NEK4

Normalized values from positional scanning peptide array
Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA
Position-wise Probabilities
Log-Odds: Probabilities / STY Background
Sites with acceptor types representing >8% and count ≥10 are included
S Sites Probabilities
T Sites Probabilities
Log-Odds: S Sites / S Background
Log-Odds: T Sites / T Background
Sites with acceptor types representing >8% and count ≥10 are included
Download Data Table
Motif clusters with count ≥ 10 are shown
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substrate_uniprot site source substrate_genes site_seq
A0A2R8Y4L2 S95 Sugiyama HNRNPA1L3 HNRNPA1P48 RPHKVDGRVVEPKRAVSREDsQRPDAHLTVKKIFVGGIKED
A1L429 S7 Sugiyama GAGE12B; GAGE12C; GAGE12D; GAGE12E ______________MSWRGRsTyyWPRPRRYVQPPEMIGPM
A5A3E0 S1068 Sugiyama POTEF A26C1B SLSTFQQMWISKQEyDEsGPsIVHRKCL_____________
A5A3E0 S939 Sugiyama POTEF A26C1B VALDFEQEMATVAsSSSLEKsyELPDGQVItIGNERFRCPE
A5A3E0 T949 Sugiyama POTEF A26C1B TVAsSSSLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
A6NDE8 S7 Sugiyama GAGE12H ______________MSWRGRsTyyWPRPRRYVQPPEMIGPM
A6NER3 S7 Sugiyama GAGE12J ______________MSWRGRsTyyWPRPRPYVQPPEMIGPM
A6NMY6 S161 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B QEINRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAE
A6NMY6 S164 Sugiyama ANXA2P2 ANX2L2 ANX2P2 LPC2B NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGS
B2RPK0 S15 Sugiyama HMGB1P1 HMG1L1 HMGB1L1 ______MGKGDPKKPRGKMssyAFFVQtCREEHKKKHSDAS
B2RPK0 T22 Sugiyama HMGB1P1 HMG1L1 HMGB1L1 GKGDPKKPRGKMssyAFFVQtCREEHKKKHSDASVNFSEFS
O00267 T709 Sugiyama SUPT5H SPT5 SPT5H GGSGGMSRGRGRRDNELIGQtVRISQGPYKGYIGVVKDATE
O00273 T300 Sugiyama DFFA DFF1 DFF45 H13 KKTETVQEACERELALRLQQtQsLHsLRsIsAsKAsPPGDL
O14556 T301 Sugiyama GAPDHS GAPD2 GAPDH2 GAPDS HSD-35 HSD35 ASTGAAKAVTKVIPELKGKLtGMAFRVPTPDVSVVDLTCRL
O14950 T128 Sugiyama MYL12B MRLC2 MYLC2B ACFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPI
O14950 T129 Sugiyama MYL12B MRLC2 MYLC2B CFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPID
O14950 T160 Sugiyama MYL12B MRLC2 MYLC2B DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
O15212 T107 Sugiyama PFDN6 HKE2 PFD6 IKRYESQLRDLERQsEQQREtLAQLQQEFQRAQAAKAGAPG
O15347 S14 Sugiyama HMGB3 HMG2A HMG4 _______MAKGDPKKPKGKMsAYAFFVQtCREEHKKKNPEV
O15347 T22 Sugiyama HMGB3 HMG2A HMG4 AKGDPKKPKGKMsAYAFFVQtCREEHKKKNPEVPVNFAEFS
O15371 T46 Sugiyama EIF3D EIF3S7 RDMPyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGG
O15371 T49 Sugiyama EIF3D EIF3S7 PyQPFsKGDRLGKVADWtGAtyQDKRYTNKYSSQFGGGSQY
O43242 T69 Sugiyama PSMD3 GEADGKtAAAAAEHsQRELDtVtLEDIKEHVKQLEKAVSGK
O43242 T71 Sugiyama PSMD3 ADGKtAAAAAEHsQRELDtVtLEDIKEHVKQLEKAVSGKEP
O43290 T430 Sugiyama SART1 RKKEKEVVVRADDLLPLGDQtQDGDFGsRLRGRGRRRVsEV
O43390 T134 Sugiyama HNRNPR HNRPR KVQESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O43390 T137 Sugiyama HNRNPR HNRPR ESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O43390 T141 Sugiyama HNRNPR HNRPR GPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYSGVQP
O43390 Y136 Sugiyama HNRNPR HNRPR QESTKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O43399 T173 Sugiyama TPD52L2 RKLGDMRNsAtFKsFEDRVGtIKSKVVGDRENGsDNLPssA
O43423 T101 Sugiyama ANP32CP PP32R1 EKCPNLTHLYLSGNKIKDLstIEPLKQLENLKSLDLFNCEV
O43615 T198 Sugiyama TIMM44 MIMT44 TIM44 ALsQGVEsVKKEIDDsVLGQtGPyRRPQRLRKRTEFAGDKF
O43707 T359 Sugiyama ACTN4 RRVHKPPKVQEKCQLEINFNtLQtKLRLSNRPAFMPSEGKM
O43707 T362 Sugiyama ACTN4 HKPPKVQEKCQLEINFNtLQtKLRLSNRPAFMPSEGKMVSD
O43707 T443 Sugiyama ACTN4 sIHEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDL
O43707 T445 Sugiyama ACTN4 HEAWtDGKEAMLKHRDyEtAtLsDIKALIRKHEAFEsDLAA
O43852 T196 Sugiyama CALU FtAFLHPEEyDyMKDIVVQEtMEDIDKNADGFIDLEEyIGD
O43852 T89 Sugiyama CALU sKERLGKIVSKIDGDKDGFVtVDELKDWIKFAQKRWIyEDV
O60234 T114 Sugiyama GMFG VGCKPEQQMMyAGSKNRLVQtAELtKVFEIRTTDDLTEAWL
O60234 T118 Sugiyama GMFG PEQQMMyAGSKNRLVQtAELtKVFEIRTTDDLTEAWLQEKL
O60361 T79 Sugiyama NME2P1 VAMVWEGLNVVKTGRVMLGEtNPADsKPGtIRGDFCIQVGR
O60361 T88 Sugiyama NME2P1 VVKTGRVMLGEtNPADsKPGtIRGDFCIQVGRNIIHGsDsV
O60506 T131 Sugiyama SYNCRIP HNRPQ NSAP1 KVADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDS
O60506 T134 Sugiyama SYNCRIP HNRPQ NSAP1 DSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYS
O60506 T138 Sugiyama SYNCRIP HNRPQ NSAP1 GPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVYSGQQP
O60506 Y133 Sugiyama SYNCRIP HNRPQ NSAP1 ADSSKGPDEAKIKALLERtGytLDVttGQRKYGGPPPDSVY
O60841 S196 Sugiyama EIF5B IF2 KIAA0741 ERsRINssGEsGDEsDEFLQsRKGQKKNQKNKPGPNIEsGN
O60841 T289 Sugiyama EIF5B IF2 KIAA0741 QKESQRKFEEETVKSKVTVDtGVIPAsEEKAEtPtAAEDDN
O75347 S60 Sugiyama TBCA MRAEDGENyDIKKQAEILQEsRMMIPDCQRRLEAAyLDLQR
O75534 T761 Sugiyama CSDE1 D1S155E KIAA0885 NRU UNR GPKAVAAPRPDRLVNRLKNItLDDAsAPRLMVLRQPRGPDN
O75683 S13 Sugiyama SURF6 SURF-6 ________MASLLAKDAyLQsLAKKICSHsAPEQQARTRAG
O75821 S189 Sugiyama EIF3G EIF3S4 CPYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNK
O75821 T190 Sugiyama EIF3G EIF3S4 PYKDtLGPMQKELAEQLGLstGEKEKLPGELEPVQAtQNKt
O75914 T119 Sugiyama PAK3 OPHN3 QMCPGKLPEGIPEQWARLLQtsNItKLEQKKNPQAVLDVLK
O76087 S7 Sugiyama GAGE7 GAGE12I GAGE7B ______________MSWRGRsTyyWPRPRRYVQPPEMIGPM
O76094 S524 Sugiyama SRP72 KHLPSSDSMSLKVDVEALENsAGAtyIRKKGGKVTGDsQPK
O76094 T528 Sugiyama SRP72 SSDSMSLKVDVEALENsAGAtyIRKKGGKVTGDsQPKEQGQ
O94992 T270 Sugiyama HEXIM1 CLP1 EDG1 HIS1 MAQ1 GGsDGMGGDGSEFLQRDFsEtyERyHTEsLQNMsKQELIKE
O95071 T119 Sugiyama UBR5 EDD EDD1 HYD KIAA0896 GRTSRPGRTSDsPWFLsGSEtLGRLAGNTLGSRWSsGVGGs
O95218 T50 Sugiyama ZRANB2 ZIS ZNF265 SCNRCGREKTTEAKMMKAGGtEIGKtLAEKSRGLFsANDWQ
O95218 T55 Sugiyama ZRANB2 ZIS ZNF265 GREKTTEAKMMKAGGtEIGKtLAEKSRGLFsANDWQCKTCs
O95373 T968 Sugiyama IPO7 RANBP7 IIDDEDNPVDEYQIFKAIFQtIQNRNPVWyQALTHGLNEEQ
O95373 T997 Sugiyama IPO7 RANBP7 yQALTHGLNEEQRKQLQDIAtLADQRRAAHESKMIEKHGGY
O95626 T105 Sugiyama ANP32D PP32R2 EKCPNLIHLNLSGNKIKDLstIEPLKKLENLESLDLFTCEV
O95816 S31 Sugiyama BAG2 NEGRFCRsssMADRsSRLLEsLDQLELRVEALREAATAVEQ
P00338 S161 Sugiyama LDHA PIG19 DILTYVAWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVH
P00338 S167 Sugiyama LDHA PIG19 AWKISGFPKNRVIGsGCNLDsARFRyLMGERLGVHPLSCHG
P00558 S393 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GGDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDA
P00558 S399 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 CCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDALsNI__
P00558 T168 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 EAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNLPQKAGGF
P00558 T369 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 ARGTKALMDEVVKAtsRGCItIIGGGDtAtCCAKWNtEDKV
P00558 T376 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 MDEVVKAtsRGCItIIGGGDtAtCCAKWNtEDKVsHVstGG
P00558 T394 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 GDtAtCCAKWNtEDKVsHVstGGGAsLELLEGKVLPGVDAL
P00558 Y161 Sugiyama PGK1 PGKA MIG10 OK/SW-cl.110 KAEPAKIEAFRAsLSKLGDVyVNDAFGtAHRAHssMVGVNL
P00966 T208 Sugiyama ASS1 ASS IsyEAGILENPKNQAPPGLytKtQDPAKAPNtPDILEIEFK
P00966 T210 Sugiyama ASS1 ASS yEAGILENPKNQAPPGLytKtQDPAKAPNtPDILEIEFKKG
P02786 T143 Sugiyama TFRC yWDDLKRKLsEKLDstDFTGtIKLLNENsyVPREAGsQKDE
P04075 S336 Sugiyama ALDOA ALDA GKKENLKAAQEEYVKRALANsLACQGKytPsGQAGAAAsEs
P04075 S356 Sugiyama ALDOA ALDA sLACQGKytPsGQAGAAAsEsLFVsNHAy____________
P04075 S36 Sugiyama ALDOA ALDA LsDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENR
P04075 S360 Sugiyama ALDOA ALDA QGKytPsGQAGAAAsEsLFVsNHAy________________
P04075 T119 Sugiyama ALDOA ALDA KsKGGVVGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYK
P04075 T123 Sugiyama ALDOA ALDA GVVGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYKKDGA
P04075 T125 Sugiyama ALDOA ALDA VGIKVDKGVVPLAGtNGEtttQGLDGLsERCAQYKKDGADF
P04075 T37 Sugiyama ALDOA ALDA sDIAHRIVAPGKGILAADEstGsIAKRLQsIGtENtEENRR
P04075 T49 Sugiyama ALDOA ALDA GILAADEstGsIAKRLQsIGtENtEENRRFyRQLLLtADDR
P04075 T65 Sugiyama ALDOA ALDA QsIGtENtEENRRFyRQLLLtADDRVNPCIGGVILFHETLY
P04083 S173 Sugiyama ANXA1 ANX1 LPC1 NRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDFG
P04083 T169 Sugiyama ANXA1 ANX1 LPC1 IRDINRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRs
P04083 T172 Sugiyama ANXA1 ANX1 LPC1 INRVYREELKRDLAKDItsDtsGDFRNALLsLAKGDRsEDF
P04083 T223 Sugiyama ANXA1 ANX1 LPC1 ARALyEAGERRKGtDVNVFNtILttRSyPQLRRVFQKYTKY
P04083 T226 Sugiyama ANXA1 ANX1 LPC1 LyEAGERRKGtDVNVFNtILttRSyPQLRRVFQKYTKYSKH
P04406 S151 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 FVMGVNHEKYDNSLKIIsNAsCttNCLAPLAKVIHDNFGIV
P04406 S210 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GPsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtG
P04406 T104 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 KIKWGDAGAEyVVEstGVFttMEKAGAHLQGGAKRVIIsAP
P04406 T154 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GVNHEKYDNSLKIIsNAsCttNCLAPLAKVIHDNFGIVEGL
P04406 T211 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 PsGKLWRDGRGALQNIIPAstGAAKAVGKVIPELNGKLtGM
P04406 T229 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 AstGAAKAVGKVIPELNGKLtGMAFRVPtANVsVVDLtCRL
P04406 T246 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GKLtGMAFRVPtANVsVVDLtCRLEKPAKyDDIKKVVKQAS
P04406 T99 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 ERDPsKIKWGDAGAEyVVEstGVFttMEKAGAHLQGGAKRV
P04406 Y320 Sugiyama GAPDH GAPD CDABP0047 OK/SW-cl.12 GIALNDHFVKLIsWyDNEFGysNRVVDLMAHMAsKE_____
P04792 S82 Sugiyama HSPB1 HSP27 HSP28 AIEsPAVAAPAYsRALsRQLssGVsEIRHtADRWRVsLDVN
P05787 S291 Sugiyama KRT8 CYK8 ANRsRAEAEsMyQIKyEELQsLAGKHGDDLRRTKTEISEMN
P06733 S268 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 ASEFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyP
P06733 S27 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 HAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEAL
P06733 T100 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 KKLNVtEQEKIDKLMIEMDGtENKsKFGANAILGVsLAVCK
P06733 T19 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 __MSILKIHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGA
P06733 T205 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 GAEVyHNLKNVIKEKyGKDAtNVGDEGGFAPNILENKEGLE
P06733 T26 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 IHAREIFDsRGNPtVEVDLFtsKGLFRAAVPsGAstGIyEA
P06733 T41 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EVDLFtsKGLFRAAVPsGAstGIyEALELRDNDKtRYMGKG
P06733 T55 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 VPsGAstGIyEALELRDNDKtRYMGKGVSKAVEHINKtIAP
P06733 Y270 Sugiyama ENO1 ENO1L1 MBPB1 MPB1 EFFRsGKyDLDFKsPDDPsRyIsPDQLADLyKsFIKDyPVV
P07195 S162 Sugiyama LDHB DILTYVTWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIH
P07195 S168 Sugiyama LDHB TWKLSGLPKHRVIGsGCNLDsARFRyLMAEKLGIHPSSCHG
P07195 S303 Sugiyama LDHB GIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsADt
P07195 S320 Sugiyama LDHB GLtsVINQKLKDDEVAQLKKsADtLWDIQKDLKDL______
P07195 T302 Sugiyama LDHB YGIENEVFLSLPCILNARGLtsVINQKLKDDEVAQLKKsAD
P07195 T323 Sugiyama LDHB sVINQKLKDDEVAQLKKsADtLWDIQKDLKDL_________
P07205 S393 Sugiyama PGK2 PGKB GGDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEA
P07205 S399 Sugiyama PGK2 PGKB CCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEALSNM__
P07205 T168 Sugiyama PGK2 PGKB EAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNLPHKASGF
P07205 T394 Sugiyama PGK2 PGKB GDTATCCAKWNtEDKVsHVstGGGAsLELLEGKILPGVEAL
P07205 Y161 Sugiyama PGK2 PGKB KAEPDKIEAFRAsLSKLGDVyVNDAFGtAHRAHSSMVGVNL
P07237 T428 Sugiyama P4HB ERBA2L PDI PDIA1 PO4DB DKLGEtyKDHENIVIAKMDstANEVEAVKVHsFPtLKFFPA
P07355 S161 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D QEINRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAE
P07355 S164 Sugiyama ANXA2 ANX2 ANX2L4 CAL1H LPC2D NRVyKEMYKtDLEKDIIsDtsGDFRKLMVALAKGRRAEDGs
P07437 S115 Sugiyama TUBB TUBB5 OK/SW-cl.56 sGAGNNWAKGHytEGAELVDsVLDVVRKEAESCDCLQGFQL
P07437 T107 Sugiyama TUBB TUBB5 OK/SW-cl.56 PDNFVFGQsGAGNNWAKGHytEGAELVDsVLDVVRKEAESC
P07814 S335 Sugiyama EPRS1 EPRS GLNS PARS QARS QPRS PIG32 PIEKNLQMWEEMKKGsQFGQsCCLRAKIDMSSNNGCMRDPt
P07858 T95 Sugiyama CTSB CPSB TEDLKLPAsFDAREQWPQCPtIKEIRDQGSCGSCWAFGAVE
P07864 S161 Sugiyama LDHC LDH3 LDHX DILTYIVWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVH
P07864 S167 Sugiyama LDHC LDH3 LDHX VWKISGLPVTRVIGsGCNLDsARFRYLIGEKLGVHPTSCHG
P07900 S399 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKK
P07900 S406 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA RGVVDsEDLPLNIsREMLQQsKILKVIRKNLVKKCLELFtE
P07900 S476 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA RKKLsELLRyytsAsGDEMVsLKDYCTRMKENQKHIyyItG
P07900 S543 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA EPIDEyCVQQLKEFEGKtLVsVTKEGLELPEDEEEKKKQEE
P07900 S641 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DNstMGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKD
P07900 T195 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA DTGEPMGRGTKVILHLKEDQtEyLEERRIKEIVKKHSQFIG
P07900 T317 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA WtRNPDDItNEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P07900 T540 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA yMIEPIDEyCVQQLKEFEGKtLVsVTKEGLELPEDEEEKKK
P07900 T645 Sugiyama HSP90AA1 HSP90A HSPC1 HSPCA MGyMAAKKHLEINPDHsIIEtLRQKAEADKNDKSVKDLVIL
P08195 S598 Sugiyama SLC3A2 MDU1 LQASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEP
P08195 T401 Sugiyama SLC3A2 MDU1 NSSDLQQILSLLESNKDLLLtssyLsDsGstGEHtKSLVTQ
P08195 T415 Sugiyama SLC3A2 MDU1 NKDLLLtssyLsDsGstGEHtKSLVTQYLNATGNRWCSWSL
P08195 T599 Sugiyama SLC3A2 MDU1 QASDLPASASLPAKADLLLstQPGREEGsPLELERLKLEPH
P08238 S391 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB PEYLNFIRGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKK
P08238 S398 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RGVVDsEDLPLNIsREMLQQsKILKVIRKNIVKKCLELFsE
P08238 S45 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MSLIINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKL
P08238 S462 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB HEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKs
P08238 S468 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB RRRLsELLRyHtsQsGDEMtsLsEyVsRMKEtQKsIyyItG
P08238 S48 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IINTFYSNKEIFLRELIsNAsDALDKIRyEsLtDPsKLDsG
P08238 T190 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
P08238 T309 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB WtRNPDDItQEEyGEFyKsLtNDWEDHLAVKHFSVEGQLEF
P08238 T637 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB MGyMMAKKHLEINPDHPIVEtLRQKAEADKNDKAVKDLVVL
P08238 Y457 Sugiyama HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB LKLGIHEDstNRRRLsELLRyHtsQsGDEMtsLsEyVsRMK
P08758 S44 Sugiyama ANXA5 ANX5 ENX2 PP4 LRKAMKGLGtDEEsILtLLtsRsNAQRQEISAAFKTLFGRD
P08758 T40 Sugiyama ANXA5 ANX5 ENX2 PP4 DAEtLRKAMKGLGtDEEsILtLLtsRsNAQRQEISAAFKTL
P08758 T8 Sugiyama ANXA5 ANX5 ENX2 PP4 _____________MAQVLRGtVtDFPGFDERADAEtLRKAM
P09382 S63 Sugiyama LGALS1 CLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVFPFQPG
P09382 T58 Sugiyama LGALS1 DsNNLCLHFNPRFNAHGDANtIVCNsKDGGAWGTEQREAVF
P09429 S15 Sugiyama HMGB1 HMG1 ______MGKGDPKKPRGKMssyAFFVQtCREEHKKKHPDAs
P09429 T22 Sugiyama HMGB1 HMG1 GKGDPKKPRGKMssyAFFVQtCREEHKKKHPDAsVNFsEFs
P09651 S95 Sugiyama HNRNPA1 HNRPA1 RPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
P09661 S226 Sugiyama SNRPA1 NAIANAstLAEVERLKGLLQsGQIPGRERRsGPtDDGEEEM
P0CG38 S1068 Sugiyama POTEI SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CG39 S1031 Sugiyama POTEJ SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
P0CL80 S7 Sugiyama GAGE12F ______________MSWRGRsTyyWPRPRRYVQPPEMIGPM
P0DPH7 T334 Sugiyama TUBA3C TUBA2 ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
P0DPH7 T337 Sugiyama TUBA3C TUBA2 MLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVGINy
P0DPH7 T51 Sugiyama TUBA3C TUBA2 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P0DPH7 T56 Sugiyama TUBA3C TUBA2 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
P0DPH7 T73 Sugiyama TUBA3C TUBA2 FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
P0DPH7 T80 Sugiyama TUBA3C TUBA2 KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAA
P0DPH7 T82 Sugiyama TUBA3C TUBA2 VPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAANN
P0DPH7 Y83 Sugiyama TUBA3C TUBA2 PRAVFVDLEPtVVDEVRtGtyRQLFHPEQLItGKEDAANNy
P0DSO3 S7 Sugiyama GAGE4 ______________MSWRGRsTyyWPRPRRYVQPPEMIGPM
P10412 S55 Sugiyama H1-4 H1F4 HIST1H1E AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P10412 T45 Sugiyama H1-4 H1F4 HIST1H1E RKsAGAAKRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P10412 T92 Sugiyama H1-4 H1F4 HIST1H1E DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P10412 T96 Sugiyama H1-4 H1F4 HIST1H1E NNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAAsGEA
P10412 T99 Sugiyama H1-4 H1F4 HIST1H1E RIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAAsGEAKPK
P10412 Y71 Sugiyama H1-4 H1F4 HIST1H1E SKERsGVsLAALKKALAAAGyDVEKNNSRIKLGLKsLVsKG
P10809 S488 Sugiyama HSPD1 HSP60 IKRTLKIPAMtIAKNAGVEGsLIVEKIMQSSsEVGYDAMAG
P10809 T231 Sugiyama HSPD1 HSP60 LEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAyVLLsEKKI
P10809 Y223 Sugiyama HSPD1 HSP60 DGKtLNDELEIIEGMKFDRGyIsPyFINtsKGQKCEFQDAy
P11142 T163 Sugiyama HSPA8 HSC70 HSP73 HSPA10 VVtVPAyFNDsQRQAtKDAGtIAGLNVLRIINEPtAAAIAy
P11142 T226 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVNHFIAEFK
P11142 T37 Sugiyama HSPA8 HSC70 HSP73 HSPA10 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P11142 T47 Sugiyama HSPA8 HSC70 HSP73 HSPA10 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPtNtV
P11142 T64 Sugiyama HSPA8 HSC70 HSP73 HSPA10 FtDtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQ
P11142 T66 Sugiyama HSPA8 HSC70 HSP73 HSPA10 DtERLIGDAAKNQVAMNPtNtVFDAKRLIGRRFDDAVVQsD
P11586 T128 Sugiyama MTHFD1 MTHFC MTHFD SINTEEVINAIAPEKDVDGLtsINAGKLARGDLNDCFIPCt
P11940 T191 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 GRFKSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLF
P11940 Y194 Sugiyama PABPC1 PAB1 PABP PABP1 PABPC2 KSRKEREAELGARAKEFtNVyIKNFGEDMDDERLKDLFGKF
P12004 S172 Sugiyama PCNA sHIGDAVVIsCAKDGVKFSAsGELGNGNIKLSQTSNVDKEE
P12814 T340 Sugiyama ACTN1 RRLHKPPKVQEKCQLEINFNtLQtKLRLsNRPAFMPsEGRM
P12814 T343 Sugiyama ACTN1 HKPPKVQEKCQLEINFNtLQtKLRLsNRPAFMPsEGRMVSD
P13639 S593 Sugiyama EEF2 EF2 SDPVVsyREtVsEEsNVLCLsKsPNKHNRLyMKARPFPDGL
P13639 S732 Sugiyama EEF2 EF2 DAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCP
P13639 T735 Sugiyama EEF2 EF2 HRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQCPEQV
P13639 Y730 Sugiyama EEF2 EF2 HADAIHRGGGQIIPtARRCLyAsVLtAQPRLMEPIyLVEIQ
P13667 S379 Sugiyama PDIA4 ERP70 ERP72 QPEKFQSKYEPRSHMMDVQGstQDsAIKDFVLKyALPLVGH
P13861 S99 Sugiyama PRKAR2A PKR2 PRKAR2 EsEEDEDLEVPVPsRFNRRVsVCAEtyNPDEEEEDTDPRVI
P14314 T115 Sugiyama PRKCSH G19P1 GVCDCCDGtDEyNsGVICENtCKEKGRKEREsLQQMAEVtR
P14314 T134 Sugiyama PRKCSH G19P1 NtCKEKGRKEREsLQQMAEVtREGFRLKKILIEDWKKAREE
P14314 T469 Sugiyama PRKCSH G19P1 WGsWIGPDHDKFSAMKyEQGtGCWQGPNRstTVRLLCGKEt
P14618 S202 Sugiyama PKM OIP3 PK2 PK3 PKM2 SLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAAVDLPAVs
P14618 T195 Sugiyama PKM OIP3 PK2 PK3 PKM2 yVDDGLISLQVKQKGADFLVtEVENGGsLGsKKGVNLPGAA
P14618 T45 Sugiyama PKM OIP3 PK2 PK3 PKM2 TFLEHMCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMI
P14618 T50 Sugiyama PKM OIP3 PK2 PK3 PKM2 MCRLDIDsPPItARNtGIICtIGPAsRsVEtLKEMIKsGMN
P14625 S106 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 MKLIINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENAL
P14625 S109 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 IINSLYKNKEIFLRELIsNAsDALDKIRLISLTDENALSGN
P14625 S64 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 tDDEVVQREEEAIQLDGLNAsQIRELREKSEKFAFQAEVNR
P14625 T171 Sugiyama HSP90B1 GRP94 HSPC4 TRA1 GVGMtREELVKNLGTIAKsGtsEFLNKMTEAQEDGQSTSEL
P15311 S535 Sugiyama EZR VIL2 EKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDIIHN
P15311 T533 Sugiyama EZR VIL2 NEEKRITEAEKNERVQRQLLtLssELsQARDENKRTHNDII
P15531 T103 Sugiyama NME1 NDPKA NM23 VVKTGRVMLGEtNPADsKPGtIRGDFCIQVGRNIIHGsDsV
P15531 T94 Sugiyama NME1 NDPKA NM23 VAMVWEGLNVVKTGRVMLGEtNPADsKPGtIRGDFCIQVGR
P16070 T76 Sugiyama CD44 LHR MDU2 MDU3 MIC4 FNSTLPTMAQMEKALsIGFEtCRyGFIEGHVVIPRIHPNSI
P16401 T102 Sugiyama H1-5 H1F5 HIST1H1B RIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAAsGEAKPK
P16401 T95 Sugiyama H1-5 H1F5 HIST1H1B DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16401 T99 Sugiyama H1-5 H1F5 HIST1H1B NNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAAsGEA
P16402 S56 Sugiyama H1-3 H1F3 HIST1H1D AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16402 T100 Sugiyama H1-3 H1F3 HIST1H1D RIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAASGEGKPK
P16402 T46 Sugiyama H1-3 H1F3 HIST1H1D KAGATAGKRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P16402 T93 Sugiyama H1-3 H1F3 HIST1H1D DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16402 T97 Sugiyama H1-3 H1F3 HIST1H1D NNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAASGEG
P16402 Y72 Sugiyama H1-3 H1F3 HIST1H1D SKERsGVsLAALKKALAAAGyDVEKNNSRIKLGLKsLVsKG
P16403 S55 Sugiyama H1-2 H1F2 HIST1H1C AsGPPVsELItKAVAASKERsGVsLAALKKALAAAGyDVEK
P16403 T45 Sugiyama H1-2 H1F2 HIST1H1C AKKAGGtPRKAsGPPVsELItKAVAASKERsGVsLAALKKA
P16403 T92 Sugiyama H1-2 H1F2 HIST1H1C DVEKNNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAA
P16403 T96 Sugiyama H1-2 H1F2 HIST1H1C NNSRIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAAsGEA
P16403 T99 Sugiyama H1-2 H1F2 HIST1H1C RIKLGLKsLVsKGtLVQtKGtGAsGsFKLNKKAAsGEAKPK
P16403 Y71 Sugiyama H1-2 H1F2 HIST1H1C SKERsGVsLAALKKALAAAGyDVEKNNSRIKLGLKsLVsKG
P17066 T228 Sugiyama HSPA6 HSP70B' DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P17066 T49 Sugiyama HSPA6 HSP70B' EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P18124 T17 Sugiyama RPL7 ____MEGVEEKKKEVPAVPEtLKKKRRNFAELKIKRLRKKF
P18206 S820 Sugiyama VCL DAKAVAGNIsDPGLQKsFLDsGyRILGAVAKVREAFQPQEP
P18615 S135 Sugiyama NELFE RD RDBP sADDDLQEsSRRPQRKsLyEsFVsssDRLRELGPDGEEAEG
P18621 S111 Sugiyama RPL17 LLHMLKNAESNAELKGLDVDsLVIEHIQVNKAPKMRRRTYR
P18621 T79 Sugiyama RPL17 PFRRYNGGVGRCAQAKQWGWtQGRWPKKSAEFLLHMLKNAE
P18669 S155 Sugiyama PGAM1 PGAMA CDABP0006 NIsKDRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQI
P18669 T146 Sugiyama PGAM1 PGAMA CDABP0006 MEPDHPFysNIsKDRRyADLtEDQLPsCEsLKDtIARALPF
P18669 T159 Sugiyama PGAM1 PGAMA CDABP0006 DRRyADLtEDQLPsCEsLKDtIARALPFWNEEIVPQIKEGK
P19105 T127 Sugiyama MYL12A MLCB MRLC3 RLC ACFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPI
P19105 T128 Sugiyama MYL12A MLCB MRLC3 RLC CFDEEATGTIQEDYLRELLttMGDRFtDEEVDELyREAPID
P19105 T159 Sugiyama MYL12A MLCB MRLC3 RLC DELyREAPIDKKGNFNyIEFtRILKHGAKDKDD________
P19338 S460 Sugiyama NCL ADAEKTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNST
P19338 T464 Sugiyama NCL KTFEEKQGtEIDGRsIsLyytGEKGQNQDYRGGKNSTWsGE
P20290 T131 Sugiyama BTF3 NACB OK/SW-cl.8 NQGTVIHFNNPKVQAsLAANtFtItGHAEtKQLTEMLPsIL
P20290 T133 Sugiyama BTF3 NACB OK/SW-cl.8 GTVIHFNNPKVQAsLAANtFtItGHAEtKQLTEMLPsILNQ
P20290 T135 Sugiyama BTF3 NACB OK/SW-cl.8 VIHFNNPKVQAsLAANtFtItGHAEtKQLTEMLPsILNQLG
P20290 T140 Sugiyama BTF3 NACB OK/SW-cl.8 NPKVQAsLAANtFtItGHAEtKQLTEMLPsILNQLGADsLt
P20618 S157 Sugiyama PSMB1 PSC5 IIGGLDEEGKGAVysFDPVGsyQRDsFKAGGSASAMLQPLL
P20674 T105 Sugiyama COX5A EPKIIDAALRACRRLNDFAstVRILEVVKDKAGPHKEIYPY
P22061 S133 Sugiyama PCMT1 KELVDDsVNNVRKDDPTLLssGRVQLVVGDGRMGYAEEAPY
P22392 T103 Sugiyama NME2 NM23B VVKTGRVMLGEtNPADsKPGtIRGDFCIQVGRNIIHGsDsV
P22392 T94 Sugiyama NME2 NM23B VAMVWEGLNVVKTGRVMLGEtNPADsKPGtIRGDFCIQVGR
P22492 Y75 Sugiyama H1-6 H1FT H1T HIST1H1T SQERVGMSLVALKKALAAAGyDVEKNNSRIKLSLKSLVNKG
P22626 S212 Sugiyama HNRNPA2B1 HNRPA2B1 EMQEVQssRsGRGGNFGFGDsRGGGGNFGPGPGsNFRGGsD
P23381 S358 Sugiyama WARS1 IFI53 WARS WRS TFFPALQGAQTKMsAsDPNssIFLtDtAKQIKTKVNKHAFs
P23381 T364 Sugiyama WARS1 IFI53 WARS WRS QGAQTKMsAsDPNssIFLtDtAKQIKTKVNKHAFsGGRDtI
P23396 S104 Sugiyama RPS3 OK/SW-cl.26 VELyAEKVAtRGLCAIAQAEsLRyKLLGGLAVRRACyGVLR
P23396 T242 Sugiyama RPS3 OK/SW-cl.26 PIsEQKGGKPEPPAMPQPVPtA___________________
P23396 T93 Sugiyama RPS3 OK/SW-cl.26 VQKRFGFPEGsVELyAEKVAtRGLCAIAQAEsLRyKLLGGL
P23528 T63 Sugiyama CFL1 CFL DKKNIILEEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyA
P23528 T70 Sugiyama CFL1 CFL EEGKEILVGDVGQtVDDPyAtFVKMLPDKDCRyALyDAtyE
P23588 S122 Sugiyama EIF4B NLPyDVTEESIKEFFRGLNIsAVRLPREPsNPERLKGFGyA
P23588 S207 Sugiyama EIF4B DRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYRDR
P23588 T205 Sugiyama EIF4B GRDRNRDsDKtDTDWRARPAtDsFDDyPPRRGDDsFGDKYR
P24534 S174 Sugiyama EEF1B2 EEF1B EF1B DMAKLEECVRsIQADGLVWGssKLVPVGyGIKKLQIQCVVE
P25788 S243 Sugiyama PSMA3 HC8 PSC8 GRHEIVPKDIREEAEKyAKEsLKEEDEsDDDNM________
P26038 S576 Sugiyama MSN YKtLRQIRQGNTKQRIDEFEsM___________________
P26373 S109 Sugiyama RPL13 BBC1 OK/SW-cl.46 KVARTIGIsVDPRRRNKstEsLQANVQRLKEYRSKLILFPR
P26373 S181 Sugiyama RPL13 BBC1 OK/SW-cl.46 YKKEKARVItEEEKNFKAFAsLRMARANARLFGIRAKRAKE
P26373 S77 Sugiyama RPL13 BBC1 OK/SW-cl.46 PIVRCPTVRYHTKVRAGRGFsLEELRVAGIHKKVARTIGIs
P26373 T148 Sugiyama RPL13 BBC1 OK/SW-cl.46 PRKPSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARV
P26373 T151 Sugiyama RPL13 BBC1 OK/SW-cl.46 PSAPKKGDssAEELKLAtQLtGPVMPVRNVYKKEKARVItE
P26447 T15 Sugiyama S100A4 CAPL MTS1 ______MACPLEKALDVMVstFHKYSGKEGDKFKLNKSELK
P26583 S15 Sugiyama HMGB2 HMG2 ______MGKGDPNKPRGKMssyAFFVQtCREEHKKKHPDss
P26583 T22 Sugiyama HMGB2 HMG2 GKGDPNKPRGKMssyAFFVQtCREEHKKKHPDssVNFAEFS
P26639 S522 Sugiyama TARS1 TARS PEKFLGDIEVWDQAEKQLENsLNEFGEKWELNsGDGAFyGP
P26641 T287 Sugiyama EEF1G EF1G PRO1608 EQALAAEPKAKDPFAHLPKstFVLDEFKRKysNEDtLsVAL
P27797 S52 Sugiyama CALR CRTC GWtsRWIEsKHKSDFGKFVLssGKFyGDEEKDKGLQTSQDA
P27797 T34 Sugiyama CALR CRTC LAVAEPAVYFKEQFLDGDGWtsRWIEsKHKSDFGKFVLssG
P29401 T444 Sugiyama TKT DGPSQMALEDLAMFRsVPtstVFyPsDGVAtEKAVELAANT
P29692 S64 Sugiyama EEF1D EF1D sVILRDIARARENIQKsLAGssGPGAssGtsGDHGELVVRI
P30041 T48 Sugiyama PRDX6 AOP2 KIAA0106 FLGDSWGILFSHPRDFtPVCttELGRAAKLAPEFAKRNVKL
P30050 T135 Sugiyama RPL12 QMRHRSLARELsGtIKEILGtAQsVGCNVDGRHPHDIIDDI
P30050 T18 Sugiyama RPL12 ___MPPKFDPNEIKVVYLRCtGGEVGAtsALAPKIGPLGLs
P30050 T25 Sugiyama RPL12 FDPNEIKVVYLRCtGGEVGAtsALAPKIGPLGLsPKKVGDD
P30086 S60 Sugiyama PEBP1 PBP PEBP VLtPtQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPK
P30086 T167 Sugiyama PEBP1 PBP PEBP GKFKVAsFRKKyELRAPVAGtCyQAEWDDyVPKLyEQLsGK
P30086 T65 Sugiyama PEBP1 PBP PEBP QVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREWH
P30086 Y64 Sugiyama PEBP1 PBP PEBP tQVKNRPtsIsWDGLDsGKLytLVLtDPDAPsRKDPKYREW
P30101 T485 Sugiyama PDIA3 ERP57 ERP60 GRP58 KKyEGGRELsDFIsyLQREAtNPPVIQEEKPKKKKKAQEDL
P30622 Y262 Sugiyama CLIP1 CYLN1 RSN CGVELDEPLGKNDGAVAGtRyFQCQPKyGLFAPVHKVTKIG
P31327 T326 Sugiyama CPS1 AKTYKMSMANRGQNQPVLNItNKQAFITAQNHGYALDNTLP
P31327 T45 Sugiyama CPS1 AHQKWKFSRPGIRLLSVKAQtAHIVLEDGtKMKGYSFGHPS
P31946 T231 Sugiyama YWHAB EsyKDstLIMQLLRDNLtLWtSENQGDEGDAGEGEN_____
P31947 T228 Sugiyama SFN HME1 LsEDsyKDstLIMQLLRDNLtLWTADNAGEEGGEAPQEPQs
P31948 S460 Sugiyama STIP1 AMKDytKAMDVYQKALDLDssCKEAADGYQRCMMAQyNRHD
P31949 T33 Sugiyama S100A11 MLN70 S100C CIESLIAVFQKYAGKDGyNytLsKtEFLsFMNTELAAFTKN
P33240 T333 Sugiyama CSTF2 ANVPtPRGLLGDAPNDPRGGtLLsVtGEVEPRGYLGPPHQG
P33240 T338 Sugiyama CSTF2 PRGLLGDAPNDPRGGtLLsVtGEVEPRGYLGPPHQGPPMHH
P34931 T228 Sugiyama HSPA1L DVSILTIDDGIFEVKAtAGDtHLGGEDFDNRLVsHFVEEFK
P34931 T39 Sugiyama HSPA1L CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P34931 T49 Sugiyama HSPA1L EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPQNTV
P35269 T154 Sugiyama GTF2F1 RAP74 AFEAFPVHNWYNFTPLARHRtLtAEEAEEEWERRNKVLNHF
P35579 S1195 Sugiyama MYH9 TLEEEAKTHEAQIQEMRQKHsQAVEELAEQLEQtKRVKANL
P35579 S1308 Sugiyama MYH9 LLsQsDSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLs
P35579 S1376 Sugiyama MYH9 EKQIATLHAQVADMKKKMEDsVGCLEtAEEVKRKLQKDLEG
P35579 S1714 Sugiyama MYH9 RAKRQAQQERDELADEIANssGKGALALEEKRRLEARIAQL
P35579 S1916 Sugiyama MYH9 LQRELEDAtEtADAMNREVssLKNKLRRGDLPFVVPRRMAR
P35579 S876 Sugiyama MYH9 KVREKQLAAENRLTEMEtLQsQLMAEKLQLQEQLQAETELC
P35579 T1005 Sugiyama MYH9 DQNCKLAKEKKLLEDRIAEFtTNLtEEEEKSKsLAKLKNKH
P35579 T1009 Sugiyama MYH9 KLAKEKKLLEDRIAEFtTNLtEEEEKSKsLAKLKNKHEAMI
P35579 T1151 Sugiyama MYH9 EKQKRDLGEELEALKtELEDtLDstAAQQELRSKREQEVNI
P35579 T1155 Sugiyama MYH9 RDLGEELEALKtELEDtLDstAAQQELRSKREQEVNILKKT
P35579 T1208 Sugiyama MYH9 QEMRQKHsQAVEELAEQLEQtKRVKANLEKAKQtLENERGE
P35579 T1313 Sugiyama MYH9 DSKSSKLTKDFsALEsQLQDtQELLQEENRQKLsLstKLKQ
P35579 T1382 Sugiyama MYH9 LHAQVADMKKKMEDsVGCLEtAEEVKRKLQKDLEGLSQRHE
P35579 T1745 Sugiyama MYH9 RRLEARIAQLEEELEEEQGNtELINDRLKKANLQIDQINtD
P35579 T1904 Sugiyama MYH9 EEAQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRG
P35579 T1906 Sugiyama MYH9 AQRANAsRRKLQRELEDAtEtADAMNREVssLKNKLRRGDL
P35579 T873 Sugiyama MYH9 ELVKVREKQLAAENRLTEMEtLQsQLMAEKLQLQEQLQAET
P35580 S1371 Sugiyama MYH10 QQEEEEEARKNLEKQVLALQsQLADtKKKVDDDLGTIESLE
P35580 T1320 Sugiyama MYH10 EKKGIKFAKDAAsLEsQLQDtQELLQEETRQKLNLSSRIRQ
P35580 T1376 Sugiyama MYH10 EEARKNLEKQVLALQsQLADtKKKVDDDLGTIESLEEAKKK
P35609 T347 Sugiyama ACTN2 RRKHKPPKVQEKCQLEINFNtLQtKLRISNRPAFMPSEGKM
P35609 T350 Sugiyama ACTN2 HKPPKVQEKCQLEINFNtLQtKLRISNRPAFMPSEGKMVSD
P36578 S87 Sugiyama RPL4 RPL1 WGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAPTKT
P36578 T62 Sugiyama RPL4 RPL1 TNLRKNNRQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGG
P36578 T69 Sugiyama RPL4 RPL1 RQPyAVsELAGHQtsAEsWGtGRAVARIPRVRGGGtHRsGQ
P36578 T84 Sugiyama RPL4 RPL1 AEsWGtGRAVARIPRVRGGGtHRsGQGAFGNMCRGGRMFAP
P37108 T45 Sugiyama SRP14 sVyItLKKYDGRTKPIPKKGtVEGFEPADNKCLLRATDGKK
P37802 S83 Sugiyama TAGLN2 KIAA0120 CDABP0035 CELINALYPEGQAPVKKIQAstMAFKQMEQIsQFLQAAERY
P37802 T180 Sugiyama TAGLN2 KIAA0120 CDABP0035 RNFsDNQLQEGKNVIGLQMGtNRGAsQAGMtGyGMPRQIL_
P37802 T190 Sugiyama TAGLN2 KIAA0120 CDABP0035 GKNVIGLQMGtNRGAsQAGMtGyGMPRQIL___________
P38646 T116 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 DGERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKD
P38646 T120 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 LVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIKNV
P38646 T398 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 SDIGEVILVGGMTRMPKVQQtVQDLFGRAPsKAVNPDEAVA
P38646 T86 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 CVAVMEGKQAKVLENAEGARttPsVVAFtADGERLVGMPAK
P38646 Y118 Sugiyama HSPA9 GRP75 HSPA9B mt-HSP70 ERLVGMPAKRQAVtNPNNtFyAtKRLIGRRYDDPEVQKDIK
P39019 T36 Sugiyama RPS19 RALAAFLKKSGKLKVPEWVDtVKLAKHKELAPyDENWFytR
P39019 Y54 Sugiyama RPS19 VDtVKLAKHKELAPyDENWFytRAAstARHLYLRGGAGVGs
P39023 S13 Sugiyama RPL3 OK/SW-cl.32 ________MSHRKFSAPRHGsLGFLPRKRSSRHRGKVKSFP
P39687 T105 Sugiyama ANP32A C15orf1 LANP MAPM PHAP1 EKCPNLTHLNLsGNKIKDLstIEPLKKLENLKsLDLFNCEV
P40429 T155 Sugiyama RPL13A FAYLGRLAHEVGWKyQAVtAtLEEKRKEKAKIHYRKKKQLM
P40855 S147 Sugiyama PEX19 HK33 PXF OK/SW-cl.22 SCLKETLSGLAKNATDLQNssMsEEELTKAMEGLGMDEGDG
P42766 T59 Sugiyama RPL35 GAASKLsKIRVVRKSIARVLtVINQtQKENLRKFYKGKKyK
P42766 T64 Sugiyama RPL35 LsKIRVVRKSIARVLtVINQtQKENLRKFYKGKKyKPLDLR
P46776 S68 Sugiyama RPL27A yHPGyFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRV
P46776 T72 Sugiyama RPL27A yFGKVGMKHYHLKRNQsFCPtVNLDKLWtLVsEQtRVNAAK
P46776 T80 Sugiyama RPL27A HYHLKRNQsFCPtVNLDKLWtLVsEQtRVNAAKNKtGAAPI
P46776 T86 Sugiyama RPL27A NQsFCPtVNLDKLWtLVsEQtRVNAAKNKtGAAPIIDVVRs
P46776 T95 Sugiyama RPL27A LDKLWtLVsEQtRVNAAKNKtGAAPIIDVVRsGyyKVLGKG
P46777 S224 Sugiyama RPL5 MSTP030 VADyMRyLMEEDEDAyKKQFsQyIKNsVtPDMMEEMyKKAH
P46777 T177 Sugiyama RPL5 MSTP030 NKVFGALKGAVDGGLsIPHstKRFPGyDsEsKEFNAEVHRK
P46778 T29 Sugiyama RPL21 RGTRYMFSRPFRKHGVVPLAtyMRIYKKGDIVDIKGMGTVQ
P46783 T148 Sugiyama RPS10 RRSAVPPGADKKAEAGAGsAtEFQFRGGFGRGRGQPPQ___
P48741 T228 Sugiyama HSPA7 HSP70B DVSVLSIDAGVFEVKAtAGDtHLGGEDFDNRLVNHFMEEFR
P48741 T49 Sugiyama HSPA7 HSP70B EILANDQGNRTtPsyVAFtDtERLVGDAAKsQAALNPHNtV
P49327 T1999 Sugiyama FASN FAS LLENQTPEFFQDVCKPKYsGtLNLDRVTREACPELDYFVVF
P49327 T2215 Sugiyama FASN FAS DEAsELACPtPKEDGLAQQQtQLNLRSLLVNPEGPtLMRLN
P49411 T433 Sugiyama TUFM LRQPMILEKGQRFTLRDGNRtIGTGLVTNTLAMTEEEKNIK
P50991 S51 Sugiyama CCT4 CCTD SRB AQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtIt
P50991 T50 Sugiyama CCT4 CCTD SRB PAQIRFsNISAAKAVADAIRtsLGPKGMDKMIQDGKGDVtI
P50991 T69 Sugiyama CCT4 CCTD SRB RtsLGPKGMDKMIQDGKGDVtItNDGAtILKQMQVLHPAAR
P50991 T76 Sugiyama CCT4 CCTD SRB GMDKMIQDGKGDVtItNDGAtILKQMQVLHPAARMLVELSK
P51149 T168 Sugiyama RAB7A RAB7 NIPyFEtSAKEAINVEQAFQtIARNALKQETEVELyNEFPE
P51957 S16 Sugiyama NEK4 STK2 _____MPLAAYCYLRVVGKGsyGEVtLVKHRRDGKQYVIKK
P51957 S213 Sugiyama NEK4 STK2 GCCVYEMATLKHAFNAKDMNsLVYRIIEGKLPPMPRDYSPE
P51957 S377 Sugiyama NEK4 STK2 TELATISSVNIDILPAKGRDsVsDGFVQENQPRYLDASNEL
P51957 S379 Sugiyama NEK4 STK2 LATISSVNIDILPAKGRDsVsDGFVQENQPRYLDASNELGG
P51957 S402 Sugiyama NEK4 STK2 FVQENQPRYLDASNELGGICsIsQVEEEMLQDNTKSSAQPE
P51957 S404 Sugiyama NEK4 STK2 QENQPRYLDASNELGGICsIsQVEEEMLQDNTKSSAQPENL
P51957 S457 Sugiyama NEK4 STK2 KNEPVKPLQPLIKEQKPKDQsLALsPKLECsGtILAHsNLR
P51957 S461 Sugiyama NEK4 STK2 VKPLQPLIKEQKPKDQsLALsPKLECsGtILAHsNLRLLGs
P51957 S467 Sugiyama NEK4 STK2 LIKEQKPKDQsLALsPKLECsGtILAHsNLRLLGsSDsPAS
P51957 S474 Sugiyama NEK4 STK2 KDQsLALsPKLECsGtILAHsNLRLLGsSDsPASASRVAGI
P51957 S481 Sugiyama NEK4 STK2 sPKLECsGtILAHsNLRLLGsSDsPASASRVAGITGVCHHA
P51957 S484 Sugiyama NEK4 STK2 LECsGtILAHsNLRLLGsSDsPASASRVAGITGVCHHAQDQ
P51957 S526 Sugiyama NEK4 STK2 AGECIIEKQGRIHPDLQPHNsGSEPsLsRQRRQKRREQTEH
P51957 S531 Sugiyama NEK4 STK2 IEKQGRIHPDLQPHNsGSEPsLsRQRRQKRREQTEHRGEKR
P51957 S533 Sugiyama NEK4 STK2 KQGRIHPDLQPHNsGSEPsLsRQRRQKRREQTEHRGEKRQV
P51957 S563 Sugiyama NEK4 STK2 QTEHRGEKRQVRRDLFAFQEsPPRFLPSHPIVGKVDVTSTQ
P51957 S58 Sugiyama NEK4 STK2 NLRNASSRERRAAEQEAQLLsQLKHPNIVTYKESWEGGDGL
P51957 S624 Sugiyama NEK4 STK2 EMSSSKDRPLSARERRRLKQsQEEMSSsGPSVRKAsLsVAG
P51957 S631 Sugiyama NEK4 STK2 RPLSARERRRLKQsQEEMSSsGPSVRKAsLsVAGPGKPQEE
P51957 S639 Sugiyama NEK4 STK2 RRLKQsQEEMSSsGPSVRKAsLsVAGPGKPQEEDQPLPARR
P51957 S641 Sugiyama NEK4 STK2 LKQsQEEMSSsGPSVRKAsLsVAGPGKPQEEDQPLPARRLs
P51957 S661 Sugiyama NEK4 STK2 sVAGPGKPQEEDQPLPARRLssDCsVtQERKQIHCLsEDEL
P51957 S662 Sugiyama NEK4 STK2 VAGPGKPQEEDQPLPARRLssDCsVtQERKQIHCLsEDELS
P51957 S720 Sugiyama NEK4 STK2 GQTNEINALVQLMTQTLKLDsKEsCEDVPVANPVSEFKLHR
P51957 S723 Sugiyama NEK4 STK2 NEINALVQLMTQTLKLDsKEsCEDVPVANPVSEFKLHRKyR
P51957 S766 Sugiyama NEK4 STK2 LILHGKVAEEAEEIHFKELPsAIMPGsEKIRRLVEVLRtDV
P51957 S772 Sugiyama NEK4 STK2 VAEEAEEIHFKELPsAIMPGsEKIRRLVEVLRtDVIRGLGV
P51957 T21 Sugiyama NEK4 STK2 MPLAAYCYLRVVGKGsyGEVtLVKHRRDGKQYVIKKLNLRN
P51957 T469 Sugiyama NEK4 STK2 KEQKPKDQsLALsPKLECsGtILAHsNLRLLGsSDsPASAS
P51957 T745 Sugiyama NEK4 STK2 EDVPVANPVSEFKLHRKyRDtLILHGKVAEEAEEIHFKELP
P51957 T784 Sugiyama NEK4 STK2 LPsAIMPGsEKIRRLVEVLRtDVIRGLGVQLLEQVYDLLEE
P51957 Y17 Sugiyama NEK4 STK2 ____MPLAAYCYLRVVGKGsyGEVtLVKHRRDGKQYVIKKL
P51957 Y742 Sugiyama NEK4 STK2 EsCEDVPVANPVSEFKLHRKyRDtLILHGKVAEEAEEIHFK
P52565 S148 Sugiyama ARHGDIA GDIA1 YIQHTyRKGVKIDKtDyMVGsYGPRAEEyEFLtPVEEAPKG
P52565 T142 Sugiyama ARHGDIA GDIA1 IVSGMKYIQHTyRKGVKIDKtDyMVGsYGPRAEEyEFLtPV
P53634 T431 Sugiyama CTSC CPPI GYGTDSASGMDYWIVKNsWGtGWGENGyFRIRRGtDECAIE
P53999 S118 Sugiyama SUB1 PC4 RPO2TC1 PGRKGIsLNPEQWsQLKEQIsDIDDAVRKL___________
P54105 T34 Sugiyama CLNS1A CLCI ICLN EGLLRQQPDTEAVLNGKGLGtGtLyIAEsRLSWLDGsGLGF
P54105 T36 Sugiyama CLNS1A CLCI ICLN LLRQQPDTEAVLNGKGLGtGtLyIAEsRLSWLDGsGLGFSL
P54652 T229 Sugiyama HSPA2 DVSILTIEDGIFEVKstAGDtHLGGEDFDNRMVSHLAEEFK
P54652 T38 Sugiyama HSPA2 CVGVFQHGKVEIIANDQGNRttPsyVAFtDtERLIGDAAKN
P54652 T48 Sugiyama HSPA2 EIIANDQGNRttPsyVAFtDtERLIGDAAKNQVAMNPTNTI
P55010 T227 Sugiyama EIF5 ttEEAQRRRMDEISDHAKVLtLsDDLERtIEERVNILFDFV
P55010 T235 Sugiyama EIF5 RMDEISDHAKVLtLsDDLERtIEERVNILFDFVKKKKEEGV
P55209 T269 Sugiyama NAP1L1 NRP GPEIMGCTGCQIDWKKGKNVtLKtIKKKQKHKGRGTVRTVT
P55209 T272 Sugiyama NAP1L1 NRP IMGCTGCQIDWKKGKNVtLKtIKKKQKHKGRGTVRTVTKTV
P60174 S204 Sugiyama TPI1 TPI EVHEKLRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQ
P60174 T214 Sugiyama TPI1 TPI KsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGG
P60174 T217 Sugiyama TPI1 TPI VsDAVAQstRIIyGGsVtGAtCKELASQPDVDGFLVGGAsL
P60174 T28 Sugiyama TPI1 TPI FVGGNWKMNGRKQsLGELIGtLNAAKVPADtEVVCAPPtAy
P60174 T38 Sugiyama TPI1 TPI RKQsLGELIGtLNAAKVPADtEVVCAPPtAyIDFARQKLDP
P60174 T46 Sugiyama TPI1 TPI IGtLNAAKVPADtEVVCAPPtAyIDFARQKLDPKIAVAAQN
P60174 T90 Sugiyama TPI1 TPI VTNGAFtGEIsPGMIKDCGAtWVVLGHsERRHVFGEsDELI
P60174 Y209 Sugiyama TPI1 TPI LRGWLKsNVsDAVAQstRIIyGGsVtGAtCKELASQPDVDG
P60660 T103 Sugiyama MYL6 QGtyEDyVEGLRVFDKEGNGtVMGAEIRHVLVtLGEKMTEE
P60660 T22 Sugiyama MYL6 CDFTEDQTAEFKEAFQLFDRtGDGKILysQCGDVMRALGQN
P60709 S239 Sugiyama ACTB VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P60709 S300 Sugiyama ACTB NSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItAL
P60709 S323 Sugiyama ACTB ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P60709 S368 Sugiyama ACTB sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P60709 T106 Sugiyama ACTB WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P60709 T201 Sugiyama ACTB AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL
P60709 T203 Sugiyama ACTB RDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALDF
P60709 T229 Sugiyama ACTB VRDIKEKLCyVALDFEQEMAtAAssssLEKsyELPDGQVIt
P60709 T249 Sugiyama ACTB tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P60709 T303 Sugiyama ACTB MKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPs
P60709 T304 Sugiyama ACTB KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P60709 T318 Sugiyama ACTB VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P60709 T324 Sugiyama ACTB tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P60709 Y294 Sugiyama ACTB IHETTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQ
P60983 T114 Sugiyama GMFB VGCKPEQQMMYAGSKNKLVQtAELtKVFEIRNTEDLTEEWL
P60983 T118 Sugiyama GMFB PEQQMMYAGSKNKLVQtAELtKVFEIRNTEDLTEEWLREKL
P61247 S238 Sugiyama RPS3A FTE1 MFTL LKKPKFELGKLMELHGEGsssGKAtGDEtGAKVERADGyEP
P61254 T8 Sugiyama RPL26 _____________MKFNPFVtsDRsKNRKRHFNAPsHIRRK
P61313 S97 Sugiyama RPL15 EC45 TCBAP0781 KGAtyGKPVHHGVNQLKFARsLQsVAEERAGRHCGALRVLN
P61604 T45 Sugiyama HSPE1 TVTKGGIMLPEKSQGKVLQAtVVAVGsGsKGKGGEIQPVsV
P61769 T106 Sugiyama B2M CDABP0092 HDCMA22P YYTEFTPTEKDEYACRVNHVtLsQPKIVKWDRDM_______
P61978 S401 Sugiyama HNRNPK HNRPK GDLGGPIIttQVtIPKDLAGsIIGKGGQRIKQIRHEsGAsI
P61978 S75 Sugiyama HNRNPK HNRPK GAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISADIE
P61978 Y72 Sugiyama HNRNPK HNRPK KNAGAVIGKGGKNIKALRtDyNAsVsVPDssGPERILsISA
P61981 T31 Sugiyama YWHAG ARLAEQAERyDDMAAAMKNVtELNEPLsNEERNLLsVAyKN
P62241 S160 Sugiyama RPS8 OK/SW-cl.83 KRSKKIQKKYDERKKNAKIssLLEEQFQQGKLLACIASRPG
P62249 S9 Sugiyama RPS16 ____________MPsKGPLQsVQVFGRKKTATAVAHCKRGN
P62258 S148 Sugiyama YWHAE YHRyLAEFAtGNDRKEAAENsLVAyKAAsDIAMtELPPTHP
P62258 T229 Sugiyama YWHAE LsEEsyKDstLIMQLLRDNLtLWtsDMQGDGEEQNKEALQD
P62266 T34 Sugiyama RPS23 RSHRRDQKWHDKQYKKAHLGtALKANPFGGAsHAKGIVLEK
P62273 S9 Sugiyama RPS29 ____________MGHQQLyWsHPRKFGQGSRSCRVCSNRHG
P62277 S14 Sugiyama RPS13 _______MGRMHAPGKGLsQsALPyRRsVPtWLKLTsDDVK
P62280 T15 Sugiyama RPS11 ______MADIQTERAyQKQPtIFQNKKRVLLGEtGKEKLPR
P62280 T28 Sugiyama RPS11 RAyQKQPtIFQNKKRVLLGEtGKEKLPRYYKNIGLGFKtPK
P62280 T54 Sugiyama RPS11 PRYYKNIGLGFKtPKEAIEGtyIDKKCPFTGNVsIRGRILs
P62312 T75 Sugiyama LSM6 QLKNKyGDAFIRGNNVLyIstQKRRM_______________
P62314 S59 Sugiyama SNRPD1 HLKAVKMTLKNREPVQLEtLsIRGNNIRYFILPDsLPLDTL
P62314 T57 Sugiyama SNRPD1 NTHLKAVKMTLKNREPVQLEtLsIRGNNIRYFILPDsLPLD
P62424 T84 Sugiyama RPL7A SURF-3 SURF3 QRQRAILyKRLKVPPAINQFtQALDRQTAtQLLKLAHKYRP
P62736 S241 Sugiyama ACTA2 ACTSA ACTVS GIG46 VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P62736 S325 Sugiyama ACTA2 ACTSA ACTVS GIG46 tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P62736 T251 Sugiyama ACTA2 ACTSA ACTVS GIG46 tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P62736 T320 Sugiyama ACTA2 ACTSA ACTVS GIG46 VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P62736 T326 Sugiyama ACTA2 ACTSA ACTVS GIG46 TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P62753 S148 Sugiyama RPS6 OK/SW-cl.2 tVPRRLGPKRASRIRKLFNLsKEDDVRQyVVRKPLNKEGKK
P62826 T21 Sugiyama RAN ARA24 OK/SW-cl.81 MAAQGEPQVQFKLVLVGDGGtGKttFVKRHLtGEFEKKyVA
P62826 T32 Sugiyama RAN ARA24 OK/SW-cl.81 KLVLVGDGGtGKttFVKRHLtGEFEKKyVATLGVEVHPLVF
P62826 T66 Sugiyama RAN ARA24 OK/SW-cl.81 EVHPLVFHTNRGPIKFNVWDtAGQEKFGGLRDGYYIQAQCA
P62857 T21 Sugiyama RPS28 MDTSRVQPIKLARVTKVLGRtGsQGQCtQVRVEFMDDtsRs
P62857 T38 Sugiyama RPS28 LGRtGsQGQCtQVRVEFMDDtsRsIIRNVKGPVREGDVLtL
P62899 T22 Sugiyama RPL31 APAKKGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRA
P62899 T26 Sugiyama RPL31 KGGEKKKGRsAINEVVtREytINIHKRIHGVGFKKRAPRAL
P62906 S113 Sugiyama RPL10A NEDD6 LNKNKKLVKKLAKKyDAFLAsEsLIKQIPRILGPGLNKAGK
P62906 S115 Sugiyama RPL10A NEDD6 KNKKLVKKLAKKyDAFLAsEsLIKQIPRILGPGLNKAGKFP
P62906 T9 Sugiyama RPL10A NEDD6 ____________MSSKVsRDtLyEAVREVLHGNQRKRRKFL
P62917 S130 Sugiyama RPL8 GTIVCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKL
P62917 T135 Sugiyama RPL8 CLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSK
P62917 T143 Sugiyama RPL8 RGKLARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANR
P62917 T146 Sugiyama RPL8 LARAsGNyAtVIsHNPEtKKtRVKLPSGSKKVISSANRAVV
P62917 Y133 Sugiyama RPL8 VCCLEEKPGDRGKLARAsGNyAtVIsHNPEtKKtRVKLPSG
P62942 T22 Sugiyama FKBP1A FKBP1 FKBP12 GVQVEtIsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRD
P62942 T28 Sugiyama FKBP1A FKBP1 FKBP12 IsPGDGRtFPKRGQtCVVHytGMLEDGKKFDSSRDRNKPFK
P62942 T7 Sugiyama FKBP1A FKBP1 FKBP12 ______________MGVQVEtIsPGDGRtFPKRGQtCVVHy
P62979 S134 Sugiyama RPS27A UBA80 UBCEP1 IsRLRRECPsDECGAGVFMAsHFDRHyCGKCCLtyCFNKPE
P63104 S145 Sugiyama YWHAZ YYRyLAEVAAGDDKKGIVDQsQQAyQEAFEIsKKEMQPTHP
P63104 S156 Sugiyama YWHAZ DDKKGIVDQsQQAyQEAFEIsKKEMQPTHPIRLGLALNFSV
P63104 S28 Sugiyama YWHAZ QKAKLAEQAERyDDMAACMKsVtEQGAELsNEERNLLsVAy
P63104 T226 Sugiyama YWHAZ LsEEsyKDstLIMQLLRDNLtLWtsDtQGDEAEAGEGGEN_
P63165 S61 Sugiyama SUMO1 SMT3C SMT3H3 UBL1 OK/SW-cl.43 TTHLKKLKESYCQRQGVPMNsLRFLFEGQRIADNHtPKELG
P63167 T26 Sugiyama DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1 AVIKNADMsEEMQQDsVECAtQALEKYNIEKDIAAHIKKEF
P63173 T14 Sugiyama RPL38 _______MPRKIEEIKDFLLtARRKDAKSVKIKKNKDNVKF
P63261 S239 Sugiyama ACTG1 ACTG VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63261 S300 Sugiyama ACTG1 ACTG NSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItAL
P63261 S323 Sugiyama ACTG1 ACTG ttMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGG
P63261 S368 Sugiyama ACTG1 ACTG sLstFQQMWISKQEyDEsGPsIVHRKCF_____________
P63261 T106 Sugiyama ACTG1 ACTG WHHtFyNELRVAPEEHPVLLtEAPLNPKANREKMTQIMFET
P63261 T201 Sugiyama ACTG1 ACTG AGRDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVAL
P63261 T203 Sugiyama ACTG1 ACTG RDLTDyLMKILtERGysFtttAEREIVRDIKEKLCyVALDF
P63261 T229 Sugiyama ACTG1 ACTG VRDIKEKLCyVALDFEQEMAtAAssssLEKsyELPDGQVIt
P63261 T249 Sugiyama ACTG1 ACTG tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPsFLGM
P63261 T303 Sugiyama ACTG1 ACTG MKCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPs
P63261 T304 Sugiyama ACTG1 ACTG KCDVDIRKDLyANtVLsGGttMyPGIADRMQKEItALAPst
P63261 T318 Sugiyama ACTG1 ACTG VLsGGttMyPGIADRMQKEItALAPstMKIKIIAPPERKYs
P63261 T324 Sugiyama ACTG1 ACTG tMyPGIADRMQKEItALAPstMKIKIIAPPERKYsVWIGGs
P63261 Y294 Sugiyama ACTG1 ACTG IHETTFNSIMKCDVDIRKDLyANtVLsGGttMyPGIADRMQ
P63267 S240 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P63267 S324 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P63267 T250 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P63267 T319 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P63267 T325 Sugiyama ACTG2 ACTA3 ACTL3 ACTSG TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P67809 S102 Sugiyama YBX1 NSEP1 YB1 EDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEA
P67809 S136 Sugiyama YBX1 NSEP1 YB1 GEKGAEAANVtGPGGVPVQGsKYAADRNHYRRYPRRRGPPR
P67809 T108 Sugiyama YBX1 NSEP1 YB1 QtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKGAEAANVtGP
P67809 T126 Sugiyama YBX1 NSEP1 YB1 GEtVEFDVVEGEKGAEAANVtGPGGVPVQGsKYAADRNHYR
P67809 Y99 Sugiyama YBX1 NSEP1 YB1 DtKEDVFVHQtAIKKNNPRKyLRsVGDGEtVEFDVVEGEKG
P67936 T237 Sugiyama TPM4 IDDLEEKLAQAKEENVGLHQtLDQtLNELNCI_________
P67936 T241 Sugiyama TPM4 EEKLAQAKEENVGLHQtLDQtLNELNCI_____________
P68032 S241 Sugiyama ACTC1 ACTC VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68032 S325 Sugiyama ACTC1 ACTC tTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68032 T251 Sugiyama ACTC1 ACTC tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68032 T320 Sugiyama ACTC1 ACTC VLSGGtTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68032 T326 Sugiyama ACTC1 ACTC TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68104 T432 Sugiyama EEF1A1 EEF1A EF1A LENG7 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
P68133 S241 Sugiyama ACTA1 ACTA VALDFENEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
P68133 S325 Sugiyama ACTA1 ACTA TTMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGG
P68133 T251 Sugiyama ACTA1 ACTA tAAssssLEKsyELPDGQVItIGNERFRCPETLFQPSFIGM
P68133 T320 Sugiyama ACTA1 ACTA VMSGGTTMYPGIADRMQKEItALAPstMKIKIIAPPERKYS
P68133 T326 Sugiyama ACTA1 ACTA TMYPGIADRMQKEItALAPstMKIKIIAPPERKYSVWIGGS
P68363 T334 Sugiyama TUBA1B ACCLLyRGDVVPKDVNAAIAtIKtKRsIQFVDWCPTGFKVG
P68363 T337 Sugiyama TUBA1B LLyRGDVVPKDVNAAIAtIKtKRsIQFVDWCPTGFKVGINy
P68363 T51 Sugiyama TUBA1B QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
P68363 T56 Sugiyama TUBA1B MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
P68363 T73 Sugiyama TUBA1B FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
P68363 T80 Sugiyama TUBA1B KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
P68363 T82 Sugiyama TUBA1B VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
P68363 Y432 Sugiyama TUBA1B GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
P68363 Y83 Sugiyama TUBA1B PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
P78371 S144 Sugiyama CCT2 99D8.1 CCTB QTIIAGWREATKAAREALLssAVDHGsDEVKFRQDLMNIAG
P78371 T475 Sugiyama CCT2 99D8.1 CCTB GYDSADLVAQLRAAHsEGNttAGLDMREGTIGDMAILGITE
P83731 S38 Sugiyama RPL24 GRRYARTDGKVFQFLNAKCEsAFLSKRNPRQINWtVLyRRK
P83731 S7 Sugiyama RPL24 ______________MKVELCsFsGyKIYPGHGRRYARTDGK
P83731 S86 Sugiyama RPL24 EIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKAQRE
P83731 T52 Sugiyama RPL24 LNAKCEsAFLSKRNPRQINWtVLyRRKHKKGQsEEIQKKRT
P83731 T83 Sugiyama RPL24 QsEEIQKKRTRRAVKFQRAItGAsLADIMAKRNQKPEVRKA
P84098 S37 Sugiyama RPL19 CGKKKVWLDPNEtNEIANANsRQQIRKLIKDGLIIRKPVtV
P84098 T29 Sugiyama RPL19 RLAssVLRCGKKKVWLDPNEtNEIANANsRQQIRKLIKDGL
Q00839 T530 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 KTTWVTKHAAENPGKyNILGtNtIMDKMMVAGFKKQMADtG
Q00839 T532 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 TWVTKHAAENPGKyNILGtNtIMDKMMVAGFKKQMADtGKL
Q00839 T582 Sugiyama HNRNPU C1orf199 HNRPU SAFA U21.1 CLGKFIEIAARKKRNFILDQtNVsAAAQRRKMCLFAGFQRK
Q01105 S161 Sugiyama SET FDENPyFENKVLSKEFHLNEsGDPssKstEIKWKSGKDLTK
Q01105 T169 Sugiyama SET NKVLSKEFHLNEsGDPssKstEIKWKSGKDLTKRssQTQNK
Q02539 T102 Sugiyama H1-1 H1F1 HIST1H1A RIKLGIKsLVsKGtLVQtKGtGAsGsFKLNKKASSVETKPG
Q02539 T95 Sugiyama H1-1 H1F1 HIST1H1A DVEKNNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNKKAS
Q02539 T99 Sugiyama H1-1 H1F1 HIST1H1A NNSRIKLGIKsLVsKGtLVQtKGtGAsGsFKLNKKASSVET
Q02539 Y74 Sugiyama H1-1 H1F1 HIST1H1A SKERGGVSLAALKKALAAAGyDVEKNNSRIKLGIKsLVsKG
Q02878 S255 Sugiyama RPL6 TXREB1 tEKEKYEITEQRKIDQKAVDsQILPKIKAIPQLQGYLRSVF
Q02878 T91 Sugiyama RPL6 TXREB1 RKYSAAKSKVEKKKKEKVLAtVtKPVGGDKNGGTRVVKLRK
Q02878 T93 Sugiyama RPL6 TXREB1 YSAAKSKVEKKKKEKVLAtVtKPVGGDKNGGTRVVKLRKMP
Q05639 T432 Sugiyama EEF1A2 EEF1AL STN VESFSQYPPLGRFAVRDMRQtVAVGVIKNVEKKSGGAGKVT
Q06323 S55 Sugiyama PSME1 IFI5111 KKIsELDAFLKEPALNEANLsNLKAPLDIPVPDPVKEKEKE
Q06830 T166 Sugiyama PRDX1 PAGA PAGB TDPX2 DLPVGRsVDEtLRLVQAFQFtDKHGEVCPAGWKPGsDtIKP
Q06830 T18 Sugiyama PRDX1 PAGA PAGB TDPX2 ___MSSGNAKIGHPAPNFKAtAVMPDGQFKDIsLsDyKGKY
Q07020 S140 Sugiyama RPL18 ILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAPGtPH
Q07020 T136 Sugiyama RPL18 AGGKILtFDQLALDsPKGCGtVLLsGPRKGREVYRHFGKAP
Q07021 T214 Sugiyama C1QBP GC1QBP HABP1 SF2P32 GQEDEAEsDIFsIREVsFQstGESEWKDTNYTLNTDSLDWA
Q08043 T354 Sugiyama ACTN3 RRLHKPPRIQEKCQLEINFNtLQtKLRLSHRPAFMPSEGKL
Q08043 T357 Sugiyama ACTN3 HKPPRIQEKCQLEINFNtLQtKLRLSHRPAFMPSEGKLVSD
Q12906 T300 Sugiyama ILF3 DRBF MPHOSPH4 NF90 ASGIVMPDGSGIYDPCEKEAtDAIGHLDRQQREDItQsAQH
Q13069 S7 Sugiyama GAGE5 ______________MSWRGRsTyyWPRPRRYVQPPEVIGPM
Q13070 S7 Sugiyama GAGE6 ______________MSWRGRsTyyWPRPRRYVQPPEVIGPM
Q13153 T109 Sugiyama PAK1 FDAVTGEFTGMPEQWARLLQtsNITKsEQKKNPQAVLDVLE
Q13177 T108 Sugiyama PAK2 FDAVTGEFTGMPEQWARLLQtsNItKLEQKKNPQAVLDVLK
Q13310 T191 Sugiyama PABPC4 APP1 PABP4 GRFKSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELF
Q13310 Y194 Sugiyama PABPC4 APP1 PABP4 KSRKEREAELGAKAKEFtNVyIKNFGEEVDDEsLKELFsQF
Q13509 S115 Sugiyama TUBB3 TUBB4 SGAGNNWAKGHytEGAELVDsVLDVVRKECENCDCLQGFQL
Q13509 T107 Sugiyama TUBB3 TUBB4 PDNFIFGQSGAGNNWAKGHytEGAELVDsVLDVVRKECENC
Q13561 T315 Sugiyama DCTN2 DCTN50 KHKASVEDADTQSKVHQLyEtIQRWsPIASTLPELVQRLVT
Q13601 S284 Sugiyama KRR1 HRB2 KEYtPFPPPQPESQIDKELAsGEyFLKANQKKRQKMEAIKA
Q13765 S186 Sugiyama NACA HSD48 sEEEEVDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDI
Q13765 S191 Sugiyama NACA HSD48 VDEtGVEVKDIELVMsQANVsRAKAVRALKNNSNDIVNAIM
Q13885 S115 Sugiyama TUBB2A TUBB2 sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q13885 T107 Sugiyama TUBB2A TUBB2 PDNFVFGQsGAGNNWAKGHytEGAELVDsVLDVVRKESESC
Q14152 S1028 Sugiyama EIF3A EIF3S10 KIAA0139 NWRHADDDRPPRRGLDEDRGsWRtADEDRGPRRGMDDDRGP
Q14152 S1256 Sugiyama EIF3A EIF3S10 KIAA0139 EDRFRRPRDEGGWRRGPAEEsssWRDssRRDDRDRDDRRRE
Q14152 S584 Sugiyama EIF3A EIF3S10 KIAA0139 EHQRILARRQtIEERKERLEsLNIQREKEELEQREAELQKV
Q14157 T239 Sugiyama UBAP2L KIAA0144 NICE4 GNTWNNTGHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIF
Q14157 T241 Sugiyama UBAP2L KIAA0144 NICE4 TWNNTGHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIFtA
Q14157 T246 Sugiyama UBAP2L KIAA0144 NICE4 GHFEPDDGTSAWRtAtEEWGtEDWNEDLsEtKIFtAsNVss
Q14157 T256 Sugiyama UBAP2L KIAA0144 NICE4 AWRtAtEEWGtEDWNEDLsEtKIFtAsNVssVPLPAENVtI
Q14192 T234 Sugiyama FHL2 DRAL SLIM3 CDLyAKKCAGCTNPISGLGGtKyIsFEERQWHNDCFNCKKC
Q14247 T68 Sugiyama CTTN EMS1 GHQEHINIHKLRENVFQEHQtLKEKELETGPKASHGyGGKF
Q14320 S63 Sugiyama FAM50A DXS9928E HXC26 XAP5 SNIDKKFsAHyDAVEAELKsstVGLVtLNDMKAKQEALVKE
Q14320 T69 Sugiyama FAM50A DXS9928E HXC26 XAP5 FsAHyDAVEAELKsstVGLVtLNDMKAKQEALVKEREKQLA
Q14444 T303 Sugiyama CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 YTEQSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEV
Q14444 T306 Sugiyama CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 QSEVESTEYVNRQFMAEtQFtsGEKEQVDEWTVETVEVVNS
Q14677 T271 Sugiyama CLINT1 ENTH EPN4 EPNR KIAA0171 KDEEETVTTKHIHItQATEttttRHKRTANPsKtIDLGAAA
Q15056 S110 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 DEVDsLKEALtyDGALLGDRsLRVDIAEGRKQDKGGFGFRK
Q15056 S69 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 LPFNTVQGDIDAIFKDLsIRsVRLVRDKDTDKFKGFCyVEF
Q15056 T100 Sugiyama EIF4H KIAA0038 WBSCR1 WSCR1 KFKGFCyVEFDEVDsLKEALtyDGALLGDRsLRVDIAEGRK
Q15084 T166 Sugiyama PDIA6 ERP5 P5 TXNDC7 YSSGKQGRSDsSSKKDVIELtDDsFDKNVLDSEDVWMVEFY
Q15293 T100 Sugiyama RCN1 RCN sKERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNV
Q15293 T101 Sugiyama RCN1 RCN KERLGKIVDRIDNDGDGFVttEELKtWIKRVQKRyIFDNVA
Q15293 T211 Sugiyama RCN1 RCN FTAFLHPEEFEHMKEIVVLEtLEDIDKNGDGFVDQDEyIAD
Q15427 T14 Sugiyama SF3B4 SAP49 _______MAAGPISERNQDAtVyVGGLDEKVSEPLLWELFL
Q16204 T205 Sugiyama CCDC6 D10S170 TST1 TISKQLTLEQLRREKIDLENtLEQEQEALVNRLWKRMDKLE
Q16576 T10 Sugiyama RBBP7 RBAP46 ___________MAsKEMFEDtVEERVINEEYKIWKKNTPFL
Q16630 T404 Sugiyama CPSF6 CFIM68 yGRPPPYDRGDyGPPGREMDtARtPLsEAEFEEIMNRNRAI
Q16637 T25 Sugiyama SMN1 SMN SMNT; SMN2 SMNC sGGsGGGVPEQEDsVLFRRGtGQsDDsDIWDDtALIKAYDK
Q16637 T37 Sugiyama SMN1 SMN SMNT; SMN2 SMNC DsVLFRRGtGQsDDsDIWDDtALIKAYDKAVAsFKHALKNG
Q16658 T239 Sugiyama FSCN1 FAN1 HSN SNL GKVAFRDCEGRyLAPsGPsGtLKAGKATKVGKDELFALEQs
Q32P51 S95 Sugiyama HNRNPA1L2 HNRNPA1L TPHKVDGRVVEPKRAVsREDsQRPGAHLtVKKIFVGGIKED
Q3ZCM7 T72 Sugiyama TUBB8 NEASGGRYVPRAVLVDLEPGtMDsVRSGPFGQVFRPDNFIF
Q562R1 S240 Sugiyama ACTBL2 VALDFEQEMVRAAAssSPERsyELPDGQVItIGNERFRCPE
Q562R1 T250 Sugiyama ACTBL2 RAAAssSPERsyELPDGQVItIGNERFRCPEAIFQPSFLGI
Q58FF6 T165 Sugiyama HSP90AB4P DHGEPIDRDTKVILHLKEDQtEyLEERWVKEVVKKHPQFIG
Q58FF7 T169 Sugiyama HSP90AB3P HSP90BC DHGEPIGRGTKVILHLKEDQtEyLEERRVKEVVKKHsQFIG
Q58FG1 S251 Sugiyama HSP90AA4P HSP90AD HSPCAL2 EPIDEYCVQQLKEFEGKtLVsVTKEDLELPEDEEEKKKQEE
Q58FG1 T248 Sugiyama HSP90AA4P HSP90AD HSPCAL2 YTIEPIDEYCVQQLKEFEGKtLVsVTKEDLELPEDEEEKKK
Q5VTE0 T432 Sugiyama EEF1A1P5 EEF1AL3 VEsFSDyPPLGRFAVRDMRQtVAVGVIKAVDKKAAGAGKVT
Q6NUQ4 T55 Sugiyama TMEM214 PP446 RRALGEANGVWKYDLTPAIQtTSTLYERGFENIMKRQNKEQ
Q6PEY2 T334 Sugiyama TUBA3E ACCMLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q6PEY2 T337 Sugiyama TUBA3E MLYRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVGINy
Q6PEY2 T51 Sugiyama TUBA3E QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q6PEY2 T56 Sugiyama TUBA3E MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVVD
Q6PEY2 T73 Sugiyama TUBA3E FsEtGAGKHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLI
Q6PEY2 T80 Sugiyama TUBA3E KHVPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAA
Q6PEY2 T82 Sugiyama TUBA3E VPRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAASN
Q6PEY2 Y83 Sugiyama TUBA3E PRAVFVDLEPtVVDEVRtGtyRQLFHPEQLITGKEDAASNY
Q6S8J3 S1068 Sugiyama POTEE A26C1A POTE2 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q6S8J3 S939 Sugiyama POTEE A26C1A POTE2 VALDFEQEMAtAAssssLEKsyELPDGQVItIGNERFRCPE
Q6S8J3 T929 Sugiyama POTEE A26C1A POTE2 VRDIKEKLCyVALDFEQEMAtAAssssLEKsyELPDGQVIt
Q6S8J3 T949 Sugiyama POTEE A26C1A POTE2 tAAssssLEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q6UXH1 T300 Sugiyama CRELD2 UNQ185/PRO211 GYAREHGQCADVDECsLAEKtCVRKNENCYNTPGSYVCVCP
Q6ZMR3 S161 Sugiyama LDHAL6A LDHL2 DILTYVAWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIH
Q6ZMR3 S167 Sugiyama LDHAL6A LDHL2 AWKLSGFPKNRVIGsGCNLDsARFRYFIGQRLGIHSESCHG
Q71U36 T334 Sugiyama TUBA1A TUBA3 ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q71U36 T337 Sugiyama TUBA1A TUBA3 LLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVGINy
Q71U36 T51 Sugiyama TUBA1A TUBA3 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q71U36 T56 Sugiyama TUBA1A TUBA3 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q71U36 T73 Sugiyama TUBA1A TUBA3 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q71U36 T80 Sugiyama TUBA1A TUBA3 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q71U36 T82 Sugiyama TUBA1A TUBA3 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q71U36 Y432 Sugiyama TUBA1A TUBA3 GMEEGEFSEAREDMAALEKDyEEVGVDsVEGEGEEEGEEy_
Q71U36 Y83 Sugiyama TUBA1A TUBA3 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q7Z417 S652 Sugiyama NUFIP2 KIAA1321 PIG1 NtLLGsAKEQRYQRGLERNDsWGsFDLRAAIVYHTKEMEsI
Q7Z739 T177 Sugiyama YTHDF3 YPPSSLGRAITDGQAGFGNDtLSKVPGISsIEQGMTGLKIG
Q86U42 S225 Sugiyama PABPN1 PAB2 PABP2 CDKFSGHPKGFAyIEFSDKEsVRTSLALDEsLFRGRQIKVI
Q86U42 S235 Sugiyama PABPN1 PAB2 PABP2 FAyIEFSDKEsVRTSLALDEsLFRGRQIKVIPKRTNRPGIS
Q86V81 S8 Sugiyama ALYREF ALY BEF THOC4 _____________MADKMDMsLDDIIKLNRSQRGGRGGGRG
Q86V81 S94 Sugiyama ALYREF ALY BEF THOC4 PAPYSRPKQLPDKWQHDLFDsGFGGGAGVEtGGKLLVSNLD
Q86V81 T104 Sugiyama ALYREF ALY BEF THOC4 PDKWQHDLFDsGFGGGAGVEtGGKLLVSNLDFGVSDADIQE
Q8TAM6 S280 Sugiyama ERMN KIAA1189 TISYRKIRKGNTKQRIDEFEsMMHL________________
Q8WXX5 S215 Sugiyama DNAJC9 EEAKEAEMSRKELGLDEGVDsLKAAIQSRQKDRQKEMDNFL
Q92522 T55 Sugiyama H1-10 H1FX KRKNSKKKNQPGKySQLVVEtIRRLGERNGSSLAKIYTEAK
Q96B36 T233 Sugiyama AKT1S1 PRAS40 PDLDRIAAsMRALVLREAEDtQVFGDLPRPRLNtsDFQKLK
Q96HC4 T80 Sugiyama PDLIM5 ENH L9 GMTHLEAQNKIKGCTGsLNMtLQRAsAAPKPEPVPVQKGEP
Q96HE7 S143 Sugiyama ERO1A ERO1L UNQ434/PRO865 EANNLIEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSD
Q96HE7 T148 Sugiyama ERO1A ERO1L UNQ434/PRO865 IEECEQAERLGAVDEsLsEEtQKAVLQWTKHDDSSDNFCEA
Q96MH2 T196 Sugiyama HEXIM2 L3 GDSDGRGRAHGEFQRKDFsEtYERFHTESLQGRSKQELVRD
Q99497 T154 Sugiyama PARK7 MNGGHytysENRVEKDGLILtSRGPGTSFEFALAIVEALNG
Q99613 S865 Sugiyama EIF3C EIF3S8 HRTEPTAQQNLALQLAEKLGsLVENNERVFDHKQGtyGGyF
Q99832 T57 Sugiyama CCT7 CCTH NIP7-1 RTTLGPRGMDKLIVDGRGKAtIsNDGAtILKLLDVVHPAAK
Q99832 T64 Sugiyama CCT7 CCTH NIP7-1 GMDKLIVDGRGKAtIsNDGAtILKLLDVVHPAAKTLVDIAK
Q9BQE3 T334 Sugiyama TUBA1C TUBA6 ACCLLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVG
Q9BQE3 T337 Sugiyama TUBA1C TUBA6 LLyRGDVVPKDVNAAIAtIKtKRTIQFVDWCPTGFKVGINy
Q9BQE3 T51 Sugiyama TUBA1C TUBA6 QPDGQMPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLE
Q9BQE3 T56 Sugiyama TUBA1C TUBA6 MPSDKtIGGGDDsFNtFFsEtGAGKHVPRAVFVDLEPtVID
Q9BQE3 T73 Sugiyama TUBA1C TUBA6 FsEtGAGKHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLI
Q9BQE3 T80 Sugiyama TUBA1C TUBA6 KHVPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAA
Q9BQE3 T82 Sugiyama TUBA1C TUBA6 VPRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANN
Q9BQE3 Y83 Sugiyama TUBA1C TUBA6 PRAVFVDLEPtVIDEVRtGtyRQLFHPEQLItGKEDAANNy
Q9BVA1 S115 Sugiyama TUBB2B sGAGNNWAKGHytEGAELVDsVLDVVRKESESCDCLQGFQL
Q9BVA1 T107 Sugiyama TUBB2B PDNFVFGQsGAGNNWAKGHytEGAELVDsVLDVVRKESESC
Q9BYX7 S239 Sugiyama POTEKP ACTBL3 FKSG30 VALDSEQEMAMAASSSSVEKsyELPDGQVItIGNERFRCPE
Q9BYX7 S368 Sugiyama POTEKP ACTBL3 FKSG30 SLSTFQQMWISKQEyDEsGPsIVHRKCF_____________
Q9BYX7 T249 Sugiyama POTEKP ACTBL3 FKSG30 MAASSSSVEKsyELPDGQVItIGNERFRCPEALFQPCFLGM
Q9C0C2 T1323 Sugiyama TNKS1BP1 KIAA1741 TAB182 ELGVGQMDWGNNLGLRDLEVtCDPDsGGsQGLRGCGVGQMD
Q9H0C5 S273 Sugiyama BTBD1 C15orf1 NS5ATP8 QRQQLPVTFGNKQKVLGKALsLIRFPLMTIEEFAAGPAQSG
Q9H0L4 T341 Sugiyama CSTF2T KIAA0689 PGGLPPRGLLGDAPNDPRGGtLLsVtGEVEPRGYLGPPHQG
Q9H0L4 T346 Sugiyama CSTF2T KIAA0689 PRGLLGDAPNDPRGGtLLsVtGEVEPRGYLGPPHQGPPMHH
Q9NQ39 T159 Sugiyama RPS10P5 RPS10L RRCSVPPGADKKAEAGAGsAtEFQFRGRCGRGRGQPPQ___
Q9NZL9 T34 Sugiyama MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995 PGsCRLVEEEVNIPNRRVLVtGAtGLLGRAVHKEFQQNNWH
Q9NZL9 T37 Sugiyama MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995 CRLVEEEVNIPNRRVLVtGAtGLLGRAVHKEFQQNNWHAVG
Q9UBR2 T172 Sugiyama CTSZ ETCNNYQAKDQECDKFNQCGtCNEFKECHAIRNYTLWRVGD
Q9UHV9 T103 Sugiyama PFDN2 PFD2 HSPC231 VKEVLPALENNKEQIQKIIEtLtQQLQAKGKELNEFREKHN
Q9UHV9 T105 Sugiyama PFDN2 PFD2 HSPC231 EVLPALENNKEQIQKIIEtLtQQLQAKGKELNEFREKHNIR
Q9UI15 T190 Sugiyama TAGLN3 NP25 GQNVIGLQMGSNKGAsQAGMtGyGMPRQIM___________
Q9ULW6 T342 Sugiyama NAP1L2 BPX GTAIEYSTGCEIDWNEGKNVtLKtIKKKQKHRIWGTIRTVT
Q9ULW6 T345 Sugiyama NAP1L2 BPX IEYSTGCEIDWNEGKNVtLKtIKKKQKHRIWGTIRTVTEDF
Q9UNF1 T117 Sugiyama MAGED2 BCG1 AENKSLAADTKKQNADPQAVtMPATEtKKVSHVADTKVNTK
Q9UNF1 T123 Sugiyama MAGED2 BCG1 AADTKKQNADPQAVtMPATEtKKVSHVADTKVNTKAQETEA
Q9UNF1 T87 Sugiyama MAGED2 BCG1 tEVsKtPEAREAPAtQAssttQLtDtQVLAAENKSLAADTK
Q9UNF1 T90 Sugiyama MAGED2 BCG1 sKtPEAREAPAtQAssttQLtDtQVLAAENKSLAADTKKQN
Q9UNF1 T92 Sugiyama MAGED2 BCG1 tPEAREAPAtQAssttQLtDtQVLAAENKSLAADTKKQNAD
Q9UNX3 T8 Sugiyama RPL26L1 RPL26P1 _____________MKFNPFVtsDRsKNRKRHFNAPSHVRRK
Q9UQ80 T200 Sugiyama PA2G4 EBP1 TPIEGMLSHQLKQHVIDGEKtIIQNPTDQQKKDHEKAEFEV
Q9UQ80 T386 Sugiyama PA2G4 EBP1 tQKKKKKKAsKtAENAtsGEtLEENEAGD____________
Q9Y247 S63 Sugiyama FAM50B X5L SQVDKRFSAHyDAVEAELKsstVGLVtLNDMKARQEALVRE
Q9Y247 T69 Sugiyama FAM50B X5L FSAHyDAVEAELKsstVGLVtLNDMKARQEALVRERERQLA
Q9Y2B0 S115 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 QIDPstHRKNYVRVVGRNGEssELDLQGIRIDsDISGtLKF
Q9Y2B0 S63 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 AQVDPKKTIQMGsFRINPDGsQsVVEVPyARsEAHLtELLE
Q9Y2B0 T132 Sugiyama CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426 NGEssELDLQGIRIDsDISGtLKFACEsIVEEyEDELIEFF
Q9Y2W1 T227 Sugiyama THRAP3 BCLAF2 TRAP150 sGGtsQDTKAsEssKPWPDAtyGtGsAsRAsAVsELsPRER
Q9Y2W1 T230 Sugiyama THRAP3 BCLAF2 TRAP150 tsQDTKAsEssKPWPDAtyGtGsAsRAsAVsELsPRERsPA
Q9Y2W1 Y228 Sugiyama THRAP3 BCLAF2 TRAP150 GGtsQDTKAsEssKPWPDAtyGtGsAsRAsAVsELsPRERs
Q9Y2X3 S434 Sugiyama NOP58 NOL5 NOP5 HSPC120 AKTEKYEHKSEVKtyDPSGDstLPtCsKKRKIEQVDKEDEI
Q9Y3F4 S228 Sugiyama STRAP MAWD UNRIP FHSAVSLDPIKsFEAPAtINsAsLHPEKEFLVAGGEDFKLy
Q9Y3F4 S230 Sugiyama STRAP MAWD UNRIP SAVSLDPIKsFEAPAtINsAsLHPEKEFLVAGGEDFKLyKy
Q9Y3F4 T225 Sugiyama STRAP MAWD UNRIP SIAFHSAVSLDPIKsFEAPAtINsAsLHPEKEFLVAGGEDF
Q9Y3F4 T48 Sugiyama STRAP MAWD UNRIP YGYFLISACKDGKPMLRQGDtGDWIGtFLGHKGAVWGAtLN
Q9Y3F4 T54 Sugiyama STRAP MAWD UNRIP SACKDGKPMLRQGDtGDWIGtFLGHKGAVWGAtLNKDATKA
Q9Y3S2 S25 Sugiyama ZNF330 NOA36 KTGARKKAENRREREKQLRAsRstIDLAKHPCNASMECDKC
Q9Y3S2 S27 Sugiyama ZNF330 NOA36 GARKKAENRREREKQLRAsRstIDLAKHPCNASMECDKCQR
Q9Y3S2 T28 Sugiyama ZNF330 NOA36 ARKKAENRREREKQLRAsRstIDLAKHPCNASMECDKCQRR
Q9Y5J9 T71 Sugiyama TIMM8B DDP2 DDPL TIM8B RTENCLsSCVDRFIDTTLAItSRFAQIVQKGGQ________
Q9Y5L4 S57 Sugiyama TIMM13 TIM13B TIMM13A TIMM13B ELLQRMTDKCFRKCIGKPGGsLDNSEQKCIAMCMDRyMDAW
Site Promiscuity
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
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name reactome_id p -log10p ref_path ref_path_lowest
Signal Transduction R-HSA-162582 6.100736e-08 7.215 0 0
L1CAM interactions R-HSA-373760 7.630482e-07 6.117 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 3.775608e-06 5.423 0 0
Recycling pathway of L1 R-HSA-437239 1.012195e-05 4.995 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 1.125906e-05 4.948 0 0
PKR-mediated signaling R-HSA-9833482 1.525813e-05 4.816 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.703839e-05 4.769 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 1.814620e-05 4.741 0 0
Cell Cycle R-HSA-1640170 2.335288e-05 4.632 0 0
Oncogene Induced Senescence R-HSA-2559585 2.650351e-05 4.577 0 0
Axon guidance R-HSA-422475 2.603900e-05 4.584 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 3.824918e-05 4.417 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 3.880019e-05 4.411 0 0
Signaling by ALK in cancer R-HSA-9700206 3.880019e-05 4.411 0 0
Selective autophagy R-HSA-9663891 4.566026e-05 4.340 0 0
Mitotic Prometaphase R-HSA-68877 4.694484e-05 4.328 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 5.649365e-05 4.248 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 5.744492e-05 4.241 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 5.843614e-05 4.233 0 0
Aggrephagy R-HSA-9646399 6.699010e-05 4.174 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 7.362878e-05 4.133 0 0
Kinesins R-HSA-983189 7.675550e-05 4.115 0 0
Transport of connexons to the plasma membrane R-HSA-190872 9.673620e-05 4.014 0 0
Nervous system development R-HSA-9675108 1.169411e-04 3.932 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.606640e-04 3.794 0 0
Autophagy R-HSA-9612973 1.605581e-04 3.794 0 0
Nuclear Receptor transcription pathway R-HSA-383280 1.785973e-04 3.748 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 1.807609e-04 3.743 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 1.965111e-04 3.707 0 0
MHC class II antigen presentation R-HSA-2132295 2.046995e-04 3.689 0 0
Cell Cycle, Mitotic R-HSA-69278 2.273864e-04 3.643 0 0
Separation of Sister Chromatids R-HSA-2467813 2.845927e-04 3.546 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 3.898975e-04 3.409 0 0
Chaperonin-mediated protein folding R-HSA-390466 5.003067e-04 3.301 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.500497e-04 3.260 0 0
Sema4D in semaphorin signaling R-HSA-400685 5.763408e-04 3.239 0 0
Mitotic G2-G2/M phases R-HSA-453274 5.675179e-04 3.246 0 0
Mitotic Anaphase R-HSA-68882 5.464717e-04 3.262 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 5.781267e-04 3.238 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 6.685030e-04 3.175 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 6.730302e-04 3.172 0 0
FOXO-mediated transcription of cell death genes R-HSA-9614657 6.765698e-04 3.170 0 0
RUNX3 regulates p14-ARF R-HSA-8951936 8.561445e-04 3.067 0 0
Protein folding R-HSA-391251 8.660541e-04 3.062 0 0
Macroautophagy R-HSA-1632852 9.879648e-04 3.005 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 1.158066e-03 2.936 0 0
Amplification of signal from the kinetochores R-HSA-141424 1.328657e-03 2.877 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 1.328657e-03 2.877 0 0
Signaling by NOTCH1 R-HSA-1980143 1.705852e-03 2.768 0 0
Membrane Trafficking R-HSA-199991 1.867956e-03 2.729 0 0
RAF/MAP kinase cascade R-HSA-5673001 1.977303e-03 2.704 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 2.116697e-03 2.674 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.123318e-03 2.673 0 0
Muscle contraction R-HSA-397014 2.246562e-03 2.648 0 0
Death Receptor Signaling R-HSA-73887 2.378150e-03 2.624 0 0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling R-HSA-2644607 2.626196e-03 2.581 0 0
FBXW7 Mutants and NOTCH1 in Cancer R-HSA-2644605 2.626196e-03 2.581 0 0
NRAGE signals death through JNK R-HSA-193648 2.739498e-03 2.562 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 2.657647e-03 2.576 0 0
G2/M Transition R-HSA-69275 2.759869e-03 2.559 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.625155e-03 2.581 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.739498e-03 2.562 0 0
MAPK family signaling cascades R-HSA-5683057 2.772397e-03 2.557 0 0
Gap junction assembly R-HSA-190861 2.794333e-03 2.554 0 0
Signal attenuation R-HSA-74749 2.983641e-03 2.525 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 3.148723e-03 2.502 0 0
COPI-mediated anterograde transport R-HSA-6807878 3.762142e-03 2.425 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.764424e-03 2.424 0 0
Regulation of beta-cell development R-HSA-186712 3.685049e-03 2.434 0 0
Interleukin-2 signaling R-HSA-9020558 3.875717e-03 2.412 0 0
IRS activation R-HSA-74713 4.035291e-03 2.394 0 0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 4.035291e-03 2.394 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 4.086536e-03 2.389 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 4.207431e-03 2.376 0 0
Signaling by Interleukins R-HSA-449147 4.447546e-03 2.352 0 0
Post NMDA receptor activation events R-HSA-438064 4.628281e-03 2.335 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 4.666198e-03 2.331 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.992274e-03 2.302 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 4.932834e-03 2.307 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 5.323391e-03 2.274 0 0
Signaling by PTK6 R-HSA-8848021 5.323391e-03 2.274 0 0
Hedgehog 'off' state R-HSA-5610787 4.992274e-03 2.302 0 0
Signaling by Hedgehog R-HSA-5358351 5.017272e-03 2.300 0 0
Signaling by ALK R-HSA-201556 5.180755e-03 2.286 0 0
Interleukin-12 signaling R-HSA-9020591 5.232283e-03 2.281 0 0
Regulation of gene expression in beta cells R-HSA-210745 5.383298e-03 2.269 0 0
M Phase R-HSA-68886 5.435099e-03 2.265 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 5.529203e-03 2.257 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 5.828965e-03 2.234 0 0
IRAK1 recruits IKK complex R-HSA-937039 6.167765e-03 2.210 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 6.167765e-03 2.210 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.757848e-03 2.240 0 0
Signaling by LTK R-HSA-9842663 6.167765e-03 2.210 0 0
Interleukin-37 signaling R-HSA-9008059 6.143944e-03 2.212 0 0
Sensory processing of sound R-HSA-9659379 6.615491e-03 2.179 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 6.757927e-03 2.170 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 7.134621e-03 2.147 0 0
IKBKB deficiency causes SCID R-HSA-5602636 8.221407e-03 2.085 0 0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 8.221407e-03 2.085 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 8.031993e-03 2.095 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 8.031993e-03 2.095 0 0
NFE2L2 regulating tumorigenic genes R-HSA-9818030 7.592505e-03 2.120 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 7.895256e-03 2.103 0 0
Regulation of NFE2L2 gene expression R-HSA-9818749 8.031993e-03 2.095 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 7.993826e-03 2.097 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 7.603225e-03 2.119 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 8.105408e-03 2.091 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 9.742504e-03 2.011 0 0
Gap junction trafficking R-HSA-190828 9.761310e-03 2.010 0 0
Potassium Channels R-HSA-1296071 9.936248e-03 2.003 0 0
Striated Muscle Contraction R-HSA-390522 9.979810e-03 2.001 0 0
Interleukin receptor SHC signaling R-HSA-912526 1.047649e-02 1.980 0 0
RAF activation R-HSA-5673000 1.115678e-02 1.952 0 0
Cell-extracellular matrix interactions R-HSA-446353 1.105511e-02 1.956 0 0
NOD1/2 Signaling Pathway R-HSA-168638 1.115678e-02 1.952 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 1.023699e-02 1.990 0 0
Cellular responses to stimuli R-HSA-8953897 1.153522e-02 1.938 0 0
Apoptotic execution phase R-HSA-75153 1.179822e-02 1.928 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 1.187580e-02 1.925 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.198515e-02 1.921 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 1.419324e-02 1.848 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 1.419324e-02 1.848 0 0
Diseases of cellular response to stress R-HSA-9675132 1.419324e-02 1.848 0 0
Diseases of Cellular Senescence R-HSA-9630747 1.419324e-02 1.848 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 1.419324e-02 1.848 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 1.419324e-02 1.848 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 1.419324e-02 1.848 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 1.419324e-02 1.848 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 1.419324e-02 1.848 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 1.419324e-02 1.848 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 1.419324e-02 1.848 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 1.419324e-02 1.848 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 1.419324e-02 1.848 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 1.419324e-02 1.848 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 1.373802e-02 1.862 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.292433e-02 1.889 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 1.261144e-02 1.899 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 1.261144e-02 1.899 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 1.261144e-02 1.899 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 1.261144e-02 1.899 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 1.261144e-02 1.899 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 1.474602e-02 1.831 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.434120e-02 1.843 0 0
Intraflagellar transport R-HSA-5620924 1.412566e-02 1.850 0 0
Interleukin-12 family signaling R-HSA-447115 1.250201e-02 1.903 0 0
Neuronal System R-HSA-112316 1.427809e-02 1.845 0 0
Signaling by NOTCH4 R-HSA-9013694 1.276506e-02 1.894 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 1.539882e-02 1.813 0 0
Gap junction trafficking and regulation R-HSA-157858 1.540472e-02 1.812 0 0
Cell Cycle Checkpoints R-HSA-69620 1.556973e-02 1.808 0 0
Semaphorin interactions R-HSA-373755 1.590648e-02 1.798 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 1.732949e-02 1.761 0 0
EPH-Ephrin signaling R-HSA-2682334 1.819514e-02 1.740 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 1.842305e-02 1.735 0 0
Cellular Senescence R-HSA-2559583 1.943316e-02 1.711 0 0
Cellular responses to stress R-HSA-2262752 1.958529e-02 1.708 0 0
Interleukin-2 family signaling R-HSA-451927 2.033383e-02 1.692 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 2.068653e-02 1.684 0 0
Platelet sensitization by LDL R-HSA-432142 2.068653e-02 1.684 0 0
Smooth Muscle Contraction R-HSA-445355 2.134684e-02 1.671 0 0
Other interleukin signaling R-HSA-449836 2.369976e-02 1.625 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 2.406798e-02 1.619 0 0
Signaling by NOTCH R-HSA-157118 2.762841e-02 1.559 0 0
Cytokine Signaling in Immune system R-HSA-1280215 2.571336e-02 1.590 0 0
TNF signaling R-HSA-75893 2.673383e-02 1.573 0 0
Regulation of CDH1 Function R-HSA-9764561 2.871776e-02 1.542 0 0
NADE modulates death signalling R-HSA-205025 3.012494e-02 1.521 0 0
NFE2L2 regulating ER-stress associated genes R-HSA-9818035 3.012494e-02 1.521 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 3.012494e-02 1.521 0 0
Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 3.060088e-02 1.514 0 0
Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 3.060088e-02 1.514 0 0
Signaling by GSK3beta mutants R-HSA-5339716 3.060088e-02 1.514 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 3.135138e-02 1.504 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 3.316426e-02 1.479 0 0
NFE2L2 regulating inflammation associated genes R-HSA-9818026 3.983127e-02 1.400 0 0
G2 Phase R-HSA-68911 3.983127e-02 1.400 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 3.596136e-02 1.444 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 3.596136e-02 1.444 0 0
Signaling by CTNNB1 phospho-site mutants R-HSA-4839743 3.596136e-02 1.444 0 0
CTNNB1 S37 mutants aren't phosphorylated R-HSA-5358749 3.596136e-02 1.444 0 0
CTNNB1 S33 mutants aren't phosphorylated R-HSA-5358747 3.596136e-02 1.444 0 0
CTNNB1 T41 mutants aren't phosphorylated R-HSA-5358752 3.596136e-02 1.444 0 0
CTNNB1 S45 mutants aren't phosphorylated R-HSA-5358751 3.596136e-02 1.444 0 0
Notch-HLH transcription pathway R-HSA-350054 3.830805e-02 1.417 0 0
Centrosome maturation R-HSA-380287 3.536164e-02 1.451 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 3.426751e-02 1.465 0 0
Mitophagy R-HSA-5205647 3.864804e-02 1.413 0 0
RUNX3 regulates NOTCH signaling R-HSA-8941856 3.596136e-02 1.444 0 0
PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849468 3.983127e-02 1.400 0 0
Cellular response to chemical stress R-HSA-9711123 3.801754e-02 1.420 0 0
NrCAM interactions R-HSA-447038 3.983127e-02 1.400 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 3.536164e-02 1.451 0 0
Regulation of TNFR1 signaling R-HSA-5357905 3.628428e-02 1.440 0 0
G alpha (12/13) signalling events R-HSA-416482 4.200431e-02 1.377 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 4.260963e-02 1.370 0 0
Growth hormone receptor signaling R-HSA-982772 4.260963e-02 1.370 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 4.359277e-02 1.361 0 0
Evasion of Oncogene Induced Senescence Due to p14ARF Defects R-HSA-9646303 4.372864e-02 1.359 0 0
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects R-HSA-9646304 4.372864e-02 1.359 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 4.387834e-02 1.358 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 4.645148e-02 1.333 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 4.717221e-02 1.326 0 0
Voltage gated Potassium channels R-HSA-1296072 4.951133e-02 1.305 0 0
Programmed Cell Death R-HSA-5357801 4.962489e-02 1.304 0 0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 5.054310e-02 1.296 0 0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 5.054310e-02 1.296 0 0
GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5635851 5.054310e-02 1.296 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 5.054310e-02 1.296 0 0
Negative feedback regulation of MAPK pathway R-HSA-5674499 5.054310e-02 1.296 0 0
IkBA variant leads to EDA-ID R-HSA-5603029 5.054310e-02 1.296 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 5.054310e-02 1.296 0 0
SLC15A4:TASL-dependent IRF5 activation R-HSA-9860276 5.054310e-02 1.296 0 0
Beta-catenin phosphorylation cascade R-HSA-196299 5.470153e-02 1.262 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 6.179998e-02 1.209 0 0
Phase 4 - resting membrane potential R-HSA-5576886 6.179998e-02 1.209 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.707630e-02 1.244 0 0
RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.470153e-02 1.262 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.470153e-02 1.262 0 0
TRP channels R-HSA-3295583 5.707630e-02 1.244 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 5.687097e-02 1.245 0 0
Vesicle-mediated transport R-HSA-5653656 5.968949e-02 1.224 0 0
STAT3 nuclear events downstream of ALK signaling R-HSA-9701898 5.470153e-02 1.262 0 0
Transmission across Chemical Synapses R-HSA-112315 6.177341e-02 1.209 0 0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-210744 6.179998e-02 1.209 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 5.470153e-02 1.262 0 0
Signaling by VEGF R-HSA-194138 5.350139e-02 1.272 0 0
FOXO-mediated transcription R-HSA-9614085 6.223790e-02 1.206 0 0
Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 6.241389e-02 1.205 0 0
Interaction between L1 and Ankyrins R-HSA-445095 6.241389e-02 1.205 0 0
Signaling by NOTCH3 R-HSA-9012852 6.621288e-02 1.179 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 6.651849e-02 1.177 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 6.800475e-02 1.167 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 7.022126e-02 1.154 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 7.089501e-02 1.149 0 0
Deubiquitination R-HSA-5688426 7.326798e-02 1.135 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 7.384522e-02 1.132 0 0
Diseases of Telomere Maintenance R-HSA-9673013 8.554762e-02 1.068 0 0
Defective Inhibition of DNA Recombination at Telomere R-HSA-9670621 8.554762e-02 1.068 0 0
Alternative Lengthening of Telomeres (ALT) R-HSA-9006821 8.554762e-02 1.068 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791 8.554762e-02 1.068 0 0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations R-HSA-9670613 8.554762e-02 1.068 0 0
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function R-HSA-9645722 8.554762e-02 1.068 0 0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations R-HSA-9670615 8.554762e-02 1.068 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697 8.554762e-02 1.068 0 0
Defective Mismatch Repair Associated With MSH6 R-HSA-5632968 8.554762e-02 1.068 0 0
IFNG signaling activates MAPKs R-HSA-9732724 7.456562e-02 1.127 0 0
PTK6 Expression R-HSA-8849473 7.456562e-02 1.127 0 0
SOS-mediated signalling R-HSA-112412 7.456562e-02 1.127 0 0
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840 7.456562e-02 1.127 0 0
Type I hemidesmosome assembly R-HSA-446107 8.768544e-02 1.057 0 0
Signaling by MRAS-complex mutants R-HSA-9660537 8.768544e-02 1.057 0 0
Activation of RAS in B cells R-HSA-1169092 8.768544e-02 1.057 0 0
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842 8.768544e-02 1.057 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 7.993109e-02 1.097 0 0
GABA B receptor activation R-HSA-977444 7.609790e-02 1.119 0 0
Activation of GABAB receptors R-HSA-991365 7.609790e-02 1.119 0 0
Signaling by ERBB2 R-HSA-1227986 8.761909e-02 1.057 0 0
Diseases of mitotic cell cycle R-HSA-9675126 9.281934e-02 1.032 0 0
Cation-coupled Chloride cotransporters R-HSA-426117 7.456562e-02 1.127 0 0
Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-164940 8.768544e-02 1.057 0 0
Inwardly rectifying K+ channels R-HSA-1296065 9.281934e-02 1.032 0 0
G alpha (q) signalling events R-HSA-416476 9.181095e-02 1.037 0 0
Signaling by WNT in cancer R-HSA-4791275 9.281934e-02 1.032 0 0
Formation of editosomes by ADAR proteins R-HSA-77042 8.554762e-02 1.068 0 0
Inhibition of PKR R-HSA-169131 8.554762e-02 1.068 0 0
Cilium Assembly R-HSA-5617833 9.117502e-02 1.040 0 0
G1 Phase R-HSA-69236 8.638141e-02 1.064 0 0
Cyclin D associated events in G1 R-HSA-69231 8.638141e-02 1.064 0 0
PLC beta mediated events R-HSA-112043 9.230584e-02 1.035 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 8.625756e-02 1.064 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 8.625756e-02 1.064 0 0
ZBP1(DAI) mediated induction of type I IFNs R-HSA-1606322 8.546356e-02 1.068 0 0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938 7.719614e-02 1.112 0 0
MECP2 regulates transcription factors R-HSA-9022707 7.456562e-02 1.127 0 0
Apoptotic factor-mediated response R-HSA-111471 8.546356e-02 1.068 0 0
Interleukin-1 family signaling R-HSA-446652 8.419043e-02 1.075 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 7.436664e-02 1.129 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 9.408890e-02 1.026 0 0
STING mediated induction of host immune responses R-HSA-1834941 9.408890e-02 1.026 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 9.712535e-02 1.013 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 9.735292e-02 1.012 0 0
Signaling downstream of RAS mutants R-HSA-9649948 9.735292e-02 1.012 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 9.735292e-02 1.012 0 0
Signaling by RAS mutants R-HSA-6802949 9.735292e-02 1.012 0 0
NFG and proNGF binds to p75NTR R-HSA-205017 1.255402e-01 0.901 0 0
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 1.255402e-01 0.901 0 0
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750 1.255402e-01 0.901 0 0
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693 1.255402e-01 0.901 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5660724 1.255402e-01 0.901 0 0
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700 1.255402e-01 0.901 0 0
Defective PGM1 causes PGM1-CDG R-HSA-5609974 1.255402e-01 0.901 0 0
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794 1.255402e-01 0.901 0 0
TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 1.255402e-01 0.901 0 0
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) R-HSA-5619081 1.255402e-01 0.901 0 0
Defective SLC12A3 causes Gitelman syndrome (GS) R-HSA-5619087 1.255402e-01 0.901 0 0
NFE2L2 regulating MDR associated enzymes R-HSA-9818032 1.014281e-01 0.994 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.157143e-01 0.937 0 0
Activation of Ca-permeable Kainate Receptor R-HSA-451308 1.157143e-01 0.937 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.304704e-01 0.884 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 1.304704e-01 0.884 0 0
Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 1.304704e-01 0.884 0 0
APC truncation mutants have impaired AXIN binding R-HSA-5467337 1.304704e-01 0.884 0 0
AXIN missense mutants destabilize the destruction complex R-HSA-5467340 1.304704e-01 0.884 0 0
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 1.030551e-01 0.987 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.219392e-01 0.914 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 1.219392e-01 0.914 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 1.066253e-01 0.972 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 1.089918e-01 0.963 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 1.020762e-01 0.991 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 1.020762e-01 0.991 0 0
AURKA Activation by TPX2 R-HSA-8854518 1.177009e-01 0.929 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.272044e-01 0.895 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 1.138566e-01 0.944 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.304704e-01 0.884 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 1.111213e-01 0.954 0 0
Regulation of CDH11 function R-HSA-9762292 1.157143e-01 0.937 0 0
PI3K/AKT activation R-HSA-198203 1.157143e-01 0.937 0 0
IGF1R signaling cascade R-HSA-2428924 1.071570e-01 0.970 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 1.014281e-01 0.994 0 0
Regulated Necrosis R-HSA-5218859 1.287418e-01 0.890 0 0
Adipogenesis R-HSA-9843745 1.279573e-01 0.893 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 1.123658e-01 0.949 0 0
Caspase activation via Dependence Receptors in the absence of ligand R-HSA-418889 1.014281e-01 0.994 0 0
HSF1-dependent transactivation R-HSA-3371571 1.276466e-01 0.894 0 0
NFE2L2 regulating anti-oxidant/detoxification enzymes R-HSA-9818027 1.066253e-01 0.972 0 0
G-protein mediated events R-HSA-112040 1.231603e-01 0.910 0 0
TGFBR3 regulates FGF2 signaling R-HSA-9839397 1.255402e-01 0.901 0 0
Defective Mismatch Repair Associated With MSH2 R-HSA-5632928 1.255402e-01 0.901 0 0
Regulation of gene expression in early pancreatic precursor cells R-HSA-210747 1.304704e-01 0.884 0 0
Ionotropic activity of kainate receptors R-HSA-451306 1.304704e-01 0.884 0 0
Signaling by APC mutants R-HSA-4839744 1.304704e-01 0.884 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 1.222392e-01 0.913 0 0
GPER1 signaling R-HSA-9634597 1.089918e-01 0.963 0 0
Apoptosis R-HSA-109581 1.142138e-01 0.942 0 0
Breakdown of the nuclear lamina R-HSA-352238 1.255402e-01 0.901 0 0
Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 1.157143e-01 0.937 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 1.197940e-01 0.922 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 1.197940e-01 0.922 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 1.197940e-01 0.922 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 1.219392e-01 0.914 0 0
Regulation of TP53 Activity R-HSA-5633007 1.077682e-01 0.968 0 0
Cell junction organization R-HSA-446728 1.261670e-01 0.899 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 1.219392e-01 0.914 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.210192e-01 0.917 0 0
Cell-Cell communication R-HSA-1500931 1.237287e-01 0.908 0 0
Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866907 1.014281e-01 0.994 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 1.219392e-01 0.914 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.289414e-01 0.890 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 1.304704e-01 0.884 0 0
FOXO-mediated transcription of cell cycle genes R-HSA-9617828 1.219392e-01 0.914 0 0
ChREBP activates metabolic gene expression R-HSA-163765 1.304704e-01 0.884 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.071570e-01 0.970 0 0
Signaling by Leptin R-HSA-2586552 1.157143e-01 0.937 0 0
Mitochondrial calcium ion transport R-HSA-8949215 1.219392e-01 0.914 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 1.318210e-01 0.880 0 0
Potassium transport channels R-HSA-1296067 1.637861e-01 0.786 0 0
Axonal growth stimulation R-HSA-209563 2.003615e-01 0.698 0 0
Defective GCLC causes HAGGSD R-HSA-5578999 2.003615e-01 0.698 0 0
Classical Kir channels R-HSA-1296053 2.003615e-01 0.698 0 0
HCN channels R-HSA-1296061 2.353392e-01 0.628 0 0
Nucleotide catabolism defects R-HSA-9735786 2.353392e-01 0.628 0 0
Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine R-HSA-9735763 2.353392e-01 0.628 0 0
Signaling by LRP5 mutants R-HSA-5339717 2.353392e-01 0.628 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 2.353392e-01 0.628 0 0
Defective LFNG causes SCDO3 R-HSA-5083630 2.353392e-01 0.628 0 0
Defective SLC1A3 causes episodic ataxia 6 (EA6) R-HSA-5619062 2.687890e-01 0.571 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 1.456280e-01 0.837 0 0
p75NTR recruits signalling complexes R-HSA-209543 1.611240e-01 0.793 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 1.611240e-01 0.793 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 1.611240e-01 0.793 0 0
SLIT2:ROBO1 increases RHOA activity R-HSA-8985586 3.007775e-01 0.522 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 3.007775e-01 0.522 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 3.007775e-01 0.522 0 0
Signaling by RNF43 mutants R-HSA-5340588 3.007775e-01 0.522 0 0
Adenylate cyclase activating pathway R-HSA-170660 1.769000e-01 0.752 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 1.769000e-01 0.752 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.929018e-01 0.715 0 0
Erythropoietin activates STAT5 R-HSA-9027283 3.313684e-01 0.480 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 3.313684e-01 0.480 0 0
Erythropoietin activates RAS R-HSA-9027284 2.090797e-01 0.680 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 2.090797e-01 0.680 0 0
SHC1 events in EGFR signaling R-HSA-180336 2.090797e-01 0.680 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 2.090797e-01 0.680 0 0
Displacement of DNA glycosylase by APEX1 R-HSA-110357 3.606227e-01 0.443 0 0
RUNX3 regulates WNT signaling R-HSA-8951430 3.606227e-01 0.443 0 0
CHL1 interactions R-HSA-447041 3.606227e-01 0.443 0 0
Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 3.606227e-01 0.443 0 0
PP2A-mediated dephosphorylation of key metabolic factors R-HSA-163767 3.606227e-01 0.443 0 0
Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912399 3.606227e-01 0.443 0 0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 1.630055e-01 0.788 0 0
Activation of G protein gated Potassium channels R-HSA-1296041 1.630055e-01 0.788 0 0
G protein gated Potassium channels R-HSA-1296059 1.630055e-01 0.788 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 2.417838e-01 0.617 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 1.848950e-01 0.733 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 2.582289e-01 0.588 0 0
ROBO receptors bind AKAP5 R-HSA-9010642 3.885988e-01 0.410 0 0
phospho-PLA2 pathway R-HSA-111995 3.885988e-01 0.410 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.885988e-01 0.410 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 2.746875e-01 0.561 0 0
Late endosomal microautophagy R-HSA-9615710 2.074971e-01 0.683 0 0
Impaired BRCA2 binding to RAD51 R-HSA-9709570 2.074971e-01 0.683 0 0
Impaired BRCA2 binding to PALB2 R-HSA-9709603 2.911270e-01 0.536 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.786184e-01 0.748 0 0
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193 3.075177e-01 0.512 0 0
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192 3.075177e-01 0.512 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331 3.075177e-01 0.512 0 0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646 3.075177e-01 0.512 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 2.424352e-01 0.615 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 3.238324e-01 0.490 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 3.400465e-01 0.468 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 3.561375e-01 0.448 0 0
RET signaling R-HSA-8853659 3.023624e-01 0.519 0 0
Regulation of RAS by GAPs R-HSA-5658442 2.623827e-01 0.581 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 2.305689e-01 0.637 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 3.144707e-01 0.502 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 3.878716e-01 0.411 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 2.635572e-01 0.579 0 0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 4.034800e-01 0.394 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 3.749220e-01 0.426 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 3.401976e-01 0.468 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 3.238324e-01 0.490 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 3.238324e-01 0.490 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 2.582289e-01 0.588 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 2.582289e-01 0.588 0 0
Neutrophil degranulation R-HSA-6798695 1.804459e-01 0.744 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.761976e-01 0.754 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 2.842680e-01 0.546 0 0
Processing of DNA double-strand break ends R-HSA-5693607 3.671235e-01 0.435 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 2.729548e-01 0.564 0 0
G0 and Early G1 R-HSA-1538133 2.424352e-01 0.615 0 0
p75NTR signals via NF-kB R-HSA-193639 2.090797e-01 0.680 0 0
Axonal growth inhibition (RHOA activation) R-HSA-193634 3.885988e-01 0.410 0 0
MAP2K and MAPK activation R-HSA-5674135 3.749220e-01 0.426 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 3.265888e-01 0.486 0 0
Interleukin-15 signaling R-HSA-8983432 1.611240e-01 0.793 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 1.836654e-01 0.736 0 0
Co-inhibition by CTLA4 R-HSA-389513 3.075177e-01 0.512 0 0
Regulation of IFNA/IFNB signaling R-HSA-912694 3.561375e-01 0.448 0 0
DNA Double-Strand Break Repair R-HSA-5693532 3.578763e-01 0.446 0 0
DNA Double Strand Break Response R-HSA-5693606 2.469190e-01 0.607 0 0
Regulation of necroptotic cell death R-HSA-5675482 2.542917e-01 0.595 0 0
Insulin receptor signalling cascade R-HSA-74751 4.018777e-01 0.396 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 1.611240e-01 0.793 0 0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex R-HSA-9931521 2.417838e-01 0.617 0 0
GABA receptor activation R-HSA-977443 1.912287e-01 0.718 0 0
Developmental Cell Lineages R-HSA-9734767 2.048528e-01 0.689 0 0
Long-term potentiation R-HSA-9620244 1.630055e-01 0.788 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 2.074971e-01 0.683 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.408382e-01 0.851 0 0
ADP signalling through P2Y purinoceptor 1 R-HSA-418592 3.878716e-01 0.411 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 3.387045e-01 0.470 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 2.056281e-01 0.687 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.746875e-01 0.561 0 0
TNFR1-mediated ceramide production R-HSA-5626978 2.353392e-01 0.628 0 0
Regulation of FOXO transcriptional activity by acetylation R-HSA-9617629 1.611240e-01 0.793 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 3.606227e-01 0.443 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 3.885988e-01 0.410 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 2.190218e-01 0.660 0 0
HDR through Single Strand Annealing (SSA) R-HSA-5685938 2.542917e-01 0.595 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 3.241032e-01 0.489 0 0
HCMV Early Events R-HSA-9609690 3.683541e-01 0.434 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.556514e-01 0.808 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 2.662273e-01 0.575 0 0
PI5P Regulates TP53 Acetylation R-HSA-6811555 1.769000e-01 0.752 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 3.023624e-01 0.519 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 1.613201e-01 0.792 0 0
SARS-CoV-1-mediated effects on programmed cell death R-HSA-9692913 2.353392e-01 0.628 0 0
RUNX1 regulates transcription of genes involved in interleukin signaling R-HSA-8939247 2.687890e-01 0.571 0 0
Lysosphingolipid and LPA receptors R-HSA-419408 2.090797e-01 0.680 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 2.542917e-01 0.595 0 0
Attenuation phase R-HSA-3371568 3.508059e-01 0.455 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 4.042512e-01 0.393 0 0
Leishmania phagocytosis R-HSA-9664417 4.042512e-01 0.393 0 0
Parasite infection R-HSA-9664407 4.042512e-01 0.393 0 0
Interferon Signaling R-HSA-913531 2.723904e-01 0.565 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 2.335359e-01 0.632 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.989004e-01 0.701 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.787496e-01 0.555 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 2.889625e-01 0.539 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 2.190218e-01 0.660 0 0
Regulation of signaling by CBL R-HSA-912631 2.911270e-01 0.536 0 0
Ovarian tumor domain proteases R-HSA-5689896 3.144707e-01 0.502 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.400465e-01 0.468 0 0
Diseases of DNA Double-Strand Break Repair R-HSA-9675136 2.782271e-01 0.556 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 2.253878e-01 0.647 0 0
Pyroptosis R-HSA-5620971 1.961157e-01 0.707 0 0
Interleukin-9 signaling R-HSA-8985947 3.885988e-01 0.410 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 3.461073e-01 0.461 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.464449e-01 0.834 0 0
Cellular response to heat stress R-HSA-3371556 2.604471e-01 0.584 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.464449e-01 0.834 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 1.603584e-01 0.795 0 0
mRNA Editing: A to I Conversion R-HSA-75064 1.637861e-01 0.786 0 0
C6 deamination of adenosine R-HSA-75102 1.637861e-01 0.786 0 0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5368598 2.003615e-01 0.698 0 0
Activation of BIM and translocation to mitochondria R-HSA-111446 2.003615e-01 0.698 0 0
RUNX1 regulates transcription of genes involved in BCR signaling R-HSA-8939245 2.687890e-01 0.571 0 0
NF-kB is activated and signals survival R-HSA-209560 1.456280e-01 0.837 0 0
Signaling by AXIN mutants R-HSA-4839735 1.456280e-01 0.837 0 0
Signaling by AMER1 mutants R-HSA-4839748 1.456280e-01 0.837 0 0
Regulation of IFNG signaling R-HSA-877312 1.611240e-01 0.793 0 0
Ceramide signalling R-HSA-193681 3.007775e-01 0.522 0 0
Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 3.007775e-01 0.522 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 1.769000e-01 0.752 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 1.769000e-01 0.752 0 0
FGFR1b ligand binding and activation R-HSA-190370 3.885988e-01 0.410 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.961157e-01 0.707 0 0
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 2.746875e-01 0.561 0 0
PKA activation in glucagon signalling R-HSA-164378 2.746875e-01 0.561 0 0
G2/M DNA damage checkpoint R-HSA-69473 1.646582e-01 0.783 0 0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190 2.782271e-01 0.556 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 3.878716e-01 0.411 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 1.603584e-01 0.795 0 0
Acyl chain remodelling of PS R-HSA-1482801 4.034800e-01 0.394 0 0
G2/M Checkpoints R-HSA-69481 3.049031e-01 0.516 0 0
Opioid Signalling R-HSA-111885 2.583828e-01 0.588 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 3.277490e-01 0.484 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 2.665414e-01 0.574 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 1.523725e-01 0.817 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 3.387045e-01 0.470 0 0
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347 3.606227e-01 0.443 0 0
Effects of PIP2 hydrolysis R-HSA-114508 2.662273e-01 0.575 0 0
Hedgehog 'on' state R-HSA-5632684 2.804412e-01 0.552 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 3.885988e-01 0.410 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 2.074971e-01 0.683 0 0
HSF1 activation R-HSA-3371511 3.023624e-01 0.519 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 3.508059e-01 0.455 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 3.508059e-01 0.455 0 0
Diseases of Immune System R-HSA-5260271 3.508059e-01 0.455 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 3.508059e-01 0.455 0 0
Protein-protein interactions at synapses R-HSA-6794362 2.396673e-01 0.620 0 0
Adrenoceptors R-HSA-390696 3.885988e-01 0.410 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 2.746875e-01 0.561 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 2.138379e-01 0.670 0 0
Activation of NOXA and translocation to mitochondria R-HSA-111448 2.353392e-01 0.628 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 1.929018e-01 0.715 0 0
Activation of PUMA and translocation to mitochondria R-HSA-139915 3.606227e-01 0.443 0 0
Activated NTRK3 signals through PI3K R-HSA-9603381 3.606227e-01 0.443 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 3.885988e-01 0.410 0 0
Homologous DNA Pairing and Strand Exchange R-HSA-5693579 3.265888e-01 0.486 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 2.542917e-01 0.595 0 0
Pyruvate metabolism R-HSA-70268 2.617173e-01 0.582 0 0
Interleukin-7 signaling R-HSA-1266695 1.630055e-01 0.788 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.400465e-01 0.468 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.734908e-01 0.761 0 0
Regulation of BACH1 activity R-HSA-9708530 2.253878e-01 0.647 0 0
Meiosis R-HSA-1500620 2.396673e-01 0.620 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 3.918992e-01 0.407 0 0
Interleukin-1 signaling R-HSA-9020702 3.854055e-01 0.414 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 2.417838e-01 0.617 0 0
PKMTs methylate histone lysines R-HSA-3214841 1.699254e-01 0.770 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.928851e-01 0.715 0 0
Negative regulation of MAPK pathway R-HSA-5675221 1.786184e-01 0.748 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 1.374338e-01 0.862 0 0
Diseases of Mismatch Repair (MMR) R-HSA-5423599 2.003615e-01 0.698 0 0
CASP5-mediated substrate cleavage R-HSA-9960525 2.003615e-01 0.698 0 0
p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 2.353392e-01 0.628 0 0
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957 2.353392e-01 0.628 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.687890e-01 0.571 0 0
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes R-HSA-111464 2.687890e-01 0.571 0 0
Signalling to p38 via RIT and RIN R-HSA-187706 3.007775e-01 0.522 0 0
Protein methylation R-HSA-8876725 2.090797e-01 0.680 0 0
LDL remodeling R-HSA-8964041 3.606227e-01 0.443 0 0
Synthesis of PIPs in the nucleus R-HSA-8847453 3.606227e-01 0.443 0 0
TRIF-mediated programmed cell death R-HSA-2562578 3.606227e-01 0.443 0 0
Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 3.885988e-01 0.410 0 0
Neurotransmitter uptake and metabolism In glial cells R-HSA-112313 3.885988e-01 0.410 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.746875e-01 0.561 0 0
Meiotic synapsis R-HSA-1221632 2.918521e-01 0.535 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 2.719711e-01 0.565 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.508059e-01 0.455 0 0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 3.869159e-01 0.412 0 0
Immune System R-HSA-168256 1.972739e-01 0.705 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 1.646742e-01 0.783 0 0
Netrin-1 signaling R-HSA-373752 2.055374e-01 0.687 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 2.042947e-01 0.690 0 0
Integration of energy metabolism R-HSA-163685 1.527517e-01 0.816 0 0
EPHB-mediated forward signaling R-HSA-3928662 2.055374e-01 0.687 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.788405e-01 0.748 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 3.065648e-01 0.513 0 0
SMAC, XIAP-regulated apoptotic response R-HSA-111469 3.007775e-01 0.522 0 0
Intra-Golgi traffic R-HSA-6811438 1.786184e-01 0.748 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 3.461056e-01 0.461 0 0
Diseases of programmed cell death R-HSA-9645723 2.691835e-01 0.570 0 0
MyD88-independent TLR4 cascade R-HSA-166166 3.065648e-01 0.513 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 2.719348e-01 0.566 0 0
Rap1 signalling R-HSA-392517 2.911270e-01 0.536 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 2.542917e-01 0.595 0 0
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 2.902768e-01 0.537 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 2.009388e-01 0.697 0 0
Innate Immune System R-HSA-168249 2.845593e-01 0.546 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 2.181981e-01 0.661 0 0
Toll-like Receptor Cascades R-HSA-168898 3.405789e-01 0.468 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 2.417838e-01 0.617 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 1.738523e-01 0.760 0 0
Cardiac conduction R-HSA-5576891 2.163421e-01 0.665 0 0
Developmental Biology R-HSA-1266738 1.954139e-01 0.709 0 0
Ca-dependent events R-HSA-111996 1.874571e-01 0.727 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 3.818966e-01 0.418 0 0
Stimulation of the cell death response by PAK-2p34 R-HSA-211736 1.637861e-01 0.786 0 0
CASP4-mediated substrate cleavage R-HSA-9960519 2.003615e-01 0.698 0 0
FLT3 signaling through SRC family kinases R-HSA-9706374 2.353392e-01 0.628 0 0
SMAC (DIABLO) binds to IAPs R-HSA-111463 2.687890e-01 0.571 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.687890e-01 0.571 0 0
RUNX2 regulates chondrocyte maturation R-HSA-8941284 2.687890e-01 0.571 0 0
Co-inhibition by BTLA R-HSA-9927353 2.687890e-01 0.571 0 0
Release of apoptotic factors from the mitochondria R-HSA-111457 3.007775e-01 0.522 0 0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis R-HSA-9029558 1.769000e-01 0.752 0 0
Regulation of KIT signaling R-HSA-1433559 1.929018e-01 0.715 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 1.929018e-01 0.715 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 3.606227e-01 0.443 0 0
Phase 3 - rapid repolarisation R-HSA-5576890 3.606227e-01 0.443 0 0
PKA activation R-HSA-163615 2.746875e-01 0.561 0 0
Trafficking of AMPA receptors R-HSA-399719 2.306733e-01 0.637 0 0
Integrin signaling R-HSA-354192 2.542917e-01 0.595 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 3.387045e-01 0.470 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 4.034800e-01 0.394 0 0
TGFBR3 expression R-HSA-9839394 4.034800e-01 0.394 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 3.113923e-01 0.507 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.478714e-01 0.830 0 0
Synthesis of PA R-HSA-1483166 3.317410e-01 0.479 0 0
Signaling by Hippo R-HSA-2028269 2.582289e-01 0.588 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 3.304794e-01 0.481 0 0
Ub-specific processing proteases R-HSA-5689880 3.577292e-01 0.446 0 0
MAP kinase activation R-HSA-450294 1.989004e-01 0.701 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 2.804412e-01 0.552 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 2.542917e-01 0.595 0 0
DAG and IP3 signaling R-HSA-1489509 2.147618e-01 0.668 0 0
Signaling by NTRKs R-HSA-166520 2.138379e-01 0.670 0 0
Formation of the nephric duct R-HSA-9830364 1.630055e-01 0.788 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 1.848950e-01 0.733 0 0
Diseases of DNA repair R-HSA-9675135 2.240975e-01 0.650 0 0
VLDL assembly R-HSA-8866423 3.313684e-01 0.480 0 0
Nef and signal transduction R-HSA-164944 3.313684e-01 0.480 0 0
Syndecan interactions R-HSA-3000170 1.419715e-01 0.848 0 0
Nef Mediated CD4 Down-regulation R-HSA-167590 3.606227e-01 0.443 0 0
Synthesis of PG R-HSA-1483148 2.417838e-01 0.617 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 1.530107e-01 0.815 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 1.699254e-01 0.770 0 0
Interleukin-17 signaling R-HSA-448424 2.719711e-01 0.565 0 0
Intracellular signaling by second messengers R-HSA-9006925 1.986386e-01 0.702 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 2.066296e-01 0.685 0 0
PIP3 activates AKT signaling R-HSA-1257604 3.380993e-01 0.471 0 0
Generic Transcription Pathway R-HSA-212436 3.402644e-01 0.468 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 1.616760e-01 0.791 0 0
Stimuli-sensing channels R-HSA-2672351 2.925977e-01 0.534 0 0
Ephrin signaling R-HSA-3928664 2.746875e-01 0.561 0 0
Signal transduction by L1 R-HSA-445144 3.075177e-01 0.512 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 3.878716e-01 0.411 0 0
Neurodegenerative Diseases R-HSA-8863678 3.878716e-01 0.411 0 0
PI Metabolism R-HSA-1483255 1.381774e-01 0.860 0 0
Calmodulin induced events R-HSA-111933 3.023624e-01 0.519 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 3.496169e-01 0.456 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 2.253878e-01 0.647 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 2.582289e-01 0.588 0 0
CaM pathway R-HSA-111997 3.023624e-01 0.519 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 3.144707e-01 0.502 0 0
Signaling by FGFR1 R-HSA-5654736 3.217278e-01 0.493 0 0
Kidney development R-HSA-9830369 2.469190e-01 0.607 0 0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-8877330 1.769000e-01 0.752 0 0
Signaling by FGFR4 R-HSA-5654743 3.988540e-01 0.399 0 0
Zinc efflux and compartmentalization by the SLC30 family R-HSA-435368 2.687890e-01 0.571 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 3.007775e-01 0.522 0 0
PKA-mediated phosphorylation of CREB R-HSA-111931 3.238324e-01 0.490 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 3.561375e-01 0.448 0 0
NOTCH3 Intracellular Domain Regulates Transcription R-HSA-9013508 2.190218e-01 0.660 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 2.902768e-01 0.537 0 0
Synaptic adhesion-like molecules R-HSA-8849932 2.746875e-01 0.561 0 0
Assembly Of The HIV Virion R-HSA-175474 3.400465e-01 0.468 0 0
Glycogen breakdown (glycogenolysis) R-HSA-70221 4.034800e-01 0.394 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 2.253878e-01 0.647 0 0
Nephron development R-HSA-9831926 2.746875e-01 0.561 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 3.238324e-01 0.490 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 2.542917e-01 0.595 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 3.720853e-01 0.429 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.885988e-01 0.410 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 1.646742e-01 0.783 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 2.782271e-01 0.556 0 0
Interleukin-23 signaling R-HSA-9020933 3.885988e-01 0.410 0 0
XBP1(S) activates chaperone genes R-HSA-381038 2.543069e-01 0.595 0 0
IRE1alpha activates chaperones R-HSA-381070 2.995314e-01 0.524 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.108604e-01 0.386 0 0
Regulated proteolysis of p75NTR R-HSA-193692 4.153524e-01 0.382 0 0
Interleukin-21 signaling R-HSA-9020958 4.153524e-01 0.382 0 0
ALK mutants bind TKIs R-HSA-9700645 4.153524e-01 0.382 0 0
p75NTR regulates axonogenesis R-HSA-193697 4.153524e-01 0.382 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 4.153524e-01 0.382 0 0
Inactivation of CDC42 and RAC1 R-HSA-428543 4.153524e-01 0.382 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 4.153524e-01 0.382 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 4.153524e-01 0.382 0 0
mRNA Editing R-HSA-75072 4.153524e-01 0.382 0 0
ARMS-mediated activation R-HSA-170984 4.153524e-01 0.382 0 0
MAPK1 (ERK2) activation R-HSA-112411 4.153524e-01 0.382 0 0
Regulation of signaling by NODAL R-HSA-1433617 4.153524e-01 0.382 0 0
Regulation of CDH11 gene transcription R-HSA-9762293 4.153524e-01 0.382 0 0
AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 4.153524e-01 0.382 0 0
WNT mediated activation of DVL R-HSA-201688 4.153524e-01 0.382 0 0
GP1b-IX-V activation signalling R-HSA-430116 4.153524e-01 0.382 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 4.153524e-01 0.382 0 0
TCF dependent signaling in response to WNT R-HSA-201681 4.168139e-01 0.380 0 0
Signaling by EGFR in Cancer R-HSA-1643713 4.188960e-01 0.378 0 0
Myogenesis R-HSA-525793 4.188960e-01 0.378 0 0
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769 4.188960e-01 0.378 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 4.188960e-01 0.378 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 4.217398e-01 0.375 0 0
Somitogenesis R-HSA-9824272 4.225269e-01 0.374 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 4.225269e-01 0.374 0 0
Signaling by FGFR3 R-HSA-5654741 4.225269e-01 0.374 0 0
GPCR downstream signalling R-HSA-388396 4.249695e-01 0.372 0 0
Clathrin-mediated endocytosis R-HSA-8856828 4.310069e-01 0.366 0 0
HCMV Infection R-HSA-9609646 4.323687e-01 0.364 0 0
Platelet homeostasis R-HSA-418346 4.325315e-01 0.364 0 0
SARS-CoV-1-host interactions R-HSA-9692914 4.325315e-01 0.364 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 4.341064e-01 0.362 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 4.341064e-01 0.362 0 0
Cristae formation R-HSA-8949613 4.341064e-01 0.362 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 4.341064e-01 0.362 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 4.341064e-01 0.362 0 0
Regulation of pyruvate metabolism R-HSA-9861718 4.342451e-01 0.362 0 0
Signaling by TGFBR3 R-HSA-9839373 4.342451e-01 0.362 0 0
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277 4.409369e-01 0.356 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 4.409369e-01 0.356 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 4.409369e-01 0.356 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 4.409369e-01 0.356 0 0
Ion influx/efflux at host-pathogen interface R-HSA-6803544 4.409369e-01 0.356 0 0
Interleukin-27 signaling R-HSA-9020956 4.409369e-01 0.356 0 0
Defective RIPK1-mediated regulated necrosis R-HSA-9693928 4.409369e-01 0.356 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 4.409369e-01 0.356 0 0
Maturation of spike protein R-HSA-9683686 4.409369e-01 0.356 0 0
MAPK3 (ERK1) activation R-HSA-110056 4.409369e-01 0.356 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 4.409369e-01 0.356 0 0
Josephin domain DUBs R-HSA-5689877 4.409369e-01 0.356 0 0
Tandem pore domain potassium channels R-HSA-1296346 4.409369e-01 0.356 0 0
Receptor Mediated Mitophagy R-HSA-8934903 4.409369e-01 0.356 0 0
Adaptive Immune System R-HSA-1280218 4.443193e-01 0.352 0 0
Activation of kainate receptors upon glutamate binding R-HSA-451326 4.490998e-01 0.348 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 4.509974e-01 0.346 0 0
NGF-stimulated transcription R-HSA-9031628 4.574070e-01 0.340 0 0
Co-stimulation by CD28 R-HSA-389356 4.574070e-01 0.340 0 0
Signaling by Erythropoietin R-HSA-9006335 4.638661e-01 0.334 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 4.638661e-01 0.334 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 4.638661e-01 0.334 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 4.638661e-01 0.334 0 0
RHOBTB3 ATPase cycle R-HSA-9706019 4.654033e-01 0.332 0 0
Presynaptic depolarization and calcium channel opening R-HSA-112308 4.654033e-01 0.332 0 0
Chylomicron assembly R-HSA-8963888 4.654033e-01 0.332 0 0
Synthesis of PIPs at the ER membrane R-HSA-1483248 4.654033e-01 0.332 0 0
PECAM1 interactions R-HSA-210990 4.654033e-01 0.332 0 0
Suppression of apoptosis R-HSA-9635465 4.654033e-01 0.332 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 4.654033e-01 0.332 0 0
Degradation of CDH1 R-HSA-9766229 4.688369e-01 0.329 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 4.688369e-01 0.329 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 4.705935e-01 0.327 0 0
Regulation of mitotic cell cycle R-HSA-453276 4.705935e-01 0.327 0 0
Signaling by GPCR R-HSA-372790 4.743965e-01 0.324 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 4.766541e-01 0.322 0 0
G alpha (s) signalling events R-HSA-418555 4.766541e-01 0.322 0 0
DAP12 signaling R-HSA-2424491 4.783964e-01 0.320 0 0
Activation of the pre-replicative complex R-HSA-68962 4.783964e-01 0.320 0 0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression R-HSA-9933387 4.783964e-01 0.320 0 0
Activation of BH3-only proteins R-HSA-114452 4.783964e-01 0.320 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 4.783964e-01 0.320 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 4.801885e-01 0.319 0 0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 4.881334e-01 0.311 0 0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters R-HSA-9931512 4.888003e-01 0.311 0 0
Sensing of DNA Double Strand Breaks R-HSA-5693548 4.888003e-01 0.311 0 0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 4.888003e-01 0.311 0 0
ERKs are inactivated R-HSA-202670 4.888003e-01 0.311 0 0
Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-113501 4.888003e-01 0.311 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 4.888003e-01 0.311 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.888003e-01 0.311 0 0
Activation of RAC1 R-HSA-428540 4.888003e-01 0.311 0 0
POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 4.888003e-01 0.311 0 0
Cytochrome c-mediated apoptotic response R-HSA-111461 4.888003e-01 0.311 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 4.889957e-01 0.311 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 4.889957e-01 0.311 0 0
Ca2+ pathway R-HSA-4086398 4.897148e-01 0.310 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 4.913635e-01 0.309 0 0
Cargo concentration in the ER R-HSA-5694530 4.926831e-01 0.307 0 0
Budding and maturation of HIV virion R-HSA-162588 4.926831e-01 0.307 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 4.926831e-01 0.307 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 4.933645e-01 0.307 0 0
Adherens junctions interactions R-HSA-418990 4.972732e-01 0.303 0 0
SARS-CoV-1 Infection R-HSA-9678108 5.012631e-01 0.300 0 0
Neurexins and neuroligins R-HSA-6794361 5.024491e-01 0.299 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.024491e-01 0.299 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 5.024491e-01 0.299 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 5.063197e-01 0.296 0 0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276 5.111748e-01 0.291 0 0
GRB2 events in EGFR signaling R-HSA-179812 5.111748e-01 0.291 0 0
Interleukin-35 Signalling R-HSA-8984722 5.111748e-01 0.291 0 0
Role of second messengers in netrin-1 signaling R-HSA-418890 5.111748e-01 0.291 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 5.111748e-01 0.291 0 0
MET activates RAS signaling R-HSA-8851805 5.111748e-01 0.291 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 5.111748e-01 0.291 0 0
NOTCH2 intracellular domain regulates transcription R-HSA-2197563 5.111748e-01 0.291 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 5.111748e-01 0.291 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.134095e-01 0.290 0 0
Interferon alpha/beta signaling R-HSA-909733 5.168666e-01 0.287 0 0
UCH proteinases R-HSA-5689603 5.178434e-01 0.286 0 0
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.205009e-01 0.284 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.205009e-01 0.284 0 0
Activation of ATR in response to replication stress R-HSA-176187 5.205009e-01 0.284 0 0
FGFR1 mutant receptor activation R-HSA-1839124 5.205009e-01 0.284 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 5.205009e-01 0.284 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.205009e-01 0.284 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 5.325712e-01 0.274 0 0
PDH complex synthesizes acetyl-CoA from PYR R-HSA-9861559 5.325712e-01 0.274 0 0
IL-6-type cytokine receptor ligand interactions R-HSA-6788467 5.325712e-01 0.274 0 0
Interleukin-6 signaling R-HSA-1059683 5.325712e-01 0.274 0 0
Frs2-mediated activation R-HSA-170968 5.325712e-01 0.274 0 0
Diseases of nucleotide metabolism R-HSA-9735804 5.325712e-01 0.274 0 0
FGFR1c ligand binding and activation R-HSA-190373 5.325712e-01 0.274 0 0
Formation of axial mesoderm R-HSA-9796292 5.325712e-01 0.274 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.325712e-01 0.274 0 0
Maturation of nucleoprotein R-HSA-9683610 5.325712e-01 0.274 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 5.337630e-01 0.273 0 0
Resolution of D-Loop Structures R-HSA-5693537 5.340219e-01 0.272 0 0
Glucagon signaling in metabolic regulation R-HSA-163359 5.340219e-01 0.272 0 0
Acyl chain remodelling of PC R-HSA-1482788 5.340219e-01 0.272 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 5.340219e-01 0.272 0 0
Vitamin B5 (pantothenate) metabolism R-HSA-199220 5.340219e-01 0.272 0 0
Miscellaneous transport and binding events R-HSA-5223345 5.340219e-01 0.272 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.361860e-01 0.271 0 0
Signaling by FGFR R-HSA-190236 5.375927e-01 0.270 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 5.390605e-01 0.268 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 5.409341e-01 0.267 0 0
Signaling by EGFR R-HSA-177929 5.454961e-01 0.263 0 0
Ion homeostasis R-HSA-5578775 5.454961e-01 0.263 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 5.454961e-01 0.263 0 0
Phospholipid metabolism R-HSA-1483257 5.455931e-01 0.263 0 0
HATs acetylate histones R-HSA-3214847 5.456239e-01 0.263 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 5.472793e-01 0.262 0 0
Signal amplification R-HSA-392518 5.472793e-01 0.262 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 5.472793e-01 0.262 0 0
Signaling by NOTCH2 R-HSA-1980145 5.472793e-01 0.262 0 0
Cell-cell junction organization R-HSA-421270 5.527905e-01 0.257 0 0
Prolactin receptor signaling R-HSA-1170546 5.530324e-01 0.257 0 0
cGMP effects R-HSA-418457 5.530324e-01 0.257 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.530324e-01 0.257 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 5.530324e-01 0.257 0 0
Hydrolysis of LPC R-HSA-1483115 5.530324e-01 0.257 0 0
CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.530324e-01 0.257 0 0
Non-canonical inflammasome activation R-HSA-9686114 5.530324e-01 0.257 0 0
Signal regulatory protein family interactions R-HSA-391160 5.530324e-01 0.257 0 0
Acyl chain remodeling of CL R-HSA-1482798 5.530324e-01 0.257 0 0
Zinc transporters R-HSA-435354 5.530324e-01 0.257 0 0
Platelet activation, signaling and aggregation R-HSA-76002 5.539331e-01 0.257 0 0
Signaling by FGFR2 R-HSA-5654738 5.541721e-01 0.256 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.559142e-01 0.255 0 0
Acyl chain remodelling of PE R-HSA-1482839 5.602701e-01 0.252 0 0
Signalling to ERKs R-HSA-187687 5.602701e-01 0.252 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 5.602701e-01 0.252 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 5.602701e-01 0.252 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 5.614841e-01 0.251 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.661881e-01 0.247 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 5.725991e-01 0.242 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 5.725991e-01 0.242 0 0
Telomere C-strand synthesis initiation R-HSA-174430 5.725991e-01 0.242 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.725991e-01 0.242 0 0
DCC mediated attractive signaling R-HSA-418885 5.725991e-01 0.242 0 0
Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 5.725991e-01 0.242 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 5.725991e-01 0.242 0 0
Signaling by Activin R-HSA-1502540 5.725991e-01 0.242 0 0
Dopamine clearance from the synaptic cleft R-HSA-379401 5.725991e-01 0.242 0 0
Spry regulation of FGF signaling R-HSA-1295596 5.725991e-01 0.242 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 5.725991e-01 0.242 0 0
Biotin transport and metabolism R-HSA-196780 5.725991e-01 0.242 0 0
rRNA processing R-HSA-72312 5.727881e-01 0.242 0 0
G1/S-Specific Transcription R-HSA-69205 5.729924e-01 0.242 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 5.729924e-01 0.242 0 0
RNA Polymerase III Transcription R-HSA-74158 5.729924e-01 0.242 0 0
GPVI-mediated activation cascade R-HSA-114604 5.729924e-01 0.242 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.738054e-01 0.241 0 0
Ion channel transport R-HSA-983712 5.842565e-01 0.233 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.854446e-01 0.233 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 5.854446e-01 0.233 0 0
Regulation of PTEN gene transcription R-HSA-8943724 5.862926e-01 0.232 0 0
Leishmania infection R-HSA-9658195 5.877422e-01 0.231 0 0
Parasitic Infection Pathways R-HSA-9824443 5.877422e-01 0.231 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.913103e-01 0.228 0 0
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 5.913103e-01 0.228 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.913103e-01 0.228 0 0
Prolonged ERK activation events R-HSA-169893 5.913103e-01 0.228 0 0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism R-HSA-9634600 5.913103e-01 0.228 0 0
WNT5:FZD7-mediated leishmania damping R-HSA-9673324 5.913103e-01 0.228 0 0
Killing mechanisms R-HSA-9664420 5.913103e-01 0.228 0 0
Induction of Cell-Cell Fusion R-HSA-9733458 5.913103e-01 0.228 0 0
Negative regulation of FLT3 R-HSA-9706369 5.913103e-01 0.228 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.913103e-01 0.228 0 0
Activation of SMO R-HSA-5635838 5.913103e-01 0.228 0 0
Attachment and Entry R-HSA-9678110 5.913103e-01 0.228 0 0
Hemostasis R-HSA-109582 5.913920e-01 0.228 0 0
RSV-host interactions R-HSA-9833110 5.923418e-01 0.227 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 5.961187e-01 0.225 0 0
Purine salvage R-HSA-74217 5.976262e-01 0.224 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 5.976262e-01 0.224 0 0
RNA Polymerase II Transcription R-HSA-73857 5.981943e-01 0.223 0 0
Asparagine N-linked glycosylation R-HSA-446203 6.043529e-01 0.219 0 0
Mitochondrial protein import R-HSA-1268020 6.057914e-01 0.218 0 0
Heme signaling R-HSA-9707616 6.057914e-01 0.218 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 6.092035e-01 0.215 0 0
mRNA decay by 5' to 3' exoribonuclease R-HSA-430039 6.092035e-01 0.215 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 6.092035e-01 0.215 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 6.092035e-01 0.215 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 6.092035e-01 0.215 0 0
Galactose catabolism R-HSA-70370 6.092035e-01 0.215 0 0
Pentose phosphate pathway R-HSA-71336 6.095369e-01 0.215 0 0
Stabilization of p53 R-HSA-69541 6.095369e-01 0.215 0 0
Activation of gene expression by SREBF (SREBP) R-HSA-2426168 6.153092e-01 0.211 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 6.211770e-01 0.207 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 6.211770e-01 0.207 0 0
Glycogen metabolism R-HSA-8982491 6.211770e-01 0.207 0 0
Antigen processing-Cross presentation R-HSA-1236975 6.219622e-01 0.206 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 6.263143e-01 0.203 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 6.263143e-01 0.203 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 6.263143e-01 0.203 0 0
Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 6.263143e-01 0.203 0 0
Elevation of cytosolic Ca2+ levels R-HSA-139853 6.263143e-01 0.203 0 0
Sulfide oxidation to sulfate R-HSA-1614517 6.263143e-01 0.203 0 0
DNA Repair R-HSA-73894 6.298580e-01 0.201 0 0
Peptide chain elongation R-HSA-156902 6.301938e-01 0.201 0 0
FLT3 Signaling R-HSA-9607240 6.325475e-01 0.199 0 0
Cellular response to hypoxia R-HSA-1234174 6.338749e-01 0.198 0 0
Reproduction R-HSA-1474165 6.360185e-01 0.197 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 6.426769e-01 0.192 0 0
GAB1 signalosome R-HSA-180292 6.426769e-01 0.192 0 0
Mismatch Repair R-HSA-5358508 6.426769e-01 0.192 0 0
FGFR1 ligand binding and activation R-HSA-190242 6.426769e-01 0.192 0 0
Vitamin D (calciferol) metabolism R-HSA-196791 6.426769e-01 0.192 0 0
Polo-like kinase mediated events R-HSA-156711 6.426769e-01 0.192 0 0
Tie2 Signaling R-HSA-210993 6.426769e-01 0.192 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 6.436497e-01 0.191 0 0
Signaling by FGFR1 in disease R-HSA-5655302 6.436497e-01 0.191 0 0
Translation of Structural Proteins R-HSA-9683701 6.436497e-01 0.191 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 6.518084e-01 0.186 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 6.544851e-01 0.184 0 0
Pre-NOTCH Processing in Golgi R-HSA-1912420 6.583240e-01 0.182 0 0
Germ layer formation at gastrulation R-HSA-9754189 6.583240e-01 0.182 0 0
Specification of the neural plate border R-HSA-9834899 6.583240e-01 0.182 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 6.583240e-01 0.182 0 0
Translesion Synthesis by POLH R-HSA-110320 6.583240e-01 0.182 0 0
E2F mediated regulation of DNA replication R-HSA-113510 6.583240e-01 0.182 0 0
Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 6.583240e-01 0.182 0 0
Maturation of nucleoprotein R-HSA-9694631 6.583240e-01 0.182 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 6.605366e-01 0.180 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 6.639000e-01 0.178 0 0
Signaling by WNT R-HSA-195721 6.648119e-01 0.177 0 0
Defective pyroptosis R-HSA-9710421 6.650560e-01 0.177 0 0
Response of Mtb to phagocytosis R-HSA-9637690 6.650560e-01 0.177 0 0
Signaling by SCF-KIT R-HSA-1433557 6.650560e-01 0.177 0 0
Signaling by Insulin receptor R-HSA-74752 6.686513e-01 0.175 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 6.732869e-01 0.172 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 6.732869e-01 0.172 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.732869e-01 0.172 0 0
Signaling by NODAL R-HSA-1181150 6.732869e-01 0.172 0 0
Acyl chain remodelling of PI R-HSA-1482922 6.732869e-01 0.172 0 0
Mitochondrial iron-sulfur cluster biogenesis R-HSA-1362409 6.732869e-01 0.172 0 0
Formation of definitive endoderm R-HSA-9823730 6.732869e-01 0.172 0 0
Nephrin family interactions R-HSA-373753 6.732869e-01 0.172 0 0
Glycogen synthesis R-HSA-3322077 6.732869e-01 0.172 0 0
DAP12 interactions R-HSA-2172127 6.753646e-01 0.170 0 0
COPII-mediated vesicle transport R-HSA-204005 6.775152e-01 0.169 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 6.775152e-01 0.169 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 6.775152e-01 0.169 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.832431e-01 0.165 0 0
Role of phospholipids in phagocytosis R-HSA-2029485 6.836972e-01 0.165 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 6.854136e-01 0.164 0 0
Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.854136e-01 0.164 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 6.854136e-01 0.164 0 0
G-protein activation R-HSA-202040 6.875953e-01 0.163 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 6.875953e-01 0.163 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.875953e-01 0.163 0 0
Signalling to RAS R-HSA-167044 6.875953e-01 0.163 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 6.875953e-01 0.163 0 0
TNFR1-induced proapoptotic signaling R-HSA-5357786 6.875953e-01 0.163 0 0
ERK/MAPK targets R-HSA-198753 6.875953e-01 0.163 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 6.875953e-01 0.163 0 0
Basigin interactions R-HSA-210991 6.875953e-01 0.163 0 0
Acyl chain remodelling of PG R-HSA-1482925 6.875953e-01 0.163 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 6.875953e-01 0.163 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 6.875953e-01 0.163 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 6.894325e-01 0.162 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 6.938576e-01 0.159 0 0
Purine catabolism R-HSA-74259 6.938576e-01 0.159 0 0
Mitochondrial biogenesis R-HSA-1592230 6.964515e-01 0.157 0 0
Rab regulation of trafficking R-HSA-9007101 6.964515e-01 0.157 0 0
Unfolded Protein Response (UPR) R-HSA-381119 6.973369e-01 0.157 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 6.973781e-01 0.157 0 0
Chromatin modifying enzymes R-HSA-3247509 6.988323e-01 0.156 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 7.012779e-01 0.154 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 7.012779e-01 0.154 0 0
Eicosanoids R-HSA-211979 7.012779e-01 0.154 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 7.012779e-01 0.154 0 0
Miscellaneous substrates R-HSA-211958 7.012779e-01 0.154 0 0
Glutathione synthesis and recycling R-HSA-174403 7.012779e-01 0.154 0 0
Attachment and Entry R-HSA-9694614 7.012779e-01 0.154 0 0
Ribavirin ADME R-HSA-9755088 7.012779e-01 0.154 0 0
Extracellular matrix organization R-HSA-1474244 7.024303e-01 0.153 0 0
Homology Directed Repair R-HSA-5693538 7.026946e-01 0.153 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 7.047452e-01 0.152 0 0
Signaling by ERBB4 R-HSA-1236394 7.095672e-01 0.149 0 0
Metal ion SLC transporters R-HSA-425410 7.140342e-01 0.146 0 0
FGFR2 alternative splicing R-HSA-6803529 7.143621e-01 0.146 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 7.143621e-01 0.146 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.143621e-01 0.146 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 7.143621e-01 0.146 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 7.143621e-01 0.146 0 0
Mitotic Prophase R-HSA-68875 7.149117e-01 0.146 0 0
Protein ubiquitination R-HSA-8852135 7.171865e-01 0.144 0 0
Post-translational protein phosphorylation R-HSA-8957275 7.177229e-01 0.144 0 0
Regulation of insulin secretion R-HSA-422356 7.177229e-01 0.144 0 0
G alpha (i) signalling events R-HSA-418594 7.216160e-01 0.142 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 7.230769e-01 0.141 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 7.230769e-01 0.141 0 0
Interleukin-20 family signaling R-HSA-8854691 7.268739e-01 0.139 0 0
Free fatty acids regulate insulin secretion R-HSA-400451 7.268739e-01 0.139 0 0
Fatty acids R-HSA-211935 7.268739e-01 0.139 0 0
Formation of the ureteric bud R-HSA-9830674 7.268739e-01 0.139 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 7.268739e-01 0.139 0 0
PI3K Cascade R-HSA-109704 7.318769e-01 0.136 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 7.319587e-01 0.136 0 0
Formation of the cornified envelope R-HSA-6809371 7.382685e-01 0.132 0 0
Host Interactions of HIV factors R-HSA-162909 7.382685e-01 0.132 0 0
Interleukin-6 family signaling R-HSA-6783589 7.388384e-01 0.131 0 0
Thromboxane signalling through TP receptor R-HSA-428930 7.388384e-01 0.131 0 0
Deadenylation of mRNA R-HSA-429947 7.388384e-01 0.131 0 0
Plasma lipoprotein assembly R-HSA-8963898 7.388384e-01 0.131 0 0
Complex III assembly R-HSA-9865881 7.388384e-01 0.131 0 0
Meiotic recombination R-HSA-912446 7.404382e-01 0.131 0 0
Hedgehog ligand biogenesis R-HSA-5358346 7.404382e-01 0.131 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 7.487647e-01 0.126 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 7.494098e-01 0.125 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 7.494098e-01 0.125 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 7.494098e-01 0.125 0 0
G1/S Transition R-HSA-69206 7.494098e-01 0.125 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 7.496587e-01 0.125 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 7.502795e-01 0.125 0 0
Tight junction interactions R-HSA-420029 7.502795e-01 0.125 0 0
HDMs demethylate histones R-HSA-3214842 7.502795e-01 0.125 0 0
Laminin interactions R-HSA-3000157 7.502795e-01 0.125 0 0
FCGR3A-mediated IL10 synthesis R-HSA-9664323 7.548470e-01 0.122 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 7.553471e-01 0.122 0 0
Regulation of PTEN stability and activity R-HSA-8948751 7.568606e-01 0.121 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 7.596718e-01 0.119 0 0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes R-HSA-9931510 7.612200e-01 0.118 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 7.612200e-01 0.118 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 7.612200e-01 0.118 0 0
Metalloprotease DUBs R-HSA-5689901 7.612200e-01 0.118 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 7.612200e-01 0.118 0 0
Urea cycle R-HSA-70635 7.612200e-01 0.118 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 7.612200e-01 0.118 0 0
Suppression of phagosomal maturation R-HSA-9637687 7.612200e-01 0.118 0 0
Chromatin organization R-HSA-4839726 7.622208e-01 0.118 0 0
Co-inhibition by PD-1 R-HSA-389948 7.622821e-01 0.118 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 7.708904e-01 0.113 0 0
Packaging Of Telomere Ends R-HSA-171306 7.716819e-01 0.113 0 0
Triglyceride biosynthesis R-HSA-75109 7.716819e-01 0.113 0 0
Insulin processing R-HSA-264876 7.716819e-01 0.113 0 0
CD28 dependent PI3K/Akt signaling R-HSA-389357 7.716819e-01 0.113 0 0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-6803204 7.716819e-01 0.113 0 0
Maturation of hRSV A proteins R-HSA-9828806 7.716819e-01 0.113 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 7.723775e-01 0.112 0 0
G alpha (z) signalling events R-HSA-418597 7.723775e-01 0.112 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 7.749180e-01 0.111 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 7.798072e-01 0.108 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 7.802199e-01 0.108 0 0
Telomere Extension By Telomerase R-HSA-171319 7.816860e-01 0.107 0 0
Insulin receptor recycling R-HSA-77387 7.816860e-01 0.107 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.816860e-01 0.107 0 0
PPARA activates gene expression R-HSA-1989781 7.847761e-01 0.105 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 7.850213e-01 0.105 0 0
IRS-mediated signalling R-HSA-112399 7.870234e-01 0.104 0 0
Circadian clock R-HSA-9909396 7.904512e-01 0.102 0 0
Degradation of the extracellular matrix R-HSA-1474228 7.904512e-01 0.102 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.910020e-01 0.102 0 0
Nitric oxide stimulates guanylate cyclase R-HSA-392154 7.912523e-01 0.102 0 0
Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 7.912523e-01 0.102 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 7.912523e-01 0.102 0 0
Platelet calcium homeostasis R-HSA-418360 7.912523e-01 0.102 0 0
DARPP-32 events R-HSA-180024 7.912523e-01 0.102 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 7.936728e-01 0.100 0 0
Gene expression (Transcription) R-HSA-74160 8.003295e-01 0.097 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 8.004000e-01 0.097 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 8.004000e-01 0.097 0 0
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 8.004000e-01 0.097 0 0
Neurotransmitter clearance R-HSA-112311 8.004000e-01 0.097 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 8.004000e-01 0.097 0 0
Extension of Telomeres R-HSA-180786 8.008336e-01 0.096 0 0
Peroxisomal protein import R-HSA-9033241 8.008336e-01 0.096 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 8.008336e-01 0.096 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 8.008336e-01 0.096 0 0
Signaling by TGFB family members R-HSA-9006936 8.064856e-01 0.093 0 0
EGFR downregulation R-HSA-182971 8.091474e-01 0.092 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 8.091474e-01 0.092 0 0
Molecules associated with elastic fibres R-HSA-2129379 8.091474e-01 0.092 0 0
Downstream signal transduction R-HSA-186763 8.091474e-01 0.092 0 0
Peptide ligand-binding receptors R-HSA-375276 8.096683e-01 0.092 0 0
ER-Phagosome pathway R-HSA-1236974 8.135548e-01 0.090 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 8.138435e-01 0.089 0 0
Nucleotide salvage R-HSA-8956321 8.138435e-01 0.089 0 0
Aquaporin-mediated transport R-HSA-445717 8.138435e-01 0.089 0 0
Collagen degradation R-HSA-1442490 8.138435e-01 0.089 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 8.170587e-01 0.088 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 8.175119e-01 0.088 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 8.188196e-01 0.087 0 0
Downstream TCR signaling R-HSA-202424 8.188605e-01 0.087 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 8.200595e-01 0.086 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 8.240372e-01 0.084 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 8.255103e-01 0.083 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 8.255103e-01 0.083 0 0
Cardiogenesis R-HSA-9733709 8.255103e-01 0.083 0 0
Diseases associated with glycosylation precursor biosynthesis R-HSA-5609975 8.255103e-01 0.083 0 0
PTEN Regulation R-HSA-6807070 8.260579e-01 0.083 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 8.260889e-01 0.083 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 8.290871e-01 0.081 0 0
Ion transport by P-type ATPases R-HSA-936837 8.319359e-01 0.080 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 8.331586e-01 0.079 0 0
Heme degradation R-HSA-189483 8.331586e-01 0.079 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 8.340123e-01 0.079 0 0
Nuclear import of Rev protein R-HSA-180746 8.404721e-01 0.075 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 8.404721e-01 0.075 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 8.404721e-01 0.075 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 8.404721e-01 0.075 0 0
Calnexin/calreticulin cycle R-HSA-901042 8.404721e-01 0.075 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 8.404721e-01 0.075 0 0
Phosphate bond hydrolysis by NUDT proteins R-HSA-2393930 8.404721e-01 0.075 0 0
BMAL1:CLOCK,NPAS2 activates circadian expression R-HSA-1368108 8.404721e-01 0.075 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 8.404721e-01 0.075 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 8.431007e-01 0.074 0 0
Collagen formation R-HSA-1474290 8.434971e-01 0.074 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 8.474655e-01 0.072 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 8.480611e-01 0.072 0 0
SLC-mediated transport of amino acids R-HSA-9958863 8.484270e-01 0.071 0 0
Eukaryotic Translation Termination R-HSA-72764 8.525089e-01 0.069 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.525089e-01 0.069 0 0
Chromosome Maintenance R-HSA-73886 8.531103e-01 0.069 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 8.535884e-01 0.069 0 0
PRC2 methylates histones and DNA R-HSA-212300 8.541526e-01 0.068 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 8.541526e-01 0.068 0 0
FLT3 signaling in disease R-HSA-9682385 8.541526e-01 0.068 0 0
Glycosphingolipid transport R-HSA-9845576 8.541526e-01 0.068 0 0
RUNX2 regulates bone development R-HSA-8941326 8.541526e-01 0.068 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 8.568428e-01 0.067 0 0
Leishmania parasite growth and survival R-HSA-9664433 8.582253e-01 0.066 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 8.582253e-01 0.066 0 0
Ubiquinol biosynthesis R-HSA-2142789 8.605470e-01 0.065 0 0
Degradation of DVL R-HSA-4641258 8.605470e-01 0.065 0 0
Cleavage of the damaged purine R-HSA-110331 8.605470e-01 0.065 0 0
Beta-oxidation of very long chain fatty acids R-HSA-390247 8.605470e-01 0.065 0 0
Collagen chain trimerization R-HSA-8948216 8.605470e-01 0.065 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 8.607705e-01 0.065 0 0
Telomere Maintenance R-HSA-157579 8.610649e-01 0.065 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 8.610649e-01 0.065 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 8.634331e-01 0.064 0 0
S Phase R-HSA-69242 8.635003e-01 0.064 0 0
Depurination R-HSA-73927 8.666615e-01 0.062 0 0
alpha-linolenic acid (ALA) metabolism R-HSA-2046106 8.666615e-01 0.062 0 0
Elastic fibre formation R-HSA-1566948 8.666615e-01 0.062 0 0
Gastrulation R-HSA-9758941 8.668433e-01 0.062 0 0
Signaling by ROBO receptors R-HSA-376176 8.668943e-01 0.062 0 0
Metabolism of cofactors R-HSA-8978934 8.681246e-01 0.061 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 8.725082e-01 0.059 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 8.725082e-01 0.059 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.725082e-01 0.059 0 0
RAS processing R-HSA-9648002 8.725082e-01 0.059 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.725082e-01 0.059 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 8.726678e-01 0.059 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 8.726678e-01 0.059 0 0
Selenocysteine synthesis R-HSA-2408557 8.768785e-01 0.057 0 0
Switching of origins to a post-replicative state R-HSA-69052 8.770665e-01 0.057 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 8.780988e-01 0.056 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 8.780988e-01 0.056 0 0
Maturation of TCA enzymes and regulation of TCA cycle R-HSA-9854311 8.780988e-01 0.056 0 0
Platelet degranulation R-HSA-114608 8.784415e-01 0.056 0 0
Protein localization R-HSA-9609507 8.795331e-01 0.056 0 0
Post-translational protein modification R-HSA-597592 8.808483e-01 0.055 0 0
Signaling by FGFR in disease R-HSA-1226099 8.813247e-01 0.055 0 0
ROS and RNS production in phagocytes R-HSA-1222556 8.813247e-01 0.055 0 0
Disease R-HSA-1643685 8.822421e-01 0.054 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 8.834446e-01 0.054 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 8.834446e-01 0.054 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 8.834446e-01 0.054 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 8.834446e-01 0.054 0 0
Maturation of spike protein R-HSA-9694548 8.834446e-01 0.054 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 8.834446e-01 0.054 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 8.834446e-01 0.054 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 8.834446e-01 0.054 0 0
Viral mRNA Translation R-HSA-192823 8.841704e-01 0.053 0 0
ISG15 antiviral mechanism R-HSA-1169408 8.854462e-01 0.053 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 8.876701e-01 0.052 0 0
ESR-mediated signaling R-HSA-8939211 8.877156e-01 0.052 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.885564e-01 0.051 0 0
Translation of Structural Proteins R-HSA-9694635 8.932943e-01 0.049 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 8.934442e-01 0.049 0 0
MTOR signalling R-HSA-165159 8.934442e-01 0.049 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.934442e-01 0.049 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 8.934442e-01 0.049 0 0
Depyrimidination R-HSA-73928 8.934442e-01 0.049 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 8.981179e-01 0.047 0 0
SARS-CoV Infections R-HSA-9679506 8.991923e-01 0.046 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 8.998989e-01 0.046 0 0
Developmental Lineage of Pancreatic Acinar Cells R-HSA-9925561 9.006403e-01 0.045 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 9.007414e-01 0.045 0 0
Viral Infection Pathways R-HSA-9824446 9.021538e-01 0.045 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 9.025869e-01 0.045 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 9.025869e-01 0.045 0 0
Amine ligand-binding receptors R-HSA-375280 9.025869e-01 0.045 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 9.037876e-01 0.044 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 9.037876e-01 0.044 0 0
Nucleosome assembly R-HSA-774815 9.068601e-01 0.042 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 9.068601e-01 0.042 0 0
Fanconi Anemia Pathway R-HSA-6783310 9.068601e-01 0.042 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 9.068601e-01 0.042 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 9.068601e-01 0.042 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 9.068601e-01 0.042 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 9.068601e-01 0.042 0 0
Degradation of cysteine and homocysteine R-HSA-1614558 9.068601e-01 0.042 0 0
TCR signaling R-HSA-202403 9.096278e-01 0.041 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 9.106003e-01 0.041 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 9.109462e-01 0.041 0 0
Neddylation R-HSA-8951664 9.133111e-01 0.039 0 0
Cytoprotection by HMOX1 R-HSA-9707564 9.139382e-01 0.039 0 0
mRNA Splicing - Major Pathway R-HSA-72163 9.140394e-01 0.039 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.148532e-01 0.039 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 9.148532e-01 0.039 0 0
Synthesis of PC R-HSA-1483191 9.148532e-01 0.039 0 0
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism R-HSA-2046104 9.148532e-01 0.039 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 9.151448e-01 0.039 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 9.151448e-01 0.039 0 0
Ribosome-associated quality control R-HSA-9948299 9.155599e-01 0.038 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 9.169918e-01 0.038 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 9.169918e-01 0.038 0 0
Plasma lipoprotein remodeling R-HSA-8963899 9.185890e-01 0.037 0 0
DNA Damage Bypass R-HSA-73893 9.221612e-01 0.035 0 0
HIV Infection R-HSA-162906 9.247330e-01 0.034 0 0
SARS-CoV-2-host interactions R-HSA-9705683 9.265037e-01 0.033 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.276209e-01 0.033 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 9.288427e-01 0.032 0 0
Eukaryotic Translation Initiation R-HSA-72613 9.299048e-01 0.032 0 0
Cap-dependent Translation Initiation R-HSA-72737 9.299048e-01 0.032 0 0
Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 9.307896e-01 0.031 0 0
FCERI mediated NF-kB activation R-HSA-2871837 9.310390e-01 0.031 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.314003e-01 0.031 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 9.319655e-01 0.031 0 0
mRNA 3'-end processing R-HSA-72187 9.319655e-01 0.031 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 9.319655e-01 0.031 0 0
Orc1 removal from chromatin R-HSA-68949 9.319655e-01 0.031 0 0
mRNA Splicing R-HSA-72172 9.348098e-01 0.029 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 9.349514e-01 0.029 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 9.349514e-01 0.029 0 0
Nucleotide biosynthesis R-HSA-8956320 9.349514e-01 0.029 0 0
Base Excision Repair R-HSA-73884 9.356771e-01 0.029 0 0
Neurotransmitter release cycle R-HSA-112310 9.356771e-01 0.029 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 9.363648e-01 0.029 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 9.378065e-01 0.028 0 0
Metabolism of nucleotides R-HSA-15869 9.394070e-01 0.027 0 0
SARS-CoV-2 Infection R-HSA-9694516 9.401907e-01 0.027 0 0
Potential therapeutics for SARS R-HSA-9679191 9.422147e-01 0.026 0 0
MITF-M-dependent gene expression R-HSA-9856651 9.422147e-01 0.026 0 0
FCGR activation R-HSA-2029481 9.444875e-01 0.025 0 0
Dectin-2 family R-HSA-5621480 9.456425e-01 0.024 0 0
Mitochondrial protein degradation R-HSA-9837999 9.465037e-01 0.024 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.480289e-01 0.023 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.480289e-01 0.023 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 9.487756e-01 0.023 0 0
Triglyceride metabolism R-HSA-8979227 9.503106e-01 0.022 0 0
Amino acid transport across the plasma membrane R-HSA-352230 9.503106e-01 0.022 0 0
RAB geranylgeranylation R-HSA-8873719 9.524924e-01 0.021 0 0
tRNA Aminoacylation R-HSA-379724 9.524924e-01 0.021 0 0
Glutathione conjugation R-HSA-156590 9.524924e-01 0.021 0 0
Signaling by Retinoic Acid R-HSA-5362517 9.524924e-01 0.021 0 0
Cellular response to starvation R-HSA-9711097 9.545488e-01 0.020 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 9.545784e-01 0.020 0 0
Signaling by Nuclear Receptors R-HSA-9006931 9.555212e-01 0.020 0 0
Nucleotide catabolism R-HSA-8956319 9.556275e-01 0.020 0 0
Interferon gamma signaling R-HSA-877300 9.559074e-01 0.020 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 9.565730e-01 0.019 0 0
tRNA processing in the nucleus R-HSA-6784531 9.565730e-01 0.019 0 0
Signaling by PDGF R-HSA-186797 9.565730e-01 0.019 0 0
Complex I biogenesis R-HSA-6799198 9.584801e-01 0.018 0 0
Glycolysis R-HSA-70171 9.587825e-01 0.018 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.592544e-01 0.018 0 0
CD22 mediated BCR regulation R-HSA-5690714 9.603036e-01 0.018 0 0
Regulation of endogenous retroelements R-HSA-9842860 9.617624e-01 0.017 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 9.617624e-01 0.017 0 0
Selenoamino acid metabolism R-HSA-2408522 9.621552e-01 0.017 0 0
Nicotinate metabolism R-HSA-196807 9.653080e-01 0.015 0 0
Activation of HOX genes during differentiation R-HSA-5619507 9.658479e-01 0.015 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 9.658479e-01 0.015 0 0
Nucleotide Excision Repair R-HSA-5696398 9.671139e-01 0.015 0 0
Estrogen-dependent gene expression R-HSA-9018519 9.671761e-01 0.014 0 0
Synthesis of DNA R-HSA-69239 9.695119e-01 0.013 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 9.696823e-01 0.013 0 0
Epigenetic regulation of gene expression R-HSA-212165 9.698920e-01 0.013 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 9.710143e-01 0.013 0 0
ECM proteoglycans R-HSA-3000178 9.710143e-01 0.013 0 0
Diseases associated with O-glycosylation of proteins R-HSA-3906995 9.710143e-01 0.013 0 0
Metabolism of porphyrins R-HSA-189445 9.710143e-01 0.013 0 0
DNA Replication Pre-Initiation R-HSA-69002 9.717411e-01 0.012 0 0
Keratinization R-HSA-6805567 9.734295e-01 0.012 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 9.735057e-01 0.012 0 0
Transport of vitamins, nucleosides, and related molecules R-HSA-425397 9.746700e-01 0.011 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.747926e-01 0.011 0 0
Inositol phosphate metabolism R-HSA-1483249 9.747926e-01 0.011 0 0
Citric acid cycle (TCA cycle) R-HSA-71403 9.757832e-01 0.011 0 0
TP53 Regulates Transcription of Cell Death Genes R-HSA-5633008 9.757832e-01 0.011 0 0
Influenza Infection R-HSA-168255 9.770510e-01 0.010 0 0
Interleukin-10 signaling R-HSA-6783783 9.788381e-01 0.009 0 0
ABC transporter disorders R-HSA-5619084 9.788381e-01 0.009 0 0
Integrin cell surface interactions R-HSA-216083 9.788381e-01 0.009 0 0
Metabolic disorders of biological oxidation enzymes R-HSA-5579029 9.797683e-01 0.009 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 9.806571e-01 0.008 0 0
Signaling by MET R-HSA-6806834 9.806577e-01 0.008 0 0
Glucose metabolism R-HSA-70326 9.807252e-01 0.008 0 0
Peptide hormone metabolism R-HSA-2980736 9.807252e-01 0.008 0 0
Amyloid fiber formation R-HSA-977225 9.815081e-01 0.008 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 9.816839e-01 0.008 0 0
Arachidonate metabolism R-HSA-2142753 9.816839e-01 0.008 0 0
DNA Replication R-HSA-69306 9.823110e-01 0.008 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 9.823211e-01 0.008 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 9.823211e-01 0.008 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 9.830984e-01 0.007 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 9.834819e-01 0.007 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 9.835041e-01 0.007 0 0
Peroxisomal lipid metabolism R-HSA-390918 9.838416e-01 0.007 0 0
HCMV Late Events R-HSA-9610379 9.846200e-01 0.007 0 0
Sensory perception of sweet, bitter, and umami (glutamate) taste R-HSA-9717207 9.847127e-01 0.007 0 0
Sulfur amino acid metabolism R-HSA-1614635 9.858810e-01 0.006 0 0
Infectious disease R-HSA-5663205 9.877651e-01 0.005 0 0
Class B/2 (Secretin family receptors) R-HSA-373080 9.882060e-01 0.005 0 0
SLC transporter disorders R-HSA-5619102 9.891974e-01 0.005 0 0
Sensory perception of taste R-HSA-9717189 9.896458e-01 0.005 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 9.896952e-01 0.004 0 0
Assembly of the pre-replicative complex R-HSA-68867 9.901486e-01 0.004 0 0
tRNA processing R-HSA-72306 9.906338e-01 0.004 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.920001e-01 0.003 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 9.926912e-01 0.003 0 0
ABC-family proteins mediated transport R-HSA-382556 9.931276e-01 0.003 0 0
Late Phase of HIV Life Cycle R-HSA-162599 9.937953e-01 0.003 0 0
Antimicrobial peptides R-HSA-6803157 9.959970e-01 0.002 0 0
GPCR ligand binding R-HSA-500792 9.965102e-01 0.002 0 0
HIV Life Cycle R-HSA-162587 9.965872e-01 0.001 0 0
Cell surface interactions at the vascular wall R-HSA-202733 9.967853e-01 0.001 0 0
Metabolism of RNA R-HSA-8953854 9.974588e-01 0.001 0 0
Disorders of transmembrane transporters R-HSA-5619115 9.977313e-01 0.001 0 0
Metabolism of steroids R-HSA-8957322 9.980210e-01 0.001 0 0
Regulation of Complement cascade R-HSA-977606 9.980540e-01 0.001 0 0
Translation R-HSA-72766 9.982645e-01 0.001 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.983240e-01 0.001 0 0
Transport of small molecules R-HSA-382551 9.987319e-01 0.001 0 0
Metabolism of proteins R-HSA-392499 9.988019e-01 0.001 0 0
Diseases of glycosylation R-HSA-3781865 9.989002e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.990176e-01 0.000 0 0
Complement cascade R-HSA-166658 9.993413e-01 0.000 0 0
Cytochrome P450 - arranged by substrate type R-HSA-211897 9.997563e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.998351e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.998572e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.998584e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.999712e-01 0.000 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 9.999779e-01 0.000 0 0
Drug ADME R-HSA-9748784 9.999779e-01 0.000 0 0
Bacterial Infection Pathways R-HSA-9824439 9.999892e-01 0.000 0 0
Phase II - Conjugation of compounds R-HSA-156580 9.999915e-01 0.000 0 0
Diseases of metabolism R-HSA-5668914 9.999975e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.999986e-01 0.000 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Biological oxidations R-HSA-211859 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 -0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways
Motif of predicted substrate sequence
Reactome pathways of predicted substrates
Download
name reactome_id p -log10p ref_path ref_path_lowest
Aggrephagy R-HSA-9646399 1.110223e-16 15.955 0 0
HSF1 activation R-HSA-3371511 1.110223e-16 15.955 0 0
Attenuation phase R-HSA-3371568 1.110223e-16 15.955 0 0
HSF1-dependent transactivation R-HSA-3371571 1.110223e-16 15.955 0 0
Cellular response to heat stress R-HSA-3371556 1.110223e-16 15.955 0 0
Regulation of HSF1-mediated heat shock response R-HSA-3371453 1.110223e-16 15.955 0 0
M Phase R-HSA-68886 1.110223e-16 15.955 0 0
Axon guidance R-HSA-422475 1.110223e-16 15.955 0 0
Nervous system development R-HSA-9675108 1.110223e-16 15.955 0 0
Cellular responses to stimuli R-HSA-8953897 1.110223e-16 15.955 0 0
Cellular responses to stress R-HSA-2262752 1.110223e-16 15.955 0 0
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 3.330669e-16 15.477 0 0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-3371497 1.887379e-15 14.724 0 0
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 2.442491e-15 14.612 0 0
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148 7.216450e-15 14.142 0 0
Eukaryotic Translation Initiation R-HSA-72613 1.465494e-14 13.834 0 0
Cap-dependent Translation Initiation R-HSA-72737 1.465494e-14 13.834 0 0
Eukaryotic Translation Elongation R-HSA-156842 1.709743e-14 13.767 0 0
Metabolism of RNA R-HSA-8953854 1.720846e-14 13.764 0 0
Cell Cycle, Mitotic R-HSA-69278 5.373479e-14 13.270 0 0
Cell Cycle R-HSA-1640170 1.022515e-13 12.990 0 0
Mitotic Anaphase R-HSA-68882 1.517675e-13 12.819 0 0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 1.521006e-13 12.818 0 0
Mitotic Metaphase and Anaphase R-HSA-2555396 1.717515e-13 12.765 0 0
Transport of connexons to the plasma membrane R-HSA-190872 2.743361e-13 12.562 0 0
PKR-mediated signaling R-HSA-9833482 3.377298e-13 12.471 0 0
Cytokine Signaling in Immune system R-HSA-1280215 3.850253e-13 12.415 0 0
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736 5.195844e-13 12.284 0 0
Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 6.240564e-13 12.205 0 0
GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 6.495915e-13 12.187 0 0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389958 9.222623e-13 12.035 0 0
Ribosome-associated quality control R-HSA-9948299 1.062261e-12 11.974 0 0
Cell-Cell communication R-HSA-1500931 1.265210e-12 11.898 0 0
G2/M Transition R-HSA-69275 1.606715e-12 11.794 0 0
Mitotic G2-G2/M phases R-HSA-453274 2.073564e-12 11.683 0 0
Peptide chain elongation R-HSA-156902 2.363887e-12 11.626 0 0
Nuclear Envelope (NE) Reassembly R-HSA-2995410 2.587153e-12 11.587 0 0
SARS-CoV-1-host interactions R-HSA-9692914 2.904565e-12 11.537 0 0
Influenza Infection R-HSA-168255 3.174350e-12 11.498 0 0
Recycling pathway of L1 R-HSA-437239 3.419043e-12 11.466 0 0
Activation of AMPK downstream of NMDARs R-HSA-9619483 3.584133e-12 11.446 0 0
L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 4.141687e-12 11.383 0 0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 5.254686e-12 11.279 0 0
Separation of Sister Chromatids R-HSA-2467813 9.494405e-12 11.023 0 0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA R-HSA-9954716 1.126643e-11 10.948 0 0
Viral Infection Pathways R-HSA-9824446 1.169831e-11 10.932 0 0
Post-chaperonin tubulin folding pathway R-HSA-389977 1.337075e-11 10.874 0 0
Influenza Viral RNA Transcription and Replication R-HSA-168273 1.427081e-11 10.846 0 0
Recruitment of NuMA to mitotic centrosomes R-HSA-380320 1.642952e-11 10.784 0 0
Selective autophagy R-HSA-9663891 1.642952e-11 10.784 0 0
SRP-dependent cotranslational protein targeting to membrane R-HSA-1799339 2.143508e-11 10.669 0 0
Nonsense-Mediated Decay (NMD) R-HSA-927802 4.888712e-11 10.311 0 0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 4.888712e-11 10.311 0 0
Regulation of expression of SLITs and ROBOs R-HSA-9010553 4.775969e-11 10.321 0 0
Mitotic Prometaphase R-HSA-68877 8.001311e-11 10.097 0 0
Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 8.096335e-11 10.092 0 0
Formation of a pool of free 40S subunits R-HSA-72689 8.626544e-11 10.064 0 0
Translation R-HSA-72766 1.040027e-10 9.983 0 0
Interferon Signaling R-HSA-913531 1.170639e-10 9.932 0 0
Cell junction organization R-HSA-446728 1.124616e-10 9.949 0 0
Gap junction trafficking R-HSA-190828 1.314031e-10 9.881 0 0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA R-HSA-9954714 1.875607e-10 9.727 0 0
Apoptotic execution phase R-HSA-75153 2.252807e-10 9.647 0 0
Sealing of the nuclear envelope (NE) by ESCRT-III R-HSA-9668328 2.660204e-10 9.575 0 0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 3.112275e-10 9.507 0 0
Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9633012 3.863221e-10 9.413 0 0
Regulation of CDH1 Function R-HSA-9764561 4.028212e-10 9.395 0 0
Interleukin-12 signaling R-HSA-9020591 4.126722e-10 9.384 0 0
HCMV Early Events R-HSA-9609690 4.786671e-10 9.320 0 0
Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 4.985481e-10 9.302 0 0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72662 5.055285e-10 9.296 0 0
Gap junction trafficking and regulation R-HSA-157858 4.855538e-10 9.314 0 0
Gap junction assembly R-HSA-190861 5.023458e-10 9.299 0 0
Eukaryotic Translation Termination R-HSA-72764 5.243571e-10 9.280 0 0
Post NMDA receptor activation events R-HSA-438064 5.801104e-10 9.236 0 0
L1CAM interactions R-HSA-373760 6.771805e-10 9.169 0 0
rRNA processing in the nucleus and cytosol R-HSA-8868773 8.542572e-10 9.068 0 0
Signaling by ROBO receptors R-HSA-376176 9.956114e-10 9.002 0 0
Resolution of Sister Chromatid Cohesion R-HSA-2500257 1.370316e-09 8.863 0 0
Selenocysteine synthesis R-HSA-2408557 1.370445e-09 8.863 0 0
Translation initiation complex formation R-HSA-72649 1.585705e-09 8.800 0 0
Viral mRNA Translation R-HSA-192823 1.862011e-09 8.730 0 0
COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 1.983128e-09 8.703 0 0
Ribosomal scanning and start codon recognition R-HSA-72702 2.470184e-09 8.607 0 0
Apoptosis R-HSA-109581 3.463521e-09 8.460 0 0
Interleukin-12 family signaling R-HSA-447115 3.531603e-09 8.452 0 0
SARS-CoV-1 modulates host translation machinery R-HSA-9735869 4.966128e-09 8.304 0 0
EML4 and NUDC in mitotic spindle formation R-HSA-9648025 5.181181e-09 8.286 0 0
Autophagy R-HSA-9612973 7.678777e-09 8.115 0 0
Developmental Lineage of Mammary Gland Myoepithelial Cells R-HSA-9927432 8.263761e-09 8.083 0 0
Activation of NMDA receptors and postsynaptic events R-HSA-442755 8.696234e-09 8.061 0 0
SARS-CoV-1 Infection R-HSA-9678108 1.536950e-08 7.813 0 0
Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 1.956202e-08 7.709 0 0
Chaperonin-mediated protein folding R-HSA-390466 2.040973e-08 7.690 0 0
HCMV Infection R-HSA-9609646 2.165644e-08 7.664 0 0
Macroautophagy R-HSA-1632852 2.412123e-08 7.618 0 0
Cell-extracellular matrix interactions R-HSA-446353 4.139774e-08 7.383 0 0
Kinesins R-HSA-983189 3.917539e-08 7.407 0 0
SARS-CoV-2-host interactions R-HSA-9705683 4.221821e-08 7.375 0 0
Cargo trafficking to the periciliary membrane R-HSA-5620920 4.418195e-08 7.355 0 0
Protein folding R-HSA-391251 5.003034e-08 7.301 0 0
rRNA processing R-HSA-72312 5.891644e-08 7.230 0 0
Programmed Cell Death R-HSA-5357801 7.446509e-08 7.128 0 0
SARS-CoV-2 modulates host translation machinery R-HSA-9754678 8.357889e-08 7.078 0 0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide R-HSA-9954709 8.782242e-08 7.056 0 0
Developmental Biology R-HSA-1266738 1.085142e-07 6.965 0 0
Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72695 1.174986e-07 6.930 0 0
Cellular response to starvation R-HSA-9711097 1.604024e-07 6.795 0 0
Hedgehog 'off' state R-HSA-5610787 1.712075e-07 6.766 0 0
Regulation of CDH1 Expression and Function R-HSA-9764265 1.915915e-07 6.718 0 0
Regulation of Expression and Function of Type I Classical Cadherins R-HSA-9764274 1.915915e-07 6.718 0 0
Chaperone Mediated Autophagy R-HSA-9613829 2.038930e-07 6.691 0 0
Infectious disease R-HSA-5663205 2.985220e-07 6.525 0 0
Selenoamino acid metabolism R-HSA-2408522 2.851937e-07 6.545 0 0
Striated Muscle Contraction R-HSA-390522 3.034568e-07 6.518 0 0
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 3.322751e-07 6.479 0 0
Apoptosis induced DNA fragmentation R-HSA-140342 5.751238e-07 6.240 0 0
Mitotic Prophase R-HSA-68875 5.805914e-07 6.236 0 0
Cell-cell junction organization R-HSA-421270 8.244832e-07 6.084 0 0
Cilium Assembly R-HSA-5617833 8.432108e-07 6.074 0 0
Host Interactions of HIV factors R-HSA-162909 8.917483e-07 6.050 0 0
Intraflagellar transport R-HSA-5620924 1.190960e-06 5.924 0 0
Signaling by Hedgehog R-HSA-5358351 1.234587e-06 5.908 0 0
Cellular Senescence R-HSA-2559583 1.278237e-06 5.893 0 0
Regulation of Homotypic Cell-Cell Adhesion R-HSA-9759476 1.367794e-06 5.864 0 0
Developmental Lineages of the Mammary Gland R-HSA-9924644 1.663381e-06 5.779 0 0
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 1.663381e-06 5.779 0 0
Signaling by Interleukins R-HSA-449147 1.877408e-06 5.726 0 0
COPI-mediated anterograde transport R-HSA-6807878 2.295938e-06 5.639 0 0
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202 2.345558e-06 5.630 0 0
Adherens junctions interactions R-HSA-418990 2.393327e-06 5.621 0 0
Response to elevated platelet cytosolic Ca2+ R-HSA-76005 2.680568e-06 5.572 0 0
Metalloprotease DUBs R-HSA-5689901 3.007275e-06 5.522 0 0
UCH proteinases R-HSA-5689603 2.897175e-06 5.538 0 0
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 4.527287e-06 5.344 0 0
Muscle contraction R-HSA-397014 4.882975e-06 5.311 0 0
Platelet degranulation R-HSA-114608 5.285480e-06 5.277 0 0
Signaling by RAS mutants R-HSA-6802949 5.288687e-06 5.277 0 0
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 5.288687e-06 5.277 0 0
Signaling downstream of RAS mutants R-HSA-9649948 5.288687e-06 5.277 0 0
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 5.288687e-06 5.277 0 0
Nuclear Envelope Breakdown R-HSA-2980766 5.349931e-06 5.272 0 0
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 5.583317e-06 5.253 0 0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.583317e-06 5.253 0 0
FLT3 signaling by CBL mutants R-HSA-9706377 6.341455e-06 5.198 0 0
Transcriptional regulation by small RNAs R-HSA-5578749 8.478864e-06 5.072 0 0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-428359 8.879627e-06 5.052 0 0
Developmental Cell Lineages of the Integumentary System R-HSA-9734779 9.460933e-06 5.024 0 0
COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 1.003084e-05 4.999 0 0
Apoptotic cleavage of cellular proteins R-HSA-111465 1.171432e-05 4.931 0 0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446388 1.200832e-05 4.921 0 0
MHC class II antigen presentation R-HSA-2132295 1.254460e-05 4.902 0 0
Signaling by RAF1 mutants R-HSA-9656223 1.384672e-05 4.859 0 0
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 1.488867e-05 4.827 0 0
Signaling by BRAF and RAF1 fusions R-HSA-6802952 1.671092e-05 4.777 0 0
Oxidative Stress Induced Senescence R-HSA-2559580 1.875772e-05 4.727 0 0
Signaling by EGFR in Cancer R-HSA-1643713 2.443645e-05 4.612 0 0
Mitochondrial unfolded protein response (UPRmt) R-HSA-9841251 3.031035e-05 4.518 0 0
Factors involved in megakaryocyte development and platelet production R-HSA-983231 3.103027e-05 4.508 0 0
Golgi-to-ER retrograde transport R-HSA-8856688 3.271488e-05 4.485 0 0
SARS-CoV-2 Infection R-HSA-9694516 3.404126e-05 4.468 0 0
Regulation of PTEN localization R-HSA-8948747 3.457255e-05 4.461 0 0
Immune System R-HSA-168256 3.835258e-05 4.416 0 0
Formation of Senescence-Associated Heterochromatin Foci (SAHF) R-HSA-2559584 3.940614e-05 4.404 0 0
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 4.517180e-05 4.345 0 0
Degradation of CDH1 R-HSA-9766229 4.890196e-05 4.311 0 0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8849469 5.408295e-05 4.267 0 0
Downregulation of ERBB2 signaling R-HSA-8863795 5.544418e-05 4.256 0 0
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.545596e-05 4.256 0 0
Centrosome maturation R-HSA-380287 5.681907e-05 4.246 0 0
ISG15 antiviral mechanism R-HSA-1169408 5.681907e-05 4.246 0 0
Transmission across Chemical Synapses R-HSA-112315 5.764571e-05 4.239 0 0
SARS-CoV Infections R-HSA-9679506 6.015835e-05 4.221 0 0
Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 6.262711e-05 4.203 0 0
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 6.281214e-05 4.202 0 0
Loss of Nlp from mitotic centrosomes R-HSA-380259 6.281214e-05 4.202 0 0
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927 6.281214e-05 4.202 0 0
Signaling by PTK6 R-HSA-8848021 6.281214e-05 4.202 0 0
Metabolism of proteins R-HSA-392499 6.657322e-05 4.177 0 0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 7.236186e-05 4.140 0 0
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507 7.837217e-05 4.106 0 0
AURKA Activation by TPX2 R-HSA-8854518 9.010889e-05 4.045 0 0
Ub-specific processing proteases R-HSA-5689880 8.248872e-05 4.084 0 0
Smooth Muscle Contraction R-HSA-445355 8.502902e-05 4.070 0 0
Regulation of MECP2 expression and activity R-HSA-9022692 9.593119e-05 4.018 0 0
Processing of Capped Intron-Containing Pre-mRNA R-HSA-72203 9.855977e-05 4.006 0 0
HIV Infection R-HSA-162906 1.061567e-04 3.974 0 0
TGF-beta receptor signaling activates SMADs R-HSA-2173789 1.105387e-04 3.956 0 0
Josephin domain DUBs R-HSA-5689877 1.176460e-04 3.929 0 0
Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 1.195651e-04 3.922 0 0
Organelle biogenesis and maintenance R-HSA-1852241 1.212278e-04 3.916 0 0
Signaling by ALK fusions and activated point mutants R-HSA-9725370 1.241925e-04 3.906 0 0
Signaling by ALK in cancer R-HSA-9700206 1.241925e-04 3.906 0 0
Gene Silencing by RNA R-HSA-211000 1.241925e-04 3.906 0 0
Signaling by EGFR R-HSA-177929 1.251353e-04 3.903 0 0
Nuclear import of Rev protein R-HSA-180746 1.346109e-04 3.871 0 0
Neutrophil degranulation R-HSA-6798695 1.376850e-04 3.861 0 0
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 1.417964e-04 3.848 0 0
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 1.470472e-04 3.833 0 0
Oncogenic MAPK signaling R-HSA-6802957 1.622130e-04 3.790 0 0
Membrane Trafficking R-HSA-199991 1.739558e-04 3.760 0 0
Regulation of TP53 Degradation R-HSA-6804757 1.853304e-04 3.732 0 0
Depolymerization of the Nuclear Lamina R-HSA-4419969 2.021589e-04 3.694 0 0
HIV Life Cycle R-HSA-162587 2.371387e-04 3.625 0 0
Ovarian tumor domain proteases R-HSA-5689896 2.160350e-04 3.665 0 0
Signaling by high-kinase activity BRAF mutants R-HSA-6802948 2.160350e-04 3.665 0 0
Cell Cycle Checkpoints R-HSA-69620 2.142892e-04 3.669 0 0
Glycolysis R-HSA-70171 2.235658e-04 3.651 0 0
Signaling by NOTCH4 R-HSA-9013694 2.167908e-04 3.664 0 0
Maturation of protein E R-HSA-9683683 2.147577e-04 3.668 0 0
Maturation of protein E R-HSA-9694493 2.147577e-04 3.668 0 0
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580 2.498211e-04 3.602 0 0
p53-Dependent G1 DNA Damage Response R-HSA-69563 2.498211e-04 3.602 0 0
Regulation of signaling by CBL R-HSA-912631 2.533373e-04 3.596 0 0
APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 2.533373e-04 3.596 0 0
Translesion Synthesis by POLH R-HSA-110320 2.533373e-04 3.596 0 0
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 2.542706e-04 3.595 0 0
Developmental Cell Lineages R-HSA-9734767 2.745810e-04 3.561 0 0
Semaphorin interactions R-HSA-373755 2.840338e-04 3.547 0 0
Regulation of TP53 Expression and Degradation R-HSA-6806003 2.899948e-04 3.538 0 0
Stabilization of p53 R-HSA-69541 2.899948e-04 3.538 0 0
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 3.045700e-04 3.516 0 0
p75NTR recruits signalling complexes R-HSA-209543 3.045700e-04 3.516 0 0
Hedgehog ligand biogenesis R-HSA-5358346 3.203226e-04 3.494 0 0
Interactions of Rev with host cellular proteins R-HSA-177243 3.340656e-04 3.476 0 0
Negative regulation of NOTCH4 signaling R-HSA-9604323 3.340656e-04 3.476 0 0
Regulation of RUNX3 expression and activity R-HSA-8941858 3.340656e-04 3.476 0 0
Disease R-HSA-1643685 3.360788e-04 3.474 0 0
E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 3.613021e-04 3.442 0 0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 3.613021e-04 3.442 0 0
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916 3.613021e-04 3.442 0 0
ER to Golgi Anterograde Transport R-HSA-199977 3.646010e-04 3.438 0 0
Hh mutants are degraded by ERAD R-HSA-5362768 3.834476e-04 3.416 0 0
SPOP-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929491 3.834476e-04 3.416 0 0
Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 4.278951e-04 3.369 0 0
EGFR downregulation R-HSA-182971 4.200859e-04 3.377 0 0
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 4.200859e-04 3.377 0 0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 4.065111e-04 3.391 0 0
B-WICH complex positively regulates rRNA expression R-HSA-5250924 4.065111e-04 3.391 0 0
Deubiquitination R-HSA-5688426 4.552114e-04 3.342 0 0
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 4.562775e-04 3.341 0 0
MAP2K and MAPK activation R-HSA-5674135 4.386096e-04 3.358 0 0
Platelet activation, signaling and aggregation R-HSA-76002 4.621807e-04 3.335 0 0
Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811442 4.208279e-04 3.376 0 0
Assembly of the pre-replicative complex R-HSA-68867 4.030793e-04 3.395 0 0
DNA Replication Pre-Initiation R-HSA-69002 4.999571e-04 3.301 0 0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells R-HSA-9927418 5.000449e-04 3.301 0 0
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 5.109446e-04 3.292 0 0
NRIF signals cell death from the nucleus R-HSA-205043 5.179919e-04 3.286 0 0
MAPK1/MAPK3 signaling R-HSA-5684996 5.296166e-04 3.276 0 0
DNA Replication R-HSA-69306 5.329939e-04 3.273 0 0
Developmental Lineage of Mammary Stem Cells R-HSA-9938206 5.674031e-04 3.246 0 0
Hh mutants abrogate ligand secretion R-HSA-5387390 5.682715e-04 3.245 0 0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 5.708722e-04 3.243 0 0
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 6.438324e-04 3.191 0 0
APC/C-mediated degradation of cell cycle proteins R-HSA-174143 6.441441e-04 3.191 0 0
Regulation of mitotic cell cycle R-HSA-453276 6.441441e-04 3.191 0 0
Translesion synthesis by REV1 R-HSA-110312 6.594500e-04 3.181 0 0
Protein methylation R-HSA-8876725 6.594500e-04 3.181 0 0
InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 6.594500e-04 3.181 0 0
Spry regulation of FGF signaling R-HSA-1295596 6.594500e-04 3.181 0 0
p75NTR signals via NF-kB R-HSA-193639 6.594500e-04 3.181 0 0
Vpu mediated degradation of CD4 R-HSA-180534 6.623664e-04 3.179 0 0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation R-HSA-9828211 7.059917e-04 3.151 0 0
Myoclonic epilepsy of Lafora R-HSA-3785653 7.059917e-04 3.151 0 0
Downregulation of ERBB4 signaling R-HSA-1253288 7.059917e-04 3.151 0 0
Modulation by Mtb of host immune system R-HSA-9637628 7.059917e-04 3.151 0 0
G2/M Checkpoints R-HSA-69481 7.095054e-04 3.149 0 0
Hemostasis R-HSA-109582 7.130611e-04 3.147 0 0
Defective CFTR causes cystic fibrosis R-HSA-5678895 7.272955e-04 3.138 0 0
Translesion synthesis by POLI R-HSA-5656121 8.279968e-04 3.082 0 0
Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 8.775969e-04 3.057 0 0
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 8.192530e-04 3.087 0 0
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 9.203219e-04 3.036 0 0
Metabolism of non-coding RNA R-HSA-194441 7.860580e-04 3.105 0 0
snRNP Assembly R-HSA-191859 7.860580e-04 3.105 0 0
Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-159236 7.772999e-04 3.109 0 0
Protein ubiquitination R-HSA-8852135 9.323179e-04 3.030 0 0
mRNA Splicing - Major Pathway R-HSA-72163 7.934227e-04 3.100 0 0
Signaling by ERBB2 R-HSA-1227986 8.709494e-04 3.060 0 0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 8.775969e-04 3.057 0 0
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 8.775969e-04 3.057 0 0
RAF/MAP kinase cascade R-HSA-5673001 8.934157e-04 3.049 0 0
Clathrin-mediated endocytosis R-HSA-8856828 8.194188e-04 3.086 0 0
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 7.640072e-04 3.117 0 0
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815 7.640072e-04 3.117 0 0
Regulation of Apoptosis R-HSA-169911 8.775969e-04 3.057 0 0
Export of Viral Ribonucleoproteins from Nucleus R-HSA-168274 8.192530e-04 3.087 0 0
Negative regulation of FLT3 R-HSA-9706369 8.279968e-04 3.082 0 0
Non-integrin membrane-ECM interactions R-HSA-3000171 9.323179e-04 3.030 0 0
IRAK2 mediated activation of TAK1 complex R-HSA-937042 9.724410e-04 3.012 0 0
Vif-mediated degradation of APOBEC3G R-HSA-180585 1.004098e-03 2.998 0 0
FLT3 signaling in disease R-HSA-9682385 1.004098e-03 2.998 0 0
Anchoring of the basal body to the plasma membrane R-HSA-5620912 1.011526e-03 2.995 0 0
Glucose metabolism R-HSA-70326 1.023460e-03 2.990 0 0
Translesion synthesis by POLK R-HSA-5655862 1.026718e-03 2.989 0 0
Vpr-mediated nuclear import of PICs R-HSA-180910 1.144512e-03 2.941 0 0
Degradation of DVL R-HSA-4641258 1.144512e-03 2.941 0 0
Degradation of AXIN R-HSA-4641257 1.144512e-03 2.941 0 0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114 1.144512e-03 2.941 0 0
DNA Damage Bypass R-HSA-73893 1.152382e-03 2.938 0 0
G1/S DNA Damage Checkpoints R-HSA-69615 1.171289e-03 2.931 0 0
EPH-Ephrin signaling R-HSA-2682334 1.279174e-03 2.893 0 0
Regulation of RAS by GAPs R-HSA-5658442 1.284727e-03 2.891 0 0
Rev-mediated nuclear export of HIV RNA R-HSA-165054 1.299874e-03 2.886 0 0
TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9014325 1.302675e-03 2.885 0 0
Pexophagy R-HSA-9664873 1.302675e-03 2.885 0 0
KEAP1-NFE2L2 pathway R-HSA-9755511 1.315128e-03 2.881 0 0
Nuclear events mediated by NFE2L2 R-HSA-9759194 1.333831e-03 2.875 0 0
mRNA Splicing R-HSA-72172 1.380449e-03 2.860 0 0
Activation of NF-kappaB in B cells R-HSA-1169091 1.428890e-03 2.845 0 0
GSK3B-mediated proteasomal degradation of PD-L1(CD274) R-HSA-9929356 1.471256e-03 2.832 0 0
NS1 Mediated Effects on Host Pathways R-HSA-168276 1.471256e-03 2.832 0 0
Regulation of TP53 Activity through Methylation R-HSA-6804760 1.527498e-03 2.816 0 0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) R-HSA-9931269 1.585604e-03 2.800 0 0
Orc1 removal from chromatin R-HSA-68949 1.585604e-03 2.800 0 0
Interactions of Vpr with host cellular proteins R-HSA-176033 1.659762e-03 2.780 0 0
Transport of Mature Transcript to Cytoplasm R-HSA-72202 1.686602e-03 2.773 0 0
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 1.686602e-03 2.773 0 0
PTEN Regulation R-HSA-6807070 1.698649e-03 2.770 0 0
Alpha-protein kinase 1 signaling pathway R-HSA-9645460 1.704175e-03 2.768 0 0
InlA-mediated entry of Listeria monocytogenes into host cells R-HSA-8876493 1.704175e-03 2.768 0 0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 1.755626e-03 2.756 0 0
Regulation of PTEN stability and activity R-HSA-8948751 1.755626e-03 2.756 0 0
Termination of translesion DNA synthesis R-HSA-5656169 1.760332e-03 2.754 0 0
Late endosomal microautophagy R-HSA-9615710 1.760332e-03 2.754 0 0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 1.866528e-03 2.729 0 0
NIK-->noncanonical NF-kB signaling R-HSA-5676590 1.866528e-03 2.729 0 0
Loss of MECP2 binding ability to 5hmC-DNA R-HSA-9022534 2.403318e-03 2.619 0 0
APC-Cdc20 mediated degradation of Nek2A R-HSA-179409 2.586876e-03 2.587 0 0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 2.024025e-03 2.694 0 0
IP3 and IP4 transport between cytosol and nucleus R-HSA-1855196 2.316515e-03 2.635 0 0
IP6 and IP7 transport between cytosol and nucleus R-HSA-1855229 2.316515e-03 2.635 0 0
Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 2.353412e-03 2.628 0 0
Late Phase of HIV Life Cycle R-HSA-162599 2.133678e-03 2.671 0 0
Positive epigenetic regulation of rRNA expression R-HSA-5250913 2.395309e-03 2.621 0 0
Negative regulators of DDX58/IFIH1 signaling R-HSA-936440 2.316515e-03 2.635 0 0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 R-HSA-9824878 2.184346e-03 2.661 0 0
Degradation of CRY and PER proteins R-HSA-9932298 2.092721e-03 2.679 0 0
Negative regulation of MET activity R-HSA-6807004 2.188138e-03 2.660 0 0
NFE2L2 regulates pentose phosphate pathway genes R-HSA-9818028 2.184346e-03 2.661 0 0
Degradation of GLI1 by the proteasome R-HSA-5610780 2.092721e-03 2.679 0 0
Signaling by TGF-beta Receptor Complex R-HSA-170834 1.989652e-03 2.701 0 0
Evasion by RSV of host interferon responses R-HSA-9833109 2.316515e-03 2.635 0 0
ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 2.184346e-03 2.661 0 0
Degradation of GLI2 by the proteasome R-HSA-5610783 2.092721e-03 2.679 0 0
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 2.092721e-03 2.679 0 0
Negative regulation of MAPK pathway R-HSA-5675221 2.092721e-03 2.679 0 0
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 2.586876e-03 2.587 0 0
Vesicle-mediated transport R-HSA-5653656 2.192697e-03 2.659 0 0
Prevention of phagosomal-lysosomal fusion R-HSA-9636383 2.586876e-03 2.587 0 0
TICAM1-dependent activation of IRF3/IRF7 R-HSA-9013973 2.184346e-03 2.661 0 0
NF-kB is activated and signals survival R-HSA-209560 2.184346e-03 2.661 0 0
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988 2.339534e-03 2.631 0 0
Formation of the dystrophin-glycoprotein complex (DGC) R-HSA-9913351 2.316515e-03 2.635 0 0
Transcriptional regulation by RUNX3 R-HSA-8878159 1.989652e-03 2.701 0 0
Nephrin family interactions R-HSA-373753 2.188138e-03 2.660 0 0
Response of Mtb to phagocytosis R-HSA-9637690 2.608189e-03 2.584 0 0
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285 2.750463e-03 2.561 0 0
Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 2.750463e-03 2.561 0 0
Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 2.750463e-03 2.561 0 0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 2.750463e-03 2.561 0 0
IRAK1 recruits IKK complex R-HSA-937039 2.750463e-03 2.561 0 0
VLDLR internalisation and degradation R-HSA-8866427 2.750463e-03 2.561 0 0
Switching of origins to a post-replicative state R-HSA-69052 2.821525e-03 2.550 0 0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260 2.899930e-03 2.538 0 0
RMTs methylate histone arginines R-HSA-3214858 2.899930e-03 2.538 0 0
IPs transport between nucleus and cytosol R-HSA-1855170 2.995634e-03 2.524 0 0
Transport of the SLBP independent Mature mRNA R-HSA-159227 2.995634e-03 2.524 0 0
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982 3.035804e-03 2.518 0 0
activated TAK1 mediates p38 MAPK activation R-HSA-450302 3.035804e-03 2.518 0 0
Listeria monocytogenes entry into host cells R-HSA-8876384 3.035804e-03 2.518 0 0
Initiation of Nuclear Envelope (NE) Reformation R-HSA-2995383 3.035804e-03 2.518 0 0
Assembly Of The HIV Virion R-HSA-175474 3.035804e-03 2.518 0 0
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462 3.035804e-03 2.518 0 0
Neuronal System R-HSA-112316 3.182539e-03 2.497 0 0
Nucleosome assembly R-HSA-774815 3.216026e-03 2.493 0 0
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 3.216026e-03 2.493 0 0
NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-168333 3.216026e-03 2.493 0 0
Asymmetric localization of PCP proteins R-HSA-4608870 3.216026e-03 2.493 0 0
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 3.216026e-03 2.493 0 0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 3.216026e-03 2.493 0 0
p53-Independent G1/S DNA Damage Checkpoint R-HSA-69613 3.216026e-03 2.493 0 0
Transport of the SLBP Dependant Mature mRNA R-HSA-159230 3.386207e-03 2.470 0 0
Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 3.386207e-03 2.470 0 0
Membrane binding and targetting of GAG proteins R-HSA-174490 3.409624e-03 2.467 0 0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 3.409624e-03 2.467 0 0
ATF6 (ATF6-alpha) activates chaperones R-HSA-381033 3.409624e-03 2.467 0 0
mTORC1-mediated signalling R-HSA-166208 3.538368e-03 2.451 0 0
Downregulation of TGF-beta receptor signaling R-HSA-2173788 3.538368e-03 2.451 0 0
Transcriptional Regulation by MECP2 R-HSA-8986944 3.551700e-03 2.450 0 0
Regulation of pyruvate metabolism R-HSA-9861718 3.557763e-03 2.449 0 0
MAPK family signaling cascades R-HSA-5683057 3.690469e-03 2.433 0 0
Chromosome Maintenance R-HSA-73886 3.797477e-03 2.421 0 0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex R-HSA-9843970 3.813457e-03 2.419 0 0
Dual Incision in GG-NER R-HSA-5696400 3.813457e-03 2.419 0 0
Respiratory Syncytial Virus Infection Pathway R-HSA-9820952 4.064953e-03 2.391 0 0
Synthesis of DNA R-HSA-69239 4.108193e-03 2.386 0 0
PCP/CE pathway R-HSA-4086400 4.151538e-03 2.382 0 0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 4.168704e-03 2.380 0 0
Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-174495 4.168704e-03 2.380 0 0
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 4.168704e-03 2.380 0 0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 4.275572e-03 2.369 0 0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells R-HSA-9860927 4.279405e-03 2.369 0 0
Signal Transduction R-HSA-162582 4.304131e-03 2.366 0 0
rRNA modification in the nucleus and cytosol R-HSA-6790901 4.368280e-03 2.360 0 0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 4.718141e-03 2.326 0 0
Neurodegenerative Diseases R-HSA-8863678 4.718141e-03 2.326 0 0
Signaling by MET R-HSA-6806834 4.803415e-03 2.318 0 0
TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-937072 5.034323e-03 2.298 0 0
TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168927 5.034323e-03 2.298 0 0
Manipulation of host energy metabolism R-HSA-9636667 5.282264e-03 2.277 0 0
Breakdown of the nuclear lamina R-HSA-352238 5.282264e-03 2.277 0 0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.975144e-03 2.156 0 0
Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159231 6.570833e-03 2.182 0 0
Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-159234 7.260757e-03 2.139 0 0
RNA Polymerase I Promoter Escape R-HSA-73772 6.220761e-03 2.206 0 0
Meiotic synapsis R-HSA-1221632 6.779273e-03 2.169 0 0
Cyclin E associated events during G1/S transition R-HSA-69202 7.504549e-03 2.125 0 0
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009 6.975144e-03 2.156 0 0
Regulation of PD-L1(CD274) Post-translational modification R-HSA-9909615 7.243546e-03 2.140 0 0
Regulation of innate immune responses to cytosolic DNA R-HSA-3134975 7.110204e-03 2.148 0 0
Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.335521e-03 2.273 0 0
Uptake and function of diphtheria toxin R-HSA-5336415 5.714138e-03 2.243 0 0
TNFR1-induced NF-kappa-B signaling pathway R-HSA-5357956 6.975144e-03 2.156 0 0
HATs acetylate histones R-HSA-3214847 6.772117e-03 2.169 0 0
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 6.153396e-03 2.211 0 0
Negative regulation of FGFR3 signaling R-HSA-5654732 7.870620e-03 2.104 0 0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 5.697281e-03 2.244 0 0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) R-HSA-936964 7.110204e-03 2.148 0 0
Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168271 8.001540e-03 2.097 0 0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 7.110204e-03 2.148 0 0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.335521e-03 2.273 0 0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 7.110204e-03 2.148 0 0
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671 5.535722e-03 2.257 0 0
Regulation of NF-kappa B signaling R-HSA-9758274 6.012816e-03 2.221 0 0
Signaling by NOTCH R-HSA-157118 6.393651e-03 2.194 0 0
Suppression of phagosomal maturation R-HSA-9637687 6.153396e-03 2.211 0 0
Regulation of BACH1 activity R-HSA-9708530 6.012816e-03 2.221 0 0
Transport to the Golgi and subsequent modification R-HSA-948021 6.581653e-03 2.182 0 0
FLT3 Signaling R-HSA-9607240 8.001540e-03 2.097 0 0
HDACs deacetylate histones R-HSA-3214815 8.006862e-03 2.097 0 0
Signaling by NOTCH3 R-HSA-9012852 8.006862e-03 2.097 0 0
Constitutive Signaling by EGFRvIII R-HSA-5637810 8.332172e-03 2.079 0 0
Signaling by EGFRvIII in Cancer R-HSA-5637812 8.332172e-03 2.079 0 0
Regulation of FZD by ubiquitination R-HSA-4641263 8.332172e-03 2.079 0 0
Glycogen storage diseases R-HSA-3229121 8.332172e-03 2.079 0 0
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 8.652840e-03 2.063 0 0
Diseases of programmed cell death R-HSA-9645723 8.772571e-03 2.057 0 0
Negative regulation of FGFR4 signaling R-HSA-5654733 8.842964e-03 2.053 0 0
Signaling by CSF3 (G-CSF) R-HSA-9674555 8.842964e-03 2.053 0 0
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 9.060626e-03 2.043 0 0
Post-translational protein modification R-HSA-597592 9.142651e-03 2.039 0 0
Drug resistance in ERBB2 KD mutants R-HSA-9665230 9.173901e-03 2.037 0 0
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282 9.173901e-03 2.037 0 0
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249 9.173901e-03 2.037 0 0
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244 9.173901e-03 2.037 0 0
TGFBR1 LBD Mutants in Cancer R-HSA-3656535 9.173901e-03 2.037 0 0
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245 9.173901e-03 2.037 0 0
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250 9.173901e-03 2.037 0 0
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251 9.173901e-03 2.037 0 0
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246 9.173901e-03 2.037 0 0
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247 9.173901e-03 2.037 0 0
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737 9.173901e-03 2.037 0 0
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233 9.173901e-03 2.037 0 0
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998 9.273963e-03 2.033 0 0
DNA Double-Strand Break Repair R-HSA-5693532 9.315135e-03 2.031 0 0
ER-Phagosome pathway R-HSA-1236974 9.333019e-03 2.030 0 0
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 9.374017e-03 2.028 0 0
Regulation of PD-L1(CD274) expression R-HSA-9909648 9.596738e-03 2.018 0 0
Signaling by ERBB2 ECD mutants R-HSA-9665348 9.684058e-03 2.014 0 0
Signaling by ERBB2 in Cancer R-HSA-1227990 9.895231e-03 2.005 0 0
Signaling by ERBB4 R-HSA-1236394 9.927726e-03 2.003 0 0
Dual incision in TC-NER R-HSA-6782135 1.014510e-02 1.994 0 0
Signaling by FGFR4 R-HSA-5654743 1.054879e-02 1.977 0 0
Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 1.061512e-02 1.974 0 0
Trafficking of AMPA receptors R-HSA-399719 1.103038e-02 1.957 0 0
Budding and maturation of HIV virion R-HSA-162588 1.103038e-02 1.957 0 0
IKK complex recruitment mediated by RIP1 R-HSA-937041 1.117083e-02 1.952 0 0
Unfolded Protein Response (UPR) R-HSA-381119 1.119872e-02 1.951 0 0
EPHB-mediated forward signaling R-HSA-3928662 1.151261e-02 1.939 0 0
Folding of actin by CCT/TriC R-HSA-390450 1.161340e-02 1.935 0 0
CaMK IV-mediated phosphorylation of CREB R-HSA-111932 1.161340e-02 1.935 0 0
Signaling by FGFR3 R-HSA-5654741 1.253694e-02 1.902 0 0
Viral Messenger RNA Synthesis R-HSA-168325 1.267185e-02 1.897 0 0
Regulation of RUNX2 expression and activity R-HSA-8939902 1.267185e-02 1.897 0 0
Protein hydroxylation R-HSA-9629569 1.279709e-02 1.893 0 0
Glycogen synthesis R-HSA-3322077 1.279709e-02 1.893 0 0
ABC transporter disorders R-HSA-5619084 1.288890e-02 1.890 0 0
TCR signaling R-HSA-202403 1.320530e-02 1.879 0 0
Regulation of necroptotic cell death R-HSA-5675482 1.356063e-02 1.868 0 0
Negative regulation of FGFR1 signaling R-HSA-5654726 1.356063e-02 1.868 0 0
Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-399721 1.356063e-02 1.868 0 0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742 1.356063e-02 1.868 0 0
tRNA processing in the nucleus R-HSA-6784531 1.360659e-02 1.866 0 0
Regulation of TNFR1 signaling R-HSA-5357905 1.362361e-02 1.866 0 0
Loss of MECP2 binding ability to 5mC-DNA R-HSA-9022538 1.400429e-02 1.854 0 0
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928 1.404477e-02 1.852 0 0
Early Phase of HIV Life Cycle R-HSA-162594 1.456703e-02 1.837 0 0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 1.456703e-02 1.837 0 0
PD-L1(CD274) glycosylation and translocation to plasma membrane R-HSA-9931295 1.456703e-02 1.837 0 0
EPH-ephrin mediated repulsion of cells R-HSA-3928665 1.477438e-02 1.830 0 0
DNA Damage Recognition in GG-NER R-HSA-5696394 1.496109e-02 1.825 0 0
Amyloid fiber formation R-HSA-977225 1.550044e-02 1.810 0 0
RAF activation R-HSA-5673000 1.645516e-02 1.784 0 0
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350 1.645516e-02 1.784 0 0
Negative regulation of FGFR2 signaling R-HSA-5654727 1.645516e-02 1.784 0 0
Signaling by NOTCH2 R-HSA-1980145 1.645516e-02 1.784 0 0
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066 1.648450e-02 1.783 0 0
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324 1.648450e-02 1.783 0 0
Telomere Maintenance R-HSA-157579 1.652796e-02 1.782 0 0
Cellular response to hypoxia R-HSA-1234174 1.670616e-02 1.777 0 0
Integration of provirus R-HSA-162592 1.694191e-02 1.771 0 0
S Phase R-HSA-69242 1.731849e-02 1.761 0 0
Oncogene Induced Senescence R-HSA-2559585 1.804520e-02 1.744 0 0
p75 NTR receptor-mediated signalling R-HSA-193704 1.835282e-02 1.736 0 0
Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696399 1.847530e-02 1.733 0 0
VEGFA-VEGFR2 Pathway R-HSA-4420097 1.863381e-02 1.730 0 0
Meiosis R-HSA-1500620 1.955193e-02 1.709 0 0
MAPK6/MAPK4 signaling R-HSA-5687128 1.955193e-02 1.709 0 0
MECP2 regulates transcription of genes involved in GABA signaling R-HSA-9022927 1.970338e-02 1.705 0 0
PLCG1 events in ERBB2 signaling R-HSA-1251932 1.970338e-02 1.705 0 0
MTF1 activates gene expression R-HSA-5660489 1.970338e-02 1.705 0 0
Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662360 2.027431e-02 1.693 0 0
Syndecan interactions R-HSA-3000170 2.077532e-02 1.682 0 0
Protein localization R-HSA-9609507 2.118921e-02 1.674 0 0
Homology Directed Repair R-HSA-5693538 2.140354e-02 1.670 0 0
Estrogen-dependent gene expression R-HSA-9018519 2.285384e-02 1.641 0 0
Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 2.292882e-02 1.640 0 0
Degradation of beta-catenin by the destruction complex R-HSA-195253 2.292882e-02 1.640 0 0
Pyruvate metabolism R-HSA-70268 2.304915e-02 1.637 0 0
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686 2.315437e-02 1.635 0 0
RIPK1-mediated regulated necrosis R-HSA-5213460 2.341283e-02 1.631 0 0
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 2.342508e-02 1.630 0 0
NoRC negatively regulates rRNA expression R-HSA-427413 2.434206e-02 1.614 0 0
Hedgehog 'on' state R-HSA-5632684 2.434206e-02 1.614 0 0
RAS processing R-HSA-9648002 2.540771e-02 1.595 0 0
Pentose phosphate pathway R-HSA-71336 2.540771e-02 1.595 0 0
Long-term potentiation R-HSA-9620244 2.569234e-02 1.590 0 0
Nucleotide Excision Repair R-HSA-5696398 2.589580e-02 1.587 0 0
Loss of Function of TGFBR1 in Cancer R-HSA-3656534 2.620489e-02 1.582 0 0
Loss of phosphorylation of MECP2 at T308 R-HSA-9022535 2.620489e-02 1.582 0 0
Toxicity of botulinum toxin type G (botG) R-HSA-5250989 2.620489e-02 1.582 0 0
NFE2L2 regulating TCA cycle genes R-HSA-9818025 2.620489e-02 1.582 0 0
Maternal to zygotic transition (MZT) R-HSA-9816359 2.666724e-02 1.574 0 0
Downstream TCR signaling R-HSA-202424 2.696481e-02 1.569 0 0
Co-inhibition by PD-1 R-HSA-389948 2.717066e-02 1.566 0 0
Inhibition of DNA recombination at telomere R-HSA-9670095 2.750833e-02 1.561 0 0
Signaling by TGFB family members R-HSA-9006936 2.763993e-02 1.558 0 0
TNF signaling R-HSA-75893 2.828323e-02 1.548 0 0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 2.828323e-02 1.548 0 0
Signaling by FGFR1 R-HSA-5654736 2.828323e-02 1.548 0 0
Sensory processing of sound by outer hair cells of the cochlea R-HSA-9662361 2.828323e-02 1.548 0 0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 2.971618e-02 1.527 0 0
M-decay: degradation of maternal mRNAs by maternally stored factors R-HSA-9820841 2.971618e-02 1.527 0 0
Antigen processing-Cross presentation R-HSA-1236975 2.971877e-02 1.527 0 0
IRE1alpha activates chaperones R-HSA-381070 2.981818e-02 1.526 0 0
Signaling by VEGF R-HSA-194138 3.023735e-02 1.519 0 0
G1/S Transition R-HSA-69206 3.023735e-02 1.519 0 0
Pentose phosphate pathway disease R-HSA-6791465 3.344606e-02 1.476 0 0
Noncanonical activation of NOTCH3 R-HSA-9017802 3.344606e-02 1.476 0 0
Loss of MECP2 binding ability to the NCoR/SMRT complex R-HSA-9022537 3.344606e-02 1.476 0 0
PTK6 promotes HIF1A stabilization R-HSA-8857538 4.136754e-02 1.383 0 0
MECP2 regulates transcription factors R-HSA-9022707 4.991320e-02 1.302 0 0
Type I hemidesmosome assembly R-HSA-446107 5.902998e-02 1.229 0 0
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.902998e-02 1.229 0 0
Formation of annular gap junctions R-HSA-196025 5.902998e-02 1.229 0 0
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 3.532299e-02 1.452 0 0
GRB2 events in ERBB2 signaling R-HSA-1963640 3.986093e-02 1.399 0 0
p130Cas linkage to MAPK signaling for integrins R-HSA-372708 4.467886e-02 1.350 0 0
EPHA-mediated growth cone collapse R-HSA-3928663 3.125221e-02 1.505 0 0
Packaging Of Telomere Ends R-HSA-171306 3.125221e-02 1.505 0 0
Signaling by ERBB2 KD Mutants R-HSA-9664565 3.746563e-02 1.426 0 0
DNA methylation R-HSA-5334118 3.746563e-02 1.426 0 0
Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-917729 3.746563e-02 1.426 0 0
Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.587820e-02 1.253 0 0
Formation of TC-NER Pre-Incision Complex R-HSA-6781823 4.528081e-02 1.344 0 0
Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.137080e-02 1.289 0 0
Regulation of PTEN gene transcription R-HSA-8943724 3.627597e-02 1.440 0 0
Developmental Lineage of Pancreatic Ductal Cells R-HSA-9925563 5.914880e-02 1.228 0 0
Amplification of signal from the kinetochores R-HSA-141424 5.305588e-02 1.275 0 0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.305588e-02 1.275 0 0
Regulation of endogenous retroelements R-HSA-9842860 5.133428e-02 1.290 0 0
SHC1 events in ERBB2 signaling R-HSA-1250196 4.081920e-02 1.389 0 0
GAB1 signalosome R-HSA-180292 4.977193e-02 1.303 0 0
Toxicity of botulinum toxin type B (botB) R-HSA-5250958 5.902998e-02 1.229 0 0
Condensation of Prophase Chromosomes R-HSA-2299718 4.528081e-02 1.344 0 0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 3.415610e-02 1.467 0 0
Serotonin Neurotransmitter Release Cycle R-HSA-181429 4.977193e-02 1.303 0 0
Peroxisomal protein import R-HSA-9033241 3.415610e-02 1.467 0 0
Mitotic Spindle Checkpoint R-HSA-69618 4.720266e-02 1.326 0 0
RNA Polymerase I Transcription R-HSA-73864 3.593006e-02 1.445 0 0
DNA Double Strand Break Response R-HSA-5693606 5.346613e-02 1.272 0 0
MTOR signalling R-HSA-165159 3.445890e-02 1.463 0 0
Aryl hydrocarbon receptor signalling R-HSA-8937144 3.344606e-02 1.476 0 0
RNA Polymerase I Promoter Clearance R-HSA-73854 3.230758e-02 1.491 0 0
Negative epigenetic regulation of rRNA expression R-HSA-5250941 3.981123e-02 1.400 0 0
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351 4.136754e-02 1.383 0 0
Sema4D induced cell migration and growth-cone collapse R-HSA-416572 6.076072e-02 1.216 0 0
PIP3 activates AKT signaling R-HSA-1257604 6.127811e-02 1.213 0 0
Sema3A PAK dependent Axon repulsion R-HSA-399954 3.106909e-02 1.508 0 0
RNA Polymerase I Promoter Opening R-HSA-73728 3.125221e-02 1.505 0 0
Meiotic recombination R-HSA-912446 6.136049e-02 1.212 0 0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes R-HSA-9856532 5.513460e-02 1.259 0 0
Intracellular signaling by second messengers R-HSA-9006925 3.719644e-02 1.429 0 0
DNA Repair R-HSA-73894 5.560521e-02 1.255 0 0
CHL1 interactions R-HSA-447041 4.991320e-02 1.302 0 0
Activation of BAD and translocation to mitochondria R-HSA-111447 3.106909e-02 1.508 0 0
Fanconi Anemia Pathway R-HSA-6783310 4.240631e-02 1.373 0 0
MAP kinase activation R-HSA-450294 3.847845e-02 1.415 0 0
ESR-mediated signaling R-HSA-8939211 4.443999e-02 1.352 0 0
Signaling by Hippo R-HSA-2028269 4.467886e-02 1.350 0 0
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989 4.826888e-02 1.316 0 0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 5.902998e-02 1.229 0 0
TCF dependent signaling in response to WNT R-HSA-201681 3.101359e-02 1.508 0 0
NOD1/2 Signaling Pathway R-HSA-168638 6.005079e-02 1.221 0 0
Reproduction R-HSA-1474165 3.836613e-02 1.416 0 0
Death Receptor Signaling R-HSA-73887 4.639345e-02 1.334 0 0
HCMV Late Events R-HSA-9610379 5.122891e-02 1.290 0 0
Signaling by FGFR2 R-HSA-5654738 3.981123e-02 1.400 0 0
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 4.802064e-02 1.319 0 0
Transcriptional regulation by RUNX1 R-HSA-8878171 3.247278e-02 1.488 0 0
Gluconeogenesis R-HSA-70263 5.137080e-02 1.289 0 0
Processing of DNA double-strand break ends R-HSA-5693607 4.185051e-02 1.378 0 0
Sensory processing of sound R-HSA-9659379 3.783796e-02 1.422 0 0
ER Quality Control Compartment (ERQC) R-HSA-901032 3.125221e-02 1.505 0 0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 5.458672e-02 1.263 0 0
Interleukin-1 signaling R-HSA-9020702 4.924034e-02 1.308 0 0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation R-HSA-163841 5.550187e-02 1.256 0 0
Negative Regulation of CDH1 Gene Transcription R-HSA-9764725 3.627597e-02 1.440 0 0
RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 4.991320e-02 1.302 0 0
Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.902998e-02 1.229 0 0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779 3.106909e-02 1.508 0 0
Recognition and association of DNA glycosylase with site containing an affected purine R-HSA-110330 4.802064e-02 1.319 0 0
Regulated Necrosis R-HSA-5218859 5.626418e-02 1.250 0 0
Signal transduction by L1 R-HSA-445144 6.076072e-02 1.216 0 0
Assembly of the ORC complex at the origin of replication R-HSA-68616 5.186778e-02 1.285 0 0
Adaptive Immune System R-HSA-1280218 5.710783e-02 1.243 0 0
Beta-catenin independent WNT signaling R-HSA-3858494 4.961932e-02 1.304 0 0
Transcriptional regulation by RUNX2 R-HSA-8878166 5.083329e-02 1.294 0 0
TNFR2 non-canonical NF-kB pathway R-HSA-5668541 4.612938e-02 1.336 0 0
Somitogenesis R-HSA-9824272 4.240631e-02 1.373 0 0
Signaling by the B Cell Receptor (BCR) R-HSA-983705 5.291343e-02 1.276 0 0
Calnexin/calreticulin cycle R-HSA-901042 6.005079e-02 1.221 0 0
ABC-family proteins mediated transport R-HSA-382556 4.720266e-02 1.326 0 0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways R-HSA-9735871 3.106909e-02 1.508 0 0
NPAS4 regulates expression of target genes R-HSA-9768919 6.005079e-02 1.221 0 0
Cellular response to chemical stress R-HSA-9711123 5.553368e-02 1.255 0 0
Cyclin D associated events in G1 R-HSA-69231 3.964491e-02 1.402 0 0
G1 Phase R-HSA-69236 3.964491e-02 1.402 0 0
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.550187e-02 1.256 0 0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567 3.851381e-02 1.414 0 0
Metabolism of carbohydrates and carbohydrate derivatives R-HSA-71387 5.759842e-02 1.240 0 0
XBP1(S) activates chaperone genes R-HSA-381038 5.550187e-02 1.256 0 0
Disorders of transmembrane transporters R-HSA-5619115 5.776894e-02 1.238 0 0
PINK1-PRKN Mediated Mitophagy R-HSA-5205685 3.427679e-02 1.465 0 0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine R-HSA-110328 6.005079e-02 1.221 0 0
Mitophagy R-HSA-5205647 6.005079e-02 1.221 0 0
HDR through Homologous Recombination (HRR) R-HSA-5685942 5.346613e-02 1.272 0 0
Interleukin-17 signaling R-HSA-448424 6.212014e-02 1.207 0 0
Regulation of CDH1 Gene Transcription R-HSA-9764560 6.212014e-02 1.207 0 0
Uptake and actions of bacterial toxins R-HSA-5339562 6.491793e-02 1.188 0 0
Transcriptional and post-translational regulation of MITF-M expression and activity R-HSA-9856649 6.517824e-02 1.186 0 0
Base Excision Repair R-HSA-73884 6.597912e-02 1.181 0 0
Basigin interactions R-HSA-210991 6.664355e-02 1.176 0 0
RPIA deficiency: failed conversion of RU5P to R5P R-HSA-6791461 6.858196e-02 1.164 0 0
RPIA deficiency: failed conversion of R5P to RU5P R-HSA-5659996 6.858196e-02 1.164 0 0
Inhibition of PKR R-HSA-169131 6.858196e-02 1.164 0 0
Gap junction degradation R-HSA-190873 6.866777e-02 1.163 0 0
Hypusine synthesis from eIF5A-lysine R-HSA-204626 6.866777e-02 1.163 0 0
5-Phosphoribose 1-diphosphate biosynthesis R-HSA-73843 6.866777e-02 1.163 0 0
Calcineurin activates NFAT R-HSA-2025928 6.866777e-02 1.163 0 0
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700 6.866777e-02 1.163 0 0
Respiratory syncytial virus genome replication R-HSA-9834752 6.866777e-02 1.163 0 0
PRC2 methylates histones and DNA R-HSA-212300 6.887666e-02 1.162 0 0
Mitotic G1 phase and G1/S transition R-HSA-453279 7.141472e-02 1.146 0 0
Diseases of carbohydrate metabolism R-HSA-5663084 7.155456e-02 1.145 0 0
Signaling by PDGFR in disease R-HSA-9671555 7.277590e-02 1.138 0 0
Chromatin modifying enzymes R-HSA-3247509 7.337937e-02 1.134 0 0
SIRT1 negatively regulates rRNA expression R-HSA-427359 7.352641e-02 1.134 0 0
Cleavage of the damaged purine R-HSA-110331 7.352641e-02 1.134 0 0
G2/M DNA damage checkpoint R-HSA-69473 7.487249e-02 1.126 0 0
Depurination R-HSA-73927 7.833126e-02 1.106 0 0
Binding and entry of HIV virion R-HSA-173107 7.877924e-02 1.104 0 0
MECP2 regulates transcription of neuronal ligands R-HSA-9022702 7.877924e-02 1.104 0 0
2-LTR circle formation R-HSA-164843 7.877924e-02 1.104 0 0
EGFR Transactivation by Gastrin R-HSA-2179392 7.877924e-02 1.104 0 0
Assembly and release of respiratory syncytial virus (RSV) virions R-HSA-9820962 7.877924e-02 1.104 0 0
Dopamine Neurotransmitter Release Cycle R-HSA-212676 7.915015e-02 1.102 0 0
Respiratory syncytial virus (RSV) genome replication, transcription and translation R-HSA-9820965 8.328886e-02 1.079 0 0
Plasma lipoprotein clearance R-HSA-8964043 8.328886e-02 1.079 0 0
Cellular responses to mechanical stimuli R-HSA-9855142 8.379173e-02 1.077 0 0
Circadian clock R-HSA-9909396 8.522510e-02 1.069 0 0
Interleukin-1 family signaling R-HSA-446652 8.550588e-02 1.068 0 0
Formation of Incision Complex in GG-NER R-HSA-5696395 8.839666e-02 1.054 0 0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 8.839666e-02 1.054 0 0
Glycogen metabolism R-HSA-8982491 8.839666e-02 1.054 0 0
Regulation of localization of FOXO transcription factors R-HSA-9614399 8.931972e-02 1.049 0 0
CLEC7A (Dectin-1) signaling R-HSA-5607764 9.027903e-02 1.044 0 0
Deadenylation of mRNA R-HSA-429947 9.259209e-02 1.033 0 0
Norepinephrine Neurotransmitter Release Cycle R-HSA-181430 9.259209e-02 1.033 0 0
Chromatin modifications during the maternal to zygotic transition (MZT) R-HSA-9821002 9.365188e-02 1.028 0 0
MyD88 cascade initiated on plasma membrane R-HSA-975871 9.704627e-02 1.013 0 0
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 9.704627e-02 1.013 0 0
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 9.704627e-02 1.013 0 0
Signaling by FGFR R-HSA-190236 9.704627e-02 1.013 0 0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) R-HSA-9845323 9.739101e-02 1.011 0 0
Signaling by NOTCH1 in Cancer R-HSA-2644603 9.739101e-02 1.011 0 0
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 9.739101e-02 1.011 0 0
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 9.739101e-02 1.011 0 0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 9.739101e-02 1.011 0 0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 9.739101e-02 1.011 0 0
Translation of Structural Proteins R-HSA-9683701 9.905160e-02 1.004 0 0
Tight junction interactions R-HSA-420029 9.964297e-02 1.002 0 0
Sema4D in semaphorin signaling R-HSA-400685 9.964297e-02 1.002 0 0
Condensation of Prometaphase Chromosomes R-HSA-2514853 1.002471e-01 0.999 0 0
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 1.002471e-01 0.999 0 0
Interactions of Tat with host cellular proteins R-HSA-176034 1.010914e-01 0.995 0 0
PTEN Loss of Function in Cancer R-HSA-5674404 1.010914e-01 0.995 0 0
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P R-HSA-6791462 1.010914e-01 0.995 0 0
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P R-HSA-6791055 1.010914e-01 0.995 0 0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) R-HSA-5619050 1.010914e-01 0.995 0 0
Formation of paraxial mesoderm R-HSA-9793380 1.019372e-01 0.992 0 0
Chromatin organization R-HSA-4839726 1.034794e-01 0.985 0 0
Cleavage of the damaged pyrimidine R-HSA-110329 1.045927e-01 0.980 0 0
Depyrimidination R-HSA-73928 1.045927e-01 0.980 0 0
Transcriptional regulation of granulopoiesis R-HSA-9616222 1.065874e-01 0.972 0 0
Regulation of TP53 Activity R-HSA-5633007 1.067431e-01 0.972 0 0
Postmitotic nuclear pore complex (NPC) reformation R-HSA-9615933 1.069022e-01 0.971 0 0
Signaling by WNT R-HSA-195721 1.070497e-01 0.970 0 0
Defective pyroptosis R-HSA-9710421 1.102719e-01 0.958 0 0
Disorders of Nervous System Development R-HSA-9697154 1.115216e-01 0.953 0 0
Loss of function of MECP2 in Rett syndrome R-HSA-9005891 1.115216e-01 0.953 0 0
Pervasive developmental disorders R-HSA-9005895 1.115216e-01 0.953 0 0
Polymerase switching R-HSA-69091 1.115216e-01 0.953 0 0
Leading Strand Synthesis R-HSA-69109 1.115216e-01 0.953 0 0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors R-HSA-9820865 1.115216e-01 0.953 0 0
Scavenging by Class F Receptors R-HSA-3000484 1.115216e-01 0.953 0 0
GRB2 events in EGFR signaling R-HSA-179812 1.115216e-01 0.953 0 0
RNA Polymerase I Transcription Termination R-HSA-73863 1.143608e-01 0.942 0 0
Interaction between L1 and Ankyrins R-HSA-445095 1.143608e-01 0.942 0 0
Insulin processing R-HSA-264876 1.143608e-01 0.942 0 0
Asparagine N-linked glycosylation R-HSA-446203 1.144487e-01 0.941 0 0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 1.161933e-01 0.935 0 0
Response of endothelial cells to shear stress R-HSA-9860931 1.189662e-01 0.925 0 0
Regulation of T cell activation by CD28 family R-HSA-388841 1.197643e-01 0.922 0 0
Phase 0 - rapid depolarisation R-HSA-5576892 1.220098e-01 0.914 0 0
RSV-host interactions R-HSA-9833110 1.228500e-01 0.911 0 0
Platelet Adhesion to exposed collagen R-HSA-75892 1.231058e-01 0.910 0 0
Regulation of PD-L1(CD274) transcription R-HSA-9909649 1.261950e-01 0.899 0 0
Extracellular matrix organization R-HSA-1474244 1.262303e-01 0.899 0 0
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 1.267979e-01 0.897 0 0
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 1.324681e-01 0.878 0 0
Signaling by RAS GAP mutants R-HSA-9753510 1.324681e-01 0.878 0 0
Loss of Function of TGFBR2 in Cancer R-HSA-3642278 1.324681e-01 0.878 0 0
ATF6B (ATF6-beta) activates chaperones R-HSA-8874177 1.324681e-01 0.878 0 0
ERBB2 Activates PTK6 Signaling R-HSA-8847993 1.349645e-01 0.870 0 0
CRMPs in Sema3A signaling R-HSA-399956 1.349645e-01 0.870 0 0
Signal regulatory protein family interactions R-HSA-391160 1.349645e-01 0.870 0 0
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807 1.359148e-01 0.867 0 0
GABA synthesis, release, reuptake and degradation R-HSA-888590 1.378423e-01 0.861 0 0
Activation of BH3-only proteins R-HSA-114452 1.378423e-01 0.861 0 0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 1.390191e-01 0.857 0 0
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371 1.406156e-01 0.852 0 0
MyD88 dependent cascade initiated on endosome R-HSA-975155 1.432160e-01 0.844 0 0
NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 1.470475e-01 0.833 0 0
Erythropoietin activates RAS R-HSA-9027284 1.470644e-01 0.832 0 0
SHC1 events in EGFR signaling R-HSA-180336 1.470644e-01 0.832 0 0
ERBB2 Regulates Cell Motility R-HSA-6785631 1.470644e-01 0.832 0 0
DCC mediated attractive signaling R-HSA-418885 1.470644e-01 0.832 0 0
p38MAPK events R-HSA-171007 1.470644e-01 0.832 0 0
IRF3-mediated induction of type I IFN R-HSA-3270619 1.470644e-01 0.832 0 0
Regulation of endogenous retroelements by KRAB-ZFP proteins R-HSA-9843940 1.473244e-01 0.832 0 0
TRIF (TICAM1)-mediated TLR4 signaling R-HSA-937061 1.474731e-01 0.831 0 0
MyD88-independent TLR4 cascade R-HSA-166166 1.474731e-01 0.831 0 0
Transcriptional Regulation by TP53 R-HSA-3700989 1.503179e-01 0.823 0 0
Metabolism of amino acids and derivatives R-HSA-71291 1.518895e-01 0.818 0 0
Regulation of ornithine decarboxylase (ODC) R-HSA-350562 1.543263e-01 0.812 0 0
G0 and Early G1 R-HSA-1538133 1.543263e-01 0.812 0 0
Inositol phosphate metabolism R-HSA-1483249 1.561642e-01 0.806 0 0
KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 1.593745e-01 0.798 0 0
Phosphorylation of the APC/C R-HSA-176412 1.593745e-01 0.798 0 0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 1.593745e-01 0.798 0 0
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 1.605962e-01 0.794 0 0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins R-HSA-9673766 1.627514e-01 0.788 0 0
MET interacts with TNS proteins R-HSA-8875513 1.627514e-01 0.788 0 0
Integrin signaling R-HSA-354192 1.627895e-01 0.788 0 0
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 1.627895e-01 0.788 0 0
mRNA 3'-end processing R-HSA-72187 1.669975e-01 0.777 0 0
Transcriptional Regulation by NPAS4 R-HSA-9634815 1.669975e-01 0.777 0 0
Disorders of Developmental Biology R-HSA-9675151 1.718652e-01 0.765 0 0
Response to metal ions R-HSA-5660526 1.718652e-01 0.765 0 0
Golgi Associated Vesicle Biogenesis R-HSA-432722 1.738518e-01 0.760 0 0
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 1.742265e-01 0.759 0 0
TP53 Regulates Metabolic Genes R-HSA-5628897 1.742265e-01 0.759 0 0
Base-Excision Repair, AP Site Formation R-HSA-73929 1.808011e-01 0.743 0 0
Signaling by NOTCH1 R-HSA-1980143 1.815756e-01 0.741 0 0
PI3K events in ERBB2 signaling R-HSA-1963642 1.845092e-01 0.734 0 0
Modulation of host responses by IFN-stimulated genes R-HSA-9909505 1.845092e-01 0.734 0 0
Specification of primordial germ cells R-HSA-9827857 1.845092e-01 0.734 0 0
Signalling to ERKs R-HSA-187687 1.889552e-01 0.724 0 0
GRB7 events in ERBB2 signaling R-HSA-1306955 1.919794e-01 0.717 0 0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 1.919794e-01 0.717 0 0
TGFBR1 KD Mutants in Cancer R-HSA-3656532 1.919794e-01 0.717 0 0
TNFR1-mediated ceramide production R-HSA-5626978 1.919794e-01 0.717 0 0
NADE modulates death signalling R-HSA-205025 1.919794e-01 0.717 0 0
Toxicity of tetanus toxin (tetX) R-HSA-5250982 1.919794e-01 0.717 0 0
Gene expression (Transcription) R-HSA-74160 1.922313e-01 0.716 0 0
Signaling by Receptor Tyrosine Kinases R-HSA-9006934 1.934582e-01 0.713 0 0
Ion homeostasis R-HSA-5578775 1.949678e-01 0.710 0 0
PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 1.972806e-01 0.705 0 0
RNA Polymerase III Transcription Termination R-HSA-73980 1.972806e-01 0.705 0 0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition R-HSA-9926550 1.972806e-01 0.705 0 0
RNA Polymerase III Abortive And Retractive Initiation R-HSA-749476 1.979060e-01 0.704 0 0
RNA Polymerase III Transcription R-HSA-74158 1.979060e-01 0.704 0 0
Calmodulin induced events R-HSA-111933 1.979060e-01 0.704 0 0
CaM pathway R-HSA-111997 1.979060e-01 0.704 0 0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058 1.979927e-01 0.703 0 0
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 1.979927e-01 0.703 0 0
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312 2.021765e-01 0.694 0 0
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 2.037222e-01 0.691 0 0
Infection with Mycobacterium tuberculosis R-HSA-9635486 2.078396e-01 0.682 0 0
Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 2.094631e-01 0.679 0 0
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 2.101551e-01 0.677 0 0
STING mediated induction of host immune responses R-HSA-1834941 2.101551e-01 0.677 0 0
MITF-M-regulated melanocyte development R-HSA-9730414 2.111373e-01 0.675 0 0
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 2.128313e-01 0.672 0 0
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 2.128313e-01 0.672 0 0
MET promotes cell motility R-HSA-8875878 2.160981e-01 0.665 0 0
Extension of Telomeres R-HSA-180786 2.168232e-01 0.664 0 0
G2 Phase R-HSA-68911 2.201888e-01 0.657 0 0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768 2.201888e-01 0.657 0 0
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 2.201888e-01 0.657 0 0
Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-110381 2.201888e-01 0.657 0 0
Suppression of autophagy R-HSA-9636569 2.201888e-01 0.657 0 0
Nectin/Necl trans heterodimerization R-HSA-420597 2.201888e-01 0.657 0 0
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK R-HSA-9931529 2.201888e-01 0.657 0 0
FCERI mediated NF-kB activation R-HSA-2871837 2.221319e-01 0.653 0 0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523 2.231100e-01 0.651 0 0
Formation of definitive endoderm R-HSA-9823730 2.231100e-01 0.651 0 0
RAB geranylgeranylation R-HSA-8873719 2.242525e-01 0.649 0 0
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 2.253226e-01 0.647 0 0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin R-HSA-9725554 2.253226e-01 0.647 0 0
RNA Polymerase II Transcription Termination R-HSA-73856 2.317467e-01 0.635 0 0
Lagging Strand Synthesis R-HSA-69186 2.361241e-01 0.627 0 0
Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 2.361241e-01 0.627 0 0
Signalling to RAS R-HSA-167044 2.361241e-01 0.627 0 0
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695 2.361241e-01 0.627 0 0
C-type lectin receptors (CLRs) R-HSA-5621481 2.378930e-01 0.624 0 0
Mitochondrial protein import R-HSA-1268020 2.393014e-01 0.621 0 0
Signaling by PDGF R-HSA-186797 2.393014e-01 0.621 0 0
Innate Immune System R-HSA-168249 2.428979e-01 0.615 0 0
Epigenetic regulation of gene expression R-HSA-212165 2.430239e-01 0.614 0 0
Resolution of Abasic Sites (AP sites) R-HSA-73933 2.439869e-01 0.613 0 0
Gastrulation R-HSA-9758941 2.459604e-01 0.609 0 0
Plus-strand DNA synthesis R-HSA-164525 2.474149e-01 0.607 0 0
CDH11 homotypic and heterotypic interactions R-HSA-9833576 2.474149e-01 0.607 0 0
PTK6 Regulates Cell Cycle R-HSA-8849470 2.474149e-01 0.607 0 0
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 2.474149e-01 0.607 0 0
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 2.474149e-01 0.607 0 0
Phosphorylation of Emi1 R-HSA-176417 2.474149e-01 0.607 0 0
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349 2.474149e-01 0.607 0 0
Regulation of CDH19 Expression and Function R-HSA-9764302 2.474149e-01 0.607 0 0
TYSND1 cleaves peroxisomal proteins R-HSA-9033500 2.474149e-01 0.607 0 0
RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76066 2.491776e-01 0.603 0 0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation R-HSA-9825892 2.491776e-01 0.603 0 0
Ribavirin ADME R-HSA-9755088 2.491776e-01 0.603 0 0
Stimuli-sensing channels R-HSA-2672351 2.566761e-01 0.591 0 0
Developmental Cell Lineages of the Exocrine Pancreas R-HSA-9820448 2.606451e-01 0.584 0 0
RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76061 2.622518e-01 0.581 0 0
Neurotoxicity of clostridium toxins R-HSA-168799 2.622518e-01 0.581 0 0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 2.622518e-01 0.581 0 0
RNA Polymerase I Transcription Initiation R-HSA-73762 2.628855e-01 0.580 0 0
Ca-dependent events R-HSA-111996 2.628855e-01 0.580 0 0
RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 2.736922e-01 0.563 0 0
Autointegration results in viral DNA circles R-HSA-177539 2.736922e-01 0.563 0 0
G2/M DNA replication checkpoint R-HSA-69478 2.736922e-01 0.563 0 0
Uncoating of the HIV Virion R-HSA-162585 2.736922e-01 0.563 0 0
E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 2.736922e-01 0.563 0 0
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 2.736922e-01 0.563 0 0
Integration of viral DNA into host genomic DNA R-HSA-175567 2.736922e-01 0.563 0 0
CREB phosphorylation R-HSA-199920 2.736922e-01 0.563 0 0
Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 2.736922e-01 0.563 0 0
VLDL assembly R-HSA-8866423 2.736922e-01 0.563 0 0
Nef and signal transduction R-HSA-164944 2.736922e-01 0.563 0 0
Toxicity of botulinum toxin type F (botF) R-HSA-5250981 2.736922e-01 0.563 0 0
Toxicity of botulinum toxin type D (botD) R-HSA-5250955 2.736922e-01 0.563 0 0
Regulation of PTEN mRNA translation R-HSA-8943723 2.753294e-01 0.560 0 0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638 2.753294e-01 0.560 0 0
G-protein mediated events R-HSA-112040 2.778367e-01 0.556 0 0
Proteasome assembly R-HSA-9907900 2.819574e-01 0.550 0 0
Netrin-1 signaling R-HSA-373752 2.819574e-01 0.550 0 0
Pre-NOTCH Transcription and Translation R-HSA-1912408 2.841674e-01 0.546 0 0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 2.856670e-01 0.544 0 0
TRAF6 mediated NF-kB activation R-HSA-933542 2.883943e-01 0.540 0 0
Platelet Aggregation (Plug Formation) R-HSA-76009 2.915402e-01 0.535 0 0
DAG and IP3 signaling R-HSA-1489509 2.915402e-01 0.535 0 0
Interferon gamma signaling R-HSA-877300 2.958592e-01 0.529 0 0
Plasma lipoprotein assembly, remodeling, and clearance R-HSA-174824 2.977683e-01 0.526 0 0
Cohesin Loading onto Chromatin R-HSA-2470946 2.990535e-01 0.524 0 0
Recycling of eIF2:GDP R-HSA-72731 2.990535e-01 0.524 0 0
Disinhibition of SNARE formation R-HSA-114516 2.990535e-01 0.524 0 0
Activated NTRK2 signals through CDK5 R-HSA-9032845 2.990535e-01 0.524 0 0
SOS-mediated signalling R-HSA-112412 2.990535e-01 0.524 0 0
Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 2.990535e-01 0.524 0 0
LDL remodeling R-HSA-8964041 2.990535e-01 0.524 0 0
TGFBR3 regulates TGF-beta signaling R-HSA-9839389 2.990535e-01 0.524 0 0
mRNA Splicing - Minor Pathway R-HSA-72165 3.011449e-01 0.521 0 0
Polymerase switching on the C-strand of the telomere R-HSA-174411 3.014315e-01 0.521 0 0
VEGFR2 mediated cell proliferation R-HSA-5218921 3.014315e-01 0.521 0 0
MicroRNA (miRNA) biogenesis R-HSA-203927 3.014315e-01 0.521 0 0
Laminin interactions R-HSA-3000157 3.014315e-01 0.521 0 0
PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 3.014315e-01 0.521 0 0
Interferon alpha/beta signaling R-HSA-909733 3.108899e-01 0.507 0 0
MECP2 regulates neuronal receptors and channels R-HSA-9022699 3.144270e-01 0.502 0 0
MET activates PTK2 signaling R-HSA-8874081 3.144270e-01 0.502 0 0
Signaling by FLT3 fusion proteins R-HSA-9703465 3.144270e-01 0.502 0 0
Glutamate Neurotransmitter Release Cycle R-HSA-210500 3.144270e-01 0.502 0 0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 3.144270e-01 0.502 0 0
trans-Golgi Network Vesicle Budding R-HSA-199992 3.172659e-01 0.499 0 0
Interconversion of nucleotide di- and triphosphates R-HSA-499943 3.172659e-01 0.499 0 0
Ion channel transport R-HSA-983712 3.222282e-01 0.492 0 0
Reverse Transcription of HIV RNA R-HSA-162589 3.235307e-01 0.490 0 0
Minus-strand DNA synthesis R-HSA-164516 3.235307e-01 0.490 0 0
EGFR interacts with phospholipase C-gamma R-HSA-212718 3.235307e-01 0.490 0 0
MET receptor recycling R-HSA-8875656 3.235307e-01 0.490 0 0
Activation of RAS in B cells R-HSA-1169092 3.235307e-01 0.490 0 0
TGFBR3 PTM regulation R-HSA-9839383 3.235307e-01 0.490 0 0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-HSA-442729 3.235307e-01 0.490 0 0
Interleukin-23 signaling R-HSA-9020933 3.235307e-01 0.490 0 0
Tat-mediated HIV elongation arrest and recovery R-HSA-167243 3.273680e-01 0.485 0 0
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 3.273680e-01 0.485 0 0
Cristae formation R-HSA-8949613 3.273680e-01 0.485 0 0
Signaling by NTRK2 (TRKB) R-HSA-9006115 3.273680e-01 0.485 0 0
HIV elongation arrest and recovery R-HSA-167287 3.402423e-01 0.468 0 0
Pausing and recovery of HIV elongation R-HSA-167290 3.402423e-01 0.468 0 0
Telomere Extension By Telomerase R-HSA-171319 3.402423e-01 0.468 0 0
Iron uptake and transport R-HSA-917937 3.411498e-01 0.467 0 0
Post-translational protein phosphorylation R-HSA-8957275 3.460536e-01 0.461 0 0
Lipophagy R-HSA-9613354 3.471546e-01 0.459 0 0
ALK mutants bind TKIs R-HSA-9700645 3.471546e-01 0.459 0 0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5649702 3.471546e-01 0.459 0 0
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635 3.471546e-01 0.459 0 0
GP1b-IX-V activation signalling R-HSA-430116 3.471546e-01 0.459 0 0
Activation of the AP-1 family of transcription factors R-HSA-450341 3.471546e-01 0.459 0 0
MASTL Facilitates Mitotic Progression R-HSA-2465910 3.471546e-01 0.459 0 0
Regulated proteolysis of p75NTR R-HSA-193692 3.471546e-01 0.459 0 0
Zinc influx into cells by the SLC39 gene family R-HSA-442380 3.471546e-01 0.459 0 0
Cellular response to mitochondrial stress R-HSA-9840373 3.471546e-01 0.459 0 0
HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450520 3.471546e-01 0.459 0 0
Signaling by Erythropoietin R-HSA-9006335 3.530388e-01 0.452 0 0
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 3.530388e-01 0.452 0 0
Neddylation R-HSA-8951664 3.544793e-01 0.450 0 0
Translation of Structural Proteins R-HSA-9694635 3.571059e-01 0.447 0 0
tRNA processing R-HSA-72306 3.584336e-01 0.446 0 0
Integrin cell surface interactions R-HSA-216083 3.650837e-01 0.438 0 0
RNA Polymerase III Transcription Initiation R-HSA-76046 3.657474e-01 0.437 0 0
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139 3.657474e-01 0.437 0 0
Interleukin-37 signaling R-HSA-9008059 3.657474e-01 0.437 0 0
Extra-nuclear estrogen signaling R-HSA-9009391 3.669255e-01 0.435 0 0
MET activates RAP1 and RAC1 R-HSA-8875555 3.699549e-01 0.432 0 0
Establishment of Sister Chromatid Cohesion R-HSA-2468052 3.699549e-01 0.432 0 0
Regulation of CDH11 function R-HSA-9762292 3.699549e-01 0.432 0 0
MAPK3 (ERK1) activation R-HSA-110056 3.699549e-01 0.432 0 0
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 3.769966e-01 0.424 0 0
Respiratory syncytial virus (RSV) attachment and entry R-HSA-9820960 3.783586e-01 0.422 0 0
Molecules associated with elastic fibres R-HSA-2129379 3.783586e-01 0.422 0 0
Downstream signal transduction R-HSA-186763 3.783586e-01 0.422 0 0
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 3.796517e-01 0.421 0 0
Signaling by Nuclear Receptors R-HSA-9006931 3.872318e-01 0.412 0 0
Opioid Signalling R-HSA-111885 3.878139e-01 0.411 0 0
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 3.879208e-01 0.411 0 0
Potential therapeutics for SARS R-HSA-9679191 3.884617e-01 0.411 0 0
DNA strand elongation R-HSA-69190 3.908637e-01 0.408 0 0
Diseases of mitotic cell cycle R-HSA-9675126 3.908637e-01 0.408 0 0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells R-HSA-9937080 3.908637e-01 0.408 0 0
Fc epsilon receptor (FCERI) signaling R-HSA-2454202 3.913940e-01 0.407 0 0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 3.919602e-01 0.407 0 0
vRNP Assembly R-HSA-192905 3.919602e-01 0.407 0 0
Chylomicron assembly R-HSA-8963888 3.919602e-01 0.407 0 0
Activated NTRK3 signals through RAS R-HSA-9034864 3.919602e-01 0.407 0 0
Bicarbonate transporters R-HSA-425381 3.919602e-01 0.407 0 0
PECAM1 interactions R-HSA-210990 3.919602e-01 0.407 0 0
CD163 mediating an anti-inflammatory response R-HSA-9662834 3.919602e-01 0.407 0 0
Dissolution of Fibrin Clot R-HSA-75205 3.919602e-01 0.407 0 0
Activation of HOX genes during differentiation R-HSA-5619507 3.947700e-01 0.404 0 0
Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 3.947700e-01 0.404 0 0
Intrinsic Pathway for Apoptosis R-HSA-109606 3.970307e-01 0.401 0 0
Nuclear RNA decay R-HSA-9930044 4.032547e-01 0.394 0 0
Epigenetic regulation by WDR5-containing histone modifying complexes R-HSA-9917777 4.114000e-01 0.386 0 0
Synthesis of diphthamide-EEF2 R-HSA-5358493 4.131983e-01 0.384 0 0
Plasmalogen biosynthesis R-HSA-75896 4.131983e-01 0.384 0 0
Mitotic Telophase/Cytokinesis R-HSA-68884 4.131983e-01 0.384 0 0
Viral RNP Complexes in the Host Cell Nucleus R-HSA-168330 4.131983e-01 0.384 0 0
Activated NTRK2 signals through RAS R-HSA-9026519 4.131983e-01 0.384 0 0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane R-HSA-9768727 4.155245e-01 0.381 0 0
Deadenylation-dependent mRNA decay R-HSA-429914 4.252462e-01 0.371 0 0
Developmental Lineage of Mammary Gland Alveolar Cells R-HSA-9927426 4.276663e-01 0.369 0 0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 4.276663e-01 0.369 0 0
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 4.284808e-01 0.368 0 0
Advanced glycosylation endproduct receptor signaling R-HSA-879415 4.336958e-01 0.363 0 0
Serotonin clearance from the synaptic cleft R-HSA-380615 4.336958e-01 0.363 0 0
MET activates RAS signaling R-HSA-8851805 4.336958e-01 0.363 0 0
Trafficking and processing of endosomal TLR R-HSA-1679131 4.336958e-01 0.363 0 0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex R-HSA-9931530 4.336958e-01 0.363 0 0
SHC-related events triggered by IGF1R R-HSA-2428933 4.336958e-01 0.363 0 0
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 4.336958e-01 0.363 0 0
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731 4.336958e-01 0.363 0 0
AKT phosphorylates targets in the cytosol R-HSA-198323 4.336958e-01 0.363 0 0
OAS antiviral response R-HSA-8983711 4.336958e-01 0.363 0 0
Metabolism of polyamines R-HSA-351202 4.345517e-01 0.362 0 0
RNA polymerase II transcribes snRNA genes R-HSA-6807505 4.363085e-01 0.360 0 0
Formation of WDR5-containing histone-modifying complexes R-HSA-9772755 4.396741e-01 0.357 0 0
PERK regulates gene expression R-HSA-381042 4.396741e-01 0.357 0 0
PLC beta mediated events R-HSA-112043 4.438008e-01 0.353 0 0
Lysosome Vesicle Biogenesis R-HSA-432720 4.515425e-01 0.345 0 0
G1/S-Specific Transcription R-HSA-69205 4.515425e-01 0.345 0 0
NCAM signaling for neurite out-growth R-HSA-375165 4.529900e-01 0.344 0 0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069 4.534785e-01 0.343 0 0
Formation of axial mesoderm R-HSA-9796292 4.534785e-01 0.343 0 0
Processing of SMDT1 R-HSA-8949664 4.534785e-01 0.343 0 0
Formation of the non-canonical BAF (ncBAF) complex R-HSA-9933947 4.534785e-01 0.343 0 0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787 4.534785e-01 0.343 0 0
HDR through MMEJ (alt-NHEJ) R-HSA-5685939 4.534785e-01 0.343 0 0
Frs2-mediated activation R-HSA-170968 4.534785e-01 0.343 0 0
Interleukin-6 signaling R-HSA-1059683 4.534785e-01 0.343 0 0
Pre-NOTCH Expression and Processing R-HSA-1912422 4.568304e-01 0.340 0 0
Class I MHC mediated antigen processing & presentation R-HSA-983169 4.671388e-01 0.331 0 0
Neurotransmitter release cycle R-HSA-112310 4.672904e-01 0.330 0 0
Toll-like Receptor Cascades R-HSA-168898 4.698604e-01 0.328 0 0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 4.704061e-01 0.328 0 0
Ion transport by P-type ATPases R-HSA-936837 4.711752e-01 0.327 0 0
Removal of the Flap Intermediate R-HSA-69166 4.725713e-01 0.326 0 0
YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 4.725713e-01 0.326 0 0
Formation of the canonical BAF (cBAF) complex R-HSA-9933937 4.725713e-01 0.326 0 0
Formation of the polybromo-BAF (pBAF) complex R-HSA-9933939 4.725713e-01 0.326 0 0
Respiratory syncytial virus genome transcription R-HSA-9828642 4.725713e-01 0.326 0 0
Regulation of KIT signaling R-HSA-1433559 4.725713e-01 0.326 0 0
Zinc transporters R-HSA-435354 4.725713e-01 0.326 0 0
Signaling by FGFR4 in disease R-HSA-5655291 4.725713e-01 0.326 0 0
Elastic fibre formation R-HSA-1566948 4.748421e-01 0.323 0 0
SLC transporter disorders R-HSA-5619102 4.852124e-01 0.314 0 0
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 4.862649e-01 0.313 0 0
Late SARS-CoV-2 Infection Events R-HSA-9772573 4.901174e-01 0.310 0 0
Adenylate cyclase inhibitory pathway R-HSA-170670 4.909982e-01 0.309 0 0
RNA Polymerase III Chain Elongation R-HSA-73780 4.909982e-01 0.309 0 0
Processive synthesis on the lagging strand R-HSA-69183 4.909982e-01 0.309 0 0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513 4.909982e-01 0.309 0 0
Formation of the embryonic stem cell BAF (esBAF) complex R-HSA-9933946 4.909982e-01 0.309 0 0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385 4.909982e-01 0.309 0 0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767 4.909982e-01 0.309 0 0
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770 4.909982e-01 0.309 0 0
Other semaphorin interactions R-HSA-416700 4.909982e-01 0.309 0 0
Rab regulation of trafficking R-HSA-9007101 4.972214e-01 0.303 0 0
HIV Transcription Elongation R-HSA-167169 4.975316e-01 0.303 0 0
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 4.975316e-01 0.303 0 0
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 4.975316e-01 0.303 0 0
Nuclear signaling by ERBB4 R-HSA-1251985 4.975316e-01 0.303 0 0
Collagen formation R-HSA-1474290 5.051093e-01 0.297 0 0
VEGFR2 mediated vascular permeability R-HSA-5218920 5.086392e-01 0.294 0 0
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 5.086392e-01 0.294 0 0
Aberrant regulation of mitotic exit in cancer due to RB1 defects R-HSA-9687136 5.087824e-01 0.293 0 0
Class I peroxisomal membrane protein import R-HSA-9603798 5.087824e-01 0.293 0 0
WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.087824e-01 0.293 0 0
Receptor-type tyrosine-protein phosphatases R-HSA-388844 5.087824e-01 0.293 0 0
Prolonged ERK activation events R-HSA-169893 5.087824e-01 0.293 0 0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.087824e-01 0.293 0 0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.087824e-01 0.293 0 0
Attachment and Entry R-HSA-9678110 5.087824e-01 0.293 0 0
Telomere C-strand (Lagging Strand) Synthesis R-HSA-174417 5.195852e-01 0.284 0 0
Antigen processing: Ub, ATP-independent proteasomal degradation R-HSA-9912633 5.259464e-01 0.279 0 0
TRAF3-dependent IRF activation pathway R-HSA-918233 5.259464e-01 0.279 0 0
Fibronectin matrix formation R-HSA-1566977 5.259464e-01 0.279 0 0
Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141430 5.259464e-01 0.279 0 0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141405 5.259464e-01 0.279 0 0
SHC1 events in ERBB4 signaling R-HSA-1250347 5.259464e-01 0.279 0 0
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 5.259464e-01 0.279 0 0
Acetylcholine regulates insulin secretion R-HSA-399997 5.259464e-01 0.279 0 0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.259464e-01 0.279 0 0
Cytosolic tRNA aminoacylation R-HSA-379716 5.303671e-01 0.275 0 0
Nuclear Events (kinase and transcription factor activation) R-HSA-198725 5.409221e-01 0.267 0 0
TBC/RABGAPs R-HSA-8854214 5.409831e-01 0.267 0 0
Signaling by SCF-KIT R-HSA-1433557 5.409831e-01 0.267 0 0
Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.425115e-01 0.266 0 0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176407 5.425115e-01 0.266 0 0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.425115e-01 0.266 0 0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.425115e-01 0.266 0 0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes R-HSA-9851695 5.555037e-01 0.255 0 0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis R-HSA-9841922 5.555037e-01 0.255 0 0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes R-HSA-9818564 5.555037e-01 0.255 0 0
Ephrin signaling R-HSA-3928664 5.584988e-01 0.253 0 0
Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.584988e-01 0.253 0 0
Tie2 Signaling R-HSA-210993 5.584988e-01 0.253 0 0
Mismatch Repair R-HSA-5358508 5.584988e-01 0.253 0 0
Signaling by TGFBR3 R-HSA-9839373 5.718217e-01 0.243 0 0
Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167242 5.739284e-01 0.241 0 0
Signaling by FGFR2 IIIa TM R-HSA-8851708 5.739284e-01 0.241 0 0
Rap1 signalling R-HSA-392517 5.739284e-01 0.241 0 0
E2F mediated regulation of DNA replication R-HSA-113510 5.739284e-01 0.241 0 0
The NLRP3 inflammasome R-HSA-844456 5.739284e-01 0.241 0 0
O2/CO2 exchange in erythrocytes R-HSA-1480926 5.739284e-01 0.241 0 0
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 5.739284e-01 0.241 0 0
Strand-asynchronous mitochondrial DNA replication R-HSA-9913635 5.739284e-01 0.241 0 0
Other interleukin signaling R-HSA-449836 5.739284e-01 0.241 0 0
Signaling by NTRK1 (TRKA) R-HSA-187037 5.741839e-01 0.241 0 0
Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.817615e-01 0.235 0 0
Formation of ATP by chemiosmotic coupling R-HSA-163210 5.888196e-01 0.230 0 0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) R-HSA-9934037 5.888196e-01 0.230 0 0
VxPx cargo-targeting to cilium R-HSA-5620916 5.888196e-01 0.230 0 0
Wax and plasmalogen biosynthesis R-HSA-8848584 5.888196e-01 0.230 0 0
BBSome-mediated cargo-targeting to cilium R-HSA-5620922 5.888196e-01 0.230 0 0
Creatine metabolism R-HSA-71288 5.888196e-01 0.230 0 0
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.896034e-01 0.229 0 0
GPER1 signaling R-HSA-9634597 5.915304e-01 0.228 0 0
NGF-stimulated transcription R-HSA-9031628 5.915304e-01 0.228 0 0
Chemokine receptors bind chemokines R-HSA-380108 6.011284e-01 0.221 0 0
MyD88 deficiency (TLR2/4) R-HSA-5602498 6.031913e-01 0.220 0 0
ADP signalling through P2Y purinoceptor 12 R-HSA-392170 6.031913e-01 0.220 0 0
SHC-mediated cascade:FGFR3 R-HSA-5654704 6.031913e-01 0.220 0 0
Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 6.031913e-01 0.220 0 0
Zygotic genome activation (ZGA) R-HSA-9819196 6.031913e-01 0.220 0 0
Azathioprine ADME R-HSA-9748787 6.105553e-01 0.214 0 0
Signaling by FGFR2 in disease R-HSA-5655253 6.105553e-01 0.214 0 0
IRAK4 deficiency (TLR2/4) R-HSA-5603041 6.170615e-01 0.210 0 0
Mitochondrial calcium ion transport R-HSA-8949215 6.170615e-01 0.210 0 0
SHC-mediated cascade:FGFR4 R-HSA-5654719 6.170615e-01 0.210 0 0
FRS-mediated FGFR3 signaling R-HSA-5654706 6.170615e-01 0.210 0 0
Serine metabolism R-HSA-977347 6.170615e-01 0.210 0 0
Androgen biosynthesis R-HSA-193048 6.170615e-01 0.210 0 0
Attachment and Entry R-HSA-9694614 6.170615e-01 0.210 0 0
Signaling by NTRK3 (TRKC) R-HSA-9034015 6.170615e-01 0.210 0 0
RNA Polymerase II Transcription R-HSA-73857 6.224273e-01 0.206 0 0
Formation of RNA Pol II elongation complex R-HSA-112382 6.288972e-01 0.201 0 0
Neurexins and neuroligins R-HSA-6794361 6.288972e-01 0.201 0 0
FGFR2 alternative splicing R-HSA-6803529 6.304477e-01 0.200 0 0
RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-76071 6.304477e-01 0.200 0 0
FRS-mediated FGFR4 signaling R-HSA-5654712 6.304477e-01 0.200 0 0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439 6.304477e-01 0.200 0 0
RAF-independent MAPK1/3 activation R-HSA-112409 6.304477e-01 0.200 0 0
Signaling by KIT in disease R-HSA-9669938 6.304477e-01 0.200 0 0
RNA Polymerase II Transcription Elongation R-HSA-75955 6.378132e-01 0.195 0 0
Nucleotide biosynthesis R-HSA-8956320 6.378132e-01 0.195 0 0
Protein-protein interactions at synapses R-HSA-6794362 6.420298e-01 0.192 0 0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 6.433667e-01 0.192 0 0
RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 6.433667e-01 0.192 0 0
Formation of the ureteric bud R-HSA-9830674 6.433667e-01 0.192 0 0
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 6.433667e-01 0.192 0 0
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952 6.433667e-01 0.192 0 0
G alpha (z) signalling events R-HSA-418597 6.551392e-01 0.184 0 0
Leishmania phagocytosis R-HSA-9664417 6.555091e-01 0.183 0 0
FCGR3A-mediated phagocytosis R-HSA-9664422 6.555091e-01 0.183 0 0
Parasite infection R-HSA-9664407 6.555091e-01 0.183 0 0
CD209 (DC-SIGN) signaling R-HSA-5621575 6.558349e-01 0.183 0 0
SHC-mediated cascade:FGFR1 R-HSA-5654688 6.558349e-01 0.183 0 0
Replacement of protamines by nucleosomes in the male pronucleus R-HSA-9821993 6.558349e-01 0.183 0 0
Plasma lipoprotein assembly R-HSA-8963898 6.558349e-01 0.183 0 0
Complex III assembly R-HSA-9865881 6.558349e-01 0.183 0 0
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648 6.558349e-01 0.183 0 0
Interleukin-6 family signaling R-HSA-6783589 6.558349e-01 0.183 0 0
NRAGE signals death through JNK R-HSA-193648 6.635511e-01 0.178 0 0
SWI/SNF chromatin remodelers R-HSA-9932451 6.678679e-01 0.175 0 0
ATP-dependent chromatin remodelers R-HSA-9932444 6.678679e-01 0.175 0 0
Acyl chain remodelling of PS R-HSA-1482801 6.678679e-01 0.175 0 0
FRS-mediated FGFR1 signaling R-HSA-5654693 6.678679e-01 0.175 0 0
Hyaluronan degradation R-HSA-2160916 6.678679e-01 0.175 0 0
HDMs demethylate histones R-HSA-3214842 6.678679e-01 0.175 0 0
Generic Transcription Pathway R-HSA-212436 6.774322e-01 0.169 0 0
Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.794809e-01 0.168 0 0
TRP channels R-HSA-3295583 6.794809e-01 0.168 0 0
Myogenesis R-HSA-525793 6.794809e-01 0.168 0 0
Sphingolipid catabolism R-HSA-9845614 6.794809e-01 0.168 0 0
Synthesis of PIPs at the Golgi membrane R-HSA-1660514 6.794809e-01 0.168 0 0
Peptide hormone metabolism R-HSA-2980736 6.839844e-01 0.165 0 0
Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 6.877970e-01 0.163 0 0
PI3K/AKT Signaling in Cancer R-HSA-2219528 6.896510e-01 0.161 0 0
Processive synthesis on the C-strand of the telomere R-HSA-174414 6.906886e-01 0.161 0 0
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427 6.906886e-01 0.161 0 0
SHC-mediated cascade:FGFR2 R-HSA-5654699 6.906886e-01 0.161 0 0
Maturation of hRSV A proteins R-HSA-9828806 6.906886e-01 0.161 0 0
Signaling by FGFR3 in disease R-HSA-5655332 6.906886e-01 0.161 0 0
tRNA Aminoacylation R-HSA-379724 6.955538e-01 0.158 0 0
Bacterial Infection Pathways R-HSA-9824439 7.008772e-01 0.154 0 0
Formation of the HIV-1 Early Elongation Complex R-HSA-167158 7.015050e-01 0.154 0 0
Formation of the Early Elongation Complex R-HSA-113418 7.015050e-01 0.154 0 0
RUNX2 regulates osteoblast differentiation R-HSA-8940973 7.015050e-01 0.154 0 0
FRS-mediated FGFR2 signaling R-HSA-5654700 7.015050e-01 0.154 0 0
Inflammasomes R-HSA-622312 7.015050e-01 0.154 0 0
ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-380994 7.015050e-01 0.154 0 0
Pyroptosis R-HSA-5620971 7.015050e-01 0.154 0 0
Signaling by NTRKs R-HSA-166520 7.022173e-01 0.154 0 0
Synthesis of PIPs at the plasma membrane R-HSA-1660499 7.105892e-01 0.148 0 0
mRNA Capping R-HSA-72086 7.119438e-01 0.148 0 0
Regulation of gene expression in beta cells R-HSA-210745 7.119438e-01 0.148 0 0
Regulation of CDH11 Expression and Function R-HSA-9759475 7.119438e-01 0.148 0 0
Downstream signaling of activated FGFR3 R-HSA-5654708 7.119438e-01 0.148 0 0
DARPP-32 events R-HSA-180024 7.119438e-01 0.148 0 0
MITF-M-dependent gene expression R-HSA-9856651 7.119771e-01 0.148 0 0
Mitochondrial protein degradation R-HSA-9837999 7.145183e-01 0.146 0 0
Activation of the pre-replicative complex R-HSA-68962 7.220182e-01 0.141 0 0
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 7.220182e-01 0.141 0 0
Downstream signaling of activated FGFR4 R-HSA-5654716 7.220182e-01 0.141 0 0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 7.220182e-01 0.141 0 0
Neurotransmitter clearance R-HSA-112311 7.220182e-01 0.141 0 0
DAP12 signaling R-HSA-2424491 7.220182e-01 0.141 0 0
Regulation of insulin secretion R-HSA-422356 7.434994e-01 0.129 0 0
Regulation of TP53 Activity through Acetylation R-HSA-6804758 7.501794e-01 0.125 0 0
Activation of ATR in response to replication stress R-HSA-176187 7.501794e-01 0.125 0 0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 7.501794e-01 0.125 0 0
Regulation of Expression and Function of Type II Classical Cadherins R-HSA-9764260 7.501794e-01 0.125 0 0
Synthesis of IP3 and IP4 in the cytosol R-HSA-1855204 7.501794e-01 0.125 0 0
Transcription of the HIV genome R-HSA-167172 7.520002e-01 0.124 0 0
Collagen biosynthesis and modifying enzymes R-HSA-1650814 7.520002e-01 0.124 0 0
Acyl chain remodelling of PC R-HSA-1482788 7.589187e-01 0.120 0 0
EGR2 and SOX10-mediated initiation of Schwann cell myelination R-HSA-9619665 7.589187e-01 0.120 0 0
Fatty acyl-CoA biosynthesis R-HSA-75105 7.646249e-01 0.117 0 0
PI Metabolism R-HSA-1483255 7.649590e-01 0.116 0 0
Cardiac conduction R-HSA-5576891 7.660229e-01 0.116 0 0
eNOS activation R-HSA-203615 7.673527e-01 0.115 0 0
Regulation of TLR by endogenous ligand R-HSA-5686938 7.673527e-01 0.115 0 0
Hyaluronan metabolism R-HSA-2142845 7.673527e-01 0.115 0 0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-983170 7.673527e-01 0.115 0 0
Signal amplification R-HSA-392518 7.673527e-01 0.115 0 0
Glycosaminoglycan-protein linkage region biosynthesis R-HSA-1971475 7.673527e-01 0.115 0 0
Degradation of the extracellular matrix R-HSA-1474228 7.705485e-01 0.113 0 0
Metabolism of cofactors R-HSA-8978934 7.707256e-01 0.113 0 0
ECM proteoglycans R-HSA-3000178 7.707256e-01 0.113 0 0
Acyl chain remodelling of PE R-HSA-1482839 7.754922e-01 0.110 0 0
Downstream signaling of activated FGFR2 R-HSA-5654696 7.754922e-01 0.110 0 0
Downstream signaling of activated FGFR1 R-HSA-5654687 7.754922e-01 0.110 0 0
GPVI-mediated activation cascade R-HSA-114604 7.833474e-01 0.106 0 0
RUNX2 regulates bone development R-HSA-8941326 7.833474e-01 0.106 0 0
FGFR2 mutant receptor activation R-HSA-1839126 7.833474e-01 0.106 0 0
RNA Polymerase II Pre-transcription Events R-HSA-674695 7.882073e-01 0.103 0 0
Signaling by FGFR in disease R-HSA-1226099 7.882073e-01 0.103 0 0
TRAF6 mediated IRF7 activation R-HSA-933541 7.909282e-01 0.102 0 0
Ubiquinol biosynthesis R-HSA-2142789 7.909282e-01 0.102 0 0
Metabolism of folate and pterines R-HSA-196757 7.909282e-01 0.102 0 0
Integration of energy metabolism R-HSA-163685 7.921530e-01 0.101 0 0
Metabolism of nitric oxide: NOS3 activation and regulation R-HSA-202131 7.982443e-01 0.098 0 0
SLC-mediated transport of inorganic anions R-HSA-9958790 7.982443e-01 0.098 0 0
Transcriptional Regulation by E2F6 R-HSA-8953750 8.053047e-01 0.094 0 0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 8.053047e-01 0.094 0 0
Expression of BMAL (ARNTL), CLOCK, and NPAS2 R-HSA-9931509 8.053047e-01 0.094 0 0
Cell surface interactions at the vascular wall R-HSA-202733 8.069089e-01 0.093 0 0
Interleukin-10 signaling R-HSA-6783783 8.096849e-01 0.092 0 0
G alpha (12/13) signalling events R-HSA-416482 8.096849e-01 0.092 0 0
Transcriptional regulation of brown and beige adipocyte differentiation R-HSA-9843743 8.121185e-01 0.090 0 0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 R-HSA-9844594 8.121185e-01 0.090 0 0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 8.121185e-01 0.090 0 0
Diseases of Immune System R-HSA-5260271 8.121185e-01 0.090 0 0
Diseases associated with the TLR signaling cascade R-HSA-5602358 8.121185e-01 0.090 0 0
Generation of second messenger molecules R-HSA-202433 8.121185e-01 0.090 0 0
Mitochondrial tRNA aminoacylation R-HSA-379726 8.121185e-01 0.090 0 0
PKMTs methylate histone lysines R-HSA-3214841 8.186942e-01 0.087 0 0
Transcriptional Regulation by VENTX R-HSA-8853884 8.186942e-01 0.087 0 0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells R-HSA-9856530 8.196790e-01 0.086 0 0
RNA Polymerase II HIV Promoter Escape R-HSA-167162 8.250402e-01 0.084 0 0
HIV Transcription Initiation R-HSA-167161 8.250402e-01 0.084 0 0
RNA Polymerase II Transcription Initiation R-HSA-75953 8.250402e-01 0.084 0 0
Scavenging by Class A Receptors R-HSA-3000480 8.250402e-01 0.084 0 0
SLC-mediated transport of neurotransmitters R-HSA-442660 8.250402e-01 0.084 0 0
Signaling by FGFR1 in disease R-HSA-5655302 8.250402e-01 0.084 0 0
Aerobic respiration and respiratory electron transport R-HSA-1428517 8.252039e-01 0.083 0 0
Activation of GABAB receptors R-HSA-991365 8.311644e-01 0.080 0 0
GABA B receptor activation R-HSA-977444 8.311644e-01 0.080 0 0
Incretin synthesis, secretion, and inactivation R-HSA-400508 8.311644e-01 0.080 0 0
RNA Polymerase II Promoter Escape R-HSA-73776 8.370746e-01 0.077 0 0
Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 8.370746e-01 0.077 0 0
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 8.427782e-01 0.074 0 0
DAP12 interactions R-HSA-2172127 8.427782e-01 0.074 0 0
Mitochondrial biogenesis R-HSA-1592230 8.440606e-01 0.074 0 0
RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 8.482826e-01 0.071 0 0
Regulation of MITF-M-dependent genes involved in pigmentation R-HSA-9824585 8.482826e-01 0.071 0 0
ADORA2B mediated anti-inflammatory cytokines production R-HSA-9660821 8.482826e-01 0.071 0 0
Peptide ligand-binding receptors R-HSA-375276 8.528955e-01 0.069 0 0
Purinergic signaling in leishmaniasis infection R-HSA-9660826 8.535945e-01 0.069 0 0
Cell recruitment (pro-inflammatory response) R-HSA-9664424 8.535945e-01 0.069 0 0
Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 8.535945e-01 0.069 0 0
Metal ion SLC transporters R-HSA-425410 8.636679e-01 0.064 0 0
Plasma lipoprotein remodeling R-HSA-8963899 8.636679e-01 0.064 0 0
Formation of the cornified envelope R-HSA-6809371 8.679553e-01 0.062 0 0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 8.730493e-01 0.059 0 0
The phototransduction cascade R-HSA-2514856 8.774955e-01 0.057 0 0
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 8.840696e-01 0.054 0 0
Amino acids regulate mTORC1 R-HSA-9639288 8.859269e-01 0.053 0 0
Negative regulation of the PI3K/AKT network R-HSA-199418 8.885644e-01 0.051 0 0
Metabolism of nucleotides R-HSA-15869 8.917703e-01 0.050 0 0
Detoxification of Reactive Oxygen Species R-HSA-3299685 8.975002e-01 0.047 0 0
Dectin-2 family R-HSA-5621480 9.010914e-01 0.045 0 0
IRS-mediated signalling R-HSA-112399 9.010914e-01 0.045 0 0
FOXO-mediated transcription R-HSA-9614085 9.021734e-01 0.045 0 0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-HSA-9029569 9.045569e-01 0.044 0 0
Early SARS-CoV-2 Infection Events R-HSA-9772572 9.045569e-01 0.044 0 0
Regulation of beta-cell development R-HSA-186712 9.079013e-01 0.042 0 0
Parasitic Infection Pathways R-HSA-9824443 9.098819e-01 0.041 0 0
Leishmania infection R-HSA-9658195 9.098819e-01 0.041 0 0
GABA receptor activation R-HSA-977443 9.111286e-01 0.040 0 0
IRS-related events triggered by IGF1R R-HSA-2428928 9.142430e-01 0.039 0 0
Heme signaling R-HSA-9707616 9.172485e-01 0.038 0 0
Complex I biogenesis R-HSA-6799198 9.201488e-01 0.036 0 0
IGF1R signaling cascade R-HSA-2428924 9.229477e-01 0.035 0 0
Insulin receptor signalling cascade R-HSA-74751 9.229477e-01 0.035 0 0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 9.256486e-01 0.034 0 0
tRNA modification in the nucleus and cytosol R-HSA-6782315 9.282550e-01 0.032 0 0
Kidney development R-HSA-9830369 9.307702e-01 0.031 0 0
Metabolism of steroid hormones R-HSA-196071 9.307702e-01 0.031 0 0
FCERI mediated MAPK activation R-HSA-2871796 9.346585e-01 0.029 0 0
Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 9.375129e-01 0.028 0 0
Ca2+ pathway R-HSA-4086398 9.441166e-01 0.025 0 0
PPARA activates gene expression R-HSA-1989781 9.451055e-01 0.025 0 0
Regulation of lipid metabolism by PPARalpha R-HSA-400206 9.478956e-01 0.023 0 0
NR1H2 and NR1H3-mediated signaling R-HSA-9024446 9.515542e-01 0.022 0 0
Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 9.548937e-01 0.020 0 0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 9.554393e-01 0.020 0 0
Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 9.580034e-01 0.019 0 0
Adipogenesis R-HSA-9843745 9.669548e-01 0.015 0 0
G alpha (i) signalling events R-HSA-418594 9.680054e-01 0.014 0 0
Signaling by Insulin receptor R-HSA-74752 9.736081e-01 0.012 0 0
Transcriptional regulation of white adipocyte differentiation R-HSA-381340 9.779285e-01 0.010 0 0
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 9.779285e-01 0.010 0 0
Synthesis of bile acids and bile salts R-HSA-192105 9.801738e-01 0.009 0 0
Arachidonate metabolism R-HSA-2142753 9.835955e-01 0.007 0 0
Keratinization R-HSA-6805567 9.869834e-01 0.006 0 0
Bile acid and bile salt metabolism R-HSA-194068 9.870945e-01 0.006 0 0
FCERI mediated Ca+2 mobilization R-HSA-2871809 9.899552e-01 0.004 0 0
G alpha (q) signalling events R-HSA-416476 9.907503e-01 0.004 0 0
G alpha (s) signalling events R-HSA-418555 9.911847e-01 0.004 0 0
Leishmania parasite growth and survival R-HSA-9664433 9.917200e-01 0.004 0 0
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851 9.917200e-01 0.004 0 0
Glycosaminoglycan metabolism R-HSA-1630316 9.955957e-01 0.002 0 0
GPCR downstream signalling R-HSA-388396 9.959395e-01 0.002 0 0
Phospholipid metabolism R-HSA-1483257 9.959934e-01 0.002 0 0
Visual phototransduction R-HSA-2187338 9.972365e-01 0.001 0 0
Drug ADME R-HSA-9748784 9.980838e-01 0.001 0 0
Diseases of metabolism R-HSA-5668914 9.986819e-01 0.001 0 0
Class A/1 (Rhodopsin-like receptors) R-HSA-373076 9.990640e-01 0.000 0 0
Respiratory electron transport R-HSA-611105 9.991246e-01 0.000 0 0
Signaling by GPCR R-HSA-372790 9.991979e-01 0.000 0 0
Metabolism of steroids R-HSA-8957322 9.996054e-01 0.000 0 0
Sphingolipid metabolism R-HSA-428157 9.996174e-01 0.000 0 0
Glycerophospholipid biosynthesis R-HSA-1483206 9.996440e-01 0.000 0 0
Transport of small molecules R-HSA-382551 9.996947e-01 0.000 0 0
Phase I - Functionalization of compounds R-HSA-211945 9.997302e-01 0.000 0 0
Fatty acid metabolism R-HSA-8978868 9.998435e-01 0.000 0 0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 9.998655e-01 0.000 0 0
Metabolism of water-soluble vitamins and cofactors R-HSA-196849 9.998703e-01 0.000 0 0
Metabolism of vitamins and cofactors R-HSA-196854 9.998864e-01 0.000 0 0
SLC-mediated transmembrane transport R-HSA-425407 9.999613e-01 0.000 0 0
GPCR ligand binding R-HSA-500792 9.999967e-01 0.000 0 0
Biological oxidations R-HSA-211859 9.999999e-01 0.000 0 0
Metabolism R-HSA-1430728 1.000000e+00 0.000 0 0
Metabolism of lipids R-HSA-556833 1.000000e+00 0.000 0 0
Sensory Perception R-HSA-9709957 1.000000e+00 0.000 0 0
Top15 pathways (red highlights are reference pathways)
Compared with reference pathways