974e-01 | 0.182 | 0 | 0 |
| Toll-like Receptor Cascades | R-HSA-168898 | 6.635787e-01 | 0.178 | 0 | 0 |
| Telomere C-strand (Lagging Strand) Synthesis | R-HSA-174417 | 6.658150e-01 | 0.177 | 0 | 0 |
| Signaling by FGFR1 in disease | R-HSA-5655302 | 6.658150e-01 | 0.177 | 0 | 0 |
| Respiratory syncytial virus (RSV) attachment and entry | R-HSA-9820960 | 6.668535e-01 | 0.176 | 0 | 0 |
| Downstream signal transduction | R-HSA-186763 | 6.668535e-01 | 0.176 | 0 | 0 |
| Lipophagy | R-HSA-9613354 | 6.716739e-01 | 0.173 | 0 | 0 |
| WNT mediated activation of DVL | R-HSA-201688 | 6.716739e-01 | 0.173 | 0 | 0 |
| CASP8 activity is inhibited | R-HSA-5218900 | 6.716739e-01 | 0.173 | 0 | 0 |
| Toxicity of botulinum toxin type A (botA) | R-HSA-5250968 | 6.716739e-01 | 0.173 | 0 | 0 |
| p75NTR regulates axonogenesis | R-HSA-193697 | 6.716739e-01 | 0.173 | 0 | 0 |
| Caspase activation via Dependence Receptors in the absence of ligand | R-HSA-418889 | 6.716739e-01 | 0.173 | 0 | 0 |
| Interleukin-21 signaling | R-HSA-9020958 | 6.716739e-01 | 0.173 | 0 | 0 |
| Regulation of CDH11 gene transcription | R-HSA-9762293 | 6.716739e-01 | 0.173 | 0 | 0 |
| Activation of the TFAP2 (AP-2) family of transcription factors | R-HSA-8866907 | 6.716739e-01 | 0.173 | 0 | 0 |
| Interleukin-1 processing | R-HSA-448706 | 6.716739e-01 | 0.173 | 0 | 0 |
| Regulated proteolysis of p75NTR | R-HSA-193692 | 6.716739e-01 | 0.173 | 0 | 0 |
| Zinc influx into cells by the SLC39 gene family | R-HSA-442380 | 6.716739e-01 | 0.173 | 0 | 0 |
| Regulation of PD-L1(CD274) translation | R-HSA-9909620 | 6.738386e-01 | 0.171 | 0 | 0 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | R-HSA-9609523 | 6.738386e-01 | 0.171 | 0 | 0 |
| Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 6.738386e-01 | 0.171 | 0 | 0 |
| BBSome-mediated cargo-targeting to cilium | R-HSA-5620922 | 6.738386e-01 | 0.171 | 0 | 0 |
| Creatine metabolism | R-HSA-71288 | 6.738386e-01 | 0.171 | 0 | 0 |
| Formation of definitive endoderm | R-HSA-9823730 | 6.738386e-01 | 0.171 | 0 | 0 |
| G alpha (12/13) signalling events | R-HSA-416482 | 6.846908e-01 | 0.165 | 0 | 0 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 6.944570e-01 | 0.158 | 0 | 0 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 6.944570e-01 | 0.158 | 0 | 0 |
| Acetylcholine Neurotransmitter Release Cycle | R-HSA-264642 | 6.944570e-01 | 0.158 | 0 | 0 |
| Signalling to RAS | R-HSA-167044 | 6.944570e-01 | 0.158 | 0 | 0 |
| Basigin interactions | R-HSA-210991 | 6.944570e-01 | 0.158 | 0 | 0 |
| Signaling by SCF-KIT | R-HSA-1433557 | 6.956987e-01 | 0.158 | 0 | 0 |
| Signaling by FGFR4 | R-HSA-5654743 | 6.956987e-01 | 0.158 | 0 | 0 |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | R-HSA-2151209 | 7.007865e-01 | 0.154 | 0 | 0 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | R-HSA-5140745 | 7.007865e-01 | 0.154 | 0 | 0 |
| DNA replication initiation | R-HSA-68952 | 7.007865e-01 | 0.154 | 0 | 0 |
| Defective RIPK1-mediated regulated necrosis | R-HSA-9693928 | 7.007865e-01 | 0.154 | 0 | 0 |
| Formation of apoptosome | R-HSA-111458 | 7.007865e-01 | 0.154 | 0 | 0 |
| Regulation of the apoptosome activity | R-HSA-9627069 | 7.007865e-01 | 0.154 | 0 | 0 |
| Maturation of spike protein | R-HSA-9683686 | 7.007865e-01 | 0.154 | 0 | 0 |
| Regulation of Expression and Function of Type II Classical Cadherins | R-HSA-9764260 | 7.008303e-01 | 0.154 | 0 | 0 |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | R-HSA-9856530 | 7.069893e-01 | 0.151 | 0 | 0 |
| Signaling by MET | R-HSA-6806834 | 7.069893e-01 | 0.151 | 0 | 0 |
| Signaling by FGFR2 | R-HSA-5654738 | 7.069893e-01 | 0.151 | 0 | 0 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 7.139852e-01 | 0.146 | 0 | 0 |
| Attachment and Entry | R-HSA-9694614 | 7.139852e-01 | 0.146 | 0 | 0 |
| Serine metabolism | R-HSA-977347 | 7.139852e-01 | 0.146 | 0 | 0 |
| Regulation of CDH1 posttranslational processing and trafficking to plasma membrane | R-HSA-9768727 | 7.168004e-01 | 0.145 | 0 | 0 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 7.168004e-01 | 0.145 | 0 | 0 |
| Effects of PIP2 hydrolysis | R-HSA-114508 | 7.168004e-01 | 0.145 | 0 | 0 |
| Circadian clock | R-HSA-9909396 | 7.177514e-01 | 0.144 | 0 | 0 |
| Neddylation | R-HSA-8951664 | 7.215140e-01 | 0.142 | 0 | 0 |
| Signaling by FGFR3 | R-HSA-5654741 | 7.236194e-01 | 0.140 | 0 | 0 |
| Signaling by APC mutants | R-HSA-4839744 | 7.273192e-01 | 0.138 | 0 | 0 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 7.273192e-01 | 0.138 | 0 | 0 |
| Truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 7.273192e-01 | 0.138 | 0 | 0 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 7.273192e-01 | 0.138 | 0 | 0 |
| vRNA Synthesis | R-HSA-192814 | 7.273192e-01 | 0.138 | 0 | 0 |
| Chylomicron assembly | R-HSA-8963888 | 7.273192e-01 | 0.138 | 0 | 0 |
| RUNX2 regulates genes involved in cell migration | R-HSA-8941332 | 7.273192e-01 | 0.138 | 0 | 0 |
| Dissolution of Fibrin Clot | R-HSA-75205 | 7.273192e-01 | 0.138 | 0 | 0 |
| Developmental Lineage of Mammary Gland Alveolar Cells | R-HSA-9927426 | 7.321013e-01 | 0.135 | 0 | 0 |
| Signal amplification | R-HSA-392518 | 7.321013e-01 | 0.135 | 0 | 0 |
| Dopamine Neurotransmitter Release Cycle | R-HSA-212676 | 7.324543e-01 | 0.135 | 0 | 0 |
| LDL clearance | R-HSA-8964038 | 7.324543e-01 | 0.135 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy | R-HSA-9857377 | 7.324543e-01 | 0.135 | 0 | 0 |
| Transferrin endocytosis and recycling | R-HSA-917977 | 7.467429e-01 | 0.127 | 0 | 0 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 7.479384e-01 | 0.126 | 0 | 0 |
| Retrograde transport at the Trans-Golgi-Network | R-HSA-6811440 | 7.495899e-01 | 0.125 | 0 | 0 |
| Regulation of PTEN mRNA translation | R-HSA-8943723 | 7.498986e-01 | 0.125 | 0 | 0 |
| ABC transporters in lipid homeostasis | R-HSA-1369062 | 7.498986e-01 | 0.125 | 0 | 0 |
| Growth hormone receptor signaling | R-HSA-982772 | 7.498986e-01 | 0.125 | 0 | 0 |
| Synthesis of diphthamide-EEF2 | R-HSA-5358493 | 7.515006e-01 | 0.124 | 0 | 0 |
| Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | R-HSA-9931512 | 7.515006e-01 | 0.124 | 0 | 0 |
| Signaling by GSK3beta mutants | R-HSA-5339716 | 7.515006e-01 | 0.124 | 0 | 0 |
| Proton-coupled monocarboxylate transport | R-HSA-433692 | 7.515006e-01 | 0.124 | 0 | 0 |
| Plasmalogen biosynthesis | R-HSA-75896 | 7.515006e-01 | 0.124 | 0 | 0 |
| Signaling by AMER1 mutants | R-HSA-4839748 | 7.515006e-01 | 0.124 | 0 | 0 |
| Signaling by AXIN mutants | R-HSA-4839735 | 7.515006e-01 | 0.124 | 0 | 0 |
| Sema4D mediated inhibition of cell attachment and migration | R-HSA-416550 | 7.515006e-01 | 0.124 | 0 | 0 |
| Viral RNP Complexes in the Host Cell Nucleus | R-HSA-168330 | 7.515006e-01 | 0.124 | 0 | 0 |
| Sodium/Calcium exchangers | R-HSA-425561 | 7.515006e-01 | 0.124 | 0 | 0 |
| Metabolism of polyamines | R-HSA-351202 | 7.547525e-01 | 0.122 | 0 | 0 |
| Disease | R-HSA-1643685 | 7.559181e-01 | 0.122 | 0 | 0 |
| GPVI-mediated activation cascade | R-HSA-114604 | 7.607374e-01 | 0.119 | 0 | 0 |
| Co-stimulation by CD28 | R-HSA-389356 | 7.618544e-01 | 0.118 | 0 | 0 |
| Gluconeogenesis | R-HSA-70263 | 7.618544e-01 | 0.118 | 0 | 0 |
| Metal ion SLC transporters | R-HSA-425410 | 7.618544e-01 | 0.118 | 0 | 0 |
| Complex III assembly | R-HSA-9865881 | 7.663546e-01 | 0.116 | 0 | 0 |
| Norepinephrine Neurotransmitter Release Cycle | R-HSA-181430 | 7.663546e-01 | 0.116 | 0 | 0 |
| Mitochondrial RNA degradation | R-HSA-9836573 | 7.663546e-01 | 0.116 | 0 | 0 |
| Plasma lipoprotein assembly | R-HSA-8963898 | 7.663546e-01 | 0.116 | 0 | 0 |
| Interleukin-6 family signaling | R-HSA-6783589 | 7.663546e-01 | 0.116 | 0 | 0 |
| Signaling by FGFR in disease | R-HSA-1226099 | 7.708421e-01 | 0.113 | 0 | 0 |
| Mitochondrial biogenesis | R-HSA-1592230 | 7.718753e-01 | 0.112 | 0 | 0 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | R-HSA-9027276 | 7.735388e-01 | 0.112 | 0 | 0 |
| Signaling by CTNNB1 phospho-site mutants | R-HSA-4839743 | 7.735388e-01 | 0.112 | 0 | 0 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | R-HSA-3656253 | 7.735388e-01 | 0.112 | 0 | 0 |
| Defective EXT2 causes exostoses 2 | R-HSA-3656237 | 7.735388e-01 | 0.112 | 0 | 0 |
| CTNNB1 T41 mutants aren't phosphorylated | R-HSA-5358752 | 7.735388e-01 | 0.112 | 0 | 0 |
| CTNNB1 S33 mutants aren't phosphorylated | R-HSA-5358747 | 7.735388e-01 | 0.112 | 0 | 0 |
| CTNNB1 S37 mutants aren't phosphorylated | R-HSA-5358749 | 7.735388e-01 | 0.112 | 0 | 0 |
| CTNNB1 S45 mutants aren't phosphorylated | R-HSA-5358751 | 7.735388e-01 | 0.112 | 0 | 0 |
| Beta oxidation of myristoyl-CoA to lauroyl-CoA | R-HSA-77285 | 7.735388e-01 | 0.112 | 0 | 0 |
| Beta oxidation of palmitoyl-CoA to myristoyl-CoA | R-HSA-77305 | 7.735388e-01 | 0.112 | 0 | 0 |
| RUNX3 regulates NOTCH signaling | R-HSA-8941856 | 7.735388e-01 | 0.112 | 0 | 0 |
| GRB2 events in EGFR signaling | R-HSA-179812 | 7.735388e-01 | 0.112 | 0 | 0 |
| Advanced glycosylation endproduct receptor signaling | R-HSA-879415 | 7.735388e-01 | 0.112 | 0 | 0 |
| Erythrocytes take up oxygen and release carbon dioxide | R-HSA-1247673 | 7.735388e-01 | 0.112 | 0 | 0 |
| OAS antiviral response | R-HSA-8983711 | 7.735388e-01 | 0.112 | 0 | 0 |
| Signaling by PDGF | R-HSA-186797 | 7.763147e-01 | 0.110 | 0 | 0 |
| Interleukin-7 signaling | R-HSA-1266695 | 7.818603e-01 | 0.107 | 0 | 0 |
| Developmental Cell Lineages of the Exocrine Pancreas | R-HSA-9820448 | 7.927838e-01 | 0.101 | 0 | 0 |
| Frs2-mediated activation | R-HSA-170968 | 7.936238e-01 | 0.100 | 0 | 0 |
| Platelet Adhesion to exposed collagen | R-HSA-75892 | 7.936238e-01 | 0.100 | 0 | 0 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 7.936238e-01 | 0.100 | 0 | 0 |
| Replication of the SARS-CoV-1 genome | R-HSA-9682706 | 7.936238e-01 | 0.100 | 0 | 0 |
| Caspase activation via extrinsic apoptotic signalling pathway | R-HSA-5357769 | 7.964548e-01 | 0.099 | 0 | 0 |
| Glutamate Neurotransmitter Release Cycle | R-HSA-210500 | 7.964548e-01 | 0.099 | 0 | 0 |
| FOXO-mediated transcription | R-HSA-9614085 | 7.986560e-01 | 0.098 | 0 | 0 |
| Integrin cell surface interactions | R-HSA-216083 | 8.075582e-01 | 0.093 | 0 | 0 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 8.101777e-01 | 0.091 | 0 | 0 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 8.101777e-01 | 0.091 | 0 | 0 |
| CD28 dependent PI3K/Akt signaling | R-HSA-389357 | 8.101777e-01 | 0.091 | 0 | 0 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | R-HSA-6803204 | 8.101777e-01 | 0.091 | 0 | 0 |
| Asparagine N-linked glycosylation | R-HSA-446203 | 8.108353e-01 | 0.091 | 0 | 0 |
| Retrograde neurotrophin signalling | R-HSA-177504 | 8.119286e-01 | 0.090 | 0 | 0 |
| ERBB2 Activates PTK6 Signaling | R-HSA-8847993 | 8.119286e-01 | 0.090 | 0 | 0 |
| CLEC7A (Dectin-1) induces NFAT activation | R-HSA-5607763 | 8.119286e-01 | 0.090 | 0 | 0 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | R-HSA-2032785 | 8.119286e-01 | 0.090 | 0 | 0 |
| Hydrolysis of LPC | R-HSA-1483115 | 8.119286e-01 | 0.090 | 0 | 0 |
| Physiological factors | R-HSA-5578768 | 8.119286e-01 | 0.090 | 0 | 0 |
| Respiratory syncytial virus genome transcription | R-HSA-9828642 | 8.119286e-01 | 0.090 | 0 | 0 |
| HDL assembly | R-HSA-8963896 | 8.119286e-01 | 0.090 | 0 | 0 |
| Zinc transporters | R-HSA-435354 | 8.119286e-01 | 0.090 | 0 | 0 |
| SARS-CoV-1 Genome Replication and Transcription | R-HSA-9679514 | 8.119286e-01 | 0.090 | 0 | 0 |
| Extra-nuclear estrogen signaling | R-HSA-9009391 | 8.139077e-01 | 0.089 | 0 | 0 |
| Telomere Extension By Telomerase | R-HSA-171319 | 8.230688e-01 | 0.085 | 0 | 0 |
| Inflammasomes | R-HSA-622312 | 8.230688e-01 | 0.085 | 0 | 0 |
| Erythropoietin activates RAS | R-HSA-9027284 | 8.286107e-01 | 0.082 | 0 | 0 |
| SHC1 events in EGFR signaling | R-HSA-180336 | 8.286107e-01 | 0.082 | 0 | 0 |
| Protein lipoylation | R-HSA-9857492 | 8.286107e-01 | 0.082 | 0 | 0 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 8.286107e-01 | 0.082 | 0 | 0 |
| G beta:gamma signalling through BTK | R-HSA-8964315 | 8.286107e-01 | 0.082 | 0 | 0 |
| Beta oxidation of butanoyl-CoA to acetyl-CoA | R-HSA-77352 | 8.286107e-01 | 0.082 | 0 | 0 |
| Other semaphorin interactions | R-HSA-416700 | 8.286107e-01 | 0.082 | 0 | 0 |
| Signaling by PDGFRA extracellular domain mutants | R-HSA-9673770 | 8.286107e-01 | 0.082 | 0 | 0 |
| Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | R-HSA-9673767 | 8.286107e-01 | 0.082 | 0 | 0 |
| Signaling by Erythropoietin | R-HSA-9006335 | 8.351676e-01 | 0.078 | 0 | 0 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 8.351676e-01 | 0.078 | 0 | 0 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | R-HSA-983695 | 8.401476e-01 | 0.076 | 0 | 0 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 8.418783e-01 | 0.075 | 0 | 0 |
| Signaling by FGFR1 | R-HSA-5654736 | 8.436945e-01 | 0.074 | 0 | 0 |
| Caspase activation via Death Receptors in the presence of ligand | R-HSA-140534 | 8.438141e-01 | 0.074 | 0 | 0 |
| Entry of Influenza Virion into Host Cell via Endocytosis | R-HSA-168275 | 8.438141e-01 | 0.074 | 0 | 0 |
| WNT5:FZD7-mediated leishmania damping | R-HSA-9673324 | 8.438141e-01 | 0.074 | 0 | 0 |
| Killing mechanisms | R-HSA-9664420 | 8.438141e-01 | 0.074 | 0 | 0 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | R-HSA-210744 | 8.438141e-01 | 0.074 | 0 | 0 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | R-HSA-9634600 | 8.438141e-01 | 0.074 | 0 | 0 |
| Differentiation of T cells | R-HSA-9945266 | 8.438141e-01 | 0.074 | 0 | 0 |
| Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | R-HSA-9942503 | 8.438141e-01 | 0.074 | 0 | 0 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | R-HSA-399955 | 8.438141e-01 | 0.074 | 0 | 0 |
| Attachment and Entry | R-HSA-9678110 | 8.438141e-01 | 0.074 | 0 | 0 |
| DAP12 signaling | R-HSA-2424491 | 8.465132e-01 | 0.072 | 0 | 0 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 8.465132e-01 | 0.072 | 0 | 0 |
| Interleukin-37 signaling | R-HSA-9008059 | 8.465132e-01 | 0.072 | 0 | 0 |
| COPII-mediated vesicle transport | R-HSA-204005 | 8.481703e-01 | 0.072 | 0 | 0 |
| Neuronal System | R-HSA-112316 | 8.504246e-01 | 0.070 | 0 | 0 |
| TBC/RABGAPs | R-HSA-8854214 | 8.512788e-01 | 0.070 | 0 | 0 |
| Signaling by NTRK1 (TRKA) | R-HSA-187037 | 8.522765e-01 | 0.069 | 0 | 0 |
| Rab regulation of trafficking | R-HSA-9007101 | 8.558528e-01 | 0.068 | 0 | 0 |
| Cargo concentration in the ER | R-HSA-5694530 | 8.571440e-01 | 0.067 | 0 | 0 |
| Glycine degradation | R-HSA-6783984 | 8.576696e-01 | 0.067 | 0 | 0 |
| Defective B4GALT7 causes EDS, progeroid type | R-HSA-3560783 | 8.576696e-01 | 0.067 | 0 | 0 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | R-HSA-4420332 | 8.576696e-01 | 0.067 | 0 | 0 |
| The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex | R-HSA-9931521 | 8.576696e-01 | 0.067 | 0 | 0 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 8.576696e-01 | 0.067 | 0 | 0 |
| GRB2 events in ERBB2 signaling | R-HSA-1963640 | 8.576696e-01 | 0.067 | 0 | 0 |
| mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | R-HSA-77288 | 8.576696e-01 | 0.067 | 0 | 0 |
| mRNA decay by 5' to 3' exoribonuclease | R-HSA-430039 | 8.576696e-01 | 0.067 | 0 | 0 |
| Acetylcholine regulates insulin secretion | R-HSA-399997 | 8.576696e-01 | 0.067 | 0 | 0 |
| Synthesis of PG | R-HSA-1483148 | 8.576696e-01 | 0.067 | 0 | 0 |
| Coenzyme A biosynthesis | R-HSA-196783 | 8.576696e-01 | 0.067 | 0 | 0 |
| Early SARS-CoV-2 Infection Events | R-HSA-9772572 | 8.600042e-01 | 0.065 | 0 | 0 |
| Extracellular matrix organization | R-HSA-1474244 | 8.600757e-01 | 0.065 | 0 | 0 |
| Parasite infection | R-HSA-9664407 | 8.601246e-01 | 0.065 | 0 | 0 |
| FCGR3A-mediated phagocytosis | R-HSA-9664422 | 8.601246e-01 | 0.065 | 0 | 0 |
| Leishmania phagocytosis | R-HSA-9664417 | 8.601246e-01 | 0.065 | 0 | 0 |
| Selenoamino acid metabolism | R-HSA-2408522 | 8.605581e-01 | 0.065 | 0 | 0 |
| Ion channel transport | R-HSA-983712 | 8.665782e-01 | 0.062 | 0 | 0 |
| RAB GEFs exchange GTP for GDP on RABs | R-HSA-8876198 | 8.670400e-01 | 0.062 | 0 | 0 |
| Defective B3GAT3 causes JDSSDHD | R-HSA-3560801 | 8.702967e-01 | 0.060 | 0 | 0 |
| PI3K events in ERBB2 signaling | R-HSA-1963642 | 8.702967e-01 | 0.060 | 0 | 0 |
| Choline catabolism | R-HSA-6798163 | 8.702967e-01 | 0.060 | 0 | 0 |
| Uptake and function of anthrax toxins | R-HSA-5210891 | 8.702967e-01 | 0.060 | 0 | 0 |
| Replication of the SARS-CoV-2 genome | R-HSA-9694686 | 8.702967e-01 | 0.060 | 0 | 0 |
| Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | R-HSA-163841 | 8.732736e-01 | 0.059 | 0 | 0 |
| Sphingolipid de novo biosynthesis | R-HSA-1660661 | 8.748376e-01 | 0.058 | 0 | 0 |
| Purinergic signaling in leishmaniasis infection | R-HSA-9660826 | 8.766104e-01 | 0.057 | 0 | 0 |
| Cell recruitment (pro-inflammatory response) | R-HSA-9664424 | 8.766104e-01 | 0.057 | 0 | 0 |
| Signaling by FGFR | R-HSA-190236 | 8.776510e-01 | 0.057 | 0 | 0 |
| Interleukin-4 and Interleukin-13 signaling | R-HSA-6785807 | 8.792532e-01 | 0.056 | 0 | 0 |
| G beta:gamma signalling through PLC beta | R-HSA-418217 | 8.818043e-01 | 0.055 | 0 | 0 |
| Presynaptic function of Kainate receptors | R-HSA-500657 | 8.818043e-01 | 0.055 | 0 | 0 |
| PKA activation in glucagon signalling | R-HSA-164378 | 8.818043e-01 | 0.055 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9679504 | 8.818043e-01 | 0.055 | 0 | 0 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 8.851173e-01 | 0.053 | 0 | 0 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 8.851173e-01 | 0.053 | 0 | 0 |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | R-HSA-9818027 | 8.851173e-01 | 0.053 | 0 | 0 |
| Heme degradation | R-HSA-189483 | 8.851173e-01 | 0.053 | 0 | 0 |
| Heme signaling | R-HSA-9707616 | 8.882921e-01 | 0.051 | 0 | 0 |
| Prostacyclin signalling through prostacyclin receptor | R-HSA-392851 | 8.922915e-01 | 0.049 | 0 | 0 |
| O2/CO2 exchange in erythrocytes | R-HSA-1480926 | 8.922915e-01 | 0.049 | 0 | 0 |
| Specification of the neural plate border | R-HSA-9834899 | 8.922915e-01 | 0.049 | 0 | 0 |
| Erythrocytes take up carbon dioxide and release oxygen | R-HSA-1237044 | 8.922915e-01 | 0.049 | 0 | 0 |
| SARS-CoV-2 Genome Replication and Transcription | R-HSA-9694682 | 8.922915e-01 | 0.049 | 0 | 0 |
| Regulation of TLR by endogenous ligand | R-HSA-5686938 | 8.932530e-01 | 0.049 | 0 | 0 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 9.008501e-01 | 0.045 | 0 | 0 |
| VxPx cargo-targeting to cilium | R-HSA-5620916 | 9.018488e-01 | 0.045 | 0 | 0 |
| Wax and plasmalogen biosynthesis | R-HSA-8848584 | 9.018488e-01 | 0.045 | 0 | 0 |
| Acyl chain remodelling of PI | R-HSA-1482922 | 9.018488e-01 | 0.045 | 0 | 0 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 9.079401e-01 | 0.042 | 0 | 0 |
| FGFR2 mutant receptor activation | R-HSA-1839126 | 9.079401e-01 | 0.042 | 0 | 0 |
| G-protein activation | R-HSA-202040 | 9.105585e-01 | 0.041 | 0 | 0 |
| ADP signalling through P2Y purinoceptor 12 | R-HSA-392170 | 9.105585e-01 | 0.041 | 0 | 0 |
| ERK/MAPK targets | R-HSA-198753 | 9.105585e-01 | 0.041 | 0 | 0 |
| Regulation of MITF-M-dependent genes involved in apoptosis | R-HSA-9824594 | 9.105585e-01 | 0.041 | 0 | 0 |
| Zygotic genome activation (ZGA) | R-HSA-9819196 | 9.105585e-01 | 0.041 | 0 | 0 |
| Vitamin C (ascorbate) metabolism | R-HSA-196836 | 9.105585e-01 | 0.041 | 0 | 0 |
| Acyl chain remodelling of PG | R-HSA-1482925 | 9.105585e-01 | 0.041 | 0 | 0 |
| Transcriptional activation of mitochondrial biogenesis | R-HSA-2151201 | 9.147688e-01 | 0.039 | 0 | 0 |
| Kidney development | R-HSA-9830369 | 9.165287e-01 | 0.038 | 0 | 0 |
| Mitochondrial calcium ion transport | R-HSA-8949215 | 9.184959e-01 | 0.037 | 0 | 0 |
| Metabolism of Angiotensinogen to Angiotensins | R-HSA-2022377 | 9.184959e-01 | 0.037 | 0 | 0 |
| Ribavirin ADME | R-HSA-9755088 | 9.184959e-01 | 0.037 | 0 | 0 |
| Mitochondrial protein degradation | R-HSA-9837999 | 9.190841e-01 | 0.037 | 0 | 0 |
| Platelet homeostasis | R-HSA-418346 | 9.199773e-01 | 0.036 | 0 | 0 |
| MET promotes cell motility | R-HSA-8875878 | 9.207181e-01 | 0.036 | 0 | 0 |
| PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 9.215775e-01 | 0.035 | 0 | 0 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | R-HSA-9694676 | 9.257292e-01 | 0.034 | 0 | 0 |
| Expression of BMAL (ARNTL), CLOCK, and NPAS2 | R-HSA-9931509 | 9.264623e-01 | 0.033 | 0 | 0 |
| Cardiac conduction | R-HSA-5576891 | 9.269624e-01 | 0.033 | 0 | 0 |
| Stimuli-sensing channels | R-HSA-2672351 | 9.274413e-01 | 0.033 | 0 | 0 |
| Degradation of the extracellular matrix | R-HSA-1474228 | 9.301741e-01 | 0.031 | 0 | 0 |
| Interleukin-20 family signaling | R-HSA-8854691 | 9.323211e-01 | 0.030 | 0 | 0 |
| Formation of the ureteric bud | R-HSA-9830674 | 9.323211e-01 | 0.030 | 0 | 0 |
| Mitochondrial mRNA modification | R-HSA-9937008 | 9.323211e-01 | 0.030 | 0 | 0 |
| The role of Nef in HIV-1 replication and disease pathogenesis | R-HSA-164952 | 9.323211e-01 | 0.030 | 0 | 0 |
| Detoxification of Reactive Oxygen Species | R-HSA-3299685 | 9.355605e-01 | 0.029 | 0 | 0 |
| Maturation of spike protein | R-HSA-9694548 | 9.367915e-01 | 0.028 | 0 | 0 |
| Translocation of ZAP-70 to Immunological synapse | R-HSA-202430 | 9.383282e-01 | 0.028 | 0 | 0 |
| Thromboxane signalling through TP receptor | R-HSA-428930 | 9.383282e-01 | 0.028 | 0 | 0 |
| Intra-Golgi traffic | R-HSA-6811438 | 9.414249e-01 | 0.026 | 0 | 0 |
| Scavenging by Class A Receptors | R-HSA-3000480 | 9.414249e-01 | 0.026 | 0 | 0 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | R-HSA-9615017 | 9.414249e-01 | 0.026 | 0 | 0 |
| Diseases of carbohydrate metabolism | R-HSA-5663084 | 9.418728e-01 | 0.026 | 0 | 0 |
| Signaling by NTRKs | R-HSA-166520 | 9.430518e-01 | 0.025 | 0 | 0 |
| G protein gated Potassium channels | R-HSA-1296059 | 9.438024e-01 | 0.025 | 0 | 0 |
| Activation of G protein gated Potassium channels | R-HSA-1296041 | 9.438024e-01 | 0.025 | 0 | 0 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | R-HSA-997272 | 9.438024e-01 | 0.025 | 0 | 0 |
| Tight junction interactions | R-HSA-420029 | 9.438024e-01 | 0.025 | 0 | 0 |
| Glycogen breakdown (glycogenolysis) | R-HSA-70221 | 9.438024e-01 | 0.025 | 0 | 0 |
| Hyaluronan degradation | R-HSA-2160916 | 9.438024e-01 | 0.025 | 0 | 0 |
| MicroRNA (miRNA) biogenesis | R-HSA-203927 | 9.438024e-01 | 0.025 | 0 | 0 |
| PIWI-interacting RNA (piRNA) biogenesis | R-HSA-5601884 | 9.438024e-01 | 0.025 | 0 | 0 |
| Cytosolic tRNA aminoacylation | R-HSA-379716 | 9.457340e-01 | 0.024 | 0 | 0 |
| Regulation of beta-cell development | R-HSA-186712 | 9.473457e-01 | 0.023 | 0 | 0 |
| Amino acid transport across the plasma membrane | R-HSA-352230 | 9.473457e-01 | 0.023 | 0 | 0 |
| MET activates PTK2 signaling | R-HSA-8874081 | 9.487911e-01 | 0.023 | 0 | 0 |
| Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes | R-HSA-9931510 | 9.487911e-01 | 0.023 | 0 | 0 |
| Adrenaline,noradrenaline inhibits insulin secretion | R-HSA-400042 | 9.487911e-01 | 0.023 | 0 | 0 |
| TRP channels | R-HSA-3295583 | 9.487911e-01 | 0.023 | 0 | 0 |
| Urea cycle | R-HSA-70635 | 9.487911e-01 | 0.023 | 0 | 0 |
| Sphingolipid catabolism | R-HSA-9845614 | 9.487911e-01 | 0.023 | 0 | 0 |
| Abacavir ADME | R-HSA-2161522 | 9.487911e-01 | 0.023 | 0 | 0 |
| Synthesis of PIPs at the Golgi membrane | R-HSA-1660514 | 9.487911e-01 | 0.023 | 0 | 0 |
| Regulation of RUNX1 Expression and Activity | R-HSA-8934593 | 9.487911e-01 | 0.023 | 0 | 0 |
| Leishmania infection | R-HSA-9658195 | 9.523822e-01 | 0.021 | 0 | 0 |
| Parasitic Infection Pathways | R-HSA-9824443 | 9.523822e-01 | 0.021 | 0 | 0 |
| Triglyceride biosynthesis | R-HSA-75109 | 9.533372e-01 | 0.021 | 0 | 0 |
| Maturation of hRSV A proteins | R-HSA-9828806 | 9.533372e-01 | 0.021 | 0 | 0 |
| DAP12 interactions | R-HSA-2172127 | 9.534629e-01 | 0.021 | 0 | 0 |
| SLC transporter disorders | R-HSA-5619102 | 9.554038e-01 | 0.020 | 0 | 0 |
| ADORA2B mediated anti-inflammatory cytokines production | R-HSA-9660821 | 9.569211e-01 | 0.019 | 0 | 0 |
| mitochondrial fatty acid beta-oxidation of saturated fatty acids | R-HSA-77286 | 9.569211e-01 | 0.019 | 0 | 0 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 9.569211e-01 | 0.019 | 0 | 0 |
| NCAM signaling for neurite out-growth | R-HSA-375165 | 9.570985e-01 | 0.019 | 0 | 0 |
| RUNX2 regulates osteoblast differentiation | R-HSA-8940973 | 9.574799e-01 | 0.019 | 0 | 0 |
| Prednisone ADME | R-HSA-9757110 | 9.574799e-01 | 0.019 | 0 | 0 |
| Activation of gene expression by SREBF (SREBP) | R-HSA-2426168 | 9.599542e-01 | 0.018 | 0 | 0 |
| Glucagon-type ligand receptors | R-HSA-420092 | 9.612551e-01 | 0.017 | 0 | 0 |
| Adipogenesis | R-HSA-9843745 | 9.621206e-01 | 0.017 | 0 | 0 |
| tRNA processing | R-HSA-72306 | 9.627133e-01 | 0.017 | 0 | 0 |
| Synthesis of PC | R-HSA-1483191 | 9.631133e-01 | 0.016 | 0 | 0 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 9.646953e-01 | 0.016 | 0 | 0 |
| RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | R-HSA-9933387 | 9.646953e-01 | 0.016 | 0 | 0 |
| GPER1 signaling | R-HSA-9634597 | 9.658794e-01 | 0.015 | 0 | 0 |
| Infection with Mycobacterium tuberculosis | R-HSA-9635486 | 9.664553e-01 | 0.015 | 0 | 0 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 9.684454e-01 | 0.014 | 0 | 0 |
| SLC-mediated transport of amino acids | R-HSA-9958863 | 9.696844e-01 | 0.013 | 0 | 0 |
| Signaling by WNT in cancer | R-HSA-4791275 | 9.706869e-01 | 0.013 | 0 | 0 |
| Inwardly rectifying K+ channels | R-HSA-1296065 | 9.706869e-01 | 0.013 | 0 | 0 |
| HS-GAG degradation | R-HSA-2024096 | 9.706869e-01 | 0.013 | 0 | 0 |
| Signaling by FGFR2 in disease | R-HSA-5655253 | 9.708248e-01 | 0.013 | 0 | 0 |
| Regulation of insulin secretion | R-HSA-422356 | 9.731749e-01 | 0.012 | 0 | 0 |
| Cardiogenesis | R-HSA-9733709 | 9.732901e-01 | 0.012 | 0 | 0 |
| Recycling of bile acids and salts | R-HSA-159418 | 9.732901e-01 | 0.012 | 0 | 0 |
| Vitamin B5 (pantothenate) metabolism | R-HSA-199220 | 9.756622e-01 | 0.011 | 0 | 0 |
| Amino acids regulate mTORC1 | R-HSA-9639288 | 9.769693e-01 | 0.010 | 0 | 0 |
| Metabolism of cofactors | R-HSA-8978934 | 9.771476e-01 | 0.010 | 0 | 0 |
| Glycosaminoglycan-protein linkage region biosynthesis | R-HSA-1971475 | 9.778239e-01 | 0.010 | 0 | 0 |
| Hyaluronan metabolism | R-HSA-2142845 | 9.778239e-01 | 0.010 | 0 | 0 |
| BMAL1:CLOCK,NPAS2 activates circadian expression | R-HSA-1368108 | 9.778239e-01 | 0.010 | 0 | 0 |
| Interconversion of nucleotide di- and triphosphates | R-HSA-499943 | 9.787197e-01 | 0.009 | 0 | 0 |
| Aspirin ADME | R-HSA-9749641 | 9.801883e-01 | 0.009 | 0 | 0 |
| Paracetamol ADME | R-HSA-9753281 | 9.803484e-01 | 0.009 | 0 | 0 |
| ROS and RNS production in phagocytes | R-HSA-1222556 | 9.815599e-01 | 0.008 | 0 | 0 |
| HS-GAG biosynthesis | R-HSA-2022928 | 9.815885e-01 | 0.008 | 0 | 0 |
| RUNX2 regulates bone development | R-HSA-8941326 | 9.815885e-01 | 0.008 | 0 | 0 |
| Triglyceride catabolism | R-HSA-163560 | 9.815885e-01 | 0.008 | 0 | 0 |
| NCAM1 interactions | R-HSA-419037 | 9.832240e-01 | 0.007 | 0 | 0 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 9.832240e-01 | 0.007 | 0 | 0 |
| Lysine catabolism | R-HSA-71064 | 9.832240e-01 | 0.007 | 0 | 0 |
| Collagen chain trimerization | R-HSA-8948216 | 9.832240e-01 | 0.007 | 0 | 0 |
| Metabolism of folate and pterines | R-HSA-196757 | 9.832240e-01 | 0.007 | 0 | 0 |
| Dectin-2 family | R-HSA-5621480 | 9.832444e-01 | 0.007 | 0 | 0 |
| Synthesis of PA | R-HSA-1483166 | 9.832444e-01 | 0.007 | 0 | 0 |
| Triglyceride metabolism | R-HSA-8979227 | 9.857239e-01 | 0.006 | 0 | 0 |
| Assembly of collagen fibrils and other multimeric structures | R-HSA-2022090 | 9.857239e-01 | 0.006 | 0 | 0 |
| Pentose phosphate pathway | R-HSA-71336 | 9.860724e-01 | 0.006 | 0 | 0 |
| RAB geranylgeranylation | R-HSA-8873719 | 9.868259e-01 | 0.006 | 0 | 0 |
| tRNA Aminoacylation | R-HSA-379724 | 9.868259e-01 | 0.006 | 0 | 0 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | R-HSA-1655829 | 9.871614e-01 | 0.006 | 0 | 0 |
| Interleukin-2 family signaling | R-HSA-451927 | 9.873099e-01 | 0.006 | 0 | 0 |
| Mitochondrial tRNA aminoacylation | R-HSA-379726 | 9.873099e-01 | 0.006 | 0 | 0 |
| Mitochondrial Fatty Acid Beta-Oxidation | R-HSA-77289 | 9.877205e-01 | 0.005 | 0 | 0 |
| Aquaporin-mediated transport | R-HSA-445717 | 9.878448e-01 | 0.005 | 0 | 0 |
| Collagen degradation | R-HSA-1442490 | 9.878448e-01 | 0.005 | 0 | 0 |
| Purine ribonucleoside monophosphate biosynthesis | R-HSA-73817 | 9.884374e-01 | 0.005 | 0 | 0 |
| Mitochondrial protein import | R-HSA-1268020 | 9.887868e-01 | 0.005 | 0 | 0 |
| Synthesis of PIPs at the plasma membrane | R-HSA-1660499 | 9.887868e-01 | 0.005 | 0 | 0 |
| Activation of GABAB receptors | R-HSA-991365 | 9.904011e-01 | 0.004 | 0 | 0 |
| GABA B receptor activation | R-HSA-977444 | 9.904011e-01 | 0.004 | 0 | 0 |
| Cytoprotection by HMOX1 | R-HSA-9707564 | 9.904262e-01 | 0.004 | 0 | 0 |
| CD22 mediated BCR regulation | R-HSA-5690714 | 9.904619e-01 | 0.004 | 0 | 0 |
| Surfactant metabolism | R-HSA-5683826 | 9.920314e-01 | 0.003 | 0 | 0 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | R-HSA-2142691 | 9.920314e-01 | 0.003 | 0 | 0 |
| Negative regulation of the PI3K/AKT network | R-HSA-199418 | 9.922269e-01 | 0.003 | 0 | 0 |
| Diseases associated with glycosaminoglycan metabolism | R-HSA-3560782 | 9.927397e-01 | 0.003 | 0 | 0 |
| Collagen biosynthesis and modifying enzymes | R-HSA-1650814 | 9.931111e-01 | 0.003 | 0 | 0 |
| Innate Immune System | R-HSA-168249 | 9.932924e-01 | 0.003 | 0 | 0 |
| Peptide hormone metabolism | R-HSA-2980736 | 9.933339e-01 | 0.003 | 0 | 0 |
| Mitochondrial ribosome-associated quality control | R-HSA-9937383 | 9.933831e-01 | 0.003 | 0 | 0 |
| Fatty acyl-CoA biosynthesis | R-HSA-75105 | 9.941504e-01 | 0.003 | 0 | 0 |
| Plasma lipoprotein remodeling | R-HSA-8963899 | 9.945088e-01 | 0.002 | 0 | 0 |
| ECM proteoglycans | R-HSA-3000178 | 9.946108e-01 | 0.002 | 0 | 0 |
| Metabolism of porphyrins | R-HSA-189445 | 9.946108e-01 | 0.002 | 0 | 0 |
| Neurotransmitter release cycle | R-HSA-112310 | 9.947240e-01 | 0.002 | 0 | 0 |
| Glyoxylate metabolism and glycine degradation | R-HSA-389661 | 9.949970e-01 | 0.002 | 0 | 0 |
| Integration of energy metabolism | R-HSA-163685 | 9.952933e-01 | 0.002 | 0 | 0 |
| Azathioprine ADME | R-HSA-9748787 | 9.954418e-01 | 0.002 | 0 | 0 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | R-HSA-2162123 | 9.954418e-01 | 0.002 | 0 | 0 |
| Signaling by Insulin receptor | R-HSA-74752 | 9.957925e-01 | 0.002 | 0 | 0 |
| Complex IV assembly | R-HSA-9864848 | 9.958471e-01 | 0.002 | 0 | 0 |
| Cytosolic sulfonation of small molecules | R-HSA-156584 | 9.958471e-01 | 0.002 | 0 | 0 |
| TP53 Regulates Transcription of Cell Death Genes | R-HSA-5633008 | 9.961223e-01 | 0.002 | 0 | 0 |
| Bile acid and bile salt metabolism | R-HSA-194068 | 9.962301e-01 | 0.002 | 0 | 0 |
| Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 9.963845e-01 | 0.002 | 0 | 0 |
| Collagen formation | R-HSA-1474290 | 9.963845e-01 | 0.002 | 0 | 0 |
| Nucleotide biosynthesis | R-HSA-8956320 | 9.965528e-01 | 0.001 | 0 | 0 |
| FCGR3A-mediated IL10 synthesis | R-HSA-9664323 | 9.965737e-01 | 0.001 | 0 | 0 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 9.966466e-01 | 0.001 | 0 | 0 |
| FCERI mediated MAPK activation | R-HSA-2871796 | 9.967304e-01 | 0.001 | 0 | 0 |
| Leishmania parasite growth and survival | R-HSA-9664433 | 9.968729e-01 | 0.001 | 0 | 0 |
| Anti-inflammatory response favouring Leishmania parasite infection | R-HSA-9662851 | 9.968729e-01 | 0.001 | 0 | 0 |
| Interleukin-10 signaling | R-HSA-6783783 | 9.969744e-01 | 0.001 | 0 | 0 |
| Mitochondrial translation elongation | R-HSA-5389840 | 9.971235e-01 | 0.001 | 0 | 0 |
| Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 9.971235e-01 | 0.001 | 0 | 0 |
| Mitochondrial translation initiation | R-HSA-5368286 | 9.975320e-01 | 0.001 | 0 | 0 |
| Synthesis of bile acids and bile salts | R-HSA-192105 | 9.977144e-01 | 0.001 | 0 | 0 |
| FCERI mediated Ca+2 mobilization | R-HSA-2871809 | 9.977161e-01 | 0.001 | 0 | 0 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 9.977161e-01 | 0.001 | 0 | 0 |
| Visual phototransduction | R-HSA-2187338 | 9.978292e-01 | 0.001 | 0 | 0 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | R-HSA-9029569 | 9.978363e-01 | 0.001 | 0 | 0 |
| Heparan sulfate/heparin (HS-GAG) metabolism | R-HSA-1638091 | 9.980287e-01 | 0.001 | 0 | 0 |
| PI Metabolism | R-HSA-1483255 | 9.981862e-01 | 0.001 | 0 | 0 |
| GABA receptor activation | R-HSA-977443 | 9.982041e-01 | 0.001 | 0 | 0 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 9.983639e-01 | 0.001 | 0 | 0 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | R-HSA-6811558 | 9.987237e-01 | 0.001 | 0 | 0 |
| IGF1R signaling cascade | R-HSA-2428924 | 9.987629e-01 | 0.001 | 0 | 0 |
| Aerobic respiration and respiratory electron transport | R-HSA-1428517 | 9.988230e-01 | 0.001 | 0 | 0 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 9.988730e-01 | 0.000 | 0 | 0 |
| tRNA modification in the nucleus and cytosol | R-HSA-6782315 | 9.989733e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation termination | R-HSA-5419276 | 9.990265e-01 | 0.000 | 0 | 0 |
| Nicotinate metabolism | R-HSA-196807 | 9.990646e-01 | 0.000 | 0 | 0 |
| FCGR activation | R-HSA-2029481 | 9.992713e-01 | 0.000 | 0 | 0 |
| Glycosphingolipid catabolism | R-HSA-9840310 | 9.992928e-01 | 0.000 | 0 | 0 |
| Diseases associated with O-glycosylation of proteins | R-HSA-3906995 | 9.993558e-01 | 0.000 | 0 | 0 |
| Retinoid metabolism and transport | R-HSA-975634 | 9.993558e-01 | 0.000 | 0 | 0 |
| Citric acid cycle (TCA cycle) | R-HSA-71403 | 9.995563e-01 | 0.000 | 0 | 0 |
| NR1H2 and NR1H3-mediated signaling | R-HSA-9024446 | 9.996318e-01 | 0.000 | 0 | 0 |
| Nuclear Receptor transcription pathway | R-HSA-383280 | 9.996646e-01 | 0.000 | 0 | 0 |
| SLC-mediated transport of organic anions | R-HSA-9955298 | 9.996646e-01 | 0.000 | 0 | 0 |
| Mitochondrial translation | R-HSA-5368287 | 9.996660e-01 | 0.000 | 0 | 0 |
| Developmental Lineage of Pancreatic Acinar Cells | R-HSA-9925561 | 9.996945e-01 | 0.000 | 0 | 0 |
| Metabolism of fat-soluble vitamins | R-HSA-6806667 | 9.997465e-01 | 0.000 | 0 | 0 |
| Respiratory electron transport | R-HSA-611105 | 9.997518e-01 | 0.000 | 0 | 0 |
| Phospholipid metabolism | R-HSA-1483257 | 9.997568e-01 | 0.000 | 0 | 0 |
| Bacterial Infection Pathways | R-HSA-9824439 | 9.998027e-01 | 0.000 | 0 | 0 |
| Peroxisomal lipid metabolism | R-HSA-390918 | 9.998084e-01 | 0.000 | 0 | 0 |
| Peptide ligand-binding receptors | R-HSA-375276 | 9.998586e-01 | 0.000 | 0 | 0 |
| Binding and Uptake of Ligands by Scavenger Receptors | R-HSA-2173782 | 9.998760e-01 | 0.000 | 0 | 0 |
| Class B/2 (Secretin family receptors) | R-HSA-373080 | 9.999003e-01 | 0.000 | 0 | 0 |
| Metabolism of carbohydrates and carbohydrate derivatives | R-HSA-71387 | 9.999306e-01 | 0.000 | 0 | 0 |
| Sphingolipid metabolism | R-HSA-428157 | 9.999516e-01 | 0.000 | 0 | 0 |
| Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 9.999528e-01 | 0.000 | 0 | 0 |
| Potassium Channels | R-HSA-1296071 | 9.999528e-01 | 0.000 | 0 | 0 |
| Formation of the cornified envelope | R-HSA-6809371 | 9.999638e-01 | 0.000 | 0 | 0 |
| Arachidonate metabolism | R-HSA-2142753 | 9.999813e-01 | 0.000 | 0 | 0 |
| Antimicrobial peptides | R-HSA-6803157 | 9.999894e-01 | 0.000 | 0 | 0 |
| Transport of small molecules | R-HSA-382551 | 9.999916e-01 | 0.000 | 0 | 0 |
| G alpha (q) signalling events | R-HSA-416476 | 9.999926e-01 | 0.000 | 0 | 0 |
| Initial triggering of complement | R-HSA-166663 | 9.999927e-01 | 0.000 | 0 | 0 |
| G alpha (s) signalling events | R-HSA-418555 | 9.999965e-01 | 0.000 | 0 | 0 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 9.999969e-01 | 0.000 | 0 | 0 |
| Glycosphingolipid metabolism | R-HSA-1660662 | 9.999971e-01 | 0.000 | 0 | 0 |
| Drug ADME | R-HSA-9748784 | 9.999972e-01 | 0.000 | 0 | 0 |
| Regulation of Complement cascade | R-HSA-977606 | 9.999976e-01 | 0.000 | 0 | 0 |
| G alpha (i) signalling events | R-HSA-418594 | 9.999981e-01 | 0.000 | 0 | 0 |
| PPARA activates gene expression | R-HSA-1989781 | 9.999983e-01 | 0.000 | 0 | 0 |
| Regulation of lipid metabolism by PPARalpha | R-HSA-400206 | 9.999986e-01 | 0.000 | 0 | 0 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 9.999988e-01 | 0.000 | 0 | 0 |
| Complement cascade | R-HSA-166658 | 9.999997e-01 | 0.000 | 0 | 0 |
| Infection with Enterobacteria | R-HSA-9640148 | 9.999998e-01 | 0.000 | 0 | 0 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 9.999998e-01 | 0.000 | 0 | 0 |
| Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 9.999998e-01 | 0.000 | 0 | 0 |
| Diseases of glycosylation | R-HSA-3781865 | 9.999999e-01 | 0.000 | 0 | 0 |
| Metabolism of amino acids and derivatives | R-HSA-71291 | 9.999999e-01 | 0.000 | 0 | 0 |
| Metabolism of nucleotides | R-HSA-15869 | 9.999999e-01 | 0.000 | 0 | 0 |
| Glycosaminoglycan metabolism | R-HSA-1630316 | 9.999999e-01 | 0.000 | 0 | 0 |
| Metabolism of steroids | R-HSA-8957322 | 1.000000e+00 | 0.000 | 0 | 0 |
| Keratinization | R-HSA-6805567 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of vitamins and cofactors | R-HSA-196854 | 1.000000e+00 | 0.000 | 0 | 0 |
| Fatty acid metabolism | R-HSA-8978868 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase I - Functionalization of compounds | R-HSA-211945 | 1.000000e+00 | 0.000 | 0 | 0 |
| GPCR downstream signalling | R-HSA-388396 | 1.000000e+00 | 0.000 | 0 | 0 |
| Phase II - Conjugation of compounds | R-HSA-156580 | 1.000000e+00 | 0.000 | 0 | 0 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 1.000000e+00 | 0.000 | 0 | 0 |
| Signaling by GPCR | R-HSA-372790 | 1.000000e+00 | 0.000 | 0 | 0 |
| Diseases of metabolism | R-HSA-5668914 | 1.000000e+00 | 0.000 | 0 | 0 |
| Metabolism of lipids | R-HSA-556833 | 1.000000e+00 | -0.000 | 0 | 0 |
| Metabolism | R-HSA-1430728 | 1.000000e+00 | -0.000 | 0 | 0 |
| Sensory Perception | R-HSA-9709957 | 1.000000e+00 | -0.000 | 0 | 0 |
| GPCR ligand binding | R-HSA-500792 | 1.000000e+00 | -0.000 | 0 | 0 |
| Biological oxidations | R-HSA-211859 | 1.000000e+00 | -0.000 | 0 | 0 |
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
