RSK2

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

Log-Odds: S Sites / S Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
A0A2R8Y4L2	S95	Sugiyama	HNRNPA1L3 HNRNPA1P48	RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A5A3E0	S1068	Sugiyama	POTEF A26C1B	SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00116	S65	Sugiyama	AGPS AAG5	LLGRPREALSTNECKARRAAsAAtAAPtAtPAAQEsGtIPK
O00170	S43	Sugiyama	AIP XAP2	GELPDFQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELI
O14649	S393	SIGNOR\|EPSD\|PSP	KCNK3 TASK TASK1	sVsTGLHSLStFRGLMKRRssV___________________
O14974	S695	Sugiyama	PPP1R12A MBS MYPT1	DEEsEsQRKARSRQARQsRRstQGVtLtDLQEAEKtIGRSR
O14974	S910	Sugiyama	PPP1R12A MBS MYPT1	yETssTsAGDRyDsLLGRsGsysYLEERKPYSSRLEKDDST
O14980	S1055	Sugiyama	XPO1 CRM1	LEEREIALRQADEEKHKRQMsVPGIFNPHEIPEEMCD____
O15067	S215	Sugiyama	PFAS KIAA0361	LDSWDLDFYTKRFQELQRNPstVEAFDLAQsNsEHSRHWFF
O15234	T13	Sugiyama	CASC3 MLN51	________MADRRRQRAsQDtEDEESGASGsDsGGsPLRGG
O15460	S531	Sugiyama	P4HA2 UNQ290/PRO330	KWVSNKWFHERGQEFLRPCGstEVD________________
O43175	S12	Sugiyama	PHGDH PGDH3	_________MAFANLRKVLIsDsLDPCCRKILQDGGLQVVE
O43379	S49	Sugiyama	WDR62 C19orf14	RGQssPPPAPPICLRRRtRLstAsEETVQNRVsLEKVLGIT
O43379	T50	Sugiyama	WDR62 C19orf14	GQssPPPAPPICLRRRtRLstAsEETVQNRVsLEKVLGITA
O43707	S423	Sugiyama	ACTN4	NEIRRLERLDHLAEKFRQKAsIHEAWtDGKEAMLKHRDyEt
O60293	S42	Sugiyama	ZFC3H1 CCDC131 KIAA0546 PSRC2	LEDGEIsDDDNNSQIRSRsssSsSGGGLLPYPRRRPPHSAR
O60343	T749	Sugiyama	TBC1D4 AS160 KIAA0603	ENEIRQDTASESSDGEGRKRtSstCsNEsLsVGGTSVTPRR
O60814	S37	Sugiyama	H2BC12 H2BFT HIRIP1 HIST1H2BK	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
O60825	S466	SIGNOR	PFKFB2	RDKPTNNFPKNQTPVRMRRNsFtPLsssNtIRRPRNYsVGs
O60841	S107	Sugiyama	EIF5B IF2 KIAA0741	NEEEFtsKDKKKKGQKGKKQsFDDNDsEELEDKDsKSKKTA
O60841	S182	Sugiyama	EIF5B IF2 KIAA0741	DGsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKK
O60841	S183	Sugiyama	EIF5B IF2 KIAA0741	GsEEDEDNsKKIKERsRINssGEsGDEsDEFLQsRKGQKKN
O75369	S1442	Sugiyama	FLNB FLN1L FLN3 TABP TAP	SKVKIAGPGLGsGVRARVLQsFtVDSSKAGLAPLEVRVLGP
O75534	S584	Sugiyama	CSDE1 D1S155E KIAA0885 NRU UNR	YSLSKGKGNKVSAEKVNKtHsVNGItEEADPTIysGKVIRP
O75534	T589	Sugiyama	CSDE1 D1S155E KIAA0885 NRU UNR	GKGNKVSAEKVNKtHsVNGItEEADPTIysGKVIRPLRSVD
O75582	T700	GPS6	RPS6KA5 MSK1	GLRYNEWLQDGSQLSSNPLMtPDILGSSGAAVHTCVKAtFH
O95831	S116	Sugiyama	AIFM1 AIF PDCD8	NERIsGLGLtPEQKQKKAALsAsEGEEVPQDKAPSHVPFLL
P00338	S161	Sugiyama	LDHA PIG19	DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00558	S390	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	IIGGGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPG
P00558	S399	Sugiyama	PGK1 PGKA MIG10 OK/SW-cl.110	CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P01100	S362	GPS6\|ELM\|EPSD	FOS G0S7	VFTYPEADSFPSCAAAHRKGsSsNEPSSDSLSsPTLLAL__
P03372	S167	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	ESR1 ESR NR3A1	PAFYRPNsDNRRQGGRERLAsTNDKGSMAMESAKETRYCAV
P04075	S39	Sugiyama	ALDOA ALDA	IAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRRFy
P04075	S46	Sugiyama	ALDOA ALDA	PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04083	S182	Sugiyama	ANXA1 ANX1 LPC1	RDLAKDItsDtsGDFRNALLsLAKGDRsEDFGVNEDLADsD
P04406	S241	Sugiyama	GAPDH GAPD CDABP0047 OK/SW-cl.12	IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04632	T85	Sugiyama	CAPNS1 CAPN4 CAPNS	VIsAISEAAAQYNPEPPPPRtHysNIEANEsEEVRQFRRLF
P04792	S82	Sugiyama	HSPB1 HSP27 HSP28	AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05114	S21	SIGNOR\|iPTMNet\|EPSD	HMGN1 HMG14	MPKRKVssAEGAAKEEPKRRsARLsAKPPAKVEAKPKKAAA
P05114	S25	SIGNOR\|iPTMNet\|EPSD	HMGN1 HMG14	KVssAEGAAKEEPKRRsARLsAKPPAKVEAKPKKAAAKDKS
P05114	S7	SIGNOR\|iPTMNet\|EPSD	HMGN1 HMG14	______________MPKRKVssAEGAAKEEPKRRsARLsAK
P05198	S52	EPSD\|PSP	EIF2S1 EIF2A	AYVSLLEYNNIEGMILLsELsRRRIRSINKLIRIGRNECVV
P05204	S25	SIGNOR\|iPTMNet\|EPSD	HMGN2 HMG17	KAEGDAKGDKAKVKDEPQRRsARLsAKPAPPKPEPKPKKAP
P05204	S29	SIGNOR\|iPTMNet\|EPSD	HMGN2 HMG17	DAKGDKAKVKDEPQRRsARLsAKPAPPKPEPKPKKAPAKKG
P05386	S101	Sugiyama	RPLP1 RRP1	APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05387	S102	Sugiyama	RPLP2 D11S2243E RPP2	PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05783	S53	SIGNOR\|iPTMNet\|EPSD	KRT18 CYK18 PIG46	AsVyAGAGGsGsRIsVsRstsFRGGMGsGGLAtGIAGGLAG
P05783	S93	Sugiyama	KRT18 CYK18 PIG46	GMGGIQNEKETMQsLNDRLAsyLDRVRSLETENRRLESKIR
P05787	S330	Sugiyama	KRT8 CYK8	MNRNISRLQAEIEGLKGQRAsLEAAIADAEQRGELAIKDAN
P05787	S475	Sugiyama	KRT8 CYK8	TSSSRAVVVKKIETRDGKLVsEssDVLPK____________
P05787	S477	Sugiyama	KRT8 CYK8	SSRAVVVKKIETRDGKLVsEssDVLPK______________
P05787	S478	Sugiyama	KRT8 CYK8	SRAVVVKKIETRDGKLVsEssDVLPK_______________
P06899	S37	Sugiyama	H2BC11 H2BFR HIST1H2BJ	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P07101	S40	SIGNOR	TH TYH	ELDAKQAEAIMVRGQGAPGPsLTGsPWPGTAAPAASYTPTP
P07101	S71	SIGNOR\|EPSD\|PSP	TH TYH	APAASYTPTPRsPRFIGRRQsLIEDARKEREAAVAAAAAAV
P07195	S162	Sugiyama	LDHB	DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195	S303	Sugiyama	LDHB	GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07205	S390	Sugiyama	PGK2 PGKB	VIGGGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPG
P07205	S399	Sugiyama	PGK2 PGKB	CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07355	S184	Sugiyama	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07737	S30	Sugiyama	PFN1	NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814	S739	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07814	S880	Sugiyama	EPRS1 EPRS GLNS PARS QARS QPRS PIG32	LKAQYKEKTGKEyIPGQPPLsQssDssPtRNsEPAGLEtPE
P07864	S161	Sugiyama	LDHC LDH3 LDHX	DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07900	S50	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900	S63	Sugiyama	HSP90AA1 HSP90A HSPC1 HSPCA	IFLRELIsNssDALDKIRyEsLtDPsKLDsGKELHINLIPN
P08174	S106	Sugiyama	CD55 CR DAF	QWSDIEEFCNRSCEVPtRLNsAsLKQPYITQNyFPVGtVVE
P08238	S45	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238	S462	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238	S470	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	RLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItGEs
P08238	S482	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	sGDEMtsLsEyVsRMKEtQKsIyyItGEsKEQVANsAFVER
P08238	S58	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	IFLRELIsNAsDALDKIRyEsLtDPsKLDsGKELKIDIIPN
P08238	Y457	Sugiyama	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P08670	S325	Sugiyama	VIM	NNDALRQAKQESTEYRRQVQsLtCEVDALKGtNEsLERQMR
P09496	S236	Sugiyama	CLTA	RLCDFNPKSSKQAKDVSRMRsVLIsLKQAPLVH________
P09496	S240	Sugiyama	CLTA	FNPKSSKQAKDVSRMRsVLIsLKQAPLVH____________
P09651	S95	Sugiyama	HNRNPA1 HNRPA1	RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P0CG38	S1068	Sugiyama	POTEI	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39	S1031	Sugiyama	POTEJ	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10636	T529	EPSD	MAPT MAPTL MTBT1 TAU	GDRsGyssPGsPGtPGsRsRtPsLPtPPTREPKKVAVVRtP
P10809	S398	Sugiyama	HSPD1 HSP60	LDVttsEyEKEKLNERLAKLsDGVAVLKVGGtsDVEVNEKK
P11142	S40	Sugiyama	HSPA8 HSC70 HSP73 HSPA10	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P11362	S789	SIGNOR\|EPSD\|PSP	FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR	LSMPLDQysPsFPDTRsstCsSGEDsVFSHEPLPEEPCLPR
P12814	S404	Sugiyama	ACTN1	NEIRRLERLDHLAEKFRQKAsIHEAWtDGKEAMLRQKDyEt
P13639	S23	Sugiyama	EEF2 EF2	NFtVDQIRAIMDKKANIRNMsVIAHVDHGKStLtDsLVCKA
P13796	S5	EPSD\|PSP	LCP1 PLS2	________________MARGsVsDEEMMELREAFAKVDtDG
P13798	S8	Sugiyama	APEH D3F15S2 D3S48E DNF15S2	_____________MERQVLLsEPEEAAALyRGLSRQPALsA
P13861	S99	Sugiyama	PRKAR2A PKR2 PRKAR2	EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314	S126	Sugiyama	PRKCSH G19P1	yNsGVICENtCKEKGRKEREsLQQMAEVtREGFRLKKILIE
P14625	S106	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625	S746	Sugiyama	HSP90B1 GRP94 HSPC4 TRA1	GyLLPDTKAYGDRIERMLRLsLNIDPDAKVEEEPEEEPEET
P15311	S539	Sugiyama	EZR VIL2	TEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHNENMR
P15531	S120	Sugiyama	NME1 NDPKA NM23	KPGtIRGDFCIQVGRNIIHGsDsVEsAEKEIGLWFHPEELV
P16104	S140	GPS6	H2AX H2AFX	KtsAtVGPKAPSGGKKAtQAsQEy_________________
P16104	S17	GPS6	H2AX H2AFX	____MSGRGKTGGKARAKAKsRssRAGLQFPVGRVHRLLRK
P16220	S119	SIGNOR\|PSP	CREB1	EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16949	S16	EPSD\|PSP	STMN1 C1orf215 LAP18 OP18	_____MAssDIQVKELEKRAsGQAFELILsPRsKEsVPEFP
P17066	S42	Sugiyama	HSPA6 HSP70B'	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P17812	S573	Sugiyama	CTPS1 CTPS	HYLQKGCRLsPRDtysDRsGsssPDsEItELKFPsINHD__
P18615	S113	Sugiyama	NELFE RD RDBP	EGKLKDPEKGPVPTFQPFQRsIsADDDLQEsSRRPQRKsLy
P18615	S131	Sugiyama	NELFE RD RDBP	QRsIsADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGE
P18621	S5	Sugiyama	RPL17	________________MVRysLDPENPtKsCKSRGSNLRVH
P18848	S245	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	ATF4 CREB2 TXREB	PESYLGSPQHSPSTRGSPNRsLPsPGVLCGSARPKPYDPPG
P19105	S19	PSP	MYL12A MLCB MRLC3 RLC	__MSSKRTKTKTKKRPQRAtsNVFAMFDQSQIQEFKEAFNM
P19338	S458	Sugiyama	NCL	TEADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKN
P19338	S460	Sugiyama	NCL	ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19525	T451	SIGNOR\|EPSD\|PSP	EIF2AK2 PKR PRKR	GDFGLVtsLKNDGKRtRSKGtLRyMsPEQIssQDYGKEVDL
P22059	T377	Sugiyama	OSBP OSBP1	NEFFDAPEIITMPENLGHKRtGsNIsGAssDIsLDEQyKHQ
P22314	S46	Sugiyama	UBA1 A1S9T UBE1	AQsVLsEVPSVPTNGMAKNGsEADIDEGLysRQLyVLGHEA
P22736	S351	SIGNOR\|iPTMNet\|EPSD	NR4A1 GFRP1 HMR NAK1	GMVKEVVRTDsLKGRRGRLPsKPKQPPDAsPANLLtSLVRA
P23527	S37	Sugiyama	H2BC17 H2BFH H2BFN HIST1H2BO	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGISS
P25705	S76	Sugiyama	ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM	EERILGADtsVDLEETGRVLsIGDGIARVHGLRNVQAEEMV
P25788	S243	Sugiyama	PSMA3 HC8 PSC8	GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________
P25963	S32	EPSD\|PSP	NFKBIA IKBA MAD3 NFKBI	AMEGPRDGLKKERLLDDRHDsGLDsMKDEEyEQMVKELQEI
P26038	S527	Sugiyama	MSN	ERTTEAEKNERVQKHLKALtsELANARDEsKKTANDMIHAE
P26232	S654	Sugiyama	CTNNA2 CAPR	EELEDDsDFEQEDYDVRsRtsVQtEDDQLIAGQsARAIMAQ
P26373	S106	Sugiyama	RPL13 BBC1 OK/SW-cl.46	IHKKVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLIL
P26373	S77	Sugiyama	RPL13 BBC1 OK/SW-cl.46	PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P27348	S63	Sugiyama	YWHAQ	LLsVAyKNVVGGRRSAWRVIsSIEQKTDTSDKKLQLIKDYR
P27708	S1859	Sugiyama	CAD	RGIPGLPDGRFHLPPRIHRAsDPGLPAEEPKEKSSRKVAEP
P29317	S897	EPSD\|PSP	EPHA2 ECK	APDSLKTLADFDPRVsIRLPstsGsEGVPFRTVsEWLESIK
P29401	S104	Sugiyama	TKT	AVWAEAGFLAEAELLNLRKIssDLDGHPVPKQAFtDVATGs
P29692	S44	Sugiyama	EEF1D EF1D	RFyEQMNGPVAGAsRQENGAsVILRDIARARENIQKsLAGs
P29692	S60	Sugiyama	EEF1D EF1D	ENGAsVILRDIARARENIQKsLAGssGPGAssGtsGDHGEL
P30050	S138	Sugiyama	RPL12	HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30533	S242	Sugiyama	LRPAP1 A2MRAP	TELKEKLRsINQGLDRLRRVsHQGystEAEFEEPRVIDLWD
P31946	S65	Sugiyama	YWHAB	LLsVAyKNVVGARRSsWRVIsSIEQKTERNEKKQQMGKEYR
P32119	S112	Sugiyama	PRDX2 NKEFB TDPX1	KEGGLGPLNIPLLADVTRRLsEDyGVLKTDEGIAYRGLFII
P32314	S365	SIGNOR\|EPSD\|PSP	FOXN2 HTLF	EGFHSEEDTDVDYEDDPLGDsGYAsQPCAKISEKGQSGKKM
P32314	S369	SIGNOR\|EPSD\|PSP	FOXN2 HTLF	SEEDTDVDYEDDPLGDsGYAsQPCAKISEKGQSGKKMRKQT
P33316	S120	Sugiyama	DUT	PsKRARPAEVGGMQLRFARLsEHAtAPTRGsARAAGYDLYS
P33778	S33	SIGNOR\|EPSD	H2BC3 H2BFF HIST1H2BB	KGsKKAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDT
P33778	S37	Sugiyama	H2BC3 H2BFF HIST1H2BB	KAITKAQKKDGKKRKRsRKEsysIyVyKVLKQVHPDTGISS
P34931	S42	Sugiyama	HSPA1L	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P34932	S76	Sugiyama	HSPA4 APG2 HSPH2	VISNAKNTVQGFKRFHGRAFsDPFVEAEKSNLAYDIVQLPT
P35221	S655	Sugiyama	CTNNA1	PEELDDsDFEtEDFDVRsRtsVQtEDDQLIAGQsARAIMAQ
P35613	S279	Sugiyama	BSG UNQ6505/PRO21383	TDSEDKALMNGSESRFFVsssQGRSELHIENLNMEADPGQy
P35659	S303	Sugiyama	DEK	KKADSSTTKKNQNSSKKEsEsEDssDDEPLIKKLKKPPTDE
P37802	S163	Sugiyama	TAGLN2 KIAA0120 CDABP0035	LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37802	S185	Sugiyama	TAGLN2 KIAA0120 CDABP0035	NQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL______
P37837	S13	Sugiyama	TALDO1 TAL TALDO TALDOR	________MsssPVKRQRMEsALDQLKQFTTVVADTGDFHA
P38646	S148	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	YDDPEVQKDIKNVPFKIVRAsNGDAWVEAHGKLYSPSQIGA
P38646	S89	Sugiyama	HSPA9 GRP75 HSPA9B mt-HSP70	VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39023	S13	Sugiyama	RPL3 OK/SW-cl.32	________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39023	S265	Sugiyama	RPL3 OK/SW-cl.32	HRGLRKVACIGAWHPARVAFsVARAGQKGYHHRTEINKKIY
P40763	S727	EPSD\|PSP	STAT3 APRF	KTKFICVtPttCsNtIDLPMsPRTLDSLMQFGNNGEGAEPS
P42566	S746	Sugiyama	EPS15 AF1P	DFSTLSKVNNEDPFRSATSssVsNVVITKNVFEETSVKSED
P43243	S188	Sugiyama	MATR3 KIAA0723	EPPyRVPRDDWEEKRHFRRDsFDDRGPsLNPVLDyDHGsRs
P43487	S60	Sugiyama	RANBP1	TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P45974	S783	Sugiyama	USP5 ISOT	IDDLDAEAAMDISEGRsAADsIsEsVPVGPKVRDGPGKYQL
P46527	T198	GPS6\|ELM\|EPSD	CDKN1B KIP1 p27	sPNAGSVEQtPKKPGLRRRQt____________________
P46777	S224	Sugiyama	RPL5 MSTP030	VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46783	S146	Sugiyama	RPS10	TYRRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ_
P46937	S109	Sugiyama	YAP1 YAP65	RKLPDsFFKPPEPKsHsRQAstDAGtAGALtPQHVRAHssP
P47712	S727	Sugiyama	PLA2G4A CPLA2 PLA2G4	VIKEAMVESIEyRRQNPsRCsVsLsNVEARRFFNKEFLSKP
P48741	S42	Sugiyama	HSPA7 HSP70B	VFQQGRVEILANDQGNRTtPsyVAFtDtERLVGDAAKsQAA
P48764	S663	EPSD\|PSP	SLC9A3 NHE3	TEDEKQDREIFHRTMRKRLEsFKSTKLGLNQNKKAAKLYKR
P49419	S84	Sugiyama	ALDH7A1 ATQ1	EVIttyCPANNEPIARVRQAsVADyEEtVKKAREAWKIWAD
P49792	T3217	Sugiyama	RANBP2 NUP358	DTVKKIESFGsPKGSVCRRItITECGQI_____________
P49840	S21	SIGNOR\|EPSD\|PSP	GSK3A	MsGGGPsGGGPGGsGRARtssFAEPGGGGGGGGGGPGGsAs
P49841	S9	GPS6\|EPSD\|PSP	GSK3B	____________MSGRPRttsFAEsCKPVQQPsAFGsMKVS
P50454	S139	Sugiyama	SERPINH1 CBP1 CBP2 HSP47 SERPINH2 PIG14	SNSTARNVTWKLGsRLyGPssVsFADDFVRssKQHYNCEHS
P51116	S601	Sugiyama	FXR2 FMR1L2	RPQRRNRSRRRRNRGNRtDGsIsGDRQPVtVADyIsRAEsQ
P51812	S227	iPTMNet\|EPSD	RPS6KA3 ISPK1 MAPKAPK1B RSK2	IKLTDFGLSKESIDHEKKAysFCGtVEYMAPEVVNRRGHTQ
P51812	S369	iPTMNet\|EPSD	RPS6KA3 ISPK1 MAPKAPK1B RSK2	GRPEDTFYFDPEFTAKtPKDsPGIPPsANAHQLFRGFsFVA
P51812	S386	GPS6\|EPSD	RPS6KA3 ISPK1 MAPKAPK1B RSK2	PKDsPGIPPsANAHQLFRGFsFVAItsDDESQAMQTVGVHS
P51812	S415	Sugiyama	RPS6KA3 ISPK1 MAPKAPK1B RSK2	ESQAMQTVGVHSIVQQLHRNsIQFTDGYEVKEDIGVGsysV
P51812	S432	Sugiyama	RPS6KA3 ISPK1 MAPKAPK1B RSK2	HRNsIQFTDGYEVKEDIGVGsysVCKRCIHKATNMEFAVKI
P51812	S434	Sugiyama	RPS6KA3 ISPK1 MAPKAPK1B RSK2	NsIQFTDGYEVKEDIGVGsysVCKRCIHKATNMEFAVKIID
P51812	S708	Sugiyama	RPS6KA3 ISPK1 MAPKAPK1B RSK2	YQLNRQDAPHLVKGAMAAtysALNRNQsPVLEPVGRsTLAQ
P51812	S715	iPTMNet\|EPSD\|Sugiyama	RPS6KA3 ISPK1 MAPKAPK1B RSK2	APHLVKGAMAAtysALNRNQsPVLEPVGRsTLAQRRGIKKI
P51812	S724	Sugiyama	RPS6KA3 ISPK1 MAPKAPK1B RSK2	AAtysALNRNQsPVLEPVGRsTLAQRRGIKKITSTAL____
P51812	T231	iPTMNet\|EPSD	RPS6KA3 ISPK1 MAPKAPK1B RSK2	DFGLSKESIDHEKKAysFCGtVEYMAPEVVNRRGHTQSADW
P51812	T365	iPTMNet\|EPSD	RPS6KA3 ISPK1 MAPKAPK1B RSK2	KPATGRPEDTFYFDPEFTAKtPKDsPGIPPsANAHQLFRGF
P51812	T581	iPTMNet\|EPSD	RPS6KA3 ISPK1 MAPKAPK1B RSK2	DFGFAKQLRAENGLLMtPCytANFVAPEVLKRQGYDAACDI
P51812	T706	Sugiyama	RPS6KA3 ISPK1 MAPKAPK1B RSK2	PQYQLNRQDAPHLVKGAMAAtysALNRNQsPVLEPVGRsTL
P51812	Y707	Sugiyama	RPS6KA3 ISPK1 MAPKAPK1B RSK2	QYQLNRQDAPHLVKGAMAAtysALNRNQsPVLEPVGRsTLA
P51858	S107	Sugiyama	HDGF HMG1L2	WEIENNPtVKASGYQSsQKKsCVEEPEPEPEAAEGDGDKKG
P53355	S289	GPS6\|ELM\|EPSD\|PSP	DAPK1 DAPK	SLQHPWIKPKDTQQALSRKAsAVNMEKFKKFAARKKWKQsV
P53365	S260	Sugiyama	ARFIP2 POR1	TDLEELsLGPRDAGTRGRLEsAQATFQAHRDKYEKLRGDVA
P53396	S455	Sugiyama	ACLY	ANFLLNAsGststPAPsRtAsFsEsRADEVAPAKKAKPAMP
P53621	S266	Sugiyama	COPA	RGHyNNVSCAVFHPRQELILsNsEDKSIRVWDMSKRTGVQT
P53999	S56	Sugiyama	SUB1 PC4 RPO2TC1	PVKKQKTGETsRALsssKQssssRDDNMFQIGKMRYVSVRD
P54652	S41	Sugiyama	HSPA2	VFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKNQVA
P57053	S37	Sugiyama	H2BC12L H2BFS H2BS1	KAVTKAQKKDGRKRKRSRKEsysVyVyKVLKQVHPDTGIss
P58876	S37	Sugiyama	H2BC5 H2BFB HIRIP2 HIST1H2BD	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
P60174	S195	Sugiyama	TPI1 TPI	KtATPQQAQEVHEKLRGWLKsNVsDAVAQstRIIyGGsVtG
P60174	S212	Sugiyama	TPI1 TPI	WLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLV
P60709	S199	Sugiyama	ACTB	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709	S368	Sugiyama	ACTB	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709	S52	Sugiyama	ACTB	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60900	S175	Sugiyama	PSMA6 PROS27	DPAGyyCGFKATAAGVKQtEstsFLEKKVKKKFDWTFEQTV
P61024	S39	Sugiyama	CKS1B CKS1 PNAS-143 PNAS-16	yRHVMLPKDIAKLVPKTHLMsEsEWRNLGVQQsQGWVHyMI
P61247	S236	Sugiyama	RPS3A FTE1 MFTL	KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61313	S100	Sugiyama	RPL15 EC45 TCBAP0781	tyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLNsyW
P61916	S29	Sugiyama	NPC2 HE1	LLLALSTAAQAEPVQFKDCGsVDGVIKEVNVsPCPtQPCQL
P61978	S401	Sugiyama	HNRNPK HNRPK	GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978	S75	Sugiyama	HNRNPK HNRPK	GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61981	S64	Sugiyama	YWHAG	LLsVAyKNVVGARRSsWRVIsSIEQKtsADGNEKKIEMVRA
P62249	S9	Sugiyama	RPS16	____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62263	S137	Sugiyama	RPS14 PRO2640	RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62269	S96	Sugiyama	RPS18 D6S218E	QYKIPDWFLNRQKDVKDGKysQVLANGLDNKLREDLERLKK
P62277	S12	Sugiyama	RPS13	_________MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDD
P62277	S14	Sugiyama	RPS13	_______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62304	S89	Sugiyama	SNRPE	KSRKQLGRIMLKGDNITLLQsVsN_________________
P62736	S54	Sugiyama	ACTA2 ACTSA ACTVS GIG46	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62753	S235	GPS6\|EPSD\|PSP	RPS6 OK/SW-cl.2	KRMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK______
P62753	S236	GPS6\|EPSD\|PSP	RPS6 OK/SW-cl.2	RMKEAKEKRQEQIAKRRRLssLRAstsKsEssQK_______
P62807	S37	Sugiyama	H2BC4 H2BFL HIST1H2BC; H2BC6 H2BFH HIST1H2BE; H2BC7 H2BFG HIST1H2BF; H2BC8 H2BFA HIST1H2BG; H2BC10 H2BFK HIST1H2BI	KAVTKAQKKDGKKRKRsRKEsysVyVyKVLKQVHPDTGIss
P62906	S64	Sugiyama	RPL10A NEDD6	QKDKRFsGTVRLKSTPRPKFsVCVLGDQQHCDEAKAVDIPH
P62917	S130	Sugiyama	RPL8	GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62937	T157	Sugiyama	PPIA CYPA	NIVEAMERFGsRNGKTSKKItIADCGQLE____________
P62979	S123	Sugiyama	RPS27A UBA80 UBCEP1	LKYYKVDENGKIsRLRRECPsDECGAGVFMAsHFDRHyCGK
P63104	S28	Sugiyama	YWHAZ	QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104	T30	Sugiyama	YWHAZ	AKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAyKN
P63261	S199	Sugiyama	ACTG1 ACTG	DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261	S368	Sugiyama	ACTG1 ACTG	sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261	S52	Sugiyama	ACTG1 ACTG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63267	S53	Sugiyama	ACTG2 ACTA3 ACTL3 ACTSG	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P67809	S102	SIGNOR\|EPSD\|PSP\|Sugiyama	YBX1 NSEP1 YB1	EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809	S136	Sugiyama	YBX1 NSEP1 YB1	GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809	T108	Sugiyama	YBX1 NSEP1 YB1	QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809	Y99	Sugiyama	YBX1 NSEP1 YB1	DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P68032	S54	Sugiyama	ACTC1 ACTC	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133	S54	Sugiyama	ACTA1 ACTA	PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68363	S439	Sugiyama	TUBA1B	SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
P68431	S11	GPS6\|SIGNOR\|EPSD	H3C1 H3FA HIST1H3A; H3C2 H3FL HIST1H3B; H3C3 H3FC HIST1H3C; H3C4 H3FB HIST1H3D; H3C6 H3FD HIST1H3E; H3C7 H3FI HIST1H3F; H3C8 H3FH HIST1H3G; H3C10 H3FK HIST1H3H; H3C11 H3FF HIST1H3I; H3C12 H3FJ HIST1H3J	__________MARtKQtARKstGGKAPRKQLATKAARKsAP
P78371	S143	Sugiyama	CCT2 99D8.1 CCTB	PQTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIA
P84098	S12	Sugiyama	RPL19	_________MSMLRLQKRLAssVLRCGKKKVWLDPNEtNEI
P84243	S11	GPS6\|SIGNOR	H3-3A H3.3A H3F3 H3F3A PP781; H3-3B H3.3B H3F3B	__________MARtKQTARKstGGKAPRKQLATKAARKsAP
Q00610	S147	Sugiyama	CLTC CLH17 CLTCL2 KIAA0034	VYHWSMEGESQPVKMFDRHssLAGCQIINYRTDAKQKWLLL
Q01105	S161	Sugiyama	SET	FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105	S168	Sugiyama	SET	ENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQN
Q02818	S193	Sugiyama	NUCB1 NUC	HEEFKRyEMLKEHERRRyLEsLGEEQRKEAERKLEEQQRRH
Q04206	S276	PSP	RELA NFKB3	PYADPsLQAPVRVsMQLRRPsDRELsEPMEFQYLPDTDDRH
Q04917	S64	Sugiyama	YWHAH YWHA1	LLsVAyKNVVGARRSsWRVIsSIEQKTMADGNEKKLEKVKA
Q05195	S145	GPS6	MXD1 MAD	EQRHLKRQLEKLGIERIRMDsIGSTVSSERSDSDREEIDVD
Q06413	S192	GPS6\|ELM\|EPSD	MEF2C	LAHPSLQRNsMsPGVtHRPPsAGNtGGLMGGDLTSGAGTSA
Q07021	S213	Sugiyama	C1QBP GC1QBP HABP1 SF2P32	VGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDSLDW
Q07866	S524	Sugiyama	KLC1 KLC KNS2	QRVAEVLNDPENMEKRRsREsLNVDVVKYESGPDGGEEVSM
Q09161	S22	Sugiyama	NCBP1 CBP80 NCBP	SRRRHsDENDGGQPHKRRKtsDANEtEDHLEsLICKVGEKS
Q09666	S135	Sugiyama	AHNAK PM227	sGDDEEyQRIYttKIKPRLKsEDGVEGDLGEtQsRTITVTR
Q13247	S297	Sugiyama	SRSF6 SFRS6 SRP55	RSRSPKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsP
Q13247	S301	Sugiyama	SRSF6 SFRS6 SRP55	PKENGKGDIKsKSRsRsQsRsNsPLPVPPsKARsVsPPPKR
Q13428	S85	Sugiyama	TCOF1	AEEDAALQAKKTRVsDPIstsEssEEEEEAEAETAKAtPRL
Q13442	S57	Sugiyama	PDAP1 HASPP28	EEEQKEGGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGV
Q13442	S60	Sugiyama	PDAP1 HASPP28	QKEGGDGAAGDPKKEKKsLDsDEsEDEEDDyQQKRKGVEGL
Q13765	S132	Sugiyama	NACA HSD48	YKSPAsDtyIVFGEAKIEDLsQQAQLAAAEKFKVQGEAVsN
Q14152	S584	Sugiyama	EIF3A EIF3S10 KIAA0139	EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14152	S988	Sugiyama	EIF3A EIF3S10 KIAA0139	PRRGPEEDRFsRRGADDDRPsWRNTDDDRPPRRIADEDRGN
Q14568	S50	Sugiyama	HSP90AA2P HSP90AA2 HSPC2 HSPCAL3	MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14671	S709	Sugiyama	PUM1 KIAA0099 PUMH1	LGGFGTAVANSNTGSGSRRDsLtGSsDLYKRTSSSLTPIGH
Q14697	S169	Sugiyama	GANAB G2AN KIAA0088	IILTARPFRLDLLEDRSLLLsVNARGLLEFEHQRAPRVsQG
Q14697	S187	Sugiyama	GANAB G2AN KIAA0088	LLsVNARGLLEFEHQRAPRVsQGsKDPAEGDGAQPEEtPRD
Q14697	S190	Sugiyama	GANAB G2AN KIAA0088	VNARGLLEFEHQRAPRVsQGsKDPAEGDGAQPEEtPRDGDK
Q14790	T263	SIGNOR\|EPSD\|PSP	CASP8 MCH5	NFAKAREKVPKLHSIRDRNGtHLDAGALTTtFEELHFEIKP
Q14934	S281	SIGNOR\|EPSD\|PSP	NFATC4 NFAT3	RPAsPCGKRRYsssGtPssAsPALsRRGsLGEEGsEPPPPP
Q14934	S285	SIGNOR\|EPSD\|PSP	NFATC4 NFAT3	PCGKRRYsssGtPssAsPALsRRGsLGEEGsEPPPPPPLPL
Q14934	S289	GPS6\|SIGNOR\|EPSD\|PSP	NFATC4 NFAT3	RRYsssGtPssAsPALsRRGsLGEEGsEPPPPPPLPLARDP
Q14934	S334	GPS6\|EPSD	NFATC4 NFAT3	PFDyVGAPPAESIPQKtRRtssEQAVALPRsEEPASCNGKL
Q14934	S344	SIGNOR\|EPSD\|PSP	NFATC4 NFAT3	ESIPQKtRRtssEQAVALPRsEEPASCNGKLPLGAEESVAP
Q14934	S676	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	NFATC4 NFAT3	KRVSRPVQVYFYVSNGRRKRsPTQSFRFLPVICKEEPLPDS
Q15021	S1330	Sugiyama	NCAPD2 CAPD2 CNAP1 KIAA0159	sQRAPsAKKPSTGSRyQPLAstAsDNDFVtPEPRRTTRRHP
Q15021	T1331	Sugiyama	NCAPD2 CAPD2 CNAP1 KIAA0159	QRAPsAKKPSTGSRyQPLAstAsDNDFVtPEPRRTTRRHPN
Q15029	S944	Sugiyama	EFTUD2 KIAA0031 SNRP116	QPAPHLAREFMIKTRRRKGLsEDVsIsKFFDDPMLLELAKQ
Q15349	S425	Sugiyama	RPS6KA2 MAPKAPK1C RSK3	HGNNIHFTDGYEIKEDIGVGsysVCKRCVHKAtDTEYAVKI
Q15349	S427	Sugiyama	RPS6KA2 MAPKAPK1C RSK3	NNIHFTDGYEIKEDIGVGsysVCKRCVHKAtDTEYAVKIID
Q15428	S153	Sugiyama	SF3A2 SAP62	LFQIDYPEIAEGIMPRHRFMsAyEQRIEPPDRRWQYLLMAA
Q15642	S296	Sugiyama	TRIP10 CIP4 STOT STP	FARPGDVEFEDFsQPMNRAPsDssLGtPsDGRPELRGPGRS
Q15818	S91	Sugiyama	NPTX1	TILSQKETIRELTAKLGRCEsQsTLDPGAGEARAGGGRKQP
Q15831	S428	iPTMNet\|EPSD	STK11 LKB1 PJS	GRAPNPARKACSASSKIRRLsACKQQ_______________
Q16204	S323	Sugiyama	CCDC6 D10S170 TST1	RLQRKLQREMERREALCRQLsEsEssLEMDDERYFNEMsAQ
Q16513	S583	Sugiyama	PKN2 PRK2 PRKCL2	VTKLDFDLEPEPPPAPPRAssLGEIDEssELRVLDIPGQDs
Q16695	S11	iPTMNet\|EPSD	H3-4 H3FT HIST3H3	__________MARtKQTARKsTGGKAPRKQLATKVARKsAP
Q16778	S37	Sugiyama	H2BC21 H2BFQ HIST2H2BE	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKQVHPDTGIss
Q16821	S46	EPSD\|PSP	PPP1R3A PP1G	CEDEEVTFQPGFSPQPSRRGsDsSEDIYLDTPSSGTRRVsF
Q16821	S65	EPSD\|PSP	PPP1R3A PP1G	GsDsSEDIYLDTPSSGTRRVsFADSFGFNLVSVKEFDCWEL
Q32MZ4	S766	Sugiyama	LRRFIP1 GCF2 TRIP	sTERCEMSEHPSQTVRKALDsNsLENDDLSAPGREPGHFNP
Q32P51	S95	Sugiyama	HNRNPA1L2 HNRNPA1L	TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q4G0J3	S258	Sugiyama	LARP7 HDCMA18P	EENMDtsNtsIsKMKRsRPtsEGsDIEstEPQKQCSKKKKK
Q53EL6	S76	Sugiyama	PDCD4 H731	NAKAKRRLRKNssRDsGRGDsVsDsGsDALRSGLtVPtsPK
Q58FF6	S34	Sugiyama	HSP90AB4P	IFLQELISNASDALDKIRyEsLtDPsKLDGGKELKIDIIPN
Q58FF7	S58	Sugiyama	HSP90AB3P HSP90BC	IFLQELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q58FF8	S258	Sugiyama	HSP90AB2P HSP90BB	LAVRYFSVEEYVSRMKEIQKsIyyItGEsKEQVANSAFVEQ
Q58FF8	S58	Sugiyama	HSP90AB2P HSP90BB	IFLWELISNASDALDKIRyEsLtDPsKLDsGKELKIDIIPN
Q5QNW6	S37	Sugiyama	H2BC18 HIST2H2BF	KAVTKVQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q5T0N5	S488	Sugiyama	FNBP1L C1orf39 TOCA1	NEAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytD
Q5T0N5	S489	Sugiyama	FNBP1L C1orf39 TOCA1	EAWLSEVEGKTGGRGDRRHssDINHLVtQGREsPEGsytDD
Q5T1M5	S1162	Sugiyama	FKBP15 KIAA0674	EAGstVAGAALRPsHHsQRssLsGDEEDELFKGATLKALRP
Q5T5C0	S692	Sugiyama	STXBP5 LLGL3	YGSNDPYRREPRSPRKsRQPsGAGLCDIsEGtVVPEDRCKS
Q6DN03	S37	Sugiyama	H2BC20P HIST2H2BC	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6DRA6	S37	Sugiyama	H2BC19P HIST2H2BD	KAVTKAQKKDGKKRKRSRKEsysIyVyKVLKRVHPDTGIWC
Q6GYQ0	S797	Sugiyama	RALGAPA1 GARNL1 KIAA0884 TULIP1	EtGNEVFGALNEEQPLPRssstsDILEPFTVERAKVNKEDM
Q6P996	S722	Sugiyama	PDXDC1 KIAA0251	PGQKPFKRsLRGsDALsEtssVsHIEDLEKVERLssGPEQI
Q6S8J3	S1068	Sugiyama	POTEE A26C1A POTE2	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6ZMR3	S161	Sugiyama	LDHAL6A LDHL2	DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZN18	S206	Sugiyama	AEBP2	DEGYGTGGGGSSATSGGRRGsLEMssDGEPLSRMDSEDSIS
Q71DI3	S11	GPS6	H3C15 HIST2H3A; H3C14 H3F2 H3FM HIST2H3C; H3C13 HIST2H3D	__________MARtKQTARKsTGGKAPRKQLATKAARKsAP
Q71U36	S439	Sugiyama	TUBA1A TUBA3	SEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy________
Q7KZ85	S125	Sugiyama	SUPT6H KIAA0162 SPT6H	EENLGVKVKRGQKYRRVKKMsDDEDDDEEEYGKEEHEKEAI
Q7Z417	S652	Sugiyama	NUFIP2 KIAA1321 PIG1	NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z4V5	S369	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	EKERRRERADRGEAERGsGGssGDELREDDEPVKKRGRKGR
Q7Z4V5	S395	Sugiyama	HDGFL2 HDGF2 HDGFRP2 HRP2 UNQ785/PRO1604	REDDEPVKKRGRKGRGRGPPsssDsEPEAELEREAKKSAKK
Q7Z5L9	S15	Sugiyama	IRF2BP2	______MAAAVAVAAASRRQsCyLCDLPRMPWAMIWDFTEP
Q86VQ1	S223	Sugiyama	GLCCI1	QTPsCWAEEGAEKRSHQRsAsWGsADQLKEQIAKLRQQLQR
Q86W92	S630	Sugiyama	PPFIBP1 KIAA1230	SEPEFKRGGTRATAGPRLGWsRDLGQsNsDLDMPFAKWTKE
Q8IX03	S947	SIGNOR\|EPSD\|PSP	WWC1 KIAA0869 KIBRA	sKtFsPGPQSQYVCRLNRsDsDsSTLSKKPPFVRNSLERRS
Q8IX03	T929	SIGNOR\|EPSD\|PSP	WWC1 KIAA0869 KIBRA	RVGtPsQGPFLRGSTIIRsKtFsPGPQSQYVCRLNRsDsDs
Q8N122	S719	GPS6	RPTOR KIAA1303 RAPTOR	TTEGGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSL
Q8N122	S721	GPS6	RPTOR KIAA1303 RAPTOR	EGGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSLQN
Q8N122	S722	GPS6	RPTOR KIAA1303 RAPTOR	GGSLtPVRDsPCtPRLRsVssYGNIRAVATARSLNKSLQNL
Q8N201	S495	Sugiyama	INTS1 KIAA1440 UNQ1821/PRO3434	KFLAMVFQDLLTNKDDYLRAsRALLREIIKQTKHEINFQAF
Q8N257	S37	Sugiyama	H2BC26 H2BU1 HIST3H2BB	KAVTKAQKKDGKKRKRGRKEsysIyVyKVLKQVHPDTGIss
Q8N8S7	S125	Sugiyama	ENAH MENA	MHALEVLNSQETGPTLPRQNsQLPAQVQNGPSQEELEIQRR
Q8NBJ7	S256	Sugiyama	SUMF2 PSEC0171 UNQ1968/PRO4500	EWTASPYQAAEQDMRVLRGAsWIDtADGsANHRARVttRMG
Q8NFD5	S1744	Sugiyama	ARID1B BAF250B DAN15 KIAA1235 OSA2	ALDTINILLYDDSTVATFNLsQLSGFLELLVEYFRKCLIDI
Q8TEW0	S962	Sugiyama	PARD3 PAR3 PAR3A	DEGMEtLEEDTEESSRsGREsVstAsDQPsHsLERQMNGNQ
Q92597	S330	Sugiyama	NDRG1 CAP43 DRG1 RTP	QGMGYMPsAsMtRLMRsRtAsGssVtsLDGtRsRsHtSEGT
Q92734	S50	Sugiyama	TFG	DITyDELVLMMQRVFRGKLLsNDEVTIKYKDEDGDLITIFD
Q92934	S75	GPS6\|SIGNOR\|ELM\|EPSD\|PSP	BAD BBC6 BCL2L8	PTSSSHHGGAGAVEIRsRHssyPAGtEDDEGMGEEPsPFRG
Q92934	S99	EPSD\|PSP	BAD BBC6 BCL2L8	GtEDDEGMGEEPsPFRGRsRsAPPNLWAAQRYGRELRRMsD
Q93079	S37	Sugiyama	H2BC9 H2BFJ HIST1H2BH	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q96CV9	S526	Sugiyama	OPTN FIP2 GLC1E HIP7 HYPL NRP	FEDGGRQsLMEMQsRHGARtsDsDQQAyLVQRGAEDRDWRQ
Q96RU3	Y500	Sugiyama	FNBP1 FBP17 KIAA0554	AEVEGRLPARSEQARRQsGLyDSQNPPTVNNCAQDREsPDG
Q99543	S275	Sugiyama	DNAJC2 MPHOSPH11 MPP11 ZRF1	RAQRKKEEMNRIRtLVDNAysCDPRIKKFKEEEKAKKEAEK
Q99613	S865	Sugiyama	EIF3C EIF3S8	HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99683	S83	SIGNOR\|EPSD\|PSP	MAP3K5 ASK1 MAPKKK5 MEKK5	PGIGCPAATSSSSATRGRGSsVGGGSRRTTVAYVINEASQG
Q99683	T1109	SIGNOR\|EPSD\|PSP	MAP3K5 ASK1 MAPKKK5 MEKK5	TLIASLREFVRSTDRKIIATtLSKLKLELDFDSHGISQVQV
Q99683	T1326	SIGNOR\|EPSD\|PSP	MAP3K5 ASK1 MAPKKK5 MEKK5	TNTEDSELTDWLRVNGADEDtISRFLAEDYTLLDVLYYVTR
Q99877	S37	Sugiyama	H2BC15 H2BFD HIST1H2BN	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99879	S37	Sugiyama	H2BC14 H2BFE HIST1H2BM	KAINKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99880	S37	Sugiyama	H2BC13 H2BFC HIST1H2BL	KAVTKAQKKDGKKRKRSRKEsysVyVyKVLKQVHPDTGIss
Q99990	S84	SIGNOR\|PSP	VGLL1 TDU	SEGVMLKNDDSMSPNQWRYSsPWTKPQPEVPVTNRAANCNL
Q9BQA1	S185	Sugiyama	WDR77 MEP50 WD45 HKMT1069 Nbla10071	AHAAQVTCVAAsPHKDSVFLsCSEDNRILLWDTRCPKPASQ
Q9BQG0	S1186	Sugiyama	MYBBP1A P160	sKKRKKKGFLPETKKRKKRKsEDGtPAEDGtPAATGGsQPP
Q9BSI4	S295	SIGNOR\|EPSD\|PSP	TINF2 TIN2	TRGGHKERPTVMLFPFRNLGsPtQVISKPEsKEEHAIYTAD
Q9BSI4	S330	SIGNOR\|EPSD\|PSP	TINF2 TIN2	AIYTADLAMGTRAASTGKSKsPCQTLGGRALKENPVDLPAT
Q9BVS4	S483	PSP	RIOK2 RIO2	RPFRDEENVGAMNQYRTRtLsItssGsAVSCSTIPPELVKQ
Q9BWH6	T1384	Sugiyama	RPAP1 KIAA1403	FELYSQLPPLRQHYLQRLTStVLQNGVSET___________
Q9BY44	S526	Sugiyama	EIF2A CDA02 MSTP004 MSTP089	sPDLAPtPAPQstPRNtVsQsIsGDPEIDKKIKNLKKKLKA
Q9BYX7	S368	Sugiyama	POTEKP ACTBL3 FKSG30	SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BZI7	S166	Sugiyama	UPF3B RENT3B UPF3X	KRDTKVGtIDDDPEyRKFLEsyAtDNEKMTstPEtLLEEIE
Q9C0C2	S1616	Sugiyama	TNKS1BP1 KIAA1741 TAB182	LSEAADsDAHLFQDSTEPRAsRVPssDEEVVEEPQsRRTRM
Q9C0C2	S429	Sugiyama	TNKS1BP1 KIAA1741 TAB182	EEEAKGDAHLRPtsLVQRRFsEGVLQsPsQDQEKLGGsLAA
Q9H2U2	S313	Sugiyama	PPA2 HSPC124	VQISDSPFRCtQEEARsLVEsVsssPNKEsNEEEQVWHFLG
Q9H6Z4	S126	EPSD\|PSP	RANBP3	EDsDREDGNyCPPVKRERtssLtQFPPSQSEERSSGFRLKP
Q9H6Z4	S57	SIGNOR	RANBP3	SGEEPRGEAEAPHHGTGHPEsAGEHALEPPAPAGASASTPP
Q9H788	S315	Sugiyama	SH2D4A PPP1R38 SH2A	LNSGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRA
Q9H788	S317	Sugiyama	SH2D4A PPP1R38 SH2A	SGAYPQKPLRNQGVVRtLsssAQEDIIRWFKEEQLPLRAGY
Q9HCN4	S301	Sugiyama	GPN1 MBDIN RPAP4 XAB1 HUSSY-23	ANAESQQQREQLERLRKDMGsVALDAGtAKDsLsPVLHPsD
Q9NQ39	S157	Sugiyama	RPS10P5 RPS10L	TYRRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ_
Q9NRA8	S353	Sugiyama	EIF4ENIF1	SASRFSRWFSNPsRsGsRsssLGstPHEELERLAGLEQAIL
Q9NTI5	S1257	Sugiyama	PDS5B APRIN AS3 KIAA0979	LVQEQKPKGSQRSRKRGHtAsEsDEQQWPEEKRLKEDILEN
Q9NUU7	T467	Sugiyama	DDX19A DDX19L	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9NW13	S200	Sugiyama	RBM28	KGRTVAVDWAVAKDKYKDTQsVsAIGEEKSHESKHQESVKK
Q9NY33	S130	Sugiyama	DPP3	GDTKFVPNLPKEKLERVILGsEAAQQHPEEVRGLWQTCGEL
Q9NYV6	S649	GPS6\|ELM\|EPSD\|PSP	RRN3 TIFIA	tHFRsPsssVGsPPVLyMQPsPL__________________
Q9UBP6	S27	GPS6\|Sugiyama	METTL1 C12orf1	NVAGAEAPPPQKRYYRQRAHsNPMADHTLRYPVKPEEMDWS
Q9UGV2	S331	Sugiyama	NDRG3	QGMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQ
Q9UGV2	T332	Sugiyama	NDRG3	GMGYIPSASMTRLARsRtHstsssLGsGEsPFsRsVtsNQs
Q9UI15	S185	Sugiyama	TAGLN3 NP25	EQLRQGQNVIGLQMGSNKGAsQAGMtGyGMPRQIM______
Q9UK32	S436	Sugiyama	RPS6KA6 RSK4	NGNAAQFGEVYELKEDIGVGsysVCKRCIHATTNMEFAVKI
Q9UK32	S438	Sugiyama	RPS6KA6 RSK4	NAAQFGEVYELKEDIGVGsysVCKRCIHATTNMEFAVKIID
Q9UL17	S503	EPSD\|PSP	TBX21 TBET TBLYM	IRPESSDSGLGEGDSKRRRVsPyPsSGDSSSPAGAPSPFDK
Q9UL17	S507	EPSD\|PSP	TBX21 TBET TBLYM	SSDSGLGEGDSKRRRVsPyPsSGDSSSPAGAPSPFDKEAEG
Q9ULD2	T1204	Sugiyama	MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1	ENEELKARMDKHMAISRQLstEQAVLQESLEKESKVNKRLs
Q9UMR2	T468	Sugiyama	DDX19B DBP5 DDX19 TDBP	SMNILNRIQEHFNKKIERLDtDDLDEIEKIAN_________
Q9UPQ0	S377	Sugiyama	LIMCH1 KIAA1102	LREEDDKWQDDLARWKSRRRsVsQDLIKKEEERKKMEKLLA
Q9UQ35	S1541	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ssVDQKtVARtPLGQRsRsGssQELDVKPsAsPQERsEsDs
Q9UQ35	S2692	Sugiyama	SRRM2 KIAA0324 SRL300 SRM300 HSPC075	ERRSRSPRKPIDsLRDsRsLsysPVERRRPsPQPsPRDQQS
Q9Y2B0	S65	Sugiyama	CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426	VDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLEEI
Q9Y2I7	S307	Sugiyama	PIKFYVE KIAA0981 PIP5K3	TRLVSVQEDAGKsPARNRsAsItNLsLDRsGsPMVPSYEts
Q9Y2T7	S137	Sugiyama	YBX2 CSDA3 MSY2	EDVFVHQtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEA
Q9Y2T7	T143	Sugiyama	YBX2 CSDA3 MSY2	QtAIKRNNPRKFLRsVGDGEtVEFDVVEGEKGAEATNVTGP
Q9Y5K3	S260	GPS6	PCYT1B CCTB	YRFQNQVDKMKEKVKNVEERsKEFVNRVEEKSHDLIQKWEE
Q9Y5S9	S56	Sugiyama	RBM8A RBM8 HSPC114 MDS014	KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y6D5	S277	Sugiyama	ARFGEF2 ARFGEP2 BIG2	RSDSGKVSTENGDAPRERGssLsGtDDGAQEVVKDILEDVV

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
Chromatin modifying enzymes	R-HSA-3247509	3.952156e-09	8.403	0	0
Chromatin organization	R-HSA-4839726	1.450220e-08	7.839	0	0
Cell Cycle	R-HSA-1640170	2.525979e-06	5.598	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	3.263573e-06	5.486	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	3.479034e-06	5.459	0	0
G alpha (12/13) signalling events	R-HSA-416482	4.118136e-06	5.385	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	7.086214e-06	5.150	0	0
Cell Cycle Checkpoints	R-HSA-69620	7.351961e-06	5.134	0	0
NRAGE signals death through JNK	R-HSA-193648	7.936338e-06	5.100	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	8.738115e-06	5.059	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	9.616203e-06	5.017	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	1.249355e-05	4.903	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.214756e-05	4.916	0	0
Signal Transduction	R-HSA-162582	1.658716e-05	4.780	1	0
Mitotic Prophase	R-HSA-68875	2.213591e-05	4.655	0	0
Estrogen-dependent gene expression	R-HSA-9018519	2.699297e-05	4.569	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	3.032353e-05	4.518	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.188852e-05	4.496	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.802551e-05	4.420	0	0
G2/M DNA damage checkpoint	R-HSA-69473	4.089760e-05	4.388	0	0
Cell Cycle, Mitotic	R-HSA-69278	4.283477e-05	4.368	0	0
PKMTs methylate histone lysines	R-HSA-3214841	5.682034e-05	4.245	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	5.854381e-05	4.233	0	0
Cellular Senescence	R-HSA-2559583	8.144971e-05	4.089	1	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	8.858462e-05	4.053	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	8.795564e-05	4.056	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	8.574974e-05	4.067	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	9.084652e-05	4.042	0	0
HATs acetylate histones	R-HSA-3214847	1.061805e-04	3.974	0	0
mRNA 3'-end processing	R-HSA-72187	2.647823e-04	3.577	0	0
Signaling by Hippo	R-HSA-2028269	2.783696e-04	3.555	0	0
Meiotic synapsis	R-HSA-1221632	3.211487e-04	3.493	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	3.357822e-04	3.474	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	3.401978e-04	3.468	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	3.603662e-04	3.443	0	0
Gene expression (Transcription)	R-HSA-74160	3.663458e-04	3.436	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	3.687405e-04	3.433	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	3.901975e-04	3.409	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	4.450582e-04	3.352	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	4.450582e-04	3.352	0	0
HDACs deacetylate histones	R-HSA-3214815	4.657757e-04	3.332	0	0
mRNA Splicing	R-HSA-72172	5.019807e-04	3.299	0	0
Regulation of TP53 Activity	R-HSA-5633007	4.987823e-04	3.302	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	4.939134e-04	3.306	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	5.111297e-04	3.291	0	0
Packaging Of Telomere Ends	R-HSA-171306	5.293000e-04	3.276	0	0
PRC2 methylates histones and DNA	R-HSA-212300	5.610474e-04	3.251	0	0
DNA Double Strand Break Response	R-HSA-5693606	5.481845e-04	3.261	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	6.425886e-04	3.192	0	0
M Phase	R-HSA-68886	7.501778e-04	3.125	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	8.392753e-04	3.076	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	8.822751e-04	3.054	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	9.205230e-04	3.036	1	1
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	1.059502e-03	2.975	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.098023e-03	2.959	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	1.178135e-03	2.929	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.496504e-03	2.825	0	0
RNA Polymerase II Transcription	R-HSA-73857	1.507396e-03	2.822	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.690936e-03	2.772	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.730251e-03	2.762	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	1.730251e-03	2.762	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	1.750330e-03	2.757	0	0
Germ layer formation at gastrulation	R-HSA-9754189	2.056443e-03	2.687	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.135245e-03	2.671	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	2.135245e-03	2.671	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	2.052189e-03	2.688	0	0
Diseases of programmed cell death	R-HSA-9645723	2.294292e-03	2.639	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.461417e-03	2.609	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	2.355751e-03	2.628	0	0
ESR-mediated signaling	R-HSA-8939211	2.355627e-03	2.628	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	2.407907e-03	2.618	0	0
DNA methylation	R-HSA-5334118	2.733772e-03	2.563	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.643507e-03	2.578	0	0
Axon guidance	R-HSA-422475	2.610003e-03	2.583	1	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	2.685844e-03	2.571	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	2.943489e-03	2.531	0	0
Death Receptor Signaling	R-HSA-73887	3.334636e-03	2.477	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	3.447727e-03	2.462	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	3.516623e-03	2.454	0	0
Nucleosome assembly	R-HSA-774815	3.759160e-03	2.425	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	3.759160e-03	2.425	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	3.835661e-03	2.416	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	4.177110e-03	2.379	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	4.007656e-03	2.397	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	4.177110e-03	2.379	0	0
G2/M Checkpoints	R-HSA-69481	4.541058e-03	2.343	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	4.550992e-03	2.342	0	0
Nervous system development	R-HSA-9675108	4.924225e-03	2.308	1	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	5.264184e-03	2.279	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	5.264184e-03	2.279	0	0
Cleavage of the damaged purine	R-HSA-110331	5.478176e-03	2.261	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	5.530361e-03	2.257	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	6.061211e-03	2.217	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	5.797681e-03	2.237	0	0
Depyrimidination	R-HSA-73928	5.797681e-03	2.237	0	0
Homology Directed Repair	R-HSA-5693538	6.148101e-03	2.211	0	0
Oncogenic MAPK signaling	R-HSA-6802957	6.187968e-03	2.208	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	6.246921e-03	2.204	0	0
DCC mediated attractive signaling	R-HSA-418885	6.814545e-03	2.167	0	0
Regulation of endogenous retroelements	R-HSA-9842860	6.630613e-03	2.178	0	0
Defective pyroptosis	R-HSA-9710421	6.777603e-03	2.169	0	0
Depurination	R-HSA-73927	6.486420e-03	2.188	0	0
Rap1 signalling	R-HSA-392517	7.052928e-03	2.152	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	7.635719e-03	2.117	0	0
Netrin-1 signaling	R-HSA-373752	7.884472e-03	2.103	0	0
Activation of RAC1	R-HSA-428540	8.148326e-03	2.089	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	8.872175e-03	2.052	0	0
Type I hemidesmosome assembly	R-HSA-446107	9.178922e-03	2.037	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	9.285149e-03	2.032	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	9.460044e-03	2.024	0	0
Sema4D in semaphorin signaling	R-HSA-400685	1.032540e-02	1.986	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.007716e-02	1.997	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	1.032854e-02	1.986	0	0
Glycolysis	R-HSA-70171	1.032854e-02	1.986	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	1.134022e-02	1.945	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	1.134022e-02	1.945	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.127031e-02	1.948	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.127031e-02	1.948	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	1.089121e-02	1.963	0	0
Intracellular signaling by second messengers	R-HSA-9006925	1.064191e-02	1.973	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.092650e-02	1.962	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	1.069369e-02	1.971	0	0
Apoptotic execution phase	R-HSA-75153	1.052250e-02	1.978	0	0
snRNP Assembly	R-HSA-191859	1.165727e-02	1.933	0	0
Metabolism of non-coding RNA	R-HSA-194441	1.165727e-02	1.933	0	0
TRP channels	R-HSA-3295583	1.245906e-02	1.905	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	1.431553e-02	1.844	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	1.377537e-02	1.861	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.333122e-02	1.875	0	0
MTOR signalling	R-HSA-165159	1.390322e-02	1.857	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	1.377537e-02	1.861	0	0
PIP3 activates AKT signaling	R-HSA-1257604	1.393845e-02	1.856	0	0
Specification of primordial germ cells	R-HSA-9827857	1.427741e-02	1.845	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.566248e-02	1.805	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	1.566248e-02	1.805	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.673873e-02	1.776	0	0
Generic Transcription Pathway	R-HSA-212436	1.719810e-02	1.765	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	1.822617e-02	1.739	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.828361e-02	1.738	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.841725e-02	1.735	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	1.852917e-02	1.732	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	2.018542e-02	1.695	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	1.959394e-02	1.708	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	2.113191e-02	1.675	0	0
Nuclear import of Rev protein	R-HSA-180746	2.121366e-02	1.673	0	0
Gene Silencing by RNA	R-HSA-211000	2.082105e-02	1.681	0	0
RNA Polymerase I Transcription	R-HSA-73864	2.253827e-02	1.647	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	2.264385e-02	1.645	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	2.295578e-02	1.639	0	0
Cell-extracellular matrix interactions	R-HSA-446353	2.315714e-02	1.635	0	0
Meiosis	R-HSA-1500620	2.319317e-02	1.635	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	2.368972e-02	1.625	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	2.435213e-02	1.613	0	0
Amplification of signal from the kinetochores	R-HSA-141424	2.538391e-02	1.595	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.538391e-02	1.595	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.866698e-02	1.543	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.871074e-02	1.542	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	2.628288e-02	1.580	0	0
Epigenetic regulation of gene expression	R-HSA-212165	2.599696e-02	1.585	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	2.717359e-02	1.566	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	2.772740e-02	1.557	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.871074e-02	1.542	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	2.838884e-02	1.547	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	2.905494e-02	1.537	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	3.008177e-02	1.522	0	0
Assembly of the pre-replicative complex	R-HSA-68867	3.054635e-02	1.515	0	0
Glucose metabolism	R-HSA-70326	3.057750e-02	1.515	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	3.203806e-02	1.494	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	3.211845e-02	1.493	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	3.211845e-02	1.493	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	3.211845e-02	1.493	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	3.211845e-02	1.493	0	0
Dopamine receptors	R-HSA-390651	3.211845e-02	1.493	0	0
Reproduction	R-HSA-1474165	3.220703e-02	1.492	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	3.257377e-02	1.487	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	3.847575e-02	1.415	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	3.847575e-02	1.415	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	3.847575e-02	1.415	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	3.787018e-02	1.422	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	3.787018e-02	1.422	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	3.847575e-02	1.415	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.847575e-02	1.415	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.847575e-02	1.415	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	3.637990e-02	1.439	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.889935e-02	1.410	0	0
Meiotic recombination	R-HSA-912446	4.138132e-02	1.383	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.191478e-02	1.378	0	0
HIV elongation arrest and recovery	R-HSA-167287	4.371469e-02	1.359	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	4.371469e-02	1.359	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	4.661900e-02	1.331	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.698952e-02	1.328	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	4.698952e-02	1.328	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.698952e-02	1.328	0	0
WNT mediated activation of DVL	R-HSA-201688	4.997554e-02	1.301	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	4.997554e-02	1.301	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	4.380468e-02	1.358	0	0
RAF activation	R-HSA-5673000	4.841553e-02	1.315	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	4.884305e-02	1.311	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	4.884305e-02	1.311	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	4.884305e-02	1.311	0	0
Telomere Maintenance	R-HSA-157579	4.511468e-02	1.346	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	4.698952e-02	1.328	0	0
Signaling by RAS mutants	R-HSA-6802949	4.884305e-02	1.311	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	4.997554e-02	1.301	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.807342e-02	1.318	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	4.807342e-02	1.318	0	0
Neurexins and neuroligins	R-HSA-6794361	4.586498e-02	1.339	0	0
mTORC1-mediated signalling	R-HSA-166208	4.380468e-02	1.358	0	0
Signaling by WNT	R-HSA-195721	4.650991e-02	1.332	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.586498e-02	1.339	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	4.625192e-02	1.335	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	5.035763e-02	1.298	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	5.180644e-02	1.286	0	0
Kinesins	R-HSA-983189	5.190436e-02	1.285	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	5.190436e-02	1.285	0	0
Cell junction organization	R-HSA-446728	5.319975e-02	1.274	0	0
Signaling by ROBO receptors	R-HSA-376176	5.495604e-02	1.260	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	5.717864e-02	1.243	0	0
ISG15 antiviral mechanism	R-HSA-1169408	5.756620e-02	1.240	0	0
Signaling by RAF1 mutants	R-HSA-9656223	5.778687e-02	1.238	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	5.778687e-02	1.238	0	0
Deadenylation of mRNA	R-HSA-429947	5.888596e-02	1.230	0	0
Neurodegenerative Diseases	R-HSA-8863678	5.888596e-02	1.230	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	5.888596e-02	1.230	0	0
Regulation of TP53 Degradation	R-HSA-6804757	6.134445e-02	1.212	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	6.315492e-02	1.200	0	0
Chromosome Maintenance	R-HSA-73886	6.436076e-02	1.191	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	6.465764e-02	1.189	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	6.465764e-02	1.189	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	6.465764e-02	1.189	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.465764e-02	1.189	0	0
Trafficking of AMPA receptors	R-HSA-399719	6.468612e-02	1.189	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	7.702248e-02	1.113	0	0
RUNX3 regulates RUNX1-mediated transcription	R-HSA-8951911	7.702248e-02	1.113	0	0
Potassium transport channels	R-HSA-1296067	7.702248e-02	1.113	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	6.856117e-02	1.164	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	6.716159e-02	1.173	0	0
HDMs demethylate histones	R-HSA-3214842	6.748931e-02	1.171	0	0
DNA Replication Pre-Initiation	R-HSA-69002	6.716159e-02	1.173	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	6.994996e-02	1.155	0	0
Semaphorin interactions	R-HSA-373755	6.760745e-02	1.170	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	6.672796e-02	1.176	1	0
Cell-Cell communication	R-HSA-1500931	6.952183e-02	1.158	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	7.797141e-02	1.108	0	0
Phosphorylation of the APC/C	R-HSA-176412	8.105795e-02	1.091	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.105795e-02	1.091	0	0
EPH-Ephrin signaling	R-HSA-2682334	8.116014e-02	1.091	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	8.162182e-02	1.088	1	1
Cardiogenesis	R-HSA-9733709	8.162182e-02	1.088	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	8.162182e-02	1.088	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	8.162182e-02	1.088	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	8.452442e-02	1.073	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	8.452442e-02	1.073	0	0
CREB phosphorylation	R-HSA-199920	8.491048e-02	1.071	1	1
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	8.491048e-02	1.071	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	8.491048e-02	1.071	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	8.610078e-02	1.065	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.684042e-02	1.061	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	8.684042e-02	1.061	0	0
Ca2+ activated K+ channels	R-HSA-1296052	1.074886e-01	0.969	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	1.074886e-01	0.969	0	0
SOS-mediated signalling	R-HSA-112412	1.074886e-01	0.969	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	1.074886e-01	0.969	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	9.435595e-02	1.025	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	9.150495e-02	1.039	0	0
HIV Transcription Elongation	R-HSA-167169	9.327341e-02	1.030	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	9.327341e-02	1.030	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	9.327341e-02	1.030	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	1.075951e-01	0.968	0	0
Mitotic Prometaphase	R-HSA-68877	9.974875e-02	1.001	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	8.979397e-02	1.047	1	0
Regulation of PTEN localization	R-HSA-8948747	1.074886e-01	0.969	0	0
Protein ubiquitination	R-HSA-8852135	9.843451e-02	1.007	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	1.039764e-01	0.983	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	9.150495e-02	1.039	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	9.470320e-02	1.024	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	9.429424e-02	1.026	0	0
Drug resistance of PDGFR mutants	R-HSA-9674415	1.076487e-01	0.968	0	0
PDGFR mutants bind TKIs	R-HSA-9674428	1.076487e-01	0.968	0	0
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.076487e-01	0.968	0	0
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.076487e-01	0.968	0	0
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.076487e-01	0.968	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.076487e-01	0.968	0	0
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.076487e-01	0.968	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	1.094371e-01	0.961	0	0
tRNA processing in the nucleus	R-HSA-6784531	1.094725e-01	0.961	0	0
Heme signaling	R-HSA-9707616	1.094725e-01	0.961	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.101177e-01	0.958	0	0
NGF-stimulated transcription	R-HSA-9031628	1.120160e-01	0.951	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.122173e-01	0.950	0	0
MAP2K and MAPK activation	R-HSA-5674135	1.122931e-01	0.950	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	1.122931e-01	0.950	0	0
Ub-specific processing proteases	R-HSA-5689880	1.152627e-01	0.938	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.153898e-01	0.938	0	0
Protein-protein interactions at synapses	R-HSA-6794362	1.173135e-01	0.931	0	0
Ion homeostasis	R-HSA-5578775	1.198728e-01	0.921	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	1.211307e-01	0.917	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.037147e-01	0.691	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.037147e-01	0.691	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	2.037147e-01	0.691	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.037147e-01	0.691	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.037147e-01	0.691	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	2.037147e-01	0.691	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.037147e-01	0.691	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.037147e-01	0.691	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.500184e-01	0.824	0	0
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	1.500184e-01	0.824	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	1.500184e-01	0.824	0	0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	1.500184e-01	0.824	0	0
PI and PC transport between ER and Golgi membranes	R-HSA-1483196	2.894438e-01	0.538	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.894438e-01	0.538	0	0
Intestinal infectious diseases	R-HSA-8942233	2.894438e-01	0.538	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	2.894438e-01	0.538	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.894438e-01	0.538	0	0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	2.894438e-01	0.538	0	0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	R-HSA-6791055	2.894438e-01	0.538	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.894438e-01	0.538	0	0
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	R-HSA-5619111	2.894438e-01	0.538	0	0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	R-HSA-6791462	2.894438e-01	0.538	0	0
IRS activation	R-HSA-74713	1.902012e-01	0.721	0	0
PTK6 Down-Regulation	R-HSA-8849472	1.902012e-01	0.721	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.902012e-01	0.721	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	1.321046e-01	0.879	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.584577e-01	0.800	0	0
Lipophagy	R-HSA-9613354	1.584577e-01	0.800	0	0
PKA-mediated phosphorylation of key metabolic factors	R-HSA-163358	2.315862e-01	0.635	0	0
Phosphorylation of Emi1	R-HSA-176417	2.315862e-01	0.635	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	2.315862e-01	0.635	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.315862e-01	0.635	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	2.315862e-01	0.635	0	0
Signaling by MAPK mutants	R-HSA-9652817	2.315862e-01	0.635	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	3.659477e-01	0.437	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	3.659477e-01	0.437	0	0
Glycogen storage disease type 0 (muscle GYS1)	R-HSA-3828062	3.659477e-01	0.437	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	3.659477e-01	0.437	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	3.659477e-01	0.437	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	3.659477e-01	0.437	0	0
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	R-HSA-5655799	3.659477e-01	0.437	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	3.659477e-01	0.437	0	0
TWIK related potassium channel (TREK)	R-HSA-1299503	3.659477e-01	0.437	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	3.659477e-01	0.437	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	3.659477e-01	0.437	0	0
Mitotic Metaphase/Anaphase Transition	R-HSA-68881	3.659477e-01	0.437	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.659477e-01	0.437	0	0
Glycogen storage disease type XV (GYG1)	R-HSA-3814836	3.659477e-01	0.437	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	3.659477e-01	0.437	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	3.659477e-01	0.437	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	3.659477e-01	0.437	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	3.659477e-01	0.437	0	0
Formation of apoptosome	R-HSA-111458	1.862454e-01	0.730	0	0
Regulation of the apoptosome activity	R-HSA-9627069	1.862454e-01	0.730	0	0
cGMP effects	R-HSA-418457	1.519213e-01	0.818	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	2.734494e-01	0.563	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	2.734494e-01	0.563	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	1.252093e-01	0.902	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	2.151719e-01	0.667	0	0
Signaling by APC mutants	R-HSA-4839744	2.151719e-01	0.667	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.151719e-01	0.667	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.151719e-01	0.667	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.151719e-01	0.667	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.735091e-01	0.761	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	1.735091e-01	0.761	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	1.735091e-01	0.761	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	1.419599e-01	0.848	0	0
Differentiation of T cells	R-HSA-9945266	1.960716e-01	0.708	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	1.960716e-01	0.708	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	1.960716e-01	0.708	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	2.449539e-01	0.611	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	2.449539e-01	0.611	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	2.449539e-01	0.611	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	3.152086e-01	0.501	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	3.152086e-01	0.501	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	3.152086e-01	0.501	0	0
PTK6 Expression	R-HSA-8849473	3.152086e-01	0.501	0	0
The NLRP1 inflammasome	R-HSA-844455	4.342186e-01	0.362	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.342186e-01	0.362	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	4.342186e-01	0.362	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	4.342186e-01	0.362	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.781185e-01	0.749	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.194671e-01	0.659	0	0
Downstream signal transduction	R-HSA-186763	1.339046e-01	0.873	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	2.753256e-01	0.560	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.753256e-01	0.560	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.753256e-01	0.560	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.753256e-01	0.560	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.753256e-01	0.560	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.753256e-01	0.560	0	0
RET signaling	R-HSA-8853659	1.225910e-01	0.912	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	1.225910e-01	0.912	0	0
Signaling by PDGFR in disease	R-HSA-9671555	1.973727e-01	0.705	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	1.973727e-01	0.705	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	1.473126e-01	0.832	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	3.564012e-01	0.448	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	3.564012e-01	0.448	0	0
Activation of RAS in B cells	R-HSA-1169092	3.564012e-01	0.448	0	0
Notch-HLH transcription pathway	R-HSA-350054	2.173006e-01	0.663	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	3.060411e-01	0.514	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	3.060411e-01	0.514	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	3.060411e-01	0.514	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	2.681905e-01	0.572	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	2.125467e-01	0.673	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.588349e-01	0.587	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	2.932413e-01	0.533	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	3.966654e-01	0.402	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	4.951421e-01	0.305	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	4.951421e-01	0.305	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	4.951421e-01	0.305	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.951421e-01	0.305	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	4.951421e-01	0.305	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	4.951421e-01	0.305	0	0
AURKA Activation by TPX2	R-HSA-8854518	1.447664e-01	0.839	0	0
EGFR downregulation	R-HSA-182971	2.489979e-01	0.604	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	2.802680e-01	0.552	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	2.802680e-01	0.552	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.406784e-01	0.852	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	3.185748e-01	0.497	0	0
Erythropoietin activates RAS	R-HSA-9027284	3.676292e-01	0.435	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	3.676292e-01	0.435	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	3.676292e-01	0.435	0	0
Centrosome maturation	R-HSA-380287	1.590787e-01	0.798	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.923447e-01	0.716	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.923447e-01	0.716	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	3.440661e-01	0.463	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	4.357239e-01	0.361	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	4.357239e-01	0.361	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	4.357239e-01	0.361	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	3.240383e-01	0.489	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	3.695978e-01	0.432	0	0
Telomere Extension By Telomerase	R-HSA-171319	3.462098e-01	0.461	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	3.462098e-01	0.461	0	0
Formation of the Early Elongation Complex	R-HSA-113418	3.462098e-01	0.461	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	3.262031e-01	0.487	0	0
Signaling by Erythropoietin	R-HSA-9006335	3.684667e-01	0.434	0	0
Late endosomal microautophagy	R-HSA-9615710	3.684667e-01	0.434	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	3.684667e-01	0.434	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	3.950608e-01	0.403	0	0
Phase 2 - plateau phase	R-HSA-5576893	4.281955e-01	0.368	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	4.733695e-01	0.325	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.495085e-01	0.260	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.495085e-01	0.260	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	5.495085e-01	0.260	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	5.495085e-01	0.260	0	0
Defective binding of VWF variant to GPIb:IX:V	R-HSA-9846298	5.495085e-01	0.260	0	0
Defective F9 activation	R-HSA-9673221	5.495085e-01	0.260	0	0
Enhanced binding of GP1BA variant to VWF multimer:collagen	R-HSA-9845620	5.495085e-01	0.260	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	5.495085e-01	0.260	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	3.446957e-01	0.463	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	2.797699e-01	0.553	0	0
Interleukin receptor SHC signaling	R-HSA-912526	4.203544e-01	0.376	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	4.577163e-01	0.339	0	0
HSF1-dependent transactivation	R-HSA-3371571	3.595116e-01	0.444	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.094538e-01	0.293	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	5.094538e-01	0.293	0	0
ERKs are inactivated	R-HSA-202670	5.094538e-01	0.293	0	0
Transcription of the HIV genome	R-HSA-167172	3.672329e-01	0.435	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	3.934342e-01	0.405	0	0
Ephrin signaling	R-HSA-3928664	4.865683e-01	0.313	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	4.865683e-01	0.313	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	4.178415e-01	0.379	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	3.424782e-01	0.465	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	3.424782e-01	0.465	0	0
Tight junction interactions	R-HSA-420029	4.700755e-01	0.328	0	0
HCMV Early Events	R-HSA-9609690	3.310784e-01	0.480	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	4.785602e-01	0.320	0	0
Striated Muscle Contraction	R-HSA-390522	4.785602e-01	0.320	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	4.785602e-01	0.320	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	4.943463e-01	0.306	0	0
Regulation of signaling by CBL	R-HSA-912631	5.146553e-01	0.288	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	5.146553e-01	0.288	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	5.146553e-01	0.288	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	5.146553e-01	0.288	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	5.438766e-01	0.264	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	5.438766e-01	0.264	0	0
Polymerase switching	R-HSA-69091	5.438766e-01	0.264	0	0
Leading Strand Synthesis	R-HSA-69109	5.438766e-01	0.264	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.980232e-01	0.223	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	5.980232e-01	0.223	0	0
PKB-mediated events	R-HSA-109703	5.980232e-01	0.223	0	0
PDE3B signalling	R-HSA-165160	5.980232e-01	0.223	0	0
Signaling by RNF43 mutants	R-HSA-5340588	5.980232e-01	0.223	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.980232e-01	0.223	0	0
Defective CSF2RB causes SMDP5	R-HSA-5688849	5.980232e-01	0.223	0	0
Defective CSF2RA causes SMDP4	R-HSA-5688890	5.980232e-01	0.223	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	4.264211e-01	0.370	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	5.181342e-01	0.286	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	5.181342e-01	0.286	0	0
Co-inhibition by CTLA4	R-HSA-389513	5.418983e-01	0.266	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	5.418983e-01	0.266	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	5.418983e-01	0.266	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	5.418983e-01	0.266	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	5.418983e-01	0.266	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	4.807516e-01	0.318	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	5.413823e-01	0.266	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	5.765772e-01	0.239	0	0
Formation of axial mesoderm	R-HSA-9796292	5.765772e-01	0.239	0	0
Translation initiation complex formation	R-HSA-72649	5.596836e-01	0.252	0	0
DAP12 signaling	R-HSA-2424491	5.860729e-01	0.232	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.936156e-01	0.226	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	6.075274e-01	0.216	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	6.075274e-01	0.216	0	0
Removal of the Flap Intermediate	R-HSA-69166	6.075274e-01	0.216	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	6.075274e-01	0.216	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	5.960794e-01	0.225	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	6.086587e-01	0.216	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	6.086587e-01	0.216	0	0
Cellular response to heat stress	R-HSA-3371556	2.071667e-01	0.684	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	5.814511e-01	0.235	0	0
RNA Polymerase III Transcription	R-HSA-74158	1.225910e-01	0.912	0	0
Integrin signaling	R-HSA-354192	1.613261e-01	0.792	0	0
Regulation of necroptotic cell death	R-HSA-5675482	4.569137e-01	0.340	0	0
Recycling pathway of L1	R-HSA-437239	2.929225e-01	0.533	1	1
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	5.228494e-01	0.282	0	0
Regulation of mitotic cell cycle	R-HSA-453276	5.443352e-01	0.264	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	5.443352e-01	0.264	0	0
EPHB-mediated forward signaling	R-HSA-3928662	1.445136e-01	0.840	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	2.305434e-01	0.637	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	1.458121e-01	0.836	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	2.378169e-01	0.624	0	0
RUNX2 regulates bone development	R-HSA-8941326	5.415284e-01	0.266	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	5.418983e-01	0.266	0	0
Circadian clock	R-HSA-9909396	4.220491e-01	0.375	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	1.252093e-01	0.902	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	2.523480e-01	0.598	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	2.523480e-01	0.598	0	0
GP1b-IX-V activation signalling	R-HSA-430116	1.584577e-01	0.800	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	2.194671e-01	0.659	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.753256e-01	0.560	0	0
G0 and Early G1	R-HSA-1538133	1.473126e-01	0.832	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.660678e-01	0.780	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	2.608079e-01	0.584	0	0
Activation of the pre-replicative complex	R-HSA-68962	5.860729e-01	0.232	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	2.523480e-01	0.598	0	0
TGFBR3 expression	R-HSA-9839394	4.700755e-01	0.328	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	4.272951e-01	0.369	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	5.413823e-01	0.266	0	0
Polo-like kinase mediated events	R-HSA-156711	1.252093e-01	0.902	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	3.440661e-01	0.463	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	5.495085e-01	0.260	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	2.247694e-01	0.648	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	5.418983e-01	0.266	0	0
Signaling by PTK6	R-HSA-8848021	4.195262e-01	0.377	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	4.195262e-01	0.377	0	0
Frs2-mediated activation	R-HSA-170968	1.314466e-01	0.881	0	0
MHC class II antigen presentation	R-HSA-2132295	5.953538e-01	0.225	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	2.074581e-01	0.683	0	0
MET promotes cell motility	R-HSA-8875878	5.814511e-01	0.235	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	3.112407e-01	0.507	1	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	2.802680e-01	0.552	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	1.902012e-01	0.721	0	0
Formation of lateral plate mesoderm	R-HSA-9758920	2.315862e-01	0.635	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	1.862454e-01	0.730	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	3.152086e-01	0.501	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	3.564012e-01	0.448	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	2.173006e-01	0.663	0	0
Processing of SMDT1	R-HSA-8949664	3.060411e-01	0.514	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	3.966654e-01	0.402	0	0
PI3K/AKT activation	R-HSA-198203	4.357239e-01	0.361	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	3.262031e-01	0.487	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	3.086321e-01	0.511	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	4.577163e-01	0.339	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	4.577163e-01	0.339	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	4.423150e-01	0.354	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	3.446957e-01	0.463	0	0
Myogenesis	R-HSA-525793	3.020305e-01	0.520	0	0
Apoptotic factor-mediated response	R-HSA-111471	4.865683e-01	0.313	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	3.259165e-01	0.487	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	4.999089e-01	0.301	0	0
FOXO-mediated transcription	R-HSA-9614085	1.317178e-01	0.880	0	0
Signaling by PDGF	R-HSA-186797	5.434806e-01	0.265	0	0
Formation of definitive endoderm	R-HSA-9823730	1.596211e-01	0.797	0	0
Resolution of D-Loop Structures	R-HSA-5693537	4.785602e-01	0.320	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	1.500184e-01	0.824	0	0
Adrenoceptors	R-HSA-390696	1.321046e-01	0.879	0	0
Sodium/Proton exchangers	R-HSA-425986	1.321046e-01	0.879	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	1.584577e-01	0.800	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	2.315862e-01	0.635	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	2.753256e-01	0.560	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	3.564012e-01	0.448	0	0
Regulation of gap junction activity	R-HSA-191650	4.951421e-01	0.305	0	0
DARPP-32 events	R-HSA-180024	3.684667e-01	0.434	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	5.495085e-01	0.260	0	0
Separation of Sister Chromatids	R-HSA-2467813	2.627633e-01	0.580	0	0
PKA activation	R-HSA-163615	4.865683e-01	0.313	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	3.972168e-01	0.401	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	4.569137e-01	0.340	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	5.438766e-01	0.264	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	5.438766e-01	0.264	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	5.001512e-01	0.301	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	5.273861e-01	0.278	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	1.300412e-01	0.886	0	0
Post NMDA receptor activation events	R-HSA-438064	1.405148e-01	0.852	1	0
Nuclear RNA decay	R-HSA-9930044	2.870427e-01	0.542	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	1.923447e-01	0.716	0	0
S Phase	R-HSA-69242	1.994827e-01	0.700	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.618772e-01	0.791	0	0
Signal attenuation	R-HSA-74749	1.862454e-01	0.730	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	1.613261e-01	0.792	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	3.684667e-01	0.434	0	0
Long-term potentiation	R-HSA-9620244	4.700755e-01	0.328	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	5.438766e-01	0.264	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	4.999089e-01	0.301	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	4.828209e-01	0.316	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	2.245091e-01	0.649	0	0
Intra-Golgi traffic	R-HSA-6811438	4.850106e-01	0.314	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	1.433434e-01	0.844	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	3.764487e-01	0.424	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	5.936156e-01	0.226	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	4.812783e-01	0.318	1	0
TNF signaling	R-HSA-75893	4.443607e-01	0.352	0	0
Mitotic Anaphase	R-HSA-68882	1.382349e-01	0.859	0	0
Prolonged ERK activation events	R-HSA-169893	1.960716e-01	0.708	0	0
Co-stimulation by CD28	R-HSA-389356	1.938074e-01	0.713	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.565709e-01	0.805	0	0
Calcineurin activates NFAT	R-HSA-2025928	1.584577e-01	0.800	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.315862e-01	0.635	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.314466e-01	0.881	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	1.519213e-01	0.818	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	2.435535e-01	0.613	0	0
Activation of ATR in response to replication stress	R-HSA-176187	2.870427e-01	0.542	0	0
Killing mechanisms	R-HSA-9664420	3.981213e-01	0.400	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	3.981213e-01	0.400	0	0
Formation of the posterior neural plate	R-HSA-9832991	4.733695e-01	0.325	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.495085e-01	0.260	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	5.094538e-01	0.293	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	1.879145e-01	0.726	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	3.717821e-01	0.430	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	3.717821e-01	0.430	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	3.717821e-01	0.430	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	3.717821e-01	0.430	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	4.569137e-01	0.340	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	5.042887e-01	0.297	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	5.452294e-01	0.263	0	0
IRS-mediated signalling	R-HSA-112399	6.088474e-01	0.215	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	1.462649e-01	0.835	0	0
Calmodulin induced events	R-HSA-111933	2.227547e-01	0.652	0	0
Cyclin D associated events in G1	R-HSA-69231	5.420154e-01	0.266	0	0
G1 Phase	R-HSA-69236	5.420154e-01	0.266	0	0
IGF1R signaling cascade	R-HSA-2428924	5.749848e-01	0.240	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.588349e-01	0.587	0	0
Signaling by FGFR in disease	R-HSA-1226099	3.346902e-01	0.475	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	2.767379e-01	0.558	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	5.012947e-01	0.300	0	0
Interleukin-2 signaling	R-HSA-9020558	4.733695e-01	0.325	0	0
Glycogen metabolism	R-HSA-8982491	4.458064e-01	0.351	0	0
CaM pathway	R-HSA-111997	2.227547e-01	0.652	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	5.094538e-01	0.293	0	0
PLC beta mediated events	R-HSA-112043	3.876718e-01	0.412	0	0
Cilium Assembly	R-HSA-5617833	5.938214e-01	0.226	0	0
Signaling by SCF-KIT	R-HSA-1433557	3.629181e-01	0.440	0	0
DAG and IP3 signaling	R-HSA-1489509	2.608079e-01	0.584	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	1.500184e-01	0.824	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.315862e-01	0.635	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	1.613261e-01	0.792	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	4.357239e-01	0.361	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	3.695978e-01	0.432	0	0
Signaling by EGFR	R-HSA-177929	3.091089e-01	0.510	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	4.060152e-01	0.391	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	4.943463e-01	0.306	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	5.980232e-01	0.223	0	0
Switching of origins to a post-replicative state	R-HSA-69052	5.740276e-01	0.241	0	0
Signaling by VEGF	R-HSA-194138	1.277926e-01	0.893	0	0
PTEN Regulation	R-HSA-6807070	6.048849e-01	0.218	0	0
DNA Replication	R-HSA-69306	3.119416e-01	0.506	0	0
Mismatch Repair	R-HSA-5358508	4.865683e-01	0.313	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	4.130901e-01	0.384	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	5.903579e-01	0.229	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	2.449539e-01	0.611	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	3.086321e-01	0.511	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	3.460541e-01	0.461	0	0
Repression of WNT target genes	R-HSA-4641265	5.438766e-01	0.264	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	5.413823e-01	0.266	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	5.640422e-01	0.249	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.319353e-01	0.880	1	0
Signalling to ERKs	R-HSA-187687	3.460541e-01	0.461	0	0
HIV Infection	R-HSA-162906	3.175926e-01	0.498	0	0
Co-inhibition by PD-1	R-HSA-389948	5.225233e-01	0.282	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	3.152086e-01	0.501	0	0
Host Interactions of HIV factors	R-HSA-162909	1.675744e-01	0.776	0	0
PTK6 Activates STAT3	R-HSA-8849474	5.495085e-01	0.260	0	0
Ca-dependent events	R-HSA-111996	3.446957e-01	0.463	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	3.907341e-01	0.408	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	5.094538e-01	0.293	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.421072e-01	0.466	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.203544e-01	0.376	0	0
Cardiac conduction	R-HSA-5576891	2.422073e-01	0.616	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	4.453869e-01	0.351	0	0
G1/S Transition	R-HSA-69206	5.281854e-01	0.277	0	0
HIV Life Cycle	R-HSA-162587	2.068087e-01	0.684	0	0
Signaling by NOTCH1	R-HSA-1980143	3.628086e-01	0.440	0	0
Developmental Biology	R-HSA-1266738	3.748690e-01	0.426	1	0
RAF/MAP kinase cascade	R-HSA-5673001	1.421178e-01	0.847	0	0
Muscle contraction	R-HSA-397014	4.046567e-01	0.393	0	0
Membrane Trafficking	R-HSA-199991	5.717808e-01	0.243	0	0
Autophagy	R-HSA-9612973	4.245815e-01	0.372	0	0
Signaling by NOTCH	R-HSA-157118	4.962971e-01	0.304	0	0
G2/M Transition	R-HSA-69275	2.495285e-01	0.603	0	0
Metabolism of RNA	R-HSA-8953854	1.268157e-01	0.897	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.894438e-01	0.538	0	0
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	1.902012e-01	0.721	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	3.659477e-01	0.437	0	0
Bicarbonate transporters	R-HSA-425381	2.151719e-01	0.667	0	0
Signaling by AXIN mutants	R-HSA-4839735	2.449539e-01	0.611	0	0
Signaling by AMER1 mutants	R-HSA-4839748	2.449539e-01	0.611	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	3.152086e-01	0.501	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	4.342186e-01	0.362	0	0
MET interacts with TNS proteins	R-HSA-8875513	4.342186e-01	0.362	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	2.194671e-01	0.659	0	0
Signaling by LTK	R-HSA-9842663	2.753256e-01	0.560	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	3.060411e-01	0.514	0	0
Unwinding of DNA	R-HSA-176974	3.966654e-01	0.402	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	1.698846e-01	0.770	0	0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	R-HSA-2151209	4.357239e-01	0.361	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	3.981213e-01	0.400	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	3.695978e-01	0.432	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	4.733695e-01	0.325	0	0
Trafficking of myristoylated proteins to the cilium	R-HSA-5624138	5.495085e-01	0.260	0	0
Reelin signalling pathway	R-HSA-8866376	5.495085e-01	0.260	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.017954e-01	0.520	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	3.559533e-01	0.449	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	4.453869e-01	0.351	0	0
Mitotic G2-G2/M phases	R-HSA-453274	2.651473e-01	0.577	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	4.865683e-01	0.313	0	0
PKA activation in glucagon signalling	R-HSA-164378	4.865683e-01	0.313	0	0
Pentose phosphate pathway disease	R-HSA-6791465	5.980232e-01	0.223	0	0
NGF-independant TRKA activation	R-HSA-187024	5.980232e-01	0.223	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	5.980232e-01	0.223	0	0
Synthesis of PS	R-HSA-1483101	5.980232e-01	0.223	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	5.980232e-01	0.223	0	0
Formation of the Editosome	R-HSA-75094	5.980232e-01	0.223	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	4.999089e-01	0.301	0	0
Negative regulation of MET activity	R-HSA-6807004	5.418983e-01	0.266	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	6.006959e-01	0.221	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	5.727715e-01	0.242	0	0
DNA Repair	R-HSA-73894	3.582413e-01	0.446	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	1.756230e-01	0.755	0	0
G-protein mediated events	R-HSA-112040	4.828209e-01	0.316	0	0
FLT3 signaling in disease	R-HSA-9682385	2.227547e-01	0.652	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.037956e-01	0.691	0	0
Generation of second messenger molecules	R-HSA-202433	4.458064e-01	0.351	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	4.943463e-01	0.306	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	6.075274e-01	0.216	0	0
FLT3 Signaling	R-HSA-9607240	1.861556e-01	0.730	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	3.656526e-01	0.437	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	1.809510e-01	0.742	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	4.197801e-01	0.377	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	5.146553e-01	0.288	1	1
Interleukin-2 family signaling	R-HSA-451927	4.458064e-01	0.351	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.684667e-01	0.434	1	0
Macroautophagy	R-HSA-1632852	5.313352e-01	0.275	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	2.608079e-01	0.584	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.589839e-01	0.799	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.589839e-01	0.799	0	0
Signaling by TGFBR3	R-HSA-9839373	5.784300e-01	0.238	0	0
MAPK family signaling cascades	R-HSA-5683057	1.474983e-01	0.831	0	0
Cellular responses to stress	R-HSA-2262752	3.769674e-01	0.424	1	0
Cell-cell junction organization	R-HSA-421270	3.731871e-01	0.428	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.973727e-01	0.705	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	4.281955e-01	0.368	0	0
TBC/RABGAPs	R-HSA-8854214	5.233013e-01	0.281	0	0
ERK/MAPK targets	R-HSA-198753	5.682345e-01	0.245	1	1
Intrinsic Pathway for Apoptosis	R-HSA-109606	5.927805e-01	0.227	0	0
Adherens junctions interactions	R-HSA-418990	3.826117e-01	0.417	0	0
Programmed Cell Death	R-HSA-5357801	3.443930e-01	0.463	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	4.865683e-01	0.313	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	5.765772e-01	0.239	0	0
Signaling by NTRKs	R-HSA-166520	1.446217e-01	0.840	1	0
Signaling by ERBB4	R-HSA-1236394	3.346902e-01	0.475	0	0
Cellular responses to stimuli	R-HSA-8953897	4.341239e-01	0.362	1	0
Interleukin-1 processing	R-HSA-448706	1.584577e-01	0.800	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	3.152086e-01	0.501	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	3.060411e-01	0.514	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	3.060411e-01	0.514	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	3.966654e-01	0.402	0	0
Syndecan interactions	R-HSA-3000170	4.203544e-01	0.376	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.980232e-01	0.223	0	0
Defects of platelet adhesion to exposed collagen	R-HSA-9823587	5.980232e-01	0.223	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	5.980232e-01	0.223	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	5.480089e-01	0.261	0	0
Inflammasomes	R-HSA-622312	3.462098e-01	0.461	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	3.345306e-01	0.476	0	0
The NLRP3 inflammasome	R-HSA-844456	2.932413e-01	0.533	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	3.717821e-01	0.430	0	0
Deubiquitination	R-HSA-5688426	3.382367e-01	0.471	0	0
Regulation of KIT signaling	R-HSA-1433559	3.368762e-01	0.473	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.966654e-01	0.402	0	0
Formation of the nephric duct	R-HSA-9830364	2.802680e-01	0.552	0	0
HCMV Late Events	R-HSA-9610379	3.499862e-01	0.456	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	2.681905e-01	0.572	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	5.035480e-01	0.298	0	0
L1CAM interactions	R-HSA-373760	5.146847e-01	0.288	1	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	5.209125e-01	0.283	0	0
Apoptosis	R-HSA-109581	3.180958e-01	0.497	0	0
Breakdown of the nuclear lamina	R-HSA-352238	2.894438e-01	0.538	0	0
DSCAM interactions	R-HSA-376172	3.659477e-01	0.437	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	1.862454e-01	0.730	0	0
Synthesis of PI	R-HSA-1483226	2.151719e-01	0.667	0	0
Formation of the anterior neural plate	R-HSA-9823739	1.735091e-01	0.761	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.342186e-01	0.362	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	2.194671e-01	0.659	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	1.781583e-01	0.749	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	2.681905e-01	0.572	0	0
ARMS-mediated activation	R-HSA-170984	3.966654e-01	0.402	0	0
Sensory perception of sour taste	R-HSA-9729555	4.951421e-01	0.305	0	0
Tandem pore domain potassium channels	R-HSA-1296346	4.357239e-01	0.361	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	4.733695e-01	0.325	0	0
Biosynthesis of DPAn-3-derived 13-series resolvins	R-HSA-9026403	5.495085e-01	0.260	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	5.980232e-01	0.223	0	0
Amine ligand-binding receptors	R-HSA-375280	5.420154e-01	0.266	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	4.667901e-01	0.331	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	3.543317e-01	0.451	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	3.086321e-01	0.511	0	0
Sensory processing of sound	R-HSA-9659379	4.054940e-01	0.392	0	0
Protein hydroxylation	R-HSA-9629569	5.418983e-01	0.266	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	4.350217e-01	0.361	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.862454e-01	0.730	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.734494e-01	0.563	0	0
G1/S-Specific Transcription	R-HSA-69205	2.227547e-01	0.652	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	2.870427e-01	0.542	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	2.867320e-01	0.543	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	3.672329e-01	0.435	0	0
Stimuli-sensing channels	R-HSA-2672351	2.152591e-01	0.667	0	0
Ion channel transport	R-HSA-983712	5.847304e-01	0.233	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	5.848317e-01	0.233	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	4.584538e-01	0.339	0	0
Signaling by ALK in cancer	R-HSA-9700206	2.867320e-01	0.543	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.254355e-01	0.279	0	0
Diseases of DNA repair	R-HSA-9675135	5.784300e-01	0.238	0	0
Activation of BH3-only proteins	R-HSA-114452	5.860729e-01	0.232	0	0
PI Metabolism	R-HSA-1483255	4.125908e-01	0.384	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	3.091089e-01	0.510	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	3.406272e-01	0.468	0	0
NrCAM interactions	R-HSA-447038	1.902012e-01	0.721	0	0
Sodium-coupled phosphate cotransporters	R-HSA-427652	2.315862e-01	0.635	0	0
MECP2 regulates transcription factors	R-HSA-9022707	3.152086e-01	0.501	0	0
Phase 3 - rapid repolarisation	R-HSA-5576890	3.152086e-01	0.501	0	0
Interleukin-18 signaling	R-HSA-9012546	3.564012e-01	0.448	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	4.951421e-01	0.305	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	3.091089e-01	0.510	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	5.980232e-01	0.223	0	0
Acetylcholine inhibits contraction of outer hair cells	R-HSA-9667769	5.980232e-01	0.223	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	5.765772e-01	0.239	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	5.308935e-01	0.275	0	0
Amyloid fiber formation	R-HSA-977225	1.450778e-01	0.838	0	0
MITF-M-dependent gene expression	R-HSA-9856651	2.149677e-01	0.668	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	3.981213e-01	0.400	0	0
Interleukin-7 signaling	R-HSA-1266695	2.802680e-01	0.552	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.020305e-01	0.520	0	0
Nephrin family interactions	R-HSA-373753	5.418983e-01	0.266	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	3.368762e-01	0.473	0	0
Potential therapeutics for SARS	R-HSA-9679191	3.640519e-01	0.439	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	2.329946e-01	0.633	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	5.210875e-01	0.283	0	0
STING mediated induction of host immune responses	R-HSA-1834941	5.146553e-01	0.288	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	5.617190e-01	0.250	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.966654e-01	0.402	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	3.676292e-01	0.435	0	0
Toxicity of botulinum toxin type C (botC)	R-HSA-5250971	5.495085e-01	0.260	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.980232e-01	0.223	0	0
Inositol phosphate metabolism	R-HSA-1483249	4.426035e-01	0.354	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	4.195262e-01	0.377	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.681905e-01	0.572	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	4.454162e-01	0.351	0	0
Interleukin-15 signaling	R-HSA-8983432	5.438766e-01	0.264	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	5.682345e-01	0.245	0	0
Base Excision Repair	R-HSA-73884	2.442959e-01	0.612	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	5.814511e-01	0.235	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	5.839983e-01	0.234	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	4.513079e-01	0.346	0	0
Signaling by Leptin	R-HSA-2586552	4.357239e-01	0.361	0	0
Interleukin-37 signaling	R-HSA-9008059	2.305434e-01	0.637	0	0
Metal ion SLC transporters	R-HSA-425410	6.133276e-01	0.212	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	6.161773e-01	0.210	0	0
Interleukin-12 signaling	R-HSA-9020591	6.168731e-01	0.210	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	6.180065e-01	0.209	0	0
FGFR2 alternative splicing	R-HSA-6803529	6.180065e-01	0.209	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	6.180065e-01	0.209	0	0
Eukaryotic Translation Initiation	R-HSA-72613	6.187111e-01	0.209	0	0
Cap-dependent Translation Initiation	R-HSA-72737	6.187111e-01	0.209	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	6.194293e-01	0.208	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	6.194293e-01	0.208	0	0
Aggrephagy	R-HSA-9646399	6.194293e-01	0.208	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	6.194293e-01	0.208	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	6.245711e-01	0.204	0	0
DNA strand elongation	R-HSA-69190	6.281190e-01	0.202	0	0
Signaling by WNT in cancer	R-HSA-4791275	6.281190e-01	0.202	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	6.301564e-01	0.201	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	6.301564e-01	0.201	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	6.318313e-01	0.199	1	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	6.318313e-01	0.199	1	0
Regulated Necrosis	R-HSA-5218859	6.347741e-01	0.197	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	6.367250e-01	0.196	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	6.367250e-01	0.196	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	6.367250e-01	0.196	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	6.367250e-01	0.196	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	6.367250e-01	0.196	0	0
Processive synthesis on the lagging strand	R-HSA-69183	6.367250e-01	0.196	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	6.367250e-01	0.196	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	6.367250e-01	0.196	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	6.367250e-01	0.196	0	0
Spry regulation of FGF signaling	R-HSA-1295596	6.367250e-01	0.196	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	6.367250e-01	0.196	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	6.367250e-01	0.196	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	6.367250e-01	0.196	0	0
Signaling by Interleukins	R-HSA-449147	6.367837e-01	0.196	1	0
Extension of Telomeres	R-HSA-180786	6.399370e-01	0.194	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	6.402120e-01	0.194	0	0
Erythropoietin activates STAT5	R-HSA-9027283	6.413158e-01	0.193	0	0
STAT5 Activation	R-HSA-9645135	6.413158e-01	0.193	0	0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	R-HSA-629587	6.413158e-01	0.193	0	0
Autointegration results in viral DNA circles	R-HSA-177539	6.413158e-01	0.193	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	6.413158e-01	0.193	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	6.413158e-01	0.193	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	6.413158e-01	0.193	0	0
Abacavir transmembrane transport	R-HSA-2161517	6.413158e-01	0.193	0	0
NADPH regeneration	R-HSA-389542	6.413158e-01	0.193	0	0
Lipid particle organization	R-HSA-8964572	6.413158e-01	0.193	0	0
Nef and signal transduction	R-HSA-164944	6.413158e-01	0.193	0	0
Formation of the ureteric bud	R-HSA-9830674	6.413837e-01	0.193	0	0
Growth hormone receptor signaling	R-HSA-982772	6.413837e-01	0.193	0	0
Signaling by TGFB family members	R-HSA-9006936	6.423092e-01	0.192	0	0
PI3K Cascade	R-HSA-109704	6.465500e-01	0.189	0	0
G-protein beta:gamma signalling	R-HSA-397795	6.480870e-01	0.188	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	6.480870e-01	0.188	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	6.480870e-01	0.188	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	6.480870e-01	0.188	0	0
HCMV Infection	R-HSA-9609646	6.497326e-01	0.187	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	6.532776e-01	0.185	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	6.551245e-01	0.184	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	6.552844e-01	0.184	0	0
Opioid Signalling	R-HSA-111885	6.574124e-01	0.182	0	0
Influenza Infection	R-HSA-168255	6.576468e-01	0.182	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	6.628405e-01	0.179	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	6.641883e-01	0.178	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	6.641883e-01	0.178	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	6.641883e-01	0.178	0	0
Regulation of BACH1 activity	R-HSA-9708530	6.641883e-01	0.178	0	0
Negative regulation of FLT3	R-HSA-9706369	6.641883e-01	0.178	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	6.641883e-01	0.178	0	0
Serotonin and melatonin biosynthesis	R-HSA-209931	6.641883e-01	0.178	0	0
Integration of energy metabolism	R-HSA-163685	6.670888e-01	0.176	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	6.673301e-01	0.176	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	6.673301e-01	0.176	0	0
Signaling by MET	R-HSA-6806834	6.703272e-01	0.174	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	6.723770e-01	0.172	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.763805e-01	0.170	0	0
Adaptive Immune System	R-HSA-1280218	6.775568e-01	0.169	0	0
Developmental Cell Lineages	R-HSA-9734767	6.784060e-01	0.169	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	6.798192e-01	0.168	1	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	6.799481e-01	0.168	0	0
Netrin mediated repulsion signals	R-HSA-418886	6.799481e-01	0.168	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	6.799481e-01	0.168	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.799481e-01	0.168	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.799481e-01	0.168	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.799481e-01	0.168	0	0
mRNA Editing: C to U Conversion	R-HSA-72200	6.799481e-01	0.168	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	6.799481e-01	0.168	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	6.799481e-01	0.168	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.799481e-01	0.168	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	6.799481e-01	0.168	0	0
Activation of TRKA receptors	R-HSA-187015	6.799481e-01	0.168	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	6.799481e-01	0.168	0	0
CHL1 interactions	R-HSA-447041	6.799481e-01	0.168	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.799481e-01	0.168	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	6.837749e-01	0.165	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	6.850531e-01	0.164	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	6.850531e-01	0.164	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	6.850531e-01	0.164	0	0
Acyl chain remodelling of PS	R-HSA-1482801	6.850531e-01	0.164	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	6.858387e-01	0.164	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	6.858387e-01	0.164	0	0
Signaling by FGFR4	R-HSA-5654743	6.888995e-01	0.162	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	6.899523e-01	0.161	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	6.899523e-01	0.161	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	6.899523e-01	0.161	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	6.899523e-01	0.161	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	6.899523e-01	0.161	0	0
Disorders of Developmental Biology	R-HSA-9675151	6.899523e-01	0.161	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	6.899523e-01	0.161	0	0
Passive transport by Aquaporins	R-HSA-432047	6.899523e-01	0.161	0	0
Synthesis of PG	R-HSA-1483148	6.899523e-01	0.161	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	6.930395e-01	0.159	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	6.976053e-01	0.156	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	7.018362e-01	0.154	1	0
RMTs methylate histone arginines	R-HSA-3214858	7.048457e-01	0.152	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.053449e-01	0.152	0	0
Insulin receptor signalling cascade	R-HSA-74751	7.110344e-01	0.148	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	7.110344e-01	0.148	0	0
IRE1alpha activates chaperones	R-HSA-381070	7.122802e-01	0.147	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.140643e-01	0.146	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	7.140643e-01	0.146	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	7.140643e-01	0.146	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	7.140643e-01	0.146	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	7.140643e-01	0.146	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	7.140643e-01	0.146	0	0
RSK activation	R-HSA-444257	7.144214e-01	0.146	1	1
Highly calcium permeable nicotinic acetylcholine receptors	R-HSA-629597	7.144214e-01	0.146	0	0
Myoclonic epilepsy of Lafora	R-HSA-3785653	7.144214e-01	0.146	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	7.144214e-01	0.146	0	0
FGFR1b ligand binding and activation	R-HSA-190370	7.144214e-01	0.146	0	0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	R-HSA-8939242	7.144214e-01	0.146	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	7.144214e-01	0.146	0	0
Regulation by c-FLIP	R-HSA-3371378	7.144214e-01	0.146	0	0
Co-stimulation by ICOS	R-HSA-9927354	7.144214e-01	0.146	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	7.144214e-01	0.146	0	0
Dimerization of procaspase-8	R-HSA-69416	7.144214e-01	0.146	0	0
TGFBR3 PTM regulation	R-HSA-9839383	7.144214e-01	0.146	0	0
Alpha-defensins	R-HSA-1462054	7.144214e-01	0.146	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	7.144214e-01	0.146	0	0
Hedgehog 'off' state	R-HSA-5610787	7.171612e-01	0.144	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	7.202124e-01	0.143	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	7.202124e-01	0.143	0	0
Signaling by FGFR3	R-HSA-5654741	7.202124e-01	0.143	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	7.202124e-01	0.143	0	0
Glycosphingolipid transport	R-HSA-9845576	7.206385e-01	0.142	0	0
GPVI-mediated activation cascade	R-HSA-114604	7.206385e-01	0.142	0	0
Eukaryotic Translation Elongation	R-HSA-156842	7.233413e-01	0.141	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	7.246199e-01	0.140	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	7.246199e-01	0.140	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	7.246199e-01	0.140	0	0
Cristae formation	R-HSA-8949613	7.246199e-01	0.140	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	7.246199e-01	0.140	0	0
Rab regulation of trafficking	R-HSA-9007101	7.266971e-01	0.139	0	0
Mitochondrial biogenesis	R-HSA-1592230	7.266971e-01	0.139	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	7.317355e-01	0.136	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	7.349991e-01	0.134	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	7.349991e-01	0.134	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	7.349991e-01	0.134	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	7.352135e-01	0.134	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	7.365813e-01	0.133	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	7.365813e-01	0.133	0	0
Tie2 Signaling	R-HSA-210993	7.365813e-01	0.133	0	0
Platelet sensitization by LDL	R-HSA-432142	7.365813e-01	0.133	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	7.428940e-01	0.129	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	7.428940e-01	0.129	0	0
Pyroptosis	R-HSA-5620971	7.428940e-01	0.129	0	0
Interleukin-21 signaling	R-HSA-9020958	7.451834e-01	0.128	0	0
CASP8 activity is inhibited	R-HSA-5218900	7.451834e-01	0.128	0	0
ALK mutants bind TKIs	R-HSA-9700645	7.451834e-01	0.128	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.451834e-01	0.128	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	7.451834e-01	0.128	0	0
p75NTR regulates axonogenesis	R-HSA-193697	7.451834e-01	0.128	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	7.451834e-01	0.128	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	7.451834e-01	0.128	0	0
mRNA Editing	R-HSA-75072	7.451834e-01	0.128	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	7.451834e-01	0.128	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	7.451834e-01	0.128	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	7.451834e-01	0.128	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.451834e-01	0.128	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	7.451834e-01	0.128	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	7.451834e-01	0.128	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	7.454886e-01	0.128	0	0
Kidney development	R-HSA-9830369	7.488835e-01	0.126	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	7.492077e-01	0.125	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	7.523906e-01	0.124	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	7.564813e-01	0.121	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	7.575671e-01	0.121	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	7.575671e-01	0.121	0	0
Specification of the neural plate border	R-HSA-9834899	7.575671e-01	0.121	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	7.601884e-01	0.119	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	7.601884e-01	0.119	0	0
Platelet calcium homeostasis	R-HSA-418360	7.601884e-01	0.119	0	0
Interleukin-12 family signaling	R-HSA-447115	7.628597e-01	0.118	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	7.647575e-01	0.116	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	7.721610e-01	0.112	0	0
DNA replication initiation	R-HSA-68952	7.726334e-01	0.112	0	0
Folding of actin by CCT/TriC	R-HSA-390450	7.726334e-01	0.112	0	0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	R-HSA-629594	7.726334e-01	0.112	0	0
Regulation of CDH11 function	R-HSA-9762292	7.726334e-01	0.112	0	0
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	7.726334e-01	0.112	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	7.726334e-01	0.112	0	0
Formation of intermediate mesoderm	R-HSA-9761174	7.726334e-01	0.112	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	7.726334e-01	0.112	0	0
2-LTR circle formation	R-HSA-164843	7.726334e-01	0.112	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.726334e-01	0.112	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	7.726334e-01	0.112	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	7.726334e-01	0.112	0	0
Maturation of spike protein	R-HSA-9683686	7.726334e-01	0.112	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	7.726334e-01	0.112	0	0
Defective factor IX causes hemophilia B	R-HSA-9668250	7.726334e-01	0.112	0	0
Metal sequestration by antimicrobial proteins	R-HSA-6799990	7.726334e-01	0.112	0	0
Peptide chain elongation	R-HSA-156902	7.730126e-01	0.112	0	0
Selective autophagy	R-HSA-9663891	7.730126e-01	0.112	0	0
DNA Damage Bypass	R-HSA-73893	7.759091e-01	0.110	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	7.765280e-01	0.110	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	7.765280e-01	0.110	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	7.765280e-01	0.110	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	7.765280e-01	0.110	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	7.765280e-01	0.110	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	7.770901e-01	0.110	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.770901e-01	0.110	0	0
Attenuation phase	R-HSA-3371568	7.814854e-01	0.107	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	7.814854e-01	0.107	0	0
Diseases of Immune System	R-HSA-5260271	7.814854e-01	0.107	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.814854e-01	0.107	0	0
Signaling by FGFR2	R-HSA-5654738	7.825383e-01	0.106	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.830685e-01	0.106	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	7.832375e-01	0.106	0	0
Signaling by ERBB2	R-HSA-1227986	7.848212e-01	0.105	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	7.867505e-01	0.104	1	0
Regulation of RAS by GAPs	R-HSA-5658442	7.884158e-01	0.103	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	7.884158e-01	0.103	0	0
Budding and maturation of HIV virion	R-HSA-162588	7.919408e-01	0.101	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	7.919408e-01	0.101	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	7.925640e-01	0.101	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	7.928338e-01	0.101	1	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	7.928338e-01	0.101	1	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	7.928338e-01	0.101	1	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.936589e-01	0.100	0	0
Synthesis of DNA	R-HSA-69239	7.937683e-01	0.100	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	7.952219e-01	0.100	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	7.952219e-01	0.100	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	7.952219e-01	0.100	0	0
Lagging Strand Synthesis	R-HSA-69186	7.952219e-01	0.100	0	0
Signalling to RAS	R-HSA-167044	7.952219e-01	0.100	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	7.952219e-01	0.100	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	7.952219e-01	0.100	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	7.952219e-01	0.100	0	0
Basigin interactions	R-HSA-210991	7.952219e-01	0.100	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	7.952219e-01	0.100	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.960511e-01	0.099	0	0
MAP kinase activation	R-HSA-450294	7.960511e-01	0.099	1	0
Aquaporin-mediated transport	R-HSA-445717	7.960511e-01	0.099	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.971278e-01	0.098	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.971278e-01	0.098	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.971278e-01	0.098	0	0
FGFR2b ligand binding and activation	R-HSA-190377	7.971278e-01	0.098	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	7.971278e-01	0.098	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	7.971278e-01	0.098	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.971278e-01	0.098	0	0
Biosynthesis of DPAn-3-derived maresins	R-HSA-9026290	7.971278e-01	0.098	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.971278e-01	0.098	0	0
PECAM1 interactions	R-HSA-210990	7.971278e-01	0.098	0	0
Transport of RCbl within the body	R-HSA-9758890	7.971278e-01	0.098	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	8.015872e-01	0.096	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	8.021833e-01	0.096	1	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	8.077085e-01	0.093	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	8.077085e-01	0.093	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.077085e-01	0.093	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.092246e-01	0.092	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	8.103437e-01	0.091	1	0
Cytoprotection by HMOX1	R-HSA-9707564	8.115740e-01	0.091	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	8.117885e-01	0.091	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	8.120357e-01	0.090	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	8.120357e-01	0.090	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	8.120357e-01	0.090	0	0
Ca2+ pathway	R-HSA-4086398	8.136584e-01	0.090	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	8.183826e-01	0.087	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	8.189847e-01	0.087	0	0
Presynaptic nicotinic acetylcholine receptors	R-HSA-622323	8.189847e-01	0.087	0	0
Integration of provirus	R-HSA-162592	8.189847e-01	0.087	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	8.189847e-01	0.087	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	8.189847e-01	0.087	0	0
NF-kB is activated and signals survival	R-HSA-209560	8.189847e-01	0.087	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.189847e-01	0.087	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	8.189847e-01	0.087	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.189847e-01	0.087	0	0
Sodium/Calcium exchangers	R-HSA-425561	8.189847e-01	0.087	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	8.226772e-01	0.085	0	0
Amino acids regulate mTORC1	R-HSA-9639288	8.226772e-01	0.085	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.259360e-01	0.083	1	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.259360e-01	0.083	1	0
Ion transport by P-type ATPases	R-HSA-936837	8.270316e-01	0.082	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	8.273903e-01	0.082	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	8.276049e-01	0.082	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	8.276049e-01	0.082	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	8.276049e-01	0.082	0	0
Signaling by KIT in disease	R-HSA-9669938	8.276049e-01	0.082	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	8.276049e-01	0.082	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	8.276049e-01	0.082	0	0
PPARA activates gene expression	R-HSA-1989781	8.289976e-01	0.081	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	8.329341e-01	0.079	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	8.329341e-01	0.079	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	8.329341e-01	0.079	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	8.330511e-01	0.079	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	8.330511e-01	0.079	0	0
Neuronal System	R-HSA-112316	8.361032e-01	0.078	1	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	8.375531e-01	0.077	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	8.384879e-01	0.077	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	8.384879e-01	0.077	0	0
GRB2 events in EGFR signaling	R-HSA-179812	8.384879e-01	0.077	0	0
Scavenging by Class F Receptors	R-HSA-3000484	8.384879e-01	0.077	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	8.384879e-01	0.077	0	0
IRAK1 recruits IKK complex	R-HSA-937039	8.384879e-01	0.077	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	8.384879e-01	0.077	0	0
MET activates RAS signaling	R-HSA-8851805	8.384879e-01	0.077	0	0
VLDLR internalisation and degradation	R-HSA-8866427	8.384879e-01	0.077	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	8.384879e-01	0.077	0	0
Biosynthesis of DPAn-3-derived protectins and resolvins	R-HSA-9026286	8.384879e-01	0.077	0	0
Diseases associated with surfactant metabolism	R-HSA-5687613	8.384879e-01	0.077	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	8.384879e-01	0.077	0	0
Regulation of IFNG signaling	R-HSA-877312	8.384879e-01	0.077	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.384879e-01	0.077	0	0
Pervasive developmental disorders	R-HSA-9005895	8.384879e-01	0.077	0	0
Disorders of Nervous System Development	R-HSA-9697154	8.384879e-01	0.077	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	8.384879e-01	0.077	0	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.384879e-01	0.077	0	0
Estrogen biosynthesis	R-HSA-193144	8.384879e-01	0.077	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	8.384879e-01	0.077	0	0
OAS antiviral response	R-HSA-8983711	8.384879e-01	0.077	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	8.404884e-01	0.075	1	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	8.413099e-01	0.075	0	0
Carnitine shuttle	R-HSA-200425	8.420025e-01	0.075	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.421717e-01	0.075	0	0
DAP12 interactions	R-HSA-2172127	8.421717e-01	0.075	0	0
Surfactant metabolism	R-HSA-5683826	8.421717e-01	0.075	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	8.431029e-01	0.074	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.431029e-01	0.074	0	0
Dual Incision in GG-NER	R-HSA-5696400	8.449630e-01	0.073	0	0
Signaling by NOTCH2	R-HSA-1980145	8.449630e-01	0.073	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	8.449630e-01	0.073	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.466987e-01	0.072	1	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.466987e-01	0.072	1	0
Eukaryotic Translation Termination	R-HSA-72764	8.505268e-01	0.070	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.523105e-01	0.069	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	8.523105e-01	0.069	0	0
Signaling by FGFR1	R-HSA-5654736	8.523105e-01	0.069	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	8.523105e-01	0.069	0	0
Fanconi Anemia Pathway	R-HSA-6783310	8.524414e-01	0.069	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	8.524414e-01	0.069	0	0
Gastrulation	R-HSA-9758941	8.526062e-01	0.069	0	0
Adipogenesis	R-HSA-9843745	8.526683e-01	0.069	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	8.549574e-01	0.068	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	8.553001e-01	0.068	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	8.553001e-01	0.068	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	8.553001e-01	0.068	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	8.553001e-01	0.068	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	8.553001e-01	0.068	0	0
TNFs bind their physiological receptors	R-HSA-5669034	8.553001e-01	0.068	0	0
Acetylcholine binding and downstream events	R-HSA-181431	8.558908e-01	0.068	0	0
Postsynaptic nicotinic acetylcholine receptors	R-HSA-622327	8.558908e-01	0.068	0	0
FGFR2c ligand binding and activation	R-HSA-190375	8.558908e-01	0.068	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	8.558908e-01	0.068	0	0
FGFR1c ligand binding and activation	R-HSA-190373	8.558908e-01	0.068	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.558908e-01	0.068	0	0
FGFR4 ligand binding and activation	R-HSA-190322	8.558908e-01	0.068	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	8.558908e-01	0.068	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	8.558908e-01	0.068	0	0
Chylomicron remodeling	R-HSA-8963901	8.558908e-01	0.068	0	0
Mtb iron assimilation by chelation	R-HSA-1222449	8.558908e-01	0.068	0	0
Reversible hydration of carbon dioxide	R-HSA-1475029	8.558908e-01	0.068	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	8.558908e-01	0.068	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	8.558908e-01	0.068	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	8.558908e-01	0.068	0	0
Platelet Adhesion to exposed collagen	R-HSA-75892	8.558908e-01	0.068	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	8.558908e-01	0.068	0	0
Maturation of nucleoprotein	R-HSA-9683610	8.558908e-01	0.068	0	0
Interleukin-6 signaling	R-HSA-1059683	8.558908e-01	0.068	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.558908e-01	0.068	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	8.562325e-01	0.067	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	8.562325e-01	0.067	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.576694e-01	0.067	0	0
Potassium Channels	R-HSA-1296071	8.576694e-01	0.067	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	8.576694e-01	0.067	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	8.605647e-01	0.065	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.621382e-01	0.064	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	8.621382e-01	0.064	0	0
Platelet homeostasis	R-HSA-418346	8.622182e-01	0.064	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	8.641335e-01	0.063	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.667783e-01	0.062	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	8.667783e-01	0.062	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	8.675676e-01	0.062	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	8.686311e-01	0.061	0	0
Interleukin-1 family signaling	R-HSA-446652	8.692715e-01	0.061	0	0
Dual incision in TC-NER	R-HSA-6782135	8.696847e-01	0.061	0	0
Regulation of insulin secretion	R-HSA-422356	8.711345e-01	0.060	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	8.712843e-01	0.060	0	0
Retrograde neurotrophin signalling	R-HSA-177504	8.714194e-01	0.060	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.714194e-01	0.060	0	0
CRMPs in Sema3A signaling	R-HSA-399956	8.714194e-01	0.060	0	0
FGFR3c ligand binding and activation	R-HSA-190372	8.714194e-01	0.060	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	8.714194e-01	0.060	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	8.714194e-01	0.060	0	0
Biosynthesis of E-series 18(R)-resolvins	R-HSA-9023661	8.714194e-01	0.060	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	8.714194e-01	0.060	0	0
Prolactin receptor signaling	R-HSA-1170546	8.714194e-01	0.060	0	0
Vitamin B2 (riboflavin) metabolism	R-HSA-196843	8.714194e-01	0.060	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.714194e-01	0.060	0	0
Physiological factors	R-HSA-5578768	8.714194e-01	0.060	0	0
Malate-aspartate shuttle	R-HSA-9856872	8.714194e-01	0.060	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	8.714194e-01	0.060	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	8.714194e-01	0.060	0	0
HDL assembly	R-HSA-8963896	8.714194e-01	0.060	0	0
Signal regulatory protein family interactions	R-HSA-391160	8.714194e-01	0.060	0	0
Zinc transporters	R-HSA-435354	8.714194e-01	0.060	0	0
P2Y receptors	R-HSA-417957	8.714194e-01	0.060	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.714194e-01	0.060	0	0
SARS-CoV Infections	R-HSA-9679506	8.752297e-01	0.058	0	0
Ovarian tumor domain proteases	R-HSA-5689896	8.766359e-01	0.057	0	0
SLC-mediated transport of organic cations	R-HSA-549127	8.766359e-01	0.057	0	0
Interleukin-17 signaling	R-HSA-448424	8.776555e-01	0.057	1	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.777036e-01	0.057	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	8.788724e-01	0.056	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.788724e-01	0.056	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	8.788724e-01	0.056	0	0
Sphingolipid catabolism	R-HSA-9845614	8.788724e-01	0.056	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	8.799023e-01	0.056	0	0
Hedgehog 'on' state	R-HSA-5632684	8.847516e-01	0.053	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.852756e-01	0.053	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.852756e-01	0.053	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	8.852756e-01	0.053	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.852756e-01	0.053	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.852756e-01	0.053	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.852756e-01	0.053	0	0
p38MAPK events	R-HSA-171007	8.852756e-01	0.053	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	8.852756e-01	0.053	0	0
Biotin transport and metabolism	R-HSA-196780	8.852756e-01	0.053	0	0
FGFR3 ligand binding and activation	R-HSA-190239	8.852756e-01	0.053	0	0
p75NTR signals via NF-kB	R-HSA-193639	8.852756e-01	0.053	0	0
Protein methylation	R-HSA-8876725	8.852756e-01	0.053	0	0
DNA Damage Reversal	R-HSA-73942	8.852756e-01	0.053	0	0
SARS-CoV-1 Infection	R-HSA-9678108	8.881668e-01	0.052	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	8.892797e-01	0.051	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	8.892797e-01	0.051	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.892797e-01	0.051	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	8.892797e-01	0.051	0	0
Selenocysteine synthesis	R-HSA-2408557	8.893746e-01	0.051	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	8.914964e-01	0.050	0	0
SLC transporter disorders	R-HSA-5619102	8.930166e-01	0.049	0	0
Signaling by Insulin receptor	R-HSA-74752	8.931250e-01	0.049	0	0
Signaling by ALK	R-HSA-201556	8.944262e-01	0.048	0	0
Signaling by Hedgehog	R-HSA-5358351	8.959437e-01	0.048	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	8.976393e-01	0.047	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	8.976393e-01	0.047	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	8.976393e-01	0.047	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	8.976393e-01	0.047	0	0
Activation of SMO	R-HSA-5635838	8.976393e-01	0.047	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	8.976393e-01	0.047	0	0
Fructose catabolism	R-HSA-70350	8.976393e-01	0.047	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	8.976393e-01	0.047	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.976393e-01	0.047	0	0
Atorvastatin ADME	R-HSA-9754706	8.976393e-01	0.047	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	8.978997e-01	0.047	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	8.988514e-01	0.046	0	0
Pyrimidine salvage	R-HSA-73614	8.988514e-01	0.046	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	8.992797e-01	0.046	0	0
Viral mRNA Translation	R-HSA-192823	9.003059e-01	0.046	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	9.036415e-01	0.044	0	0
Collagen formation	R-HSA-1474290	9.042206e-01	0.044	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.054232e-01	0.043	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	9.076468e-01	0.042	0	0
mRNA Capping	R-HSA-72086	9.076468e-01	0.042	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	9.076468e-01	0.042	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	9.076468e-01	0.042	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	9.086712e-01	0.042	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	9.086712e-01	0.042	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	9.086712e-01	0.042	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	9.086712e-01	0.042	0	0
Vitamin B6 activation to pyridoxal phosphate	R-HSA-964975	9.086712e-01	0.042	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	9.086712e-01	0.042	0	0
Coenzyme A biosynthesis	R-HSA-196783	9.086712e-01	0.042	0	0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	R-HSA-400511	9.086712e-01	0.042	0	0
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	R-HSA-9651496	9.086712e-01	0.042	0	0
Orc1 removal from chromatin	R-HSA-68949	9.095413e-01	0.041	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	9.095413e-01	0.041	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	9.097455e-01	0.041	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.097455e-01	0.041	0	0
Maturation of spike protein	R-HSA-9694548	9.098764e-01	0.041	0	0
Toll-like Receptor Cascades	R-HSA-168898	9.117194e-01	0.040	1	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	9.117620e-01	0.040	0	0
Neddylation	R-HSA-8951664	9.139946e-01	0.039	0	0
Nucleotide Excision Repair	R-HSA-5696398	9.149952e-01	0.039	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	9.158529e-01	0.038	0	0
Smooth Muscle Contraction	R-HSA-445355	9.158529e-01	0.038	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	9.168054e-01	0.038	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.168054e-01	0.038	0	0
Neutrophil degranulation	R-HSA-6798695	9.175950e-01	0.037	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	9.185147e-01	0.037	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.185147e-01	0.037	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	9.185147e-01	0.037	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	9.185147e-01	0.037	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	9.185147e-01	0.037	0	0
Glycogen storage diseases	R-HSA-3229121	9.185147e-01	0.037	0	0
Biosynthesis of aspirin-triggered D-series resolvins	R-HSA-9020265	9.185147e-01	0.037	0	0
Sulfide oxidation to sulfate	R-HSA-1614517	9.185147e-01	0.037	0	0
Catecholamine biosynthesis	R-HSA-209905	9.185147e-01	0.037	0	0
GDP-fucose biosynthesis	R-HSA-6787639	9.185147e-01	0.037	0	0
Choline catabolism	R-HSA-6798163	9.185147e-01	0.037	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	9.185147e-01	0.037	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.203797e-01	0.036	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.231300e-01	0.035	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	9.231300e-01	0.035	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.237866e-01	0.034	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	9.272979e-01	0.033	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	9.272979e-01	0.033	0	0
Activated point mutants of FGFR2	R-HSA-2033519	9.272979e-01	0.033	0	0
FGFR1 ligand binding and activation	R-HSA-190242	9.272979e-01	0.033	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	9.272979e-01	0.033	0	0
Biosynthesis of Lipoxins (LX)	R-HSA-2142700	9.272979e-01	0.033	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.272979e-01	0.033	0	0
GAB1 signalosome	R-HSA-180292	9.272979e-01	0.033	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	9.272979e-01	0.033	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.272979e-01	0.033	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	9.273070e-01	0.033	0	0
Signaling by FGFR	R-HSA-190236	9.277633e-01	0.033	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	9.292254e-01	0.032	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	9.299208e-01	0.032	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.324898e-01	0.030	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	9.326995e-01	0.030	0	0
Cellular response to chemical stress	R-HSA-9711123	9.332829e-01	0.030	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.351347e-01	0.029	0	0
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	9.351347e-01	0.029	0	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.351347e-01	0.029	0	0
Diseases of hemostasis	R-HSA-9671793	9.351347e-01	0.029	0	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.351347e-01	0.029	0	0
Maturation of nucleoprotein	R-HSA-9694631	9.351347e-01	0.029	0	0
Other interleukin signaling	R-HSA-449836	9.351347e-01	0.029	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.351347e-01	0.029	0	0
TCR signaling	R-HSA-202403	9.353812e-01	0.029	0	0
SARS-CoV-2 Infection	R-HSA-9694516	9.359189e-01	0.029	0	0
Cellular response to starvation	R-HSA-9711097	9.361105e-01	0.029	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.361413e-01	0.029	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	9.361413e-01	0.029	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.399192e-01	0.027	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	9.418356e-01	0.026	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.418356e-01	0.026	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.418633e-01	0.026	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.421272e-01	0.026	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.421272e-01	0.026	0	0
Glycogen synthesis	R-HSA-3322077	9.421272e-01	0.026	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.421272e-01	0.026	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.421272e-01	0.026	0	0
Signaling by NODAL	R-HSA-1181150	9.421272e-01	0.026	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.421759e-01	0.026	0	0
tRNA processing	R-HSA-72306	9.430516e-01	0.025	0	0
Transmission across Chemical Synapses	R-HSA-112315	9.439524e-01	0.025	1	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.458309e-01	0.024	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.459731e-01	0.024	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	9.470447e-01	0.024	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	9.472676e-01	0.024	1	0
FGFR2 ligand binding and activation	R-HSA-190241	9.483663e-01	0.023	0	0
G-protein activation	R-HSA-202040	9.483663e-01	0.023	0	0
Matriglycan biosynthesis on DAG1	R-HSA-9939291	9.483663e-01	0.023	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	9.483663e-01	0.023	0	0
Biosynthesis of E-series 18(S)-resolvins	R-HSA-9018896	9.483663e-01	0.023	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.483663e-01	0.023	0	0
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	9.483663e-01	0.023	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.483663e-01	0.023	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.483663e-01	0.023	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.490811e-01	0.023	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	9.490992e-01	0.023	0	0
GABA receptor activation	R-HSA-977443	9.500345e-01	0.022	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.500345e-01	0.022	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.518071e-01	0.021	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.518071e-01	0.021	0	0
Oncogene Induced Senescence	R-HSA-2559585	9.518071e-01	0.021	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.518071e-01	0.021	0	0
GPER1 signaling	R-HSA-9634597	9.531824e-01	0.021	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	9.539331e-01	0.020	0	0
Attachment and Entry	R-HSA-9694614	9.539331e-01	0.020	0	0
Assembly Of The HIV Virion	R-HSA-175474	9.539331e-01	0.020	0	0
Glutathione synthesis and recycling	R-HSA-174403	9.539331e-01	0.020	0	0
Signaling by NOTCH4	R-HSA-9013694	9.558339e-01	0.020	0	0
HSF1 activation	R-HSA-3371511	9.561585e-01	0.019	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.561585e-01	0.019	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.561585e-01	0.019	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.561585e-01	0.019	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	9.588942e-01	0.018	0	0
Biosynthesis of D-series resolvins	R-HSA-9018676	9.589000e-01	0.018	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.589000e-01	0.018	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.589000e-01	0.018	0	0
LDL clearance	R-HSA-8964038	9.589000e-01	0.018	0	0
Fructose metabolism	R-HSA-5652084	9.589000e-01	0.018	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.589000e-01	0.018	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.589000e-01	0.018	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.589000e-01	0.018	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.589000e-01	0.018	0	0
Leishmania infection	R-HSA-9658195	9.596765e-01	0.018	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.596765e-01	0.018	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.601322e-01	0.018	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.601322e-01	0.018	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	9.601322e-01	0.018	0	0
Degradation of DVL	R-HSA-4641258	9.601322e-01	0.018	0	0
Collagen chain trimerization	R-HSA-8948216	9.601322e-01	0.018	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	9.605211e-01	0.017	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.633316e-01	0.016	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	9.633316e-01	0.016	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	9.633316e-01	0.016	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	9.633316e-01	0.016	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	9.633316e-01	0.016	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.633316e-01	0.016	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	9.633316e-01	0.016	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.633316e-01	0.016	0	0
Organic anion transport by SLCO transporters	R-HSA-879518	9.633316e-01	0.016	0	0
Biosynthesis of maresins	R-HSA-9018682	9.633316e-01	0.016	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	9.636679e-01	0.016	0	0
Elastic fibre formation	R-HSA-1566948	9.637590e-01	0.016	0	0
rRNA processing	R-HSA-72312	9.644177e-01	0.016	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	9.647934e-01	0.016	0	0
Phospholipid metabolism	R-HSA-1483257	9.652710e-01	0.015	0	0
Cellular response to hypoxia	R-HSA-1234174	9.660605e-01	0.015	0	0
Stabilization of p53	R-HSA-69541	9.670675e-01	0.015	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.670675e-01	0.015	0	0
Translocation of ZAP-70 to Immunological synapse	R-HSA-202430	9.672856e-01	0.014	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	9.672856e-01	0.014	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	9.672856e-01	0.014	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.672856e-01	0.014	0	0
Plasma lipoprotein assembly	R-HSA-8963898	9.672856e-01	0.014	0	0
Interleukin-6 family signaling	R-HSA-6783589	9.672856e-01	0.014	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	9.680419e-01	0.014	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.700841e-01	0.013	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.700841e-01	0.013	0	0
Interleukin-1 signaling	R-HSA-9020702	9.705663e-01	0.013	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	9.708135e-01	0.013	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.708135e-01	0.013	0	0
G protein gated Potassium channels	R-HSA-1296059	9.708135e-01	0.013	0	0
Alpha-oxidation of phytanate	R-HSA-389599	9.708135e-01	0.013	0	0
Laminin interactions	R-HSA-3000157	9.708135e-01	0.013	0	0
Hyaluronan degradation	R-HSA-2160916	9.708135e-01	0.013	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.708135e-01	0.013	0	0
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	R-HSA-9027604	9.708135e-01	0.013	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.728333e-01	0.012	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	9.728333e-01	0.012	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.728333e-01	0.012	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.732274e-01	0.012	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.739611e-01	0.011	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	9.739611e-01	0.011	0	0
Metalloprotease DUBs	R-HSA-5689901	9.739611e-01	0.011	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	9.739611e-01	0.011	0	0
Urea cycle	R-HSA-70635	9.739611e-01	0.011	0	0
Abacavir ADME	R-HSA-2161522	9.739611e-01	0.011	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.742412e-01	0.011	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.753377e-01	0.011	0	0
HIV Transcription Initiation	R-HSA-167161	9.753377e-01	0.011	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.753377e-01	0.011	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.753377e-01	0.011	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.753377e-01	0.011	0	0
Translation of Structural Proteins	R-HSA-9683701	9.753377e-01	0.011	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.767694e-01	0.010	0	0
Biosynthesis of DPAn-3 SPMs	R-HSA-9025094	9.767694e-01	0.010	0	0
Triglyceride biosynthesis	R-HSA-75109	9.767694e-01	0.010	0	0
Synthesis of PE	R-HSA-1483213	9.767694e-01	0.010	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.767694e-01	0.010	0	0
Insulin processing	R-HSA-264876	9.767694e-01	0.010	0	0
Signaling by BMP	R-HSA-201451	9.767694e-01	0.010	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.771887e-01	0.010	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.789559e-01	0.009	0	0
Prednisone ADME	R-HSA-9757110	9.792750e-01	0.009	0	0
Insulin receptor recycling	R-HSA-77387	9.792750e-01	0.009	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	9.796937e-01	0.009	0	0
Vesicle-mediated transport	R-HSA-5653656	9.798945e-01	0.009	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.801774e-01	0.009	0	0
Platelet degranulation	R-HSA-114608	9.803900e-01	0.009	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.808474e-01	0.008	0	0
Thyroxine biosynthesis	R-HSA-209968	9.815105e-01	0.008	0	0
Biosynthesis of EPA-derived SPMs	R-HSA-9018679	9.815105e-01	0.008	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.815105e-01	0.008	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	9.815105e-01	0.008	0	0
Regulation of gene expression in beta cells	R-HSA-210745	9.815105e-01	0.008	0	0
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	9.815821e-01	0.008	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.818406e-01	0.008	0	0
COPI-mediated anterograde transport	R-HSA-6807878	9.821811e-01	0.008	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	9.829588e-01	0.007	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.832995e-01	0.007	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	9.832995e-01	0.007	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	9.835050e-01	0.007	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	9.835050e-01	0.007	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.835050e-01	0.007	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.835139e-01	0.007	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.839793e-01	0.007	0	0
Leishmania phagocytosis	R-HSA-9664417	9.839793e-01	0.007	0	0
Parasite infection	R-HSA-9664407	9.839793e-01	0.007	0	0
Chaperonin-mediated protein folding	R-HSA-390466	9.844237e-01	0.007	0	0
Nucleotide salvage	R-HSA-8956321	9.847936e-01	0.007	0	0
Collagen degradation	R-HSA-1442490	9.847936e-01	0.007	0	0
Iron uptake and transport	R-HSA-917937	9.848130e-01	0.007	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.848608e-01	0.007	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.848608e-01	0.007	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.852844e-01	0.006	0	0
Biosynthesis of DPA-derived SPMs	R-HSA-9018683	9.852844e-01	0.006	0	0
Cargo concentration in the ER	R-HSA-5694530	9.852844e-01	0.006	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	9.852844e-01	0.006	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.852844e-01	0.006	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.852844e-01	0.006	0	0
UCH proteinases	R-HSA-5689603	9.860145e-01	0.006	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.860890e-01	0.006	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.862798e-01	0.006	0	0
DAG1 glycosylations	R-HSA-8931838	9.868719e-01	0.006	0	0
HS-GAG degradation	R-HSA-2024096	9.868719e-01	0.006	0	0
Hemostasis	R-HSA-109582	9.870905e-01	0.006	0	0
Translation of Structural Proteins	R-HSA-9694635	9.871252e-01	0.006	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.874877e-01	0.005	0	0
Intraflagellar transport	R-HSA-5620924	9.875689e-01	0.005	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.875689e-01	0.005	0	0
Gluconeogenesis	R-HSA-70263	9.875689e-01	0.005	0	0
PCP/CE pathway	R-HSA-4086400	9.881517e-01	0.005	0	0
Interleukin-10 signaling	R-HSA-6783783	9.881517e-01	0.005	0	0
Integrin cell surface interactions	R-HSA-216083	9.881517e-01	0.005	0	0
Recycling of bile acids and salts	R-HSA-159418	9.882883e-01	0.005	0	0
Degradation of CDH1	R-HSA-9766229	9.887396e-01	0.005	0	0
Vpu mediated degradation of CD4	R-HSA-180534	9.895520e-01	0.005	0	0
Miscellaneous transport and binding events	R-HSA-5223345	9.895520e-01	0.005	0	0
Heme degradation	R-HSA-189483	9.895520e-01	0.005	0	0
Protein folding	R-HSA-391251	9.902491e-01	0.004	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.902491e-01	0.004	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.902871e-01	0.004	0	0
Interferon gamma signaling	R-HSA-877300	9.903743e-01	0.004	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.906793e-01	0.004	0	0
eNOS activation	R-HSA-203615	9.906793e-01	0.004	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.906793e-01	0.004	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.906793e-01	0.004	0	0
Signal amplification	R-HSA-392518	9.906793e-01	0.004	0	0
Hyaluronan metabolism	R-HSA-2142845	9.906793e-01	0.004	0	0
Mitophagy	R-HSA-5205647	9.906793e-01	0.004	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.906793e-01	0.004	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.906793e-01	0.004	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.907672e-01	0.004	0	0
The phototransduction cascade	R-HSA-2514856	9.907672e-01	0.004	0	0
RSV-host interactions	R-HSA-9833110	9.908332e-01	0.004	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.909334e-01	0.004	0	0
Ribosome-associated quality control	R-HSA-9948299	9.915857e-01	0.004	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.916426e-01	0.004	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.916851e-01	0.004	0	0
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	R-HSA-193775	9.916851e-01	0.004	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	9.924366e-01	0.003	0	0
HS-GAG biosynthesis	R-HSA-2022928	9.925824e-01	0.003	0	0
Triglyceride catabolism	R-HSA-163560	9.925824e-01	0.003	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.932496e-01	0.003	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.933829e-01	0.003	0	0
NCAM1 interactions	R-HSA-419037	9.933829e-01	0.003	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.933829e-01	0.003	0	0
Lysine catabolism	R-HSA-71064	9.933829e-01	0.003	0	0
Paracetamol ADME	R-HSA-9753281	9.938093e-01	0.003	0	0
Signaling by NOTCH3	R-HSA-9012852	9.938093e-01	0.003	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.940971e-01	0.003	0	0
Purine salvage	R-HSA-74217	9.940971e-01	0.003	0	0
Immune System	R-HSA-168256	9.944834e-01	0.002	1	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.947342e-01	0.002	0	0
Plasma lipoprotein clearance	R-HSA-8964043	9.947342e-01	0.002	0	0
Pentose phosphate pathway	R-HSA-71336	9.947342e-01	0.002	0	0
Regulation of CDH1 Function	R-HSA-9764561	9.949370e-01	0.002	0	0
Dectin-2 family	R-HSA-5621480	9.949370e-01	0.002	0	0
Synthesis of PA	R-HSA-1483166	9.949370e-01	0.002	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	9.953026e-01	0.002	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.953026e-01	0.002	0	0
Interferon Signaling	R-HSA-913531	9.954830e-01	0.002	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.958097e-01	0.002	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.958097e-01	0.002	0	0
Aflatoxin activation and detoxification	R-HSA-5423646	9.958097e-01	0.002	0	0
Peroxisomal protein import	R-HSA-9033241	9.958625e-01	0.002	0	0
Triglyceride metabolism	R-HSA-8979227	9.958625e-01	0.002	0	0
Regulation of beta-cell development	R-HSA-186712	9.958625e-01	0.002	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.958625e-01	0.002	0	0
Viral Infection Pathways	R-HSA-9824446	9.959038e-01	0.002	0	0
Downstream TCR signaling	R-HSA-202424	9.960849e-01	0.002	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	9.962453e-01	0.002	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.962607e-01	0.002	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.966656e-01	0.001	0	0
Activation of GABAB receptors	R-HSA-991365	9.966656e-01	0.001	0	0
GABA B receptor activation	R-HSA-977444	9.966656e-01	0.001	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.966656e-01	0.001	0	0
Cholesterol biosynthesis	R-HSA-191273	9.967796e-01	0.001	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.968737e-01	0.001	0	0
Mitochondrial protein import	R-HSA-1268020	9.969474e-01	0.001	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.969874e-01	0.001	0	0
Defensins	R-HSA-1461973	9.970256e-01	0.001	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.970256e-01	0.001	0	0
Pyrimidine catabolism	R-HSA-73621	9.970256e-01	0.001	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.970305e-01	0.001	0	0
PKR-mediated signaling	R-HSA-9833482	9.973298e-01	0.001	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.973467e-01	0.001	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.974465e-01	0.001	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.974465e-01	0.001	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.976332e-01	0.001	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.976332e-01	0.001	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	9.976332e-01	0.001	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.977549e-01	0.001	0	0
Synthesis of PC	R-HSA-1483191	9.981168e-01	0.001	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.981673e-01	0.001	0	0
Nicotinate metabolism	R-HSA-196807	9.981673e-01	0.001	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.981673e-01	0.001	0	0
Metabolism of steroid hormones	R-HSA-196071	9.981673e-01	0.001	0	0
G alpha (s) signalling events	R-HSA-418555	9.982067e-01	0.001	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	9.983336e-01	0.001	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.983459e-01	0.001	0	0
Gap junction trafficking and regulation	R-HSA-157858	9.985016e-01	0.001	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.985016e-01	0.001	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.985016e-01	0.001	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.986231e-01	0.001	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.986446e-01	0.001	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.987181e-01	0.001	0	0
Retinoid metabolism and transport	R-HSA-975634	9.987848e-01	0.001	0	0
Metabolism of cofactors	R-HSA-8978934	9.987848e-01	0.001	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.988078e-01	0.001	0	0
Complex IV assembly	R-HSA-9864848	9.988078e-01	0.001	0	0
G alpha (q) signalling events	R-HSA-416476	9.989269e-01	0.000	1	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.990113e-01	0.000	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.990515e-01	0.000	0	0
Neurotransmitter release cycle	R-HSA-112310	9.990610e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.992804e-01	0.000	0	0
Digestion	R-HSA-8935690	9.993269e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.993270e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.994110e-01	0.000	0	0
Formation of the cornified envelope	R-HSA-6809371	9.995215e-01	0.000	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.995224e-01	0.000	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.995689e-01	0.000	0	0
tRNA Aminoacylation	R-HSA-379724	9.995740e-01	0.000	0	0
Glutathione conjugation	R-HSA-156590	9.995740e-01	0.000	0	0
Endogenous sterols	R-HSA-211976	9.996200e-01	0.000	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.996200e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.996436e-01	0.000	0	0
Protein localization	R-HSA-9609507	9.996474e-01	0.000	0	0
Digestion and absorption	R-HSA-8963743	9.996977e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.997387e-01	0.000	0	0
Latent infection - Other responses of Mtb to phagocytosis	R-HSA-1222499	9.997596e-01	0.000	0	0
Pyruvate metabolism	R-HSA-70268	9.997927e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.998019e-01	0.000	1	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.998134e-01	0.000	0	0
ER-Phagosome pathway	R-HSA-1236974	9.998320e-01	0.000	0	0
ECM proteoglycans	R-HSA-3000178	9.998790e-01	0.000	0	0
Metabolism of porphyrins	R-HSA-189445	9.998790e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.998850e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.998921e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999104e-01	0.000	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.999108e-01	0.000	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.999234e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.999291e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999350e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.999391e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999391e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999399e-01	0.000	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.999445e-01	0.000	0	0
ABC transporter disorders	R-HSA-5619084	9.999457e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.999527e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.999597e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999615e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999727e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999750e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999784e-01	0.000	1	0
Sulfur amino acid metabolism	R-HSA-1614635	9.999806e-01	0.000	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.999816e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.999869e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999878e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.999884e-01	0.000	1	0
FCERI mediated MAPK activation	R-HSA-2871796	9.999894e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999916e-01	0.000	0	0
Post-translational protein modification	R-HSA-597592	9.999941e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999983e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999985e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999988e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999988e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999990e-01	0.000	0	0
Sensory perception of taste	R-HSA-9717189	9.999991e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999991e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999992e-01	0.000	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.999996e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999997e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.999998e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999998e-01	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	9.999998e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999998e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999999e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999999e-01	0.000	0	0
Disease	R-HSA-1643685	9.999999e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	9.999999e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999999e-01	0.000	0	0
Infectious disease	R-HSA-5663205	9.999999e-01	0.000	0	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	1.000000e+00	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Complement cascade	R-HSA-166658	1.000000e+00	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000	0	0
Translation	R-HSA-72766	1.000000e+00	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	1.000000e+00	0.000	0	0
Respiratory electron transport	R-HSA-611105	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
HSF1-dependent transactivation	R-HSA-3371571	2.049139e-12	11.688	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	5.848322e-12	11.233	0	0
Attenuation phase	R-HSA-3371568	1.739719e-11	10.760	0	0
Cellular response to heat stress	R-HSA-3371556	2.601663e-11	10.585	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.374354e-10	9.359	0	0
Chromatin organization	R-HSA-4839726	5.014893e-10	9.300	0	0
Chromatin modifying enzymes	R-HSA-3247509	1.150978e-09	8.939	0	0
Cell Cycle	R-HSA-1640170	2.871996e-09	8.542	0	0
HSF1 activation	R-HSA-3371511	3.856235e-09	8.414	0	0
Cell Cycle, Mitotic	R-HSA-69278	2.257532e-08	7.646	0	0
Cellular responses to stimuli	R-HSA-8953897	2.932128e-08	7.533	1	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.106530e-07	6.956	0	0
Cellular responses to stress	R-HSA-2262752	2.375839e-07	6.624	1	0
M Phase	R-HSA-68886	2.783020e-07	6.555	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.506374e-07	6.455	0	0
Cell-Cell communication	R-HSA-1500931	4.406167e-07	6.356	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	5.196645e-07	6.284	0	0
PRC2 methylates histones and DNA	R-HSA-212300	5.180547e-07	6.286	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	5.748547e-07	6.240	0	0
Signaling by ALK in cancer	R-HSA-9700206	5.748547e-07	6.240	0	0
mRNA Splicing	R-HSA-72172	6.019153e-07	6.220	0	0
Apoptotic execution phase	R-HSA-75153	6.407448e-07	6.193	0	0
Meiotic synapsis	R-HSA-1221632	9.601265e-07	6.018	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	9.379842e-07	6.028	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	9.177807e-07	6.037	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.050697e-06	5.979	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.085980e-06	5.964	0	0
Signal Transduction	R-HSA-162582	1.570606e-06	5.804	1	0
Nucleosome assembly	R-HSA-774815	2.032977e-06	5.692	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.032977e-06	5.692	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	2.415024e-06	5.617	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	2.559409e-06	5.592	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	2.559409e-06	5.592	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	3.083290e-06	5.511	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	4.757060e-06	5.323	0	0
Cell junction organization	R-HSA-446728	4.772162e-06	5.321	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	5.926588e-06	5.227	0	0
DNA Double Strand Break Response	R-HSA-5693606	5.829808e-06	5.234	0	0
Mitotic Prophase	R-HSA-68875	5.849391e-06	5.233	0	0
Cell Cycle Checkpoints	R-HSA-69620	6.847644e-06	5.164	0	0
PKMTs methylate histone lysines	R-HSA-3214841	9.231052e-06	5.035	0	0
HATs acetylate histones	R-HSA-3214847	9.587566e-06	5.018	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	1.018955e-05	4.992	0	0
Cellular Senescence	R-HSA-2559583	1.329044e-05	4.876	1	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	1.689811e-05	4.772	0	0
Defective pyroptosis	R-HSA-9710421	1.910956e-05	4.719	0	0
DNA methylation	R-HSA-5334118	2.075420e-05	4.683	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	2.101123e-05	4.678	0	0
G2/M DNA damage checkpoint	R-HSA-69473	2.142608e-05	4.669	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.290398e-05	4.640	0	0
Processing of DNA double-strand break ends	R-HSA-5693607	2.335636e-05	4.632	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.751941e-05	4.560	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	2.835767e-05	4.547	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.835767e-05	4.547	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	3.122254e-05	4.506	0	0
mRNA 3'-end processing	R-HSA-72187	3.758739e-05	4.425	0	0
ESR-mediated signaling	R-HSA-8939211	3.843949e-05	4.415	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	3.890668e-05	4.410	0	0
Regulation of endogenous retroelements	R-HSA-9842860	4.063528e-05	4.391	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	4.591540e-05	4.338	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	4.612296e-05	4.336	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	4.758663e-05	4.323	0	0
Packaging Of Telomere Ends	R-HSA-171306	5.197224e-05	4.284	0	0
Epigenetic regulation of gene expression	R-HSA-212165	4.978425e-05	4.303	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.155158e-05	4.288	0	0
RNA Polymerase I Promoter Opening	R-HSA-73728	5.197224e-05	4.284	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	4.998793e-05	4.301	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	5.450840e-05	4.264	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	5.701344e-05	4.244	0	0
Adherens junctions interactions	R-HSA-418990	6.087940e-05	4.216	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	6.159361e-05	4.210	0	0
Estrogen-dependent gene expression	R-HSA-9018519	6.506052e-05	4.187	0	0
Nervous system development	R-HSA-9675108	6.473843e-05	4.189	1	0
HDACs deacetylate histones	R-HSA-3214815	6.759913e-05	4.170	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.644210e-05	4.117	0	0
Diseases of programmed cell death	R-HSA-9645723	8.070230e-05	4.093	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	1.006330e-04	3.997	0	0
Axon guidance	R-HSA-422475	1.027757e-04	3.988	1	0
Oxidative Stress Induced Senescence	R-HSA-2559580	1.054510e-04	3.977	0	0
Meiosis	R-HSA-1500620	1.228590e-04	3.911	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	1.276230e-04	3.894	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.800512e-04	3.745	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	1.824036e-04	3.739	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.955776e-04	3.709	0	0
Signaling by VEGF	R-HSA-194138	1.902357e-04	3.721	0	0
Cleavage of the damaged purine	R-HSA-110331	1.985492e-04	3.702	0	0
Apoptosis	R-HSA-109581	2.175006e-04	3.663	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	2.304393e-04	3.637	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	2.428129e-04	3.615	0	0
Depurination	R-HSA-73927	2.456207e-04	3.610	0	0
Cell-cell junction organization	R-HSA-421270	2.368792e-04	3.625	0	0
Membrane Trafficking	R-HSA-199991	2.765737e-04	3.558	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	2.846738e-04	3.546	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.921216e-04	3.534	0	0
Oncogenic MAPK signaling	R-HSA-6802957	3.258596e-04	3.487	0	0
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	3.284136e-04	3.484	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	3.693883e-04	3.433	0	0
Homology Directed Repair	R-HSA-5693538	4.172618e-04	3.380	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	4.480467e-04	3.349	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	4.225285e-04	3.374	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	4.225285e-04	3.374	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	4.225285e-04	3.374	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	4.480467e-04	3.349	0	0
Signaling by RAS mutants	R-HSA-6802949	4.225285e-04	3.374	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	4.571219e-04	3.340	0	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	4.974334e-04	3.303	0	0
G2/M Checkpoints	R-HSA-69481	5.300952e-04	3.276	0	0
Regulation of TP53 Degradation	R-HSA-6804757	5.649923e-04	3.248	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	5.637971e-04	3.249	1	1
Intracellular signaling by second messengers	R-HSA-9006925	5.707879e-04	3.244	0	0
Chromosome Maintenance	R-HSA-73886	5.727532e-04	3.242	0	0
Signaling by WNT	R-HSA-195721	5.741972e-04	3.241	0	0
Deubiquitination	R-HSA-5688426	5.885550e-04	3.230	0	0
Programmed Cell Death	R-HSA-5357801	6.306424e-04	3.200	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	6.501735e-04	3.187	0	0
Depyrimidination	R-HSA-73928	6.501735e-04	3.187	0	0
Interleukin-12 signaling	R-HSA-9020591	6.569398e-04	3.182	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	6.628967e-04	3.179	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	6.881217e-04	3.162	0	0
L1CAM interactions	R-HSA-373760	7.600719e-04	3.119	1	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	7.351666e-04	3.134	1	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	7.622230e-04	3.118	0	0
Mitotic Anaphase	R-HSA-68882	7.666151e-04	3.115	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	8.254163e-04	3.083	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	9.384031e-04	3.028	0	0
Meiotic recombination	R-HSA-912446	9.810422e-04	3.008	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	1.002365e-03	2.999	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	1.002365e-03	2.999	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	1.146627e-03	2.941	0	0
Metabolism of RNA	R-HSA-8953854	1.100007e-03	2.959	0	0
Interleukin-12 family signaling	R-HSA-447115	1.184192e-03	2.927	0	0
Gene Silencing by RNA	R-HSA-211000	1.209074e-03	2.918	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	1.352313e-03	2.869	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	1.427670e-03	2.845	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	1.548610e-03	2.810	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.548783e-03	2.810	0	0
Reproduction	R-HSA-1474165	1.655411e-03	2.781	0	0
Signaling by RAF1 mutants	R-HSA-9656223	1.690539e-03	2.772	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.708027e-03	2.768	0	0
Cell-extracellular matrix interactions	R-HSA-446353	1.708027e-03	2.768	0	0
DNA Double-Strand Break Repair	R-HSA-5693532	1.723197e-03	2.764	0	0
Semaphorin interactions	R-HSA-373755	2.026260e-03	2.693	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	2.042387e-03	2.690	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	2.042387e-03	2.690	0	0
G alpha (12/13) signalling events	R-HSA-416482	2.111322e-03	2.675	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.210987e-03	2.655	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	2.219871e-03	2.654	0	0
Amplification of signal from the kinetochores	R-HSA-141424	2.227259e-03	2.652	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	2.227259e-03	2.652	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	2.618567e-03	2.582	0	0
G-protein beta:gamma signalling	R-HSA-397795	2.880066e-03	2.541	0	0
Mitotic Prometaphase	R-HSA-68877	2.944736e-03	2.531	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	3.161768e-03	2.500	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.434632e-03	2.464	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	3.980550e-03	2.400	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	3.852793e-03	2.414	0	0
Base Excision Repair	R-HSA-73884	3.793049e-03	2.421	0	0
PIP3 activates AKT signaling	R-HSA-1257604	4.004916e-03	2.397	0	0
DNA Repair	R-HSA-73894	4.102904e-03	2.387	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	4.227364e-03	2.374	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	4.227364e-03	2.374	0	0
Recycling pathway of L1	R-HSA-437239	4.228884e-03	2.374	1	1
Telomere Maintenance	R-HSA-157579	4.230662e-03	2.374	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	4.402467e-03	2.356	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	4.598799e-03	2.337	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	5.345753e-03	2.272	0	0
EPH-Ephrin signaling	R-HSA-2682334	5.107566e-03	2.292	0	0
Signaling by EGFR	R-HSA-177929	5.345753e-03	2.272	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	4.828554e-03	2.316	0	0
RNA Polymerase I Transcription	R-HSA-73864	4.948345e-03	2.306	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	5.319256e-03	2.274	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	4.994512e-03	2.302	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.096441e-03	2.293	0	0
NRAGE signals death through JNK	R-HSA-193648	5.345753e-03	2.272	0	0
Assembly of the pre-replicative complex	R-HSA-68867	5.620843e-03	2.250	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.879021e-03	2.231	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	6.040219e-03	2.219	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	6.099569e-03	2.215	0	0
EGFR downregulation	R-HSA-182971	6.351070e-03	2.197	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	6.550180e-03	2.184	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	6.624272e-03	2.179	0	0
Death Receptor Signaling	R-HSA-73887	6.719145e-03	2.173	0	0
Eukaryotic Translation Initiation	R-HSA-72613	6.979627e-03	2.156	0	0
Cap-dependent Translation Initiation	R-HSA-72737	6.979627e-03	2.156	0	0
Sema4D in semaphorin signaling	R-HSA-400685	7.014840e-03	2.154	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	7.417034e-03	2.130	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	7.462280e-03	2.127	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	7.462280e-03	2.127	0	0
Signal transduction by L1	R-HSA-445144	7.462280e-03	2.127	0	0
Negative regulation of MET activity	R-HSA-6807004	7.462280e-03	2.127	0	0
EPHB-mediated forward signaling	R-HSA-3928662	7.469700e-03	2.127	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	8.140160e-03	2.089	0	0
Kinesins	R-HSA-983189	8.598284e-03	2.066	0	0
Protein ubiquitination	R-HSA-8852135	8.156565e-03	2.088	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	8.762964e-03	2.057	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	8.762964e-03	2.057	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	8.764847e-03	2.057	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	9.184461e-03	2.037	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	9.695822e-03	2.013	0	0
IRE1alpha activates chaperones	R-HSA-381070	9.831986e-03	2.007	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	9.955624e-03	2.002	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.006747e-02	1.997	0	0
Translation initiation complex formation	R-HSA-72649	1.033009e-02	1.986	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	1.043264e-02	1.982	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	1.050886e-02	1.978	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	1.103131e-02	1.957	0	0
Signaling by AMER1 mutants	R-HSA-4839748	1.134399e-02	1.945	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	1.134399e-02	1.945	0	0
RAF activation	R-HSA-5673000	1.181219e-02	1.928	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.251933e-02	1.902	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	1.251933e-02	1.902	0	0
DNA Replication Pre-Initiation	R-HSA-69002	1.297508e-02	1.887	0	0
Separation of Sister Chromatids	R-HSA-2467813	1.299723e-02	1.886	0	0
MAP2K and MAPK activation	R-HSA-5674135	1.310893e-02	1.882	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	1.310893e-02	1.882	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.381320e-02	1.860	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.381320e-02	1.860	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.381320e-02	1.860	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.381320e-02	1.860	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.381320e-02	1.860	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	1.372549e-02	1.862	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	1.464952e-02	1.834	0	0
Regulation of CDH1 Function	R-HSA-9764561	1.443693e-02	1.841	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	1.459689e-02	1.836	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.569935e-02	1.804	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	1.595845e-02	1.797	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	1.605002e-02	1.795	0	0
Signaling by ROBO receptors	R-HSA-376176	1.620002e-02	1.790	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	1.663673e-02	1.779	0	0
Type I hemidesmosome assembly	R-HSA-446107	1.712468e-02	1.766	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	1.712468e-02	1.766	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	1.712468e-02	1.766	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	1.746933e-02	1.758	0	0
HCMV Early Events	R-HSA-9609690	1.822047e-02	1.739	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	1.842206e-02	1.735	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	1.844261e-02	1.734	0	0
Gene expression (Transcription)	R-HSA-74160	1.894002e-02	1.723	0	0
PLC beta mediated events	R-HSA-112043	2.170870e-02	1.663	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	2.266474e-02	1.645	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	2.276906e-02	1.643	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	2.285454e-02	1.641	0	0
Ub-specific processing proteases	R-HSA-5689880	2.330904e-02	1.632	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	2.368060e-02	1.626	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	2.372701e-02	1.625	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	2.410202e-02	1.618	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	2.421892e-02	1.616	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	2.421892e-02	1.616	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	2.442829e-02	1.612	0	0
Manipulation of host energy metabolism	R-HSA-9636667	2.934070e-02	1.533	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.478081e-02	1.606	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	2.917954e-02	1.535	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	2.917954e-02	1.535	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.792407e-02	1.554	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	2.893516e-02	1.539	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.753663e-02	1.560	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	2.799491e-02	1.553	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	2.670603e-02	1.573	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	2.670603e-02	1.573	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	2.670603e-02	1.573	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	2.917954e-02	1.535	0	0
Breakdown of the nuclear lamina	R-HSA-352238	2.934070e-02	1.533	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	2.893516e-02	1.539	0	0
Rab regulation of trafficking	R-HSA-9007101	2.650999e-02	1.577	0	0
Co-stimulation by CD28	R-HSA-389356	2.927925e-02	1.533	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	2.792407e-02	1.554	0	0
Nephrin family interactions	R-HSA-373753	2.494932e-02	1.603	0	0
Amyloid fiber formation	R-HSA-977225	2.936575e-02	1.532	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	3.115422e-02	1.506	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	3.208016e-02	1.494	0	0
Signaling by FGFR in disease	R-HSA-1226099	3.307010e-02	1.481	0	0
DNA Replication	R-HSA-69306	3.338895e-02	1.476	0	0
Prolonged ERK activation events	R-HSA-169893	3.365481e-02	1.473	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	3.430788e-02	1.465	0	0
Vesicle-mediated transport	R-HSA-5653656	3.466329e-02	1.460	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	3.470852e-02	1.460	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	3.489827e-02	1.457	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.508900e-02	1.455	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.522292e-02	1.453	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	3.532419e-02	1.452	0	0
Ca-dependent events	R-HSA-111996	3.582069e-02	1.446	0	0
Signaling by APC mutants	R-HSA-4839744	3.669467e-02	1.435	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	3.669467e-02	1.435	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	3.669467e-02	1.435	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	3.669467e-02	1.435	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	3.669467e-02	1.435	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	3.701629e-02	1.432	0	0
G-protein mediated events	R-HSA-112040	3.724667e-02	1.429	0	0
MHC class II antigen presentation	R-HSA-2132295	3.863348e-02	1.413	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	3.896179e-02	1.409	0	0
Calmodulin induced events	R-HSA-111933	3.934400e-02	1.405	0	0
CaM pathway	R-HSA-111997	3.934400e-02	1.405	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	4.118204e-02	1.385	0	0
RNA Polymerase II Transcription	R-HSA-73857	4.168322e-02	1.380	0	0
Signaling by ERBB2	R-HSA-1227986	4.195059e-02	1.377	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	4.377481e-02	1.359	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	4.926444e-02	1.307	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	4.926444e-02	1.307	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	4.926444e-02	1.307	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	4.926444e-02	1.307	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	4.926444e-02	1.307	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	4.926444e-02	1.307	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	4.926444e-02	1.307	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	4.926444e-02	1.307	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	4.926444e-02	1.307	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	4.926444e-02	1.307	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	4.926444e-02	1.307	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	4.522200e-02	1.345	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	5.476060e-02	1.262	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	5.476060e-02	1.262	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	5.476060e-02	1.262	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	5.476060e-02	1.262	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	5.476060e-02	1.262	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	4.567544e-02	1.340	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	5.297779e-02	1.276	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	4.944798e-02	1.306	0	0
DAG and IP3 signaling	R-HSA-1489509	4.839253e-02	1.315	0	0
Signaling by MET	R-HSA-6806834	5.221069e-02	1.282	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.373940e-02	1.270	0	0
Signaling by PTK6	R-HSA-8848021	5.373940e-02	1.270	0	0
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.926444e-02	1.307	0	0
Signaling by AXIN mutants	R-HSA-4839735	4.522200e-02	1.345	0	0
Regulation of IFNG signaling	R-HSA-877312	5.476060e-02	1.262	0	0
Opioid Signalling	R-HSA-111885	5.289806e-02	1.277	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	5.221069e-02	1.282	0	0
Signaling by Hippo	R-HSA-2028269	4.716779e-02	1.326	0	0
Ephrin signaling	R-HSA-3928664	5.496954e-02	1.260	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	5.496954e-02	1.260	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	5.504646e-02	1.259	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	5.974151e-02	1.224	0	0
Integrin signaling	R-HSA-354192	6.028843e-02	1.220	0	0
Nuclear RNA decay	R-HSA-9930044	6.028843e-02	1.220	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	6.028843e-02	1.220	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	6.051487e-02	1.218	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	6.347176e-02	1.197	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	6.372644e-02	1.196	0	0
Frs2-mediated activation	R-HSA-170968	6.529779e-02	1.185	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	6.606589e-02	1.180	0	0
Myogenesis	R-HSA-525793	6.666269e-02	1.176	0	0
AURKA Activation by TPX2	R-HSA-8854518	6.755917e-02	1.170	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	6.831700e-02	1.165	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	7.058358e-02	1.151	0	0
Glycolysis	R-HSA-70171	7.187405e-02	1.143	0	0
Signaling by FGFR1 amplification mutants	R-HSA-1839120	7.273333e-02	1.138	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	7.273333e-02	1.138	0	0
Protein-protein interactions at synapses	R-HSA-6794362	7.307009e-02	1.136	0	0
Nuclear import of Rev protein	R-HSA-180746	7.409254e-02	1.130	0	0
Formation of annular gap junctions	R-HSA-196025	7.468324e-02	1.127	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	7.468324e-02	1.127	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	7.472229e-02	1.127	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	7.472229e-02	1.127	0	0
Regulation of TP53 Activity	R-HSA-5633007	7.534354e-02	1.123	0	0
Influenza Infection	R-HSA-168255	7.749216e-02	1.111	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	7.780856e-02	1.109	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	7.986335e-02	1.098	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	8.255633e-02	1.083	0	0
Basigin interactions	R-HSA-210991	8.255633e-02	1.083	0	0
HIV elongation arrest and recovery	R-HSA-167287	8.331102e-02	1.079	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	8.331102e-02	1.079	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	8.435172e-02	1.074	0	0
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	8.435172e-02	1.074	0	0
HCMV Infection	R-HSA-9609646	8.671218e-02	1.062	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	8.687379e-02	1.061	0	0
Post NMDA receptor activation events	R-HSA-438064	8.786408e-02	1.056	1	0
Neurexins and neuroligins	R-HSA-6794361	8.807606e-02	1.055	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	8.926592e-02	1.049	0	0
DCC mediated attractive signaling	R-HSA-418885	8.926592e-02	1.049	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	8.926592e-02	1.049	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	8.985455e-02	1.046	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	9.109672e-02	1.040	0	0
Gap junction degradation	R-HSA-190873	9.109672e-02	1.040	0	0
ALK mutants bind TKIs	R-HSA-9700645	9.109672e-02	1.040	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	9.311569e-02	1.031	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	9.311569e-02	1.031	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	9.311569e-02	1.031	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	9.900836e-02	1.004	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	9.900836e-02	1.004	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	9.900836e-02	1.004	0	0
Signaling by MAP2K mutants	R-HSA-9652169	9.900836e-02	1.004	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	1.088554e-01	0.963	0	0
PI3K/AKT activation	R-HSA-198203	1.088554e-01	0.963	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	1.168367e-01	0.932	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.168367e-01	0.932	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	1.020491e-01	0.991	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	1.121785e-01	0.950	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	1.121785e-01	0.950	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	9.800027e-02	1.009	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.256466e-01	0.901	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.022433e-01	0.990	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.022433e-01	0.990	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.080431e-01	0.966	0	0
Centrosome maturation	R-HSA-380287	1.217380e-01	0.915	0	0
Nucleotide Excision Repair	R-HSA-5696398	9.982282e-02	1.001	0	0
HIV Transcription Elongation	R-HSA-167169	1.256466e-01	0.901	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.256466e-01	0.901	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	9.444437e-02	1.025	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	1.088554e-01	0.963	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.160280e-01	0.935	0	0
HIV Life Cycle	R-HSA-162587	1.006253e-01	0.997	0	0
Signaling by WNT in cancer	R-HSA-4791275	1.227974e-01	0.911	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	1.191848e-01	0.924	0	0
S Phase	R-HSA-69242	1.039378e-01	0.983	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	1.256466e-01	0.901	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	1.256466e-01	0.901	0	0
RAF/MAP kinase cascade	R-HSA-5673001	1.147454e-01	0.940	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	1.256466e-01	0.901	0	0
Smooth Muscle Contraction	R-HSA-445355	9.496525e-02	1.022	0	0
tRNA processing in the nucleus	R-HSA-6784531	9.554487e-02	1.020	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	1.043401e-01	0.982	0	0
Developmental Biology	R-HSA-1266738	1.117028e-01	0.952	1	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	1.174492e-01	0.930	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	1.160280e-01	0.935	0	0
Activation of BH3-only proteins	R-HSA-114452	1.020491e-01	0.991	0	0
MITF-M-dependent gene expression	R-HSA-9856651	1.129890e-01	0.947	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.174492e-01	0.930	0	0
Interleukin-37 signaling	R-HSA-9008059	1.020491e-01	0.991	0	0
IRS activation	R-HSA-74713	1.274499e-01	0.895	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	1.274499e-01	0.895	0	0
Pyrophosphate hydrolysis	R-HSA-71737	1.274499e-01	0.895	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	1.278242e-01	0.893	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.286322e-01	0.891	0	0
Neurodegenerative Diseases	R-HSA-8863678	1.286322e-01	0.891	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	1.316913e-01	0.880	1	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	1.318516e-01	0.880	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	1.318516e-01	0.880	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	1.318516e-01	0.880	0	0
Specification of primordial germ cells	R-HSA-9827857	1.318516e-01	0.880	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.338897e-01	0.873	1	1
IPs transport between nucleus and cytosol	R-HSA-1855170	1.338897e-01	0.873	0	0
FLT3 Signaling	R-HSA-9607240	1.356550e-01	0.868	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	1.358343e-01	0.867	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	1.376663e-01	0.861	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	1.396634e-01	0.855	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	1.396634e-01	0.855	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	1.398439e-01	0.854	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	1.398439e-01	0.854	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	1.403511e-01	0.853	0	0
Long-term potentiation	R-HSA-9620244	1.416647e-01	0.849	0	0
Interleukin-7 signaling	R-HSA-1266695	1.416647e-01	0.849	0	0
SARS-CoV-1 Infection	R-HSA-9678108	1.425742e-01	0.846	0	0
Metabolism of non-coding RNA	R-HSA-194441	1.425786e-01	0.846	0	0
snRNP Assembly	R-HSA-191859	1.425786e-01	0.846	0	0
PI3K Cascade	R-HSA-109704	1.448447e-01	0.839	0	0
Striated Muscle Contraction	R-HSA-390522	1.454376e-01	0.837	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	1.454376e-01	0.837	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	1.462010e-01	0.835	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	1.476110e-01	0.831	0	0
GAB1 signalosome	R-HSA-180292	1.476110e-01	0.831	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	1.476110e-01	0.831	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	1.476110e-01	0.831	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	1.476110e-01	0.831	0	0
Activation of RAC1	R-HSA-428540	1.478641e-01	0.830	0	0
HCMV Late Events	R-HSA-9610379	1.483464e-01	0.829	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	1.515177e-01	0.820	0	0
HIV Infection	R-HSA-162906	1.531608e-01	0.815	0	0
Peptide chain elongation	R-HSA-156902	1.547904e-01	0.810	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	1.567918e-01	0.805	0	0
Regulation of PAK-2p34 activity by PS-GAP/RHG10	R-HSA-211728	1.615928e-01	0.792	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.615928e-01	0.792	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.615928e-01	0.792	0	0
TICAM1 deficiency - HSE	R-HSA-5602566	1.615928e-01	0.792	0	0
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	1.615928e-01	0.792	0	0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	R-HSA-5619043	1.615928e-01	0.792	0	0
Defective Mismatch Repair Associated With MSH6	R-HSA-5632968	1.615928e-01	0.792	0	0
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	1.615928e-01	0.792	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	2.323223e-01	0.634	0	0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	R-HSA-5619054	2.323223e-01	0.634	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	2.323223e-01	0.634	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	2.323223e-01	0.634	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	2.323223e-01	0.634	0	0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	2.323223e-01	0.634	0	0
Defective GFPT1 causes CMSTA1	R-HSA-4085023	2.323223e-01	0.634	0	0
Defective SLC6A2 causes orthostatic intolerance (OI)	R-HSA-5619109	2.323223e-01	0.634	0	0
TRAF3 deficiency - HSE	R-HSA-5602571	2.323223e-01	0.634	0	0
CLEC7A/inflammasome pathway	R-HSA-5660668	1.575060e-01	0.803	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	1.575060e-01	0.803	0	0
PKB-mediated events	R-HSA-109703	1.575060e-01	0.803	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	1.575060e-01	0.803	0	0
PDE3B signalling	R-HSA-165160	1.575060e-01	0.803	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	1.575060e-01	0.803	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	1.887025e-01	0.724	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	2.206335e-01	0.656	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	2.206335e-01	0.656	0	0
SOS-mediated signalling	R-HSA-112412	2.206335e-01	0.656	0	0
Recycling of eIF2:GDP	R-HSA-72731	2.206335e-01	0.656	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	2.206335e-01	0.656	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	1.688343e-01	0.773	0	0
Formation of axial mesoderm	R-HSA-9796292	1.905957e-01	0.720	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.987350e-01	0.702	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.987350e-01	0.702	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	1.987350e-01	0.702	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.693345e-01	0.771	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	1.839016e-01	0.735	0	0
Formation of the Early Elongation Complex	R-HSA-113418	1.839016e-01	0.735	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	1.698190e-01	0.770	0	0
Late endosomal microautophagy	R-HSA-9615710	1.989072e-01	0.701	0	0
FGFR2 alternative splicing	R-HSA-6803529	2.353728e-01	0.628	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.143126e-01	0.669	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	1.750249e-01	0.757	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	2.154699e-01	0.667	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	1.867849e-01	0.729	0	0
MET promotes cell motility	R-HSA-8875878	2.092626e-01	0.679	0	0
IRS-mediated signalling	R-HSA-112399	2.191362e-01	0.659	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.704167e-01	0.768	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	2.092626e-01	0.679	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.957645e-01	0.708	0	0
Co-inhibition by CTLA4	R-HSA-389513	1.811170e-01	0.742	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.077324e-01	0.682	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	1.910809e-01	0.719	0	0
Cellular response to starvation	R-HSA-9711097	2.171823e-01	0.663	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	1.574212e-01	0.803	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.575060e-01	0.803	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	2.130125e-01	0.672	0	0
PTEN Regulation	R-HSA-6807070	2.216571e-01	0.654	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.599550e-01	0.796	0	0
Eukaryotic Translation Elongation	R-HSA-156842	1.952349e-01	0.709	0	0
rRNA processing	R-HSA-72312	2.350894e-01	0.629	0	0
TNF signaling	R-HSA-75893	2.077324e-01	0.682	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.323223e-01	0.634	0	0
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.323223e-01	0.634	0	0
Defective Mismatch Repair Associated With MSH2	R-HSA-5632928	2.323223e-01	0.634	0	0
Regulation of PTEN localization	R-HSA-8948747	2.206335e-01	0.656	0	0
TBC/RABGAPs	R-HSA-8854214	1.678926e-01	0.775	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	2.126387e-01	0.672	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.740710e-01	0.759	0	0
Co-inhibition by PD-1	R-HSA-389948	1.666644e-01	0.778	0	0
UCH proteinases	R-HSA-5689603	2.120310e-01	0.674	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	2.154699e-01	0.667	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	1.811170e-01	0.742	0	0
MAPK family signaling cascades	R-HSA-5683057	1.779703e-01	0.750	0	0
Nef and signal transduction	R-HSA-164944	1.887025e-01	0.724	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	2.031344e-01	0.692	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	2.206426e-01	0.656	0	0
Regulation of KIT signaling	R-HSA-1433559	2.130125e-01	0.672	0	0
Maturation of nucleoprotein	R-HSA-9683610	1.905957e-01	0.720	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	1.905957e-01	0.720	0	0
DARPP-32 events	R-HSA-180024	1.989072e-01	0.701	0	0
Signal regulatory protein family interactions	R-HSA-391160	2.130125e-01	0.672	0	0
Glucose metabolism	R-HSA-70326	1.875201e-01	0.727	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	1.780205e-01	0.750	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	2.353728e-01	0.628	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	2.206335e-01	0.656	0	0
Trafficking of AMPA receptors	R-HSA-399719	2.300782e-01	0.638	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	1.578651e-01	0.802	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.910809e-01	0.719	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	1.693345e-01	0.771	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	1.575060e-01	0.803	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	2.092626e-01	0.679	0	0
Signaling by PDGFR in disease	R-HSA-9671555	2.168422e-01	0.664	0	0
Regulation of gene expression in beta cells	R-HSA-210745	1.989072e-01	0.701	0	0
SARS-CoV-2 Infection	R-HSA-9694516	1.864649e-01	0.729	0	0
Signaling by Interleukins	R-HSA-449147	2.226741e-01	0.652	1	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	1.905957e-01	0.720	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	2.359538e-01	0.627	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	2.359538e-01	0.627	0	0
Protein methylation	R-HSA-8876725	2.359538e-01	0.627	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.359538e-01	0.627	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	2.371792e-01	0.625	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.414319e-01	0.617	0	0
Sensory processing of sound	R-HSA-9659379	2.425212e-01	0.615	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	2.461640e-01	0.609	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	2.461640e-01	0.609	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	2.470026e-01	0.607	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	2.492895e-01	0.603	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	2.515437e-01	0.599	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	2.515437e-01	0.599	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	2.518966e-01	0.599	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	2.529534e-01	0.597	0	0
MET receptor recycling	R-HSA-8875656	2.529534e-01	0.597	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	2.529534e-01	0.597	0	0
FGFR1b ligand binding and activation	R-HSA-190370	2.529534e-01	0.597	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	2.529534e-01	0.597	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	2.529534e-01	0.597	0	0
Regulation of RAS by GAPs	R-HSA-5658442	2.539769e-01	0.595	0	0
Syndecan interactions	R-HSA-3000170	2.542613e-01	0.595	0	0
Growth hormone receptor signaling	R-HSA-982772	2.542613e-01	0.595	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	2.592945e-01	0.586	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	2.592945e-01	0.586	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	2.592945e-01	0.586	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.592945e-01	0.586	0	0
Regulation of necroptotic cell death	R-HSA-5675482	2.625297e-01	0.581	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	2.625297e-01	0.581	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	2.625297e-01	0.581	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.636946e-01	0.579	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	2.661422e-01	0.575	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	2.661422e-01	0.575	0	0
Generic Transcription Pathway	R-HSA-212436	2.665669e-01	0.574	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	2.668712e-01	0.574	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	2.668712e-01	0.574	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	2.715388e-01	0.566	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	2.734437e-01	0.563	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	2.734437e-01	0.563	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	2.734437e-01	0.563	0	0
Stimulation of the cell death response by PAK-2p34	R-HSA-211736	2.970888e-01	0.527	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	2.970888e-01	0.527	0	0
Potassium transport channels	R-HSA-1296067	2.970888e-01	0.527	0	0
Defective DHDDS causes RP59	R-HSA-4755609	2.970888e-01	0.527	0	0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	R-HSA-5619089	2.970888e-01	0.527	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	3.563946e-01	0.448	0	0
Axonal growth stimulation	R-HSA-209563	3.563946e-01	0.448	0	0
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	3.563946e-01	0.448	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.563946e-01	0.448	0	0
MET activates PTPN11	R-HSA-8865999	3.563946e-01	0.448	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.563946e-01	0.448	0	0
Defective HPRT1 disrupts guanine and hypoxanthine salvage	R-HSA-9734281	3.563946e-01	0.448	0	0
ARMS-mediated activation	R-HSA-170984	2.853697e-01	0.545	0	0
Lipophagy	R-HSA-9613354	2.853697e-01	0.545	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.107000e-01	0.386	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	4.107000e-01	0.386	0	0
Binding and entry of HIV virion	R-HSA-173107	3.176362e-01	0.498	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	3.495478e-01	0.456	0	0
SMAC (DIABLO) binds to IAPs	R-HSA-111463	4.604262e-01	0.337	0	0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	R-HSA-111464	4.604262e-01	0.337	0	0
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	4.604262e-01	0.337	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	4.604262e-01	0.337	0	0
Loss of phosphorylation of MECP2 at T308	R-HSA-9022535	4.604262e-01	0.337	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	4.604262e-01	0.337	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	4.604262e-01	0.337	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	3.067105e-01	0.513	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	3.809347e-01	0.419	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	3.809347e-01	0.419	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	3.809347e-01	0.419	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	3.809347e-01	0.419	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	3.809347e-01	0.419	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	3.305728e-01	0.481	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	3.124413e-01	0.505	0	0
Regulation of signaling by CBL	R-HSA-912631	3.544095e-01	0.450	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	4.116585e-01	0.385	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	4.116585e-01	0.385	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	4.116585e-01	0.385	0	0
SMAC, XIAP-regulated apoptotic response	R-HSA-111469	5.059591e-01	0.296	0	0
Plus-strand DNA synthesis	R-HSA-164525	5.059591e-01	0.296	0	0
Activation of caspases through apoptosome-mediated cleavage	R-HSA-111459	5.059591e-01	0.296	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	5.059591e-01	0.296	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	5.059591e-01	0.296	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.059591e-01	0.296	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	5.059591e-01	0.296	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	5.059591e-01	0.296	0	0
Signaling by RNF43 mutants	R-HSA-5340588	5.059591e-01	0.296	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.059591e-01	0.296	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	2.959410e-01	0.529	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	3.321376e-01	0.479	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	3.321376e-01	0.479	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	3.716473e-01	0.430	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	3.913579e-01	0.407	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	4.706944e-01	0.327	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.476521e-01	0.261	0	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	5.476521e-01	0.261	0	0
Signaling by LTK in cancer	R-HSA-9842640	5.476521e-01	0.261	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	5.476521e-01	0.261	0	0
Erythropoietin activates STAT5	R-HSA-9027283	5.476521e-01	0.261	0	0
Autointegration results in viral DNA circles	R-HSA-177539	5.476521e-01	0.261	0	0
Uncoating of the HIV Virion	R-HSA-162585	5.476521e-01	0.261	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.476521e-01	0.261	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	4.478939e-01	0.349	0	0
Erythropoietin activates RAS	R-HSA-9027284	4.988510e-01	0.302	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	4.988510e-01	0.302	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	4.988510e-01	0.302	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	3.240547e-01	0.489	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	3.692478e-01	0.433	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	3.594341e-01	0.444	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.926109e-01	0.307	0	0
Deadenylation of mRNA	R-HSA-429947	4.926109e-01	0.307	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	5.260272e-01	0.279	0	0
Phosphorylation of the APC/C	R-HSA-176412	5.260272e-01	0.279	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	5.260272e-01	0.279	0	0
Viral mRNA Translation	R-HSA-192823	4.226981e-01	0.374	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	5.354572e-01	0.271	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	4.870311e-01	0.312	0	0
Transcription of the HIV genome	R-HSA-167172	5.045152e-01	0.297	0	0
Formation of definitive endoderm	R-HSA-9823730	3.781343e-01	0.422	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.067105e-01	0.513	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	3.781343e-01	0.422	0	0
Ribosome-associated quality control	R-HSA-9948299	4.993193e-01	0.302	0	0
Transcriptional regulation of testis differentiation	R-HSA-9690406	2.829169e-01	0.548	0	0
TGFBR3 expression	R-HSA-9839394	2.928572e-01	0.533	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	3.823802e-01	0.418	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	3.809347e-01	0.419	0	0
Aggrephagy	R-HSA-9646399	3.988544e-01	0.399	0	0
FGFR1 ligand binding and activation	R-HSA-190242	3.305728e-01	0.481	0	0
Developmental Cell Lineages	R-HSA-9734767	2.941423e-01	0.531	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	4.876936e-01	0.312	0	0
Signaling by FGFR1	R-HSA-5654736	4.950763e-01	0.305	0	0
Regulation of CDH11 function	R-HSA-9762292	3.176362e-01	0.498	0	0
POLB-Dependent Long Patch Base Excision Repair	R-HSA-110362	3.809347e-01	0.419	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.816347e-01	0.418	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	4.478939e-01	0.349	0	0
eNOS activation	R-HSA-203615	2.959410e-01	0.529	0	0
Mismatch Repair	R-HSA-5358508	3.305728e-01	0.481	0	0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	R-HSA-9931529	4.604262e-01	0.337	0	0
PKA activation	R-HSA-163615	3.305728e-01	0.481	0	0
Signaling by MST1	R-HSA-8852405	5.059591e-01	0.296	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	3.299971e-01	0.481	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	4.988510e-01	0.302	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	5.354572e-01	0.271	0	0
Integration of provirus	R-HSA-162592	3.809347e-01	0.419	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	4.109756e-01	0.386	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	3.124413e-01	0.505	0	0
Activation of AKT2	R-HSA-165158	4.604262e-01	0.337	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	4.604262e-01	0.337	0	0
PTK6 Down-Regulation	R-HSA-8849472	4.604262e-01	0.337	0	0
FGFR1c ligand binding and activation	R-HSA-190373	4.416078e-01	0.355	0	0
Hydrolysis of LPC	R-HSA-1483115	4.706944e-01	0.327	0	0
Hydrolysis of LPE	R-HSA-1483152	5.476521e-01	0.261	0	0
Metalloprotease DUBs	R-HSA-5689901	5.354572e-01	0.271	0	0
Hedgehog 'off' state	R-HSA-5610787	3.895313e-01	0.409	0	0
IGF1R signaling cascade	R-HSA-2428924	3.044638e-01	0.516	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	2.829169e-01	0.548	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	4.086971e-01	0.389	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	2.917942e-01	0.535	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	5.354572e-01	0.271	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	4.604262e-01	0.337	0	0
CRMPs in Sema3A signaling	R-HSA-399956	4.706944e-01	0.327	0	0
Eukaryotic Translation Termination	R-HSA-72764	3.348273e-01	0.475	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	4.497612e-01	0.347	0	0
Ca2+ pathway	R-HSA-4086398	2.887459e-01	0.539	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	3.124413e-01	0.505	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	2.770890e-01	0.557	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	3.172506e-01	0.499	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	5.476521e-01	0.261	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	4.926109e-01	0.307	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	3.416759e-01	0.466	0	0
Insulin receptor signalling cascade	R-HSA-74751	3.044638e-01	0.516	0	0
G0 and Early G1	R-HSA-1538133	4.304569e-01	0.366	0	0
Attachment and Entry	R-HSA-9694614	4.249431e-01	0.372	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.716473e-01	0.430	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	3.263218e-01	0.486	0	0
MTOR signalling	R-HSA-165159	2.809469e-01	0.551	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	4.800856e-01	0.319	0	0
Interleukin-33 signaling	R-HSA-9014843	2.970888e-01	0.527	0	0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	R-HSA-446343	2.970888e-01	0.527	0	0
MET interacts with TNS proteins	R-HSA-8875513	3.563946e-01	0.448	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	3.563946e-01	0.448	0	0
Disorders of Developmental Biology	R-HSA-9675151	2.829169e-01	0.548	0	0
Bicarbonate transporters	R-HSA-425381	3.495478e-01	0.456	0	0
Reelin signalling pathway	R-HSA-8866376	4.604262e-01	0.337	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	4.604262e-01	0.337	0	0
PKA activation in glucagon signalling	R-HSA-164378	3.305728e-01	0.481	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	3.544095e-01	0.450	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	5.059591e-01	0.296	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	2.809469e-01	0.551	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	3.518906e-01	0.454	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	3.263218e-01	0.486	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	5.476521e-01	0.261	0	0
Signaling by Insulin receptor	R-HSA-74752	2.922391e-01	0.534	0	0
mTORC1-mediated signalling	R-HSA-166208	4.478939e-01	0.349	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	5.260272e-01	0.279	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	5.315780e-01	0.274	0	0
Signaling by TGFB family members	R-HSA-9006936	4.026818e-01	0.395	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	3.652916e-01	0.437	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	4.497612e-01	0.347	0	0
Signaling by TGFBR3	R-HSA-9839373	3.416759e-01	0.466	0	0
Interferon gamma signaling	R-HSA-877300	3.028814e-01	0.519	0	0
Signaling by FGFR	R-HSA-190236	4.920631e-01	0.308	0	0
Signalling to ERKs	R-HSA-187687	3.129077e-01	0.505	0	0
DNA strand elongation	R-HSA-69190	4.304569e-01	0.366	0	0
Lagging Strand Synthesis	R-HSA-69186	4.016690e-01	0.396	0	0
Spry regulation of FGF signaling	R-HSA-1295596	4.988510e-01	0.302	0	0
Platelet degranulation	R-HSA-114608	3.733519e-01	0.428	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	3.756509e-01	0.425	0	0
Signal attenuation	R-HSA-74749	3.176362e-01	0.498	0	0
Rap1 signalling	R-HSA-392517	3.544095e-01	0.450	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	4.016690e-01	0.396	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	5.001055e-01	0.301	0	0
Netrin-1 signaling	R-HSA-373752	3.110642e-01	0.507	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	2.853697e-01	0.545	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	2.853697e-01	0.545	0	0
Pervasive developmental disorders	R-HSA-9005895	4.116585e-01	0.385	0	0
Disorders of Nervous System Development	R-HSA-9697154	4.116585e-01	0.385	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	4.116585e-01	0.385	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	2.842467e-01	0.546	1	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	3.643961e-01	0.438	0	0
Nectin/Necl trans heterodimerization	R-HSA-420597	4.604262e-01	0.337	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	2.791353e-01	0.554	0	0
Signaling by ERBB4	R-HSA-1236394	3.005290e-01	0.522	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	3.544095e-01	0.450	0	0
PERK regulates gene expression	R-HSA-381042	5.062568e-01	0.296	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	5.354572e-01	0.271	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	4.413008e-01	0.355	0	0
Host Interactions of HIV factors	R-HSA-162909	3.351378e-01	0.475	0	0
Muscle contraction	R-HSA-397014	3.133287e-01	0.504	0	0
Interleukin-1 family signaling	R-HSA-446652	5.328752e-01	0.273	0	0
GP1b-IX-V activation signalling	R-HSA-430116	2.853697e-01	0.545	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.853697e-01	0.545	0	0
NADE modulates death signalling	R-HSA-205025	4.107000e-01	0.386	0	0
Hydroxycarboxylic acid-binding receptors	R-HSA-3296197	4.604262e-01	0.337	0	0
Interleukin-36 pathway	R-HSA-9014826	4.604262e-01	0.337	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	3.809347e-01	0.419	0	0
Platelet sensitization by LDL	R-HSA-432142	3.305728e-01	0.481	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	2.791353e-01	0.554	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	5.059591e-01	0.296	0	0
Lactose synthesis	R-HSA-5653890	5.476521e-01	0.261	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	5.476521e-01	0.261	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	4.478939e-01	0.349	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	4.988510e-01	0.302	0	0
Negative regulation of FLT3	R-HSA-9706369	5.260272e-01	0.279	0	0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	R-HSA-434316	5.260272e-01	0.279	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	4.876936e-01	0.312	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	4.649608e-01	0.333	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	4.249431e-01	0.372	0	0
ISG15 antiviral mechanism	R-HSA-1169408	4.480826e-01	0.349	0	0
Interferon Signaling	R-HSA-913531	4.960520e-01	0.304	0	0
Ion homeostasis	R-HSA-5578775	4.950763e-01	0.305	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	4.500894e-01	0.347	0	0
Signaling by NTRKs	R-HSA-166520	2.999807e-01	0.523	1	0
Histamine receptors	R-HSA-390650	3.563946e-01	0.448	0	0
PECAM1 interactions	R-HSA-210990	3.495478e-01	0.456	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	5.476521e-01	0.261	0	0
Processive synthesis on the lagging strand	R-HSA-69183	4.988510e-01	0.302	0	0
Selenocysteine synthesis	R-HSA-2408557	4.005762e-01	0.397	0	0
Ovarian tumor domain proteases	R-HSA-5689896	5.424381e-01	0.266	0	0
G2/M Transition	R-HSA-69275	3.542901e-01	0.451	0	0
Viral Infection Pathways	R-HSA-9824446	2.874142e-01	0.541	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	5.315780e-01	0.274	0	0
Mitotic G2-G2/M phases	R-HSA-453274	3.701317e-01	0.432	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	3.176362e-01	0.498	0	0
Co-inhibition by BTLA	R-HSA-9927353	4.604262e-01	0.337	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	3.809347e-01	0.419	0	0
CREB phosphorylation	R-HSA-199920	5.476521e-01	0.261	1	1
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	4.704660e-01	0.327	0	0
Signaling by NOTCH	R-HSA-157118	2.846448e-01	0.546	0	0
Gluconeogenesis	R-HSA-70263	3.725686e-01	0.429	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.400406e-01	0.468	0	0
p75NTR signals via NF-kB	R-HSA-193639	4.988510e-01	0.302	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	4.497245e-01	0.347	0	0
FLT3 signaling in disease	R-HSA-9682385	5.245133e-01	0.280	0	0
Maturation of nucleoprotein	R-HSA-9694631	3.544095e-01	0.450	0	0
FasL/ CD95L signaling	R-HSA-75157	3.563946e-01	0.448	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	2.853697e-01	0.545	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	3.495478e-01	0.456	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	3.809347e-01	0.419	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	5.059591e-01	0.296	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	4.416078e-01	0.355	0	0
HDL clearance	R-HSA-8964011	5.476521e-01	0.261	0	0
Inositol phosphate metabolism	R-HSA-1483249	4.119740e-01	0.385	0	0
RMTs methylate histone arginines	R-HSA-3214858	3.110642e-01	0.507	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	2.949294e-01	0.530	1	0
Transcriptional Regulation by MECP2	R-HSA-8986944	3.877635e-01	0.411	0	0
TRAIL signaling	R-HSA-75158	5.059591e-01	0.296	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	3.518906e-01	0.454	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	4.416078e-01	0.355	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	3.495478e-01	0.456	0	0
PKR-mediated signaling	R-HSA-9833482	3.731449e-01	0.428	0	0
SARS-CoV Infections	R-HSA-9679506	5.058279e-01	0.296	0	0
TYSND1 cleaves peroxisomal proteins	R-HSA-9033500	5.059591e-01	0.296	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	5.142865e-01	0.289	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	2.853697e-01	0.545	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	3.640995e-01	0.439	0	0
Signaling by Leptin	R-HSA-2586552	3.176362e-01	0.498	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	4.416078e-01	0.355	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	4.416078e-01	0.355	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	4.706944e-01	0.327	0	0
Assembly of Viral Components at the Budding Site	R-HSA-168316	4.604262e-01	0.337	0	0
GPER1 signaling	R-HSA-9634597	5.482701e-01	0.261	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.521881e-01	0.258	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.521881e-01	0.258	0	0
Antigen processing: Ub, ATP-independent proteasomal degradation	R-HSA-9912633	5.521881e-01	0.258	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	5.521881e-01	0.258	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	5.521881e-01	0.258	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	5.521881e-01	0.258	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.521881e-01	0.258	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.521881e-01	0.258	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	5.521881e-01	0.258	0	0
Cristae formation	R-HSA-8949613	5.560929e-01	0.255	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	5.560929e-01	0.255	0	0
Adaptive Immune System	R-HSA-1280218	5.586671e-01	0.253	0	0
DNA Damage Bypass	R-HSA-73893	5.638243e-01	0.249	0	0
Degradation of CDH1	R-HSA-9766229	5.638243e-01	0.249	0	0
Aquaporin-mediated transport	R-HSA-445717	5.674974e-01	0.246	0	0
Autophagy	R-HSA-9612973	5.687592e-01	0.245	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	5.695895e-01	0.244	1	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	5.736022e-01	0.241	1	0
Insulin receptor recycling	R-HSA-77387	5.761690e-01	0.239	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	5.761690e-01	0.239	0	0
G1/S Transition	R-HSA-69206	5.769829e-01	0.239	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	5.772078e-01	0.239	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	5.773115e-01	0.239	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	5.773115e-01	0.239	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	5.773115e-01	0.239	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	5.773115e-01	0.239	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	5.773115e-01	0.239	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	5.773115e-01	0.239	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	5.773115e-01	0.239	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	5.773115e-01	0.239	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	5.773115e-01	0.239	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	5.813754e-01	0.236	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	5.858289e-01	0.232	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	5.858289e-01	0.232	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	5.858289e-01	0.232	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	5.858289e-01	0.232	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	5.858289e-01	0.232	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	5.858289e-01	0.232	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	5.858289e-01	0.232	0	0
VLDL clearance	R-HSA-8964046	5.858289e-01	0.232	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	5.858289e-01	0.232	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	5.858289e-01	0.232	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	5.858289e-01	0.232	0	0
CHL1 interactions	R-HSA-447041	5.858289e-01	0.232	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	5.888802e-01	0.230	0	0
Integration of energy metabolism	R-HSA-163685	5.895629e-01	0.229	0	0
Generation of second messenger molecules	R-HSA-202433	5.940169e-01	0.226	0	0
Signaling by Erythropoietin	R-HSA-9006335	5.956657e-01	0.225	0	0
mRNA Capping	R-HSA-72086	5.956657e-01	0.225	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	5.956657e-01	0.225	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	5.981137e-01	0.223	0	0
COPI-mediated anterograde transport	R-HSA-6807878	5.999601e-01	0.222	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	6.013862e-01	0.221	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	6.013862e-01	0.221	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.013862e-01	0.221	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	6.084321e-01	0.216	0	0
Ion transport by P-type ATPases	R-HSA-936837	6.084321e-01	0.216	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	6.087757e-01	0.216	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	6.104227e-01	0.214	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	6.104227e-01	0.214	0	0
Activation of the pre-replicative complex	R-HSA-68962	6.145678e-01	0.211	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	6.145678e-01	0.211	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	6.145678e-01	0.211	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	6.145678e-01	0.211	0	0
Reverse Transcription of HIV RNA	R-HSA-162589	6.207857e-01	0.207	0	0
Minus-strand DNA synthesis	R-HSA-164516	6.207857e-01	0.207	0	0
RSK activation	R-HSA-444257	6.207857e-01	0.207	1	1
Regulation by c-FLIP	R-HSA-3371378	6.207857e-01	0.207	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	6.207857e-01	0.207	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	6.207857e-01	0.207	0	0
Dimerization of procaspase-8	R-HSA-69416	6.207857e-01	0.207	0	0
phospho-PLA2 pathway	R-HSA-111995	6.207857e-01	0.207	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.207857e-01	0.207	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	6.207857e-01	0.207	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	6.207857e-01	0.207	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	6.207857e-01	0.207	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	6.207857e-01	0.207	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	6.207857e-01	0.207	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	6.207857e-01	0.207	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	6.207857e-01	0.207	0	0
Nucleotide salvage defects	R-HSA-9734207	6.207857e-01	0.207	0	0
Neurotransmitter uptake and metabolism In glial cells	R-HSA-112313	6.207857e-01	0.207	0	0
Astrocytic Glutamate-Glutamine Uptake And Metabolism	R-HSA-210455	6.207857e-01	0.207	0	0
TGFBR3 PTM regulation	R-HSA-9839383	6.207857e-01	0.207	0	0
Sodium/Proton exchangers	R-HSA-425986	6.207857e-01	0.207	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	6.207857e-01	0.207	0	0
Selective autophagy	R-HSA-9663891	6.211454e-01	0.207	0	0
Regulation of insulin secretion	R-HSA-422356	6.216727e-01	0.206	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	6.235291e-01	0.205	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	6.244102e-01	0.205	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	6.244102e-01	0.205	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.244102e-01	0.205	1	1
Germ layer formation at gastrulation	R-HSA-9754189	6.244102e-01	0.205	0	0
The NLRP3 inflammasome	R-HSA-844456	6.244102e-01	0.205	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	6.244102e-01	0.205	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	6.264133e-01	0.203	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	6.264133e-01	0.203	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	6.264133e-01	0.203	0	0
Translation of Structural Proteins	R-HSA-9683701	6.264133e-01	0.203	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	6.273829e-01	0.202	0	0
TCR signaling	R-HSA-202403	6.325842e-01	0.199	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	6.328643e-01	0.199	0	0
Macroautophagy	R-HSA-1632852	6.348657e-01	0.197	0	0
Signaling by NODAL	R-HSA-1181150	6.463894e-01	0.190	0	0
Acyl chain remodelling of PI	R-HSA-1482922	6.463894e-01	0.190	0	0
Protein hydroxylation	R-HSA-9629569	6.463894e-01	0.190	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.505479e-01	0.187	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	6.505479e-01	0.187	0	0
MAPK1 (ERK2) activation	R-HSA-112411	6.527940e-01	0.185	0	0
CASP8 activity is inhibited	R-HSA-5218900	6.527940e-01	0.185	0	0
p75NTR regulates axonogenesis	R-HSA-193697	6.527940e-01	0.185	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.527940e-01	0.185	0	0
Unwinding of DNA	R-HSA-176974	6.527940e-01	0.185	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	6.527940e-01	0.185	0	0
Regulation of signaling by NODAL	R-HSA-1433617	6.527940e-01	0.185	0	0
Calcineurin activates NFAT	R-HSA-2025928	6.527940e-01	0.185	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.527940e-01	0.185	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	6.527940e-01	0.185	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	6.527940e-01	0.185	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.527940e-01	0.185	0	0
Interleukin-1 processing	R-HSA-448706	6.527940e-01	0.185	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	6.527940e-01	0.185	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	6.527940e-01	0.185	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	6.527940e-01	0.185	0	0
Interleukin-1 signaling	R-HSA-9020702	6.530460e-01	0.185	0	0
Signaling by FGFR2	R-HSA-5654738	6.563646e-01	0.183	0	0
Regulated Necrosis	R-HSA-5218859	6.595104e-01	0.181	0	0
Cilium Assembly	R-HSA-5617833	6.622594e-01	0.179	0	0
PI Metabolism	R-HSA-1483255	6.631673e-01	0.178	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	6.643198e-01	0.178	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	6.673361e-01	0.176	0	0
G-protein activation	R-HSA-202040	6.673361e-01	0.176	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	6.673361e-01	0.176	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	6.673361e-01	0.176	0	0
ERK/MAPK targets	R-HSA-198753	6.673361e-01	0.176	1	1
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	6.673361e-01	0.176	0	0
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	6.676148e-01	0.175	0	0
Activation of ATR in response to replication stress	R-HSA-176187	6.676148e-01	0.175	0	0
MAPK3 (ERK1) activation	R-HSA-110056	6.821023e-01	0.166	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	6.821023e-01	0.166	0	0
Folding of actin by CCT/TriC	R-HSA-390450	6.821023e-01	0.166	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	6.821023e-01	0.166	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	6.821023e-01	0.166	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	6.821023e-01	0.166	0	0
2-LTR circle formation	R-HSA-164843	6.821023e-01	0.166	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	6.821023e-01	0.166	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	6.821023e-01	0.166	0	0
Tandem pore domain potassium channels	R-HSA-1296346	6.821023e-01	0.166	0	0
Regulation of the apoptosome activity	R-HSA-9627069	6.821023e-01	0.166	0	0
Josephin domain DUBs	R-HSA-5689877	6.821023e-01	0.166	0	0
Interleukin-27 signaling	R-HSA-9020956	6.821023e-01	0.166	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	6.821023e-01	0.166	0	0
Maturation of spike protein	R-HSA-9683686	6.821023e-01	0.166	0	0
Formation of apoptosome	R-HSA-111458	6.821023e-01	0.166	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	6.840640e-01	0.165	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	6.840640e-01	0.165	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	6.840640e-01	0.165	0	0
Miscellaneous transport and binding events	R-HSA-5223345	6.840640e-01	0.165	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	6.872680e-01	0.163	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	6.872680e-01	0.163	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	6.872680e-01	0.163	0	0
Assembly Of The HIV Virion	R-HSA-175474	6.872680e-01	0.163	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	6.872680e-01	0.163	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.899610e-01	0.161	0	0
Hedgehog 'on' state	R-HSA-5632684	6.949702e-01	0.158	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.949702e-01	0.158	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	6.998797e-01	0.155	0	0
Diseases of DNA repair	R-HSA-9675135	6.998797e-01	0.155	0	0
Dual Incision in GG-NER	R-HSA-5696400	6.998977e-01	0.155	0	0
Signal amplification	R-HSA-392518	6.998977e-01	0.155	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	6.998977e-01	0.155	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	7.018793e-01	0.154	1	0
Regulation of beta-cell development	R-HSA-186712	7.024440e-01	0.153	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	7.032146e-01	0.153	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	7.062070e-01	0.151	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	7.062070e-01	0.151	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.062070e-01	0.151	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	7.062070e-01	0.151	0	0
Cellular hexose transport	R-HSA-189200	7.062070e-01	0.151	0	0
LDL clearance	R-HSA-8964038	7.062070e-01	0.151	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	7.062070e-01	0.151	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.062070e-01	0.151	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.062070e-01	0.151	0	0
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	7.062265e-01	0.151	1	0
Neutrophil degranulation	R-HSA-6798695	7.087191e-01	0.150	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.089382e-01	0.149	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.089382e-01	0.149	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	7.089382e-01	0.149	0	0
LGI-ADAM interactions	R-HSA-5682910	7.089382e-01	0.149	0	0
vRNP Assembly	R-HSA-192905	7.089382e-01	0.149	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.089382e-01	0.149	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.089382e-01	0.149	0	0
Suppression of apoptosis	R-HSA-9635465	7.089382e-01	0.149	0	0
Interleukin-2 signaling	R-HSA-9020558	7.089382e-01	0.149	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	7.132498e-01	0.147	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	7.132498e-01	0.147	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	7.151201e-01	0.146	0	0
Regulation of Apoptosis	R-HSA-169911	7.151201e-01	0.146	0	0
Oncogene Induced Senescence	R-HSA-2559585	7.151201e-01	0.146	0	0
Switching of origins to a post-replicative state	R-HSA-69052	7.171973e-01	0.144	0	0
Synthesis of DNA	R-HSA-69239	7.201367e-01	0.143	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	7.241788e-01	0.140	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	7.241788e-01	0.140	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.241788e-01	0.140	0	0
Interleukin receptor SHC signaling	R-HSA-912526	7.241788e-01	0.140	0	0
Synthesis of UDP-N-acetyl-glucosamine	R-HSA-446210	7.241788e-01	0.140	0	0
Free fatty acids regulate insulin secretion	R-HSA-400451	7.241788e-01	0.140	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	7.247456e-01	0.140	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	7.261293e-01	0.139	0	0
MAP kinase activation	R-HSA-450294	7.261293e-01	0.139	1	0
NGF-stimulated transcription	R-HSA-9031628	7.261778e-01	0.139	0	0
Signaling by NOTCH4	R-HSA-9013694	7.278817e-01	0.138	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	7.289846e-01	0.137	1	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	7.297378e-01	0.137	0	0
RNA Polymerase III Transcription	R-HSA-74158	7.297378e-01	0.137	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	7.297378e-01	0.137	0	0
RET signaling	R-HSA-8853659	7.297378e-01	0.137	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	7.297378e-01	0.137	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	7.306351e-01	0.136	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	7.335102e-01	0.135	0	0
Endosomal/Vacuolar pathway	R-HSA-1236977	7.335102e-01	0.135	0	0
NF-kB is activated and signals survival	R-HSA-209560	7.335102e-01	0.135	0	0
Plasmalogen biosynthesis	R-HSA-75896	7.335102e-01	0.135	0	0
ERKs are inactivated	R-HSA-202670	7.335102e-01	0.135	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	7.335102e-01	0.135	0	0
Viral RNP Complexes in the Host Cell Nucleus	R-HSA-168330	7.335102e-01	0.135	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	7.335102e-01	0.135	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	7.346467e-01	0.134	0	0
Heme signaling	R-HSA-9707616	7.374509e-01	0.132	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	7.374509e-01	0.132	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	7.376439e-01	0.132	1	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.386662e-01	0.132	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.386662e-01	0.132	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	7.412117e-01	0.130	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	7.412117e-01	0.130	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	7.412117e-01	0.130	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	7.429789e-01	0.129	1	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	7.429789e-01	0.129	1	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	7.429789e-01	0.129	1	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	7.437592e-01	0.129	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	7.461139e-01	0.127	1	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	7.461139e-01	0.127	1	0
G1/S DNA Damage Checkpoints	R-HSA-69615	7.484263e-01	0.126	0	0
Azathioprine ADME	R-HSA-9748787	7.507184e-01	0.125	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	7.507184e-01	0.125	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	7.560091e-01	0.121	0	0
Scavenging by Class F Receptors	R-HSA-3000484	7.560091e-01	0.121	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	7.560091e-01	0.121	0	0
Leading Strand Synthesis	R-HSA-69109	7.560091e-01	0.121	0	0
Polymerase switching	R-HSA-69091	7.560091e-01	0.121	0	0
Repression of WNT target genes	R-HSA-4641265	7.560091e-01	0.121	0	0
GRB2 events in EGFR signaling	R-HSA-179812	7.560091e-01	0.121	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.560091e-01	0.121	0	0
VLDLR internalisation and degradation	R-HSA-8866427	7.560091e-01	0.121	0	0
Signaling by LTK	R-HSA-9842663	7.560091e-01	0.121	0	0
p75NTR recruits signalling complexes	R-HSA-209543	7.560091e-01	0.121	0	0
Interleukin-35 Signalling	R-HSA-8984722	7.560091e-01	0.121	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.560091e-01	0.121	0	0
OAS antiviral response	R-HSA-8983711	7.560091e-01	0.121	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	7.571943e-01	0.121	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	7.573361e-01	0.121	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	7.573361e-01	0.121	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	7.573361e-01	0.121	0	0
G protein gated Potassium channels	R-HSA-1296059	7.573361e-01	0.121	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	7.573361e-01	0.121	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	7.573361e-01	0.121	0	0
Tight junction interactions	R-HSA-420029	7.573361e-01	0.121	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	7.573361e-01	0.121	0	0
Laminin interactions	R-HSA-3000157	7.573361e-01	0.121	0	0
HDMs demethylate histones	R-HSA-3214842	7.573361e-01	0.121	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	7.592984e-01	0.120	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	7.623391e-01	0.118	0	0
PCP/CE pathway	R-HSA-4086400	7.677555e-01	0.115	0	0
Stabilization of p53	R-HSA-69541	7.700546e-01	0.113	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	7.700546e-01	0.113	0	0
Plasma lipoprotein clearance	R-HSA-8964043	7.700546e-01	0.113	0	0
Signaling by ALK	R-HSA-201556	7.700546e-01	0.113	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	7.700546e-01	0.113	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	7.703852e-01	0.113	1	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	7.725838e-01	0.112	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	7.725838e-01	0.112	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	7.725838e-01	0.112	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	7.725838e-01	0.112	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	7.725838e-01	0.112	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	7.735339e-01	0.112	0	0
Orc1 removal from chromatin	R-HSA-68949	7.735339e-01	0.112	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	7.735339e-01	0.112	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	7.766098e-01	0.110	0	0
Processing of SMDT1	R-HSA-8949664	7.766098e-01	0.110	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	7.766098e-01	0.110	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	7.766098e-01	0.110	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	7.766098e-01	0.110	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	7.766098e-01	0.110	0	0
Diseases of nucleotide metabolism	R-HSA-9735804	7.766098e-01	0.110	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	7.766098e-01	0.110	0	0
Acyl chain remodeling of DAG and TAG	R-HSA-1482883	7.766098e-01	0.110	0	0
Interleukin-6 signaling	R-HSA-1059683	7.766098e-01	0.110	0	0
Hemostasis	R-HSA-109582	7.814662e-01	0.107	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.823526e-01	0.107	0	0
Diseases of Immune System	R-HSA-5260271	7.823526e-01	0.107	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	7.823526e-01	0.107	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	7.823526e-01	0.107	0	0
Interleukin-2 family signaling	R-HSA-451927	7.823526e-01	0.107	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	7.842119e-01	0.106	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	7.843092e-01	0.106	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	7.843092e-01	0.106	0	0
Amino acids regulate mTORC1	R-HSA-9639288	7.843092e-01	0.106	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	7.869880e-01	0.104	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	7.869880e-01	0.104	0	0
Insulin processing	R-HSA-264876	7.869880e-01	0.104	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	7.946720e-01	0.100	0	0
Retrograde neurotrophin signalling	R-HSA-177504	7.954722e-01	0.099	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	7.954722e-01	0.099	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	7.954722e-01	0.099	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	7.954722e-01	0.099	0	0
Removal of the Flap Intermediate	R-HSA-69166	7.954722e-01	0.099	0	0
cGMP effects	R-HSA-418457	7.954722e-01	0.099	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	7.954722e-01	0.099	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	7.954722e-01	0.099	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	7.954722e-01	0.099	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	7.954722e-01	0.099	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	7.954722e-01	0.099	0	0
Acyl chain remodeling of CL	R-HSA-1482798	7.954722e-01	0.099	0	0
Zinc transporters	R-HSA-435354	7.954722e-01	0.099	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.005824e-01	0.097	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.005824e-01	0.097	0	0
Inflammasomes	R-HSA-622312	8.005824e-01	0.097	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	8.011881e-01	0.096	0	0
Signaling by Hedgehog	R-HSA-5358351	8.018651e-01	0.096	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	8.046304e-01	0.094	0	0
Neuronal System	R-HSA-112316	8.048885e-01	0.094	1	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.053175e-01	0.094	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	8.053175e-01	0.094	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.127429e-01	0.090	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.127429e-01	0.090	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	8.127429e-01	0.090	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	8.127429e-01	0.090	0	0
Translesion synthesis by REV1	R-HSA-110312	8.127429e-01	0.090	0	0
Signaling by Activin	R-HSA-1502540	8.127429e-01	0.090	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	8.127429e-01	0.090	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	8.127429e-01	0.090	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	8.127429e-01	0.090	0	0
DNA Damage Reversal	R-HSA-73942	8.127429e-01	0.090	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	8.134010e-01	0.090	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	8.134010e-01	0.090	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.134010e-01	0.090	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.134010e-01	0.090	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	8.134010e-01	0.090	1	0
Glucagon-type ligand receptors	R-HSA-420092	8.134010e-01	0.090	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	8.141926e-01	0.089	0	0
Ion channel transport	R-HSA-983712	8.143890e-01	0.089	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	8.153546e-01	0.089	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	8.158116e-01	0.088	0	0
Interleukin-17 signaling	R-HSA-448424	8.158116e-01	0.088	1	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	8.160139e-01	0.088	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	8.254778e-01	0.083	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	8.254778e-01	0.083	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	8.254778e-01	0.083	0	0
Signaling by FGFR4	R-HSA-5654743	8.262069e-01	0.083	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	8.262069e-01	0.083	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	8.262069e-01	0.083	0	0
Signaling by SCF-KIT	R-HSA-1433557	8.262069e-01	0.083	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	8.267824e-01	0.083	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	8.268622e-01	0.083	1	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	8.268622e-01	0.083	1	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	8.285562e-01	0.082	0	0
Translesion synthesis by POLI	R-HSA-5656121	8.285562e-01	0.082	0	0
Entry of Influenza Virion into Host Cell via Endocytosis	R-HSA-168275	8.285562e-01	0.082	0	0
Induction of Cell-Cell Fusion	R-HSA-9733458	8.285562e-01	0.082	0	0
Attachment and Entry	R-HSA-9678110	8.285562e-01	0.082	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	8.285562e-01	0.082	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	8.285562e-01	0.082	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	8.285562e-01	0.082	0	0
Activation of SMO	R-HSA-5635838	8.285562e-01	0.082	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	8.285562e-01	0.082	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	8.285562e-01	0.082	0	0
Virus Assembly and Release	R-HSA-168268	8.285562e-01	0.082	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.304387e-01	0.081	0	0
Dual incision in TC-NER	R-HSA-6782135	8.321645e-01	0.080	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	8.359126e-01	0.078	0	0
G1 Phase	R-HSA-69236	8.359126e-01	0.078	0	0
Cyclin D associated events in G1	R-HSA-69231	8.359126e-01	0.078	0	0
Gap junction trafficking	R-HSA-190828	8.359126e-01	0.078	0	0
Budding and maturation of HIV virion	R-HSA-162588	8.368466e-01	0.077	0	0
Downstream signal transduction	R-HSA-186763	8.368466e-01	0.077	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	8.405931e-01	0.075	0	0
Extension of Telomeres	R-HSA-180786	8.405931e-01	0.075	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	8.405931e-01	0.075	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	8.405931e-01	0.075	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	8.418191e-01	0.075	0	0
Translesion synthesis by POLK	R-HSA-5655862	8.430350e-01	0.074	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	8.430350e-01	0.074	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	8.430350e-01	0.074	0	0
Passive transport by Aquaporins	R-HSA-432047	8.430350e-01	0.074	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	8.430350e-01	0.074	0	0
Coenzyme A biosynthesis	R-HSA-196783	8.430350e-01	0.074	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	8.450558e-01	0.073	1	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	8.450558e-01	0.073	1	0
Asymmetric localization of PCP proteins	R-HSA-4608870	8.451473e-01	0.073	0	0
Signaling by FGFR3	R-HSA-5654741	8.451473e-01	0.073	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	8.451473e-01	0.073	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.451473e-01	0.073	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.451473e-01	0.073	0	0
HS-GAG degradation	R-HSA-2024096	8.475410e-01	0.072	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	8.475410e-01	0.072	0	0
Chaperonin-mediated protein folding	R-HSA-390466	8.481238e-01	0.072	0	0
Pyruvate metabolism	R-HSA-70268	8.481238e-01	0.072	0	0
tRNA Aminoacylation	R-HSA-379724	8.486632e-01	0.071	0	0
FOXO-mediated transcription	R-HSA-9614085	8.501968e-01	0.070	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	8.539273e-01	0.069	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	8.539273e-01	0.069	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.544535e-01	0.068	0	0
Transmission across Chemical Synapses	R-HSA-112315	8.548578e-01	0.068	1	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	8.562918e-01	0.067	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.562918e-01	0.067	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	8.562918e-01	0.067	0	0
Catecholamine biosynthesis	R-HSA-209905	8.562918e-01	0.067	0	0
Choline catabolism	R-HSA-6798163	8.562918e-01	0.067	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	8.575936e-01	0.067	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	8.575936e-01	0.067	0	0
Diseases associated with glycosylation precursor biosynthesis	R-HSA-5609975	8.575936e-01	0.067	0	0
Cardiogenesis	R-HSA-9733709	8.575936e-01	0.067	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	8.636147e-01	0.064	1	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.637688e-01	0.064	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	8.637688e-01	0.064	0	0
Acyl chain remodelling of PC	R-HSA-1482788	8.670365e-01	0.062	0	0
Vpu mediated degradation of CD4	R-HSA-180534	8.670365e-01	0.062	0	0
Translation of Structural Proteins	R-HSA-9694635	8.678991e-01	0.062	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	8.684297e-01	0.061	0	0
Apoptotic factor-mediated response	R-HSA-111471	8.684297e-01	0.061	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	8.684297e-01	0.061	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	8.684297e-01	0.061	0	0
Metal ion SLC transporters	R-HSA-425410	8.701894e-01	0.060	0	0
Potential therapeutics for SARS	R-HSA-9679191	8.730064e-01	0.059	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	8.759011e-01	0.058	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	8.759011e-01	0.058	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.759011e-01	0.058	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	8.759011e-01	0.058	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	8.759011e-01	0.058	0	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.759011e-01	0.058	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	8.759011e-01	0.058	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	8.759011e-01	0.058	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	8.759011e-01	0.058	0	0
Selenoamino acid metabolism	R-HSA-2408522	8.762752e-01	0.057	0	0
Gap junction trafficking and regulation	R-HSA-157858	8.777044e-01	0.057	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	8.795431e-01	0.056	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	8.795431e-01	0.056	0	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	8.795431e-01	0.056	0	0
Translesion Synthesis by POLH	R-HSA-110320	8.795431e-01	0.056	0	0
Pyrimidine biosynthesis	R-HSA-500753	8.795431e-01	0.056	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	8.795431e-01	0.056	0	0
Strand-asynchronous mitochondrial DNA replication	R-HSA-9913635	8.795431e-01	0.056	0	0
Other interleukin signaling	R-HSA-449836	8.795431e-01	0.056	0	0
STING mediated induction of host immune responses	R-HSA-1834941	8.795431e-01	0.056	0	0
Cellular response to chemical stress	R-HSA-9711123	8.836177e-01	0.054	0	0
RSV-host interactions	R-HSA-9833110	8.841216e-01	0.053	0	0
Acyl chain remodelling of PE	R-HSA-1482839	8.842175e-01	0.053	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	8.842175e-01	0.053	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	8.842175e-01	0.053	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	8.842175e-01	0.053	0	0
Transferrin endocytosis and recycling	R-HSA-917977	8.842175e-01	0.053	0	0
Protein folding	R-HSA-391251	8.843671e-01	0.053	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	8.843671e-01	0.053	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	8.865584e-01	0.052	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	8.897183e-01	0.051	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	8.897183e-01	0.051	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	8.897183e-01	0.051	0	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	8.897183e-01	0.051	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	8.897183e-01	0.051	0	0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	8.897183e-01	0.051	0	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	8.897183e-01	0.051	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	8.897183e-01	0.051	0	0
Wax and plasmalogen biosynthesis	R-HSA-8848584	8.897183e-01	0.051	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.897183e-01	0.051	0	0
The phototransduction cascade	R-HSA-2514856	8.915834e-01	0.050	0	0
HS-GAG biosynthesis	R-HSA-2022928	8.920152e-01	0.050	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	8.920152e-01	0.050	0	0
GPVI-mediated activation cascade	R-HSA-114604	8.920152e-01	0.050	0	0
RUNX2 regulates bone development	R-HSA-8941326	8.920152e-01	0.050	0	0
G1/S-Specific Transcription	R-HSA-69205	8.920152e-01	0.050	0	0
Immune System	R-HSA-168256	8.924416e-01	0.049	1	0
Platelet homeostasis	R-HSA-418346	8.938983e-01	0.049	0	0
Collagen formation	R-HSA-1474290	8.946997e-01	0.048	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	8.959809e-01	0.048	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	8.979791e-01	0.047	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	8.990346e-01	0.046	0	0
Matriglycan biosynthesis on DAG1	R-HSA-9939291	8.990346e-01	0.046	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.990346e-01	0.046	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	8.990346e-01	0.046	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	8.990346e-01	0.046	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	8.990346e-01	0.046	0	0
Vitamin C (ascorbate) metabolism	R-HSA-196836	8.990346e-01	0.046	0	0
Acyl chain remodelling of PG	R-HSA-1482925	8.990346e-01	0.046	0	0
Adipogenesis	R-HSA-9843745	8.991593e-01	0.046	0	0
Degradation of DVL	R-HSA-4641258	8.993223e-01	0.046	0	0
Degradation of AXIN	R-HSA-4641257	8.993223e-01	0.046	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	8.995636e-01	0.046	0	0
Stimuli-sensing channels	R-HSA-2672351	9.029689e-01	0.044	0	0
Circadian clock	R-HSA-9909396	9.031826e-01	0.044	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.040330e-01	0.044	0	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	9.061662e-01	0.043	0	0
Purine salvage	R-HSA-74217	9.061662e-01	0.043	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	9.061662e-01	0.043	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.075644e-01	0.042	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	9.075644e-01	0.042	0	0
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.075644e-01	0.042	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	9.075644e-01	0.042	0	0
Translation	R-HSA-72766	9.090440e-01	0.041	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.125728e-01	0.040	0	0
G alpha (z) signalling events	R-HSA-418597	9.151754e-01	0.038	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	9.151754e-01	0.038	0	0
Signaling by NOTCH3	R-HSA-9012852	9.151754e-01	0.038	0	0
Notch-HLH transcription pathway	R-HSA-350054	9.153740e-01	0.038	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	9.153740e-01	0.038	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	9.153740e-01	0.038	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.153740e-01	0.038	0	0
Regulation of mitotic cell cycle	R-HSA-453276	9.167234e-01	0.038	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	9.167234e-01	0.038	0	0
Formation of the cornified envelope	R-HSA-6809371	9.181835e-01	0.037	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	9.185672e-01	0.037	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	9.185672e-01	0.037	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	9.185672e-01	0.037	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.185672e-01	0.037	0	0
Disease	R-HSA-1643685	9.188505e-01	0.037	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.202930e-01	0.036	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.225243e-01	0.035	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	9.225243e-01	0.035	0	0
Biosynthesis of maresins	R-HSA-9018682	9.225243e-01	0.035	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	9.225243e-01	0.035	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	9.241733e-01	0.034	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.241733e-01	0.034	0	0
Maturation of spike protein	R-HSA-9694548	9.241733e-01	0.034	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.241733e-01	0.034	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.241733e-01	0.034	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.241733e-01	0.034	0	0
Toll-like Receptor Cascades	R-HSA-168898	9.267231e-01	0.033	1	0
CYP2E1 reactions	R-HSA-211999	9.290707e-01	0.032	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.290707e-01	0.032	0	0
Synthesis of dolichyl-phosphate	R-HSA-446199	9.290707e-01	0.032	0	0
Complex III assembly	R-HSA-9865881	9.290707e-01	0.032	0	0
Mitochondrial RNA degradation	R-HSA-9836573	9.290707e-01	0.032	0	0
Interleukin-6 family signaling	R-HSA-6783589	9.290707e-01	0.032	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	9.294139e-01	0.032	0	0
HIV Transcription Initiation	R-HSA-167161	9.294139e-01	0.032	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	9.294139e-01	0.032	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	9.294139e-01	0.032	0	0
SLC transporter disorders	R-HSA-5619102	9.334429e-01	0.030	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	9.343107e-01	0.030	0	0
Activation of GABAB receptors	R-HSA-991365	9.343107e-01	0.030	0	0
GABA B receptor activation	R-HSA-977444	9.343107e-01	0.030	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	9.350644e-01	0.029	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	9.350644e-01	0.029	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	9.350644e-01	0.029	0	0
Acyl chain remodelling of PS	R-HSA-1482801	9.350644e-01	0.029	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.350644e-01	0.029	0	0
Hyaluronan degradation	R-HSA-2160916	9.350644e-01	0.029	0	0
Downstream TCR signaling	R-HSA-202424	9.355461e-01	0.029	0	0
Signaling by NOTCH1	R-HSA-1980143	9.374071e-01	0.028	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.380592e-01	0.028	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	9.388843e-01	0.027	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.388843e-01	0.027	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.405520e-01	0.027	0	0
TRP channels	R-HSA-3295583	9.405520e-01	0.027	0	0
Urea cycle	R-HSA-70635	9.405520e-01	0.027	0	0
Sphingolipid catabolism	R-HSA-9845614	9.405520e-01	0.027	0	0
Mitochondrial biogenesis	R-HSA-1592230	9.418580e-01	0.026	0	0
Formation of paraxial mesoderm	R-HSA-9793380	9.418890e-01	0.026	0	0
Proteasome assembly	R-HSA-9907900	9.431545e-01	0.025	0	0
tRNA processing	R-HSA-72306	9.433821e-01	0.025	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.439177e-01	0.025	0	0
Cardiac conduction	R-HSA-5576891	9.454353e-01	0.024	0	0
Mitochondrial protein import	R-HSA-1268020	9.454982e-01	0.024	0	0
Signaling by PDGF	R-HSA-186797	9.454982e-01	0.024	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	9.455761e-01	0.024	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.455761e-01	0.024	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	9.455761e-01	0.024	0	0
Triglyceride biosynthesis	R-HSA-75109	9.455761e-01	0.024	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	9.456554e-01	0.024	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.471398e-01	0.024	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.471398e-01	0.024	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.471398e-01	0.024	0	0
Somitogenesis	R-HSA-9824272	9.471398e-01	0.024	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	9.474570e-01	0.023	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	9.488981e-01	0.023	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.501758e-01	0.022	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	9.501758e-01	0.022	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.501758e-01	0.022	0	0
Pyrimidine salvage	R-HSA-73614	9.501758e-01	0.022	0	0
Pyroptosis	R-HSA-5620971	9.501758e-01	0.022	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.508578e-01	0.022	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.508578e-01	0.022	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.508578e-01	0.022	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	9.521269e-01	0.021	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.533114e-01	0.021	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	9.543871e-01	0.020	0	0
Platelet calcium homeostasis	R-HSA-418360	9.543871e-01	0.020	0	0
Gastrulation	R-HSA-9758941	9.574247e-01	0.019	0	0
Intraflagellar transport	R-HSA-5620924	9.575579e-01	0.019	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	9.582426e-01	0.019	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.582426e-01	0.019	0	0
Neurotransmitter clearance	R-HSA-112311	9.582426e-01	0.019	0	0
Potassium Channels	R-HSA-1296071	9.583697e-01	0.018	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	9.605706e-01	0.017	0	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	9.606146e-01	0.017	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	9.606317e-01	0.017	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	9.617725e-01	0.017	0	0
Cargo concentration in the ER	R-HSA-5694530	9.617725e-01	0.017	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.617725e-01	0.017	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	9.617725e-01	0.017	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	9.617725e-01	0.017	0	0
Infectious disease	R-HSA-5663205	9.623734e-01	0.017	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.631216e-01	0.016	0	0
DAG1 glycosylations	R-HSA-8931838	9.650042e-01	0.015	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.659920e-01	0.015	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.659920e-01	0.015	0	0
Leishmania phagocytosis	R-HSA-9664417	9.660153e-01	0.015	0	0
Parasite infection	R-HSA-9664407	9.660153e-01	0.015	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.660153e-01	0.015	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.667578e-01	0.015	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.676917e-01	0.014	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	9.679628e-01	0.014	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.684263e-01	0.014	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.697709e-01	0.013	0	0
Retinoid metabolism and transport	R-HSA-975634	9.697709e-01	0.013	0	0
Metabolism of cofactors	R-HSA-8978934	9.697709e-01	0.013	0	0
Resolution of D-Loop Structures	R-HSA-5693537	9.706715e-01	0.013	0	0
Glutamate and glutamine metabolism	R-HSA-8964539	9.706715e-01	0.013	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.706715e-01	0.013	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.719778e-01	0.012	0	0
ER-Phagosome pathway	R-HSA-1236974	9.729242e-01	0.012	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	9.731270e-01	0.012	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.731513e-01	0.012	0	0
Mitophagy	R-HSA-5205647	9.731513e-01	0.012	0	0
Hyaluronan metabolism	R-HSA-2142845	9.731513e-01	0.012	0	0
Signaling by NOTCH2	R-HSA-1980145	9.731513e-01	0.012	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.731513e-01	0.012	0	0
Neurotransmitter release cycle	R-HSA-112310	9.745466e-01	0.011	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.745466e-01	0.011	0	0
Paracetamol ADME	R-HSA-9753281	9.747628e-01	0.011	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.752746e-01	0.011	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	9.754215e-01	0.011	0	0
Glycosphingolipid transport	R-HSA-9845576	9.775000e-01	0.010	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.775000e-01	0.010	0	0
Triglyceride catabolism	R-HSA-163560	9.775000e-01	0.010	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.794027e-01	0.009	0	0
Lysine catabolism	R-HSA-71064	9.794027e-01	0.009	0	0
Collagen chain trimerization	R-HSA-8948216	9.794027e-01	0.009	0	0
Metabolism of folate and pterines	R-HSA-196757	9.794027e-01	0.009	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.798614e-01	0.009	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.801664e-01	0.009	0	0
Leishmania infection	R-HSA-9658195	9.810797e-01	0.008	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.810797e-01	0.008	0	0
Elastic fibre formation	R-HSA-1566948	9.811447e-01	0.008	0	0
Integrin cell surface interactions	R-HSA-216083	9.811459e-01	0.008	0	0
Cholesterol biosynthesis	R-HSA-191273	9.811459e-01	0.008	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.813274e-01	0.008	0	0
Peroxisomal protein import	R-HSA-9033241	9.813274e-01	0.008	0	0
Triglyceride metabolism	R-HSA-8979227	9.813274e-01	0.008	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.813760e-01	0.008	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.823907e-01	0.008	0	0
GABA receptor activation	R-HSA-977443	9.826895e-01	0.008	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	9.826895e-01	0.008	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	9.826895e-01	0.008	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	9.826895e-01	0.008	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	9.826895e-01	0.008	0	0
Metabolism of polyamines	R-HSA-351202	9.826895e-01	0.008	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	9.826895e-01	0.008	0	0
Pentose phosphate pathway	R-HSA-71336	9.827394e-01	0.008	0	0
Nucleotide salvage	R-HSA-8956321	9.839550e-01	0.007	0	0
Glycogen metabolism	R-HSA-8982491	9.841994e-01	0.007	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.846486e-01	0.007	0	0
PPARA activates gene expression	R-HSA-1989781	9.847779e-01	0.007	0	0
G alpha (s) signalling events	R-HSA-418555	9.858526e-01	0.006	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.862814e-01	0.006	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.866274e-01	0.006	0	0
Intra-Golgi traffic	R-HSA-6811438	9.867595e-01	0.006	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.867595e-01	0.006	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.868205e-01	0.006	0	0
Cellular response to hypoxia	R-HSA-1234174	9.881753e-01	0.005	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.884684e-01	0.005	0	0
Neddylation	R-HSA-8951664	9.890373e-01	0.005	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.891433e-01	0.005	0	0
Amine ligand-binding receptors	R-HSA-375280	9.898438e-01	0.004	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.898756e-01	0.004	0	0
Fanconi Anemia Pathway	R-HSA-6783310	9.907031e-01	0.004	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.919522e-01	0.004	0	0
Extracellular matrix organization	R-HSA-1474244	9.919920e-01	0.003	0	0
ECM proteoglycans	R-HSA-3000178	9.925513e-01	0.003	0	0
Protein localization	R-HSA-9609507	9.929152e-01	0.003	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.931067e-01	0.003	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.933791e-01	0.003	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.934104e-01	0.003	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.934727e-01	0.003	0	0
Chemokine receptors bind chemokines	R-HSA-380108	9.934727e-01	0.003	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.938200e-01	0.003	0	0
Complex IV assembly	R-HSA-9864848	9.945309e-01	0.002	0	0
Iron uptake and transport	R-HSA-917937	9.945406e-01	0.002	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	9.945406e-01	0.002	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.953294e-01	0.002	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.955529e-01	0.002	0	0
ABC transporter disorders	R-HSA-5619084	9.956808e-01	0.002	0	0
Visual phototransduction	R-HSA-2187338	9.962931e-01	0.002	0	0
Metabolism of amine-derived hormones	R-HSA-209776	9.964858e-01	0.002	0	0
Synthesis of PA	R-HSA-1483166	9.967833e-01	0.001	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.970833e-01	0.001	0	0
RAB geranylgeranylation	R-HSA-8873719	9.975333e-01	0.001	0	0
Post-translational protein modification	R-HSA-597592	9.976147e-01	0.001	0	0
Collagen degradation	R-HSA-1442490	9.977422e-01	0.001	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.979163e-01	0.001	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.979163e-01	0.001	0	0
Complex I biogenesis	R-HSA-6799198	9.981085e-01	0.001	0	0
GPCR downstream signalling	R-HSA-388396	9.981827e-01	0.001	1	0
Xenobiotics	R-HSA-211981	9.982687e-01	0.001	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.982687e-01	0.001	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.984042e-01	0.001	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.985496e-01	0.001	0	0
Nicotinate metabolism	R-HSA-196807	9.986725e-01	0.001	0	0
G alpha (q) signalling events	R-HSA-416476	9.987044e-01	0.001	1	0
FCERI mediated MAPK activation	R-HSA-2871796	9.987496e-01	0.001	0	0
G alpha (i) signalling events	R-HSA-418594	9.989560e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.991829e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.992196e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.992249e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.992571e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.993041e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.993578e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.994496e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.995347e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.996158e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.996527e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.997055e-01	0.000	0	0
Signaling by GPCR	R-HSA-372790	9.997294e-01	0.000	1	0
Mitochondrial translation termination	R-HSA-5419276	9.997360e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.997566e-01	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	9.997597e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.997756e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.997781e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.997944e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.998624e-01	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	9.998907e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999070e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.999149e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.999221e-01	0.000	0	0
Post-translational protein phosphorylation	R-HSA-8957275	9.999348e-01	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	9.999647e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999668e-01	0.000	1	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999745e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999822e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999838e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999847e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999856e-01	0.000	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	9.999868e-01	0.000	0	0
Metabolism of proteins	R-HSA-392499	9.999868e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999873e-01	0.000	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.999890e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.999919e-01	0.000	0	0
Drug ADME	R-HSA-9748784	9.999931e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999945e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999951e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999955e-01	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	9.999976e-01	0.000	0	0
Transport of small molecules	R-HSA-382551	9.999980e-01	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	9.999986e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999988e-01	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.999994e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999994e-01	0.000	0	0
Complement cascade	R-HSA-166658	9.999995e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999995e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999995e-01	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	9.999996e-01	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	9.999997e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999997e-01	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	9.999997e-01	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.999999e-01	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0