ATM

Normalized values from positional scanning peptide array

Phospho-serine (pS) is a duplicate of phospho-tyrosine (pT) in PSPA

Position-wise Probabilities

Log-Odds: Probabilities / STY Background

Sites with acceptor types representing >8% and count ≥10 are included

S Sites Probabilities

T Sites Probabilities

Log-Odds: S Sites / S Background

Log-Odds: T Sites / T Background

Sites with acceptor types representing >8% and count ≥10 are included

Download Data Table

Motif clusters with count ≥ 10 are shown

Download

substrate_uniprot	site	source	substrate_genes	site_seq
O00213	S228	PSP	APBB1 FE65 RIR	LLFGMRNSAASDEDSSWATLsQGSPSYGSPEDTDSFWNPNA
O00255	S394	PSP	MEN1 SCG2	NLLKEAASLLEAGEERPGEQsQGTQSQGSALQDPECFAHLL
O14757	S317	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	CHEK1 CHK1	NLDFsPVNsAssEENVKYsssQPEPRTGLsLWDtsPsYIDK
O14757	S345	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CHEK1 CHK1	LsLWDtsPsYIDKLVQGISFsQPTCPDHMLLNSQLLGTPGS
O15111	S473	PSP	CHUK IKKA TCF16	LSLLRYNANLTKMKNTLISAsQQLKAKLEFFHKSIQLDLER
O15151	S342	SIGNOR	MDM4 MDMX	RCWALRKDWYSDCSKLtHsLstsDItAIPEKENEGNDVPDC
O15151	S367	SIGNOR	MDM4 MDMX	tAIPEKENEGNDVPDCRRtIsAPVVRPKDAYIKKENSKLFD
O15151	S403	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	MDM4 MDMX	SKLFDPCNSVEFLDLAHSSEsQETISSMGEQLDNLSEQRTD
O15164	S217	PSP	TRIM24 RNF82 TIF1 TIF1A	TKDHTVRQKEEVsPEAVGVTsQRPVFCPFHKKEQLKLYCET
O15164	S768	PSP	TRIM24 RNF82 TIF1 TIF1A	SRPQNANYPRSILtsLLLNssQsstsEETVLRSDAPDSTGD
O15164	S808	PSP	TRIM24 RNF82 TIF1 TIF1A	DQPGLHQDNSsNGKsEWLDPsQKsPLHVGETRKEDDPNEDW
O15355	S183	SIGNOR\|EPSD\|PSP	PPM1G PPM1C	NCHKGPPHSKsGGGtGEEPGsQGLNGEAGPEDstREtPsQE
O15360	S1449	SIGNOR	FANCA FAA FACA FANCH	DPEVSAALQSRQQAAPDADLsQEPHLF______________
O43504	S26	EPSD\|PSP	LAMTOR5 HBXIP XIP	EQHLEDTMKNPSIVGVLCtDsQGLNLGCRGTLSDEHAGVIS
O43670	S104	PSP	ZNF207 BUGZ	GIPEKDMDERRRLLEQKTQEsQKKKQQDDSDEYDDDDSAAS
O43683	S314	SIGNOR\|EPSD\|PSP	BUB1 BUB1L	DELHKKLHQVVEtsHEDLPAsQERsEVNPARMGPSVGsQQE
O43684	S135	SIGNOR\|PSP	BUB3	SWDQTVKLWDPRtPCNAGTFsQPEKVytLSVSGDRLIVGTA
O43791	S119	PSP	SPOP	RAKFKFSILNAKGEETKAMEsQRAYRFVQGKDWGFKKFIRR
O60934	S278	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	NBN NBS NBS1 P95	EEHNFFLAPGTCVVDTGITNsQTLIPDCQKKWIQSIMDMLQ
O60934	S343	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	NBN NBS NBS1 P95	CDPQGHPSTGLKtttPGPsLsQGVsVDEKLMPSAPVNTTTY
O60934	S397	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	NBN NBS NBS1 P95	LSERPKEIKVSKMEQKFRMLsQDAPTVKESCKtssNNNSMV
O60934	S615	SIGNOR\|EPSD\|PSP	NBN NBS NBS1 P95	MDIETNDtFsDEAVPEssKIsQENEIGKKRELKEDSLWSAK
O75150	S114	SIGNOR\|EPSD\|PSP	RNF40 BRE1B KIAA0661	VNRYWAQLDETVEALLRCHEsQGELSSAPEAPGTQEGPTCD
O75150	S819	EPSD\|PSP	RNF40 BRE1B KIAA0661	IHKLLREEKDELGEQVLGLKsQVDAQLLTVQKLEEKERALQ
O75150	S853	EPSD\|PSP	RNF40 BRE1B KIAA0661	EKERALQGSLGGVEKELTLRsQALELNKRKAVEAAQLAEDL
O75943	S646	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RAD17 R24L	EESLGEPtQATVPETWSLPLsQNSASELPAsQPQPFSAQGD
O75943	S656	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RAD17 R24L	TVPETWSLPLsQNSASELPAsQPQPFSAQGDMEENIIIEDy
O75943	T633	PSP	RAD17 R24L	SGDEAQLNGGHSAEESLGEPtQATVPETWSLPLsQNSASEL
O94874	S462	GPS6\|SIGNOR\|PSP	UFL1 KIAA0776 MAXER NLBP RCAD	EYKIKKVKKKGRKDDDsDDEsQSSHTGKKKPEISFMFQDEI
O94916	S1197	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	NFAT5 KIAA0827 TONEBP	EQQAAFQQQAPISHIQTPMLsQEQAQPPQQGLFQPQVALGS
O94916	S1247	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	NFAT5 KIAA0827 TONEBP	QQGTMFQSQHSIVAMQSNSPsQEQQQQQQQQQQQQQQQQQS
O94916	S1367	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	NFAT5 KIAA0827 TONEBP	SQTPLFHSSPQIQLVQGSPSsQEQQVTLFLSPASMSALQTS
O95071	S1532	EPSD\|PSP	UBR5 EDD EDD1 HYD KIAA0896	ELFSVEPLPPRPSSDQSSSSsQSQSSYIIRNPQQRRIsQsQ
O95071	S1679	EPSD\|PSP	UBR5 EDD EDD1 HYD KIAA0896	AFFSEDDSQSNDSSDSDSSSsQSDDIEQETFMLDEPLERTt
O95071	S174	EPSD\|PSP	UBR5 EDD EDD1 HYD KIAA0896	SRRQTRVIRTGRDRGsGLLGsQPQPVIPASVIPEELIsQAQ
O95071	S191	EPSD\|PSP	UBR5 EDD EDD1 HYD KIAA0896	LLGsQPQPVIPASVIPEELIsQAQVVLQGKsRsVIIRELQR
O95071	S2586	EPSD\|PSP	UBR5 EDD EDD1 HYD KIAA0896	HDFAFFDPVMYESLRQLILAsQSSDADAVFSAMDLAFAIDL
O96017	S19	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	CHEK2 CDS1 CHK2 RAD53	__MSRESDVEAQQSHGSSACsQPHGSVtQsQGSSsQsQGIS
O96017	S28	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CHEK2 CDS1 CHK2 RAD53	EAQQSHGSSACsQPHGSVtQsQGSSsQsQGISSSSTSTMPN
O96017	S33	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CHEK2 CDS1 CHK2 RAD53	HGSSACsQPHGSVtQsQGSSsQsQGISSSSTSTMPNSsQSS
O96017	S35	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CHEK2 CDS1 CHK2 RAD53	SSACsQPHGSVtQsQGSSsQsQGISSSSTSTMPNSsQSSHS
O96017	S50	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	CHEK2 CDS1 CHK2 RAD53	GSSsQsQGISSSSTSTMPNSsQSSHSSSGTLSsLETVStQE
O96017	T26	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CHEK2 CDS1 CHK2 RAD53	DVEAQQSHGSSACsQPHGSVtQsQGSSsQsQGISSSSTSTM
O96017	T68	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	CHEK2 CDS1 CHK2 RAD53	NSsQSSHSSSGTLSsLETVStQELYsIPEDQEPEDQEPEEP
O96028	S102	EPSD\|PSP	NSD2 KIAA1090 MMSET TRX5 WHSC1	LTSRVFNGEPGAHDAKLRFEsQEMKGIGtPPNttPIKNGsP
P00519	S446	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	ABL1 ABL JTK7	GVLLWEIATYGMSPYPGIDLsQVYELLEKDYRMERPEGCPE
P04637	S15	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TP53 P53	______MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPL
P04637	S20	SIGNOR\|iPTMNet\|EPSD\|PSP	TP53 P53	_MEEPQsDPsVEPPLsQEtFsDLWKLLPENNVLsPLPsQAM
P04637	S33	iPTMNet\|PSP	TP53 P53	PLsQEtFsDLWKLLPENNVLsPLPsQAMDDLMLsPDDIEQW
P04637	S37	iPTMNet\|PSP	TP53 P53	EtFsDLWKLLPENNVLsPLPsQAMDDLMLsPDDIEQWFtED
P04637	S46	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TP53 P53	LPENNVLsPLPsQAMDDLMLsPDDIEQWFtEDPGPDEAPRM
P04637	S9	SIGNOR\|iPTMNet	TP53 P53	____________MEEPQsDPsVEPPLsQEtFsDLWKLLPEN
P07900	T5	EPSD\|PSP	HSP90AA1 HSP90A HSPC1 HSPCA	________________MPEEtQtQDQPMEEEEVETFAFQAE
P07900	T7	EPSD\|PSP	HSP90AA1 HSP90A HSPC1 HSPCA	______________MPEEtQtQDQPMEEEEVETFAFQAEIA
P08047	S101	GPS6\|SIGNOR\|EPSD\|PSP	SP1 TSFP1	SQGPSQSGGTGELDLTATQLsQGANGWQIISSSSGATPTSK
P08047	S56	EPSD\|PSP	SP1 TSFP1	sQARssstGsssstGGGGQEsQPsPLALLAATCSRIESPNE
P11166	S490	PSP	SLC2A1 GLUT1	GGAsQsDKtPEELFHPLGADsQV__________________
P12956	S27	SIGNOR\|EPSD\|PSP	XRCC6 G22P1	YYKtEGDEEAEEEQEENLEAsGDyKYsGRDsLIFLVDASKA
P12956	S33	SIGNOR\|EPSD\|PSP	XRCC6 G22P1	DEEAEEEQEENLEAsGDyKYsGRDsLIFLVDASKAMFEsQS
P14618	T328	PSP	PKM OIP3 PK2 PK3 PKM2	LAQKMMIGRCNRAGKPVICAtQMLEsMIKKPRPTRAEGsDV
P15336	S490	GPS6\|SIGNOR\|EPSD\|PSP	ATF2 CREB2 CREBP1	EAVATSVLTQMADQSTEPALsQIVMAPSsQSQPSGS_____
P15336	S498	GPS6\|SIGNOR\|EPSD\|PSP	ATF2 CREB2 CREBP1	TQMADQSTEPALsQIVMAPSsQSQPSGS_____________
P15374	S75	SIGNOR\|EPSD\|PSP	UCHL3	LFPITEKYEVFRTEEEEKIKsQGQDVTSSVYFMKQTISNAC
P15927	S23	EPSD\|PSP	RPA2 REPA2 RPA32 RPA34	NsGFEsYGsssYGGAGGYtQsPGGFGsPAPsQAEKKSRARA
P15927	S29	EPSD\|PSP	RPA2 REPA2 RPA32 RPA34	YGsssYGGAGGYtQsPGGFGsPAPsQAEKKSRARAQHIVPC
P15927	T21	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RPA2 REPA2 RPA32 RPA34	MWNsGFEsYGsssYGGAGGYtQsPGGFGsPAPsQAEKKSRA
P16104	S140	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	H2AX H2AFX	KtsAtVGPKAPSGGKKAtQAsQEy_________________
P16220	S107	SIGNOR\|PSP	CREB1	QISTIAEsEDsQEsVDsVTDsQKRREILsRRPsYRKILNDL
P16220	S119	PSP	CREB1	EsVDsVTDsQKRREILsRRPsYRKILNDLssDAPGVPRIEE
P16220	S97	SIGNOR\|PSP	CREB1	VIQSPQVQTVQISTIAEsEDsQEsVDsVTDsQKRREILsRR
P20823	S249	SIGNOR\|PSP	HNF1A TCF1	RETLVEECNRAECIQRGVsPsQAQGLGSNLVTEVRVYNWFA
P22681	S866	PSP	CBL CBL2 RNF55	PAASAATASPQLSSEIENLMsQGYSYQDIQKALVIAQNNIE
P22681	T640	PSP	CBL CBL2 RNF55	LPFsLPSQMEPRPDVPRLGstFsLDtsMsMNssPLVGPECD
P23025	S173	SIGNOR\|iPTMNet\|EPSD\|PSP	XPA XPAC	CDLEKREPPLKFIVKKNPHHsQWGDMKLYLKLQIVKRSLEV
P23025	S196	SIGNOR\|iPTMNet\|EPSD\|PSP	XPA XPAC	GDMKLYLKLQIVKRSLEVWGsQEALEEAKEVRQENREKMKQ
P23919	S88	PSP	DTYMK CDC8 TMPK TYMK	VHLLFSANRWEQVPLIKEKLsQGVTLVVDRYAFSGVAFTGA
P25205	S535	GPS6\|SIGNOR\|EPSD\|PSP	MCM3	GDAMPLGSAVDILATDDPNFsQEDQQDTQIYEKHDNLLHGT
P27707	S74	SIGNOR\|EPSD\|PSP	DCK	PVARWCNVQstQDEFEELtMsQKNGGNVLQMMYEKPERWSF
P31749	S473	EPSD	AKT1 PKB RAC	DQDDSMECVDSERRPHFPQFsysAsGtA_____________
P35637	S42	EPSD\|PSP	FUS TLS	GQGYsQQSsQPYGQQSYSGYsQSTDTSGYGQSsYSSYGQsQ
P37275	S585	PSP	ZEB1 AREB6 TCF8	EAEKPEssVssAtGDGNLsPsQPPLKNLLSLLKAYYALNAQ
P38398	S1189	EPSD\|PSP	BRCA1 RNF53	DIKESsAVFSKsVQKGELsRsPsPFtHTHLAQGYRRGAKKL
P38398	S1330	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	BRCA1 RNF53	TNTQDPFLIGSSKQMRHQsEsQGVGLsDKELVsDDEERGTG
P38398	S1387	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	BRCA1 RNF53	EAASGCESETSVSEDCSGLSsQSDILTtQQRDTMQHNLIKL
P38398	S1423	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	BRCA1 RNF53	NLIKLQQEMAELEAVLEQHGsQPSNSYPSIISDSSALEDLR
P38398	S1457	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	BRCA1 RNF53	SALEDLRNPEQSTSEKAVLtsQKssEYPIsQNPEGLsADKF
P38398	S1466	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	BRCA1 RNF53	EQSTSEKAVLtsQKssEYPIsQNPEGLsADKFEVsADssTs
P38398	S1497	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	BRCA1 RNF53	FEVsADssTsKNKEPGVERssPSKCPsLDDRWYMHSCsGSL
P38398	S1524	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	BRCA1 RNF53	LDDRWYMHSCsGSLQNRNyPsQEELIKVVDVEEQQLEEsGP
P38398	S1542	SIGNOR\|EPSD\|PSP	BRCA1 RNF53	yPsQEELIKVVDVEEQQLEEsGPHDLtEtsyLPRQDLEGTP
P40692	S406	EPSD\|PSP	MLH1 COCA2	TDsREQKLDAFLQPLsKPLssQPQAIVTEDKTDISSGRARQ
P41236	S44	GPS6\|SIGNOR\|EPSD\|PSP	PPP1R2 IPP2	sMVAsAEQPRGNVDEELSKKsQKWDEMNILAtyHPADKDyG
P43243	S208	PSP	MATR3 KIAA0723	sFDDRGPsLNPVLDyDHGsRsQEsGyyDRMDyEDDRLRDGE
P46379	S218	EPSD\|PSP	BAG6 BAT3 G3	QHSQPPPQPPAVtPEPVALSsQTSEPVESEAPPREPMEAEE
P46379	S26	EPSD\|PSP	BAG6 BAT3 G3	stSTAVEEPDSLEVLVKTLDsQTRTFIVGAQMNVKEFKEHI
P46527	S140	EPSD\|PSP	CDKN1B KIP1 p27	GAPANSEDTHLVDPKTDPsDsQTGLAEQCAGIRKRPAtDDS
P46937	Y391	PSP	YAP1 YAP65	sQELRTMttNssDPFLNsGtyHsRDEstDsGLsMssysVPR
P49591	S101	PSP	SARS1 SARS SERS	PENVLSFDDLTADALANLKVsQIKKVRLLIDEAILKCDAER
P49591	S241	PSP	SARS1 SARS SERS	IPIYTPFFMRKEVMQEVAQLsQFDEELyKVIGKGSEKSDDN
P49917	S199	GPS6\|ELM\|iPTMNet\|EPSD	LIG4	SALEQKWLIRMIIKDLKLGVsQQTIFSVFHNDAAELHNVTT
P49959	S264	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MRE11 HNGS1 MRE11A	GHEHECKIAPTKNEQQLFYIsQPGssVVtsLsPGEAVKKHV
P49959	S676	EPSD\|PSP	MRE11 HNGS1 MRE11A	FPTTSKTDQRWSSTSSSKIMsQsQVsKGVDFEssEDDDDDP
P49959	S678	EPSD\|PSP	MRE11 HNGS1 MRE11A	TTSKTDQRWSSTSSSKIMsQsQVsKGVDFEssEDDDDDPFM
P50542	S141	SIGNOR\|EPSD\|PSP	PEX5 PXR1	EFLAAGDAVDVTQDYNETDWsQEFISEVTDPLSVSPARWAE
P51532	S721	EPSD\|PSP	SMARCA4 BAF190A BRG1 SNF2B SNF2L4	VDARHIIENAKQDVDDEyGVsQALARGLQSyyAVAHAVTER
P54132	T122	GPS6\|EPSD\|PSP	BLM RECQ2 RECQL3	GGSKSLLPDFLQtPKEVVCTtQNtPtVKKSRDTALKKLEFs
P54132	T99	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	BLM RECQ2 RECQL3	NTTNQQRVKDFFKNAPAGQEtQRGGSKSLLPDFLQtPKEVV
P54274	S219	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TERF1 PIN2 TRBF1 TRF TRF1	RIFGDPNSHMPFKSKLLMIIsQKDTFHSFFQHFSYNHMMEK
P54274	S367	PSP	TERF1 PIN2 TRBF1 TRF TRF1	STKKKKESRRAtESRIPVSKsQPVtPEKHRARKRQAWLWEE
P54646	T172	SIGNOR\|PSP	PRKAA2 AMPK AMPK2	NAKIADFGLSNMMsDGEFLRtsCGsPNyAAPEVISGRLYAG
P55072	S326	EPSD\|PSP	VCP HEL-220 HEL-S-70	LDAIAPKREKTHGEVERRIVsQLLTLMDGLKQRAHVIVMAA
P60484	S113	EPSD\|PSP	PTEN MMAC1 TEP1	HNPPQLELIKPFCEDLDQWLsEDDNHVAAIHCKAGKGRTGV
P60484	T398	EPSD\|PSP	PTEN MMAC1 TEP1	RYsDttDsDPENEPFDEDQHtQItKV_______________
P78527	S2612	EPSD\|PSP	PRKDC HYRC HYRC1	DSDWRFRSTVLtPMFVEtQAsQGtLQtRtQEGsLSARWPVA
P78527	S3205	PSP	PRKDC HYRC HYRC1	NRCFFLSKIEEKLtPLPEDNsMNVDQDGDPsDRMEVQEQEE
P78527	T2609	SIGNOR\|EPSD\|PSP	PRKDC HYRC HYRC1	YTIDSDWRFRSTVLtPMFVEtQAsQGtLQtRtQEGsLSARW
P78527	T2638	EPSD\|PSP	PRKDC HYRC HYRC1	tRtQEGsLSARWPVAGQIRAtQQQHDFtLtQtADGRssFDW
P78527	T2647	EPSD\|PSP	PRKDC HYRC HYRC1	ARWPVAGQIRAtQQQHDFtLtQtADGRssFDWLTGsstDPL
Q00987	S386	SIGNOR\|EPSD\|PSP	MDM2	IVNDSREsCVEENDDKITQAsQSQESEDysQPSTSsSIIyS
Q00987	S395	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	MDM2	VEENDDKITQAsQSQESEDysQPSTSsSIIySsQEDVKEFE
Q00987	S401	iPTMNet	MDM2	KITQAsQSQESEDysQPSTSsSIIySsQEDVKEFEREEtQD
Q00987	S407	PSP	MDM2	QSQESEDysQPSTSsSIIySsQEDVKEFEREEtQDKEEsVE
Q00987	S425	PSP	MDM2	ySsQEDVKEFEREEtQDKEEsVESsLPLNAIEPCVICQGRP
Q00987	S429	SIGNOR\|EPSD\|PSP	MDM2	EDVKEFEREEtQDKEEsVESsLPLNAIEPCVICQGRPKNGC
Q00987	T419	PSP	MDM2	TSsSIIySsQEDVKEFEREEtQDKEEsVESsLPLNAIEPCV
Q01094	S31	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	E2F1 RBBP3	PCAPALEALLGAGALRLLDSsQIVIISAAQDASAPPAPTGP
Q01844	T79	EPSD\|PSP	EWSR1 EWS	ATYGQTAYATSYGQPPTGYttPtAPQAYSQPVQGYGTGAYD
Q02535	S65	EPSD\|PSP	ID3 1R21 BHLHB25 HEIR1	NHCySRLRELVPGVPRGTQLsQVEILQRVIDYILDLQVVLA
Q02880	S1135	SIGNOR	TOP2B	QEKAAEEDETQNQHDDSsSDsGTPSGPDFNYILNMSLWSLT
Q03111	S394	EPSD\|PSP	MLLT1 ENL LTG19 YEATS1	SSPSNSSSSSDSSSDSDFEPsQNHsQGPLRSMVEDLQsEEs
Q03111	S398	EPSD\|PSP	MLLT1 ENL LTG19 YEATS1	NSSSSSDSSSDSDFEPsQNHsQGPLRSMVEDLQsEEsDEDD
Q03112	S1037	SIGNOR	MECOM EVI1 MDS1 PRDM3	DKEDAYFTEIRNFIGNSNHGsQsPRNVEERMNGSHFKDEKA
Q03112	S1039	SIGNOR	MECOM EVI1 MDS1 PRDM3	EDAYFTEIRNFIGNSNHGsQsPRNVEERMNGSHFKDEKALV
Q07666	S388	PSP	KHDRBS1 SAM68	EYGYDDTYAEQSYEGYEGYYsQsQGDSEYYDYGHGEVQDSY
Q07666	S390	PSP	KHDRBS1 SAM68	GYDDTYAEQSYEGYEGYYsQsQGDSEYYDYGHGEVQDSYEA
Q07666	T61	PSP	KHDRBS1 SAM68	PHRSRGGGGGSRGGARAsPAtQPPPLLPPSAtGPDATVGGP
Q09472	S106	SIGNOR\|EPSD\|PSP	EP300 P300	RsGssPNLNMGVGGPGQVMAsQAQQSSPGLGLINSMVKSPM
Q12888	S1219	SIGNOR\|EPSD\|PSP	TP53BP1	ERGsGEKPVsAPGDDtEsLHsQGEEEFDMPQPPHGHVLHRH
Q12888	S1778	EPSD\|PSP	TP53BP1	ssEEEEEFLEIPPFNKQYTEsQLRAGAGYILEDFNEAQCNT
Q12888	S25	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TP53BP1	GsQLDSDFSQQDTPCLIIEDsQPEsQVLEDDSGSHFSMLSR
Q12888	S29	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	TP53BP1	DSDFSQQDTPCLIIEDsQPEsQVLEDDSGSHFSMLSRHLPN
Q12888	S6	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	TP53BP1	_______________MDPTGsQLDSDFSQQDTPCLIIEDsQ
Q12888	S784	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	TP53BP1	PsPRVDVsCEPLEGVEKCsDsQsWEDIAPEIEPCAENRLDt
Q12888	S831	SIGNOR	TP53BP1	EYEGDLKsGtAEtEPVEQDssQPsLPLVRADDPLRLDQELQ
Q12888	T302	SIGNOR	TP53BP1	QELMEsGLQIQKsPEPEVLstQEDLFDQsNKtVssDGCstP
Q13098	S474	EPSD\|PSP	GPS1 COPS1 CSN1	MLRAAVLRNQIHVKsPPREGsQGELtPANsQsRMstNM___
Q13263	S824	GPS6\|EPSD\|PSP	TRIM28 KAP1 RNF96 TIF1B	KFSAVLVEPPPMsLPGAGLssQELsGGPGDGP_________
Q13315	S1893	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	ATM	CLRHFsQtsRsttPANLDsEsEHFFRCCLDKKSQRTMLAVV
Q13315	S1981	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	ATM	YADKKSMDDQEKRSLAFEEGsQSTtIssLSEKsKEETGISL
Q13315	S1987	iPTMNet	ATM	MDDQEKRSLAFEEGsQSTtIssLSEKsKEETGISLQDLLLE
Q13315	S2996	GPS6\|SIGNOR\|EPSD\|PSP	ATM	DETELHPTLNADDQECKRNLsDIDQSFNKVAERVLMRLQEK
Q13315	S367	GPS6\|SIGNOR\|iPTMNet\|EPSD\|PSP	ATM	ELMADICHQVFNEDTRSLEIsQSyTttQRESSDYSVPCKRK
Q13315	S440	SIGNOR\|iPTMNet\|EPSD\|PSP	ATM	ISKYPASLPNCELSPLLMILsQLLPQQRHGERTPYVLRCLT
Q13315	T1885	GPS6\|EPSD\|PSP	ATM	HVQGFFTSCLRHFsQtsRsttPANLDsEsEHFFRCCLDKKS
Q13362	S520	SIGNOR\|EPSD\|PSP	PPP2R5C KIAA0044	PQDPHTKKALEAHCRADELAsQDGR________________
Q13535	T1989	GPS6	ATR FRP1	VHQALIVLQKGVELCFPENEtPPEGKNMLIHGRAMLLVGRF
Q13541	S112	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	EIF4EBP1	EAsQsHLRNsPEDKRAGGEEsQFEMDI______________
Q13541	S8	GPS6\|ELM\|iPTMNet\|EPSD	EIF4EBP1	_____________MsGGssCsQtPSRAIPATRRVVLGDGVQ
Q13541	S94	EPSD\|PSP	EIF4EBP1	DLPtIPGVtsPssDEPPMEAsQsHLRNsPEDKRAGGEEsQF
Q13769	S307	PSP	THOC5 C22orf19 KIAA0983	SVAIEGSVDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRP
Q13769	S312	PSP	THOC5 C22orf19 KIAA0983	GSVDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQ
Q13769	S314	PSP	THOC5 C22orf19 KIAA0983	VDEAKALFKPPEDsQDDEsDsDAEEEQttKRRRPtLGVQLD
Q14161	S384	EPSD\|PSP	GIT2 KIAA0148	GsKDNVELILKTINNQHSVEsQDNDQPDyDsVAsDEDtDLE
Q14161	T195	EPSD\|PSP	GIT2 KIAA0148	SKAGQILQAELLAVYGADPGtQDSSGKTPVDYARQGGHHEL
Q14190	S115	PSP	SIM2 BHLHE15	VASDGKIMYISETASVHLGLsQVELTGNSIYEYIHPSDHDE
Q14191	S1141	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	WRN RECQ3 RECQL2	GSNISKKsIMVQsPEKAySSsQPVISAQEQETQIVLYGKLV
Q14191	S1292	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	WRN RECQ3 RECQL2	PLKSIAESRILPLMTIGMHLsQAVKAGCPLDLERAGLTPEV
Q14247	S113	PSP	CTTN EMS1	DRMDKsAVGHEyQSKLsKHCsQVDsVRGFGGKFGVQMDRVD
Q14457	T57	PSP	BECN1 GT197	VTIQELTAPLLTTAQAKPGEtQEEEtNsGEEPFIETPRQDG
Q14526	S713	PSP	HIC1 ZBTB29	PLAKFTAELGLsPDKAAEVLsQGAHLAAGPDGRtIDRFsPt
Q14674	S1660	PSP	ESPL1 ESP1 KIAA0165	LSKAQKHRGSLEIADQLQGLsLQEMPGDVPLARIQRLFSFR
Q14676	T4	EPSD\|PSP	MDC1 KIAA0170 NFBD1	_________________MEDtQAIDWDVEEEEETEQsSESL
Q14676	T98	EPSD\|PSP	MDC1 KIAA0170 NFBD1	IEILAWDKAPILRDCGSLNGtQILRPPKVLsPGVSHRLRDQ
Q14683	S957	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	SMC1A DXS423E KIAA0178 SB1.8 SMC1 SMC1L1	DIKLPLSKGtMDDIsQEEGssQGEDsVsGsQRIssIYAREA
Q14683	S966	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	SMC1A DXS423E KIAA0178 SB1.8 SMC1 SMC1L1	tMDDIsQEEGssQGEDsVsGsQRIssIYAREALIEIDYGDL
Q14694	S337	GPS6\|SIGNOR\|EPSD\|PSP	USP10 KIAA0190	PESASPPADGTGSASGTLPVsQPKsWASLFHDSKPssssPV
Q14694	T42	GPS6\|SIGNOR\|EPSD\|PSP	USP10 KIAA0190	FVtPRssVELPPYSGTVLCGtQAVDKLPDGQEYQRIEFGVD
Q14839	S1349	EPSD\|PSP	CHD4	LARNLGKGKRIRKQVNYNDGsQEDRDWQDDQSDNQSDYSVA
Q15109	S391	EPSD\|PSP	AGER RAGE	EERKAPENQEEEEERAELNQsEEPEAGEssTGGP_______
Q15648	S1134	EPSD\|PSP	MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2	MKSSKSEGSSSSKLSssMYSsQGssGssQsKNSsQsGGKPG
Q15648	S1141	EPSD\|PSP	MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2	GSSSSKLSssMYSsQGssGssQsKNSsQsGGKPGssPItKH
Q15648	S1147	EPSD\|PSP	MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2	LSssMYSsQGssGssQsKNSsQsGGKPGssPItKHGLSSGS
Q15648	S816	EPSD\|PSP	MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2	tsDDCPAIGtPLRDSSSSGHsQSTLFDSDVFQTNNNENPYT
Q15648	S872	EPSD\|PSP	MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2	DSPTNHFFHDGVDFNPDLLNsQsQsGFGEEYFDESsQSGDN
Q15648	S874	EPSD\|PSP	MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2	PTNHFFHDGVDFNPDLLNsQsQsGFGEEYFDESsQSGDNDD
Q15648	S887	EPSD\|PSP	MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2	PDLLNsQsQsGFGEEYFDESsQSGDNDDFKGFASQALNTLG
Q15648	S953	EPSD\|PSP	MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2	IIsVAGKALAPADLMEHHsGsQGPLLTTGDLGKEKTQKRVK
Q15797	S239	SIGNOR\|EPSD\|PSP	SMAD1 BSP1 MADH1 MADR1	PADTPPPAYLPPEDPMTQDGsQPMDTNMMAPPLPSEINRGD
Q15831	T363	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	STK11 LKB1 PJS	DLHGADEDEDLFDIEDDIIYtQDFtVPGQVPEEEASHNGQR
Q15831	T367	SIGNOR	STK11 LKB1 PJS	ADEDEDLFDIEDDIIYtQDFtVPGQVPEEEASHNGQRRGLP
Q15910	S729	SIGNOR	EZH2 KMT6	GIFAKRAIQTGEELFFDYRYsQADALKYVGIEREMEIP___
Q16204	T434	SIGNOR\|EPSD\|PSP	CCDC6 D10S170 TST1	PRRSNsPDKFKRPtPPPSPNtQTPVQPPPPPPPPPMQPTVP
Q16656	T259	PSP	NRF1	PWANVRSDVRTEEQKQRVSWtQALRTIVKNCYKQHGREDLL
Q16665	S696	SIGNOR\|EPSD\|PSP	HIF1A BHLHE78 MOP1 PASD8	VIEQTEKSHPRsPNVLsVALsQRTtVPEEELNPKILALQNA
Q4G0J3	T440	SIGNOR\|PSP	LARP7 HDCMA18P	GVPQNTGMKNEKTANREECRtQEKVNATGPQFVSGVIVKII
Q504Q3	S1003	SIGNOR\|PSP	PAN2 KIAA0710 USP52	TLNEEEAELRSDGTKSTIKPsQMSVARITCVRGQGPNEGIP
Q587J8	T145	SIGNOR\|PSP	KHDC3L C6orf221 ECAT1	DVATQKAETQRSSIEVREAGtQRSVEVREAGtQRSVEVQEV
Q587J8	T156	SIGNOR\|PSP	KHDC3L C6orf221 ECAT1	SSIEVREAGtQRSVEVREAGtQRSVEVQEVGTQGSPVEVQE
Q5UIP0	S1851	EPSD\|PSP	RIF1	IVNFREEICDMDssEAMSLEsQEsPNENFKTVGPCLGDSKN
Q5VTR2	S172	SIGNOR\|EPSD\|PSP	RNF20 BRE1A	QEPAFSFLATLASSSSEEMEsQLQERVESSRRAVSQIVTVY
Q5VTR2	S522	EPSD\|PSP	RNF20 BRE1A	REAQSDLNKTRLRsGsALLQsQsstEDPKDEPAELKPDSED
Q5VTR2	S545	EPSD\|PSP	RNF20 BRE1A	stEDPKDEPAELKPDSEDLSsQSSASKAsQEDANEIKSKRD
Q5XUX0	S278	GPS6\|SIGNOR\|EPSD\|PSP	FBXO31 FBX14 FBX31 PP2386	LEDIFHEHMQELILMKFIYTsQYDNCLTYRRIYLPPSRPDD
Q6PCD5	S46	GPS6\|EPSD\|PSP	RFWD3 RNF201	MASSQGGPALLQPVPADVVSsQGVPSILQPAPAEVISsQAT
Q6PCD5	S63	GPS6\|EPSD\|PSP	RFWD3 RNF201	VVSsQGVPSILQPAPAEVISsQATPPLLQPAPQLSVDLTEV
Q6UWZ7	S404	SIGNOR\|EPSD\|PSP	ABRAXAS1 ABRA1 CCDC98 FAM175A UNQ496/PRO1013	KMssPEtDEEIEKMKGFGEYsRsPtF_______________
Q6UWZ7	S406	SIGNOR\|EPSD\|PSP	ABRAXAS1 ABRA1 CCDC98 FAM175A UNQ496/PRO1013	ssPEtDEEIEKMKGFGEYsRsPtF_________________
Q70CQ2	S1751	EPSD\|PSP	USP34 KIAA0570 KIAA0729	CKEYFWLLCKLVDNIHIKDAsQTTLLDLDALARHLADCIRS
Q70CQ2	S718	EPSD\|PSP	USP34 KIAA0570 KIAA0729	SEDPEHDISGEMNATHIAQGsQESCITRTGDFLGETIGNEL
Q7L7X3	S990	SIGNOR\|EPSD\|PSP	TAOK1 KIAA1361 MAP3K16 MARKK	RRTAsGGRTEQGMSRstsVTsQIsNGSHMsYT_________
Q7L7X3	T643	SIGNOR\|EPSD\|PSP	TAOK1 KIAA1361 MAP3K16 MARKK	LLGRHNLEQDLVREELNKRQtQKDLEHAMLLRQHESMQELE
Q7L7X3	T785	SIGNOR\|EPSD\|PSP	TAOK1 KIAA1361 MAP3K16 MARKK	TRKLAILAEQYDHSINEMLStQALRLDEAQEAECQVLKMQL
Q7LG56	S72	SIGNOR\|EPSD\|PSP	RRM2B P53R2	IWKMYKQAQASFWTAEEVDLsKDLPHWNKLKADEKYFISHI
Q7Z6Z7	S2339	EPSD\|PSP	HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272	MDGEAETDSVVIAGQPEVLSsQEMQVENELEDLIDELLERD
Q7Z6Z7	S2636	EPSD\|PSP	HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272	IARsDDELLDDFFHDQstAtsQAGTLSSIPTALTRWTEECK
Q7Z6Z7	S3377	EPSD\|PSP	HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272	KETNCESDRERGNKACsPCssQssssGICTDFWDLLVKLDN
Q7Z6Z7	S3695	EPSD\|PSP	HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272	KLKGKMQSRFDMAENVVIVAsQKRPLGGRELQLPSMSMLTS
Q7Z6Z7	S3797	EPSD\|PSP	HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272	QMVREGQRARRQQQAATsEssQSEASVRREEsPMDVDQPsP
Q7Z6Z7	S927	EPSD\|PSP	HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272	VHTCRVGQSEIRSISVNQWGsQLGLSVLSKLSQLYCSLVWE
Q86U44	S43	SIGNOR\|PSP	METTL3 MTA70	QRRRKQDsGHLDLRNPEAALsPtFRsDsPVPtAPtsGGPKP
Q86U86	S948	EPSD\|PSP	PBRM1 BAF180 PB1	AEKsEDssGAAGLSGLHRtYsQDCsFKNSMYHVGDYVYVEP
Q8IUQ4	S19	GPS6\|SIGNOR\|EPSD\|PSP	SIAH1 HUMSIAH	__MSRQTATALPTGTSKCPPsQRVPALTGTTASNNDLASLF
Q8IW19	S116	GPS6\|EPSD\|PSP	APLF C2orf13 PALF XIP1	YIFRILSIPSEVEMQCTLRNsQVLDEDNILNEtPKsPVINL
Q8IX03	T1006	EPSD\|PSP	WWC1 KIAA0869 KIBRA	RTSLDLELDLQATRTWHSQLtQEISVLKELKEQLEQAKSHG
Q8IY92	S1138	EPSD\|PSP	SLX4 BTBD12 KIAA1784 KIAA1987	PEKSPSIDLTQSNPDHSSSRsQKSSSKLNEEDEVILLLDsD
Q8IY92	S1271	EPSD\|PSP	SLX4 BTBD12 KIAA1784 KIAA1987	TDTSWLVPATPLASRSRDCSsQTQISSLRSGLAVQAVtQHt
Q8IY92	S1631	EPSD\|PSP	SLX4 BTBD12 KIAA1784 KIAA1987	EDESQSSQPLLQAPHCQTLAsQTYKPSRAGVHAQQEATTGP
Q8IY92	S1716	EPSD\|PSP	SLX4 BTBD12 KIAA1784 KIAA1987	IPASQESVATSVDGSDSSLSsQSSSSCEFGAAFESAGEEEG
Q8IZL8	S1033	PSP	PELP1 HMX3 MNAR	GtEEERGADTAPTLAPEALPsQGEVEREGEsPAAGPPPQEL
Q8N0Z6	S203	SIGNOR	TTC5	YILGNSYLSLYFSTGQNPKIsQQALSAYAQAEKVDRKASSN
Q8N163	T454	SIGNOR	CCAR2 DBC1 KIAA1967	PTLEEWEALCQQKAAEAAPPtQEAQGEtEPTEQAPDALEQA
Q8N680	S115	EPSD\|PSP	ZBTB2 KIAA1483 ZNF437	LEQGIKFLHAYPLIQEASLAsQGAFSHPDQVFPLASSLYGI
Q8NEM0	S322	PSP	MCPH1	LQRNIAGKVVTPDQKQAAGMsQETFEEKYRLsPtLsstKGH
Q8NHY2	S387	SIGNOR\|EPSD\|PSP	COP1 RFWD2 RNF200	LEQCYFSTRMSRISDDSRTAsQLDEFQECLSKFTRYNSVRP
Q8TAQ2	S969	EPSD\|PSP	SMARCC2 BAF170	QHFQQMHQQQQQPPPALPPGsQPIPPTGAAGPPAVHGLAVA
Q8TAQ5	S68	SIGNOR\|EPSD\|PSP	ZNF420	PSRCASKDLSPEKNTYETELsQWEMSDRLENCDLEESNSRD
Q8WVD3	S124	EPSD\|PSP	RNF138 NARF HSD-4 HSD4	SCKKYQDEYGVSSIIPNFQIsQDsVGNSNRSETstsDNtEt
Q8WYQ5	S677	SIGNOR\|PSP	DGCR8 C22orf12 DGCRK6 LP4941	CGKHTVRGWCKNKRVGKQLAsQKILQLLHPHVKNWGSLLRM
Q92499	S377	PSP	DDX1	GKLNLSQVRFLVLDEADGLLsQGYSDFINRMHNQIPQVTSD
Q92499	S671	PSP	DDX1	IWYNEMQLLSEIEEHLNCTIsQVEPDIKVPVDEFDGKVTYG
Q92547	S1138	iPTMNet\|EPSD\|PSP	TOPBP1 KIAA0259	RVLEALRQSRQTVPDVNTEPsQNEQIIWDDPTAREERARLA
Q92547	S492	iPTMNet\|EPSD\|PSP	TOPBP1 KIAA0259	FSKKDFAPSEKHEQADEDLLsQYENGSSTVVEAKTSEARPF
Q92547	S554	iPTMNet\|EPSD\|PSP	TOPBP1 KIAA0259	QSSVSHCVPDVSTITEEGLFsQKSFLVLGFSNENESNIANI
Q92547	S853	iPTMNet\|EPSD\|PSP	TOPBP1 KIAA0259	FKPSFDVKDALAALEtPGRPsQQKRKPstPLsEVIVKNLQL
Q92547	T1062	iPTMNet\|EPSD\|PSP	TOPBP1 KIAA0259	NNKESAPSNGSGKNDSKGVLtQTLEMRENFQKQLQEIMSAT
Q92630	S442	GPS6\|SIGNOR\|EPSD\|PSP	DYRK2	LPGEDEGDQLACMIELLGMPsQKLLDAsKRAKNFVSSKGYP
Q92630	T106	GPS6\|SIGNOR\|EPSD\|PSP	DYRK2	GQIQVQQLFEDNSNKRTVLTtQPNGLTTVGKTGLPVVPERQ
Q92878	S635	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RAD50	LKRKEEQLsSyEDKLFDVCGsQDFESDLDRLKEEIEKSSKQ
Q92903	T68	GPS6	CDS1 CDS	GDLDSRTDSDIPEIPPSSDRtPEILKKALSGLSSRWKNWWI
Q92905	S320	PSP	COPS5 CSN5 JAB1	LAKATRDSCKTTIEAIHGLMsQVIKDKLFNQINIS______
Q92945	S274	SIGNOR\|EPSD\|PSP	KHSRP FUBP2	ETIKQLQERAGVKMILIQDGsQNtNVDKPLRIIGDPYKVQQ
Q92945	S670	SIGNOR\|EPSD\|PSP	KHSRP FUBP2	EYYKKQAQVATGGGPGAPPGsQPDYSAAWAEYYRQQAAyYG
Q969H0	S26	SIGNOR\|EPSD\|PSP	FBXW7 FBW7 FBX30 SEL10	LSVGsKRRRTGGsLRGNPSssQVDEEQMNRVVEEEQQQQLR
Q969R5	S335	EPSD\|PSP	L3MBTL2	MVESMKYPFRQGMRLEVVDKsQVSRTRMAVVDTVIGGRLRL
Q96J02	S162	SIGNOR	ITCH	LQLESEVVTNGETTCSENGVsLCLPRLECNSAISAHCNLCL
Q96KQ7	S569	EPSD\|PSP	EHMT2 BAT8 C6orf30 G9A KMT1C NG36	PRGDGVtPPAGtAAPAPPPLsQDVPGRADTSQPSARMRGHG
Q96RL1	S205	GPS6\|EPSD\|PSP	UIMC1 RAP80 RXRIP110	HTEKTEEEPVsGssGsWDQssQPVFENVNVKSFDRCTGHSA
Q96RL1	S402	GPS6	UIMC1 RAP80 RXRIP110	KSLKEKLLLEEEPttsHGQssQGIVEEtsEEGNsVPAsQSV
Q96RU2	S495	SIGNOR\|EPSD\|PSP	USP28 KIAA1515	SVHCSVSDQTSKEststEsssQDVESTFssPEDSLPKSKPL
Q96RU2	S67	SIGNOR\|EPSD\|PSP	USP28 KIAA1515	SNGDITQAVSLLTDERVKEPsQDtVATEPSEVEGSAANKEV
Q96RU2	S714	SIGNOR\|EPSD\|PSP	USP28 KIAA1515	EWEEEQSCKIPQMEsstNsssQDYSTsQEPSVASSHGVRCL
Q96RU2	S720	EPSD\|PSP	USP28 KIAA1515	SCKIPQMEsstNsssQDYSTsQEPSVASSHGVRCLSSEHAV
Q96S59	S181	EPSD\|PSP	RANBP9 RANBPM	QEtPLPRSWsPKDKFsYIGLsQNNLRVHYKGHGKTPKDAAS
Q96S59	S550	EPSD\|PSP	RANBP9 RANBPM	NKHQssNLNVPELNSINMSRsQQVNNFTSNDVDMETDHYSN
Q96S59	S603	EPSD\|PSP	RANBP9 RANBPM	GSSKHDHEMEDCDtEMEVDSsQLRRQLCGGsQAAIERMIHF
Q96SB4	S408	PSP	SRPK1	VQNLNQESSFLSSQNGDSSTsQETDSCTPITSEVSDTMVCQ
Q96SB4	T326	PSP	SRPK1	QEEsEsPVERPLKENPPNKMtQEKLEEsstIGQDQtLMERD
Q96SD1	S503	SIGNOR\|EPSD\|PSP	DCLRE1C ARTEMIS ASCID SCIDA SNM1C	DGDVPQWEVFFKRNDEITDEsLENFPSSTVAGGsQsPKLFS
Q96SD1	S516	GPS6\|SIGNOR\|EPSD\|PSP	DCLRE1C ARTEMIS ASCID SCIDA SNM1C	NDEITDEsLENFPSSTVAGGsQsPKLFSDsDGESTHISsQN
Q96SD1	S525	iPTMNet	DCLRE1C ARTEMIS ASCID SCIDA SNM1C	ENFPSSTVAGGsQsPKLFSDsDGESTHISsQNSsQSTHITE
Q96SD1	S534	GPS6	DCLRE1C ARTEMIS ASCID SCIDA SNM1C	GGsQsPKLFSDsDGESTHISsQNSsQSTHITEQGsQGWDsQ
Q96SD1	S538	GPS6	DCLRE1C ARTEMIS ASCID SCIDA SNM1C	sPKLFSDsDGESTHISsQNSsQSTHITEQGsQGWDsQSDTV
Q96SD1	S645	GPS6\|SIGNOR\|EPSD\|PSP	DCLRE1C ARTEMIS ASCID SCIDA SNM1C	SSETHIPEEKSLLNLSTNADsQsssDFEVPstPEAELPKRE
Q96SD1	S647	PSP	DCLRE1C ARTEMIS ASCID SCIDA SNM1C	ETHIPEEKSLLNLSTNADsQsssDFEVPstPEAELPKREHL
Q96SD1	S648	PSP	DCLRE1C ARTEMIS ASCID SCIDA SNM1C	THIPEEKSLLNLSTNADsQsssDFEVPstPEAELPKREHLQ
Q96SD1	S649	PSP	DCLRE1C ARTEMIS ASCID SCIDA SNM1C	HIPEEKSLLNLSTNADsQsssDFEVPstPEAELPKREHLQY
Q96SD1	T656	PSP	DCLRE1C ARTEMIS ASCID SCIDA SNM1C	LLNLSTNADsQsssDFEVPstPEAELPKREHLQYLYEKLAT
Q96T60	S114	GPS6\|SIGNOR\|EPSD\|PSP	PNKP	YLVNGLHPLTLRWEEtRtPEsQPDtPPGtPLVsQDEKRDAE
Q96T60	S126	GPS6\|SIGNOR\|EPSD\|PSP	PNKP	WEEtRtPEsQPDtPPGtPLVsQDEKRDAELPKKRMRKsNPG
Q99504	S266	EPSD\|PSP	EYA3	APAPAAQRLssGDPstsPsLsQttPsKDtDDQSRKNMTSKN
Q99638	S272	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RAD9A	KDSLLDGHFVLAtLsDtDsHsQDLGsPERHQPVPQLQAHSt
Q99708	S664	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RBBP8 CTIP	NNQDVSFENIQWSIDPGADLsQYKMDVTVIDTKDGSQSKLG
Q99708	S745	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	RBBP8 CTIP	EDMFDRtTHEEYESCLADSFsQAADEEEELSTATKKLHTHG
Q99728	T714	GPS6	BARD1	LVTAGGGQILSRKPKPDSDVtQTINTVAYHARPDSDQRFCt
Q99728	T734	GPS6	BARD1	tQTINTVAYHARPDSDQRFCtQYIIYEDLCNYHPERVRQGK
Q99801	T134	SIGNOR\|EPSD\|PSP	NKX3-1 NKX3.1 NKX3A	PRLPQTPKQPQKRSRAAFSHtQVIELERKFSHQKYLSAPER
Q99801	T166	SIGNOR\|EPSD\|PSP	NKX3-1 NKX3.1 NKX3A	QKYLSAPERAHLAKNLKLTEtQVKIWFQNRRYKTKRKQLss
Q9BQ15	T117	GPS6\|SIGNOR\|EPSD\|PSP	NABP2 OBFC2B SSB1 LP3587	EFCMVYSEVPNFSEPNPEYStQQAPNKAVQNDSNPSAsQPT
Q9BUR4	S64	SIGNOR\|EPSD\|PSP	WRAP53 TCAB1 WDR79	PPERGDPPRLsPDPVAGSAVsQELREGDPVsLstPLEtEFG
Q9BW19	S26	SIGNOR\|PSP	KIFC1 HSET KNSL2	sPLLEVKGNIELKRPLIKAPsQLPLsGsRLKRRPDQMEDGL
Q9BXS6	S124	EPSD\|PSP	NUSAP1 ANKT BM-037 PRO0310	NHsEIKISNPTEFQNHEKQEsQDLRATAKVPsPPDEHQEAE
Q9BXW9	S1257	GPS6\|ELM\|iPTMNet\|EPSD	FANCD2 FACD	VMMAELEKTVKKIEPGTAADsQQIHEEKLLYWNMAVRDFSI
Q9BXW9	S1401	GPS6\|SIGNOR	FANCD2 FACD	REAFWLGNLKNRDLQGEEIKsQNsQEstADEsEDDMSsQAS
Q9BXW9	S1404	GPS6\|SIGNOR\|EPSD	FANCD2 FACD	FWLGNLKNRDLQGEEIKsQNsQEstADEsEDDMSsQASKsK
Q9BXW9	S1407	SIGNOR	FANCD2 FACD	GNLKNRDLQGEEIKsQNsQEstADEsEDDMSsQASKsKAtE
Q9BXW9	S1418	GPS6	FANCD2 FACD	EIKsQNsQEstADEsEDDMSsQASKsKAtEDGEEDEVsAGE
Q9BXW9	S222	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD\|PSP	FANCD2 FACD	IAPENLQHDIITSLPEILGDsQHADVGKELSDLLIENTSLT
Q9BXW9	S717	EPSD\|PSP	FANCD2 FACD	INLLPLLFsQDFAKDGGPVTsQESGQKLVSPLCLAPYFRLL
Q9BXW9	T691	EPSD\|PSP	FANCD2 FACD	VPEGDFPFPVKALYGLEEyDtQDGIAINLLPLLFsQDFAKD
Q9H2K8	S324	GPS6\|EPSD	TAOK3 DPK JIK KDS MAP3K18	QyRKMKKILFQETRNGPLNEsQEDEEDsEHGTsLNREMDSL
Q9H2K8	S359	EPSD\|PSP	TAOK3 DPK JIK KDS MAP3K18	REMDSLGSNHSIPSMSVSTGsQSSSVNSMQEVMDESSSELV
Q9H2K8	S551	EPSD\|PSP	TAOK3 DPK JIK KDS MAP3K18	KKFQQQILAQQKKDLTTFLEsQKKQYKICKEKIKEEMNEDH
Q9H3D4	S477	SIGNOR	TP63 KET P63 P73H P73L TP73L	ssYGNssPPLNKMNSMNKLPsVsQLINPQQRNALtPTTIPD
Q9H3D4	S479	EPSD\|PSP	TP63 KET P63 P73H P73L TP73L	YGNssPPLNKMNSMNKLPsVsQLINPQQRNALtPTTIPDGM
Q9H3D4	S560	SIGNOR	TP63 KET P63 P73H P73L TP73L	PPPYPTDCSIVSFLARLGCSsCLDYFTTQGLTTIYQIEHYS
Q9H3D4	T491	SIGNOR	TP63 KET P63 P73H P73L TP73L	SMNKLPsVsQLINPQQRNALtPTTIPDGMGANIPMMGTHMP
Q9H7Z6	T392	PSP	KAT8 MOF MYST1 PP7073	ILRDFRGTLSIKDLSQMTSItQNDIISTLQSLNMVKYWKGQ
Q9H9Q4	S251	SIGNOR\|EPSD\|PSP	NHEJ1 XLF	KHQGAGDPHTSNSAsLQGIDsQCVNQPEQLVSsAPtLSAPE
Q9HAU4	S384	SIGNOR\|PSP	SMURF2	TVPRYKRDLVQKLKILRQELsQQQPQAGHCRIEVSREEIFE
Q9HB75	T788	SIGNOR\|PSP	PIDD1 LRDD PIDD	RGAGLSLAPLNLGDAETGFLtQSNLLSVAGRLGLDWPAVAL
Q9NQS1	S135	GPS6\|SIGNOR\|EPSD\|PSP	AVEN	VSNWDRyQDIEKEVNNESGEsQRGTDFSVLLSSAGDSFSQF
Q9NQS1	S308	GPS6\|SIGNOR\|EPSD\|PSP	AVEN	LLLNLDAPIKEGDNILPDQtsQDLKSKEDGEVVQEEEVCAK
Q9NRR5	S318	SIGNOR\|PSP	UBQLN4 C1orf6 CIP75 UBIN	REQFGNNPFSsLAGNSDssssQPLRTENREPLPNPWSPSPP
Q9NS23	S135	SIGNOR\|EPSD\|PSP	RASSF1 RDA32	PAVERDTNVDEPVEWETPDLsQAEIEQKIKEYNAQINSNLF
Q9NS91	S403	EPSD\|PSP	RAD18 RNF73	KLSSVCMGQEDNMTSVTNHFsQsKLDsPEELEPDREEDSSS
Q9NUW8	S365	EPSD\|PSP	TDP1	HDLSETNVYLIGSTPGRFQGsQKDNWGHFRLKKLLKDHASS
Q9NUW8	S563	EPSD\|PSP	TDP1	FLPSAFGLDSFKVKQKFFAGsQEPMATFPVPYDLPPELYGS
Q9NUW8	S81	SIGNOR\|EPSD\|PSP	TDP1	SPVKFSNTDSVLPPKRQKSGsQEDLGWCLSSSDDELQPEMP
Q9NVI1	S1121	EPSD\|PSP	FANCI KIAA1794	WLITKLKGQVsQEtLsEEAssQAtLPNQPVEKAIIMQLGTL
Q9NVI1	S556	EPSD\|PSP	FANCI KIAA1794	AVAGFLLLLKNFKVLGSLSSsQCsQSLSVsQVHVDVHSHYN
Q9NVI1	S559	EPSD\|PSP	FANCI KIAA1794	GFLLLLKNFKVLGSLSSsQCsQSLSVsQVHVDVHSHYNSVA
Q9NVI1	S730	SIGNOR\|EPSD\|PSP	FANCI KIAA1794	TNRMIKSELEDFELDKsADFsQSTSIGIKNNICAFLVMGVC
Q9NVI1	S972	EPSD\|PSP	FANCI KIAA1794	tQRTAFQIRQFQRSLLNLLSsQEEDFNSKEALLLVTVLTSL
Q9NY61	S189	SIGNOR\|EPSD\|PSP	AATF CHE1 DED HSPC277	SSEEEEDEESGMEEGDDAEDsQGESEEDRAGDRNsEDDGVV
Q9NZM5	S233	SIGNOR\|EPSD\|PSP	NOP53 GLT GLTSCR2 PICT1	FLEQTKKKGVKRPARLHTKPsQAPAVEVAPAGASYNPSFED
Q9NZM5	T289	SIGNOR\|EPSD\|PSP	NOP53 GLT GLTSCR2 PICT1	QKEAEKLERQLALPATEQAAtQESTFQELCEGLLEESDGEG
Q9UBU7	S502	SIGNOR\|EPSD\|PSP	DBF4 ASK DBF4A ZDBF1	YKCNIQASVHVSDFSTDNSGsQPKQKsDtVLFPAKDLKEKD
Q9UBU7	S539	SIGNOR\|EPSD\|PSP	DBF4 ASK DBF4A ZDBF1	KEKDLHSIFTHDSGLITINSsQEHLTVQAKAPFHtPPEEPN
Q9UBU7	T449	SIGNOR\|EPSD\|PSP	DBF4 ASK DBF4A ZDBF1	KMSNKCSMLSTAEDDIRQNFtQLPLHKNKQECILDISEHTL
Q9UER7	S564	SIGNOR\|EPSD\|PSP	DAXX BING2 DAP6	DAESNGEQPEELTLEEESPVsQLFELEIEALPLDTPSSVET
Q9UGP5	T204	SIGNOR\|EPSD\|PSP	POLL	EAPNTQAQPISDDEASDGEEtQVSAADLEALISGHYPTSLE
Q9UMS4	S149	PSP	PRPF19 NMP200 PRP19 SNEV	EALATLKPQAGLIVPQAVPssQPSVVGAGEPMDLGELVGMT
Q9UPV0	S186	GPS6\|EPSD	CEP164 KIAA1052 NPHP15	SVSLGSSVESGRQLGELMLPsQGLKTSAYTKGLLGSIyEDK
Q9UQE7	S1083	SIGNOR\|EPSD\|PSP	SMC3 BAM BMH CSPG6 SMC3L1	EGsQsQDEGEGsGEsERGsGsQssVPsVDQFTGVGIRVSFT
Q9UQR1	S202	GPS6\|SIGNOR\|EPSD\|PSP	ZNF148 ZBP89	TNYHLQRHVFIHtGEKPFQCsQCDMRFIQKYLLQRHEKIHT
Q9Y297	S158	SIGNOR\|PSP	BTRC BTRCP FBW1A FBXW1A	VKYFEQWSESDQVEFVEHLIsQMCHYQHGHINSYLKPMLQR
Q9Y2K7	T632	EPSD\|PSP	KDM2A CXXC8 FBL11 FBL7 FBXL11 JHDM1A KIAA1004	PRLPHSVTCSLCGEVDQNEEtQDFEKKLMECCICNEIVHPG
Q9Y4E8	S678	EPSD\|PSP	USP15 KIAA0529	TDEPDDESSQDQELPSENENsQSEDSVGGDNDSENGLCTED
Q9Y4P3	T433	GPS6\|EPSD	TBL2 WBSCR13 UNQ563/PRO1125	QGHLKRASNESTRQRLQQQLtQAQETLKSLGALKK______
Q9Y6D9	S214	EPSD\|PSP	MAD1L1 MAD1 TXBP181	LDLQHKKCQEANQKIQELQAsQEARADHEQQIKDLEQKLSL
Q9Y6K9	S85	GPS6\|SIGNOR\|ELM\|iPTMNet\|EPSD	IKBKG FIP3 NEMO	IRQsNQILRERCEELLHFQAsQREEKEFLMCKFQEARKLVE

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

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name	reactome_id	p	-log10p	ref_path	ref_path_lowest
DNA Double-Strand Break Repair	R-HSA-5693532	1.110223e-16	15.955	1	0
Cell Cycle	R-HSA-1640170	1.110223e-16	15.955	1	0
Cell Cycle Checkpoints	R-HSA-69620	5.462297e-14	13.263	1	0
Homology Directed Repair	R-HSA-5693538	7.460699e-14	13.127	1	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	1.401101e-13	12.854	1	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	5.497824e-13	12.260	1	1
G2/M DNA damage checkpoint	R-HSA-69473	1.126765e-12	11.948	1	1
DNA Repair	R-HSA-73894	5.034084e-12	11.298	1	0
Cell Cycle, Mitotic	R-HSA-69278	9.552026e-12	11.020	0	0
G2/M Checkpoints	R-HSA-69481	3.627743e-11	10.440	1	0
Processing of DNA double-strand break ends	R-HSA-5693607	4.902712e-11	10.310	1	1
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	6.248069e-11	10.204	1	1
M Phase	R-HSA-68886	5.361429e-10	9.271	0	0
DNA Double Strand Break Response	R-HSA-5693606	1.073298e-09	8.969	1	0
Chromatin organization	R-HSA-4839726	1.045125e-08	7.981	0	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	5.339375e-08	7.273	1	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	5.339375e-08	7.273	1	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	6.340210e-08	7.198	1	1
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	8.962920e-08	7.048	1	1
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	1.001908e-07	6.999	1	1
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	1.126532e-07	6.948	1	1
Chromatin modifying enzymes	R-HSA-3247509	1.144964e-07	6.941	0	0
Mitotic Prometaphase	R-HSA-68877	2.534621e-07	6.596	0	0
Impaired BRCA2 binding to RAD51	R-HSA-9709570	3.532282e-07	6.452	1	1
HDR through Homologous Recombination (HRR)	R-HSA-5685942	4.501906e-07	6.347	1	1
Meiosis	R-HSA-1500620	4.995484e-07	6.301	1	0
Impaired BRCA2 binding to PALB2	R-HSA-9709603	1.081497e-06	5.966	1	1
Apoptotic cleavage of cellular proteins	R-HSA-111465	1.171262e-06	5.931	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	1.242169e-06	5.906	0	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	1.292290e-06	5.889	1	1
Diseases of DNA repair	R-HSA-9675135	1.398250e-06	5.854	1	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.769763e-06	5.752	1	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.769763e-06	5.752	1	1
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.769763e-06	5.752	1	1
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.769763e-06	5.752	1	1
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	2.102415e-06	5.677	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	2.818616e-06	5.550	0	0
Meiotic synapsis	R-HSA-1221632	3.174111e-06	5.498	0	0
Deubiquitination	R-HSA-5688426	3.296672e-06	5.482	0	0
Estrogen-dependent gene expression	R-HSA-9018519	4.466411e-06	5.350	0	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	5.366607e-06	5.270	1	1
Mitotic Prophase	R-HSA-68875	5.579025e-06	5.253	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	7.893977e-06	5.103	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	8.029929e-06	5.095	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	9.091434e-06	5.041	0	0
Transcriptional Regulation by TP53	R-HSA-3700989	9.197697e-06	5.036	1	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	9.829222e-06	5.007	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	9.797418e-06	5.009	0	0
Apoptotic execution phase	R-HSA-75153	1.501223e-05	4.824	0	0
Meiotic recombination	R-HSA-912446	1.788448e-05	4.748	1	1
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	1.832796e-05	4.737	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	2.238092e-05	4.650	0	0
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	2.360503e-05	4.627	1	1
Mitotic Anaphase	R-HSA-68882	2.386910e-05	4.622	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	2.671374e-05	4.573	0	0
Cellular Senescence	R-HSA-2559583	3.073743e-05	4.512	1	0
Resolution of D-Loop Structures	R-HSA-5693537	3.219536e-05	4.492	1	0
Signaling by Hippo	R-HSA-2028269	4.598361e-05	4.337	0	0
HDACs deacetylate histones	R-HSA-3214815	4.660150e-05	4.332	0	0
Cell-Cell communication	R-HSA-1500931	4.755453e-05	4.323	0	0
Separation of Sister Chromatids	R-HSA-2467813	5.761261e-05	4.239	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	7.022555e-05	4.154	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	6.945317e-05	4.158	0	0
Signaling by ALK in cancer	R-HSA-9700206	6.945317e-05	4.158	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	7.437171e-05	4.129	0	0
Amplification of signal from the kinetochores	R-HSA-141424	7.437171e-05	4.129	0	0
Activation of ATR in response to replication stress	R-HSA-176187	8.109770e-05	4.091	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	8.537950e-05	4.069	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	9.999815e-05	4.000	0	0
ESR-mediated signaling	R-HSA-8939211	1.186826e-04	3.926	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	1.252326e-04	3.902	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	1.490549e-04	3.827	0	0
Reproduction	R-HSA-1474165	1.565511e-04	3.805	1	0
Packaging Of Telomere Ends	R-HSA-171306	1.569889e-04	3.804	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	1.664725e-04	3.779	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	2.005102e-04	3.698	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	2.171665e-04	3.663	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	2.498580e-04	3.602	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	2.503716e-04	3.601	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	2.513718e-04	3.600	0	0
Regulation of TP53 Activity	R-HSA-5633007	2.606162e-04	3.584	1	0
DNA methylation	R-HSA-5334118	2.824376e-04	3.549	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	2.956831e-04	3.529	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	2.956831e-04	3.529	0	0
Ub-specific processing proteases	R-HSA-5689880	3.454855e-04	3.462	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	3.751498e-04	3.426	0	0
Membrane Trafficking	R-HSA-199991	3.799674e-04	3.420	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	4.183245e-04	3.378	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	4.259690e-04	3.371	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	4.391655e-04	3.357	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	4.892546e-04	3.310	0	0
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	4.656163e-04	3.332	1	1
RNA Polymerase I Promoter Opening	R-HSA-73728	5.269469e-04	3.278	0	0
RNA Polymerase I Transcription	R-HSA-73864	5.776183e-04	3.238	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.191587e-04	3.208	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	6.278609e-04	3.202	0	0
Regulation of endogenous retroelements	R-HSA-9842860	6.238725e-04	3.205	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	5.909812e-04	3.228	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	7.100625e-04	3.149	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	7.301242e-04	3.137	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	7.701003e-04	3.113	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	7.759101e-04	3.110	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	8.374922e-04	3.077	0	0
Kinesins	R-HSA-983189	8.577898e-04	3.067	0	0
Death Receptor Signaling	R-HSA-73887	8.749135e-04	3.058	0	0
Cleavage of the damaged purine	R-HSA-110331	8.882166e-04	3.051	0	0
Gene expression (Transcription)	R-HSA-74160	9.037963e-04	3.044	1	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.059878e-03	2.975	0	0
Depurination	R-HSA-73927	1.105659e-03	2.956	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	1.192570e-03	2.924	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	1.145465e-03	2.941	0	0
Interleukin-37 signaling	R-HSA-9008059	1.149042e-03	2.940	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.205195e-03	2.919	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	1.219967e-03	2.914	0	0
G2/M Transition	R-HSA-69275	1.244744e-03	2.905	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	1.276162e-03	2.894	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.334861e-03	2.875	0	0
Signaling by TGF-beta Receptor Complex	R-HSA-170834	1.358039e-03	2.867	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.446939e-03	2.840	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	1.419897e-03	2.848	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	1.419897e-03	2.848	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	1.491804e-03	2.826	0	0
Mitotic G2-G2/M phases	R-HSA-453274	1.492104e-03	2.826	0	0
PKR-mediated signaling	R-HSA-9833482	1.709878e-03	2.767	0	0
HATs acetylate histones	R-HSA-3214847	1.749187e-03	2.757	0	0
Signal Transduction	R-HSA-162582	1.780595e-03	2.749	0	0
Centrosome maturation	R-HSA-380287	1.795122e-03	2.746	0	0
Nephrin family interactions	R-HSA-373753	1.987077e-03	2.702	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.987077e-03	2.702	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	2.009685e-03	2.697	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.875490e-03	2.727	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	1.948211e-03	2.710	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	1.948211e-03	2.710	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	2.052094e-03	2.688	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	2.079512e-03	2.682	0	0
Nucleosome assembly	R-HSA-774815	2.079512e-03	2.682	0	0
Cell junction organization	R-HSA-446728	2.211287e-03	2.655	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	2.250362e-03	2.648	0	0
AURKA Activation by TPX2	R-HSA-8854518	2.269309e-03	2.644	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	2.477582e-03	2.606	0	0
mRNA Splicing	R-HSA-72172	2.273907e-03	2.643	0	0
Epigenetic regulation of gene expression	R-HSA-212165	2.321521e-03	2.634	0	0
NRAGE signals death through JNK	R-HSA-193648	2.423501e-03	2.616	0	0
Assembly of the ORC complex at the origin of replication	R-HSA-68616	2.291038e-03	2.640	0	0
Axon guidance	R-HSA-422475	2.486373e-03	2.604	0	0
Adherens junctions interactions	R-HSA-418990	2.614354e-03	2.583	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	2.854837e-03	2.544	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	2.921968e-03	2.534	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	2.921968e-03	2.534	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	2.938365e-03	2.532	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	2.962318e-03	2.528	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	2.979750e-03	2.526	0	0
Depyrimidination	R-HSA-73928	2.979750e-03	2.526	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	3.046541e-03	2.516	0	0
DNA Replication Pre-Initiation	R-HSA-69002	3.278794e-03	2.484	0	0
Metabolism of RNA	R-HSA-8953854	3.225000e-03	2.491	0	0
RNA Polymerase II Transcription	R-HSA-73857	3.472265e-03	2.459	1	0
Apoptosis	R-HSA-109581	3.337821e-03	2.477	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	3.758121e-03	2.425	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	3.829995e-03	2.417	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.985414e-03	2.400	0	0
DCC mediated attractive signaling	R-HSA-418885	3.993728e-03	2.399	0	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	3.998178e-03	2.398	0	0
Nervous system development	R-HSA-9675108	4.078882e-03	2.389	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	4.081218e-03	2.389	0	0
Cellular response to heat stress	R-HSA-3371556	4.231868e-03	2.373	1	0
Netrin-1 signaling	R-HSA-373752	4.243122e-03	2.372	0	0
Aggrephagy	R-HSA-9646399	4.275635e-03	2.369	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	4.380965e-03	2.358	0	0
COPI-mediated anterograde transport	R-HSA-6807878	4.659382e-03	2.332	0	0
Post NMDA receptor activation events	R-HSA-438064	4.839491e-03	2.315	0	0
Inactivation of CDC42 and RAC1	R-HSA-428543	5.411178e-03	2.267	0	0
Unwinding of DNA	R-HSA-176974	5.411178e-03	2.267	0	0
PRC2 methylates histones and DNA	R-HSA-212300	5.118115e-03	2.291	0	0
Chromatin modifications during the maternal to zygotic transition (MZT)	R-HSA-9821002	5.108642e-03	2.292	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	6.144784e-03	2.211	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	6.567182e-03	2.183	0	0
Base Excision Repair	R-HSA-73884	6.857495e-03	2.164	0	0
Recycling pathway of L1	R-HSA-437239	6.925541e-03	2.160	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	7.049090e-03	2.152	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	7.150542e-03	2.146	0	0
Striated Muscle Contraction	R-HSA-390522	7.380702e-03	2.132	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	7.451968e-03	2.128	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	7.707213e-03	2.113	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.853279e-03	2.105	0	0
Cilium Assembly	R-HSA-5617833	7.884954e-03	2.103	0	0
L1CAM interactions	R-HSA-373760	8.244347e-03	2.084	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	8.300891e-03	2.081	0	0
p75NTR negatively regulates cell cycle via SC1	R-HSA-193670	8.394886e-03	2.076	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	8.394886e-03	2.076	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	8.846973e-03	2.053	0	0
Activation of the pre-replicative complex	R-HSA-68962	8.846973e-03	2.053	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	8.865553e-03	2.052	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	8.866491e-03	2.052	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	9.833651e-03	2.007	0	0
Diseases of programmed cell death	R-HSA-9645723	1.037538e-02	1.984	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.057214e-02	1.976	0	0
Assembly of the pre-replicative complex	R-HSA-68867	1.057412e-02	1.976	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.074909e-02	1.969	0	0
Cell-cell junction organization	R-HSA-421270	1.087007e-02	1.964	0	0
G alpha (12/13) signalling events	R-HSA-416482	1.098974e-02	1.959	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	1.165715e-02	1.933	0	0
Ephrin signaling	R-HSA-3928664	1.180008e-02	1.928	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	1.191676e-02	1.924	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.191676e-02	1.924	0	0
Notch-HLH transcription pathway	R-HSA-350054	1.257515e-02	1.900	0	0
DNA strand elongation	R-HSA-69190	1.276409e-02	1.894	0	0
p75NTR signals via NF-kB	R-HSA-193639	1.349117e-02	1.870	0	0
Generic Transcription Pathway	R-HSA-212436	1.381089e-02	1.860	1	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	1.396683e-02	1.855	0	0
Semaphorin interactions	R-HSA-373755	1.398170e-02	1.854	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	1.604700e-02	1.795	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	1.604700e-02	1.795	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	1.604700e-02	1.795	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	1.604700e-02	1.795	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	1.604700e-02	1.795	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	1.604700e-02	1.795	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	1.604700e-02	1.795	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	1.604700e-02	1.795	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	1.604700e-02	1.795	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	1.604700e-02	1.795	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	1.604700e-02	1.795	0	0
Downregulation of ERBB4 signaling	R-HSA-1253288	1.559423e-02	1.807	0	0
HIV elongation arrest and recovery	R-HSA-167287	1.546288e-02	1.811	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	1.546288e-02	1.811	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	1.425449e-02	1.846	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	1.553110e-02	1.809	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	1.515821e-02	1.819	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	1.459666e-02	1.836	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	1.579052e-02	1.802	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	1.515821e-02	1.819	0	0
Programmed Cell Death	R-HSA-5357801	1.541277e-02	1.812	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	1.626028e-02	1.789	0	0
NGF-stimulated transcription	R-HSA-9031628	1.745675e-02	1.758	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.843247e-02	1.734	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	1.845999e-02	1.734	0	0
Signaling by SCF-KIT	R-HSA-1433557	1.866295e-02	1.729	0	0
Defective pyroptosis	R-HSA-9710421	1.866295e-02	1.729	0	0
DNA Replication	R-HSA-69306	1.932767e-02	1.714	0	0
p75NTR recruits signalling complexes	R-HSA-209543	1.979468e-02	1.703	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	1.979468e-02	1.703	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	2.091483e-02	1.680	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	2.169220e-02	1.664	0	0
ALK mutants bind TKIs	R-HSA-9700645	2.171289e-02	1.663	0	0
GP1b-IX-V activation signalling	R-HSA-430116	2.171289e-02	1.663	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	2.186326e-02	1.660	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	2.186326e-02	1.660	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	2.186939e-02	1.660	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	2.186939e-02	1.660	0	0
Sema4D in semaphorin signaling	R-HSA-400685	2.248488e-02	1.648	0	0
HDMs demethylate histones	R-HSA-3214842	2.248488e-02	1.648	0	0
Interleukin-7 signaling	R-HSA-1266695	2.248488e-02	1.648	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	2.291433e-02	1.640	0	0
Signaling by EGFR	R-HSA-177929	2.358933e-02	1.627	0	0
Interleukin-6 signaling	R-HSA-1059683	2.560378e-02	1.592	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	2.635739e-02	1.579	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	2.524392e-02	1.598	0	0
Gene Silencing by RNA	R-HSA-211000	2.676068e-02	1.573	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	2.717820e-02	1.566	0	0
Signaling by PDGFR in disease	R-HSA-9671555	2.737961e-02	1.563	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.737961e-02	1.563	0	0
HCMV Early Events	R-HSA-9609690	2.775933e-02	1.557	0	0
Protein ubiquitination	R-HSA-8852135	2.775959e-02	1.557	0	0
RUNX2 regulates bone development	R-HSA-8941326	2.819431e-02	1.550	0	0
RET signaling	R-HSA-8853659	2.819431e-02	1.550	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	2.860560e-02	1.544	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	2.860560e-02	1.544	0	0
Neurexins and neuroligins	R-HSA-6794361	2.891326e-02	1.539	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	2.920954e-02	1.534	0	0
Telomere Maintenance	R-HSA-157579	2.989303e-02	1.524	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	3.008765e-02	1.522	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	3.061357e-02	1.514	0	0
Signaling by LTK in cancer	R-HSA-9842640	3.144302e-02	1.502	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	3.160798e-02	1.500	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	3.160798e-02	1.500	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	3.330057e-02	1.478	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	3.330057e-02	1.478	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	3.330057e-02	1.478	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	3.330057e-02	1.478	0	0
Selective autophagy	R-HSA-9663891	3.332858e-02	1.477	1	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	3.422493e-02	1.466	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	3.477799e-02	1.459	0	0
Chromosome Maintenance	R-HSA-73886	3.518076e-02	1.454	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	4.038025e-02	1.394	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	4.038025e-02	1.394	0	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	4.038025e-02	1.394	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	3.896052e-02	1.409	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	4.006551e-02	1.397	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	4.222126e-02	1.374	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	4.222126e-02	1.374	1	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	3.958212e-02	1.403	0	0
Signaling by ERBB2	R-HSA-1227986	3.689205e-02	1.433	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	3.550243e-02	1.450	0	0
Signaling by NOTCH	R-HSA-157118	3.751638e-02	1.426	0	0
STING mediated induction of host immune responses	R-HSA-1834941	4.027799e-02	1.395	0	0
Signaling by NOTCH3	R-HSA-9012852	4.056675e-02	1.392	0	0
PIP3 activates AKT signaling	R-HSA-1257604	3.975420e-02	1.401	0	0
Intracellular signaling by second messengers	R-HSA-9006925	3.870096e-02	1.412	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	3.875173e-02	1.412	0	0
Cellular responses to stimuli	R-HSA-8953897	3.701681e-02	1.432	1	0
Signaling by ALK	R-HSA-201556	4.222126e-02	1.374	0	0
Cell-extracellular matrix interactions	R-HSA-446353	4.038025e-02	1.394	0	0
ChREBP activates metabolic gene expression	R-HSA-163765	3.816226e-02	1.418	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	4.339108e-02	1.363	0	0
Signaling by MET	R-HSA-6806834	4.440037e-02	1.353	0	0
NADE modulates death signalling	R-HSA-205025	4.485040e-02	1.348	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	4.486650e-02	1.348	1	1
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	4.510240e-02	1.346	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	4.517058e-02	1.345	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	4.581994e-02	1.339	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	4.581994e-02	1.339	0	0
RAF activation	R-HSA-5673000	4.587955e-02	1.338	0	0
Nuclear import of Rev protein	R-HSA-180746	4.587955e-02	1.338	0	0
Signaling by TGFB family members	R-HSA-9006936	4.693551e-02	1.328	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	4.712116e-02	1.327	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	4.780903e-02	1.320	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	4.780903e-02	1.320	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	4.851040e-02	1.314	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	4.862163e-02	1.313	1	1
NF-kB is activated and signals survival	R-HSA-209560	4.862163e-02	1.313	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	4.903376e-02	1.310	0	0
ISG15 antiviral mechanism	R-HSA-1169408	4.910224e-02	1.309	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	4.965868e-02	1.304	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	4.965868e-02	1.304	0	0
Signaling by PTK6	R-HSA-8848021	4.992262e-02	1.302	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	4.992262e-02	1.302	0	0
Signaling by NTRKs	R-HSA-166520	5.013136e-02	1.300	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	5.223754e-02	1.282	0	0
Oncogene Induced Senescence	R-HSA-2559585	5.223754e-02	1.282	0	0
Long-term potentiation	R-HSA-9620244	5.342518e-02	1.272	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	5.387858e-02	1.269	0	0
Vesicle-mediated transport	R-HSA-5653656	5.460741e-02	1.263	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	6.488109e-02	1.188	0	0
Type I hemidesmosome assembly	R-HSA-446107	5.755166e-02	1.240	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	5.755166e-02	1.240	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	5.755166e-02	1.240	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	6.061077e-02	1.217	0	0
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.965567e-02	1.224	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	6.663197e-02	1.176	0	0
EGFR downregulation	R-HSA-182971	5.693018e-02	1.245	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	5.693018e-02	1.245	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	5.693018e-02	1.245	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	7.093855e-02	1.149	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	6.664080e-02	1.176	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	6.021116e-02	1.220	0	0
Nucleotide Excision Repair	R-HSA-5696398	6.028692e-02	1.220	0	0
Regulation of TP53 Degradation	R-HSA-6804757	5.915408e-02	1.228	1	1
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	6.211475e-02	1.207	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	7.093855e-02	1.149	1	1
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	6.474330e-02	1.189	0	0
Oncogenic MAPK signaling	R-HSA-6802957	6.720881e-02	1.173	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	6.211475e-02	1.207	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	6.751015e-02	1.171	0	0
Myogenesis	R-HSA-525793	6.179409e-02	1.209	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	6.061077e-02	1.217	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	5.682771e-02	1.245	0	0
Breakdown of the nuclear lamina	R-HSA-352238	5.915214e-02	1.228	0	0
Signaling by LTK	R-HSA-9842663	6.061077e-02	1.217	0	0
Macroautophagy	R-HSA-1632852	6.824408e-02	1.166	1	0
Cellular responses to stress	R-HSA-2262752	6.670176e-02	1.176	1	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	5.939015e-02	1.226	0	0
Interferon Signaling	R-HSA-913531	6.843724e-02	1.165	0	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	6.485559e-02	1.188	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	5.755166e-02	1.240	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	7.093855e-02	1.149	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	6.824445e-02	1.166	0	0
Sensory processing of sound	R-HSA-9659379	6.885283e-02	1.162	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	7.103443e-02	1.149	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	7.103443e-02	1.149	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	7.103443e-02	1.149	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.103443e-02	1.149	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	7.344467e-02	1.134	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	7.344467e-02	1.134	0	0
S Phase	R-HSA-69242	7.383511e-02	1.132	0	0
HuR (ELAVL1) binds and stabilizes mRNA	R-HSA-450520	7.388291e-02	1.131	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	7.388291e-02	1.131	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	7.388291e-02	1.131	0	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	7.412631e-02	1.130	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	7.470618e-02	1.127	0	0
Signaling by ERBB4	R-HSA-1236394	7.640478e-02	1.117	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	7.640478e-02	1.117	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	7.727713e-02	1.112	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	7.727713e-02	1.112	0	0
mTORC1-mediated signalling	R-HSA-166208	7.727713e-02	1.112	0	0
Signaling by KIT in disease	R-HSA-9669938	7.727713e-02	1.112	0	0
Heme signaling	R-HSA-9707616	7.984184e-02	1.098	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	8.086437e-02	1.092	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	8.086437e-02	1.092	0	0
EPH-Ephrin signaling	R-HSA-2682334	8.157828e-02	1.088	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	8.270282e-02	1.082	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	8.270282e-02	1.082	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	8.272184e-02	1.082	0	0
EPHB-mediated forward signaling	R-HSA-3928662	8.318677e-02	1.080	0	0
RMTs methylate histone arginines	R-HSA-3214858	8.318677e-02	1.080	0	0
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	8.335550e-02	1.079	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	8.335550e-02	1.079	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	8.357365e-02	1.078	1	1
Chaperone Mediated Autophagy	R-HSA-9613829	8.357365e-02	1.078	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	8.471407e-02	1.072	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	8.676651e-02	1.062	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	8.829199e-02	1.054	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	8.829199e-02	1.054	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	8.829199e-02	1.054	0	0
Interleukin receptor SHC signaling	R-HSA-912526	8.885670e-02	1.051	0	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.885670e-02	1.051	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.914016e-02	1.050	0	0
Regulation of KIT signaling	R-HSA-1433559	8.914016e-02	1.050	0	0
Signal regulatory protein family interactions	R-HSA-391160	8.914016e-02	1.050	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	9.157125e-02	1.038	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	9.157125e-02	1.038	0	0
MET activates RAP1 and RAC1	R-HSA-8875555	9.229421e-02	1.035	0	0
PI3K/AKT activation	R-HSA-198203	9.229421e-02	1.035	0	0
Interleukin-27 signaling	R-HSA-9020956	9.229421e-02	1.035	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	9.229421e-02	1.035	0	0
Drug resistance of PDGFR mutants	R-HSA-9674415	1.222140e-01	0.913	0	0
PDGFR mutants bind TKIs	R-HSA-9674428	1.222140e-01	0.913	0	0
Defective translocation of RB1 mutants to the nucleus	R-HSA-9661070	1.222140e-01	0.913	0	0
Imatinib-resistant PDGFR mutants	R-HSA-9674396	1.222140e-01	0.913	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	1.222140e-01	0.913	0	0
Regorafenib-resistant PDGFR mutants	R-HSA-9674403	1.222140e-01	0.913	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	1.222140e-01	0.913	0	0
Sunitinib-resistant PDGFR mutants	R-HSA-9674401	1.222140e-01	0.913	0	0
Sorafenib-resistant PDGFR mutants	R-HSA-9674404	1.222140e-01	0.913	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	1.222140e-01	0.913	0	0
Regulation of TP53 Expression	R-HSA-6804754	9.674145e-02	1.014	0	0
Signaling by PDGFRA extracellular domain mutants	R-HSA-9673770	1.056018e-01	0.976	0	0
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	R-HSA-9673767	1.056018e-01	0.976	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	1.056018e-01	0.976	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	1.056018e-01	0.976	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	1.056018e-01	0.976	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	1.056018e-01	0.976	0	0
Regulation of signaling by CBL	R-HSA-912631	9.725578e-02	1.012	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	1.234408e-01	0.909	1	1
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	1.013599e-01	0.994	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.030529e-01	0.987	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	1.152970e-01	0.938	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	9.259074e-02	1.033	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	1.144800e-01	0.941	0	0
Signaling by RAF1 mutants	R-HSA-9656223	1.128103e-01	0.948	0	0
Metabolism of non-coding RNA	R-HSA-194441	1.052418e-01	0.978	0	0
snRNP Assembly	R-HSA-191859	1.052418e-01	0.978	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	1.036510e-01	0.984	0	0
RNA Polymerase III Transcription	R-HSA-74158	1.144800e-01	0.941	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	1.114118e-01	0.953	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	1.114118e-01	0.953	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	1.114118e-01	0.953	0	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	1.032260e-01	0.986	0	0
Prolonged ERK activation events	R-HSA-169893	1.234408e-01	0.909	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	1.120503e-01	0.951	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	1.071125e-01	0.970	0	0
DAP12 signaling	R-HSA-2424491	1.030529e-01	0.987	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	1.052418e-01	0.978	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	9.263107e-02	1.033	0	0
Rap1 signalling	R-HSA-392517	9.725578e-02	1.012	0	0
PKMTs methylate histone lysines	R-HSA-3214841	1.024106e-01	0.990	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	1.154244e-01	0.938	0	0
Signaling by VEGF	R-HSA-194138	1.114118e-01	0.953	0	0
Autophagy	R-HSA-9612973	1.122363e-01	0.950	1	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	1.146907e-01	0.940	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	1.234288e-01	0.909	0	0
Co-stimulation by CD28	R-HSA-389356	1.207596e-01	0.918	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	9.259074e-02	1.033	0	0
GPVI-mediated activation cascade	R-HSA-114604	1.144800e-01	0.941	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.035486e-01	0.985	0	0
Nef and signal transduction	R-HSA-164944	1.146907e-01	0.940	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	1.013599e-01	0.994	0	0
Neurodegenerative Diseases	R-HSA-8863678	1.013599e-01	0.994	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	1.234408e-01	0.909	0	0
Signaling by FGFR in disease	R-HSA-1226099	1.237123e-01	0.908	0	0
MTOR signalling	R-HSA-165159	1.237821e-01	0.907	0	0
Ovarian tumor domain proteases	R-HSA-5689896	1.263810e-01	0.898	0	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.263810e-01	0.898	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	1.279149e-01	0.893	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	1.279149e-01	0.893	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.279149e-01	0.893	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.279149e-01	0.893	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	1.279149e-01	0.893	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	1.290527e-01	0.889	0	0
Metalloprotease DUBs	R-HSA-5689901	1.290527e-01	0.889	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	1.314303e-01	0.881	0	0
DNA Damage Bypass	R-HSA-73893	1.314303e-01	0.881	0	0
Gap junction trafficking and regulation	R-HSA-157858	1.314303e-01	0.881	0	0
tRNA processing in the nucleus	R-HSA-6784531	1.329895e-01	0.876	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.348031e-01	0.870	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	1.348031e-01	0.870	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.348031e-01	0.870	0	0
MHC class II antigen presentation	R-HSA-2132295	1.361143e-01	0.866	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	1.384123e-01	0.859	0	0
TRKA activation by NGF	R-HSA-187042	1.391975e-01	0.856	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.391975e-01	0.856	0	0
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	1.391975e-01	0.856	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	1.391975e-01	0.856	0	0
Signalling to STAT3	R-HSA-198745	1.391975e-01	0.856	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	1.391975e-01	0.856	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	1.391975e-01	0.856	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	1.419958e-01	0.848	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	1.419958e-01	0.848	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	1.425700e-01	0.846	0	0
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	1.425700e-01	0.846	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	1.425700e-01	0.846	0	0
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	R-HSA-8866910	1.425700e-01	0.846	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	1.436406e-01	0.843	0	0
Netrin mediated repulsion signals	R-HSA-418886	1.436406e-01	0.843	0	0
Regulation of PTEN localization	R-HSA-8948747	1.436406e-01	0.843	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	1.436406e-01	0.843	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	1.436406e-01	0.843	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	1.441806e-01	0.841	0	0
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	1.441806e-01	0.841	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	1.447964e-01	0.839	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	1.462808e-01	0.835	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	2.294979e-01	0.639	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	2.294979e-01	0.639	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	2.294979e-01	0.639	0	0
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	2.294979e-01	0.639	0	0
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	2.294979e-01	0.639	0	0
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	2.294979e-01	0.639	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	2.294979e-01	0.639	0	0
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	2.294979e-01	0.639	0	0
TICAM1 deficiency - HSE	R-HSA-5602566	2.294979e-01	0.639	0	0
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	R-HSA-5619043	2.294979e-01	0.639	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	2.294979e-01	0.639	0	0
Regulation of gap junction activity	R-HSA-191650	1.847704e-01	0.733	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.847704e-01	0.733	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	1.847704e-01	0.733	0	0
PLCG1 events in ERBB2 signaling	R-HSA-1251932	1.847704e-01	0.733	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	1.847704e-01	0.733	0	0
ARL13B-mediated ciliary trafficking of INPP5E	R-HSA-5624958	3.236750e-01	0.490	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	3.236750e-01	0.490	0	0
NFG and proNGF binds to p75NTR	R-HSA-205017	3.236750e-01	0.490	0	0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	3.236750e-01	0.490	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5660686	3.236750e-01	0.490	0	0
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	R-HSA-5619101	3.236750e-01	0.490	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	3.236750e-01	0.490	0	0
TRAF3 deficiency - HSE	R-HSA-5602571	3.236750e-01	0.490	0	0
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	R-HSA-5619050	3.236750e-01	0.490	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	3.236750e-01	0.490	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.236750e-01	0.490	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	2.320651e-01	0.634	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	2.320651e-01	0.634	0	0
NOSIP mediated eNOS trafficking	R-HSA-203754	2.320651e-01	0.634	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	2.320651e-01	0.634	0	0
MET receptor recycling	R-HSA-8875656	1.746889e-01	0.758	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	1.585536e-01	0.800	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	1.585536e-01	0.800	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	1.585536e-01	0.800	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	1.585536e-01	0.800	0	0
IRAK1 recruits IKK complex	R-HSA-937039	1.585536e-01	0.800	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	1.585536e-01	0.800	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	1.585536e-01	0.800	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	1.585536e-01	0.800	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	1.585536e-01	0.800	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	2.073861e-01	0.683	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	2.073861e-01	0.683	0	0
MAPK1 (ERK2) activation	R-HSA-112411	2.073861e-01	0.683	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	2.799808e-01	0.553	0	0
CDH11 homotypic and heterotypic interactions	R-HSA-9833576	2.799808e-01	0.553	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	2.799808e-01	0.553	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	2.799808e-01	0.553	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	2.799808e-01	0.553	0	0
Activation, myristolyation of BID and translocation to mitochondria	R-HSA-75108	4.063458e-01	0.391	0	0
Regulation of cortical dendrite branching	R-HSA-8985801	4.063458e-01	0.391	0	0
TGFBR1 LBD Mutants in Cancer	R-HSA-3656535	4.063458e-01	0.391	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	4.063458e-01	0.391	0	0
Essential pentosuria	R-HSA-5662853	4.063458e-01	0.391	0	0
Folding of actin by CCT/TriC	R-HSA-390450	2.413007e-01	0.617	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	2.100495e-01	0.678	0	0
Removal of the Flap Intermediate	R-HSA-69166	2.100495e-01	0.678	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	3.276596e-01	0.485	0	0
CREB phosphorylation	R-HSA-199920	3.276596e-01	0.485	0	0
Chylomicron clearance	R-HSA-8964026	3.276596e-01	0.485	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	3.276596e-01	0.485	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	3.276596e-01	0.485	0	0
GAB1 signalosome	R-HSA-180292	1.842826e-01	0.735	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	1.842826e-01	0.735	0	0
PKA activation	R-HSA-163615	1.842826e-01	0.735	0	0
FGFR2 alternative splicing	R-HSA-6803529	1.626324e-01	0.789	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	1.626324e-01	0.789	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	2.760290e-01	0.559	0	0
Signaling by APC mutants	R-HSA-4839744	2.760290e-01	0.559	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	2.760290e-01	0.559	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	2.760290e-01	0.559	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	2.760290e-01	0.559	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	2.373720e-01	0.625	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	2.373720e-01	0.625	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	2.066333e-01	0.685	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	2.654619e-01	0.576	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	3.112009e-01	0.507	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	3.112009e-01	0.507	0	0
Activation of RAC1	R-HSA-428540	3.112009e-01	0.507	0	0
PI3K events in ERBB4 signaling	R-HSA-1250342	3.112009e-01	0.507	0	0
Activation of TRKA receptors	R-HSA-187015	3.744440e-01	0.427	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	3.744440e-01	0.427	0	0
MET activates PI3K/AKT signaling	R-HSA-8851907	3.744440e-01	0.427	0	0
PTK6 Expression	R-HSA-8849473	3.744440e-01	0.427	0	0
VLDL clearance	R-HSA-8964046	3.744440e-01	0.427	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	3.744440e-01	0.427	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	3.744440e-01	0.427	0	0
SOS-mediated signalling	R-HSA-112412	3.744440e-01	0.427	0	0
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.520566e-01	0.818	0	0
Dual Incision in GG-NER	R-HSA-5696400	1.714626e-01	0.766	0	0
HIV Transcription Elongation	R-HSA-167169	1.657878e-01	0.780	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.657878e-01	0.780	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	2.941131e-01	0.531	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	2.941131e-01	0.531	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	2.941131e-01	0.531	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	1.600040e-01	0.796	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	2.420243e-01	0.616	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	3.464836e-01	0.460	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	3.464836e-01	0.460	0	0
Polymerase switching	R-HSA-69091	3.464836e-01	0.460	0	0
Leading Strand Synthesis	R-HSA-69109	3.464836e-01	0.460	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	1.731236e-01	0.762	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	2.634671e-01	0.579	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	2.634671e-01	0.579	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	4.198407e-01	0.377	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	4.198407e-01	0.377	0	0
Formyl peptide receptors bind formyl peptides and many other ligands	R-HSA-444473	4.198407e-01	0.377	0	0
Formation of annular gap junctions	R-HSA-196025	4.198407e-01	0.377	0	0
Activated NTRK2 signals through PI3K	R-HSA-9028335	4.198407e-01	0.377	0	0
Stabilization of p53	R-HSA-69541	2.552754e-01	0.593	1	1
PKA activation in glucagon signalling	R-HSA-164378	3.523225e-01	0.453	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	1.790180e-01	0.747	0	0
Dual incision in TC-NER	R-HSA-6782135	2.477857e-01	0.606	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	3.536578e-01	0.451	0	0
Deadenylation of mRNA	R-HSA-429947	3.536578e-01	0.451	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	3.536578e-01	0.451	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	3.815220e-01	0.418	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	3.815220e-01	0.418	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	4.162439e-01	0.381	0	0
MAP2K and MAPK activation	R-HSA-5674135	3.106700e-01	0.508	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	2.776950e-01	0.556	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	2.776950e-01	0.556	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	2.776950e-01	0.556	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	2.776950e-01	0.556	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	2.776950e-01	0.556	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	3.758251e-01	0.425	0	0
Erythropoietin activates RAS	R-HSA-9027284	4.502480e-01	0.347	0	0
RNA Polymerase III Chain Elongation	R-HSA-73780	4.502480e-01	0.347	0	0
G beta:gamma signalling through BTK	R-HSA-8964315	4.502480e-01	0.347	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	3.264823e-01	0.486	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	3.603328e-01	0.443	0	0
mRNA 3'-end processing	R-HSA-72187	3.824232e-01	0.417	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	4.070787e-01	0.390	0	0
Chaperonin-mediated protein folding	R-HSA-390466	3.734696e-01	0.428	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	4.265176e-01	0.370	0	0
Translation initiation complex formation	R-HSA-72649	4.188631e-01	0.378	0	0
Transcription of the HIV genome	R-HSA-167172	4.052334e-01	0.392	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	3.824886e-01	0.417	0	0
Neutrophil degranulation	R-HSA-6798695	3.345424e-01	0.476	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	4.179737e-01	0.379	0	0
Protein folding	R-HSA-391251	3.551141e-01	0.450	0	0
Signaling by NOTCH2	R-HSA-1980145	4.442960e-01	0.352	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	2.375298e-01	0.624	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	3.244087e-01	0.489	1	0
Downstream signal transduction	R-HSA-186763	2.122140e-01	0.673	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.918972e-01	0.535	0	0
Signaling by NOTCH1	R-HSA-1980143	2.135402e-01	0.671	0	0
MET promotes cell motility	R-HSA-8875878	3.721025e-01	0.429	0	0
Lagging Strand Synthesis	R-HSA-69186	2.536954e-01	0.596	0	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	3.282856e-01	0.484	1	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	3.282856e-01	0.484	1	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	2.913316e-01	0.536	1	0
Signaling by Leptin	R-HSA-2586552	2.413007e-01	0.617	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	1.585536e-01	0.800	0	0
Generation of second messenger molecules	R-HSA-202433	4.140164e-01	0.383	0	0
Signalling to ERKs	R-HSA-187687	1.871496e-01	0.728	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	3.076470e-01	0.512	0	0
HSF1-dependent transactivation	R-HSA-3371571	2.455137e-01	0.610	0	0
Processive synthesis on the lagging strand	R-HSA-69183	2.373720e-01	0.625	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	1.731236e-01	0.762	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	1.731236e-01	0.762	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	2.771001e-01	0.557	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	1.639574e-01	0.785	0	0
Interleukin-35 Signalling	R-HSA-8984722	1.585536e-01	0.800	0	0
Pexophagy	R-HSA-9664873	2.413007e-01	0.617	1	1
Frs2-mediated activation	R-HSA-170968	3.815831e-01	0.418	0	0
Signaling by FGFR3	R-HSA-5654741	3.876272e-01	0.412	0	0
Josephin domain DUBs	R-HSA-5689877	2.413007e-01	0.617	0	0
EGFR Transactivation by Gastrin	R-HSA-2179392	2.413007e-01	0.617	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	2.373720e-01	0.625	0	0
Interleukin-23 signaling	R-HSA-9020933	4.198407e-01	0.377	0	0
Axonal growth inhibition (RHOA activation)	R-HSA-193634	4.198407e-01	0.377	0	0
DARPP-32 events	R-HSA-180024	3.076470e-01	0.512	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	3.106700e-01	0.508	0	0
Integrin signaling	R-HSA-354192	3.987204e-01	0.399	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	4.215684e-01	0.375	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	3.962746e-01	0.402	0	0
Signaling by FGFR4	R-HSA-5654743	3.488785e-01	0.457	0	0
Signaling by FGFR2	R-HSA-5654738	2.636098e-01	0.579	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	2.654619e-01	0.576	0	0
Signal transduction by L1	R-HSA-445144	4.105684e-01	0.387	0	0
UCH proteinases	R-HSA-5689603	4.146606e-01	0.382	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	1.801900e-01	0.744	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	1.801900e-01	0.744	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	2.073861e-01	0.683	0	0
Formation of lateral plate mesoderm	R-HSA-9758920	2.799808e-01	0.553	0	0
Regulation of CDH11 function	R-HSA-9762292	2.413007e-01	0.617	0	0
Polo-like kinase mediated events	R-HSA-156711	1.842826e-01	0.735	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	2.781478e-01	0.556	0	0
Attenuation phase	R-HSA-3371568	2.734150e-01	0.563	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	2.918972e-01	0.535	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	3.536578e-01	0.451	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	4.105684e-01	0.387	0	0
Signalling to RAS	R-HSA-167044	4.393181e-01	0.357	0	0
Signal amplification	R-HSA-392518	4.442960e-01	0.352	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	4.128081e-01	0.384	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	2.202282e-01	0.657	0	0
PTEN Regulation	R-HSA-6807070	1.749615e-01	0.757	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	2.066333e-01	0.685	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	2.654619e-01	0.576	0	0
Killing mechanisms	R-HSA-9664420	2.654619e-01	0.576	0	0
Signaling by RAS mutants	R-HSA-6802949	1.731236e-01	0.762	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.781478e-01	0.556	0	0
Interleukin-6 family signaling	R-HSA-6783589	2.008799e-01	0.697	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	2.930252e-01	0.533	0	0
Growth hormone receptor signaling	R-HSA-982772	1.813525e-01	0.741	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	1.813525e-01	0.741	0	0
Trafficking of AMPA receptors	R-HSA-399719	3.529597e-01	0.452	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	3.071635e-01	0.513	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	4.265176e-01	0.370	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	4.118044e-01	0.385	0	0
Signaling by PDGF	R-HSA-186797	4.290113e-01	0.368	0	0
Synthesis of DNA	R-HSA-69239	2.953472e-01	0.530	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	3.526118e-01	0.453	0	0
Fanconi Anemia Pathway	R-HSA-6783310	1.600040e-01	0.796	0	0
Nuclear RNA decay	R-HSA-9930044	2.499729e-01	0.602	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	4.297439e-01	0.367	0	0
Signaling by ROBO receptors	R-HSA-376176	3.744244e-01	0.427	0	0
Signal attenuation	R-HSA-74749	2.413007e-01	0.617	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	3.302055e-01	0.481	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	1.903635e-01	0.720	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	2.618005e-01	0.582	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	3.191160e-01	0.496	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	2.618005e-01	0.582	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	2.618005e-01	0.582	0	0
MET activates RAS signaling	R-HSA-8851805	3.464836e-01	0.460	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	2.088161e-01	0.680	0	0
Circadian clock	R-HSA-9909396	2.261410e-01	0.646	0	0
MAPK family signaling cascades	R-HSA-5683057	1.644623e-01	0.784	0	0
Regulation of CDH1 Function	R-HSA-9764561	3.433381e-01	0.464	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	4.070787e-01	0.390	0	0
HCMV Infection	R-HSA-9609646	2.281556e-01	0.642	0	0
Activation and oligomerization of BAK protein	R-HSA-111452	2.294979e-01	0.639	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	2.202282e-01	0.657	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	3.231286e-01	0.491	0	0
Platelet sensitization by LDL	R-HSA-432142	3.523225e-01	0.453	0	0
Syndecan interactions	R-HSA-3000170	3.282528e-01	0.484	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	3.529597e-01	0.452	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	3.791411e-01	0.421	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	4.442960e-01	0.352	0	0
Intraflagellar transport	R-HSA-5620924	4.458979e-01	0.351	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	4.476782e-01	0.349	0	0
MAP kinase activation	R-HSA-450294	2.930486e-01	0.533	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	2.434525e-01	0.614	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	2.420243e-01	0.616	0	0
Signaling by WNT	R-HSA-195721	2.577604e-01	0.589	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.776652e-01	0.750	0	0
Regulation of NF-kappa B signaling	R-HSA-9758274	2.654619e-01	0.576	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	3.680329e-01	0.434	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	4.055165e-01	0.392	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	4.502480e-01	0.347	0	0
TCR signaling	R-HSA-202403	3.311922e-01	0.480	0	0
Protein-protein interactions at synapses	R-HSA-6794362	1.639574e-01	0.785	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	2.298139e-01	0.639	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	3.231286e-01	0.491	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	4.198407e-01	0.377	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	1.992500e-01	0.701	0	0
Activation of BAD and translocation to mitochondria	R-HSA-111447	4.502480e-01	0.347	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	4.045929e-01	0.393	0	0
Interleukin-17 signaling	R-HSA-448424	4.379162e-01	0.359	0	0
Mismatch Repair	R-HSA-5358508	3.523225e-01	0.453	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	1.790662e-01	0.747	0	0
HIV Life Cycle	R-HSA-162587	4.290996e-01	0.367	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	2.320651e-01	0.634	0	0
Neurofascin interactions	R-HSA-447043	3.276596e-01	0.485	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	3.987204e-01	0.399	0	0
Calmodulin induced events	R-HSA-111933	2.034194e-01	0.692	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	3.098753e-01	0.509	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	3.231286e-01	0.491	0	0
Other semaphorin interactions	R-HSA-416700	4.502480e-01	0.347	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	4.461886e-01	0.350	0	0
Spry regulation of FGF signaling	R-HSA-1295596	2.373720e-01	0.625	0	0
Rab regulation of trafficking	R-HSA-9007101	4.432887e-01	0.353	0	0
CaM pathway	R-HSA-111997	2.034194e-01	0.692	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	2.370277e-01	0.625	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	3.464836e-01	0.460	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	3.076470e-01	0.512	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	3.052098e-01	0.515	0	0
Interleukin-12 family signaling	R-HSA-447115	3.734696e-01	0.428	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	1.559103e-01	0.807	0	0
Ca-dependent events	R-HSA-111996	2.102255e-01	0.677	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	3.651016e-01	0.438	0	0
Activation, translocation and oligomerization of BAX	R-HSA-114294	2.294979e-01	0.639	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	2.294979e-01	0.639	0	0
SDK interactions	R-HSA-373756	2.294979e-01	0.639	0	0
Dopamine receptors	R-HSA-390651	1.847704e-01	0.733	0	0
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	3.236750e-01	0.490	0	0
NrCAM interactions	R-HSA-447038	2.320651e-01	0.634	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	2.320651e-01	0.634	0	0
Co-stimulation by ICOS	R-HSA-9927354	1.746889e-01	0.758	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	2.073861e-01	0.683	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	2.073861e-01	0.683	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	4.063458e-01	0.391	0	0
C6 deamination of adenosine	R-HSA-75102	4.063458e-01	0.391	0	0
Regulation of the apoptosome activity	R-HSA-9627069	2.413007e-01	0.617	0	0
Signaling by AXIN mutants	R-HSA-4839735	3.112009e-01	0.507	0	0
Signaling by AMER1 mutants	R-HSA-4839748	3.112009e-01	0.507	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	3.744440e-01	0.427	0	0
Disorders of Developmental Biology	R-HSA-9675151	2.941131e-01	0.531	0	0
Regulation of IFNG signaling	R-HSA-877312	3.464836e-01	0.460	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	4.198407e-01	0.377	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	3.815831e-01	0.418	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	1.959958e-01	0.708	0	0
Negative regulation of MET activity	R-HSA-6807004	4.105684e-01	0.387	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	3.987204e-01	0.399	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	3.987204e-01	0.399	0	0
G0 and Early G1	R-HSA-1538133	3.758251e-01	0.425	0	0
Host Interactions of HIV factors	R-HSA-162909	3.476397e-01	0.459	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	2.424986e-01	0.615	0	0
Interleukin-15 signaling	R-HSA-8983432	3.464836e-01	0.460	0	0
FLT3 Signaling	R-HSA-9607240	1.800801e-01	0.745	0	0
DAG and IP3 signaling	R-HSA-1489509	3.876272e-01	0.412	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	4.045929e-01	0.393	0	0
Protein methylation	R-HSA-8876725	2.373720e-01	0.625	0	0
tRNA modification in the mitochondrion	R-HSA-6787450	2.941131e-01	0.531	0	0
The NLRP3 inflammasome	R-HSA-844456	3.815220e-01	0.418	0	0
FLT3 signaling in disease	R-HSA-9682385	2.034194e-01	0.692	0	0
DNA Damage Reversal	R-HSA-73942	4.502480e-01	0.347	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	3.305933e-01	0.481	0	0
Interleukin-1 family signaling	R-HSA-446652	2.324134e-01	0.634	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	2.413007e-01	0.617	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	3.276596e-01	0.485	0	0
Suppression of apoptosis	R-HSA-9635465	2.760290e-01	0.559	0	0
DAP12 interactions	R-HSA-2172127	3.682107e-01	0.434	0	0
Adaptive Immune System	R-HSA-1280218	4.112639e-01	0.386	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	1.752972e-01	0.756	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	3.471753e-01	0.459	0	0
Formation of apoptosome	R-HSA-111458	2.413007e-01	0.617	0	0
CHL1 interactions	R-HSA-447041	3.744440e-01	0.427	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	1.731236e-01	0.762	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	3.815831e-01	0.418	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	1.800801e-01	0.745	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	4.461886e-01	0.350	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	4.069647e-01	0.390	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	3.930578e-01	0.406	0	0
Interleukin-2 family signaling	R-HSA-451927	2.734150e-01	0.563	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	4.393181e-01	0.357	0	0
Gap junction trafficking	R-HSA-190828	2.422233e-01	0.616	0	0
Co-inhibition by PD-1	R-HSA-389948	3.466157e-01	0.460	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	1.751987e-01	0.756	0	0
Activation of RAC1 downstream of NMDARs	R-HSA-9619229	2.073861e-01	0.683	0	0
DSCAM interactions	R-HSA-376172	4.063458e-01	0.391	0	0
RHOBTB3 ATPase cycle	R-HSA-9706019	2.760290e-01	0.559	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	3.112009e-01	0.507	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	3.464836e-01	0.460	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	3.523225e-01	0.453	0	0
Signaling by FGFR4 in disease	R-HSA-5655291	4.162439e-01	0.381	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	3.987204e-01	0.399	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.393181e-01	0.357	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	4.299109e-01	0.367	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	4.045929e-01	0.393	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	1.730915e-01	0.762	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	4.198407e-01	0.377	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.373720e-01	0.625	0	0
Activated NTRK2 signals through FYN	R-HSA-9032500	4.198407e-01	0.377	0	0
Potential therapeutics for SARS	R-HSA-9679191	2.152622e-01	0.667	0	0
Nectin/Necl trans heterodimerization	R-HSA-420597	2.320651e-01	0.634	0	0
Butyrophilin (BTN) family interactions	R-HSA-8851680	2.073861e-01	0.683	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	3.744440e-01	0.427	0	0
MECP2 regulates transcription factors	R-HSA-9022707	3.744440e-01	0.427	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	1.800801e-01	0.745	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	3.621653e-01	0.441	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	4.299109e-01	0.367	0	0
MITF-M-dependent gene expression	R-HSA-9856651	1.608488e-01	0.794	0	0
Specification of primordial germ cells	R-HSA-9827857	3.231286e-01	0.491	0	0
Regulation of CDH19 Expression and Function	R-HSA-9764302	2.799808e-01	0.553	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	3.744440e-01	0.427	0	0
Basigin interactions	R-HSA-210991	4.393181e-01	0.357	0	0
Gap junction assembly	R-HSA-190861	2.895610e-01	0.538	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	3.523225e-01	0.453	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	2.895610e-01	0.538	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	3.815831e-01	0.418	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	4.162439e-01	0.381	0	0
Amyloid fiber formation	R-HSA-977225	3.783790e-01	0.422	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	3.930578e-01	0.406	0	0
Post-translational protein phosphorylation	R-HSA-8957275	4.516694e-01	0.345	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	4.550002e-01	0.342	0	0
Formation of the Early Elongation Complex	R-HSA-113418	4.550002e-01	0.342	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	4.550002e-01	0.342	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	4.552131e-01	0.342	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.552131e-01	0.342	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	4.557135e-01	0.341	0	0
G1/S Transition	R-HSA-69206	4.611274e-01	0.336	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	4.634899e-01	0.334	0	0
ARMS-mediated activation	R-HSA-170984	4.634899e-01	0.334	0	0
Lipophagy	R-HSA-9613354	4.634899e-01	0.334	0	0
WNT mediated activation of DVL	R-HSA-201688	4.634899e-01	0.334	0	0
Gap junction degradation	R-HSA-190873	4.634899e-01	0.334	0	0
p75NTR regulates axonogenesis	R-HSA-193697	4.634899e-01	0.334	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	4.634899e-01	0.334	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	4.634899e-01	0.334	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	4.634899e-01	0.334	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	4.634899e-01	0.334	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	4.634899e-01	0.334	0	0
Degradation of CDH1	R-HSA-9766229	4.651758e-01	0.332	0	0
PERK regulates gene expression	R-HSA-381042	4.668347e-01	0.331	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	4.676428e-01	0.330	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	4.676428e-01	0.330	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	4.676428e-01	0.330	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	4.676428e-01	0.330	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	4.676428e-01	0.330	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	4.676428e-01	0.330	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	4.684590e-01	0.329	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	4.684590e-01	0.329	0	0
SARS-CoV-1 Infection	R-HSA-9678108	4.700736e-01	0.328	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	4.768877e-01	0.322	0	0
MET activates STAT3	R-HSA-8875791	4.789155e-01	0.320	0	0
PLC-gamma1 signalling	R-HSA-167021	4.789155e-01	0.320	0	0
Axonal growth stimulation	R-HSA-209563	4.789155e-01	0.320	0	0
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	R-HSA-9673766	4.789155e-01	0.320	0	0
Defective ABCD4 causes MAHCJ	R-HSA-5683329	4.789155e-01	0.320	0	0
MET activates PTPN11	R-HSA-8865999	4.789155e-01	0.320	0	0
Invadopodia formation	R-HSA-8941237	4.789155e-01	0.320	0	0
STAT6-mediated induction of chemokines	R-HSA-3249367	4.789155e-01	0.320	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	4.789155e-01	0.320	0	0
Loss of MECP2 binding ability to 5mC-DNA	R-HSA-9022538	4.789155e-01	0.320	0	0
MET interacts with TNS proteins	R-HSA-8875513	4.789155e-01	0.320	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	4.789155e-01	0.320	0	0
Histamine receptors	R-HSA-390650	4.789155e-01	0.320	0	0
Signaling by Erythropoietin	R-HSA-9006335	4.797743e-01	0.319	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	4.797743e-01	0.319	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	4.797743e-01	0.319	0	0
Signaling by Interleukins	R-HSA-449147	4.801197e-01	0.319	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	4.803314e-01	0.318	0	0
Parasite infection	R-HSA-9664407	4.823165e-01	0.317	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	4.823165e-01	0.317	0	0
Leishmania phagocytosis	R-HSA-9664417	4.823165e-01	0.317	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	4.834127e-01	0.316	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	4.834127e-01	0.316	0	0
Phosphorylation of the APC/C	R-HSA-176412	4.834127e-01	0.316	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	4.834127e-01	0.316	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	4.834127e-01	0.316	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	4.834127e-01	0.316	0	0
Switching of origins to a post-replicative state	R-HSA-69052	4.866212e-01	0.313	0	0
HSF1 activation	R-HSA-3371511	4.891213e-01	0.311	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	4.938734e-01	0.306	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	4.954296e-01	0.305	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	4.954296e-01	0.305	0	0
LDL clearance	R-HSA-8964038	4.954296e-01	0.305	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	4.954296e-01	0.305	0	0
TBC/RABGAPs	R-HSA-8854214	4.967634e-01	0.304	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	5.041547e-01	0.297	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	5.041547e-01	0.297	0	0
Thrombin signalling through proteinase activated receptors (PARs)	R-HSA-456926	5.041547e-01	0.297	0	0
Activation of BH3-only proteins	R-HSA-114452	5.041547e-01	0.297	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	5.051408e-01	0.297	0	0
2-LTR circle formation	R-HSA-164843	5.051408e-01	0.297	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	5.051408e-01	0.297	0	0
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	5.051408e-01	0.297	0	0
MAPK3 (ERK1) activation	R-HSA-110056	5.051408e-01	0.297	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	5.051408e-01	0.297	0	0
Formation of intermediate mesoderm	R-HSA-9761174	5.051408e-01	0.297	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	5.059511e-01	0.296	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	5.059511e-01	0.296	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	5.110973e-01	0.291	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	5.155886e-01	0.288	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	5.155886e-01	0.288	0	0
Orc1 removal from chromatin	R-HSA-68949	5.219911e-01	0.282	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	5.219911e-01	0.282	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.225804e-01	0.282	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.225804e-01	0.282	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	5.225804e-01	0.282	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	5.280715e-01	0.277	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	5.332921e-01	0.273	0	0
Opioid Signalling	R-HSA-111885	5.336920e-01	0.273	0	0
Interleukin-12 signaling	R-HSA-9020591	5.343385e-01	0.272	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	5.367887e-01	0.270	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	5.367887e-01	0.270	0	0
RAF/MAP kinase cascade	R-HSA-5673001	5.392149e-01	0.268	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	5.396161e-01	0.268	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	5.404676e-01	0.267	0	0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	5.426179e-01	0.266	0	0
Signaling by MAP2K mutants	R-HSA-9652169	5.426179e-01	0.266	0	0
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	R-HSA-69200	5.426179e-01	0.266	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	5.426179e-01	0.266	0	0
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	5.426179e-01	0.266	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	5.426179e-01	0.266	0	0
TNFR1-mediated ceramide production	R-HSA-5626978	5.426179e-01	0.266	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	5.426179e-01	0.266	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	5.426179e-01	0.266	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	5.426179e-01	0.266	0	0
SARS-CoV-2 targets PDZ proteins in cell-cell junction	R-HSA-9705677	5.426179e-01	0.266	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	5.426179e-01	0.266	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	5.426179e-01	0.266	0	0
FLT3 signaling through SRC family kinases	R-HSA-9706374	5.426179e-01	0.266	0	0
Formation of paraxial mesoderm	R-HSA-9793380	5.438431e-01	0.265	0	0
PLC beta mediated events	R-HSA-112043	5.438431e-01	0.265	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	5.446296e-01	0.264	0	0
Alpha-protein kinase 1 signaling pathway	R-HSA-9645460	5.446296e-01	0.264	0	0
vRNP Assembly	R-HSA-192905	5.446296e-01	0.264	0	0
PECAM1 interactions	R-HSA-210990	5.446296e-01	0.264	0	0
Bicarbonate transporters	R-HSA-425381	5.446296e-01	0.264	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	5.446296e-01	0.264	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	5.466565e-01	0.262	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	5.466565e-01	0.262	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	5.466565e-01	0.262	0	0
Complex III assembly	R-HSA-9865881	5.490118e-01	0.260	0	0
Inositol phosphate metabolism	R-HSA-1483249	5.498024e-01	0.260	0	0
Hemostasis	R-HSA-109582	5.511236e-01	0.259	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	5.563145e-01	0.255	0	0
Signaling by FGFR	R-HSA-190236	5.578502e-01	0.253	0	0
PCP/CE pathway	R-HSA-4086400	5.653024e-01	0.248	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	5.673936e-01	0.246	0	0
Regulation of necroptotic cell death	R-HSA-5675482	5.742755e-01	0.241	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	5.742755e-01	0.241	0	0
Cardiogenesis	R-HSA-9733709	5.742755e-01	0.241	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	5.746538e-01	0.241	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	5.746580e-01	0.241	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	5.746580e-01	0.241	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	5.746580e-01	0.241	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	5.746580e-01	0.241	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	5.754685e-01	0.240	0	0
RNA Polymerase III Transcription Termination	R-HSA-73980	5.765245e-01	0.239	0	0
Tie2 Signaling	R-HSA-210993	5.765245e-01	0.239	0	0
Apoptotic factor-mediated response	R-HSA-111471	5.765245e-01	0.239	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	5.765346e-01	0.239	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	5.818626e-01	0.235	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	5.818626e-01	0.235	0	0
ERKs are inactivated	R-HSA-202670	5.818626e-01	0.235	0	0
Integration of provirus	R-HSA-162592	5.818626e-01	0.235	0	0
Hedgehog 'off' state	R-HSA-5610787	5.848060e-01	0.233	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	5.940702e-01	0.226	0	0
Signaling by FGFR1	R-HSA-5654736	5.940702e-01	0.226	0	0
TNF signaling	R-HSA-75893	5.940702e-01	0.226	0	0
GPER1 signaling	R-HSA-9634597	5.942196e-01	0.226	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	5.942861e-01	0.226	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	5.947561e-01	0.226	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	5.949141e-01	0.226	0	0
HCMV Late Events	R-HSA-9610379	5.963098e-01	0.225	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	5.964631e-01	0.224	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	5.964631e-01	0.224	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	5.980254e-01	0.223	0	0
IRS activation	R-HSA-74713	5.985359e-01	0.223	0	0
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	5.985359e-01	0.223	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	5.985359e-01	0.223	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	5.985359e-01	0.223	0	0
PTK6 Activates STAT3	R-HSA-8849474	5.985359e-01	0.223	0	0
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	5.985359e-01	0.223	0	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	5.985359e-01	0.223	0	0
PTK6 Down-Regulation	R-HSA-8849472	5.985359e-01	0.223	0	0
Reelin signalling pathway	R-HSA-8866376	5.985359e-01	0.223	0	0
NTRK2 activates RAC1	R-HSA-9032759	5.985359e-01	0.223	0	0
Muscarinic acetylcholine receptors	R-HSA-390648	5.985359e-01	0.223	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	5.985359e-01	0.223	0	0
Co-inhibition by BTLA	R-HSA-9927353	5.985359e-01	0.223	0	0
Assembly of Viral Components at the Budding Site	R-HSA-168316	5.985359e-01	0.223	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	5.994498e-01	0.222	0	0
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	5.994498e-01	0.222	0	0
Translesion Synthesis by POLH	R-HSA-110320	6.051253e-01	0.218	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	6.051253e-01	0.218	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	6.051253e-01	0.218	0	0
Germ layer formation at gastrulation	R-HSA-9754189	6.051253e-01	0.218	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	6.051253e-01	0.218	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	6.051253e-01	0.218	0	0
Other interleukin signaling	R-HSA-449836	6.051253e-01	0.218	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	6.051253e-01	0.218	0	0
HIV Infection	R-HSA-162906	6.082715e-01	0.216	0	0
PI Metabolism	R-HSA-1483255	6.110569e-01	0.214	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	6.112415e-01	0.214	0	0
SARS-CoV Infections	R-HSA-9679506	6.128174e-01	0.213	0	0
Intra-Golgi traffic	R-HSA-6811438	6.146466e-01	0.211	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	6.168011e-01	0.210	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	6.168011e-01	0.210	0	0
GRB2 events in EGFR signaling	R-HSA-179812	6.168011e-01	0.210	0	0
Scavenging by Class F Receptors	R-HSA-3000484	6.168011e-01	0.210	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	6.168011e-01	0.210	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	6.168011e-01	0.210	0	0
Disorders of Nervous System Development	R-HSA-9697154	6.168011e-01	0.210	0	0
Pervasive developmental disorders	R-HSA-9005895	6.168011e-01	0.210	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	6.179876e-01	0.209	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	6.179876e-01	0.209	1	1
Negative regulation of FGFR2 signaling	R-HSA-5654727	6.179876e-01	0.209	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	6.179876e-01	0.209	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	6.233550e-01	0.205	0	0
Cristae formation	R-HSA-8949613	6.233550e-01	0.205	0	0
Signaling by BMP	R-HSA-201451	6.233550e-01	0.205	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	6.233550e-01	0.205	0	0
Insulin processing	R-HSA-264876	6.233550e-01	0.205	0	0
Maturation of hRSV A proteins	R-HSA-9828806	6.233550e-01	0.205	0	0
Signaling by NOTCH4	R-HSA-9013694	6.252521e-01	0.204	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	6.304070e-01	0.200	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	6.324134e-01	0.199	0	0
Co-inhibition by CTLA4	R-HSA-389513	6.324134e-01	0.199	0	0
Formation of definitive endoderm	R-HSA-9823730	6.324134e-01	0.199	0	0
Protein hydroxylation	R-HSA-9629569	6.324134e-01	0.199	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	6.324134e-01	0.199	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	6.338281e-01	0.198	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	6.338281e-01	0.198	0	0
Non-integrin membrane-ECM interactions	R-HSA-3000171	6.400449e-01	0.194	0	0
G-protein mediated events	R-HSA-112040	6.419048e-01	0.193	0	0
Extension of Telomeres	R-HSA-180786	6.444109e-01	0.191	0	0
Inflammasomes	R-HSA-622312	6.463359e-01	0.190	0	0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	6.476204e-01	0.189	0	0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	6.476204e-01	0.189	0	0
NGF-independant TRKA activation	R-HSA-187024	6.476204e-01	0.189	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	6.476204e-01	0.189	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	6.476204e-01	0.189	0	0
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	6.476204e-01	0.189	0	0
Phosphorylation of Emi1	R-HSA-176417	6.476204e-01	0.189	0	0
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	6.476204e-01	0.189	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	6.476204e-01	0.189	0	0
Signaling by MAPK mutants	R-HSA-9652817	6.476204e-01	0.189	0	0
Signaling by MST1	R-HSA-8852405	6.476204e-01	0.189	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	6.476204e-01	0.189	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	6.476204e-01	0.189	0	0
Proton/oligopeptide cotransporters	R-HSA-427975	6.476204e-01	0.189	0	0
Ceramide signalling	R-HSA-193681	6.476204e-01	0.189	0	0
Release of Hh-Np from the secreting cell	R-HSA-5362798	6.476204e-01	0.189	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	6.476204e-01	0.189	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	6.476204e-01	0.189	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	6.476204e-01	0.189	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	6.476204e-01	0.189	0	0
Adenylate cyclase activating pathway	R-HSA-170660	6.494496e-01	0.187	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	6.494496e-01	0.187	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	6.494496e-01	0.187	0	0
Formation of axial mesoderm	R-HSA-9796292	6.494496e-01	0.187	0	0
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	6.494496e-01	0.187	0	0
CD28 dependent Vav1 pathway	R-HSA-389359	6.494496e-01	0.187	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	6.494496e-01	0.187	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	6.494496e-01	0.187	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	6.574694e-01	0.182	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	6.583621e-01	0.182	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	6.592437e-01	0.181	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	6.646990e-01	0.177	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	6.646990e-01	0.177	0	0
Influenza Infection	R-HSA-168255	6.669265e-01	0.176	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	6.683690e-01	0.175	0	0
Late endosomal microautophagy	R-HSA-9615710	6.683690e-01	0.175	0	0
mRNA Capping	R-HSA-72086	6.683690e-01	0.175	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	6.759066e-01	0.170	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	6.798457e-01	0.168	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	6.798457e-01	0.168	0	0
Synthesis of IPs in the nucleus	R-HSA-1855191	6.798457e-01	0.168	0	0
CRMPs in Sema3A signaling	R-HSA-399956	6.798457e-01	0.168	0	0
Physiological factors	R-HSA-5578768	6.798457e-01	0.168	0	0
Zinc transporters	R-HSA-435354	6.798457e-01	0.168	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	6.810933e-01	0.167	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	6.830178e-01	0.166	0	0
Glycolysis	R-HSA-70171	6.868418e-01	0.163	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	6.878609e-01	0.162	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	6.894399e-01	0.162	0	0
VLDL assembly	R-HSA-8866423	6.907061e-01	0.161	0	0
Erythropoietin activates STAT5	R-HSA-9027283	6.907061e-01	0.161	0	0
STAT5 Activation	R-HSA-9645135	6.907061e-01	0.161	0	0
Autointegration results in viral DNA circles	R-HSA-177539	6.907061e-01	0.161	0	0
RAS signaling downstream of NF1 loss-of-function variants	R-HSA-6802953	6.907061e-01	0.161	0	0
Defective CHST14 causes EDS, musculocontractural type	R-HSA-3595174	6.907061e-01	0.161	0	0
Defective CHST3 causes SEDCJD	R-HSA-3595172	6.907061e-01	0.161	0	0
Branched-chain ketoacid dehydrogenase kinase deficiency	R-HSA-9912481	6.907061e-01	0.161	0	0
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	6.907061e-01	0.161	0	0
Small interfering RNA (siRNA) biogenesis	R-HSA-426486	6.907061e-01	0.161	0	0
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	6.907061e-01	0.161	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	6.907061e-01	0.161	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	6.907061e-01	0.161	0	0
Lactose synthesis	R-HSA-5653890	6.907061e-01	0.161	0	0
Metabolism of vitamin K	R-HSA-6806664	6.907061e-01	0.161	0	0
HDL clearance	R-HSA-8964011	6.907061e-01	0.161	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	6.909950e-01	0.161	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	6.909950e-01	0.161	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	6.958966e-01	0.157	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	6.962259e-01	0.157	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	6.969268e-01	0.157	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.969268e-01	0.157	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	6.969706e-01	0.157	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	6.972633e-01	0.157	0	0
Interleukin-1 signaling	R-HSA-9020702	6.986575e-01	0.156	0	0
Integration of energy metabolism	R-HSA-163685	6.997239e-01	0.155	0	0
Regulation of mitotic cell cycle	R-HSA-453276	7.002640e-01	0.155	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	7.002640e-01	0.155	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	7.046537e-01	0.152	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	7.062139e-01	0.151	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	7.062139e-01	0.151	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	7.062139e-01	0.151	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	7.062139e-01	0.151	0	0
Cellular hexose transport	R-HSA-189200	7.062139e-01	0.151	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	7.080521e-01	0.150	0	0
Adenylate cyclase inhibitory pathway	R-HSA-170670	7.080521e-01	0.150	0	0
SHC1 events in EGFR signaling	R-HSA-180336	7.080521e-01	0.150	0	0
Translesion synthesis by REV1	R-HSA-110312	7.080521e-01	0.150	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	7.080521e-01	0.150	0	0
p38MAPK events	R-HSA-171007	7.080521e-01	0.150	0	0
Biotin transport and metabolism	R-HSA-196780	7.080521e-01	0.150	0	0
SARS-CoV-2 targets host intracellular signalling and regulatory pathways	R-HSA-9755779	7.080521e-01	0.150	0	0
Formation of the dystrophin-glycoprotein complex (DGC)	R-HSA-9913351	7.095427e-01	0.149	0	0
Plasma lipoprotein clearance	R-HSA-8964043	7.147938e-01	0.146	0	0
rRNA processing	R-HSA-72312	7.156622e-01	0.145	0	0
Signaling by Hedgehog	R-HSA-5358351	7.193682e-01	0.143	0	0
Insulin receptor signalling cascade	R-HSA-74751	7.198095e-01	0.143	0	0
IGF1R signaling cascade	R-HSA-2428924	7.198095e-01	0.143	0	0
Parasitic Infection Pathways	R-HSA-9824443	7.208227e-01	0.142	0	0
Leishmania infection	R-HSA-9658195	7.208227e-01	0.142	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	7.208235e-01	0.142	0	0
Adipogenesis	R-HSA-9843745	7.213501e-01	0.142	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	7.217078e-01	0.142	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	7.277322e-01	0.138	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	7.281360e-01	0.138	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	7.281360e-01	0.138	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	7.281360e-01	0.138	0	0
Formation of the ureteric bud	R-HSA-9830674	7.281360e-01	0.138	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	7.285259e-01	0.138	0	0
PP2A-mediated dephosphorylation of key metabolic factors	R-HSA-163767	7.285259e-01	0.138	0	0
NOSTRIN mediated eNOS trafficking	R-HSA-203641	7.285259e-01	0.138	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	7.285259e-01	0.138	0	0
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	R-HSA-964827	7.285259e-01	0.138	0	0
Defective CHSY1 causes TPBS	R-HSA-3595177	7.285259e-01	0.138	0	0
Disinhibition of SNARE formation	R-HSA-114516	7.285259e-01	0.138	0	0
Recycling of eIF2:GDP	R-HSA-72731	7.285259e-01	0.138	0	0
Insulin effects increased synthesis of Xylulose-5-Phosphate	R-HSA-163754	7.285259e-01	0.138	0	0
LDL remodeling	R-HSA-8964041	7.285259e-01	0.138	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	7.285259e-01	0.138	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	7.285259e-01	0.138	0	0
SLC-mediated transport of oligopeptides	R-HSA-9959399	7.285259e-01	0.138	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	7.285259e-01	0.138	0	0
Defective HLCS causes multiple carboxylase deficiency	R-HSA-3371599	7.285259e-01	0.138	0	0
Activated NTRK2 signals through CDK5	R-HSA-9032845	7.285259e-01	0.138	0	0
Signaling by WNT in cancer	R-HSA-4791275	7.286785e-01	0.137	0	0
tRNA processing	R-HSA-72306	7.309470e-01	0.136	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	7.319013e-01	0.136	0	0
Diseases of Immune System	R-HSA-5260271	7.319013e-01	0.136	0	0
Cellular response to hypoxia	R-HSA-1234174	7.335244e-01	0.135	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	7.335244e-01	0.135	0	0
Regulation of BACH1 activity	R-HSA-9708530	7.341498e-01	0.134	0	0
Translesion synthesis by POLI	R-HSA-5656121	7.341498e-01	0.134	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	7.341498e-01	0.134	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	7.341498e-01	0.134	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	7.341498e-01	0.134	0	0
Negative regulation of FLT3	R-HSA-9706369	7.341498e-01	0.134	0	0
IRS-mediated signalling	R-HSA-112399	7.414321e-01	0.130	0	0
RSV-host interactions	R-HSA-9833110	7.431580e-01	0.129	0	0
G-protein beta:gamma signalling	R-HSA-397795	7.468547e-01	0.127	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	7.468547e-01	0.127	0	0
ADP signalling through P2Y purinoceptor 1	R-HSA-418592	7.487525e-01	0.126	0	0
Signaling by FLT3 ITD and TKD mutants	R-HSA-9703648	7.487525e-01	0.126	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	7.487525e-01	0.126	0	0
Post-translational protein modification	R-HSA-597592	7.492627e-01	0.125	0	0
Gastrulation	R-HSA-9758941	7.537713e-01	0.123	0	0
Translesion synthesis by POLK	R-HSA-5655862	7.582325e-01	0.120	0	0
Defective B4GALT7 causes EDS, progeroid type	R-HSA-3560783	7.582325e-01	0.120	0	0
Defective B3GALT6 causes EDSP2 and SEMDJL1	R-HSA-4420332	7.582325e-01	0.120	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	7.582325e-01	0.120	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	7.582325e-01	0.120	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	7.582325e-01	0.120	0	0
ALKBH3 mediated reversal of alkylation damage	R-HSA-112126	7.617232e-01	0.118	0	0
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.617232e-01	0.118	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	7.617232e-01	0.118	0	0
Activation of RAS in B cells	R-HSA-1169092	7.617232e-01	0.118	0	0
Nef mediated downregulation of MHC class I complex cell surface expression	R-HSA-164940	7.617232e-01	0.118	0	0
Regulation by c-FLIP	R-HSA-3371378	7.617232e-01	0.118	0	0
Fructose biosynthesis	R-HSA-5652227	7.617232e-01	0.118	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	7.617232e-01	0.118	0	0
Adrenoceptors	R-HSA-390696	7.617232e-01	0.118	0	0
Interleukin-9 signaling	R-HSA-8985947	7.617232e-01	0.118	0	0
Dimerization of procaspase-8	R-HSA-69416	7.617232e-01	0.118	0	0
TGFBR3 PTM regulation	R-HSA-9839383	7.617232e-01	0.118	0	0
phospho-PLA2 pathway	R-HSA-111995	7.617232e-01	0.118	0	0
RSK activation	R-HSA-444257	7.617232e-01	0.118	0	0
Sodium/Proton exchangers	R-HSA-425986	7.617232e-01	0.118	0	0
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	R-HSA-8866904	7.617232e-01	0.118	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	7.640845e-01	0.117	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	7.640845e-01	0.117	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.640845e-01	0.117	0	0
PI3K Cascade	R-HSA-109704	7.655776e-01	0.116	0	0
Toll-like Receptor Cascades	R-HSA-168898	7.677387e-01	0.115	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	7.680963e-01	0.115	0	0
Acyl chain remodelling of PS	R-HSA-1482801	7.680963e-01	0.115	0	0
TGFBR3 expression	R-HSA-9839394	7.680963e-01	0.115	0	0
Formation of the nephric duct	R-HSA-9830364	7.680963e-01	0.115	0	0
FOXO-mediated transcription	R-HSA-9614085	7.683567e-01	0.114	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	7.684058e-01	0.114	0	0
Signaling by Insulin receptor	R-HSA-74752	7.736667e-01	0.111	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	7.764736e-01	0.110	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.786242e-01	0.109	0	0
Cytosolic tRNA aminoacylation	R-HSA-379716	7.787042e-01	0.109	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	7.792527e-01	0.108	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	7.804028e-01	0.108	0	0
Defective B3GAT3 causes JDSSDHD	R-HSA-3560801	7.804028e-01	0.108	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	7.804028e-01	0.108	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	7.804028e-01	0.108	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	7.831061e-01	0.106	0	0
TRP channels	R-HSA-3295583	7.862070e-01	0.104	0	0
SARS-CoV-2 Infection	R-HSA-9694516	7.907941e-01	0.102	0	0
IRAK2 mediated activation of TAK1 complex	R-HSA-937042	7.908626e-01	0.102	0	0
CASP8 activity is inhibited	R-HSA-5218900	7.908626e-01	0.102	0	0
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	7.908626e-01	0.102	0	0
Calcineurin activates NFAT	R-HSA-2025928	7.908626e-01	0.102	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	7.908626e-01	0.102	0	0
Interleukin-21 signaling	R-HSA-9020958	7.908626e-01	0.102	0	0
mRNA Editing	R-HSA-75072	7.908626e-01	0.102	0	0
Regulation of signaling by NODAL	R-HSA-1433617	7.908626e-01	0.102	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	7.908626e-01	0.102	0	0
Interleukin-1 processing	R-HSA-448706	7.908626e-01	0.102	0	0
Defects in biotin (Btn) metabolism	R-HSA-3323169	7.908626e-01	0.102	0	0
Estrogen-stimulated signaling through PRKCZ	R-HSA-9634635	7.908626e-01	0.102	0	0
Cellular response to mitochondrial stress	R-HSA-9840373	7.908626e-01	0.102	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	7.923168e-01	0.101	0	0
Aquaporin-mediated transport	R-HSA-445717	7.932621e-01	0.101	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	7.951201e-01	0.100	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	7.957798e-01	0.099	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	7.957798e-01	0.099	0	0
Cap-dependent Translation Initiation	R-HSA-72737	7.965671e-01	0.099	0	0
Eukaryotic Translation Initiation	R-HSA-72613	7.965671e-01	0.099	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	8.007682e-01	0.096	0	0
G beta:gamma signalling through PLC beta	R-HSA-418217	8.007682e-01	0.096	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	8.007682e-01	0.096	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	8.007682e-01	0.096	0	0
Presynaptic function of Kainate receptors	R-HSA-500657	8.007682e-01	0.096	0	0
Amino acids regulate mTORC1	R-HSA-9639288	8.047797e-01	0.094	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	8.049100e-01	0.094	0	0
Cyclin D associated events in G1	R-HSA-69231	8.062375e-01	0.094	0	0
G1 Phase	R-HSA-69236	8.062375e-01	0.094	0	0
Amine ligand-binding receptors	R-HSA-375280	8.062375e-01	0.094	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	8.102920e-01	0.091	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	8.102920e-01	0.091	0	0
Triglyceride catabolism	R-HSA-163560	8.102920e-01	0.091	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	8.126524e-01	0.090	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	8.164399e-01	0.088	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	8.164399e-01	0.088	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	8.164399e-01	0.088	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	8.164399e-01	0.088	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	8.164399e-01	0.088	0	0
Ion influx/efflux at host-pathogen interface	R-HSA-6803544	8.164399e-01	0.088	0	0
DNA replication initiation	R-HSA-68952	8.164399e-01	0.088	0	0
Arachidonate production from DAG	R-HSA-426048	8.164399e-01	0.088	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	8.164399e-01	0.088	0	0
Maturation of spike protein	R-HSA-9683686	8.164399e-01	0.088	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	8.165492e-01	0.088	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	8.184717e-01	0.087	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	8.184717e-01	0.087	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	8.189096e-01	0.087	0	0
Insulin receptor recycling	R-HSA-77387	8.189096e-01	0.087	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.189096e-01	0.087	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	8.189475e-01	0.087	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	8.189475e-01	0.087	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	8.189475e-01	0.087	0	0
Somitogenesis	R-HSA-9824272	8.189475e-01	0.087	0	0
Prostacyclin signalling through prostacyclin receptor	R-HSA-392851	8.194385e-01	0.086	0	0
Specification of the neural plate border	R-HSA-9834899	8.194385e-01	0.086	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	8.194385e-01	0.086	0	0
Maturation of nucleoprotein	R-HSA-9694631	8.194385e-01	0.086	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	8.216827e-01	0.085	0	0
Degradation of DVL	R-HSA-4641258	8.239500e-01	0.084	0	0
Platelet degranulation	R-HSA-114608	8.245675e-01	0.084	0	0
Downstream TCR signaling	R-HSA-202424	8.286045e-01	0.082	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	8.309774e-01	0.080	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	8.309774e-01	0.080	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	8.309774e-01	0.080	0	0
Signaling by TGFBR3	R-HSA-9839373	8.309774e-01	0.080	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.336002e-01	0.079	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	8.365236e-01	0.078	0	0
Signaling by NODAL	R-HSA-1181150	8.365236e-01	0.078	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	8.368091e-01	0.077	0	0
Chylomicron assembly	R-HSA-8963888	8.388905e-01	0.076	0	0
Presynaptic depolarization and calcium channel opening	R-HSA-112308	8.388905e-01	0.076	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	8.388905e-01	0.076	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	8.388905e-01	0.076	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	8.388905e-01	0.076	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	8.388905e-01	0.076	0	0
Synthesis of PI	R-HSA-1483226	8.388905e-01	0.076	0	0
SARS-CoV-2 modulates autophagy	R-HSA-9754560	8.388905e-01	0.076	0	0
LGI-ADAM interactions	R-HSA-5682910	8.388905e-01	0.076	0	0
Inorganic anion exchange by SLC26 transporters	R-HSA-427601	8.388905e-01	0.076	0	0
Transport of RCbl within the body	R-HSA-9758890	8.388905e-01	0.076	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	8.388905e-01	0.076	0	0
Prostanoid ligand receptors	R-HSA-391908	8.388905e-01	0.076	0	0
Dissolution of Fibrin Clot	R-HSA-75205	8.388905e-01	0.076	0	0
Immune System	R-HSA-168256	8.443923e-01	0.073	0	0
Viral Infection Pathways	R-HSA-9824446	8.486801e-01	0.071	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.488241e-01	0.071	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	8.521319e-01	0.069	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	8.521319e-01	0.069	0	0
G-protein activation	R-HSA-202040	8.521319e-01	0.069	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	8.521319e-01	0.069	0	0
ERK/MAPK targets	R-HSA-198753	8.521319e-01	0.069	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	8.521319e-01	0.069	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	8.521319e-01	0.069	0	0
Vitamin C (ascorbate) metabolism	R-HSA-196836	8.521319e-01	0.069	0	0
Eukaryotic Translation Elongation	R-HSA-156842	8.536546e-01	0.069	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	8.557050e-01	0.068	0	0
DS-GAG biosynthesis	R-HSA-2022923	8.585964e-01	0.066	0	0
Scavenging by Class H Receptors	R-HSA-3000497	8.585964e-01	0.066	0	0
Condensation of Prometaphase Chromosomes	R-HSA-2514853	8.585964e-01	0.066	0	0
Synthesis of diphthamide-EEF2	R-HSA-5358493	8.585964e-01	0.066	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	8.585964e-01	0.066	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	8.585964e-01	0.066	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	8.585964e-01	0.066	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	8.585964e-01	0.066	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	8.585964e-01	0.066	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	8.585964e-01	0.066	0	0
Uptake of dietary cobalamins into enterocytes	R-HSA-9758881	8.585964e-01	0.066	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	8.599200e-01	0.066	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	8.601041e-01	0.065	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	8.613318e-01	0.065	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	8.663689e-01	0.062	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	8.663689e-01	0.062	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	8.663689e-01	0.062	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	8.692508e-01	0.061	0	0
Mitochondrial biogenesis	R-HSA-1592230	8.697616e-01	0.061	0	0
Glucose metabolism	R-HSA-70326	8.697616e-01	0.061	0	0
Developmental Biology	R-HSA-1266738	8.722738e-01	0.059	0	0
Regulation of RAS by GAPs	R-HSA-5658442	8.727218e-01	0.059	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.727641e-01	0.059	0	0
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	R-HSA-3656253	8.758930e-01	0.058	0	0
Defective EXT2 causes exostoses 2	R-HSA-3656237	8.758930e-01	0.058	0	0
VLDLR internalisation and degradation	R-HSA-8866427	8.758930e-01	0.058	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	8.758930e-01	0.058	0	0
Repression of WNT target genes	R-HSA-4641265	8.758930e-01	0.058	0	0
Activated NTRK2 signals through FRS2 and FRS3	R-HSA-9028731	8.758930e-01	0.058	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	8.758930e-01	0.058	0	0
Advanced glycosylation endproduct receptor signaling	R-HSA-879415	8.758930e-01	0.058	0	0
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	8.758930e-01	0.058	0	0
Estrogen biosynthesis	R-HSA-193144	8.758930e-01	0.058	0	0
OAS antiviral response	R-HSA-8983711	8.758930e-01	0.058	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	8.763042e-01	0.057	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	8.780650e-01	0.056	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	8.793366e-01	0.056	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	8.793366e-01	0.056	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	8.793366e-01	0.056	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	8.805164e-01	0.055	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	8.805164e-01	0.055	0	0
HIV Transcription Initiation	R-HSA-167161	8.805164e-01	0.055	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	8.805164e-01	0.055	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	8.806478e-01	0.055	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	8.806478e-01	0.055	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	8.816782e-01	0.055	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	8.819226e-01	0.055	0	0
Hedgehog 'on' state	R-HSA-5632684	8.881200e-01	0.052	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	8.881200e-01	0.052	0	0
Activation of GABAB receptors	R-HSA-991365	8.897160e-01	0.051	0	0
GABA B receptor activation	R-HSA-977444	8.897160e-01	0.051	0	0
Chylomicron remodeling	R-HSA-8963901	8.910747e-01	0.050	0	0
FGFR2c ligand binding and activation	R-HSA-190375	8.910747e-01	0.050	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	8.910747e-01	0.050	0	0
FGFR1c ligand binding and activation	R-HSA-190373	8.910747e-01	0.050	0	0
FGFR4 ligand binding and activation	R-HSA-190322	8.910747e-01	0.050	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	8.910747e-01	0.050	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	8.910747e-01	0.050	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	8.910747e-01	0.050	0	0
Processing of SMDT1	R-HSA-8949664	8.910747e-01	0.050	0	0
Golgi Cisternae Pericentriolar Stack Reorganization	R-HSA-162658	8.910747e-01	0.050	0	0
Maturation of nucleoprotein	R-HSA-9683610	8.910747e-01	0.050	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	8.911324e-01	0.050	0	0
Interleukin-20 family signaling	R-HSA-8854691	8.911324e-01	0.050	0	0
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	8.911324e-01	0.050	0	0
Miscellaneous transport and binding events	R-HSA-5223345	8.925436e-01	0.049	0	0
Transmission across Chemical Synapses	R-HSA-112315	8.955056e-01	0.048	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	8.979817e-01	0.047	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	8.982894e-01	0.047	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	9.017986e-01	0.045	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	9.018489e-01	0.045	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	9.018489e-01	0.045	0	0
Ca2+ pathway	R-HSA-4086398	9.018879e-01	0.045	0	0
Prolactin receptor signaling	R-HSA-1170546	9.044001e-01	0.044	0	0
FGFR3c ligand binding and activation	R-HSA-190372	9.044001e-01	0.044	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	9.044001e-01	0.044	0	0
Retrograde neurotrophin signalling	R-HSA-177504	9.044001e-01	0.044	0	0
cGMP effects	R-HSA-418457	9.044001e-01	0.044	0	0
N-glycan trimming and elongation in the cis-Golgi	R-HSA-964739	9.044001e-01	0.044	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	9.044001e-01	0.044	0	0
Respiratory syncytial virus genome transcription	R-HSA-9828642	9.044001e-01	0.044	0	0
Cytoprotection by HMOX1	R-HSA-9707564	9.049140e-01	0.043	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	9.053771e-01	0.043	0	0
Ion transport by P-type ATPases	R-HSA-936837	9.062718e-01	0.043	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.082132e-01	0.042	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.082550e-01	0.042	0	0
IRE1alpha activates chaperones	R-HSA-381070	9.082550e-01	0.042	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	9.085263e-01	0.042	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	9.103275e-01	0.041	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.103624e-01	0.041	0	0
Cellular response to chemical stress	R-HSA-9711123	9.111133e-01	0.040	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.115736e-01	0.040	0	0
G protein gated Potassium channels	R-HSA-1296059	9.115736e-01	0.040	0	0
Activation of G protein gated Potassium channels	R-HSA-1296041	9.115736e-01	0.040	0	0
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	9.115736e-01	0.040	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.115736e-01	0.040	0	0
MicroRNA (miRNA) biogenesis	R-HSA-203927	9.115736e-01	0.040	0	0
VEGFR2 mediated cell proliferation	R-HSA-5218921	9.115736e-01	0.040	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.115736e-01	0.040	0	0
G alpha (z) signalling events	R-HSA-418597	9.123000e-01	0.040	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	9.136897e-01	0.039	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	9.160960e-01	0.038	0	0
Protein lipoylation	R-HSA-9857492	9.160960e-01	0.038	0	0
FGFR3 ligand binding and activation	R-HSA-190239	9.160960e-01	0.038	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	9.160960e-01	0.038	0	0
Signaling by Activin	R-HSA-1502540	9.160960e-01	0.038	0	0
Formation of the anterior neural plate	R-HSA-9823739	9.160960e-01	0.038	0	0
Cellular response to starvation	R-HSA-9711097	9.173062e-01	0.037	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	9.173062e-01	0.037	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.181782e-01	0.037	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.187499e-01	0.037	0	0
MET activates PTK2 signaling	R-HSA-8874081	9.203887e-01	0.036	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	9.203887e-01	0.036	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	9.203887e-01	0.036	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.205809e-01	0.036	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.231190e-01	0.035	0	0
Kidney development	R-HSA-9830369	9.244262e-01	0.034	0	0
Degradation of AXIN	R-HSA-4641257	9.253964e-01	0.034	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	9.255683e-01	0.034	0	0
Atorvastatin ADME	R-HSA-9754706	9.263615e-01	0.033	0	0
Activation of the phototransduction cascade	R-HSA-2485179	9.263615e-01	0.033	0	0
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	R-HSA-9634600	9.263615e-01	0.033	0	0
Activation of SMO	R-HSA-5635838	9.263615e-01	0.033	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	9.263615e-01	0.033	0	0
Virus Assembly and Release	R-HSA-168268	9.263615e-01	0.033	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	9.283711e-01	0.032	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	9.283711e-01	0.032	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.283870e-01	0.032	0	0
Regulated Necrosis	R-HSA-5218859	9.297511e-01	0.032	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	9.304668e-01	0.031	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.320261e-01	0.031	0	0
Eukaryotic Translation Termination	R-HSA-72764	9.327800e-01	0.030	0	0
Metal ion SLC transporters	R-HSA-425410	9.329001e-01	0.030	0	0
Scavenging by Class B Receptors	R-HSA-3000471	9.353717e-01	0.029	0	0
Phase 2 - plateau phase	R-HSA-5576893	9.353717e-01	0.029	0	0
Glycine degradation	R-HSA-6783984	9.353717e-01	0.029	0	0
STAT5 activation downstream of FLT3 ITD mutants	R-HSA-9702518	9.353717e-01	0.029	0	0
Acetylcholine regulates insulin secretion	R-HSA-399997	9.353717e-01	0.029	0	0
Passive transport by Aquaporins	R-HSA-432047	9.353717e-01	0.029	0	0
Formation of xylulose-5-phosphate	R-HSA-5661270	9.353717e-01	0.029	0	0
Galactose catabolism	R-HSA-70370	9.353717e-01	0.029	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	9.353717e-01	0.029	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	9.355926e-01	0.029	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	9.355926e-01	0.029	0	0
Telomere Extension By Telomerase	R-HSA-171319	9.355926e-01	0.029	0	0
Pyrimidine salvage	R-HSA-73614	9.355926e-01	0.029	0	0
Peptide chain elongation	R-HSA-156902	9.356492e-01	0.029	0	0
Triglyceride metabolism	R-HSA-8979227	9.357301e-01	0.029	0	0
Regulation of beta-cell development	R-HSA-186712	9.357301e-01	0.029	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	9.381090e-01	0.028	0	0
COPII-mediated vesicle transport	R-HSA-204005	9.394155e-01	0.027	0	0
tRNA Aminoacylation	R-HSA-379724	9.406334e-01	0.027	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.421199e-01	0.026	0	0
Platelet homeostasis	R-HSA-418346	9.422400e-01	0.026	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	9.432798e-01	0.025	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	9.432798e-01	0.025	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	9.432798e-01	0.025	0	0
Sulfide oxidation to sulfate	R-HSA-1614517	9.432798e-01	0.025	0	0
Azathioprine ADME	R-HSA-9748787	9.434620e-01	0.025	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	9.436848e-01	0.025	0	0
Regulation of insulin secretion	R-HSA-422356	9.445835e-01	0.025	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	9.451971e-01	0.024	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.457436e-01	0.024	0	0
Interferon alpha/beta signaling	R-HSA-909733	9.471312e-01	0.024	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.480146e-01	0.023	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.480146e-01	0.023	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.481526e-01	0.023	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	9.487910e-01	0.023	0	0
Maturation of spike protein	R-HSA-9694548	9.487910e-01	0.023	0	0
Mitochondrial protein import	R-HSA-1268020	9.494411e-01	0.023	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.502207e-01	0.022	0	0
FGFR1 ligand binding and activation	R-HSA-190242	9.502207e-01	0.022	0	0
Activated point mutants of FGFR2	R-HSA-2033519	9.502207e-01	0.022	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	9.502207e-01	0.022	0	0
Interferon gamma signaling	R-HSA-877300	9.503879e-01	0.022	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.533339e-01	0.021	0	0
Cargo concentration in the ER	R-HSA-5694530	9.533339e-01	0.021	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.533339e-01	0.021	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	9.534630e-01	0.021	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	9.534630e-01	0.021	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	9.534630e-01	0.021	0	0
Selenocysteine synthesis	R-HSA-2408557	9.545245e-01	0.020	0	0
mRNA decay by 3' to 5' exoribonuclease	R-HSA-429958	9.563126e-01	0.019	0	0
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.563126e-01	0.019	0	0
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.563126e-01	0.019	0	0
Smooth Muscle Contraction	R-HSA-445355	9.564796e-01	0.019	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.570457e-01	0.019	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	9.581302e-01	0.019	0	0
Inwardly rectifying K+ channels	R-HSA-1296065	9.581302e-01	0.019	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.581302e-01	0.019	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.606045e-01	0.017	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	9.616352e-01	0.017	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.616352e-01	0.017	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	9.616592e-01	0.017	0	0
Mitochondrial iron-sulfur cluster biogenesis	R-HSA-1362409	9.616592e-01	0.017	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	9.616592e-01	0.017	0	0
Synthesis of Ketone Bodies	R-HSA-77111	9.616592e-01	0.017	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.616592e-01	0.017	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	9.616592e-01	0.017	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	9.624519e-01	0.017	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	9.645705e-01	0.016	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.651958e-01	0.015	0	0
Proteasome assembly	R-HSA-9907900	9.651958e-01	0.015	0	0
Surfactant metabolism	R-HSA-5683826	9.651958e-01	0.015	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.663432e-01	0.015	0	0
Vpu mediated degradation of CD4	R-HSA-180534	9.663432e-01	0.015	0	0
Vitamin B5 (pantothenate) metabolism	R-HSA-199220	9.663432e-01	0.015	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.663518e-01	0.015	0	0
FGFR2 ligand binding and activation	R-HSA-190241	9.663518e-01	0.015	0	0
PD-L1(CD274) glycosylation and translocation to plasma membrane	R-HSA-9931295	9.663518e-01	0.015	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.663518e-01	0.015	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.666784e-01	0.015	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	9.678629e-01	0.014	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.684431e-01	0.014	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	9.684431e-01	0.014	0	0
Muscle contraction	R-HSA-397014	9.687286e-01	0.014	0	0
Glycosaminoglycan-protein linkage region biosynthesis	R-HSA-1971475	9.698448e-01	0.013	0	0
eNOS activation	R-HSA-203615	9.698448e-01	0.013	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.698448e-01	0.013	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	9.698448e-01	0.013	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.698448e-01	0.013	0	0
Mitophagy	R-HSA-5205647	9.698448e-01	0.013	0	0
CS-GAG biosynthesis	R-HSA-2022870	9.704703e-01	0.013	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.704703e-01	0.013	0	0
Attachment and Entry	R-HSA-9694614	9.704703e-01	0.013	0	0
Ribavirin ADME	R-HSA-9755088	9.704703e-01	0.013	0	0
Glutathione synthesis and recycling	R-HSA-174403	9.704703e-01	0.013	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	9.704703e-01	0.013	0	0
Metabolism of Angiotensinogen to Angiotensins	R-HSA-2022377	9.704703e-01	0.013	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	9.721892e-01	0.012	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.729937e-01	0.012	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.729937e-01	0.012	0	0
Regulation of Apoptosis	R-HSA-169911	9.729937e-01	0.012	0	0
Transferrin endocytosis and recycling	R-HSA-917977	9.729937e-01	0.012	0	0
Defects in vitamin and cofactor metabolism	R-HSA-3296482	9.729937e-01	0.012	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	9.740850e-01	0.011	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.740850e-01	0.011	0	0
Fructose metabolism	R-HSA-5652084	9.740850e-01	0.011	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.740850e-01	0.011	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	9.740850e-01	0.011	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.746129e-01	0.011	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.747400e-01	0.011	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.749604e-01	0.011	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.758237e-01	0.011	0	0
G1/S-Specific Transcription	R-HSA-69205	9.758237e-01	0.011	0	0
GABA receptor activation	R-HSA-977443	9.768371e-01	0.010	0	0
Mitochondrial mRNA modification	R-HSA-9937008	9.772573e-01	0.010	0	0
ABC transporters in lipid homeostasis	R-HSA-1369062	9.772573e-01	0.010	0	0
Carnitine shuttle	R-HSA-200425	9.772573e-01	0.010	0	0
Ketone body metabolism	R-HSA-74182	9.772573e-01	0.010	0	0
Biosynthesis of maresins	R-HSA-9018682	9.772573e-01	0.010	0	0
Neuronal System	R-HSA-112316	9.773141e-01	0.010	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.783658e-01	0.009	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	9.783658e-01	0.009	0	0
Collagen chain trimerization	R-HSA-8948216	9.783658e-01	0.009	0	0
Plasma lipoprotein assembly	R-HSA-8963898	9.800415e-01	0.009	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	9.800415e-01	0.009	0	0
tRNA processing in the mitochondrion	R-HSA-6785470	9.806481e-01	0.008	0	0
Elastic fibre formation	R-HSA-1566948	9.806481e-01	0.008	0	0
Ribosome-associated quality control	R-HSA-9948299	9.810997e-01	0.008	0	0
Collagen formation	R-HSA-1474290	9.816565e-01	0.008	0	0
SLC transporter disorders	R-HSA-5619102	9.816951e-01	0.008	0	0
Tight junction interactions	R-HSA-420029	9.824849e-01	0.008	0	0
Hyaluronan degradation	R-HSA-2160916	9.824849e-01	0.008	0	0
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.824849e-01	0.008	0	0
Laminin interactions	R-HSA-3000157	9.824849e-01	0.008	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.826959e-01	0.008	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.826959e-01	0.008	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	9.843418e-01	0.007	0	0
Glycogen metabolism	R-HSA-8982491	9.845325e-01	0.007	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.845325e-01	0.007	0	0
Sphingolipid catabolism	R-HSA-9845614	9.846294e-01	0.007	0	0
Diseases of branched-chain amino acid catabolism	R-HSA-9865118	9.846294e-01	0.007	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	9.846294e-01	0.007	0	0
Formation of the cornified envelope	R-HSA-6809371	9.848407e-01	0.007	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.855426e-01	0.006	0	0
Translation of Structural Proteins	R-HSA-9694635	9.858668e-01	0.006	0	0
Aflatoxin activation and detoxification	R-HSA-5423646	9.861790e-01	0.006	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.861790e-01	0.006	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.861790e-01	0.006	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.862899e-01	0.006	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	9.865114e-01	0.006	0	0
Phosphorylation of CD3 and TCR zeta chains	R-HSA-202427	9.865114e-01	0.006	0	0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	R-HSA-83936	9.865114e-01	0.006	0	0
Triglyceride biosynthesis	R-HSA-75109	9.865114e-01	0.006	0	0
Synthesis of PE	R-HSA-1483213	9.865114e-01	0.006	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	9.865114e-01	0.006	0	0
Integrin cell surface interactions	R-HSA-216083	9.870685e-01	0.006	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.876542e-01	0.005	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.876542e-01	0.005	0	0
Translation of Structural Proteins	R-HSA-9683701	9.876542e-01	0.005	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.877732e-01	0.005	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	9.881631e-01	0.005	0	0
Pyroptosis	R-HSA-5620971	9.881631e-01	0.005	0	0
Prednisone ADME	R-HSA-9757110	9.881631e-01	0.005	0	0
Paracetamol ADME	R-HSA-9753281	9.884601e-01	0.005	0	0
PPARA activates gene expression	R-HSA-1989781	9.888516e-01	0.005	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.889755e-01	0.005	0	0
Innate Immune System	R-HSA-168249	9.889912e-01	0.005	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.890640e-01	0.005	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.890640e-01	0.005	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.895366e-01	0.005	0	0
Ion homeostasis	R-HSA-5578775	9.895892e-01	0.005	0	0
Platelet calcium homeostasis	R-HSA-418360	9.896126e-01	0.005	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.901197e-01	0.004	0	0
Pyrimidine catabolism	R-HSA-73621	9.901585e-01	0.004	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	9.902493e-01	0.004	0	0
Dectin-2 family	R-HSA-5621480	9.906114e-01	0.004	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.913076e-01	0.004	0	0
Retinoid metabolism and transport	R-HSA-975634	9.918049e-01	0.004	0	0
Viral mRNA Translation	R-HSA-192823	9.918242e-01	0.004	0	0
Budding and maturation of HIV virion	R-HSA-162588	9.920010e-01	0.003	0	0
Synthesis of glycosylphosphatidylinositol (GPI)	R-HSA-162710	9.920010e-01	0.003	0	0
Diseases associated with glycosaminoglycan metabolism	R-HSA-3560782	9.921641e-01	0.003	0	0
Peroxisomal protein import	R-HSA-9033241	9.923731e-01	0.003	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.926919e-01	0.003	0	0
G alpha (s) signalling events	R-HSA-418555	9.929662e-01	0.003	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	9.929662e-01	0.003	0	0
HS-GAG degradation	R-HSA-2024096	9.929807e-01	0.003	0	0
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	9.930110e-01	0.003	0	0
RAB geranylgeranylation	R-HSA-8873719	9.931294e-01	0.003	0	0
Neddylation	R-HSA-8951664	9.934614e-01	0.003	0	0
Collagen degradation	R-HSA-1442490	9.938130e-01	0.003	0	0
Recycling of bile acids and salts	R-HSA-159418	9.938405e-01	0.003	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.942943e-01	0.002	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	9.944445e-01	0.002	0	0
CS/DS degradation	R-HSA-2024101	9.945950e-01	0.002	0	0
Pyruvate metabolism	R-HSA-70268	9.948001e-01	0.002	0	0
G alpha (q) signalling events	R-HSA-416476	9.948547e-01	0.002	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.950588e-01	0.002	0	0
Stimuli-sensing channels	R-HSA-2672351	9.950588e-01	0.002	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.952571e-01	0.002	0	0
Hyaluronan metabolism	R-HSA-2142845	9.952571e-01	0.002	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.952571e-01	0.002	0	0
Phosphate bond hydrolysis by NUDT proteins	R-HSA-2393930	9.952571e-01	0.002	0	0
ER-Phagosome pathway	R-HSA-1236974	9.956858e-01	0.002	0	0
Ion channel transport	R-HSA-983712	9.958479e-01	0.002	0	0
ABC transporter disorders	R-HSA-5619084	9.958748e-01	0.002	0	0
The phototransduction cascade	R-HSA-2514856	9.960703e-01	0.002	0	0
HS-GAG biosynthesis	R-HSA-2022928	9.963480e-01	0.002	0	0
Glycosphingolipid transport	R-HSA-9845576	9.963480e-01	0.002	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.963480e-01	0.002	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.965003e-01	0.002	0	0
NCAM1 interactions	R-HSA-419037	9.967954e-01	0.001	0	0
Metabolism of folate and pterines	R-HSA-196757	9.967954e-01	0.001	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.970328e-01	0.001	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.970328e-01	0.001	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.970426e-01	0.001	0	0
Purine salvage	R-HSA-74217	9.971881e-01	0.001	0	0
FCGR activation	R-HSA-2029481	9.973112e-01	0.001	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.975150e-01	0.001	0	0
Pentose phosphate pathway	R-HSA-71336	9.975326e-01	0.001	0	0
Maturation of TCA enzymes and regulation of TCA cycle	R-HSA-9854311	9.978350e-01	0.001	0	0
Tryptophan catabolism	R-HSA-71240	9.978350e-01	0.001	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.978350e-01	0.001	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.979831e-01	0.001	0	0
Peptide hormone metabolism	R-HSA-2980736	9.980990e-01	0.001	0	0
Purine ribonucleoside monophosphate biosynthesis	R-HSA-73817	9.981003e-01	0.001	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.981548e-01	0.001	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.983331e-01	0.001	0	0
Developmental Cell Lineages	R-HSA-9734767	9.983613e-01	0.001	0	0
Citric acid cycle (TCA cycle)	R-HSA-71403	9.986184e-01	0.001	0	0
Glutathione conjugation	R-HSA-156590	9.986257e-01	0.001	0	0
Metabolism of polyamines	R-HSA-351202	9.986257e-01	0.001	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.987677e-01	0.001	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.987763e-01	0.001	0	0
Endogenous sterols	R-HSA-211976	9.987783e-01	0.001	0	0
Nucleotide salvage	R-HSA-8956321	9.987783e-01	0.001	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.987933e-01	0.001	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.987973e-01	0.001	0	0
Methylation	R-HSA-156581	9.988740e-01	0.000	0	0
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	9.988740e-01	0.000	0	0
Neurotransmitter release cycle	R-HSA-112310	9.988946e-01	0.000	0	0
Interleukin-10 signaling	R-HSA-6783783	9.990048e-01	0.000	0	0
Degradation of cysteine and homocysteine	R-HSA-1614558	9.990120e-01	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	9.990159e-01	0.000	0	0
Xenobiotics	R-HSA-211981	9.991427e-01	0.000	0	0
Synthesis of PC	R-HSA-1483191	9.992394e-01	0.000	0	0
Metabolism of proteins	R-HSA-392499	9.992943e-01	0.000	0	0
Gluconeogenesis	R-HSA-70263	9.993327e-01	0.000	0	0
Metabolism of steroid hormones	R-HSA-196071	9.993993e-01	0.000	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.994145e-01	0.000	0	0
Glyoxylate metabolism and glycine degradation	R-HSA-389661	9.994145e-01	0.000	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.994266e-01	0.000	0	0
Translation	R-HSA-72766	9.994847e-01	0.000	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.994863e-01	0.000	0	0
Complex IV assembly	R-HSA-9864848	9.995493e-01	0.000	0	0
Cytosolic sulfonation of small molecules	R-HSA-156584	9.995493e-01	0.000	0	0
Branched-chain amino acid catabolism	R-HSA-70895	9.995493e-01	0.000	0	0
Fatty acyl-CoA biosynthesis	R-HSA-75105	9.995797e-01	0.000	0	0
Metabolism of cofactors	R-HSA-8978934	9.996269e-01	0.000	0	0
Nucleotide biosynthesis	R-HSA-8956320	9.996531e-01	0.000	0	0
Classical antibody-mediated complement activation	R-HSA-173623	9.997062e-01	0.000	0	0
Chondroitin sulfate/dermatan sulfate metabolism	R-HSA-1793185	9.997329e-01	0.000	0	0
Infectious disease	R-HSA-5663205	9.997510e-01	0.000	0	0
Iron uptake and transport	R-HSA-917937	9.997689e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.997711e-01	0.000	0	0
Synthesis of PA	R-HSA-1483166	9.997944e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.997951e-01	0.000	0	0
Phospholipid metabolism	R-HSA-1483257	9.998116e-01	0.000	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.998333e-01	0.000	0	0
Cholesterol biosynthesis	R-HSA-191273	9.998388e-01	0.000	0	0
Heparan sulfate/heparin (HS-GAG) metabolism	R-HSA-1638091	9.998418e-01	0.000	0	0
Protein localization	R-HSA-9609507	9.998480e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.998651e-01	0.000	0	0
Cardiac conduction	R-HSA-5576891	9.998705e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.998935e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999050e-01	0.000	0	0
Complex I biogenesis	R-HSA-6799198	9.999063e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999243e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999270e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999357e-01	0.000	0	0
Nicotinate metabolism	R-HSA-196807	9.999445e-01	0.000	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.999445e-01	0.000	0	0
Disease	R-HSA-1643685	9.999614e-01	0.000	1	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999666e-01	0.000	0	0
ECM proteoglycans	R-HSA-3000178	9.999671e-01	0.000	0	0
Purine catabolism	R-HSA-74259	9.999712e-01	0.000	0	0
Creation of C4 and C2 activators	R-HSA-166786	9.999731e-01	0.000	0	0
Aspirin ADME	R-HSA-9749641	9.999747e-01	0.000	0	0
Diseases of carbohydrate metabolism	R-HSA-5663084	9.999747e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999752e-01	0.000	0	0
Transport of vitamins, nucleosides, and related molecules	R-HSA-425397	9.999778e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999790e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999809e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.999846e-01	0.000	0	0
Potassium Channels	R-HSA-1296071	9.999874e-01	0.000	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.999885e-01	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	9.999888e-01	0.000	0	0
Initial triggering of complement	R-HSA-166663	9.999905e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999906e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.999911e-01	0.000	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.999913e-01	0.000	0	0
Complement cascade	R-HSA-166658	9.999943e-01	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	9.999945e-01	0.000	0	0
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	9.999958e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.999960e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999963e-01	0.000	0	0
GPCR downstream signalling	R-HSA-388396	9.999975e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999975e-01	0.000	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.999980e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999982e-01	0.000	0	0
Nucleotide catabolism	R-HSA-8956319	9.999987e-01	0.000	0	0
Mitochondrial Fatty Acid Beta-Oxidation	R-HSA-77289	9.999989e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999997e-01	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	9.999997e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.999998e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999999e-01	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	9.999999e-01	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	9.999999e-01	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Metabolism of steroids	R-HSA-8957322	1.000000e+00	0.000	0	0
Sensory perception of sweet, bitter, and umami (glutamate) taste	R-HSA-9717207	1.000000e+00	0.000	0	0
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
Sensory perception of taste	R-HSA-9717189	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000	0	0

Top15 pathways (red highlights are reference pathways)

Compared with reference pathways

Motif of predicted substrate sequence

Reactome pathways of predicted substrates

Download

name	reactome_id	p	-log10p	ref_path	ref_path_lowest
TP53 Regulates Transcription of DNA Repair Genes	R-HSA-6796648	5.241363e-13	12.281	1	1
DNA Double-Strand Break Repair	R-HSA-5693532	6.340595e-12	11.198	1	0
Diseases of DNA Double-Strand Break Repair	R-HSA-9675136	8.790102e-11	10.056	1	0
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	R-HSA-9701190	8.790102e-11	10.056	1	0
Homologous DNA Pairing and Strand Exchange	R-HSA-5693579	9.442225e-11	10.025	1	1
Transcriptional Regulation by TP53	R-HSA-3700989	7.147372e-11	10.146	1	0
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-5693616	1.392698e-10	9.856	1	1
Regulation of TP53 Activity through Phosphorylation	R-HSA-6804756	1.372652e-10	9.862	1	1
Impaired BRCA2 binding to RAD51	R-HSA-9709570	1.738760e-10	9.760	1	1
HDR through Single Strand Annealing (SSA)	R-HSA-5685938	2.017749e-10	9.695	1	1
Regulation of TP53 Activity	R-HSA-5633007	6.729874e-10	9.172	1	0
Diseases of DNA repair	R-HSA-9675135	6.808748e-10	9.167	1	0
DNA Repair	R-HSA-73894	1.179056e-09	8.928	1	0
Cell Cycle	R-HSA-1640170	1.352953e-09	8.869	1	0
HDR through Homologous Recombination (HRR)	R-HSA-5685942	1.760829e-09	8.754	1	1
Impaired BRCA2 binding to PALB2	R-HSA-9709603	5.871928e-09	8.231	1	1
Homology Directed Repair	R-HSA-5693538	5.685629e-09	8.245	1	0
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	R-HSA-5693567	5.204767e-09	8.284	1	0
Defective homologous recombination repair (HRR) due to PALB2 loss of function	R-HSA-9701193	1.028571e-08	7.988	1	0
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	R-HSA-9704646	1.028571e-08	7.988	1	1
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	R-HSA-9701192	1.028571e-08	7.988	1	1
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	R-HSA-9704331	1.028571e-08	7.988	1	1
Resolution of D-loop Structures through Holliday Junction Intermediates	R-HSA-5693568	3.328039e-08	7.478	1	1
G2/M DNA damage checkpoint	R-HSA-69473	4.378906e-08	7.359	1	1
Resolution of D-Loop Structures	R-HSA-5693537	4.905057e-08	7.309	1	0
Gene expression (Transcription)	R-HSA-74160	1.207246e-07	6.918	1	0
Cell Cycle Checkpoints	R-HSA-69620	1.349441e-07	6.870	1	0
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	R-HSA-5693554	1.845221e-07	6.734	1	1
RNA Polymerase II Transcription	R-HSA-73857	2.027768e-07	6.693	1	0
Processing of DNA double-strand break ends	R-HSA-5693607	2.244126e-07	6.649	1	1
Expression of BMAL (ARNTL), CLOCK, and NPAS2	R-HSA-9931509	3.993965e-07	6.399	0	0
G2/M Checkpoints	R-HSA-69481	7.903376e-07	6.102	1	0
Heme signaling	R-HSA-9707616	1.276116e-06	5.894	0	0
Nonhomologous End-Joining (NHEJ)	R-HSA-5693571	1.810688e-06	5.742	1	1
Generic Transcription Pathway	R-HSA-212436	1.410451e-05	4.851	1	0
Formation of WDR5-containing histone-modifying complexes	R-HSA-9772755	3.371462e-05	4.472	0	0
Diseases of signal transduction by growth factor receptors and second messengers	R-HSA-5663202	3.453772e-05	4.462	0	0
Cell Cycle, Mitotic	R-HSA-69278	6.667094e-05	4.176	0	0
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	R-HSA-9931510	1.276448e-04	3.894	0	0
ZBP1(DAI) mediated induction of type I IFNs	R-HSA-1606322	1.427715e-04	3.845	0	0
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	1.779547e-04	3.750	0	0
Activation of ATR in response to replication stress	R-HSA-176187	2.126735e-04	3.672	0	0
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	2.892132e-04	3.539	0	0
Circadian clock	R-HSA-9909396	3.199333e-04	3.495	0	0
Regulation of NFE2L2 gene expression	R-HSA-9818749	3.431025e-04	3.465	0	0
RNA Polymerase II Pre-transcription Events	R-HSA-674695	3.345055e-04	3.476	0	0
Interleukin-37 signaling	R-HSA-9008059	3.662994e-04	3.436	0	0
Deubiquitination	R-HSA-5688426	4.034096e-04	3.394	0	0
Chromatin organization	R-HSA-4839726	4.566627e-04	3.340	0	0
Chromatin modifying enzymes	R-HSA-3247509	4.633567e-04	3.334	0	0
YAP1- and WWTR1 (TAZ)-stimulated gene expression	R-HSA-2032785	5.595050e-04	3.252	0	0
FOXO-mediated transcription of cell death genes	R-HSA-9614657	6.383767e-04	3.195	0	0
Meiosis	R-HSA-1500620	6.434072e-04	3.192	1	0
RIP-mediated NFkB activation via ZBP1	R-HSA-1810476	7.907936e-04	3.102	0	0
Transcriptional activation of mitochondrial biogenesis	R-HSA-2151201	9.037233e-04	3.044	0	0
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	R-HSA-210744	1.093298e-03	2.961	0	0
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	R-HSA-9933387	1.262059e-03	2.899	0	0
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	R-HSA-5693565	1.545771e-03	2.811	1	1
Nuclear Events (kinase and transcription factor activation)	R-HSA-198725	1.564787e-03	2.806	0	0
RUNX2 regulates bone development	R-HSA-8941326	1.652162e-03	2.782	0	0
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	R-HSA-5368598	1.753387e-03	2.756	0	0
Transcriptional regulation by RUNX3	R-HSA-8878159	1.764366e-03	2.753	0	0
NGF-stimulated transcription	R-HSA-9031628	1.959228e-03	2.708	0	0
Cellular responses to stress	R-HSA-2262752	1.951493e-03	2.710	1	0
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	1.991462e-03	2.701	0	0
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	2.189784e-03	2.660	0	0
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	2.533776e-03	2.596	0	0
RUNX2 regulates osteoblast differentiation	R-HSA-8940973	2.695742e-03	2.569	0	0
Signaling by NOTCH1	R-HSA-1980143	2.614708e-03	2.583	0	0
Regulation of TP53 Expression and Degradation	R-HSA-6806003	2.841556e-03	2.546	1	0
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	3.047357e-03	2.516	0	0
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	R-HSA-5603027	3.604774e-03	2.443	0	0
IKBKB deficiency causes SCID	R-HSA-5602636	3.604774e-03	2.443	0	0
IRF3-mediated induction of type I IFN	R-HSA-3270619	3.442087e-03	2.463	0	0
Formation of RNA Pol II elongation complex	R-HSA-112382	3.593595e-03	2.444	0	0
Mitotic Prometaphase	R-HSA-68877	3.530364e-03	2.452	0	0
STING mediated induction of host immune responses	R-HSA-1834941	3.331214e-03	2.477	0	0
MyD88-independent TLR4 cascade	R-HSA-166166	3.617445e-03	2.442	0	0
TRIF (TICAM1)-mediated TLR4 signaling	R-HSA-937061	3.617445e-03	2.442	0	0
Cohesin Loading onto Chromatin	R-HSA-2470946	3.661745e-03	2.436	0	0
NOTCH3 Intracellular Domain Regulates Transcription	R-HSA-9013508	4.007134e-03	2.397	0	0
Gastrulation	R-HSA-9758941	3.806786e-03	2.419	0	0
Regulation of PD-L1(CD274) transcription	R-HSA-9909649	4.021369e-03	2.396	0	0
RNA Polymerase II Transcription Elongation	R-HSA-75955	4.140892e-03	2.383	0	0
Signaling by NOTCH1 in Cancer	R-HSA-2644603	4.387227e-03	2.358	0	0
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	4.387227e-03	2.358	0	0
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	4.387227e-03	2.358	0	0
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	4.387227e-03	2.358	0	0
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	4.387227e-03	2.358	0	0
DNA Double Strand Break Response	R-HSA-5693606	4.554310e-03	2.342	1	0
Mitotic Telophase/Cytokinesis	R-HSA-68884	4.455310e-03	2.351	0	0
Cellular Senescence	R-HSA-2559583	4.231478e-03	2.374	1	0
TGFBR3 expression	R-HSA-9839394	4.669435e-03	2.331	0	0
Regulation of TP53 Degradation	R-HSA-6804757	4.800081e-03	2.319	1	1
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	R-HSA-141405	5.857335e-03	2.232	0	0
Inactivation of APC/C via direct inhibition of the APC/C complex	R-HSA-141430	5.857335e-03	2.232	0	0
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	5.760244e-03	2.240	0	0
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex	R-HSA-9931521	5.857335e-03	2.232	0	0
RUNX3 regulates NOTCH signaling	R-HSA-8941856	6.040274e-03	2.219	0	0
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	6.402429e-03	2.194	0	0
Loss of Nlp from mitotic centrosomes	R-HSA-380259	6.402429e-03	2.194	0	0
Epigenetic regulation of gene expression	R-HSA-212165	6.543050e-03	2.184	0	0
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	6.497635e-03	2.187	0	0
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	R-HSA-8939243	6.865580e-03	2.163	0	0
Cardiogenesis	R-HSA-9733709	6.865580e-03	2.163	0	0
M Phase	R-HSA-68886	7.031600e-03	2.153	0	0
Transcriptional Regulation by MECP2	R-HSA-8986944	7.085101e-03	2.150	0	0
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	7.456544e-03	2.127	0	0
Meiotic recombination	R-HSA-912446	7.705655e-03	2.113	1	1
Signaling by TGF-beta Receptor Complex	R-HSA-170834	7.611427e-03	2.119	0	0
Estrogen-dependent gene expression	R-HSA-9018519	7.654724e-03	2.116	0	0
Ub-specific processing proteases	R-HSA-5689880	7.772980e-03	2.109	0	0
Cellular responses to stimuli	R-HSA-8953897	7.901259e-03	2.102	1	0
NFE2L2 regulating tumorigenic genes	R-HSA-9818030	8.000552e-03	2.097	0	0
HDR through MMEJ (alt-NHEJ)	R-HSA-5685939	8.000552e-03	2.097	0	0
Reproduction	R-HSA-1474165	8.045059e-03	2.094	1	0
Notch-HLH transcription pathway	R-HSA-350054	8.119366e-03	2.090	0	0
IkBA variant leads to EDA-ID	R-HSA-5603029	9.091287e-03	2.041	0	0
AURKA Activation by TPX2	R-HSA-8854518	9.101734e-03	2.041	0	0
MAPK targets/ Nuclear events mediated by MAP kinases	R-HSA-450282	9.853411e-03	2.006	0	0
HATs acetylate histones	R-HSA-3214847	9.157291e-03	2.038	0	0
Epigenetic regulation by WDR5-containing histone modifying complexes	R-HSA-9917777	9.934855e-03	2.003	0	0
Regulation of PTEN gene transcription	R-HSA-8943724	1.013760e-02	1.994	0	0
Formation of the canonical BAF (cBAF) complex	R-HSA-9933937	1.038092e-02	1.984	0	0
Establishment of Sister Chromatid Cohesion	R-HSA-2468052	1.067219e-02	1.972	0	0
Cellular response to heat stress	R-HSA-3371556	1.126659e-02	1.948	1	0
Oncogene Induced Senescence	R-HSA-2559585	1.109618e-02	1.955	0	0
MAP kinase activation	R-HSA-450294	1.137678e-02	1.944	0	0
Positive Regulation of CDH1 Gene Transcription	R-HSA-9764790	1.067219e-02	1.972	0	0
Signaling by NTRK1 (TRKA)	R-HSA-187037	1.155647e-02	1.937	0	0
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	1.184175e-02	1.927	0	0
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	1.290954e-02	1.889	0	0
STAT6-mediated induction of chemokines	R-HSA-3249367	1.441005e-02	1.841	0	0
RUNX3 regulates YAP1-mediated transcription	R-HSA-8951671	1.347667e-02	1.870	0	0
Formation of the embryonic stem cell BAF (esBAF) complex	R-HSA-9933946	1.322461e-02	1.879	0	0
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	1.418509e-02	1.848	0	0
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	R-HSA-9934037	1.418509e-02	1.848	0	0
NRAGE signals death through JNK	R-HSA-193648	1.424370e-02	1.846	0	0
Mitochondrial biogenesis	R-HSA-1592230	1.499516e-02	1.824	0	0
Alternative Lengthening of Telomeres (ALT)	R-HSA-9006821	1.754954e-02	1.756	0	0
Defective Inhibition of DNA Recombination at Telomere	R-HSA-9670621	1.754954e-02	1.756	0	0
Diseases of Telomere Maintenance	R-HSA-9673013	1.754954e-02	1.756	0	0
Defective DNA double strand break response due to BARD1 loss of function	R-HSA-9699150	1.754954e-02	1.756	0	0
Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	R-HSA-9670615	1.754954e-02	1.756	0	0
Defective Mismatch Repair Associated With MLH1	R-HSA-5545483	1.754954e-02	1.756	0	0
Defective Mismatch Repair Associated With PMS2	R-HSA-5632987	1.754954e-02	1.756	0	0
Defective DNA double strand break response due to BRCA1 loss of function	R-HSA-9663199	1.754954e-02	1.756	0	0
Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	R-HSA-9670613	1.754954e-02	1.756	0	0
NOTCH4 Intracellular Domain Regulates Transcription	R-HSA-9013695	1.717003e-02	1.765	0	0
APC-Cdc20 mediated degradation of Nek2A	R-HSA-179409	1.717003e-02	1.765	0	0
G0 and Early G1	R-HSA-1538133	1.596159e-02	1.797	0	0
Diseases of mitotic cell cycle	R-HSA-9675126	1.596159e-02	1.797	0	0
MyD88 cascade initiated on plasma membrane	R-HSA-975871	1.611070e-02	1.793	0	0
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	1.611070e-02	1.793	0	0
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	1.611070e-02	1.793	0	0
Death Receptor Signaling	R-HSA-73887	1.697399e-02	1.770	0	0
Zygotic genome activation (ZGA)	R-HSA-9819196	1.717003e-02	1.765	0	0
RNA polymerase II transcribes snRNA genes	R-HSA-6807505	1.758278e-02	1.755	0	0
ATF6 (ATF6-alpha) activates chaperone genes	R-HSA-381183	1.859565e-02	1.731	0	0
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	R-HSA-9931512	1.859565e-02	1.731	0	0
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	1.889870e-02	1.724	0	0
Role of ABL in ROBO-SLIT signaling	R-HSA-428890	1.901481e-02	1.721	0	0
MECP2 regulates transcription factors	R-HSA-9022707	1.901481e-02	1.721	0	0
Signaling by NTRKs	R-HSA-166520	1.931350e-02	1.714	0	0
Signaling by ALK fusions and activated point mutants	R-HSA-9725370	1.950372e-02	1.710	0	0
Signaling by ALK in cancer	R-HSA-9700206	1.950372e-02	1.710	0	0
Processive synthesis on the C-strand of the telomere	R-HSA-174414	1.976739e-02	1.704	0	0
Fanconi Anemia Pathway	R-HSA-6783310	1.994791e-02	1.700	0	0
Recruitment of NuMA to mitotic centrosomes	R-HSA-380320	2.094016e-02	1.679	0	0
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	2.106230e-02	1.676	0	0
MyD88 dependent cascade initiated on endosome	R-HSA-975155	2.271516e-02	1.644	0	0
Centrosome maturation	R-HSA-380287	2.280626e-02	1.642	0	0
NFE2L2 regulating ER-stress associated genes	R-HSA-9818035	2.315211e-02	1.635	0	0
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	R-HSA-2644607	2.315211e-02	1.635	0	0
FBXW7 Mutants and NOTCH1 in Cancer	R-HSA-2644605	2.315211e-02	1.635	0	0
Transcription of the HIV genome	R-HSA-167172	2.364560e-02	1.626	0	0
NOTCH2 intracellular domain regulates transcription	R-HSA-2197563	2.370966e-02	1.625	0	0
IRAK1 recruits IKK complex	R-HSA-937039	2.370966e-02	1.625	0	0
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	R-HSA-975144	2.370966e-02	1.625	0	0
Regulation of FOXO transcriptional activity by acetylation	R-HSA-9617629	2.370966e-02	1.625	0	0
Signaling by LTK	R-HSA-9842663	2.370966e-02	1.625	0	0
Signaling by TGFB family members	R-HSA-9006936	2.470304e-02	1.607	0	0
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	2.492921e-02	1.603	0	0
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	2.492921e-02	1.603	0	0
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	2.544190e-02	1.594	0	0
ATF6 (ATF6-alpha) activates chaperones	R-HSA-381033	2.965171e-02	1.528	0	0
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	2.965171e-02	1.528	0	0
Regulation of TP53 Activity through Methylation	R-HSA-6804760	3.000253e-02	1.523	1	1
PPARA activates gene expression	R-HSA-1989781	2.978981e-02	1.526	0	0
Formation of axial mesoderm	R-HSA-9796292	2.965171e-02	1.528	0	0
Interleukin-17 signaling	R-HSA-448424	2.850589e-02	1.545	0	0
Mismatch Repair	R-HSA-5358508	3.000253e-02	1.523	0	0
Organelle biogenesis and maintenance	R-HSA-1852241	2.766051e-02	1.558	0	0
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	3.033678e-02	1.518	0	0
Activation of the pre-replicative complex	R-HSA-68962	3.078912e-02	1.512	0	0
Mitotic G2-G2/M phases	R-HSA-453274	3.151700e-02	1.501	0	0
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	3.191512e-02	1.496	0	0
Regulation of lipid metabolism by PPARalpha	R-HSA-400206	3.346173e-02	1.475	0	0
AKT phosphorylates targets in the nucleus	R-HSA-198693	3.382070e-02	1.471	0	0
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	R-HSA-3134963	3.419714e-02	1.466	0	0
RUNX2 regulates chondrocyte maturation	R-HSA-8941284	3.419714e-02	1.466	0	0
NFE2L2 regulating inflammation associated genes	R-HSA-9818026	3.419714e-02	1.466	0	0
Mitotic Spindle Checkpoint	R-HSA-69618	3.441200e-02	1.463	0	0
Formation of the polybromo-BAF (pBAF) complex	R-HSA-9933939	3.645515e-02	1.438	0	0
SMAD4 MH2 Domain Mutants in Cancer	R-HSA-3311021	3.699223e-02	1.432	0	0
Loss of Function of SMAD4 in Cancer	R-HSA-3304347	3.699223e-02	1.432	0	0
SMAD2/3 MH2 Domain Mutants in Cancer	R-HSA-3315487	3.699223e-02	1.432	0	0
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	3.711614e-02	1.430	0	0
TICAM1, RIP1-mediated IKK complex recruitment	R-HSA-168927	4.414369e-02	1.355	0	0
Transcription of E2F targets under negative control by DREAM complex	R-HSA-1362277	4.206767e-02	1.376	0	0
SWI/SNF chromatin remodelers	R-HSA-9932451	3.883083e-02	1.411	0	0
ATP-dependent chromatin remodelers	R-HSA-9932444	3.883083e-02	1.411	0	0
Sema4D in semaphorin signaling	R-HSA-400685	3.883083e-02	1.411	0	0
Myogenesis	R-HSA-525793	4.465524e-02	1.350	0	0
Adipogenesis	R-HSA-9843745	4.432334e-02	1.353	0	0
Regulation of beta-cell development	R-HSA-186712	4.086596e-02	1.389	0	0
Formation of intermediate mesoderm	R-HSA-9761174	4.316396e-02	1.365	0	0
E3 ubiquitin ligases ubiquitinate target proteins	R-HSA-8866654	4.257425e-02	1.371	0	0
Transcriptional Regulation by E2F6	R-HSA-8953750	4.507169e-02	1.346	0	0
Formation of the anterior neural plate	R-HSA-9823739	4.414369e-02	1.355	0	0
Apoptotic cleavage of cellular proteins	R-HSA-111465	4.011919e-02	1.397	0	0
RUNX3 regulates CDKN1A transcription	R-HSA-8941855	4.750121e-02	1.323	0	0
Epithelial-Mesenchymal Transition (EMT) during gastrulation	R-HSA-9758919	4.750121e-02	1.323	0	0
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	4.750121e-02	1.323	0	0
SLC15A4:TASL-dependent IRF5 activation	R-HSA-9860276	4.750121e-02	1.323	0	0
Signaling by TGFBR3	R-HSA-9839373	4.873824e-02	1.312	0	0
Regulation of TNFR1 signaling	R-HSA-5357905	4.873824e-02	1.312	0	0
SHC-mediated cascade:FGFR2	R-HSA-5654699	5.101300e-02	1.292	0	0
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	R-HSA-6803204	5.101300e-02	1.292	1	1
Disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	5.101300e-02	1.292	0	0
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	R-HSA-166058	5.109666e-02	1.292	0	0
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	5.109666e-02	1.292	0	0
Drug resistance in ERBB2 KD mutants	R-HSA-9665230	6.164521e-02	1.210	0	0
ATF6B (ATF6-beta) activates chaperones	R-HSA-8874177	6.164521e-02	1.210	0	0
Regulation of TP53 Expression	R-HSA-6804754	6.164521e-02	1.210	0	0
Drug-mediated inhibition of ERBB2 signaling	R-HSA-9652282	6.164521e-02	1.210	0	0
Resistance of ERBB2 KD mutants to neratinib	R-HSA-9665246	6.164521e-02	1.210	0	0
Resistance of ERBB2 KD mutants to osimertinib	R-HSA-9665247	6.164521e-02	1.210	0	0
Resistance of ERBB2 KD mutants to AEE788	R-HSA-9665250	6.164521e-02	1.210	0	0
Resistance of ERBB2 KD mutants to sapitinib	R-HSA-9665244	6.164521e-02	1.210	0	0
Drug resistance in ERBB2 TMD/JMD mutants	R-HSA-9665737	6.164521e-02	1.210	0	0
Resistance of ERBB2 KD mutants to tesevatinib	R-HSA-9665245	6.164521e-02	1.210	0	0
Resistance of ERBB2 KD mutants to lapatinib	R-HSA-9665251	6.164521e-02	1.210	0	0
Resistance of ERBB2 KD mutants to trastuzumab	R-HSA-9665233	6.164521e-02	1.210	0	0
Resistance of ERBB2 KD mutants to afatinib	R-HSA-9665249	6.164521e-02	1.210	0	0
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	5.381353e-02	1.269	0	0
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	R-HSA-1362300	5.273147e-02	1.278	0	0
Negative regulation of FGFR2 signaling	R-HSA-5654727	5.735266e-02	1.241	0	0
Dual Incision in GG-NER	R-HSA-5696400	5.735266e-02	1.241	0	0
Resolution of Sister Chromatid Cohesion	R-HSA-2500257	5.757202e-02	1.240	0	0
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	5.328999e-02	1.273	1	1
Regulation of NF-kappa B signaling	R-HSA-9758274	5.273147e-02	1.278	0	0
FOXO-mediated transcription of cell cycle genes	R-HSA-9617828	5.680575e-02	1.246	0	0
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.101633e-02	1.215	0	0
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.101633e-02	1.215	0	0
TNF signaling	R-HSA-75893	6.138914e-02	1.212	0	0
Signaling by NOTCH3	R-HSA-9012852	5.624968e-02	1.250	0	0
p75 NTR receptor-mediated signalling	R-HSA-193704	5.572202e-02	1.254	0	0
Interleukin-1 family signaling	R-HSA-446652	6.285250e-02	1.202	0	0
DNA Damage Bypass	R-HSA-73893	6.482740e-02	1.188	0	0
G2/M Transition	R-HSA-69275	6.572375e-02	1.182	0	0
TICAM1-dependent activation of IRF3/IRF7	R-HSA-9013973	6.575358e-02	1.182	0	0
Regulation of gene expression by Hypoxia-inducible Factor	R-HSA-1234158	6.575358e-02	1.182	0	0
Signaling by AMER1 mutants	R-HSA-4839748	6.575358e-02	1.182	0	0
Signaling by AXIN mutants	R-HSA-4839735	6.575358e-02	1.182	0	0
Sensing of DNA Double Strand Breaks	R-HSA-5693548	6.575358e-02	1.182	1	1
ESR-mediated signaling	R-HSA-8939211	6.586704e-02	1.181	0	0
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	6.749722e-02	1.171	1	1
HSF1 activation	R-HSA-3371511	7.109992e-02	1.148	0	0
Dual incision in TC-NER	R-HSA-6782135	7.256652e-02	1.139	0	0
Signaling by Hippo	R-HSA-2028269	7.261456e-02	1.139	0	0
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	R-HSA-176407	7.261456e-02	1.139	0	0
Modulation of host responses by IFN-stimulated genes	R-HSA-9909505	7.261456e-02	1.139	0	0
Unfolded Protein Response (UPR)	R-HSA-381119	7.287488e-02	1.137	0	0
Aberrant regulation of mitotic cell cycle due to RB1 defects	R-HSA-9687139	7.336568e-02	1.135	0	0
Signaling by FGFR in disease	R-HSA-1226099	7.385246e-02	1.132	0	0
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	R-HSA-9634638	7.428390e-02	1.129	0	0
Metabolism of non-coding RNA	R-HSA-194441	7.861053e-02	1.105	0	0
snRNP Assembly	R-HSA-191859	7.861053e-02	1.105	0	0
Constitutive Signaling by Overexpressed ERBB2	R-HSA-9634285	7.895051e-02	1.103	0	0
Protein ubiquitination	R-HSA-8852135	7.928587e-02	1.101	0	0
Deletions in the AXIN1 gene destabilize the destruction complex	R-HSA-5467345	9.526091e-02	1.021	0	0
Loss of function of TP53 in cancer due to loss of tetramerization ability	R-HSA-9723905	9.526091e-02	1.021	0	0
APC truncation mutants are not K63 polyubiquitinated	R-HSA-5467333	9.526091e-02	1.021	0	0
Loss of Function of TP53 in Cancer	R-HSA-9723907	9.526091e-02	1.021	0	0
Deletions in the AMER1 gene destabilize the destruction complex	R-HSA-5467343	9.526091e-02	1.021	0	0
Signaling by FGFR2 amplification mutants	R-HSA-2023837	9.034059e-02	1.044	0	0
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	R-HSA-5660862	9.034059e-02	1.044	0	0
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	R-HSA-2892245	8.043854e-02	1.095	0	0
Regulation of PTEN localization	R-HSA-8948747	8.043854e-02	1.095	0	0
Binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	8.043854e-02	1.095	0	0
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	R-HSA-9828211	9.975577e-02	1.001	0	0
Formation of the non-canonical BAF (ncBAF) complex	R-HSA-9933947	9.335535e-02	1.030	0	0
IKK complex recruitment mediated by RIP1	R-HSA-937041	9.603690e-02	1.018	0	0
APC/C:Cdc20 mediated degradation of Cyclin B	R-HSA-174048	9.603690e-02	1.018	0	0
Signaling by FGFR2 IIIa TM	R-HSA-8851708	9.603690e-02	1.018	0	0
Processing of Capped Intronless Pre-mRNA	R-HSA-75067	8.404944e-02	1.075	0	0
Recognition of DNA damage by PCNA-containing replication complex	R-HSA-110314	8.404944e-02	1.075	0	0
Nuclear Receptor transcription pathway	R-HSA-383280	9.708249e-02	1.013	0	0
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	R-HSA-141444	9.577112e-02	1.019	0	0
Amplification of signal from the kinetochores	R-HSA-141424	9.577112e-02	1.019	0	0
Transcriptional regulation of pluripotent stem cells	R-HSA-452723	8.668990e-02	1.062	0	0
Regulation of TP53 Activity through Association with Co-factors	R-HSA-6804759	9.335535e-02	1.030	0	0
Activation of PUMA and translocation to mitochondria	R-HSA-139915	8.043854e-02	1.095	0	0
Toll-like Receptor Cascades	R-HSA-168898	8.194111e-02	1.086	0	0
Mitotic Anaphase	R-HSA-68882	8.133046e-02	1.090	0	0
Mitotic Metaphase and Anaphase	R-HSA-2555396	8.464516e-02	1.072	0	0
RUNX3 regulates WNT signaling	R-HSA-8951430	8.043854e-02	1.095	0	0
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	R-HSA-8939246	9.975577e-02	1.001	0	0
Signaling by cytosolic FGFR1 fusion mutants	R-HSA-1839117	8.389271e-02	1.076	0	0
HIV Life Cycle	R-HSA-162587	8.028546e-02	1.095	0	0
G alpha (12/13) signalling events	R-HSA-416482	9.708249e-02	1.013	0	0
Regulation of MITF-M dependent genes involved in metabolism	R-HSA-9854907	9.034059e-02	1.044	0	0
Regulation of CDH1 Gene Transcription	R-HSA-9764560	9.806143e-02	1.009	0	0
Diseases of Mismatch Repair (MMR)	R-HSA-5423599	9.034059e-02	1.044	0	0
Apoptotic execution phase	R-HSA-75153	9.745823e-02	1.011	0	0
FGFR1 mutant receptor activation	R-HSA-1839124	1.006727e-01	0.997	0	0
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	R-HSA-73779	1.041155e-01	0.982	0	0
Formation of HIV elongation complex in the absence of HIV Tat	R-HSA-167152	1.041155e-01	0.982	0	0
Aggrephagy	R-HSA-9646399	1.041155e-01	0.982	0	0
Metalloprotease DUBs	R-HSA-5689901	1.055894e-01	0.976	0	0
EML4 and NUDC in mitotic spindle formation	R-HSA-9648025	1.067030e-01	0.972	0	0
Removal of the Flap Intermediate	R-HSA-69166	1.089061e-01	0.963	0	0
MAP3K8 (TPL2)-dependent MAPK1/3 activation	R-HSA-5684264	1.089061e-01	0.963	0	0
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	1.090192e-01	0.962	0	0
Separation of Sister Chromatids	R-HSA-2467813	1.097416e-01	0.960	0	0
NFE2L2 regulating anti-oxidant/detoxification enzymes	R-HSA-9818027	1.108552e-01	0.955	0	0
PKMTs methylate histone lysines	R-HSA-3214841	1.135052e-01	0.945	0	0
S Phase	R-HSA-69242	1.169357e-01	0.932	0	0
TNFR1-induced NF-kappa-B signaling pathway	R-HSA-5357956	1.173328e-01	0.931	0	0
Transcriptional regulation by RUNX1	R-HSA-8878171	1.186057e-01	0.926	0	0
TLR3-mediated TICAM1-dependent programmed cell death	R-HSA-9013957	1.220855e-01	0.913	0	0
RUNX3 regulates BCL2L11 (BIM) transcription	R-HSA-8952158	1.220855e-01	0.913	0	0
RUNX2 regulates genes involved in differentiation of myeloid cells	R-HSA-8941333	1.220855e-01	0.913	0	0
TGFBR1 KD Mutants in Cancer	R-HSA-3656532	1.220855e-01	0.913	0	0
IRF3 mediated activation of type 1 IFN	R-HSA-1606341	1.560393e-01	0.807	0	0
G2 Phase	R-HSA-68911	1.560393e-01	0.807	0	0
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	R-HSA-9673768	1.560393e-01	0.807	0	0
SMAD2/3 Phosphorylation Motif Mutants in Cancer	R-HSA-3304356	1.560393e-01	0.807	0	0
NFE2L2 regulating MDR associated enzymes	R-HSA-9818032	1.207231e-01	0.918	0	0
Activation of the AP-1 family of transcription factors	R-HSA-450341	1.207231e-01	0.918	0	0
WNT mediated activation of DVL	R-HSA-201688	1.207231e-01	0.918	0	0
2-LTR circle formation	R-HSA-164843	1.431386e-01	0.844	0	0
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	R-HSA-450513	1.255299e-01	0.901	0	0
Phosphorylation of the APC/C	R-HSA-176412	1.431457e-01	0.844	0	0
Aberrant regulation of mitotic exit in cancer due to RB1 defects	R-HSA-9687136	1.431457e-01	0.844	0	0
Ras activation upon Ca2+ influx through NMDA receptor	R-HSA-442982	1.373543e-01	0.862	0	0
HIV elongation arrest and recovery	R-HSA-167287	1.296979e-01	0.887	0	0
Pausing and recovery of HIV elongation	R-HSA-167290	1.296979e-01	0.887	0	0
SHC1 events in ERBB2 signaling	R-HSA-1250196	1.561895e-01	0.806	0	0
RNA Polymerase II HIV Promoter Escape	R-HSA-167162	1.233363e-01	0.909	0	0
HIV Transcription Initiation	R-HSA-167161	1.233363e-01	0.909	0	0
RNA Polymerase II Transcription Initiation	R-HSA-75953	1.233363e-01	0.909	0	0
RNA Polymerase II Promoter Escape	R-HSA-73776	1.442809e-01	0.841	0	0
Formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	1.315434e-01	0.881	0	0
RNA Polymerase II Transcription Termination	R-HSA-73856	1.597844e-01	0.796	0	0
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	R-HSA-6781827	1.349308e-01	0.870	0	0
Downstream signaling of activated FGFR2	R-HSA-5654696	1.327747e-01	0.877	0	0
FGFR2 mutant receptor activation	R-HSA-1839126	1.444806e-01	0.840	0	0
RNA Polymerase III Transcription Initiation	R-HSA-76046	1.561895e-01	0.806	0	0
Processive synthesis on the lagging strand	R-HSA-69183	1.255299e-01	0.901	0	0
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	1.233363e-01	0.909	0	0
Activation of NOXA and translocation to mitochondria	R-HSA-111448	1.220855e-01	0.913	0	0
FGFR2 ligand binding and activation	R-HSA-190241	1.228050e-01	0.911	0	0
Mitotic G1 phase and G1/S transition	R-HSA-453279	1.552402e-01	0.809	0	0
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	R-HSA-6804116	1.431457e-01	0.844	0	0
Activation of anterior HOX genes in hindbrain development during early embryogenesis	R-HSA-5617472	1.281024e-01	0.892	0	0
Activation of HOX genes during differentiation	R-HSA-5619507	1.281024e-01	0.892	0	0
Calcineurin activates NFAT	R-HSA-2025928	1.207231e-01	0.918	0	0
Late Phase of HIV Life Cycle	R-HSA-162599	1.316609e-01	0.881	0	0
Loss of Function of TGFBR1 in Cancer	R-HSA-3656534	1.560393e-01	0.807	0	0
Signal Transduction	R-HSA-162582	1.362833e-01	0.866	0	0
Regulation of HMOX1 expression and activity	R-HSA-9707587	1.220855e-01	0.913	0	0
NrCAM interactions	R-HSA-447038	1.560393e-01	0.807	0	0
Activation of the TFAP2 (AP-2) family of transcription factors	R-HSA-8866907	1.207231e-01	0.918	0	0
MECP2 regulates transcription of neuronal ligands	R-HSA-9022702	1.431386e-01	0.844	0	0
Transcriptional Regulation by NPAS4	R-HSA-9634815	1.530319e-01	0.815	0	0
Regulation of CDH11 gene transcription	R-HSA-9762293	1.207231e-01	0.918	0	0
Deactivation of the beta-catenin transactivating complex	R-HSA-3769402	1.566593e-01	0.805	0	0
MITF-M-dependent gene expression	R-HSA-9856651	1.273737e-01	0.895	0	0
NPAS4 regulates expression of target genes	R-HSA-9768919	1.215606e-01	0.915	0	0
IRE1alpha activates chaperones	R-HSA-381070	1.430519e-01	0.845	0	0
BMAL1:CLOCK,NPAS2 activates circadian expression	R-HSA-1368108	1.215606e-01	0.915	0	0
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	R-HSA-936964	1.616655e-01	0.791	0	0
Processing of Intronless Pre-mRNAs	R-HSA-77595	1.616655e-01	0.791	0	0
TRAF3-dependent IRF activation pathway	R-HSA-918233	1.616655e-01	0.791	0	0
mRNA decay by 5' to 3' exoribonuclease	R-HSA-430039	1.616655e-01	0.791	0	0
Meiotic synapsis	R-HSA-1221632	1.635615e-01	0.786	0	0
XBP1(S) activates chaperone genes	R-HSA-381038	1.637939e-01	0.786	0	0
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	1.650436e-01	0.782	0	0
Chylomicron assembly	R-HSA-8963888	1.667966e-01	0.778	0	0
Signaling by APC mutants	R-HSA-4839744	1.667966e-01	0.778	0	0
Truncations of AMER1 destabilize the destruction complex	R-HSA-5467348	1.667966e-01	0.778	0	0
AXIN missense mutants destabilize the destruction complex	R-HSA-5467340	1.667966e-01	0.778	0	0
APC truncation mutants have impaired AXIN binding	R-HSA-5467337	1.667966e-01	0.778	0	0
Formation of the posterior neural plate	R-HSA-9832991	1.667966e-01	0.778	0	0
RNA Polymerase II Transcription Initiation And Promoter Clearance	R-HSA-76042	1.668491e-01	0.778	0	0
Regulation of MITF-M-dependent genes involved in pigmentation	R-HSA-9824585	1.668491e-01	0.778	0	0
tRNA processing in the nucleus	R-HSA-6784531	1.698127e-01	0.770	0	0
Transcriptional regulation of granulopoiesis	R-HSA-9616222	1.698127e-01	0.770	0	0
Impaired BRCA2 binding to SEM1 (DSS1)	R-HSA-9763198	1.814523e-01	0.741	0	0
TICAM1 deficiency - HSE	R-HSA-5602566	1.814523e-01	0.741	0	0
Impaired BRCA2 translocation to the nucleus	R-HSA-9709275	1.814523e-01	0.741	0	0
Interactions of Tat with host cellular proteins	R-HSA-176034	2.594371e-01	0.586	0	0
Signaling by FGFR2 fusions	R-HSA-8853333	2.594371e-01	0.586	0	0
TGFBR3 regulates FGF2 signaling	R-HSA-9839397	2.594371e-01	0.586	0	0
Defective HK1 causes hexokinase deficiency (HK deficiency)	R-HSA-5619056	2.594371e-01	0.586	0	0
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	R-HSA-5619039	2.594371e-01	0.586	0	0
PTEN Loss of Function in Cancer	R-HSA-5674404	2.594371e-01	0.586	0	0
Intestinal infectious diseases	R-HSA-8942233	2.594371e-01	0.586	0	0
TWIK-releated acid-sensitive K+ channel (TASK)	R-HSA-1299316	2.594371e-01	0.586	0	0
TRAF3 deficiency - HSE	R-HSA-5602571	2.594371e-01	0.586	0	0
Defective SLC12A3 causes Gitelman syndrome (GS)	R-HSA-5619087	2.594371e-01	0.586	0	0
CDC6 association with the ORC:origin complex	R-HSA-68689	1.914937e-01	0.718	0	0
Loss of Function of SMAD2/3 in Cancer	R-HSA-3304349	1.914937e-01	0.718	0	0
CREB phosphorylation	R-HSA-199920	2.278552e-01	0.642	0	0
NFE2L2 regulates pentose phosphate pathway genes	R-HSA-9818028	1.914924e-01	0.718	0	0
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	R-HSA-9824878	1.914924e-01	0.718	0	0
Signaling by GSK3beta mutants	R-HSA-5339716	1.914924e-01	0.718	0	0
SHC-related events triggered by IGF1R	R-HSA-2428933	2.170269e-01	0.663	0	0
Signaling by CTNNB1 phospho-site mutants	R-HSA-4839743	2.170269e-01	0.663	0	0
Scavenging by Class F Receptors	R-HSA-3000484	2.170269e-01	0.663	0	0
CTNNB1 S33 mutants aren't phosphorylated	R-HSA-5358747	2.170269e-01	0.663	0	0
CTNNB1 S37 mutants aren't phosphorylated	R-HSA-5358749	2.170269e-01	0.663	0	0
CTNNB1 S45 mutants aren't phosphorylated	R-HSA-5358751	2.170269e-01	0.663	0	0
CTNNB1 T41 mutants aren't phosphorylated	R-HSA-5358752	2.170269e-01	0.663	0	0
Chylomicron remodeling	R-HSA-8963901	2.432090e-01	0.614	0	0
FGFR2c ligand binding and activation	R-HSA-190375	2.432090e-01	0.614	0	0
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	R-HSA-9661069	2.432090e-01	0.614	0	0
Translesion Synthesis by POLH	R-HSA-110320	2.217136e-01	0.654	0	0
Stabilization of p53	R-HSA-69541	1.823492e-01	0.739	1	1
Formation of HIV-1 elongation complex containing HIV-1 Tat	R-HSA-167200	1.823492e-01	0.739	0	0
EPHA-mediated growth cone collapse	R-HSA-3928663	2.379144e-01	0.624	0	0
Tat-mediated HIV elongation arrest and recovery	R-HSA-167243	2.379144e-01	0.624	0	0
Pausing and recovery of Tat-mediated HIV elongation	R-HSA-167238	2.379144e-01	0.624	0	0
Transport of the SLBP Dependant Mature mRNA	R-HSA-159230	2.153360e-01	0.667	0	0
Transport of Mature mRNAs Derived from Intronless Transcripts	R-HSA-159234	1.958127e-01	0.708	0	0
Tat-mediated elongation of the HIV-1 transcript	R-HSA-167246	1.958127e-01	0.708	0	0
Formation of TC-NER Pre-Incision Complex	R-HSA-6781823	1.787038e-01	0.748	0	0
FRS-mediated FGFR2 signaling	R-HSA-5654700	2.563682e-01	0.591	0	0
Formation of the Early Elongation Complex	R-HSA-113418	2.563682e-01	0.591	0	0
Gap-filling DNA repair synthesis and ligation in TC-NER	R-HSA-6782210	1.971005e-01	0.705	0	0
mRNA 3'-end processing	R-HSA-72187	2.566368e-01	0.591	0	0
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	R-HSA-174184	2.566368e-01	0.591	0	0
UCH proteinases	R-HSA-5689603	2.262080e-01	0.645	0	0
PTEN Regulation	R-HSA-6807070	2.257049e-01	0.646	0	0
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	2.497472e-01	0.602	0	0
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	R-HSA-110313	2.096543e-01	0.678	0	0
Nucleotide Excision Repair	R-HSA-5696398	2.018768e-01	0.695	0	0
TAK1-dependent IKK and NF-kappa-B activation	R-HSA-445989	1.909157e-01	0.719	0	0
HIV Transcription Elongation	R-HSA-167169	1.958127e-01	0.708	0	0
KEAP1-NFE2L2 pathway	R-HSA-9755511	2.561387e-01	0.592	0	0
Formation of definitive endoderm	R-HSA-9823730	2.429055e-01	0.615	0	0
p53-Dependent G1 DNA Damage Response	R-HSA-69563	2.163344e-01	0.665	1	0
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	2.163344e-01	0.665	1	0
FOXO-mediated transcription	R-HSA-9614085	2.191517e-01	0.659	0	0
Activated point mutants of FGFR2	R-HSA-2033519	2.010453e-01	0.697	0	0
Formation of Incision Complex in GG-NER	R-HSA-5696395	1.958127e-01	0.708	0	0
Activation of NF-kappaB in B cells	R-HSA-1169091	2.429419e-01	0.614	0	0
Global Genome Nucleotide Excision Repair (GG-NER)	R-HSA-5696399	2.172781e-01	0.663	0	0
p75NTR recruits signalling complexes	R-HSA-209543	2.170269e-01	0.663	0	0
Integration of provirus	R-HSA-162592	1.914924e-01	0.718	0	0
PI-3K cascade:FGFR2	R-HSA-5654695	2.022281e-01	0.694	0	0
Signaling by WNT in cancer	R-HSA-4791275	1.848276e-01	0.733	0	0
Aryl hydrocarbon receptor signalling	R-HSA-8937144	1.914937e-01	0.718	0	0
Formation of the HIV-1 Early Elongation Complex	R-HSA-167158	2.563682e-01	0.591	0	0
G1/S DNA Damage Checkpoints	R-HSA-69615	1.801325e-01	0.744	1	0
Downregulation of SMAD2/3:SMAD4 transcriptional activity	R-HSA-2173795	1.848276e-01	0.733	0	0
TRAF6 mediated NF-kB activation	R-HSA-933542	1.851128e-01	0.733	0	0
Deadenylation of mRNA	R-HSA-429947	1.851128e-01	0.733	0	0
PIP3 activates AKT signaling	R-HSA-1257604	2.333761e-01	0.632	0	0
Germ layer formation at gastrulation	R-HSA-9754189	2.217136e-01	0.654	0	0
Repression of WNT target genes	R-HSA-4641265	2.170269e-01	0.663	0	0
MET activates RAS signaling	R-HSA-8851805	2.170269e-01	0.663	0	0
Signaling by NOTCH	R-HSA-157118	1.862791e-01	0.730	0	0
Selective autophagy	R-HSA-9663891	1.811890e-01	0.742	1	0
Signaling by ERBB2	R-HSA-1227986	2.458179e-01	0.609	0	0
Nef mediated downregulation of CD28 cell surface expression	R-HSA-164939	2.594371e-01	0.586	0	0
DNA strand elongation	R-HSA-69190	1.848276e-01	0.733	0	0
IGF1R signaling cascade	R-HSA-2428924	1.907331e-01	0.720	0	0
Regulation of MECP2 expression and activity	R-HSA-9022692	1.998664e-01	0.699	0	0
DDX58/IFIH1-mediated induction of interferon-alpha/beta	R-HSA-168928	2.586767e-01	0.587	0	0
Autophagy	R-HSA-9612973	2.234467e-01	0.651	1	0
Semaphorin interactions	R-HSA-373755	1.801325e-01	0.744	0	0
Signaling by FGFR1 in disease	R-HSA-5655302	2.238469e-01	0.650	0	0
Signaling by FLT3 fusion proteins	R-HSA-9703465	2.198480e-01	0.658	0	0
Macroautophagy	R-HSA-1632852	2.417387e-01	0.617	1	0
Signaling by NOTCH4	R-HSA-9013694	2.048742e-01	0.689	0	0
Signaling by NODAL	R-HSA-1181150	2.429055e-01	0.615	0	0
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	2.016027e-01	0.696	0	0
Neurexins and neuroligins	R-HSA-6794361	2.566368e-01	0.591	0	0
Signaling by TGF-beta Receptor Complex in Cancer	R-HSA-3304351	2.278552e-01	0.642	0	0
M-decay: degradation of maternal mRNAs by maternally stored factors	R-HSA-9820841	2.096543e-01	0.678	0	0
TBC/RABGAPs	R-HSA-8854214	2.531708e-01	0.597	0	0
Rab regulation of trafficking	R-HSA-9007101	2.458561e-01	0.609	0	0
Formation of editosomes by ADAR proteins	R-HSA-77042	1.814523e-01	0.741	0	0
SDK interactions	R-HSA-373756	1.814523e-01	0.741	0	0
Inhibition of Host mRNA Processing and RNA Silencing	R-HSA-168315	2.594371e-01	0.586	0	0
RUNX1 regulates transcription of genes involved in WNT signaling	R-HSA-8939256	2.278552e-01	0.642	0	0
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	R-HSA-9659787	2.432090e-01	0.614	0	0
Serotonin Neurotransmitter Release Cycle	R-HSA-181429	2.010453e-01	0.697	0	0
Signaling by NOTCH2	R-HSA-1980145	2.311976e-01	0.636	0	0
Deadenylation-dependent mRNA decay	R-HSA-429914	2.332587e-01	0.632	0	0
Signaling by Receptor Tyrosine Kinases	R-HSA-9006934	1.827869e-01	0.738	0	0
SARS-CoV-2 activates/modulates innate and adaptive immune responses	R-HSA-9705671	2.582284e-01	0.588	0	0
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	R-HSA-442742	1.998664e-01	0.699	0	0
PI3K/AKT Signaling in Cancer	R-HSA-2219528	1.793949e-01	0.746	0	0
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	R-HSA-9029569	2.209414e-01	0.656	0	0
Transcriptional Regulation by VENTX	R-HSA-8853884	2.096543e-01	0.678	0	0
Breakdown of the nuclear lamina	R-HSA-352238	2.594371e-01	0.586	0	0
RUNX1 regulates expression of components of tight junctions	R-HSA-8935964	1.914937e-01	0.718	0	0
AKT phosphorylates targets in the cytosol	R-HSA-198323	2.170269e-01	0.663	0	0
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	R-HSA-9860927	2.474115e-01	0.607	0	0
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	R-HSA-8869496	2.278552e-01	0.642	0	0
ATF4 activates genes in response to endoplasmic reticulum stress	R-HSA-380994	2.563682e-01	0.591	0	0
PERK regulates gene expression	R-HSA-381042	2.474115e-01	0.607	0	0
MITF-M-regulated melanocyte development	R-HSA-9730414	2.477974e-01	0.606	0	0
Signaling by ALK	R-HSA-201556	1.823492e-01	0.739	0	0
Specification of primordial germ cells	R-HSA-9827857	1.809971e-01	0.742	0	0
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	R-HSA-9926550	2.010453e-01	0.697	0	0
MECP2 regulates neuronal receptors and channels	R-HSA-9022699	2.198480e-01	0.658	0	0
Degradation of beta-catenin by the destruction complex	R-HSA-195253	2.595351e-01	0.586	0	0
RNA Polymerase III Transcription	R-HSA-74158	2.639375e-01	0.578	0	0
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	2.639375e-01	0.578	0	0
FLT3 signaling in disease	R-HSA-9682385	2.639375e-01	0.578	0	0
TNFR1-induced proapoptotic signaling	R-HSA-5357786	2.645257e-01	0.578	0	0
Lagging Strand Synthesis	R-HSA-69186	2.645257e-01	0.578	0	0
ERK/MAPK targets	R-HSA-198753	2.645257e-01	0.578	0	0
TRIF-mediated programmed cell death	R-HSA-2562578	2.646296e-01	0.577	0	0
PTK6 Expression	R-HSA-8849473	2.646296e-01	0.577	0	0
Cation-coupled Chloride cotransporters	R-HSA-426117	2.646296e-01	0.577	0	0
RUNX1 regulates estrogen receptor mediated transcription	R-HSA-8931987	2.646296e-01	0.577	0	0
RUNX3 Regulates Immune Response and Cell Migration	R-HSA-8949275	2.646296e-01	0.577	0	0
RMTs methylate histone arginines	R-HSA-3214858	2.682435e-01	0.571	0	0
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	R-HSA-8864260	2.682435e-01	0.571	0	0
TGFBR3 regulates activin signaling	R-HSA-9839406	3.299963e-01	0.481	0	0
Signalling to ERK5	R-HSA-198765	3.299963e-01	0.481	0	0
HHAT G278V doesn't palmitoylate Hh-Np	R-HSA-5658034	3.299963e-01	0.481	0	0
Defective ALG14 causes ALG14-CMS	R-HSA-5633231	3.299963e-01	0.481	0	0
The NLRP1 inflammasome	R-HSA-844455	3.938365e-01	0.405	0	0
TFAP2 (AP-2) family regulates transcription of other transcription factors	R-HSA-8866906	3.938365e-01	0.405	0	0
Activation of BMF and translocation to mitochondria	R-HSA-139910	3.938365e-01	0.405	0	0
Signaling by plasma membrane FGFR1 fusions	R-HSA-8853336	3.938365e-01	0.405	0	0
Defective GCLC causes HAGGSD	R-HSA-5578999	3.938365e-01	0.405	0	0
Defective ABCC2 causes DJS	R-HSA-5679001	3.938365e-01	0.405	0	0
Defective ABCA1 causes TGD	R-HSA-5682113	3.938365e-01	0.405	0	0
Loss of Function of KMT2D in Kabuki Syndrome	R-HSA-9944971	3.938365e-01	0.405	0	0
Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	R-HSA-9944997	3.938365e-01	0.405	0	0
Type I hemidesmosome assembly	R-HSA-446107	3.014086e-01	0.521	0	0
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	R-HSA-77588	3.014086e-01	0.521	0	0
TGFBR3 PTM regulation	R-HSA-9839383	3.014086e-01	0.521	0	0
ARMS-mediated activation	R-HSA-170984	3.378577e-01	0.471	0	0
ALK mutants bind TKIs	R-HSA-9700645	3.378577e-01	0.471	0	0
AKT-mediated inactivation of FOXO1A	R-HSA-211163	4.515973e-01	0.345	0	0
Signaling by LRP5 mutants	R-HSA-5339717	4.515973e-01	0.345	0	0
Defective LFNG causes SCDO3	R-HSA-5083630	4.515973e-01	0.345	0	0
GRB7 events in ERBB2 signaling	R-HSA-1306955	4.515973e-01	0.345	0	0
Spry regulation of FGF signaling	R-HSA-1295596	2.968055e-01	0.528	0	0
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	R-HSA-450385	2.968055e-01	0.528	0	0
Translesion synthesis by REV1	R-HSA-110312	2.968055e-01	0.528	0	0
Beta-catenin phosphorylation cascade	R-HSA-196299	2.968055e-01	0.528	0	0
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	3.737061e-01	0.427	0	0
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	R-HSA-5140745	3.737061e-01	0.427	0	0
Translesion synthesis by POLI	R-HSA-5656121	3.238954e-01	0.490	0	0
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	3.086821e-01	0.510	0	0
Translesion synthesis by POLK	R-HSA-5655862	3.509852e-01	0.455	0	0
RUNX2 regulates genes involved in cell migration	R-HSA-8941332	4.087377e-01	0.389	0	0
Activated NTRK3 signals through RAS	R-HSA-9034864	4.087377e-01	0.389	0	0
NFE2L2 regulating TCA cycle genes	R-HSA-9818025	5.038571e-01	0.298	0	0
IRS activation	R-HSA-74713	5.038571e-01	0.298	0	0
FGFR1c and Klotho ligand binding and activation	R-HSA-190374	5.038571e-01	0.298	0	0
FLT3 signaling by CBL mutants	R-HSA-9706377	5.038571e-01	0.298	0	0
Signaling by EGFRvIII in Cancer	R-HSA-5637812	3.779460e-01	0.423	0	0
Constitutive Signaling by EGFRvIII	R-HSA-5637810	3.779460e-01	0.423	0	0
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	3.779460e-01	0.423	0	0
EGFR downregulation	R-HSA-182971	3.134690e-01	0.504	0	0
Activated NTRK2 signals through RAS	R-HSA-9026519	4.427826e-01	0.354	0	0
ERKs are inactivated	R-HSA-202670	4.427826e-01	0.354	0	0
Amino acids regulate mTORC1	R-HSA-9639288	2.705621e-01	0.568	0	0
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	R-HSA-179419	2.705621e-01	0.568	0	0
Transport of Mature mRNA Derived from an Intronless Transcript	R-HSA-159231	3.149808e-01	0.502	0	0
PCNA-Dependent Long Patch Base Excision Repair	R-HSA-5651801	4.046622e-01	0.393	0	0
Transport of the SLBP independent Mature mRNA	R-HSA-159227	3.524152e-01	0.453	0	0
Attenuation phase	R-HSA-3371568	3.323490e-01	0.478	0	0
APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176409	2.990109e-01	0.524	0	0
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	R-HSA-176814	3.134871e-01	0.504	0	0
Abortive elongation of HIV-1 transcript in the absence of Tat	R-HSA-167242	4.310315e-01	0.365	0	0
RUNX3 regulates p14-ARF	R-HSA-8951936	4.757111e-01	0.323	0	0
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	R-HSA-9931530	4.757111e-01	0.323	0	0
Transport of Mature Transcript to Cytoplasm	R-HSA-72202	2.948087e-01	0.530	0	0
Interaction between L1 and Ankyrins	R-HSA-445095	4.205000e-01	0.376	0	0
Nephrin family interactions	R-HSA-373753	4.569638e-01	0.340	0	0
Nuclear Pore Complex (NPC) Disassembly	R-HSA-3301854	4.110868e-01	0.386	0	0
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	R-HSA-9845323	3.725201e-01	0.429	0	0
Negative regulation of FGFR3 signaling	R-HSA-5654732	4.425207e-01	0.354	0	0
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	4.823815e-01	0.317	0	0
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	4.823815e-01	0.317	0	0
SHC-mediated cascade:FGFR3	R-HSA-5654704	4.823815e-01	0.317	0	0
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	R-HSA-450321	4.823815e-01	0.317	0	0
Negative regulation of FGFR4 signaling	R-HSA-5654733	4.642826e-01	0.333	0	0
Regulation of gene expression in beta cells	R-HSA-210745	4.642826e-01	0.333	0	0
Late endosomal microautophagy	R-HSA-9615710	4.642826e-01	0.333	0	0
Degradation of DVL	R-HSA-4641258	4.498127e-01	0.347	0	0
Vpr-mediated nuclear import of PICs	R-HSA-180910	4.498127e-01	0.347	0	0
Transcriptional regulation by RUNX2	R-HSA-8878166	3.569769e-01	0.447	0	0
Transport of Mature mRNA derived from an Intron-Containing Transcript	R-HSA-159236	4.226392e-01	0.374	0	0
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	R-HSA-5619107	4.857346e-01	0.314	0	0
Unblocking of NMDA receptors, glutamate binding and activation	R-HSA-438066	5.072179e-01	0.295	0	0
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	5.072179e-01	0.295	0	0
SHC-mediated cascade:FGFR4	R-HSA-5654719	5.072179e-01	0.295	0	0
Gap-filling DNA repair synthesis and ligation in GG-NER	R-HSA-5696397	5.072179e-01	0.295	0	0
Prolactin receptor signaling	R-HSA-1170546	5.378616e-01	0.269	0	0
Regulation of CDH1 mRNA translation by microRNAs	R-HSA-9764562	5.378616e-01	0.269	0	0
APC/C:Cdc20 mediated degradation of Securin	R-HSA-174154	4.722245e-01	0.326	0	0
IP3 and IP4 transport between cytosol and nucleus	R-HSA-1855196	5.068306e-01	0.295	0	0
IP6 and IP7 transport between cytosol and nucleus	R-HSA-1855229	5.068306e-01	0.295	0	0
Developmental Lineage of Multipotent Pancreatic Progenitor Cells	R-HSA-9937080	5.275297e-01	0.278	0	0
NIK-->noncanonical NF-kB signaling	R-HSA-5676590	5.248818e-01	0.280	0	0
Post-translational protein phosphorylation	R-HSA-8957275	5.298783e-01	0.276	0	0
Nuclear events mediated by NFE2L2	R-HSA-9759194	4.835403e-01	0.316	0	0
Signaling by FGFR2 in disease	R-HSA-5655253	3.625329e-01	0.441	0	0
Regulation of endogenous retroelements	R-HSA-9842860	4.580470e-01	0.339	0	0
Signaling by FGFR2	R-HSA-5654738	2.712734e-01	0.567	0	0
Signaling by FGFR3	R-HSA-5654741	4.375873e-01	0.359	0	0
Signaling by FGFR4	R-HSA-5654743	4.025532e-01	0.395	0	0
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	R-HSA-9818564	3.316754e-01	0.479	0	0
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	3.946286e-01	0.404	0	0
Regulation of mitotic cell cycle	R-HSA-453276	3.946286e-01	0.404	0	0
Signaling by FGFR	R-HSA-190236	3.012575e-01	0.521	0	0
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	R-HSA-9851695	3.316754e-01	0.479	0	0
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	R-HSA-9841922	3.316754e-01	0.479	0	0
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	R-HSA-3371497	4.913335e-01	0.309	0	0
Synthesis of IPs in the nucleus	R-HSA-1855191	5.378616e-01	0.269	0	0
Signaling by FGFR1	R-HSA-5654736	3.134871e-01	0.504	0	0
Termination of translesion DNA synthesis	R-HSA-5656169	2.751507e-01	0.560	0	0
Signal attenuation	R-HSA-74749	3.737061e-01	0.427	0	0
Regulation of APC/C activators between G1/S and early anaphase	R-HSA-176408	2.715900e-01	0.566	0	0
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	R-HSA-9844594	3.323490e-01	0.478	0	0
Transcriptional regulation of brown and beige adipocyte differentiation	R-HSA-9843743	3.323490e-01	0.478	0	0
TP53 Regulates Transcription of Death Receptors and Ligands	R-HSA-6803211	5.378616e-01	0.269	0	0
Pexophagy	R-HSA-9664873	3.737061e-01	0.427	1	1
Plasma lipoprotein assembly	R-HSA-8963898	3.534783e-01	0.452	0	0
Extension of Telomeres	R-HSA-180786	3.576394e-01	0.447	0	0
G1/S Transition	R-HSA-69206	5.375875e-01	0.270	0	0
Regulation of localization of FOXO transcription factors	R-HSA-9614399	4.087377e-01	0.389	0	0
DNA Damage Recognition in GG-NER	R-HSA-5696394	3.719890e-01	0.429	0	0
Clathrin-mediated endocytosis	R-HSA-8856828	3.512011e-01	0.454	0	0
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	5.314171e-01	0.275	0	0
Signaling by Leptin	R-HSA-2586552	3.737061e-01	0.427	0	0
Chaperone Mediated Autophagy	R-HSA-9613829	4.046622e-01	0.393	0	0
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	R-HSA-6804115	3.086821e-01	0.510	0	0
p75NTR signals via NF-kB	R-HSA-193639	2.968055e-01	0.528	0	0
TRAF6 mediated IRF7 activation	R-HSA-933541	4.498127e-01	0.347	0	0
TP53 Regulates Transcription of Caspase Activators and Caspases	R-HSA-6803207	3.238954e-01	0.490	1	1
Unwinding of DNA	R-HSA-176974	3.378577e-01	0.471	0	0
TFAP2 (AP-2) family regulates transcription of cell cycle factors	R-HSA-8866911	4.515973e-01	0.345	0	0
Role of second messengers in netrin-1 signaling	R-HSA-418890	4.757111e-01	0.323	0	0
RNA Polymerase I Transcription Termination	R-HSA-73863	4.205000e-01	0.376	0	0
Nuclear RNA decay	R-HSA-9930044	3.524152e-01	0.453	0	0
TCF dependent signaling in response to WNT	R-HSA-201681	3.747011e-01	0.426	0	0
Insulin receptor signalling cascade	R-HSA-74751	4.322570e-01	0.364	0	0
Downregulation of ERBB2 signaling	R-HSA-8863795	2.942035e-01	0.531	0	0
Energy dependent regulation of mTOR by LKB1-AMPK	R-HSA-380972	4.857346e-01	0.314	0	0
Interleukin-1 signaling	R-HSA-9020702	4.460911e-01	0.351	0	0
Signaling by ERBB2 in Cancer	R-HSA-1227990	2.942035e-01	0.531	0	0
Interleukin-6 signaling	R-HSA-1059683	5.074267e-01	0.295	0	0
Signaling by ERBB2 TMD/JMD mutants	R-HSA-9665686	3.534783e-01	0.452	0	0
TP53 Regulates Transcription of Cell Cycle Genes	R-HSA-6791312	3.280997e-01	0.484	0	0
Killing mechanisms	R-HSA-9664420	3.238954e-01	0.490	0	0
WNT5:FZD7-mediated leishmania damping	R-HSA-9673324	3.238954e-01	0.490	0	0
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	3.509852e-01	0.455	0	0
FGFR2b ligand binding and activation	R-HSA-190377	4.087377e-01	0.389	0	0
Post-transcriptional silencing by small RNAs	R-HSA-426496	5.038571e-01	0.298	0	0
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	R-HSA-9623433	4.427826e-01	0.354	0	0
RNA Polymerase I Transcription Initiation	R-HSA-73762	3.849669e-01	0.415	0	0
FGFR1c ligand binding and activation	R-HSA-190373	5.074267e-01	0.295	0	0
Antigen processing: Ubiquitination & Proteasome degradation	R-HSA-983168	4.686440e-01	0.329	0	0
Cellular response to chemical stress	R-HSA-9711123	5.126926e-01	0.290	0	0
Diseases of Immune System	R-HSA-5260271	3.323490e-01	0.478	0	0
Diseases associated with the TLR signaling cascade	R-HSA-5602358	3.323490e-01	0.478	0	0
Synthesis of DNA	R-HSA-69239	5.287571e-01	0.277	0	0
InlB-mediated entry of Listeria monocytogenes into host cell	R-HSA-8875360	2.968055e-01	0.528	0	0
Oxidative Stress Induced Senescence	R-HSA-2559580	3.455987e-01	0.461	0	0
Regulation of PD-L1(CD274) expression	R-HSA-9909648	3.627999e-01	0.440	0	0
Intracellular signaling by second messengers	R-HSA-9006925	4.061402e-01	0.391	0	0
Transcriptional activation of p53 responsive genes	R-HSA-69560	4.515973e-01	0.345	0	0
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	4.515973e-01	0.345	0	0
SARS-CoV-1-mediated effects on programmed cell death	R-HSA-9692913	4.515973e-01	0.345	0	0
Signaling by Activin	R-HSA-1502540	2.968055e-01	0.528	0	0
TET1,2,3 and TDG demethylate DNA	R-HSA-5221030	3.737061e-01	0.427	0	0
RUNX1 regulates transcription of genes involved in interleukin signaling	R-HSA-8939247	5.038571e-01	0.298	0	0
Polo-like kinase mediated events	R-HSA-156711	4.046622e-01	0.393	0	0
Intra-Golgi traffic	R-HSA-6811438	3.673798e-01	0.435	0	0
Cargo recognition for clathrin-mediated endocytosis	R-HSA-8856825	3.682282e-01	0.434	0	0
Interleukin-4 and Interleukin-13 signaling	R-HSA-6785807	4.529844e-01	0.344	0	0
Pre-NOTCH Transcription and Translation	R-HSA-1912408	3.040734e-01	0.517	0	0
ER to Golgi Anterograde Transport	R-HSA-199977	3.012077e-01	0.521	0	0
Signaling by Insulin receptor	R-HSA-74752	3.271392e-01	0.485	0	0
Signaling by ERBB2 KD Mutants	R-HSA-9664565	4.642826e-01	0.333	0	0
Mitotic Prophase	R-HSA-68875	4.725770e-01	0.326	0	0
COPI-mediated anterograde transport	R-HSA-6807878	3.861973e-01	0.413	0	0
Nuclear Envelope (NE) Reassembly	R-HSA-2995410	5.192656e-01	0.285	0	0
Activation of BH3-only proteins	R-HSA-114452	2.942035e-01	0.531	0	0
Initiation of Nuclear Envelope (NE) Reformation	R-HSA-2995383	2.864813e-01	0.543	0	0
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	3.086821e-01	0.510	0	0
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	3.779460e-01	0.423	0	0
Regulation of TP53 Activity through Acetylation	R-HSA-6804758	3.524152e-01	0.453	0	0
Mitochondrial unfolded protein response (UPRmt)	R-HSA-9841251	4.205000e-01	0.376	0	0
RAB GEFs exchange GTP for GDP on RABs	R-HSA-8876198	4.665941e-01	0.331	0	0
DNA Replication Pre-Initiation	R-HSA-69002	4.369784e-01	0.360	0	0
Signaling by EGFR	R-HSA-177929	3.134871e-01	0.504	0	0
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	4.025532e-01	0.395	0	0
Listeria monocytogenes entry into host cells	R-HSA-8876384	2.864813e-01	0.543	0	0
Nuclear Envelope Breakdown	R-HSA-2980766	4.747180e-01	0.324	0	0
Signaling by ERBB2 ECD mutants	R-HSA-9665348	4.046622e-01	0.393	0	0
Caspase activation via extrinsic apoptotic signalling pathway	R-HSA-5357769	3.982772e-01	0.400	0	0
Formation of the nephric duct	R-HSA-9830364	3.759142e-01	0.425	0	0
Membrane Trafficking	R-HSA-199991	2.815343e-01	0.550	0	0
HIV Infection	R-HSA-162906	3.490462e-01	0.457	0	0
mRNA Editing: A to I Conversion	R-HSA-75064	3.299963e-01	0.481	0	0
C6 deamination of adenosine	R-HSA-75102	3.299963e-01	0.481	0	0
Activation of BIM and translocation to mitochondria	R-HSA-111446	3.938365e-01	0.405	0	0
MET interacts with TNS proteins	R-HSA-8875513	3.938365e-01	0.405	0	0
Adenosine P1 receptors	R-HSA-417973	3.938365e-01	0.405	0	0
Caspase activation via Dependence Receptors in the absence of ligand	R-HSA-418889	3.378577e-01	0.471	0	0
Inhibition of TSC complex formation by PKB	R-HSA-165181	4.515973e-01	0.345	0	0
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	4.087377e-01	0.389	0	0
Ionotropic activity of kainate receptors	R-HSA-451306	4.087377e-01	0.389	0	0
Bicarbonate transporters	R-HSA-425381	4.087377e-01	0.389	0	0
Reelin signalling pathway	R-HSA-8866376	5.038571e-01	0.298	0	0
RUNX1 regulates transcription of genes involved in BCR signaling	R-HSA-8939245	5.038571e-01	0.298	0	0
Ovarian tumor domain proteases	R-HSA-5689896	2.807348e-01	0.552	0	0
NF-kB is activated and signals survival	R-HSA-209560	4.427826e-01	0.354	0	0
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	3.915621e-01	0.407	0	0
Membrane binding and targetting of GAG proteins	R-HSA-174490	5.074267e-01	0.295	0	0
Platelet calcium homeostasis	R-HSA-418360	4.642826e-01	0.333	0	0
Activation of gene expression by SREBF (SREBP)	R-HSA-2426168	4.173341e-01	0.380	0	0
Trafficking of AMPA receptors	R-HSA-399719	5.068306e-01	0.295	0	0
Interactions of Vpr with host cellular proteins	R-HSA-176033	5.064988e-01	0.295	0	0
IRS-related events triggered by IGF1R	R-HSA-2428928	5.366787e-01	0.270	0	0
Signaling by Nuclear Receptors	R-HSA-9006931	2.961817e-01	0.528	0	0
Regulation of Expression and Function of Type I Classical Cadherins	R-HSA-9764274	3.715848e-01	0.430	0	0
Regulation of CDH1 Expression and Function	R-HSA-9764265	3.715848e-01	0.430	0	0
Cyclin D associated events in G1	R-HSA-69231	4.201044e-01	0.377	0	0
G1 Phase	R-HSA-69236	4.201044e-01	0.377	0	0
NR1H2 and NR1H3-mediated signaling	R-HSA-9024446	3.480226e-01	0.458	0	0
Cilium Assembly	R-HSA-5617833	2.770815e-01	0.557	0	0
Negative Regulation of CDH1 Gene Transcription	R-HSA-9764725	3.725201e-01	0.429	0	0
The NLRP3 inflammasome	R-HSA-844456	4.310315e-01	0.365	0	0
IRS-mediated signalling	R-HSA-112399	4.747180e-01	0.324	0	0
Regulation of cholesterol biosynthesis by SREBP (SREBF)	R-HSA-1655829	5.057208e-01	0.296	0	0
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	4.322570e-01	0.364	0	0
PTK6 Regulates Proteins Involved in RNA Processing	R-HSA-8849468	5.038571e-01	0.298	0	0
Inflammasomes	R-HSA-622312	4.425207e-01	0.354	0	0
MAPK6/MAPK4 signaling	R-HSA-5687128	4.534582e-01	0.343	0	0
Negative regulation of MET activity	R-HSA-6807004	4.569638e-01	0.340	0	0
Evasion by RSV of host interferon responses	R-HSA-9833109	5.068306e-01	0.295	0	0
Formation of paraxial mesoderm	R-HSA-9793380	3.874442e-01	0.412	0	0
HDMs demethylate histones	R-HSA-3214842	3.759142e-01	0.425	0	0
Dopamine Neurotransmitter Release Cycle	R-HSA-212676	3.086821e-01	0.510	0	0
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	R-HSA-75035	5.074267e-01	0.295	0	0
Synthesis And Processing Of GAG, GAGPOL Polyproteins	R-HSA-174495	5.378616e-01	0.269	0	0
Protein-protein interactions at synapses	R-HSA-6794362	3.310719e-01	0.480	0	0
Defective Intrinsic Pathway for Apoptosis	R-HSA-9734009	4.205000e-01	0.376	0	0
CLEC7A (Dectin-1) signaling	R-HSA-5607764	5.055206e-01	0.296	0	0
DSCAM interactions	R-HSA-376172	3.299963e-01	0.481	0	0
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	2.698581e-01	0.569	0	0
Regulation of the apoptosome activity	R-HSA-9627069	3.737061e-01	0.427	0	0
Reduction of cytosolic Ca++ levels	R-HSA-418359	4.427826e-01	0.354	0	0
Insulin receptor recycling	R-HSA-77387	4.425207e-01	0.354	0	0
Acetylcholine Neurotransmitter Release Cycle	R-HSA-264642	4.823815e-01	0.317	0	0
NS1 Mediated Effects on Host Pathways	R-HSA-168276	4.878385e-01	0.312	0	0
Programmed Cell Death	R-HSA-5357801	4.882232e-01	0.311	0	0
Signaling by NTRK3 (TRKC)	R-HSA-9034015	5.072179e-01	0.295	0	0
Early Phase of HIV Life Cycle	R-HSA-162594	4.823815e-01	0.317	0	0
Formation of apoptosome	R-HSA-111458	3.737061e-01	0.427	0	0
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	R-HSA-9735871	2.968055e-01	0.528	0	0
Cyclin A/B1/B2 associated events during G2/M transition	R-HSA-69273	3.524152e-01	0.453	0	0
Maternal to zygotic transition (MZT)	R-HSA-9816359	3.991993e-01	0.399	0	0
Apoptosis	R-HSA-109581	2.699045e-01	0.569	0	0
Resolution of Abasic Sites (AP sites)	R-HSA-73933	5.248818e-01	0.280	0	0
STAT3 nuclear events downstream of ALK signaling	R-HSA-9701898	2.968055e-01	0.528	0	0
Cytochrome c-mediated apoptotic response	R-HSA-111461	4.427826e-01	0.354	0	0
PI5P Regulates TP53 Acetylation	R-HSA-6811555	5.074267e-01	0.295	0	0
Regulation of CDH11 Expression and Function	R-HSA-9759475	4.642826e-01	0.333	0	0
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	R-HSA-9825892	5.072179e-01	0.295	0	0
Negative regulation of NMDA receptor-mediated neuronal transmission	R-HSA-9617324	5.072179e-01	0.295	0	0
Intrinsic Pathway for Apoptosis	R-HSA-109606	4.588707e-01	0.338	0	0
Interleukin-7 signaling	R-HSA-1266695	3.759142e-01	0.425	0	0
Cytoprotection by HMOX1	R-HSA-9707564	3.067817e-01	0.513	0	0
FLT3 Signaling	R-HSA-9607240	5.248818e-01	0.280	0	0
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	3.014086e-01	0.521	0	0
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	R-HSA-9825895	3.014086e-01	0.521	0	0
Caspase-mediated cleavage of cytoskeletal proteins	R-HSA-264870	3.378577e-01	0.471	0	0
PKR-mediated signaling	R-HSA-9833482	3.874126e-01	0.412	0	0
Physiological factors	R-HSA-5578768	2.698581e-01	0.569	0	0
PI3K Cascade	R-HSA-109704	3.625329e-01	0.441	0	0
HSF1-dependent transactivation	R-HSA-3371571	5.394146e-01	0.268	0	0
Assembly and cell surface presentation of NMDA receptors	R-HSA-9609736	5.429595e-01	0.265	0	0
IPs transport between nucleus and cytosol	R-HSA-1855170	5.477960e-01	0.261	0	0
Negative regulation of FGFR1 signaling	R-HSA-5654726	5.477960e-01	0.261	0	0
Integrin signaling	R-HSA-354192	5.477960e-01	0.261	0	0
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	5.477960e-01	0.261	0	0
Glutamate binding, activation of AMPA receptors and synaptic plasticity	R-HSA-399721	5.477960e-01	0.261	0	0
Regulation of Expression and Function of Type II Classical Cadherins	R-HSA-9764260	5.477960e-01	0.261	0	0
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	5.485677e-01	0.261	0	0
Class I MHC mediated antigen processing & presentation	R-HSA-983169	5.498588e-01	0.260	0	0
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660825	5.511397e-01	0.259	0	0
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	R-HSA-2660826	5.511397e-01	0.259	0	0
Nef Mediated CD8 Down-regulation	R-HSA-182218	5.511397e-01	0.259	0	0
PTK6 Regulates Cell Cycle	R-HSA-8849470	5.511397e-01	0.259	0	0
SLIT2:ROBO1 increases RHOA activity	R-HSA-8985586	5.511397e-01	0.259	0	0
Phosphorylation of Emi1	R-HSA-176417	5.511397e-01	0.259	0	0
Signaling by RNF43 mutants	R-HSA-5340588	5.511397e-01	0.259	0	0
Loss of MECP2 binding ability to the NCoR/SMRT complex	R-HSA-9022537	5.511397e-01	0.259	0	0
Signaling by MAPK mutants	R-HSA-9652817	5.511397e-01	0.259	0	0
Toxicity of botulinum toxin type E (botE)	R-HSA-5250992	5.511397e-01	0.259	0	0
NGF-independant TRKA activation	R-HSA-187024	5.511397e-01	0.259	0	0
Noncanonical activation of NOTCH3	R-HSA-9017802	5.511397e-01	0.259	0	0
Negative feedback regulation of MAPK pathway	R-HSA-5674499	5.511397e-01	0.259	0	0
Signalling to p38 via RIT and RIN	R-HSA-187706	5.511397e-01	0.259	0	0
Relaxin receptors	R-HSA-444821	5.511397e-01	0.259	0	0
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	R-HSA-446388	5.511397e-01	0.259	0	0
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	5.537453e-01	0.257	0	0
Regulation of PTEN mRNA translation	R-HSA-8943723	5.549330e-01	0.256	0	0
RNA Pol II CTD phosphorylation and interaction with CE	R-HSA-77075	5.549330e-01	0.256	0	0
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	R-HSA-167160	5.549330e-01	0.256	0	0
Response of EIF2AK1 (HRI) to heme deficiency	R-HSA-9648895	5.549330e-01	0.256	0	0
mRNA Splicing - Major Pathway	R-HSA-72163	5.575049e-01	0.254	0	0
Switching of origins to a post-replicative state	R-HSA-69052	5.624707e-01	0.250	0	0
mRNA Splicing	R-HSA-72172	5.646931e-01	0.248	0	0
Signaling by Non-Receptor Tyrosine Kinases	R-HSA-9006927	5.665389e-01	0.247	0	0
Signaling by PTK6	R-HSA-8848021	5.665389e-01	0.247	0	0
Erythropoietin activates RAS	R-HSA-9027284	5.669719e-01	0.246	0	0
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	R-HSA-2173791	5.669719e-01	0.246	0	0
Sema3A PAK dependent Axon repulsion	R-HSA-399954	5.669719e-01	0.246	0	0
Telomere C-strand synthesis initiation	R-HSA-174430	5.669719e-01	0.246	0	0
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	5.675982e-01	0.246	0	0
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	R-HSA-174178	5.715931e-01	0.243	0	0
Regulation of Homotypic Cell-Cell Adhesion	R-HSA-9759476	5.745612e-01	0.241	0	0
Thromboxane signalling through TP receptor	R-HSA-428930	5.777285e-01	0.238	0	0
SHC-mediated cascade:FGFR1	R-HSA-5654688	5.777285e-01	0.238	0	0
Neurodegenerative Diseases	R-HSA-8863678	5.777285e-01	0.238	0	0
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	R-HSA-8862803	5.777285e-01	0.238	0	0
Norepinephrine Neurotransmitter Release Cycle	R-HSA-181430	5.777285e-01	0.238	0	0
CD209 (DC-SIGN) signaling	R-HSA-5621575	5.777285e-01	0.238	0	0
Inositol phosphate metabolism	R-HSA-1483249	5.853450e-01	0.233	0	0
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	5.869097e-01	0.231	1	1
Signal amplification	R-HSA-392518	5.869097e-01	0.231	0	0
NOD1/2 Signaling Pathway	R-HSA-168638	5.869097e-01	0.231	0	0
Nuclear import of Rev protein	R-HSA-180746	5.869097e-01	0.231	0	0
CDK-mediated phosphorylation and removal of Cdc6	R-HSA-69017	5.872606e-01	0.231	0	0
SARS-CoV-2-host interactions	R-HSA-9705683	5.938632e-01	0.226	0	0
VLDL assembly	R-HSA-8866423	5.939187e-01	0.226	0	0
Chylomicron clearance	R-HSA-8964026	5.939187e-01	0.226	0	0
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	R-HSA-210746	5.939187e-01	0.226	0	0
Erythropoietin activates STAT5	R-HSA-9027283	5.939187e-01	0.226	0	0
Autointegration results in viral DNA circles	R-HSA-177539	5.939187e-01	0.226	0	0
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	5.939187e-01	0.226	0	0
Toxicity of botulinum toxin type F (botF)	R-HSA-5250981	5.939187e-01	0.226	0	0
Toxicity of botulinum toxin type D (botD)	R-HSA-5250955	5.939187e-01	0.226	0	0
Activation of NIMA Kinases NEK9, NEK6, NEK7	R-HSA-2980767	5.939187e-01	0.226	0	0
G2/M DNA replication checkpoint	R-HSA-69478	5.939187e-01	0.226	0	0
PTK6 promotes HIF1A stabilization	R-HSA-8857538	5.939187e-01	0.226	0	0
Integration of viral DNA into host genomic DNA	R-HSA-175567	5.939187e-01	0.226	0	0
CREB3 factors activate genes	R-HSA-8874211	5.939187e-01	0.226	0	0
Regulation of BACH1 activity	R-HSA-9708530	5.947337e-01	0.226	0	0
Class I peroxisomal membrane protein import	R-HSA-9603798	5.947337e-01	0.226	0	0
KSRP (KHSRP) binds and destabilizes mRNA	R-HSA-450604	5.947337e-01	0.226	0	0
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	5.947337e-01	0.226	0	0
Defective GALNT12 causes CRCS1	R-HSA-5083636	5.947337e-01	0.226	0	0
Defective GALNT3 causes HFTC	R-HSA-5083625	5.947337e-01	0.226	0	0
WNT5A-dependent internalization of FZD4	R-HSA-5099900	5.947337e-01	0.226	0	0
Prolonged ERK activation events	R-HSA-169893	5.947337e-01	0.226	0	0
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	R-HSA-399955	5.947337e-01	0.226	0	0
Caspase activation via Death Receptors in the presence of ligand	R-HSA-140534	5.947337e-01	0.226	0	0
Atorvastatin ADME	R-HSA-9754706	5.947337e-01	0.226	0	0
Negative regulation of FLT3	R-HSA-9706369	5.947337e-01	0.226	0	0
Receptor-type tyrosine-protein phosphatases	R-HSA-388844	5.947337e-01	0.226	0	0
Pre-NOTCH Expression and Processing	R-HSA-1912422	5.963127e-01	0.225	0	0
Polymerase switching on the C-strand of the telomere	R-HSA-174411	5.997747e-01	0.222	0	0
Long-term potentiation	R-HSA-9620244	5.997747e-01	0.222	0	0
Signaling by Interleukins	R-HSA-449147	6.014403e-01	0.221	0	0
Downstream signaling of activated FGFR1	R-HSA-5654687	6.057080e-01	0.218	0	0
Transferrin endocytosis and recycling	R-HSA-917977	6.057080e-01	0.218	0	0
Co-inhibition by PD-1	R-HSA-389948	6.079256e-01	0.216	0	0
RSV-host interactions	R-HSA-9833110	6.115013e-01	0.214	0	0
Dectin-1 mediated noncanonical NF-kB signaling	R-HSA-5607761	6.117521e-01	0.213	0	0
Potential therapeutics for SARS	R-HSA-9679191	6.127387e-01	0.213	0	0
Activated NOTCH1 Transmits Signal to the Nucleus	R-HSA-2122948	6.210503e-01	0.207	0	0
Signaling by EGFR in Cancer	R-HSA-1643713	6.210503e-01	0.207	0	0
Postmitotic nuclear pore complex (NPC) reformation	R-HSA-9615933	6.210503e-01	0.207	0	0
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	R-HSA-110373	6.210503e-01	0.207	0	0
Glutamate Neurotransmitter Release Cycle	R-HSA-210500	6.210503e-01	0.207	0	0
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	R-HSA-2892247	6.211396e-01	0.207	0	0
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	R-HSA-6804114	6.211396e-01	0.207	0	0
Disorders of Developmental Biology	R-HSA-9675151	6.211396e-01	0.207	0	0
G1/S-Specific Transcription	R-HSA-69205	6.239749e-01	0.205	0	0
Condensation of Prophase Chromosomes	R-HSA-2299718	6.279781e-01	0.202	0	0
Autodegradation of Cdh1 by Cdh1:APC/C	R-HSA-174084	6.279781e-01	0.202	0	0
TGFBR3 regulates TGF-beta signaling	R-HSA-9839389	6.326230e-01	0.199	0	0
Netrin mediated repulsion signals	R-HSA-418886	6.326230e-01	0.199	0	0
VLDL clearance	R-HSA-8964046	6.326230e-01	0.199	0	0
IFNG signaling activates MAPKs	R-HSA-9732724	6.326230e-01	0.199	0	0
SLBP independent Processing of Histone Pre-mRNAs	R-HSA-111367	6.326230e-01	0.199	0	0
SOS-mediated signalling	R-HSA-112412	6.326230e-01	0.199	0	0
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	R-HSA-9632974	6.326230e-01	0.199	0	0
Pre-NOTCH Processing in the Endoplasmic Reticulum	R-HSA-1912399	6.326230e-01	0.199	0	0
SHOC2 M1731 mutant abolishes MRAS complex function	R-HSA-9726840	6.326230e-01	0.199	0	0
LDL remodeling	R-HSA-8964041	6.326230e-01	0.199	0	0
Nef Mediated CD4 Down-regulation	R-HSA-167590	6.326230e-01	0.199	0	0
Cysteine formation from homocysteine	R-HSA-1614603	6.326230e-01	0.199	0	0
Microbial modulation of RIPK1-mediated regulated necrosis	R-HSA-9686347	6.326230e-01	0.199	0	0
Activated NTRK3 signals through PI3K	R-HSA-9603381	6.326230e-01	0.199	0	0
Activation of TRKA receptors	R-HSA-187015	6.326230e-01	0.199	0	0
Uptake and function of diphtheria toxin	R-HSA-5336415	6.326230e-01	0.199	0	0
Displacement of DNA glycosylase by APEX1	R-HSA-110357	6.326230e-01	0.199	0	0
Cell-Cell communication	R-HSA-1500931	6.360114e-01	0.197	0	0
Interferon alpha/beta signaling	R-HSA-909733	6.388029e-01	0.195	0	0
Telomere Maintenance	R-HSA-157579	6.393600e-01	0.194	0	0
Signaling by BMP	R-HSA-201451	6.415408e-01	0.193	0	0
CD28 dependent PI3K/Akt signaling	R-HSA-389357	6.415408e-01	0.193	0	0
Retrograde transport at the Trans-Golgi-Network	R-HSA-6811440	6.437868e-01	0.191	0	0
Defective C1GALT1C1 causes TNPS	R-HSA-5083632	6.461958e-01	0.190	0	0
Elevation of cytosolic Ca2+ levels	R-HSA-139853	6.461958e-01	0.190	0	0
Regulation of NPAS4 gene expression	R-HSA-9768759	6.461958e-01	0.190	0	0
Uptake and function of anthrax toxins	R-HSA-5210891	6.461958e-01	0.190	0	0
Signaling by WNT	R-HSA-195721	6.531177e-01	0.185	0	0
Cell junction organization	R-HSA-446728	6.577598e-01	0.182	0	0
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	6.583061e-01	0.182	0	0
SLC-mediated transport of inorganic anions	R-HSA-9958790	6.588596e-01	0.181	0	0
Rev-mediated nuclear export of HIV RNA	R-HSA-165054	6.588596e-01	0.181	0	0
Peroxisomal protein import	R-HSA-9033241	6.608213e-01	0.180	0	0
ROBO receptors bind AKAP5	R-HSA-9010642	6.676403e-01	0.175	0	0
Signaling by MRAS-complex mutants	R-HSA-9660537	6.676403e-01	0.175	0	0
Formation of annular gap junctions	R-HSA-196025	6.676403e-01	0.175	0	0
Regulation of NPAS4 mRNA translation	R-HSA-9768778	6.676403e-01	0.175	0	0
Gain-of-function MRAS complexes activate RAF signaling	R-HSA-9726842	6.676403e-01	0.175	0	0
Interleukin-23 signaling	R-HSA-9020933	6.676403e-01	0.175	0	0
Regulation by c-FLIP	R-HSA-3371378	6.676403e-01	0.175	0	0
FGFR1b ligand binding and activation	R-HSA-190370	6.676403e-01	0.175	0	0
Fructose biosynthesis	R-HSA-5652227	6.676403e-01	0.175	0	0
Dimerization of procaspase-8	R-HSA-69416	6.676403e-01	0.175	0	0
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	R-HSA-8849469	6.676403e-01	0.175	0	0
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	R-HSA-111453	6.676403e-01	0.175	0	0
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	R-HSA-442729	6.676403e-01	0.175	0	0
FGFR1 ligand binding and activation	R-HSA-190242	6.699197e-01	0.174	0	0
Depolymerization of the Nuclear Lamina	R-HSA-4419969	6.699197e-01	0.174	0	0
Cytosolic iron-sulfur cluster assembly	R-HSA-2564830	6.699197e-01	0.174	0	0
Nucleotide-like (purinergic) receptors	R-HSA-418038	6.699197e-01	0.174	0	0
Nephron development	R-HSA-9831926	6.699197e-01	0.174	0	0
Synaptic adhesion-like molecules	R-HSA-8849932	6.699197e-01	0.174	0	0
Apoptotic factor-mediated response	R-HSA-111471	6.699197e-01	0.174	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9679504	6.699197e-01	0.174	0	0
Degradation of CDH1	R-HSA-9766229	6.741144e-01	0.171	0	0
Metabolism of RNA	R-HSA-8953854	6.744185e-01	0.171	0	0
Kinesins	R-HSA-983189	6.745058e-01	0.171	0	0
Adherens junctions interactions	R-HSA-418990	6.750045e-01	0.171	0	0
Transcriptional and post-translational regulation of MITF-M expression and activity	R-HSA-9856649	6.758891e-01	0.170	0	0
Developmental Lineage of Mammary Gland Myoepithelial Cells	R-HSA-9927432	6.801378e-01	0.167	0	0
Downstream signaling of activated FGFR3	R-HSA-5654708	6.801378e-01	0.167	0	0
mRNA Capping	R-HSA-72086	6.801378e-01	0.167	0	0
Extra-nuclear estrogen signaling	R-HSA-9009391	6.828334e-01	0.166	0	0
Cell-cell junction organization	R-HSA-421270	6.863446e-01	0.163	0	0
Intra-Golgi and retrograde Golgi-to-ER traffic	R-HSA-6811442	6.897793e-01	0.161	0	0
Inhibition of DNA recombination at telomere	R-HSA-9670095	6.914881e-01	0.160	0	0
Interactions of Rev with host cellular proteins	R-HSA-177243	6.914881e-01	0.160	0	0
E2F mediated regulation of DNA replication	R-HSA-113510	6.923376e-01	0.160	0	0
Rap1 signalling	R-HSA-392517	6.923376e-01	0.160	0	0
Specification of the neural plate border	R-HSA-9834899	6.923376e-01	0.160	0	0
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	6.923376e-01	0.160	0	0
Maturation of nucleoprotein	R-HSA-9694631	6.923376e-01	0.160	0	0
Chromosome Maintenance	R-HSA-73886	6.978583e-01	0.156	0	0
Downstream signaling of activated FGFR4	R-HSA-5654716	6.982427e-01	0.156	0	0
MAPK family signaling cascades	R-HSA-5683057	6.989970e-01	0.156	0	0
Gap junction degradation	R-HSA-190873	6.993218e-01	0.155	0	0
CASP8 activity is inhibited	R-HSA-5218900	6.993218e-01	0.155	0	0
Hypusine synthesis from eIF5A-lysine	R-HSA-204626	6.993218e-01	0.155	0	0
Toxicity of botulinum toxin type A (botA)	R-HSA-5250968	6.993218e-01	0.155	0	0
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	6.993218e-01	0.155	0	0
MASTL Facilitates Mitotic Progression	R-HSA-2465910	6.993218e-01	0.155	0	0
Regulation of commissural axon pathfinding by SLIT and ROBO	R-HSA-428542	6.993218e-01	0.155	0	0
mRNA Editing	R-HSA-75072	6.993218e-01	0.155	0	0
MAPK1 (ERK2) activation	R-HSA-112411	6.993218e-01	0.155	0	0
Regulation of signaling by NODAL	R-HSA-1433617	6.993218e-01	0.155	0	0
AMPK inhibits chREBP transcriptional activation activity	R-HSA-163680	6.993218e-01	0.155	0	0
Regulation of NPAS4 gene transcription	R-HSA-9768777	6.993218e-01	0.155	0	0
Respiratory syncytial virus genome replication	R-HSA-9834752	6.993218e-01	0.155	0	0
NOTCH4 Activation and Transmission of Signal to the Nucleus	R-HSA-9013700	6.993218e-01	0.155	0	0
Regulated proteolysis of p75NTR	R-HSA-193692	6.993218e-01	0.155	0	0
Interleukin-1 processing	R-HSA-448706	6.993218e-01	0.155	0	0
Zinc influx into cells by the SLC39 gene family	R-HSA-442380	6.993218e-01	0.155	0	0
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.007919e-01	0.154	0	0
Transport of Ribonucleoproteins into the Host Nucleus	R-HSA-168271	7.069459e-01	0.151	0	0
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	R-HSA-9609523	7.134828e-01	0.147	0	0
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	7.134828e-01	0.147	0	0
Common Pathway of Fibrin Clot Formation	R-HSA-140875	7.134828e-01	0.147	0	0
Cargo concentration in the ER	R-HSA-5694530	7.155584e-01	0.145	0	0
Budding and maturation of HIV virion	R-HSA-162588	7.155584e-01	0.145	0	0
Negative regulators of DDX58/IFIH1 signaling	R-HSA-936440	7.155584e-01	0.145	0	0
Uptake and actions of bacterial toxins	R-HSA-5339562	7.162906e-01	0.145	0	0
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	R-HSA-9615017	7.218327e-01	0.142	0	0
Signaling by RAF1 mutants	R-HSA-9656223	7.218327e-01	0.142	0	0
Degradation of CRY and PER proteins	R-HSA-9932298	7.218327e-01	0.142	0	0
TP53 Regulates Transcription of Cell Death Genes	R-HSA-5633008	7.235383e-01	0.141	1	0
ISG15 antiviral mechanism	R-HSA-1169408	7.235383e-01	0.141	0	0
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	R-HSA-381426	7.238807e-01	0.140	0	0
TICAM1,TRAF6-dependent induction of TAK1 complex	R-HSA-9014325	7.279850e-01	0.138	0	0
Erythropoietin activates Phospholipase C gamma (PLCG)	R-HSA-9027277	7.279850e-01	0.138	0	0
Folding of actin by CCT/TriC	R-HSA-390450	7.279850e-01	0.138	0	0
PI3K/AKT activation	R-HSA-198203	7.279850e-01	0.138	0	0
Apoptosis induced DNA fragmentation	R-HSA-140342	7.279850e-01	0.138	0	0
Defective RIPK1-mediated regulated necrosis	R-HSA-9693928	7.279850e-01	0.138	0	0
Interleukin-27 signaling	R-HSA-9020956	7.279850e-01	0.138	0	0
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	R-HSA-428359	7.279850e-01	0.138	0	0
Receptor Mediated Mitophagy	R-HSA-8934903	7.279850e-01	0.138	0	0
MAPK3 (ERK1) activation	R-HSA-110056	7.279850e-01	0.138	0	0
Assembly and release of respiratory syncytial virus (RSV) virions	R-HSA-9820962	7.279850e-01	0.138	0	0
Tandem pore domain potassium channels	R-HSA-1296346	7.279850e-01	0.138	0	0
Josephin domain DUBs	R-HSA-5689877	7.279850e-01	0.138	0	0
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	7.279850e-01	0.138	0	0
B-WICH complex positively regulates rRNA expression	R-HSA-5250924	7.294541e-01	0.137	0	0
DNA Replication	R-HSA-69306	7.298116e-01	0.137	0	0
TP53 Regulates Metabolic Genes	R-HSA-5628897	7.329661e-01	0.135	0	0
PKA-mediated phosphorylation of CREB	R-HSA-111931	7.333943e-01	0.135	0	0
Basigin interactions	R-HSA-210991	7.333943e-01	0.135	0	0
MTOR signalling	R-HSA-165159	7.361510e-01	0.133	0	0
Signaling by BRAF and RAF1 fusions	R-HSA-6802952	7.374654e-01	0.132	0	0
SARS-CoV-2 modulates host translation machinery	R-HSA-9754678	7.421700e-01	0.129	0	0
Regulation of necroptotic cell death	R-HSA-5675482	7.478627e-01	0.126	0	0
Signaling by SCF-KIT	R-HSA-1433557	7.499057e-01	0.125	0	0
activated TAK1 mediates p38 MAPK activation	R-HSA-450302	7.521151e-01	0.124	0	0
Assembly Of The HIV Virion	R-HSA-175474	7.521151e-01	0.124	0	0
Mitochondrial calcium ion transport	R-HSA-8949215	7.521151e-01	0.124	0	0
Signaling by PDGFR in disease	R-HSA-9671555	7.521151e-01	0.124	0	0
Regulation of CDH11 mRNA translation by microRNAs	R-HSA-9759811	7.539173e-01	0.123	0	0
Synthesis of PIPs at the ER membrane	R-HSA-1483248	7.539173e-01	0.123	0	0
FGFRL1 modulation of FGFR1 signaling	R-HSA-5658623	7.539173e-01	0.123	0	0
vRNP Assembly	R-HSA-192905	7.539173e-01	0.123	0	0
InlA-mediated entry of Listeria monocytogenes into host cells	R-HSA-8876493	7.539173e-01	0.123	0	0
Synthesis of PI	R-HSA-1483226	7.539173e-01	0.123	0	0
Suppression of apoptosis	R-HSA-9635465	7.539173e-01	0.123	0	0
Prostanoid ligand receptors	R-HSA-391908	7.539173e-01	0.123	0	0
CD163 mediating an anti-inflammatory response	R-HSA-9662834	7.539173e-01	0.123	0	0
Interleukin-2 signaling	R-HSA-9020558	7.539173e-01	0.123	0	0
Dissolution of Fibrin Clot	R-HSA-75205	7.539173e-01	0.123	0	0
COPI-independent Golgi-to-ER retrograde traffic	R-HSA-6811436	7.544404e-01	0.122	0	0
Striated Muscle Contraction	R-HSA-390522	7.628791e-01	0.118	0	0
Association of TriC/CCT with target proteins during biosynthesis	R-HSA-390471	7.628791e-01	0.118	0	0
Effects of PIP2 hydrolysis	R-HSA-114508	7.628791e-01	0.118	0	0
EGR2 and SOX10-mediated initiation of Schwann cell myelination	R-HSA-9619665	7.628791e-01	0.118	0	0
Surfactant metabolism	R-HSA-5683826	7.631033e-01	0.117	0	0
Sensory processing of sound by outer hair cells of the cochlea	R-HSA-9662361	7.662689e-01	0.116	0	0
Respiratory Syncytial Virus Infection Pathway	R-HSA-9820952	7.666797e-01	0.115	0	0
Neddylation	R-HSA-8951664	7.670045e-01	0.115	0	0
Cellular response to starvation	R-HSA-9711097	7.672994e-01	0.115	0	0
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	R-HSA-6803205	7.696912e-01	0.114	0	0
LDL clearance	R-HSA-8964038	7.696912e-01	0.114	0	0
RAF-independent MAPK1/3 activation	R-HSA-112409	7.696912e-01	0.114	0	0
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	R-HSA-9857377	7.696912e-01	0.114	0	0
Cellular hexose transport	R-HSA-189200	7.696912e-01	0.114	0	0
Translation of Replicase and Assembly of the Replication Transcription Complex	R-HSA-9694676	7.696912e-01	0.114	0	0
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	R-HSA-8936459	7.708168e-01	0.113	0	0
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.757520e-01	0.110	0	0
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	7.757520e-01	0.110	0	0
p53-Independent G1/S DNA Damage Checkpoint	R-HSA-69613	7.757520e-01	0.110	0	0
NEP/NS2 Interacts with the Cellular Export Machinery	R-HSA-168333	7.757520e-01	0.110	0	0
Negative epigenetic regulation of rRNA expression	R-HSA-5250941	7.760375e-01	0.110	0	0
Signaling by MET	R-HSA-6806834	7.760375e-01	0.110	0	0
Transport to the Golgi and subsequent modification	R-HSA-948021	7.770145e-01	0.110	0	0
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	R-HSA-9843970	7.771610e-01	0.109	0	0
Mitophagy	R-HSA-5205647	7.771610e-01	0.109	0	0
Signaling by CSF1 (M-CSF) in myeloid cells	R-HSA-9680350	7.771610e-01	0.109	0	0
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	R-HSA-110328	7.771610e-01	0.109	0	0
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	7.773787e-01	0.109	0	0
Scavenging by Class H Receptors	R-HSA-3000497	7.773787e-01	0.109	0	0
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	R-HSA-3772470	7.773787e-01	0.109	0	0
Signaling by activated point mutants of FGFR1	R-HSA-1839122	7.773787e-01	0.109	0	0
Plasmalogen biosynthesis	R-HSA-75896	7.773787e-01	0.109	0	0
Inhibition of replication initiation of damaged DNA by RB1/E2F1	R-HSA-113501	7.773787e-01	0.109	0	0
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	7.773787e-01	0.109	0	0
Regulation of CDH1 Function	R-HSA-9764561	7.776598e-01	0.109	0	0
Synthesis of PA	R-HSA-1483166	7.776598e-01	0.109	0	0
Regulation of T cell activation by CD28 family	R-HSA-388841	7.826531e-01	0.106	0	0
Interleukin receptor SHC signaling	R-HSA-912526	7.861705e-01	0.104	0	0
Termination of O-glycan biosynthesis	R-HSA-977068	7.861705e-01	0.104	0	0
Growth hormone receptor signaling	R-HSA-982772	7.861705e-01	0.104	0	0
Synthesis of pyrophosphates in the cytosol	R-HSA-1855167	7.861705e-01	0.104	0	0
Mitochondrial mRNA modification	R-HSA-9937008	7.861705e-01	0.104	0	0
Interleukin-20 family signaling	R-HSA-8854691	7.861705e-01	0.104	0	0
Signaling downstream of RAS mutants	R-HSA-9649948	7.878614e-01	0.104	0	0
Signaling by moderate kinase activity BRAF mutants	R-HSA-6802946	7.878614e-01	0.104	0	0
Paradoxical activation of RAF signaling by kinase inactive BRAF	R-HSA-6802955	7.878614e-01	0.104	0	0
Signaling by RAS mutants	R-HSA-6802949	7.878614e-01	0.104	0	0
Export of Viral Ribonucleoproteins from Nucleus	R-HSA-168274	7.878614e-01	0.104	0	0
C-type lectin receptors (CLRs)	R-HSA-5621481	7.880531e-01	0.103	0	0
SCF-beta-TrCP mediated degradation of Emi1	R-HSA-174113	7.907275e-01	0.102	0	0
Signalling to ERKs	R-HSA-187687	7.907275e-01	0.102	0	0
COPII-mediated vesicle transport	R-HSA-204005	7.912294e-01	0.102	0	0
Senescence-Associated Secretory Phenotype (SASP)	R-HSA-2559582	7.948488e-01	0.100	0	0
PI Metabolism	R-HSA-1483255	7.954870e-01	0.099	0	0
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	R-HSA-9027276	7.986046e-01	0.098	0	0
Constitutive Signaling by NOTCH1 HD Domain Mutants	R-HSA-2691232	7.986046e-01	0.098	0	0
Signaling by NOTCH1 HD Domain Mutants in Cancer	R-HSA-2691230	7.986046e-01	0.098	0	0
Interleukin-35 Signalling	R-HSA-8984722	7.986046e-01	0.098	0	0
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	7.986046e-01	0.098	0	0
VLDLR internalisation and degradation	R-HSA-8866427	7.986046e-01	0.098	0	0
Regulation of IFNG signaling	R-HSA-877312	7.986046e-01	0.098	0	0
Serotonin clearance from the synaptic cleft	R-HSA-380615	7.986046e-01	0.098	0	0
Interleukin-15 signaling	R-HSA-8983432	7.986046e-01	0.098	0	0
Polymerase switching	R-HSA-69091	7.986046e-01	0.098	0	0
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	R-HSA-9820865	7.986046e-01	0.098	0	0
Leading Strand Synthesis	R-HSA-69109	7.986046e-01	0.098	0	0
Synthesis of GDP-mannose	R-HSA-446205	7.986046e-01	0.098	0	0
Loss of function of MECP2 in Rett syndrome	R-HSA-9005891	7.986046e-01	0.098	0	0
Disorders of Nervous System Development	R-HSA-9697154	7.986046e-01	0.098	0	0
Pervasive developmental disorders	R-HSA-9005895	7.986046e-01	0.098	0	0
Reversal of alkylation damage by DNA dioxygenases	R-HSA-73943	7.986046e-01	0.098	0	0
Vesicle-mediated transport	R-HSA-5653656	7.993337e-01	0.097	0	0
Positive epigenetic regulation of rRNA expression	R-HSA-5250913	8.009000e-01	0.096	0	0
NoRC negatively regulates rRNA expression	R-HSA-427413	8.009000e-01	0.096	0	0
Formation of tubulin folding intermediates by CCT/TriC	R-HSA-389960	8.016026e-01	0.096	0	0
Interleukin-6 family signaling	R-HSA-6783589	8.016026e-01	0.096	0	0
Mitochondrial RNA degradation	R-HSA-9836573	8.016026e-01	0.096	0	0
Assembly of active LPL and LIPC lipase complexes	R-HSA-8963889	8.016026e-01	0.096	0	0
RET signaling	R-HSA-8853659	8.035995e-01	0.095	0	0
Golgi-to-ER retrograde transport	R-HSA-8856688	8.039495e-01	0.095	0	0
Assembly of the pre-replicative complex	R-HSA-68867	8.073559e-01	0.093	0	0
Cellular responses to mechanical stimuli	R-HSA-9855142	8.081521e-01	0.093	0	0
Cyclin A:Cdk2-associated events at S phase entry	R-HSA-69656	8.102201e-01	0.091	0	0
Plasma lipoprotein remodeling	R-HSA-8963899	8.105063e-01	0.091	0	0
Response of endothelial cells to shear stress	R-HSA-9860931	8.113044e-01	0.091	0	0
RUNX1 regulates transcription of genes involved in differentiation of HSCs	R-HSA-8939236	8.124392e-01	0.090	0	0
Signaling by high-kinase activity BRAF mutants	R-HSA-6802948	8.157989e-01	0.088	0	0
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	R-HSA-9762114	8.157989e-01	0.088	0	0
Tight junction interactions	R-HSA-420029	8.160371e-01	0.088	0	0
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	8.160371e-01	0.088	0	0
PDH complex synthesizes acetyl-CoA from PYR	R-HSA-9861559	8.178079e-01	0.087	0	0
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	R-HSA-9029558	8.178079e-01	0.087	0	0
IL-6-type cytokine receptor ligand interactions	R-HSA-6788467	8.178079e-01	0.087	0	0
FGFR4 ligand binding and activation	R-HSA-190322	8.178079e-01	0.087	0	0
Frs2-mediated activation	R-HSA-170968	8.178079e-01	0.087	0	0
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.178079e-01	0.087	0	0
Signaling by activated point mutants of FGFR3	R-HSA-1839130	8.178079e-01	0.087	0	0
FGFR3 mutant receptor activation	R-HSA-2033514	8.178079e-01	0.087	0	0
CREB1 phosphorylation through the activation of Adenylate Cyclase	R-HSA-442720	8.178079e-01	0.087	0	0
rRNA modification in the mitochondrion	R-HSA-6793080	8.178079e-01	0.087	0	0
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	R-HSA-8877330	8.178079e-01	0.087	0	0
Maturation of nucleoprotein	R-HSA-9683610	8.178079e-01	0.087	0	0
Replication of the SARS-CoV-1 genome	R-HSA-9682706	8.178079e-01	0.087	0	0
Regulation of RUNX2 expression and activity	R-HSA-8939902	8.189730e-01	0.087	0	0
Oncogenic MAPK signaling	R-HSA-6802957	8.207861e-01	0.086	0	0
RIPK1-mediated regulated necrosis	R-HSA-5213460	8.273485e-01	0.082	0	0
Regulation of RUNX1 Expression and Activity	R-HSA-8934593	8.295240e-01	0.081	0	0
TRP channels	R-HSA-3295583	8.295240e-01	0.081	0	0
Synthesis of IP2, IP, and Ins in the cytosol	R-HSA-1855183	8.295240e-01	0.081	0	0
Sphingolipid catabolism	R-HSA-9845614	8.295240e-01	0.081	0	0
Synthesis of PIPs at the Golgi membrane	R-HSA-1660514	8.295240e-01	0.081	0	0
SARS-CoV-1-host interactions	R-HSA-9692914	8.332719e-01	0.079	0	0
FGFR3c ligand binding and activation	R-HSA-190372	8.351811e-01	0.078	0	0
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	8.351811e-01	0.078	0	0
Retrograde neurotrophin signalling	R-HSA-177504	8.351811e-01	0.078	0	0
ERBB2 Activates PTK6 Signaling	R-HSA-8847993	8.351811e-01	0.078	0	0
HDL assembly	R-HSA-8963896	8.351811e-01	0.078	0	0
Signal regulatory protein family interactions	R-HSA-391160	8.351811e-01	0.078	0	0
CRMPs in Sema3A signaling	R-HSA-399956	8.351811e-01	0.078	0	0
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	R-HSA-975163	8.351811e-01	0.078	0	0
Formation of the active cofactor, UDP-glucuronate	R-HSA-173599	8.351811e-01	0.078	0	0
P2Y receptors	R-HSA-417957	8.351811e-01	0.078	0	0
Malate-aspartate shuttle	R-HSA-9856872	8.351811e-01	0.078	0	0
NRIF signals cell death from the nucleus	R-HSA-205043	8.351811e-01	0.078	0	0
Regulation of KIT signaling	R-HSA-1433559	8.351811e-01	0.078	0	0
Zinc transporters	R-HSA-435354	8.351811e-01	0.078	0	0
SARS-CoV-1 Genome Replication and Transcription	R-HSA-9679514	8.351811e-01	0.078	0	0
COPI-dependent Golgi-to-ER retrograde traffic	R-HSA-6811434	8.380518e-01	0.077	0	0
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	R-HSA-9725554	8.382720e-01	0.077	0	0
GSK3B-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929356	8.382720e-01	0.077	0	0
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	8.383625e-01	0.077	0	0
Cristae formation	R-HSA-8949613	8.421126e-01	0.075	0	0
Packaging Of Telomere Ends	R-HSA-171306	8.421126e-01	0.075	0	0
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	R-HSA-8866652	8.421126e-01	0.075	0	0
Signaling by NTRK2 (TRKB)	R-HSA-9006115	8.421126e-01	0.075	0	0
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	R-HSA-193807	8.421126e-01	0.075	0	0
Post NMDA receptor activation events	R-HSA-438064	8.440888e-01	0.074	0	0
RNA Polymerase I Promoter Clearance	R-HSA-73854	8.441125e-01	0.074	0	0
Regulation of RUNX3 expression and activity	R-HSA-8941858	8.485931e-01	0.071	0	0
Negative regulation of NOTCH4 signaling	R-HSA-9604323	8.485931e-01	0.071	0	0
Nuclear signaling by ERBB4	R-HSA-1251985	8.485931e-01	0.071	0	0
RNA Polymerase I Promoter Escape	R-HSA-73772	8.498592e-01	0.071	0	0
Orc1 removal from chromatin	R-HSA-68949	8.498592e-01	0.071	0	0
SARS-CoV-1 activates/modulates innate immune responses	R-HSA-9692916	8.498592e-01	0.071	0	0
DCC mediated attractive signaling	R-HSA-418885	8.508986e-01	0.070	0	0
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	R-HSA-8948700	8.508986e-01	0.070	0	0
TRAF6-mediated induction of TAK1 complex within TLR4 complex	R-HSA-937072	8.508986e-01	0.070	0	0
SHC1 events in EGFR signaling	R-HSA-180336	8.508986e-01	0.070	0	0
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	8.508986e-01	0.070	0	0
ERBB2 Regulates Cell Motility	R-HSA-6785631	8.508986e-01	0.070	0	0
FGFR3 ligand binding and activation	R-HSA-190239	8.508986e-01	0.070	0	0
Lysosphingolipid and LPA receptors	R-HSA-419408	8.508986e-01	0.070	0	0
FASTK family proteins regulate processing and stability of mitochondrial RNAs	R-HSA-9837092	8.508986e-01	0.070	0	0
Other semaphorin interactions	R-HSA-416700	8.508986e-01	0.070	0	0
Protein methylation	R-HSA-8876725	8.508986e-01	0.070	0	0
Cell-extracellular matrix interactions	R-HSA-446353	8.508986e-01	0.070	0	0
DNA Damage Reversal	R-HSA-73942	8.508986e-01	0.070	0	0
Telomere Extension By Telomerase	R-HSA-171319	8.538517e-01	0.069	0	0
PINK1-PRKN Mediated Mitophagy	R-HSA-5205685	8.538517e-01	0.069	0	0
Activation of kainate receptors upon glutamate binding	R-HSA-451326	8.538517e-01	0.069	0	0
Pyroptosis	R-HSA-5620971	8.538517e-01	0.069	0	0
Cellular response to hypoxia	R-HSA-1234174	8.538732e-01	0.069	0	0
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	8.583360e-01	0.066	0	0
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.583360e-01	0.066	0	0
PCP/CE pathway	R-HSA-4086400	8.591205e-01	0.066	0	0
RNA Polymerase I Transcription	R-HSA-73864	8.591205e-01	0.066	0	0
Signaling by Erythropoietin	R-HSA-9006335	8.647887e-01	0.063	0	0
DARPP-32 events	R-HSA-180024	8.647887e-01	0.063	0	0
Signaling by CSF3 (G-CSF)	R-HSA-9674555	8.647887e-01	0.063	0	0
Endosomal Sorting Complex Required For Transport (ESCRT)	R-HSA-917729	8.647887e-01	0.063	0	0
Downstream TCR signaling	R-HSA-202424	8.648971e-01	0.063	0	0
Base Excision Repair	R-HSA-73884	8.648971e-01	0.063	0	0
Phase 4 - resting membrane potential	R-HSA-5576886	8.651181e-01	0.063	0	0
Differentiation of T cells	R-HSA-9945266	8.651181e-01	0.063	0	0
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	R-HSA-9942503	8.651181e-01	0.063	0	0
Activation of SMO	R-HSA-5635838	8.651181e-01	0.063	0	0
Attachment and Entry	R-HSA-9678110	8.651181e-01	0.063	0	0
Sensory processing of sound	R-HSA-9659379	8.661659e-01	0.062	0	0
GLI3 is processed to GLI3R by the proteasome	R-HSA-5610785	8.675249e-01	0.062	0	0
MAP2K and MAPK activation	R-HSA-5674135	8.675249e-01	0.062	0	0
Degradation of GLI1 by the proteasome	R-HSA-5610780	8.675249e-01	0.062	0	0
HDACs deacetylate histones	R-HSA-3214815	8.746283e-01	0.058	0	0
DAP12 signaling	R-HSA-2424491	8.749698e-01	0.058	0	0
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	R-HSA-9927418	8.761839e-01	0.057	0	0
Interleukin-3, Interleukin-5 and GM-CSF signaling	R-HSA-512988	8.761839e-01	0.057	0	0
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	R-HSA-381676	8.761839e-01	0.057	0	0
Cleavage of the damaged pyrimidine	R-HSA-110329	8.761839e-01	0.057	0	0
Depyrimidination	R-HSA-73928	8.761839e-01	0.057	0	0
Regulated Necrosis	R-HSA-5218859	8.762093e-01	0.057	0	0
Sensory processing of sound by inner hair cells of the cochlea	R-HSA-9662360	8.762093e-01	0.057	0	0
Activation of NMDA receptors and postsynaptic events	R-HSA-442755	8.767060e-01	0.057	0	0
MHC class II antigen presentation	R-HSA-2132295	8.774300e-01	0.057	0	0
G beta:gamma signalling through CDC42	R-HSA-8964616	8.779823e-01	0.057	0	0
SHC1 events in ERBB4 signaling	R-HSA-1250347	8.779823e-01	0.057	0	0
Scavenging by Class B Receptors	R-HSA-3000471	8.779823e-01	0.057	0	0
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	R-HSA-975110	8.779823e-01	0.057	0	0
Galactose catabolism	R-HSA-70370	8.779823e-01	0.057	0	0
Biosynthesis of maresin-like SPMs	R-HSA-9027307	8.779823e-01	0.057	0	0
RAF/MAP kinase cascade	R-HSA-5673001	8.812071e-01	0.055	0	0
Ion homeostasis	R-HSA-5578775	8.820610e-01	0.055	0	0
Developmental Lineage of Pancreatic Ductal Cells	R-HSA-9925563	8.829797e-01	0.054	0	0
EPH-Ephrin signaling	R-HSA-2682334	8.833715e-01	0.054	0	0
Hh mutants abrogate ligand secretion	R-HSA-5387390	8.843367e-01	0.053	0	0
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	R-HSA-389958	8.844397e-01	0.053	0	0
Downstream signal transduction	R-HSA-186763	8.844397e-01	0.053	0	0
Cyclin E associated events during G1/S transition	R-HSA-69202	8.894307e-01	0.051	0	0
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	8.896202e-01	0.051	0	0
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	R-HSA-164938	8.896202e-01	0.051	0	0
Regulation of FZD by ubiquitination	R-HSA-4641263	8.896202e-01	0.051	0	0
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	R-HSA-190840	8.896202e-01	0.051	0	0
PI3K events in ERBB2 signaling	R-HSA-1963642	8.896202e-01	0.051	0	0
Replication of the SARS-CoV-2 genome	R-HSA-9694686	8.896202e-01	0.051	0	0
Netrin-1 signaling	R-HSA-373752	8.920070e-01	0.050	0	0
Recognition and association of DNA glycosylase with site containing an affected purine	R-HSA-110330	8.932413e-01	0.049	0	0
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	8.944766e-01	0.048	0	0
Hedgehog 'on' state	R-HSA-5632684	8.955733e-01	0.048	0	0
Early SARS-CoV-2 Infection Events	R-HSA-9772572	8.957827e-01	0.048	0	0
Beta-catenin independent WNT signaling	R-HSA-3858494	8.972165e-01	0.047	0	0
Somitogenesis	R-HSA-9824272	8.992179e-01	0.046	0	0
DAG and IP3 signaling	R-HSA-1489509	8.992179e-01	0.046	0	0
Platelet sensitization by LDL	R-HSA-432142	9.001488e-01	0.046	0	0
Transport of connexons to the plasma membrane	R-HSA-190872	9.001488e-01	0.046	0	0
Trafficking of GluR2-containing AMPA receptors	R-HSA-416993	9.001488e-01	0.046	0	0
PKA activation	R-HSA-163615	9.001488e-01	0.046	0	0
Vitamin D (calciferol) metabolism	R-HSA-196791	9.001488e-01	0.046	0	0
Organic anion transport by SLC5/17/25 transporters	R-HSA-428643	9.001488e-01	0.046	0	0
Tie2 Signaling	R-HSA-210993	9.001488e-01	0.046	0	0
Post-translational protein modification	R-HSA-597592	9.005460e-01	0.045	0	0
Sealing of the nuclear envelope (NE) by ESCRT-III	R-HSA-9668328	9.014160e-01	0.045	0	0
Recycling of bile acids and salts	R-HSA-159418	9.014160e-01	0.045	0	0
Developmental Lineages of the Mammary Gland	R-HSA-9924644	9.014183e-01	0.045	0	0
Transcriptional regulation by small RNAs	R-HSA-5578749	9.014183e-01	0.045	0	0
L1CAM interactions	R-HSA-373760	9.017902e-01	0.045	0	0
MAPK1/MAPK3 signaling	R-HSA-5684996	9.037220e-01	0.044	0	0
Purinergic signaling in leishmaniasis infection	R-HSA-9660826	9.059917e-01	0.043	0	0
Cell recruitment (pro-inflammatory response)	R-HSA-9664424	9.059917e-01	0.043	0	0
Translocation of SLC2A4 (GLUT4) to the plasma membrane	R-HSA-1445148	9.069766e-01	0.042	0	0
Ca2+ pathway	R-HSA-4086398	9.069766e-01	0.042	0	0
Vpu mediated degradation of CD4	R-HSA-180534	9.090033e-01	0.041	0	0
Acyl chain remodelling of PC	R-HSA-1482788	9.090033e-01	0.041	0	0
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	R-HSA-9768727	9.090033e-01	0.041	0	0
Pre-NOTCH Processing in Golgi	R-HSA-1912420	9.096736e-01	0.041	0	0
Regulation of signaling by CBL	R-HSA-912631	9.096736e-01	0.041	0	0
PI-3K cascade:FGFR3	R-HSA-5654710	9.096736e-01	0.041	0	0
Other interleukin signaling	R-HSA-449836	9.096736e-01	0.041	0	0
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	R-HSA-9856532	9.096736e-01	0.041	0	0
HDL remodeling	R-HSA-8964058	9.096736e-01	0.041	0	0
SARS-CoV-2 Genome Replication and Transcription	R-HSA-9694682	9.096736e-01	0.041	0	0
Developmental Cell Lineages of the Integumentary System	R-HSA-9734779	9.118600e-01	0.040	0	0
Signaling by ERBB4	R-HSA-1236394	9.122591e-01	0.040	0	0
ROS and RNS production in phagocytes	R-HSA-1222556	9.122591e-01	0.040	0	0
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	9.123507e-01	0.040	0	0
Viral Messenger RNA Synthesis	R-HSA-168325	9.137318e-01	0.039	0	0
Developmental Lineage of Mammary Gland Alveolar Cells	R-HSA-9927426	9.160407e-01	0.038	0	0
RAF activation	R-HSA-5673000	9.160407e-01	0.038	0	0
Regulation of TLR by endogenous ligand	R-HSA-5686938	9.160407e-01	0.038	0	0
SARS-CoV-1 Infection	R-HSA-9678108	9.177650e-01	0.037	0	0
Regulation of PD-L1(CD274) translation	R-HSA-9909620	9.182904e-01	0.037	0	0
Formation of ATP by chemiosmotic coupling	R-HSA-163210	9.182904e-01	0.037	0	0
PI-3K cascade:FGFR4	R-HSA-5654720	9.182904e-01	0.037	0	0
Post-chaperonin tubulin folding pathway	R-HSA-389977	9.182904e-01	0.037	0	0
Protein hydroxylation	R-HSA-9629569	9.182904e-01	0.037	0	0
Wax and plasmalogen biosynthesis	R-HSA-8848584	9.182904e-01	0.037	0	0
VxPx cargo-targeting to cilium	R-HSA-5620916	9.182904e-01	0.037	0	0
Pregnenolone biosynthesis	R-HSA-196108	9.182904e-01	0.037	0	0
Eicosanoid ligand-binding receptors	R-HSA-391903	9.182904e-01	0.037	0	0
Glycogen synthesis	R-HSA-3322077	9.182904e-01	0.037	0	0
Intraflagellar transport	R-HSA-5620924	9.183160e-01	0.037	0	0
GPER1 signaling	R-HSA-9634597	9.183160e-01	0.037	0	0
Nuclear events stimulated by ALK signaling in cancer	R-HSA-9725371	9.183160e-01	0.037	0	0
Co-stimulation by CD28	R-HSA-389356	9.183160e-01	0.037	0	0
The role of GTSE1 in G2/M progression after G2 checkpoint	R-HSA-8852276	9.190714e-01	0.037	0	0
Signaling by PDGF	R-HSA-186797	9.190714e-01	0.037	0	0
TCR signaling	R-HSA-202403	9.201802e-01	0.036	0	0
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	R-HSA-8854050	9.225641e-01	0.035	0	0
SARS-CoV-2 Infection	R-HSA-9694516	9.243411e-01	0.034	0	0
ADP signalling through P2Y purinoceptor 12	R-HSA-392170	9.260857e-01	0.033	0	0
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.260857e-01	0.033	0	0
Signalling to RAS	R-HSA-167044	9.260857e-01	0.033	0	0
Regulation of MITF-M-dependent genes involved in apoptosis	R-HSA-9824594	9.260857e-01	0.033	0	0
NOTCH2 Activation and Transmission of Signal to the Nucleus	R-HSA-2979096	9.260857e-01	0.033	0	0
Synthesis, secretion, and deacylation of Ghrelin	R-HSA-422085	9.260857e-01	0.033	0	0
Vitamin C (ascorbate) metabolism	R-HSA-196836	9.260857e-01	0.033	0	0
Nonsense-Mediated Decay (NMD)	R-HSA-927802	9.278151e-01	0.033	0	0
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	9.278151e-01	0.033	0	0
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	9.286076e-01	0.032	0	0
Calmodulin induced events	R-HSA-111933	9.286076e-01	0.032	0	0
CaM pathway	R-HSA-111997	9.286076e-01	0.032	0	0
Developmental Biology	R-HSA-1266738	9.326319e-01	0.030	0	0
Host Interactions of HIV factors	R-HSA-162909	9.328932e-01	0.030	0	0
FRS-mediated FGFR3 signaling	R-HSA-5654706	9.331376e-01	0.030	0	0
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.331376e-01	0.030	0	0
Inactivation of CSF3 (G-CSF) signaling	R-HSA-9705462	9.331376e-01	0.030	0	0
Glutathione synthesis and recycling	R-HSA-174403	9.331376e-01	0.030	0	0
Attachment and Entry	R-HSA-9694614	9.331376e-01	0.030	0	0
Hedgehog ligand biogenesis	R-HSA-5358346	9.340540e-01	0.030	0	0
Degradation of AXIN	R-HSA-4641257	9.342032e-01	0.030	0	0
Voltage gated Potassium channels	R-HSA-1296072	9.342032e-01	0.030	0	0
Cleavage of the damaged purine	R-HSA-110331	9.342032e-01	0.030	0	0
Depurination	R-HSA-73927	9.393815e-01	0.027	0	0
FRS-mediated FGFR4 signaling	R-HSA-5654712	9.395172e-01	0.027	0	0
Developmental Lineage of Mammary Stem Cells	R-HSA-9938206	9.395172e-01	0.027	0	0
PI-3K cascade:FGFR1	R-HSA-5654689	9.395172e-01	0.027	0	0
Regulation of IFNA/IFNB signaling	R-HSA-912694	9.395172e-01	0.027	0	0
FGFR2 alternative splicing	R-HSA-6803529	9.395172e-01	0.027	0	0
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	R-HSA-9670439	9.395172e-01	0.027	0	0
Neurotoxicity of clostridium toxins	R-HSA-168799	9.395172e-01	0.027	0	0
WNT ligand biogenesis and trafficking	R-HSA-3238698	9.395172e-01	0.027	0	0
mTORC1-mediated signalling	R-HSA-166208	9.395172e-01	0.027	0	0
Signaling by KIT in disease	R-HSA-9669938	9.395172e-01	0.027	0	0
Fructose metabolism	R-HSA-5652084	9.395172e-01	0.027	0	0
NOTCH3 Activation and Transmission of Signal to the Nucleus	R-HSA-9013507	9.395172e-01	0.027	0	0
Cholesterol biosynthesis via lathosterol	R-HSA-6807062	9.395172e-01	0.027	0	0
Response of EIF2AK4 (GCN2) to amino acid deficiency	R-HSA-9633012	9.407612e-01	0.027	0	0
Plasma lipoprotein assembly, remodeling, and clearance	R-HSA-174824	9.410410e-01	0.026	0	0
Kidney development	R-HSA-9830369	9.415680e-01	0.026	0	0
Golgi Associated Vesicle Biogenesis	R-HSA-432722	9.429384e-01	0.026	0	0
Smooth Muscle Contraction	R-HSA-445355	9.429384e-01	0.026	0	0
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	R-HSA-381771	9.441710e-01	0.025	0	0
Plasma lipoprotein clearance	R-HSA-8964043	9.441710e-01	0.025	0	0
Prefoldin mediated transfer of substrate to CCT/TriC	R-HSA-389957	9.452884e-01	0.024	0	0
The role of Nef in HIV-1 replication and disease pathogenesis	R-HSA-164952	9.452884e-01	0.024	0	0
ABC transporters in lipid homeostasis	R-HSA-1369062	9.452884e-01	0.024	0	0
Biosynthesis of maresins	R-HSA-9018682	9.452884e-01	0.024	0	0
Base-Excision Repair, AP Site Formation	R-HSA-73929	9.469516e-01	0.024	0	0
Interferon Signaling	R-HSA-913531	9.482026e-01	0.023	0	0
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	R-HSA-427389	9.485988e-01	0.023	0	0
Interleukin-2 family signaling	R-HSA-451927	9.485988e-01	0.023	0	0
Glycogen metabolism	R-HSA-8982491	9.485988e-01	0.023	0	0
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	9.490816e-01	0.023	0	0
Complex III assembly	R-HSA-9865881	9.505092e-01	0.022	0	0
Replacement of protamines by nucleosomes in the male pronucleus	R-HSA-9821993	9.505092e-01	0.022	0	0
Hh mutants are degraded by ERAD	R-HSA-5362768	9.526903e-01	0.021	0	0
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.527057e-01	0.021	0	0
FRS-mediated FGFR1 signaling	R-HSA-5654693	9.552321e-01	0.020	0	0
Acyl chain remodelling of PS	R-HSA-1482801	9.552321e-01	0.020	0	0
Hyaluronan degradation	R-HSA-2160916	9.552321e-01	0.020	0	0
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.552321e-01	0.020	0	0
PIWI-interacting RNA (piRNA) biogenesis	R-HSA-5601884	9.552321e-01	0.020	0	0
Diseases associated with O-glycosylation of proteins	R-HSA-3906995	9.552844e-01	0.020	0	0
Cargo trafficking to the periciliary membrane	R-HSA-5620920	9.552844e-01	0.020	0	0
Scavenging by Class A Receptors	R-HSA-3000480	9.564694e-01	0.019	0	0
Degradation of GLI2 by the proteasome	R-HSA-5610783	9.564694e-01	0.019	0	0
Negative regulation of MAPK pathway	R-HSA-5675221	9.564694e-01	0.019	0	0
Cardiac conduction	R-HSA-5576891	9.573202e-01	0.019	0	0
Cytokine Signaling in Immune system	R-HSA-1280215	9.575063e-01	0.019	0	0
Signaling by ROBO receptors	R-HSA-376176	9.576172e-01	0.019	0	0
Incretin synthesis, secretion, and inactivation	R-HSA-400508	9.599583e-01	0.018	0	0
Ca-dependent events	R-HSA-111996	9.599583e-01	0.018	0	0
Signaling by FGFR3 in disease	R-HSA-5655332	9.633695e-01	0.016	0	0
ER Quality Control Compartment (ERQC)	R-HSA-901032	9.633695e-01	0.016	0	0
Insulin processing	R-HSA-264876	9.633695e-01	0.016	0	0
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	R-HSA-6811558	9.636166e-01	0.016	0	0
tRNA processing	R-HSA-72306	9.647810e-01	0.016	0	0
Diseases of programmed cell death	R-HSA-9645723	9.651503e-01	0.015	0	0
SARS-CoV Infections	R-HSA-9679506	9.652415e-01	0.015	0	0
Hedgehog 'off' state	R-HSA-5610787	9.653531e-01	0.015	0	0
Iron uptake and transport	R-HSA-917937	9.659744e-01	0.015	0	0
RAB geranylgeranylation	R-HSA-8873719	9.660063e-01	0.015	0	0
SCF(Skp2)-mediated degradation of p27/p21	R-HSA-187577	9.661482e-01	0.015	0	0
DAP12 interactions	R-HSA-2172127	9.661482e-01	0.015	0	0
Gap junction trafficking	R-HSA-190828	9.661482e-01	0.015	0	0
Proteasome assembly	R-HSA-9907900	9.661482e-01	0.015	0	0
Phase 0 - rapid depolarisation	R-HSA-5576892	9.668657e-01	0.015	0	0
Activation of AMPK downstream of NMDARs	R-HSA-9619483	9.668657e-01	0.015	0	0
Iron assimilation using enterobactin	R-HSA-9638334	9.668657e-01	0.015	0	0
Pyrimidine salvage	R-HSA-73614	9.668657e-01	0.015	0	0
Prednisone ADME	R-HSA-9757110	9.668657e-01	0.015	0	0
ER-Phagosome pathway	R-HSA-1236974	9.673226e-01	0.014	0	0
Endogenous sterols	R-HSA-211976	9.684732e-01	0.014	0	0
Nucleosome assembly	R-HSA-774815	9.688871e-01	0.014	0	0
Deposition of new CENPA-containing nucleosomes at the centromere	R-HSA-606279	9.688871e-01	0.014	0	0
Asymmetric localization of PCP proteins	R-HSA-4608870	9.688871e-01	0.014	0	0
Defective CFTR causes cystic fibrosis	R-HSA-5678895	9.688871e-01	0.014	0	0
Glucagon-type ligand receptors	R-HSA-420092	9.700285e-01	0.013	0	0
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.700285e-01	0.013	0	0
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	9.700285e-01	0.013	0	0
mRNA Splicing - Minor Pathway	R-HSA-72165	9.714118e-01	0.013	0	0
Regulation of pyruvate metabolism	R-HSA-9861718	9.714118e-01	0.013	0	0
Signaling by Hedgehog	R-HSA-5358351	9.720118e-01	0.012	0	0
ABC transporter disorders	R-HSA-5619084	9.723743e-01	0.012	0	0
Muscle contraction	R-HSA-397014	9.726852e-01	0.012	0	0
GABA synthesis, release, reuptake and degradation	R-HSA-888590	9.728895e-01	0.012	0	0
Neurotransmitter clearance	R-HSA-112311	9.728895e-01	0.012	0	0
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.728895e-01	0.012	0	0
Recycling pathway of L1	R-HSA-437239	9.737382e-01	0.012	0	0
Respiratory syncytial virus (RSV) attachment and entry	R-HSA-9820960	9.754776e-01	0.011	0	0
Regulation of activated PAK-2p34 by proteasome mediated degradation	R-HSA-211733	9.754776e-01	0.011	0	0
Molecules associated with elastic fibres	R-HSA-2129379	9.754776e-01	0.011	0	0
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	9.756517e-01	0.011	0	0
Protein localization	R-HSA-9609507	9.759788e-01	0.011	0	0
Axon guidance	R-HSA-422475	9.761074e-01	0.011	0	0
Platelet homeostasis	R-HSA-418346	9.774883e-01	0.010	0	0
Regulation of ornithine decarboxylase (ODC)	R-HSA-350562	9.778187e-01	0.010	0	0
Gap junction trafficking and regulation	R-HSA-157858	9.778544e-01	0.010	0	0
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	R-HSA-532668	9.778544e-01	0.010	0	0
Nervous system development	R-HSA-9675108	9.780390e-01	0.010	0	0
Gene Silencing by RNA	R-HSA-211000	9.788577e-01	0.009	0	0
Regulation of RAS by GAPs	R-HSA-5658442	9.796709e-01	0.009	0	0
Defective B3GALTL causes PpS	R-HSA-5083635	9.799365e-01	0.009	0	0
G-protein beta:gamma signalling	R-HSA-397795	9.799365e-01	0.009	0	0
Stimuli-sensing channels	R-HSA-2672351	9.801494e-01	0.009	0	0
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	R-HSA-1234176	9.813426e-01	0.008	0	0
HCMV Early Events	R-HSA-9609690	9.814843e-01	0.008	0	0
Glucagon signaling in metabolic regulation	R-HSA-163359	9.818522e-01	0.008	0	0
Miscellaneous transport and binding events	R-HSA-5223345	9.818522e-01	0.008	0	0
Heme degradation	R-HSA-189483	9.818522e-01	0.008	0	0
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	R-HSA-9931269	9.828805e-01	0.007	0	0
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	R-HSA-6814122	9.835850e-01	0.007	0	0
eNOS activation	R-HSA-203615	9.835850e-01	0.007	0	0
SARS-CoV-1 modulates host translation machinery	R-HSA-9735869	9.835850e-01	0.007	0	0
Ubiquitin-dependent degradation of Cyclin D	R-HSA-75815	9.835850e-01	0.007	0	0
Gap junction assembly	R-HSA-190861	9.835850e-01	0.007	0	0
Hyaluronan metabolism	R-HSA-2142845	9.835850e-01	0.007	0	0
Calnexin/calreticulin cycle	R-HSA-901042	9.835850e-01	0.007	0	0
Regulation of endogenous retroelements by KRAB-ZFP proteins	R-HSA-9843940	9.842064e-01	0.007	0	0
Regulation of PTEN stability and activity	R-HSA-8948751	9.842949e-01	0.007	0	0
Regulation of PD-L1(CD274) Post-translational modification	R-HSA-9909615	9.843589e-01	0.007	0	0
Acyl chain remodelling of PE	R-HSA-1482839	9.851525e-01	0.006	0	0
Regulation of Apoptosis	R-HSA-169911	9.851525e-01	0.006	0	0
Metabolism of ingested SeMet, Sec, MeSec into H2Se	R-HSA-2408508	9.851525e-01	0.006	0	0
Synthesis of bile acids and bile salts	R-HSA-192105	9.852548e-01	0.006	0	0
Retinoid metabolism and transport	R-HSA-975634	9.853938e-01	0.006	0	0
Adaptive Immune System	R-HSA-1280218	9.857821e-01	0.006	0	0
Glycolysis	R-HSA-70171	9.862259e-01	0.006	0	0
Ion channel transport	R-HSA-983712	9.863156e-01	0.006	0	0
Chaperonin-mediated protein folding	R-HSA-390466	9.864699e-01	0.006	0	0
trans-Golgi Network Vesicle Budding	R-HSA-199992	9.864953e-01	0.006	0	0
Lysosome Vesicle Biogenesis	R-HSA-432720	9.865704e-01	0.006	0	0
AUF1 (hnRNP D0) binds and destabilizes mRNA	R-HSA-450408	9.865704e-01	0.006	0	0
Vif-mediated degradation of APOBEC3G	R-HSA-180585	9.865704e-01	0.006	0	0
GPVI-mediated activation cascade	R-HSA-114604	9.865704e-01	0.006	0	0
Paracetamol ADME	R-HSA-9753281	9.867909e-01	0.006	0	0
Platelet degranulation	R-HSA-114608	9.878081e-01	0.005	0	0
O-glycosylation of TSR domain-containing proteins	R-HSA-5173214	9.878530e-01	0.005	0	0
SIRT1 negatively regulates rRNA expression	R-HSA-427359	9.878530e-01	0.005	0	0
Ubiquinol biosynthesis	R-HSA-2142789	9.878530e-01	0.005	0	0
Beta-oxidation of very long chain fatty acids	R-HSA-390247	9.878530e-01	0.005	0	0
FCERI mediated Ca+2 mobilization	R-HSA-2871809	9.888784e-01	0.005	0	0
Dectin-2 family	R-HSA-5621480	9.888988e-01	0.005	0	0
Metabolism of nitric oxide: NOS3 activation and regulation	R-HSA-202131	9.890132e-01	0.005	0	0
MET promotes cell motility	R-HSA-8875878	9.890132e-01	0.005	0	0
Purine salvage	R-HSA-74217	9.890132e-01	0.005	0	0
Elastic fibre formation	R-HSA-1566948	9.890132e-01	0.005	0	0
Neurotransmitter release cycle	R-HSA-112310	9.891353e-01	0.005	0	0
Cross-presentation of soluble exogenous antigens (endosomes)	R-HSA-1236978	9.900626e-01	0.004	0	0
Diseases associated with N-glycosylation of proteins	R-HSA-3781860	9.900626e-01	0.004	0	0
Respiratory syncytial virus (RSV) genome replication, transcription and translation	R-HSA-9820965	9.900626e-01	0.004	0	0
Interleukin-12 signaling	R-HSA-9020591	9.901544e-01	0.004	0	0
Amino acid transport across the plasma membrane	R-HSA-352230	9.906772e-01	0.004	0	0
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	9.906772e-01	0.004	0	0
Translation of Structural Proteins	R-HSA-9694635	9.909075e-01	0.004	0	0
Generation of second messenger molecules	R-HSA-202433	9.910118e-01	0.004	0	0
rRNA processing in the mitochondrion	R-HSA-8868766	9.910118e-01	0.004	0	0
Tryptophan catabolism	R-HSA-71240	9.910118e-01	0.004	0	0
Mitochondrial tRNA aminoacylation	R-HSA-379726	9.910118e-01	0.004	0	0
Protein folding	R-HSA-391251	9.912948e-01	0.004	0	0
Signaling by Retinoic Acid	R-HSA-5362517	9.914588e-01	0.004	0	0
Glutathione conjugation	R-HSA-156590	9.914588e-01	0.004	0	0
HCMV Infection	R-HSA-9609646	9.916949e-01	0.004	0	0
Aflatoxin activation and detoxification	R-HSA-5423646	9.918704e-01	0.004	0	0
SPOP-mediated proteasomal degradation of PD-L1(CD274)	R-HSA-9929491	9.918704e-01	0.004	0	0
Maturation of spike protein	R-HSA-9694548	9.918704e-01	0.004	0	0
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	9.921585e-01	0.003	0	0
PLC beta mediated events	R-HSA-112043	9.921762e-01	0.003	0	0
Developmental Lineage of Pancreatic Acinar Cells	R-HSA-9925561	9.922505e-01	0.003	0	0
Collagen formation	R-HSA-1474290	9.924992e-01	0.003	0	0
Antigen processing-Cross presentation	R-HSA-1236975	9.926230e-01	0.003	0	0
SLC-mediated transport of neurotransmitters	R-HSA-442660	9.926470e-01	0.003	0	0
Heme biosynthesis	R-HSA-189451	9.926470e-01	0.003	0	0
Translation of Structural Proteins	R-HSA-9683701	9.926470e-01	0.003	0	0
NCAM signaling for neurite out-growth	R-HSA-375165	9.928346e-01	0.003	0	0
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	R-HSA-9856530	9.928479e-01	0.003	0	0
Metabolism of fat-soluble vitamins	R-HSA-6806667	9.934007e-01	0.003	0	0
Amyloid fiber formation	R-HSA-977225	9.934007e-01	0.003	0	0
rRNA modification in the nucleus and cytosol	R-HSA-6790901	9.934386e-01	0.003	0	0
Bile acid and bile salt metabolism	R-HSA-194068	9.935954e-01	0.003	0	0
Response of Mtb to phagocytosis	R-HSA-9637690	9.939849e-01	0.003	0	0
Xenobiotics	R-HSA-211981	9.939926e-01	0.003	0	0
Ion transport by P-type ATPases	R-HSA-936837	9.939926e-01	0.003	0	0
FCERI mediated MAPK activation	R-HSA-2871796	9.944446e-01	0.002	0	0
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	R-HSA-8950505	9.945007e-01	0.002	0	0
EPHB-mediated forward signaling	R-HSA-3928662	9.945597e-01	0.002	0	0
tRNA modification in the nucleus and cytosol	R-HSA-6782315	9.949666e-01	0.002	0	0
SLC transporter disorders	R-HSA-5619102	9.950067e-01	0.002	0	0
ADORA2B mediated anti-inflammatory cytokines production	R-HSA-9660821	9.950795e-01	0.002	0	0
Vasopressin regulates renal water homeostasis via Aquaporins	R-HSA-432040	9.950795e-01	0.002	0	0
Platelet activation, signaling and aggregation	R-HSA-76002	9.951763e-01	0.002	0	0
SLC-mediated transport of amino acids	R-HSA-9958863	9.953937e-01	0.002	0	0
G-protein mediated events	R-HSA-112040	9.953937e-01	0.002	0	0
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	R-HSA-193368	9.953937e-01	0.002	0	0
Formation of the ternary complex, and subsequently, the 43S complex	R-HSA-72695	9.955497e-01	0.002	0	0
ABC-family proteins mediated transport	R-HSA-382556	9.955766e-01	0.002	0	0
O-linked glycosylation of mucins	R-HSA-913709	9.957852e-01	0.002	0	0
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	9.957852e-01	0.002	0	0
Carboxyterminal post-translational modifications of tubulin	R-HSA-8955332	9.959750e-01	0.002	0	0
Major pathway of rRNA processing in the nucleolus and cytosol	R-HSA-6791226	9.960901e-01	0.002	0	0
VEGFA-VEGFR2 Pathway	R-HSA-4420097	9.961216e-01	0.002	0	0
HCMV Late Events	R-HSA-9610379	9.962119e-01	0.002	0	0
Interleukin-12 family signaling	R-HSA-447115	9.962625e-01	0.002	0	0
Pyruvate metabolism	R-HSA-70268	9.962625e-01	0.002	0	0
Neurotransmitter receptors and postsynaptic signal transmission	R-HSA-112314	9.962811e-01	0.002	0	0
G alpha (s) signalling events	R-HSA-418555	9.963238e-01	0.002	0	0
Metal ion SLC transporters	R-HSA-425410	9.963597e-01	0.002	0	0
FCERI mediated NF-kB activation	R-HSA-2871837	9.966427e-01	0.001	0	0
Glucose metabolism	R-HSA-70326	9.966457e-01	0.001	0	0
Opioid Signalling	R-HSA-111885	9.967436e-01	0.001	0	0
Metabolism of cofactors	R-HSA-8978934	9.967738e-01	0.001	0	0
Metabolism of porphyrins	R-HSA-189445	9.967738e-01	0.001	0	0
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	R-HSA-2162123	9.970223e-01	0.001	0	0
Aspirin ADME	R-HSA-9749641	9.973022e-01	0.001	0	0
Complex IV assembly	R-HSA-9864848	9.973069e-01	0.001	0	0
Cytosolic sulfonation of small molecules	R-HSA-156584	9.973069e-01	0.001	0	0
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	R-HSA-975956	9.975235e-01	0.001	0	0
Late SARS-CoV-2 Infection Events	R-HSA-9772573	9.977204e-01	0.001	0	0
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	9.979019e-01	0.001	0	0
Translation initiation complex formation	R-HSA-72649	9.980078e-01	0.001	0	0
Glucuronidation	R-HSA-156588	9.980078e-01	0.001	0	0
Regulation of expression of SLITs and ROBOs	R-HSA-9010553	9.980412e-01	0.001	0	0
G alpha (z) signalling events	R-HSA-418597	9.981983e-01	0.001	0	0
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	R-HSA-9954716	9.982236e-01	0.001	0	0
Signaling by VEGF	R-HSA-194138	9.982711e-01	0.001	0	0
Integrin cell surface interactions	R-HSA-216083	9.982786e-01	0.001	0	0
Cholesterol biosynthesis	R-HSA-191273	9.982786e-01	0.001	0	0
Phospholipid metabolism	R-HSA-1483257	9.983607e-01	0.001	0	0
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	R-HSA-9954709	9.983658e-01	0.001	0	0
Ribosomal scanning and start codon recognition	R-HSA-72702	9.983706e-01	0.001	0	0
Detoxification of Reactive Oxygen Species	R-HSA-3299685	9.983706e-01	0.001	0	0
Influenza Viral RNA Transcription and Replication	R-HSA-168273	9.984044e-01	0.001	0	0
Viral Infection Pathways	R-HSA-9824446	9.984606e-01	0.001	0	0
Potassium Channels	R-HSA-1296071	9.984969e-01	0.001	0	0
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	R-HSA-72662	9.986673e-01	0.001	0	0
Regulation of insulin secretion	R-HSA-422356	9.987289e-01	0.001	0	0
rRNA processing in the nucleus and cytosol	R-HSA-8868773	9.987462e-01	0.001	0	0
Interferon gamma signaling	R-HSA-877300	9.987891e-01	0.001	0	0
Sialic acid metabolism	R-HSA-4085001	9.987947e-01	0.001	0	0
Disorders of transmembrane transporters	R-HSA-5619115	9.988938e-01	0.000	0	0
GABA receptor activation	R-HSA-977443	9.989100e-01	0.000	0	0
Metabolism of polyamines	R-HSA-351202	9.989100e-01	0.000	0	0
Sphingolipid de novo biosynthesis	R-HSA-1660661	9.989100e-01	0.000	0	0
tRNA Aminoacylation	R-HSA-379724	9.989100e-01	0.000	0	0
Nucleotide salvage	R-HSA-8956321	9.990143e-01	0.000	0	0
Aquaporin-mediated transport	R-HSA-445717	9.990143e-01	0.000	0	0
Mitochondrial protein import	R-HSA-1268020	9.991086e-01	0.000	0	0
Influenza Infection	R-HSA-168255	9.991676e-01	0.000	0	0
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	R-HSA-163841	9.992387e-01	0.000	0	0
CD22 mediated BCR regulation	R-HSA-5690714	9.992709e-01	0.000	0	0
Neutrophil degranulation	R-HSA-6798695	9.993481e-01	0.000	0	0
Developmental Cell Lineages of the Exocrine Pancreas	R-HSA-9820448	9.993644e-01	0.000	0	0
Peptide chain elongation	R-HSA-156902	9.993657e-01	0.000	0	0
Ribosome-associated quality control	R-HSA-9948299	9.994446e-01	0.000	0	0
Nicotinate metabolism	R-HSA-196807	9.994608e-01	0.000	0	0
Metabolism of steroid hormones	R-HSA-196071	9.994608e-01	0.000	0	0
Formation of the cornified envelope	R-HSA-6809371	9.994700e-01	0.000	0	0
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	R-HSA-9954714	9.995178e-01	0.000	0	0
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	9.995593e-01	0.000	0	0
Developmental Cell Lineages	R-HSA-9734767	9.995750e-01	0.000	0	0
Eukaryotic Translation Elongation	R-HSA-156842	9.995986e-01	0.000	0	0
Glycosphingolipid catabolism	R-HSA-9840310	9.996013e-01	0.000	0	0
Neuronal System	R-HSA-112316	9.996149e-01	0.000	0	0
Metal ion assimilation from the host	R-HSA-9638482	9.996394e-01	0.000	0	0
Transmission across Chemical Synapses	R-HSA-112315	9.996479e-01	0.000	0	0
Mitochondrial protein degradation	R-HSA-9837999	9.996660e-01	0.000	0	0
Interconversion of nucleotide di- and triphosphates	R-HSA-499943	9.996739e-01	0.000	0	0
Formation of a pool of free 40S subunits	R-HSA-72689	9.997221e-01	0.000	0	0
Eukaryotic Translation Termination	R-HSA-72764	9.997221e-01	0.000	0	0
Asparagine N-linked glycosylation	R-HSA-446203	9.997249e-01	0.000	0	0
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	9.997466e-01	0.000	0	0
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	9.997980e-01	0.000	0	0
Peptide hormone metabolism	R-HSA-2980736	9.998058e-01	0.000	0	0
SLC-mediated transport of organic anions	R-HSA-9955298	9.998217e-01	0.000	0	0
rRNA processing	R-HSA-72312	9.998249e-01	0.000	0	0
Metabolic disorders of biological oxidation enzymes	R-HSA-5579029	9.998388e-01	0.000	0	0
Selenocysteine synthesis	R-HSA-2408557	9.998403e-01	0.000	0	0
Glycerophospholipid biosynthesis	R-HSA-1483206	9.998435e-01	0.000	0	0
Integration of energy metabolism	R-HSA-163685	9.998444e-01	0.000	0	0
Viral mRNA Translation	R-HSA-192823	9.998673e-01	0.000	0	0
Biosynthesis of DHA-derived SPMs	R-HSA-9018677	9.998682e-01	0.000	0	0
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	9.998871e-01	0.000	0	0
Leishmania phagocytosis	R-HSA-9664417	9.998883e-01	0.000	0	0
Parasite infection	R-HSA-9664407	9.998883e-01	0.000	0	0
FCGR3A-mediated phagocytosis	R-HSA-9664422	9.998883e-01	0.000	0	0
Peroxisomal lipid metabolism	R-HSA-390918	9.999025e-01	0.000	0	0
SRP-dependent cotranslational protein targeting to membrane	R-HSA-1799339	9.999166e-01	0.000	0	0
GTP hydrolysis and joining of the 60S ribosomal subunit	R-HSA-72706	9.999240e-01	0.000	0	0
L13a-mediated translational silencing of Ceruloplasmin expression	R-HSA-156827	9.999240e-01	0.000	0	0
Sulfur amino acid metabolism	R-HSA-1614635	9.999280e-01	0.000	0	0
Metabolism of steroids	R-HSA-8957322	9.999401e-01	0.000	0	0
Classical antibody-mediated complement activation	R-HSA-173623	9.999411e-01	0.000	0	0
Class C/3 (Metabotropic glutamate/pheromone receptors)	R-HSA-420499	9.999411e-01	0.000	0	0
Class B/2 (Secretin family receptors)	R-HSA-373080	9.999518e-01	0.000	0	0
Role of phospholipids in phagocytosis	R-HSA-2029485	9.999672e-01	0.000	0	0
FCGR activation	R-HSA-2029481	9.999678e-01	0.000	0	0
Eukaryotic Translation Initiation	R-HSA-72613	9.999701e-01	0.000	0	0
Cap-dependent Translation Initiation	R-HSA-72737	9.999701e-01	0.000	0	0
O-linked glycosylation	R-HSA-5173105	9.999742e-01	0.000	0	0
Scavenging of heme from plasma	R-HSA-2168880	9.999762e-01	0.000	0	0
Mitochondrial translation elongation	R-HSA-5389840	9.999785e-01	0.000	0	0
Leishmania infection	R-HSA-9658195	9.999821e-01	0.000	0	0
Parasitic Infection Pathways	R-HSA-9824443	9.999821e-01	0.000	0	0
Mitochondrial translation initiation	R-HSA-5368286	9.999824e-01	0.000	0	0
Regulation of Complement cascade	R-HSA-977606	9.999872e-01	0.000	0	0
Diseases of glycosylation	R-HSA-3781865	9.999880e-01	0.000	0	0
Innate Immune System	R-HSA-168249	9.999885e-01	0.000	0	0
Mitochondrial ribosome-associated quality control	R-HSA-9937383	9.999894e-01	0.000	0	0
FCGR3A-mediated IL10 synthesis	R-HSA-9664323	9.999894e-01	0.000	0	0
Cytochrome P450 - arranged by substrate type	R-HSA-211897	9.999895e-01	0.000	0	0
Visual phototransduction	R-HSA-2187338	9.999903e-01	0.000	0	0
Creation of C4 and C2 activators	R-HSA-166786	9.999929e-01	0.000	0	0
Immune System	R-HSA-168256	9.999932e-01	0.000	0	0
Synthesis of substrates in N-glycan biosythesis	R-HSA-446219	9.999940e-01	0.000	0	0
Degradation of the extracellular matrix	R-HSA-1474228	9.999945e-01	0.000	0	0
Mitochondrial translation termination	R-HSA-5419276	9.999948e-01	0.000	0	0
Antimicrobial peptides	R-HSA-6803157	9.999957e-01	0.000	0	0
Disease	R-HSA-1643685	9.999959e-01	0.000	1	0
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	9.999961e-01	0.000	0	0
Initial triggering of complement	R-HSA-166663	9.999971e-01	0.000	0	0
Selenoamino acid metabolism	R-HSA-2408522	9.999979e-01	0.000	0	0
Hemostasis	R-HSA-109582	9.999980e-01	0.000	0	0
G alpha (q) signalling events	R-HSA-416476	9.999985e-01	0.000	0	0
Complement cascade	R-HSA-166658	9.999987e-01	0.000	0	0
Infection with Mycobacterium tuberculosis	R-HSA-9635486	9.999987e-01	0.000	0	0
Glycosphingolipid metabolism	R-HSA-1660662	9.999990e-01	0.000	0	0
Anti-inflammatory response favouring Leishmania parasite infection	R-HSA-9662851	9.999992e-01	0.000	0	0
Leishmania parasite growth and survival	R-HSA-9664433	9.999992e-01	0.000	0	0
Respiratory electron transport	R-HSA-611105	9.999995e-01	0.000	0	0
Sphingolipid metabolism	R-HSA-428157	9.999995e-01	0.000	0	0
Keratinization	R-HSA-6805567	9.999997e-01	0.000	0	0
Mitochondrial translation	R-HSA-5368287	9.999998e-01	0.000	0	0
Cell surface interactions at the vascular wall	R-HSA-202733	9.999999e-01	0.000	0	0
Biosynthesis of specialized proresolving mediators (SPMs)	R-HSA-9018678	9.999999e-01	0.000	0	0
Metabolism of proteins	R-HSA-392499	1.000000e+00	0.000	0	0
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	1.000000e+00	0.000	0	0
Arachidonate metabolism	R-HSA-2142753	1.000000e+00	0.000	0	0
Peptide ligand-binding receptors	R-HSA-375276	1.000000e+00	0.000	0	0
Phase II - Conjugation of compounds	R-HSA-156580	1.000000e+00	0.000	0	0
Drug ADME	R-HSA-9748784	1.000000e+00	0.000	0	0
Extracellular matrix organization	R-HSA-1474244	1.000000e+00	0.000	0	0
Bacterial Infection Pathways	R-HSA-9824439	1.000000e+00	0.000	0	0
Phase I - Functionalization of compounds	R-HSA-211945	1.000000e+00	0.000	0	0
SLC-mediated transmembrane transport	R-HSA-425407	1.000000e+00	0.000	0	0
Infectious disease	R-HSA-5663205	1.000000e+00	0.000	0	0
Aerobic respiration and respiratory electron transport	R-HSA-1428517	1.000000e+00	0.000	0	0
GPCR downstream signalling	R-HSA-388396	1.000000e+00	0.000	0	0
Glycosaminoglycan metabolism	R-HSA-1630316	1.000000e+00	0.000	0	0
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	1.000000e+00	0.000	0	0
Infection with Enterobacteria	R-HSA-9640148	1.000000e+00	0.000	0	0
Metabolism of nucleotides	R-HSA-15869	1.000000e+00	0.000	0	0
Metabolism of vitamins and cofactors	R-HSA-196854	1.000000e+00	0.000	0	0
G alpha (i) signalling events	R-HSA-418594	1.000000e+00	0.000	0	0
Signaling by GPCR	R-HSA-372790	1.000000e+00	0.000	0	0
Metabolism of carbohydrates and carbohydrate derivatives	R-HSA-71387	1.000000e+00	0.000	0	0
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	1.000000e+00	0.000	0	0
Translation	R-HSA-72766	1.000000e+00	0.000	0	0
Diseases of metabolism	R-HSA-5668914	1.000000e+00	0.000	0	0
Transport of small molecules	R-HSA-382551	1.000000e+00	0.000	0	0
Biological oxidations	R-HSA-211859	1.000000e+00	0.000	0	0
Expression and translocation of olfactory receptors	R-HSA-9752946	1.000000e+00	-0.000	0	0
Olfactory Signaling Pathway	R-HSA-381753	1.000000e+00	-0.000	0	0
Metabolism of lipids	R-HSA-556833	1.000000e+00	-0.000	0	0
Sensory Perception	R-HSA-9709957	1.000000e+00	-0.000	0	0
Metabolism	R-HSA-1430728	1.000000e+00	-0.000	0	0
GPCR ligand binding	R-HSA-500792	1.000000e+00	-0.000	0	0
Metabolism of amino acids and derivatives	R-HSA-71291	1.000000e+00	-0.000	0	0
Fatty acid metabolism	R-HSA-8978868	1.000000e+00	-0.000	0	0