GRK2

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
Download
substrate_uniprot site source substrate_genes site_seq
A0MZ66 S473 Sugiyama SHTN1 KIAA1598 LGtLNKSTSSRsLKsLDPENsEtELERILRRRKVtAEADss
A0MZ66 S586 Sugiyama SHTN1 KIAA1598 RKKYIDGEKQAEPVVVLDPVsTHEPQTKDQVAEKDPTQHKE
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
O00170 T48 Sugiyama AIP XAP2 FQDGTKATFHYRtLHsDDEGtVLDDsRARGKPMELIIGKKF
O00505 S60 Sugiyama KPNA3 QIP2 KRDEHLLKKRNVPQEEsLEDsDVDADFKAQNVTLEAILQNA
O00592 T556 Sugiyama PODXL PCLP PCLP1 DsWIVPLDNLTKDDLDEEEDtHL__________________
O00629 S60 Sugiyama KPNA4 QIP1 KRDEHLLKRRNVPHEDICEDsDIDGDYRVQNtsLEAIVQNA
O14980 S1031 Sugiyama XPO1 CRM1 FKEHLRDFLVQIKEFAGEDtsDLFLEEREIALRQADEEKHK
O43423 S100 Sugiyama ANP32CP PP32R1 AEKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCE
O43615 S94 Sugiyama TIMM44 MIMT44 TIM44 NKEMKESIKKFRDEARRLEEsDVLQEARRKyKtIESETVRT
O43823 T681 Sugiyama AKAP8 AKAP95 ESAQTRVAPAPAAADAEVEQtDAEsKDAVPTE_________
O43852 S44 Sugiyama CALU KKDRVHHEPQLsDKVHNDAQsFDyDHDAFLGAEEAKtFDQL
O60220 S96 Sugiyama TIMM8A DDP DDP1 TIM8A FILNRLEQTQKSKPVFSEsLsD___________________
O60353 S648 PSP FZD6 LsGEQVDGKGQAGsVSESARsEGRIsPKsDItDtGLAQSNN
O60573 S13 Sugiyama EIF4E2 EIF4EL3 ________MNNKFDALKDDDsGDHDQNEENSTQKDGEKEKT
O60716 S252 Sugiyama CTNND1 KIAA0384 sRVtRIEERyRPsMEGyRAPsRQDVyGPQPQVRVGGssVDL
O75410 S44 Sugiyama TACC1 KIAA1103 GGAAGEDEAGGPEGDPEEEDsQAETKsLsFssDsEGNFETP
O76070 S124 GPS6|SIGNOR|EPSD SNCG BCSG1 PERSYN PRSN APQQEGEAsKEKEEVAEEAQsGGD_________________
O95218 S120 Sugiyama ZRANB2 ZIS ZNF265 tGYGGGFNERENVEyIEREEsDGEyDEFGRKKKKYRGKAVG
O95626 S104 Sugiyama ANP32D PP32R2 AEKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCE
O95757 S508 Sugiyama HSPA4L APG1 HSPH3 OSP94 GIFSVASASVIEKQNLEGDHsDAPMETEtsFKNENKDNMDK
O95816 S208 Sugiyama BAG2 IKLLEHSKGAGSKTLQQNAEsRFN_________________
P04075 S17 Sugiyama ALDOA ALDA ____MPyQyPALtPEQKKELsDIAHRIVAPGKGILAADEst
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S46 Sugiyama ALDOA ALDA PGKGILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtA
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04083 S201 Sugiyama ANXA1 ANX1 LPC1 LsLAKGDRsEDFGVNEDLADsDARALyEAGERRKGtDVNVF
P04406 S241 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 IPELNGKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKV
P04637 T55 PSP TP53 P53 LPsQAMDDLMLsPDDIEQWFtEDPGPDEAPRMPEAAPPVAP
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05187 S434 Sugiyama ALPP PLAP LYGNGPGYVLKDGARPDVtEsEsGsPEyRQQSAVPLDEETH
P05187 S436 Sugiyama ALPP PLAP GNGPGYVLKDGARPDVtEsEsGsPEyRQQSAVPLDEETHAG
P05386 S101 Sugiyama RPLP1 RRP1 APstAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD_______
P05386 S104 Sugiyama RPLP1 RRP1 tAAAPAEEKKVEAKKEEsEEsDDDMGFGLFD__________
P05387 S102 GPS6|SIGNOR|ELM|EPSD|Sugiyama RPLP2 D11S2243E RPP2 PAAGsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD_______
P05387 S105 GPS6|SIGNOR|ELM|EPSD|Sugiyama RPLP2 D11S2243E RPP2 GsAPAAAEEKKDEKKEEsEEsDDDMGFGLFD__________
P05556 S509 Sugiyama ITGB1 FNRB MDF2 MSK12 CRCNEGRVGRHCECstDEVNsEDMDAYCRKENSSEICSNNG
P05556 S689 Sugiyama ITGB1 FNRB MDF2 MSK12 NITKVEsRDKLPQPVQPDPVsHCKEKDVDDCWFYFTYSVNG
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P07237 S427 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB WDKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFP
P07237 S88 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB GKLKAEGSEIRLAKVDAtEEsDLAQQyGVRGyPtIKFFRNG
P07355 S184 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D sGDFRKLMVALAKGRRAEDGsVIDyELIDQDARDLyDAGVK
P07437 S115 Sugiyama TUBB TUBB5 OK/SW-cl.56 sGAGNNWAKGHytEGAELVDsVLDVVRKEAESCDCLQGFQL
P07550 S355 ELM|EPSD|PSP ADRB2 ADRB2R B2AR AFQELLCLRRssLKAyGNGyssNGNtGEQsGYHVEQEKENK
P07550 S356 ELM|EPSD|PSP ADRB2 ADRB2R B2AR FQELLCLRRssLKAyGNGyssNGNtGEQsGYHVEQEKENKL
P07550 S396 GPS6|ELM|EPSD|PSP ADRB2 ADRB2R B2AR LLCEDLPGtEDFVGHQGtVPsDNIDsQGRNCstNDsLL___
P07550 S401 GPS6|ELM|EPSD|PSP ADRB2 ADRB2R B2AR LPGtEDFVGHQGtVPsDNIDsQGRNCstNDsLL________
P07550 S407 GPS6|ELM|EPSD|PSP ADRB2 ADRB2R B2AR FVGHQGtVPsDNIDsQGRNCstNDsLL______________
P07550 S411 EPSD|PSP ADRB2 ADRB2R B2AR QGtVPsDNIDsQGRNCstNDsLL__________________
P07550 T384 GPS6|ELM|EPSD|PSP ADRB2 ADRB2R B2AR sGYHVEQEKENKLLCEDLPGtEDFVGHQGtVPsDNIDsQGR
P07737 S30 Sugiyama PFN1 NLMADGTCQDAAIVGYKDsPsVWAAVPGKtFVNITPAEVGV
P07814 S739 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 TKVEATKNETSAPFKERPtPsLNNNCttsEDsLVLyNRVAV
P07814 T746 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 NETSAPFKERPtPsLNNNCttsEDsLVLyNRVAVQGDVVRE
P07900 S50 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MSLIINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKL
P07900 S53 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IINtFySNKEIFLRELIsNssDALDKIRyEsLtDPsKLDsG
P07900 S641 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900 T305 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA IDQEELNKtKPIWtRNPDDItNEEyGEFyKsLtNDWEDHLA
P08069 S1278 SIGNOR|EPSD|PSP IGF1R SFLEIISSIKEEMEPGFREVsFyySEENKLPEPEELDLEPE
P08172 S232 ELM|EPSD|PSP CHRM2 ASKSRIKKDKKEPVANQDPVsPsLVQGRIVKPNNNNMPssD
P08172 S234 ELM|EPSD|PSP CHRM2 KSRIKKDKKEPVANQDPVsPsLVQGRIVKPNNNNMPssDDG
P08172 S250 ELM|EPSD|PSP CHRM2 PVsPsLVQGRIVKPNNNNMPssDDGLEHNKIQNGKAPRDPV
P08172 S251 ELM|EPSD|PSP CHRM2 VsPsLVQGRIVKPNNNNMPssDDGLEHNKIQNGKAPRDPVt
P08172 S282 ELM|EPSD|PSP CHRM2 NGKAPRDPVtENCVQGEEKEssNDstsVsAVAsNMRDDEIt
P08172 S283 ELM|EPSD|PSP CHRM2 GKAPRDPVtENCVQGEEKEssNDstsVsAVAsNMRDDEItQ
P08172 S286 ELM|EPSD|PSP CHRM2 PRDPVtENCVQGEEKEssNDstsVsAVAsNMRDDEItQDEN
P08172 S288 ELM|EPSD|PSP CHRM2 DPVtENCVQGEEKEssNDstsVsAVAsNMRDDEItQDENtV
P08172 S290 ELM|EPSD|PSP CHRM2 VtENCVQGEEKEssNDstsVsAVAsNMRDDEItQDENtVst
P08172 S294 ELM|EPSD|PSP CHRM2 CVQGEEKEssNDstsVsAVAsNMRDDEItQDENtVstsLGH
P08172 S309 ELM|EPSD|PSP CHRM2 VsAVAsNMRDDEItQDENtVstsLGHSKDENSKQTCIRIGT
P08172 S311 ELM|EPSD|PSP CHRM2 AVAsNMRDDEItQDENtVstsLGHSKDENSKQTCIRIGTKT
P08172 T271 ELM|EPSD|PSP CHRM2 sDDGLEHNKIQNGKAPRDPVtENCVQGEEKEssNDstsVsA
P08172 T287 ELM|EPSD|PSP CHRM2 RDPVtENCVQGEEKEssNDstsVsAVAsNMRDDEItQDENt
P08172 T302 ELM|EPSD|PSP CHRM2 ssNDstsVsAVAsNMRDDEItQDENtVstsLGHSKDENSKQ
P08172 T307 ELM|EPSD|PSP CHRM2 tsVsAVAsNMRDDEItQDENtVstsLGHSKDENSKQTCIRI
P08172 T310 ELM|EPSD|PSP CHRM2 sAVAsNMRDDEItQDENtVstsLGHSKDENSKQTCIRIGTK
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08670 S459 Sugiyama VIM KRTLLIKtVEtRDGQVINEtsQHHDDLE_____________
P08708 S89 Sugiyama RPS17 RPS17L ISIKLQEEERERRDNyVPEVsALDQEIIEVDPDtKEMLKLL
P08913 S311 SIGNOR ADRA2A ADRA2R ADRAR APGEPAPAGPRDTDALDLEEssssDHAERPPGPRRPERGPR
P08913 S312 SIGNOR ADRA2A ADRA2R ADRAR PGEPAPAGPRDTDALDLEEssssDHAERPPGPRRPERGPRG
P08913 S313 SIGNOR ADRA2A ADRA2R ADRAR GEPAPAGPRDTDALDLEEssssDHAERPPGPRRPERGPRGK
P08913 S314 SIGNOR ADRA2A ADRA2R ADRAR EPAPAGPRDTDALDLEEssssDHAERPPGPRRPERGPRGKG
P09497 S205 SIGNOR|EPSD|PSP CLTB EETPGTEWEKVAQLCDFNPKssKQCKDVSRLRsVLMsLKQT
P09619 S1104 GPS6|ELM|EPSD PDGFRB PDGFR PDGFR1 PELEQLPDSGCPAPRAEAEDsFL__________________
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P10696 S431 Sugiyama ALPG ALPPL ALPPL2 LYGNGPGYVLKDGARPDVtEsEsGsPEyRQQSAVPLDGETH
P10696 S433 Sugiyama ALPG ALPPL ALPPL2 GNGPGYVLKDGARPDVtEsEsGsPEyRQQSAVPLDGETHAG
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P12270 S1838 Sugiyama TPR TVSATPSSSLPKRtREEEEDstIEAsDQVsDDtVEMPLPKK
P13489 S290 Sugiyama RNH1 PRI RNH AKGCGDLCRVLRAKESLKELsLAGNELGDEGARLLCETLLE
P13639 S587 Sugiyama EEF2 EF2 CIPIKKSDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKAR
P13693 S15 Sugiyama TPT1 ______MIIYRDLIsHDEMFsDIyKIREIADGLCLEVEGKM
P13804 S197 Sugiyama ETFA ATsGGsASsEKAsStsPVEIsEWLDQKLTKSDRPELTGAKV
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14625 S172 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 VGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSELI
P14625 S306 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 TETVEEPMEEEEAAKEEKEEsDDEAAVEEEEEEKKPKTKKV
P15311 T567 GPS6|SIGNOR|ELM|EPSD|PSP EZR VIL2 RTHNDIIHNENMRQGRDKYKtLRQIRQGNTKQRIDEFEAL_
P17812 S578 Sugiyama CTPS1 CTPS GCRLsPRDtysDRsGsssPDsEItELKFPsINHD_______
P17812 T581 Sugiyama CTPS1 CTPS LsPRDtysDRsGsssPDsEItELKFPsINHD__________
P17987 S551 Sugiyama TCP1 CCT1 CCTA IKLHPESKDDKHGsyEDAVHsGALND_______________
P18545 T62 GPS6|SIGNOR|ELM|EPSD PDE6G PDEG PPKKGVQGFGDDIPGMEGLGtDITVICPWEAFNHLELHELA
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 S619 Sugiyama NCL RIVTDRETGssKGFGFVDFNsEEDAKAAKEAMEDGEIDGNK
P20042 T31 Sugiyama EIF2S2 EIF2B tMsKKKKKKKKPFMLDEEGDtQtEEtQPsETKEVEPEPtED
P20042 T33 Sugiyama EIF2S2 EIF2B sKKKKKKKKPFMLDEEGDtQtEEtQPsETKEVEPEPtEDKD
P20810 S373 Sugiyama CAST LPEPEEKPKPRsEsELIDELsEDFDRsECKEKPSKPTEKTE
P21462 S328 GPS6|SIGNOR|ELM|EPSD FPR1 FRERLIHALPASLERALtEDstQtsDtAtNstLPsAEVELQ
P21462 S332 GPS6|SIGNOR|ELM|EPSD FPR1 LIHALPASLERALtEDstQtsDtAtNstLPsAEVELQAK__
P21462 S338 GPS6|ELM|EPSD FPR1 ASLERALtEDstQtsDtAtNstLPsAEVELQAK________
P21462 T329 GPS6|SIGNOR|ELM|EPSD FPR1 RERLIHALPASLERALtEDstQtsDtAtNstLPsAEVELQA
P21462 T331 GPS6|SIGNOR|ELM|EPSD FPR1 RLIHALPASLERALtEDstQtsDtAtNstLPsAEVELQAK_
P21462 T334 GPS6|SIGNOR|ELM|EPSD FPR1 HALPASLERALtEDstQtsDtAtNstLPsAEVELQAK____
P21462 T336 GPS6|SIGNOR|ELM|EPSD FPR1 LPASLERALtEDstQtsDtAtNstLPsAEVELQAK______
P21462 T339 GPS6|SIGNOR|ELM|EPSD FPR1 SLERALtEDstQtsDtAtNstLPsAEVELQAK_________
P21731 S239 SIGNOR|PSP TBXA2R VATLCHVYHGQEAAQQRPRDsEVEMMAQLLGIMVVASVCWL
P23396 S209 Sugiyama RPS3 OK/SW-cl.26 MLPWDPTGKIGPKKPLPDHVsIVEPKDEILPttPIsEQKGG
P24752 T185 Sugiyama ACAT1 ACAT MAT RGSTPYGGVKLEDLIVKDGLtDVyNKIHMGsCAENTAKKLN
P25098 S487 Sugiyama GRK2 ADRBK1 BARK BARK1 PPPLIPPRGEVNAADAFDIGsFDEEDtKGIKLLDsDQELYR
P25098 S501 Sugiyama GRK2 ADRBK1 BARK BARK1 DAFDIGsFDEEDtKGIKLLDsDQELYRNFPLTISERWQQEV
P25098 T493 Sugiyama GRK2 ADRBK1 BARK BARK1 PRGEVNAADAFDIGsFDEEDtKGIKLLDsDQELYRNFPLTI
P25100 S300 PSP ADRA1D ADRA1A VARSTTRSLEAGVKRERGKAsEVVLRIHCRGAATGADGAHG
P25100 S323 PSP ADRA1D ADRA1A VLRIHCRGAATGADGAHGMRsAKGHtFRssLsVRLLKFSRE
P25100 S332 PSP ADRA1D ADRA1A ATGADGAHGMRsAKGHtFRssLsVRLLKFSREKKAAKTLAI
P25100 S334 PSP ADRA1D ADRA1A GADGAHGMRsAKGHtFRssLsVRLLKFSREKKAAKTLAIVV
P25100 S516 PSP ADRA1D ADRA1A EWRLLGPFRRPtTQLRAKVssLsHKIRAGGAQRAEAACAQR
P25100 S518 PSP ADRA1D ADRA1A RLLGPFRRPtTQLRAKVssLsHKIRAGGAQRAEAACAQRSE
P25101 S391 PSP EDNRA ETA ETRA FVSKKFKNCFQsCLCCCCyQsKsLMtsVPMNGtsIQWKNHD
P25101 S393 PSP EDNRA ETA ETRA SKKFKNCFQsCLCCCCyQsKsLMtsVPMNGtsIQWKNHDQN
P25101 S397 PSP EDNRA ETA ETRA KNCFQsCLCCCCyQsKsLMtsVPMNGtsIQWKNHDQNNHNt
P25101 S404 PSP EDNRA ETA ETRA LCCCCyQsKsLMtsVPMNGtsIQWKNHDQNNHNtDRssHKD
P25101 T396 PSP EDNRA ETA ETRA FKNCFQsCLCCCCyQsKsLMtsVPMNGtsIQWKNHDQNNHN
P25101 T403 PSP EDNRA ETA ETRA CLCCCCyQsKsLMtsVPMNGtsIQWKNHDQNNHNtDRssHK
P25205 S711 Sugiyama MCM3 RRKTRQPDAKDGDsyDPyDFsDtEEEMPQVHtPKTADsQEt
P25205 T198 Sugiyama MCM3 DEENNPLETEyGLSVyKDHQtITIQEMPEKAPAGQLPRSVD
P25705 S52 Sugiyama ATP5F1A ATP5A ATP5A1 ATP5AL2 ATPM AARNFHASNTHLQKtGtAEMssILEERILGADtsVDLEETG
P25786 T11 Sugiyama PSMA1 HC2 NU PROS30 PSC2 __________MFRNQyDNDVtVWsPQGRIHQIEYAMEAVKQ
P25788 S250 Sugiyama PSMA3 HC8 PSC8 KDIREEAEKyAKEsLKEEDEsDDDNM_______________
P25788 S97 Sugiyama PSMA3 HC8 PSC8 AVAGLLADARSLADIAREEAsNFRSNFGyNIPLKHLADRVA
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26038 T558 EPSD|PSP MSN KTANDMIHAENMRLGRDKYKtLRQIRQGNTKQRIDEFEsM_
P26196 S475 Sugiyama DDX6 HLR2 RCK TEIKPIPsNIDKSLyVAEyHsEPVEDEKP____________
P26639 S522 Sugiyama TARS1 TARS PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP
P27797 S189 Sugiyama CALR CRTC THLytLIVRPDNtyEVKIDNsQVEsGsLEDDWDFLPPKKIK
P27797 S214 Sugiyama CALR CRTC GsLEDDWDFLPPKKIKDPDAsKPEDWDERAKIDDPtDsKPE
P27816 S643 Sugiyama MAP4 IsPEtVTGtGKKCsLPAEEDsVLEKLGERKPCNsQPSELSS
P29401 S295 Sugiyama TKT ysQIQsKKKILAtPPQEDAPsVDIANIRMPsLPsyKVGDKI
P30041 S186 Sugiyama PRDX6 AOP2 KIAA0106 SLQLTAEKRVAtPVDWKDGDsVMVLPtIPEEEAKKLFPKGV
P30050 S138 Sugiyama RPL12 HRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDINsG
P30050 S157 Sugiyama RPL12 QsVGCNVDGRHPHDIIDDINsGAVECPAs____________
P30101 S474 Sugiyama PDIA3 ERP57 ERP60 GRP58 yFsPANKKLNPKKyEGGRELsDFIsyLQREAtNPPVIQEEK
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30411 S366 SIGNOR BDKRB2 BKR2 VyQGVCQKGGCRSEPIQMENsMGTLRTsIsVERQIHKLQDW
P30411 S373 SIGNOR BDKRB2 BKR2 KGGCRSEPIQMENsMGTLRTsIsVERQIHKLQDWAGSRQ__
P30411 S375 SIGNOR BDKRB2 BKR2 GCRSEPIQMENsMGTLRTsIsVERQIHKLQDWAGSRQ____
P31327 S835 Sugiyama CPS1 MCHPsIEGFTPRLPMNKEWPsNLDLRKELSEPSsTRIyAIA
P32245 S329 GPS6|SIGNOR|ELM|EPSD MC4R LRKtFKEIICCYPLGGLCDLssRY_________________
P32245 S330 GPS6|SIGNOR|ELM|EPSD MC4R RKtFKEIICCYPLGGLCDLssRY__________________
P32245 T312 SIGNOR|ELM MC4R MCNSIIDPLIYALRSQELRKtFKEIICCYPLGGLCDLssRY
P33993 S314 Sugiyama MCM7 CDC47 MCM2 SETyLEAHRIVKMNKSEDDEsGAGELtREELRQIAEEDFyE
P34932 T364 Sugiyama HSPA4 APG2 HSPH2 ATRIPAVKEKISKFFGKELsttLNADEAVTRGCALQCAILs
P35226 S251 Sugiyama BMI1 PCGF4 RNF51 CKRMKISHQRDGLTNAGELEsDsGsDKANSPAGGIPSTSSC
P35241 T564 EPSD|PSP RDX KTQNDVLHAENVKAGRDKYKtLRQIRQGNtKQRIDEFEAM_
P35346 T333 PSP SSTR5 QSFQKVLCLRKGSGAKDADAtEPRPDRIRQQQEAtPPAHRA
P35367 S398 GPS6|ELM|EPSD|PSP HRH1 sGsNtGLDYIKFTWKRLRsHsRQYVSGLHMNRERKAAKQLG
P35372 S357 SIGNOR OPRM1 MOR1 LyAFLDENFKRCFREFCIPtssNIEQQNsTRIRQNtRDHPs
P35372 S358 SIGNOR OPRM1 MOR1 yAFLDENFKRCFREFCIPtssNIEQQNsTRIRQNtRDHPst
P35372 S377 EPSD|PSP OPRM1 MOR1 ssNIEQQNsTRIRQNtRDHPstANtVDRTNHQLENLEAEtA
P35372 T356 SIGNOR OPRM1 MOR1 VLyAFLDENFKRCFREFCIPtssNIEQQNsTRIRQNtRDHP
P35626 S487 Sugiyama GRK3 ADRBK2 BARK2 PPPLIPPRGEVNAADAFDIGsFDEEDtKGIKLLDCDQELYK
P35626 T493 Sugiyama GRK3 ADRBK2 BARK2 PRGEVNAADAFDIGsFDEEDtKGIKLLDCDQELYKNFPLVI
P35659 S231 Sugiyama DEK SGMARKAKRTKCPEILsDEsssDEDEKKNKEEssDDEDKEs
P37802 S163 Sugiyama TAGLN2 KIAA0120 CDABP0035 LFsGDPNWFPKKSKENPRNFsDNQLQEGKNVIGLQMGtNRG
P37840 S129 GPS6|SIGNOR|ELM|EPSD|PSP SNCA NACP PARK1 QEGILEDMPVDPDNEAyEMPsEEGyQDyEPEA_________
P38646 S89 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 VMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAKRQA
P39687 S104 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 AEKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCE
P41143 S363 GPS6|SIGNOR|ELM|EPSD|PSP OPRD1 OPRD SsFSRAREATARERVtACtPsDGPGGGAAA___________
P41143 T358 GPS6|SIGNOR|ELM|EPSD OPRD1 OPRD GRPDPSsFSRAREATARERVtACtPsDGPGGGAAA______
P41143 T361 GPS6|ELM|EPSD|PSP OPRD1 OPRD DPSsFSRAREATARERVtACtPsDGPGGGAAA_________
P41146 S346 PSP OPRL1 OOR ORL1 FKACFRKFCCASALRRDVQVsDRVRsIAKDVALACKtsETV
P41146 S351 PSP OPRL1 OOR ORL1 RKFCCASALRRDVQVsDRVRsIAKDVALACKtsETVPRPA_
P41146 S363 PSP OPRL1 OOR ORL1 VQVsDRVRsIAKDVALACKtsETVPRPA_____________
P41146 T362 PSP OPRL1 OOR ORL1 DVQVsDRVRsIAKDVALACKtsETVPRPA____________
P41227 S213 Sugiyama NAA10 ARD1 ARD1A TE2 ACREEKGLAAEDsGGDsKDLsEVsEtTEstDVKDssEAsDs
P41227 S216 Sugiyama NAA10 ARD1 ARD1A TE2 EEKGLAAEDsGGDsKDLsEVsEtTEstDVKDssEAsDsAs_
P43121 T298 Sugiyama MCAM MUC18 PPPHFSISKQNPstREAEEEttNDNGVLVLEPARKEHSGRY
P43487 S60 Sugiyama RANBP1 TLEEDEEELFKMRAKLFRFAsENDLPEWKERGTGDVKLLKH
P47756 T202 Sugiyama CAPZB SGsGtMNLGGsLtRQMEKDEtVsDCsPHIANIGRLVEDMEN
P49321 S176 Sugiyama NASP EAKKTEDKSLAKPEtDKEQDsEMEKGGREDMDIsKsAEEPQ
P49588 Y192 Sugiyama AARS1 AARS KDNFWEMGDtGPCGPCsEIHyDRIGGRDAAHLVNQDDPNVL
P50502 S79 Sugiyama ST13 AAG2 FAM10A1 HIP SNC6 KPDSKKVEEDLKADEPssEEsDLEIDKEGVIEPDTDAPQEM
P51681 S336 GPS6|ELM|EPSD CCR5 CMKBR5 IAKRFCKCCSIFQQEAPERAssVyTRsTGEQEIsVGL____
P51681 S337 GPS6|ELM|EPSD CCR5 CMKBR5 AKRFCKCCSIFQQEAPERAssVyTRsTGEQEIsVGL_____
P51681 S342 GPS6|ELM|EPSD CCR5 CMKBR5 KCCSIFQQEAPERAssVyTRsTGEQEIsVGL__________
P51681 S349 GPS6|ELM|EPSD CCR5 CMKBR5 QEAPERAssVyTRsTGEQEIsVGL_________________
P53985 S467 Sugiyama SLC16A1 MCT1 LLAKEQKANEQKKEsKEEEtsIDVAGKPNEVTKAAEsPDQK
P53985 T466 Sugiyama SLC16A1 MCT1 RLLAKEQKANEQKKEsKEEEtsIDVAGKPNEVTKAAEsPDQ
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P53999 S9 Sugiyama SUB1 PC4 RPO2TC1 ____________MPKSKELVsssssGsDsDsEVDKKLKRKK
P54578 S492 Sugiyama USP14 TGT WHIAYVLLYGPRRVEIMEEEsEQ__________________
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P55060 S366 Sugiyama CSE1L CAS XPO2 KVIVPNMEFRAADEEAFEDNsEEyIRRDLEGsDIDTRRRAA
P60709 S199 Sugiyama ACTB DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 S52 Sugiyama ACTB PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P61247 S236 Sugiyama RPS3A FTE1 MFTL KMLKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGy
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P62081 S174 Sugiyama RPS7 IKVHLDKAQQNNVEHKVEtFsGVyKKLTGKDVNFEFPEFQL
P62263 S137 Sugiyama RPS14 PRO2640 RALARSGMKIGRIEDVtPIPsDstRRKGGRRGRRL______
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62736 S54 Sugiyama ACTA2 ACTSA ACTVS GIG46 PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63220 S68 Sugiyama RPS21 GQFKtyAICGAIRRMGEsDDsILRLAKADGIVSKNF_____
P63261 S199 Sugiyama ACTG1 ACTG DLAGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyV
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 S52 Sugiyama ACTG1 ACTG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKYPIE
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63267 S53 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 S54 Sugiyama ACTC1 ACTC PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 S54 Sugiyama ACTA1 ACTA PsIVGRPRHQGVMVGMGQKDsyVGDEAQsKRGILTLKyPIE
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T80 Sugiyama TUBA1B KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P98082 S241 Sugiyama DAB2 DOC2 tPPDLNsPtEsKDILLVDLNsEIDtNQNSLRENPFLTNGIT
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q01130 S212 Sugiyama SRSF2 SFRS2 PPPVsKRESKSRSRsKsPPKsPEEEGAVss___________
Q04637 S1430 Sugiyama EIF4G1 EIF4F EIF4G EIF4GI GQDIGAFVAEQKVEyTLGEEsEAPGQRALPsEELNRQLEKL
Q04726 S197 Sugiyama TLE3 KIAA1547 HLTVKDEKNHHELDHREREssANNsVsPsEsLRAsEKHRGs
Q04864 S272 Sugiyama REL AITEPVTVKMQLRRPSDQEVsEsMDFRYLPDEKDTYGNKAK
Q07021 S201 Sugiyama C1QBP GC1QBP HABP1 SF2P32 ALVLDCHyPEDEVGQEDEAEsDIFsIREVsFQstGESEWKD
Q07021 S210 Sugiyama C1QBP GC1QBP HABP1 SF2P32 EDEVGQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDS
Q08211 S125 Sugiyama DHX9 DDX9 LKP NDH2 LPttMGGPLPPHLALKAENNsEVGAsGyGVPGPTWDRGANL
Q12904 T280 Sugiyama AIMP1 EMAP2 SCYE1 PDKELNPKKKIWEQIQPDLHtNDECVAtyKGVPFEVKGKGV
Q13011 S43 Sugiyama ECH1 NYPGLSISLRLtGssAQEEAsGVALGEAPDHSYESLRVTSA
Q13057 S507 Sugiyama COASY PSEC0106 WTAVIPETEAVRRIVERDGLsEAAAQSRLQSQMSGQQLVEQ
Q13263 S479 Sugiyama TRIM28 KAP1 RNF96 TIF1B ssAEPHVsGVKRsRsGEGEVsGLMRKVPRVsLERLDLDLtA
Q13283 S232 Sugiyama G3BP1 G3BP EEKPEPVLEETAPEDAQKsssPAPADIAQtVQEDLRtFsWA
Q13509 S115 Sugiyama TUBB3 TUBB4 SGAGNNWAKGHytEGAELVDsVLDVVRKECENCDCLQGFQL
Q13509 S420 GPS6|ELM|EPSD TUBB3 TUBB4 GEGMDEMEFtEAESNMNDLVsEYQQYQDATAEEEGEMYEDD
Q13509 S444 GPS6|ELM|EPSD TUBB3 TUBB4 QYQDATAEEEGEMYEDDEEEsEAQGPK______________
Q13509 T409 GPS6|ELM|EPSD TUBB3 TUBB4 FRRKAFLHWYTGEGMDEMEFtEAESNMNDLVsEYQQYQDAT
Q13541 S112 Sugiyama EIF4EBP1 EAsQsHLRNsPEDKRAGGEEsQFEMDI______________
Q13547 S421 Sugiyama HDAC1 RPD3L1 PDKRIsICssDKRIACEEEFsDsEEEGEGGRKNsSNFKKAK
Q13885 S115 Sugiyama TUBB2A TUBB2 sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q14152 S1308 Sugiyama EIF3A EIF3S10 KIAA0139 DLRDDRDRRGPPLRSEREEVsSWRRADDRKDDRVEERDPPR
Q14152 S907 Sugiyama EIF3A EIF3S10 KIAA0139 DSRWGDRDsEGtWRKGPEADsEWRRGPPEKEWRRGEGRDED
Q14152 T1378 Sugiyama EIF3A EIF3S10 KIAA0139 AEKDREsLRRTKNEtDEDGWttVRR________________
Q14155 S518 Sugiyama ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314 ERYLLLFPNVLLMLSASPRMsGFIyQGKLPtTGMTITKLED
Q14203 S417 Sugiyama DCTN1 KKNQELEVVRQQRERLQEELsQAEstIDELKEQVDAALGAE
Q14204 T1307 Sugiyama DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 FGRLKDDREKCAKAKEALELtDtGLLsGSEERVQVALEELQ
Q14257 T301 Sugiyama RCN2 ERC55 KKLsEEEILENPDLFLtsEAtDyGRQLHDDyFyHDEL____
Q14568 S50 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 MSLIINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKL
Q14568 S53 Sugiyama HSP90AA2P HSP90AA2 HSPC2 HSPCAL3 IINTFYSNKEIFLRELIsNssDALDKIWYESLTDPSKLDSG
Q14940 S702 SIGNOR|EPSD|PSP SLC9A5 NHE5 NGKHRGLGFQDTAAVILTVEsEEEEEEsDssEtEKEDDEGI
Q14940 S709 SIGNOR|EPSD|PSP SLC9A5 NHE5 GFQDTAAVILTVEsEEEEEEsDssEtEKEDDEGIIFVARAT
Q14940 S711 SIGNOR|EPSD|PSP SLC9A5 NHE5 QDTAAVILTVEsEEEEEEsDssEtEKEDDEGIIFVARATSE
Q14940 S712 SIGNOR|EPSD|PSP SLC9A5 NHE5 DTAAVILTVEsEEEEEEsDssEtEKEDDEGIIFVARATSEV
Q14940 T714 SIGNOR|EPSD|PSP SLC9A5 NHE5 AAVILTVEsEEEEEEsDssEtEKEDDEGIIFVARATSEVLQ
Q15021 S1330 Sugiyama NCAPD2 CAPD2 CNAP1 KIAA0159 sQRAPsAKKPSTGSRyQPLAstAsDNDFVtPEPRRTTRRHP
Q15052 S488 Sugiyama ARHGEF6 COOL2 KIAA0006 PIXA ERYLMLFSNVLIMLSASPRMsGFIYQGKIPIAGTVVTRLDE
Q15084 S428 Sugiyama PDIA6 ERP5 P5 TXNDC7 EREPWDGRDGELPVEDDIDLsDVELDDLGKDEL________
Q15084 T166 Sugiyama PDIA6 ERP5 P5 TXNDC7 YSSGKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFY
Q15758 S539 Sugiyama SLC1A5 ASCT2 M7V1 RDR RDRC PLLKHyRGPAGDAtVAsEKEsVM__________________
Q15796 T197 EPSD|PSP SMAD2 MADH2 MADR2 PVLVPRHTEILTELPPLDDYtHSIPENTNFPAGIEPQSNYI
Q16143 S118 GPS6|EPSD SNCB VAQEAAEEPLIEPLMEPEGEsYEDPPQEEyQEYEPEA____
Q16539 T123 SIGNOR|EPSD|PSP MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A YLVTHLMGADLNNIVKCQKLtDDHVQFLIYQILRGLKYIHs
Q562R1 T107 Sugiyama ACTBL2 WYHTFYNELRVAPDEHPILLtEAPLNPKINREKMTQIMFEA
Q56P03 S111 Sugiyama EAPP C14orf11 BM-036 NGKVATAPTRyYDDIyFDsDsEDEDRAVQVtKKKKKKQHKI
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q5T4S7 S2910 Sugiyama UBR4 KIAA0462 KIAA1307 RBAF600 GGsVGsEsGGsAVDsVAGEHsVsGRSSAYGDATAEGHPAGP
Q6P996 S779 Sugiyama PDXDC1 KIAA0251 QHtDQtEAFQKGVPHPEDDHsQVEGPEsLR___________
Q6PKG0 S631 Sugiyama LARP1 KIAA0731 LARP EEMEQMDGRKNtFtAWsDEEsDyEIDDRDVNKILIVtQtPH
Q6PKG0 T769 Sugiyama LARP1 KIAA0731 LARP ALANKLFGAPEPstIARsLPttVPEsPNyRNtRtPRtPRtP
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6UXH1 S295 Sugiyama CRELD2 UNQ185/PRO211 KECISGYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSY
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T80 Sugiyama TUBA1A TUBA3 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q7Z460 S246 Sugiyama CLASP1 KIAA0622 MAST1 VQKSGNMIQSANDKNFDDEDsVDGNRPssAsStSSKAPPSS
Q86XZ4 S166 Sugiyama SPATS2 SCR59 SPATA10 Nbla00526 sLSEGLETLSIDARELEDPEsAMLDTLDRTGSMLQNGVSDF
Q8IWE2 T401 Sugiyama FAM114A1 NOXP20 TPDKLNKAMKRAHDWVEEDQtVVSVDVAKVSEEETKKEEKE
Q8IWX8 S822 Sugiyama CHERP DAN26 SCAF6 SKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRLGEE
Q8IWX8 T819 Sugiyama CHERP DAN26 SCAF6 RSRSKSYSPGRRRRsRsRsPtPPssAGLGsNsAPPIPDSRL
Q8N4Q1 T127 Sugiyama CHCHD4 MIA40 QEDEDEEEEREKKPAEQAEEtAPIEATAtKEEEGss_____
Q8N4Q1 T135 Sugiyama CHCHD4 MIA40 EREKKPAEQAEEtAPIEATAtKEEEGss_____________
Q8NBS9 S292 Sugiyama TXNDC5 TLP46 UNQ364/PRO700 KKVDQYKGKRDLEsLREyVEsQLQRTETGATETVTPSEAPV
Q8NEM2 S42 Sugiyama SHCBP1 GWAVEQELASLEKGLFQDEDsCsDCsYRDKPGssLQSFMPE
Q8NEN9 S496 Sugiyama PDZD8 PDZK8 SGYEEEAAGLTVDTESRELDsEFEDLAsDVRAQNEFKDEAQ
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8TDU6 S310 PSP GPBAR1 TGR5 PWRAAAQRCLQGLWGRASRDsPGPSIAYHPSsQssVDLDLN
Q8TDU6 S321 PSP GPBAR1 TGR5 GLWGRASRDsPGPSIAYHPSsQssVDLDLN___________
Q8TDU6 S323 PSP GPBAR1 TGR5 WGRASRDsPGPSIAYHPSsQssVDLDLN_____________
Q8TDU6 S324 PSP GPBAR1 TGR5 GRASRDsPGPSIAYHPSsQssVDLDLN______________
Q8WVJ2 S142 Sugiyama NUDCD2 LTLERFQKENPGFDFsGAEIsGNytKGGPDFsNLEK_____
Q92769 S422 Sugiyama HDAC2 PDKRIsIRAsDKRIACDEEFsDsEDEGEGGRRNVADHKKGA
Q92847 S252 PSP GHSR YSLIGRKLWRRRRGDAVVGAsLRDQNHKQtVKMLAVVVFAF
Q92890 T210 Sugiyama UFD1 UFD1L DFDAPLGYKEPERQVQHEEstEGEADHsGyAGELGFRAFsG
Q92973 S339 Sugiyama TNPO1 KPNB2 MIP1 TRN SDIDIILLKGDVEEDEtIPDsEQDIRPRFHRSRTVAQQHDE
Q96A54 S205 SIGNOR|PSP ADIPOR1 PAQR1 TESBP1A CGI-45 SFSWLFHTVYCHSEKVSRTFsKLDYSGIALLIMGSFVPWLY
Q96A54 S7 EPSD|PSP ADIPOR1 PAQR1 TESBP1A CGI-45 ______________MSSHKGsVVAQGNGAPASNREADtVEL
Q96A54 T24 EPSD|PSP ADIPOR1 PAQR1 TESBP1A CGI-45 HKGsVVAQGNGAPASNREADtVELAELGPLLEEKGKRVIAN
Q96A54 T53 EPSD|PSP ADIPOR1 PAQR1 TESBP1A CGI-45 LLEEKGKRVIANPPKAEEEQtCPVPQEEEEEVRVLtLPLQA
Q96C19 S237 Sugiyama EFHD2 SWS1 ERKKQAEEMKQRKAAFKELQsTFK_________________
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96K76 S903 Sugiyama USP47 LSLQQQQDGDNGDssKstEtsDFENIEsPLNERDsSAsVDN
Q96PZ0 S23 Sugiyama PUS7 KIAA1897 MTEMTGVSLKRGALVVEDNDsGVPVEETKKQKLsECsLTKG
Q96QK1 S760 Sugiyama VPS35 MEM3 TCCCTA00141 IQVLNQLIQKIREDLPNLEssEEtEQINKHFHNtLEHLRLR
Q96QK1 T763 Sugiyama VPS35 MEM3 TCCCTA00141 LNQLIQKIREDLPNLEssEEtEQINKHFHNtLEHLRLRREs
Q96S66 S59 Sugiyama CLCC1 KIAA0761 MCLC MRKSQAKYGISGEKDVSPDLsCADEIsECyHKLDSLTYKID
Q96S66 S65 Sugiyama CLCC1 KIAA0761 MCLC KYGISGEKDVSPDLsCADEIsECyHKLDSLTYKIDECEKKK
Q96S66 Y68 Sugiyama CLCC1 KIAA0761 MCLC ISGEKDVSPDLsCADEIsECyHKLDSLTYKIDECEKKKRED
Q99613 S154 Sugiyama EIF3C EIF3S8 NAKALSTLRQKIRKyNRDFEsHItSyKQNPEQsADEDAEKN
Q99733 S125 Sugiyama NAP1L4 NAP2 KRREFItGDVEPtDAEsEWHsENEEEEKLAGDMKSKVVVTE
Q99733 T117 Sugiyama NAP1L4 NAP2 ALyQPLFDKRREFItGDVEPtDAEsEWHsENEEEEKLAGDM
Q99816 S299 Sugiyama TSG101 QEVAEVDKNIELLKKKDEELssALEKMENQsENNDIDEVII
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T80 Sugiyama TUBA1C TUBA6 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BVA1 S115 Sugiyama TUBB2B sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q9BVS4 S380 Sugiyama RIOK2 RIO2 EEsEGCYCRssGDPEQIKEDsLsEEsADARsFEMTEFNQAL
Q9BW91 S343 Sugiyama NUDT9 NUDT10 PSEC0099 UNQ3012/PRO9771 SHSQFIKLVAEKRDAHWSEDsEADCHAL_____________
Q9BX95 T114 Sugiyama SGPP1 SPP1 AAELGPAsPRRAGALRRNsLtGEEGQLARVSNWPLYCLFCF
Q9BYW2 S1415 Sugiyama SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069 KNDIKDRGPLKKRRQEIEsDsEsDGELQDRKKVRVEVEQGE
Q9BYW2 S1417 Sugiyama SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069 DIKDRGPLKKRRQEIEsDsEsDGELQDRKKVRVEVEQGETS
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9H2K8 S331 Sugiyama TAOK3 DPK JIK KDS MAP3K18 ILFQETRNGPLNEsQEDEEDsEHGTsLNREMDSLGSNHSIP
Q9H3P7 S393 Sugiyama ACBD3 GCP60 GOCAP1 GOLPH1 SMWTRPQIKDFKEKIQQDADsVItVGRGEVVTVRVPTHEEG
Q9H4A5 S27 Sugiyama GOLPH3L GPP34R RARRTEISKNSEKKMEsEEDsNWEKSPDNEDSGDSKDIRLT
Q9NPQ8 T441 Sugiyama RIC8A AARGLMAGGRPEGQysEDEDtDtDEyKEAKAsINPVTGRVE
Q9NR28 S230 Sugiyama DIABLO SMAC EAQIEELRQKTQEEGEERAEsEQEAyLRED___________
Q9NR30 S121 Sugiyama DDX21 PIEKKVVSSKTKKVTKNEEPsEEEIDAPKPKKMKKEKEMNG
Q9NRX4 T119 Sugiyama PHPT1 PHP14 CGI-202 HSPC141 PAQHAISTEKIKAKyPDyEVtWANDGy______________
Q9NWB6 S77 Sugiyama ARGLU1 RsRstNTAVSRRERDRERAssPPDRIDIFGRTVSKRSSLDE
Q9NYU2 T371 Sugiyama UGGT1 GT UGCGL1 UGGT UGT1 UGTR QNFPTKARAITKTAVsSELRtEVEENQKYFKGTLGLQPGDS
Q9P258 S15 Sugiyama RCC2 KIAA1470 TD60 ______MPRKKAAAAAWEEPssGNGtARAGPRKRGGPAGRK
Q9P2I0 S419 Sugiyama CPSF2 CPSF100 KIAA1367 EKLKKEAAKKLEQSKEADIDssDEsDIEEDIDQPSAHKTKH
Q9UBV2 S66 Sugiyama SEL1L TSA305 UNQ128/PRO1063 KDHTTAGRVVAGQIFLDsEEsELEssIQEEEDSLKSQEGES
Q9UBV2 S71 Sugiyama SEL1L TSA305 UNQ128/PRO1063 AGRVVAGQIFLDsEEsELEssIQEEEDSLKSQEGESVTEDI
Q9UI30 T123 Sugiyama TRMT112 AD-001 HSPC152 HSPC170 SGRMFPISRGIPNMLLsEEEtEs__________________
Q9UQ80 T386 Sugiyama PA2G4 EBP1 tQKKKKKKAsKtAENAtsGEtLEENEAGD____________
Q9Y2W7 S95 EPSD|PSP KCNIP3 CSEN DREAM KCHIP3 QPEGLDQLQAQTKFTKKELQsLYRGFKNECPTGLVDEDTFK
Q9Y2X7 S385 Sugiyama GIT1 DNLELsLRSQSDLDDQHDyDsVAsDEDtDQEPLRSTGATRS
Q9Y3F4 S312 Sugiyama STRAP MAWD UNRIP WQTVVGKtyGLWKCVLPEEDsGELAKPKIGFPETTEEELEE
Q9Y3U8 S91 Sugiyama RPL36 KFIKKRVGTHIRAKRKREELsNVLAAMRKAAAKKD______
Q9Y5S9 S56 Sugiyama RBM8A RBM8 HSPC114 MDS014 KGRGFGsEEGsRARMREDyDsVEQDGDEPGPQRSVEGWILF
Q9Y5X5 S519 PSP NPFFR2 GPR74 NPFF2 NPGPR KsAEKPQQELVMEELKEttNssEI_________________
Q9Y5X5 S520 PSP NPFFR2 GPR74 NPFF2 NPGPR sAEKPQQELVMEELKEttNssEI__________________
Q9Y5X5 T516 PSP NPFFR2 GPR74 NPFF2 NPGPR LYRKsAEKPQQELVMEELKEttNssEI______________
Q9Y5X5 T517 PSP NPFFR2 GPR74 NPFF2 NPGPR YRKsAEKPQQELVMEELKEttNssEI_______________
Q9Y696 T231 Sugiyama CLIC4 PKEMTGIWRYLtNAysRDEFtNtCPsDKEVEIAysDVAKRL
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Apoptotic cleavage of cellular proteins R-HSA-111465 1.480768e-08 7.830 0 0
Apoptotic execution phase R-HSA-75153 2.343917e-07 6.630 0 0
Cell Cycle R-HSA-1640170 3.148983e-07 6.502 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.833186e-06 5.316 0 0
Cell Cycle, Mitotic R-HSA-69278 9.405747e-06 5.027 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 9.709356e-06 5.013 0 0
Signal Transduction R-HSA-162582 9.424797e-06 5.026 1 0
Membrane Trafficking R-HSA-199991 1.508959e-05 4.821 1 0
Mitotic Prometaphase R-HSA-68877 2.593309e-05 4.586 0 0
Signaling by EGFR R-HSA-177929 3.650755e-05 4.438 0 0
M Phase R-HSA-68886 3.966827e-05 4.402 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.154800e-04 3.937 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.195617e-04 3.922 0 0
Nuclear Envelope Breakdown R-HSA-2980766 1.320453e-04 3.879 0 0
L1CAM interactions R-HSA-373760 1.362031e-04 3.866 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.291659e-04 3.889 0 0
Signaling by Hippo R-HSA-2028269 1.858345e-04 3.731 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.062529e-04 3.686 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 2.136941e-04 3.670 0 0
Signaling by VEGF R-HSA-194138 2.157152e-04 3.666 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 2.368601e-04 3.626 0 0
Nervous system development R-HSA-9675108 2.444963e-04 3.612 0 0
Cellular response to heat stress R-HSA-3371556 2.546713e-04 3.594 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 2.546713e-04 3.594 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 2.701072e-04 3.568 0 0
Oncogenic MAPK signaling R-HSA-6802957 3.063858e-04 3.514 0 0
Signaling by MET R-HSA-6806834 3.546843e-04 3.450 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.695370e-04 3.432 0 0
Axon guidance R-HSA-422475 4.019601e-04 3.396 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 3.919468e-04 3.407 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 4.259403e-04 3.371 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 4.396895e-04 3.357 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.662058e-04 3.331 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 4.760718e-04 3.322 0 0
Cell-Cell communication R-HSA-1500931 4.898861e-04 3.310 0 0
Negative regulation of MET activity R-HSA-6807004 5.007573e-04 3.300 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 5.290716e-04 3.276 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 5.543865e-04 3.256 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 5.635507e-04 3.249 0 0
Separation of Sister Chromatids R-HSA-2467813 5.679088e-04 3.246 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 6.339162e-04 3.198 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 6.408605e-04 3.193 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 7.173539e-04 3.144 0 0
Chromatin organization R-HSA-4839726 7.324862e-04 3.135 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.438040e-04 3.129 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 8.839936e-04 3.054 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 8.839936e-04 3.054 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 8.932719e-04 3.049 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 9.047930e-04 3.043 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 9.047930e-04 3.043 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 7.999413e-04 3.097 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.606548e-04 3.065 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 7.999413e-04 3.097 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 7.999413e-04 3.097 0 0
Mitotic Anaphase R-HSA-68882 9.058685e-04 3.043 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 9.812413e-04 3.008 0 0
ISG15 antiviral mechanism R-HSA-1169408 9.930450e-04 3.003 0 0
MITF-M-dependent gene expression R-HSA-9856651 1.049655e-03 2.979 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.069816e-03 2.971 1 1
Signaling by RAF1 mutants R-HSA-9656223 1.179530e-03 2.928 0 0
Chromatin modifying enzymes R-HSA-3247509 1.206451e-03 2.918 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.289279e-03 2.890 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 1.403042e-03 2.853 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 1.403042e-03 2.853 0 0
MTOR signalling R-HSA-165159 1.419810e-03 2.848 0 0
Mitotic Spindle Checkpoint R-HSA-69618 1.425852e-03 2.846 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 1.430675e-03 2.844 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 1.905347e-03 2.720 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.900554e-03 2.721 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 1.878851e-03 2.726 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 1.726467e-03 2.763 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.905347e-03 2.720 0 0
Formation of definitive endoderm R-HSA-9823730 1.915266e-03 2.718 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.965926e-03 2.706 1 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 1.974572e-03 2.705 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 1.974572e-03 2.705 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.023808e-03 2.694 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.203432e-03 2.657 0 0
Nuclear import of Rev protein R-HSA-180746 2.108764e-03 2.676 0 0
MET interacts with TNS proteins R-HSA-8875513 2.317176e-03 2.635 0 0
Cell Cycle Checkpoints R-HSA-69620 2.352932e-03 2.628 0 0
Regulation of TP53 Activity R-HSA-5633007 2.575296e-03 2.589 0 0
Signaling by RAS mutants R-HSA-6802949 2.826462e-03 2.549 0 0
Signaling downstream of RAS mutants R-HSA-9649948 2.826462e-03 2.549 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 2.826462e-03 2.549 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 2.826462e-03 2.549 0 0
Apoptosis R-HSA-109581 3.043143e-03 2.517 0 0
Metabolism of non-coding RNA R-HSA-194441 3.282626e-03 2.484 0 0
snRNP Assembly R-HSA-191859 3.282626e-03 2.484 0 0
Recycling pathway of L1 R-HSA-437239 3.316380e-03 2.479 0 0
AURKA Activation by TPX2 R-HSA-8854518 3.658719e-03 2.437 0 0
Amplification of signal from the kinetochores R-HSA-141424 4.023033e-03 2.395 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 4.023033e-03 2.395 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.937007e-03 2.405 0 0
Mitotic Prophase R-HSA-68875 3.910335e-03 2.408 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 4.098436e-03 2.387 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 4.153840e-03 2.382 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 4.153840e-03 2.382 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 4.609105e-03 2.336 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 4.642105e-03 2.333 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 4.642105e-03 2.333 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 4.989402e-03 2.302 0 0
Striated Muscle Contraction R-HSA-390522 4.989402e-03 2.302 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.041112e-03 2.297 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 5.056717e-03 2.296 0 0
Deubiquitination R-HSA-5688426 5.079458e-03 2.294 0 0
MAPK family signaling cascades R-HSA-5683057 5.203653e-03 2.284 0 0
DCC mediated attractive signaling R-HSA-418885 5.206772e-03 2.283 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.206772e-03 2.283 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.114160e-03 2.214 0 0
Autophagy R-HSA-9612973 5.900989e-03 2.229 0 0
Regulation of CDH1 Function R-HSA-9764561 5.842404e-03 2.233 0 0
Vesicle-mediated transport R-HSA-5653656 6.198046e-03 2.208 1 0
Mitotic Telophase/Cytokinesis R-HSA-68884 6.421035e-03 2.192 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 6.699348e-03 2.174 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 7.081377e-03 2.150 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.144676e-03 2.146 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 7.214339e-03 2.142 0 0
Cell junction organization R-HSA-446728 8.056381e-03 2.094 0 0
EGFR downregulation R-HSA-182971 8.090708e-03 2.092 0 0
Repression of WNT target genes R-HSA-4641265 8.649399e-03 2.063 0 0
EPH-Ephrin signaling R-HSA-2682334 9.364034e-03 2.029 0 0
Signaling by ERBB2 R-HSA-1227986 8.593575e-03 2.066 0 0
Viral Messenger RNA Synthesis R-HSA-168325 9.710251e-03 2.013 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 9.737762e-03 2.012 0 0
RUNX3 regulates RUNX1-mediated transcription R-HSA-8951911 9.784658e-03 2.009 0 0
Post NMDA receptor activation events R-HSA-438064 1.015464e-02 1.993 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.106031e-02 1.956 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.120997e-02 1.950 0 0
Integrin signaling R-HSA-354192 1.134986e-02 1.945 0 0
Nucleotide Excision Repair R-HSA-5696398 1.044324e-02 1.981 0 0
HIV Life Cycle R-HSA-162587 1.092776e-02 1.961 0 0
ESR-mediated signaling R-HSA-8939211 1.064862e-02 1.973 0 0
tRNA processing in the nucleus R-HSA-6784531 1.093843e-02 1.961 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 1.093843e-02 1.961 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.179513e-02 1.928 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 1.179513e-02 1.928 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.228532e-02 1.911 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.228532e-02 1.911 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.244677e-02 1.905 0 0
Signaling by ALK in cancer R-HSA-9700206 1.244677e-02 1.905 0 0
mTORC1-mediated signalling R-HSA-166208 1.246578e-02 1.904 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.343255e-02 1.872 0 0
Ephrin signaling R-HSA-3928664 1.379043e-02 1.860 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 1.446249e-02 1.840 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 1.467637e-02 1.833 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 1.505883e-02 1.822 0 0
ER to Golgi Anterograde Transport R-HSA-199977 1.526273e-02 1.816 0 0
Regulation of CDH11 function R-HSA-9762292 1.446249e-02 1.840 0 0
Macroautophagy R-HSA-1632852 1.566537e-02 1.805 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 1.581723e-02 1.801 0 0
Developmental Biology R-HSA-1266738 1.642934e-02 1.784 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 1.737999e-02 1.760 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.765967e-02 1.753 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.765967e-02 1.753 0 0
Regulation of PTEN gene transcription R-HSA-8943724 1.846050e-02 1.734 0 0
Kinesins R-HSA-983189 1.846050e-02 1.734 0 0
mRNA Splicing - Major Pathway R-HSA-72163 1.847139e-02 1.734 0 0
Estrogen-dependent gene expression R-HSA-9018519 1.853738e-02 1.732 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.879883e-02 1.726 0 0
MAP2K and MAPK activation R-HSA-5674135 1.984571e-02 1.702 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.984571e-02 1.702 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.027960e-02 1.693 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 2.313625e-02 1.636 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 2.256051e-02 1.647 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 2.122756e-02 1.673 0 0
mRNA Splicing R-HSA-72172 2.239643e-02 1.650 0 0
TGFBR3 expression R-HSA-9839394 2.138130e-02 1.670 0 0
Nephrin family interactions R-HSA-373753 2.063835e-02 1.685 0 0
HDMs demethylate histones R-HSA-3214842 2.138130e-02 1.670 0 0
Gene expression (Transcription) R-HSA-74160 2.132042e-02 1.671 0 0
Programmed Cell Death R-HSA-5357801 2.368085e-02 1.626 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.437537e-02 1.613 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 2.553368e-02 1.593 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 2.766717e-02 1.558 0 0
RUNX2 regulates genes involved in differentiation of myeloid cells R-HSA-8941333 2.821230e-02 1.550 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 2.821230e-02 1.550 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.154296e-02 1.501 0 0
Disorders of Nervous System Development R-HSA-9697154 3.154296e-02 1.501 0 0
Pervasive developmental disorders R-HSA-9005895 3.154296e-02 1.501 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 3.154296e-02 1.501 0 0
Signaling by PDGFR in disease R-HSA-9671555 2.955381e-02 1.529 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 2.955381e-02 1.529 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 3.232678e-02 1.490 0 0
Nuclear RNA decay R-HSA-9930044 2.845328e-02 1.546 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.967489e-02 1.528 0 0
Signaling by LTK R-HSA-9842663 3.154296e-02 1.501 0 0
RAF/MAP kinase cascade R-HSA-5673001 3.087424e-02 1.510 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 2.955381e-02 1.529 0 0
Metabolism of RNA R-HSA-8953854 3.052628e-02 1.515 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.076916e-02 1.512 0 0
Rab regulation of trafficking R-HSA-9007101 3.167789e-02 1.499 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.845328e-02 1.546 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.240263e-02 1.489 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.240263e-02 1.489 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 2.938323e-02 1.532 0 0
Signaling by ALK R-HSA-201556 3.076916e-02 1.512 0 0
Inositol phosphate metabolism R-HSA-1483249 3.262101e-02 1.487 0 0
Formation of annular gap junctions R-HSA-196025 3.285217e-02 1.483 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 3.313591e-02 1.480 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.389922e-02 1.470 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.437200e-02 1.464 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.437200e-02 1.464 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.621518e-02 1.441 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.625582e-02 1.441 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 4.143813e-02 1.383 0 0
IRS activation R-HSA-74713 4.143813e-02 1.383 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.143813e-02 1.383 0 0
ARMS-mediated activation R-HSA-170984 4.284723e-02 1.368 0 0
Regulation of commissural axon pathfinding by SLIT and ROBO R-HSA-428542 4.284723e-02 1.368 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 4.284723e-02 1.368 0 0
Gap junction degradation R-HSA-190873 4.284723e-02 1.368 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.284723e-02 1.368 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 4.111288e-02 1.386 0 0
Centrosome maturation R-HSA-380287 4.037011e-02 1.394 0 0
PTEN Regulation R-HSA-6807070 3.716323e-02 1.430 0 0
Signalling to ERKs R-HSA-187687 4.209084e-02 1.376 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.284723e-02 1.368 0 0
Unwinding of DNA R-HSA-176974 4.284723e-02 1.368 0 0
Selective autophagy R-HSA-9663891 3.893957e-02 1.410 0 0
Breakdown of the nuclear lamina R-HSA-352238 4.252754e-02 1.371 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 4.181078e-02 1.379 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.075656e-02 1.390 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 3.923776e-02 1.406 0 0
S Phase R-HSA-69242 4.276930e-02 1.369 0 0
NrCAM interactions R-HSA-447038 4.143813e-02 1.383 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 3.912277e-02 1.408 0 0
Death Receptor Signaling R-HSA-73887 3.874310e-02 1.412 0 0
Regulation of gene expression in beta cells R-HSA-210745 3.923776e-02 1.406 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.075656e-02 1.390 0 0
PI Metabolism R-HSA-1483255 4.289319e-02 1.368 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 4.289319e-02 1.368 0 0
Interleukin-37 signaling R-HSA-9008059 4.490459e-02 1.348 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 4.726894e-02 1.325 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 4.726894e-02 1.325 0 0
Regulation of TP53 Degradation R-HSA-6804757 4.747219e-02 1.324 0 0
Mitotic G2-G2/M phases R-HSA-453274 4.771538e-02 1.321 0 0
Signal regulatory protein family interactions R-HSA-391160 4.791811e-02 1.320 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.797011e-02 1.319 0 0
Semaphorin interactions R-HSA-373755 4.925038e-02 1.308 0 0
Gap junction trafficking and regulation R-HSA-157858 4.955771e-02 1.305 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.108346e-02 1.292 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 5.108346e-02 1.292 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.329084e-02 1.273 0 0
Signal attenuation R-HSA-74749 5.436767e-02 1.265 0 0
Folding of actin by CCT/TriC R-HSA-390450 5.436767e-02 1.265 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 5.436767e-02 1.265 0 0
Signaling by SCF-KIT R-HSA-1433557 5.438018e-02 1.265 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 5.440918e-02 1.264 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 5.440918e-02 1.264 0 0
Long-term potentiation R-HSA-9620244 5.440918e-02 1.264 0 0
DNA Repair R-HSA-73894 5.443710e-02 1.264 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 5.767989e-02 1.239 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 6.218744e-02 1.206 0 0
MET promotes cell motility R-HSA-8875878 5.955573e-02 1.225 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 6.627386e-02 1.179 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 6.626543e-02 1.179 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 6.606282e-02 1.180 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 6.606282e-02 1.180 0 0
DNA strand elongation R-HSA-69190 5.778532e-02 1.238 0 0
Diseases of mitotic cell cycle R-HSA-9675126 5.778532e-02 1.238 0 0
Epigenetic regulation of gene expression R-HSA-212165 6.349039e-02 1.197 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 5.767989e-02 1.239 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.203001e-02 1.207 0 0
G2/M DNA damage checkpoint R-HSA-69473 6.702070e-02 1.174 0 0
Adherens junctions interactions R-HSA-418990 6.650391e-02 1.177 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.759936e-02 1.170 0 0
Signaling by NTRKs R-HSA-166520 6.586689e-02 1.181 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 5.855915e-02 1.232 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.647502e-02 1.177 0 0
PECAM1 interactions R-HSA-210990 6.739331e-02 1.171 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 6.627386e-02 1.179 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 5.767989e-02 1.239 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.767989e-02 1.239 0 0
Cell-cell junction organization R-HSA-421270 6.804983e-02 1.167 0 0
Prolonged ERK activation events R-HSA-169893 6.849568e-02 1.164 0 0
Intracellular signaling by second messengers R-HSA-9006925 6.932164e-02 1.159 1 0
Cellular Senescence R-HSA-2559583 7.017669e-02 1.154 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 7.051284e-02 1.152 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 7.051284e-02 1.152 0 0
Interaction between L1 and Ankyrins R-HSA-445095 7.060959e-02 1.151 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.060959e-02 1.151 0 0
Meiotic synapsis R-HSA-1221632 7.212302e-02 1.142 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 7.278762e-02 1.138 0 0
Signaling by TGFBR3 R-HSA-9839373 7.311809e-02 1.136 0 0
Generation of second messenger molecules R-HSA-202433 7.345018e-02 1.134 0 0
Aggrephagy R-HSA-9646399 7.345018e-02 1.134 0 0
Ub-specific processing proteases R-HSA-5689880 7.357008e-02 1.133 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 7.546000e-02 1.122 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 7.598030e-02 1.119 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 7.598030e-02 1.119 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 7.598030e-02 1.119 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 7.598030e-02 1.119 0 0
TCR signaling R-HSA-202403 7.720641e-02 1.112 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 7.729824e-02 1.112 0 0
Developmental Cell Lineages R-HSA-9734767 7.909456e-02 1.102 0 0
HIV elongation arrest and recovery R-HSA-167287 7.967723e-02 1.099 0 0
Pausing and recovery of HIV elongation R-HSA-167290 7.967723e-02 1.099 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 9.588660e-02 1.018 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 9.588660e-02 1.018 0 0
Regulation of PTEN localization R-HSA-8948747 9.588660e-02 1.018 0 0
SOS-mediated signalling R-HSA-112412 9.588660e-02 1.018 0 0
MET activates RAS signaling R-HSA-8851805 9.776287e-02 1.010 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 9.776287e-02 1.010 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 8.035378e-02 1.095 0 0
RAF activation R-HSA-5673000 8.109570e-02 1.091 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 8.109570e-02 1.091 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 9.973428e-02 1.001 0 0
RET signaling R-HSA-8853659 9.932310e-02 1.003 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 8.049658e-02 1.094 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 8.429685e-02 1.074 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 9.776287e-02 1.010 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 9.973428e-02 1.001 0 0
Disorders of Developmental Biology R-HSA-9675151 8.035378e-02 1.095 0 0
DNA Double-Strand Break Repair R-HSA-5693532 8.489290e-02 1.071 0 0
Heme signaling R-HSA-9707616 8.310437e-02 1.080 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 8.035378e-02 1.095 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 9.973428e-02 1.001 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 9.973428e-02 1.001 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 8.362949e-02 1.078 0 0
G2/M Checkpoints R-HSA-69481 9.803249e-02 1.009 0 0
HIV Infection R-HSA-162906 9.641625e-02 1.016 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.108760e-02 1.091 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 9.192239e-02 1.037 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 9.323137e-02 1.030 0 0
G2/M Transition R-HSA-69275 9.210814e-02 1.036 0 0
Activation of BH3-only proteins R-HSA-114452 9.973428e-02 1.001 0 0
Co-stimulation by CD28 R-HSA-389356 8.761164e-02 1.057 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 9.320659e-02 1.031 0 0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892245 9.588660e-02 1.018 0 0
FLT3 Signaling R-HSA-9607240 8.108760e-02 1.091 0 0
XBP1(S) activates chaperone genes R-HSA-381038 9.804635e-02 1.009 0 0
Gene Silencing by RNA R-HSA-211000 1.018950e-01 0.992 0 0
PIP3 activates AKT signaling R-HSA-1257604 1.021841e-01 0.991 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.024924e-01 0.989 0 0
Drug resistance of PDGFR mutants R-HSA-9674415 1.025357e-01 0.989 0 0
PDGFR mutants bind TKIs R-HSA-9674428 1.025357e-01 0.989 0 0
Regorafenib-resistant PDGFR mutants R-HSA-9674403 1.025357e-01 0.989 0 0
Deletions in the AMER1 gene destabilize the destruction complex R-HSA-5467343 1.025357e-01 0.989 0 0
Imatinib-resistant PDGFR mutants R-HSA-9674396 1.025357e-01 0.989 0 0
Sunitinib-resistant PDGFR mutants R-HSA-9674401 1.025357e-01 0.989 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 1.025357e-01 0.989 0 0
Sorafenib-resistant PDGFR mutants R-HSA-9674404 1.025357e-01 0.989 0 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 1.028264e-01 0.988 0 0
Signaling by FGFR4 R-HSA-5654743 1.067641e-01 0.972 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 1.070955e-01 0.970 0 0
GAB1 signalosome R-HSA-180292 1.070955e-01 0.970 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.070955e-01 0.970 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.070955e-01 0.970 0 0
MHC class II antigen presentation R-HSA-2132295 1.140653e-01 0.943 0 0
Formation of axial mesoderm R-HSA-9796292 1.149601e-01 0.939 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.149601e-01 0.939 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 1.149601e-01 0.939 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 1.149601e-01 0.939 0 0
Netrin-1 signaling R-HSA-373752 1.162332e-01 0.935 0 0
Gap junction trafficking R-HSA-190828 1.162332e-01 0.935 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 1.162332e-01 0.935 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 1.182843e-01 0.927 0 0
Type I hemidesmosome assembly R-HSA-446107 1.182843e-01 0.927 0 0
Host Interactions of HIV factors R-HSA-162909 1.198829e-01 0.921 0 0
mRNA 3'-end processing R-HSA-72187 1.214200e-01 0.916 0 0
Regulation of signaling by CBL R-HSA-912631 1.219040e-01 0.914 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 1.219040e-01 0.914 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 1.219040e-01 0.914 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.221268e-01 0.913 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 1.221268e-01 0.913 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 1.222887e-01 0.913 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.945633e-01 0.711 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.945633e-01 0.711 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.945633e-01 0.711 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.945633e-01 0.711 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.945633e-01 0.711 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.945633e-01 0.711 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.945633e-01 0.711 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.945633e-01 0.711 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.945633e-01 0.711 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.382873e-01 0.859 0 0
Regulation of gap junction activity R-HSA-191650 1.382873e-01 0.859 0 0
Inhibition of TSC complex formation by PKB R-HSA-165181 1.382873e-01 0.859 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.382873e-01 0.859 0 0
RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 1.382873e-01 0.859 0 0
Signaling by TCF7L2 mutants R-HSA-5339700 2.771590e-01 0.557 0 0
Defective TPMT causes TPMT deficiency R-HSA-5578995 2.771590e-01 0.557 0 0
Defective SLC6A2 causes orthostatic intolerance (OI) R-HSA-5619109 2.771590e-01 0.557 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.771590e-01 0.557 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 2.771590e-01 0.557 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.771590e-01 0.557 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 2.771590e-01 0.557 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 1.759114e-01 0.755 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 1.759114e-01 0.755 0 0
Post-transcriptional silencing by small RNAs R-HSA-426496 1.759114e-01 0.755 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 1.759114e-01 0.755 0 0
G2 Phase R-HSA-68911 1.759114e-01 0.755 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 1.759114e-01 0.755 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.423999e-01 0.846 0 0
PKB-mediated events R-HSA-109703 2.148828e-01 0.668 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 2.148828e-01 0.668 0 0
PDE3B signalling R-HSA-165160 2.148828e-01 0.668 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 3.512891e-01 0.454 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 3.512891e-01 0.454 0 0
Interaction between PHLDA1 and AURKA R-HSA-8854521 3.512891e-01 0.454 0 0
Regulation of cortical dendrite branching R-HSA-8985801 3.512891e-01 0.454 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 3.512891e-01 0.454 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 3.512891e-01 0.454 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 3.512891e-01 0.454 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 3.512891e-01 0.454 0 0
Defective ABCB6 causes MCOPCB7 R-HSA-5683371 3.512891e-01 0.454 0 0
Defective SLC6A5 causes hyperekplexia 3 (HKPX3) R-HSA-5619089 3.512891e-01 0.454 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 3.512891e-01 0.454 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 3.512891e-01 0.454 0 0
Signaling by RAS GAP mutants R-HSA-9753510 3.512891e-01 0.454 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 3.512891e-01 0.454 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 3.512891e-01 0.454 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 3.512891e-01 0.454 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 3.512891e-01 0.454 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 3.512891e-01 0.454 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 3.512891e-01 0.454 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.679740e-01 0.775 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 1.679740e-01 0.775 0 0
Signaling by LTK in cancer R-HSA-9842640 2.545302e-01 0.594 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.545302e-01 0.594 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.545302e-01 0.594 0 0
Branched-chain ketoacid dehydrogenase kinase deficiency R-HSA-9912481 2.545302e-01 0.594 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.947485e-01 0.711 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.947485e-01 0.711 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 1.529046e-01 0.816 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 1.529046e-01 0.816 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 1.376071e-01 0.861 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 1.376071e-01 0.861 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 1.376071e-01 0.861 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 1.376071e-01 0.861 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 1.376071e-01 0.861 0 0
Phosphorylation of the APC/C R-HSA-176412 1.734318e-01 0.761 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 1.734318e-01 0.761 0 0
Activation of RAC1 R-HSA-428540 2.224729e-01 0.653 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 2.224729e-01 0.653 0 0
Signaling by AMER1 mutants R-HSA-4839748 2.224729e-01 0.653 0 0
Signaling by GSK3beta mutants R-HSA-5339716 2.224729e-01 0.653 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.943056e-01 0.531 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.943056e-01 0.531 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 2.943056e-01 0.531 0 0
Activated NTRK3 signals through PLCG1 R-HSA-9034793 4.178208e-01 0.379 0 0
PLC-gamma1 signalling R-HSA-167021 4.178208e-01 0.379 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 4.178208e-01 0.379 0 0
Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 4.178208e-01 0.379 0 0
MET activates PTPN11 R-HSA-8865999 4.178208e-01 0.379 0 0
Defective SLC7A7 causes lysinuric protein intolerance (LPI) R-HSA-5660862 4.178208e-01 0.379 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 1.541481e-01 0.812 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 2.509083e-01 0.600 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 2.509083e-01 0.600 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 2.509083e-01 0.600 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 2.509083e-01 0.600 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 2.509083e-01 0.600 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 2.509083e-01 0.600 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 2.509083e-01 0.600 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 2.509083e-01 0.600 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 2.509083e-01 0.600 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.515612e-01 0.819 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.337661e-01 0.477 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.337661e-01 0.477 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 3.337661e-01 0.477 0 0
MET receptor recycling R-HSA-8875656 3.337661e-01 0.477 0 0
Regulation of NPAS4 mRNA translation R-HSA-9768778 3.337661e-01 0.477 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 3.337661e-01 0.477 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 3.337661e-01 0.477 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 1.894897e-01 0.722 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 2.798304e-01 0.553 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 2.798304e-01 0.553 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.398067e-01 0.620 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 2.398067e-01 0.620 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 1.822229e-01 0.739 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 1.984068e-01 0.702 0 0
Activation of the pre-replicative complex R-HSA-68962 1.984068e-01 0.702 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 1.984068e-01 0.702 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.273835e-01 0.643 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.631251e-01 0.580 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 2.631251e-01 0.580 0 0
NRIF signals cell death from the nucleus R-HSA-205043 3.090315e-01 0.510 0 0
Regulation of CDH1 mRNA translation by microRNAs R-HSA-9764562 3.090315e-01 0.510 0 0
WNT mediated activation of DVL R-HSA-201688 3.725583e-01 0.429 0 0
Calcineurin activates NFAT R-HSA-2025928 3.725583e-01 0.429 0 0
ALK mutants bind TKIs R-HSA-9700645 3.725583e-01 0.429 0 0
Activated NTRK2 signals through PLCG1 R-HSA-9026527 4.775325e-01 0.321 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.775325e-01 0.321 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 4.775325e-01 0.321 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 4.775325e-01 0.321 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.308567e-01 0.883 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 2.471058e-01 0.607 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 2.868417e-01 0.542 0 0
Erythropoietin activates RAS R-HSA-9027284 3.383220e-01 0.471 0 0
Processive synthesis on the lagging strand R-HSA-69183 3.383220e-01 0.471 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 3.383220e-01 0.471 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 3.383220e-01 0.471 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 3.383220e-01 0.471 0 0
p38MAPK events R-HSA-171007 3.383220e-01 0.471 0 0
SHC1 events in EGFR signaling R-HSA-180336 3.383220e-01 0.471 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 3.383220e-01 0.471 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 1.614149e-01 0.792 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 2.672461e-01 0.573 0 0
MET activates PTK2 signaling R-HSA-8874081 2.672461e-01 0.573 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.819957e-01 0.740 0 0
Lagging Strand Synthesis R-HSA-69186 3.108430e-01 0.507 0 0
Signalling to RAS R-HSA-167044 3.108430e-01 0.507 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.104044e-01 0.387 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 4.104044e-01 0.387 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 2.877303e-01 0.541 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 2.877303e-01 0.541 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 2.877303e-01 0.541 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.468242e-01 0.833 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 2.069907e-01 0.684 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 3.675303e-01 0.435 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 3.675303e-01 0.435 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.951163e-01 0.710 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 2.500590e-01 0.602 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 2.342605e-01 0.630 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 3.350203e-01 0.475 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 2.199853e-01 0.658 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 3.084853e-01 0.511 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 2.859402e-01 0.544 0 0
Chaperonin-mediated protein folding R-HSA-390466 1.645715e-01 0.784 0 0
Signaling by Erythropoietin R-HSA-9006335 3.294399e-01 0.482 0 0
Termination of translesion DNA synthesis R-HSA-5656169 3.294399e-01 0.482 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.294399e-01 0.482 0 0
FGFR2 alternative splicing R-HSA-6803529 3.592708e-01 0.445 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 3.592708e-01 0.445 0 0
Regulation of CDH11 mRNA translation by microRNAs R-HSA-9759811 4.470906e-01 0.350 0 0
Signaling by APC mutants R-HSA-4839744 4.470906e-01 0.350 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 4.470906e-01 0.350 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 4.470906e-01 0.350 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 4.470906e-01 0.350 0 0
RUNX2 regulates bone development R-HSA-8941326 3.230949e-01 0.491 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 3.230949e-01 0.491 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 3.834982e-01 0.416 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 3.834982e-01 0.416 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 3.834982e-01 0.416 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.890723e-01 0.539 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 4.251068e-01 0.372 0 0
Deadenylation of mRNA R-HSA-429947 4.076131e-01 0.390 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 4.824568e-01 0.317 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 4.824568e-01 0.317 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 4.824568e-01 0.317 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.824568e-01 0.317 0 0
Regulation of PTEN stability and activity R-HSA-8948751 3.416429e-01 0.466 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.416429e-01 0.466 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 4.532224e-01 0.344 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 4.532224e-01 0.344 0 0
Tight junction interactions R-HSA-420029 4.315332e-01 0.365 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.348710e-01 0.475 0 0
Germ layer formation at gastrulation R-HSA-9754189 4.807495e-01 0.318 0 0
Dual Incision in GG-NER R-HSA-5696400 4.556837e-01 0.341 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 4.221479e-01 0.375 0 0
Dual incision in TC-NER R-HSA-6782135 4.221479e-01 0.375 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 4.221479e-01 0.375 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 4.384229e-01 0.358 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 4.721581e-01 0.326 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.721581e-01 0.326 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.891654e-01 0.311 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.891654e-01 0.311 0 0
Signaling by EGFR in Cancer R-HSA-1643713 1.371692e-01 0.863 0 0
PKR-mediated signaling R-HSA-9833482 4.809207e-01 0.318 0 0
RNA Polymerase III Transcription R-HSA-74158 3.230949e-01 0.491 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 1.455707e-01 0.837 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.735649e-01 0.761 0 0
IGF1R signaling cascade R-HSA-2428924 1.632580e-01 0.787 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.613717e-01 0.583 0 0
Downstream signal transduction R-HSA-186763 2.150978e-01 0.667 0 0
COPII-mediated vesicle transport R-HSA-204005 4.684916e-01 0.329 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.471058e-01 0.607 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.505247e-01 0.455 0 0
Chromosome Maintenance R-HSA-73886 2.978774e-01 0.526 0 0
Insulin receptor signalling cascade R-HSA-74751 3.779418e-01 0.423 0 0
HCMV Early Events R-HSA-9609690 3.105521e-01 0.508 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 3.530388e-01 0.452 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 4.702757e-01 0.328 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 1.822229e-01 0.739 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 1.984068e-01 0.702 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 3.044157e-01 0.517 0 0
DNA Damage Bypass R-HSA-73893 1.700339e-01 0.769 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 1.894897e-01 0.722 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 3.350203e-01 0.475 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 4.384229e-01 0.358 0 0
Protein folding R-HSA-391251 2.213041e-01 0.655 0 0
Extension of Telomeres R-HSA-180786 4.382573e-01 0.358 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 2.672461e-01 0.573 0 0
G0 and Early G1 R-HSA-1538133 3.928217e-01 0.406 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 3.044157e-01 0.517 0 0
HSF1-dependent transactivation R-HSA-3371571 3.099847e-01 0.509 0 0
DNA Double Strand Break Response R-HSA-5693606 2.972806e-01 0.527 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 2.868417e-01 0.542 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.104044e-01 0.387 0 0
Synthesis of PIPs at the late endosome membrane R-HSA-1660517 4.251068e-01 0.372 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 2.086535e-01 0.681 0 0
Frs2-mediated activation R-HSA-170968 2.798304e-01 0.553 0 0
Pexophagy R-HSA-9664873 4.104044e-01 0.387 0 0
Metalloprotease DUBs R-HSA-5689901 2.672461e-01 0.573 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.104044e-01 0.387 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 4.367370e-01 0.360 0 0
DAP12 signaling R-HSA-2424491 1.984068e-01 0.702 0 0
Regulation of endogenous retroelements R-HSA-9842860 3.420417e-01 0.466 0 0
Neurodegenerative Diseases R-HSA-8863678 2.273835e-01 0.643 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 2.273835e-01 0.643 0 0
Leishmania phagocytosis R-HSA-9664417 4.344321e-01 0.362 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.344321e-01 0.362 0 0
Parasite infection R-HSA-9664407 4.344321e-01 0.362 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 1.759114e-01 0.755 0 0
PI3K/AKT activation R-HSA-198203 1.679740e-01 0.775 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 2.943056e-01 0.531 0 0
G-protein beta:gamma signalling R-HSA-397795 2.498046e-01 0.602 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 2.500590e-01 0.602 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.350203e-01 0.475 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 3.592708e-01 0.445 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 3.965036e-01 0.402 0 0
Oncogene Induced Senescence R-HSA-2559585 1.743155e-01 0.759 0 0
Myogenesis R-HSA-525793 1.371692e-01 0.863 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 2.859402e-01 0.544 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 3.185447e-01 0.497 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.859402e-01 0.544 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.393622e-01 0.856 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.134307e-01 0.384 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 1.382873e-01 0.859 0 0
Netrin mediated repulsion signals R-HSA-418886 2.943056e-01 0.531 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 1.948388e-01 0.710 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 3.725583e-01 0.429 0 0
TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8866911 4.775325e-01 0.321 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 1.342561e-01 0.872 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 2.877303e-01 0.541 0 0
Trafficking of AMPA receptors R-HSA-399719 3.716731e-01 0.430 0 0
NF-kB is activated and signals survival R-HSA-209560 4.824568e-01 0.317 0 0
Signaling by PDGF R-HSA-186797 4.861368e-01 0.313 0 0
Synthesis of DNA R-HSA-69239 3.115716e-01 0.506 0 0
Signaling by FGFR2 R-HSA-5654738 1.646621e-01 0.783 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 4.824568e-01 0.317 0 0
Stabilization of p53 R-HSA-69541 3.798599e-01 0.420 0 0
Signaling by FGFR R-HSA-190236 4.001184e-01 0.398 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.903112e-01 0.409 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.204165e-01 0.376 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 2.877303e-01 0.541 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.413500e-01 0.617 0 0
Integration of provirus R-HSA-162592 4.824568e-01 0.317 0 0
Signaling by FGFR3 R-HSA-5654741 1.261468e-01 0.899 0 0
Synthesis of PIPs at the early endosome membrane R-HSA-1660516 2.471058e-01 0.607 0 0
Resolution of D-Loop Structures R-HSA-5693537 4.348817e-01 0.362 0 0
Signaling by WNT in cancer R-HSA-4791275 3.928217e-01 0.406 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.663092e-01 0.779 0 0
RNA Polymerase II Transcription R-HSA-73857 1.568077e-01 0.805 0 0
Generic Transcription Pathway R-HSA-212436 2.242051e-01 0.649 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 1.759114e-01 0.755 0 0
Signaling by FGFR4 in disease R-HSA-5655291 1.333761e-01 0.875 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 2.170045e-01 0.664 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 3.090315e-01 0.510 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 3.090315e-01 0.510 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 2.868417e-01 0.542 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 3.383220e-01 0.471 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 3.383220e-01 0.471 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.498046e-01 0.602 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 3.108430e-01 0.507 0 0
Synthesis of PI R-HSA-1483226 4.470906e-01 0.350 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.995750e-01 0.523 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 4.139101e-01 0.383 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 4.139101e-01 0.383 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.080376e-01 0.511 0 0
Homology Directed Repair R-HSA-5693538 2.681077e-01 0.572 0 0
Circadian clock R-HSA-9909396 3.412024e-01 0.467 0 0
Ion homeostasis R-HSA-5578775 2.607050e-01 0.584 0 0
TBC/RABGAPs R-HSA-8854214 3.165334e-01 0.500 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 3.926567e-01 0.406 0 0
Meiosis R-HSA-1500620 1.393622e-01 0.856 0 0
Signaling by FGFR1 R-HSA-5654736 2.607050e-01 0.584 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 4.315332e-01 0.365 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 3.420417e-01 0.466 0 0
Signaling by ROBO receptors R-HSA-376176 4.472763e-01 0.349 0 0
p75NTR signals via NF-kB R-HSA-193639 1.529046e-01 0.816 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 1.371692e-01 0.863 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 1.743155e-01 0.759 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.592708e-01 0.445 0 0
Lipophagy R-HSA-9613354 1.423999e-01 0.846 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 2.148828e-01 0.668 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.337661e-01 0.477 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 3.090315e-01 0.510 0 0
Co-inhibition by CTLA4 R-HSA-389513 2.868417e-01 0.542 0 0
HDACs deacetylate histones R-HSA-3214815 2.468646e-01 0.608 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.658861e-01 0.575 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 4.551835e-01 0.342 0 0
Cilium Assembly R-HSA-5617833 4.122928e-01 0.385 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.923397e-01 0.716 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.398067e-01 0.620 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 2.471058e-01 0.607 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 1.642728e-01 0.784 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 2.545302e-01 0.594 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 2.545302e-01 0.594 0 0
Rap1 signalling R-HSA-392517 2.631251e-01 0.580 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.109857e-01 0.507 0 0
FGFR1 mutant receptor activation R-HSA-1839124 4.139101e-01 0.383 0 0
p75NTR recruits signalling complexes R-HSA-209543 2.509083e-01 0.600 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.725583e-01 0.429 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.435946e-01 0.843 0 0
Ca2+ pathway R-HSA-4086398 1.740546e-01 0.759 0 0
Signaling by FGFR in disease R-HSA-1226099 2.784505e-01 0.555 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.250239e-01 0.648 0 0
Spry regulation of FGF signaling R-HSA-1295596 3.383220e-01 0.471 0 0
Interferon Signaling R-HSA-913531 2.750670e-01 0.561 0 0
HATs acetylate histones R-HSA-3214847 1.476608e-01 0.831 0 0
G alpha (12/13) signalling events R-HSA-416482 3.303005e-01 0.481 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 3.528766e-01 0.452 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.941126e-01 0.531 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.945633e-01 0.711 0 0
Inhibition of PKR R-HSA-169131 1.945633e-01 0.711 0 0
mRNA Editing: A to I Conversion R-HSA-75064 3.512891e-01 0.454 0 0
Neurophilin interactions with VEGF and VEGFR R-HSA-194306 3.512891e-01 0.454 0 0
C6 deamination of adenosine R-HSA-75102 3.512891e-01 0.454 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 3.512891e-01 0.454 0 0
Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 1.679740e-01 0.775 0 0
Regulation of KIT signaling R-HSA-1433559 1.333761e-01 0.875 0 0
CREB phosphorylation R-HSA-199920 2.545302e-01 0.594 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.545302e-01 0.594 0 0
Bicarbonate transporters R-HSA-425381 1.947485e-01 0.711 0 0
Negative regulation of FLT3 R-HSA-9706369 1.734318e-01 0.761 0 0
MET activates STAT3 R-HSA-8875791 4.178208e-01 0.379 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 3.337661e-01 0.477 0 0
Co-stimulation by ICOS R-HSA-9927354 3.337661e-01 0.477 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 2.798304e-01 0.553 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 2.798304e-01 0.553 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.725583e-01 0.429 0 0
Degradation of CDH1 R-HSA-9766229 1.700339e-01 0.769 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.104044e-01 0.387 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.104044e-01 0.387 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.859402e-01 0.544 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 2.488958e-01 0.604 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.294399e-01 0.482 0 0
Ionotropic activity of kainate receptors R-HSA-451306 4.470906e-01 0.350 0 0
Signaling by AXIN mutants R-HSA-4839735 4.824568e-01 0.317 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.478835e-01 0.459 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 4.807495e-01 0.318 0 0
Response of endothelial cells to shear stress R-HSA-9860931 3.654812e-01 0.437 0 0
Signaling by FGFR3 in disease R-HSA-5655332 4.784962e-01 0.320 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 1.791163e-01 0.747 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 4.551835e-01 0.342 0 0
Muscle contraction R-HSA-397014 1.858842e-01 0.731 0 0
Cellular responses to stress R-HSA-2262752 4.134943e-01 0.384 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 1.539407e-01 0.813 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 2.379649e-01 0.623 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 3.965036e-01 0.402 0 0
Cellular responses to stimuli R-HSA-8953897 4.086405e-01 0.389 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.328366e-01 0.877 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 2.170045e-01 0.664 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 4.807495e-01 0.318 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.662996e-01 0.575 0 0
Smooth Muscle Contraction R-HSA-445355 2.199853e-01 0.658 0 0
Early Phase of HIV Life Cycle R-HSA-162594 3.108430e-01 0.507 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.245643e-01 0.372 0 0
Signaling by ERBB4 R-HSA-1236394 2.784505e-01 0.555 0 0
TNF signaling R-HSA-75893 2.607050e-01 0.584 0 0
Ion transport by P-type ATPases R-HSA-936837 1.632580e-01 0.787 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.294097e-01 0.639 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 2.148828e-01 0.668 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 2.170045e-01 0.664 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 3.725583e-01 0.429 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 3.725583e-01 0.429 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 4.775325e-01 0.321 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.877303e-01 0.541 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.608653e-01 0.443 0 0
GPER1 signaling R-HSA-9634597 4.030288e-01 0.395 0 0
Signaling by FGFR2 in disease R-HSA-5655253 4.377546e-01 0.359 0 0
Signaling by KIT in disease R-HSA-9669938 1.894897e-01 0.722 0 0
Sensory processing of sound R-HSA-9659379 4.667938e-01 0.331 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 2.509083e-01 0.600 0 0
Signaling by TGFB family members R-HSA-9006936 2.234308e-01 0.651 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 4.551835e-01 0.342 0 0
Formation of the ureteric bud R-HSA-9830674 3.834982e-01 0.416 0 0
Mismatch Repair R-HSA-5358508 2.398067e-01 0.620 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 3.988658e-01 0.399 0 0
NCAM signaling for neurite out-growth R-HSA-375165 4.861368e-01 0.313 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.584529e-01 0.800 0 0
MAP kinase activation R-HSA-450294 4.702757e-01 0.328 0 0
Inhibition of membrane repair R-HSA-9635644 2.771590e-01 0.557 0 0
DSCAM interactions R-HSA-376172 3.512891e-01 0.454 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.545302e-01 0.594 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.725583e-01 0.429 0 0
TNFR1-mediated ceramide production R-HSA-5626978 4.775325e-01 0.321 0 0
NADE modulates death signalling R-HSA-205025 4.775325e-01 0.321 0 0
2-LTR circle formation R-HSA-164843 4.104044e-01 0.387 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 2.677195e-01 0.572 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.419277e-01 0.466 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 4.824568e-01 0.317 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 4.824568e-01 0.317 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 4.139101e-01 0.383 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 4.139101e-01 0.383 0 0
Potential therapeutics for SARS R-HSA-9679191 3.641940e-01 0.439 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 4.784962e-01 0.320 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 3.505247e-01 0.455 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 4.784962e-01 0.320 0 0
Basigin interactions R-HSA-210991 3.108430e-01 0.507 0 0
Reproduction R-HSA-1474165 4.135215e-01 0.384 0 0
FLT3 signaling in disease R-HSA-9682385 1.886174e-01 0.724 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 2.545302e-01 0.594 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.344639e-01 0.871 0 0
NRAGE signals death through JNK R-HSA-193648 1.614149e-01 0.792 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.747821e-01 0.561 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 2.681077e-01 0.572 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 4.762669e-01 0.322 0 0
SARS-CoV-2-host interactions R-HSA-9705683 2.326758e-01 0.633 0 0
PLC beta mediated events R-HSA-112043 4.702757e-01 0.328 1 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.684916e-01 0.329 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.948388e-01 0.710 0 0
Signal transduction by L1 R-HSA-445144 1.376071e-01 0.861 0 0
NGF-stimulated transcription R-HSA-9031628 2.638152e-01 0.579 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 3.898558e-01 0.409 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.948388e-01 0.710 0 0
Sodium/Proton exchangers R-HSA-425986 3.337661e-01 0.477 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.341337e-01 0.631 0 0
DAG and IP3 signaling R-HSA-1489509 3.509016e-01 0.455 1 0
Synaptic adhesion-like molecules R-HSA-8849932 4.532224e-01 0.344 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 3.898558e-01 0.409 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 3.675303e-01 0.435 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 3.730102e-01 0.428 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.679740e-01 0.775 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.177185e-01 0.379 0 0
Tie2 Signaling R-HSA-210993 4.532224e-01 0.344 0 0
Interleukin-2 signaling R-HSA-9020558 4.470906e-01 0.350 0 0
CHL1 interactions R-HSA-447041 2.943056e-01 0.531 0 0
Syndecan interactions R-HSA-3000170 2.081535e-01 0.682 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 2.185610e-01 0.660 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 4.470906e-01 0.350 0 0
Regulation of beta-cell development R-HSA-186712 3.035517e-01 0.518 0 0
Gap junction assembly R-HSA-190861 4.556837e-01 0.341 0 0
Glycolysis R-HSA-70171 3.189271e-01 0.496 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 4.721581e-01 0.326 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 4.556837e-01 0.341 0 0
Josephin domain DUBs R-HSA-5689877 4.104044e-01 0.387 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 3.675303e-01 0.435 0 0
Specification of primordial germ cells R-HSA-9827857 4.251068e-01 0.372 0 0
IRE1alpha activates chaperones R-HSA-381070 1.399397e-01 0.854 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.714645e-01 0.766 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 4.139101e-01 0.383 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 4.303085e-01 0.366 0 0
Signaling by Leptin R-HSA-2586552 4.104044e-01 0.387 0 0
Interleukin-7 signaling R-HSA-1266695 4.315332e-01 0.365 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 4.892804e-01 0.310 0 0
DAP12 interactions R-HSA-2172127 4.925958e-01 0.308 0 0
HSF1 activation R-HSA-3371511 4.965862e-01 0.304 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 4.982274e-01 0.303 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.982274e-01 0.303 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 4.989958e-01 0.302 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.014108e-01 0.300 0 0
Formation of the Early Elongation Complex R-HSA-113418 5.014108e-01 0.300 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 5.014108e-01 0.300 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 5.014108e-01 0.300 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 5.014108e-01 0.300 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.018692e-01 0.299 0 0
Signaling by PTK6 R-HSA-8848021 5.018692e-01 0.299 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 5.021264e-01 0.299 0 0
Translation initiation complex formation R-HSA-72649 5.060071e-01 0.296 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.076025e-01 0.294 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.076025e-01 0.294 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 5.108200e-01 0.292 0 0
Nucleosome assembly R-HSA-774815 5.108200e-01 0.292 0 0
SARS-CoV-1-host interactions R-HSA-9692914 5.111645e-01 0.291 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 5.144352e-01 0.289 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 5.162147e-01 0.287 0 0
TCF dependent signaling in response to WNT R-HSA-201681 5.162427e-01 0.287 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 5.163879e-01 0.287 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.163879e-01 0.287 0 0
Polymerase switching R-HSA-69091 5.163879e-01 0.287 0 0
Leading Strand Synthesis R-HSA-69109 5.163879e-01 0.287 0 0
VLDLR internalisation and degradation R-HSA-8866427 5.163879e-01 0.287 0 0
Regulation of IFNG signaling R-HSA-877312 5.163879e-01 0.287 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.163879e-01 0.287 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 5.163879e-01 0.287 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.163879e-01 0.287 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 5.163879e-01 0.287 0 0
OAS antiviral response R-HSA-8983711 5.163879e-01 0.287 0 0
Ovarian tumor domain proteases R-HSA-5689896 5.166006e-01 0.287 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.226582e-01 0.282 0 0
Signaling by NOTCH3 R-HSA-9012852 5.226582e-01 0.282 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.226582e-01 0.282 0 0
Cytoprotection by HMOX1 R-HSA-9707564 5.227432e-01 0.282 0 0
Late endosomal microautophagy R-HSA-9615710 5.238737e-01 0.281 0 0
mRNA Capping R-HSA-72086 5.238737e-01 0.281 0 0
DARPP-32 events R-HSA-180024 5.238737e-01 0.281 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 5.238737e-01 0.281 0 0
Platelet calcium homeostasis R-HSA-418360 5.238737e-01 0.281 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 5.238737e-01 0.281 0 0
Adipogenesis R-HSA-9843745 5.239413e-01 0.281 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 5.274828e-01 0.278 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.287942e-01 0.277 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.287942e-01 0.277 0 0
Regulation of TNFR1 signaling R-HSA-5357905 5.287942e-01 0.277 0 0
Diseases of DNA repair R-HSA-9675135 5.287942e-01 0.277 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 5.311230e-01 0.275 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 5.311230e-01 0.275 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 5.311230e-01 0.275 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.311230e-01 0.275 0 0
Activation of AKT2 R-HSA-165158 5.311230e-01 0.275 0 0
Reelin signalling pathway R-HSA-8866376 5.311230e-01 0.275 0 0
Muscarinic acetylcholine receptors R-HSA-390648 5.311230e-01 0.275 0 0
Inositol transporters R-HSA-429593 5.311230e-01 0.275 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 5.311230e-01 0.275 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 5.311230e-01 0.275 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 5.337107e-01 0.273 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 5.337107e-01 0.273 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 5.337107e-01 0.273 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 5.337107e-01 0.273 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.362729e-01 0.271 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.390956e-01 0.268 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 5.390956e-01 0.268 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 5.390956e-01 0.268 0 0
Hedgehog 'off' state R-HSA-5610787 5.396958e-01 0.268 0 0
HCMV Infection R-HSA-9609646 5.407706e-01 0.267 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.464906e-01 0.262 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 5.480901e-01 0.261 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 5.488064e-01 0.261 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.488064e-01 0.261 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 5.488064e-01 0.261 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 5.488064e-01 0.261 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.488064e-01 0.261 0 0
Glucose metabolism R-HSA-70326 5.541028e-01 0.256 0 0
IRS-mediated signalling R-HSA-112399 5.552976e-01 0.255 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 5.555697e-01 0.255 0 0
UCH proteinases R-HSA-5689603 5.561247e-01 0.255 0 0
Signaling by NOTCH1 R-HSA-1980143 5.561247e-01 0.255 0 0
Assembly of the pre-replicative complex R-HSA-68867 5.574278e-01 0.254 0 0
MyD88-independent TLR4 cascade R-HSA-166166 5.589585e-01 0.253 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 5.589585e-01 0.253 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 5.590165e-01 0.253 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.631098e-01 0.249 0 0
G-protein mediated events R-HSA-112040 5.631098e-01 0.249 1 0
Kidney development R-HSA-9830369 5.631098e-01 0.249 0 0
Cargo concentration in the ER R-HSA-5694530 5.672644e-01 0.246 0 0
Budding and maturation of HIV virion R-HSA-162588 5.672644e-01 0.246 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 5.744614e-01 0.241 0 0
HIV Transcription Elongation R-HSA-167169 5.744614e-01 0.241 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.744614e-01 0.241 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.766112e-01 0.239 0 0
Transcription of the HIV genome R-HSA-167172 5.779082e-01 0.238 0 0
RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.792195e-01 0.237 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.792195e-01 0.237 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.792195e-01 0.237 0 0
CDC6 association with the ORC:origin complex R-HSA-68689 5.792195e-01 0.237 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.792195e-01 0.237 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.792195e-01 0.237 0 0
Loss-of-function mutations in DBT cause MSUD2 R-HSA-9865113 5.792195e-01 0.237 0 0
Signaling by MAPK mutants R-HSA-9652817 5.792195e-01 0.237 0 0
Loss-of-function mutations in DLD cause MSUD3/DLDD R-HSA-9907570 5.792195e-01 0.237 0 0
Terminal pathway of complement R-HSA-166665 5.792195e-01 0.237 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.792195e-01 0.237 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.792195e-01 0.237 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 5.792195e-01 0.237 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.792195e-01 0.237 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.792195e-01 0.237 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 5.792195e-01 0.237 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.792195e-01 0.237 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.792195e-01 0.237 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 5.792195e-01 0.237 0 0
Removal of the Flap Intermediate R-HSA-69166 5.796654e-01 0.237 0 0
Retrograde neurotrophin signalling R-HSA-177504 5.796654e-01 0.237 0 0
CRMPs in Sema3A signaling R-HSA-399956 5.796654e-01 0.237 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.796654e-01 0.237 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 5.796654e-01 0.237 0 0
Zinc transporters R-HSA-435354 5.796654e-01 0.237 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 5.809525e-01 0.236 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 5.809525e-01 0.236 0 0
LDL clearance R-HSA-8964038 5.834745e-01 0.234 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 5.834745e-01 0.234 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 5.834745e-01 0.234 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 5.869184e-01 0.231 0 0
Opioid Signalling R-HSA-111885 5.883193e-01 0.230 1 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 5.929224e-01 0.227 0 0
PI3K Cascade R-HSA-109704 5.976750e-01 0.224 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 6.023029e-01 0.220 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 6.023029e-01 0.220 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 6.023029e-01 0.220 0 0
Adaptive Immune System R-HSA-1280218 6.060376e-01 0.218 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 6.067832e-01 0.217 0 0
Interleukin-17 signaling R-HSA-448424 6.067832e-01 0.217 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.067832e-01 0.217 0 0
Interleukin receptor SHC signaling R-HSA-912526 6.070504e-01 0.217 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 6.083710e-01 0.216 0 0
Cardiogenesis R-HSA-9733709 6.083710e-01 0.216 0 0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation R-HSA-8948700 6.089439e-01 0.215 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 6.089439e-01 0.215 0 0
Translesion synthesis by REV1 R-HSA-110312 6.089439e-01 0.215 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 6.089439e-01 0.215 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 6.089439e-01 0.215 0 0
Protein methylation R-HSA-8876725 6.089439e-01 0.215 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 6.089439e-01 0.215 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 6.106066e-01 0.214 0 0
Negative regulation of MAPK pathway R-HSA-5675221 6.109303e-01 0.214 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.180560e-01 0.209 0 0
Signaling by WNT R-HSA-195721 6.188302e-01 0.208 0 0
Telomere Maintenance R-HSA-157579 6.193402e-01 0.208 0 0
SLC transporter disorders R-HSA-5619102 6.206595e-01 0.207 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.208341e-01 0.207 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.208341e-01 0.207 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 6.220989e-01 0.206 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 6.223848e-01 0.206 0 0
Small interfering RNA (siRNA) biogenesis R-HSA-426486 6.223848e-01 0.206 0 0
Chylomicron clearance R-HSA-8964026 6.223848e-01 0.206 0 0
RUNX1 regulates transcription of genes involved in WNT signaling R-HSA-8939256 6.223848e-01 0.206 0 0
Erythropoietin activates STAT5 R-HSA-9027283 6.223848e-01 0.206 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 6.223848e-01 0.206 0 0
Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD R-HSA-9865125 6.223848e-01 0.206 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 6.223848e-01 0.206 0 0
H139Hfs13* PPM1K causes a mild variant of MSUD R-HSA-9912529 6.223848e-01 0.206 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 6.223848e-01 0.206 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 6.223848e-01 0.206 0 0
MET Receptor Activation R-HSA-6806942 6.223848e-01 0.206 0 0
Leukotriene receptors R-HSA-391906 6.223848e-01 0.206 0 0
Neurofascin interactions R-HSA-447043 6.223848e-01 0.206 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.297201e-01 0.201 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 6.297201e-01 0.201 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.297201e-01 0.201 0 0
Neurexins and neuroligins R-HSA-6794361 6.300137e-01 0.201 0 0
Orc1 removal from chromatin R-HSA-68949 6.300137e-01 0.201 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 6.321468e-01 0.199 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.346123e-01 0.197 0 0
Translesion synthesis by POLI R-HSA-5656121 6.366413e-01 0.196 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 6.366413e-01 0.196 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 6.366413e-01 0.196 0 0
Killing mechanisms R-HSA-9664420 6.366413e-01 0.196 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 6.366413e-01 0.196 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 6.366413e-01 0.196 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 6.366413e-01 0.196 0 0
Differentiation of T cells R-HSA-9945266 6.366413e-01 0.196 0 0
TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 6.366413e-01 0.196 0 0
FOXO-mediated transcription R-HSA-9614085 6.428567e-01 0.192 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.465818e-01 0.189 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 6.469898e-01 0.189 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 6.469898e-01 0.189 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 6.469898e-01 0.189 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.469898e-01 0.189 0 0
Mitophagy R-HSA-5205647 6.469898e-01 0.189 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 6.469898e-01 0.189 0 0
G1/S Transition R-HSA-69206 6.513881e-01 0.186 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 6.514681e-01 0.186 0 0
Laminin interactions R-HSA-3000157 6.514681e-01 0.186 0 0
Formation of the nephric duct R-HSA-9830364 6.514681e-01 0.186 0 0
tRNA processing R-HSA-72306 6.564789e-01 0.183 0 0
DNA Replication Pre-Initiation R-HSA-69002 6.566549e-01 0.183 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 6.597485e-01 0.181 0 0
Interleukin-1 family signaling R-HSA-446652 6.597485e-01 0.181 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 6.607845e-01 0.180 0 0
IFNG signaling activates MAPKs R-HSA-9732724 6.611243e-01 0.180 0 0
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose R-HSA-9031528 6.611243e-01 0.180 0 0
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake R-HSA-9031525 6.611243e-01 0.180 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 6.611243e-01 0.180 0 0
Recycling of eIF2:GDP R-HSA-72731 6.611243e-01 0.180 0 0
RUNX1 regulates estrogen receptor mediated transcription R-HSA-8931987 6.611243e-01 0.180 0 0
NOSTRIN mediated eNOS trafficking R-HSA-203641 6.611243e-01 0.180 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 6.611243e-01 0.180 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 6.611243e-01 0.180 0 0
Mitochondrial ABC transporters R-HSA-1369007 6.611243e-01 0.180 0 0
VLDL clearance R-HSA-8964046 6.611243e-01 0.180 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 6.611243e-01 0.180 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 6.611243e-01 0.180 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 6.611243e-01 0.180 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 6.611243e-01 0.180 0 0
G1 Phase R-HSA-69236 6.620633e-01 0.179 0 0
Cyclin D associated events in G1 R-HSA-69231 6.620633e-01 0.179 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 6.627739e-01 0.179 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.627739e-01 0.179 0 0
Translesion synthesis by POLK R-HSA-5655862 6.627739e-01 0.179 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 6.627739e-01 0.179 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 6.627739e-01 0.179 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.627739e-01 0.179 0 0
Fibronectin matrix formation R-HSA-1566977 6.627739e-01 0.179 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.627739e-01 0.179 0 0
Platelet degranulation R-HSA-114608 6.714203e-01 0.173 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 6.722869e-01 0.172 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 6.737188e-01 0.172 0 0
Protein ubiquitination R-HSA-8852135 6.742189e-01 0.171 0 0
Fanconi Anemia Pathway R-HSA-6783310 6.781020e-01 0.169 0 0
Signaling by NOTCH R-HSA-157118 6.829330e-01 0.166 0 0
GPVI-mediated activation cascade R-HSA-114604 6.829988e-01 0.166 0 0
Calmodulin induced events R-HSA-111933 6.829988e-01 0.166 1 1
CaM pathway R-HSA-111997 6.829988e-01 0.166 1 0
SARS-CoV Infections R-HSA-9679506 6.830940e-01 0.166 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 6.865521e-01 0.163 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 6.866390e-01 0.163 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 6.873712e-01 0.163 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 6.873712e-01 0.163 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.873712e-01 0.163 0 0
Regulation of NPAS4 gene expression R-HSA-9768759 6.873712e-01 0.163 0 0
Uptake and function of anthrax toxins R-HSA-5210891 6.873712e-01 0.163 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.908317e-01 0.161 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.921758e-01 0.160 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.921758e-01 0.160 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.958916e-01 0.157 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 6.958916e-01 0.157 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.958916e-01 0.157 0 0
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 6.958916e-01 0.157 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.958916e-01 0.157 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.958916e-01 0.157 0 0
Activation of RAS in B cells R-HSA-1169092 6.958916e-01 0.157 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.958916e-01 0.157 0 0
Adrenoceptors R-HSA-390696 6.958916e-01 0.157 0 0
Activated NTRK2 signals through FYN R-HSA-9032500 6.958916e-01 0.157 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 6.958916e-01 0.157 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 6.991118e-01 0.155 0 0
Degradation of DVL R-HSA-4641258 7.000058e-01 0.155 0 0
Organelle biogenesis and maintenance R-HSA-1852241 7.012123e-01 0.154 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 7.054652e-01 0.152 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.084349e-01 0.150 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.084349e-01 0.150 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 7.086250e-01 0.150 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 7.086250e-01 0.150 0 0
G beta:gamma signalling through PLC beta R-HSA-418217 7.104731e-01 0.148 0 0
Polo-like kinase mediated events R-HSA-156711 7.104731e-01 0.148 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 7.104731e-01 0.148 0 0
Presynaptic function of Kainate receptors R-HSA-500657 7.104731e-01 0.148 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 7.104731e-01 0.148 0 0
Nephron development R-HSA-9831926 7.104731e-01 0.148 0 0
Integrin cell surface interactions R-HSA-216083 7.110890e-01 0.148 0 0
Telomere Extension By Telomerase R-HSA-171319 7.111404e-01 0.148 0 0
Platelet activation, signaling and aggregation R-HSA-76002 7.165039e-01 0.145 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 7.193506e-01 0.143 0 0
Gastrulation R-HSA-9758941 7.197336e-01 0.143 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 7.227487e-01 0.141 0 0
Intraflagellar transport R-HSA-5620924 7.231027e-01 0.141 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 7.270938e-01 0.138 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 7.270938e-01 0.138 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 7.270938e-01 0.138 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 7.270938e-01 0.138 0 0
p75NTR regulates axonogenesis R-HSA-193697 7.270938e-01 0.138 0 0
mRNA Editing R-HSA-75072 7.270938e-01 0.138 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 7.270938e-01 0.138 0 0
Regulation of signaling by NODAL R-HSA-1433617 7.270938e-01 0.138 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 7.270938e-01 0.138 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 7.270938e-01 0.138 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 7.270938e-01 0.138 0 0
Regulated proteolysis of p75NTR R-HSA-193692 7.270938e-01 0.138 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 7.270938e-01 0.138 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 7.278200e-01 0.138 0 0
Influenza Infection R-HSA-168255 7.301822e-01 0.137 0 0
Plasma lipoprotein clearance R-HSA-8964043 7.320200e-01 0.135 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 7.321275e-01 0.135 0 0
Translesion Synthesis by POLH R-HSA-110320 7.321275e-01 0.135 0 0
E2F mediated regulation of DNA replication R-HSA-113510 7.321275e-01 0.135 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 7.321275e-01 0.135 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 7.321275e-01 0.135 0 0
Specification of the neural plate border R-HSA-9834899 7.321275e-01 0.135 0 0
The NLRP3 inflammasome R-HSA-844456 7.321275e-01 0.135 0 0
STING mediated induction of host immune responses R-HSA-1834941 7.321275e-01 0.135 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 7.340888e-01 0.134 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 7.361889e-01 0.133 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 7.362897e-01 0.133 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 7.371614e-01 0.132 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 7.397864e-01 0.131 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 7.397864e-01 0.131 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 7.397864e-01 0.131 0 0
Signaling by Interleukins R-HSA-449147 7.410639e-01 0.130 0 0
Downstream TCR signaling R-HSA-202424 7.420149e-01 0.130 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 7.430226e-01 0.129 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 7.430226e-01 0.129 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 7.430226e-01 0.129 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 7.430226e-01 0.129 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 7.430226e-01 0.129 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 7.470347e-01 0.127 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 7.470347e-01 0.127 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 7.470347e-01 0.127 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 7.470347e-01 0.127 0 0
Interleukin-2 family signaling R-HSA-451927 7.470347e-01 0.127 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 7.493614e-01 0.125 0 0
DNA Replication R-HSA-69306 7.522106e-01 0.124 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 7.523882e-01 0.124 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 7.523882e-01 0.124 0 0
Signaling by NODAL R-HSA-1181150 7.523882e-01 0.124 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 7.523882e-01 0.124 0 0
Eicosanoid ligand-binding receptors R-HSA-391903 7.523882e-01 0.124 0 0
Binding and entry of HIV virion R-HSA-173107 7.550962e-01 0.122 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 7.550962e-01 0.122 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 7.550962e-01 0.122 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.550962e-01 0.122 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 7.626156e-01 0.118 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 7.626156e-01 0.118 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 7.634062e-01 0.117 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 7.669958e-01 0.115 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 7.713131e-01 0.113 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 7.713131e-01 0.113 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 7.713131e-01 0.113 0 0
Signaling by Insulin receptor R-HSA-74752 7.718869e-01 0.112 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 7.723919e-01 0.112 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 7.723919e-01 0.112 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 7.751175e-01 0.111 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 7.751175e-01 0.111 0 0
Intra-Golgi traffic R-HSA-6811438 7.751175e-01 0.111 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 7.758098e-01 0.110 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 7.783420e-01 0.109 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 7.783420e-01 0.109 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.802268e-01 0.108 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 7.802268e-01 0.108 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.802268e-01 0.108 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.802268e-01 0.108 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 7.802268e-01 0.108 0 0
SARS-CoV-2 modulates autophagy R-HSA-9754560 7.802268e-01 0.108 0 0
Transport of RCbl within the body R-HSA-9758890 7.802268e-01 0.108 0 0
Prostanoid ligand receptors R-HSA-391908 7.802268e-01 0.108 0 0
Signaling by NOTCH4 R-HSA-9013694 7.818773e-01 0.107 0 0
HCMV Late Events R-HSA-9610379 7.821195e-01 0.107 0 0
Ca-dependent events R-HSA-111996 7.882075e-01 0.103 1 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.889630e-01 0.103 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 7.889630e-01 0.103 0 0
Assembly Of The HIV Virion R-HSA-175474 7.889630e-01 0.103 0 0
Serine metabolism R-HSA-977347 7.889630e-01 0.103 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 7.891920e-01 0.103 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 7.892667e-01 0.103 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 7.903779e-01 0.102 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 7.926102e-01 0.101 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 7.965638e-01 0.099 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 7.965638e-01 0.099 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 7.997753e-01 0.097 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 8.017435e-01 0.096 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 8.027800e-01 0.095 0 0
DS-GAG biosynthesis R-HSA-2022923 8.027800e-01 0.095 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 8.027800e-01 0.095 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 8.027800e-01 0.095 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 8.027800e-01 0.095 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 8.027800e-01 0.095 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 8.027800e-01 0.095 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 8.027800e-01 0.095 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 8.027800e-01 0.095 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 8.041949e-01 0.095 0 0
Co-inhibition by PD-1 R-HSA-389948 8.049410e-01 0.094 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 8.054002e-01 0.094 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 8.054002e-01 0.094 0 0
Notch-HLH transcription pathway R-HSA-350054 8.054002e-01 0.094 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 8.054002e-01 0.094 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 8.054002e-01 0.094 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.063833e-01 0.093 0 0
Miscellaneous transport and binding events R-HSA-5223345 8.063833e-01 0.093 0 0
Toll-like Receptor Cascades R-HSA-168898 8.117975e-01 0.091 0 0
Surfactant metabolism R-HSA-5683826 8.125525e-01 0.090 0 0
RMTs methylate histone arginines R-HSA-3214858 8.125525e-01 0.090 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 8.193771e-01 0.087 0 0
Hyaluronan metabolism R-HSA-2142845 8.193771e-01 0.087 0 0
RNA Polymerase I Transcription R-HSA-73864 8.201978e-01 0.086 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 8.206877e-01 0.086 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 8.206877e-01 0.086 0 0
Synthesis of pyrophosphates in the cytosol R-HSA-1855167 8.206877e-01 0.086 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 8.206877e-01 0.086 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 8.206877e-01 0.086 0 0
Carnitine shuttle R-HSA-200425 8.206877e-01 0.086 0 0
Growth hormone receptor signaling R-HSA-982772 8.206877e-01 0.086 0 0
Maple Syrup Urine Disease R-HSA-9865114 8.230199e-01 0.085 0 0
Scavenging by Class F Receptors R-HSA-3000484 8.230199e-01 0.085 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 8.230199e-01 0.085 0 0
Interleukin-15 signaling R-HSA-8983432 8.230199e-01 0.085 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 8.230199e-01 0.085 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 8.230199e-01 0.085 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 8.238386e-01 0.084 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.316205e-01 0.080 0 0
Regulation of Apoptosis R-HSA-169911 8.316205e-01 0.080 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 8.339465e-01 0.079 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 8.345563e-01 0.079 0 0
Translocation of ZAP-70 to Immunological synapse R-HSA-202430 8.348883e-01 0.078 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 8.348883e-01 0.078 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 8.348883e-01 0.078 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 8.348883e-01 0.078 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.372832e-01 0.077 0 0
Base Excision Repair R-HSA-73884 8.378701e-01 0.077 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 8.410159e-01 0.075 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 8.411838e-01 0.075 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 8.411838e-01 0.075 0 0
Adenylate cyclase activating pathway R-HSA-170660 8.411838e-01 0.075 0 0
Processing of SMDT1 R-HSA-8949664 8.411838e-01 0.075 0 0
CD28 dependent Vav1 pathway R-HSA-389359 8.411838e-01 0.075 0 0
Maturation of nucleoprotein R-HSA-9683610 8.411838e-01 0.075 0 0
Interleukin-6 signaling R-HSA-1059683 8.411838e-01 0.075 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.431436e-01 0.074 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.431436e-01 0.074 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.463166e-01 0.072 0 0
Cellular response to chemical stress R-HSA-9711123 8.473519e-01 0.072 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 8.480639e-01 0.072 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 8.480639e-01 0.072 0 0
Hyaluronan degradation R-HSA-2160916 8.480639e-01 0.072 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 8.480639e-01 0.072 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 8.480951e-01 0.072 0 0
SARS-CoV-2 Infection R-HSA-9694516 8.485413e-01 0.071 0 0
Amino acid transport across the plasma membrane R-HSA-352230 8.490054e-01 0.071 0 0
Interleukin-1 signaling R-HSA-9020702 8.533313e-01 0.069 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 8.539765e-01 0.069 0 0
Degradation of AXIN R-HSA-4641257 8.539765e-01 0.069 0 0
Signaling by Hedgehog R-HSA-5358351 8.541132e-01 0.068 1 0
Metal ion SLC transporters R-HSA-425410 8.543587e-01 0.068 0 0
BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV R-HSA-9859138 8.574844e-01 0.067 0 0
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 8.574844e-01 0.067 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 8.574844e-01 0.067 0 0
Synthesis of IPs in the nucleus R-HSA-1855191 8.574844e-01 0.067 0 0
TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 8.574844e-01 0.067 0 0
cGMP effects R-HSA-418457 8.574844e-01 0.067 0 0
Formation of the active cofactor, UDP-glucuronate R-HSA-173599 8.574844e-01 0.067 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 8.602755e-01 0.065 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 8.602755e-01 0.065 0 0
Sphingolipid catabolism R-HSA-9845614 8.602755e-01 0.065 0 0
Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855183 8.602755e-01 0.065 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 8.602755e-01 0.065 0 0
TRP channels R-HSA-3295583 8.602755e-01 0.065 0 0
Elastic fibre formation R-HSA-1566948 8.641497e-01 0.063 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.658659e-01 0.063 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 8.665817e-01 0.062 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 8.669703e-01 0.062 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 8.675573e-01 0.062 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 8.715819e-01 0.060 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 8.721128e-01 0.059 0 0
G beta:gamma signalling through BTK R-HSA-8964315 8.721128e-01 0.059 0 0
Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 8.721128e-01 0.059 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.721128e-01 0.059 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.721128e-01 0.059 0 0
Transport and metabolism of PAPS R-HSA-174362 8.721128e-01 0.059 0 0
Other semaphorin interactions R-HSA-416700 8.721128e-01 0.059 0 0
DNA Damage Reversal R-HSA-73942 8.721128e-01 0.059 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 8.736938e-01 0.059 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 8.736938e-01 0.059 0 0
Meiotic recombination R-HSA-912446 8.802621e-01 0.055 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 8.820403e-01 0.055 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.820403e-01 0.055 0 0
Inflammasomes R-HSA-622312 8.820403e-01 0.055 0 0
Attenuation phase R-HSA-3371568 8.826389e-01 0.054 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.826389e-01 0.054 0 0
Diseases of Immune System R-HSA-5260271 8.826389e-01 0.054 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.826389e-01 0.054 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 8.826389e-01 0.054 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 8.836468e-01 0.054 0 0
Defective GALNT12 causes CRCS1 R-HSA-5083636 8.852405e-01 0.053 0 0
Defective GALNT3 causes HFTC R-HSA-5083625 8.852405e-01 0.053 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 8.852405e-01 0.053 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 8.852405e-01 0.053 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 8.852405e-01 0.053 0 0
Disorders of transmembrane transporters R-HSA-5619115 8.876357e-01 0.052 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 8.879600e-01 0.052 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 8.894534e-01 0.051 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 8.894534e-01 0.051 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 8.894534e-01 0.051 0 0
Interleukin-12 signaling R-HSA-9020591 8.901150e-01 0.051 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.910148e-01 0.050 0 0
Cap-dependent Translation Initiation R-HSA-72737 8.945078e-01 0.048 0 0
Eukaryotic Translation Initiation R-HSA-72613 8.945078e-01 0.048 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.952218e-01 0.048 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.970213e-01 0.047 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 8.970213e-01 0.047 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.970213e-01 0.047 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.970213e-01 0.047 0 0
Phase 2 - plateau phase R-HSA-5576893 8.970213e-01 0.047 0 0
Heme assimilation R-HSA-9927020 8.970213e-01 0.047 0 0
tRNA modification in the mitochondrion R-HSA-6787450 8.970213e-01 0.047 0 0
Synthesis of PG R-HSA-1483148 8.970213e-01 0.047 0 0
Coenzyme A biosynthesis R-HSA-196783 8.970213e-01 0.047 0 0
Parasitic Infection Pathways R-HSA-9824443 8.976798e-01 0.047 0 0
Leishmania infection R-HSA-9658195 8.976798e-01 0.047 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.988508e-01 0.046 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 8.988508e-01 0.046 0 0
HIV Transcription Initiation R-HSA-167161 8.988508e-01 0.046 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.988508e-01 0.046 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 8.988508e-01 0.046 0 0
Degradation of CRY and PER proteins R-HSA-9932298 8.988508e-01 0.046 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.988508e-01 0.046 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.993921e-01 0.046 0 0
Mitochondrial biogenesis R-HSA-1592230 8.994080e-01 0.046 0 0
Hemostasis R-HSA-109582 9.005995e-01 0.045 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 9.006305e-01 0.045 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 9.006305e-01 0.045 0 0
Post-translational protein phosphorylation R-HSA-8957275 9.017553e-01 0.045 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 9.020665e-01 0.045 0 0
PCP/CE pathway R-HSA-4086400 9.021369e-01 0.045 0 0
Ion channel transport R-HSA-983712 9.032101e-01 0.044 0 0
Neutrophil degranulation R-HSA-6798695 9.061975e-01 0.043 0 0
SLC-mediated transport of amino acids R-HSA-9958863 9.071967e-01 0.042 0 0
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 9.075934e-01 0.042 0 0
Defective C1GALT1C1 causes TNPS R-HSA-5083632 9.075934e-01 0.042 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 9.075934e-01 0.042 0 0
Glycogen storage diseases R-HSA-3229121 9.075934e-01 0.042 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 9.075934e-01 0.042 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 9.088650e-01 0.042 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 9.088650e-01 0.042 0 0
Molecules associated with elastic fibres R-HSA-2129379 9.088650e-01 0.042 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 9.125606e-01 0.040 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 9.130160e-01 0.040 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 9.130160e-01 0.040 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 9.142522e-01 0.039 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 9.161362e-01 0.038 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 9.164567e-01 0.038 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 9.164567e-01 0.038 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 9.170806e-01 0.038 0 0
PKA activation in glucagon signalling R-HSA-164378 9.170806e-01 0.038 0 0
PKA activation R-HSA-163615 9.170806e-01 0.038 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9679504 9.170806e-01 0.038 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.171506e-01 0.038 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.180415e-01 0.037 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.185377e-01 0.037 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.228173e-01 0.035 0 0
Regulation of necroptotic cell death R-HSA-5675482 9.234509e-01 0.035 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 9.253531e-01 0.034 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.253531e-01 0.034 0 0
Somitogenesis R-HSA-9824272 9.253531e-01 0.034 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.253531e-01 0.034 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.253531e-01 0.034 0 0
Pyrimidine biosynthesis R-HSA-500753 9.255943e-01 0.034 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 9.255943e-01 0.034 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.255943e-01 0.034 0 0
Other interleukin signaling R-HSA-449836 9.255943e-01 0.034 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 9.255943e-01 0.034 0 0
Maturation of nucleoprotein R-HSA-9694631 9.255943e-01 0.034 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 9.255943e-01 0.034 0 0
Transmission across Chemical Synapses R-HSA-112315 9.278845e-01 0.033 0 0
Hedgehog 'on' state R-HSA-5632684 9.281336e-01 0.032 1 0
Formation of the cornified envelope R-HSA-6809371 9.286486e-01 0.032 0 0
SARS-CoV-1 Infection R-HSA-9678108 9.292432e-01 0.032 0 0
Effects of PIP2 hydrolysis R-HSA-114508 9.298901e-01 0.032 0 0
Vpu mediated degradation of CD4 R-HSA-180534 9.298901e-01 0.032 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 9.309004e-01 0.031 0 0
PPARA activates gene expression R-HSA-1989781 9.326967e-01 0.030 0 0
Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 9.332343e-01 0.030 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 9.332343e-01 0.030 0 0
Glycogen synthesis R-HSA-3322077 9.332343e-01 0.030 0 0
Pregnenolone biosynthesis R-HSA-196108 9.332343e-01 0.030 0 0
Protein hydroxylation R-HSA-9629569 9.332343e-01 0.030 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 9.358146e-01 0.029 0 0
Signaling by NOTCH2 R-HSA-1980145 9.358146e-01 0.029 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 9.358146e-01 0.029 0 0
Formation of paraxial mesoderm R-HSA-9793380 9.398322e-01 0.027 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 9.400903e-01 0.027 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 9.400903e-01 0.027 0 0
ERK/MAPK targets R-HSA-198753 9.400903e-01 0.027 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 9.400903e-01 0.027 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 9.400903e-01 0.027 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 9.400903e-01 0.027 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 9.412621e-01 0.026 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 9.433160e-01 0.025 0 0
Interferon gamma signaling R-HSA-877300 9.441208e-01 0.025 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.456166e-01 0.024 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.460796e-01 0.024 0 0
CS-GAG biosynthesis R-HSA-2022870 9.462426e-01 0.024 0 0
Molybdenum cofactor biosynthesis R-HSA-947581 9.462426e-01 0.024 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.462426e-01 0.024 0 0
G1/S-Specific Transcription R-HSA-69205 9.462681e-01 0.024 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 9.462681e-01 0.024 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 9.462681e-01 0.024 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 9.462681e-01 0.024 0 0
Interleukin-12 family signaling R-HSA-447115 9.466520e-01 0.024 0 0
G alpha (s) signalling events R-HSA-418555 9.484957e-01 0.023 1 1
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.508657e-01 0.022 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.517634e-01 0.021 0 0
Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676 9.517634e-01 0.021 0 0
Hedgehog ligand biogenesis R-HSA-5358346 9.533544e-01 0.021 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 9.550862e-01 0.020 0 0
Cardiac conduction R-HSA-5576891 9.552738e-01 0.020 0 0
Termination of O-glycan biosynthesis R-HSA-977068 9.567175e-01 0.019 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.567175e-01 0.019 0 0
Phospholipid metabolism R-HSA-1483257 9.567408e-01 0.019 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 9.569356e-01 0.019 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 9.569356e-01 0.019 0 0
RAS processing R-HSA-9648002 9.589583e-01 0.018 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 9.589583e-01 0.018 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 9.589583e-01 0.018 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 9.595668e-01 0.018 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.611631e-01 0.017 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.611631e-01 0.017 0 0
TNFs bind their physiological receptors R-HSA-5669034 9.611631e-01 0.017 0 0
Interleukin-6 family signaling R-HSA-6783589 9.611631e-01 0.017 0 0
Glycogen metabolism R-HSA-8982491 9.625091e-01 0.017 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.625091e-01 0.017 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 9.640528e-01 0.016 0 0
Beta-oxidation of pristanoyl-CoA R-HSA-389887 9.651523e-01 0.015 0 0
Acyl chain remodelling of PS R-HSA-1482801 9.651523e-01 0.015 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.651523e-01 0.015 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 9.657638e-01 0.015 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.657638e-01 0.015 0 0
Maturation of spike protein R-HSA-9694548 9.657638e-01 0.015 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 9.657638e-01 0.015 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 9.657638e-01 0.015 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 9.687320e-01 0.014 0 0
Suppression of phagosomal maturation R-HSA-9637687 9.687320e-01 0.014 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 9.701584e-01 0.013 0 0
ECM proteoglycans R-HSA-3000178 9.711117e-01 0.013 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 9.714765e-01 0.013 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 9.714765e-01 0.013 0 0
Depyrimidination R-HSA-73928 9.714765e-01 0.013 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 9.714765e-01 0.013 0 0
Packaging Of Telomere Ends R-HSA-171306 9.719441e-01 0.012 0 0
Cristae formation R-HSA-8949613 9.719441e-01 0.012 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 9.719441e-01 0.012 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 9.719441e-01 0.012 0 0
Insulin processing R-HSA-264876 9.719441e-01 0.012 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.719441e-01 0.012 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.732127e-01 0.012 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.742277e-01 0.011 0 0
Insulin receptor recycling R-HSA-77387 9.748264e-01 0.011 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 9.748264e-01 0.011 0 0
Iron assimilation using enterobactin R-HSA-9638334 9.748264e-01 0.011 0 0
Pyrimidine salvage R-HSA-73614 9.748264e-01 0.011 0 0
Pyroptosis R-HSA-5620971 9.748264e-01 0.011 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.756426e-01 0.011 0 0
Proteasome assembly R-HSA-9907900 9.762637e-01 0.010 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.762637e-01 0.010 0 0
Amine ligand-binding receptors R-HSA-375280 9.762637e-01 0.010 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.762637e-01 0.010 0 0
rRNA processing R-HSA-72312 9.762663e-01 0.010 0 0
Neddylation R-HSA-8951664 9.767056e-01 0.010 0 0
Regulation of insulin secretion R-HSA-422356 9.771644e-01 0.010 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 9.774128e-01 0.010 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.774128e-01 0.010 0 0
RAB geranylgeranylation R-HSA-8873719 9.775787e-01 0.010 0 0
tRNA Aminoacylation R-HSA-379724 9.775787e-01 0.010 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.783559e-01 0.010 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 9.783559e-01 0.010 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.783559e-01 0.010 0 0
Diseases of programmed cell death R-HSA-9645723 9.790865e-01 0.009 0 0
Neurotransmitter clearance R-HSA-112311 9.797336e-01 0.009 0 0
ABC-family proteins mediated transport R-HSA-382556 9.800641e-01 0.009 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 9.802690e-01 0.009 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 9.802690e-01 0.009 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.806094e-01 0.009 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.812074e-01 0.008 0 0
Immune System R-HSA-168256 9.816664e-01 0.008 0 0
Synthesis of PC R-HSA-1483191 9.820176e-01 0.008 0 0
ABC transporter disorders R-HSA-5619084 9.830949e-01 0.007 0 0
Interleukin-10 signaling R-HSA-6783783 9.830949e-01 0.007 0 0
Gluconeogenesis R-HSA-70263 9.836153e-01 0.007 0 0
DAG1 glycosylations R-HSA-8931838 9.836846e-01 0.007 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 9.836846e-01 0.007 0 0
Integration of energy metabolism R-HSA-163685 9.841472e-01 0.007 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.847789e-01 0.007 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 9.850747e-01 0.007 0 0
Chemokine receptors bind chemokines R-HSA-380108 9.850747e-01 0.007 0 0
Cellular response to hypoxia R-HSA-1234174 9.852517e-01 0.006 0 0
Eukaryotic Translation Elongation R-HSA-156842 9.854617e-01 0.006 0 0
RSV-host interactions R-HSA-9833110 9.858816e-01 0.006 0 0
Azathioprine ADME R-HSA-9748787 9.864072e-01 0.006 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.864492e-01 0.006 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 9.868657e-01 0.006 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 9.868657e-01 0.006 0 0
CS/DS degradation R-HSA-2024101 9.868657e-01 0.006 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.868657e-01 0.006 0 0
Heme degradation R-HSA-189483 9.868657e-01 0.006 0 0
Neuronal System R-HSA-112316 9.875450e-01 0.005 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.876236e-01 0.005 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.876236e-01 0.005 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.879062e-01 0.005 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.882156e-01 0.005 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 9.882156e-01 0.005 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 9.882156e-01 0.005 0 0
Calnexin/calreticulin cycle R-HSA-901042 9.882156e-01 0.005 0 0
Signal amplification R-HSA-392518 9.882156e-01 0.005 0 0
Regulated Necrosis R-HSA-5218859 9.885700e-01 0.005 0 0
Stimuli-sensing channels R-HSA-2672351 9.893450e-01 0.005 0 0
PERK regulates gene expression R-HSA-381042 9.894268e-01 0.005 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.899708e-01 0.004 0 0
PRC2 methylates histones and DNA R-HSA-212300 9.905137e-01 0.004 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.906700e-01 0.004 0 0
Viral Infection Pathways R-HSA-9824446 9.909131e-01 0.004 0 0
Voltage gated Potassium channels R-HSA-1296072 9.914888e-01 0.004 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 9.914888e-01 0.004 0 0
Cleavage of the damaged purine R-HSA-110331 9.914888e-01 0.004 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 9.914888e-01 0.004 0 0
NCAM1 interactions R-HSA-419037 9.914888e-01 0.004 0 0
SLC-mediated transport of organic cations R-HSA-549127 9.914888e-01 0.004 0 0
Metabolism of folate and pterines R-HSA-196757 9.914888e-01 0.004 0 0
G alpha (z) signalling events R-HSA-418597 9.915122e-01 0.004 0 0
Paracetamol ADME R-HSA-9753281 9.915122e-01 0.004 0 0
Post-translational protein modification R-HSA-597592 9.922854e-01 0.003 0 0
tRNA processing in the mitochondrion R-HSA-6785470 9.923638e-01 0.003 0 0
Depurination R-HSA-73927 9.923638e-01 0.003 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 9.923638e-01 0.003 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.923638e-01 0.003 0 0
Dectin-2 family R-HSA-5621480 9.929794e-01 0.003 0 0
ER-Phagosome pathway R-HSA-1236974 9.934865e-01 0.003 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.938532e-01 0.003 0 0
Tryptophan catabolism R-HSA-71240 9.938532e-01 0.003 0 0
Neurotransmitter release cycle R-HSA-112310 9.939948e-01 0.003 0 0
Peroxisomal protein import R-HSA-9033241 9.941974e-01 0.003 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.944347e-01 0.002 0 0
Interferon alpha/beta signaling R-HSA-909733 9.944347e-01 0.002 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 9.945428e-01 0.002 0 0
Metabolism of polyamines R-HSA-351202 9.947262e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9694635 9.947540e-01 0.002 0 0
Translation of Structural Proteins R-HSA-9683701 9.950523e-01 0.002 0 0
Cholesterol biosynthesis R-HSA-191273 9.951945e-01 0.002 0 0
Aquaporin-mediated transport R-HSA-445717 9.952075e-01 0.002 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.953008e-01 0.002 0 0
Activation of GABAB receptors R-HSA-991365 9.955611e-01 0.002 0 0
GABA B receptor activation R-HSA-977444 9.955611e-01 0.002 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 9.955611e-01 0.002 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.955991e-01 0.002 0 0
FCGR activation R-HSA-2029481 9.956718e-01 0.002 0 0
Response of Mtb to phagocytosis R-HSA-9637690 9.960176e-01 0.002 0 0
Antigen processing-Cross presentation R-HSA-1236975 9.963001e-01 0.002 0 0
Cellular response to starvation R-HSA-9711097 9.963564e-01 0.002 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.964074e-01 0.002 0 0
Methylation R-HSA-156581 9.964271e-01 0.002 0 0
Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 9.964271e-01 0.002 0 0
Asparagine N-linked glycosylation R-HSA-446203 9.965999e-01 0.001 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.966227e-01 0.001 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 9.967946e-01 0.001 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.969108e-01 0.001 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.971243e-01 0.001 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.973003e-01 0.001 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.973003e-01 0.001 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.974201e-01 0.001 0 0
Metal ion assimilation from the host R-HSA-9638482 9.981758e-01 0.001 0 0
Peptide chain elongation R-HSA-156902 9.981940e-01 0.001 0 0
Complex IV assembly R-HSA-9864848 9.983289e-01 0.001 0 0
The phototransduction cascade R-HSA-2514856 9.983289e-01 0.001 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 9.986226e-01 0.001 0 0
Nucleotide biosynthesis R-HSA-8956320 9.986551e-01 0.001 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 9.987419e-01 0.001 0 0
G alpha (q) signalling events R-HSA-416476 9.987710e-01 0.001 1 1
Platelet homeostasis R-HSA-418346 9.987718e-01 0.001 0 0
Glucuronidation R-HSA-156588 9.987935e-01 0.001 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 9.988511e-01 0.000 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.989176e-01 0.000 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.990290e-01 0.000 0 0
Collagen formation R-HSA-1474290 9.990424e-01 0.000 0 0
Extracellular matrix organization R-HSA-1474244 9.990618e-01 0.000 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.990799e-01 0.000 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 9.991259e-01 0.000 0 0
Scavenging of heme from plasma R-HSA-2168880 9.992023e-01 0.000 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.992186e-01 0.000 0 0
Ribosome-associated quality control R-HSA-9948299 9.992341e-01 0.000 0 0
Amyloid fiber formation R-HSA-977225 9.993150e-01 0.000 0 0
GABA receptor activation R-HSA-977443 9.993712e-01 0.000 0 0
Nucleotide salvage R-HSA-8956321 9.994359e-01 0.000 0 0
Mitochondrial protein import R-HSA-1268020 9.994940e-01 0.000 0 0
Peptide ligand-binding receptors R-HSA-375276 9.995165e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.995466e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.995636e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.995636e-01 0.000 0 0
Classical antibody-mediated complement activation R-HSA-173623 9.996896e-01 0.000 0 0
Keratinization R-HSA-6805567 9.997039e-01 0.000 0 0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 9.997061e-01 0.000 0 0
Nicotinate metabolism R-HSA-196807 9.997061e-01 0.000 0 0
Metabolism of steroid hormones R-HSA-196071 9.997061e-01 0.000 0 0
O-linked glycosylation of mucins R-HSA-913709 9.997364e-01 0.000 0 0
Innate Immune System R-HSA-168249 9.997399e-01 0.000 0 0
Glycosphingolipid catabolism R-HSA-9840310 9.997879e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.998097e-01 0.000 0 0
Retinoid metabolism and transport R-HSA-975634 9.998097e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.998097e-01 0.000 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 9.998469e-01 0.000 0 0
Aspirin ADME R-HSA-9749641 9.998469e-01 0.000 0 0
Eukaryotic Translation Termination R-HSA-72764 9.998736e-01 0.000 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 9.998736e-01 0.000 0 0
Iron uptake and transport R-HSA-917937 9.998768e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.999153e-01 0.000 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.999203e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999225e-01 0.000 0 0
Selenocysteine synthesis R-HSA-2408557 9.999308e-01 0.000 0 0
Metabolism of fat-soluble vitamins R-HSA-6806667 9.999359e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999372e-01 0.000 1 0
Viral mRNA Translation R-HSA-192823 9.999434e-01 0.000 0 0
Protein localization R-HSA-9609507 9.999467e-01 0.000 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.999537e-01 0.000 0 0
Creation of C4 and C2 activators R-HSA-166786 9.999622e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999638e-01 0.000 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.999658e-01 0.000 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.999666e-01 0.000 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.999748e-01 0.000 0 0
Antimicrobial peptides R-HSA-6803157 9.999772e-01 0.000 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.999784e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999826e-01 0.000 0 0
Initial triggering of complement R-HSA-166663 9.999848e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999858e-01 0.000 0 0
Infectious disease R-HSA-5663205 9.999864e-01 0.000 0 0
Mitochondrial protein degradation R-HSA-9837999 9.999875e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.999910e-01 0.000 0 0
Potassium Channels R-HSA-1296071 9.999910e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.999927e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999952e-01 0.000 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.999958e-01 0.000 0 0
Selenoamino acid metabolism R-HSA-2408522 9.999961e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.999962e-01 0.000 1 0
Complement cascade R-HSA-166658 9.999964e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.999972e-01 0.000 0 0
Translation R-HSA-72766 9.999978e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.999980e-01 0.000 1 0
Mitochondrial translation termination R-HSA-5419276 9.999980e-01 0.000 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.999982e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999986e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.999988e-01 0.000 0 0
O-linked glycosylation R-HSA-5173105 9.999990e-01 0.000 0 0
Disease R-HSA-1643685 9.999993e-01 0.000 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.999996e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999996e-01 0.000 0 0
Glycosphingolipid metabolism R-HSA-1660662 9.999997e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999997e-01 0.000 0 0
Arachidonate metabolism R-HSA-2142753 9.999998e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999999e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999999e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999999e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 1.000000e+00 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 1.000000e+00 0.000 0 0
Metabolism of proteins R-HSA-392499 1.000000e+00 0.000 0 0
Drug ADME R-HSA-9748784 1.000000e+00 0.000 0 0
Transport of small molecules R-HSA-382551 1.000000e+00 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Respiratory electron transport R-HSA-611105 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 1.000000e+00 -0.000 0 0
Activation of SMO R-HSA-5635838 1.000000e+00 0.000 1 1
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Metabolism of RNA R-HSA-8953854 4.873879e-14 13.312 0 0
Cell Cycle R-HSA-1640170 6.140644e-13 12.212 0 0
M Phase R-HSA-68886 1.214031e-09 8.916 0 0
Cell Cycle, Mitotic R-HSA-69278 1.298214e-09 8.887 0 0
Separation of Sister Chromatids R-HSA-2467813 1.328086e-08 7.877 0 0
mRNA Splicing - Major Pathway R-HSA-72163 2.194706e-08 7.659 0 0
mRNA Splicing R-HSA-72172 3.714932e-08 7.430 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 4.414627e-08 7.355 0 0
Mitotic Prometaphase R-HSA-68877 4.984317e-08 7.302 0 0
Mitotic Anaphase R-HSA-68882 6.853958e-08 7.164 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 7.758163e-08 7.110 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.005918e-07 6.997 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 1.523004e-07 6.817 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 1.683155e-07 6.774 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 3.835753e-07 6.416 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 6.687057e-07 6.175 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 1.193437e-06 5.923 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 2.334707e-06 5.632 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.974202e-06 5.527 0 0
Cell Cycle Checkpoints R-HSA-69620 3.001070e-06 5.523 0 0
Apoptosis R-HSA-109581 3.306688e-06 5.481 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 4.583944e-06 5.339 0 0
Signaling by ALK in cancer R-HSA-9700206 4.583944e-06 5.339 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 5.420450e-06 5.266 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 7.862789e-06 5.104 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 8.480689e-06 5.072 0 0
Apoptotic execution phase R-HSA-75153 9.831288e-06 5.007 0 0
rRNA processing R-HSA-72312 1.092251e-05 4.962 0 0
Smooth Muscle Contraction R-HSA-445355 1.283681e-05 4.892 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 1.906980e-05 4.720 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 2.585165e-05 4.588 0 0
Protein ubiquitination R-HSA-8852135 2.446239e-05 4.612 0 0
Aggrephagy R-HSA-9646399 2.747012e-05 4.561 0 0
Cell-Cell communication R-HSA-1500931 2.722044e-05 4.565 0 0
MITF-M-dependent gene expression R-HSA-9856651 2.643745e-05 4.578 0 0
Chromatin modifying enzymes R-HSA-3247509 2.757329e-05 4.560 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 3.024692e-05 4.519 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 3.024692e-05 4.519 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.631493e-05 4.440 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.701756e-05 4.432 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 4.039079e-05 4.394 0 0
Recycling pathway of L1 R-HSA-437239 4.482667e-05 4.348 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 4.417469e-05 4.355 0 0
Chromatin organization R-HSA-4839726 5.028616e-05 4.299 0 0
L1CAM interactions R-HSA-373760 5.584147e-05 4.253 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 6.284947e-05 4.202 0 0
Cell junction organization R-HSA-446728 7.048490e-05 4.152 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 7.381537e-05 4.132 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 9.553537e-05 4.020 0 0
G2/M Checkpoints R-HSA-69481 9.752691e-05 4.011 0 0
DNA Repair R-HSA-73894 1.022202e-04 3.990 0 0
Programmed Cell Death R-HSA-5357801 1.547825e-04 3.810 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 1.806961e-04 3.743 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.806961e-04 3.743 0 0
Signaling by Hippo R-HSA-2028269 1.826079e-04 3.738 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.850876e-04 3.733 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.340025e-04 3.631 0 0
G2/M Transition R-HSA-69275 2.265474e-04 3.645 0 0
Adherens junctions interactions R-HSA-418990 2.311067e-04 3.636 0 0
Cellular response to heat stress R-HSA-3371556 2.420802e-04 3.616 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.460354e-04 3.609 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 2.747287e-04 3.561 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 2.747287e-04 3.561 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.698904e-04 3.569 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 2.715956e-04 3.566 0 0
Regulation of CDH1 Function R-HSA-9764561 2.910468e-04 3.536 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 2.833938e-04 3.548 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.403296e-04 3.468 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 3.369518e-04 3.472 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 3.519593e-04 3.454 0 0
Dual Incision in GG-NER R-HSA-5696400 3.643303e-04 3.439 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 3.579200e-04 3.446 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.646973e-04 3.438 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 3.646973e-04 3.438 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 3.786367e-04 3.422 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 4.027694e-04 3.395 0 0
Nervous system development R-HSA-9675108 3.877921e-04 3.411 0 0
Cellular responses to stimuli R-HSA-8953897 4.058240e-04 3.392 0 0
PKR-mediated signaling R-HSA-9833482 4.180615e-04 3.379 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 4.480172e-04 3.349 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.561977e-04 3.341 0 0
Post NMDA receptor activation events R-HSA-438064 4.657521e-04 3.332 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 4.947207e-04 3.306 0 0
DNA Double Strand Break Response R-HSA-5693606 4.826986e-04 3.316 0 0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence R-HSA-9825895 4.947207e-04 3.306 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.273788e-04 3.278 0 0
Translation initiation complex formation R-HSA-72649 5.279998e-04 3.277 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.285559e-04 3.277 0 0
Cellular responses to stress R-HSA-2262752 6.106097e-04 3.214 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 6.703226e-04 3.174 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 6.716859e-04 3.173 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 7.249957e-04 3.140 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 8.475297e-04 3.072 0 0
Epigenetic regulation of gene expression R-HSA-212165 8.553411e-04 3.068 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 8.754839e-04 3.058 0 0
Nucleotide Excision Repair R-HSA-5696398 9.452904e-04 3.024 0 0
Membrane Trafficking R-HSA-199991 8.961221e-04 3.048 1 0
Dual incision in TC-NER R-HSA-6782135 9.811756e-04 3.008 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 9.811756e-04 3.008 0 0
Deubiquitination R-HSA-5688426 1.007412e-03 2.997 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.014073e-03 2.994 0 0
Axon guidance R-HSA-422475 9.584140e-04 3.018 0 0
Muscle contraction R-HSA-397014 1.016708e-03 2.993 0 0
Striated Muscle Contraction R-HSA-390522 1.035100e-03 2.985 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.052876e-03 2.978 0 0
S Phase R-HSA-69242 1.084618e-03 2.965 0 0
Chaperone Mediated Autophagy R-HSA-9613829 1.158165e-03 2.936 0 0
Transport of connexons to the plasma membrane R-HSA-190872 1.158165e-03 2.936 0 0
Josephin domain DUBs R-HSA-5689877 1.163615e-03 2.934 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 1.163615e-03 2.934 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 1.294424e-03 2.888 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.256441e-03 2.901 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 1.309934e-03 2.883 0 0
Cell-cell junction organization R-HSA-421270 1.377004e-03 2.861 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.425404e-03 2.846 0 0
ISG15 antiviral mechanism R-HSA-1169408 1.425404e-03 2.846 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.475733e-03 2.831 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.599497e-03 2.796 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.599497e-03 2.796 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 1.515276e-03 2.820 0 0
Translesion Synthesis by POLH R-HSA-110320 1.509248e-03 2.821 0 0
Oncogene Induced Senescence R-HSA-2559585 1.515276e-03 2.820 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.651935e-03 2.782 0 0
COPI-mediated anterograde transport R-HSA-6807878 1.679951e-03 2.775 0 0
p75NTR signals via NF-kB R-HSA-193639 1.681288e-03 2.774 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.681288e-03 2.774 0 0
SARS-CoV-2-host interactions R-HSA-9705683 1.703239e-03 2.769 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.806764e-03 2.743 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.816182e-03 2.741 0 0
DNA Damage Bypass R-HSA-73893 2.006109e-03 2.698 0 0
Homology Directed Repair R-HSA-5693538 1.932907e-03 2.714 0 0
Gap junction trafficking and regulation R-HSA-157858 2.006109e-03 2.698 0 0
Semaphorin interactions R-HSA-373755 1.973239e-03 2.705 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 2.010134e-03 2.697 0 0
Amplification of signal from the kinetochores R-HSA-141424 2.162179e-03 2.665 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 2.162179e-03 2.665 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 2.283629e-03 2.641 0 0
Ub-specific processing proteases R-HSA-5689880 2.303284e-03 2.638 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 2.332329e-03 2.632 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.371809e-03 2.625 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.371809e-03 2.625 0 0
NF-kB is activated and signals survival R-HSA-209560 2.371809e-03 2.625 0 0
Mitotic Spindle Checkpoint R-HSA-69618 2.537723e-03 2.596 0 0
Hedgehog 'off' state R-HSA-5610787 2.537723e-03 2.596 0 0
Gap junction trafficking R-HSA-190828 2.666462e-03 2.574 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.666462e-03 2.574 0 0
HSF1-dependent transactivation R-HSA-3371571 2.684693e-03 2.571 0 0
Processing of DNA double-strand break ends R-HSA-5693607 2.893475e-03 2.539 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.914962e-03 2.535 0 0
Selective autophagy R-HSA-9663891 2.994785e-03 2.524 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 3.020692e-03 2.520 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 3.021969e-03 2.520 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 3.089020e-03 2.510 0 0
Gene expression (Transcription) R-HSA-74160 3.124928e-03 2.505 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 3.158594e-03 2.501 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 3.368038e-03 2.473 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 3.540317e-03 2.451 0 0
Meiotic synapsis R-HSA-1221632 3.540317e-03 2.451 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 3.540317e-03 2.451 0 0
VLDLR internalisation and degradation R-HSA-8866427 3.247391e-03 2.488 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.247391e-03 2.488 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 3.543289e-03 2.451 0 0
Signaling downstream of RAS mutants R-HSA-9649948 3.588606e-03 2.445 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 3.588606e-03 2.445 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 3.588606e-03 2.445 0 0
Signaling by RAS mutants R-HSA-6802949 3.588606e-03 2.445 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 3.654693e-03 2.437 0 0
mTORC1-mediated signalling R-HSA-166208 3.830529e-03 2.417 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.830529e-03 2.417 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 4.108437e-03 2.386 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 4.756840e-03 2.323 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 4.704575e-03 2.327 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.545227e-03 2.342 0 0
Oncogenic MAPK signaling R-HSA-6802957 4.444334e-03 2.352 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 4.343630e-03 2.362 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 4.649207e-03 2.333 0 0
Cytokine Signaling in Immune system R-HSA-1280215 4.850087e-03 2.314 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 4.954782e-03 2.305 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 4.954782e-03 2.305 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.261446e-03 2.279 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 5.691172e-03 2.245 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.691172e-03 2.245 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.723926e-03 2.242 0 0
RUNX1 regulates expression of components of tight junctions R-HSA-8935964 5.821962e-03 2.235 0 0
Maturation of protein E R-HSA-9694493 5.821962e-03 2.235 0 0
Maturation of protein E R-HSA-9683683 5.821962e-03 2.235 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 5.865174e-03 2.232 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 6.240867e-03 2.205 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 6.317746e-03 2.199 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 6.317746e-03 2.199 0 0
Pexophagy R-HSA-9664873 6.317746e-03 2.199 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.320815e-03 2.135 0 0
AURKA Activation by TPX2 R-HSA-8854518 6.989517e-03 2.156 0 0
Regulation of endogenous retroelements R-HSA-9842860 6.511947e-03 2.186 0 0
Translesion synthesis by REV1 R-HSA-110312 7.320815e-03 2.135 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.182929e-03 2.144 0 0
Signaling by NOTCH4 R-HSA-9013694 7.182929e-03 2.144 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 6.464755e-03 2.189 0 0
Death Receptor Signaling R-HSA-73887 6.493268e-03 2.188 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 7.320815e-03 2.135 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 7.320815e-03 2.135 0 0
Signaling by Interleukins R-HSA-449147 7.348810e-03 2.134 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 7.354412e-03 2.133 0 0
Interferon Signaling R-HSA-913531 7.648519e-03 2.116 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 7.896594e-03 2.103 0 0
Macroautophagy R-HSA-1632852 8.196385e-03 2.086 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 8.317217e-03 2.080 0 0
Kinesins R-HSA-983189 8.413088e-03 2.075 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 8.526283e-03 2.069 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.526283e-03 2.069 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 8.526283e-03 2.069 0 0
Stabilization of p53 R-HSA-69541 8.605611e-03 2.065 0 0
SARS-CoV-1 Infection R-HSA-9678108 8.748744e-03 2.058 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 8.989487e-03 2.046 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 8.989487e-03 2.046 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 8.989487e-03 2.046 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.018985e-02 1.992 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.018985e-02 1.992 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 1.018985e-02 1.992 0 0
Translesion synthesis by POLI R-HSA-5656121 9.263042e-03 2.033 0 0
Interaction between L1 and Ankyrins R-HSA-445095 9.801167e-03 2.009 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 9.509969e-03 2.022 0 0
Chromosome Maintenance R-HSA-73886 1.002838e-02 1.999 0 0
Mitotic Prophase R-HSA-68875 9.292911e-03 2.032 0 0
Clathrin-mediated endocytosis R-HSA-8856828 1.011171e-02 1.995 1 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 1.077633e-02 1.968 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 9.801167e-03 2.009 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.087619e-02 1.964 0 0
Signaling by PDGFR in disease R-HSA-9671555 1.087619e-02 1.964 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 1.130792e-02 1.947 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.130792e-02 1.947 0 0
Signaling by NOTCH3 R-HSA-9012852 1.135211e-02 1.945 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.135211e-02 1.945 0 0
Disorders of Developmental Biology R-HSA-9675151 1.154758e-02 1.938 0 0
Translesion synthesis by POLK R-HSA-5655862 1.154758e-02 1.938 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 1.154758e-02 1.938 0 0
Signaling by NOTCH2 R-HSA-1980145 1.161671e-02 1.935 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 1.180695e-02 1.928 0 0
Signaling by Hedgehog R-HSA-5358351 1.219142e-02 1.914 1 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 1.240247e-02 1.906 0 0
Regulation of PTEN localization R-HSA-8948747 1.240247e-02 1.906 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 1.262860e-02 1.899 0 0
Interleukin-12 family signaling R-HSA-447115 1.272821e-02 1.895 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 1.287868e-02 1.890 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 1.293370e-02 1.888 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 1.293370e-02 1.888 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 1.373989e-02 1.862 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 1.373989e-02 1.862 0 0
Disorders of Nervous System Development R-HSA-9697154 1.443800e-02 1.840 0 0
Pervasive developmental disorders R-HSA-9005895 1.443800e-02 1.840 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.443800e-02 1.840 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.443800e-02 1.840 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.351797e-02 1.869 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.584590e-02 1.800 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 1.433478e-02 1.844 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.369222e-02 1.864 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 1.373507e-02 1.862 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 1.443800e-02 1.840 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 1.533905e-02 1.814 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 1.460794e-02 1.835 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.327380e-02 1.877 0 0
Autophagy R-HSA-9612973 1.332620e-02 1.875 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 1.533429e-02 1.814 1 1
ESR-mediated signaling R-HSA-8939211 1.412889e-02 1.850 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 1.510041e-02 1.821 0 0
Activation of BH3-only proteins R-HSA-114452 1.572031e-02 1.804 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.645085e-02 1.784 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 1.651428e-02 1.782 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.696797e-02 1.770 0 0
Formation of annular gap junctions R-HSA-196025 1.696797e-02 1.770 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 1.696797e-02 1.770 0 0
Modulation by Mtb of host immune system R-HSA-9637628 1.696797e-02 1.770 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 1.696797e-02 1.770 0 0
Signal Transduction R-HSA-162582 1.704549e-02 1.768 1 0
Regulation of TP53 Activity R-HSA-5633007 1.705482e-02 1.768 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 1.725620e-02 1.763 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.725620e-02 1.763 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.725620e-02 1.763 0 0
Centrosome maturation R-HSA-380287 1.726009e-02 1.763 0 0
Degradation of DVL R-HSA-4641258 1.749843e-02 1.757 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 1.817101e-02 1.741 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 1.822498e-02 1.739 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 1.822498e-02 1.739 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.913507e-02 1.718 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 1.913507e-02 1.718 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 1.930691e-02 1.714 0 0
SARS-CoV-2 Infection R-HSA-9694516 1.975106e-02 1.704 0 0
Meiosis R-HSA-1500620 2.003940e-02 1.698 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.073239e-02 1.683 0 0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 2.460272e-02 1.609 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.460272e-02 1.609 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.460272e-02 1.609 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.460272e-02 1.609 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 2.246146e-02 1.649 0 0
Gap junction degradation R-HSA-190873 2.246146e-02 1.649 0 0
ALK mutants bind TKIs R-HSA-9700645 2.246146e-02 1.649 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 2.261431e-02 1.646 0 0
Negative regulation of MET activity R-HSA-6807004 2.465443e-02 1.608 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 2.465443e-02 1.608 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 2.133373e-02 1.671 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 2.133373e-02 1.671 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.476748e-02 1.606 0 0
HDACs deacetylate histones R-HSA-3214815 2.603473e-02 1.584 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.553349e-02 1.593 0 0
DNA strand elongation R-HSA-69190 2.088377e-02 1.680 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 2.083622e-02 1.681 0 0
Metalloprotease DUBs R-HSA-5689901 2.476748e-02 1.606 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 2.261431e-02 1.646 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 2.510170e-02 1.600 0 0
Fanconi Anemia Pathway R-HSA-6783310 2.083622e-02 1.681 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 2.261996e-02 1.646 0 0
Sema4D in semaphorin signaling R-HSA-400685 2.133373e-02 1.671 0 0
ER to Golgi Anterograde Transport R-HSA-199977 2.307006e-02 1.637 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.518631e-02 1.599 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 2.088377e-02 1.680 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 2.529897e-02 1.597 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 2.356126e-02 1.628 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 2.387169e-02 1.622 0 0
Signaling by ROBO receptors R-HSA-376176 2.538050e-02 1.595 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.387169e-02 1.622 0 0
RNA Polymerase II Transcription R-HSA-73857 2.650619e-02 1.577 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 2.763575e-02 1.559 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 2.763575e-02 1.559 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 2.763575e-02 1.559 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 2.763575e-02 1.559 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 2.837379e-02 1.547 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 2.837379e-02 1.547 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 2.856188e-02 1.544 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 2.856188e-02 1.544 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 2.869070e-02 1.542 0 0
Positive Regulation of CDH1 Gene Transcription R-HSA-9764790 2.892309e-02 1.539 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 2.904279e-02 1.537 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.904279e-02 1.537 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.904279e-02 1.537 0 0
Early Phase of HIV Life Cycle R-HSA-162594 2.904279e-02 1.537 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 2.904279e-02 1.537 0 0
Breakdown of the nuclear lamina R-HSA-352238 2.918963e-02 1.535 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.446506e-02 1.463 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 3.331352e-02 1.477 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.391529e-02 1.470 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 3.391529e-02 1.470 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.391529e-02 1.470 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 3.072177e-02 1.513 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 3.170164e-02 1.499 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 3.170164e-02 1.499 0 0
snRNP Assembly R-HSA-191859 3.781609e-02 1.422 0 0
Metabolism of non-coding RNA R-HSA-194441 3.781609e-02 1.422 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 3.114886e-02 1.507 0 0
Ribosome-associated quality control R-HSA-9948299 3.716644e-02 1.430 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 3.630250e-02 1.440 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.446506e-02 1.463 0 0
Ca-dependent events R-HSA-111996 3.529110e-02 1.452 1 0
CaM pathway R-HSA-111997 3.881017e-02 1.411 1 0
Calmodulin induced events R-HSA-111933 3.881017e-02 1.411 1 1
Regulation of Apoptosis R-HSA-169911 3.460620e-02 1.461 0 0
MTOR signalling R-HSA-165159 3.529110e-02 1.452 0 0
Synthesis of DNA R-HSA-69239 3.780198e-02 1.422 0 0
Degradation of CDH1 R-HSA-9766229 3.188640e-02 1.496 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 3.872826e-02 1.412 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 3.446506e-02 1.463 0 0
HATs acetylate histones R-HSA-3214847 3.755613e-02 1.425 0 0
Signaling by NOTCH1 R-HSA-1980143 3.806519e-02 1.419 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 3.659258e-02 1.437 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 3.915010e-02 1.407 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.391529e-02 1.470 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 3.909699e-02 1.408 0 0
Cellular Senescence R-HSA-2559583 3.274454e-02 1.485 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 3.188640e-02 1.496 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 3.188640e-02 1.496 0 0
MHC class II antigen presentation R-HSA-2132295 3.774713e-02 1.423 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.872826e-02 1.412 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 3.188640e-02 1.496 0 0
Calnexin/calreticulin cycle R-HSA-901042 3.072177e-02 1.513 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.237851e-02 1.490 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.391529e-02 1.470 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 3.072177e-02 1.513 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 3.331352e-02 1.477 0 0
FLT3 signaling in disease R-HSA-9682385 3.881017e-02 1.411 0 0
Negative regulation of FLT3 R-HSA-9706369 3.331352e-02 1.477 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.391529e-02 1.470 0 0
Gap junction assembly R-HSA-190861 3.072177e-02 1.513 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.082596e-02 1.511 0 0
Interleukin-12 signaling R-HSA-9020591 3.806519e-02 1.419 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 3.928691e-02 1.406 0 0
Signaling by NOTCH R-HSA-157118 3.929026e-02 1.406 0 0
Unfolded Protein Response (UPR) R-HSA-381119 3.930442e-02 1.406 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 3.966622e-02 1.402 0 0
Protein folding R-HSA-391251 3.977155e-02 1.400 0 0
EPH-Ephrin signaling R-HSA-2682334 3.977155e-02 1.400 0 0
HIV Life Cycle R-HSA-162587 4.026226e-02 1.395 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.030477e-02 1.395 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 4.126297e-02 1.384 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 4.126297e-02 1.384 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 4.126297e-02 1.384 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 4.126297e-02 1.384 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 4.126297e-02 1.384 0 0
Regulation of PTEN gene transcription R-HSA-8943724 4.126297e-02 1.384 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 4.204144e-02 1.376 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 4.224219e-02 1.374 0 0
mRNA 3'-end processing R-HSA-72187 4.250214e-02 1.372 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 4.250214e-02 1.372 0 0
Orc1 removal from chromatin R-HSA-68949 4.250214e-02 1.372 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 4.334234e-02 1.363 0 0
Ovarian tumor domain proteases R-HSA-5689896 4.334234e-02 1.363 0 0
PCP/CE pathway R-HSA-4086400 4.433624e-02 1.353 0 0
RNA Polymerase I Transcription R-HSA-73864 4.433624e-02 1.353 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.484069e-02 1.348 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 4.484069e-02 1.348 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 4.492114e-02 1.348 0 0
Signaling by VEGF R-HSA-194138 4.499802e-02 1.347 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 4.516976e-02 1.345 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 4.516976e-02 1.345 0 0
TCR signaling R-HSA-202403 4.566520e-02 1.340 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.651908e-02 1.332 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 4.651908e-02 1.332 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 4.661060e-02 1.332 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 4.670669e-02 1.331 0 0
Glycogen storage diseases R-HSA-3229121 4.670669e-02 1.331 0 0
Signaling by TGFB family members R-HSA-9006936 4.690871e-02 1.329 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 4.760433e-02 1.322 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 4.770489e-02 1.321 0 0
Nucleosome assembly R-HSA-774815 4.770489e-02 1.321 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 4.770489e-02 1.321 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 4.770489e-02 1.321 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.786096e-02 1.320 0 0
SARS-CoV Infections R-HSA-9679506 4.803417e-02 1.318 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 4.879528e-02 1.312 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 4.901849e-02 1.310 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 4.901849e-02 1.310 0 0
Diseases of cellular response to stress R-HSA-9675132 4.901849e-02 1.310 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 4.901849e-02 1.310 0 0
Diseases of Cellular Senescence R-HSA-9630747 4.901849e-02 1.310 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.901849e-02 1.310 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 4.901849e-02 1.310 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 4.901849e-02 1.310 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 4.901849e-02 1.310 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 4.901849e-02 1.310 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 4.901849e-02 1.310 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 4.901849e-02 1.310 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 4.901849e-02 1.310 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 4.901849e-02 1.310 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 4.901849e-02 1.310 0 0
MET activates STAT3 R-HSA-8875791 7.238136e-02 1.140 0 0
MET interacts with TNS proteins R-HSA-8875513 7.238136e-02 1.140 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 5.934264e-02 1.227 0 0
Recycling of eIF2:GDP R-HSA-72731 5.934264e-02 1.227 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 7.419702e-02 1.130 0 0
Type I hemidesmosome assembly R-HSA-446107 7.419702e-02 1.130 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 7.419702e-02 1.130 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.430849e-02 1.265 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.430849e-02 1.265 0 0
Polymerase switching R-HSA-69091 5.430849e-02 1.265 0 0
Leading Strand Synthesis R-HSA-69109 5.430849e-02 1.265 0 0
CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-442720 6.477009e-02 1.189 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.444210e-02 1.264 0 0
Deadenylation of mRNA R-HSA-429947 5.157290e-02 1.288 0 0
Long-term potentiation R-HSA-9620244 5.850240e-02 1.233 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 7.394960e-02 1.131 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 5.342038e-02 1.272 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 7.324746e-02 1.135 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.897785e-02 1.229 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.241284e-02 1.281 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 5.241284e-02 1.281 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.241284e-02 1.281 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.741459e-02 1.241 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.530210e-02 1.257 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 5.196862e-02 1.284 0 0
Co-inhibition by PD-1 R-HSA-389948 5.358714e-02 1.271 0 0
Extension of Telomeres R-HSA-180786 7.597023e-02 1.119 0 0
Apoptotic factor-mediated response R-HSA-111471 5.444210e-02 1.264 0 0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 7.419702e-02 1.130 0 0
Attenuation phase R-HSA-3371568 5.897785e-02 1.229 0 0
Degradation of CRY and PER proteins R-HSA-9932298 7.114950e-02 1.148 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 7.336757e-02 1.134 0 0
Mismatch Repair R-HSA-5358508 5.444210e-02 1.264 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 6.477009e-02 1.189 0 0
UCH proteinases R-HSA-5689603 7.196021e-02 1.143 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 7.196021e-02 1.143 0 0
Nuclear Envelope Breakdown R-HSA-2980766 6.511121e-02 1.186 0 0
NOD1/2 Signaling Pathway R-HSA-168638 7.324746e-02 1.135 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 6.488665e-02 1.188 0 0
MAP2K and MAPK activation R-HSA-5674135 7.114950e-02 1.148 0 0
Signal transduction by L1 R-HSA-445144 7.199907e-02 1.143 0 0
HIV Infection R-HSA-162906 5.127341e-02 1.290 0 0
CHL1 interactions R-HSA-447041 5.934264e-02 1.227 0 0
Switching of origins to a post-replicative state R-HSA-69052 5.837050e-02 1.234 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 6.488665e-02 1.188 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.288962e-02 1.277 0 0
Signaling by PTK6 R-HSA-8848021 5.288962e-02 1.277 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.957864e-02 1.225 0 0
Glycogen synthesis R-HSA-3322077 7.199907e-02 1.143 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.488665e-02 1.188 0 0
Host Interactions of HIV factors R-HSA-162909 6.708996e-02 1.173 0 0
Assembly of the pre-replicative complex R-HSA-68867 7.578630e-02 1.120 0 0
G0 and Early G1 R-HSA-1538133 5.338129e-02 1.273 0 0
Vesicle-mediated transport R-HSA-5653656 5.315237e-02 1.274 1 0
Regulation of MITF-M dependent genes involved in metabolism R-HSA-9854907 7.238136e-02 1.140 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 5.897785e-02 1.229 0 0
PKMTs methylate histone lysines R-HSA-3214841 6.488665e-02 1.188 0 0
Intraflagellar transport R-HSA-5620924 6.271417e-02 1.203 0 0
Regulation of signaling by CBL R-HSA-912631 6.287412e-02 1.202 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.596128e-02 1.181 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 7.199907e-02 1.143 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 5.975645e-02 1.224 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 6.007666e-02 1.221 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.957864e-02 1.225 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.620009e-02 1.179 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.324746e-02 1.135 0 0
Interleukin-1 signaling R-HSA-9020702 7.476456e-02 1.126 0 0
ABC-family proteins mediated transport R-HSA-382556 7.057445e-02 1.151 0 0
Cilium Assembly R-HSA-5617833 5.270240e-02 1.278 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 5.430849e-02 1.265 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 5.430849e-02 1.265 0 0
Signaling by ERBB4 R-HSA-1236394 6.269360e-02 1.203 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 5.157290e-02 1.288 0 0
Neurodegenerative Diseases R-HSA-8863678 5.157290e-02 1.288 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 6.477009e-02 1.189 0 0
PTEN Regulation R-HSA-6807070 6.425015e-02 1.192 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.430849e-02 1.265 0 0
IRAK1 recruits IKK complex R-HSA-937039 5.430849e-02 1.265 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 6.722279e-02 1.172 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 7.394960e-02 1.131 0 0
Influenza Infection R-HSA-168255 7.568779e-02 1.121 0 0
IRE1alpha activates chaperones R-HSA-381070 6.711353e-02 1.173 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 7.199907e-02 1.143 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 7.620293e-02 1.118 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 7.620293e-02 1.118 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 7.911457e-02 1.102 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 8.072074e-02 1.093 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.072074e-02 1.093 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.072074e-02 1.093 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 8.139843e-02 1.089 0 0
XBP1(S) activates chaperone genes R-HSA-381038 8.139843e-02 1.089 0 0
Signaling by ERBB2 R-HSA-1227986 8.179802e-02 1.087 0 0
Lagging Strand Synthesis R-HSA-69186 8.180826e-02 1.087 0 0
Basigin interactions R-HSA-210991 8.180826e-02 1.087 0 0
HIV elongation arrest and recovery R-HSA-167287 8.246447e-02 1.084 0 0
Pausing and recovery of HIV elongation R-HSA-167290 8.246447e-02 1.084 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 8.246447e-02 1.084 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 8.246447e-02 1.084 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 8.412424e-02 1.075 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 8.412424e-02 1.075 0 0
APC truncation mutants are not K63 polyubiquitinated R-HSA-5467333 8.412424e-02 1.075 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 8.515594e-02 1.070 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 8.635154e-02 1.064 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.635154e-02 1.064 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 8.797405e-02 1.056 0 0
Response of endothelial cells to shear stress R-HSA-9860931 8.829836e-02 1.054 0 0
Processive synthesis on the lagging strand R-HSA-69183 8.857523e-02 1.053 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 8.857523e-02 1.053 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 8.857523e-02 1.053 0 0
Protein methylation R-HSA-8876725 8.857523e-02 1.053 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 8.857523e-02 1.053 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 8.857523e-02 1.053 0 0
Spry regulation of FGF signaling R-HSA-1295596 8.857523e-02 1.053 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 8.861806e-02 1.052 0 0
RNA Polymerase III Transcription R-HSA-74158 8.861806e-02 1.052 0 0
HSF1 activation R-HSA-3371511 8.861806e-02 1.052 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 8.861806e-02 1.052 0 0
Formation of a pool of free 40S subunits R-HSA-72689 9.010452e-02 1.045 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 9.051860e-02 1.043 0 0
GP1b-IX-V activation signalling R-HSA-430116 9.051860e-02 1.043 0 0
Unwinding of DNA R-HSA-176974 9.051860e-02 1.043 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 9.051860e-02 1.043 0 0
Cellular response to mitochondrial stress R-HSA-9840373 9.051860e-02 1.043 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 9.051860e-02 1.043 0 0
Late endosomal microautophagy R-HSA-9615710 9.150022e-02 1.039 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 9.150022e-02 1.039 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.207061e-02 1.036 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 9.228826e-02 1.035 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 9.310480e-02 1.031 0 0
Regulation of PTEN stability and activity R-HSA-8948751 9.375778e-02 1.028 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 9.392572e-02 1.027 0 0
Regulation of mitotic cell cycle R-HSA-453276 9.392572e-02 1.027 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 9.564277e-02 1.019 0 0
Degradation of AXIN R-HSA-4641257 9.693575e-02 1.014 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 9.693575e-02 1.014 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 9.693575e-02 1.014 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 9.854420e-02 1.006 0 0
SARS-CoV-2 targets PDZ proteins in cell-cell junction R-HSA-9705677 9.854420e-02 1.006 0 0
NADE modulates death signalling R-HSA-205025 9.854420e-02 1.006 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.975164e-02 1.001 0 0
DAG and IP3 signaling R-HSA-1489509 9.975164e-02 1.001 1 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.975164e-02 1.001 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.975164e-02 1.001 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.001139e-01 1.000 0 0
Telomere Maintenance R-HSA-157579 1.005316e-01 0.998 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 1.008787e-01 0.996 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.008801e-01 0.996 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 1.010485e-01 0.995 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 1.018472e-01 0.992 0 0
Regulation of BACH1 activity R-HSA-9708530 1.018472e-01 0.992 0 0
Downstream TCR signaling R-HSA-202424 1.027881e-01 0.988 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 1.034213e-01 0.985 0 0
Notch-HLH transcription pathway R-HSA-350054 1.034213e-01 0.985 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 1.034213e-01 0.985 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 1.065377e-01 0.972 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.077712e-01 0.967 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.077815e-01 0.967 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 1.081822e-01 0.966 0 0
2-LTR circle formation R-HSA-164843 1.081822e-01 0.966 0 0
Interleukin-27 signaling R-HSA-9020956 1.081822e-01 0.966 0 0
Trafficking of AMPA receptors R-HSA-399719 1.110983e-01 0.954 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 1.110983e-01 0.954 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 1.146394e-01 0.941 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 1.148090e-01 0.940 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 1.148090e-01 0.940 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 1.148090e-01 0.940 0 0
Plasma lipoprotein clearance R-HSA-8964043 1.148090e-01 0.940 0 0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 1.159721e-01 0.936 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 1.159721e-01 0.936 0 0
Signaling by EGFR R-HSA-177929 1.160199e-01 0.935 0 0
TNF signaling R-HSA-75893 1.160199e-01 0.935 0 0
Viral Infection Pathways R-HSA-9824446 1.160427e-01 0.935 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.161554e-01 0.935 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 1.195736e-01 0.922 0 0
Interleukin-1 family signaling R-HSA-446652 1.201827e-01 0.920 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 1.201827e-01 0.920 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.208517e-01 0.918 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 1.240330e-01 0.906 0 0
HIV Transcription Elongation R-HSA-167169 1.243487e-01 0.905 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 1.243487e-01 0.905 0 0
DNA Replication R-HSA-69306 1.250487e-01 0.903 0 0
Pyrophosphate hydrolysis R-HSA-71737 1.268713e-01 0.897 0 0
Bicarbonate transporters R-HSA-425381 1.270542e-01 0.896 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 1.275556e-01 0.894 0 0
TCF dependent signaling in response to WNT R-HSA-201681 1.298969e-01 0.886 0 0
Regulation of PAK-2p34 activity by PS-GAP/RHG10 R-HSA-211728 1.611762e-01 0.793 0 0
Drug-mediated inhibition of MET activation R-HSA-9734091 1.611762e-01 0.793 0 0
Diseases of Telomere Maintenance R-HSA-9673013 1.611762e-01 0.793 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 1.611762e-01 0.793 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 1.611762e-01 0.793 0 0
Hereditary fructose intolerance R-HSA-5657560 1.611762e-01 0.793 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 1.611762e-01 0.793 0 0
Defective DNA double strand break response due to BRCA1 loss of function R-HSA-9663199 1.611762e-01 0.793 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 1.611762e-01 0.793 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 1.611762e-01 0.793 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 1.611762e-01 0.793 0 0
Defective DNA double strand break response due to BARD1 loss of function R-HSA-9699150 1.611762e-01 0.793 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 1.611762e-01 0.793 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 2.317500e-01 0.635 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 2.317500e-01 0.635 0 0
Defective SLC26A2 causes chondrodysplasias R-HSA-3560792 2.317500e-01 0.635 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 2.317500e-01 0.635 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 2.317500e-01 0.635 0 0
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) R-HSA-5619054 2.317500e-01 0.635 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 2.317500e-01 0.635 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 1.568139e-01 0.805 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 1.568139e-01 0.805 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 1.568139e-01 0.805 0 0
Signaling by LTK in cancer R-HSA-9842640 1.879003e-01 0.726 0 0
Autointegration results in viral DNA circles R-HSA-177539 1.879003e-01 0.726 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.469967e-01 0.833 0 0
MECP2 regulates transcription factors R-HSA-9022707 2.197266e-01 0.658 0 0
MET activates PI3K/AKT signaling R-HSA-8851907 2.197266e-01 0.658 0 0
Repression of WNT target genes R-HSA-4641265 1.678702e-01 0.775 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 1.308978e-01 0.883 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 1.308978e-01 0.883 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 1.465675e-01 0.834 0 0
PKA activation R-HSA-163615 1.465675e-01 0.834 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 1.629209e-01 0.788 0 0
Removal of the Flap Intermediate R-HSA-69166 2.118612e-01 0.674 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 1.680025e-01 0.775 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 1.680025e-01 0.775 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.441126e-01 0.841 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 2.579699e-01 0.588 0 0
Phosphorylation of the APC/C R-HSA-176412 2.579699e-01 0.588 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 1.824853e-01 0.739 0 0
Formation of the Early Elongation Complex R-HSA-113418 1.824853e-01 0.739 0 0
RAF activation R-HSA-5673000 1.560139e-01 0.807 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 2.338961e-01 0.631 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 2.527051e-01 0.597 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 2.527051e-01 0.597 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 1.323349e-01 0.878 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 1.629439e-01 0.788 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 2.212677e-01 0.655 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 1.460963e-01 0.835 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 2.012801e-01 0.696 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 2.352946e-01 0.628 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.406175e-01 0.852 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.762086e-01 0.754 0 0
Post-translational protein phosphorylation R-HSA-8957275 1.695167e-01 0.771 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 2.517267e-01 0.599 0 0
Signaling by MET R-HSA-6806834 2.504000e-01 0.601 0 0
EGFR downregulation R-HSA-182971 2.284178e-01 0.641 0 0
Integration of provirus R-HSA-162592 1.469967e-01 0.833 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 1.974260e-01 0.705 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 1.469967e-01 0.833 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 1.895367e-01 0.722 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 1.445836e-01 0.840 0 0
DARPP-32 events R-HSA-180024 1.974078e-01 0.705 0 0
GAB1 signalosome R-HSA-180292 1.465675e-01 0.834 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 2.579699e-01 0.588 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.432777e-01 0.844 0 0
Molecules associated with elastic fibres R-HSA-2129379 2.284178e-01 0.641 0 0
Nuclear RNA decay R-HSA-9930044 2.607177e-01 0.584 0 0
Eukaryotic Translation Termination R-HSA-72764 1.475753e-01 0.831 0 0
Peptide chain elongation R-HSA-156902 2.387495e-01 0.622 0 0
Cyclin D associated events in G1 R-HSA-69231 1.776305e-01 0.750 0 0
G1 Phase R-HSA-69236 1.776305e-01 0.750 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.484053e-01 0.605 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 1.529587e-01 0.815 0 0
PLC beta mediated events R-HSA-112043 1.589132e-01 0.799 1 0
Interactions of Rev with host cellular proteins R-HSA-177243 2.352946e-01 0.628 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 2.352946e-01 0.628 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 1.683063e-01 0.774 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 1.678702e-01 0.775 0 0
Translation R-HSA-72766 2.092184e-01 0.679 0 0
Activation and oligomerization of BAK protein R-HSA-111452 1.611762e-01 0.793 0 0
Reduction of cytosolic Ca++ levels R-HSA-418359 1.469967e-01 0.833 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 1.308978e-01 0.883 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 2.519484e-01 0.599 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 2.519484e-01 0.599 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 1.405031e-01 0.852 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.607177e-01 0.584 0 0
ER-Phagosome pathway R-HSA-1236974 1.603554e-01 0.795 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 1.441126e-01 0.841 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 1.678702e-01 0.775 0 0
DNA Replication Pre-Initiation R-HSA-69002 1.851021e-01 0.733 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 1.970776e-01 0.705 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 2.403569e-01 0.619 0 0
G-protein mediated events R-HSA-112040 2.188768e-01 0.660 1 0
Interleukin-23 signaling R-HSA-9020933 2.519484e-01 0.599 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 1.547131e-01 0.810 0 0
Neurofascin interactions R-HSA-447043 1.879003e-01 0.726 0 0
Signaling by FGFR1 in disease R-HSA-5655302 1.445836e-01 0.840 0 0
Circadian clock R-HSA-9909396 2.360207e-01 0.627 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 2.338961e-01 0.631 0 0
Interleukin-35 Signalling R-HSA-8984722 1.678702e-01 0.775 0 0
RAF/MAP kinase cascade R-HSA-5673001 2.524506e-01 0.598 0 0
HDMs demethylate histones R-HSA-3214842 1.405031e-01 0.852 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.537271e-01 0.813 1 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 1.326469e-01 0.877 0 0
MAPK family signaling cascades R-HSA-5683057 1.736546e-01 0.760 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 1.611762e-01 0.793 0 0
Activation, translocation and oligomerization of BAX R-HSA-114294 1.611762e-01 0.793 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 2.317500e-01 0.635 0 0
Manipulation of host energy metabolism R-HSA-9636667 2.317500e-01 0.635 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 1.308978e-01 0.883 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 2.347137e-01 0.629 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 2.347137e-01 0.629 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 2.579699e-01 0.588 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 1.974078e-01 0.705 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 1.425496e-01 0.846 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 1.539966e-01 0.812 0 0
Neurexins and neuroligins R-HSA-6794361 1.629439e-01 0.788 0 0
Interleukin-9 signaling R-HSA-8985947 2.519484e-01 0.599 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 1.342775e-01 0.872 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 2.347137e-01 0.629 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 2.347137e-01 0.629 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.607177e-01 0.584 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.927375e-01 0.715 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.927375e-01 0.715 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.560912e-01 0.807 0 0
Signal regulatory protein family interactions R-HSA-391160 2.118612e-01 0.674 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 2.579699e-01 0.588 0 0
Glycogen metabolism R-HSA-8982491 2.352946e-01 0.628 0 0
Mitophagy R-HSA-5205647 1.560139e-01 0.807 0 0
Signaling by ALK R-HSA-201556 2.212677e-01 0.655 0 0
RMTs methylate histone arginines R-HSA-3214858 1.776305e-01 0.750 0 0
Generic Transcription Pathway R-HSA-212436 1.562910e-01 0.806 0 0
Developmental Biology R-HSA-1266738 1.538981e-01 0.813 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 2.352946e-01 0.628 0 0
Hedgehog 'on' state R-HSA-5632684 1.631540e-01 0.787 1 0
Reproduction R-HSA-1474165 1.514812e-01 0.820 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 1.879003e-01 0.726 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.629209e-01 0.788 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.326469e-01 0.877 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 1.560139e-01 0.807 0 0
RAS processing R-HSA-9648002 2.212677e-01 0.655 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 2.212677e-01 0.655 0 0
Activation of ATR in response to replication stress R-HSA-176187 2.607177e-01 0.584 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 1.720309e-01 0.764 0 0
Interleukin-6 signaling R-HSA-1059683 1.895367e-01 0.722 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 1.545070e-01 0.811 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 2.348713e-01 0.629 0 0
Ion homeostasis R-HSA-5578775 2.056994e-01 0.687 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.939184e-01 0.712 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.326469e-01 0.877 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.338961e-01 0.631 0 0
G1/S Transition R-HSA-69206 1.773442e-01 0.751 0 0
Ephrin signaling R-HSA-3928664 1.465675e-01 0.834 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 2.558610e-01 0.592 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 2.558610e-01 0.592 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 2.558610e-01 0.592 0 0
Role of ABL in ROBO-SLIT signaling R-HSA-428890 2.197266e-01 0.658 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.680025e-01 0.775 0 0
Assembly Of The HIV Virion R-HSA-175474 2.154481e-01 0.667 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.284178e-01 0.641 0 0
Diseases of programmed cell death R-HSA-9645723 2.387495e-01 0.622 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 2.075317e-01 0.683 0 0
Cellular response to chemical stress R-HSA-9711123 1.973346e-01 0.705 0 0
Signaling by KIT in disease R-HSA-9669938 2.338961e-01 0.631 0 0
STING mediated induction of host immune responses R-HSA-1834941 1.629209e-01 0.788 0 0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-HSA-6803205 2.338961e-01 0.631 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 2.197266e-01 0.658 0 0
Syndecan interactions R-HSA-3000170 2.527051e-01 0.597 0 0
FLT3 Signaling R-HSA-9607240 1.342775e-01 0.872 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 1.974260e-01 0.705 0 0
Response of Mtb to phagocytosis R-HSA-9637690 1.662749e-01 0.779 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 2.519484e-01 0.599 0 0
Interleukin-37 signaling R-HSA-9008059 2.127317e-01 0.672 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.631540e-01 0.787 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.056994e-01 0.687 0 0
Amyloid fiber formation R-HSA-977225 2.609834e-01 0.583 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.641124e-01 0.578 0 0
Translation of Structural Proteins R-HSA-9683701 2.641124e-01 0.578 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 2.644799e-01 0.578 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 2.676195e-01 0.572 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 2.717094e-01 0.566 0 0
tRNA processing in the nucleus R-HSA-6784531 2.768007e-01 0.558 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.788484e-01 0.555 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 2.815126e-01 0.551 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.815126e-01 0.551 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 2.815126e-01 0.551 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.815126e-01 0.551 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 2.815126e-01 0.551 0 0
ARMS-mediated activation R-HSA-170984 2.842743e-01 0.546 0 0
AKT phosphorylates targets in the nucleus R-HSA-198693 2.842743e-01 0.546 0 0
WNT mediated activation of DVL R-HSA-201688 2.842743e-01 0.546 0 0
Calcineurin activates NFAT R-HSA-2025928 2.842743e-01 0.546 0 0
Activation of RAC1 downstream of NMDARs R-HSA-9619229 2.842743e-01 0.546 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 2.842743e-01 0.546 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 2.842743e-01 0.546 0 0
Interleukin-21 signaling R-HSA-9020958 2.842743e-01 0.546 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 2.842743e-01 0.546 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 2.842743e-01 0.546 0 0
Developmental Cell Lineages R-HSA-9734767 2.891687e-01 0.539 0 0
Acyl chain remodelling of PS R-HSA-1482801 2.911529e-01 0.536 0 0
TGFBR3 expression R-HSA-9839394 2.911529e-01 0.536 0 0
Interleukin-7 signaling R-HSA-1266695 2.911529e-01 0.536 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.925564e-01 0.534 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.939895e-01 0.532 0 0
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 2.963899e-01 0.528 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 2.963899e-01 0.528 0 0
Mitotic Metaphase/Anaphase Transition R-HSA-68881 2.963899e-01 0.528 0 0
Glycogen storage disease type XV (GYG1) R-HSA-3814836 2.963899e-01 0.528 0 0
Glycogen storage disease type 0 (muscle GYS1) R-HSA-3828062 2.963899e-01 0.528 0 0
mRNA Editing: A to I Conversion R-HSA-75064 2.963899e-01 0.528 0 0
C6 deamination of adenosine R-HSA-75102 2.963899e-01 0.528 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 2.963899e-01 0.528 0 0
Signaling by FGFR in disease R-HSA-1226099 2.977941e-01 0.526 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 3.052319e-01 0.515 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 3.052319e-01 0.515 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 3.052319e-01 0.515 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 3.087006e-01 0.510 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 3.106691e-01 0.508 0 0
Myogenesis R-HSA-525793 3.106691e-01 0.508 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.106691e-01 0.508 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.106691e-01 0.508 0 0
Suppression of phagosomal maturation R-HSA-9637687 3.106691e-01 0.508 0 0
PERK regulates gene expression R-HSA-381042 3.108916e-01 0.507 0 0
Cellular response to hypoxia R-HSA-1234174 3.146100e-01 0.502 0 0
Folding of actin by CCT/TriC R-HSA-390450 3.164590e-01 0.500 0 0
Regulation of the apoptosome activity R-HSA-9627069 3.164590e-01 0.500 0 0
Regulation of CDH11 function R-HSA-9762292 3.164590e-01 0.500 0 0
Formation of apoptosome R-HSA-111458 3.164590e-01 0.500 0 0
PI3K/AKT activation R-HSA-198203 3.164590e-01 0.500 0 0
Binding and entry of HIV virion R-HSA-173107 3.164590e-01 0.500 0 0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-5140745 3.164590e-01 0.500 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 3.164590e-01 0.500 0 0
Signaling by Leptin R-HSA-2586552 3.164590e-01 0.500 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 3.164590e-01 0.500 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 3.271123e-01 0.485 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.279203e-01 0.484 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 3.285316e-01 0.483 0 0
Polo-like kinase mediated events R-HSA-156711 3.290256e-01 0.483 0 0
PKA activation in glucagon signalling R-HSA-164378 3.290256e-01 0.483 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 3.290256e-01 0.483 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.303021e-01 0.481 0 0
NRAGE signals death through JNK R-HSA-193648 3.333955e-01 0.477 0 0
Translation of Structural Proteins R-HSA-9694635 3.336015e-01 0.477 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 3.339503e-01 0.476 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 3.383408e-01 0.471 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 3.383408e-01 0.471 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.393333e-01 0.469 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 3.448968e-01 0.462 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 3.450383e-01 0.462 0 0
ABC transporter disorders R-HSA-5619084 3.457077e-01 0.461 0 0
PECAM1 interactions R-HSA-210990 3.482974e-01 0.458 0 0
Formation of the posterior neural plate R-HSA-9832991 3.482974e-01 0.458 0 0
Synthesis of PI R-HSA-1483226 3.482974e-01 0.458 0 0
vRNP Assembly R-HSA-192905 3.482974e-01 0.458 0 0
Suppression of apoptosis R-HSA-9635465 3.482974e-01 0.458 0 0
Telomere Extension By Telomerase R-HSA-171319 3.499964e-01 0.456 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 3.499964e-01 0.456 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 3.527996e-01 0.452 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 3.527996e-01 0.452 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 3.527996e-01 0.452 0 0
The NLRP3 inflammasome R-HSA-844456 3.527996e-01 0.452 0 0
Rap1 signalling R-HSA-392517 3.527996e-01 0.452 0 0
Other interleukin signaling R-HSA-449836 3.527996e-01 0.452 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.533442e-01 0.452 0 0
Transcription of the HIV genome R-HSA-167172 3.533535e-01 0.452 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 3.533535e-01 0.452 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 3.533535e-01 0.452 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 3.547051e-01 0.450 0 0
Axonal growth stimulation R-HSA-209563 3.555947e-01 0.449 0 0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome R-HSA-9944997 3.555947e-01 0.449 0 0
3-Methylcrotonyl-CoA carboxylase deficiency R-HSA-9909438 3.555947e-01 0.449 0 0
Signalling to STAT3 R-HSA-198745 3.555947e-01 0.449 0 0
Loss of Function of KMT2D in Kabuki Syndrome R-HSA-9944971 3.555947e-01 0.449 0 0
MET activates PTPN11 R-HSA-8865999 3.555947e-01 0.449 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 3.555947e-01 0.449 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 3.555947e-01 0.449 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 3.555947e-01 0.449 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 3.559387e-01 0.449 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 3.622097e-01 0.441 0 0
Elastic fibre formation R-HSA-1566948 3.622097e-01 0.441 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.622097e-01 0.441 0 0
Antigen processing-Cross presentation R-HSA-1236975 3.663424e-01 0.436 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 3.663424e-01 0.436 0 0
Platelet degranulation R-HSA-114608 3.694961e-01 0.432 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.696994e-01 0.432 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.696994e-01 0.432 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 3.696994e-01 0.432 0 0
mRNA Capping R-HSA-72086 3.696994e-01 0.432 0 0
Platelet calcium homeostasis R-HSA-418360 3.696994e-01 0.432 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 3.696994e-01 0.432 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 3.701248e-01 0.432 0 0
Signaling by WNT R-HSA-195721 3.725050e-01 0.429 0 0
Base Excision Repair R-HSA-73884 3.729195e-01 0.428 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.764679e-01 0.424 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.764679e-01 0.424 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.764679e-01 0.424 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.764679e-01 0.424 0 0
Nephrin family interactions R-HSA-373753 3.764679e-01 0.424 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 3.767865e-01 0.424 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.793998e-01 0.421 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.796203e-01 0.421 0 0
Proton-coupled monocarboxylate transport R-HSA-433692 3.796203e-01 0.421 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 3.796203e-01 0.421 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 3.796203e-01 0.421 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 3.796203e-01 0.421 0 0
Activation of RAC1 R-HSA-428540 3.796203e-01 0.421 0 0
Cellular response to starvation R-HSA-9711097 3.808695e-01 0.419 0 0
Glycolysis R-HSA-70171 3.860793e-01 0.413 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 3.881327e-01 0.411 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 3.881327e-01 0.411 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 3.893613e-01 0.410 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 3.893613e-01 0.410 0 0
Sphingolipid de novo biosynthesis R-HSA-1660661 3.897187e-01 0.409 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 3.965754e-01 0.402 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.965754e-01 0.402 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.965754e-01 0.402 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 3.965754e-01 0.402 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.970870e-01 0.401 0 0
Selenocysteine synthesis R-HSA-2408557 3.970870e-01 0.401 0 0
MAP kinase activation R-HSA-450294 4.038620e-01 0.394 0 0
Budding and maturation of HIV virion R-HSA-162588 4.089354e-01 0.388 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 4.098209e-01 0.387 0 0
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119 4.098209e-01 0.387 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 4.098209e-01 0.387 0 0
Regulation of gap junction activity R-HSA-191650 4.098209e-01 0.387 0 0
AKT-mediated inactivation of FOXO1A R-HSA-211163 4.098209e-01 0.387 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 4.102889e-01 0.387 0 0
Scavenging by Class F Receptors R-HSA-3000484 4.102889e-01 0.387 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 4.102889e-01 0.387 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.102889e-01 0.387 0 0
OAS antiviral response R-HSA-8983711 4.102889e-01 0.387 0 0
Reversal of alkylation damage by DNA dioxygenases R-HSA-73943 4.102889e-01 0.387 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 4.137045e-01 0.383 0 0
Heme signaling R-HSA-9707616 4.179932e-01 0.379 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 4.183568e-01 0.378 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 4.183568e-01 0.378 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 4.188125e-01 0.378 0 0
Viral mRNA Translation R-HSA-192823 4.191429e-01 0.378 0 0
Diseases of mitotic cell cycle R-HSA-9675126 4.283781e-01 0.368 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 4.284491e-01 0.368 0 0
Opioid Signalling R-HSA-111885 4.301736e-01 0.366 1 0
Signaling by Nuclear Receptors R-HSA-9006931 4.307321e-01 0.366 0 0
Intra-Golgi traffic R-HSA-6811438 4.307571e-01 0.366 0 0
Protein-protein interactions at synapses R-HSA-6794362 4.315272e-01 0.365 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.401919e-01 0.356 0 0
CD28 dependent Vav1 pathway R-HSA-389359 4.401919e-01 0.356 0 0
Replication of the SARS-CoV-1 genome R-HSA-9682706 4.401919e-01 0.356 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.436436e-01 0.353 0 0
Iron uptake and transport R-HSA-917937 4.450224e-01 0.352 0 0
LDL clearance R-HSA-8964038 4.460958e-01 0.351 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 4.476491e-01 0.349 0 0
Integrin signaling R-HSA-354192 4.476491e-01 0.349 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 4.476491e-01 0.349 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 4.476491e-01 0.349 0 0
Neutrophil degranulation R-HSA-6798695 4.592516e-01 0.338 0 0
IRS activation R-HSA-74713 4.594870e-01 0.338 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 4.594870e-01 0.338 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 4.594870e-01 0.338 0 0
PTK6 Activates STAT3 R-HSA-8849474 4.594870e-01 0.338 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 4.594870e-01 0.338 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 4.594870e-01 0.338 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.594870e-01 0.338 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 4.594870e-01 0.338 0 0
Muscarinic acetylcholine receptors R-HSA-390648 4.594870e-01 0.338 0 0
Inositol transporters R-HSA-429593 4.594870e-01 0.338 0 0
NrCAM interactions R-HSA-447038 4.594870e-01 0.338 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 4.594870e-01 0.338 0 0
Assembly of Viral Components at the Budding Site R-HSA-168316 4.594870e-01 0.338 0 0
Signaling by FGFR4 R-HSA-5654743 4.645196e-01 0.333 0 0
Signaling by SCF-KIT R-HSA-1433557 4.645196e-01 0.333 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 4.667111e-01 0.331 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.686366e-01 0.329 0 0
Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9648895 4.686366e-01 0.329 0 0
Growth hormone receptor signaling R-HSA-982772 4.686366e-01 0.329 0 0
Retrograde neurotrophin signalling R-HSA-177504 4.692408e-01 0.329 0 0
Non-canonical inflammasome activation R-HSA-9686114 4.692408e-01 0.329 0 0
SARS-CoV-1 Genome Replication and Transcription R-HSA-9679514 4.692408e-01 0.329 0 0
Integrin cell surface interactions R-HSA-216083 4.839088e-01 0.315 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 4.855301e-01 0.314 0 0
Nuclear import of Rev protein R-HSA-180746 4.855301e-01 0.314 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 4.855301e-01 0.314 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 4.855301e-01 0.314 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 4.855301e-01 0.314 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 4.855301e-01 0.314 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.855425e-01 0.314 0 0
SLC-mediated transport of amino acids R-HSA-9958863 4.878740e-01 0.312 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.907562e-01 0.309 0 0
Processing of Capped Intronless Pre-mRNA R-HSA-75067 4.907562e-01 0.309 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 4.907562e-01 0.309 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 4.907562e-01 0.309 0 0
Interleukin-6 family signaling R-HSA-6783589 4.907562e-01 0.309 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 4.918191e-01 0.308 0 0
Sensory processing of sound R-HSA-9659379 4.967214e-01 0.304 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 4.973677e-01 0.303 0 0
Other semaphorin interactions R-HSA-416700 4.973677e-01 0.303 0 0
Formation of the anterior neural plate R-HSA-9823739 4.973677e-01 0.303 0 0
DNA Damage Reversal R-HSA-73942 4.973677e-01 0.303 0 0
Signaling by FGFR3 R-HSA-5654741 4.976544e-01 0.303 0 0
FOXO-mediated transcription R-HSA-9614085 4.999316e-01 0.301 0 0
Regulated Necrosis R-HSA-5218859 5.015856e-01 0.300 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.025083e-01 0.299 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.040751e-01 0.298 0 0
Nef Mediated CD8 Down-regulation R-HSA-182218 5.049761e-01 0.297 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 5.049761e-01 0.297 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 5.049761e-01 0.297 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 5.049761e-01 0.297 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 5.049761e-01 0.297 0 0
PKA-mediated phosphorylation of key metabolic factors R-HSA-163358 5.049761e-01 0.297 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 5.049761e-01 0.297 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 5.049761e-01 0.297 0 0
Cam-PDE 1 activation R-HSA-111957 5.049761e-01 0.297 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 5.049761e-01 0.297 0 0
Phosphorylation of Emi1 R-HSA-176417 5.049761e-01 0.297 0 0
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.049761e-01 0.297 0 0
Sodium-coupled phosphate cotransporters R-HSA-427652 5.049761e-01 0.297 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.049761e-01 0.297 0 0
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919 5.049761e-01 0.297 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 5.094396e-01 0.293 0 0
Potential therapeutics for SARS R-HSA-9679191 5.102507e-01 0.292 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.124125e-01 0.290 0 0
Diseases of DNA repair R-HSA-9675135 5.139288e-01 0.289 0 0
Signaling by TGFBR3 R-HSA-9839373 5.139288e-01 0.289 0 0
HCMV Early Events R-HSA-9609690 5.212378e-01 0.283 0 0
RET signaling R-HSA-8853659 5.223181e-01 0.282 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.245222e-01 0.280 0 0
Killing mechanisms R-HSA-9664420 5.245222e-01 0.280 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.245222e-01 0.280 0 0
Prolonged ERK activation events R-HSA-169893 5.245222e-01 0.280 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.245222e-01 0.280 0 0
Interleukin-17 signaling R-HSA-448424 5.286312e-01 0.277 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.299805e-01 0.276 0 0
MET activates PTK2 signaling R-HSA-8874081 5.335696e-01 0.273 0 0
Transmission across Chemical Synapses R-HSA-112315 5.353185e-01 0.271 0 0
Peroxisomal protein import R-HSA-9033241 5.363734e-01 0.271 0 0
Amino acid transport across the plasma membrane R-HSA-352230 5.363734e-01 0.271 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 5.398576e-01 0.268 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 5.398576e-01 0.268 0 0
Co-stimulation by CD28 R-HSA-389356 5.457912e-01 0.263 0 0
NGF-stimulated transcription R-HSA-9031628 5.457912e-01 0.263 0 0
Gluconeogenesis R-HSA-70263 5.457912e-01 0.263 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 5.466394e-01 0.262 0 0
Erythropoietin activates STAT5 R-HSA-9027283 5.466394e-01 0.262 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.466394e-01 0.262 0 0
Defective CHST3 causes SEDCJD R-HSA-3595172 5.466394e-01 0.262 0 0
Defective CHST14 causes EDS, musculocontractural type R-HSA-3595174 5.466394e-01 0.262 0 0
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-5619070 5.466394e-01 0.262 0 0
MET Receptor Activation R-HSA-6806942 5.466394e-01 0.262 0 0
Abacavir transmembrane transport R-HSA-2161517 5.466394e-01 0.262 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.466394e-01 0.262 0 0
Nef and signal transduction R-HSA-164944 5.466394e-01 0.262 0 0
VLDL assembly R-HSA-8866423 5.466394e-01 0.262 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 5.466394e-01 0.262 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 5.469220e-01 0.262 0 0
Adaptive Immune System R-HSA-1280218 5.475011e-01 0.262 0 0
Processing of Intronless Pre-mRNAs R-HSA-77595 5.506686e-01 0.259 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.506686e-01 0.259 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.506686e-01 0.259 0 0
Packaging Of Telomere Ends R-HSA-171306 5.541972e-01 0.256 0 0
Cristae formation R-HSA-8949613 5.541972e-01 0.256 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 5.541972e-01 0.256 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.541972e-01 0.256 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 5.550923e-01 0.256 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.578014e-01 0.254 0 0
Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.578014e-01 0.254 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.685932e-01 0.245 0 0
Inflammasomes R-HSA-622312 5.742703e-01 0.241 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 5.750002e-01 0.240 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 5.757844e-01 0.240 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.757844e-01 0.240 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 5.757844e-01 0.240 0 0
Specification of primordial germ cells R-HSA-9827857 5.757844e-01 0.240 0 0
Replication of the SARS-CoV-2 genome R-HSA-9694686 5.757844e-01 0.240 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.847984e-01 0.233 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 5.847984e-01 0.233 0 0
Defective CHSY1 causes TPBS R-HSA-3595177 5.847984e-01 0.233 0 0
SOS-mediated signalling R-HSA-112412 5.847984e-01 0.233 0 0
SLBP independent Processing of Histone Pre-mRNAs R-HSA-111367 5.847984e-01 0.233 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 5.847984e-01 0.233 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 5.847984e-01 0.233 0 0
PTK6 Expression R-HSA-8849473 5.847984e-01 0.233 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 5.847984e-01 0.233 0 0
Disinhibition of SNARE formation R-HSA-114516 5.847984e-01 0.233 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 5.847984e-01 0.233 0 0
LDL remodeling R-HSA-8964041 5.847984e-01 0.233 0 0
VLDL clearance R-HSA-8964046 5.847984e-01 0.233 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 5.847984e-01 0.233 0 0
Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 5.847984e-01 0.233 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.847984e-01 0.233 0 0
Meiotic recombination R-HSA-912446 5.916186e-01 0.228 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.918137e-01 0.228 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 5.918137e-01 0.228 0 0
Diseases of Immune System R-HSA-5260271 5.918137e-01 0.228 0 0
Interleukin-2 family signaling R-HSA-451927 5.918137e-01 0.228 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 5.998577e-01 0.222 0 0
Platelet sensitization by LDL R-HSA-432142 5.998577e-01 0.222 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 5.998577e-01 0.222 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 5.998577e-01 0.222 0 0
Glucose metabolism R-HSA-70326 6.002319e-01 0.222 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 6.014329e-01 0.221 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 6.021019e-01 0.220 0 0
Ion transport by P-type ATPases R-HSA-936837 6.057318e-01 0.218 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 6.063146e-01 0.217 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.101207e-01 0.215 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 6.126778e-01 0.213 0 0
Activation of the pre-replicative complex R-HSA-68962 6.126778e-01 0.213 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 6.126778e-01 0.213 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 6.126778e-01 0.213 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 6.126778e-01 0.213 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 6.197477e-01 0.208 0 0
phospho-PLA2 pathway R-HSA-111995 6.197477e-01 0.208 0 0
MET receptor recycling R-HSA-8875656 6.197477e-01 0.208 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 6.197477e-01 0.208 0 0
Activated NTRK2 signals through PI3K R-HSA-9028335 6.197477e-01 0.208 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 6.197477e-01 0.208 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 6.197477e-01 0.208 0 0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-77588 6.197477e-01 0.208 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 6.197477e-01 0.208 0 0
Co-stimulation by ICOS R-HSA-9927354 6.197477e-01 0.208 0 0
Adrenoceptors R-HSA-390696 6.197477e-01 0.208 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 6.197477e-01 0.208 0 0
TGFBR3 PTM regulation R-HSA-9839383 6.197477e-01 0.208 0 0
Sodium/Proton exchangers R-HSA-425986 6.197477e-01 0.208 0 0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866904 6.197477e-01 0.208 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 6.228862e-01 0.206 0 0
Maturation of nucleoprotein R-HSA-9694631 6.228862e-01 0.206 0 0
SARS-CoV-2 Genome Replication and Transcription R-HSA-9694682 6.228862e-01 0.206 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 6.239633e-01 0.205 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 6.242307e-01 0.205 0 0
HIV Transcription Initiation R-HSA-167161 6.242307e-01 0.205 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 6.242307e-01 0.205 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 6.309854e-01 0.200 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 6.309854e-01 0.200 0 0
Downstream signal transduction R-HSA-186763 6.309854e-01 0.200 0 0
Post-translational protein modification R-HSA-597592 6.363230e-01 0.196 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.398125e-01 0.194 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 6.398125e-01 0.194 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 6.398125e-01 0.194 0 0
Depyrimidination R-HSA-73928 6.398125e-01 0.194 0 0
Protein localization R-HSA-9609507 6.403029e-01 0.194 0 0
Regulation of PD-L1(CD274) translation R-HSA-9909620 6.448751e-01 0.191 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 6.448751e-01 0.191 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.448751e-01 0.191 0 0
Protein hydroxylation R-HSA-9629569 6.448751e-01 0.191 0 0
Formation of definitive endoderm R-HSA-9823730 6.448751e-01 0.191 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 6.486840e-01 0.188 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 6.486840e-01 0.188 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 6.517571e-01 0.186 0 0
Lipophagy R-HSA-9613354 6.517571e-01 0.186 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 6.517571e-01 0.186 0 0
p75NTR regulates axonogenesis R-HSA-193697 6.517571e-01 0.186 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 6.517571e-01 0.186 0 0
mRNA Editing R-HSA-75072 6.517571e-01 0.186 0 0
Regulation of signaling by NODAL R-HSA-1433617 6.517571e-01 0.186 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 6.517571e-01 0.186 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 6.517571e-01 0.186 0 0
Interleukin-1 processing R-HSA-448706 6.517571e-01 0.186 0 0
Regulated proteolysis of p75NTR R-HSA-193692 6.517571e-01 0.186 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 6.517571e-01 0.186 0 0
Defects in biotin (Btn) metabolism R-HSA-3323169 6.517571e-01 0.186 0 0
Signaling by FGFR2 R-HSA-5654738 6.535223e-01 0.185 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 6.549658e-01 0.184 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 6.585899e-01 0.181 0 0
Signaling by FGFR1 R-HSA-5654736 6.619302e-01 0.179 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 6.648696e-01 0.177 0 0
Toll-like Receptor Cascades R-HSA-168898 6.652937e-01 0.177 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 6.657696e-01 0.177 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 6.657696e-01 0.177 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.658363e-01 0.177 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.658363e-01 0.177 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 6.658363e-01 0.177 0 0
EPHB-mediated forward signaling R-HSA-3928662 6.696849e-01 0.174 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 6.810527e-01 0.167 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 6.810736e-01 0.167 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 6.810736e-01 0.167 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 6.810736e-01 0.167 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 6.810736e-01 0.167 0 0
Signal attenuation R-HSA-74749 6.810736e-01 0.167 0 0
CASP4 inflammasome assembly R-HSA-9948001 6.810736e-01 0.167 0 0
Maturation of spike protein R-HSA-9683686 6.810736e-01 0.167 0 0
Resolution of D-Loop Structures R-HSA-5693537 6.822411e-01 0.166 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 6.822411e-01 0.166 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 6.822411e-01 0.166 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 6.839660e-01 0.165 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 6.839660e-01 0.165 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 6.839660e-01 0.165 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.857869e-01 0.164 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 6.978069e-01 0.156 0 0
Regulation of beta-cell development R-HSA-186712 7.001371e-01 0.155 0 0
FGFR2 alternative splicing R-HSA-6803529 7.047484e-01 0.152 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.047484e-01 0.152 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 7.047484e-01 0.152 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 7.079238e-01 0.150 0 0
Signaling by APC mutants R-HSA-4839744 7.079238e-01 0.150 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 7.079238e-01 0.150 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 7.079238e-01 0.150 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 7.079238e-01 0.150 0 0
Ionotropic activity of kainate receptors R-HSA-451306 7.079238e-01 0.150 0 0
Chylomicron assembly R-HSA-8963888 7.079238e-01 0.150 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 7.079238e-01 0.150 0 0
Inorganic anion exchange by SLC26 transporters R-HSA-427601 7.079238e-01 0.150 0 0
RUNX2 regulates genes involved in cell migration R-HSA-8941332 7.079238e-01 0.150 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 7.079238e-01 0.150 0 0
Interleukin-2 signaling R-HSA-9020558 7.079238e-01 0.150 0 0
Dissolution of Fibrin Clot R-HSA-75205 7.079238e-01 0.150 0 0
Neddylation R-HSA-8951664 7.131300e-01 0.147 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 7.133507e-01 0.147 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 7.147194e-01 0.146 0 0
Gene Silencing by RNA R-HSA-211000 7.171292e-01 0.144 0 0
Interleukin-20 family signaling R-HSA-8854691 7.227461e-01 0.141 0 0
Formation of the ureteric bud R-HSA-9830674 7.227461e-01 0.141 0 0
ABC transporters in lipid homeostasis R-HSA-1369062 7.227461e-01 0.141 0 0
Viral Messenger RNA Synthesis R-HSA-168325 7.238885e-01 0.140 0 0
GPER1 signaling R-HSA-9634597 7.241677e-01 0.140 0 0
Metal ion SLC transporters R-HSA-425410 7.241677e-01 0.140 0 0
PRC2 methylates histones and DNA R-HSA-212300 7.279990e-01 0.138 0 0
G1/S-Specific Transcription R-HSA-69205 7.279990e-01 0.138 0 0
DS-GAG biosynthesis R-HSA-2022923 7.325150e-01 0.135 0 0
PI3K events in ERBB4 signaling R-HSA-1250342 7.325150e-01 0.135 0 0
Signaling by GSK3beta mutants R-HSA-5339716 7.325150e-01 0.135 0 0
Signaling by AMER1 mutants R-HSA-4839748 7.325150e-01 0.135 0 0
Signaling by AXIN mutants R-HSA-4839735 7.325150e-01 0.135 0 0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis R-HSA-9623433 7.325150e-01 0.135 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 7.325150e-01 0.135 0 0
Sodium/Calcium exchangers R-HSA-425561 7.325150e-01 0.135 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 7.352460e-01 0.134 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 7.358742e-01 0.133 0 0
Chemokine receptors bind chemokines R-HSA-380108 7.366905e-01 0.133 0 0
Pyruvate metabolism R-HSA-70268 7.376945e-01 0.132 0 0
Complex III assembly R-HSA-9865881 7.398077e-01 0.131 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 7.398077e-01 0.131 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.398077e-01 0.131 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.420533e-01 0.130 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.420533e-01 0.130 0 0
Cleavage of the damaged purine R-HSA-110331 7.420533e-01 0.130 0 0
MET activates RAS signaling R-HSA-8851805 7.550370e-01 0.122 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 7.550370e-01 0.122 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 7.550370e-01 0.122 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 7.550370e-01 0.122 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 7.550370e-01 0.122 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 7.550370e-01 0.122 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 7.550370e-01 0.122 0 0
GRB2 events in EGFR signaling R-HSA-179812 7.550370e-01 0.122 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 7.550370e-01 0.122 0 0
Regulation of IFNG signaling R-HSA-877312 7.550370e-01 0.122 0 0
Interleukin-15 signaling R-HSA-8983432 7.550370e-01 0.122 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 7.550370e-01 0.122 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 7.550370e-01 0.122 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 7.550370e-01 0.122 0 0
Signaling by LTK R-HSA-9842663 7.550370e-01 0.122 0 0
MET promotes cell motility R-HSA-8875878 7.555233e-01 0.122 0 0
Depurination R-HSA-73927 7.555233e-01 0.122 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 7.559633e-01 0.121 0 0
Laminin interactions R-HSA-3000157 7.559633e-01 0.121 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 7.559633e-01 0.121 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 7.559633e-01 0.121 0 0
Formation of the nephric duct R-HSA-9830364 7.559633e-01 0.121 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 7.684202e-01 0.114 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 7.712444e-01 0.113 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 7.716717e-01 0.113 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 7.739882e-01 0.111 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 7.756639e-01 0.110 0 0
Microbial factors inhibit CASP4 activity R-HSA-9956593 7.756639e-01 0.110 0 0
Formation of axial mesoderm R-HSA-9796292 7.756639e-01 0.110 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 7.756639e-01 0.110 0 0
Frs2-mediated activation R-HSA-170968 7.756639e-01 0.110 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.756639e-01 0.110 0 0
rRNA modification in the mitochondrion R-HSA-6793080 7.756639e-01 0.110 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 7.756639e-01 0.110 0 0
Maturation of nucleoprotein R-HSA-9683610 7.756639e-01 0.110 0 0
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759 7.756639e-01 0.110 0 0
Generation of second messenger molecules R-HSA-202433 7.807563e-01 0.107 0 0
Extracellular matrix organization R-HSA-1474244 7.823229e-01 0.107 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 7.856837e-01 0.105 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.856837e-01 0.105 0 0
Signaling by NTRKs R-HSA-166520 7.876976e-01 0.104 0 0
Maturation of spike protein R-HSA-9694548 7.925451e-01 0.101 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 7.925451e-01 0.101 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 7.928919e-01 0.101 0 0
Gastrulation R-HSA-9758941 7.941151e-01 0.100 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 7.945551e-01 0.100 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 7.945551e-01 0.100 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 7.945551e-01 0.100 0 0
Hydrolysis of LPC R-HSA-1483115 7.945551e-01 0.100 0 0
Signaling by FGFR4 in disease R-HSA-5655291 7.945551e-01 0.100 0 0
Malate-aspartate shuttle R-HSA-9856872 7.945551e-01 0.100 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 7.945551e-01 0.100 0 0
Regulation of KIT signaling R-HSA-1433559 7.945551e-01 0.100 0 0
HDL assembly R-HSA-8963896 7.945551e-01 0.100 0 0
Acyl chain remodeling of CL R-HSA-1482798 7.945551e-01 0.100 0 0
Zinc transporters R-HSA-435354 7.945551e-01 0.100 0 0
Interferon alpha/beta signaling R-HSA-909733 7.975286e-01 0.098 0 0
Activation of HOX genes during differentiation R-HSA-5619507 7.976545e-01 0.098 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 7.976545e-01 0.098 0 0
RSV-host interactions R-HSA-9833110 7.976545e-01 0.098 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.993145e-01 0.097 0 0
Pyroptosis R-HSA-5620971 7.993145e-01 0.097 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.993145e-01 0.097 0 0
Mitochondrial protein degradation R-HSA-9837999 8.064436e-01 0.093 0 0
HCMV Infection R-HSA-9609646 8.072500e-01 0.093 0 0
Cytoprotection by HMOX1 R-HSA-9707564 8.092065e-01 0.092 0 0
Asparagine N-linked glycosylation R-HSA-446203 8.097283e-01 0.092 0 0
Rab regulation of trafficking R-HSA-9007101 8.113676e-01 0.091 0 0
Mitochondrial biogenesis R-HSA-1592230 8.113676e-01 0.091 0 0
Erythropoietin activates RAS R-HSA-9027284 8.118565e-01 0.091 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 8.118565e-01 0.091 0 0
SHC1 events in EGFR signaling R-HSA-180336 8.118565e-01 0.091 0 0
Protein lipoylation R-HSA-9857492 8.118565e-01 0.091 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 8.118565e-01 0.091 0 0
DCC mediated attractive signaling R-HSA-418885 8.118565e-01 0.091 0 0
Telomere C-strand synthesis initiation R-HSA-174430 8.118565e-01 0.091 0 0
Biotin transport and metabolism R-HSA-196780 8.118565e-01 0.091 0 0
Transport and metabolism of PAPS R-HSA-174362 8.118565e-01 0.091 0 0
Signaling by Erythropoietin R-HSA-9006335 8.121707e-01 0.090 0 0
DNA methylation R-HSA-5334118 8.121707e-01 0.090 0 0
Regulation of gene expression in beta cells R-HSA-210745 8.121707e-01 0.090 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 8.125258e-01 0.090 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.145384e-01 0.089 0 0
Immune System R-HSA-168256 8.175962e-01 0.087 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 8.177955e-01 0.087 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 8.182807e-01 0.087 0 0
ECM proteoglycans R-HSA-3000178 8.223155e-01 0.085 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.242860e-01 0.084 0 0
TBC/RABGAPs R-HSA-8854214 8.247732e-01 0.084 0 0
Defective pyroptosis R-HSA-9710421 8.247732e-01 0.084 0 0
Entry of Influenza Virion into Host Cell via Endocytosis R-HSA-168275 8.277018e-01 0.082 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 8.277018e-01 0.082 0 0
Activation of SMO R-HSA-5635838 8.277018e-01 0.082 1 1
Fructose catabolism R-HSA-70350 8.277018e-01 0.082 0 0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) R-HSA-9942503 8.277018e-01 0.082 0 0
Differentiation of T cells R-HSA-9945266 8.277018e-01 0.082 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 8.277018e-01 0.082 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 8.277018e-01 0.082 0 0
Attachment and Entry R-HSA-9678110 8.277018e-01 0.082 0 0
Atorvastatin ADME R-HSA-9754706 8.277018e-01 0.082 0 0
Virus Assembly and Release R-HSA-168268 8.277018e-01 0.082 0 0
Adipogenesis R-HSA-9843745 8.298618e-01 0.081 0 0
Cardiac conduction R-HSA-5576891 8.298618e-01 0.081 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 8.303838e-01 0.081 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 8.322237e-01 0.080 0 0
Proteasome assembly R-HSA-9907900 8.345211e-01 0.079 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.356939e-01 0.078 0 0
Cargo concentration in the ER R-HSA-5694530 8.356939e-01 0.078 0 0
FCERI mediated NF-kB activation R-HSA-2871837 8.407148e-01 0.075 0 0
Signaling by FGFR R-HSA-190236 8.418297e-01 0.075 0 0
Neuronal System R-HSA-112316 8.421327e-01 0.075 0 0
G beta:gamma signalling through CDC42 R-HSA-8964616 8.422135e-01 0.075 0 0
Glycine degradation R-HSA-6783984 8.422135e-01 0.075 0 0
Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-4420332 8.422135e-01 0.075 0 0
Defective B4GALT7 causes EDS, progeroid type R-HSA-3560783 8.422135e-01 0.075 0 0
Fibronectin matrix formation R-HSA-1566977 8.422135e-01 0.075 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 8.422135e-01 0.075 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 8.422135e-01 0.075 0 0
Synthesis of PG R-HSA-1483148 8.422135e-01 0.075 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 8.422135e-01 0.075 0 0
Coenzyme A biosynthesis R-HSA-196783 8.422135e-01 0.075 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.437982e-01 0.074 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 8.437982e-01 0.074 0 0
Somitogenesis R-HSA-9824272 8.437982e-01 0.074 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 8.464276e-01 0.072 0 0
tRNA Aminoacylation R-HSA-379724 8.471452e-01 0.072 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.526207e-01 0.069 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.526207e-01 0.069 0 0
Formation of paraxial mesoderm R-HSA-9793380 8.549115e-01 0.068 0 0
Defective B3GAT3 causes JDSSDHD R-HSA-3560801 8.555038e-01 0.068 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 8.555038e-01 0.068 0 0
Uptake and function of anthrax toxins R-HSA-5210891 8.555038e-01 0.068 0 0
G-protein beta:gamma signalling R-HSA-397795 8.565197e-01 0.067 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 8.565197e-01 0.067 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 8.565197e-01 0.067 0 0
Signaling by PDGF R-HSA-186797 8.623397e-01 0.064 0 0
Acyl chain remodelling of PC R-HSA-1482788 8.660022e-01 0.062 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 8.660022e-01 0.062 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 8.676753e-01 0.062 0 0
Cytosolic iron-sulfur cluster assembly R-HSA-2564830 8.676753e-01 0.062 0 0
Tie2 Signaling R-HSA-210993 8.676753e-01 0.062 0 0
Interleukin-10 signaling R-HSA-6783783 8.727131e-01 0.059 0 0
G alpha (12/13) signalling events R-HSA-416482 8.727131e-01 0.059 0 0
Selenoamino acid metabolism R-HSA-2408522 8.740510e-01 0.058 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 8.749061e-01 0.058 0 0
eNOS activation R-HSA-203615 8.749061e-01 0.058 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.749061e-01 0.058 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.749061e-01 0.058 0 0
PI-3K cascade:FGFR3 R-HSA-5654710 8.788223e-01 0.056 0 0
Germ layer formation at gastrulation R-HSA-9754189 8.788223e-01 0.056 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 8.788223e-01 0.056 0 0
mRNA decay by 3' to 5' exoribonuclease R-HSA-429958 8.788223e-01 0.056 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 8.788223e-01 0.056 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 8.788223e-01 0.056 0 0
Specification of the neural plate border R-HSA-9834899 8.788223e-01 0.056 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 8.788223e-01 0.056 0 0
Transferrin endocytosis and recycling R-HSA-917977 8.832615e-01 0.054 0 0
Acyl chain remodelling of PE R-HSA-1482839 8.832615e-01 0.054 0 0
Signalling to ERKs R-HSA-187687 8.832615e-01 0.054 0 0
Signaling by FGFR2 in disease R-HSA-5655253 8.836925e-01 0.054 0 0
PI-3K cascade:FGFR4 R-HSA-5654720 8.890308e-01 0.051 0 0
Co-inhibition by CTLA4 R-HSA-389513 8.890308e-01 0.051 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 8.890308e-01 0.051 0 0
Signaling by NODAL R-HSA-1181150 8.890308e-01 0.051 0 0
Creatine metabolism R-HSA-71288 8.890308e-01 0.051 0 0
Acyl chain remodelling of PI R-HSA-1482922 8.890308e-01 0.051 0 0
Common Pathway of Fibrin Clot Formation R-HSA-140875 8.890308e-01 0.051 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 8.890308e-01 0.051 0 0
RUNX2 regulates bone development R-HSA-8941326 8.910976e-01 0.050 0 0
GPVI-mediated activation cascade R-HSA-114604 8.910976e-01 0.050 0 0
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877 8.910976e-01 0.050 0 0
FGFR2 mutant receptor activation R-HSA-1839126 8.910976e-01 0.050 0 0
G-protein activation R-HSA-202040 8.983799e-01 0.047 0 0
Matriglycan biosynthesis on DAG1 R-HSA-9939291 8.983799e-01 0.047 0 0
Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 8.983799e-01 0.047 0 0
Regulation of MITF-M-dependent genes involved in apoptosis R-HSA-9824594 8.983799e-01 0.047 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 8.983799e-01 0.047 0 0
Acyl chain remodelling of PG R-HSA-1482925 8.983799e-01 0.047 0 0
Platelet activation, signaling and aggregation R-HSA-76002 8.998346e-01 0.046 0 0
Amino acids regulate mTORC1 R-HSA-9639288 9.030169e-01 0.044 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 9.053237e-01 0.043 0 0
CS-GAG biosynthesis R-HSA-2022870 9.069418e-01 0.042 0 0
Ribavirin ADME R-HSA-9755088 9.069418e-01 0.042 0 0
Serine metabolism R-HSA-977347 9.069418e-01 0.042 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 9.069418e-01 0.042 0 0
Mitochondrial calcium ion transport R-HSA-8949215 9.069418e-01 0.042 0 0
Attachment and Entry R-HSA-9694614 9.069418e-01 0.042 0 0
Metabolism of proteins R-HSA-392499 9.108803e-01 0.041 0 0
Pentose phosphate pathway R-HSA-71336 9.117667e-01 0.040 0 0
PI-3K cascade:FGFR1 R-HSA-5654689 9.147829e-01 0.039 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 9.147829e-01 0.039 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 9.147829e-01 0.039 0 0
Fructose metabolism R-HSA-5652084 9.147829e-01 0.039 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 9.151629e-01 0.039 0 0
Infectious disease R-HSA-5663205 9.170149e-01 0.038 0 0
Hemostasis R-HSA-109582 9.175444e-01 0.037 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 9.177967e-01 0.037 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 9.202854e-01 0.036 0 0
G beta:gamma signalling through PI3Kgamma R-HSA-392451 9.219636e-01 0.035 0 0
Interleukin receptor SHC signaling R-HSA-912526 9.219636e-01 0.035 0 0
Mitochondrial mRNA modification R-HSA-9937008 9.219636e-01 0.035 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.234375e-01 0.035 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 9.237714e-01 0.034 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 9.237714e-01 0.034 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 9.237714e-01 0.034 0 0
Ca2+ pathway R-HSA-4086398 9.246684e-01 0.034 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 9.285397e-01 0.032 0 0
Mitochondrial RNA degradation R-HSA-9836573 9.285397e-01 0.032 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 9.285397e-01 0.032 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 9.287118e-01 0.032 0 0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9615017 9.287118e-01 0.032 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.288625e-01 0.032 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.324823e-01 0.030 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 9.332040e-01 0.030 0 0
PI-3K cascade:FGFR2 R-HSA-5654695 9.345620e-01 0.029 0 0
Tight junction interactions R-HSA-420029 9.345620e-01 0.029 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 9.345620e-01 0.029 0 0
Hyaluronan degradation R-HSA-2160916 9.345620e-01 0.029 0 0
Neurotransmitter release cycle R-HSA-112310 9.345790e-01 0.029 0 0
Metabolism of polyamines R-HSA-351202 9.373000e-01 0.028 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 9.400771e-01 0.027 0 0
Regulation of RUNX1 Expression and Activity R-HSA-8934593 9.400771e-01 0.027 0 0
Sphingolipid catabolism R-HSA-9845614 9.400771e-01 0.027 0 0
Abacavir ADME R-HSA-2161522 9.400771e-01 0.027 0 0
Diseases of branched-chain amino acid catabolism R-HSA-9865118 9.400771e-01 0.027 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.411628e-01 0.026 0 0
Aquaporin-mediated transport R-HSA-445717 9.411628e-01 0.026 0 0
Amine ligand-binding receptors R-HSA-375280 9.425476e-01 0.026 0 0
Mitochondrial protein import R-HSA-1268020 9.448040e-01 0.025 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.448040e-01 0.025 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 9.451276e-01 0.025 0 0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 9.451276e-01 0.025 0 0
Signaling by FGFR3 in disease R-HSA-5655332 9.451276e-01 0.025 0 0
Triglyceride biosynthesis R-HSA-75109 9.451276e-01 0.025 0 0
Insulin processing R-HSA-264876 9.451276e-01 0.025 0 0
Synthesis of PE R-HSA-1483213 9.451276e-01 0.025 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 9.451276e-01 0.025 0 0
Maturation of hRSV A proteins R-HSA-9828806 9.451276e-01 0.025 0 0
Platelet homeostasis R-HSA-418346 9.462617e-01 0.024 0 0
Diseases associated with glycosaminoglycan metabolism R-HSA-3560782 9.465625e-01 0.024 0 0
Interferon gamma signaling R-HSA-877300 9.471315e-01 0.024 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 9.482349e-01 0.023 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 9.497528e-01 0.022 0 0
Insulin receptor recycling R-HSA-77387 9.497528e-01 0.022 0 0
Prednisone ADME R-HSA-9757110 9.497528e-01 0.022 0 0
Pyrimidine salvage R-HSA-73614 9.497528e-01 0.022 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 9.500563e-01 0.022 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 9.503091e-01 0.022 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.512269e-01 0.022 0 0
IGF1R signaling cascade R-HSA-2428924 9.514662e-01 0.022 0 0
Stimuli-sensing channels R-HSA-2672351 9.515020e-01 0.022 0 0
Ion channel transport R-HSA-983712 9.525897e-01 0.021 0 0
Synthesis of PC R-HSA-1483191 9.538041e-01 0.021 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 9.539884e-01 0.020 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 9.539884e-01 0.020 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.545085e-01 0.020 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.576658e-01 0.019 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 9.578671e-01 0.019 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 9.578671e-01 0.019 0 0
Neurotransmitter clearance R-HSA-112311 9.578671e-01 0.019 0 0
DAP12 signaling R-HSA-2424491 9.578671e-01 0.019 0 0
Kidney development R-HSA-9830369 9.600653e-01 0.018 0 0
Regulation of insulin secretion R-HSA-422356 9.621332e-01 0.017 0 0
PI3K Cascade R-HSA-109704 9.629328e-01 0.016 0 0
Signaling by WNT in cancer R-HSA-4791275 9.646719e-01 0.016 0 0
DAG1 glycosylations R-HSA-8931838 9.646719e-01 0.016 0 0
The phototransduction cascade R-HSA-2514856 9.655706e-01 0.015 0 0
Recycling of bile acids and salts R-HSA-159418 9.676505e-01 0.014 0 0
tRNA processing R-HSA-72306 9.687757e-01 0.014 0 0
Metabolism of cofactors R-HSA-8978934 9.693199e-01 0.014 0 0
CS/DS degradation R-HSA-2024101 9.703782e-01 0.013 0 0
Miscellaneous transport and binding events R-HSA-5223345 9.703782e-01 0.013 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 9.703782e-01 0.013 0 0
Heme degradation R-HSA-189483 9.703782e-01 0.013 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 9.704376e-01 0.013 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 9.728761e-01 0.012 0 0
Hyaluronan metabolism R-HSA-2142845 9.728761e-01 0.012 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 9.728761e-01 0.012 0 0
Signal amplification R-HSA-392518 9.728761e-01 0.012 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 9.751634e-01 0.011 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 9.751634e-01 0.011 0 0
Defects in vitamin and cofactor metabolism R-HSA-3296482 9.751634e-01 0.011 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 9.762685e-01 0.010 0 0
Glycosphingolipid transport R-HSA-9845576 9.772580e-01 0.010 0 0
Triglyceride catabolism R-HSA-163560 9.772580e-01 0.010 0 0
IRS-mediated signalling R-HSA-112399 9.779829e-01 0.010 0 0
Synthesis of PA R-HSA-1483166 9.779829e-01 0.010 0 0
Ubiquinol biosynthesis R-HSA-2142789 9.791761e-01 0.009 0 0
Collagen chain trimerization R-HSA-8948216 9.791761e-01 0.009 0 0
Metabolism of folate and pterines R-HSA-196757 9.791761e-01 0.009 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.795771e-01 0.009 0 0
Parasitic Infection Pathways R-HSA-9824443 9.804407e-01 0.009 0 0
Leishmania infection R-HSA-9658195 9.804407e-01 0.009 0 0
Integration of energy metabolism R-HSA-163685 9.805144e-01 0.009 0 0
Purine salvage R-HSA-74217 9.809325e-01 0.008 0 0
Collagen formation R-HSA-1474290 9.810296e-01 0.008 0 0
Triglyceride metabolism R-HSA-8979227 9.810591e-01 0.008 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.820935e-01 0.008 0 0
rRNA processing in the mitochondrion R-HSA-8868766 9.840136e-01 0.007 0 0
Inositol phosphate metabolism R-HSA-1483249 9.840892e-01 0.007 0 0
Leishmania phagocytosis R-HSA-9664417 9.842594e-01 0.007 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 9.842594e-01 0.007 0 0
Parasite infection R-HSA-9664407 9.842594e-01 0.007 0 0
NCAM signaling for neurite out-growth R-HSA-375165 9.849056e-01 0.007 0 0
Peptide ligand-binding receptors R-HSA-375276 9.852045e-01 0.006 0 0
Scavenging by Class A Receptors R-HSA-3000480 9.865971e-01 0.006 0 0
Insulin receptor signalling cascade R-HSA-74751 9.870357e-01 0.006 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 9.887634e-01 0.005 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.888718e-01 0.005 0 0
Degradation of the extracellular matrix R-HSA-1474228 9.895564e-01 0.005 0 0
Netrin-1 signaling R-HSA-373752 9.897115e-01 0.004 0 0
Methylation R-HSA-156581 9.897115e-01 0.004 0 0
DAP12 interactions R-HSA-2172127 9.897115e-01 0.004 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 9.904533e-01 0.004 0 0
SLC transporter disorders R-HSA-5619102 9.917040e-01 0.004 0 0
COPII-mediated vesicle transport R-HSA-204005 9.918145e-01 0.004 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.918145e-01 0.004 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.927691e-01 0.003 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.927770e-01 0.003 0 0
Glyoxylate metabolism and glycine degradation R-HSA-389661 9.933795e-01 0.003 0 0
Aspirin ADME R-HSA-9749641 9.935076e-01 0.003 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.936340e-01 0.003 0 0
Signaling by Insulin receptor R-HSA-74752 9.936928e-01 0.003 0 0
Azathioprine ADME R-HSA-9748787 9.939383e-01 0.003 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 9.941246e-01 0.003 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 9.943703e-01 0.002 0 0
Complex IV assembly R-HSA-9864848 9.944500e-01 0.002 0 0
Branched-chain amino acid catabolism R-HSA-70895 9.944500e-01 0.002 0 0
Cytosolic sulfonation of small molecules R-HSA-156584 9.944500e-01 0.002 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.952414e-01 0.002 0 0
Nuclear Receptor transcription pathway R-HSA-383280 9.955982e-01 0.002 0 0
SLC-mediated transport of organic anions R-HSA-9955298 9.955982e-01 0.002 0 0
Disease R-HSA-1643685 9.958812e-01 0.002 0 0
Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1793185 9.961000e-01 0.002 0 0
Paracetamol ADME R-HSA-9753281 9.961000e-01 0.002 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.968120e-01 0.001 0 0
PI Metabolism R-HSA-1483255 9.971324e-01 0.001 0 0
Mitochondrial ribosome-associated quality control R-HSA-9937383 9.973329e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.976181e-01 0.001 0 0
PPARA activates gene expression R-HSA-1989781 9.976647e-01 0.001 0 0
Nucleotide salvage R-HSA-8956321 9.977031e-01 0.001 0 0
Collagen degradation R-HSA-1442490 9.977031e-01 0.001 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 9.978280e-01 0.001 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.979372e-01 0.001 0 0
Innate Immune System R-HSA-168249 9.981130e-01 0.001 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.985133e-01 0.001 0 0
Nicotinate metabolism R-HSA-196807 9.986475e-01 0.001 0 0
Sphingolipid metabolism R-HSA-428157 9.988506e-01 0.000 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.990499e-01 0.000 0 0
Metabolism of porphyrins R-HSA-189445 9.990499e-01 0.000 0 0
Purine catabolism R-HSA-74259 9.991302e-01 0.000 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.991629e-01 0.000 0 0
Mitochondrial translation elongation R-HSA-5389840 9.991629e-01 0.000 0 0
G alpha (s) signalling events R-HSA-418555 9.992004e-01 0.000 1 1
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.992710e-01 0.000 0 0
ROS and RNS production in phagocytes R-HSA-1222556 9.992710e-01 0.000 0 0
Mitochondrial translation initiation R-HSA-5368286 9.992867e-01 0.000 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.992968e-01 0.000 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.992968e-01 0.000 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.993327e-01 0.000 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.993417e-01 0.000 0 0
Phospholipid metabolism R-HSA-1483257 9.993777e-01 0.000 0 0
HCMV Late Events R-HSA-9610379 9.993858e-01 0.000 0 0
G alpha (i) signalling events R-HSA-418594 9.994490e-01 0.000 1 0
Peroxisomal lipid metabolism R-HSA-390918 9.996987e-01 0.000 0 0
Mitochondrial translation termination R-HSA-5419276 9.997286e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.997539e-01 0.000 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.997872e-01 0.000 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 9.998582e-01 0.000 0 0
Mitochondrial translation R-HSA-5368287 9.998757e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.998857e-01 0.000 0 0
FCGR activation R-HSA-2029481 9.998861e-01 0.000 0 0
Formation of the cornified envelope R-HSA-6809371 9.999320e-01 0.000 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.999508e-01 0.000 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.999544e-01 0.000 0 0
Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 9.999639e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.999709e-01 0.000 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.999886e-01 0.000 0 0
Peptide hormone metabolism R-HSA-2980736 9.999904e-01 0.000 0 0
Metabolism of nucleotides R-HSA-15869 9.999907e-01 0.000 0 0
Visual phototransduction R-HSA-2187338 9.999927e-01 0.000 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.999944e-01 0.000 0 0
Regulation of Complement cascade R-HSA-977606 9.999953e-01 0.000 0 0
Nucleotide catabolism R-HSA-8956319 9.999970e-01 0.000 0 0
Diseases of glycosylation R-HSA-3781865 9.999971e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999975e-01 0.000 0 0
Sensory perception of taste R-HSA-9717189 9.999977e-01 0.000 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.999980e-01 0.000 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.999986e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999987e-01 0.000 0 0
G alpha (q) signalling events R-HSA-416476 9.999987e-01 0.000 1 1
O-linked glycosylation R-HSA-5173105 9.999988e-01 0.000 0 0
Complement cascade R-HSA-166658 9.999994e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.999994e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.999995e-01 0.000 0 0
GPCR downstream signalling R-HSA-388396 9.999996e-01 0.000 1 0
Arachidonate metabolism R-HSA-2142753 9.999997e-01 0.000 0 0
Keratinization R-HSA-6805567 1.000000e+00 0.000 0 0
Metabolism of steroids R-HSA-8957322 1.000000e+00 0.000 0 0
Signaling by GPCR R-HSA-372790 1.000000e+00 0.000 1 0
Diseases of metabolism R-HSA-5668914 1.000000e+00 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 1.000000e+00 0.000 0 0
Infection with Enterobacteria R-HSA-9640148 1.000000e+00 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 1.000000e+00 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
GPCR ligand binding R-HSA-500792 1.000000e+00 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 1.000000e+00 0.000 0 0
Fatty acid metabolism R-HSA-8978868 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 -0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 -0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways